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1

Development of Nodular Regenerative Hyperplasia (NRH) with Portal Hypertension Following the Administration of Oxaliplatin for the Recurrence of Colon Cancer.  

PubMed

Nodular regenerative hyperplasia (NRH) is associated with autoimmune and hematologic diseases and may lead to portal hypertension. We herein report a case of NRH diagnosed based on a liver biopsy. A 63-year-old woman developed esophageal varices and splenomegaly. She had undergone surgery for transverse colon cancer 24 years earlier and received systemic chemotherapy (FOLFOX4 including oxaliplatin) to treat lymph node metastasis 21 years after the operation. The present liver biopsy confirmed NRH, and, after two years, she received endoscopic injection sclerotherapy. Oxaliplatin was suspected to be the causative agent of NRH in this case. Therefore, physicians must consider the possibility of NRH in patients who receive chemotherapy. PMID:25748953

Takaya, Hiroaki; Kawaratani, Hideto; Nakanishi, Keisuke; Takeyama, Shinya; Morioka, Chie; Sawai, Masayoshi; Toyohara, Masahisa; Fujimoto, Masao; Yoshiji, Hitoshi; Yamao, Junichi; Fukui, Hiroshi

2015-01-01

2

Thorotrast associated nodular regenerative hyperplasia of the liver.  

PubMed

A case of nodular regenerative hyperplasia (NRH) of the liver is described in association with exposure to the radiographic contrast medium Thorotrast. This is the first case in which the pathological findings have been fully documented. It is suggested that NRH may have developed through Thorotrast induced damage to portal vein radicles. PMID:10070340

Beer, T W; Carr, N J; Buxton, P J

1998-12-01

3

Nodular Regenerative Hyperplasia in Common Variable Immunodeficiency  

PubMed Central

Purpose Patients with Common Variable Immunodeficiency (CVID) are subject to the development of a liver disease syndrome known as nodular regenerative hyperplasia (NRH). The purpose of this study was to define the characteristics and course of this complication of CVID. Methods CVID patients were evaluated by retrospective and prospective clinical course review. Liver biopsy specimens were evaluated for evidence of NRH and studied via RT-PCR for cytokine analysis. Results NRH in our CVID patient population occurred in approximately 5% of the 261 patients in our total CVID study group, initially presenting in most cases with an elevated alkaline phosphatase level. While in some patients the disease remained static, in a larger proportion a more severe disease developed characterized by portal hypertension, the latter leading to hypersplenism with neutropenia and thrombocytopenia and, in some cases, to ascites. In addition, a substantial proportion of patients either developed or presented initially with an autoimmune hepatitis-like (AIH-like) liver disease that resulted in severe liver dysfunction and, in most cases to death due to infections. The liver histologic findings in these AIH-like patients were characterized by underlying NRH pattern with superimposed interface hepatitis, lymphocytic infiltration and fibrosis. Immunologic studies of biopsies of NRH patients demonstrated the presence of infiltrating T cells producing IFN-?, suggesting that the NRH is due to an autoimmune process. Conclusion Overall, these studies provide evidence that NRH may not be benign but, can be a severe and potentially fatal disease complication of CVID that merits close monitoring and intervention. PMID:23420139

Fuss, Ivan J.; Friend, Julia; Yang, Zhiqong; He, Ping; Hooda, Lubna; Boyer, James; Xi, Liqiang; Raffeld, Mark; Kleiner, David E.; Heller, Theo; Strober, Warren

2013-01-01

4

Human immunodeficiency virus and nodular regenerative hyperplasia of liver: A systematic review  

PubMed Central

AIM: To investigate the diagnosis, pathogenesis, natural history, and management of nodular regenerative hyperplasia (NRH) in patients with human immunodeficiency virus (HIV). METHODS: We performed a systematic review of the medical literature regarding NRH in patients with HIV. Inclusion criteria include reports with biopsy proven NRH. We studied the clinical features of NRH, in particular, related to its presenting manifestation and laboratory values. Combinations of the following keywords were implemented: “nodular regenerative hyperplasia”, “human immunodeficiency virus”, “noncirrhotic portal hypertension”, “idiopathic portal hypertension”, “cryptogenic liver disease”, “highly active antiretroviral therapy” and “didanosine”. The bibliographies of these studies were subsequently searched for any additional relevant publications. RESULTS: The clinical presentation of patients with NRH varies from patients being completely asymptomatic to the development of portal hypertension – namely esophageal variceal bleeding and ascites. Liver associated enzymes are generally normal and synthetic function well preserved. There is a strong association between the occurrence of NRH and the use of antiviral therapies such as didanosine. The management of NRH revolves around treating the manifestations of portal hypertension. The prognosis of NRH is generally good since liver function is preserved. A high index of suspicion is required to make a identify NRH. CONCLUSION: The appropriate management of HIV-infected persons with suspected NRH is yet to be outlined. However, NRH is a clinically subtle condition that is difficult to diagnose, and it is important to be able to manage it according to the best available evidence. PMID:24653794

Sood, Archita; Castrejón, Mariana; Saab, Sammy

2014-01-01

5

Nodular regenerative hyperplasia related portal hypertension in a patient with hypogammaglobulinaemia  

PubMed Central

Nodular regenerative hyperplasia (NRH) of liver is a relatively rare liver disorder, but a frequent cause of noncirrhotic portal hypertension. We present a lady with common variable immune deficiency who presented with upper gastrointestinal bleeding and deranged liver function tests but preserved synthetic function. Upper gastrointestinal endoscope showed bleeding gastric varices and non-bleeding oesophageal varices. Although her oesophageal varices were eradicated by repeated endoscopic band ligation, the gastric varices failed to resolve after repeated endoscopic histocryl injection and she eventually needed transjugular intrahepatic portosystemic shunt placement. Liver biopsy showed NRH. We review the association of hypogammaglobinaemia and NRH and discuss the appropriate management of portal hypertension in NRH. PMID:23801845

Lal, Barun Kumar; Stanley, Adrian

2013-01-01

6

6Thioguanine Associated Nodular Regenerative Hyperplasia in Patients With Inflammatory Bowel Disease May Induce Portal Hypertension  

Microsoft Academic Search

BACKGROUND:Recent studies suggest an association between 6-thioguanine (6-TG) therapy and hepatic nodular regenerative hyperplasia (NRH) in patients with inflammatory bowel disease (IBD). An influence of 6-TG on portal pressure remains to be determined. The aim of the study was to examine the functional relevance of long-term 6-TG treatment on hepatic hemodynamics in IBD patients and its association with NRH.METHODS:Patients treated

Arnulf Ferlitsch; Alexander Teml; Walter Reinisch; Gregor Ulbrich; Fritz Wrba; Monika Homoncik; Alfred Gangl; Markus Peck-Radosavljevic; Harald Vogelsang

2007-01-01

7

Nodular Regenerative Hyperplasia and Portal Hypertension in a Patient with Coeliac Disease  

PubMed Central

Nodular regenerative hyperplasia (NRH) of the liver is often associated with rheumatologic or lymphoproliferative disorders and a cause of portal hypertension in some patients. We report the case of a 71-year-old patient with celiac disease and unexplained portal hypertension. Biopsy of the liver revealed NRH as the underlying cause. The patient did not suffer from an autoimmune, rheumatologic or lymphoproliferative disease. A thrombophilic disorder that might cause NRH was ruled out. Celiac disease is often associated with mild elevation of liver enzymes and steatosis of the liver, but the association with NRH was described in only a few patients. We discuss the possible relationship of celiac disease and NRH. PMID:22606433

Biecker, Erwin; Fischer, Hans-Peter; Schepke, Michael

2011-01-01

8

Thioguanin-induced nodular regenerative hyperplasia of the liver-ROC analysis of different MR techniques.  

