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1

Nodular regenerative hyperplasia: Evolving concepts on underdiagnosed cause of portal hypertension  

PubMed Central

Nodular regenerative hyperplasia (NRH) is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules. NRH may lead to the development of non-cirrhotic portal hypertension. There are no published systematic population studies on NRH and our current knowledge is limited to case reports and case series. NRH may develop via autoimmune, hematological, infectious, neoplastic, or drug-related causes. The disease is usually asymptomatic, slowly or non-progressive unless complications of portal hypertension develop. Accurate diagnosis is made by histopathology, which demonstrates diffuse micronodular transformation without fibrous septa. Lack of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic liver. While the initial treatment is to address the underlying disease, ultimately the therapy is directed to the management of portal hypertension. The prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal hypertension. In this review we detail the epidemiology, pathogenesis, diagnosis, management, and prognosis of NRH.

Hartleb, Marek; Gutkowski, Krzysztof; Milkiewicz, Piotr

2011-01-01

2

Gastric variceal bleeding uncovering a rare association of CREST syndrome, primary biliary cirrhosis, nodular regenerative hyperplasia and pulmonary hypertension.  

PubMed

A 73-year-old woman was admitted after the first upper gastric tract haemorrhage due to gastric variceal bleeding. A CREST syndrome associated with Hashimoto's thyroiditis, Gougerot-Sjögren syndrome, cryoglobulinaemia and complicated with severe pulmonary hypertension was diagnosed. Liver histology found precirrhotic lesions of primary biliary cirrhosis (PBC) and nodular regenerative hyperplasia (NRH). Collagen diseases are often associated with liver test abnormalities and liver disease usually associated with CREST syndrome is PBC. NRH has been found in association with collagen diseases but also with haematological diseases or drugs or with autoimmune diseases, such as PBC. This case shows the association of PBC and NRH with porto pulmonary hypertension in CREST syndrome. PMID:20485183

Riviere, Etienne; Vergniol, Julien; Reffet, Armel; Lippa, Nicolas; Le Bail, Brigitte; de Ledinghen, Victor

2010-09-01

3

Nodular regenerative hyperplasia of the liver: coral atoll-like lesions on ultrasound are characteristic in predisposed patients.  

PubMed

Nodular regenerative hyperplasia (NRH) is an uncommon liver disease characterised histologically by numerous small hyperplastic nodules that are not separated by fibrotic tissue. It is thought to be the result of obliterative vasculopathy, and it has been associated with chronic use of medications, toxic substances and a wide variety of systemic diseases. Imaging diagnosis of early-stage NRH remains problematic. The nodules are rarely discerned and their appearance and behaviour before and after contrast medium administration are heterogeneous and not specific. A review of the literature shows that ultrasound has succeeded on occasion in revealing small focal liver lesions in patients with NRH. To our knowledge, there has been no published data on the performance in this setting of last-generation ultrasound scanners and techniques such as contrast-enhanced ultrasound (CEUS). The question is an important one because abdominal ultrasound is widely used as a first-line imaging technique for the evaluation of liver disease, and this makes it particularly suitable as a potential tool for the early diagnosis of NRH. Owing to the prolonged subclinical period and the limited help provided by imaging, the diagnosis in vivo of NRH is currently frequently missed, and it is still made exclusively on the basis of liver biopsy. In conclusion, this report describes 4 cases of biopsy-proven NRH that have been diagnosed over the past 2 years by our group. All were characterised by known comorbidities that confer a predisposition to NRH and by a peculiar parenchymal ultrasound pattern that we refer to as the "atoll sign". PMID:21697407

Caturelli, E; Ghittoni, G; Ranalli, T V; Gomes, V V

2011-07-01

4

[Turner syndrome and nodular regenerative hyperplasia of the liver].  

PubMed

Turner's syndrome is an ovarian dysgenesis (karyotype 45 X0) characterized by sexual infantilism and multiple malformations. Liver enzyme anomalies are often observed, but the underlying pathogenic mechanism remains unknown. Nodular regenerative hyperplasia of the liver is associated with another disease in about 80% of cases. However, these two diseases have only been reported together in one woman. We describe here a second case of this association "Turner's syndrome and nodular regenerative hyperplasia". We think that women with Turner's syndrome should benefit from screening for nodular regenerative hyperplasia by searching for elevated liver enzymes. This easily applicable screening protocol would provide early diagnostic of nodular regenerative hyperplasia and allow early and effective treatment of portal hypertension. Moreover, this approach would improve our knowledge of this association. PMID:9791565

Thevenot, T; Dhote, R; Tulliez, M; Baverel, F; Permal, S; Rabineau, D; Christoforov, B

1998-09-01

5

Hepatoportal sclerosis (obliterative portal venopathy) and nodular regenerative hyperplasia in a patient with myasthenia gravis: A case report and review of the published work.  

PubMed

Nodular regenerative hyperplasia (NRH) and hepatoportal sclerosis, also known as obliterative portal venopathy (OPV), are two causes of non-cirrhotic portal hypertension (NCPH). NCPH is an increasingly recognized entity that can be seen in association with collagen vascular diseases and with the use of medications such as azathioprine and didanosine, but oftentimes the etiology remains unidentified. We herein report a case of NCPH occurring due to OPV and NRH in a 64-year-old woman with myasthenia gravis (MG), status post-thymectomy. Portal hypertension was diagnosed incidentally on computed tomography in the absence of predisposing factors. Extensive work-up to determine the etiology of any underlying liver disease was unrevealing. NRH and OPV were identified on liver biopsy. Subsequently, the patient had variceal bleeding that necessitated transjugular intrahepatic portosystemic shunt placement. A few similar cases of NCPH occurring in the setting of MG have been previously reported, suggesting that the immunological mechanisms involved in the pathogenesis of myasthenia may also have contributed to the development of NCPH. PMID:23675894

Agrawal, Manasi; Rahmani, Rabin; Nakkala, Kiran; Fiel, Maria Isabel; Schiano, Thomas

2013-05-15

6

NRH Neuroscience Research Center.  

National Technical Information Service (NTIS)

The goal of the funded work was to establish the NRH Neuroscience Research Center (NRC) whose mission is to promote and accomplish rehabilitation- related basic and applied neuroscience research. Funding supported the development of research studies in th...

A. Dromerick

2008-01-01

7

NRH Neuroscience Research Center.  

National Technical Information Service (NTIS)

The NRH Neuroscience Research Center (NRC) mission is to promote and accomplish rehabilitation- related basic and applied neuroscience research. As part of this mission, the NRC: (1) develops new clinical interventions for patients with neurologically bas...

E. B. Healton

2004-01-01

8

NRH Neuroscience Research Center.  

National Technical Information Service (NTIS)

The NRH Neuroscience Research Center (NRC) mission is to promote and accomplish rehabilitation-related basic and applied neuroscience research. As part of this mission, the NRC: (1) Develops new clinical interventions for patients with neurologically base...

E. B. Healton

2005-01-01

9

NRH Neuroscience Research Center.  

National Technical Information Service (NTIS)

The NRH Neuroscience Research Center (NRC) mission is to promote and accomplish rehabilitation-related basic and applied neuroscience research. AS part of this mission, the NRC: (1) develops new clinical interventions for patients with neurologically base...

A. W. Dromerick E. Healton

2006-01-01

10

Nodular regenerative hyperplasia of the liver associated with systemic lupus erythematosus: three cases.  

PubMed

Nodular regenerative hyperplasia of the liver, characterised by regenerative nodules distributed throughout the liver in the absence of fibrosis, is a rare but important complication of systemic lupus erythematosus. The main consequence of nodular regenerative hyperplasia of the liver is non-cirrhotic portal hypertension. This condition is probably underdiagnosed, as many of these patients may remain asymptomatic. Furthermore, nodular regenerative hyperplasia of the liver may be misdiagnosed as cirrhosis. We describe three female patients with nodular regenerative hyperplasia of the liver associated with systemic lupus erythematosus. All three patients have clinical manifestations of portal hypertension, and all were initially misdiagnosed as having cryptogenic cirrhosis. PMID:19342741

Leung, Vincent K S; Loke, Tony K L; Luk, Ivy S C; Ng, W L; Chau, T N; Law, S T; Chan, James C S

2009-04-01

11

Nodular regenerative hyperplasia of the liver, CREST syndrome and primary biliary cirrhosis: an overlap syndrome?  

Microsoft Academic Search

Nodular regenerative hyperplasia of the liver (NRHL) has been found in association with collagen vascular diseases, after drug therapy, with autoimmune disease, and with a variety of haematological disorders. The association of NRHL with the syndrome of Calcinosis cutis, Raynaud's phenomenon, oesophageal dysfunction, sclerodactyly and telangiectasia (CREST syndrome) has only been reported on two previous occasions. The liver disease usually

R F McMahon; C Babbs; T W Warnes

1989-01-01

12

Diffuse Muscular Pain, Skin Tightening, and Nodular Regenerative Hyperplasia Revealing Paraneoplastic Amyopathic Dermatomyositis due to Testicular Cancer  

PubMed Central

Paraneoplastic dermatomyositis (DM) associated with testicular cancer is extremely rare. We report the case of a patient with skin tightening, polymyalgia, hypereosinophilia, and nodular regenerative hyperplasia revealing seminoma and associated paraneoplastic DM.

Norrenberg, Sarah; Gangji, Valerie; Del Marmol, Veronique; Soyfoo, Muhammad S.

2012-01-01

13

Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver.  

PubMed Central

Studies with tumor necrosis factor p55 receptor- and interleukin-6 (IL-6)-deficient mice have shown that IL-6 is required for hepatocyte proliferation and reconstitution of the liver mass after partial hepatectomy. The biological activities of IL-6 are potentiated when this cytokine binds soluble forms of its specific receptor subunit (sIL-6R) and the resulting complex interacts with the transmembrane signaling chain gp130. We show here that double transgenic mice expressing high levels of both human IL-6 and sIL-6R under the control of liver-specific promoters spontaneously develop nodules of hepatocellular hyperplasia around periportal spaces and present signs of sustained hepatocyte proliferation. The resulting picture is identical to that of human nodular regenerative hyperplasia, a condition frequently associated with immunological and myeloproliferative disorders. In high expressors, hyperplastic lesions progress with time into discrete liver adenomas. These data strongly suggest that the IL-6/sIL-6R complex is both a primary stimulus to hepatocyte proliferation and a pathogenic factor of hepatocellular transformation.

Maione, D; Di Carlo, E; Li, W; Musiani, P; Modesti, A; Peters, M; Rose-John, S; Della Rocca, C; Tripodi, M; Lazzaro, D; Taub, R; Savino, R; Ciliberto, G

1998-01-01

14

Regenerative burner  

Microsoft Academic Search

This patent describes a method of combusting fuel in a furnace having a pair of regenerative burners, each burner having a combustion chamber. It comprises: supplying fuel and oxygen alternatively to each burner to create alternating firing burners wherein the oxygen is supplied from two sources providing first and second oxidizing gases having different oxygen concentrations and simultaneously alternating the

Gitman

1990-01-01

15

Fully relayed regenerative amplifier  

DOEpatents

A regenerative laser apparatus and method using the optical relay concept to maintain high fill factors, to suppress diffraction effects, and to minimize phase distortions in a regenerative amplifier.

Glass, Alexander J. (Berkeley, CA)

1981-01-01

16

Regenerative medicine primer.  

PubMed

The pandemic of chronic diseases, compounded by the scarcity of usable donor organs, mandates radical innovation to address the growing unmet needs of individuals and populations. Beyond life-extending measures that are often the last available option, regenerative strategies offer transformative solutions in treating degenerative conditions. By leveraging newfound knowledge of the intimate processes fundamental to organogenesis and healing, the emerging regenerative armamentarium aims to boost the aptitude of human tissues for self-renewal. Regenerative technologies strive to promote, augment, and reestablish native repair processes, restituting organ structure and function. Multimodal regenerative approaches incorporate transplant of healthy tissues into damaged environments, prompt the body to enact a regenerative response in damaged tissues, and use tissue engineering to manufacture new tissue. Stem cells and their products have a unique aptitude to form specialized tissues and promote repair signaling, providing active ingredients of regenerative regimens. Concomitantly, advances in materials science and biotechnology have unlocked additional prospects for growing tissue grafts and engineering organs. Translation of regenerative principles into practice is feasible and safe in the clinical setting. Regenerative medicine and surgery are, thus, poised to transit from proof-of-principle studies toward clinical validation and, ultimately, standardization, paving the way for next-generation individualized management algorithms. PMID:23809322

Terzic, Andre; Nelson, Timothy J

2013-07-01

17

Benign prostate hyperplasia (BPH) - resources  

MedlinePLUS

Resources - benign prostatic hyperplasia (BPH); Prostate enlargement resources; BPH resources ... following organizations provide information on benign prostatic hyperplasia ( prostate enlargement ): National Kidney and Urologic Diseases Information Clearinghouse - ...

18

Reversible papillary hyperplasia of the rat urinary bladder.  

PubMed Central

A rapid reproducible method for the production of ulcers and reversible regenerative hyperplasia of the urinary bladder of rats is described. This method does not involve administration of a toxic chemical or retention of a foreign body. Ulceration was produced by means of applying a steel rod, 5 mm in diameter, frozen at -78 C, to the serosal surface of the bladder for 2 seconds, twice, with a 5-second interval between each application. Sequential histologic observations showed that ulcers were accompanied by necrosis of the entire thickness of the bladder at the site of freezing with extensive acute inflammation. Regenerative hyperplasia was evident at the edge of the ulcer by the second day, with greatest severity at 5 days when papillary and nodular hyperplasia were present. At 15 days the bladders were normal or had only minimal hyperplasia. The labeling index by autoradiography was highest in the mildly hyperplastic area near the ulcer at 2 days and remained relatively high through 5 days. The hyperplastic epithelium surrounding the ulcer observed by scanning electron microscopy had numerous degenerative cells on the surface, and small epithelial cells with numerous short, uniform microvilli on their luminal surface were also observed. The numerous short, uniform microvilli on their luminal surface were also observed. The microvilli had a symmetric luminal membrane, as observed on trasmission electron microscopy. More peripherally the cells had microridges only or microvilli and microridges on their luminal surface. Neither pleomorphic microvili nor a structured glycocalyx fuzz on microvilli was observed during the process of regenerative hyperplasia, distinguishing it from neoplastic bladder proliferations. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11

Shirai, T.; Cohen, S. M.; Fukushima, S.; Hananouchi, M.; Ito, N.

1978-01-01

19

Regenerative medicine in urology.  

PubMed

The term 'regenerative medicine' encompasses strategies for restoring or renewing tissue or organ function by: (i) in vivo tissue repair by in-growth of host cells into an acellular natural or synthetic biomaterial, (ii) implantation of tissue 'engineered'in vitro by seeding cultured cells into a biomaterial scaffold, and (iii) therapeutic cloning and stem cell-based tissue regeneration. In this article, we review recent developments underpinning the emerging science of regenerative medicine and critically assess where successful implementation of novel regenerative medicine approaches into urology practice might genuinely transform the quality of life of affected individuals. We advocate the need for an evidence-based approach supported by strong science and clinical objectivity. PMID:21895928

Wezel, Felix; Southgate, Jennifer; Thomas, David F M

2011-09-06

20

Integrated Regenerative Fuel Cell Investigation.  

National Technical Information Service (NTIS)

A regenerative stack consisting of four hydrogen-oxygen fuel cells and two electrolysis cells was designed, fabricated, and successfully tested for 48 cycles. The regenerative stack was operated over the following range of parameters: fuel cell current de...

J. V. Clausi

1970-01-01

21

MMIC regenerative divider  

Microsoft Academic Search

This paper reports on performance of a UHF MMIC regenerative divider designed and fabricated at the Northrop Grumman Advanced Technology Labs. It uses Northrop Grumman Corporations standard GaAs HBT low phase noise process in order to achieve superior phase noise performance. Use of the MMIC divider results in a 50:1 area reduction in circuit size, compared to dividers employing discrete,

Trang Pham; Howard N. Fudem; Pat Green; Michael M. Driscoll; Pat Dever; Mike Hauser

2008-01-01

22

Regenerative Medicine 2006.  

National Technical Information Service (NTIS)

The Greek Titan, Prometheus, is a fitting symbol for regenerative medicine. As punishment for giving fire to Humankind, Zeus ordered Prometheus chained to a rock and sent an eagle to eat his liver each day. However, Prometheus liver was able to regenerate...

2010-01-01

23

Hydrogels in Regenerative Medicine  

Microsoft Academic Search

Hydrogels,due totheiruniquebiocompatibility,flexiblemethodsofsynthesis, range of constituents, and desirable physical characteristics, have been the material of choice for many applications in regenerative medicine. They can serve as scaffolds that provide structural integrity to tissue constructs, control drug and protein delivery to tissues and cultures, and serve as adhesives or barriers between tissue and material surfaces. In this work, the properties of hydrogels

Brandon V. Slaughter; Shahana S. Khurshid; Omar Z. Fisher; Ali Khademhosseini; Nicholas A. Peppas

2009-01-01

24

PEM regenerative fuel cells  

Microsoft Academic Search

This paper will update the progress in developing electrocatalyst systems and electrode structures primarily for the positive electrode of single-unit solid polymer proton exchange membrane (PEM) regenerative fuel cells. The work was done with DuPont Nafion 117 in complete fuel cells (40 sq cm electrodes). The cells were operated alternately in fuel cell mode and electrolysis mode at 80 C.

Larry L. Swette; Anthony B. Laconti; Stephen A. McCatty

1993-01-01

25

NAD(P)H: Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 Polymorphisms in Papillary Thyroid Microcarcinoma: Correlation with Phenotype  

PubMed Central

Purpose NAD(P)H:Quinone Oxidoreductase 1 (NQO1) C609T missense variant (NQO1*2) and 29 basepair (bp)-insertion/deletion (I29/D) polymorphism of the NRH:Quinone Oxidoreductase 2 (NQO2) gene promoter have been proposed as predictive and prognostic factors for cancer development and progression. The purpose of this study is to investigate the relationship between NQO1/NQO2 genotype and clinico-pathological features of papillary thyroid microcarcinoma (PTMC). Materials and Methods Genomic DNA was isolated from 243 patients; and clinical data were retrospectively analyzed. NQO1*2 and tri-allelic polymorphism of NQO2 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Results PTMC with NQO1*2 frequently exhibited extra-thyroidal extension as compared to PTMC with wild-type NQO1 (p=0.039). There was a significant relationship between I29/I29 homozygosity of NQO2 and lymph node metastasis (p=0.042). Multivariate analysis showed that the I29/I29 genotype was associated with an increased risk of lymph node metastasis (OR, 2.24; 95% CI, 1.10-4.56; p=0.026). Conclusion NQO1*2 and I29 allele of the NQO2 are associated with aggressive clinical phenotypes of PTMC, and the I29 allele represents a putative prognostic marker for PTMC.

Lee, Junguee; Kim, Koon Soon; Lee, Min Ho; Kim, Yeon Soo; Lee, Min Hee; Lee, Seong Eun; Kim, Yong Kyung; Ryu, Min Jeong; Kim, Soung Jung; Choi, Min Jeong

2013-01-01

26

Regenerative photonic therapy: Review  

NASA Astrophysics Data System (ADS)

After four decades of research of photobiomodulation phenomena in mammals in vitro and in vivo, a solid foundation is created for the use of photobiomodulation in regenerative medicine. Significant accomplishments are achieved in animal models that demonstrate opportunities for photo-regeneration of injured or pathological tissues: skin, muscles and nerves. However, the use of photobiomodulation in clinical studies leads to controversial results while negative or marginal clinical efficacy is reported along with positive findings. A thor ough analysis of requirements to the optical parameters (dosimetry) for high efficacy in photobimodulation led us to the conclusion that there are several misconceptions in the clinical applications of low level laser therapy (LLLT). We present a novel appr oach of regenerative photonic therapy (RPT) for tissue healing and regeneration that overcomes major drawbacks of LLLT. Encouraging clinical results on RPT efficacy are presented. Requirements for RPT approach and vision for its future development for tissue regeneration is discussed.

Salansky, Natasha; Salansky, Norman

2012-09-01

27

Regenerative fuel cells  

Microsoft Academic Search

A development status evaluation is presented for moderate-temperature, single-unit, regenerative fuel cells using either alkaline or solid polymer proton-exchange membrane (PEM) electrolytes. Attention is given to the results thus far obtained for Pt, Ir, Rh, and Na(x)Pt3O4 catalysts. Alkaline electrolyte tests have been performed on a half-cell basis with a floating-electrode cell; PEM testing has been with complete fuel cells,

Larry L. Swette; Nancy D. Kackley; Anthony B. Laconti

1992-01-01

28

Regenerative fuel cells  

NASA Astrophysics Data System (ADS)

A development status evaluation is presented for moderate-temperature, single-unit, regenerative fuel cells using either alkaline or solid polymer proton-exchange membrane (PEM) electrolytes. Attention is given to the results thus far obtained for Pt, Ir, Rh, and Na(x)Pt3O4 catalysts. Alkaline electrolyte tests have been performed on a half-cell basis with a floating-electrode cell; PEM testing has been with complete fuel cells, using Nafion 117.

Swette, Larry L.; Kackley, Nancy D.; Laconti, Anthony B.

29

Cytomics in regenerative medicine  

NASA Astrophysics Data System (ADS)

Cytomics is the high-content analysis of cell-systems [6, 78]. The area of Cytomics and Systems Biology received great attention during the last years as it harbours the promise to substantially impact on various fields of biomedicine, drug discovery, predictive medicine [6] and may have major potential for regenerative medicine. In regenerative medicine Cytomics includes process control of cell preparation and culturing using non-invasive detection techniques, quality control and standardization for GMP and GLP conformity and even prediction of cell fate based on sophisticated data analysis. Cytomics requires quantitative and stoichiometric single cell analysis. In some areas the leading cytometric techniques represent the cutting edge today. Many different applications/variations of multicolour staining were developed for flow- or slide-based cytometry (SBC) analysis of suspensions and sections to whole animal analysis [78]. SBC has become an important analytical technology in drug discovery, diagnosis and research and is an emerging technology for systems analysis [78]. It enables high-content high-throughput measurement of cell suspensions, cell cultures and tissues. In the last years various commercial SBC instruments were launched principally enabling to perform similar tasks. Standardisation as well as comparability of different instruments is a major challenge. Hyperspectral optical imaging may be implemented in SBC analysis for label free cell detection based on cellular autofluorescence [3]. All of these developments push the systemic approach of the analysis of biological specimens to enhance the outcome of regenerative medicine.

Tárnok, Attila; Pierzchalski, Arkadiusz

2008-03-01

30

Regenerative medicine strategies.  

PubMed

Applications of regenerative medicine technology may offer novel therapies for patients with injuries, end-stage organ failure, or other clinical problems. Currently, patients suffering from diseased and injured organs can be treated with transplanted organs. However, there is a severe shortage of donor organs that is worsening yearly as the population ages and new cases of organ failure increase. Scientists in the field of regenerative medicine and tissue engineering are now applying the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. The stem cell field is also advancing rapidly, opening new avenues for this type of therapy. For example, therapeutic cloning and cellular reprogramming may one day provide a potentially limitless source of cells for tissue engineering applications. While stem cells are still in the research phase, some therapies arising from tissue engineering endeavors have already entered the clinical setting successfully, indicating the promise regenerative medicine holds for the future. PMID:22244387

Atala, Anthony

2012-01-01

31

Regenerative Power Control for Electric Bicycle  

Microsoft Academic Search

This paper presents the design regenerative power control for electric bicycle. PM brushless dc motor use on electric bicycle. In electrical bicycle system occurs due to the regenerative power regulating to prevent a DC-link over-voltage condition. Regenerative power control circuit is absorbing regenerative power in the battery. Details of the motor and the electronic converter are given. The regenerative power

N. Somchaiwong; W. Ponglangka

2006-01-01

32

Regenerative air heater  

DOEpatents

A gas-cooled steel skirt is used to support a refractory cored brick matrix and dome structure in a high temperature regenerative air heater useful in magnetohydrodynamic power generation. The steel skirt thermally expands to accommodate the thermal expansion of the dome structure despite substantial temperature differential thereby reducing relative movement between the dome bricks. Gas cooling of the steel skirt allows the structure to operate above its normal temperature during clean-out cycles and also allows for the control of the thermal expansion of the steel skirt.

Hasselquist, Paul B. (Maple Grove, MN); Baldner, Richard (Minnetonka, MN)

1982-01-01

33

Regenerative air heater  

DOEpatents

A gas-cooled steel skirt is used to support a refractory cored brick matrix and dome structure in a high temperature regenerative air heater useful in magnetohydrodynamic power generation. The steel skirt thermally expands to accommodate the thermal expansion of the dome structure despite substantial temperature differential thereby reducing relative movement between the dome bricks. Gas cooling of the steel skirt allows the structure to operate above its normal temperature during clean-out cycles and also allows for the control of the thermal expansion of the steel skirt.

Hasselquist, P.B.; Baldner, R.

1980-11-26

34

Esophagus and regenerative medicine  

PubMed Central

In addition to squamous cell carcinoma, the incidence of Barrett’s esophagus with high-grade dysplasia and esophageal adenocarcinoma is rapidly increasing worldwide. Unfortunately, the current standard of care for esophageal pathology involves resection of the affected tissue, sometimes involving radical esophagectomy. Without exception, these procedures are associated with a high morbidity, compromised quality of life, and unacceptable mortality rates. Regenerative medicine approaches to functional tissue replacement include the use of biological and synthetic scaffolds to promote tissue remodeling and growth. In the case of esophageal repair, extracellular matrix (ECM) scaffolds have proven to be effective for the reconstruction of small patch defects, anastomosis reinforcement, and the prevention of stricture formation after endomucosal resection (EMR). More so, esophageal cancer patients treated with ECM scaffolds have shown complete restoration of a normal, functional, and disease-free epithelium after EMR. These studies provide evidence that a regenerative medicine approach may enable aggressive resection of neoplastic tissue without the need for radical esophagectomy and its associated complications.

Londono, Ricardo; Jobe, Blair A; Hoppo, Toshitaka; Badylak, Stephen F

2012-01-01

35

Polymeric Scaffolds for Regenerative Medicine  

Microsoft Academic Search

Regenerative medicine, one of the most exciting and dynamic life science fields, is an emerging biomedical technology for assisting and accelerating the regeneration and repair of lost or damaged organs or body parts. Modern regenerative medicine is increasingly using three-dimensional structured scaffolds because they represent a wide range of morphological and geometric in vivo possibilities that can be tailored for

Moon Suk Kim; Jae Ho Kim; Byoung Hyun Min; Heung Jae Chun; Dong Keun Han; Hai Bang Lee

2011-01-01

36

Regenerative periodontal therapy.  

PubMed

Traditional treatment for loss of bone and attachment due to periodontal disease has focused around repairing the damage induced. However, over the past few decades, clinicians have begun to utilize regenerative techniques to rebuild bone, cementum and the periodontal ligament. Conventional procedures most often involve the use of barrier membranes with bone grafts that foster selective cell repopulation and regrowth of osseous structures. Since the predictability of these techniques may be limited to certain case types, pharmacologically based efforts are underway to investigate the possibility of harnessing osseous regrowth potential. Clinical research has found that proteins are potent biological mediators that promote many of the events in wound healing, and have been shown to promote bone formation in human clinical studies. PMID:22142962

Kao, Daniel W K; Fiorellini, Joseph P

2011-11-11

37

Regenerative braking device  

DOEpatents

Disclosed are several embodiments of a regenerative braking device for an automotive vehicle. The device includes a plurality of rubber rollers (24, 26) mounted for rotation between an input shaft (14) connectable to the vehicle drivetrain and an output shaft (16) which is drivingly connected to the input shaft by a variable ratio transmission (20). When the transmission ratio is such that the input shaft rotates faster than the output shaft, the rubber rollers are torsionally stressed to accumulate energy, thereby slowing the vehicle. When the transmission ratio is such that the output shaft rotates faster than the input shaft, the rubber rollers are torsionally relaxed to deliver accumulated energy, thereby accelerating or driving the vehicle.

Hoppie, Lyle O. (Birmingham, MI)

1982-01-12

38

Carbon Nanotubes in Regenerative Medicine  

Microsoft Academic Search

\\u000a This chapter focuses on the latest developments in applications of carbonnanotubes (CNTs) for regenerative medicine. Regenerative\\u000a Medicine focuses on technologies to create functional tissues to repair or replace tissues or organs lost due to trauma or\\u000a disease. Carbon nonotubes (CNTs) have been under investigation in the past decade for an array of applications due to their\\u000a unique and versatile properties.

Bhavna S. Paratala; Balaji Sitharaman

39

Intimal Hyperplasia in Murine Models  

PubMed Central

The most commonly used procedures to induce arterial injury in mice are carotid artery ligation with cessation of blood flow and mechanically-induced denudation of endothelium in the carotid or the femoral arteries. Both procedures result in neointimal hyperplasia after two to three weeks. A survey of various inbred strain of mice shows that strain-specific differences in susceptibility to injury-induced neointimal hyperplasia are different than those for susceptibility to diet-induced atherosclerosis, with strains identified as susceptible to both neointimal hyperplasia and atherosclerosis, resistant to both, susceptible to atherosclerosis but resistant to neointimal hyperplasia, or resistant to atherosclerosis but susceptible to neointimal hyperplasia. Inflammatory cells such as T and B lymphocytes, which are contributory to atherosclerosis, are protective against injury-induced neointimal hyperplasia. In contrast, the infiltration of monocytes into the site of injury and their differentiation to macrophages favor neointimal hyperplasia similar to their pathogenic role in atherosclerosis. The regulatory role of lymphocytes and macrophages in neointimal hyperplasia is related to the production of cytokines such as interferon-? and tumor necrosis factor-?, respectively. Interestingly, inducible nitric oxide synthase (iNOS) activity appears to inhibit neointimal hyperplasia in the endothelial denudation model but contributes to neointimal hyperplasia when arterial injury is induced by periadventitial cuff placement. The difference appears to be due to the time required for endothelial recovery and the participation of inflammatory cells. Thus, although arterial injury-induced neointimal hyperplasia results in similar vascular occlusion as progressive atherosclerosis, the pathology and mechanism of the two disease processes are quite different.

Hui, David Y.

2010-01-01

40

[Congenital lipoid adrenal hyperplasia].  

PubMed

Congenital lipoid adrenal hyperplasia(CLAH) is known as the severest form of congenital adrenal hyperplasia, which is characterized by the lack of biosynthesis of all steroid hormones and its metabolites due to the failure in converting cholesterol to pregnenolone, the first and rate-limiting step of steroid synthesis. The genetic etiology has been identified; trafficking defect of cholesterol to mitochondria due to defect of StAR gene, and conversion defect of cholesterol to pregnenolone at mitochondrial membrane due to the defect of CYP11A, cholesterol side chain cleavage enzyme. The advancement of genetical analysis has revealed that the clinical feature is not only defined as severe salt-loosing and complete failure of musculinization, but also as relatively mild or late-onset form. Spontaneous puberty may exhibit to 46,XX patients while 46,XY subjects will never show pubertal signs. It suggested that 1) it may take more time to deposit lipid particles to cause irreversible damage to ovary than to testis, 2) there exists the other ways in cholesterol trafficking which rescue the StAR deficiency. PMID:14968544

Horikawa, Reiko

2004-02-01

41

The Biology of Regenerative Medicine  

NSDL National Science Digital Library

The goal of regenerative medicine is to restore the structure and function of human body parts compromised by injury or disease. Regenerative medicine is a relatively new field that uses multiple approaches and has its roots largely in tissue engineering, tissue transplantation, and stem cell biology. It is becoming increasingly clear that advances in the areas of regeneration biology and developmental biology have the potential to transform regenerative medicine, and David Stocum has produced a textbook that attempts to pull everything together for the next generation of regeneration scientists. Regeneration Biology and Medicine is a terrific reference for anyone toying with the idea of moving into this field. The text offers an enormous breath of coverage of different systems currently under investigation, and Stocum provides a central theme that pits regenerative ability against fibrosis as a way to conceptually untangle the limited regenerative capacity of humans. In writing this textbook, Stocum has erected an umbrella large enough for scientists of diverse backgrounds to initiate conceptual cross-talk between those actively involved in the biology of regeneration and those targeting its clinical application.

Ken Muneoka (Tulane University;Department of Cell and Molecular Biology REV)

2007-06-05

42

Congenital adrenal hyperplasia  

PubMed Central

Congenital adrenal hyperplasia consists of a heterogenous group of inherited disorders due to enzymatic defects in the biosynthetic pathway of cortisol and/or aldosterone. This results in glucocorticoid deficiency, mineralocorticoid deficiency, and androgen excess. 95% of CAH cases are due to 21-hydroxylase deficiency. Clinical forms range from the severe, classical CAH associated with complete loss of enzyme function, to milder, non-classical forms (NCAH). Androgen excess affects the pilosebaceous unit, causing cutaneous manifestations such as acne, androgenetic alopecia and hirsutism. Clinical differential diagnosis between NCAH and polycystic ovary syndrome may be difficult. In this review, the evaluation of patients with suspected CAH, the clinical presentation of CAH forms, with emphasis on the cutaneous manifestations of the disease, and available treatment options, will be discussed.

Dessinioti, Cleo; Katsambas, Andreas

2009-01-01

43

Congenital hemifacial hyperplasia  

PubMed Central

Congenital hemifacial hyperplasia (CHH) is a rare congenital malformation characterized by marked unilateral overdevelopment of hard and soft tissues of the face. Asymmetry in CHH is usually evident at birth and accentuated with age, especially at puberty. The affected side grows at a rate proportional to the nonaffected side so that the disproportion is maintained thr oughout the life. Multisystem involvement has resulted in etiological heterogeneity including heredity, chromosomal abnormalities, atypical forms of twinning, altered intrauterine environment, and endocrine dysfunctions; however, no single theory explains the etiology adequately. Deformities of all tissues of face, including teeth and their related tissues in the jaw, are key findings for correct diagnosis of CHH. Here an attempt has been made to present a case of CHH with its archetypal features and to supplement existing clinical knowledge.

Deshingkar, S. A.; Barpande, S. R.; Bhavthankar, J. D.

2011-01-01

44

Laser system using regenerative amplifier  

DOEpatents

High energy laser system using a regenerative amplifier, which relaxes all constraints on laser components other than the intrinsic damage level of matter, so as to enable use of available laser system components. This can be accomplished by use of segmented components, spatial filters, at least one amplifier using solid state or gaseous media, and separated reflector members providing a long round trip time through the regenerative cavity, thereby allowing slower switching and adequate time to clear the spatial filters, etc. The laser system simplifies component requirements and reduces component cost while providing high energy output.

Emmett, John L. (Pleasanton, CA)

1980-01-01

45

Laser system using regenerative amplifier  

DOEpatents

High energy laser system is disclosed using a regenerative amplifier, which relaxes all constraints on laser components other than the intrinsic damage level of matter, so as to enable use of available laser system components. This can be accomplished by use of segmented components, spatial filters, at least one amplifier using solid state or gaseous media, and separated reflector members providing a long round trip time through the regenerative cavity, thereby allowing slower switching and adequate time to clear the spatial filters, etc. The laser system simplifies component requirements and reduces component cost while providing high energy output. 10 figs.

Emmett, J.L.

1980-03-04

46

Potential of endogenous regenerative technology for in situ regenerative medicine  

Microsoft Academic Search

Endogenous regenerative technology (Endoret) involves the use of patient's own biologically active proteins, growth factors and biomaterial scaffolds for therapeutic purposes. This technology provides a new approach for the stimulation and acceleration of tissue healing and bone regeneration. The versatility and biocompatibility of using patient-derived fibrin scaffold as an autologous, biocompatible and biodegradable drug delivery system open the door to

Eduardo Anitua; Mikel Sánchez; Gorka Orive

2010-01-01

47

Regenerative medicine for craniomaxillofacial surgery.  

PubMed

Regenerative medicine has recently seen much activity in basic and translational research. These advances are now making their way into surgical practice. A convergence of technologies has afforded opportunities previously not available with conventional surgical reconstructive techniques. Patients requiring complex reconstructive surgery in the craniomaxillofacial region typically benefit from local or regional flaps, nonvascularized grafts, microvascular tissue transfer, or substitute alloplastic materials to restore function and form. In these clinical situations, grafting procedures or alloplastic substitute materials provide best-case replacements for resected, injured, or congenitally missing tissues. However, ideal reconstructive goals, such as a complete return to original form and function, are frequently not completely achieved. Regenerative techniques now in clinical use and at the translational research stage hold promise for custom-tailored constructs with the potential to regenerate tissue in the host without significant donor site morbidity. These techniques may provide better structure, aesthetics, and function than the best currently available options. This article presents the latest concepts in craniomaxillofacial regenerative medicine and reviews the multipronged approach to restoring architecture using novel "smart" multifunctional scaffolds, cellular technologies, growth factors, and other novel regenerative medical strategies. PMID:20159476

Costello, Bernard J; Shah, Gaurav; Kumta, Prashant; Sfeir, Charles S

2010-02-01

48

Mammalian regeneration and regenerative medicine  

Microsoft Academic Search

Mammals are generally considered to be poor regenerators, yet there are a handful of mammalian models that display a robust ability to regener- ate. One such system is the regenerating tips of digits in both humans and mice. In vitro studies of regenerating fetal human and mouse digit tips display both anatomical and molecular similarities, indicating that the mouse digit

Ken Muneoka; Christopher H. Allan; Xiaodong Yang; Jangwoo Lee; Manjong Han

2008-01-01

49

Regenerative Flywheel Energy Storage System.  

National Technical Information Service (NTIS)

The current status of a program to develop and evaluate a regenerative flywheel energy storage system is described. The system has been designed for a battery/flywheel electric vehicle in the 3000 pound class. Planned laboratory tests will simulate this e...

E. L. Lustenader I. H. Edelfelt D. W. Jones A. B. Plunkett E. Richter

1979-01-01

50

Regenerative Medicine: Past and Present  

Microsoft Academic Search

Novel therapies resulting from regenerative medicine and tissue engineering technology may offer new hope for patients with injuries, end-stage organ failure, degenerative disorders and many other clinical issues. Currently, patients suffering from diseased and injured organs are treated with transplanted organs. However, there is a shortage of donor organs that is worsening yearly as the population ages and new cases

Anthony Atala

2009-01-01

51

Regenerative Potential of Dental Pulp  

Microsoft Academic Search

The regenerative potential of dental pulp, particularly in mature teeth, has been considered extremely limited. However, our improved understanding of pulpal inflam- mation and repair and improved dental materials and technologies make vital pulp therapy a viable alterna- tive to root canal treatment. This article explores our knowledge in this regard and the future potential of saving or even regenerating

Martin Trope

52

Regenerative Engine Analysis Program (REAP).  

National Technical Information Service (NTIS)

This report presents the results of a 7-month program to conduct a preliminary design analysis of a 500-SHP fuel-efficient regenerative turboshaft engine and to identify promising heat-exchanger concepts for such engines. A technology level consistent wit...

R. W. Heldenbrand W. S. Miller

1981-01-01

53

Cardiac Regenerative Capacity and Mechanisms  

PubMed Central

The heart holds the monumental yet monotonous task of maintaining circulation. Although cardiac function is critical to other organs and to life itself, mammals are not equipped with significant natural capacity to replace heart muscle that has been lost by injury. This deficiency plays a role in leaving millions worldwide each year vulnerable to heart failure. By contrast, certain other vertebrate species like zebrafish are strikingly good at heart regeneration. A cellular and molecular understanding of endogenous regenerative mechanisms, combined with advances in methodology to transplant cells, together project a future in which cardiac muscle regeneration can be therapeutically stimulated in injured human hearts. This review will focus on what has been discovered recently about cardiac regenerative capacity and how natural mechanisms of heart regeneration in model systems are stimulated and maintained.

Kikuchi, Kazu; Poss, Kenneth D.

2013-01-01

54

Regenerative Wound Healing via Biomaterials  

Microsoft Academic Search

Regenerative tissue engineering has the potential to revolutionize reconstructive approaches by providing either prefabricated\\u000a tissue or responsive biomaterials with patient-specific geometry. The question to ask is how regeneration and repair are controlled\\u000a in vivo and if a responsive biomaterial system can drive these processes? Does the cellular control lie at the cell-biomaterial nano-interface\\u000a and do we have the tools to

Anshu B. Mathur

55

The unitized regenerative fuel cell  

SciTech Connect

Fuel cells can operate on hydrogen fuel and oxygen from air. If the fuel cell is designed to also operate in reverse as an electrolyzer, then electricity can be used to convert the water back into hydrogen and oxygen. This dual function system is known as a reversible or unitized regenerative fuel cell. This is an excellent energy source in situations where weight is a concern.

NONE

1997-05-01

56

Magnetic resonance imaging in hemifacial hyperplasia.  

PubMed

We describe a case of hemifacial hyperplasia due to a combination of lipoma and lipomatosis. The contribution of MRI to the diagnosis of hemifacial hyperplasia and to monitoring growth and development in this condition is demonstrated. PMID:11681487

Sugiyama, M; Tanaka, E; Ogawa, I; Ishibashi, R; Naito, K; Ishikawa, T

2001-07-01

57

Auricular angiolymphoid hyperplasia with eosinophilia.  

PubMed

Angiolymphoid hyperplasia with eosinophilia is an uncommon, benign, angioproliferative cutaneous disorder. Previously, angiolymphoid hyperplasia with eosinophilia and Kimura's disease were regarded as identical conditions, however, recent work identifies them as separate entities. It is clinically manifested by solitary or multiple, red to brown firm papules and nodules, occurring in the head and neck region with a predilection for the peri-auricular area. It usually occurs during the early and mid-adult life. It is more common in Caucasians with equal gender involvement. We report this condition in a 32 years old adult Pakistani male having red-brown papules in left ear. PMID:22015125

Rahman, Atiya; Asad Shabbir, Syed Muhammad; Tabassum, Saadia; Hafeez, Javeria

2011-10-01

58

The future of regenerative medicine: urinary system.  

PubMed

Regeneration of tissues and organs is now within the technological reach of modern medicine. With such advancements, substantial improvements to existing standards-of-care are very real possibilities. This review will focus on regenerative medicine approaches to treating specific maladies of the bladder and kidney, including the biological basis of regeneration and the history of regenerative medicine in the urinary system. Current clinical management approaches will be presented within the context of future directions including cell-based regenerative therapies. PMID:22070608

Ludlow, John W; Kelley, Russell W; Bertram, Timothy A

2011-12-22

59

Wavelength tunable alexandrite regenerative amplifier  

SciTech Connect

We describe a wavelength tunable alexandrite regenerative amplifier which is used to amplify nanosecond slices from a single-frequency cw dye laser or 50-ps pulses emitted by a diode laser to energies in the 10-mJ range. The amplified 5-ns slices generated by the cw-pumped line narrowed dye laser are Fourier transform limited. The 50-ps pulses emitted by a gain-switched diode laser are amplified by more than 10 orders of magnitude in a single stage.

Harter, D.J.; Bado, P.

1988-11-01

60

Regenerative heat recovery - its industrial applications  

Microsoft Academic Search

Regenerative heat recovery has many industrial applications such in VOC treatment of automobile painting booth. A generalized thermal regeneration process coupled with a process and a pre-process was reviewed. Heat transfer and energy balance of the processes were analyzed and heat gain in the cycles is presented with relation to the efficiency of the regenerator. Applications in regenerative thermal oxidizer

Aruna S. K. Warahena; Yew Khoy Chuah

2007-01-01

61

Potential of endogenous regenerative technology for in situ regenerative medicine.  

PubMed

Endogenous regenerative technology (Endoret) involves the use of patient's own biologically active proteins, growth factors and biomaterial scaffolds for therapeutic purposes. This technology provides a new approach for the stimulation and acceleration of tissue healing and bone regeneration. The versatility and biocompatibility of using patient-derived fibrin scaffold as an autologous, biocompatible and biodegradable drug delivery system open the door to a personalized medicine that is currently being used in numerous medical and scientific fields including dentistry, oral implantology, orthopaedics, ulcer treatment, sports medicine and tissue engineering among others. This review discusses the state of the art and new directions in the use of endogenous technology in the repair and regeneration of injured tissues by means of a controlled and local protein and growth factor delivery. The next generations of engineering strategies together with some of the most interesting therapeutic applications are discussed together with the future challenges in the field. PMID:20102730

Anitua, Eduardo; Sánchez, Mikel; Orive, Gorka

2010-01-25

62

Atypical lymphoid hyperplasia mimicking lymphoma.  

PubMed

The distinction between reactive and neoplastic lymphoid infiltrates is a common problem in clinical practice and can be problematic. The clinical implications for both the patient and the treating clinician are profound. In this article, we discuss six of the common entities that can present as atypical lymphoid hyperplasia and thus can mimic malignant lymphomas, with emphasis on morphologic features, immunophenotypic findings, and molecular correlates that help distinguish these disorders from neoplastic conditions. The six conditions to be discussed in detail include reactive follicular hyperplasia versus follicular lymphoma; progressive transformation of germinal centers versus nodular lymphocyte predominant Hodgkin lymphoma; immunoblastic proliferations versus diffuse large B-cell lymphomas; variant forms of Castleman disease that may mimic a number of lymphoid cancers; Kikuchi's disease versus large cell lymphomas; and finally, dermatopathic lymphadenopathy and its distinction from lymph nodes showing early involvement by cutaneous T-cell lymphoma (Mycosis fungoides). PMID:19577167

Good, David J; Gascoyne, Randy D

2009-08-01

63

Variable ratio regenerative braking device  

DOEpatents

Disclosed is a regenerative braking device (10) for an automotive vehicle. The device includes an energy storage assembly (12) having a plurality of rubber rollers (26, 28) mounted for rotation between an input shaft (36) and an output shaft (42), clutches (38, 46) and brakes (40, 48) associated with each shaft, and a continuously variable transmission (22) connectable to a vehicle drivetrain and to the input and output shafts by the respective clutches. The rubber rollers are torsionally stressed to accumulate energy from the vehicle when the input shaft is clutched to the transmission while the brake on the output shaft is applied, and are torsionally relaxed to deliver energy to the vehicle when the output shaft is clutched to the transmission while the brake on the input shaft is applied. The transmission ratio is varied to control the rate of energy accumulation and delivery for a given rotational speed of the vehicle drivetrain.

Hoppie, Lyle O. (Birmingham, MI)

1981-12-15

64

Unitized regenerative fuel cell systems  

SciTech Connect

Energy storage systems with extremely high specific energy (>400 Wh/kg) have been designed that use lightweight pressure vessels to contain the gases generated by reversible (unitized) regenerative fuel cells (URFCs).[1] URFC systems are being designed and developed for a variety of applications, including high altitude long endurance (HALE) solar rechargeable aircraft (SRA), zero emission vehicles (ZEVs), hybrid energy storage/propulsion systems for spacecraft, energy storage for remote (off-grid) power sources, and peak shaving for on-grid applications.[1-10] Energy storage for HALE SRA was the original application for this set of innovations, and a prototype solar powered aircraft (Pathfinder-Plus) recently set another altitude record for all propeller-driven aircraft on August 6, 1998, when it flew to 80,285 feet (24.47 km).[11

Mitlitsky, F; Molter, T M; Myers, B; Weisberg, A H

1998-09-10

65

Lipomatosis: a diverse form of hemifacial hyperplasia  

PubMed Central

A case of hemifacial hyperplasia that presented with muscular, skeletal, and dental hyperplasia along with lipomatous infiltration was described. Advanced imaging was useful in identifying the lipomatous infiltration present in the lesion, which raises the possibility of lipomatosis having a diverse presentation in hemifacial hyperplasia. As there was a scarcity of related literature in the field of dentomaxillofacial radiology, this report would make us familiar with its computed tomographic and magnetic resonance image findings.

Umarji, Hemant R.; Arora, Aman; Ramaswami, Easwaran

2012-01-01

66

Medical treatment of benign prostatic hyperplasia  

PubMed Central

Pharmaceutical preparations are commonly used for benign prostate hyperplasia. This article reviews the current understanding of the natural history of the condition and the literature regarding medical treatment.

Connolly, Stephen S; Fitzpatrick, John M

2007-01-01

67

Reflective Self-Regenerative Systems Architecture Study.  

National Technical Information Service (NTIS)

In this study, we develop the Reflective Self-Regenerative Systems (RSRS) architecture in detail, describing the internal structure of each component and the mutual invocations among the components. The main goal of RSRS architecture is a conceptually sim...

C. Pu D. Blough

2006-01-01

68

Stored Energy Management for Regenerative Braking Applications.  

National Technical Information Service (NTIS)

The use of regenerative braking devices to conserve energy during repeated speed changes of vehicles is well known. Practical systems based on electrical energy storage in batteries and kinetic energy storage in flywheels have been developed to the commer...

F. M. Russell

1983-01-01

69

ReGen Collagen Scaffold (CS)  

Center for Biologics Evaluation and Research (CBER)

Text VersionPage 1. ReGen Collagen Scaffold (CS) Diana Zuckerman, Ph.D. President ... than nothing Page 17. Diana Zuckerman, Ph.D. President ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

70

Unitized Regenerative Fuel Cell System Development.  

National Technical Information Service (NTIS)

Unitized Regenerative Fuel Cells (URFC) have recently been developed by several fuel cell manufacturers. These manufacturers have concentrated their efforts on the development of the cell stack technology itself, and have not up to this point devoted much...

K. A. Burke

2003-01-01

71

Regenerative medicine: a primer for paediatricians.  