PubMed

The aim of this study was to evaluate the diagnostic value of different magnetic resonance (MR) techniques for the diagnosis of nodular regenerative hyperplasia (NRH). Thirty-one patients with inflammatory bowel disease, who received 6-thioguanin, underwent liver biopsy and liver MRI on a 1.5-T MR system, with gadolinium and superparamagnetic iron oxide particles (SPIO). MR imaging (MRI) was evaluated independently as well as in consensus by two blinded readers, who received the following image sets: pre-contrast; pre-contrast and gadolinium-enhanced; pre-contrast and SPIO-enhanced and all images. The results were correlated with histopathology and diagnostic efficacy parameters were calculated. NRH was found in 13/31 patients. The set "all images" showed the highest sensitivity (84.6%), accuracy (77.4%) and negative predictive value (86.7%). However, results for gadolinium were only slightly inferior. The highest specificity (76.5%) was found for SPIO. The A(z) values of both readers were highest for gadolinium (mean A(z) = 0.824). It can be concluded that gadolinium-enhanced and SPIO-enhanced MRI enable an accurate diagnosis of NRH. Since gadolinium-enhanced MRI is very sensitive, it should be used for screening high-risk patients. SPIO-enhanced MRI is less sensitive, but more specific. The combination of both guarantees a high sensitivity and specificity and, therefore, is the diagnostic procedure of choice. PMID:17221208

Zech, Christoph J; Seiderer, Julia; Reinisch, Walter; Ochsenkuhn, Thomas; Schima, Wolfgang; Diebold, Joachim; Wrba, Fritz; Reiser, Maximilian F; Schoenberg, Stefan O

2007-07-01

9

Nodular regenerative hyperplasia of the liver: diagnosis by liver biopsy.  

PubMed Central

Specimens of liver obtained by needle biopsy from two patients with rheumatoid arthritis showed features of nodular regenerative hyperplasia. In one patient the nodularity was apparent on gross examination of the specimen. Portal hypertension was present in the other patient. The cause and pathogenesis of the disorder are poorly understood. Images FIG. 1 FIG. 2 FIG. 3 PMID:7388707

Qizilbash, A. H.; Castelli, M.

1980-01-01

10

Thiopurine-methyltransferase and inosine triphosphate pyrophosphatase polymorphism in a liver transplant recipient developing nodular regenerative hyperplasia on low-dose azathioprine.  

PubMed

The enzymes thiopurine-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) are involved in thiopurine metabolism. We describe a liver transplant recipient who presented with liver enzyme abnormalities after 78 months of low-dose azathioprine (AZA) therapy (less than 1 mg/kg). No underlying etiology of these abnormalities was identified after extensive analysis including repeated liver biopsy. Fifteen years after transplantation, the patient presented with variceal bleeding, liver biopsy showed nodular regenerative hyperplasia (NRH). TPMT*3C genotype was found in the patient's lymphocytes and heterozygous ITPA (94C>A) genotype was found in both patient and donor liver. These findings further emphasize the importance of pharmacogenetics in predicting NRH and other adverse events during AZA therapy. Furthermore, a high index of suspicion with early detection of NRH is crucial, as improvement seems only to occur in patients with compensated liver disease. Liver biopsy and discontinuation of AZA are recommended in case of liver enzyme abnormalities or signs of portal hypertension. PMID:18090994

Buster, Erik H C J; van Vuuren, Hanneke J; Zondervan, Pieter E; Metselaar, Herold J; Tilanus, Hugo W; de Man, Robert A

2008-01-01

11

Nodular regenerative hyperplasia of the liver, CREST syndrome and primary biliary cirrhosis: an overlap syndrome?  

PubMed Central

Nodular regenerative hyperplasia of the liver (NRHL) has been found in association with collagen vascular diseases, after drug therapy, with autoimmune disease, and with a variety of haematological disorders. The association of NRHL with the syndrome of Calcinosis cutis, Raynaud's phenomenon, oesophageal dysfunction, sclerodactyly and telangiectasia (CREST syndrome) has only been reported on two previous occasions. The liver disease usually associated with CREST syndrome is primary biliary cirrhosis (PBC) and recently nodular hyperplasia of the liver has been reported in patients with early stage PBC. We present a case of NRHL with CREST syndrome and serological and biochemical features of PBC, a newly recognised overlap syndrome. Images Figure PMID:2583572

McMahon, R F; Babbs, C; Warnes, T W

1989-01-01

12

Nodular regenerative hyperplasia of the liver, CREST syndrome and primary biliary cirrhosis: an overlap syndrome?  

PubMed

Nodular regenerative hyperplasia of the liver (NRHL) has been found in association with collagen vascular diseases, after drug therapy, with autoimmune disease, and with a variety of haematological disorders. The association of NRHL with the syndrome of Calcinosis cutis, Raynaud's phenomenon, oesophageal dysfunction, sclerodactyly and telangiectasia (CREST syndrome) has only been reported on two previous occasions. The liver disease usually associated with CREST syndrome is primary biliary cirrhosis (PBC) and recently nodular hyperplasia of the liver has been reported in patients with early stage PBC. We present a case of NRHL with CREST syndrome and serological and biochemical features of PBC, a newly recognised overlap syndrome. PMID:2583572

McMahon, R F; Babbs, C; Warnes, T W

1989-10-01

13

Nodular regenerative hyperplasia, portal vein thrombosis, and avascular hip necrosis due to hyperhomocysteinaemia  

PubMed Central

A male patient with portal hypertension, portal vein thrombosis, spontaneous splenorenal shunt formation, and encephalopathy, thought to have post-hepatitis B cirrhosis, is described. His condition deteriorated and necessitated liver transplantation. In the explant liver, nodular regenerative hyperplasia with pronounced vascular lesions both in portal venules and in arterioles was found instead of classical cirrhosis. Two years post-transplant he developed bilateral ischaemic femur head necrosis. The three disorders (portal vein thrombosis, nodular regenerative hyperplasia, and ischaemic hip necrosis) seemed to be due to a common vasculopathy induced by hyperhomocyteinaemia. Genetic studies showed that he carried a mutation in the gene encoding for formation of methylenetetrahydrofolate reductase. Treatment with folic acid combined with pyridoxine (vitamin B6) and cyanocobalamin (vitamin B12) normalised his serum homocysteine levels. PMID:15951553

Buchel, O; Roskams, T; Van Damme, B; Nevens, F; Pirenne, J; Fevery, J

2005-01-01

14

Abnormal liver function in common variable immunodeficiency disorders due to nodular regenerative hyperplasia  

PubMed Central

Patients with common variable immunodeficiency disorders are monitored for liver function test abnormalities. A proportion of patients develop deranged liver function and some also develop hepatomegaly. We investigated the prevalence of abnormalities and types of liver disease, aiming to identify those at risk and determine outcomes. The local primary immunodeficiency database was searched for patients with a common variable immunodeficiency disorder and abnormal liver function and/or a liver biopsy. Patterns of liver dysfunction were determined and biopsies reviewed. A total of 47 of 108 patients had deranged liver function, most commonly raised alkaline phosphatase levels. Twenty-three patients had liver biopsies. Nodular regenerative hyperplasia was found in 13 of 16 with unexplained pathology. These patients were more likely to have other disease-related complications of common variable immunodeficiency disorders, in particular non-coeliac (gluten insensitive) lymphocytic enteropathy. However, five had no symptoms of liver disease and only one died of liver complications. Nodular regenerative hyperplasia is a common complication of common variable immunodeficiency disorders but was rarely complicated by portal hypertension. PMID:18647320

Ward, C; Lucas, M; Piris, J; Collier, J; Chapel, H

2008-01-01

15

Pituitary Hyperplasia  

Microsoft Academic Search

Comprehensive article summarizing more than 25 years of experience with pituitary hyperplasia in surgical material. Morphologic forms of hyperplasiadiffuse and nodularare defined and, for comparison, the normal morphology, frequency and intraglandular distribution of cell types are briefly reviewed. All cell types can give rise to hyperplasia, although their frequency, extent and clinical importance widely vary. Somatotroph hyperplasia is rare; it

Eva Horvath; Kalman Kovacs; Bernd W. Scheithauer

1999-01-01

16

Regenerative Aerobraking  

NASA Technical Reports Server (NTRS)

NASA's exploration goals for Mars and Beyond will require new power systems and in situ resource utilization technologies. Regenerative aerobraking may offer a revolutionary approach for in situ power generation and oxygen harvesting during these exploration missions. In theory, power and oxygen can be collected during aerobraking and stored for later use in orbit or on the planet. This technology would capture energy and oxygen from the plasma field that occurs naturally during hypersonic entry using well understood principles of magnetohydrodynamics and oxygen filtration. This innovative approach generates resources upon arrival at the operational site, and thus greatly differs from the traditional approach of taking everything you need with you from Earth. Fundamental analysis, computational fluid dynamics, and some testing of experimental hardware have established the basic feasibility of generating power during a Mars entry. Oxygen filtration at conditions consistent with spacecraft entry parameters at Mars has been studied to a lesser extent. Other uses of the MHD power are presented. This paper illustrates how some features of regenerative aerobraking may be applied to support human and robotic missions at Mars.