PubMed

Regenerative medicine is a multidisciplinary field concerned with the replacement, repair or restoration of injured tissues. Cell therapy and tissue engineering are part of the broader remit of regenerative medicine. The ultimate aim is to provide safe and efficient therapies for a large number of clinical conditions. Novel regenerative therapies are already in use in initial clinical trials. The main components of regenerative medicine are cells and specially designed materials. A vast variety of cells types are currently used including: adult and stem cells. Equally a large number of natural and man-made materials have been investigated. Despite of considerable advances many challenges lie ahead. These are summarised in this review article. The field is slowly maturing and the initial unhelpful hype has been replaced by a more measured, mature and realistic outlook. PMID:19783108

Polak, Dame Julia M

2009-09-27

72

Sources of Stem Cells for Regenerative Medicine  

Microsoft Academic Search

The shortage of organ donors for regenerative medicine has stimulated research on stem cells as a potential resource for cell-based\\u000a therapy. Stem cells have been used widely for regenerative medicine applications. The development of innovative methods to\\u000a generate stem cells from different sources suggests that there may be new alternatives for cell-based therapies. Here, we\\u000a provide an overview of human

Jennifer Hipp; Anthony Atala

2008-01-01

73

Stem Cells in Regenerative Medicine  

PubMed Central

Background: A number of cardiovascular, neurological, musculoskeletal and other diseases have a limited capacity for repair and only a modest progress has been made in treatment of brain diseases. The discovery of stem cells has opened new possibilities for the treatment of these maladies, and cell therapy now stands at the cutting-edge of modern regenerative medicine and tissue engineering. Experimental data and the first clinical trials employing stem cells have shown their broad therapeutic potential and have brought hope to patients suffering from devastating pathologies of different organs and systems. Aims: Here, we briefly review the main achievements and trends in cell-based therapy, with an emphasis on the main types of stem cells: embryonic, mesenchymal stromal and induced pluripotent cells. Discussion: Many questions regarding the application of stem cells remain unanswered, particularly tumorigenicity, immune rejection and danger of gene manipulation. Currently, only MSC seems to be safe and might be considered to be a leading candidate for human application to treat pathologies that affect the cardiovascular, neurological and musculoskeletal systems.

Sykova, Eva; Forostyak, Serhiy

2013-01-01

74

Congenital adrenal hyperplasia and pregnancy.  

PubMed

A 32-year-old woman with classical congenital adrenal hyperplasia (CAH) secondary to 21-hydroxylase deficiency presented with infertility. She was treated with different steroid replacement regimens together with fludrocortisone. The aim of this case report is to discuss fertility barriers in women with classical CAH, and emphasise the risks and benefits of available steroid treatment options. Clinical considerations covered include preconception health and fertility planning, optimising fertility through suppression of excess hormone production, reducing fetal androgen exposure in utero and limiting maternal and fetal side effects of therapy and limiting chances of CAH in the baby. In this case suppression of androgen and progesterone levels was challenging but eventually was achieved and resulted in a spontaneous pregnancy. However, she miscarried in the first trimester, and fetal biopsy revealed a complete hydatiform mole. She is advised not to conceive while she is under investigation to determine the extent of the disease. PMID:23917362

Shorakae, Soulmaz; Teede, Helena

2013-08-05

75

Focal epithelial hyperplasia - an update.  

PubMed

Focal epithelial hyperplasia (FEH) is an asymptomatic benign mucosal disease, which is mostly observed in specific groups in certain geographical regions. FEH is usually a disease of childhood and adolescence and is generally associated with people who live in poverty and of low socioeconomic status. Clinically, FEH is typically characterized by multiple, painless, soft, sessile papules, plaques or nodules, which may coalesce to give rise to larger lesions. Human papillomavirus (HPV), especially genotypes 13 and 32, have been associated and detected in the majority of FEH lesions. The clinical examination and social history often allow diagnosis, but histopathological examination of lesional tissue is usually required to confirm the exact diagnosis. FEH sometimes resolves spontaneously however, treatment is often indicated as a consequence of aesthetic effects or any interference with occlusion. There remains no specific therapy for FEH, although surgical removal, laser excision or possibly topical antiviral agents may be of benefit. There remains no evidence that FEH is potentially malignant. PMID:23061874

Said, Ahmed K; Leao, Jair C; Fedele, Stefano; Porter, Stephen R

2012-10-14

76

Combined hydraulic and regenerative braking system  

DOEpatents

A combined hydraulic and regenerative braking system and method for an electric vehicle, with the braking system being responsive to the applied hydraulic pressure in a brake line to control the braking of the vehicle to be completely hydraulic up to a first level of brake line pressure, to be partially hydraulic at a constant braking force and partially regenerative at a linearly increasing braking force from the first level of applied brake line pressure to a higher second level of brake line pressure, to be partially hydraulic at a linearly increasing braking force and partially regenerative at a linearly decreasing braking force from the second level of applied line pressure to a third and higher level of applied line pressure, and to be completely hydraulic at a linearly increasing braking force from the third level to all higher applied levels of line pressure.

Venkataperumal, Rama R. (Troy, MI); Mericle, Gerald E. (Mount Clemens, MI)

1981-06-02

77

Enhanced external counterpulsation is a regenerative therapy.  

PubMed

Enhanced external counterpulsation (EECP) is used for the treatment of severe angina and heart failure in patients who are not candidates for revascularization. The clinical benefits of EECP extend well beyond the time period of any hemodynamic effects, but the cause of this prolonged effect is not understood. The prolonged clinical benefits suggest EECP could be a regenerative therapy. This study was performed to determine whether EECP increased circulating hematopoietic progenitor cells (HPCs) or endothelial progenitor cells (EPCs) and thus be a possible regenerative therapy. The proposed mechanism of the increase in regenerative circulating stem cells is the enhanced shear forces induced on the endothelial boundary by the flow reversal produced by the sequential inflation of the pneumatic cuffs during EECP therapy. PMID:20036860

Jewell, Coty W; Houck, Philip D; Watson, Linley E; Dostal, David E; Dehmer, Gregory J

2010-01-01

78

Combined hydraulic and regenerative braking system  

DOEpatents

A combined hydraulic and regenerative braking system and method for an electric vehicle is disclosed. The braking system is responsive to the applied hydraulic pressure in a brake line to control the braking of the vehicle to be completely hydraulic up to a first level of brake line pressure, to be partially hydraulic at a constant braking force and partially regenerative at a linearly increasing braking force from the first level of applied brake line pressure to a higher second level of brake line pressure, to be partially hydraulic at a linearly increasing braking force and partially regenerative at a linearly decreasing braking force from the second level of applied line pressure to a third and higher level of applied line pressure, and to be completely hydraulic at a linearly increasing braking force from the third level to all higher applied levels of line pressure.

Venkataperumal, R.R.; Mericle, G.E.

1979-08-09

79

Functionalized Nanostructures with Application in Regenerative Medicine  

PubMed Central

In the last decade, both regenerative medicine and nanotechnology have been broadly developed leading important advances in biomedical research as well as in clinical practice. The manipulation on the molecular level and the use of several functionalized nanoscaled materials has application in various fields of regenerative medicine including tissue engineering, cell therapy, diagnosis and drug and gene delivery. The themes covered in this review include nanoparticle systems for tracking transplanted stem cells, self-assembling peptides, nanoparticles for gene delivery into stem cells and biomimetic scaffolds useful for 2D and 3D tissue cell cultures, transplantation and clinical application.

Peran, Macarena; Garcia, Maria A.; Lopez-Ruiz, Elena; Bustamante, Milan; Jimenez, Gema; Madeddu, Roberto; Marchal, Juan A.

2012-01-01

80

Collagen scaffolds for orthopedic regenerative medicine  

NASA Astrophysics Data System (ADS)

Collagen and collagen-based scaffolds offer distinct advantages when selected as biomaterials for use across a broad spectrum of regenerative medicine applications. However, relatively poor mechanical properties are often perceived to limit their usefulness for orthopedic applications. These problems can be overcome through enhanced crosslinking mechanisms or through the addition of a second, stiffer phase such as hydroxyapatite, thus allowing tailored composite scaffolds to meet specific tissue requirements. This overview will highlight the current state of the art of these scaffolds, and consider the exciting prospects and future directions of collagen-based technologies for orthopedic regenerative medicine.

Cunniffe, Gráinne M.; O'Brien, Fergal J.

2011-04-01

81

Regenerative therapy: a periodontal-endodontic perspective.  

PubMed

Periodontal and endodontic diseases are inflammatory responses leading to periodontal and pulpal tissue loss. Regenerative therapies aim to restore the lost structures to vitality and function. Various materials and treatments methods have been used such as bone grafts, guided tissue regeneration, enamel matrix derivatives, growth and differentiation factors, and stem cells. Although the current materials and methods demonstrated adequate clinical results, true and complete biological tissue regeneration is not yet attainable. The current article reviews chronologically the materials and methods used in periodontal and endodontic regeneration highlighting their clinical success and shortcomings, and discussing future directions in regenerative therapy. PMID:22835536

Kinaia, Bassam Michael; Chogle, Sami M A; Kinaia, Atheel M; Goodis, Harold E

2012-06-23

82

WIDE BAND REGENERATIVE FREQUENCY DIVIDER AND MULTIPLIER  

DOEpatents

A regenerative frequency divider and multiplier having wide band input characteristics is presented. The circuit produces output oscillations having frequencies related by a fixed ratio to input oscillations over a wide band of frequencies. In accomplishing this end, the divider-multiplier includes a wide band input circuit coupled by mixer means to a wide band output circuit having a pass band related by a fixed ratio to that of the input circuit. A regenerative feedback circuit derives a fixed frequency ratio feedback signal from the output circuit and applies same to the mixer means in proper phase relation to sustain fixed frequency ratio oscillations in the output circuit.

Laine, E.F.

1959-11-17

83

ReGen Biologics, Inc. Collagen Scaffold (CS)  

Center for Biologics Evaluation and Research (CBER)

Text Version... ReGen Biologics, Inc. Collagen Scaffold (CS) Page 2. 2 ... 12 Comparing the Use of Rotator Cuff Surgical Meshes with the ReGen Collagen Scaffold ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

84

Fetal thyroid hyperplasia, rhesus isoimmunisation, and amniography.  

PubMed Central

Thyroid hyperplasia was identified at necropsy in 16 of 70 cases of haemolytic disease of the newborn due to rhesus isoimmunisation dying in the years 1959--76. No hyperplasia was found in the thyroids from 140 nonrhesus-affected infants matched for date of birth, bodyweight and length, and gestation, or in cases of haemolytic disease born before 1966. All 16 infants with thyroid hyperplasia had received intrauterine transfusions and the iodine-containing contrast media used for preliminary amniography were the only goitrogenic factors identified. Lipiodol, first used in 1966, was considered to have the greatest effect. The 16 infants with hyperplastic thyroids were less mature and smaller than 22 infants with normal thyroids who had been similarly exposed to contrast media. The high incidence of hyperplasia may be due to immaturity of the adaptive mechanisms which allow most normal individuals to escape the goitrogenic effects of iodine compounds. Images Fig. 1

Becroft, D M; Smeeton, W M; Stewart, J H

1980-01-01

85

Throid Hyperplasia at Autopsy in Mulago Hospital.  

National Technical Information Service (NTIS)

Thyroid hyperplasia was found in 89 per cent of unselected autopsy cases at Mulago Hospital. This reflects a low intake of dietary iodine. The number of tribes involved indicates that this is a widespread problem in Uganda. (Author)

D. H. Connor R. H. Follis

1965-01-01

86

An Almost Regenerative Simulation of Video Teleconferencing Traffic  

Microsoft Academic Search

This note discusses the application of an almost regenerative method to the simulation of a Markov chain that takes a very long time to converge. Even simulation runs of cells did not produce the same results for simulation scenarios with an average cellloss-rate of The regenerative method can not be used here as the time between regenerative states is too

David M. Cohen; Daniel P. Heyman

1993-01-01

87

Anhydrous Hâ\\/Clâ regenerative fuel cell  

Microsoft Academic Search

A regenerative fuel cell is described in which the reactive gases are hydrogen and chlorine and the electrolyte is a conductive anhydrous solvent in which the chlorine gas and the hydrogen chloride gas are soluble, this electrolyte readily releasing the gaseous hydrogen chloride for storage during discharge of the cell.

Maricle

1978-01-01

88

Regenerative nanomedicine: ethical, legal, and social issues.  

PubMed

Advances in regenerative nanomedicine raise a host of ethical, legal, and social questions that healthcare providers and scientists will need to consider. These questions and concerns include definitions, appropriate applications, dual use, potential risks, regulations, and access. In this chapter, we provide an overview of the questions and concerns and recommend proactive consideration and solutions. PMID:22042687

Glenn, Linda MacDonald; Boyce, Jeanann S

2012-01-01

89

Advanced Regenerative Life Support for Space Exploration.  

National Technical Information Service (NTIS)

Advanced regenerative Environmental Control and Life Support System (ECLSS) technology was identified by NASA as enabling for space exploration. Low Earth Orbit (LEO) mass savings of over 700,000 pounds (320,000 kg) per year are expected for a lunar outpo...

H. T. Couch J. W. Auman T. C. Falvey

1991-01-01

90

Triacs in Reversible Regenerative DC Motor Drives  

Microsoft Academic Search

This paper presents a triac converter which can replace two thyristor bridges normally used for regenerative dc motor drives. The most important characteristics of the triac are outlined and specific problems are discussed. Performance specifications for the control electronics are given. An experimental drive is presented and some run measurements are shown.

Henry B. Raphael; Asle Skjellnes

1973-01-01

91

Kilohertz Femtosecond Ti: Sapphire Regenerative Amplifier.  

National Technical Information Service (NTIS)

To have capabilities in the near-infrared, we proposed to develop a Ti:S regenerative amplifier operating at one kilohertz. This amplifier was developed to amplify the pulses from our femtosecond Ti:S laser oscillator to the 2-3 mu J/pulse energy level. T...

N. Peyghamberian B. McGinnis

1995-01-01

92

Regenerative medicine of the pancreatic ? cells  

Microsoft Academic Search

Diabetes mellitus is a metabolic disorder that affects millions of people. The number of patients suffering from diabetes continues to increase all over the world. Both type 1 and type 2 diabetes result from an inadequate mass of functioning ß cells. To achieve the ultimate goal of curing diabetes in the future, the mechanism of the regenerative process of the

Satoko Yamada; Itaru Kojima

2005-01-01

93

Integrated regenerative fuel cell experimental evaluation  

Microsoft Academic Search

An experimental test program was conducted to investigate the performance characteristics of an integrated regenerative fuel cell (IRFC) concept. The IRFC consists of a separate fuel cell unit and electrolysis cell unit in the same structure, with internal storage of fuel cell product water and external storage of electrolysis cell produced hydrogen and oxygen. The fuel cell unit incorporates an

Ronald E. Martin

1990-01-01

94

[Tissue engineered skin and regenerative wound repair].  

PubMed

Various skin defects resulting from mechanical injury, burns, chronic ulcers, and resection of tumor etc. are very common in clinic. The traditional treatment measure, such as grafting of autologous split-thickness skin remains the gold standard. However, its limitations are obvious, such as shortage of donor sites, creation of new injury, and scar formation. To realize regenerative or scarless repair of tissue defects has always been the dream of human being. The advent of tissue engineered skin (TES) provides an ideal access to tissue regeneration. After decades of development, several kinds of TES products have been developed and used in clinic, with promising effects. However, a large number of basic scientific problems regarding TES, as well as difficulties in translation of basic research to bedside should be taken into serious consideration. This article presents a comprehensive overview of strategies of construction of TES, the role of TES in regenerative wound repair, and its opportunities and challenges. PMID:23985197

Han, Chun-mao; Wang, Xin-gang

2013-04-01

95

MicroRNAs and regenerative medicine.  

PubMed

MicroRNAs, identified only relatively recently, are regulators of gene expression with potential medical benefits. The combination of microRNAs and regenerative medicine is an emerging interdisciplinary medical field that can yield exciting new possibilities for clinical medicine. In this paper, we review the prospects of microRNAs as future therapies in regenerative medicine. Recently, researchers have demonstrated the crucial roles of microRNAs, not only in the differentiation and proliferation of stem cells, which have a key function in the regeneration and transplantation of organs, but also in oncogenesis. Several lines of indirect evidence show that the initiation and maintenance of cancer stem cells might also be under the control of microRNAs. Further, microRNAs have been indicated to be involved in diverse biological processes, suggesting the potential role of these molecules in the treatment of diseases. PMID:17465892

Yang, Zhaojuan; Wu, Ji

2007-04-01

96

Regenerative cells for transplantation in hepatic failure.  

PubMed

Human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells have an enormous potential; however, their potential clinical application is being arrested due to various limitations such as teratoma formation followed by tumorigenesis, emergent usage, and the quality control of cells, as well as safety issues regarding long-term culture are also delaying their clinical application. In addition, human ES cells have two crucial issues: immunogenicity and ethical issues associated with their clinical application. The efficient generation of human iPS cells requires gene transfer, yet the mechanism underlying pluripotent stem cell induction has not yet been fully elucidated. Otherwise, although human adult regenerative cells including mesenchymal stem cells have a limited capacity for differentiation, they are nevertheless promising candidates for tissue regeneration in a clinical setting. This review highlights the use of regenerative cells for transplantation in hepatic failure. PMID:22793046

Ishikawa, Tetsuya; Banas, Agnieszka; Teratani, Takumi; Iwaguro, Hideki; Ochiya, Takahiro

2012-01-01

97

Regenerative nanomedicines: an emerging investment prospective?  

PubMed

Cells respond to their structural surrounding and within nanostructures exhibit unique proliferative and differentiation properties. The application of nanotechnologies to the field of regenerative medicine offers the potential to direct cell fate, target the delivery of cells and reduce immune rejection (via encapsulation), thereby supporting the development of regenerative medicines. The overall objective of any therapy is the delivery of the product not just into the clinic but also to patients on a routine basis. Such a goal typically requires a commercial vehicle and substantial levels of investment in scientific, clinical, regulatory and business expertise, resources, time and funding. Therefore, this paper focuses on some of the challenges facing this emerging industry, including investment by the venture capital community. PMID:20826478

Prescott, Catherine

2010-09-08

98

Short wavelength regenerative amplifier free electron lasers  

NASA Astrophysics Data System (ADS)

In this paper we discuss extending the operating wavelength range of tunable Regenerative Amplifier FELs to shorter wavelengths than current design proposals, notably into the XUV regions of the spectrum and beyond where the reflectivity of broadband optics is very low. Simulation studies are presented which demonstrate the development of good temporal coherence in generic systems with a broadband radiation feedback of less than one part in ten thousand.

Dunning, D. J.; McNeil, B. W. J.; Thompson, N. R.

2008-08-01

99

Design Peptide Scaffolds for Regenerative Medicine  

Microsoft Academic Search

\\u000a Regenerative and reparative medicine require two key complementary ingredients: the biological scaffolds and stem cells, both\\u000a embryonic and adult stem cells. Designs of new scaffolds at the molecular level have become increasingly important for such\\u000a an endeavor. New technology through molecular self-assembly as a fabrication tool will become integral part of new medicine\\u000a in the coming years. We are inspired

Shuguang Zhang; Carlos E. Semino

100

Low-temperature thermally regenerative electrochemical system  

DOEpatents

A thermally regenerative electrochemical system is described including an electrochemical cell with two water-based electrolytes separated by an ion exchange membrane, at least one of the electrolytes containing a complexing agent and a salt of a multivalent metal whose respective order of potentials for a pair of its redox couples is reversible by a change in the amount of the ocmplexing agent in the electrolyte, the complexing agent being removable by distillation to cause the reversal.

Loutfy, R.O.; Brown, A.P.; Yao, N.P.

1982-04-21

101

Low temperature thermally regenerative electrochemical system  

DOEpatents

A thermally regenerative electrochemical system including an electrochemical cell with two water-based electrolytes separated by an ion exchange membrane, at least one of the electrolytes containing a complexing agent and a salt of a multivalent metal whose respective order of potentials for a pair of its redox couples is reversible by a change in the amount of the complexing agent in the electrolyte, the complexing agent being removable by distillation to cause the reversal.

Loutfy, Raouf O. (Tucson, AZ); Brown, Alan P. (Bolingbrook, IL); Yao, Neng-Ping (Clarendon Hills, IL)

1983-01-01

102

Regenerative Chimerism Bioengineered Through Stem Cell Reprogramming  

Microsoft Academic Search

\\u000a Regenerative medicine aims to restore damaged tissues in order to reverse disease progression and provide a sustainable solution\\u000a that cures the root cause of the disease process. Although natural mechanisms of repair are ubiquitous, disruption of the\\u000a homeostatic balance affects the equilibrium between health and disease due to insufficient tissue renewal in chronic degenerative\\u000a conditions. Augmentation of the diseased tissue

Timothy J. Nelson; Almudena Martinez-Fernandez; Satsuki Yamada; Andre Terzic

103

Regenerative Hydrogen-Oxygen Fuel Cell  

Microsoft Academic Search

The regenerative hydrogen-oxygen ion-exchange membrane fuel cell is especially suitable for use in space power systems. During discharge, the anode reaction is H2+20H-¿2H2O+2e. The electrons pass out of the fuel cell at the anode to the load, then re-enter at the cathode. The cathode reaction is ½02+H2O+2e ¿20H-. The hydroxyl ions pass through the membrane to the anode; the electrical

S. E. Voltz; M. D. Read

1962-01-01

104

Stem cell platforms for regenerative medicine.  

PubMed

The pandemic of chronic degenerative diseases associated with aging demographics mandates development of effective approaches for tissue repair. As diverse stem cells directly contribute to innate healing, the capacity for de novo tissue reconstruction harbors a promising role for regenerative medicine. Indeed, a spectrum of natural stem cell sources ranging from embryonic to adult progenitors has been recently identified with unique characteristics for regeneration. The accessibility and applicability of the regenerative armamentarium has been further expanded with stem cells engineered by nuclear reprogramming. Through strategies of replacement to implant functional tissues, regeneration to transplant progenitor cells or rejuvenation to activate endogenous self-repair mechanisms, the overarching goal of regenerative medicine is to translate stem cell platforms into practice and achieve cures for diseases limited to palliative interventions. Harnessing the full potential of each platform will optimize matching stem cell-based biologics with the disease-specific niche environment of individual patients to maximize the quality of long-term management, while minimizing the needs for adjunctive therapy. Emerging discovery science with feedback from clinical translation is therefore poised to transform medicine offering safe and effective stem cell biotherapeutics to enable personalized solutions for incurable diseases. PMID:19779576

Nelson, Timothy J; Behfar, Atta; Yamada, Satsuki; Martinez-Fernandez, Almudena; Terzic, Andre

2009-06-01

105

Stem Cell Platforms for Regenerative Medicine  

PubMed Central

The pandemic of chronic degenerative diseases associated with aging demographics mandates development of effective approaches for tissue repair. As diverse stem cells directly contribute to innate healing, the capacity for de novo tissue reconstruction harbors a promising role for regenerative medicine. Indeed, a spectrum of natural stem cell sources ranging from embryonic to adult progenitors has been recently identified with unique characteristics for regeneration. The accessibility and applicability of the regenerative armamentarium has been further expanded with stem cells engineered by nuclear reprogramming. Through strategies of replacement to implant functional tissues, regeneration to transplant progenitor cells or rejuvenation to activate endogenous self-repair mechanisms, the overarching goal of regenerative medicine is to translate stem cell platforms into practice and achieve cures for diseases limited to palliative interventions. Harnessing the full potential of each platform will optimize matching stem cell-based biologics with the disease-specific niche environment of individual patients to maximize the quality of long-term management, while minimizing the needs for adjunctive therapy. Emerging discovery science with feedback from clinical translation is therefore poised to transform medicine offering safe and effective stem cell biotherapeutics to enable personalized solutions for incurable diseases.

Nelson, Timothy J.; Behfar, Atta; Yamada, Satsuki; Martinez-Fernandez, Almudena; Terzic, Andre

2009-01-01

106

Researches on regenerative medicine-current state and prospect.  

PubMed

Since 1980s, the rapid development of tissue engineering and stem cell research has pushed regenerative medicine to a new fastigium, and regenerative medicine has become a noticeable research field in the international biology and medicine. In China, about 100 million patients need repair and regeneration treatment every year, while the number is much larger in the world. Regenerative medicine could provide effective salvation for these patients. Both Chinese Academy of Sciences and Chinese Academy of Engineering have made roadmaps of 2010-2050 and 2011-2030 for regenerative medicine. The final goal of the two roadmaps is to make China go up to leading position in most research aspects of regenerative medicine. In accord with this strategy, the government and some enterprises have invested 3-5 billion RMB (0.5-0.8 billion USD) for the research on regenerative medicine. In order to push the translation of regenerative medicine forward-from bench to bedside, a strategic alliance has been established, and it includes 27 top-level research institutes, medical institutes, colleges, universities and enterprises in the field of stem cell and regeneration medicine. Recently the journal, Science, has published a special issue-Regenerative Medicine in China, consisting of 35 papers dealing with stem cell and regeneration, tissue engineering and regeneration, trauma and regeneration and bases for tissue repair and regenerative medicine. It is predicated that a greater breakthrough in theory and practice of regenerative medicine will be achieved in the near future (20 to 30 years). PMID:23069095

Wang, Zheng-Guo; Xiao, Kai

2012-10-01

107

Structural characterization of [(?-H)Os 3(CO) 10(?-NH 2)] and a new polymorphic form of [(?-H)Os 3(CO) 10(?-SH)]. Influence of the bridging group on the geometry of compounds [(?-H)Os 3(CO) 10(?-X)] (X = NH 2, NRH, PRH, SbR 2, OH, SH, SR, SeR, Cl, Br). Reactions of [(?-H)Os 3(CO) 10(?-X)] (X = OH and SH) with proton sponge  

Microsoft Academic Search

Compounds [(?-H)Os3(CO)10(?-NH2)] and a new polymorphic form of [(?-H)Os3(CO)10(?-SH)] were obtained from the reaction of [H2Os3(CO)10] with 1,3,5-N,N,N,-trimethyl-triazinane and 1,3,5-trithiane respectively. The structures show the same geometry described for other doubly bridged triangular clusters. A comparison of these type of compounds show that the bridging group does not affect significantly the dihedral angle between Os3 and Os2X planes (X=NH2, NRH,

Ottmar R. Reyes-López; Marco A. Leyva; María J. Rosales-Hoz

2011-01-01

108

Efficient tumorigenesis by mutation-induced failure to terminate microRNA-mediated adaptive hyperplasia.  

PubMed

Seven current contending cancer theories consider different sets of critical events as sufficient for tumorigenesis. These theories, most recently the microRNA dysregulation (MRD) theory, have overlapping attributes and extensive empirical support, but also some discrepancies, and some do not address both benign and malignant tumorigenesis. By definition, the most efficient tumorigenic pathways will dominate under conditions that selectively activate those pathways. The MRD theory provides a mechanistic basis to combine elements of the current theories into a new hypothesis that: (i) tumors arise most efficiently under stress that induces and sustains either protective or regenerative states of adaptive hyperplasia (AH) that normally are epigenetically maintained unless terminated; and (ii) if dysregulated by a somatic mutation that prevents normal termination, these two AH states can generate benign and malignant tumors, respectively. This hypothesis, but not multistage cancer theory, predicts that key participating AH-stem-cell populations expand markedly when triggered by stress, particularly chronic metabolic or oxidative stress, mechanical irritation, toxic exposure, wounding, inflammation, and/or infection. This hypothesis predicts that microRNA expression patterns in benign vs. malignant tumor tissue will correlate best with those governing protective vs. regenerative AH in that tissue, and that tumors arise most efficiently inmutagen-exposed stem cells that either happen to be in, or incidentally later become recruited into, an AH state. PMID:23183421

Bogen, Kenneth T

2012-11-24

109

Regenerative pulse shaping and amplification of ultrabroadband optical pulses  

Microsoft Academic Search

Regenerative pulse shaping is used to alleviate gain narrowing during ultrashort-pulse amplification. Amplification bandwidths of â¼100 nm, or nearly three times wider than the traditional gain-narrowing limit, are produced with a modified Ti:sapphire regenerative amplifier. This novel regenerative amplifier has been used to amplify pulses to the 5-mJ level with a bandwidth sufficient to support â¼10-fs pulses. {copyright} {ital 1996

C. P. J. Barty; G. Korn; F. Raksi; C. Rose-Petruck; Jeff Squier; A.-C. Tien; K. R. Wilson; V. V. Yakovlev; K. Yamakawa

1996-01-01

110

Prostatic Hyperplasia: An Unknown Feature of Acromegaly  

Microsoft Academic Search

This study was designed to investigate whether GH and insulin- like growth factor I (IGF-I) excess could lead to the development of benign prostatic hyperplasia and\\/or prostatic carcinoma. Prostatic diameters and volume as well as the occurrence of prostatic diseases were studied by ultrasonography in 10 untreated acromegalic pa- tients less than 40 yr of age and 10 age- and

PAOLO MARZULLO; DIEGO FERONE; STEFANO SPIEZIA; GAETANA CERBONE; VALERIA MARINO; ANTONELLA DI SARNO; BARTOLOMEO MEROLA; GAETANO LOMBARDI

1998-01-01

111

Macroorchidism: consequence of untreated congenital adrenal hyperplasia.  

PubMed

Testicular adrenal rest tumors (TART) are consequences of delayed diagnosis and/or undertreatment in patients with congenital adrenal hyperplasia (CAH). We describe a case of CAH with TART who presented with bilateral macroorchidism. He was managed with glucocorticoids which led to decrease in testicular size without restoration of spermatogenesis. PMID:22885440

Rastogi, Ashu; Walia, Rama; Saikia, Uma Nahar; Bhansali, Anil

2012-07-01

112

Neointimal hyperplasia associated with synthetic hemodialysis grafts  

Microsoft Academic Search

Stenosis is a major cause of failure of hemodialysis vascular grafts and is primarily caused by neointimal hyperplasia (NH) at the anastomoses. The objective of this article is to provide a scientific review of the biology underlying this disorder and a critical review of the state-of-the-art investigational preventive strategies in order to stimulate further research in this exciting area. The

Li Li; Christi M Terry; Yan-Ting E Shiu; Alfred K Cheung

2008-01-01

113

Adult Consequences of Congenital Adrenal Hyperplasia  

Microsoft Academic Search

Background: Congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency accounts for 95% of all CAH cases and is one the most common inborn metabolic disorders. While consensus and guidelines on therapeutic management in infancy and childhood are available, data regarding the treatment of adults with CAH are scarce. This review highlights the issues that need to be addressed when caring

Wiebke Arlt; Nils Krone

2007-01-01

114

Bacillary angiomatosis associated with pseudoepitheliomatous hyperplasia.  

PubMed

Bacillary angiomatosis is an opportunistic bacterial infection caused by either Bartonella henselae or B. quintana. The classic histologic presentation of bacillary angiomatosis involves three components: a lobular proliferation of capillaries with enlarged endothelial cells, neutrophilic debris, and clumps of finely granular material identified as bacteria with staining techniques. Pseudoepitheliomatous hyperplasia is a histologic reaction pattern characterized by epithelial proliferation in response to a variety of stimuli, including mycobacterial, fungal, and bacterial infections. We describe a case of bacillary angiomatosis associated with pseudoepitheliomatous hyperplasia in an immunocompromised patient with Acquired Immunodeficiency Syndrome. Histologic examination of a finger lesion demonstrated a capillary proliferation with neutrophilic debris and characteristic amorphous granular deposits. Warthin-Starry and Giemsa staining revealed clumps of coccobacilli. Cervical lymph node tissue also revealed organisms identified as Bartonella with PCR techniques. Stains and cultures for acid fast bacilli, fungus, and bacteria were negative. To our knowledge, there has been only one other report of bacillary angiomatosis presenting with pseudoepitheliomatous hyperplasia. We conclude that the differential diagnosis of entities associated with pseudoepitheliomatous hyperplasia should be expanded to include bacillary angiomatosis. PMID:16456322

Amsbaugh, Sean; Huiras, Erin; Wang, Nadia S; Wever, Aaron; Warren, Simon

2006-02-01

115

Angiolymphoid hyperplasia with eosinophilia: efficacy of isotretinoin?  

Microsoft Academic Search

BACKGROUND: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign but potentially disfiguring vascular lesion. It is usually characterized by dermal and subcutaneous nodules, primarily in the head and neck region. Spontaneous regression is common, but persistent or recurrent lesions may require treatment. Several treatments have been reported but surgery is the most efficient one. METHODS AND RESULTS: We report a

Fouad El Sayed; Rola Dhaybi; Alfred Ammoury; Myrna Chababi

2006-01-01

116

Hereditary Pituitary Hyperplasia with Infantile Gigantism  

PubMed Central

Context: We report hereditary pituitary hyperplasia. Objective: The objective of the study was to describe the results of the clinical and laboratory analysis of this rare instance of hereditary pituitary hyperplasia. Design: The study is a retrospective analysis of three cases from one family. Setting: The study was conducted at the National Institutes of Health, a tertiary referral center. Patients: A mother and both her sons had very early-onset gigantism associated with high levels of serum GH and prolactin. Interventions: The condition was treated by total hypophysectomy. Main Outcome Measure(s): We performed clinical, pathological, and molecular evaluations, including evaluation basal and provocative endocrine testing, neuroradiological assessment, and assessment of the pituitary tissue by microscopic evaluation, immunohistochemistry, and electron microscopy. Results: All three family members had very early onset of gigantism associated with abnormally high serum levels of GH and prolactin. Serum GHRH levels were not elevated in either of the boys. The clinical, radiographic, surgical, and histological findings indicated mammosomatotroph hyperplasia. The pituitary gland of both boys revealed diffuse mammosomatotroph hyperplasia of the entire pituitary gland without evidence of adenoma. Prolactin and GH were secreted by the same cells within the same secretory granules. Western blot and immunohistochemistry demonstrated expression of GHRH in clusters of cells distributed throughout the hyperplastic pituitary of both boys. Conclusions: This hereditary condition seems to be a result of embryonic pituitary maldevelopment with retention and expansion of the mammosomatotrophs. The findings suggest that it is caused by paracrine or autocrine pituitary GHRH secretion during pituitary development.

Glasker, Sven; Vortmeyer, Alexander O.; Lafferty, Antony R. A.; Hofman, Paul L.; Li, Jie; Weil, Robert J.; Zhuang, Zhengping

2011-01-01

117

Regenerative electronic biosensors using supramolecular approaches.  

PubMed

A supramolecular interface for Si nanowire FETs has been developed with the aim of creating regenerative electronic biosensors. The key to the approach is Si-NWs functionalized with ?-cyclodextrin (?-CD), to which receptor moieties can be attached with an orthogonal supramolecular linker. Here we demonstrate full recycling using the strongest biomolecular system known, streptavidin (SAv)-biotin. The bound SAv and the linkers can be selectively removed from the surface through competitive desorption with concentrated ?-CD, regenerating the sensor for repeated use. An added advantage of ?-CD is the possibility of stereoselective sensors, and we demonstrate here the ability to quantify the enantiomeric composition of chiral targets. PMID:23566420

Duan, Xuexin; Rajan, Nitin K; Routenberg, David A; Huskens, Jurriaan; Reed, Mark A

2013-04-08

118

Regenerative fuel cell systems for space station  

NASA Astrophysics Data System (ADS)

Regenerative fuel cell (RFC) systems are the leading energy storage candidates for Space Station. Key design features are the advanced state of technology readiness and high degree of system level design flexibility. Technology readiness was demonstrated through testing at the single cell, cell stack, mechanical ancillary component, subsystem, and breadboard levels. Design flexibility characteristics include independent sizing of power and energy storage portions of the system, integration of common reactants with other space station systems, and a wide range of various maintenance approaches. The design features led to selection of a RFC system as the sole electrochemical energy storage technology option for the space station advanced development program.

Hoberecht, M. A.; Sheibley, D. W.

1985-07-01

119

The essential materials paradigms for regenerative medicine  

NASA Astrophysics Data System (ADS)

Medical technology is changing rapidly. Several disease states can now be treated very effectively by implantable devices that restore mechanical and physical functionality, such as replacement of hip joints or restoration of heart rhythms by pacemakers. These techniques, however, are rather limited, and no biological functionality can be restored through the use of inert materials and devices. This paper explores the role of new types of biomaterials within the emerging area of regenerative medicine, where they are able to play a powerful role in persuading the human body to regenerate itself.

Williams, David

2011-04-01

120

Directly diode-pumped Colquiriite regenerative amplifiers  

NASA Astrophysics Data System (ADS)

The Colquiriite crystals are attractive materials for directly diode-pumped femtosecond oscillators and amplifiers. Cr:LiSAF, Cr:LiSGAF and Cr:LiCAF are for the first time directly compared for their use in regenerative amplifiers both experimentally and theoretically. A maximum pulse energy of 10 ?J was obtained at an absorbed pump power of 1.1 W. A review of the work is given including a Cr:LiSAF seed oscillator, outlining specific needs for seeding.

Isemann, A.; Weßels, P.; Fallnich, C.

2006-04-01

121

Multiple excitation regenerative amplifier inertial confinement system  

DOEpatents

The invention relates to apparatus and methods for producing high intensity laser radiation generation which is achieved through an optical amplifier-storage ring design. One or two synchronized, counterpropagating laser pulses are injected into a regenerative amplifier cavity and amplified by gain media which are pumped repetitively by electrical or optical means. The gain media excitation pulses are tailored to efficiently amplify the laser pulses during each transit. After the laser pulses have been amplified to the desired intensity level, they are either switched out of the cavity by some switch means, as for example an electro-optical device, for any well known laser end uses, or a target means may be injected into the regenerative amplifier cavity in such a way as to intercept simultaneously the counterpropagating laser pulses. One such well known end uses to which this invention is intended is for production of high density and temperature plasmas suitable for generating neutrons, ions and x-rays and for studying matter heated by high intensity laser radiation.

George, Victor E. (Livermore, CA); Haas, Roger A. (Pleasanton, CA); Krupke, William F. (Pleasanton, CA); Schlitt, Leland G. (Livermore, CA)

1980-01-01

122

Regenerative potential of the zebrafish corneal endothelium.  

PubMed

Corneal transparency, critical for clear vision, is maintained in part by the pump function of the corneal endothelial cells that are arrested in G(1) phase of the cell cycle in adult humans. Thus loss of endothelial cells leads to a decrease in endothelial cell density. A decrease below a critical threshold results in corneal edema and subsequent vision loss. Corneal edema due to endothelial dysfunction is a common indication for transplantation in developed countries. The zebrafish has emerged as a model for vertebrate regeneration due to its ease of genetic manipulation and remarkable regenerative capacity. The purpose of this study was to investigate the response and regenerative potential of the zebrafish corneal endothelium to pharmacological and mechanical injury. Similar to the human cornea, Na(+)/K(+) ATPase activity is necessary to maintain the pump function as intracameral injection of ouabain resulted in an increase in central corneal thickness. Surgical removal of the majority of the central corneal endothelium resulted in a similar increase in corneal thickness. Remarkably, by just one week post-injury the central corneal endothelium had largely re-formed. Immunofluorescence of phosphorylated histone H3 indicated that this recovery correlated with corneal endothelial cells re-entering the cell cycle. In conclusion, our results establish zebrafish as a useful model of corneal injury and repair that may offer insights into the mechanism of cell cycle arrest in human corneal endothelial cells. PMID:23108006

Heur, Martin; Jiao, Shuliang; Schindler, Simone; Crump, J Gage

2012-10-26

123

Integrated regenerative fuel cell experimental evaluation  

NASA Astrophysics Data System (ADS)

An experimental test program was conducted to investigate the performance characteristics of an integrated regenerative fuel cell (IRFC) concept. The IRFC consists of a separate fuel cell unit and electrolysis cell unit in the same structure, with internal storage of fuel cell product water and external storage of electrolysis cell produced hydrogen and oxygen. The fuel cell unit incorporates an enhanced Orbiter-type cell capable of improved performance at reduced weight. The electrolysis cell features a NiCo2O4 catalyst oxygen evolution eletrode with a porous Teflon cover to retard electrolyte loss. Six complete IRFC assemblies were assembled and performance tested at an operating temperature of 200 F (93.3 C) and reactant pressures up to 170 psia (117.2 n/cu cm) on IRFC No. 4. Anomalous pressure charge/discharge characteristics were encountered during performance evaluation. A reversible fuel cell incorporating a proprietary bi-functional oxygen electrode operated satisfactory at 200 F (93.3 C) at reactant pressures up to 50 psia (41.4 n/cu cm) as a regenerative fuel cell for one cycle, before developing an electrical short in the fuel cell mode. Electrolysis cell 300-hour endurance tests demonstrated the electrolyte retention capability of the electrode Teflon cover and the performance stability of the bi-functional oxygen electrode at high potential.

Martin, Ronald E.

1990-01-01

124

Erich Regener - a forgotten cosmic ray pioneer  

NASA Astrophysics Data System (ADS)

In the 1930s the German physicist Erich Regener (1881-1955), did important work on the measurement of the rate production of ionisation in the atmosphere and deep under-water. He discovered, along with one of his students, Georg Pfotzer, the altitude at which the production of ionisation in the atmosphere reaches a maximum, often and misleadingly called the Pfotzer maximum. He was one of the first to estimate the energy density of cosmic rays, an estimate used by Baade and Zwicky to postulate that supernovae might be the source of cosmic rays. Yet Regener's name is little known largely because he was forced to take early retirement by the National Socialists in 1937 as his wife had Jewish ancestors. In this paper we review his work on cosmic rays and the subsequent influence that he had on the subject through his son, his son-in-law, his grandson and his students. He was nominated for the Nobel Prize in Physics by Schroedinger in 1938. He died in 1955 at the age of 73.

Carlson, Per; Watson, Alan

2013-04-01

125

Unitized Regenerative Fuel Cell System Gas Dryer/Humidifier Analytical Model Development.  

National Technical Information Service (NTIS)

A lightweight Unitized Regenerative Fuel Cell (URFC) Energy Storage System concept is being developed at the NASA Glenn Research Center (GRC). This Unitized Regenerative Fuel Cell System (URFCS) is unique in that it uses Regenerative Gas Dryers/Humidifier...

K. A. Burke I. Jakupca

2004-01-01

126

Spectrum of carcinoembryonic antigen immunoreactivity from isolated ductal hyperplasias to atypical hyperplasias associated with infiltrating ductal breast cancer.  

PubMed Central

AIMS--To study the immunohistochemical expression of carcinoembryonic antigen (CEA) in ductal hyperplasia of the breast and to investigate its putative relation with atypia and co-existing infiltrating ductal carcinoma. METHODS--Paraffin wax embedded tissue from 37 cases of isolated ductal hyperplasia (five with atypia and 32 without atypia) and 25 cases of ductal hyperplasia associated infiltrating ductal carcinoma (IDC) (seven with atypia and 18 without atypia) was stained with a monoclonal anti-CEA antibody using a standard avidin biotin immunoperoxidase method. RESULTS--CEA immunoreactivity was observed in eight (12.8%) ductal hyperplasia cases. The percentage of CEA positivity in ductal hyperplasia cases with atypia (33.3%) was substantially higher than that observed in cases of ductal hyperplasia without atypia (8.0%). Six cases of ductal hyperplasia associated IDC reacted with CEA; in these six cases the neoplastic cells of the co-existing carcinoma were also CEA positive. The percentage of CEA immunoreactivity in ductal hyperplasia associated IDC was higher than that observed in isolated ductal hyperplasia (24.0 v 5.4%). The percentage of CEA immunoreactivity in atypical ductal hyperplasia associated IDC was similar to that observed in IDC alone (42.9 v 40.0%). CONCLUSIONS--The presence of CEA immunoreactivity has been confirmed in benign proliferative breast lesions. The prevalence of such immunoreactivity increases from 3.1% in isolated, nonatypical ductal hyperplasia to 42.9% in atypical ductal hyperplasia associated IDC. This finding and the similarity of the frequency of CEA positivity in atypical ductal hyperplasia associated IDC and in IDC alone suggests that there is a pathogenetic link between ductal hyperplasia and some types of breast cancer. Images

Schmitt, F C; Andrade, L

1995-01-01

127

Review on the Unitized Regenerative Fuel Cells Materials  

Microsoft Academic Search

Unitized regenerative fuel cell is a unique fuel cell can work in both electrolyser and fuel cell in one cell at different mode, its useful in some application in which the weight is an important issue. This article reviews current literatures with the objective of identifying the latest development in membrane and bipolar plate materials for the Unitized Regenerative Fuel

SALWAN S. DIHRAB; K. SOPIAN; A. ZAHARIM

128

Regenerative braking control method and optimal scheme for electric motorcycle  

Microsoft Academic Search

This paper describes an optimal regenerative braking control scheme for a permanent magnet brushless DC motor of an electric motorcycle to achieve dual goals of the electric brake and the maximal power harvest in two cases of the road, downhill and flat, without any additional changes on the hardware. Based on regenerative braking of brushless DC motor in half bridge

Wei Cui; Hang Zhang; Yan-li Ma; Yue-jin Zhang

2011-01-01

129

Research on control for regenerative braking of electric vehicle  

Microsoft Academic Search

The limitation of driving range is the key restriction for the development of EV (electric vehicle), and regenerative braking is an effective approach to extend the driving range of electric vehicle. To protect the battery from broken caused by large charging current during regenerative braking, the control strategy that makes the charging current as control object is proposed in this

Binggang Cao; Zhifeng Bai; Wei Zhang

2005-01-01

130

Regenerative Systems - Challenges and Opportunities for Modeling, Simulation, and Visualization  

Microsoft Academic Search

Regenerative systems are able to overcome significant perturba- tions, and maintain autonomously their functionality in dynamic and uncertain environments. More and more this ability of biologi- cal systems plays a role in designing technical systems, e.g., in sen- sor networks, as well. Important properties of regenerative systems are their dynamic structures and their operation on different spatial and temporal scales.

Adelinde M. Uhrmacher; Hans-Jörg Schulz; Heidrun Schumann; Lars Schwabe; Dirk Timmermann

2009-01-01

131

Johnson Space Center's Regenerative Life Support Systems Test Bed  

Microsoft Academic Search

The Regenerative Life Support Systems (RLSS) Test Bed at NASA's Johnson Space Center is an atmospherically closed, controlled environment facility for human testing of regenerative life support systems using higher plants in conjunction with physicochemical life support systems. The facility supports NASA's Advanced Life Support (ALS) Program. The facility is comprised of two large scale plant growth chambers, each with

D. J. Barta; D. L. Henninger

1996-01-01

132

Physiological Regeneration of Skin Appendages and Implications for Regenerative Medicine  

NSDL National Science Digital Library

The concept of regenerative medicine is relatively new, but animals are well known to remake their hair and feathers regularly by normal regenerative physiological processes. Here, we focus on 1) how extrafollicular environments can regulate hair and feather stem cell activities and 2) how different configurations of stem cells can shape organ forms in different body regions to fulfill changing physiological needs.

Cheng-Ming Chuong (University of Southern California, School of Medicine); Valerie Randall (University of Bradford); Randall Widelitz (University of Southern California, School of Medicine); Ping Wu (University of Southern California, School of Medicine); Ting-Xin Jiang (University of Southern California, School of Medicine)

2012-04-01

133

Composition of Exhaust from a Regenerative Turbine System  

Microsoft Academic Search

Particulate and hydrocarbon content of gases in a regenerative gas turbine was analyzed at several points. Particle samples were measured with a condensation nuclei counter, a light scattering single particle counter and an impactor. Hydrocarbon analyses were made using gas chromatography. The effects of operation with JP-4 and No. 2 fuel oil were noted. It was concluded that a regenerative

A. Lieberman

1968-01-01

134

A novel unitized regenerative proton exchange membrane fuel cell  

Microsoft Academic Search

A difficulty encountered in designing a unitized regenerative proton exchange membrane (PEM) fuel cell lies in the incompatibility of electrode structures and electrocatalyst materials optimized for either of the two functions (fuel cell or electrolyzer) with the needs of the other function. This difficulty is compounded in previous regenerative fuel cell designs by the fact that water, which is needed

O. J. Murphy; A. J. Cisar; A. Gonzalez-Martin; C. E. Salinas; S. F. Simpson

1995-01-01

135

Physiological regeneration of skin appendages and implications for regenerative medicine  

PubMed Central

The concept of regenerative medicine is relatively new, but animals are well known to remake their hair and feathers regularly by normal regenerative physiological processes. Here we focus on 1) how extra-follicular environments can regulate hair and feather stem cell activities and 2) how different configurations of stem cells can shape organ forms in different body regions to fulfil changing physiological needs.

Chuong, Cheng-Ming; Randall, Valerie A; Widelitz, Randall B.; Wu, Ping; Jiang, Ting-Xin

2013-01-01

136

Regenerative medicine. Opportunities and challenges: a brief overview.  

PubMed

Regenerative medicine is a new multi-disciplinary field aiming at the repair or replacement of disease body parts. The field is progressing at an unprecedented pace and although the opportunities are immense, many hurdles lie ahead. This brief review analyses the opportunities and challenges faced by regenerative medicine. PMID:20826477

Polak, Dame Julia

2010-09-08

137

Regenerative medicine. Opportunities and challenges: a brief overview  

PubMed Central

Regenerative medicine is a new multi-disciplinary field aiming at the repair or replacement of disease body parts. The field is progressing at an unprecedented pace and although the opportunities are immense, many hurdles lie ahead. This brief review analyses the opportunities and challenges faced by regenerative medicine.

Polak, Dame Julia

2010-01-01

138

Angiolymphoid hyperplasia with eosinophilia with follicular mucinosis.  