Moses, Robert W.

2004-01-01

17

Research Councils UK Regenerative  

E-print Network

Research Councils UK Regenerative medicine #12;Regenerative medicine, the approach that seeks. The Regenerative Medicine Programme was set up by the Research Councils in 2008 to support the emergence of new to UK growth. The field of regenerative medicine is inherently interdisciplinary

Berzins, M.

18

Adrenal medullary hyperplasia. Hyperplasia-pheochromocytoma sequence.  

PubMed

We present a case of unilateral adrenal medullary hyperplasia in a 63-year-old woman with clinical signs and symptoms of pheochromocytoma unassociated with multiple endocrine neoplasia. The surgically removed adrenal gland revealed diffuse medullary hyperplasia with multiple micronodules measuring up to 2 mm. The micronodules were composed of enlarged chromaffin cells with atypia, histologically similar to those of pheochromocytoma, forming small solid alveolar patterns separated by a fibrovascular stroma. Removal of the hyperplastic adrenal gland resulted in disappearance of paroxysmal nocturnal hypertension and palpitation. These results suggest that diffuse and nodular medullary hyperplasia is the precursor of pheochromocytoma. PMID:2260475

Kurihara, K; Mizuseki, K; Kondo, T; Ohoka, H; Mannami, M; Kawai, K

1990-09-01

19

MRC CENTRE FOR REGENERATIVE  

E-print Network

HIGHLIGHTS MRC CENTRE FOR REGENERATIVE MEDICINE www.crm.ed.ac.uk Boosting cell production could developments in the MRC Centre for Regenerative Medicine (CRM). We have continued to strengthen our for Regenerative Medicine (SCRM) building, bringing together all our teams into a single state-of-the-art facility

20

Regenerative composition structures  

Microsoft Academic Search

A new class of random composition structures (the ordered analog of Kingman’s partition structures) is defined by a regenerative description of component sizes. Each regenerative composition structure is represented by a process of random sampling of points from an exponential distribution on the positive halfline, and separating the points into clusters by an independent regenerative random set. Examples are composition

Alexander Gnedin; Jim Pitman

2005-01-01

21

Benign prostate hyperplasia (BPH) - resources  

MedlinePLUS

Resources - benign prostatic hyperplasia (BPH); Prostate enlargement resources; BPH resources ... following organizations provide information on benign prostatic hyperplasia ( prostate enlargement ): National Kidney and Urologic Diseases Information Clearinghouse - ...

22

CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE  

E-print Network

CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE INSTITUTE FOR STEM CELL BIOLOGY & SCHOLAR TRAINING GRANT REGENERATIVE MEDICINE Pre-doctoral Scholar Application Deadline: June 30, 2011 Instructions page maximum) Research plans in stem cell biology/regenerative medicine (3 page maximum

Quake, Stephen R.

23

Angiolymphoid hyperplasia with eosinophilia.  

PubMed

We report a case of angiolymphoid hyperplasia with eosinophilia (ALHE). Histologically, some vessels were lined with plump endothelial cells. Infiltration by lymphocytes, histiocytes and eosinophils was marked. An arteriovenous malformation and vessels occluded by endothelial cell hyperplasia were present. PCNA staining gave positive results for the nuclei of many of the plump endothelial cells. Electron-microscopic findings disclosed increased metabolic activity in the cells. These observations suggest that the plump endothelial cells, characteristic of ALHE, have high metabolic activity. These results suggest that blood flow is increased by arteriovenous malformations and that blood pressure is elevated by occlusion, resulting in hyperplasia of plump endothelial cells and accelerated neovascularization. PMID:9649692

Endo, M; Shibata, M; Iwamoto, I; Suzuki, H; Hayakawa, M

1998-01-01

24

Regenerative (Regen) ECLSS Operations Water Balance  

NASA Technical Reports Server (NTRS)

In November 2008, the Water Regenerative System racks were launched aboard Space Shuttle flight, STS-126 (ULF2) and installed and activated on the International Space Station (ISS). These racks, consisting of the Water Processor Assembly (WPA) and Urine Processor Assembly (UPA), completed the installation of the Regenerative (Regen) ECLSS systems which includes the Oxygen Generator Assembly (OGA) that was launched 2 years prior. With the onset of active water management on the US segment of the ISS, a new operational concept was required, that of "water balance." Even more recently, in 2010 the Sabatier system came online which converts H2 and CO2 into water and methane. The Regen ECLSS systems accept condensation from the atmosphere, urine from crew, and processes that fluid via various means into potable water which is used for crew drinking, building up skip-cycle water inventory, and water for electrolysis to produce oxygen. Specification rates of crew urine output, condensate output, O2 requirements, toilet flush water and drinking needs are well documented and used as a general plan when Regen ECLSS came online. Spec rates are useful in long term planning, however, daily or weekly rates are dependent on a number of variables. The constantly changing rates created a new challenge for the ECLSS flight controllers, who are responsible for operating the ECLSS systems onboard ISS. This paper will review the various inputs to rate changes and inputs to planning events, including but not limited to; crew personnel makeup, Regen ECLSS system operability, vehicle traffic, water containment availability, and Carbon Dioxide Removal Assembly (CDRA) capability. Along with the inputs that change the various rates, the paper will review the different systems, their constraints and finally the operational means by which flight controllers manage this new challenge of "water balance."

Tobias, Barry

2010-01-01

25

Regenerative medicine primer.  

PubMed

The pandemic of chronic diseases, compounded by the scarcity of usable donor organs, mandates radical innovation to address the growing unmet needs of individuals and populations. Beyond life-extending measures that are often the last available option, regenerative strategies offer transformative solutions in treating degenerative conditions. By leveraging newfound knowledge of the intimate processes fundamental to organogenesis and healing, the emerging regenerative armamentarium aims to boost the aptitude of human tissues for self-renewal. Regenerative technologies strive to promote, augment, and reestablish native repair processes, restituting organ structure and function. Multimodal regenerative approaches incorporate transplant of healthy tissues into damaged environments, prompt the body to enact a regenerative response in damaged tissues, and use tissue engineering to manufacture new tissue. Stem cells and their products have a unique aptitude to form specialized tissues and promote repair signaling, providing active ingredients of regenerative regimens. Concomitantly, advances in materials science and biotechnology have unlocked additional prospects for growing tissue grafts and engineering organs. Translation of regenerative principles into practice is feasible and safe in the clinical setting. Regenerative medicine and surgery are, thus, poised to transit from proof-of-principle studies toward clinical validation and, ultimately, standardization, paving the way for next-generation individualized management algorithms. PMID:23809322

Terzic, Andre; Nelson, Timothy J

2013-07-01

26

Morphogenesis & Regenerative Medicine  

E-print Network

Morphogenesis Symposium & Regenerative Medicine May 27-29, 2009 Registration & Abstract submission will showcase some of the best research performed in morphogenesis and regenerative medicine. A wide range Francisco Haifan Lin Yale University Ruth Lehmann The Skirball Institute of Biomolecular Medicine #12;

Brodie III, Edmund D.