PubMed

Follicular mucinosis occurring along with angiolymphoid hyperplasia with eosinophils (ALHE) has been described in a 49-year-old male. The patient presented with pruritic hyperpigmented papules and nodules on the vertex and right parietal scalp. There was no any other complaint. Histopathological examination from one of the papule showed prominent blood vessels in the dermis lined by plump histiocytoid endothelial cells that were surrounded by a dense lymphoid infiltrate with numerous eosinophils; these findings are typical of angiolymphoid hyperplasia with eosinophilia. Features of follicular mucinosis were observed in the same section with 3 hyperplastic follicular infundibula containing pools of mucin in the infundibular epithelium. The concurrent occurrence of these 2 distinct histopathological patterns in the same biopsy specimen has been reported rarely. PMID:23716828

Gutte, Rameshwar; Doshi, Bhavana; Khopkar, Uday

2013-03-01

139

Focal cystic endometrial hyperplasia in a bitch.  

PubMed

Rapid abdominal enlargement and weight gain occurred in a four-year-old Rhodesian ridgeback bitch in late oestrus. The bitch was nulliparous. Severe cardiovascular dysfunction followed and an exploratory laparotomy was performed. A large, single, spheroid mass weighting 17 kg was located in the middle section of the left uterine horn. A diagnosis of sterile, focal, cystic endometrial hyperplasia was made from gross pathology, histopathology and bacteriology. The bitch made a complete recovery following an ovariohysterectomy. PMID:7723293

Cockcroft, P D

1995-02-01

140

New Treatments for Benign Prostatic Hyperplasia  

PubMed Central

Benign prostatic hyperplasia is the most common of all neoplasms. The most common treatment is prostatectomy, but other available therapies include androgen antagonists, ?-adrenergic blockers, anticholinergic agents, prostate dilation with a ballon, and urethral stents. Prostatectomy is likely to remain the standard of care for the foreseeable future because it is safe and much more effective than all other current and experimental forms of therapy.

Skepasts, Peter K.; Lee, Laurence M.

1991-01-01

141

Intravascular papillary endothelial hyperplasia in the hand  

Microsoft Academic Search

Papillary endothelial hyperplasia first described by Masson as vegetant intravascular hemangioendothelioma, is a reactive\\u000a endothelial proliferation that, in many respects, mimics an angiosarcoma. Such lesions are most commonly located within veins\\u000a of the head, neck and fingers, and must be included in differential diagnosis of vascular lesions. The clinicopathologic features\\u000a of an unusual hand case are reported because of the

A. Alfaro; D. Arenas; S. Sanz; I. Gonzalez

1999-01-01

142

Medical Treatment of Benign Prostatic Hyperplasia  

PubMed Central

Medical therapy for the treatment of benign prostatic hyperplasia (BPH) became an accepted standard of care in the 1990s following the reports of randomized, double-blind, placebo-controlled studies showing that finasteride, a 5-? reductase inhibitor, and terazosin, an ?-blocker, significantly improved lower urinary tract symptoms and increased peak urinary flow rates in men with BPH. This article reviews novel approaches to the pharmacological treatment of BPH.

Lepor, Herbert

2011-01-01

143

Laser treatment of benign prostatic hyperplasia  

Microsoft Academic Search

To evaluate the role of lasers that allow acute removal of obstructing tissue in the surgical treatment of benign prostatic\\u000a hyperplasia (BPH). A MEDLINE search over the last 6 years focused on randomized trials, large case series and review articles.\\u000a A total of more than 4,000 patients were analyzed with respect to the morbidity and outcome, and the advantages and disadvantages

Rainer M. Kuntz

2007-01-01

144

Restriction of intestinal stem cell expansion and the regenerative response by YAP.  

PubMed

A remarkable feature of regenerative processes is their ability to halt proliferation once an organ's structure has been restored. The Wnt signalling pathway is the major driving force for homeostatic self-renewal and regeneration in the mammalian intestine. However, the mechanisms that counterbalance Wnt-driven proliferation are poorly understood. Here we demonstrate in mice and humans that yes-associated protein 1 (YAP; also known as YAP1)--a protein known for its powerful growth-inducing and oncogenic properties--has an unexpected growth-suppressive function, restricting Wnt signals during intestinal regeneration. Transgenic expression of YAP reduces Wnt target gene expression and results in the rapid loss of intestinal crypts. In addition, loss of YAP results in Wnt hypersensitivity during regeneration, leading to hyperplasia, expansion of intestinal stem cells and niche cells, and formation of ectopic crypts and microadenomas. We find that cytoplasmic YAP restricts elevated Wnt signalling independently of the AXIN-APC-GSK-3? complex partly by limiting the activity of dishevelled (DVL). DVL signals in the nucleus of intestinal stem cells, and its forced expression leads to enhanced Wnt signalling in crypts. YAP dampens Wnt signals by restricting DVL nuclear translocation during regenerative growth. Finally, we provide evidence that YAP is silenced in a subset of highly aggressive and undifferentiated human colorectal carcinomas, and that its expression can restrict the growth of colorectal carcinoma xenografts. Collectively, our work describes a novel mechanistic paradigm for how proliferative signals are counterbalanced in regenerating tissues. Additionally, our findings have important implications for the targeting of YAP in human malignancies. PMID:23178811

Barry, Evan R; Morikawa, Teppei; Butler, Brian L; Shrestha, Kriti; de la Rosa, Rosemarie; Yan, Kelley S; Fuchs, Charles S; Magness, Scott T; Smits, Ron; Ogino, Shuji; Kuo, Calvin J; Camargo, Fernando D

2012-11-25

145

Regenerative medicine: implications for craniofacial surgery.  

PubMed

Craniofacial reconstruction of cases with complex anatomy challenges surgeons. The recently emerging field of tissue engineering and regenerative medicine has resulted in a variety of novel therapeutic concepts particularly in the craniofacial area. However, researchers still face significant problems when translating scientific concepts from the bench to the bedside. Reconstruction procedures depend on sustainability, aesthetic outcome, and functionality. Tissue engineering approaches yield powerful tools for long-term satisfying results enabling customized reconstruction and supporting natural healing processes. In conclusion, further advances of tissue-engineered reconstruction need multidisciplinary research to create complex tissue structures and make satisfactory outcomes clinically achievable for most patients. This review highlights clinical advances in the field and gives an overview about current scientific concepts. PMID:22421853

Schantz, Jan-Thorsten; Machens, Hans-Günther; Schilling, Arndt F; Teoh, Swee-Hin

2012-03-01

146

Understanding regenerative medicine: a commissioner's viewpoint.  

PubMed

Regenerative medicines (RMs) represent a relatively new mode of care. Commissioners of healthcare need a pragmatic method to identify RMs which are safe and that will, when delivered in the context of an appropriate care pathway, avoid premature death and reduce morbidity for patients. This article offers a way of distinguishing between those which are useful currently and those which are not, although they may be in the future. This information is set in the context of reflection on issues that experience has demonstrated to be relevant to funding RMs. This article is potentially useful to developers of RM products as well as to commissioners of care, as it demonstrates what information will be required for a key step towards the adoption of their product. PMID:23477402

Warren, Virginia

2013-03-01

147

Platelet gel: applications in dental regenerative surgery  

PubMed Central

Background Platelet growth factors obtained from platelet-rich plasma (PRP) are used in prosthetic and periodontal regenerative therapy in dentistry. Increased microvascular proliferation in the first 20 days is followed by enhanced osteoblast activity and immature osteoid formation within 3–6 weeks, improving the quality and quantity of newly formed bone tissue. The aim of this study was to evaluate, through three-dimensional X-ray monitoring, the amount of bone obtained after bone regeneration treatment with platelet gel from autologous PRP. Materials and methods Patients eligible for regenerative treatment of atrophic alveolar bone of the maxilla or mandible were studied. The patients’ autologous whole blood was collected at the Department of Immunology and Transfusion of San Matteo Hospital for the preparation of platelet gel. The bone at the treated sites was analysed prior to and 4 months after the treatment using the three-dimensional X-ray system Galileos. Results Over a period of 6 years, 133 patients were treated: 304 implants were inserted and there were five cases of failure. The regenerated bone area consisted of histologically immature osteoid tissue composed of thin trabeculae of vital bone and nuclei of osteocytes, associated with fibro-connective tissue. Discussion This co-operative trial between the Transfusion Centre, for standardised production and validation of the platelet gel, and the Dental Surgery room for its application showed that the technique appears effective and safe. Although difficulties were encountered because of the small sample size and the inability to carry out long-term histological controls, the use of small amounts of PRP (5–10%) combined with autologous bone (15–20%) and alloplastic material appears to reduce the need for bone grafting.

Forni, Franco; Marzagalli, Massimo; Tesei, Patrizia; Grassi, Alessandra

2013-01-01

148

Regenerative PN ranging experience with New Horizons during 2012  

NASA Astrophysics Data System (ADS)

The New Horizons mission to Pluto is the first deep space mission to include the capability of supporting regenerative PN ranging. During the current phase of the mission, sequential tone ranging supports the mission navigation requirements but regenerative ranging will expand the conditions (antenna selection, integration time, etc.) over which ranging will be successful during any extended mission following the Pluto fly-by, to objects in the Kuiper belt. Experience with regenerative ranging is being obtained now in preparation for its use in an extended mission. During most of 2012, New Horizons was in a hibernation state. Tracking was conducted between late April and early July. Six regenerative ranging passes were performed to bookend this interval; 2 at the beginning and 4 at the end. During that time, the distance between the spacecraft and Earth was in excess of 22 Astronautical Units (AU) and the Pr/No levels were below 15 dB-Hz. A seventh regenerative ranging pass was performed in May at a higher signal level in order to test the acquisition of the ranging code by the spacecraft during a variety of conditions. The consistency of the regenerative range measurements with the adjacent sequential tone ranging measurements has been demonstrated and serves as a check on the calibration of the regenerative ranging system conditions. The range measurement precision has been shown to follow the predictions that are based on the uplink and downlink signal power. The regenerative ranging system has been shown to acquire the uplink ranging code with and without a commanded reset and regardless of the noise bandwidth setting of the system. This paper will present the data that was obtained during 2012 and will describe the analysis results for the regenerative ranging experience during 2012.

Jensen, J. R.; Haskins, C. B.; DeBoy, C. C.

149

Biomarkers for Benign Prostatic Hyperplasia Progression  

PubMed Central

Despite the fact that almost all men will develop symptoms associated with benign prostatic hyperplasia within their lifetimes, no molecular markers for the disease or its likelihood to progress have been established. A marker of this type could be used to stratify patients into subpopulations as well as to identify individuals whose disease is most likely to progress. Several molecular biomarkers have high potential to fulfill these needs, although none is currently approved for the clinical setting. The future does look promising as research to find novel biologic biomarkers is progressing while existing markers are optimized and validated for clinical use.

Cannon, Grant W.; Getzenberg, Robert H.

2012-01-01

150

New Regenerative Cycle for Vapor Compression Refrigeration  

SciTech Connect

The main objective of this project is to confirm on a well-instrumented prototype the theoretically derived claims of higher efficiency and coefficient of performance for geothermal heat pumps based on a new regenerative thermodynamic cycle as comparing to existing technology. In order to demonstrate the improved performance of the prototype, it will be compared to published parameters of commercially available geothermal heat pumps manufactured by US and foreign companies. Other objectives are to optimize the design parameters and to determine the economic viability of the new technology. Background (as stated in the proposal): The proposed technology closely relates to EERE mission by improving energy efficiency, bringing clean, reliable and affordable heating and cooling to the residential and commercial buildings and reducing greenhouse gases emission. It can provide the same amount of heating and cooling with considerably less use of electrical energy and consequently has a potential of reducing our nations dependence on foreign oil. The theoretical basis for the proposed thermodynamic cycle was previously developed and was originally called a dynamic equilibrium method. This theory considers the dynamic equations of state of the working fluid and proposes the methods for modification of T-S trajectories of adiabatic transformation by changing dynamic properties of gas, such as flow rate, speed and acceleration. The substance of this proposal is a thermodynamic cycle characterized by the regenerative use of the potential energy of two-phase flow expansion, which in traditional systems is lost in expansion valves. The essential new features of the process are: (1) The application of two-step throttling of the working fluid and two-step compression of its vapor phase. (2) Use of a compressor as the initial step compression and a jet device as a second step, where throttling and compression are combined. (3) Controlled ratio of a working fluid at the first and second step of compression. In the proposed system, the compressor compresses the vapor only to 50-60% of the final pressure, while the additional compression is provided by a jet device using internal potential energy of the working fluid flow. Therefore, the amount of mechanical energy required by a compressor is significantly reduced, resulting in the increase of efficiency (either COP or EER). The novelty of the cycle is in the equipment and in the way the multi-staging is accomplished. The anticipated result will be a new refrigeration system that requires less energy to accomplish a cooling task. The application of this technology will be for more efficient designs of: (1) Industrial chillers, (2) Refrigeration plants, (3) Heat pumps, (4) Gas Liquefaction plants, (5) Cryogenic systems.

Mark J. Bergander

2005-08-29

151

Regenerative medicine techniques in cardiovascular disease: where is the horizon?  

PubMed

Regenerative medicine techniques to restore cardiac and vascular function are being increasingly investigated as management options for cardiovascular disease. The authors set out to identify emerging regenerative techniques in cardiovascular disease and investigate their stage of development. The relevant networks in the field in the UK were contacted and online sources for cell therapy, tissue engineering, and other regenerative techniques and products were searched for online. A total of 49 Phase II, II/III and III trials of regenerative products or techniques were identified: 13 Phase III, eight Phase II/III and 28 Phase II trials. Twelve of the Phase III trials are for myocardial ischemia and involve an intracoronary infusion or intramyocardial injection of autologous bone marrow-derived stem cells. Most of those in Phase III trials are, however, associated either with an unproven delivery technique or cellular approach. The authors conclude that translation into clinical practice and diffusion into health systems is some way off. PMID:23627828

Packer, Claire; Boddice, Beth; Simpson, Sue

2013-05-01

152

Armed Forces Institute of Regenerative Medicine: Clinical Trials.  

National Technical Information Service (NTIS)

AFIRM Mission: To provide cutting-edge medical capabilities to heal and reset our warriors who have catastrophic traumatic injuries and disabilities. Discover, develop, and translate regenerative medicine technologies having both near term and far-term tr...

T. Irgens

2011-01-01

153

Regenerative Medicine: Creating the Future for Military Medicine.  

National Technical Information Service (NTIS)

The Telemedicine & Advanced Technology Research Center (TATRC) has been funding and managing research in the area of regenerative medicine and tissue engineering since 2001. Starting with research in understanding the healing and regeneration of bone in m...

2009-01-01

154

Armed Forces Institute of Regenerative Medicine Annual Report 2011.  

National Technical Information Service (NTIS)

This report contains detailed technical information on all currently funded Armed Forces Institute of Regenerative Medicine research projects. The report is also available in a highlights version that provides summary information.

2012-01-01

155

3. INSIDE BATCH FURNACE BUILDING, VIEW LOOKING NORTH AT REGENERATIVE ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. INSIDE BATCH FURNACE BUILDING, VIEW LOOKING NORTH AT REGENERATIVE BATCH FURNACES ON LEFT AND 5 TON CAPACITY CHARGING MACHINE ON RIGHT. - U.S. Steel Duquesne Works, 22-Inch Bar Mill, Along Monongahela River, Duquesne, Allegheny County, PA

156

Novel Unitized Regenerative Proton Exchange Membrane Fuel Cell.  

National Technical Information Service (NTIS)

A difficulty encountered in designing a unitized regenerative proton exchange membrane (PEM) fuel cell lies in the incompatibility of electrode structures and electrocatalyst materials optimized for either of the two functions (fuel cell or electrolyzer) ...

O. J. Murphy A. J. Cisar A. Gonzalez-martin C. E. Salinas S. F. Simpson

1995-01-01

157

Regenerative Structure of Markov Chains Simulated via Common Random Numbers.  

National Technical Information Service (NTIS)

A standard strategy in simulation, for comparing two stochastic systems, is to use a common sequence of random numbers to drive both systems. Certain theoretical and methodological results require that the coupled system be regenerative. It is shown that ...

P. W. Glynn

1984-01-01

158

A 7.5GHz super regenerative detector  

Microsoft Academic Search

In this paper, simulated and measured results are presented for a microwave-integrated-circuit super regenerative detector operating at 7.5 GHz and brief comparisons made to a monolithic-microwave integrated-circuit super regenerative detector operating at 34 GHz. The sensitivity of the 7.5-GHz detector was measured at -83-dBm (AM, 1 kHz, 100 % mod) RF signal for 12 dB (signal + noise + distortion)\\/(noise

N. B. Buchanan; V. F. Fusco; J. A. C. Stewart

2002-01-01

159

Brushless ultra-efficient regenerative servomechanism  

SciTech Connect

A servomechanism regeneratively controls motion by a brushless coreless axial-field motor, exerting torque thru its permanent-magnet disk rotor, resulting from synchronized polyphase sinusoidal stator currents, controlled by a switching controller responsive to input commands and to Hall-effect transducer signals that vary sinusoidally with rotor angle and respectively correspond to stator phases. The controller operates with a dc power source and sink. Its signal processors derive from the transducer signals instantaneous magnitudes and polarities thereof and continuous lagless speed feedback. The instantaneous magnitudes are multiplied by a torque amplitude signal to provide respective synchronized amplitude control signals. Current transformers having primary windings in series with power switching transistors provide current feedback pulses with amplitude proportional to instaneous current in associated stator windings. Pulse control means initiate bi-phase pulses having restricted duty-cycle, and dictate pulse duration by comparing each current feedback pulse with the associated synchronized amplitude control signal. Switching logic responsive to the bi-phase pulses, to forward and reverse drive and brake commands, and to said polarities, accordingly controls selection and duty-cycle of said power switching transistors which, cooperative with free-wheeling diodes and inductors, effect controlled alternating stator currents.

Fradella, R. B.

1985-05-28

160

Regenerative medicine as applied to general surgery.  

PubMed

The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues, or organs to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues, and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate. PMID:22330032

Orlando, Giuseppe; Wood, Kathryn J; De Coppi, Paolo; Baptista, Pedro M; Binder, Kyle W; Bitar, Khalil N; Breuer, Christopher; Burnett, Luke; Christ, George; Farney, Alan; Figliuzzi, Marina; Holmes, James H; Koch, Kenneth; Macchiarini, Paolo; Mirmalek Sani, Sayed-Hadi; Opara, Emmanuel; Remuzzi, Andrea; Rogers, Jeffrey; Saul, Justin M; Seliktar, Dror; Shapira-Schweitzer, Keren; Smith, Tom; Solomon, Daniel; Van Dyke, Mark; Yoo, James J; Zhang, Yuanyuan; Atala, Anthony; Stratta, Robert J; Soker, Shay

2012-05-01

161

Introduction to stem cells and regenerative medicine.  

PubMed

Stem cells are a population of undifferentiated cells characterized by the ability to extensively proliferate (self-renewal), usually arise from a single cell (clonal), and differentiate into different types of cells and tissue (potent). There are several sources of stem cells with varying potencies. Pluripotent cells are embryonic stem cells derived from the inner cell mass of the embryo and induced pluripotent cells are formed following reprogramming of somatic cells. Pluripotent cells can differentiate into tissue from all 3 germ layers (endoderm, mesoderm, and ectoderm). Multipotent stem cells may differentiate into tissue derived from a single germ layer such as mesenchymal stem cells which form adipose tissue, bone, and cartilage. Tissue-resident stem cells are oligopotent since they can form terminally differentiated cells of a specific tissue. Stem cells can be used in cellular therapy to replace damaged cells or to regenerate organs. In addition, stem cells have expanded our understanding of development as well as the pathogenesis of disease. Disease-specific cell lines can also be propagated and used in drug development. Despite the significant advances in stem cell biology, issues such as ethical controversies with embryonic stem cells, tumor formation, and rejection limit their utility. However, many of these limitations are being bypassed and this could lead to major advances in the management of disease. This review is an introduction to the world of stem cells and discusses their definition, origin, and classification, as well as applications of these cells in regenerative medicine. PMID:23257690

Kolios, George; Moodley, Yuben

2012-12-13

162

Bioactive nanofibrous scaffolds for regenerative endodontics.  

PubMed

Here we report the synthesis, materials characterization, antimicrobial capacity, and cytocompatibility of novel antibiotic-containing scaffolds. Metronidazole (MET) or Ciprofloxacin/(CIP) was mixed with a polydioxanone (PDS)polymer solution at 5 and 25 wt% and processed into fibers. PDS fibers served as a control. Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), tensile testing, and high-performance liquid chromatography (HPLC) were used to assess fiber morphology, chemical structure, mechanical properties, and drug release, respectively. Antimicrobial properties were evaluated against those of Porphyromonas gingivalis/Pg and Enterococcus faecalis/Ef. Cytotoxicity was assessed in human dental pulp stem cells (hDPSCs). Statistics were performed, and significance was set at the 5% level. SEM imaging revealed a submicron fiber diameter. FTIR confirmed antibiotic incorporation. The tensile values of hydrated 25 wt% CIP scaffold were significantly lower than those of all other groups. Analysis of HPLC data confirmed gradual, sustained drug release from the scaffolds over 48 hrs. CIP-containing scaffolds significantly (p < .00001) inhibited biofilm growth of both bacteria. Conversely, MET-containing scaffolds inhibited only Pg growth. Agar diffusion confirmed the antimicrobial properties against specific bacteria for the antibiotic-containing scaffolds. Only the 25 wt% CIP-containing scaffolds were cytotoxic. Collectively, this study suggests that polymer-based antibiotic-containing electrospun scaffolds could function as a biologically safe antimicrobial drug delivery system for regenerative endodontics. PMID:24056225

Bottino, M C; Kamocki, K; Yassen, G H; Platt, J A; Vail, M M; Ehrlich, Y; Spolnik, K J; Gregory, R L

2013-09-20

163

Airway transplantation: a challenge for regenerative medicine  

PubMed Central

After more than 50 years of research, airway transplantation remains a major challenge in the fields of thoracic surgery and regenerative medicine. Five principal types of tracheobronchial substitutes, including synthetic prostheses, bioprostheses, allografts, autografts and bioengineered conduits have been evaluated experimentally in numerous studies. However, none of these works have provided a standardized technique for the replacement of the airways. More recently, few clinical attempts have offered encouraging results with ex vivo or stem cell–based engineered airways and tracheal allografts implanted after heterotopic revascularization. In 1997, we proposed a novel approach: the use of aortic grafts as a biological matrix for extensive airway reconstruction. In vivo regeneration of epithelium and cartilage were demonstrated in animal models. This led to the first human applications using cryopreserved aortic allografts that present key advantages because they are available in tissue banks and do not require immunosuppressive therapy. Favorable results obtained in pioneering cases have to be confirmed in larger series of patients with extensive tracheobronchial diseases.

2013-01-01

164

REGENERATIVE MEDICINE AS APPLIED TO GENERAL SURGERY  

PubMed Central

The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues or organs in order to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate.

Orlando, Giuseppe; Wood, Kathryn J; De Coppi, Paolo; Baptista, Pedro M; Binder, Kyle W; Bitar, Khalil N; Breuer, Christopher; Burnett, Luke; Christ, George; Farney, Alan; Figliuzzi, Marina; Holmes, James H; Koch, Kenneth; Macchiarini, Paolo; Sani, Sayed-Hadi Mirmalek; Opara, Emmanuel; Remuzzi, Andrea; Rogers, Jeffrey; Saul, Justin M; Seliktar, Dror; Shapira-Schweitzer, Keren; Smith, Tom; Solomon, Daniel; Van Dyke, Mark; Yoo, James J; Zhang, Yuanyuan; Atala, Anthony; Stratta, Robert J; Soker, Shay

2012-01-01

165

Regenerative treatment in spinal cord injury.  

PubMed

Spinal cord injury is a devastating, traumatic event, and experienced mainly among young people. Until the modern era, spinal cord injury was so rapidly fatal that no seriously injured persons would survive long enough for regeneration to occur. Treatment of spinal cord injury can be summarized as follows: prevent further cord injury, maintain blood flow, relieve spinal cord compression, and provide secure vertebral stabilization so as to allow mobilization and rehabilitation, none of which achieves functional recovery. Previous studies have focused on analyzing the pathogenesis of secondary injury that extends from the injury epicenter to the periphery, as well as the tissue damage and neural cell death associated with secondary injury. Now, there are hundreds of current experimental and clinical regenerative treatment studies. One of the most popular treatment method is cell transplantation in injured spinal cord. For this purpose bone marrow stromal cells, mononuclear stem cells, mesenchymal stem cells, embryonic stem cells, neural stem cells, and olfactory ensheathing cells can be used. As a result, cell transplantation has become a promising therapeutic option for spinal cord injury patients. In this paper we discuss the effectiveness of stem cell therapy in spinal cord injury. PMID:22849699

Ozdemir, Mevci; Attar, Ayhan; Kuzu, Isinsu

2012-09-01

166

New biomimetic directions in regenerative ophthalmology.  

PubMed

One of the most complete and permanent ways of treating many causes of visual impairment and blindness is to replace the entire affected tissue with pre-cultured ocular tissues supported and maintained on biomaterial frameworks. One direction towards enhancing ocular tissue regeneration on biomaterials, in the laboratory is by applying biomimicry. Specifically to engineer biomaterials with important functional elements of the native extracellular matrices, such as topography, that support and organise cells into coherent tissues. Further problems in regenerative ophthalmology can be potentially solved through application of biomimicry. They include, more efficient ways of moving and transplanting cultivated tissues into correct therapeutic locations inside the eye and scar-less, non-destructive healing of surgical incisions and wounds, to repair structural integrity of tissues at the ocular surface. Two examples are given to show this potential for redeveloping an ocular epithelium onto a nanostructured insect wing surface and producing an origami membrane modelled on deployable structures in nature. Efforts to harness natural innovation will eventually provide unique designs and structures that cannot for now be made synthetically, for regeneration of clinically acceptable ocular tissues. PMID:23184716

Green, David W; Watson, Gregory S; Watson, Jolanta; Abraham, Samuel J K

2012-02-15

167

Fascioliasis: Role of Proline in Bile Duct Hyperplasia  

Microsoft Academic Search

In animals with fascioliasis, extensive hyperplasia of the main bile duct occurs that often results in enlargement of the duct to more than 20 times the normal. We report that proline infused into the abdominal cavity of rats caused hyperplasia of the bile duct resembling that produced in the early stages of the disease. We suggest that Fasciola hepatica, which

Hadar Isseroff; Joseph T. Sawma; David Reino

1977-01-01

168

Florid pseudoepitheliomatous hyperplasia related to tattoo: a case report.  

PubMed

Pseudoepitheliomatous hyperplasia is a benign condition defined by an exuberant proliferation of the epithelium with downward progression into the dermis. It may occur in reaction to several conditions including chronic cutaneous wound. We describe an unusual case of a florid pseudoepitheliomatous hyperplasia mimicking a well-differentiated squamous cell carcinoma, restricted to the red part of a rose tattoo. PMID:22712583

de Roeck, Aurelie; Joujoux, Jean M; Fournier, Françoise; Dandurand, Michel; Meunier, Laurent; Stoebner, Pierre E

2012-06-19

169

The regenerative medicine coalition. Interview with Frank-Roman Lauter.  

PubMed

Frank-Roman Lauter, Secretary General of the recently launched Regenerative Medicine Coalition, explains how the coalition was formed and what they hope to achieve. Frank-Roman Lauter has served as Secretary General of the Regenerative Medicine Coalition since 2012, and as Head of Business Development at Berlin-Brandenburg Center for Regenerative Therapies since 2007. Frank-Roman Lauter's interest is the organization of academic infrastructures to promote efficient translation of research findings into new therapies. He co-organizes joined strategy development for regenerative medicine clusters from seven European countries (FP7-EU Project) and has initiated cooperation between the California Institute for Regenerative Medicine and the German Federal Ministry for Education & Research, resulting in a joined funding program. Recently, he cofounded the international consortium of Regenerative Medicine translational centers (RMC; www.the-rmc.org ). Trained as a molecular biologist at the Max-Planck Institute in Berlin-Dahlem and at Stanford, he has 16 years of experience as an entrepreneur and life science manager in Germany and the USA. PMID:23210813

Lauter, Frank-Roman

2012-11-01

170

Conditional Deletion of Pten Causes Bronchiolar Hyperplasia  

PubMed Central

Tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a lipid phosphatase that regulates multiple cellular processes including cell polarity, migration, proliferation, and carcinogenesis. In this work, we demonstrate that conditional deletion of Pten (Pten?/?) in the respiratory epithelial cells of the developing mouse lung caused epithelial cell proliferation and hyperplasia as early as 4 to 6 weeks of age. While bronchiolar cell differentiation was normal, as indicated by ?-tubulin and FOXJ1 expression in ciliated cells and by CCSP expression in nonciliated cells, cell proliferation (detected by expression of Ki-67, phospho-histone-H3, and cyclin D1) was increased and associated with activation of the AKT/mTOR survival pathway. Deletion of Pten caused papillary epithelial hyperplasia characterized by a hypercellular epithelium lining papillae with fibrovascular cores that protruded into the airway lumens. Cell polarity, as assessed by subcellular localization of cadherin, ?-catenin, and zonula occludens-1, was unaltered. PTEN is required for regulation of epithelial cell proliferation in the lung and for the maintenance of the normal simple columnar epithelium characteristics of bronchi and bronchioles.

Dave, Vrushank; Wert, Susan E.; Tanner, Tiffany; Thitoff, Angela R.; Loudy, Dave E.; Whitsett, Jeffrey A.

2008-01-01

171

Management of Congenital Adrenal Hyperplasia in Childhood  

PubMed Central

Purpose of review Congenital adrenal hyperplasia (CAH) can present management challenges to the pediatric clinician. Glucocorticoid replacement remains the cornerstone of treatment; however, there are new formulations and delivery mechanisms being studied. Clinicians continue to discuss the optimal treatment of patients from the prenatal stage, through infancy to adulthood. As well, the role of genetics in the clinical care of patients with CAH, and screening for complications, remain topics of discussion. This review will highlight advances made in the past year, as they pertain to the management of pediatric patients with CAH. Recent findings This article covers recent studies pertaining to optimal medication regimens, including prenatal dexamethasone treatment; medication delivery; monitoring of hormonal control; and the role of genotyping and genetics in the management of children with CAH. Summary Much remains to be learned about the optimal management of children with CAH, including fludrocortisone replacement in simple-virilizing patients, frequency of and specific monitoring strategies (e.g., electrolytes, bone age, etc.), catecholamine status, stress-dosing in non-classical adrenal hyperplasia, and early screening for complications or metabolic sequelae. Further randomized, prospective studies are needed to address these issues.

Kim, Mimi S.; Ryabets-Lienhard, Anna; Geffner, Mitchell E.

2013-01-01

172

Giant hepatic angiomyolipoma simulating focal nodular hyperplasia.  

PubMed

A case of hepatic angiomyolipoma occurring in a 41-year-old woman, the eighteenth case in literature, is reported herein. The radiographic imagings of the tumor simulated those of focal nodular hyperplasia; namely, the tumor was hyperechoic on ultrasound, hypodense on computed tomography, hypervascular on angiography, and exhibited an uptake of technetium (Tc)-99m phytate. The diagnosis was established after successful removal of the huge tumor from the right hepatic lobe. Histologically, the tumor was angiomyolipoma which was made up of three components, blood vessels, smooth muscle and fatty tissue. Furthermore, extramedullary hematopoiesis, which is usually seen in this tumor was confirmed. The differentiation of hepatic angiomyolipoma from FNH is also discussed. PMID:3404779

Miyahara, M; Kobayashi, M; Tada, I; Okada, K; Sato, K; Kim, Y I; Hiraoka, T; Yokoyama, S

1988-05-01

173

Benign prostatic hyperplasia: clinical manifestations and evaluation.  

PubMed

Benign prostatic hyperplasia (BPH) is a very common condition, related to aging and causing symptoms, called lower urinary tract symptoms. On account of its huge prevalence, it is important for clinicians who are involved in the management of patients with BPH to be aware of the very strict recommendations for BPH evaluation. In this article, we describe the different steps and procedures doctors should follow to evaluate these patients; symptoms and signs of BPH are reviewed, as well as the clinical evaluation steps and examinations available. The basic evaluation of the patients with BPH should include, according to the recommendations of the most relevant international guidelines, lower urinary tract symptoms evaluation with appropriate symptom scores, digital rectal examination, voiding charts, prostate-specific antigen and creatinine measurement, urinalysis, and imaging of the urinary tract. PMID:23244722

Santos Dias, José

2012-12-01

174

TOPICAL REVIEW: Cell and biomolecule delivery for regenerative medicine  

NASA Astrophysics Data System (ADS)

Regenerative medicine is an exciting field that aims to create regenerative alternatives to harvest tissues for transplantation. In this approach, the delivery of cells and biological molecules plays a central role. The scaffold (synthetic temporary extracellular matrix) delivers cells to the regenerative site and provides three-dimensional environments for the cells. To fulfil these functions, we design biodegradable polymer scaffolds with structural features on multiple size scales. To enhance positive cell-material interactions, we design nano-sized structural features in the scaffolds to mimic the natural extracellular matrix. We also integrate micro-sized pore networks to facilitate mass transport and neo tissue regeneration. We also design novel polymer devices and self-assembled nanospheres for biomolecule delivery to recapitulate key events in developmental and wound healing processes. Herein, we present recent work in biomedical polymer synthesis, novel processing techniques, surface engineering and biologic delivery. Examples of enhanced cellular/tissue function and regenerative outcomes of these approaches are discussed to demonstrate the excitement of the biomimetic scaffold design and biologic delivery in regenerative medicine.

Smith, Ian O.; Ma, Peter X.

2010-02-01

175

A novel unitized regenerative proton exchange membrane fuel cell  

NASA Astrophysics Data System (ADS)

A difficulty encountered in designing a unitized regenerative proton exchange membrane (PEM) fuel cell lies in the incompatibility of electrode structures and electrocatalyst materials optimized for either of the two functions (fuel cell or electrolyzer) with the needs of the other function. This difficulty is compounded in previous regenerative fuel cell designs by the fact that water, which is needed for proton conduction in the PEM during both modes of operation, is the reactant supplied to the anode in the electrolyzer mode of operation and the product formed at the cathode in the fuel cell mode. Drawbacks associated with existing regenerative fuel cells have been addressed in work performed at Lynntech. In a first innovation, electrodes function either as oxidation electrodes (hydrogen ionization or oxygen evolution) or as reduction electrodes (oxygen reduction or hydrogen evolution) in the fuel cell and electrolyzer modes, respectively. Control of liquid water within the regenerative fuel cell has been brought about by a second innovation. A novel PEM has been developed with internal channels that permit the direct access of water along the length of the membrane. Lateral diffusion of water along the polymer chains of the PEM provides the water needed at electrode/PEM interfaces. Fabrication of the novel unitized regenerative fuel cell and results obtained on testing it will be presented.

Murphy, O. J.; Cisar, A. J.; Gonzalez-Martin, A.; Salinas, C. E.; Simpson, S. F.

1995-04-01

176

Regenerative nanomedicine and the treatment of degenerative retinal diseases.  

PubMed

Regenerative medicine deals with the repair or the replacement of tissues and organs using advanced materials and methodologies. Regenerative nanomedicine uses nanoparticles containing gene transcription factors and other modulating molecules that allow reprogramming of cells in vivo as well as nanomaterials to induce selective differentiation of neural progenitor cells and to create neural-mechanical interfaces. In this article, we consider some applications of nanotechnology that may be useful for the treatment of degenerative retinal diseases, for example, use of nanoparticles for drug and gene therapy, use of nanomaterials for neural interfaces and extracellular matrix construction for cell-based therapy and neural prosthetics, and the use of bionanotechnology to re-engineer proteins and cell behavior for regenerative medicine. PMID:22170869

Zarbin, Marco A; Montemagno, Carlo; Leary, James F; Ritch, Robert

177

Hypoglycemia and Insular Hyperplasia: Review of 148 cases  

PubMed Central

On the bases of personal experience and the series of 148 cases from an international inquiry and a review of the literature, the relation between insular hyperplasia and hypoglycemia was examined. The fundamental points in this investigation included: age, diagnostic investigations, histological findings and postoperative results. The data on the patients with insular hyperplasia indicates that 83% were of adult age. Insular hyperplasia was the only abnormal factor determined to be present. Through treatment a high percentage of cases (71%) was cured. From a practical surgical point of view, differentiation between occult insulomas and insular hyperplasia is not critical. Consequently, good results can be achieved in botlh diseases by practicing a progressive blind resection guided by examination of the operated specimen and by intra-operative blood sugar levels. ImagesFigs. 1a. and 1b.Figs. 1a. and 1b.

Stefanini, Paride; Carboni, Manlio; Patrassi, Neri; Basoli, Antonio

1974-01-01

178

Thymic hyperplasia as a source of ectopic ACTH production.  

PubMed

A 26 year-old man with suspected Cushing's disease underwent transsphenoidal exploration of the pituitary without any evidence of microadenoma or hyperplasia. Progressive hypercortisolism necessitated bilateral adrenalectomy. Postoperatively, skin pigmentation gradually developed with a marked elevation of plasma ACTH levels, and CT scanning uncovered a thymic mass. Following removal of the thymic mass, skin pigmentation disappeared and plasma ACTH levels fell to normal. The excised mass was found to be a benign thymic hyperplasia without epithelial or carcinoid tumor cells. However, gel chromatography showed that the thymic tissue extract contained high ACTH content comparable to that of ectopic ACTH-producing tumors with a major component corresponding to ACTH(1-39). Northern blot analysis and in situ hybridization revealed the expression of proopiomelanocortin transcripts in lymphocytes of thymic hyperplasia. This report suggests that lymphocytes in thymic hyperplasia are the most likely site of deregulated ACTH expression causing ectopic ACTH syndrome. PMID:11075732

Ohta, K; Shichiri, M; Kameya, T; Matsubara, O; Imai, T; Marumo, F; Hirata, Y

2000-08-01

179

Coexistence of corticotroph adenoma and thyrotroph hyperplasia in a dog.  

PubMed

Pituitary thyrotroph hyperplasia results from prolonged primary hypothyroidism in humans, mice and rats. In dogs with Cushing's disease, many cases have low serum thyroid hormones concentrations due to euthyroid sick syndrome. A 6-year-old castrated male Beagle diagnosed with Cushing's disease had a high serum thyroid stimulating hormone (TSH) concentration that was treated by hypophysectomy. On histological examination, the resected pituitary gland contained both a corticotroph adenoma and thyrotroph hyperplasia. The TSH-positive cell ratio in this case was greater than that of healthy Beagles. In the present case, the pituitary thyrotroph hyperplasia was probably caused by primary hypothyroidism. In conclusion, this Beagle is the first histological confirmation of the coexistence of a corticotroph adenoma and thyrotroph hyperplasia. PMID:19194082

Teshima, Takahiro; Hara, Yasushi; Shigihara, Kae; Takekoshi, Susumu; Nezu, Yoshinori; Harada, Yasuji; Yogo, Takuya; Teramoto, Akira; Osamura, Robert Y; Tagawa, Masahiro

2009-01-01

180

Axon and muscle spindle hyperplasia in the myostatin null mouse  

PubMed Central

Germline deletion of the myostatin gene results in hyperplasia and hypertrophy of the tension-generating (extrafusal) fibres in skeletal muscle. As this gene is expressed predominantly in myogenic tissues it offers an excellent model with which to investigate the quantitative relationship between muscle and axonal development. Here we show that skeletal muscle hyperplasia in myostatin null mouse is accompanied by an increase in nerve fibres in major nerves of both the fore- and hindlimbs. We show that axons within these nerves undergo hypertrophy. Furthermore, we provide evidence that the age-related neural atrophic process is delayed in the absence of myostatin. Finally, we show that skeletal muscle hyperplasia in the myostatin null mouse is accompanied by an increase in the number of muscle spindles (also called stretch receptors or proprioceptors). However, our work demonstrates that the mechanisms regulating intrafusal fibre hyperplasia and hypertrophy differ from those that control the aetiology of extrafusal fibres.

Elashry, Mohamed I; Otto, Anthony; Matsakas, Antonios; El-Morsy, Salah E; Jones, Lisa; Anderson, Bethan; Patel, Ketan

2011-01-01

181

A high-power compact regenerative amplifier FEL  

SciTech Connect

The Regenerative Amplifier FEL (RAFEL) is a new FEL approach aimed at achieving the highest optical power from a compact rf-linac FEL. The key idea is to feed back a small fraction (< 10%) of the optical power into a high-gain ({approximately}10{sup 5} in single pass) wiggler to enable the FEL to reach saturation in a few passes. This paper summarizes the design of a high-power compact regenerative amplifier FEL and describes the first experimental demonstration of the RAFEL concept.

Nguyen, D.C.; Sheffield, R.L.; Fortgang, C.M.; Kinross-Wright, J.M.; Ebrahim, N.A.; Goldstein, J.C.

1997-08-01

182

Adipose-derived mesenchymal stem cells and regenerative medicine.  

PubMed

Adipose tissue-derived mesenchymal stem cells (ADSCs) are multipotent and can differentiate into various cell types, including osteocytes, adipocytes, neural cells, vascular endothelial cells, cardiomyocytes, pancreatic ?-cells, and hepatocytes. Compared with the extraction of other stem cells such as bone marrow-derived mesenchymal stem cells (BMSCs), that of ADSCs requires minimally invasive techniques. In the field of regenerative medicine, the use of autologous cells is preferable to embryonic stem cells or induced pluripotent stem cells. Therefore, ADSCs are a useful resource for drug screening and regenerative medicine. Here we present the methods and mechanisms underlying the induction of multilineage cells from ADSCs. PMID:23452121

Konno, Masamitsu; Hamabe, Atsushi; Hasegawa, Shinichiro; Ogawa, Hisataka; Fukusumi, Takahito; Nishikawa, Shimpei; Ohta, Katsuya; Kano, Yoshihiro; Ozaki, Miyuki; Noguchi, Yuko; Sakai, Daisuke; Kudoh, Toshihiro; Kawamoto, Koichi; Eguchi, Hidetoshi; Satoh, Taroh; Tanemura, Masahiro; Nagano, Hiroaki; Doki, Yuichiro; Mori, Masaki; Ishii, Hideshi

2013-03-03

183

Quantitative morphometry of squamous cell hyperplasia of the larynx.  

PubMed Central

The histopathological diagnosis of squamous cell hyperplasia of the larynx is very subjective. Since morphometry is highly reproducible, this method was applied to routine processed slides of 45 such lesions to assess objectively the epithelial characteristics. In each case measurements of nuclei of 50 cells in the basal, intermediate, and superficial cell layers were carried out. The data were analysed statistically. The findings suggest that quantitative morphometry may be helpful for the histopathological classification of squamous cell hyperplasia of the laryngeal mucosa. Images

Olde Kalter, P; Lubsen, H; Delemarre, J F; Alons, C L; Veldhuizen, R W; Meyer, C J; Snow, G B

1985-01-01

184

Reactive lymphoid hyperplasia one month after LASIK surgery  

Microsoft Academic Search

Background  To describe a case of reactive lymphoid hyperplasia following laser assisted in situ keratomileusis (LASIK).Methods  This observational case report describes a 31-year-old man who underwent LASIK and presented 1 month later with a fleshy, conjunctival (plical) tumour in the left eye. An excisional biopsy of the tumour was performed.Results  Histopathology of the excised tumour revealed reactive lymphoid hyperplasia involving the left conjunctiva.Discussion  Conjunctival

Shantan Reddy; Paul T. Finger; Emil W. Chynn; Codrin E. Iacob

2006-01-01

185

SPE (TM) Regenerative Hydrogen/Oxygen Fuel Cells for Extraterrestrial Surface and Microgravity Applications.  

National Technical Information Service (NTIS)

Viewgraphs on SPE regenerative hydrogen/oxygen fuel cells for extraterrestrial surface and microgravity applications are presented. Topics covered include: hydrogen-oxygen regenerative fuel cell energy storage system; electrochemical cell reactions; SPE c...

J. F. Mcelroy

1990-01-01

186

A study on regenerative braking for a parallel hybrid electric vehicle  

Microsoft Academic Search

In this paper, a regenerative braking algorithm is presented and performance of a hybrid electric vehicle (HEV) is investigated.\\u000a The regenerative braking algorithm calculates the available regenerative braking torque by considering the motor characteristics,\\u000a the battery SOC and the CVT speed ratio. When the regenerative braking and the friction braking are applied simultaneously,\\u000a the friction braking torque corresponding to the

Sungwook Jang; Hoon Yeo; Chulsoo Kim; Hyunsoo Kim

2001-01-01

187

Dutasteride/tamsulosin: in benign prostatic hyperplasia.  

PubMed

The 5?-reductase inhibitor dutasteride and the ?(1)-adrenergic receptor antagonist tamsulosin are available as a fixed-dose combination for use in men with symptomatic benign prostatic hyperplasia (BPH) and an enlarged prostate. Dutasteride 0.5?mg/day plus tamsulosin 0.4?mg/day improved lower urinary tract symptoms (LUTS) to a significantly greater extent than dutasteride or tamsulosin alone in men with BPH, moderate to severe LUTS and an increased risk of disease progression, according to the results of the randomized, double-blind, multinational CombAT trial. The mean change from baseline in the total International Prostate Symptom Score was significantly greater with dutasteride plus tamsulosin than with dutasteride or tamsulosin alone after 2 years (primary endpoint) and 4 years of therapy. After 4 years' therapy in the CombAT trial, the time to first acute urinary retention or BPH-related surgery (primary endpoint) significantly favoured men with symptomatic BPH who were receiving dutasteride plus tamsulosin versus those receiving tamsulosin alone, with no significant difference between recipients of dutasteride plus tamsulosin and recipients of dutasteride alone. In the CombAT trial, health-related quality of life and treatment satisfaction were improved to a significantly greater extent with dutasteride plus tamsulosin than with dutasteride or tamsulosin alone. Combination therapy with oral dutasteride plus tamsulosin was generally well tolerated in patients with symptomatic BPH in the CombAT trial. PMID:22550968

Keating, Gillian M

2012-05-01

188

Cinacalcet HCl prevents development of parathyroid gland hyperplasia and reverses established parathyroid gland hyperplasia in a rodent model of CKD  

PubMed Central

Background. Secondary hyperparathyroidism (sHPT) represents an adaptive response to progressively impaired control of calcium, phosphorus and vitamin D in chronic kidney disease (CKD). It is characterized by parathyroid hyperplasia and excessive synthesis and secretion of parathyroid hormone (PTH). Parathyroid hyperplasia in uremic rats can be prevented by calcium-sensing receptor (CaSR) activation with the calcimimetic cinacalcet (Sensipar®/Mimpara®); however, it is unknown, how long the effects of cinacalcet persist after withdrawal of treatment or if cinacalcet is efficacious in uremic rats with established sHPT. Methods. We sought to determine the effect of cinacalcet discontinuation in uremic rats and whether cinacalcet was capable of influencing parathyroid hyperplasia in animals with established sHPT. Results. Discontinuation of cinacalcet resulted in reversal of the beneficial effects on serum PTH and parathyroid hyperplasia. In rats with established sHPT, cinacalcet decreased serum PTH and mediated regression of parathyroid hyperplasia. The cinacalcet-mediated decrease in parathyroid gland size was accompanied by increased expression of the cyclin-dependent kinase inhibitor p21. Prevention of cellular proliferation with cinacalcet occurred despite increased serum phosphorus and decreased serum calcium. Conclusions. The animal data provided suggest established parathyroid hyperplasia can be reversed by modulating CaSR activity with cinacalcet and that continued treatment may be necessary to maintain reductions in PTH.

Miller, Gerald; Davis, James; Shatzen, Edward; Colloton, Matthew; Martin, David

2012-01-01

189

Optimization of the alignment sensitivity and energy stability of the NIF regenerative amplifier cavity/011.  

National Technical Information Service (NTIS)

The work to improve the energy stability of the regenerative amplifier ('regen') for the National Ignition Facility is described. This includes a fast feed-forward system, designed to regulate the output energy of the regen by monitoring how quickly a pul...

N. Hopps

1998-01-01

190

Application of Adaptive Sliding Mode Control for Regenerative Braking Torque Control  

Microsoft Academic Search

In air hybrid vehicles, there are two independent braking systems: frictional and regenerative. Since the regenerative braking torque is proportional to the parameters such as tank pressure and engine speed, a controller is needed for the control of the regenerative braking torque generated by internal combustion engine, based on the driver preference. In this work, a nonlinear control approach based

Amir Fazeli; Meysar Zeinali; Amir Khajepour

2012-01-01

191

SPE (tm) regenerative hydrogen\\/oxygen fuel cells for extraterrestrial surface and microgravity applications  

Microsoft Academic Search

Viewgraphs on SPE regenerative hydrogen\\/oxygen fuel cells for extraterrestrial surface and microgravity applications are presented. Topics covered include: hydrogen-oxygen regenerative fuel cell energy storage system; electrochemical cell reactions; SPE cell voltage stability; passive water removal SPE fuel cell; fuel cell performance; SPE water electrolyzers; hydrophobic oxygen phase separator; hydrophilic\\/electrochemical hydrogen phase separator; and unitized regenerative fuel cell.

J. F. McElroy

1990-01-01

192

SPE (tm) regenerative hydrogen/oxygen fuel cells for extraterrestrial surface and microgravity applications  

NASA Astrophysics Data System (ADS)

Viewgraphs on SPE regenerative hydrogen/oxygen fuel cells for extraterrestrial surface and microgravity applications are presented. Topics covered include: hydrogen-oxygen regenerative fuel cell energy storage system; electrochemical cell reactions; SPE cell voltage stability; passive water removal SPE fuel cell; fuel cell performance; SPE water electrolyzers; hydrophobic oxygen phase separator; hydrophilic/electrochemical hydrogen phase separator; and unitized regenerative fuel cell.

McElroy, J. F.

193

Induced pluripotent stem cells: developmental biology to regenerative medicine  

Microsoft Academic Search

Nuclear reprogramming of somatic cells with ectopic stemness factors to bioengineer pluripotent autologous stem cells signals a new era in regenerative medicine. The study of developmental biology has provided a roadmap for cardiac differentiation from embryonic tissue formation to adult heart muscle rejuvenation. Understanding the molecular mechanisms of stem-cell-derived cardiogenesis enables the reproducible generation, isolation, and monitoring of progenitors that

Almudena Martinez-Fernandez; Andre Terzic; Timothy J. Nelson

2010-01-01

194

Regenerative Electrical Igniter for a Liquid Propellant Gun.  

National Technical Information Service (NTIS)

A novel igniter for a regenerative liquid propellant gun (RLPG) is described, which utilizes only the liquid gun propellant (LGP). The liquid which is sealed in the igniter is ignited by an arc discharge causing a rise in pressure. At a predetermined pres...

A. Birk P. Reeves

1987-01-01

195

Review of thermally regenerative electrochemical systems, volume 2  

NASA Astrophysics Data System (ADS)

Thermally regenerative electrochemical systems(TRES) are reviewed and classified according to the type of energy input required to regenerate the electrochemical cell reactants; either thermal input alone or the coupling of thermal and electrolytic energy inputs. These two broad categories are further divided into seven types of TRES according to significant differences either the electrochemical cells or in the regenerators.

Chum, H. I.; Osteryoung, R. A.

1981-04-01

196

Permanent magnet synchronous generators for regenerative energy conversion - a survey  

Microsoft Academic Search

A survey on recently installed or developed permanent magnet (PM) synchronous generators for energy conversion in regenerative and alternative power supply systems is given. Its focus is for low speed machines on geared and gearless PM generator systems for wind power plants and small PM hydro generators in gearless coupling. For distributed co-generation of heat and electrical power by micro

Andreas Binder; Tobias Schneider

2005-01-01

197

Stem Cells, Regenerative Medicine, and Animal Models of Disease  

Microsoft Academic Search

The field of stem cell biology and regenerative medicine is rapidly moving toward translation to clinical practice, and in doing so has become even more dependent on animal donors and hosts for generating cellular reagents and assay- ing their potential therapeutic efficacy in models of human disease. Advances in cell culture technologies have revealed a remarkable plasticity of stem cells

Dennis A. Steindler

2007-01-01

198

Membrane electrode assemblies for unitised regenerative polymer electrolyte fuel cells  

Microsoft Academic Search

Membrane electrode assemblies for regenerative polymer electrolyte fuel cells were made by hot pressing and sputtering. The different MEAs are examined in fuel cell and water electrolysis mode at different pressure and temperature conditions. Polarisation curves and ac impedance spectra are used to investigate the influence of the changes in coating technique. The hydrogen gas permeation through the membrane is

U. Wittstadt; E. Wagner; T. Jungmann

2005-01-01

199

Sensitivity analysis of Markov regenerative stochastic Petri nets  

Microsoft Academic Search

Sensitivity analysis, i.e., the analysis of the effect of small variations in system parameters on the output measures, can be studied by computing the derivatives of the output measures with respect to the parameter. An algorithm for parametric sensitivity analysis of Markov regenerative stochastic Petri nets (MRSPN) is presented. MRSPNs are a true generalization of stochastic Petri nets, in that

Varsha Mainkar; H. Choi; K. Trivedi

1993-01-01

200

Development and prospects of organ replacement regenerative therapy.  

PubMed

: Current approaches for the development of regenerative therapies have been influenced by our understanding of embryonic development, stem cell biology, and tissue engineering technology. The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs to replace lost or damaged organs that result from disease, injury, or aging. Almost all organs including ectodermal organs, such as teeth, hair, salivary glands, and lacrimal glands, arise from organ germs induced by reciprocal epithelial-mesenchymal interactions in the developing embryo. A novel concept to generate a bioengineered organ is to recreate organogenesis and thereby develop fully functioning bioengineered organs from the resulting bioengineered organ germ generated via 3-dimensional cell manipulation using immature stem cells in vitro. We have previously developed a bioengineering method for forming a 3-dimensional organ germ in the early developmental stages, termed the "bioengineered organ germ method." Recently, we reported fully functioning bioengineered tooth replacements after transplantation of a bioengineered tooth germ or a mature tooth unit comprising the bioengineered tooth and periodontal tissues. This concept could be adopted to generate not only teeth but also bioengineered hair follicles, salivary glands, and lacrimal glands. These studies emphasize the potential for bioengineered organ replacement in future regenerative therapies. In this review, we will summarize the strategies and the recent progress of research and development for the establishment of organ replacement regenerative therapies. PMID:24104927

Hirayama, Masatoshi; Oshima, Masamitsu; Tsuji, Takashi

2013-11-01

201

Inherent regenerative losses of a ferroelectric Ericsson refrigeration cycle  

Microsoft Academic Search

The performance of a ferroelectric Ericsson refrigeration cycle is investigated on the basis of the statistic relation between the electrical polarization and the electric field strength of the ferroelectric materials. The inherent regenerative losses in the cycle are calculated. The coefficients of performance of the cycle are derived. Moreover, the performance of the Ericsson refrigeration cycle using other dielectric materials

Jizhou He; Jincan Chen; Jin T. Wang; Ben Hua

2003-01-01

202

[Enhancement of plantlet regenerative efficiency of watermelon in vitro].  

PubMed

The purpose of this study was to enhance shoot regenerative efficiency of watermelon by optimizing culture parameters. Cotyledons at 4-day seedlings were explanted and cultured on MS medium supplemented with different combinations of hormones. In "Yixuan" cultivar, the plantlet regenerative frequency and shoots produced by per explant was as low as 10% and 0.4 respectively at all combinations tested when distal parts of cotyledons were inoculated. Whereas, maximum regenerative frequency of 100 percentage and 10.3 shoots regenerated from per explant were observed on MS medium supplemented with 5 mg/L BA and 0.1 mg/L IAA using basal parts of cotyledons as explants. Likewise, in "Jingxinmuben" cultivar, the highest regenerative frequency of 100 percentage and 6.9 shoots regenerated from per explant were obtained when proximal parts of cotyledons were cultured on MS medium containing 2 mg/L BA and 0.5 mg/L IAA. In the present study, adventitious buds were initiated after only 4 d in culture and intact plantlets were obtained in 40 d culture. This will facilitate quicker gene transformation and polyploidy induction of watermelon in vitro. PMID:15789761

Zhang, Quan Mei; Zhang, Ming Fang

2004-12-01

203

Robotics and Automation in Regenerative Medicine for Musculoskeletal Applications  

Microsoft Academic Search

Aiming to structurally and functionally replace missing or damaged tissues, regenerative medicine can offer revolutionary therapeutical solution in addressing musculoskeletal conditions. Translation from basic research to affordable cost effective therapeutic procedures implies using advanced robotic and automatized technology for research, processing, quality control and future development. This paper overviews present status of robotics and automation applications for cell culturing, scaffold

Luminita Simion; Paul Botez; Florin Zugun-Eloae

2009-01-01

204

Smart biomaterials design for tissue engineering and regenerative medicine  

Microsoft Academic Search

As a prominent tool in regenerative medicine, tissue engineering (TE) has been an active field of scientific research for nearly three decades. Clinical application of TE technologies has been relatively restricted, however, owing in part to the limited number of biomaterials that are approved for human use. While many excellent biomaterials have been developed in recent years, their translation into

Mark E. Furth; Anthony Atala; Mark E. Van Dyke

2007-01-01

205

Regenerative medicine and human models of human disease  

Microsoft Academic Search

Recent advances in stem-cell technology are now allowing the mechanisms of human disease to be studied in human cells. A new era for regenerative medicine is arising from such disease models, extending beyond early cell-based therapies and towards evaluating genetic variation in humans and identifying the molecular pathways that lead to disease, as well as targets for therapy.

Kenneth R. Chien

2008-01-01

206

Cell delivery in regenerative medicine: The cell sheet engineering approach  

Microsoft Academic Search

Recently, cell-based therapies have developed as a foundation for regenerative medicine. General approaches for cell delivery have thus far involved the use of direct injection of single cell suspensions into the target tissues. Additionally, tissue engineering with the general paradigm of seeding cells into biodegradable scaffolds has also evolved as a method for the reconstruction of various tissues and organs.

Joseph Yang; Masayuki Yamato; Kohji Nishida; Takeshi Ohki; Masato Kanzaki; Hidekazu Sekine; Tatsuya Shimizu; Teruo Okano

2006-01-01

207

Mesenchymal stem cells for tissue engineering and regenerative medicine  

Microsoft Academic Search

Mesenchymal stem cells (MSCs) exist in bone marrow and other musculoskeletal tissues. These cells contribute to the homeostasis of musculoskeletal tissue as well as support for the growth and differentiation of primitive hemopoietic cells. Recent advancements in tissue engineering and regenerative medicine have highlighted MSCs as a potential source of cells which would differentiate to a variety of tissue tailored

Suk-Kee Tae; Seok-Hyn Lee; Jae-Sik Park; Gun-Il Im

2006-01-01

208

Adipose-Derived Stem Cells for Regenerative Medicine  

Microsoft Academic Search

Abstract—The emerging field of regenerative medicine will require a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue represents an abundant and accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in

Gary Lopaschuk; Jeffrey M. Gimble; Adam J. Katz; Bruce A. Bunnell

2010-01-01

209

Feasibility study of a simple unitized regenerative fuel cell  

Microsoft Academic Search

Conventional fuel cells use hydrogen and oxygen as the fuel and oxidant, respectively. Hydrogen and oxygen can be produced through electrolysis of water in an electrochemical cell. A simple unitized regenerative fuel cell (URFC), by combining an electrolyzer and a fuel cell, is constructed to check the feasibility of such a device. In the first cycle, hydrogen and oxygen gases

A. Verma; S. Basu

2004-01-01

210

Optimization of bifunctional electrocatalyst for PEM unitized regenerative fuel cell  

Microsoft Academic Search

To find the best operating conditions and oxygen electrode catalyst of the PEM unitized regenerative fuel cell (URFC) system, we examined the effect of reaction conditions and the performance of several bifunctional electrocatalysts for oxygen electrode in a single cell PEM URFC system. When Pt black was employed for both electrodes, the URFC performance improved with increasing cell temperature up

Sung-Dae Yim; Won-Yong Lee; Young-Gi Yoon; Young-Jun Sohn; Gu-Gon Park; Tae-Hyun Yang; Chang-Soo Kim

2004-01-01

211

Lightweight pressure vessels and unitized regenerative fuel cells  

Microsoft Academic Search

Energy storage systems have been designed using lightweight pressure vessels with unitized regenerative fuel cells (URFCs). The vessels provide a means of storing reactant gases required for URFCs; they use lightweight bladder liners that act as inflatable mandrels for composite overwrap and provide a permeation barrier. URFC systems have been designed for zero emission vehicles (ZEVs); they are cost competitive

F. Mitlitsky; B. Myers; A. H. Weisberg

1996-01-01

212

Vehicular hydrogen storage using lightweight tanks (regenerative fuel cell systems)  

Microsoft Academic Search

Energy storage systems with extremely high specific energy (>400 Wh\\/kg) have been designed that use lightweight tankage to contain the gases generated by reversible (unitized) regenerative fuel cells (URFCs). Lawrence Livermore National Laboratory (LLNL) will leverage work for aerospace applications supported by other sponsors (including BMDO, NASA, and USAF) to develop URFC systems for transportation and utility applications. Lightweight tankage

Fred Mitlitsky; B Myers; A H Weisberg

1999-01-01

213

Long life Regenerative Fuel Cell technology development plan  

Microsoft Academic Search

This paper summarizes a technology roadmap for completing advanced development of a Proton Exchange Membrane (PEM) Regenerative Fuel Cell (RFC) to meet long life (20,000 hrs at 50 percent duty cycle) mobile or portable power system applications on the surface of the moon and Mars. Development of two different sized RFC power system modules is included in this plan (3

Franklin D. Littman; Robert L. Cataldo; James F. McElroy; Jay K. Stedman

1992-01-01

214

A novel bifunctional electrocatalyst for unitized regenerative fuel cell  

Microsoft Academic Search

5wt.% of platinum (Pt) nanoparticles are highly dispersed on the surface of IrO2 by chemical reduction, and the catalyst is mixed with Pt black to be used as a novel bifunctional oxygen electrocatalyst for the unitized regenerative fuel cell (URFC). The novel cell has been evaluated in the hydrogen and oxygen fuel cell and water electrolysis modes, and compared to

Yining Zhang; Huamin Zhang; Yuanwei Ma; Jinbin Cheng; Hexiang Zhong; Shidong Song; Haipeng Ma

2010-01-01

215

Regenerative cooling for liquid propellant rocket thrust chambers  

Microsoft Academic Search

This work describes a calculation model for regeneratively cooled rocket thrust chambers. A computational program, based on a one-dimensional coolant pressure drop in the cooling channels. Radiation is included in the model. The channels have rectangular cross sections, the dimensions being determined during the calculations in order to maintain the wall temperature distributions at tolerable levels, with a minimum channel

Rafael Levy Rubin

1994-01-01

216

Trends in biomedical engineering: focus on Regenerative Medicine.  

PubMed

Regenerative medicine is a critical frontier in biomedical and clinical research. The major progresses in the last few years were driven by a strong clinical need which could benefit from regenerative medicine outcomes for the treatment of a large number of conditions including birth defects, degenerative and neoplastic diseases, and traumatic injuries. Regenerative medicine applies the principles of engineering and life sciences to enhance the comprehension of the fundamental biological mechanisms underlying the structure-function relationships in physiologic and pathologic tissues and to accomplish alternative strategies for developing in vitro biological substitutes which are able to restore, maintain, or improve tissue, and organ function. This paper reviews selected approaches currently being investigated at Politecnico di Milano in the field of regenerative medicine. Specific tissue-oriented topics are divided in three sections according to each developmental stage: in vitro study, pre-clinical study, and clinical application. In vitro studies investigate the basic phenomena related to gene delivery, stem cell behavior, tissue regeneration, and to explore dynamic culture potentiality in different applications: cardiac and skeletal muscle, cartilage, hematopoietic system, peripheral nerve, and gene delivery. Specific fields of regenerative medicine, i.e., bone, blood vessels, and ligaments engineering have already reached the preclinical stage providing promising insights for further research towards clinical applications. The translation of the results obtained during in vitro and preclinical steps into clinical organ replacement is a very challenging issue, which can offer a valid alternative to fight morbidity, organ shortage, and ethical-social problems associated with allotransplantation as shown in the clinical case reported in this review. PMID:22065385

Asnaghi, M Adelaide; Candiani, Gabriele; Farè, Silvia; Fiore, Gianfranco B; Petrini, Paola; Raimondi, Manuela T; Soncini, Monica; Mantero, Sara

217

Laparoscopic Adrenalectomy for Nonfamilial Adrenal Medullary Hyperplasia  

PubMed Central

Background and Objectives: Sporadic adrenomedullary hyperplasia (AMH) is characterized by a medical history of hypertension, excessive catecholamine excretion, and histomorphometric evidence of increased adrenomedullary tissue relative to the cortex in the absence of multiple endocrine neoplasia. The aim of this study was to perform a retrospective analysis of patients after laparoscopic adrenalectomy for AMH, an early form of sporadic adrenal medulla–related endocrine hypertension, as well as to update our understanding of the clinical features and management of this clinicomorphologic entity. Methods: We performed a retrospective review of the medical records of patients operated on between 2007 and 2011 at Reina Sofia University General Hospital, Murcia, Spain, with a diagnosis of AMH. Patient characteristics, diagnostic studies, surgical procedures, and histologic findings were analyzed. Results: Seven hypertensive patients with intermittent adrenergic crises were found to have AMH (3 men and 4 women; mean age, 44 years). Catecholamine levels were increased. Radiologic studies included 1 or more of the following: magnetic resonance imaging, computed tomography, positron emission tomography imaging with fluorodeoxyglucose, dihydroxyphenylalanine–positron emission tomography–computed tomography, Octreoscan (Mallinckrodt Pharmaceuticals, St. Louis, MO, USA) and 123I-metaiodobenzylguanidine scintigraphy. Laparoscopic adrenalectomy was performed in all cases. One patient underwent bilateral adrenalectomy because of persistent symptomatology after unilateral adrenalectomy. Surgery was associated with normalization of catecholamine hypersecretion and complete disappearance of symptoms, as well as the reduction or abstention of antihypertensive therapy. Conclusions: Sporadic AMH is a clinicomorphologic entity that may mimic pheochromocytoma clinically. Recent advances in diagnostic and surgical methods have changed the management and outcome of this unusual disease. Laparoscopic adrenalectomy may be recommended as the gold standard in the treatment of this entity. Definitive diagnosis is provided by histologic study.

Candel Arenas, Maria Fe; Gonzalez Valverde, Francisco Miguel; Terol Garaulet, Emilio; Maestre Maderuelo, Maria; Meoro Aviles, Amparo; Pastor Quirante, Francisco; Albarracin Marin Blazquez, Antonio

2013-01-01

218

Current laser treatments for benign prostatic hyperplasia.  

PubMed

The latest technical improvements in the surgical armamentarium are remarkable. In particular, advancements in the urologic field are so exceptional that we could observe the flare-up of robot-assisted laparoscopic radical prostatectomy for prostate cancer and laser prostatectomy for benign prostatic hyperplasia (BPH). Photoselective vaporization of the prostate (PVP) and holmium laser prostatectomy are the most generalized options for laser surgery of BPH, and both modalities have shown good postoperative results. In comparison to transurethral prostatectomy (TURP), they showed similar efficacy and a much lower complication rate in randomized prospective clinical trials. Even in cases of large prostates, laser prostatectomy showed comparable efficacy and safety profiles compared to open prostatectomy. From a technical point of view, PVP is considered to be an easier technique for the urologist to master. Furthermore, patients can be safely followed up in an outpatient clinic. Holmium laser enucleation of the prostate (HoLEP) mimics open prostatectomy because the adenomatous tissue is peeled off the surgical capsule in both procedures. Therefore, HoLEP shows notable volume reduction of the prostate similar to open prostatectomy with fewer blood transfusions, shorter hospital stay, and cost reduction regardless of prostate size. Outcomes of laser prostatectomy for BPH are encouraging but sometimes are unbalanced because safety and feasibility studies were reported mainly for PVP, whereas long-term data are mostly available for HoLEP. We need longer-term randomized clinical data to identify the reoperation rate of PVP and to determine which procedure is the ideal alternative to TURP and open prostatectomy for each patient. PMID:21165192

Son, Hwancheol; Song, Sang Hoon; Paick, Jae-Seung

2010-11-17

219

?-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation.  

PubMed

The Wnt/?-catenin signaling is essential for various organogenesis and is often implicated during tumorigenesis. Dysregulated ?-catenin signaling is associated with the formation of endometrial adenocarcinomas (EACs), which is considered as the common form of endometrial cancer in women. In the current study, we investigate the downstream target of Wnt/?-catenin signaling in the uterine epithelia and the mechanism leading to the formation of endometrial hyperplasia. We report that conditional ablation and activation of ?-catenin in the uterine epithelia lead to aberrant epithelial structures and endometrial hyperplasia formation, respectively. We demonstrate that ?-catenin regulates Foxa2 with its candidate upstream region for the uterine epithelia. Furthermore, knockdown of Foxa2 leads to defects in cell cycle regulation, suggesting a possible function of Foxa2 in the control of cell proliferation. We also observe that ?-catenin and Foxa2 expression levels are augmented in the human specimens of complex atypical endometrial hyperplasia, which is considered to have a greater risk of progression to EACs. Thus, our study indicates that ?-catenin regulates Foxa2 expression, and this interaction is possibly essential to control cell cycle progression during endometrial hyperplasia formation. Altogether, the augmented expression levels of ?-catenin and Foxa2 are essential features during the formation of endometrial hyperplasia. PMID:22945641

Villacorte, M; Suzuki, K; Hirasawa, A; Ohkawa, Y; Suyama, M; Maruyama, T; Aoki, D; Ogino, Y; Miyagawa, S; Terabayashi, T; Tomooka, Y; Nakagata, N; Yamada, G

2012-09-03

220

Pathophysiology and management of endometrial hyperplasia and carcinoma.  

PubMed Central

Endometrial cancer is currently the commonest pelvic malignancy affecting American women, most of whom share the same pathophysiologic basis, that is, unopposed estrogenic stimulation. The initial result of hyperestrogenism is the development of endometrial hyperplasia, which is reversible in most cases by appropriate hormonal therapy. Persistent stimulation eventually leads to atypical hyperplasia with nuclear atypia and invasive carcinoma. Because there is no cost-effective screening method for the detection of endometrial hyperplasia and carcinoma, it is essential to survey the high-risk population with appropriate diagnostic techniques. After diagnosis, therapy should be individualized based on pathologic findings (cell type and histologic grade) and extent of disease (International Federation of Gynaecologists and Obstetricians stage, depth of myometrial invasion, and pelvic and para-aortic lymph node status). Recent studies suggest that sex hormone receptors and nuclear DNA ploidy patterns provide useful prognostic information independent of histologic grade. Images

Fu, Y. S.; Gambone, J. C.; Berek, J. S.

1990-01-01

221

[Intimal hyperplasia within a vascular anastomosis].  

PubMed

Intimal hyperplasia (IH) appears to rank high amongst plausible causes of reconstructed arteries restenosis. It always occurs in the area of a surgical intervention on a vessel in response to a mechanical lesion. IH is the cause of thrombosis in 15 to 50% of cases following vascular reconstruction during the first year after the operation (with the exception of early thromboses, which are probably caused by an improperly performed interventional technique). Of a wide variety of clinical situations leading to development of IH in the vascular wall, for the purposes of the present review, we singled out the problem concerning the onset and development of this tissue reaction in intervascular anastomoses, which is currently one of the most important issues. Analysing the publications on the problem concerned showed that amongst significantfactors influencing the development of IH in the anastomosis, the investigators single out different parameters of the anastomoses, configuration (either an end-to-end or an end-to-side anastomosis, the use of special inserts and patches within the latter), as well as the use of autologous or synthetic conduits, blanket suture or interrupted suture, peculiarities of local haemodynamics (linear blood flow rate, distribution of parietal fraction forces, zones of stagnation and flow separation), etc. To a certain degree, the published data are rather controversial. There remain many problems, which are either unaddressed as yet, or insufficiently studied, if at all. For instance, while establishing an anastomosis between a bypass graft and an artery, surgeons often resort to endarterectomy. It is not known whether or not this technique would influence the IH pattern in the anastomosis concerned. Neither is it clear whether the high velocity flow exerts a direct damaging action upon the endothelium, whether it promotes the development of IH in the area of the lesion, and if affirmative, then what the mechanisms of this effect really are. Not studied is the role of various types of synthetic fibres and synthetic grafts (except PTFE), various kinds of suture material in the development of IH in the zone of a vascular anastomosis concerned. This of course is far from being a complete list of the challenges requiring further investigation. PMID:19791568

Kur'ianov, P S; Razuvaev, A S; Vavilov, V N

2008-01-01

222

Regenerative polymeric bus architecture for board-level optical interconnects.  

PubMed

A scalable multi-channel optical regenerative bus architecture based on the use of polymer waveguides is presented for the first time. The architecture offers high-speed interconnection between electrical cards allowing regenerative bus extension with multiple segments and therefore connection of an arbitrary number of cards onto the bus. In a proof-of-principle demonstration, a 4-channel 3-card polymeric bus module is designed and fabricated on standard FR4 substrates. Low insertion losses (? -15 dB) and low crosstalk values (< -30 dB) are achieved for the fabricated samples while better than ± 6 µm -1 dB alignment tolerances are obtained. 10 Gb/s data communication with a bit-error-rate (BER) lower than 10(-12) is demonstrated for the first time between card interfaces on two different bus modules using a prototype 3R regenerator. PMID:22714148

Bamiedakis, N; Hashim, A; Penty, R V; White, I H

2012-05-21

223

Regenerative medicine for the kidney: stem cell prospects & challenges  

PubMed Central

The kidney has key roles in maintaining human health. There is an escalating medical crisis in nephrology as growing numbers of patients suffer from kidney diseases that culminate in organ failure. While dialysis and transplantation provide life-saving treatments, these therapies are rife with limitations and place significant burdens on patients and healthcare systems. It has become imperative to find alternative ways to treat existing kidney conditions and preemptive means to stave off renal dysfunction. The creation of innovative medical approaches that utilize stem cells has received growing research attention. In this review, we discuss the regenerative and maladaptive cellular responses that occur during acute and chronic kidney disease, the emerging evidence about renal stem cells, and some of the issues that lie ahead in bridging the gap between basic stem cell biology and regenerative medicine for the kidney.

2013-01-01

224

Regenerative cell therapy and pharmacotherapeutic intervention in heart failure  

PubMed Central

Regenerative medicine represents a promising perspective on therapeutic angiogenesis in patients with cardiovascular disease, including heart failure. However, previous or ongoing clinical trials show ambiguous outcomes with respect to the benefit of regenerative therapy by means of bone marrow stem cell infusion in myocardial infarction patients. Therefore, it is necessary to set up a rational therapeutic strategy in the treatment of congestive heart failure. Chemokines, cytokines and growth factors, as well as pharmaceutical agents, may have an impact on endothelial progenitor cell (EPC) physiology and thus can provide targets for pharmacological intervention. Indeed, EPCs and stem cell niches both in bone marrow and myocardial tissue can be treated as an integral target for recruitment of EPCs from the bone marrow to the cardiac ischaemic niche. In this article, we individually place the signalling factors in their specified context, and explain their roles in the various phases of neovascularisation (see Part 1). (Neth Heart J 2008;16:337-43.)

Qian, C.; Schoemaker, R.G.; van Gilst, W.H.; Yu, B.; Roks, A.J.M.

2008-01-01

225

Reprogramming and transdifferentiation shift the landscape of regenerative medicine.  

PubMed

Regenerative medicine is a new interdisciplinary field in biomedical science, which aims at the repair or replacement of the defective tissue or organ by congenital defects, age, injury, or disease. Various cell-related techniques such as stem cell-based biotherapy are a hot topic in the current press, and stem cell research can help us to expand our understanding of development as well as the pathogenesis of disease. In addition, new technology such as reprogramming or dedifferentiation and transdifferentiation open a new area for regenerative medicine. Here we review new approaches of these technologies used for cell-based therapy and discuss future directions and challenges in the field of regeneration. PMID:23930590

Guo, Jingjing; Wang, Hu; Hu, Xingchang

2013-08-09

226

Regenerative medicine strategies for treatment of neurogenic bladder  

PubMed Central

Neurogenic bladder is a general term encompassing various neurologic dysfunctions in the bladder and external urethral sphincter caused by damage or disease. Therapeutic management options fall into the categories of conservative, minimally invasive or surgical. The current standard for surgical management is bladder augmentation using intestinal segments. However, because intestinal tissue possesses different functional characteristics to bladder tissue, numerous complications can ensue. Regenerative medicine uses combinations of cells and/or biomaterials to encourage regeneration of healthy tissue and offers an alternative approach for the replacement of lost or deficient organs, including the bladder. Promising results using the principles of regenerative medicine have already been obtained in children with neurogenic bladder caused by myelomeningocele. Human clinical trials, governed by the US FDA, are ongoing in the USA in both children and adults to further evaluate the safety and efficacy of this technology for regenerating bladders. More studies are in progress and additional advances in this field can be anticipated.

Soler, Roberto; Fullhase, Claudius; Atala, Anthony

2009-01-01

227

The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine  

PubMed Central

Biomechanical factors profoundly influence the processes of tissue growth, development, maintenance, degeneration, and repair. Regenerative strategies to restore damaged or diseased tissues in vivo and create living tissue replacements in vitro have recently begun to harness advances in understanding of how cells and tissues sense and adapt to their mechanical environment. It is clear that biomechanical considerations will be fundamental to the successful development of clinical therapies based on principles of tissue engineering and regenerative medicine for a broad range of musculoskeletal, cardiovascular, craniofacial, skin, urinary, and neural tissues. Biomechanical stimuli may in fact hold the key to producing regenerated tissues with high strength and endurance. However, many challenges remain, particularly for tissues that function within complex and demanding mechanical environments in vivo. This paper reviews the present role and potential impact of experimental and computational biomechanics in engineering functional tissues using several illustrative examples of past successes and future grand challenges.

Butler, David L.; Goldstein, Steven A.; Guo, X. Edward; Kamm, Roger; Laurencin, Cato T.; McIntire, Larry V.; Mow, Van C.; Nerem, Robert M.; Sah, Robert L.; Soslowsky, Louis J.; Spilker, Robert L.; Tranquillo, Robert T.

2009-01-01

228

Papillary endothelial hyperplasia in a TEC coronary atherectomy specimen.  

PubMed Central

Angiography in a 37 year old female with a three week history of typical crescendo angina found an 80% stenosis of the proximal left anterior descending (LAD) artery. The patient underwent percutaneous transluminal coronary angioplasty involving TEC artherectomy of the LAD artery. The specimen removed by atherectomy was found to have the appearance of papillary endothelial hyperplasia. This is an unusual histological diagnosis that occurs in association with thrombus. It is rarely found within arterial vessels and has not been reported in a coronary artery. Papillary endothelial hyperplasia is now thought to be a form of organising thrombus, probably dependent on the production of basic fibroblast growth factor by the endothelium. Images

Crilley, J. G.; Ritchie, C.; de Belder, M. A.

1997-01-01

229

[Rupture of hepatic focal nodular hyperplasia. About two cases].  

PubMed

The diagnostics of focal nodular hyperplasia is reached through the use of imaging. When the diagnostic is certain, surgical abstention is the rule. Nevertheless, we were confronted with two cases of a rare complication; that of intraperitoneal rupture. In this situation, we suggest to first do an arteriography to control the bleeding, then to perform surgery when the patient has reached hemodynamic stability. Spontaneous rupture as a complication of benign nodular hyperplasia remains a rare event and only five cases were reported in litterature. PMID:16443188

Koch, N; Gintzburger, D; Seelentag, W; Denys, A; Gillet, M; Halkic, N

2005-10-17

230

Introduction: Regenerative Medicine at the Heart of the Culture Wars  

Microsoft Academic Search

\\u000a Regenerative medicine is rich with Promethean promises. The use of human embryonic stem cells in research is justified by\\u000a its advocates in terms of promises to cure a wide range of diseases and disabilities, from Alzheimer’s and Parkinsonism to\\u000a the results of heart attacks and spinal cord injuries. More broadly, there is the Promethean allure of being able to redesign

King-Tak IP

231

Regenerative frequency division with a GaAs FET  

Microsoft Academic Search

The circuit concept to be described accomplishes regenerative frequency division by employing a GaAs FET which is biased near pinchoff. The concept aims at efficient utilization of basic device characteristics, providing well-behaved divider performance and easy circuit designability. This is exemplified with the help of an experimental 16-to-8-GHz divider circuit whose output response is studied for single-tone CW, RF-pulsed, and

C. Rauscher

1984-01-01

232

Specific heat of regenerative material RNi2 system  

NASA Astrophysics Data System (ADS)

The RNi2 system, in which R is one of the heavy REEs, Dy or Er, is proposed as the regenerative material of Ericsson cycle magnetic phase transition refrigerator systems. RNi2 was prepared in solid solution and examined for temperature variation of specific heat up to 5 T. The system is found to have a large specific heat below 20 K, due to ferro-to-paramagnetic transition. The Curie temperature is noted to be controllable by changing the REE composition.

Yayama, H.; Tomokiyo, A.; Hashimoto, T.; Kuzuhara, T.; Li, R.

1987-09-01

233

The Ovonic Regenerative Fuel Cell, A Fundamentally New Approach  

NSDL National Science Digital Library

This report introduces the Ovonic Regenerative fuel cell, which is a technology that "utilizes Ovonic metal hydride materials in place of traditional noble metal catalysts in the hydrogen fuel electrode." The paper goes into detail about how these fuel cells work and includes graphical representations of the processes involved. This paper was presented at the Hydrogen and Fuel Cells 2004 Conference and Trade Show in Toronto, Canada. This document may be downloaded in PDF file format.

Ovshinsky, S. R.; Venkatesan, S.; Corrigan, D. A.

2012-08-24

234

Regenerative amplification in alexandrite of pulses from specialized oscillators  

SciTech Connect

The authors describe an alexandrite regenerative amplifier used to amplify the output of various specialized oscillators. Nanosecond pulses from a narrow frequency CW-pumped dye laser, picosecond pulses from a gain-switched diode laser, and femtosecond pulses from a synchronously pumped dye laser were amplified by six-ten orders of magnitude in a single stage while conserving the temporal and spectral profiles characteristic to the oscillators.

Bado, P.; Pessot, M.; Squier, J.; Mourou, G.A.; Harter, D.J.

1988-06-01

235

Alexandrite-pumped alexandrite regenerative amplifier for femtosecond pulse amplification  

Microsoft Academic Search

We demonstrate a regenerative amplifier incorporating alexandrite as the gain medium that is pumped by an alexandrite laser. Temperature-altered gain permitted the 728-nm alexandrite pump laser, operating at room temperature, to pump a 780â800-nm alexandrite laser that was maintained at elevated temperatures. 200-fs pulses from a Ti:sapphire oscillator were amplified to the millijoule level. This system also amplified femtosecond pulses

A. Hariharan; M. E. Fermann; M. L. Stock; D. J. Harter; Jeff Squier

1996-01-01

236

NASA Lewis evaluation of Regenerative Fuel Cell (RFC) systems  

Microsoft Academic Search

Evaluation of two regenerative fuel cell (RFC) systems was begun in-house, and under contracts and grants. The passive hydrogen-oxygen RFC offers the possibility of a high-energy density, long-life storage system for geosynchronous Earth orbit missions. The hydrogen-bromine RFC offers the combination of high efficiency and moderate energy density that could ideally suit low Earth orbit missions if successfully developed. Either

N. H. Hagedorn; O. D. Gonzalez-Sanabria; L. L. Kohout

1986-01-01

237

Regenerative fuel cell study for satellites in GEO orbit  

Microsoft Academic Search

Summarized are the results of a 12-month study to identify high performance regenerative hydrogen-oxygen fuel cell concepts for geosynchronous satellite application. Emphasis was placed on concepts with the potential for high energy density (W-hr\\/lb) and passive means for water and heat management to maximize system reliability. Both polymer membrane and alkaline electrolyte fuel cells were considered, with emphasis on the

Alexander Levy; Leslie L. Vandine; James K. Stedman

1987-01-01

238

Cryogenic Reactant Storage for Lunar Base Regenerative Fuel Cells  

Microsoft Academic Search

There are major advantages to be gained by integrating a cryogenic reactant storage system with a hydrogen-oxygen regenerative fuel cell (RFC) to provide on-site electrical power during the lunar night. Although applicable to any power system using hydrogen-oxygen RFC's for energy storage, cryogenic reactant storage offers a significant benefit whenever the sun\\/shade cycle and energy storage period approach hundreds of

L. L. Kohout

1989-01-01

239

A unitized approach to regenerative solid polymer electrolyte fuel cells  

Microsoft Academic Search

In this work on regenerative fuel cells, the initial part deals with water electrolysis using a cell design that closely resembled that of a solid polymer fuel cell. The electrolytes were Nafion® 117 and the Dow experimental membrane. The electrodes were Pt-on-C and Pt\\/Ir-on-C gas diffusion electrodes on the oxygen side and Pt-on-C on the hydrogen side. Fuel cells were

Hari P. Dhar

1993-01-01

240

Deconstructing Stem Cell Tumorigenicity: A Roadmap to Safe Regenerative Medicine  

PubMed Central

Many of the earliest stem cell studies were conducted on cells isolated from tumors rather than from embryos. Of particular interest was research on embryonic carcinoma cells (EC), a type of stem cell derived from teratocarcinoma. The EC research laid the foundation for the later discovery of and subsequent work on embryonic stem cells (ESC). Both ESC isolated from the mouse (mESC) and then later from humans (hESC) shared not only pluripotency with their EC cousins, but also robust tumorigenicity as each readily form teratoma. Surprisingly, decades after the discovery of mESC, the question of what drives ESC to form tumors remains largely an open one. This gap in the field is particularly serious as stem cell tumorigenicity represents the key obstacle to the safe use of stem cell-based regenerative medicine therapies. Although some adult stem cell therapies appear to be safe, they have only a very narrow range of uses in human disease. Our understanding of the tumorigenicity of human induced pluripotent stem cells (IPSC), perhaps the most promising modality for future patient-specific regenerative medicine therapies, is rudimentary. However, IPSC are predicted to possess tumorigenic potential equal to or greater than that of ESC. Here, the links between pluripotency and tumorigenicity are explored. New methods for more accurately testing the tumorigenic potential of IPSC and of other stem cells applicable to regenerative medicine are proposed. Finally, the most promising emerging approaches for overcoming the challenges of stem cell tumorigenicity are highlighted.

Knoepfler, Paul S

2009-01-01

241

Neurosteroids as regenerative agents in the brain: therapeutic implications.  

PubMed

Regenerative therapeutics hold the promise of self-renewal and repair. Ageing and age-associated neurodegenerative diseases are marked by a decline in self-renewal and repair, but a capacity for regeneration is retained. The challenge faced by researchers developing molecular therapeutics to promote self-renewal in the nervous system is to activate regenerative and repair pathways often in the context of progressive degeneration. Neurosteroids regulate both regeneration and repair systems in the brain, and among this class of molecules, allopregnanolone has been broadly investigated for its role to promote regeneration in both the central and peripheral nervous systems. In the brain, allopregnanolone induced generation and survival of new neurons in the hippocampus of both aged mice and mice with Alzheimer disease, accompanied by restoration of associative learning and memory function. In the brain of mice with Alzheimer disease, allopregnanolone increased liver X receptor and pregnane X receptor expression, reduced amyloid-? and microglial activation, and increased markers of myelin and white matter generation. Therapeutic windows for efficacy of allopregnanolone were evident in the brains of mice with both normal ageing and Alzheimer disease. Allopregnanolone dose and a regenerative treatment regimen of intermittent allopregnanolone exposure were determining factors regulating therapeutic efficacy. Allopregnanolone serves as proof of concept for therapeutics that target endogenous regeneration, windows of therapeutic opportunity for regeneration, and critical system biology factors that will determine the efficacy of regeneration. PMID:23438839

Brinton, Roberta D

2013-02-26

242

Muscle stem cells in developmental and regenerative myogenesis  

PubMed Central

Purpose of review Skeletal muscle development serves as a paradigm for cell lineage specification and cell differentiation. Adult skeletal muscle has high regenerative capacity, with satellite cells the primary source of this capability. This review describes recent findings on developmental and adult myogenesis with emphasis on emerging distinctions between various muscle groups and stages of myogenesis. Recent findings Muscle progenitors of the body are derived from multipotent cells of the dermomyotome and express the transcription factors Pax3 and Pax7. These cells self-renew or induce expression of muscle regulatory factors (MRFs) and differentiate. The roles of Pax3+, Pax7+ and specific MRF+ progenitor populations in trunk and limb myogenesis have been identified through cell ablation in the mouse. Various head muscles and associated satellite cells have differing developmental origins, and rely on distinct combinations of transcriptional regulators, than trunk and limb muscles. Several genetic and sorting protocols demonstrate that satellite cells are heterogeneous with some possessing stem cell properties; the relative roles of lineage and niche in these properties are being explored. While cellular mechanisms of developmental, post-natal and adult regenerative myogenesis are thought to be similar, recent studies reveal distinct genetic requirements for embryonic, fetal, post-natal and adult regenerative myogenesis. Summary Genetic determinants of formation or repair of various muscles during different stages myogenesis are unexpectedly diverse. Future studies should illuminate these differences, as well as mechanisms that underlie stem cell properties of satellite cells.

Kang, Jong-Sun; Krauss, Robert S.

2010-01-01

243

Marching towards regenerative cardiac therapy with human pluripotent stem cells.  

PubMed

Damage in cardiac tissues from ischemia or other pathological conditions leads to heart failure; and cell loss or dysfunction in pacemaker tissues due to congenital heart defects, aging, and acquired diseases can cause severe arrhythmias. The promise of successful therapies with stem cells to treat these conditions has remained elusive to the scientific community. However, recent advances in this field have opened new opportunities for regenerative cardiac therapy. Transplantation of cardiomyocytes derived from human pluripotent stem cells has the potential to alleviate heart disease. Since the initial derivation of human embryonic stem cells, significant progress has been made in the generation and characterization of enriched cardiomyocytes and the demonstration of the ability of these cardiomyocytes to survive, integrate, and function in animal models. The scope of therapeutic potential from pluripotent stem cell-derived cardiomyocytes has been further expanded with the invention of induced pluripotent stem cells, which can be induced to generate functional cardiomyocytes for regenerative cardiac therapy in a patient specific manner. The reprogramming technology has also inspired the recent discovery of direct conversion of fibroblasts into cardiomyocyte-like cells, which may allow endogenous cardiac repair. Regenerative cardiac therapy with human pluripotent stem cells is now moving closer to clinic testing. PMID:23819949

Maher, Kevin O; Xu, Chunhui

2013-06-01

244

Numerical and Experimental Design Study of a Regenerative Pump  

NASA Astrophysics Data System (ADS)

This paper presents the use of a commercial CFD code to simulate the flow-field within the regenerative pump and compare the CFD results with new experimental data. Regenerative pumps are the subject of increased interest in industry as these pumps are low cost, low specific speed, compact and able to deliver high heads with stable performance characteristics. The complex flow-field within the regenerative pump represents a considerable challenge to detailed mathematical modelling. This paper also presents a novel rapid manufacturing process used to consider the effect of impeller geometry changes on the pump efficiency. Ten modified impeller blade profiles, relative to a standard radial configuration, were evaluated. The CFD performance results demonstrate reasonable agreement with the experimental tests. The CFD results also demonstrate that it is possible to represent the helical flow field for the pump which has only been witnessed in experimental flow visualisation until now. The ability to use CFD modelling in conjunction with rapid manufacturing techniques has meant that more complex impeller geometry configurations can now be assessed with better understanding of the flow-field and resulting efficiency.

Quail, Francis J.; Stickland, Matthew; Scanlon, Thomas

2010-03-01

245

Powering MEMS portable devices—a review of non-regenerative and regenerative power supply systems with special emphasis on piezoelectric energy harvesting systems  

Microsoft Academic Search

Power consumption is forecast by the International Technology Roadmap of Semiconductors (ITRS) to pose long-term technical challenges for the semiconductor industry. The purpose of this paper is threefold: (1) to provide an overview of strategies for powering MEMS via non-regenerative and regenerative power supplies; (2) to review the fundamentals of piezoelectric energy harvesting, along with recent advancements, and (3) to

K A Cook-Chennault; N Thambi; A M Sastry

2008-01-01

246

Foveolar hyperplasia following partial gastrectomy results from expansion of surface mucous cell compartment  

Microsoft Academic Search

Antrectomy with gastroenterostomy reconstruction is often associated with the development of foveolar hyperplasia and oxyntic atrophy. While a role for bile reflux in the etiology of foveolar hyperplasia is well established, the identity of the mucous cell lineages responsible for this condition have not been well characterized. We have studied three patients who demonstrated foveolar hyperplasia in their gastric remnant

Gregory S. Ray; Mark W. Jackson; James R. Goldenring

1996-01-01

247

Inhibition of neointimal hyperplasia in vascular grafts by sustained perivascular delivery of paclitaxel  

Microsoft Academic Search

Inhibition of neointimal hyperplasia in vascular grafts by sustained perivascular delivery of paclitaxel.BackgroundNeointimal hyperplasia occurs commonly at the anastomoses of arteriovenous grafts for chronic hemodialysis, causing stenosis and occlusion. Antiproliferative drugs may be effective in inhibiting hyperplasia, but local drug delivery would be required to minimize systemic side effects. We examined the feasibility of local drug delivery to inhibit neointimal

TAKAHISA MASAKI; RAMESH RATHI; GAYLEN ZENTNER; John K. Leypoldt; Syed F. Mohammad; Gregory L. Burns; LI LI; SERGEY ZHUPLATOV; THANIT CHIRANANTHAVAT; SEUNG-JUNG KIM; STEVEN KERN; JOHN HOLMAN; SUNG WAN KIM; Alfred K. Cheung

2004-01-01

248

Prostatic hyperplasia: an unknown feature of acromegaly.  

PubMed

This study was designed to investigate whether GH and insulin-like growth factor I (IGF-I) excess could lead to the development of benign prostatic hyperplasia and/or prostatic carcinoma. Prostatic diameters and volume as well as the occurrence of prostatic diseases were studied by ultrasonography in 10 untreated acromegalic patients less than 40 yr of age and 10 age- and body mass index-matched healthy males. Serum GH, IGF-I, PRL, testosterone, dihydrotestosterone, prostate-specific antigen, and prostatic acid phosphatase levels were assessed. All patients had secondary hypogonadism, as diagnosed by low testosterone levels, and 4 of 10 patients had hyperprolactinemia. After 1 yr of treatment with octreotide (0.3-0.6 mg/day), ultrasound scan and hormone parameters were repeated. The 4 hyperprolactinemic acromegalics were treated with octreotide and cabergoline (1-2 mg/week) to suppress PRL levels. Symptoms due to prostatic, seminal vesicle, and/or urethral disorders or obstruction were experienced by neither acromegalics nor controls. Digital rectal examination revealed no occurrence of prostatic nodules or other abnormalities. Compared to healthy subjects, a remarkable increase in transversal prostatic diameter and volume was observed in acromegalics. In healthy subjects, prostate volume ranged from 15.1-21.8 mL, whereas in acromegalics it ranged from 21.8-41.8 mL. Similarly, an increased median lobe was observed. In fact, the transitional zone diameter was just detectable in 5 of 10 controls, whereas it was measurable in all acromegalics (18 +/- 1.2 vs. 2.8 +/- 0.3 mm; P < 0.001). The prevalence of periurethral calcifications was more than doubled in acromegalics (50%) compared to that in controls (20%). Treatment with octreotide for 1 yr produced normalization of circulating GH and IGF-I levels in 7 of 10 patients. In these 7 patients, ultrasound evaluation showed a significant reduction of the antero-posterior diameter (26.1 +/- 1 vs. 28.9 +/- 1.6 mm; P < 0.01), the transversal diameter (44.9 +/- 2 vs. 48 +/- 2 mm; P < 0.01), and the cranio-caudal diameter (36.5 +/- 1 vs. 41.3 +/- 1.5 mm; P < 0.001), whereas the transitional zone diameter was unchanged (16.4 +/- 1.5 vs. 17.4 +/- 1.7 mm). As a consequence, a significant decrease in prostate volume was recorded (22.1 +/- 1.1 vs. 29.8 +/- 2.5 mL; P < 0.001). Prostate volume increased in 2 of the 3 patients who did not achieve normalization of GH and IGF-I after octreotide treatment. Finally, after treatment, serum testosterone levels were significantly increased (from 1.5 +/- 0.3 to 3.5 +/- 0.3 microg/L), whereas dihydrotestosterone, dehydroepiandrosterone sulfate, delta4-androstenedione, 17beta-estradiol, prostate-specific antigen, and prostatic acid phosphatase were unchanged. Serum PRL levels were suppressed after cabergoline treatment in all 4 hyperprolactinemic patients throughout the study period. In conclusion, prostate enlargement occurs in young acromegalics with a higher than expected prevalence of micro- and macrocalcifications. This suggests that a careful prostate screening should be included in the work-up and follow-up of acromegalic males. PMID:9506725

Colao, A; Marzullo, P; Ferone, D; Spiezia, S; Cerbone, G; Marinò, V; Di Sarno, A; Merola, B; Lombardi, G

1998-03-01

249

Atypical adenomatous hyperplasia of the lung in autopsy cases  

Microsoft Academic Search

Background: Atypical adenomatous hyperplasia (AAH) is a possible precursor lesion of adenocarcinoma of the lung, but very few reports of AAH have focused on the autopsy lung. Methods: We intended to clarify the characteristics of AAH in the general population by using 207 autopsy cases, ranging in age from 0 to 90 years old. Results: A total of 179 eligible

Tomoyuki Yokose; Mikio Doi; Kozo Tanno; Kentaro Yamazaki; Atsushi Ochiai

2001-01-01

250

Congenital adrenal hyperplasia: update on prenatal diagnosis and treatment  

Microsoft Academic Search

The diagnostic term congenital adrenal hyperplasia (CAH) applies to a family of inherited disorders of steroidogenesis caused by an abnormality in one of the five enzymatic steps necessary in the conversion of cholesterol to cortisol. The enzyme defects are translated as autosomal recessive traits, with the enzyme deficient in more than 90% of CAH cases being 21-hydroxylase. In the classical

A. D Carlson; J. S Obeid; N Kanellopoulou; R. C Wilson; M. I New

1999-01-01

251

Enterochromaffin cell hyperplasia and megacolon: report of a case.  