27

Congenital Adrenal Hyperplasia  

MedlinePLUS

... virilism Congenital adrenal hyperplasia (classic or nonclassic) CAH 21-hydroxylase deficiency Last Updated Date: 07/31/2013 Last Reviewed Date: 07/09/2013 Related A-Z Topics Adrenal Gland Disorders Cushing Syndrome Women's Health NICHD ...

28

Congenital hemifacial hyperplasia.  

PubMed

A case of true hemifacial hyperplasia is described. This is an unusual condition which produces facial asymmetry by a marked, unilateral, localised overgrowth of all the tissues in the affected area, including, the facial soft tissues, bones and teeth. The patient is an eight-year-old Caucasian girl with congenital hemihyperplasia of the right side of her face. PMID:3166970

Antoniades, K; Letsis, I; Karakasis, D

1988-08-01

29

Angiolymphoid hyperplasia with eosinophilia  

PubMed Central

A patient with multiple erythematous nodules on her posterior scalp presented to our dermatology clinic. Biopsy confirmed the diagnosis of angiolymphoid hyperplasia with eosinophilia. The etiology of this disorder is unclear. Several cases have been treated in the past with complete surgical excision, although the recurrence rate remains relatively high. PMID:25484503

Chitrapu, Prathyusha; Patel, Mahir; Readinger, Allison

2014-01-01

30

Congenital adrenal hyperplasia  

MedlinePLUS

... or inappropriately). Congenital adrenal hyperplasia can affect both boys and girls. About 1 in 10,000 to 18,000 ... penis but normal testes Well-developed muscles Both boys and girls will be tall as children but much shorter ...

31

Microscale Regenerative Heat Exchanger  

NASA Technical Reports Server (NTRS)

The device described herein is designed primarily for use as a regenerative heat exchanger in a miniature Stirling engine or Stirling-cycle heat pump. A regenerative heat exchanger (sometimes called, simply, a "regenerator" in the Stirling-engine art) is basically a thermal capacitor: Its role in the Stirling cycle is to alternately accept heat from, then deliver heat to, an oscillating flow of a working fluid between compression and expansion volumes, without introducing an excessive pressure drop. These volumes are at different temperatures, and conduction of heat between these volumes is undesirable because it reduces the energy-conversion efficiency of the Stirling cycle.

Moran, Matthew E.; Stelter, Stephan; Stelter, Manfred

2006-01-01

32

CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE  

E-print Network

CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE INSTITUTE FOR STEM CELL BIOLOGY & SCHOLAR TRAINING PROGRAM REGENERATIVE MEDICINE MD Research Scholar Application Deadline: August 23, 2013 Instructions in a research career in stem cell biology and regenerative medicine. c) This application is for a research

Quake, Stephen R.

33

CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE  

E-print Network

CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE INSTITUTE FOR STEM CELL BIOLOGY & SCHOLAR TRAINING PROGRAM REGENERATIVE MEDICINE MD Research Scholar Application Deadline: August 24, 2012 Instructions in a research career in stem cell biology and regenerative medicine. c) This application is for a research

Quake, Stephen R.

34

The Nonclassic Adrenal Hyperplasias  

Microsoft Academic Search

Nonclassic adrenal hyperplasia (NCAH) resulting from 11?-hydroxylase or 3?-hydroxysteroid dehydrogenase is very rare and may\\u000a not even exist in women presenting with hyperandrogenism in adulthood. Consequently, screening for these disorders in hyperandrogenic\\u000a patients is not generally necessary. Alternatively, 21-hydroxylase (21-OH)-deficient NCAH has been increasingly recognized\\u000a in adolescent or adult hyperandrogenic patients. It is now widely accepted that neither clinical presentation

Didier Dewailly; Ricardo Azziz

35

Hydrogels in Regenerative Medicine  

Microsoft Academic Search

Hydrogels,due totheiruniquebiocompatibility,flexiblemethodsofsynthesis, range of constituents, and desirable physical characteristics, have been the material of choice for many applications in regenerative medicine. They can serve as scaffolds that provide structural integrity to tissue constructs, control drug and protein delivery to tissues and cultures, and serve as adhesives or barriers between tissue and material surfaces. In this work, the properties of hydrogels

Brandon V. Slaughter; Shahana S. Khurshid; Omar Z. Fisher; Ali Khademhosseini; Nicholas A. Peppas

2009-01-01

36

Regenerative photonic therapy: Review  

NASA Astrophysics Data System (ADS)

After four decades of research of photobiomodulation phenomena in mammals in vitro and in vivo, a solid foundation is created for the use of photobiomodulation in regenerative medicine. Significant accomplishments are achieved in animal models that demonstrate opportunities for photo-regeneration of injured or pathological tissues: skin, muscles and nerves. However, the use of photobiomodulation in clinical studies leads to controversial results while negative or marginal clinical efficacy is reported along with positive findings. A thor ough analysis of requirements to the optical parameters (dosimetry) for high efficacy in photobimodulation led us to the conclusion that there are several misconceptions in the clinical applications of low level laser therapy (LLLT). We present a novel appr oach of regenerative photonic therapy (RPT) for tissue healing and regeneration that overcomes major drawbacks of LLLT. Encouraging clinical results on RPT efficacy are presented. Requirements for RPT approach and vision for its future development for tissue regeneration is discussed.

Salansky, Natasha; Salansky, Norman

2012-09-01

37

Regenerative feedback resonant circuit  

DOEpatents

A regenerative feedback resonant circuit for measuring a transient response in a loop is disclosed. The circuit includes an amplifier for generating a signal in the loop. The circuit further includes a resonator having a resonant cavity and a material located within the cavity. The signal sent into the resonator produces a resonant frequency. A variation of the resonant frequency due to perturbations in electromagnetic properties of the material is measured.

Jones, A. Mark; Kelly, James F.; McCloy, John S.; McMakin, Douglas L.

2014-09-02

38

Regenerative fuel cells  

NASA Technical Reports Server (NTRS)

A development status evaluation is presented for moderate-temperature, single-unit, regenerative fuel cells using either alkaline or solid polymer proton-exchange membrane (PEM) electrolytes. Attention is given to the results thus far obtained for Pt, Ir, Rh, and Na(x)Pt3O4 catalysts. Alkaline electrolyte tests have been performed on a half-cell basis with a floating-electrode cell; PEM testing has been with complete fuel cells, using Nafion 117.

Swette, Larry L.; Kackley, Nancy D.; Laconti, Anthony B.

1992-01-01

39

Regenerative rehabilitation: a new future?  

PubMed

Modern rehabilitation medicine is propelled by newfound knowledge aimed at offering solutions for an increasingly aging population afflicted by chronic debilitating conditions. Considered a core component of future health care, the rollout of regenerative medicine underscores a paradigm shift in patient management targeted at restoring physiologic function and restituting normative impact. Nascent regenerative technologies offer unprecedented prospects in achieving repair of degenerated, diseased, or damaged tissues. In this context, principles of regenerative science are increasingly integrated in rehabilitation practices as illustrated in the present Supplement. Encompassing a growing multidisciplinary domain, the emergent era of "regenerative rehabilitation" brings radical innovations at the forefront of healthcare blueprints. PMID:25310603

Perez-Terzic, Carmen; Childers, Martin K

2014-11-01

40

Regenerative air heater  

DOEpatents

A gas-cooled steel skirt is used to support a refractory cored brick matrix and dome structure in a high temperature regenerative air heater useful in magnetohydrodynamic power generation. The steel skirt thermally expands to accommodate the thermal expansion of the dome structure despite substantial temperature differential thereby reducing relative movement between the dome bricks. Gas cooling of the steel skirt allows the structure to operate above its normal temperature during clean-out cycles and also allows for the control of the thermal expansion of the steel skirt.

Hasselquist, P.B.; Baldner, R.

1980-11-26

41

Regenerative air heater  

DOEpatents

A gas-cooled steel skirt is used to support a refractory cored brick matrix and dome structure in a high temperature regenerative air heater useful in magnetohydrodynamic power generation. The steel skirt thermally expands to accommodate the thermal expansion of the dome structure despite substantial temperature differential thereby reducing relative movement between the dome bricks. Gas cooling of the steel skirt allows the structure to operate above its normal temperature during clean-out cycles and also allows for the control of the thermal expansion of the steel skirt.

Hasselquist, Paul B. (Maple Grove, MN); Baldner, Richard (Minnetonka, MN)

1982-01-01

42

Regenerative Sorption Refrigerator  

NASA Technical Reports Server (NTRS)

Two-stage sorption refrigerator achieves increased efficiency via regenerative-heating concept in which waste heat from praseodymium/cerium oxide (PCO) chemisorption compressor runs charcoal/krypton (C/Kr) sorption compressor. Waste heat from each PCO sorption compressor used to power surrounding C/Kr sorption compressor. Flows of heat in two compressor modules controlled by gas-gap thermal switches. Has no wearing moving parts other than extremely long life, room-temperature check valves operating about twice per hour. Virtually no measurable vibration, and has potential operating life of at least ten years.

Jones, Jack A.; Wen, Liang-Chi; Bard, Steven

1991-01-01

43

Regenerative combustion device  

DOEpatents

A regenerative combustion device having a combustion zone, and chemicals contained within the combustion zone, such as water, having a first equilibrium state, and a second combustible state. Means for transforming the chemicals from the first equilibrium state to the second combustible state, such as electrodes, are disposed within the chemicals. An igniter, such as a spark plug or similar device, is disposed within the combustion zone for igniting combustion of the chemicals in the second combustible state. The combustion products are contained within the combustion zone, and the chemicals are selected such that the combustion products naturally chemically revert into the chemicals in the first equilibrium state following combustion. The combustion device may thus be repeatedly reused, requiring only a brief wait after each ignition to allow the regeneration of combustible gasses within the head space.

West, Phillip B.

2004-03-16

44

PEM regenerative fuel cells  

NASA Technical Reports Server (NTRS)

This paper will update the progress in developing electrocatalyst systems and electrode structures primarily for the positive electrode of single-unit solid polymer proton exchange membrane (PEM) regenerative fuel cells. The work was done with DuPont Nafion 117 in complete fuel cells (40 sq cm electrodes). The cells were operated alternately in fuel cell mode and electrolysis mode at 80 C. In fuel cell mode, humidified hydrogen and oxygen were supplied at 207 kPa (30 psi); in electrolysis mode, water was pumped over the positive electrode and the gases were evolved at ambient pressure. Cycling data will be presented for Pt-Ir catalysts and limited bifunctional data will be presented for Pt, Ir, Ru, Rh, and Na(x)Pt3O4 catalysts as well as for electrode structure variations.

Swette, Larry L.; Laconti, Anthony B.; Mccatty, Stephen A.

1993-01-01

45

Regenerative braking device  

DOEpatents

Disclosed are several embodiments of a regenerative braking device for an automotive vehicle. The device includes a plurality of rubber rollers (24, 26) mounted for rotation between an input shaft (14) connectable to the vehicle drivetrain and an output shaft (16) which is drivingly connected to the input shaft by a variable ratio transmission (20). When the transmission ratio is such that the input shaft rotates faster than the output shaft, the rubber rollers are torsionally stressed to accumulate energy, thereby slowing the vehicle. When the transmission ratio is such that the output shaft rotates faster than the input shaft, the rubber rollers are torsionally relaxed to deliver accumulated energy, thereby accelerating or driving the vehicle.

Hoppie, Lyle O. (Birmingham, MI)

1982-01-12

46

Congenital lipoid adrenal hyperplasia  

PubMed Central

Congenital lipoid adrenal hyperplasia (lipoid CAH) is the most fatal form of CAH, as it disrupts adrenal and gonadal steroidogenesis. Most cases of lipoid CAH are caused by recessive mutations in the gene encoding steroidogenic acute regulatory protein (StAR). Affected patients typically present with signs of severe adrenal failure in early infancy and 46,XY genetic males are phenotypic females due to disrupted testicular androgen secretion. The StAR p.Q258X mutation accounts for about 70% of affected alleles in most patients of Japanese and Korean ancestry. However, it is more prevalent (92.3%) in the Korean population. Recently, some patients have been showed that they had late and mild clinical findings. These cases and studies constitute a new entity of 'nonclassic lipoid CAH'. The cholesterol side-chain cleavage enzyme, P450scc (CYP11A1), plays an essential role converting cholesterol to pregnenolone. Although progesterone production from the fetally derived placenta is necessary to maintain a pregnancy to term, some patients with P450scc mutations have recently been reported. P450scc mutations can also cause lipoid CAH and establish a recently recognized human endocrine disorder. PMID:25654062

2014-01-01

47

CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE  

E-print Network

CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE INSTITUTE FOR STEM CELL BIOLOGY & SCHOLAR TRAINING, are you a minority applicant? Yes No If yes, which minority? (i.e., African-American, Asian, Hispanic

Ford, James

48

CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE  

E-print Network

CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE INSTITUTE FOR STEM CELL BIOLOGY & SCHOLAR TRAINING applicant? Yes No If yes, which minority? (i.e., African-American, Asian, Hispanic, Native American Indian

Quake, Stephen R.

49

Pharmacotherapy for benign prostatic hyperplasia.  

PubMed Central

Benign prostatic hyperplasia is a benign neoplasm of the prostate seen in men of advancing age. Microscopic evidence of the disorder is seen in about 70% of men by 70 years of age, whereas symptoms requiring some form of surgical intervention occur in 30% of men during their lifetime. Although the exact cause of benign prostatic hyperplasia is not clear, it is well recognized that high levels of intraprostatic androgens are required for the maintenance of prostatic growth. In recent years, extensive surveys of patients undergoing transurethral resection of the prostate reveal an 18% incidence of morbidity that has essentially not changed in the past 30 years. This procedure is also the second highest reimbursed surgical therapy under Medicare. These findings have resulted in an intensive search for alternative therapies for prostatic hyperplasia. An alternative that has now been well defined is the use of alpha-adrenergic blockers to relax the prostatic urethra. This is based on findings that a major component of benign prostatic hyperplasia symptoms is spasm of the prostatic urethra and bladder neck, which is mediated by the alpha-adrenergic nerves. A second approach is to block androgens involved in maintaining prostate growth. Several such drugs are now available for clinical use, and we discuss their side effects and use. We also include the newer recommendations on evaluating benign prostatic hyperplasia that are cost-effective yet comprehensive. Images PMID:7528957

Narayan, P; Indudhara, R

1994-01-01

50

Carbon Nanotubes in Regenerative Medicine  

Microsoft Academic Search

\\u000a This chapter focuses on the latest developments in applications of carbonnanotubes (CNTs) for regenerative medicine. Regenerative\\u000a Medicine focuses on technologies to create functional tissues to repair or replace tissues or organs lost due to trauma or\\u000a disease. Carbon nonotubes (CNTs) have been under investigation in the past decade for an array of applications due to their\\u000a unique and versatile properties.

Bhavna S. Paratala; Balaji Sitharaman

51

Regenerative switching CMOS system  

DOEpatents

Complementary Metal Oxide Semiconductor (CMOS) Schottky barrier Field Effect Transistor systems, which are a seriesed combination of N and P-Channel MOSFETS, in which Source Schottky barrier junctions of the N and P-Channel Schottky barrier MOSFETS are electically interconnected, (rather than the Drains as in conventional diffused junction CMOS), which Schottky barrier MOSFET system demonstrates Regenerative Inverting Switching Characteristics in use are disclosed. Both the N and P-Channel Schottky barrier MOSFET devices are unique in that they provide operational Drain Current vs. Drain to Source voltage as a function of Gate voltage only where the polarities of the Drain voltage and Gate voltage are opposite, referenced to the Source as a common terminal, and where the polarity of the voltage applied to the Gate is appropriate to cause Channel inversion. Experimentally derived results which demonstrate and verify the operation of N and P-Channel Schottky barrier MOSFETS actually fabricated on P and N-type Silicon respectively, by a common procedure using vacuum deposited Chromium as a Schottky barrier forming metal, are also provided.