PubMed Central

A case of megacolon is described in which there was an unusual and focal hyperplasia of enterochromaffin cells in the mucosa. These formed discrete spherical acini in the lamina propria. These acini were not neoplastic and their significance is discussed. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5

Lindop, G B

1983-01-01

252

Psychosexual Development of Women with Congenital Adrenal Hyperplasia  

Microsoft Academic Search

Women with congenital adrenal hyperplasia (CAH) (N= 31) and their unaffected sisters or female cousins (N= 15) participated in a study of psychosexual development. All participants were ?18 years of age (mean age, 25 years; range, 18–40). Comparisons were also made between the CAH women with the salt-wasting (SW) form of the disorder and those with simple virilization (SV). A

Kenneth J. Zucker; Susan J. Bradley; Gillian Oliver; Jennifer Blake; Susan Fleming; Jane Hood

1996-01-01

253

Hyperinsulinaemia as a Risk Factor for Developing Benign Prostatic Hyperplasia  

Microsoft Academic Search

Objective: To determine the validity coefficient of the total prostate gland volume as an expression of the transition zone (TZ) volume. To test the hypothesis of hyperinsulinaemia as a causal factor for the development of benign prostatic hyperplasia (BPH).Patients and Methods: Three hundred and seven consecutive patients with lower urinary tract symptoms were studied. A subgroup of 114 patients were

Jan Hammarsten; Benkt Högstedt

2001-01-01

254

Rapidly Growing Bilateral Pseudoangiomatous Stromal Hyperplasia of the Breast  

PubMed Central

A tumoral pseudoangiomatous stromal hyperplasia (PASH) that causes huge breast enlargement is very rare. Only two cases of huge tumoral PASHs have been reported in the English medical literature. We report here on a surgically confirmed case of bilateral huge tumoral PASH in a 47-year-old woman, and we present the imaging and histopathology findings. We also review the relevant medical literature.

Ryu, Eun Mi; Chang, Eun Deok

2010-01-01

255

Human benign prostatic hyperplasia heterotransplants as an experimental model  

PubMed Central

Benign prostatic hyperplasia is a nonmalignant adenomatous enlargement of the periurethral prostate gland. It is a common disease in older men. In addition to man, spontaneous benign prostatic hyperplasia occurs in chimpanzee and the dog. Alternatives to these spontaneous models are induced benign prostatic hyperplasia, xenografts and in vitro models. Xenografts may be induced by cells cultured in vitro or by the heterotransplantation of primary surgical specimens into immunosuppressed mice. The purpose of this review is to integrate data from more than 30 years of heterotransplantation research in the study of benign hyperplasia of the prostate. Heterotransplantation has provided data regarding the histopathology, morphology, tissue markers, androgen receptor expression, tissue kinetics, take rate and tissue vasculature for this prostate disease. There are advantages, as well as limitations, that have been identified for human prostate disease heterotransplants versus xenotransplantation of cultured cells. Overall, heterotransplanted tissue is better at retaining tissue morphology, pathology, secretory activity, expression of tissue markers and human vasculature of the patient's original specimen. Furthermore, heterotransplanted tissue preserves the three-dimensional tissular architecture of the prostate to maintain critical stromal–epithelial cell interactions.

Lopez-Barcons, Lluis-A

2010-01-01

256

High intensity focused ultrasound in benign prostatic hyperplasia  

Microsoft Academic Search

Benign prostatic hyperplasia (BPH) is an extremely common condition and represents a major health issue in terms of patient numbers and treatment cost. Traditionally, the choice of treatment has been between watchful waiting and surgery, however, the side effects of surgery lead to reluctance for treatment in many men, other than those with severe symptoms and complications. In the last

Nicholas J. Hegarty; John M. Fitzpatrick

1999-01-01

257

Aquaculture in bio-regenerative life support systems (BLSS): Considerations  

NASA Astrophysics Data System (ADS)

A significant amount of research has been invested into understanding the effects of including fish culture in bio-regenerative life support systems (BLSS) for long duration space habitation. While the benefits of fish culture as a sub-process for waste treatment and food production continue to be identified, other pressing issues arise that affect the overall equivalent system mass associated with fish culture in a BLSS. This paper is meant to provide insight into several issues affecting fish culture in a BLSS that will require attention in the future if fish meant for consumption are to be cultured in a BLSS.

Gonzales, John M.

2009-04-01

258

Complement-triggered pathways orchestrate regenerative responses throughout phylogenesis.  

PubMed

Adult tissue plasticity, cell reprogramming, and organ regeneration are major challenges in the field of modern regenerative medicine. Devising strategies to increase the regenerative capacity of tissues holds great promise for dealing with donor organ shortages and low transplantation outcomes and also provides essential impetus to tissue bioengineering approaches for organ repair and replacement. The inherent ability of cells to reprogram their fate by switching into an embryonic-like, pluripotent progenitor state is an evolutionary vestige that in mammals has been retained mostly in fetal tissues and persists only in a few organs of the adult body. Tissue regeneration reflects the capacity of terminally differentiated cells to re-enter the cell cycle and proliferate in response to acute injury or environmental stress signals. In lower vertebrates, this regenerative capacity extends to several organs and remarkably culminates in precise tissue patterning, through cellular transdifferentiation and complex morphogenetic processes that can faithfully reconstruct entire body parts. Many lessons have been learned from robust regeneration models in amphibians such as the newt and axolotl. However, the dynamic interactions between the regenerating tissue, the surrounding stroma, and the host immune response, as it adapts to the actively proliferating tissue, remain ill-defined. The regenerating zone, through a sequence of distinct molecular events, adopts phenotypic plasticity and undergoes rigorous tissue remodeling that, in turn, evokes a significant inflammatory response. Complement is a primordial sentinel of the innate immune response that engages in multiple inflammatory cascades as it becomes activated during tissue injury and remodeling. In this respect, complement proteins have been implicated in tissue and organ regeneration in both urodeles and mammals. Distinct complement-triggered pathways have been shown to modulate critical responses that promote tissue reprogramming, pattern formation, and regeneration across phylogenesis. This article will discuss the mechanistic insights underlying the crosstalk of complement with cytokine and growth factor signaling pathways that drive tissue regeneration and will provide a unified conceptual framework for considering complement modulation as a novel target for regenerative therapeutics. PMID:23684626

Mastellos, Dimitrios C; Deangelis, Robert A; Lambris, John D

2013-05-17

259

Regenerative fuel cells for space and terrestrial use  

NASA Astrophysics Data System (ADS)

Electrolysis, fuel cell, and energy storage technologies are compared and evaluated. The use of a fuel cell and electrolyzer with an immobilized electrolyte is selected as the most promising technique. A comparison of the batteries demonstrates that a RFCS (regenerative fuel cell system) could be a serious competitor in future space activities, especially with increasing power level and energy to be stored. Also, for many terrestrial applications, highly efficient energy storage systems will be of great interest in the near future. Aspects of the terrestrial use of a RFCS are discussed.

Tillmetz, Werner; Dietrich, Guenther; Benz, Uwe

260

A plurality voting method for acquisition of regenerative ranging measurements  

NASA Astrophysics Data System (ADS)

Sequential tone ranging and regenerative ranging may both be considered to consist of two parts: acquisition of the ranging clock phase, from which the range accuracy is derived, and a resolution of the range ambiguity that remains when only the clock period is considered. With sequential tone ranging, the ambiguity is resolved by dividing the frequency of the ranging tone in steps until the remaining ambiguity is resolved by knowledge of the spacecraft position. With regenerative ranging, the ambiguity is resolved by a determination of the phase of a long ranging code. This code phase is determined by both the spacecraft, which then regenerates the code, and by the ground station. It is possible to have sufficient signal-to-noise ratio to provide good range measurement accuracy with regenerative ranging and yet have insufficient signal-to-noise ratio (SNR) to acquire the proper range code phase at the ground station for each individual range measurement. A set of range measurements may be processed together to determine the proper range ambiguity resolution even when none of the individual measurements is reliable. An approach of processing together a set of measurements has been developed and applied to data from the New Horizons mission while the spacecraft was in excess of 22 Astronautical Units from Earth. The value of T*Pr/No was less than 30 dB, making normal processing of the data unreliable. Consistent and correct results have been demonstrated even when the initial range phase values were scattered over the entire possible range of values. This paper will present the method of processing together a set of range measurements and show the application of this method to New Horizons data. The predicted probability of success as a function of the number of available points and the signal-to-noise ratio of the individual points is presented. The SNR required for correct acquisition of the ranging code can be reduced by 15 dB relative to the requirement for indi- idual range measurements when 120 range measurements are processed together. This approach expands the conditions over which regenerative ranging will be successful in deep space missions.

Jensen, J. R.

261

Revisiting the relationship between regenerative ability and aging  

PubMed Central

Contrary to the longstanding view that newts (Notophthalamus viridescens), but not axolotls (Ambystoma mexicanum), can regenerate a lens, a recent report in BMC Biology by Panagiotis Tsonis and colleagues shows axolotls indeed possess this ability during early larval stages. In contrast, they show that zebrafish never posses this ability, even as embryos. This underscores the importance of comparing regenerative ability across species and reinforces the need to consider organ regeneration in the context of evolution, development, and aging. See research article: http://www.biomedcentral.com/1741-7007/10/103

2013-01-01

262

Propellant feed system of a regeneratively cooled scramjet  

SciTech Connect

An expander cycle for an airframe-integrated hydrogen-fueled scramjet is analyzed to study regenerative cooling characteristics and overall specific impulse. Below Mach 10, the specific impulse and thrust coincide with the reference values. At Mach numbers above 10, a reduction of the specific impulse occurs due to the coolant flow rate requirement, which is accompanied by an increase of thrust. It is shown that the thrust may be increased by injecting excess fuel into the combustor to compensate for the decrease of the specific impulse. 9 refs.

Kanda, Takeshi; Masuya, Goro; Wakamatsu, Yoshio (National Aerospace Laboratory, Kakuda (Japan))

1991-04-01

263

Alexandrite-pumped alexandrite regenerative amplifier for femtosecond pulse amplification  

SciTech Connect

We demonstrate a regenerative amplifier incorporating alexandrite as the gain medium that is pumped by an alexandrite laser. Temperature-altered gain permitted the 728-nm alexandrite pump laser, operating at room temperature, to pump a 780{endash}800-nm alexandrite laser that was maintained at elevated temperatures. 200-fs pulses from a Ti:sapphire oscillator were amplified to the millijoule level. This system also amplified femtosecond pulses from a frequency-doubled Er-doped fiber laser. {copyright} {ital 1996 Optical Society of America.}

Hariharan, A.; Fermann, M.E.; Stock, M.L.; Harter, D.J. [IMRA America, Inc., 1044 Woodridge Avenue, Ann Arbor, Michigan 48105 (United States); Squier, J. [Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, California 92093-0339 (United States)

1996-01-01

264

Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis  

PubMed Central

Summary The bone marrow (BM) microenvironment is composed of multiple niche cells that, by producing angiocrine factors, maintain and regenerate the hematopoietic stem cell (HSC) pool (Morrison and Spradling, 2008). We have previously demonstrated that endothelial cells support the proper regeneration of the hematopoietic system following myeloablation (Butler et al., 2010; Hooper et al., 2009; Kobayashi et al., 2010). Here, we demonstrate that expression of the angiocrine factor Jagged-1, supplied by the BM vascular niche, regulates homeostatic and regenerative hematopoiesis through a Notch-dependent mechanism. Conditional deletion of Jagged-1 in endothelial cells (Jag1(ECKO) mice) results in a profound decrease in hematopoiesis and premature exhaustion of the adult HSC pool, while quantification and functional assays demonstrate that loss ofJagged-1 does not perturb vascular or mesenchymal compartments. Taken together, these data demonstrate that the instructive function of endothelial-specific Jagged-1 is required to support the self-renewal and regenerative capacity of HSCs in the adult BM vascular niche.

Poulos, Michael G.; Guo, Peipei; Kofler, Natalie M.; Pinho, Sandra; Gutkin, Michael C.; Tikhonova, Anastasia; Aifantis, Iannis; Frenette, Paul S.; Kitajewski, Jan; Rafii, Shahin; Butler, Jason M.

2013-01-01

265

[Ethical, legal and social issues on regenerative medicine].  

PubMed

There should have been it for the purpose of the severe handling opening meatus for done study after "The law concerning regulation relating to human cloning techniques and other similar techniques" paid its attention to medical utility of "specified embryo", and having forbidden transplantation to prenatal. There is a problem and asks a law and consistency with "The guidelines for handling of specified embryo" it and, despite the duration, does not get skill. If an ES cell, tissue stem cell and human clone embryo can cry in subject of study as the Trinity, it is not possible for those availability and evaluation of safety. Study of regenerative medicine does not consist last if does not use a cell having gamete, germ, an embryo and the specific character which said. We attention to utility of regenerative medicine and takes a national strategic part, correspondence supporting development of steady study is demanded. The result is reduced to its elements in the future by society. PMID:15373219

Tsukata, Yukiyoshi

2004-08-01

266

Adipose tissue-derived cells: from physiology to regenerative medicine.  

PubMed

During the last past years, the importance and the role of adipose tissues have been greatly expanded. After finding that adipose tissues are metabolically very active, the discovery of leptin moved the status of adipose tissue towards an endocrine tissue able to interact with all major organs via secretion of adipokines. Some years ago, the presence of adipocyte precursors, termed preadipocytes, has been described in all adipose tissue depots from various species of different age. More recently, the discovery that different phenotypes can be obtained from stroma cells of adipose tissue has largely emphazised the concept of adipose tissue plasticity. Therefore, raising great hope in regenerative medicine as adipose tissue can be easily harvested in adults it could represent an abundant source of therapeutic cells. Thus, adipose tissue plays the dual role of Mr Obese Hyde as a main actor of obesity and of Dr Regenerative Jekyll as a source of therapeutic cells. Adipose tissue has not yet revealed all its mysteries although one facet could not be well understood without the other one. PMID:17110894

Casteilla, L; Dani, C

2006-11-01

267

Cellular replacement and regenerative medicine therapies in ischemic stroke.  

PubMed

Worldwide, tissue engineering and cellular replacement therapies are at the forefront of the regenerative medicine agenda, and researchers are addressing key diseases, including diabetes, stroke and neurological disorders. It is becoming evident that neurological cell therapy is a necessarily complex endeavor. The brain as a cellular environment is complex, with diverse cell populations, including specialized neurons (e.g., dopaminergic, motor and glutamatergic neurons), each with specific functions. The population also contains glial cells (astrocytes and oligodendrocytes) that offer the supportive network for neuronal function. Neurological disorders have wide and varied pathologies; they can affect predominantly one cell type or a multitude of cell types, which is the case for ischemic stroke. Both neuronal and glial cells are affected by stroke and, depending on the region of the brain affected, different specialized cells are influenced. This review will address currently available therapies and focus on the application and potential of cell replacement, including stem cells and immortalized cell line-derived neurons as regenerative therapies for ischemic stroke, addressing current advances and challenges ahead. PMID:22594330

Thwaites, John W; Reebye, Vikash; Mintz, Paul; Levicar, Natasa; Habib, Nagy

2012-05-01

268

Fuzzy stability analysis of regenerative chatter in milling  

NASA Astrophysics Data System (ADS)

During machining, unstable self-excited vibrations known as regenerative chatter can occur, causing excessive tool wear or failure, and a poor surface finish on the machined workpiece. Consequently it is desirable to predict, and hence avoid the onset of this instability. Regenerative chatter is a function of empirical cutting coefficients, and the structural dynamics of the machine-tool system. There can be significant uncertainties in the underlying parameters, so the predicted stability limits do not necessarily agree with those found in practice. In the present study, fuzzy arithmetic techniques are applied to the chatter stability problem. It is first shown that techniques based upon interval arithmetic are not suitable for this problem due to the issue of recursiveness. An implementation of fuzzy arithmetic is then developed based upon the work of Hanss and Klimke. The arithmetic is then applied to two techniques for predicting milling chatter stability: the classical approach of Altintas, and the time-finite element method of Mann. It is shown that for some cases careful programming can reduce the computational effort to acceptable levels. The problem of milling chatter uncertainty is then considered within the framework of Ben-Haim's information-gap theory. It is shown that the presented approach can be used to solve process design problems with robustness to the uncertain parameters. The fuzzy stability bounds are then compared to previously published data, to investigate how uncertainty propagation techniques can offer more insight into the accuracy of chatter predictions.

Sims, Neil D.; Manson, Graeme; Mann, Brian

2010-04-01

269

Therapeutic Potential of Mesenchymal Stem Cells in Regenerative Medicine  

PubMed Central

Mesenchymal stem cells (MSCs) are stromal cells that have the ability to self-renew and also exhibit multilineage differentiation into both mesenchymal and nonmesenchymal lineages. The intrinsic properties of these cells make them an attractive candidate for clinical applications. MSCs are of keen interest because they can be isolated from a small aspirate of bone marrow or adipose tissues and can be easily expanded in vitro. Moreover, their ability to modulate immune responses makes them an even more attractive candidate for regenerative medicine as allogeneic transplant of these cells is feasible without a substantial risk of immune rejection. MSCs secrete various immunomodulatory molecules which provide a regenerative microenvironment for a variety of injured tissues or organ to limit the damage and to increase self-regulated tissue regeneration. Autologous/allogeneic MSCs delivered via the bloodstream augment the titers of MSCs that are drawn to sites of tissue injury and can accelerate the tissue repair process. MSCs are currently being tested for their potential use in cell and gene therapy for a number of human debilitating diseases and genetic disorders. This paper summarizes the current clinical and nonclinical data for the use of MSCs in tissue repair and potential therapeutic role in various diseases.

Patel, Devang M.; Shah, Jainy; Srivastava, Anand S.

2013-01-01

270

METHODS TO VALIDATE TOOTH-SUPPORTING REGENERATIVE THERAPIES  

PubMed Central

SUMMARY In humans, microbially-induced inflammatory periodontal diseases are the primary initiators that disrupt the functional and structural integrity of the periodontium (i.e., the alveolar bone, the periodontal ligament, and the cementum). The re-establishment of its original structure, properties and function constitutes a significant challenge in the development of new therapies to regenerate tooth-supporting defects. Preclinical models represent an important in vivo tool to critically evaluate and analyze key aspects of novel regenerative therapies including: 1) Safety, 2) Effectiveness, 3) Practicality, and 4) Functional and structural stability over time. Therefore, these models provide foundational data that supports the clinical validation and the development of novel innovative regenerative periodontal technologies. Steps are provided on the use of the root fenestration animal model for the proper evaluation of periodontal outcome measures using the following parameters: descriptive histology, histomorphometry, immunostaining techniques, three-dimensional imaging, electron microscopy, gene expression analyses and safety assessments. These methods will prepare investigators and assist them in identifying key endpoints that can then be adapted to later stage human clinical trials.

Padial-Molina, Miguel; Marchesan, Julie T.; Taut, Andrei D.; Jin, Qiming; Giannobile, William V.; Rios, Hector F.

2012-01-01

271

Raised 17-hydroxyprogesterone levels in congenital adrenal hyperplasia.  

PubMed

Congenital adrenal hyperplasia (CAH) refers to autosomal recessive diseases resulting from deficiency of enzymes involved in the production of cortisol by the adrenal glands. This study was designed to determine the frequency of suspected congenital adrenal hyperplasia patients by evaluating the laboratory data of blood 17-OHP. The study was conducted at Chemical Pathology Section of Department of Pathology at the Aga Khan University, Karachi. The basic demographic data of 2282 subjects was recorded, screened for blood 17-OHP levels from January 2007 to December 2010. A cutoff of ³ 4 ng/ml was considered as suggestive of CAH. The results showed 17-OHP levels ³ 4 ng/ml were found predominantly among infants (14.4%) and in females (18.2%). PMID:23673184

Iqbal, Sahar; Khan, Aysha Habib

2013-05-01

272

Pituitary hyperplasia secondary to acquired hypothyroidism: case report  

PubMed Central

Objective and Importance despite recent progress in imaging, it is still difficult to distinguish between pituitary adenoma and hyperplasia, even using Magnetic Resonance Imaging (MRI) with gadolinium injection. We describe an example of reactive pituitary hyperplasia from primary hypothyroidism that mimicked a pituitary macroadenoma in a child. Clinical Presentation a 10 year old boy presented with headache and statural growth arrest. MRI revealed an intrasellar and suprasellar pituitary mass. Endocrine evaluation revealed primary hypothyroidism. Intervention the patient was started on levothyroxine with resolution of the mass effect. Conclusion primary hypothyroidism should be considered in the differential diagnosis of solid mass lesions of the pituitary gland. Examination of thyroid function in patients with sellar and suprasellar masses revealed by MRI may avoid unnecessary operations which can cause irreversible complications.

2011-01-01

273

Association between Klinefelter syndrome and focal nodular hyperplasia.  

PubMed

Focal nodular hyperplasia is a benign lesion of the liver, predominantly affecting women. Its etiology is unknown. Elevated levels of estrogens have been invoked to play a role in the disease. Klinefelter syndrome is the most common sex chromosome disorder, characterized by 47, XXY karyotype, resulting in male hypogonadism and sex hormone imbalance. We present a case of a 25-year-old man affected by Klinefelter syndrome, admitted to our hospital for aspecific dyspeptic symptoms. During admission he underwent: blood test for the liver function and sexual hormonal status, ultrasonography, echo color power Doppler and computerized tomography scan of the liver, and liver biopsy. A hypergonadotropic hypogonadism was present. Imaging of the liver showed an hepatic lesion that liver biopsy confirmed to be a focal nodular hyperplasia. Although the association could be casual, the sex hormone imbalance present in Klinefelter syndrome may suggest a role in the development of this benign liver lesion. PMID:12869895

Santarelli, Luca; Gabrielli, Maurizio; Orefice, Ruggero; Nista, Enrico C; Serricchio, Michele; Nestola, Manuela; Rapaccini, GianLudovico; De Ninno, Maria; Pola, Paolo; Gasbarrini, Giovanni; Gasbarrini, Antonio

2003-08-01

274

[Disorders of kidney function in patients with benign prostatic hyperplasia].  

PubMed

The examination of 648 males aged 50 to 86 to conduct an early outpatient detection of renal dysfunction in the elderly men employed an original technique of renal function assessment based on the kinetics of urinary 5-NOK elimination. Renal dysfunctions were revealed in 165 patients, in 159 of them the underlying cause was benign prostatic hyperplasia. The results were compared with those obtained at radionuclide tracing and Reberg-Tareev test. The correlation found indicated the authors' technique informative value and its compatibility with the above methods. Identification of renal dysfunction at early stages of benign prostatic hyperplasia allowed their timely hospitalization and operative treatment which enables the physicians to prevent progression of chronic renal failure in these patients. PMID:9461783

Rodoman, V E; Avdoshin, V P; Andriukhin, M I

275

Clinical outcomes of childhood x-irradiation for lymphoid hyperplasia  

SciTech Connect

A prospective study was conducted to explore the relationship between childhood x-irradiation for lymphoid hyperplasia and the subsequent development of thyroid gland and other head and neck disorders. All individuals under 18 years of age who were x-irradiated for lymphoid hyperplasia during the years 1938-69 at Children's Hospital Medical Center, Boston comprised the exposed population. The comparison group consisted of non-exposed, surgically treated individuals. The study included a health questionnaire and a clinical examination component. A history of thyroid cancer was reported by 11 exposed subjects and no non-exposed subjects. Significantly elevated standardized incidence ratios of thyroid cancer were seen for both exposed males and females, 19.9 and 12.1, respectively. The average thyroid radiation dose was 25.8 rads and the mean latency period was 17.3 years.

Pottern, L.M.

1987-01-01

276

Prenatal treatment of congenital adrenal hyperplasia: risks outweigh benefits.  

PubMed

Prenatal treatment of congenital adrenal hyperplasia by administering dexamethasone to a woman presumed to be carrying an at-risk fetus has been described as safe and effective in several reports. A review of data from animal experimentation and human trials indicates that first-trimester dexamethasone decreases birthweight; affects renal, pancreatic beta cell, and brain development; increases anxiety; and predisposes to adult hypertension and hyperglycemia. In human studies, first-trimester dexamethasone is associated with orofacial clefts, decreased birthweight, poorer verbal working memory, and poorer self-perception of scholastic and social competence. Numerous medical societies have cautioned that prenatal treatment of congenital adrenal hyperplasia with dexamethasone should only be done in prospective clinical research settings with institutional review board approval, and therefore is not appropriate for routine community practice. PMID:23123167

Miller, Walter L; Witchel, Selma Feldman

2012-10-31

277

Reactive lymphoid hyperplasia 1 month after LASIK surgery  

Microsoft Academic Search

Purpose  This study was conducted to investigate a case of reactive lymphoid hyperplasia following laser assisted in situ keratomileusis\\u000a (LASIK).\\u000a \\u000a \\u000a \\u000a Methods  A 31-year-old man who underwent LASIK presented 1 month later with a fleshy conjunctival (plical) tumor in the left eye. An\\u000a excision biopsy of the tumor was performed.\\u000a \\u000a \\u000a \\u000a Results  Histopathology of the excised tumor revealed reactive lymphoid hyperplasia.\\u000a \\u000a \\u000a \\u000a Discussion  Conjunctival lymphomas can masquerade

Shantan Reddy; Paul T. Finger; Emil W. Chynn; Codrin E. Iacob

2006-01-01

278

External Factors, Produced by Growing Nerves, Trigger a Regenerative Response in a Non-Regenerative Central Nervous System: Purification and Mode of Action.  

National Technical Information Service (NTIS)

Mammalian central nervous system (CNS) neurons have a negligible post-traumatic regenerative capacity while the nerves of lower vertebrates, as well as the peripheral nervous system (PNS) of mammals regenerate spontaneously after injury. Studies carried o...

M. Schwartz

1988-01-01

279

Alcohol Consumption, Cigarette Smoking, and Risk of Benign Prostatic Hyperplasia  

Microsoft Academic Search

Alcohol consumption and cigarette smoking were evaluated in relation to development of benign prostatic hyperplasia (BPH) among 29,386 members of the Health Professionals Follow-up Study. Men who were 40-75 years old in 1986 and free of prior BPH surgery, diagnosed cancer at baseline, and prostate cancer at baseline and during follow-up were followed for incidence of BPH surgery from 1986

Elizabeth A. Plate; Eric B. Rimm; Ichiro Kawachi; Graham A. Coldite; Meir J. Stampfer; Walter C. Willett; Edward Giovannucci

280

Sebaceous Hyperplasia of the Scrotum and Penile Shaft  

PubMed Central

Sebaceous hyperplasia (SH) is a proliferative abnormality of sebaceous glands, most often seen in elderly individuals. It consists of single or multiple, asymptomatic, small yellow papules with a central depression. The face is most commonly affected, but there have been reports of SH on the chest or genitalia. A lobular array of well-differentiated mature sebaceous lobules is noted on histological preparations. In this report, we describe a patient with SH on the penile shaft and parts of the scrotum.

Kim, Hei Sung; Lee, Jun Young; Kim, Hyung Ok

2011-01-01

281

Hypertrophy and\\/or Hyperplasia: Dynamics of Adipose Tissue Growth  

Microsoft Academic Search

Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Genetics and diet affect the relative contributions of these two mechanisms to the growth of adipose tissue in obesity. In this study, the size distributions of epididymal adipose cells from two mouse strains, obesity-resistant FVB\\/N and obesity-prone C57BL\\/6, were measured after 2, 4, and 12

Junghyo Jo; Oksana Gavrilova; Stephanie Pack; William Jou; Shawn Mullen; Anne E. Sumner; Samuel W. Cushman; Vipul Periwal

2009-01-01

282

Sexual function in patients with benign prostatic hyperplasia  

Microsoft Academic Search

Sexual health has significant impact on quality of life among men with benign prostatic hyperplasia (BPH). The degree of sexual\\u000a dysfunction matches the severity of lower urinary tract symptoms (LUTS). Treatment of BPH affects not only LUTS, but sexual\\u000a function as well. Medical, surgical, and minimally invasive therapies differ in their effect on erectile function, ejaculation,\\u000a and sexual satisfaction. Choice

Paul K. Hegarty; Nicholas J. Hegarty; John M. Fitzpatrick

2001-01-01

283

Growth factors in benign prostatic hyperplasia: Basic science implications  

Microsoft Academic Search

Benign prostatic hyperplasia (BPH) is the most common proliferative disease of the prostate of men in the United States. The\\u000a histopathology of BPH strongly implicates local paracrine and autocrine growth factors and inflammatory cytokines in its pathogenesis.\\u000a A complex milieu of growth-regulatory proteins includes members of the fibroblast, insulin-like, and transforming growth factor\\u000a families. It appears that these proteins and

M. Scott Lucia; James R. Lambert

2007-01-01

284

Vaginal hyperplasia in the bitch: Literature review and commentary  

PubMed Central

We reviewed the incidence, etiology, clinical presentations, diagnosis, treatments and prevention of canine vaginal hyperplasia, and describe a simple surgical technique for its correction as practiced at the Small Animal Clinic, State University of Utrecht, The Netherlands. Many different treatments have been used, and some are novel approaches. In many cases, prevention is accomplished if the bitch is ovariectomized; there is a high incidence of recurrence with medical treatment.

Post, Klaas; Van Haaften, Bas; Okkens, Auke C.

1991-01-01

285

Cutaneous Papillomatous Hyperplasia in Cyclosporine-A Treated Beagles  

Microsoft Academic Search

All twelve Beagle dogs undergoing long-term therapy (26 weeks) with the immunosuppressive drug cyclosporine-A (30 mg\\/kg), developed cutaneous papillomatous hyperplasia. By week 7 all dogs developed generalized lesions distributed over the entire body. These occurred as irregular, oval, sessile, unpigmented, firm masses. The incidence and severity of the skin lesions varied among dogs and anatomic site, with no correlation to

Werner Seibel; John P. Sundberg; Lawrence J. Lesko; John J. Sauk; Leslie B. McCleary; Thomas M. Hassell

1989-01-01

286

Evaluation of Adrenomedullary Function in Patients with Congenital Adrenal Hyperplasia  

Microsoft Academic Search

Background\\/Aims: Congenital adrenal hyperplasia (CAH) is characterized by adrenal insufficiency with or without salt wasting. It is also accompanied by adrenomedullary hypofunction. The aim of the present study was to investigate adrenomedullary function in patients with CAH due to 21-hydroxylase and 11?-hydroxylase deficiencies and in age-matched normal subjects. Methods: We measured plasma catecholamines (epinephrine and norepinephrine) and urine metanephrine in

Filiz Tutunculer; Nurcin Saka; Selda Can Arkaya; Semra Abbasoglu; Firdevs Bas

2009-01-01

287

Management of Congenital Adrenal Hyperplasia: Results of the ESPE Questionnaire  

Microsoft Academic Search

The management of children and adolescents with congenital adrenal hyperplasia (CAH) remains difficult. To assess the current European practice in diagnosis and management of CAH, an ESPE (European Society for Paediatric Endocrinology) survey was circulated in 2000\\/2001. The questionnaire was answered by 34% of ESPE members, representing 125 institutions which cared for 6,553 CAH patients. Paediatric endocrinologists, surgeons, gynaecologists, geneticists,

Felix G. Riepe; Nils Krone; Matthias Viemann; Carl-Joachim Partsch; Wolfgang G. Sippell

2002-01-01

288

Overview of interventional treatment options for benign prostatic hyperplasia  

PubMed Central

Transurethral resection of the prostate (TURP) remains the gold standard surgical intervention for men with benign prostatic hyperplasia (BPH). However, there are other, newer technologies that have also demonstrated safety and efficacy at least equivalent to that of TURP (e.g., Holmium laser, photoselective vaporization of the prostate). These minimally invasive techniques may be particularly useful for selected patient populations (e.g., those on anticoagulant therapy).

Elhilali, Mostafa M.

2012-01-01

289

New Advances in Benign Prostatic Hyperplasia: Laser Therapy  

Microsoft Academic Search

Throughout the past decade, numerous techniques for the treatment of benign prostatic hyperplasia have emerged. Laser therapy,\\u000a in particular, has gained widespread popularity among urologists. Since its inception in 1996, holmium laser enucleation of\\u000a the prostate (HoLEP) has been evaluated rigorously in the treatment of glands of all sizes. HoLEP has produced superior relief\\u000a of bladder outlet obstruction as compared

Jessica Mandeville; Ehud Gnessin; James E. Lingeman

2011-01-01

290

Regenerative-braking sliding mode control of electric vehicle based on neural network identification  

Microsoft Academic Search

Aiming at the main problems of electric vehicle (EV): short driving range, short life of batteries, and variation of model parameters, based on constructing the main circuit diagram of the EVpsilas control system, the mathematical model of regenerative-braking process was established, and a novel regenerative-braking controller was designed, which combined neural network (NN) with traditional sliding mode controller (SMC). The

Jianbo Cao; Binggang Cao; Peng Xu; Zhifeng Bai

2008-01-01

291

Regenerative Medicine and New Labour life science policy: rhetorics of success, narratives of sustainability and survival  

Microsoft Academic Search

Advances in stem cell science and tissue engineering are being turned into applications and products through a novel medical paradigm known as regenerative medicine. This paper begins by examining the vulnerabilities and risks encountered by the regenerative medicine industry during a pivotal moment in its scientific infancy: the 2000s. Under the auspices of New Labour, British medical scientists and life

B. Kewell; M. Beck

2011-01-01

292

Analysis of the regenerative brake system parameters for concrete mixing truck basded on AMESim  

Microsoft Academic Search

This article describes the concrete truck's hydraulic regenerative braking system structure, working mechanism, matching principle, and the relevant dynamic model. In order to achieve the purpose of simulating regenerative braking system, the software AMESim was used to establish physical model. By the target vehicle torque control strategy, according to the real parameters of the tuck, hydraulic parameters of secondary element

Cui Zhang; Xinhui Liu; Zhan Wang; Qiang Shi

2011-01-01

293

Study on the Mode of Power Plant Circulating Water Waste Heat Regenerative Thermal System  

Microsoft Academic Search

Power plant circulating water (PPCW) waste heat recycling is an important way of increasing a power plant's primary energy ratio. According to the PPCW waste heat regenerative thermal system, the authors propose two modes of heat pump heat regenerative of the system, and establish mathematical models for energy saving critical points. Through comparative study and analysis in actual case, the

Bi Qingsheng; Ma Yanliang; Yang Zhifu

2009-01-01

294

On regenerative power management in more electric aircraft (MEA) power system  

Microsoft Academic Search

This paper discusses three power system topologies that are capable of handling regenerative power in EMA loads for more electric aircraft (MEA). A simple power system including a synchronous generator, an electromechanical actuator (EMA) and an electric accumulator unit (EAU) is builtto show the effectiveness of regenerative power management using EAU.

Thomas X. Wu; Jon Zumberge; Mitch Wolff

2011-01-01

295

Ultrasonography and cystic hyperplasia-pyometra complex in the bitch.  

PubMed

Cystic endometrial hyperplasia-pyometra complex is the most frequent and important endometrial disorder encountered in bitches. The pathogenesis of the disease is related to the activity of progesterone [Feldman and Nelson, Canine and Feline Endocrinology and Reproduction (1996) W.B. Saunders, Philadelphia]. Cystic endometrial hyperplasia (CEH) is an abnormal response of the bitch's uterus to ovarian hormones [De Bosschere et al. Theriogenology (2001) 55, 1509]. CEH is considered by many authors to be an exaggerated response of the uterus to chronic progestational stimulation during the luteal phase of the oestrous cycle, causing an abnormal accumulation of fluid within the endometrial glands and uterine lumen (De Bosschere et al. 2001). The resulting lesions of pyometra are due to the interaction between bacteria and hormones. The aim of this study was to evaluate if transabdominal uterine ultrasonography can be a useful and reliable diagnostic method to confirm Dow's [Veterinary Record (1958) 70, 1102] and De Bosschere's histopathological classification of CEH-pyometra complex. The study was carried out on 45 bitches with pyometra, 10 purebreds and 35 crossbreeds, 1-15 years old, 20% of which had whelped at least once. None of these animals had received exogenous oestrogen or progesterone treatment. On admission the 45 animals were in the luteal phase of the oestrus cycle. Clinical signs, blood parameters, uterine ultrasonography, bacterial swabs and uterine histopathological results were recorded. Results suggest that ultrasonographic examination is a useful and reliable tool for the diagnosis of cystic endometrial hyperplasia. PMID:15182288

Bigliardi, E; Parmigiani, E; Cavirani, S; Luppi, A; Bonati, L; Corradi, A

2004-06-01

296

Social dominance in tilapia is associated with gonadotroph hyperplasia.  

PubMed

Tilapias are emerging as one of the most important fish in worldwide aquaculture and are also widely used as model fish in the study of reproduction and behavior. During the reproductive season, male tilapia are highly territorial and form spawning pits in which the dominant males court and spawn with available females. Non-territorial males stand a much lower chance of reproducing. Using transgenic tilapia in which follicle stimulating hormone (FSH) gonadotrophs were fluorescently labeled with enhanced green fluorescent protein (EGFP), we studied the effect of social dominance on the hormonal profile and pituitary cell populations in dominant and non-dominant males. Immunofluorescence studies showed that FSH-EGFP-transgenic fish reliably express EGFP in FSH-secreting cells. EGFP expression pattern differed from that of luteinizing hormone. Dominant males had larger gonads as well as higher levels of androgens and gonadotropins in the plasma. Pituitaries of dominant males exhibited higher gonadotropin content and gene expression. Flow cytometry revealed pituitary hyperplasia as well as FSH cell hyperplasia and increased granulation. Taken together, these findings suggest that gonadotroph hyperplasia as well as increased production by individual cells underlie the increased reproductive activity of dominant tilapia males. PMID:23660448

Golan, Matan; Levavi-Sivan, Berta

2013-05-06

297

Development of a co-operative control algorithm during regenerative braking for a fuel cell electric vehicle  

Microsoft Academic Search

In this study, a regenerative braking control algorithm was developed for the fuel cell electric vehicle (FCEV) equipped with the front electronic wedge brake (EWB). A regenerative braking control algorithm was proposed for the regenerative braking and friction braking for the front wheels, and for the friction braking for the rear wheels; and a powertrain model of an FCEV composed

Jiweon Ko; Jungwook Kim; Gaeun Lee; Sunggon Byun; Dongyoon Hyun; Hyunsoo Kim

2011-01-01

298

Smooth Muscle Hyperplasia in an Asthmatic Patient: Do We Know It All?  

Microsoft Academic Search

Bronchial smooth muscle hyperplasia is a well-known structural change in asthma. The degree of hyperplasia is related to asthma severity. We report a case of extreme smooth muscle hyperplasia in an asthmatic patient. A 54-year-old female with a diagnosis of analgesic-induced asthma was admitted to our center for nasal polyposis surgery. During her preoperative evaluation, atelectasis of the right middle

Begum Ergan-Arsava; Gul Karakaya; Pinar Firat; A. Fuat Kalyoncu

2011-01-01

299

Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms  

Microsoft Academic Search

We initiated a transgenic model for primary pulmonary neuroendocrine cell (PNEC) hyperplasia\\/neoplasia using v-Ha-ras driven by the neural\\/neuroendocrine (NE)-specific calcitonin promoter (rascal). Previously, we showed that nitrosamine treated rodents develop PNEC hyperplasia but non-NE lung tumors, with variable outcomes presumably reflecting ras activation in multiple cell lineages. Interestingly, all rascal transgenic mouse lineages develop hyperplasias of NE and non-NE cells

Mary E Sunday; Kathleen J Haley; Kristan Sikorski; Sherry A Graham; Rodica L Emanuel; Fan Zhang; QiQi Mu; Aliakbar Shahsafaei; Dimitrios Hatzis

1999-01-01

300

Regenerative medicine for the treatment of heart disease.  

PubMed

Heart failure is a major cause of mortality worldwide with a steady increase in prevalence. There is currently no available cure beyond orthotopic heart transplantation, which for a number of reasons is an option only for a small fraction of all patients. Considerable hope has therefore been placed on the possibility of treating a failing heart by replacing lost cardiomyocytes, either through transplantation of various types of stem cells or by boosting endogenous regenerative mechanisms in the heart. Here, we review the current status of stem and progenitor cell-based therapies for heart disease. We discuss the pros and cons of different stem and progenitor cell types that can be considered for transplantation and describe recent advances in the understanding of how cardiomyocytes normally differentiate and how these cells can be generated from more immature cells ex vivo. Finally, we consider the possibility of activation of endogenous stem and progenitor cells to treat heart failure. PMID:23331408

Hansson, E M; Lendahl, U

2013-02-10

301

Cell fusion: biological perspectives and potential for regenerative medicine.  

PubMed

Cell fusion has emerged as a powerful subject of debate in the last few years. Adult stem cell plasticity and the search for mechanisms to explain this process have led to the "rediscovery" of cell fusion. In nature, cell fusion is a normal process involved in sexual reproduction, tissue formation, and immune response. The recent observation that bone marrow derived cells fuse with several cell types introduces new and provocative questions. In this review, I shall recapitulate what is known about cell fusion and discuss its more controversial aspects. I shall highlight the most exciting open questions; its biological potential; pros and cons; and their implications on stem cell plasticity, regenerative medicine, and development. PMID:17127279

Alvarez-Dolado, Manuel

2007-01-01

302

Regenerative oscillation and four-wave mixing in graphene optoelectronics  

NASA Astrophysics Data System (ADS)

The unique linear and massless band structure of graphene in a purely two-dimensional Dirac fermionic structure has led to intense research in fields ranging from condensed matter physics to nanoscale device applications covering the electrical, thermal, mechanical and optical domains. Here, we report three consecutive first observations in graphene-silicon hybrid optoelectronic devices--ultralow-power resonant optical bistability, self-induced regenerative oscillations and coherent four-wave mixing--all at few-femtojoule cavity recirculating energies. These observations, in comparison with control measurements on solely monolithic silicon cavities, are enabled only by the dramatically large and ultrafast ?(3) nonlinearities in graphene and the large Q/V ratios in wavelength-localized photonic crystal cavities. These third-order nonlinear results demonstrate the feasibility and versatility of hybrid two-dimensional graphene-silicon nanophotonic devices for next-generation chip-scale high-speed optical communications, radiofrequency optoelectronics and all-optical signal processing.

Gu, T.; Petrone, N.; McMillan, J. F.; van der Zande, A.; Yu, M.; Lo, G. Q.; Kwong, D. L.; Hone, J.; Wong, C. W.

2012-08-01

303

Stem cell recruitment after injury: lessons for regenerative medicine  

PubMed Central

Tissue repair and regeneration are thought to involve resident cell proliferation as well as the selective recruitment of circulating stem and progenitor cell populations through complex signaling cascades. Many of these recruited cells originate from the bone marrow, and specific subpopulations of bone marrow cells have been isolated and used to augment adult tissue regeneration in preclinical models. Clinical studies of cell-based therapies have reported mixed results, however, and a variety of approaches to enhance the regenerative capacity of stem cell therapies are being developed based on emerging insights into the mechanisms of progenitor cell biology and recruitment following injury. This article discusses the function and mechanisms of recruitment of important bone marrow-derived stem and progenitor cell populations following injury, as well as the emerging therapeutic applications targeting these cells.

Rennert, Robert C; Sorkin, Michael; Garg, Ravi K; Gurtner, Geoffrey C

2013-01-01

304

An antiaging and regenerative medicine approach to optimal skin health.  

PubMed

The optimal health and appearance of the skin is the result of several factors: extrinsic aging (UV damage), intrinsic aging (genetics, lifestyle), and hormonal aging (primarily estrogen loss). This article intends to take an antiaging and regenerative medicine approach to the aging skin and focus on both the hormonal causes and the intrinsic causes of aging; namely, hormones, diet, and lifestyle. By taking a functional approach to the evaluation and treatment of the skin, we hope to elucidate the causation of the condition of the skin and provide targeted treatments to improve its quality. We will sequentially cover the topics of hormonal decline and the skin, understanding hormone replacement, aging and the skin, and key nutrients for youthful skin. We hope to provide a more comprehensive approach to treating the aging face and skin that will provide patients with more long-lasting and youthful results. PMID:21246454

Pontius, Allison T; Smith, Pamela W

2011-01-18

305

Transient Regenerative Potential of the Neonatal Mouse Heart  

PubMed Central

Certain fish and amphibians retain a robust capacity for cardiac regeneration throughout life, but the same is not true of the adult mammalian heart. Whether the capacity for cardiac regeneration is absent in mammals or whether it exists and is switched off early after birth has been unclear. We found that the hearts of 1-day-old neonatal mice can regenerate after partial surgical resection, but this capacity is lost by 7 days of age. This regenerative response in 1-day-old mice was characterized by cardiomyocyte proliferation with minimal hypertrophy or fibrosis, thereby distinguishing it from repair processes. Genetic fate mapping indicated that the majority of cardiomyocytes within the regenerated tissue originated from preexisting cardiomyocytes. Echocardiography performed 2 months after surgery revealed that the regenerated ventricular apex had normal systolic function. Thus, for a brief period after birth, the mammalian heart appears to have the capacity to regenerate.

Porrello, Enzo R.; Mahmoud, Ahmed I.; Simpson, Emma; Hill, Joseph A.; Richardson, James A.; Olson, Eric N.; Sadek, Hesham A.

2011-01-01

306

Transient regenerative potential of the neonatal mouse heart.  

PubMed

Certain fish and amphibians retain a robust capacity for cardiac regeneration throughout life, but the same is not true of the adult mammalian heart. Whether the capacity for cardiac regeneration is absent in mammals or whether it exists and is switched off early after birth has been unclear. We found that the hearts of 1-day-old neonatal mice can regenerate after partial surgical resection, but this capacity is lost by 7 days of age. This regenerative response in 1-day-old mice was characterized by cardiomyocyte proliferation with minimal hypertrophy or fibrosis, thereby distinguishing it from repair processes. Genetic fate mapping indicated that the majority of cardiomyocytes within the regenerated tissue originated from preexisting cardiomyocytes. Echocardiography performed 2 months after surgery revealed that the regenerated ventricular apex had normal systolic function. Thus, for a brief period after birth, the mammalian heart appears to have the capacity to regenerate. PMID:21350179

Porrello, Enzo R; Mahmoud, Ahmed I; Simpson, Emma; Hill, Joseph A; Richardson, James A; Olson, Eric N; Sadek, Hesham A

2011-02-25

307

Solar powered water desalination system with a regenerative fixture  

SciTech Connect

A low pressure, low temperature, solar powered evaporating condensation system to provide relatively large scale conversion of brackish and seawater to fresh water, utilizes a solar radiation frequency selective material covered evaporation chamber, a throat connected elevated condenser containing energy transferring devices for vapor volume reduction to form a condensate which flows through a water-locked barometric leg to maintain the system at the sub-atmospheric pressure. The system is regenerative and includes means whereby the energy removed from the vapor during condensation is returned to the evaporating chamber and is again utilized in the cycle. Egress valves and locks are provided to maintain balanced flow of raw water, condensate and ejection of residuals. Suitable elevation of the condenser above the evaporator would provide for power generation.

Mckeen, J.E.

1980-11-25

308

Regenerative Therapy After Cancer: What Are the Risks?  

PubMed Central

There is often a pressing need for reconstruction after cancer surgery. Regenerative therapy holds the promise of more natural and esthetic functional tissue. In the case of breast reconstruction postmastectomy, volume retention problems associated with autologous fat transfer could be ameliorated by augmentation with cells capable mediating rapid vascularization of the graft. Intentional placement of regenerating tissue at the site of tumor resection raises questions concerning the possibility of promoting cancer recurrence. Here we review coculture and animal models of tumor/mesenchymal stem cell interactions under regenerating conditions. Available evidence from case reports, cell lines, and clinical isolates favors the interpretation that regenerating tissue promotes the growth of active, high-grade tumor. In contrast, dormant cancer cells do not appear to be activated by the complex signals accompanying wound healing and tissue regeneration, suggesting that engineered tissue reconstruction should be deferred until cancer remission has been firmly established.

Zimmerlin, Ludovic; Rubin, Joseph Peter; Donnenberg, Albert D.

2010-01-01

309

QPSK/SQPSK modulators in advanced technology for regenerative repeaters  

NASA Astrophysics Data System (ADS)

This paper presents QPSK and SQPSK modulators for use in regenerative satellite repeaters. Design considerations, realization and modulator performance are described. Much effort has been concentrated on size and mass reduction of conventional satellite PSK modulators. The approaches finally adopted use a compact MIC circuit for the microwave part and a single custom IC for the digital part. The modulators are designed for a center frequency of 15 GHz and a bit rate of 300 Mbps. Measured phase and amplitude deviations at room temperature are below 1.6 deg and 0.25 dB, respectively. The extremely short phase transition times of less than 0.6 nsec allow operation of the modulators up to 660 Mbps. Implemented in a 120-Mbps QPSK test system, the modulators show bit-error-rate degradations of 0.5 dB and 0.25 dB, respectively.

Alberty, Michael; Spinnler, Matthias; Ohm, Gerhard

1990-11-01

310

Developmental and Regenerative Biology of Multipotent Cardiovascular Progenitor Cells  

PubMed Central

Our limited ability to improve the survival of patients with heart failure is due, in part, to the inability of the mammalian heart to meaningfully regenerate itself. The recent identification of distinct families of multipotent cardiovascular progenitor cells from endogenous as well as exogenous sources, such as embryonic and induced pluripotent stem cells, has raised much hope that therapeutic manipulation of these cells may lead to regression of many forms of cardiovascular disease. While the exact source and cell type remains to be clarified, our greater understanding of the scientific underpinning behind developmental cardiovascular progenitor cell biology has helped to clarify the origin and properties of diverse cells with putative cardiogenic potential. In this review, we highlight recent advances in the understanding of cardiovascular progenitor cell biology from embryogenesis to adulthood and their implications for therapeutic cardiac regeneration. We believe that a detailed understanding of cardiogenesis will inform future applications of cardiovascular progenitor cells in heart failure therapy and regenerative medicine.

Sturzu, Anthony C.; Wu, Sean M.

2011-01-01

311

Developmental and regenerative biology of multipotent cardiovascular progenitor cells.  