Welch, James D. (10328 Pinehurst Ave., Omaha, NE 68124)

1998-01-01

52

Regenerative switching CMOS system  

DOEpatents

Complementary Metal Oxide Semiconductor (CMOS) Schottky barrier Field Effect Transistor systems, which are a series combination of N and P-Channel MOSFETS, in which Source Schottky barrier junctions of the N and P-Channel Schottky barrier MOSFETS are electrically interconnected, (rather than the Drains as in conventional diffused junction CMOS), which Schottky barrier MOSFET system demonstrates Regenerative Inverting Switching Characteristics in use are disclosed. Both the N and P-Channel Schottky barrier MOSFET devices are unique in that they provide operational Drain Current vs. Drain to Source voltage as a function of Gate voltage only where the polarities of the Drain voltage and Gate voltage are opposite, referenced to the Source as a common terminal, and where the polarity of the voltage applied to the Gate is appropriate to cause Channel inversion. Experimentally derived results which demonstrate and verify the operation of N and P-Channel Schottky barrier MOSFETS actually fabricated on P and N-type Silicon respectively, by a common procedure using vacuum deposited Chromium as a Schottky barrier forming metal, are also provided. 14 figs.

Welch, J.D.

1998-06-02

53

Regenerative homoepitaxy of diamond  

SciTech Connect

InterScience, Inc. is a company founded in 1980 to pursue development of technology related to controlled fusion research for near term applications. During the first decade of the company`s existence, the strategic focus was the transfer of technology and know-how from the fusion program supported by DOE to other federal programs. The company is now in its second decade of operation and is shifting its focus toward further transfer of its technologies to commercial applications. Among the technologies with origin from the fusion research being developed with significant potential for large scale commercial applications is a process for the growth of single crystal diamond as substrate for electronic devices. Diamond is an attractive electronic material because of the wide bandgap, high electron mobility, high thermal conductivity and high temperature tolerance. Although it has been shown that diamond can be synthesized from the gas phase by plasma assisted chemical vapor deposition (PACVD), the resulting films are polycrystalline due to lack of control on the nucleation process, and such thin films of randomly oriented diamond crystals are used mostly as coatings for their thermal, mechanical and chemical properties but are not suitable for electronic device applications. The regenerative homoepitaxy process the authors have developed for synthesis of single crystal diamond films was derived from the knowledge and capabilities in fusion research in three ways. First, the PACVD reactor was built from knowledge of using microwaves to generate plasmas. Second, the experience to synthesize diamond by the PACVD process was gained from work supported by the fusion program in an attempt to develop a polycrystalline diamond window for high power microwave tubes. Finally, the inspiration for using the PACVD process to obtain single crystal diamond films came from insight gained in studying material damage associated with the first wall of a fusion reactor.

Woo, J.T.

1993-12-01

54

Regenerative Strategies for Craniofacial Disorders  

PubMed Central

Craniofacial disorders present markedly complicated problems in reconstruction because of the complex interactions of the multiple, simultaneously affected tissues. Regenerative medicine holds promise for new strategies to improve treatment of these disorders. This review addresses current areas of unmet need in craniofacial reconstruction and emphasizes how craniofacial tissues differ from their analogs elsewhere in the body. We present a problem-based approach to illustrate current treatment strategies for various craniofacial disorders, to highlight areas of need, and to suggest regenerative strategies for craniofacial bone, fat, muscle, nerve, and skin. For some tissues, current approaches offer excellent reconstructive solutions using autologous tissue or prosthetic materials. Thus, new “regenerative” approaches would need to offer major advantages in order to be adopted. In other tissues, the unmet need is great, and we suggest the greatest regenerative need is for muscle, skin, and nerve. The advent of composite facial tissue transplantation and the development of regenerative medicine are each likely to add important new paradigms to our treatment of craniofacial disorders. PMID:23248598

Garland, Catharine B.; Pomerantz, Jason H.

2012-01-01

55

Regenerative strategies for craniofacial disorders.  

PubMed

Craniofacial disorders present markedly complicated problems in reconstruction because of the complex interactions of the multiple, simultaneously affected tissues. Regenerative medicine holds promise for new strategies to improve treatment of these disorders. This review addresses current areas of unmet need in craniofacial reconstruction and emphasizes how craniofacial tissues differ from their analogs elsewhere in the body. We present a problem-based approach to illustrate current treatment strategies for various craniofacial disorders, to highlight areas of need, and to suggest regenerative strategies for craniofacial bone, fat, muscle, nerve, and skin. For some tissues, current approaches offer excellent reconstructive solutions using autologous tissue or prosthetic materials. Thus, new "regenerative" approaches would need to offer major advantages in order to be adopted. In other tissues, the unmet need is great, and we suggest the greatest regenerative need is for muscle, skin, and nerve. The advent of composite facial tissue transplantation and the development of regenerative medicine are each likely to add important new paradigms to our treatment of craniofacial disorders. PMID:23248598

Garland, Catharine B; Pomerantz, Jason H

2012-01-01

56

The Biology of Regenerative Medicine  

NSDL National Science Digital Library

The goal of regenerative medicine is to restore the structure and function of human body parts compromised by injury or disease. Regenerative medicine is a relatively new field that uses multiple approaches and has its roots largely in tissue engineering, tissue transplantation, and stem cell biology. It is becoming increasingly clear that advances in the areas of regeneration biology and developmental biology have the potential to transform regenerative medicine, and David Stocum has produced a textbook that attempts to pull everything together for the next generation of regeneration scientists. Regeneration Biology and Medicine is a terrific reference for anyone toying with the idea of moving into this field. The text offers an enormous breath of coverage of different systems currently under investigation, and Stocum provides a central theme that pits regenerative ability against fibrosis as a way to conceptually untangle the limited regenerative capacity of humans. In writing this textbook, Stocum has erected an umbrella large enough for scientists of diverse backgrounds to initiate conceptual cross-talk between those actively involved in the biology of regeneration and those targeting its clinical application.

Ken Muneoka (Tulane University; Department of Cell and Molecular Biology REV)

2007-06-05

57

Regeneratively Cooled Porous Media Jacket  

NASA Technical Reports Server (NTRS)

The fluid and heat transfer theory for regenerative cooling of a rocket combustion chamber with a porous media coolant jacket is presented. This model is used to design a regeneratively cooled rocket or other high temperature engine cooling jacket. Cooling jackets comprising impermeable inner and outer walls, and porous media channels are disclosed. Also disclosed are porous media coolant jackets with additional structures designed to transfer heat directly from the inner wall to the outer wall, and structures designed to direct movement of the coolant fluid from the inner wall to the outer wall. Methods of making such jackets are also disclosed.

Mungas, Greg (Inventor); Fisher, David J. (Inventor); London, Adam Pollok (Inventor); Fryer, Jack Merrill (Inventor)

2013-01-01

58

Regenerative Medicine: Learning from Past Examples  

E-print Network

Regenerative medicine products have characteristically shown great therapeutic potential, but limited market success. Learning from the past attempts at capturing value is critical for new and emerging regenerative medicine ...

Couto, Daniela S.

59

European Doctoral Academy in Regenerative Engineering  

E-print Network

and experts in the field of cardiovascular tissue engineering and regenerative medicine, with a view of cardiovascular tissue engineering and regenerative medicine. Each ESR Fellow will perform an individual researchEuropean Doctoral Academy in Regenerative Engineering Marie Curie Initial Training Network TECAS

Cesare, Bernardo

60

Angiolymphoid hyperplasia with follicular mucinosis.  

PubMed

Follicular mucinosis occurring along with angiolymphoid hyperplasia with eosinophils (ALHE) has been described in a 54-year-old female. The patient presented with pruritic erythematous papules on the left frontoparietal scalp. Histopathological examination showed prominent blood vessels in the dermis lined by plump histiocytoid endothelial cells that were surrounded by a dense lymphoid infiltrate with numerous eosinophils; these findings are typical of angiolymphoid hyperplasia with eosinophils. Features of follicular mucinosis were observed in the same section with several hyperplastic follicular infundibula containing pools of mucin in the infundibular epithelium. The concurrent occurrence of these two distinct histopathological patterns in the same biopsy specimen has been described in only three cases to date. PMID:17921619

Joshi, Rajiv

2007-01-01

61

Regenerative Medicine: Past and Present  

Microsoft Academic Search

Novel therapies resulting from regenerative medicine and tissue engineering technology may offer new hope for patients with injuries, end-stage organ failure, degenerative disorders and many other clinical issues. Currently, patients suffering from diseased and injured organs are treated with transplanted organs. However, there is a shortage of donor organs that is worsening yearly as the population ages and new cases

Anthony Atala

2009-01-01

62

Increasing the efficiency regenerative heaters  

Microsoft Academic Search

The main disadvantage of regenerative air heaters (RAH) is reduced gas confinement. As a result, a significant amount of air leaks into the heater and thus increases heat losses. A method has been proposed and tested, where air induction through radial and peripheral seals of the RAH is directed to the suction pipe of the blast fan for recirculation of

A. M. Leonkov; I. S. Mysak; I. A. Kuskov

1980-01-01

63

Phytotherapy for benign prostatic hyperplasia  

Microsoft Academic Search

Phytotherapy has become a more popular treatment option among American men with benign prostatic hyperplasia (BPH). The most\\u000a popular herbal agent is saw palmetto (Serenoa repens), which is derived from the berry of the American dwarf palm tree. Pygeum africanum and beta-sitosterol are also used by many patients with BPH, either alone or in combination with saw palmetto. A significant

Glenn S. Gerber

2002-01-01

64

Angiolymphoid hyperplasia involving large arteries.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder, which most commonly involves the skin of the head and neck regions. Noncutaneous localization of this pathology is unusual, and its primary localization in large arteries presenting as a pulsatile mass is extremely rare. We report here two cases of ALHE manifested as masses of the occipital and brachial artery. ALHE should be considered in the differential diagnosis of localized peripheral arterial masses in young patients. PMID:18455650

Vandy, Frank; Izquierdo, Luis; Liu, Jingxuan; Criado, Enrique

2008-05-01

65

Adenomatous hyperplasia of the liver.  

PubMed

An unusual case of adenomatous hyperplasia of the liver arose spontaneously in an 82-year-old woman. Massive fatal ascites developed during an eight-week period in the absence of cirrhosis. No drug, chemical, or hormone could be identified as the causative agent. Estrogens may play a role as possible promoters in the growth of hepatic tumors. Identifying liver tumors in women that are not associated with oral contraceptive use is valuable. PMID:215102

Gindhart, T D; Cimis, R J; Mosenthal, W T; Longnecker, D S

1979-01-01

66

Electrospun Nanofibers for Regenerative Medicine**  

PubMed Central

This article reviews recent progress in applying electrospun nanofibers to the emerging field of regenerative medicine. We begin with a brief introduction to electrospinning and nanofibers, with a focus on issues related to the selection of materials, incorporation of bioactive molecules, degradation characteristics, control of mechanical properties, and facilitation of cell infiltration. We then discuss a number of approaches to fabrication of scaffolds from electrospun nanofibers, including techniques for controlling the alignment of nanofibers and for producing scaffolds with complex architectures. We also highlight applications of the nanofiber-based scaffolds in four areas of regenerative medicine that involve nerves, dural tissues, tendons, and the tendon-to-bone insertion site. We conclude this review with perspectives on challenges and future directions for design, fabrication, and utilization of scaffolds based on electrospun nanofibers. PMID:23184683

Liu, Wenying; Thomopoulos, Stavros

2013-01-01

67

Heat regenerative external combustion engine  

NASA Astrophysics Data System (ADS)

It is an object of the invention to provide an external combustion expander-type engine having improved efficiency. It is another object of the invention to provide an external combustion engine in which afterburning in the exhaust channel is substantially prevented. Yet another object of the invention is to provide an external combustion engine which is less noisy than an external combustion engine of conventional design. These and other objects of the invention will become more apparent from the following description. The above objects of the invention are realized by providing a heat regenerative external combustion engine. The heat regenerative external combustion engine of the invention comprises a combustion chamber for combusting a monopropellant fuel in order to form an energized gas. The energized gas is then passed through a rotary valve to a cylinder having a reciprocating piston disposed therein. The gas is spent in moving the piston, thereby driving a drive shaft.

Duva, Anthony W.

1993-03-01

68

Nanotechnology Biomimetic Cartilage Regenerative Scaffolds  

PubMed Central

Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an emphasis on the application of nanotechnology in the production of biomimetic cartilage regenerative scaffolds. The structural architecture and composition of the cartilage extracellular matrix and the evolution of tissue engineering concepts and scaffold technology over the last two decades are outlined. Current advances in biomimetic techniques to produce nanoscaled fibrous scaffolds, together with innovative methods to improve scaffold biofunctionality with bioactive cues are highlighted. To date, the majority of research into cartilage regeneration has been focused on articular cartilage due to the high prevalence of large joint osteoarthritis in an increasingly aging population. Nevertheless, the principles and advances are applicable to cartilage engineering for plastic and reconstructive surgery. PMID:24883273

Sardinha, Jose Paulo; Myers, Simon

2014-01-01

69

Regenerative Medicine for the Cornea  

PubMed Central

Regenerative medicine for the cornea provides a novel treatment strategy for patients with corneal diseases instead of conventional keratoplasty. Limbal transplantation has been performed in patients with a limbal stem cell deficiency. This procedure requires long-term immunosuppression that involves high risks of serious eye and systemic complications, including infection, glaucoma, and liver dysfunction. To solve these problems, ocular surface reconstruction using cultured limbal or oral mucosal epithelial stem cells has been successfully applied to patients. However, cell sheets must be fabricated in a cell processing center (CPC) under good manufacturing practice conditions for clinical use, and the expenses of maintaining a CPC are too high for all hospitals to cover. Therefore, several hospitals should share one CPC to standardize and spread the application of regenerative therapy using tissue-engineered oral mucosal epithelial cell sheets. Consequently, we developed a cell transportation technique for clinical trial to bridge hospitals. This paper reviews the current status of regenerative medicine for the cornea. PMID:24396826

Oie, Yoshinori; Nishida, Kohji

2013-01-01

70

Oral verrucous hyperplasia: a case report.  

PubMed

Oral verrucous hyperplasia is a whitish or pinkinsh elevated pre malignant lesion which occurs rarely. Its is also considered to be an early form of verrucous carcinoma. We have reported a case of verrucous hyperplasia which was diagnosed and treated with buccal fat pad as graft. PMID:25018612

Navaneetham, Anuradha; Dayanand Saraswathi, M C; Santosh, B S

2014-09-01

71

Medical management of benign prostatic hyperplasia  

Microsoft Academic Search

The management of benign prostatic hyperplasia has undergone a rapid evolution over the past decade from a surgical emphasis to a medical emphasis. Great strides in the development of a-adrenergic blockers, 5a-reductase inhibitors and a variety of phytotherapeutics have fueled this evolution. This article reviews the past, present and future of the medical management of benign prostatic hyperplasia.

Andrew Chacon; Manoj Monga

1999-01-01

72

Proboscis-like Brunner's gland hyperplasia.  

PubMed

Hyperplasia of Brunner's glands is a benign lesion discovered incidentally in 2% of upper gastrointestinal endoscopies. An asymptomatic 34-year-old woman had a 12-cm duodenal lesion resembling an elephant's proboscis. It was removed surgically and proved to be Brunner's gland hyperplasia. PMID:18585675

Chang, Chen-Wang; Chang, Wen-Hsiung; Shih, Shou-Chuan; Lin, Shee-Chan; Yang, Tsen-Long; Wang, Tsang-En

2008-10-01

73

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE RESEARCH ARTICLE J Tissue Eng Regen Med (2011).  