PubMed

Our limited ability to improve the survival of patients with heart failure is attributable, in part, to the inability of the mammalian heart to meaningfully regenerate itself. The recent identification of distinct families of multipotent cardiovascular progenitor cells from endogenous, as well as exogenous, sources, such as embryonic and induced pluripotent stem cells, has raised much hope that therapeutic manipulation of these cells may lead to regression of many forms of cardiovascular disease. Although the exact source and cell type remains to be clarified, our greater understanding of the scientific underpinning behind developmental cardiovascular progenitor cell biology has helped to clarify the origin and properties of diverse cells with putative cardiogenic potential. In this review, we highlight recent advances in the understanding of cardiovascular progenitor cell biology from embryogenesis to adulthood and their implications for therapeutic cardiac regeneration. We believe that a detailed understanding of cardiogenesis will inform future applications of cardiovascular progenitor cells in heart failure therapy and regenerative medicine. PMID:21293007

Sturzu, Anthony C; Wu, Sean M

2011-02-01

312

Regenerative braking device with rotationally mounted energy storage means  

DOEpatents

A regenerative braking device for an automotive vehicle includes an energy storage assembly (12) having a plurality of rubber rollers (26, 28) mounted for rotation between an input shaft (30) and an output shaft (32), clutches (50, 56) and brakes (52, 58) associated with each shaft, and a continuously variable transmission (22) connectable to a vehicle drivetrain and to the input and output shafts by the respective clutches. In a second embodiment the clutches and brakes are dispensed with and the variable ratio transmission is connected directly across the input and output shafts. In both embodiments the rubber rollers are torsionally stressed to accumulate energy from the vehicle when the input shaft rotates faster or relative to the output shaft and are torsionally relaxed to deliver energy to the vehicle when the output shaft rotates faster or relative to the input shaft.

Hoppie, Lyle O. (Birmingham, MI)

1982-03-16

313

Corticosteroids reduce regenerative repair of epithelium in experimental gastric ulcers.  

PubMed Central

The association between corticosteroid treatment and gastric ulcer healing is controversial. The effects of corticosteroids on experimental ulcer healing in the rat were studied and the effect of coadministration of a prostaglandin E1 analogue was determined. Forty male adult rats were divided into five groups and pretreated for 10 days as follows: (a) control, (b) prednisolone (10 mg/kg), (c) prednisolone and misoprostol (300 micrograms/kg), (d) misoprostol, and (e) indomethacin (2 mg/kg) Gastric ulcer was induced by applying a cryoprobe to the serosal surface of the stomach. Healing was assessed by determining the ulcer size at three and six days. Mucosal regenerative activity at the ulcer edge was assessed by quantitating DNA synthesis in cells by immunohistochemical techniques using monoclonal antibodies to detect expression of proliferating cell nuclear antigen (PCNA) and incorporated 5-bromo-5-iododeoxyuridine (BrdU). Compared with control rats, the rate of healing and the mucosal regenerative activity were significantly reduced in rats treated with prednisolone and indomethacin (p < 0.05). Coadministration of misoprostol and corticosteroids reversed the delay in healing and the reduction in mucosal regeneration induced by corticosteroids alone. With misoprostol alone, the ulcer size and the number of epithelial cells that actively synthesised DNA did not differ from control animals. A comparison between the two immunohistochemical markers of cell proliferation showed a highly significant correlation between the two techniques (r = 0.64, p < 0.005), indicating that the simpler PCNA technique should prove valuable in assessing regeneration in experimental ulcer disease.

Carpani de Kaski, M; Rentsch, R; Levi, S; Hodgson, H J

1995-01-01

314

Regenerative Effects of Transplanted Mesenchymal Stem Cells in Fracture Healing  

PubMed Central

Mesenchymal stem cells (MSC) have a therapeutic potential in patients with fractures to reduce the time of healing and treat non-unions. The use of MSC to treat fractures is attractive as it would be implementing a reparative process that should be in place but occurs to be defective or protracted and MSC effects would be needed only for the repairing time that is relatively brief. However, an integrated approach to define the multiple regenerative contributions of MSC to the fracture repair process is necessary before clinical trials are initiated. In this study, using a stabilized tibia fracture mouse model, we determined the dynamic migration of transplanted MSC to the fracture site, their contributions to the repair process initiation and their role in modulating the injury-related inflammatory responses. Using MSC expressing luciferase, we determined by bioluminescence imaging that the MSC migration at the fracture site is time- and dose-dependent and, it is exclusively CXCR4-dependent. MSC improved the fracture healing affecting the callus biomechanical properties and such improvement correlated with an increase in cartilage and bone content, and changes in callus morphology as determined by micro-computed-tomography and histological studies. Transplanting CMV-Cre-R26R-LacZ-MSC, we found that MSC engrafted within the callus endosteal niche. Using MSC from BMP-2-Lac-Z mice genetically modified using a bacterial artificial chromosome system to be ?-gal reporters for BMP-2 expression, we found that MSC contributed to the callus initiation by expressing BMP-2. The knowledge of the multiple MSC regenerative abilities in fracture healing will allow to design novel MSC-based therapies to treat fractures.

Granero-Molto, Froilan; Weis, Jared A.; Miga, Michael I.; Landis, Benjamin; Myers, Timothy J.; O'Rear, Lynda; Longobardi, Lara; Jansen, E. Duco; Mortlock, Douglas P.; Spagnoli, Anna

2012-01-01

315

Bromodeoxyuridine specifically labels the regenerative stem cells of planarians.  

PubMed

The singular regenerative abilities of planarians require a population of stem cells known as neoblasts. In response to wounding, or during the course of cell turnover, neoblasts are signaled to divide and/or differentiate, thereby replacing lost cell types. The study of these pluripotent stem cells and their role in planarian regeneration has been severely hampered by the reported inability of planarians to incorporate exogenous DNA precursors; thus, very little is known about the mechanisms that control proliferation and differentiation of this stem cell population within the planarian. Here we show that planarians are, in fact, capable of incorporating the thymidine analogue bromodeoxyuridine (BrdU), allowing neoblasts to be labeled specifically during the S phase of the cell cycle. We have used BrdU labeling to study the distribution of neoblasts in the intact animal, as well as to directly demonstrate the migration and differentiation of neoblasts. We have examined the proposal that a subset of neoblasts is arrested in the G2 phase of the cell cycle by double-labeling with BrdU and a mitosis-specific marker; we find that the median length of G2 (approximately 6 h) is sufficient to account for the initial mitotic burst observed after feeding or amputation. Continuous BrdU-labeling experiments also suggest that there is not a large, slow-cycling population of neoblasts in the intact animal. The ability to label specifically the regenerative stem cells, combined with the recently described use of double-stranded RNA to inhibit gene expression in the planarian, should serve to reignite interest in the flatworm as an experimental model for studying the problems of metazoan regeneration and the control of stem cell proliferation. PMID:10753506

Newmark, P A; Sánchez Alvarado, A

2000-04-15

316

Particle assemblies: toward new tools for regenerative medicine.  

PubMed

Regenerative medicine is a demanding field in terms of design and elaboration of materials able to meet the specifications that this application imposes. The regeneration of tissue is a multiscale issue, from the signaling molecule through cell expansion and finally tissue growth requiring a large variety of cues that should be delivered in place and time. Hence, the materials should be able to accommodate cells with respect to their phenotypes, to allow cell division to the right tissue, to maintain the integrity of the surrounding sane tissue, and eventually use their signaling machinery to serve the development of the appropriate neo-tissue. They should also present the ability to deliver growth factors and regulate tissue development, to be degraded into safe products, in order not to impede tissue development, and finally be easily implanted/injected into the patients. In this context, colloid-based materials represent a very promising family of products because one can take advantage of their high specific area, their capability to carry/deliver bio-active molecules, and their capacity of assembling (eventually in vivo) into materials featuring other mechanical, rheological, physicochemical properties. Other benefits of great interest would be their ease of production even via high through-put processes and their potential manufacturing from safe, biodegradable and biocompatible parent raw material. This review describes the state-of-the-art of processes leading to complex materials from the assembly of colloids meeting, at least partially, the above-described specifications for tissue engineering and regenerative medicine. PMID:23827536

Roux, R; Ladavière, C; Montembault, A; Delair, T

2012-12-11

317

Mesenchymal stem cell and regenerative medicine: regeneration versus immunomodulatory challenges  

PubMed Central

Mesenchymal Stem cells (MSC) are now presented with the opportunities of multifunctional therapeutic approaches. Several reports are in support of their self-renewal, capacity for multipotent differentiation, and immunomodulatory properties. They are unique to contribute to the regeneration of mesenchymal tissues such as bone, cartilage, muscle, ligament, tendon, and adipose. In addition to promising trials in regenerative medicine, such as in the treatment of major bone defects and myocardial infarction, MSC has shown a therapeutic effect other than direct hematopoiesis support in hematopoietic reconstruction. MSCs are identified by the expression of many molecules including CD105 (SH2) and CD73(SH3/4) and are negative for the hematopoietic markers CD34, CD45, and CD14. Manufacturing of MSC for clinical trials is also an important aspect as their differentiation, homing and Immunomodulatory properties may differ. Their suppressive effects on immune cells, including T cells, B cells, NK cells and DC cells, suggest MSCs as a novel therapy for GVHD and other autoimmune disorders. Since the cells by themselves are non-immunogenic, tissue matching between MSC donor and recipient is not essential and, MSC may be the first cell type able to be used as an “off-the-shelf” therapeutic product. Following a successful transplantation, the migration of MSC to the site of injury refers to the involvement of chemokines and chemokine receptors of respective specificity. It has been demonstrated that cultured MSCs have the ability to engraft into healthy as well as injured tissue and can differentiate into several cell types in vivo, which facilitates MSC to be an ideal tool for regenerative therapy in different disease types. However, some observations have raised questions about the limitations for proper use of MSC considering some critical factors that warn regular clinical use.

Law, Sujata; Chaudhuri, Samaresh

2013-01-01

318

Performance analysis of reciprocating regenerative magnetic heat pumping. Final report  

SciTech Connect

Transient flow phenomena in the regenerator tube of reciprocating magnetic heat pumps have been studied numerically and experimentally. In the numerical study, two approaches were taken: (1) solving the energy balance equations for fluid through a porous bed directly and (2) solving the Navier-Stokes equations with a buoyancy force term in the momentum equation. A flow thermal mixing problem was found in both approaches because of the piston-like motion of the regenerator tube that hinders the development of the temperature. The numerical study results show that a 45 K temperature span can be reached in 10 minutes of charge time through the use of a 7-Tesla magnetic field. Using the second numerical approach, temperature stratification in the regenerator fluid column was clearly indicated through temperature rasters. The study also calculates regenerator efficiency and energy delivery rates when heating load and cooling load are applied. Piecewise variation of the regenerator tube moving speed has been used in the present numerical study to control the mass flow rate, reduce thermal mixing of the flow and thus the regenerative losses. The gadolinium`s adiabatic temperature has been measured under 6.5 Tesla of magnet field and different of operating temperatures ranging from 285 K to 320 K. Three regenerative heat pumping tests have also been conducted based on the Reynolds number of the regenerator tube flow, namely Re=300, Re=450, and Re=750 without loads. Maximum temperature span are 12 & 11 K and 9 K for the case of Re=300, Re=450 and Re=750, respectively. Experimental data are in good agreement with the numerical calculation results, and have been used to calibrate the numerical results and to develop a design database for reciprocating-type room-temperature magnetic heat pumps.

Chen, D.T. [Oak Ridge Associated Universities, Inc., TN (United States); Murphy, R.W.; Mei, V.C.; Chen, F.C.; Lue, J.W.; Lubell, M.S. [Oak Ridge National Lab., TN (United States)

1994-02-01

319

Pituitary hyperplasia: a complication of the pseudomalabsorption of thyroxine  

PubMed Central

Objective “The pseudomalabsorption of thyroxine” has been used to describe patients with hypothyroidism who fail to comply with their treatment. We describe a unique case of a 32-year-old with hypothyroidism who developed pituitary hyperplasia and hyperprolactinemia secondary to the pseudomalabsorption of thyroxine. Investigations and treatment After baseline thyroid-function tests were performed, the patient was administered levothyroxine 0.5 mg under the supervision of a registered nurse. Thyroid function testing was repeated at 30, 60, 120, and 180 minutes. Arrangements were made for further daily supervised loading of levothyroxine 0.1 mg. Results With the administration of 0.5 mg levothyroxine, free thyroxine levels increased by 120 minutes, and with daily supervised dosing of 0.1 mg there was normalization of the thyroid hormone levels and a reduction of thyroid-stimulating hormone levels. Maintenance of thyroid-stimulating hormone < 15 mU/L for 2 weeks led to a reduction in prolactin levels and regression in the size of the pituitary on magnetic resonance imaging. Conclusion If left untreated, these patients face significant morbidity and are at risk of developing pituitary hyperplasia, complications from an increase in pituitary size, hyperprolactinemia, and potentially myxedema coma. Recognizing pituitary hyperplasia and hyperprolactinemia as a complication from the pseudomalabsorption of levothyroxine may prevent the potential of a misdiagnosis of a prolactinoma leading to unnecessary investigations and inappropriate treatment. Patient awareness of this serious complication and the rapid, demonstrable resolution with adequate thyroid hormone replacement may provide motivation to comply with supervised dosing of levothyroxine. It has also been suggested that supervised treatment enables the individual to maintain their patient status, which may be in part the motivation behind this disorder.

Doyle, Mary-Anne; Lochnan, Heather A

2013-01-01

320

The coexistence of atypical intraductal hyperplasias with breast carcinoma.  

PubMed

We present a study made during 4 years (1992-1996), which pursued the underlining of the atypical intraductal hiperplasias (A.I.D.H.) lesions, met isolated or in the association with mamar carcinoma. Our study included a 188 number of the breast tumors, among: in the 23 cases we established the existence of the modification by the A.I.D.H, type at the fibrocystics disease associated or not with the other benign diseases of the breast (fibroadenosis, intraductal papiloma) and in the 63 cases there were the modification by the AIDH associated with in situ or invasiv carcinoma. Epithelial hyperplasia is frequently associated with the fibrocystic changes, being included in the category of fibrocystic or proliferating modifications. The synonymous terms used for the epithelial hyperplasia are the hiperplazia ductala, or the epitelioza, or the papilomatosis The last two are suggested by the proliferation possibility (papillary or linear) of the epithelial or the mio-epithelial cells. Regardless of the microscopic aspect of the lesion, that should be acknowledged and treated as it is, due to the increased risk of the development of a carcinoma later on, and also due to the ratio of association between the modification and the mammary carcinoma. The risk of occurrence of subsequent carcinoma is augmented in the presence of the epithelial atipii and also increases in the presence of a mammary carcinoma at the relatives of the first rank (1.3). In this context, the importance of the differential diagnosis between the simple intraductal hyperplasia and the atypical one, the difficulty of differentiation from intraductal carcinoma in some cases, and finally the association with an increased risk of subsequent occurrence of carcinoma, constitute into sufficient arguments to consider this topic separately. PMID:15678845

Bogdan, F; Gîrni??, L; Florescu, M; Simionescu, C; Cr?i?oiu, S; Com?nescu, V

321

FACS analysis of the planarian stem cell compartment as a tool to understand regenerative mechanisms.  

PubMed

Planarians provide a relatively simple model system in which to study stem cell dynamics and regenerative phenomena. As with other systems understanding the dynamics of stem cell and stem cell progeny is crucial in order to get at the molecular mechanisms orchestrating stem cell biology. Planarians have an abundant adult stem cell population that can be observed using Fluorescence-Activated Cell Sorting (FACS). This approach allows different subpopulations of stem cells and their progeny to be monitored and sorted for downstream studies in response to different regenerative scenarios, drug treatments, or RNAi knockdown of genes required for regenerative events. PMID:22914940

Romero, Belen Tejada; Evans, Deborah J; Aboobaker, A Aziz

2012-01-01

322

Scaffold characterization using NLO multimodal microscopy in metrology for regenerative medicine  

NASA Astrophysics Data System (ADS)

Metrology in regenerative medicine aims to develop traceable measurement technologies for characterizing cellular and macromolecule behaviour in regenerative medicine products and processes. One key component in regenerative medicine is using three-dimensional porous scaffolds to guide cells during the regeneration process. The regeneration of specific tissues guided by tissue analogous substrates is dependent on diverse scaffold architectural properties that can be derived quantitatively from scaffolds images. This paper discuss the results obtained with the multimodal NLO microscope recently realized in our laboratory in characterizing 3D tissue engineered (TE) scaffolds colonized from human Mesenchimal stem cells (hMSC), focusing on the study of the three-dimensional metrological parameters.

Mortati, Leonardo; Divieto, Carla; Boffitto, Monica; Sartori, Susanna; Ciardelli, Gianluca; Sassi, Maria Paola

2013-09-01

323

Unilateral coronoid hyperplasia treated by coronoidectomy using a transzygomatic approach  

PubMed Central

Coronoid hyperplasia is a rare disorder, which effectively is a mechanical problem associated with limited mouth opening. In some cases, enlarged coronoid pushes the zygoma forward causing facial asymmetry. This article looks at the case of a 15-year-old boy reporting in OPD of Government College of Dentistry, Indore, with chief complaint of facial asymmetry. Transzygomatic approach was taken to get proper access to the enlarged coronoid. Coronoidectomy was performed which significantly reduced facial asymmetry. Postoperative healing was uneventful and recurrence was not reported.

Newaskar, Vilas; Idrees, Faisal; Patel, Poornima

2012-01-01

324

Which laser works best for benign prostatic hyperplasia?  

PubMed

The advantages offered by lasers compared to older technologies for endoscopic surgery for symptomatic benign prostate hyperplasia (BPH) are reviewed. Laser treatments for the endoscopic management of patients with bladder outlet obstruction (BOO) resulting from BPH can be divided into three basic techniques. These techniques are vaporisation (removal of tissue), resection of tissue (excision of small chips and subsequent irrigation from bladder) and enucleation (dissection of the adenoma from the surgical capsule and subsequent morcellation). The decision to offer a transurethral laser approach to patients with BPH depends on their comorbidities, the surgeon's expertise with the different procedures, and the availability of the relevant technology. PMID:23780301

Kahokehr, Arman Adam; Gilling, Peter J

2013-12-01

325

Review: transurethral microwave thermotherapy in benign prostatic hyperplasia.  

PubMed

The transurethral microwave thermotherapy (TUMT) method combines the principles of microwave radiative heating and conductive cooling to destroy tissue within the prostate while preserving the other structures of the lower urinary tract. The method is effective in benign prostatic hyperplasia (BPH), as demonstrated by laboratory and clinical studies. The ease of the 1-hour office treatment, the dramatic symptomatic improvement and reasonable uroflow rates that result, the preservation of sexual function, the apparent safety, and the durability of the result may mean that TUMT will introduce changes in the management of BPH as dramatic as those brought about in lithiasis management by ESWL. PMID:7689386

Devonec, M; Tomera, K; Perrin, P

1993-06-01

326

Recurrent conjunctival dermoid cyst with reactive lymphoid hyperplasia.  

PubMed

Conjunctival dermoid cysts are a rare subtype of dermoid cyst usually presenting in adulthood. The authors report a case of a recurrent conjunctival dermoid cyst with reactive lymphoid hyperplasia that was immunohistochemically demonstrated to be polyclonal. Follicular centers that were present within the cyst wall were negative for Bcl-2 and positive for the immunohistochemical markers CD20, Bcl-6, CD10, and Ki67, which helped to differentiate the lesion from a follicular lymphoma. The lesion did not recur after 14 months of follow-up. PMID:20562661

Stacy, Rebecca C; Jakobiec, Frederick A; Sutula, Francis C

327

[Operative treatment of benign prostate hyperplasia: modern aspects].  

PubMed

A retrospective analysis was made of the treatment results for the last 5 years of 879 patients with benign prostatic hyperplasia (BPH), 214 (24.3%) of whom had undergone transvesical adenomectomy while 665 (75.7%) had undergone transurethral resection (TUR) of the prostate. Adenomectomy had rather high effectiveness but was less safe than endoscopic intervention (higher lethality, more frequent development of myocardial infarction, pulmonary artery thromboembolism, postoperative hemorrhage). Patients operated for BPH are at risk of postoperative urethral stricture and sclerosis of urinary bladder cervix. Prebladder and postoperative stress urine incontinence appear only after open operations in BPH. PMID:15022441

Kamalov, A A; Gushchin, B L; Dorofeev, S D; Komlev, D L; Tokarev, F V; Efremov, E A

328

Segment-specific association between cervical pillar hyperplasia (CPH) and degenerative joint disease (DJD)  

Microsoft Academic Search

BACKGROUND: Cervical pillar hyperplasia (CPH) is a recently described phenomenon of unknown etiology and clinical significance. Global assessment of pillar hyperplasia of the cervical spine as a unit has not shown a relationship with degenerative joint disease, but a more sensible explanation of the architectural influence of CPH on cervical spine biomechanics may be segment-specific. OBJECTIVE: The objective of this

Maja Stupar; Cynthia K Peterson

2006-01-01

329

Bartter's syndrome with hyperplasia of renomedullary cells: Successful treatment with indomethacin  

Microsoft Academic Search

Bartter's syndrome with hyperplasia of renomedullary cells: Successful treatment with indomethacin. During treatment with indomethacin in a patient with Bartter's syndrome, hypokalemia, high plasma renin concentration, hyperaldosteronism and decreased sensitivity to angiotensin infusion were corrected. A particular finding in the renal biopsy specimen was a marked hyperplasia of renomedullary interstitial cells which had characteristics similar to the cells known to

René Verberckmoes; Boudewijn van Damme; Jan Clement; Antoon Amery; Paul Michielsen

1976-01-01

330

QUALITATIVE ANALYSIS OF SERUM PROTEINS IN BENIGN PROSTATIC HYPERPLASIA SEPARATED BY SDS-PAGE  

Microsoft Academic Search

This study was conducted for qualitative analysis of serum proteins separated by SDS-PAGE and stained by Coomassie Brilliant Blue R-250 in order to describe the preliminary identification of serum proteins that may act as diagnostic marker in benign prostatic hyperplasia. Serum samples of 23 biopsy confirmed cases of benign prostatic hyperplasia and normal controls of similar age group were subjected

Saima Naz; Sarah Ahmad; Farkhanda Ghafoor

2009-01-01

331

Effect of dutasteride on the detection of prostate cancer in men with benign prostatic hyperplasia  

Microsoft Academic Search

ObjectivesTo examine the rate of prostate cancer detection in three large randomized placebo-controlled benign prostatic hyperplasia trials of dutasteride. Dutasteride, which lowers serum dihydrotestosterone more than 93% by inhibiting type 1 and type 2 5-alpha-reductase, is effective in the treatment of benign prostatic hyperplasia. However, its effect on the development of prostate cancer is unknown.

G. L. Andriole; C. Roehrborn; C. Schulman; K. M. Slawin; M. Somerville; R. S. Rittmaster

2004-01-01

332

Two Closely Related but Distinct Retroviruses Are Associated with Walleye Discrete Epidermal Hyperplasia  

Microsoft Academic Search

Walleye discrete epidermal hyperplasia (WEH) is a hyperproliferative skin disease that is prevalent on adult walleye fish throughout North America. We have identified two retroviruses associated with WEH, designated here as walleye epidermal hyperplasia virus type 1 and type 2 (WEHV1 and WEHV2), that are closely related to one another (77% identity) and to walleye dermal sarcoma virus (64% identity)

LORIE A. LAPIERRE; DONALD L. HOLZSCHU; GREG A. WOOSTER; PAUL R. BOWSER; JAMES W. CASEY

1998-01-01

333

Adrenal Hypoplasia Congenita Presenting as Congenital Adrenal Hyperplasia  

PubMed Central

We report on a patient with genetically confirmed adrenal hypoplasia congenita (AHC) whose presentation and laboratory abnormalities were consistent with the more common condition, congenital adrenal hyperplasia (CAH). The patient presented with failure to thrive and salt wasting. General appearance showed marked hyperpigmentation and normal male genitalia. He displayed mildly elevated 17-hydroxyprogesterone and markedly elevated 11-deoxycortisol levels at baseline and with ACTH stimulation testing. Results were consistent with 11?-hydroxylase deficiency. He required glucocorticoids and high doses of mineralocorticoids. The marked elevation in 11-deoxycortisol directed our clinical reasoning away from a hypoplastic condition and towards a hyperplasic adrenal condition. Sequencing of the DAX1 gene (named for dosage-sensitive sex reversal (DSS) locus and the AHC locus on the X chromosome) revealed a missense mutation. A review of the literature revealed that elevated 11-deoxycortisol levels have been noted in kindreds with DAX1 mutations, but only when measured very early in life. A mouse model has recently been described that displays elevated 11-deoxycorticosterone levels and evidence for hyperplasia of the zona glomerulosa of the adrenal gland. We conclude that DAX1 testing may be considered in patients with laboratory evidence of 11?-hydroxylase deficiency, especially in those with severe salt wasting.

Flint, Jennifer L.; Jacobson, Jill D.

2013-01-01

334

An insidious risk factor for cardiovascular disease: benign prostatic hyperplasia.  

PubMed

Patients with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTSs) have a considerably higher prevalence of cardiovascular disease (CVD) than the general population in old age. Many hypotheses have been created to explain traditional clinical risk factors of CVD, including age, male gender, cigarette smoking, inheritance, high blood pressure (BP), obesity, elevated fasting plasma glucose, diabetes mellitus, dyslipidemia, decreased physical activity and metabolic syndrome; or nontraditional risk factors such as oxidative stress, inflammation, vascular calcification, malnutrition, homocysteine and genetic variation. Although these risk factors are important in CVD pathophysiology and clinical presentation, there is still no single theory sufficient to provide an adequate explanation for all the properties of CVD. We speculate that by causing nocturia-induced sleep disturbances, BP variability, increased sympathetic activity, non-dipping BP variations; BPH may be an insidious risk factor for CVD. Benign prostate hyperplasia may be related to increased BP, coronary ischemic hearth disease or other cardiovascular pathologic conditions. This attention on BPH may produce a new approach to the diagnosis and treatment of CVD. Although the underlying mechanisms are still exactly unclear, further prospective randomized controlled studies are needed to identify if patients with BPH/LUTS is higher risk for CVD. PMID:19359054

Karatas, Omer Faruk; Bayrak, Omer; Cimentepe, Ersin; Unal, Dogan

2009-04-09

335

New advances in benign prostatic hyperplasia: laser therapy.  

PubMed

Throughout the past decade, numerous techniques for the treatment of benign prostatic hyperplasia have emerged. Laser therapy, in particular, has gained widespread popularity among urologists. Since its inception in 1996, holmium laser enucleation of the prostate (HoLEP) has been evaluated rigorously in the treatment of glands of all sizes. HoLEP has produced superior relief of bladder outlet obstruction as compared to transurethral resection of the prostate based on urodynamics, and has proved equally as effective as open prostatectomy, for the management of very large glands (>100 cc), with lower morbidity. In addition to HoLEP, several newer but less well-studied laser techniques currently are available. These include photoselective laser vaporization utilizing the potassium-titanyl-phosphate (KTP or "green light") laser, thulium laser enucleation, and high-power diode laser vaporization. This report reviews the most current literature on laser therapies utilized in the treatment of benign prostatic hyperplasia with regards to safety, outcome, efficiency, and long-term durability. PMID:21088938

Mandeville, Jessica; Gnessin, Ehud; Lingeman, James E

2011-02-01

336

Altered catecholamine receptor affinity in rabbit aortic intimal hyperplasia  

SciTech Connect

Intimal thickening is a universal response to endothelial denudation and is also thought to be a precursor of atherosclerosis. The authors have demonstrated selective supersensitivity in arterial intimal hyperplasia to norepinephrine and they now report a possible mechanism for this. Binding studies in rabbit aorta with the selective alpha 1-adrenergic radioligand 125I-HEAT demonstrated that there was no change in receptor density (20 {plus minus} 4 fmole/10(6) cells) in intact vascular smooth muscle cells at either 5 or 14 days after denudation. However, competition studies showed a 2.6-fold increase in alpha 1-adrenergic receptor affinity for norepinephrine in intimal hyperplastic tissue (P less than 0.05). This increased affinity for norepinephrine was associated with a greater increase in 32P-labeled phosphatidylinositol (148% intimal thickening versus 76% control) and phosphatidic acid (151% intimal thickening versus 56% control) following norepinephrine stimulation of free floating rings of intimal hyperplastic aorta. These data suggest that the catecholamine supersensitivity in rabbit aortic intimal hyperplasia is receptor mediated and may be linked to the phosphatidylinositol cycle.

O'Malley, M.K.; Cotecchia, S.; Hagen, P.O. (Duke University Medical Center, Durham, NC (USA))

1991-08-01

337

Adrenal hypoplasia congenita presenting as congenital adrenal hyperplasia.  

PubMed

We report on a patient with genetically confirmed adrenal hypoplasia congenita (AHC) whose presentation and laboratory abnormalities were consistent with the more common condition, congenital adrenal hyperplasia (CAH). The patient presented with failure to thrive and salt wasting. General appearance showed marked hyperpigmentation and normal male genitalia. He displayed mildly elevated 17-hydroxyprogesterone and markedly elevated 11-deoxycortisol levels at baseline and with ACTH stimulation testing. Results were consistent with 11 ? -hydroxylase deficiency. He required glucocorticoids and high doses of mineralocorticoids. The marked elevation in 11-deoxycortisol directed our clinical reasoning away from a hypoplastic condition and towards a hyperplasic adrenal condition. Sequencing of the DAX1 gene (named for dosage-sensitive sex reversal (DSS) locus and the AHC locus on the X chromosome) revealed a missense mutation. A review of the literature revealed that elevated 11-deoxycortisol levels have been noted in kindreds with DAX1 mutations, but only when measured very early in life. A mouse model has recently been described that displays elevated 11-deoxycorticosterone levels and evidence for hyperplasia of the zona glomerulosa of the adrenal gland. We conclude that DAX1 testing may be considered in patients with laboratory evidence of 11 ? -hydroxylase deficiency, especially in those with severe salt wasting. PMID:23476826

Flint, Jennifer L; Jacobson, Jill D

2013-02-12

338

PAR2 modulates PAR1-driven neointimal hyperplasia  

PubMed Central

Objective Emerging evidence suggests that protease-activated receptors-1 and 2 (PAR1 and PAR2) can signal together in response to proteases found in the rapidly changing microenvironment of damaged blood vessels. However, it is unknown whether PAR1 and PAR2 promote or mitigate the hyperplastic response to arterial injury. Using cell-penetrating PAR1 pepducins and mice-deficient in PAR1 or PAR2, we set out to determine the respective contributions of the receptors to hyperplasia and phenotypic modulation of smooth muscle cells (SMCs) in response to arterial injury. Methods and Results SMCs were strongly activated by PAR1 stimulation as evidenced by increased mitogenesis, mitochondrial activity, and calcium mobilization. The effects of chronic PAR1 stimulation following vascular injury were studied by performing carotid artery ligations in mice treated with PAR1 agonist pepducin, P1pal-13. Histological analysis revealed that PAR1 stimulation caused striking hyperplasia which was ablated in PAR1-/-, and surprisingly in PAR2-/- mice. P1pal-13 treatment yielded an expression pattern consistent with a de-differentiated phenotype in carotid artery SMCs. Detection of PAR1-PAR2 complexes provided an explanation for the hyperplastic effects of the PAR1 agonist requiring the presence of both receptors. Conclusions We conclude that PAR2 regulates the PAR1 hyperplastic response to arterial injury leading to stenosis.

Sevigny, Leila M.; Austin, Karyn M.; Zhang, Ping; Kasuda, Shogo; Koukos, Georgios; Sharifi, Sheida; Covic, Lidija; Kuliopulos, Athan

2011-01-01

339

Melanocyte Changes in Epidermal Hyperplasia--An Experimental Study  

PubMed Central

Subepidermal injection of suspensions of silica in guinea-pigs produces granulomatous inflammation in the dermis and hyperplasia of the overlying epidermis. In the experiments described here this procedure was adopted in 16 animals in order to investigate the behaviour of the melanocytes in the hyperplastic epidermis. The DOPA reaction was used to identify melanocytes and the number of DOPA positive cells per 100 basal epidermal cells (DOPA index) was correlated with the degree of epidermal hyperplasia. The epidermal reaction was charted by estimating the autoradiographic labelling index after injection of tritiated thymidine and measuring the epidermal thickness. The DOPA index fell in the hyperplastic epidermis and had not returned to control levels by three weeks. However, there were foci within the epidermis where the number of melanocytes and their reactivity appeared to be increased. The number of “clear cells” in the basal epidermis was also estimated and the numbers of these cells approximately paralleled the changes in the DOPA positive cells. Silver staining for melanin did not demonstrate pigmentary incontinence. ImagesFigs. 2-4

Eady, R.; Marks, R.

1973-01-01

340

Apolipoprotein E Inhibits Neointimal Hyperplasia after Arterial Injury in Mice  

PubMed Central

The potential cytostatic function of apolipoprotein (apo) E in vivo was explored by measuring neointimal hyperplasia in response to vascular injury in apoE-deficient and apoE-overexpressing transgenic mice. Results showed a significant increase in medial thickness, medial area, and neointimal formation after vascular injury in both apoE knockout and wild-type C57BL/6 mice. Immunochemical analysis with smooth muscle ?-actin-specific antibodies revealed that the neointima contained proliferating smooth muscle cells. Neointimal area was 3.4-fold greater, and the intima/medial ratio as well as stenotic luminal area was more pronounced in apoE(?/?) mice than those observed in control mice (P < 0.05). The human apoE3 transgenic mice in FVB/N genetic background were then used to verify a direct effect of apoE in protection against neointimal hyperplasia in response to mechanically induced vascular injury. Results showed that neointimal area was reduced threefold to fourfold in mice overexpressing the human apoE3 transgene (P < 0.05). Importantly, suppression of neointimal formation in the apoE transgenic mice also abolished the luminal stenosis observed in their nontransgenic FVB/N counterparts. These results documented a direct role of apoE in modulating vascular response to injury, suggesting that increasing apoE level may be beneficial in protection against restenosis after vascular surgery.

Zhu, Binghua; Kuhel, David G.; Witte, David P.; Hui, David Y.

2000-01-01

341

Effect of Phellius linteus water extract on benign prostatic hyperplasia.  

PubMed

Benign prostatic hyperplasia (BPH) is one of the most common diseases among elderly men. As the old-age population is increasing recently, it is to our interest to observe the growing BPH within them. In BPH, the dihydrotestosterone (DHT) acts as promotes prostate growth. It inhibits enzyme 5?-reductase that is involved in the conversion of testosterone to the DHT activity which reduces the excessive prostate growth. Through experiments, the effects of Phellius linteus water extract performed on the BPH rats were induced by testosterone treatments. For 12 weeks, Sprague-Dawley rats were treated with testosterone for the induction of BPH. Rats were divided into four experimental groups: the not treated group (N), the testosterone injection and D.W treatment group (TN), the testosterone injection and Phellinus linteus treatment group (TP) and testosterone injection and finasteride treatment group (TF). Prostate weight, volume and weight ratio in the TP group and the TF group were significantly lower than the TN group. Testosterone and DHT levels in the TN group were significantly higher than that of the N group. And the TP group was significantly decreased than that of the TN group. While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation; the TP and TF groups showed trophic symptoms and were lined by flattened epithelial cells, thus, the stromal proliferation is relatively low as compared to the TN group. These suggest that Phellinus linteus water extracts may be an useful remedy for treating the benign prostatic hyperplasia. PMID:23766877

Kim, Yu-Na; Kim, Min-Sun; Chun, Sung-Sik; Choi, Jeong-Hwa

2013-06-03

342

Regenerative fuel cells for High Altitude Long Endurance Solar Powered Aircraft.  

National Technical Information Service (NTIS)

High Altitude Long Endurance (HALE) unmanned missions appear to be feasible using a lightweight, high efficiency, span-loaded, Solar Powered Aircraft (SPA) which includes a Regenerative Fuel Cell (RFC) system and novel tankage for energy storage. An exist...

F. Mitlitsky N. J. Colella B. Myers C. J. Anderson

1993-01-01

343

Multichannel all-optical 3R regenerative wavelength conversion using an integrated semiconductor optical amplifier array  

Microsoft Academic Search

Multichannel all-optical 3R regenerative wavelength conversion at 10 Gbit\\/s is demonstrated using a novel module in a fibre interferometer. The module is a packaged, monolithically integrated, 22-channel SOA-array with 2 AWG routers.

G. Gavioli; P. Bayvel

2003-01-01

344

Transforming Regenerative Medicine: An Interdisciplinary Approach. Final Report. May 19-20, 2008.  

National Technical Information Service (NTIS)

A Workshop on Transforming Regenerative Medicine: An Interdisciplinary Approach was held on May 1920, 2008, in Bethesda, Maryland, by the National Institutes of Health. The primary objective of this critical workshop was to bring together leaders in the m...

2008-01-01

345

Generation of ultrashort radiation pulses by injection locking a regenerative free-electron-laser amplifier  

NASA Astrophysics Data System (ADS)

We demonstrate how a steady-state train of ultrashort radiation pulses can be produced utilizing a new free-electron laser (FEL) configuration, the injection-locked regenerative klystron amplifier (IRKA). This configuration consists of two elements: (1) a prebuncher, which microbunches the electron beams at the desired output wavelength, and (2) a multipass FEL operated at a very small cavity desynchronism and below the lasing threshold, in the regime of regenerative amplification. The regenerative amplifier is driven by the microbunched electron beam, so that the pulse-to-pulse stability is provided by the pre-buncher. The broad amplification bandwidth of this regenerative amplifier enables generation of ultrashort pulses, much shorter than a slippage length, with high efficiency. The IRKA configuration can produce such ultra-short radiation pulses while avoiding the chaotic dynamics that limits conventional FEL performance.

Shvets, G.; Wurtele, J. S.

1997-09-01

346

The Regenerative Potential of the Mammalian Spinal Cord and Peripheral Nervous System.  

National Technical Information Service (NTIS)

During this program, an improved method for neurorrhapy has been developed. It has also been shown that certain brachial plexus injuries can be rectified through surgery. The dorsal spinal nerve root and spinal cord both show a regenerative potential but,...

J. B. Campbell

1970-01-01

347

Unitized regenerative fuel cells for solar rechargeable aircraft and zero emission vehicles.  

National Technical Information Service (NTIS)

A unitized regenerative fuel cell (URFC) produces power and electrolytically regenerates its reactants using a single stack of reversible cells. URFCs have been designed for high altitude long endurance (HALE) solar rechargeable aircraft (SRA), zero emiss...

F. Mitlitsky N. J. Colella B. Myers

1994-01-01

348

Analysis of a regenerative braking system for Hybrid Electric Vehicles using an ElectroMechanical Brake  

Microsoft Academic Search

The regenerative braking system of the Hybrid Electric Vehicle (HEV) is a key technology that can improve fuel efficiency\\u000a by 20?50%, depending on motor size. In the regenerative braking system, the electronically controlled brake subsystem that\\u000a directs the braking forces into four wheels independently is indispensable. This technology is currently found in the Electronic\\u000a Stability Program (ESP) and in Vehicle

J. K. Ahn; K. H. Jung; D. H. Kim; H. B. Jin; H. S. Kim; S. H. Hwang

2009-01-01

349

Simulation and Performance Evaluation of Hydraulic Transmission Electromagnetic Energy-Regenerative Active Suspension  

Microsoft Academic Search

A new shock absorber with the combined mechanical-electromagnetic-hydraulic structure is proposed to recycle the energy dissipated by shock absorber in the process of driving. The suspension system built on the new shock absorber is generally called hydraulic transmission electromagnetic energy-regenerative suspension. This paper presents the working theories of the hydraulic transmission electromagnetic energy-regenerative suspension, and also builds a kinetics simulation

Xu Lin; Yang Bo; Guo Xuexun; Yan Jun

2010-01-01

350

Regenerative braking control strategy in mild hybrid electric vehicles equipped with automatic manual transmission  

Microsoft Academic Search

The actual regenerative braking force of an integrated starter\\/generator (ISG), which is varied with desired braking deceleration\\u000a and vehicle speed, is calculated based on an analysis of the required deceleration, maximum braking force of ISG, engine braking\\u000a force and state of charge (SOC) of battery. Braking force distribution strategies are presented according to the actual regenerative\\u000a braking force of ISG.

Datong Qin; Ming Ye; Zhenjun Liu

2007-01-01

351

An automatic pulse alignment method for slope controlled super-regenerative receiver systems  

Microsoft Academic Search

Recently there is an increase in interest for using super-regenerative receivers for pulse based communication systems. To receive a pulse using the super-regenerative architecture the pulse needs to be aligned with the zero crossing of the damping co-efficient (which depends on the quench signal) for achieving maximum sensitivity. In general, the pulse to be received is not aligned with the

P. E. Thoppay; C. Dehollain; M. J. Declercq

2007-01-01

352

Two-color chirped-pulse amplification in an ultrabroadband Ti:sapphire ring regenerative amplifier  

Microsoft Academic Search

We have developed a high-energy, ultrabroadband Ti:sapphire ring regenerative amplifier capable of producing in excess of 20-mJ output at a 10-Hz repetition rate. The technique of chirped-pulse amplification is used to generate two-color, time-synchronized pulses with central wavelength separations of up to ~120 nm and with a total energy of 10 mJ by use of a regenerative pulse-shaping technique. Mid-infrared

Koichi Yamakawa; C. P. J. Barty

2003-01-01

353

Comparative studies on plant range size: Linking reproductive and regenerative traits in two Ipomoea species  

Microsoft Academic Search

Reproductive and regenerative traits associated with colonization and persistence ability may determine plant range size. However, few comparative studies on plant distribution have assessed these traits simultaneously. Pollinator richness and frequency of visits, autonomous self-pollination ability, reproductive output (i.e., reproductive traits), seed bank strategy and seedling density (i.e., regenerative traits) were compared between the narrowly distributed Ipomoea rubriflora O’Donnell (Convolvulaceae)

Julia Astegiano; Guillermo Funes; Leonardo Galetto

2010-01-01

354

Modeling and optimization of a regenerative fuel cell system using the ASPEN process simulator  

Microsoft Academic Search

The Hydrogen-Oxygen Regenerative Fuel Cell System was identified as a key component for energy storage in support of future lunar missions. Since the H2-O2 regenerative electrochemical conversion technology has not yet been tested in space applications, it is necessary to implement predictive techniques to develop initial feasible system designs. The ASPEN simulation software furnishes a constructive medium for analyzing and

Thomas M. Maloney; Harold F. Leibecki

1990-01-01

355

Regenerative medicine approach to repair the failing heart.  

PubMed

Heart failure is a serious and very common clinical condition in which the heart is about to stop working. Currently, heart failure has no cure. Over the last decade, cardiac cell therapy has been widely studied as a revolutionary approach to promote the non-pharmacological replacement of the lost myocardium. Despite the initial enormous expectations, recent clinical trials have shown modest results without therapeutic effectiveness following cardiac stem cell transplantation. Since the adult heart is not a post-mitotic organ, recent disappointing findings have motivated researchers to pursue alternative therapeutic approaches. New scientific developments on myocardial regeneration derived from studies in animal models have led to the discovery of new naturally occurring molecules that increase the resistance of resident cardiac cells to the ischemic microenvironment and/or promote the self-renewing property of adult myocardium without the transplantation of additional stem cells. Recent evidences have shown that the direct intramyocardial injection of selected chemical compounds in adult beating heart may halt myocardial remodeling and increase cardiac performance in an epigenetic manner. The aim of the present review is to discuss succinctly some important aspects of the new frontiers of regenerative therapy to repair the failing heart. PMID:23337493

Lionetti, Vincenzo; Ventura, Carlo

2013-01-19

356

Polymer-based microparticles in tissue engineering and regenerative medicine.  

PubMed

Different types of biomaterials, processed into different shapes, have been proposed as temporary support for cells in tissue engineering (TE) strategies. The manufacturing methods used in the production of particles in drug delivery strategies have been adapted for the development of microparticles in the fields of TE and regenerative medicine (RM). Microparticles have been applied as building blocks and matrices for the delivery of soluble factors, aiming for the construction of TE scaffolds, either by fusion giving rise to porous scaffolds or as injectable systems for in situ scaffold formation, avoiding complicated surgery procedures. More recently, organ printing strategies have been developed by the fusion of hydrogel particles with encapsulated cells, aiming the production of organs in in vitro conditions. Mesoscale self-assembly of hydrogel microblocks and the use of leachable particles in three-dimensional (3D) layer-by-layer (LbL) techniques have been suggested as well in recent works. Along with innovative applications, new perspectives are open for the use of these versatile structures, and different directions can still be followed to use all the potential that such systems can bring. This review focuses on polymeric microparticle processing techniques and overviews several examples and general concepts related to the use of these systems in TE and RE applications. The use of materials in the development of microparticles from research to clinical applications is also discussed. PMID:21584949

Oliveira, Mariana B; Mano, João F

2011-05-16

357

Comparison of endometrial regenerative cells and bone marrow stromal cells  

PubMed Central

Background Endometrial regenerative cells (ERC) and bone marrow stromal cells (BMSC) are being used in clinical trials. While they have been reported to have similar characteristics, they have not been directly compared. Methods We compared micro RNA (miRNA) and gene expression profiles, soluble cytokine and growth factor levels and ability to inhibit ongoing mixed leukocyte reaction (MLR) of ERC and BMSC each derived from 6 healthy subjects. Results ERC and BMSC miRNA and gene expression profiles were similar, but not identical; more differences were noted in the expression of genes than in miRNAs. Genes overexpressed in ERCs were more likely to be in immune and inflammation pathways and those overexpressed in BMSCs were more likely to be in stem cell and cancer signaling pathways. In addition, the levels of IL-8 and ICAM-1 were greater in ERC supernatants while the levels of HGF, VEGF, IL-6, CXCL12, TGFB1 and TGFB2 were greater in BMSC supernatants. Additionally, ERC demonstrated greater inhibition of the proliferation of mixed leukocyte cultures. Conclusions These results suggest that the in vivo effects of ERC and BMSC may differ. Multiple properties of stromal cells are responsible for their in vivo effectiveness and ERC may be more effective for some of the clinical applications and BMSC for others. Studies in animal models or clinical trials will be required to more fully characterize the differences between ERC and BMSC.

2012-01-01

358

Tissue engineering and regenerative medicine: history, progress, and challenges.  

PubMed

The past three decades have seen the emergence of an endeavor called tissue engineering and regenerative medicine in which scientists, engineers, and physicians apply tools from a variety of fields to construct biological substitutes that can mimic tissues for diagnostic and research purposes and can replace (or help regenerate) diseased and injured tissues. A significant portion of this effort has been translated to actual therapies, especially in the areas of skin replacement and, to a lesser extent, cartilage repair. A good amount of thoughtful work has also yielded prototypes of other tissue substitutes such as nerve conduits, blood vessels, liver, and even heart. Forward movement to clinical product, however, has been slow. Another offshoot of these efforts has been the incorporation of some new exciting technologies (e.g., microfabrication, 3D printing) that may enable future breakthroughs. In this review we highlight the modest beginnings of the field and then describe three application examples that are in various stages of development, ranging from relatively mature (skin) to ongoing proof-of-concept (cartilage) to early stage (liver). We then discuss some of the major issues that limit the development of complex tissues, some of which are fundamentals-based, whereas others stem from the needs of the end users. PMID:22432625

Berthiaume, François; Maguire, Timothy J; Yarmush, Martin L

2011-01-01

359

Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Biology  

NASA Astrophysics Data System (ADS)

The potential of human embryonic stem cells (ESCs) for regenerative medicine is unquestionable, but practical and ethical considerations have hampered clinical application and research. In an attempt to overcome these issues, the conversion of somatic cells into pluripotent stem cells similar to ESCs, commonly termed nuclear reprogramming, has been a top objective of contemporary biology. More than 40 years ago, King, Briggs, and Gurdon pioneered somatic cell nuclear reprogramming in frogs, and in 1981 Evans successfully isolated mouse ESCs. In 1997 Wilmut and collaborators produced the first cloned mammal using nuclear transfer, and then Thomson obtained human ESCs from in vitro fertilized blastocysts in 1998. Over the last 2 decades we have also seen remarkable findings regarding how ESC behavior is controlled, the importance of which should not be underestimated. This knowledge allowed the laboratory of Shinya Yamanaka to overcome brilliantly conceptual and technical barriers in 2006 and generate induced pluripotent stem cells (iPSCs) from mouse fibroblasts by overexpressing defined combinations of ESC-enriched transcription factors. Here, we discuss some important implications of human iPSCs for biology and medicine and also point to possible future directions.

Pei, Duanqing; Xu, Jianyong; Zhuang, Qiang; Tse, Hung-Fat; Esteban, Miguel A.

360

Carbon nanotubes: directions and perspectives in oral regenerative medicine.  

PubMed

One of the main goals of bone tissue engineering is to identify and develop new biomaterials and scaffolds for structural support and controlled cell growth, which allow for formation or replacement of bone tissue. Recently, carbon nanotubes (CNT) have emerged as a potential candidate for bone tissue engineering. CNT present remarkable mechanical, thermal, and electrical properties with easy functionalization capability and biocompatibility. In oral regenerative medicine, bone reconstruction is an essential requirement for functional rehabilitation of the stomatognathic system. Autologous bone still represents the gold standard graft material for bone reconstruction. However, the small amounts of bone available in donor regions, together with the high costs of surgeries, are critical aspects that hinder the selection of this procedure. Thus, CNT alone or combined with biopolymers have promise to be used as novel potential biomaterials for the restoration of bone defects. Indeed, recent evidence demonstrates CNT to be a feasible material that can increase the formation of bone in tooth sockets of rats. The purpose of this review is to summarize the recent developments in bone repair/regeneration with CNT or CNT-based composites. We further provide an overview of bone tissue engineering and current applications of biomaterials, especially of CNT, to enhance bone regeneration. PMID:23677650

Martins-Júnior, P A; Alcântara, C E; Resende, R R; Ferreira, A J

2013-05-15

361

Regenerative flywheel storage system. Volume II. Final report  

SciTech Connect

This report describes the development, fabrication, and test of a regenerative flywheel energy storage and recovery system for a battery/flywheel electric vehicle of the 3000-lb class. The vehicle propulsion system was simulated on a digital computer in order to determine the optimum system operating strategies and to establish a calculated range improvement over a nonregenerative, all-electric vehicle. Fabrication of the inductor motor, the flywheel, the power conditioner, and the system control are described. Test results of the system operating over the SAE J227a Schedule D driving cycle are given and are compared to the calculated value. The flywheel energy storage system consists of a solid rotor, synchronous, inductor-type, flywheel drive machine electrically coupled to a d-c battery electric propulsion system through a load-commutated inverter. The motor/alternator unit is coupled mechanically to a small steel flywheel which provides a portion of the vehicle's accelerating energy and regenerates the vehicle's braking energy. Laboratory simulation of the electric vehicle propulsion system includes a 108-volt, lead-acid battery bank and a separately excited d-c propulsion motor coupled to a flywheel and generator which simulate the vehicle's inertia and losses. This volume reports the theoretical and experimental studies which were performed and the results of these studies.

Not Available

1980-06-27

362

Regenerative flywheel energy storage system. Volume I. Executive summary  

SciTech Connect

This report describes the development, fabrication, and test of a regenerative flywheel energy storage and recovery system for a battery/flywheel electric vehicle of the 3000-pound class. The vehicle propulsion system was simulated on a digital computer in order to determine the optimum system operating strategies and to establish a calculated range improvement over a nonregenerative, all-electric vehicle. Fabrication of the inductor motor, the flywheel, the power conditioner, and the system control are described. Test results of the system operating over the SAE J227a Schedule D driving cycle are given and are compared to the calculated value. The flywheel energy storage system consists of a solid rotor, synchronous, inductor-type, flywheel drive machine electrically coupled to a d-c battery electric propulsion system through a load-commutated inverter. The motor/alternator unit is coupled mechanically to a small steel flywheel which provides a portion of the vehicle's accelerating energy and regenerates the vehicle's braking energy. Laboratory simulation of the electric vehicle propulsion system includes a 108-volt, lead-acid battery bank and a separately excited d-c propulsion motor coupled to a flywheel and generator which simulate the vehicle's inertia and losses. This volume summarizes information on the scope of the program, vehicle system studies, the flywheel system design, vehicle power conditioner and control, and test results. (LCL)

Not Available

1980-06-27

363

Testing a Regenerative Carbon Dioxide and Moisture Removal Technology  

NASA Astrophysics Data System (ADS)

The National Aeronautics and Space Administration supported the development of a new vacuum-desorbed regenerative carbon dioxide and humidity control technology for use in short duration human spacecraft. The technology was baselined for use in the Orion Crew Exploration Vehicle's Environmental Control and Life Support System (ECLSS). Termed the Carbon Diox-ide And Moisture Removal Amine Swing-bed (CAMRAS), the unit was developed by Hamilton Sundstrand and has undergone extensive testing at Johnson Space Center. The tests were per-formed to evaluate performance characteristics under range of operating conditions and human loads expected in future spacecraft applications, as part of maturation to increase its readiness for flight. Early tests, conducted at nominal atmospheric pressure, used human metabolic sim-ulators to generate loads, with later tests making us of human test subjects. During these tests many different test cases were performed, involving from 1 to 6 test subjects, with different activity profiles (sleep, nominal and exercise). These tests were conducted within the airlock portion of a human rated test chamber sized to simulate the Orion cabin free air volume. More recently, a test was completed that integrated the CAMRAS with a simulated suit loop using prototype umbilicals and was conducted at reduced atmospheric pressure and elevated oxygen levels. This paper will describe the facilities and procedures used to conduct these and future tests, and provide a summary of findings.

Barta, Daniel J.; Button, Amy; Sweterlitsch, Jeffrey; Curley, Suzanne

364

Is a regenerative approach viable for the treatment of COPD?  

PubMed Central

Degenerative lung diseases such as chronic obstructive pulmonary disease (COPD) are common with huge worldwide morbidity. Anti-inflammatory drug development strategies have proved disappointing and current treatment is aimed at symptomatic relief. Only lung transplantation with all its attendant difficulties offers hope of cure and the outlook for affected patients is bleak. Lung regeneration therapies aim to reverse the structural and functional deficits in COPD either by delivery of exogenous lung cells to replace lost tissue, delivery of exogenous stem cells to induce a local paracrine effect probably through an anti-inflammatory action or by the administration of small molecules to stimulate the endogenous regenerative ability of lung cells. In animal models of emphysema and disrupted alveolar development each of these strategies has shown some success but there are potential tumour-inducing dangers with a cellular approach. Small molecules such as all-trans retinoic acid have been successful in animal models although the mechanism is not completely understood. There are currently two Pharma-sponsored trials in progress concerning patients with COPD, one of a specific retinoic acid receptor gamma agonist and another using mesenchymal stem cells. LINKED ARTICLES This article is part of a themed issue on Respiratory Pharmacology. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2011.163.issue-1

Hind, Matthew; Maden, Malcolm

2011-01-01

365

Melamine: a regenerative SO/sub 2/ absorbent  

SciTech Connect

A new regenerative SO/sub 2/ abatement process using melamine has been developed. In this process a gas stream containing SO/sub 2/ is contacted with an aqueous slurry of melamine to produce solid melamine sulfite. The solids are separated and thermally decomposed at 100/sup 0/-200/sup 0/C. Statistically designed laboratory scrubbing tests using simulated stack gas were performed at 50/sup 0/C to determine the relative effects of slurry concentration, SO/sub 2/ concentration, CO/sub 2/, O/sub 2/, NO, fly ash, antioxidant, and prescrubber on the melamine scrubbing process. Average SO/sub 2/ removal for these tests with 2000 and 4000 ppm SO/sub 2/ was 95.5%, and each mole of melamine absorbed 0.5 mole of SO/sub 2/. Carbon dioxide (12%) and NO (600 ppm) did not reduce the scrubbing efficiency or capacity of the melamine, and the addition of an antioxidant (0.1% paraphenylenediamine) effectively minimized oxidation. The melamine scrubbing process looks promising and offers the advantages of high SO/sub 2/ removal and low energy requirement regeneration.

Gautney, J.; Kim, Y.K.; Hatfield, J.D.

1982-03-01

366

Thermal Inkjet Printing in Tissue Engineering and Regenerative Medicine  

PubMed Central

With the advantages of high throughput, digital control, and highly accurate placement of cells and biomaterial scaffold to the desired 2D and 3D locations, bioprinting has great potential to develop promising approaches in translational medicine and organ replacement. The most recent advances in organ and tissue bioprinting based on the thermal inkjet printing technology are described in this review. Bioprinting has no or little side effect to the printed mammalian cells and it can conveniently combine with gene transfection or drug delivery to the ejected living systems during the precise placement for tissue construction. With layer-by-layer assembly, 3D tissues with complex structures can be printed using scanned CT or MRI images. Vascular or nerve systems can be enabled simultaneously during the organ construction with digital control. Therefore, bioprinting is the only solution to solve this critical issue in thick and complex tissues fabrication with vascular system. Collectively, bioprinting based on thermal inkjet has great potential and broad applications in tissue engineering and regenerative medicine. This review article introduces some important patents related to bioprinting living systems and the bioprinting in tissue engineering field.

Cui, Xiaofeng; Boland, Thomas; D'Lima, Darryl D.; Lotz, Martin K.

2013-01-01

367

A report of the ASPS Task Force on regenerative medicine: opportunities for plastic surgery.  

PubMed

In 2011, the American Society of Plastic Surgeons (ASPS) created the Task Force on Regenerative Medicine to address the Society's strong interest in the emerging field of regenerative medicine, particularly cell- and tissue-based therapies applicable to plastic surgery procedures. The Task Force's U.S. Food and Drug Administration's Workgroup is informing ASPS interactions with the U.S. Food and Drug Administration's Center for Biologics Evaluation and Research. Engaging in dialogue with the agency to determine which research protocols will produce scientific data necessary to determine safety and efficacy for regenerative cellular therapies can allow research to be targeted to gather data that prove safety and efficacy of specific categories of therapies and/or products. This article reviews the regulatory backdrop of regenerative medicine, briefly reviews the history of regenerative medicine, and then looks at current research and potential future areas of research and clinical application. The historic ability of plastic surgeons to innovate and apply translational research positions the specialty of plastic surgery as a strong leader in clinical applications of regenerative medicine therapies. PMID:23358001

D'Amico, Richard A; Rubin, J Peter; Neumeister, Michael W; Del Vecchio, Daniel A; Cederna, Paul S; Seward, William; Shoaf, Lori

2013-02-01

368

Restoration of anterior regeneration in a planarian with limited regenerative ability.  

PubMed

Variability of regenerative potential among animals has long perplexed biologists. On the basis of their exceptional regenerative abilities, planarians have become important models for understanding the molecular basis of regeneration. However, planarian species with limited regenerative abilities are also found. Despite the importance of understanding the differences between closely related, regenerating and non-regenerating organisms, few studies have focused on the evolutionary loss of regeneration, and the molecular mechanisms leading to such regenerative loss remain obscure. Here we examine Procotyla fluviatilis, a planarian with restricted ability to replace missing tissues, using next-generation sequencing to define the gene expression programs active in regeneration-permissive and regeneration-deficient tissues. We found that Wnt signalling is aberrantly activated in regeneration-deficient tissues. Notably, downregulation of canonical Wnt signalling in regeneration-deficient regions restores regenerative abilities: blastemas form and new heads regenerate in tissues that normally never regenerate. This work reveals that manipulating a single signalling pathway can reverse the evolutionary loss of regenerative potential. PMID:23883929

Sikes, James M; Newmark, Phillip A

2013-07-24

369

A survey of attitude and opinions of endodontic residents towards regenerative endodontics  

PubMed Central

Aim: The objective of this survey was to study the level of awareness, current state of knowledge and opinions towards regenerative endodontic treatments amongst the endodontic residents of India. Settings and Design: Questionnaire based survey was designed. Materials and Methods: After approval from the organizing committee of 26th Federation of Operative Dentistry of India and 19th Indian Endodontic Society National conference 2011, 200 copies of the questionnaire were circulated amongst the endodontic residents in conservative dentistry and endodontics at various colleges across the country about regenerative endodontic procedures. The survey included profile of the respondents and consisted of 23 questions about their knowledge, attitude and opinions regarding use of these procedures as part of future dental treatment. Results: The survey showed that half the participants (50.6%) had received continued education in stem cells and/or regenerative dental treatments. The majority of participants were of the opinion (86.6%) that regenerative therapy should be incorporated into dentistry, and most of them (88%) were willing to acquire training in learning this new treatment strategy. The results indicated that half of the participants (52.6%) were already using some type of regenerative therapy in their clinical practice; however, with a majority of these limited to use of membranes, scaffolds or bioactive materials. Conclusions: These results reflect that endodontic residents are optimistic about the use of regenerative endodontic procedures; however, a need for more research and training was felt.

Utneja, Shivani; Nawal, Ruchika Roongta; Ansari, Mohammed Irfan; Talwar, Sangeeta; Verma, Mahesh

2013-01-01

370

Factors determining final height in congenital adrenal hyperplasia.  

PubMed

Congenital adrenal hyperplasia (CAH) is a family of adrenal disorders whereby cortisol biosynthesis is impaired or abolished. In most cases, CAH is caused by a deficiency of the enzyme 21-hydroxylase causing a massive build up of adrenal precursors. In addition to prenatal virilisation of genetic females and postnatal virilisation of both males and females, short adult stature is characteristic of the disorder. The inadequate final height in CAH patients is often attributed to overtreatment with glucocorticoid replacement and poor control of adrenal androgen levels. In a recent study, the use of growth hormone alone and in combination with gonadotropin releasing hormone analogue in children with CAH and poor predicted final height was found to decrease height deficit after one and two years of treatment. PMID:11529398

New, M I

2001-07-01

371

Lymphoid nodules and nodular lymphoid hyperplasia in bone marrow biopsies.  

PubMed

Out of 2,474 bone marrow biopsies we have observed 330 cases (13.3%) with presence of lymphoid nodules (LN). LN were frequent in old age (24.6% over 80 years), in females (17%) and in some diseases, such as rheumatoid arthritis and systemic lupus erythematosus (73.7% of the cases), partial aplasia (34%), hypersplenism (30.4%), hemopoietic dysplasia (25%), chronic renal failure (20.4%), polycythemia vera (20.2%), idiopathic thrombocytopenic purpura (18.8%), acute leukemia (17.7%). Nodular lymphoid hyperplasia of the bone marrow was found especially in systemic autoimmune diseases (26.3%), hypersplenism (9.8%), preleukemia (7.3%) and acute leukemia (4.2%). The presence of excessive medullary LN could indicate a bone marrow microenvironment damage, possibly of autoimmune origin. PMID:3934902

Navone, R; Valpreda, M; Pich, A

1985-01-01

372

Anorexia nervosa in a patient with congenital adrenal hyperplasia.  

PubMed

Life stressors and hormonal dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis are common factors that play a role in both anorexia nervosa (AN) and congenital adrenal hyperplasia (CAH). The complexity of combined CAH and AN on the HPA axis has not, to our knowledge, been previously illustrated. We present a report of an adolescent with CAH who developed AN, requiring hospitalized management. We use this case to review the pathophysiology of CAH and AN as it relates to the stress response and hormonal dysregulation within the HPA axis. We then highlight the interplay between these conditions, and provide support to the theory that AN acts as a chronic stressor in patients with CAH, leading to HPA axis hyperactivity and elevated levels of androgen precursors. It is prudent for the medical team to monitor and modify CAH steroid dosing during the acute phase of AN, weaning appropriately with AN treatment success. PMID:23382307

Galle, Jennifer; Kirsch, Susan; Kaufman, Miriam

2013-01-01

373

Diagnosis and management of classical congenital adrenal hyperplasia.  

PubMed

Congenital adrenal hyperplasia (CAH) is among the most common genetic disorders. Deficiency of adrenal steroid 21-hydroxylase deficiency due to mutations in the CYP21A2 gene accounts for about 95% cases of CAH. This disorder manifests with androgen excess with or without salt wasting. It also is a potentially life threatening disorder; neonatal screening with 17-hydroxyprogesterone measurement can diagnose the condition in asymptomatic children. Carefully monitored therapy with glucocorticoid and mineralocorticoid supplementation will ensure optimal growth and development for children with CAH. Genital surgery may be required for girls with CAH. Continued care is required for individuals with CAH as adults to prevent long-term adverse consequences of the disease, including infertility, metabolic syndrome and osteoporosis. PMID:23624029

Marumudi, Eunice; Khadgawat, Rajesh; Surana, Vineet; Shabir, Iram; Joseph, Angela; Ammini, Ariachery C

2013-04-25

374

Diagnosis and management of hepatic focal nodular hyperplasia  

PubMed Central

Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver, after hemangioma. It is generally found incidentally and is most common in reproductive-aged women, but it also affects males and can be diagnosed at any age. Patients are rarely symptomatic, but FNH sometimes causes epigastric or right upper quadrant pain. The main clinical task is to differentiate it from other hypervascular hepatic lesions such as hepatic adenoma, hepatocellular carcinoma, or hypervascular metastases, but invasive diagnostic procedures can generally be avoided with the appropriate use of imaging techniques. Magnetic resonance (MR) imaging is more sensitive and specific than conventional ultrasonography (US) or computed tomography (CT), but Doppler US and contrast-enhanced US (CEUS) can greatly improve the accuracy in the diagnosis of FNH. Once a correct diagnosis has been made, in most cases there is no indication for surgery, and treatment includes conservative clinical follow-up in asymptomatic patients.

Venturi, A.; Piscaglia, F.; Vidili, G.; Flori, S.; Righini, R.; Golfieri, R.; Bolondi, L.

2007-01-01

375

Does Pseudohypoaldosteronism Mask the Diagnosis of Congenital Adrenal Hyperplasia?  

PubMed Central

Hyponatremia and hyperpotassemia occurring in the first few weeks of life primarily indicate aldosterone deficiency due to salt-losing congenital adrenal hyperplasia (SL-CAH), while mineralocorticoid deficiency and insensitivity are the main causes of hyponatremia and hyperpotassemia in older infants. Some patients who present with vomiting and poor sucking, who have hyponatremia and hyperpotassemia and are initially diagnosed as CAH, during follow-up, are found to suffer from pseudohypoaldosteronism (PHA). This situation has been reported several times before. The cases described here represent the opposite situation: they presented with hyponatremia and hyperpotassemia, thus PHA was considered as aldosterone levels were very high, but subsequent investigation and genetic analysis led to the diagnosis of SL-CAH. Conflict of interest:None declared.

Aycan, Zehra; Peltek Kendirci, Havva Nur; Erkek, Nilgun; Bas, Veysel Nijat

2011-01-01

376

Papillary endothelial hyperplasia presenting as recurrent malignant glioma.  

PubMed

The initial management of patients with malignant gliomas depends on accurate histologic diagnosis which, in turn, directs appropriate treatment planning. However, the diagnosis of recurrent disease is often based solely on radiological data which can occasionally be misinterpreted as showing recurrent tumor. Lack of awareness of conditions that mimic recurrent tumor and potentially confound radiological diagnosis can lead to inappropriate therapeutic decisions. We report the case of a patient whose imaging studies suggested recurrence of malignant glioma; however, surgical resection of the lesion guided by MRI scans resulted in the correct diagnosis of papillary endothelial hyperplasia and led to appropriate management of this condition that mimicked tumor recurrence. In this report, we provide a comprehensive review of this rare entity and emphasize the importance of adequately pursuing appropriate diagnostic considerations prior to making definitive treatment decisions. PMID:20740304

Ong, Shirley S; Bruner, Janet; Schellingerhout, Dawid; Puduvalli, Vinay K

2010-08-26

377

Mandible condylar hyperplasia: a review of diagnosis and treatment protocol  

PubMed Central

Condylar hyperplasia (CH) is a bone disease characterized by the increased development of one mandibular condyle. It regularly presents as an active growth with facial asymmetry generally without pain. Statistically it affects more women in adolescence, although it does not discriminate by age or gender. Its best-known consequence is asymmetric facial deformity (AFD), which combined with alteration of the dental occlusion with unilateral crossbite or open bite. It is not known when CH begins and how long it lasts; diagnostic examinations are described and are efficient in some research about diagnosis. Protocol treatment is not well studie and depends on the criteria described in this paper. The aim of this research is to provide up-to-date information about the diagnosis of this disease and to analyze the treatment protocol, visualizing the CH and AFD presented.

Olate, Sergio; Netto, Henrique Duque; Rodriguez-Chessa, Jaime; Alister, Juan Pablo; de Albergaria-Barbosa, Jose; de Moraes, Marcio

2013-01-01

378

Hereditary gingival hyperplasia associated with amelogenesis imperfecta: a case report.  

PubMed

Hereditary gingival fibromatosis (HGF) and amelogenesis imperfecta (AI) are two rare oral conditions with genetic etiologies. The case of a 17-year-old boy affected by HGF, AI, anterior open bite, and pyramidal impaction of the maxillary molars is reported. Internal bevel gingivectomies were carried out to reduce gingival overgrowth. Clinical examination of the family revealed the presence of HGF and AI in his 12-year-old sister (both in milder forms) and of HGF in his older half brother. Genetic sequencing analyses were performed to detect any of the known mutations leading to HGF and AI. Histologic analysis revealed the presence of fibroepithelial hyperplasia, consistent with a diagnosis of GF. Sequencing genetic analysis failed to identify any of the common mutations leading to HGF (SOS-1) or AI (enamelin and amelogenin genes). This phenotype, similar to what has been described in other families, may represent a new syndrome caused by an as-yet unknown genotype. PMID:22532955

Nibali, Luigi; Brett, Peter M; Donos, Nikos; Griffiths, Gareth S

2012-06-01

379

Correlations in the cytokine system in endometrial hyperplasia.  

PubMed

Correlations between local expression of insulin-like growth factor 1, insulin-like growth factor receptor, epithelial growth factor, transforming growth beta2 factor, PCNA, TNF-alpha, TNF receptor 1, Fas, FasL, IFN-gamma, IL-1beta, IL-4, IL-6, IL-8, IL-10, and IL-12 genes in intact and hyperplastic endometrium and in the endometrium after hormone therapy were analyzed. Numerous correlations at the proliferation and secretion stages of the menstrual cycle indicate balanced cytokine system. The number of correlations decreases in glandular cystic and more so in atypical hyperplasia, indicating imbalance in the cytokine system. Dufastone and zoladex therapy did not lead to recovery of this balance, but higher correlations between the expression of some factors of cell proliferation attest to the beginning of normalization of pathologically changed endometrium. PMID:15098542

Zhdanov, A V; Sukhikh, G T; Davydova, M P; Slukina, T V; Chernukha, G E; Samoilova, T E; Smetnik, V P

2003-09-01

380

Silodosin in the treatment of benign prostatic hyperplasia.  

PubMed

Benign prostatic hyperplasia (BPH)-associated lower urinary tract symptoms (LUTS) are highly prevalent in older men. Medical therapy is the first-line treatment for LUTS due to BPH. Alpha-adrenergic receptor blockers remain one of the mainstays in the treatment of male LUTS and clinical BPH. They exhibit early onset of efficacy with regard to both symptoms and flow rate improvement, and this is clearly demonstrated in placebo-controlled trials with extensions out to five years. These agents have been shown to prevent symptomatic progression of the disease. The aim of this article is to offer a critical review of the current literature on silodosin, formerly known as KMD-3213, a novel alpha-blocker with unprecedented selectivity for ?(1A)-adrenergic receptors, as compared with both ?(1B)- and ?(1D) -adrenoceptors, exceeding the selectivity of all currently used ?(1)-blockers, and with clinically promising effects. PMID:21116335

Rossi, Maxime; Roumeguère, Thierry

2010-10-27

381

Silodosin in the treatment of benign prostatic hyperplasia  

PubMed Central

Benign prostatic hyperplasia (BPH)-associated lower urinary tract symptoms (LUTS) are highly prevalent in older men. Medical therapy is the first-line treatment for LUTS due to BPH. Alpha-adrenergic receptor blockers remain one of the mainstays in the treatment of male LUTS and clinical BPH. They exhibit early onset of efficacy with regard to both symptoms and flow rate improvement, and this is clearly demonstrated in placebo-controlled trials with extensions out to five years. These agents have been shown to prevent symptomatic progression of the disease. The aim of this article is to offer a critical review of the current literature on silodosin, formerly known as KMD-3213, a novel alpha-blocker with unprecedented selectivity for ?1A-adrenergic receptors, as compared with both ?1B- and ?1D -adrenoceptors, exceeding the selectivity of all currently used ?1-blockers, and with clinically promising effects.

Rossi, Maxime; Roumeguere, Thierry

2010-01-01

382

A Whole-Organ Regenerative Medicine Approach for Liver Replacement  

PubMed Central

Background & Aims The therapy of choice for end-stage liver disease is whole-organ liver transplantation, but this option is limited by a shortage of donor organs. Cell-based therapies and hepatic tissue engineering have been considered as alternatives to liver transplantation, but neither has proven effective to date. A regenerative medicine approach for liver replacement has recently been described that includes the use of a three-dimensional organ scaffold prepared by decellularization of xenogeneic liver. The present study investigates a new, minimally disruptive method for whole-organ liver decellularization and three different cell reseeding strategies to engineer functional liver tissue. Methods A combination of enzymatic, detergent, and mechanical methods are used to remove all cells from isolated rat livers. Whole-organ perfusion is used in a customized organ chamber and the decellularized livers are examined by morphologic, biochemical, and immunolabeling techniques for preservation of the native matrix architecture and composition. Three different methods for hepatocyte seeding of the resultant three-dimensional liver scaffolds are evaluated to maximize cell survival and function: (1) direct parenchymal injection, (2) multistep infusion, or (3) continuous perfusion. Results The decellularization process preserves the three-dimensional macrostructure, the ultrastructure, the composition of the extracellular matrix components, the native microvascular network of the liver, and the bile drainage system, and up to 50% of growth factor content. The three-dimensional liver matrix reseeded with the multistep infusion of hepatocytes generated ?90% of cell engraftment and supported liver-specific functional capacities of the engrafted cells, including albumin production, urea metabolism, and cytochrome P450 induction. Conclusions Whole-organ liver decellularization is possible with maintenance of structure and composition suitable to support functional hepatocytes.

Zhang, Li; Medberry, Chris; Fukumitsu, Ken; Faulk, Denver; Jiang, Hongbin; Reing, Janet; Gramignoli, Roberto; Komori, Junji; Ross, Mark; Nagaya, Masaki; Lagasse, Eric; Stolz, Donna; Strom, Stephen C.; Fox, Ira J.

2011-01-01

383

A regenerative multiple zone model for HCCI combustion  

SciTech Connect

A new conserved scalar approach, the so-called regenerative multiple zone (RMZ) model, is introduced to simulate combustion in homogeneous charge compression ignition (HCCI) engines with significant products of combustion. In this approach, two conserved scalars are introduced, the mixture fraction Z and the initial exhaust gas fraction J, to determine uniquely the state of the reactive system as a function of the two conserved scalars and time. For the numerical solution of the HCCI combustion, the conserved scalar plane is divided into different zones, which represent homogeneous reactors with constant initial exhaust gas level. Particularly, the zones are created based on the distribution of the initial exhaust gases and are mixed and regenerated at every time step during combustion in order to account for the history effects which are due to the finite rate chemistry. A proper methodology to create and initialize the new zones during the combustion, the so-called zone creation strategy (ZCS), is also proposed. For validation, the RMZ model is implemented in the 2DRD code, which is a computational fluid dynamics code that solves the governing equations for a two-dimensional reaction-diffusion problem. Initially, the consistency of the new model is validated in a one-dimensional reaction-diffusion (RD) case. Subsequently, the necessity for a proper zone creation strategy is demonstrated by a two-dimensional RD case. Next, a parametric study is performed to investigate the sensitivity of the new model on the maximum number of zones that is used. Finally, the limitations as well as the advantages of the RMZ model are discussed. (author)

Hamosfakidis, Vasileios; Im, Hong G.; Assanis, Dennis N. [Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109 (United States)

2009-04-15

384

Intestinal nodular lymphoid hyperplasia and extraintestinal lymphoma--a rare association.  

PubMed

Nodular lymphoid hyperplasia of the gastrointestinal tract is characterized by the presence of innumerable small discrete nodules involving a variable segment of the gastrointestinal tract. The association between nodular lymphoid hyperplasia and other benign and malignant diseases has been clearly described, with an increased risk of gastrointestinal tumours, namely gastrointestinal lymphoma. However, the association with extraintestinal lymphoma seems extremely rare. The authors present a clinical case of a patient with nodular lymphoid hyperplasia of the small and large intestine that subsequently developed an extraintestinal lymphoma (diffuse large B-cell lymphoma). PMID:22870792

Monsanto, P; Lérias, C; Almeida, N; Lopes, S; Cabral, J E; Figueiredo, P; Silva, M; Julião, M; Gouveia, H; Sofia, C

2012-06-01

385

Rebound thymic hyperplasia after pneumonectomy and chemotherapy for primary synovial sarcoma.  

PubMed

Thymic hyperplasia occurs in a small proportion of patients receiving chemotherapy for various malignancies. It likely results from an immunologic rebound phenomenon. Fluorodeoxyglucose positron emission tomography-computed tomography is an important tool for staging malignant neoplasms. We report a case of rebound thymic hyperplasia manifesting as a hypermetabolic mass on fluorodeoxyglucose positron emission tomography-computed tomography after pneumonectomy and chemotherapy for primary pulmonary synovial sarcoma. We highlight the importance of recognizing the phenomenon of rebound thymic hyperplasia, as it can mimic residual or recurrent malignancy, especially in the setting of altered chest anatomy. PMID:18728544

Ford, Meghan E; Stevens, Robert; Rosado-de-Christenson, Melissa L; Hall, Nathan C; Suster, Saul

2008-08-01

386

The nitroreductase system of inducible targeted ablation facilitates cell-specific regenerative studies in zebrafish.  

PubMed

At the turn of the 20th century, classical regenerative biology - the study of organismal/tissue/limb regeneration in animals such as crayfish, snails, and planaria - garnered much attention. However, scientific luminaries such as Thomas Hunt Morgan eventually turned to other fields after concluding that inquiries into regenerative mechanisms were largely intractable beyond observational intrigues. The field of regeneration has enjoyed a resurgence in research activity at the turn of the 21st century, in large part due to "the promise" of cultured stem cells regarding reparative therapeutic approaches. Additionally, genomics-based methods that allow sophisticated genetic/molecular manipulations to be carried out in nearly any species have extended organismal regenerative biology well beyond observational limits. Throughout its history, complex paradigms such as limb regeneration - involving multiple tissue/cell types, thus, potentially multiple stem cell subtypes - have predominated the regenerative biology field. Conversely, cellular regeneration - the replacement of specific cell types - has been studied from only a few perspectives (predominantly muscle and mechanosensory hair cells). Yet, many of the degenerative diseases that regenerative biology hopes to address involve the loss of individual cell types; thus, a primary emphasis of the embryonic/induced stem cell field is defining culture conditions which promote cell-specific differentiation. Here we will discuss recent methodological approaches that promote the study of cell-specific regeneration. Such paradigms can reveal how the differentiation of specific cell types and regenerative potential of discrete stem cell niches are regulated. In particular, we will focus on how the nitroreductase (NTR) system of inducible targeted cell ablation facilitates: (1) large-scale genetic and chemical screens for identifying factors that regulate regeneration and (2) in vivo time-lapse imaging experiments aimed at investigating regenerative processes more directly. Combining powerful screening and imaging technologies with targeted ablation systems can expand our understanding of how individual stem cell niches are regulated. The former approach promotes the development of therapies aimed at enhancing regenerative potentials in humans, the latter facilitates investigation of phenomena that are otherwise difficult to resolve, such as the role of cellular transdifferentiation or the innate immune system in regenerative paradigms. PMID:23542552

White, David T; Mumm, Jeff S

2013-03-27

387

Current insights on the regenerative potential of the periosteum: molecular, cellular, and endogenous engineering approaches.  

PubMed

While century old clinical reports document the periosteum's remarkable regenerative capacity, only in the past decade have scientists undertaken mechanistic investigations of its regenerative potential. At a Workshop at the 2012 Annual Meeting of Orthopaedic Research Society, we reviewed the molecular, cellular, and tissue scale approaches to elucidate the mechanisms underlying the periosteum's regenerative potential as well as translational therapies engineering solutions inspired by its remarkable regenerative capacity. The entire population of osteoblasts within periosteum, and at endosteal and trabecular bone surfaces within the bone marrow, derives from the embryonic perichondrium. Periosteal cells contribute more to cartilage and bone formation within the callus during fracture healing than do cells of the bone marrow or endosteum, which do not migrate out of the marrow compartment. Furthermore, a current healing paradigm regards the activation, expansion, and differentiation of periosteal stem/progenitor cells as an essential step in building a template for subsequent neovascularization, bone formation, and remodeling. The periosteum comprises a complex, composite structure, providing a niche for pluripotent cells and a repository for molecular factors that modulate cell behavior. The periosteum's advanced, "smart" material properties change depending on the mechanical, chemical, and biological state of the tissue. Understanding periosteum development, progenitor cell-driven initiation of periosteum's endogenous tissue building capacity, and the complex structure-function relationships of periosteum as an advanced material are important for harnessing and engineering ersatz materials to mimic the periosteum's remarkable regenerative capacity. PMID:22778049

Colnot, Céline; Zhang, Xinping; Knothe Tate, Melissa L

2012-07-09

388

Innate immune cells are dispensable for regenerative growth of imaginal discs.  

PubMed

Following tissue damage the immune response, including inflammation, has been considered an inevitable condition to build the host defense against invading pathogens. The recruitment of innate immune leukocytes to injured tissue is observed in both vertebrates and invertebrates. However, it is still not conclusive whether the inflammatory response is also indispensable for the wound healing process by itself, in addition to its role in microbial clearance. In this study we determine the requirement of innate immune cells, both hemocytes and fat body cells, in Drosophila imaginal disc regeneration. We investigate wound healing and regenerative cell proliferation of damaged imaginal discs under immunodeficient conditions. To delay development of Drosophila at matured third instar larval stage we used a sterol-mutant erg2 knock-out yeast strain in the medium. This dietary-controlled developmental arrest allowed us to generate larvae free of immune cells without interfering with their larval development. In addition, this approach allowed uncoupling regenerative cell proliferation of damaged discs from their normal developmental growth. We furthermore examined the regenerative cell proliferation of fragmented imaginal discs by transplantation into host flies deficient of immune cells. We demonstrate that the damaged/fragmented discs in immune cells deficient conditions still exhibit regenerative cell proliferation comparable to those of control samples. These results suggest that recruitment of immune cells is not a prerequisite for the regenerative growth of damaged imaginal discs. PMID:23238120

Katsuyama, Tomonori; Paro, Renato

2012-12-10

389

Performance characteristics of a regenerative catalytic oxidizer for treating VOC-contaminated airstreams.  

PubMed

A pilot apparatus of a regenerative catalytic oxidizer (RCO) equipped with two electrical heaters and two 20-cm i.d. x 200-cm height regenerative beds was used to treat methyl ethyl ketone (MEK) and toluene, respectively, in an airstream. The regenerative beds were packed with gravel (approximate particle size 1.25 cm, specific area 205 m2/m3, and specific heat capacity 840 J/kg degree C) as a solid regenerative material and K-type thermal couples for measuring solid and gas temperatures, respectively. The catalyst bed temperature was kept around 400 degrees C and the gas superficial velocity was operated at 0.234 m/sec. This investigation measured and analyzed distributions of solid and gas temperatures with operating time and variations of volatile organic compound (VOC) concentrations in the regenerative beds. The overall VOC removal efficiency exceeded 98% for MEK and 95% for toluene. Degradation of VOCs will exist for MEK on the surface of solid material (gravel) in the temperature range of 330-400 degrees C, but toluene does not exhibit this phenomenon. PMID:11140140

Chou, M S; Cheng, W H; Lee, W S

2000-12-01

390

Stem cells and regenerative medicine: principles, prospects and problems.  

PubMed

Stem cells have been used routinely for more than three decades to repair tissues and organs damaged by injury or disease, most notably haematopoietic stem cells taken from bone marrow, umbilical cord or, increasingly, from peripheral blood. Other examples, such as grafts of skin to treat severe burns, entail transplantation of stem cells within organized tissue rather than following isolation. The prospect of exploiting stem cells more widely in regenerative medicine was encouraged both by the development of human assisted conception and growing evidence that various adult cells retained greater versatility than had been suspected hitherto. The aim is to employ stem cells as a source of appropriately differentiated cells to replace those lost through physical, chemical or ischaemic injury, or as a result of degenerative disease. This may entail transplantation of just a single type of cell or, more challengingly, require a complex of several different types of cells possessing a defined architecture. Cardiomyocytes, hepatocytes or neuronal cells producing specific transmitters offer promising examples of the former, although how transplanted healthy cells will function in a perturbed tissue environment remains to be established. Recent success in repairing urinary bladder defects with grafts of urothelial and muscle cells seeded on a biodegradable collagen scaffold is an encouraging step towards assembling organs in vitro. Nevertheless, this is still far removed from the level of sophistication required to counter the ever increasing shortfall in supply of kidneys for transplantation. Various problems must be addressed if recent advances in the laboratory are to be translated into clinical practice. In many cases, it has yet to be established that cells derived from adults that retain plasticity are actually stem cells. There is also a pressing need for appropriate assays to ensure that, regardless of source, stem cells maintained in vitro are safe to transplant. Assays currently available for human ES cells are far from ideal. It is, in addition, important to ensure that differentiated cultures are pure and, depending on whether cell renewal is required or to be avoided, retain or lack appropriate stem cells. Neither autografts nor those obtained by so-called 'therapeutic cloning' are options for treating condition with an obvious genetic basis. Moreover, claims that some stem cells are more likely than others to yield successful allografts have yet to be confirmed and explained. PMID:17631439

Gardner, Richard L

2007-02-15

391

Malignant mesothelioma eight years after a diagnosis of atypical mesothelial hyperplasia.  

PubMed

The separation of mesothelial hyperplasia from early malignant mesothelioma remains one of the most difficult problems in histopathology. Inconclusive cases are termed "atypical mesothelial hyperplasia" and treated expectantly. A 49 year old male pipeline engineer was diagnosed as having atypical mesothelial hyperplasia in appendiceal serosa by the US-Canadian Mesothelioma Panel. Eight years later, he developed overtly malignant peritoneal and pleural mesothelioma. In hindsight, histological similarities between the diffuse malignant mesothelioma and the atypical mesothelial proliferation suggested malignancy from the outset. The most important of these features were the degree of mesothelial proliferation, micronodularity, architectural complexity, superficial invasion, uniform mild cytological atypia, and the absence of a clinical cause for a benign mesothelial proliferation. Ancillary investigations including immunohistochemistry were of no benefit in determining whether the atypical mesothelial hyperplasia was benign or malignant. Careful histological examination remains the mainstay of the diagnosis of early mesothelioma. PMID:10605410

Scurry, J; Duggan, M A

1999-07-01

392

Malignant mesothelioma eight years after a diagnosis of atypical mesothelial hyperplasia.  

PubMed Central

The separation of mesothelial hyperplasia from early malignant mesothelioma remains one of the most difficult problems in histopathology. Inconclusive cases are termed "atypical mesothelial hyperplasia" and treated expectantly. A 49 year old male pipeline engineer was diagnosed as having atypical mesothelial hyperplasia in appendiceal serosa by the US-Canadian Mesothelioma Panel. Eight years later, he developed overtly malignant peritoneal and pleural mesothelioma. In hindsight, histological similarities between the diffuse malignant mesothelioma and the atypical mesothelial proliferation suggested malignancy from the outset. The most important of these features were the degree of mesothelial proliferation, micronodularity, architectural complexity, superficial invasion, uniform mild cytological atypia, and the absence of a clinical cause for a benign mesothelial proliferation. Ancillary investigations including immunohistochemistry were of no benefit in determining whether the atypical mesothelial hyperplasia was benign or malignant. Careful histological examination remains the mainstay of the diagnosis of early mesothelioma. Images

Scurry, J; Duggan, M A

1999-01-01

393

Unknown syndrome: microcephaly, hypoplastic nose, exophthalmos, gum hyperplasia, cleft palate, low set ears, and osteosclerosis  

Microsoft Academic Search

We report a neonate, born at term, with microcephaly, a hypoplastic nose, exophthalmos, gum hyperplasia, cleft palate, and low set ears, who died at 86 minutes of age. Radiographs showed diffuse sclerosis of the bones.

J Raine; R M Winter; A Davey; S M Tucker

1989-01-01

394

Gastric hyperplasia and parietal cell loss in Taenia taeniaeformis inoculated immunodeficient mice  

Microsoft Academic Search

Immunodeficient mice were studied to determine their suitability as models in investigating the role of Taenia taeniaeformis larval products in the development of gastric hyperplasia. Recombinant active gene 2 (RAG2)-deficient and severe combined immune-deficient (SCID) mice were studied as candidate animal models. RAG2-deficient mice inoculated orally with T. taeniaeformis eggs developed gastric hyperplasia with alcian blue-periodic acid-Schiff-positive cell proliferation similar

Jose Trinipil Lagapa; Kenjiro Konno; Yuzaburo Oku; Nariaki Nonaka; Mamoru Ito; Masao Kamiya

2002-01-01

395

Overexpression of G Protein-Coupled Receptor Kinase2 in Smooth Muscle Cells Reduces Neointimal Hyperplasia  

Microsoft Academic Search

K. Peppel, L. Zhang, T. T. T. Huynh, X. Huang, A. Jacobson, L. Brian, S. T. Exum, P.-O. Hagen and N. J. Freedman. Overexpression of G Protein-Coupled Receptor Kinase-2 in Smooth Muscle Cells Reduces Neointimal Hyperplasia. Journal of Molecular Cellular Cardiology (2002) 34, 1399–1409. The activation of vascular smooth muscle cells (SMCs) in neointimal hyperplasia involves signaling through receptor tyrosine

Karsten Peppel; Lisheng Zhang; Tam T. T. Huynh; Xuewei Huang; Anne Jacobson; Leigh Brian; Sabrina T. Exum; Per-Otto Hagen; Neil J. Freedman

2002-01-01

396

Complex Hyperplasia With and Without Atypia: Clinical Outcomes and Implications of Progestin Therapy  

PubMed Central

Objective Limited data exist to inform clinicians and patients as to the likelihood of long-term endometrial hyperplasia response to progestin therapy, especially for atypical hyperplasia. We evaluated women with complex and atypical endometrial hyperplasia, comparing those prescribed progestin to those not prescribed progestin. Methods This retrospective cohort study was conducted in 1985–2005 among women aged 18–88 years at an integrated health plan in Washington State. Women were ineligible if they achieved an outcome (endometrial carcinoma, hysterectomy, or both) within 8 weeks of hyperplasia diagnosis. Exposure was progestin use for at least 14 days, by duration and recency. Outcomes included rate of: 1) endometrial carcinoma; and/or 2) hysterectomy. Analyses performed included Kaplan Meier, incident rate ratios, and Cox proportional hazard ratios. Results One thousand four hundred forty-three eligible women were identified. One thousand two hundred one had complex (n=164 no progestin) and 242 had atypical hyperplasia (n=62 no progestin). During follow-up, median 5.3 years (range 8 weeks to 20.8 years), 71 women were diagnosed with endometrial carcinoma (35 complex, 36 atypia) and 323 underwent hysterectomy (216 complex, 107 atypia). Among women with complex and atypical hyperplasia, rates of endometrial carcinoma among progestin users were 3.6 and 20.5 per 1,000 woman-years, respectively (compared with without progestin, 10.8 and 101.4). Among women with complex and atypical hyperplasia, rates of hysterectomy among progestin users were 23.3 and 61.4 per 1,000 woman-years, respectively (compared with without progestin, 55.1 and 297.3). Conclusion Endometrial carcinoma risk is diminished approximately 3- to 5-fold in women diagnosed with complex or atypical endometrial hyperplasia and dispensed progestin; hysterectomy risk is also decreased.

Reed, Susan D; Newton, Katherine M; Garcia, Rochelle L; Allison, Kimberly H; Voigt, Lynda F; Jordan, C Diana; Epplein, Meira; Swisher, Elizabeth; Upson, Kristen; Ehrlich, Kelly J; Weiss, Noel S

2010-01-01

397

Focal nodular hyperplasia of the liver: a rational approach to treatment.  

PubMed Central

Focal nodular hyperplasia of the liver in a 3 year old child has been successfully treated by ligation of the hepatic artery branches supplying the lesion. The prominence of the abnormal vasculature in the lesion and its possible aetiological involvement is stressed. Because of the risks of partial hepatectomy, hepatic artery ligation is suggested as the treatment of choice for focal nodular hyperplasia. Images Fig. 1 Fig. 2

Mowat, A P; Gutjahr, P; Portmann, B; Dawson, J L; Williams, R

1976-01-01

398

Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism  

Microsoft Academic Search

Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism.BackgroundSecondary hyperparathyroidism (HPT) in chronic kidney disease (CKD) is a physiologic response to kidney failure characterized by elevated serum parathyroid hormone (PTH) levels and parathyroid gland enlargement. Calcimimetic agents acting through allosteric modification of the calcium-sensing receptor (CaR) can attenuate parathyroid hyperplasia in rats with secondary HPT. The present

MATTHEW COLLOTON; EDWARD SHATZEN; GERALD MILLER; CATHERINE STEHMAN-BREEN; MICHIHITO WADA; DAVID LACEY; DAVID MARTIN

2005-01-01

399

Calcimimetic NPS R-568 prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism  

Microsoft Academic Search

Calcimimetic NPS R-568 prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism.BackgroundSecondary hyperparathyroidism (secondary HPT) in chronic renal insufficiency (CRI) is characterized by multiglandular hyperplasia.MethodsIn this study, we investigated the effects of the calcimimetic NPS R-568 on the parathyroid gland in rats with CRI induced by ligation of the renal arteries and severe secondary HPT induced by dietary phosphorus loading.

Michihito Wada; Nobuo Nagano; Yoshihiro Furuya; Ji Chin; Edward F Nemeth; John Fox

2000-01-01

400

Long-term, open-label, phase III multicenter study of tamsulosin in benign prostatic hyperplasia  

Microsoft Academic Search

Objectives. To investigate the long-term efficacy and safety of tamsulosin in patients with benign prostatic hyperplasia and to monitor the increases and decreases in therapeutic response over time. Tamsulosin, a uroselective alpha-adrenergic receptor antagonist for the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia, targets alpha1A-adrenergic receptors of prostatic smooth muscle with greater affinity than the vascular

Perinchery Narayan; Herbert Lepor

2001-01-01

401

Radioactive stents delay but do not prevent in-stent neointimal hyperplasia  

Microsoft Academic Search

BACKGROUND: Restenosis after conventional stenting is almost exclusively caused by neointimal hyperplasia. Beta-particle-emitting radioactive stents decrease in-stent neointimal hyperplasia at 6-month follow-up. The purpose of this study was to evaluate the 1-year outcome of (32)P radioactive stents with an initial activity of 6 to 12 microCi using serial quantitative coronary angiography and volumetric ECG-gated 3D intravascular ultrasound (IVUS). METHODS AND

I. Patrick Kay; Alexander J. Wardeh; Ken Kozuma; A. H. M. Knook; A. Thury; P. W. J. C. Serruys; D. P. Foley; P. C. Levendag; Giessen van der W. J; G. Sianos

2001-01-01

402

Acute inflammation initiates the regenerative response in the adult zebrafish brain.  

PubMed

The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular microinjection of immunogenic particles and immunosuppression assays, we showed that inflammation is required and sufficient for enhancing the proliferation of neural progenitors and subsequent neurogenesis by activating injury-induced molecular programs that can be observed after traumatic brain injury. We also identified cysteinyl leukotriene signaling as an essential component of inflammation in the regenerative process of the adult zebrafish brain. Thus, our results demonstrate that in zebrafish, in contrast to mammals, inflammation is a positive regulator of neuronal regeneration in the central nervous system. PMID:23138980

Kyritsis, Nikos; Kizil, Caghan; Zocher, Sara; Kroehne, Volker; Kaslin, Jan; Freudenreich, Dorian; Iltzsche, Anne; Brand, Michael

2012-11-08

403

Modeling and optimization of a regenerative fuel cell system using the ASPEN process simulator  

NASA Astrophysics Data System (ADS)

The Hydrogen-Oxygen Regenerative Fuel Cell System was identified as a key component for energy storage in support of future lunar missions. Since the H2-O2 regenerative electrochemical conversion technology has not yet been tested in space applications, it is necessary to implement predictive techniques to develop initial feasible system designs. The ASPEN simulation software furnishes a constructive medium for analyzing and for optimizing such systems. A rudimentary regenerative fuel cell system design was examined using the ASPEN simulator and this modular approach allows for easy addition of supplementary ancillary components and easy integration with life support systems. The modules included in the preliminary analyses may serve as the fundamental structure for more complicated energy storage systems.

Maloney, Thomas M.; Leibecki, Harold F.

1990-01-01

404

Modeling and optimization of a regenerative fuel cell system using the ASPEN process simulator  

NASA Astrophysics Data System (ADS)

The Hydrogen-Oxygen Regenerative Fuel Cell System was identified as a key component for energy storage in support of future lunar missions. Since the H2-O2 regenerative electrochemical conversion technology has not yet been tested in space applications, it is necessary to implement predictive techniques to develop initial feasible system designs. The ASPEN simulation software furnishes a constructive medium for analyzing and optimizing such systems. A rudimentary regenerative fuel cell system design was examined using the ASPEN simulator and this modular approach allows for easy addition of supplementary ancillary components and easy integration with life support systems. The modules included in the preliminary analyses may serve as the fundamental structure for more complicated energy storage systems.

Maloney, Thomas M.; Leibecki, Harold F.

405

Multi-walled carbon nanotubes inhibit regenerative axon growth of dorsal root ganglia neurons of mice  

PubMed Central

Recent observations have demonstrated that nanomaterials may be toxic to human tissue. While the ability of nano-scaled particulate matter is known to cause a range of problems in respiratory system, recent observations suggest that the nervous system may be vulnerable as well. In the current paper we asked whether exposure of primary neuronal cell cultures to nanoparticles might compromise regenerative axon growth. Regenerative response was triggered by performing a conditioning lesion of sciatic nerve five days prior to collection of dorsal root ganglia (DRG). DRG neurons were plated at a low density and incubated with multi-walled carbon nanotubes (MWCNT) (0.1 – 10 ?g/ml in 10% of surfactant in saline) overnight. The experiments showed that exposure of DRG cultures to MWCNT significantly impaired regenerative axonogenesis without concomitant cell death. These results indicate that MWNCTs may have detrimental effect on nerve regeneration and may potentially trigger axonal pathology.

Wu, Di; Pak, Elena S.; Wingard, Christopher J.; Murashov, Alexander K.

2012-01-01

406

Generalized ideal reference cycle for regenerative refrigeration: Part 2. Adiabatic systems  

NASA Astrophysics Data System (ADS)

A generalized ideal reference cycle for regenerative refrigeration systems is discussed. The cycle has adiabatic processes of compression and expansion. Cyclic heat addition to and rejection from the cycle occur at constant pressure or constant volume immediately preceding the regenerative thermal processes. These are assumed to occur partly at constant volume, partly at constant pressure. Equations are developed for cycle work, heat lifted, coefficient of performance and the pressure ratio: mean effective/maximum cycle pressures. Various special cases are deduced from the generalized analysis including the pseudo-Stirling and pseudo-Ericsson cycles. Results are presented for the Stirling and pseudo-Stirling cycles to illustrate the effect of volume compression ratio and regenerative effectiveness on the cycle Coefficient of Performance. The pressure ratio p mean/p max for the same two cycles are compared to a function of the volume compression ratio.

Walker, G.

407

Investigation of the part-load performance of two 1. 12 MW regenerative marine gas turbines  

SciTech Connect

Regenerative and intercooled-regenerative gas turbine engines with low pressure ratio have significant efficiency advantages over traditional aero-derivative engines of higher pressure ratios, and can compete with modern diesel engines for marine propulsion. Their performance is extremely sensitive to thermodynamic-cycle parameter choices and the type of components. The performance of two 1.12 MW (1,500 hp) regenerative gas turbines are predicted with computer simulations. One engine has a single-shaft configuration, and the other has a gas-generator/power-turbine combination. The latter arrangement is essential for wide off-design operating regime. The performance of each engine driving fixed-pitch and controllable-pitch propellers, or an AC electric bus (for electric-motor-driven propellers) is investigated. For commercial applications the controllable-pitch propeller may have efficiency advantages (depending on engine type and shaft arrangements). For military applications the electric drive provides better operational flexibility.

Korakianitis, T.; Beier, K.J. (Washington Univ., St. Louis, MO (United States). Dept. of Mechanical Engineering)

1994-04-01

408

Pseudoepitheliomatous hyperplasia in lichen sclerosus of the vulva.  

PubMed

Small tentacles or separated nests of squamous cells in the dermis are not uncommonly seen in long-standing vulvar lichen sclerosus (LS) associated with epidermal thickening. We recently encountered a case where separated nests of well-differentiated squamous cells in the dermis were difficult to distinguish from squamous cell carcinoma (SCC). Further biopsies showed similar nests originating from every hair follicle. We postulated a diagnosis of multifocal pseudoepitheliomatous hyperplasia (PEH) to explain this phenomenon. Because we could find no reference to PEH in the setting of LS, we reviewed the biopsies of 92 women with extragenital and vulvar LS with and without carcinoma to determine its frequency and histological appearance. The study population, which excluded the index case, comprised 10 women with extra-anogenital LS, 58 with vulvar LS without carcinoma, and 24 with vulvar LS with carcinoma. The presence of PEH, epidermal thickness, predominant dermal collagen change, degree of inflammation, and presence of fibrin and red blood cells were recorded. The presence or absence of lichen simplex chronicus (LSC), squamous cell hyperplasia (SCH), and differentiated vulvar intraepithelial neoplasia (VIN) were recorded. PEH was identified only in vulvar LS, where it was seen in 7/58 (12.1%) women without carcinoma, 1/24 (8.3%) with carcinoma, and 0/10 (0%) with extra-anogenital LS. Two forms of PEH were seen: predominantly epidermal 7/8 (87.5%) and predominantly follicular 1/8 (12.5%). PEH was associated with increased epidermal thickness, less dermal edema, more dermal inflammation, fresh fibrin, and red blood cell extravasation. In all cases, there was associated LSC, but there was no SCH or differentiated VIN. In conclusion, PEH may explain many of the cases of dermal tentacles and separated squamous nests in vulvar LS with LSC. The association with fresh fibrin and red blood cells suggests that PEH might be a reaction to tissue damage. PEH is distinguished from SCC by its lack of atypia, confinement to the abnormal collagen, and limited growth. The pathologist must be careful about making a diagnosis of PEH in LS with epidermal thickening, looking carefully for basal atypia and other features of differentiated VIN in the overlying epidermis or dermal proliferation. We do not know whether PEH occurs in differentiated VIN and, if it does, how it could be distinguished from SCC. PMID:12496699

Lee, Eung Seok; Allen, David; Scurry, James

2003-01-01

409

Reversion of gingival hyperplasia in a heart transplant patient upon interruption of cyclosporine therapy.  

PubMed

A heart transplant patient undergoing a combined cyclosporine and prednisone treatment was monitored during the 18 months following transplantation. A complete oral and dental examination was performed in each of the first six months after transplantation, and then in the 9th, 12th, 15th, and 18th months. The data collected included gingival hyperplasia secondary to cyclosporine use, and clinical and periodontal variables. Histological studies were also conducted on gingival tissue samples in months 1, 3, 9, 15, and 18. Cyclosporine treatment was replaced by azathioprine treatment in month 10 because the patient was experiencing nephrotoxicity. Between months 9 and 18, gingival hyperplasia regressed by 26.5% due to a reduction in the fibrous connective tissue mass, fibroblasts, and inflammatory infiltration. The control group included 13 heart transplant patients subject to equivalent conditions except discontinuance of cyclosporine treatment; seven of the patients had developed hyperplasia by month 9. Average hyperplasia in the control group increased by 2% between months 9 and 18; only one patient showed a 6.2% decrease in hyperplasia. This provides further evidence for the causal relationship between cyclosporine therapy and gingival hyperplasia, and suggests that this side-effect is reversible. PMID:9084329

Somacarrera, M L; Lucas, M; Acero, J

410

Molecular basis for the regenerative properties of a secretion of the mollusk Cryptomphalus aspersa.  

PubMed

A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antioxidant SOD and GST activities. In addition, SCA stimulated fibroblast proliferation and rearrangement of the actin cytoskeleton. Additional mechanisms involved in the regenerative effect of SCA included the stimulation of extracellular matrix assembly and the regulation of metalloproteinase activities. Together, these effects provide an array of molecular mechanisms underlying SCA-induced cellular regeneration and postulate its use in regeneration of wounded tissue. PMID:17912020

Brieva, A; Philips, N; Tejedor, R; Guerrero, A; Pivel, J P; Alonso-Lebrero, J L; Gonzalez, S

2007-10-02

411

Pulse compression with a high-energy Nd:YAG regenerative amplifier system  

SciTech Connect

We describe a method for the generation of readily synchronizable, near-transform-limited, 1064-nm, 6-mJ pulses with {lt}20-ps duration at a repetition rate of 20 Hz. The method employs chirped pulse amplification of spectrally broadened and temporally stretched pulses from a cw mode-locked Nd:YAG laser in a commercial Nd:YAG regenerative amplifier followed by pulse compression with a grating pair. Linear amplification subsequent to regenerative amplification is not required with this method, although higher energies would be easily obtained. {copyright} 1997 Optical Society of America

Venturo, V.A.; Joly, A.G.; Ray, D. [Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, P.O. Box 999 K2-14, Richland, Washington 99352 (United States)

1997-07-01

412

Deposited RuO 2–IrO 2\\/Pt electrocatalyst for the regenerative fuel cell  

Microsoft Academic Search

A bifunctional RuO2–IrO2\\/Pt electrocatalyst for the unitized regenerative fuel cell (URFC) was synthesized by colloid deposition and characterized by analytical methods like TEM, XRD, etc. The result reveals that RuO2–IrO2 was well dispersed and deposited on the surface of Pt black. With deposited RuO2–IrO2\\/Pt as the catalyst of oxygen electrode, the performance of fuel cell\\/water electrolysis of unitized regenerative fuel

Yangjian Zhang; Cheng Wang; Nianfang Wan; Zongqiang Mao

2007-01-01

413

Field test results of a dry low NOâ combustion system for the MS3002J regenerative cycle gas turbine  

Microsoft Academic Search

A dry low NOâ combustion system for the MS3002J regenerative cycle gas turbine has been developed and successfully installed at two pipeline compressor stations. Preparation for the DLN retrofits began with initial field testing of the conventional system intended to characterize some of the unique features of the two-shaft, regenerative cycle machine that might affect the proposed premixed combustor design.

J. R. Maughan; K. M. Elward; S. M. de Pietro; P. J. Bautista

1997-01-01

414

FUNDAMENTAL AREAS OF PHENOMENOLOGY (INCLUDING APPLICATIONS): An Ultra-Broadband Spatially Dispersed Regenerative Amplifier Free from Spatial Chirp  

NASA Astrophysics Data System (ADS)

An ultra-broadband Ti:sapphire regenerative amplifier based on spatially dispersed amplification is demonstrated experimentally Departing from previous reports, a new design of the cavity gets the amplified pulse free from spatial chirp. Utilizing this new regenerative amplifier, chirped pulses with bandwidth (FWHM) of about 80 nm are obtained, and the bandwidth is limited only by that of the incident seed pulses.

Li, Chuang; Leng, Yu-Xin; Zhang, Chun-Mei; Liang, Xiao-Yan; Li, Ru-Xin; Xu, Zhi-Zhan

2008-06-01

415

Critical review of lasers in benign prostatic hyperplasia (BPH).  

PubMed

• Laser treatment of benign prostatic hyperplasia has challenged transurethral resection of the prostate (TURP) due to advances in laser technology, better understanding of tissue-laser interactions and growing clinical experience. • Various lasers have been introduced including neodymium: yttrium aluminium garnet (YAG), holmium (Ho):YAG, potassium titanyl phosphate:YAG, thulium(Tm) and diode laser. Based on the different wave-length dependent laser-prostatic tissue interactions, the main techniques are coagulation, vaporization, resection and enucleation. • The present review aims to help urologists to distinguish and to critically evaluate the role of different laser methods in the treatment by using an evidence-based approach. It also details further evidence for use in specific patient groups (in retention, on anticoagulation) and addresses the issues of cost and learning curve. • Coagulation-based techniques have been abandoned; holmium ablation/resection of the prostate has been superseded by the enucleation technique Ho-laser enucleation of the prostate (HoLEP). The short-term efficacy of the emerging laser treatments such as diode and Tm prostatectomy has been suggested by low quality studies. HoLEP and photoselective vaporization of the prostate (PVP) represent valid clinical alternatives to TURP. HoLEP is the most rigorously analysed laser technique with durable efficacy for any prostate size and low early and late morbidity. PVP has grown in acceptance and popularity but long-term results from high quality studies are pending. PMID:21438974

Gravas, Stavros; Bachmann, Alexander; Reich, Oliver; Roehrborn, Claus G; Gilling, Peter J; De La Rosette, Jean

2011-04-01

416

Carney complex and other conditions associated with micronodular adrenal hyperplasias.  

PubMed

Carney complex (CNC) is a multiple neoplasia syndrome that is inherited in an autosomal dominant manner and is characterized by skin tumors and pigmented lesions, myxomas, schwannomas, and various endocrine tumors. Inactivating mutations of the PRKAR1A gene coding for the regulatory type I-? (RI?) subunit of protein kinase A (PKA) are responsible for the disease in most CNC patients. The overall penetrance of CNC among PRKAR1A mutation carriers is near 98%. Most PRKAR1A mutations result in premature stop codon generation and lead to nonsense-mediated mRNA decay. CNC is genetically and clinically heterogeneous, with specific mutations providing some genotype-phenotype correlation. Phosphodiesterase-11A (the PDE11A gene) and -8B (the PDE8B gene) mutations were found in patients with isolated adrenal hyperplasia and Cushing syndrome, as well in patients with PPNAD. Recent evidences demonstrated that dysregulation of cAMP/PKA pathway can modulate other signaling pathways and contributes to adrenocortical tumorigenesis. PMID:21115159

Almeida, Madson Q; Stratakis, Constantine A

2010-12-01

417

Neonatal screening for congenital adrenal hyperplasia in Japan.  

PubMed

A nationwide screening test for congenital adrenal hyperplasia (CAH) was first initiated in Japan in 1989, over 20 years ago, and it is now 30 years since a pilot study was initiated in Sapporo in 1982. The incidence of 21-hydroxylase deficiency in Japan is about 1/18,000 persons, which is similar to that in other countries. The effectiveness of early detection and treatment of CAH in Japan has been demonstrated by cost-benefit analyses. However, the false-positive rate of CAH screening in preterm infants remains high compared to screening tests for term infants. To improve the positive predictive value, we have employed 21-hydroxylase gene (CYP21A2) analysis on dried blood spots and high performance liquid chromatography (HPLC) to measure 17-hydroxyprogesterone, and currently use tandem mass spectrometry (LC-MS/MS) as a screening technique. We suggest that LC-MS/MS should be used in the future to improve the accuracy of CAH screening in Japan. PMID:23330248

Tajima, Toshihiro; Fujikura, Kaori; Fukushi, Masaru; Hotsubo, Tomoyuki; Mitsuhashi, Yu

2012-10-01

418

A case of congenital adrenal hyperplasia mimicking Cushing's syndrome.  

PubMed

Congenital adrenal hyperplasia (CAH) is characterized by decreased adrenal hormone production due to enzymatic defects and subsequent rise of adrenocorticotrophic hormone that stimulates the adrenal cortex to become hyperplastic, and sometimes tumorous. As the pathophysiology is basically a defect in the biosynthesis of cortisol, one may not consider CAH in patients with hypercortisolism. We report a case of a 41-yr-old man with a 4 cm-sized left adrenal tumorous lesion mimicking Cushing's syndrome who was diagnosed with CAH. He had central obesity and acanthosis nigricans involving the axillae together with elevated 24-hr urine cortisol level, supporting the diagnosis of Cushing's syndrome. However, the 24-hr urine cortisol was suppressed by 95% with the low dose dexamethasone suppression test. CAH was suspected based on the history of precocious puberty, short stature and a profound suppression of cortisol production by dexamethasone. CAH was confirmed by a remarkably increased level of serum 17-hydroxyprogesterone level. Gene mutation analysis revealed a compound heterozygote mutation of CYP21A2 (I173N and R357W). PMID:23166432

Kim, Hye Jeong; Kang, Mira; Kim, Jae Hyeon; Kim, Sun Wook; Chung, Jae Hoon; Min, Yong-Ki; Lee, Moon-Kyu; Kim, Kwang-Won; Lee, Myung-Shik

2012-10-30

419

Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome  

PubMed Central

Background: Kaempferia parviflora rhizome is used as a folk medicine in Thailand for the treatment of various symptoms. In the present study, the inhibitory activities of extract from K. parviflora rhizome against 5?-reductase (5?R) were subjected. Furthermore, the effects of the extract from K. parviflorar hizome in benign prostate hyperplasia (BPH) were studied using the model mice. Materials and Methods: Preparations of extracts from the rhizomes of K. parviflora, Curcuma zedoaria and Zingiber officinale, and methoxyflavones isolated from K. parviflora was used for 5?R inhibition assay. The effects of K. parviflora extract on growth suppression for the prostates and seminal vesicles were performed based on the Hershberger's method. The K. parviflora extract was administered to castrated mice for 14 days. Results: K. parviflora extract showed more potent inhibitory activity on 5?R than C. zedoaria and Z. officinale extracts. The active principles were identified as 3,5,7,3’,4’-pentamethoxyflavone and 5,7,3’,4’-tetramethoxyflavone by activity guided fractionation. Furthermore, K. parviflora extract suppressed the weights of prostates and seminal vesicles in BPH model rats by daily administration for 14 days. Conclusion: These results indicate that K. parviflora extract can be a promising agent for the treatment of BPH.

Murata, Kazuya; Hayashi, Hirotaka; Matsumura, Shinichi; Matsuda, Hideaki

2013-01-01

420

A Case of Congenital Adrenal Hyperplasia Mimicking Cushing's Syndrome  

PubMed Central

Congenital adrenal hyperplasia (CAH) is characterized by decreased adrenal hormone production due to enzymatic defects and subsequent rise of adrenocorticotrophic hormone that stimulates the adrenal cortex to become hyperplastic, and sometimes tumorous. As the pathophysiology is basically a defect in the biosynthesis of cortisol, one may not consider CAH in patients with hypercortisolism. We report a case of a 41-yr-old man with a 4 cm-sized left adrenal tumorous lesion mimicking Cushing's syndrome who was diagnosed with CAH. He had central obesity and acanthosis nigricans involving the axillae together with elevated 24-hr urine cortisol level, supporting the diagnosis of Cushing's syndrome. However, the 24-hr urine cortisol was suppressed by 95% with the low dose dexamethasone suppression test. CAH was suspected based on the history of precocious puberty, short stature and a profound suppression of cortisol production by dexamethasone. CAH was confirmed by a remarkably increased level of serum 17-hydroxyprogesterone level. Gene mutation analysis revealed a compound heterozygote mutation of CYP21A2 (I173N and R357W).

Kim, Hye Jeong; Kang, Mira; Kim, Jae Hyeon; Kim, Sun Wook; Chung, Jae Hoon; Min, Yong-Ki; Lee, Moon-Kyu; Kim, Kwang-Won

2012-01-01

421

Role of laser therapy in benign prostate hyperplasia (BPH)  

NASA Astrophysics Data System (ADS)

Benign prostatic hyperplasia (BPH) is a common disease in males older than 50 years of age. 75-80% of this population is considered to have some degree of BPH causing clinical symptoms and requiring urological treatment. Transurethral resection of the prostate (TUR-P) is currently the standard surgical treatment modality for BPH. In an attempt to minimize the need for hospitalization and the associated perioperative and postoperative morbidity, alternatives have been sought. Various types of laser techniques such as interstitial laser coagulation and side-firing technology have been proposed. Numerous studies have shown that laser procedures safely and effectively reduce the volume of the prostate. Intra- and postoperative bleeding are nearly unknown complications for laser procedures, whereas this is the most relevant complication for the TUR-P. Due to significant tissue edema after laser treatment, patients commonly show delayed time to void adequately and, therefore, catheter drainage is often necessary for 3 to 21 days. Retrograde ejaculation is reported to occur less (0- 10%) compared to TUR-P (greater than 60%). Urinary tract infections are very common after interstitial laser coagulation. Although not many long-term clinical data are available, various studies have shown that BPH patients improve in symptom score, flow rate and post-void residual up to 3 years after laser treatment. This paper presents a concise review of efficacy, advantages and disadvantages of the most frequently used laser techniques as well as the long-term clinical data compared to TUR-P.

de Riese, Werner T.; Sharpe, Brent A.; Aronoff, David B.; Mittemeyer, Bernhard T.

2001-05-01

422

Relationship between endothelial dysfunction and nocturia with benign prostatic hyperplasia.  

PubMed

Abstract Objective. There are limited data on whether there is an association between nocturia, benign prostatic hyperplasia (BPH) and endothelial dysfunction. The aim of the present study was to evaluate whether there is an association between nocturia and endothelial dysfunction in patients with BPH. Material and methods. Forty-two men with a diagnosis of BPH and 42 age-matched controls were enrolled. All patients were assessed for frequency and duration of nocturia, and prostate volume, completed the International Prostate Symptom Score (IPSS) questionnaire, and underwent brachial flow-mediated dilatation (FMD) evaluation. Results. There was a negative correlation between FMD and frequency of nocturia (r = -0.879, p < 0.0001). Moreover, there was a negative correlation between duration of nocturia and FMD (r = -0.890, p < 0.0001). In addition, FMD was significantly decreased in the BPH group compared with the control group (6.0 ± 0.09 to 7.8 ± 0.10%) (p = 0.0001). Conclusion. In patients with BPH, nocturia is associated with endothelial dysfunction and may be an insidious risk factor for cardiovascular disease. PMID:23323759

Inci, Mehmet; Sarli, Bahadir; Davarci, Mursel; Yalcinkaya, Fatih Rustu; Rifaio?lu, Murat Mehmet; Davran, Ramazan; Arica, Secil; Motor, Sedat; Demirba?, Onur

2013-01-17

423

Benign prostatic hyperplasia (BPH) management in the primary care setting.  

PubMed

Benign prostate hyperplasia (BPH) occurs in up to 50% of men by age 50, and the incidence increases with age. This common clinical problem is diagnosed by history, including the International Prostate Symptom Score (IPSS) questionnaire, and physical examination by digital rectal examination (DRE). Initial management for BPH includes lifestyle modification, and smooth muscle relaxant alpha blocker therapy. Alpha blockers usually take effect quickly within 3-5 days, and have minimal side effects. Current commonly used alpha blockers include the selective alpha blockers tamsulosin (Flomax), alfusosin (Xatral), and silodosin (Rapaflo). For patients with larger prostates, the 5-alpha reductase inhibitor class (finasteride (Proscar) and dutasteride (Avodart)) work effectively to shrink prostate stroma resulting in improved voiding. The 5-ARI class of drugs, in addition to reducing prostate size, also reduce the need for future BPH-related surgery, and reduce the risk of future urinary retention. Drugs from the phosphodiesterase-5 (PDE-5) inhibitor class may now be considered for treating BPH. Once daily 5 mg tadalafil has been shown to improve BPH-related symptoms and is currently approved to treat patients with BPH. Referral to a urologist can be considered for patients with a rising prostate-specific antigen (PSA), especially while on 5-ARI, failure of urinary symptom control despite maximal medical therapy, suspicion of prostate cancer, hematuria, recurrent urinary infections, urinary retention, or renal failure. Currently the primary care physician is armed with multiple treatment options to effectively treat men with symptomatic BPH. PMID:23089343

Kapoor, Anil

2012-10-01

424

Focal nodular hyperplasia of the liver: an unusual association with diabetes mellitus in a child and review of literature  

PubMed Central

Hepatic hemangioma, adenoma and focal nodular hyperplasia are the most frequent benign lesions of the liver, but they are all infrequent among pediatric population. The reports of focal nodular hyperplasia in children have recently increased in number, with many cases associated to drug intake, particularly to chemotherapy. We here describe, to our knowledge, the first case of focal nodular hyperplasia in association with diabetes mellitus in childhood.

2010-01-01

425

Prevention of bronchial hyperplasia by EGFR pathway inhibitors in an organotypic culture model.  

PubMed

Lung cancer is the leading cause of cancer-related mortality worldwide. Early detection or prevention strategies are urgently needed to increase survival. Hyperplasia is the first morphologic change that occurs in the bronchial epithelium during lung cancer development, followed by squamous metaplasia, dysplasia, carcinoma in situ, and invasive tumor. This study was designed to determine the molecular mechanisms that control bronchial epithelium hyperplasia. Using primary normal human tracheobronchial epithelial (NHTBE) cells cultured by using the 3-dimensional (3D) organotypic method, we found that the epidermal growth factor receptor (EGFR) ligands, EGF, TGF-?, and amphiregulin induced hyperplasia, as determined by cell proliferation and multilayered epithelium formation. We also found that EGF induced increased cyclin D1 expression, which plays a critical role in bronchial hyperplasia; this overexpression was mediated by activating the mitogen-activated protein kinase pathway but not the phosphoinositide 3-kinase/Akt signaling pathway. Erlotinib, an EGFR tyrosine kinase inhibitor, and U0126, a MAP/ERK kinase (MEK) inhibitor, completely inhibited EGF-induced hyperplasia. Furthermore, a promoter analysis revealed that the activator protein-1 transcription factor regulates EGF-induced cyclin D1 overexpression. Activator protein-1 depletion by using siRNA targeting its c-Jun component completely abrogated EGF-induced cyclin D1 expression. In conclusion, we showed that bronchial hyperplasia can be modeled in vitro by using primary NHTBE cells maintained in a 3D organotypic culture. EGFR and MEK inhibitors completely blocked EGF-induced bronchial hyperplasia, suggesting that they have a chemopreventive role. PMID:21505178

Lee, Jangsoon; Ryu, Seung-Hee; Kang, Shin Myung; Chung, Wen-Cheng; Gold, Kathryn Ann; Kim, Edward S; Hittelman, Walter N; Ki Hong, Waun; Koo, Ja Seok

2011-04-19

426

Disorders in cytokine gene expression in endometrial hyperplasia and effect of hormone therapy.  

PubMed

We studied local expression of insulin-like growth factor 1, insulin-like growth factor receptor, epithelial growth factor, transforming growth factor beta2, PCNA, TNF-alpha, type I TNF receptor, Fas, FasL, IFN-gamma, IL-1beta, IL-4, IL-6, IL-8, IL-10, and IL-12 genes in intact and hyperplastic endometrium. Endometrial hyperplasia was associated with reduced production of TNF-alpha (p<0.05), PCNA (p<0.05), and epithelial growth factor mRNA and enhanced production of Fas mRNA (p<0.01). The expression of TNF-R1, IL-1beta, and IL-12 genes decreased only in glandular cystic hyperplasia (p<0.05 for all genes), expression of insulin-like growth factor 1 gene decreased only in adenomatous hyperplasia (p<0.05). Dufaston therapy of glandular cystic hyperplasia and zoladex therapy of adenomatous hyperplasia normalized expression of Fas receptor, PCNA, and insulin-like growth factor 1 genes, while the expression of IFN-gamma and IL-6 genes, which was normal in hyperplasia, decreased (p<0.05). Zoladex therapy decreased the production of transforming growth factor beta2 (p<0.05) and IL-1beta (p<0.01) mRNA, dufaston therapy decreased production of TNF-alpha (p<0.05) and IL-4 mRNA (p<0.05). Hence, both apoptosis and proliferative activity were suppressed in endometrial hyperplasia, and hormone therapy created prerequisites for transition of the endometrium into the normal proliferation stage. PMID:16027816

Sukhikh, G T; Zhdanov, A V; Davydova, M P; Slukina, T V; Chernukha, G E; Samoilova, T E; Smetnik, V P

2005-02-01

427

Optimization of the alignment sensitivity and energy stability of the NIF regenerative amplifier cavity  

NASA Astrophysics Data System (ADS)

The work to improve the energy stability of the regenerative amplifier for the NIF is described. This includes a fast feed-forward system, designed to regulate the output energy of the regen by monitoring how quickly a pulse builds up over many round trips. Shot-to-shot energy fluctuations of all elements prior to the regen may be compensated for in this way, at the expense of a loss of approximately 50 percent. Also included is a detailed study into the alignment sensitivity of the regen cavity, with the goal of quantifying the effect of misalignment on the output energy. This is done by calculating the displacement of the eigenmode by augmenting the cavity ABCD matrix with the misalignment matrix elements, E, F. In this way, cavity misalignment issues due to thermal loading of the gain medium are investigated. Alternative cavity designs, which reduce the alignment sensitivity and therefore the energy drift over periods of continuous operation, are considered. Alterations to the amplifier head design are also considered.

Hopps, N. W.; Wilcox, Russell B.; Hermann, Mark R.; Martinez, Mikael D.; Padilla, E. H.; Crane, John K.

1999-07-01

428

Non-regenerative radio transmission systems for personal communications base station links  

Microsoft Academic Search

An analysis is made of the effect of applying a non-regenerative radio transmission system to base station links in personal communications. A discussion is presented of the models and the cost function of networks. These costs are estimated by finding the parameters which minimize the total cost. The results are as follows: (1) For transmission, the SCM\\/concentrating method is more

N. Fujimoto; T. Kuroda; H. Hoshino; J. Segawa; A. Hasimoto

1991-01-01

429

Experiment on a continuous heat regenerative adsorption refrigerator using spiral plate heat exchanger as adsorbers  

Microsoft Academic Search

Spiral plate heat exchangers were proposed to be used as adsorbers, and a prototype heat regenerative adsorption refrigerator using the activated carbon-methanol pair was developed and tested. The adsorption system using 12 kg activated carbon has a cycle time of 40 min., meanwhile 14 kg ice per day was made.

R. Z. Wang; J. Y. Wu; Y. X. Xu; Y. Teng; W. Shi

1998-01-01

430

Neural Network Self-adaptive PID Control for Driving and Regenerative Braking of Electric Vehicle  

Microsoft Academic Search

In order to deal with the main problems of electric vehicle (EV), such as the short driving range, the short life of batteries, the variation of the road state and driving mode and so on, based on constructing the main circuit diagram of the EV's control system and researching driving and regenerative braking process, the mathematical model of the system

Jianbo Cao; Binggang Cao; Wenzhi Chen; Peng Xu

2007-01-01

431

Comparative studies on plant range size: Linking reproductive and regenerative traits in two Ipomoea species  

NASA Astrophysics Data System (ADS)

Reproductive and regenerative traits associated with colonization and persistence ability may determine plant range size. However, few comparative studies on plant distribution have assessed these traits simultaneously. Pollinator richness and frequency of visits, autonomous self-pollination ability, reproductive output (i.e., reproductive traits), seed bank strategy and seedling density (i.e., regenerative traits) were compared between the narrowly distributed Ipomoea rubriflora O'Donnell (Convolvulaceae) and its widespread congener Ipomoea purpurea (L.) Roth. The narrowly distributed species showed higher ecological specialization to pollinators and lower autonomous self-pollination ability. Frequency of visits, natural seed/ovule ratio and fruit set, and total fruit production did not differ between species. However, the number of seeds produced per fruit was lower in the narrowly distributed species, translating into lower total seed production per plant. Indeed, I. rubriflora formed smaller transient and persistent seed banks and showed lower seedling density than the widespread I. purpurea. These reproductive and regenerative trait results suggest that the narrowly distributed species may have lower colonization and persistence ability than its widespread congener. They further suggest that the negative effects of lower fecundity in the narrowly distributed species might persist in time through the long-lasting effects of total seed production on seed bank size, reducing the species' ability to buffered environmental stochasticity. However, other regenerative traits, such as seed size, and processes such as pre- and post-dispersal seed predation, might modulate the effects of plant fecundity on plant colonization and persistence ability and thus range size.

Astegiano, Julia; Funes, Guillermo; Galetto, Leonardo

2010-09-01

432

Control of neural interfacing in peripheral nerves through regenerative molecular guidance  

Microsoft Academic Search

Regenerative peripheral nerve interfaces have been proposed as viable alternatives for the natural control of robotic prosthetic devices. However, random axonal pathfinding during peripheral nerve regeneration leads to mixed populations of sensory and motor neurons at the electrode interfaces preventing the precise identification of the modality nature of the recorded action potentials; motor or specific sensory sub-modalities. This study present

Parisa Lotfi; Mario I. Romero-Ortega

2011-01-01

433

Heat transfer within the flow passages of a regenerative air preheater  

Microsoft Academic Search

A computational procedure to predict the transient heat transfer processes inside the flow passages of a regenerative type air preheater has been developed by modifying the methods available in the literature for steady flows in rectangular ducts. The method can be applied to passages with arbitrarily shaped cross-sections in the plane normal to the direction of the flow and constant

Nelik

1990-01-01

434

Electromechanical regenerative actuator with fault tolerance capability for automotive chassis applications  

Microsoft Academic Search

This paper investigates an electromechanical regenerative actuator (EMR) for automotive chassis applications. The actuator system comprises an electric machine, a ball screw and a controller. The designs of these three components are studied first. Control algorithms were then developed for both converter and inverter topologies. A prototype actuator was fabricated and tested in the lab. It was found that the

Lei Hao; Chandra Namuduri

2011-01-01

435

Molecular Basis for the Regenerative Properties of a Secretion of the Mollusk Cryptomphalus aspersa  

Microsoft Academic Search

A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antioxidant SOD and GST activities. In addition, SCA stimulated fibroblast proliferation and rearrangement of the actin cytoskeleton.

A. Brieva; N. Philips; R. Tejedor; A. Guerrero; J. P. Pivel; J. L. Alonso-Lebrero; S. Gonzalez

2008-01-01

436

Modeling hydraulic regenerative hybrid vehicles using AMESim and Matlab\\/Simulink  

Microsoft Academic Search

This paper presents the overview of the simulation modeling of a hydraulic system with regenerative braking used to improve vehicle emissions and fuel economy. Two simulation software packages were used together to enhance the simulation capability for fuel economy results and development of vehicle and hybrid control strategy. AMESim, a hydraulic simulation software package modeled the complex hydraulic circuit and

Alfred Lynn; Edzko Smid; Moji Eshraghi; Niall Caldwell; Dan Woody

2005-01-01

437

The effect of tool geometry on regenerative instability in ultrasonic vibration cutting  

Microsoft Academic Search

Ultrasonic vibration cutting as a cutting process has been widely used in the precision machining of difficult-to-cut materials due to an enhanced cutting stability and increased productivity. The authors' previous researches have shown that chatter vibration prediction is made possible by the suggested cutting model. This paper is an attempt to determine cutting parameters based on regenerative chatter prediction in

M. Xiao; Q. M. Wang; K. Sato; S. Karube; T. Soutome; H. Xu

2006-01-01

438

The Application of an Enamel Matrix Protein Derivative (Emdogain®) in Regenerative Periodontal Therapy: A Review  

Microsoft Academic Search

Regenerative periodontal therapy aims at reconstitution of the lost periodontal structures such as new formation of root cementum, periodontal ligament and alveolar bone. Findings from basic research indicate that enamel matrix protein derivative (EMD) has a key role in periodontal wound healing. Histological results from animal and human studies have shown that treatment with EMD promotes periodontal regeneration. Moreover, clinical

Anton Sculean; Frank Schwarz; Jürgen Becker; Michel Brecx

2007-01-01

439

TV picture-tube manufacturer uses regenerative catalytic oxidizer to reduce VOC emissions  

SciTech Connect

Toshiba Display Services, a television picture-tube manufacturer in Horseheads, NY, recently was able to meet stringent state regulations to reduce emissions from two of its film applications lines by installing a regenerative catalytic oxidation system. Toshiba officials initially evaluated several technologies to control volatile organic compounds. After deciding that oxidation was the best technology for its facility, the company invited a number of suppliers to submit proposals. Because all of the oxidation technologies considered by Toshiba had the capability to achieve the destruction and removal efficiency requirement, the company combined the second and third decision elements and conducted an in-depth comparison of the initial capital and ongoing operating costs for each proposal. Officials narrowed the field to two systems--the lowest-cost regenerative thermal oxidation system on the market and a regenerative catalytic oxidation system. The company selected St. Louis, Mo.-based Monsanto Enviro-Chem Systems Inc., to install its DynaCycle{reg_sign} regenerative catalytic oxidation system, marking the first Dyna-Cycle installation in a US television picture-tube facility.

NONE

1995-11-01

440

Regenerative Response and Endocrine Disrupters in Crinoid Echinoderms: An Old Experimental Model, a New Ecotoxicological Test  

Microsoft Academic Search

The regenerative phenomena that reproduce developmental processes in adult organisms and are regulated by endocrine and neurohumoral mechanisms can provide new sensitive tests for monitoring the effects of exposure to anthropogenic chemicals such as endocrine disrupter (ED) contaminants. These pollutants in fact can be bioaccumulated by the organisms, causing dysfunctions in steroid hormone production\\/metabolism and activities and inducing dramatic effects

M. D. Candia Carnevali

441

Optimum cycle parameters of coal fired closed cycle gas turbine in regenerative and combined cycle configurations  

Microsoft Academic Search

This paper presents the methodology developed for the estimation of thermodynamic performance and reports the optimum cycle parameters of coal fired CCGT in regenerative and combined cycle configurations using air, helium and carbon dioxide as working gases. A rigorous approach has been followed for the determination of the cycle efficiency by assuming the specific heat of working gases as a

Rao

1982-01-01

442

Preliminary evaluation of a heat pipe heat exchanger on a regenerative turbofan  

Microsoft Academic Search

A preliminary evaluation was made of a regenerative turbofan engine using a heat pipe heat exchanger. The heat exchanger had an effectiveness of 0.70, a pressure drop of 3 percent on each side, and used sodium for the working fluid in the stainless steel heat pipes. The engine was compared to a reference turbofan engine originally designed for service in

Kraft

1975-01-01

443

Preliminary Evaluation of a Heat Pipe Heat Exchanger on a Regenerative Turbofan.  

National Technical Information Service (NTIS)

A preliminary evaluation was made of a regenerative turbofan engine using a heat pipe heat exchanger. The heat exchanger had an effectiveness of 0.70, a pressure drop of 3 percent on each side, and used sodium for the working fluid in the stainless steel ...

G. A. Kraft

1975-01-01

444

Characterization of a high-gain picosecond flash-lamp-pumped Nd:YAG regenerative amplifier.  

PubMed

We evaluate the performance of a novel 10-Hz picosecond Nd:YAG regenerative amplifier configured as a selffiltering unstable resonator. Pulse energies of ~60 mJ in ~100 psec at 1.06 microm are achieved using a single 6-mm-diameter Nd:YAG rod, while mode-matching requirements are minimized. PMID:19746102

Dawson, M D; Schroeder, W A; Norwood, D P; Smirl, A L; Weston, J; Ettelbrick, R N; Aubert, R

1988-11-01

445

Ultrafast semiconductor laser-diode-seeded Cr:LiSAF regenerative amplifier system  

Microsoft Academic Search

An ultrafast, hybrid mode-locked semiconductor laser-diode system has been used to seed a flash-lamp-pumped Cr:LiSAF regenerative amplifier system, producing subpicosecond pulses with millijoule output pulse energy. This system has the potential to eliminate argon-ion-pumped-based, ultrafast laser systems.

Peter J. Delfyett; Alex Yusim; Steve Grantham; Sangyoun Gee; Kai Gabel; Martin Richardson; Gerard Alphonse; John Connolly

1997-01-01

446

Ultrafast semiconductor laser-diode-seeded Cr:LiSAF regenerative amplifier system.  

PubMed

An ultrafast, hybrid mode-locked semiconductor laser-diode system has been used to seed a flash-lamp-pumped Cr:LiSAF regenerative amplifier system, producing subpicosecond pulses with millijoule output pulse energy. This system has the potential to eliminate argon-ion-pumped-based, ultrafast laser systems. PMID:18253351

Delfyett, P J; Yusim, A; Grantham, S; Gee, S; Gabel, K; Richardson, M; Alphonse, G; Connolly, J

1997-05-20

447

All-solid-state diode-pumped Cr:LiSAF femtosecond oscillator and regenerative amplifier  

Microsoft Academic Search

3+  :LiSrAlF6?(Cr:LiSAF) regenerative amplifier, seeded by a diode-pumped Cr:LiSAF femtosecond oscillator. The amplifier produced pulses\\u000a of less than 200 fs duration and greater than 1 ?J energy at repetition rates of up to 25 kHz.

R. Mellish; S. C. W. Hyde; N. P. Barry; R. Jones; P. M. W. French; J. R. Taylor; C. J. van der Poel; A. Valster

1997-01-01

448

Regenerative Treatment of an Immature, Traumatized Tooth With Apical Periodontitis: Report of a Case  

Microsoft Academic Search

This case report describes the treatment of a necrotic immature permanent central incisor with complete crown fracture, suspected root fracture, and sinus tract, which was not treated with conventional apexification techniques. Instead, a regenerative approach based on the trauma literature's methods for revascularization was provided. The root canal was gently debrided of necrotic tissue with a sharp spoon excavator and

Elisabetta Cotti; Manuela Mereu; Daniela Lusso

449

The Optimization and Application Research on Power Plant Circulating Water Waste Heat Regenerative Thermal System  

Microsoft Academic Search

In the dissertation, the thermal efficiency of the power plant is improved when the waste heat and the condensate of the Power Plant Circulating Water (PPCW) is recycled and heated. However, the regenerative steam extraction system is deviated from the optimal design condition, which decreases the thermal efficiency. In order to achieve the maximum thermal efficiency- the maximum energy saving,

Bi Qingsheng; Ma Yanliang

2010-01-01

450

Stem Cells in Drug Discovery, Tissue Engineering, and Regenerative Medicine: Emerging Opportunities and Challenges  

Microsoft Academic Search

Stem cells, irrespective of their origin, have emerged as valuable reagents or tools in human health in the past 2 decades. Initially, a research tool to study fundamental aspects of developmental biology is now the central focus of generating transgenic animals, drug discovery, and regenerative medicine to address degenerative diseases of multiple organ systems. This is because stem cells are

Victor Sanjit Nirmalanandhan; G. Sitta Sittampalam

2009-01-01

451

Exploring the Process of Creative Supervision: Initial Findings Regarding the Regenerative Model.  

ERIC Educational Resources Information Center

This study explored "creative supervision" using qualitative methods of data collection and analysis. Findings include a new model of counselor supervision. Rather than resting on a developmental notion of supervision goals, the Regenerative model empowers students to identify their own learning needs by integrating expressive arts activities…

Neswald-McCalip, Rhonda; Sather, Jerome; Strati, Jennifer Vigil; Dineen, Julia

2003-01-01

452

Nuclear reprogramming: A key to stem cell function in regenerative medicine  

Microsoft Academic Search

The goal of regenerative medicine is to restore form and function to damaged tissues. One potential therapeutic approach involves the use of autologous cells derived from the bone marrow (bone marrow-derived cells, BMDCs). Advances in nuclear transplantation, experimental heterokaryon formation and the observed plasticity of gene expression and phenotype reported in multiple phyla provide evidence for nuclear plasticity. Recent observations

Jason Pomerantz; Helen M. Blau

2004-01-01

453

Self-assembled collagen–human mesenchymal stem cell microspheres for regenerative medicine  

Microsoft Academic Search

Mesenchymal stem cells (MSCs)-based therapy is a promising approach in regenerative medicine and tissue engineering. However, the outcomes of existing treatments have not been satisfactory owing to suboptimal localization to implantation site, poor viability, low engraftment efficacy and lack of functional remodeling of the delivered cells. Therefore, adopting an effective cell delivery modality is among the biggest technological challenges for

Barbara P. Chan; T. Y. Hui; C. W. Yeung; J. Li; I. Mo; G. C. F. Chan

2007-01-01

454

Great Expectations: Private Sector Activity in Tissue Engineering, Regenerative Medicine, and Stem Cell Therapeutics  

Microsoft Academic Search

This report draws upon data from a variety of sources to provide a detailed estimate of the current scope of private sector development and commercial activity in the aggregate field comprising tissue engi- neering, regenerative medicine, and stem cell therapeutics. Economic activity has grown a remarkable fivefold in the past 5 years. As of mid-2007 approximately 50 firms or business

Michael J. Lysaght; Ana Jaklenec; Elizabeth Deweerd

2008-01-01

455

Hunt for pluripotent stem cell – Regenerative medicine search for almighty cell  

Microsoft Academic Search

Regenerative medicine and tissue engineering are searching for a novel stem cell based therapeutic strategy that will allow for efficient treatment or even potential replacement of damaged organs. The pluripotent stem cell (PSC), which gives rise to cells from all three germ lineages, seems to be the most ideal candidate for such therapies. PSC could be extracted from developing embryos.

Mariusz Z. Ratajczak; Ewa K. Zuba-Surma; Marcin Wysoczynski; Wu Wan; Janina Ratajczak; Wojciech Wojakowski; Magda Kucia

2008-01-01

456

A chemical approach to stem-cell biology and regenerative medicine  

Microsoft Academic Search

An improved understanding of stem-cell and regenerative biology, as well as a better control of stem-cell fate, is likely to produce treatments for many devastating diseases and injuries. Chemical approaches are starting to have an increasingly important role in this young field. Attention has focused on chemical approaches that allow the precise manipulation of cells in vitro to obtain homogeneous

Yue Xu; Yan Shi; Sheng Ding

2008-01-01

457

Purity and the dangers of regenerative medicine: Regulatory innovation of human tissue-engineered technology  

Microsoft Academic Search

This paper examines the development of innovation in human tissue technologies as a form of regenerative medicine, firstly by applying ‘pollution ideas’ to contemporary trends in its risk regulation and to the processes of regulatory policy formation, and secondly by analysing the classificatory processes deployed in regulatory policy. The analysis draws upon data from fieldwork and documentary materials with a

Alex Faulkner; Julie Kent; Ingrid Geesink; David FitzPatrick

2006-01-01

458

Cellular sources of new pancreatic ? cells and therapeutic implications for regenerative medicine  

Microsoft Academic Search

Replacing missing insulin-producing ? cells to treat diabetes is a major challenge for regenerative medicine. A better understanding of ?-cell embryogenesis and regeneration in adult life is needed to devise means to derive these specialized cells in sufficiently large numbers from stem or precursor cells. It is also critical to ensure that any surrogate or regenerated ? cells have perfectly

Philippe A. Halban

2004-01-01

459

Polymers for tissue engineering, medical devices, and regenerative medicine. Concise general review of recent studies  

Microsoft Academic Search

Recently investigated applications of polymeric materials for tissue engineering, regenerative medicine, implants, stents, and medical devices are described in the present review. Papers published during the last 2 years about polymeric materials used for preparation of various polymeric scaffolds, methods of fabrication of such scaffolds and their effectiveness in providing support for cell growth and development into various tissues and

Joseph Jagur-Grodzinski

2006-01-01

460

[Determination of clinical efficacy of REGEN-D 150 preparation for local treatment of burns].  

PubMed

Clinical efficacy of preparation REGEN-D 150 for local treatment of burns was analyzed. In accordance to the data obtained, the preparation application for the burns treatment have secured the local inflammatory reaction reduction in the affection zone, reparative processes optimization in the burn wound and saving the functional possibilities of phagocytic cells on optimal level. PMID:22013676

Kozynets', H P; Osadcha, O I; Boiars'ka, H M; Tsyhankov, V P; Nazarenko, V M; Solodky?, Iu A

2011-07-01

461

Chirped pulse amplification of 300 fs pulses in an alexandrite regenerative amplifier  

Microsoft Academic Search

The amplification of fsec dye-laser pulses up to the 3.5-mJ level in an alexandrite regenerative amplifier is discussed. An expansion\\/compression system using different gratings allows chirped amplification techniques to be used to produce peak powers upwards of 1 GW. Limitations in the chirped pulse amplification of ultrashort pulses due to intracavity dispersive elements are discussued.

Maurice Pessot; Jeff Squier; Philippe Bado; Gerard Mourou; Donald J. Harter

1989-01-01

462

A 100-W class regenerative fuel cell system for lunar and planetary missions  

Microsoft Academic Search

The Japan Aerospace Exploration Agency (JAXA) is developing polymer electrolyte fuel cell (PEFC) systems that can be operated under isolated low-gravity and closed environments. In the present study, we combine the PEFC with an electrolyzer in order to realize a regenerative fuel cell. Ideally, if a single cell can be operated as a fuel cell and the cell can be

Yoshitsugu Sone

2011-01-01

463

Performance of polypyrrole-impregnated composite electrode for unitized regenerative fuel cell  

Microsoft Academic Search

We have proposed a novel deposition method of thin Pt catalysts onto Nafion membranes impregnated with polypyrrole (PPy) for unitized regenerative fuel cells (URFCs). We demonstrated that the polypyrrole impregnated into Nafion membrane not only offered electronic conduction pathways necessary to sink electrons generated from the chemical reduction of platinic chloride, but also enhanced the direct loading of Pt particles

Hankyu Lee; Jiyun Kim; Jongho Park; Yungil Joe; Taehee Lee

2004-01-01

464

Regenerative fuel cells for High Altitude Long Endurance Solar Powered Aircraft  

Microsoft Academic Search

High Altitude Long Endurance (HALE) unmanned missions appear to be feasible using a lightweight, high efficiency, span-loaded, Solar Powered Aircraft (SPA) which includes a Regenerative Fuel Cell (RFC) system and novel tankage for energy storage. An existing flightworthy electric powered flying wing design was modified to incorporate present and near-term technologies in energy storage, power electronics, aerodynamics, and guidance and

F. Mitlitsky; N. J. Colella; B. Myers; C. J. Anderson

1993-01-01

465

Effect of fabrication methods of bifunctional catalyst layers on unitized regenerative fuel cell performance  

Microsoft Academic Search

In order to understand the origins of performance variations in unitized regenerative fuel cells (URFCs), bifunctional catalyst layers (BCLs) fabricated with two different methods, i.e., ink deposition on membrane or GDL, were designed in this paper. The performances of the two different methods were evaluated, and their reaction dynamics were measured by electrochemical impedance spectra. The different BCLs, caused by

Guobao Chen; Huamin Zhang; Haipeng Ma; Hexiang Zhong

2009-01-01

466

A novel membrane electrode assembly for improving the efficiency of the unitized regenerative fuel cell  

Microsoft Academic Search

A novel membrane electrode assembly (MEA) for unitized regenerative fuel cell (URFC) has been developed. The MEA was fabricated to improve the efficiency of the URFC by a Nafion-pyrolyzed method. The polarization curves for fuel cell and water electrolysis modes of URFC operation both were investigated. The MEA improved water management and minimized mass transport limitations. The URFC using the

Guobao Chen; Huamin Zhang; Jinbing Cheng; Yuanwei Ma; Hexiang Zhong

2008-01-01

467

Influence of PTFE coating on gas diffusion backing for unitized regenerative polymer electrolyte fuel cells  

Microsoft Academic Search

Gas diffusion backings (GDBs) with various PTFE loadings for unitized regenerative polymer fuel cells (URFCs) were prepared and the relations between the PTFE loading amount and the URFC performance were examined. As for the GDB of the hydrogen electrode, both the fuel cell and water electrolysis performances were not affected by the amount of PTFE loading on the hydrogen side

Tsutomu Ioroi; Takanori Oku; Kazuaki Yasuda; Naokazu Kumagai; Yoshinori Miyazaki

2003-01-01

468

Thin film electrocatalyst layer for unitized regenerative polymer electrolyte fuel cells  

Microsoft Academic Search

Thin film electrocatalyst layers with various PTFE and Nafion contents for unitized regenerative polymer electrolyte fuel cells (URFCs) were prepared by the paste method and the performance as URFC electrodes was examined. Comparing the terminal voltage versus current density curves of the URFC, it was found that the PTFE content in the electrocatalyst layer affected only the fuel cell performance;

Tsutomu Ioroi; Kazuaki Yasuda; Zyun Siroma; Naoko Fujiwara; Yoshinori Miyazaki

2002-01-01

469

A regenerative zinc air fuel cell for industrial and specialty vehicles  

Microsoft Academic Search

Metallic Power has demonstrated a regenerative zinc\\/air fuel cell for applications in industrial and specialty vehicles. The fuel cell uses zinc pellets and atmospheric oxygen to generate electric current. The reaction product is zinc oxide, which is collected in a tank. In its present stage of development, the 36 V fuel cell will deliver approximately 6 kWh, with a maximum

S. Smedley

2000-0