E-print Network

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE RESEARCH ARTICLE J Tissue Eng Regen Med the principles of engineering, cell biology and medicine. Successfully engineered three-dimensional (3D) cardiac

Linhardt, Robert J.

74

Regenerative Boiler Feedwater Heater Economics  

E-print Network

to generate an increment of power en route to the heater. Heat power cycle efficiency is, thUS, improved. For maximum cycle efficiency, the feedwater temperature on en try to the boi ler wou ld equa 1 the temperature of the boiler water itself. Since th... is to produce more power [r"m constant fuel J or constant power from less fuel. Pressures and temperatures have been driven upward; vaCllum h.~s approached atmospheric limits. MUltiple stages of regenerative feed preheat and steam reheat are normal...

Viar, W. L.

75

Wavelength tunable alexandrite regenerative amplifier  

SciTech Connect

We describe a wavelength tunable alexandrite regenerative amplifier which is used to amplify nanosecond slices from a single-frequency cw dye laser or 50-ps pulses emitted by a diode laser to energies in the 10-mJ range. The amplified 5-ns slices generated by the cw-pumped line narrowed dye laser are Fourier transform limited. The 50-ps pulses emitted by a gain-switched diode laser are amplified by more than 10 orders of magnitude in a single stage.

Harter, D.J.; Bado, P.

1988-11-01

76

Entropy Generation in Regenerative Systems  

NASA Technical Reports Server (NTRS)

Heat exchange to the oscillating flows in regenerative coolers generates entropy. These flows are characterized by oscillating mass flows and oscillating temperatures. Heat is transferred between the flow and heat exchangers and regenerators. In the former case, there is a steady temperature difference between the flow and the heat exchangers. In the latter case, there is no mean temperature difference. In this paper a mathematical model of the entropy generated is developed for both cases. Estimates of the entropy generated by this process are given for oscillating flows in heat exchangers and in regenerators. The practical significance of this entropy is also discussed.

Kittel, Peter

1995-01-01

77

Heat regenerative external combustion engine  

NASA Astrophysics Data System (ADS)

A heat regenerative external combustion engine is disclosed. The engine includes fuel inlet means which extends along the exhaust passage and/or combustion chamber in order to preheat the fuel, To provide for preheating by gases in both the combustion chamber and the exhaust passage, the combustion chamber is arranged annularly around the drive shaft and between the cylinders. This configuration also is advantageous in that it reduces the noise of combustion. The engine of the invention is particularly well-suited for use in a torpedo.

Duva, Anthony W.

1993-10-01

78

Tenure Track Assistant Professor Cluster Hire in Regenerative Medicine  

E-print Network

Tenure Track Assistant Professor Cluster Hire in Regenerative Medicine The Departments of regenerative medicine, including the genetic and epigenetic control of embryonic, adult, or cancer stem cells organisms to explore fundamental and translational questions in regenerative medicine. We anticipate

Stormo, Gary

79

Cutaneous vascular proliferations. Part II. Hyperplasias and benign neoplasms  

Microsoft Academic Search

This second part of our review about vascular proliferations summarizes the clinicopathologic features of the cutaneous vascular hyperplasias and benign neoplasms. Hyperplasias comprise a heterogeneous group of vascular proliferations that eventually show a tendency to regression. Angiolymphoid hyperplasia with eosinophilia is included within the group of hyperplasias because of its historical denomination and its reactive nature, probably as a consequence

Luis Requena; Omar P. Sangueza

1997-01-01

80

Congenital adrenal hyperplasia and pregnancy.  

PubMed

A 32-year-old woman with classical congenital adrenal hyperplasia (CAH) secondary to 21-hydroxylase deficiency presented with infertility. She was treated with different steroid replacement regimens together with fludrocortisone. The aim of this case report is to discuss fertility barriers in women with classical CAH, and emphasise the risks and benefits of available steroid treatment options. Clinical considerations covered include preconception health and fertility planning, optimising fertility through suppression of excess hormone production, reducing fetal androgen exposure in utero and limiting maternal and fetal side effects of therapy and limiting chances of CAH in the baby. In this case suppression of androgen and progesterone levels was challenging but eventually was achieved and resulted in a spontaneous pregnancy. However, she miscarried in the first trimester, and fetal biopsy revealed a complete hydatiform mole. She is advised not to conceive while she is under investigation to determine the extent of the disease. PMID:23917362

Shorakae, Soulmaz; Teede, Helena

2013-01-01

81

[Treatment of benign prostatic hyperplasia].  

PubMed

Due to innovative pharmacological and endoscopic/interventional concepts of therapy, the strategies of facing the benign prostatic hyperplasia have undergone a significant diversification within the last ten years. In addition to phytotherapeutic drugs, which have been in clinical use for decades, alpha receptor blockers and blockers of DHT-synthesis have gained increasing importance. More or less convincing instrumental competing methods have been developed as an alternative to the transurethral resection of the prostate or the transvesical prostatectomy. Regarding the altered age pyramid structure and decreasing financial means, guidelines for the diagnosis and therapy of the BPH-syndrome are consequently being developed in order to support the establishment of an individual therapy of BPH, to increase the efficacy of therapy and to be able to get along with the existing financial barriers. The development of the International Prostate Symptoms Score (IPSS) is regarded essential for this effort. PMID:9702820

Harzmann, R; Weckermann, D; Wawroschek, F

1998-06-01

82

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE RESEARCH ARTICLE J Tissue Eng Regen Med 2012;6: 135143.  

E-print Network

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE RESEARCH ARTICLE J Tissue Eng Regen Med and Regenerative Medicine 4 METU, BIOMATEN Center of Excellence in Biomaterials and Tissue Engineering, Ankara

Hasýrcý, Vasýf

83

Combined hydraulic and regenerative braking system  

Microsoft Academic Search

A combined hydraulic and regenerative braking system and method for an electric vehicle, with the braking system being responsive to the applied hydraulic pressure in a brake line to control the braking of the vehicle to be completely hydraulic up to a first level of brake line pressure, to be partially hydraulic at a constant braking force and partially regenerative

Rama R. Venkataperumal; Gerald E. Mericle

1981-01-01

84

Dissecting the mechanisms of Notch induced hyperplasia  

PubMed Central

The outcome of the Notch pathway on proliferation depends on cellular context, being growth promotion in some, including several cancers, and growth inhibition in others. Such disparate outcomes are evident in Drosophila wing discs, where Notch overactivation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms, we have used genomic strategies to identify the Notch-CSL target genes directly activated during wing disc hyperplasia. Among them were genes involved in both autonomous and non-autonomous regulation of proliferation, growth and cell death, providing molecular explanations for many characteristics of Notch induced wing disc hyperplasia previously reported. The Notch targets exhibit different response patterns, which are shaped by both positive and negative feed-forward regulation between the Notch targets themselves. We propose, therefore, that both the characteristics of the direct Notch targets and their cross-regulatory relationships are important in coordinating the pattern of hyperplasia. PMID:23232763

Djiane, Alexandre; Krejci, Alena; Bernard, Frédéric; Fexova, Silvie; Millen, Katherine; Bray, Sarah J

2013-01-01

85

Sebaceous hyperplasia: systemic treatment with isotretinoin*  

PubMed Central

The study aimed to verify the therapeutic action of isotretinoin in the treatment of sebaceous hyperplasia. During two months, 20 patients with sebaceous hyperplasia took isotretinoin at a dosage of 1mg/kg per day. Their skin lesions were counted and photographed before and after treatment and re-evaluated two years later. The average number of sebaceous hyperplasia lesions before treatment was 24 per patient. At the end of two months of therapy, the number of lesions decreased to 2 per patient. The statistically analyzed data showed a reduction in the number of lesions following isotretinoin use (p < 0.05). Two years after the end of the treatment, the average number of sebaceous hyperplasia lesions was 4 per patient. There were no severe side effects. Thus, the data analysis suggests that isotretinoin is a safe and effective drug for treating the disease under study.

Tagliolatto, Sandra; Santos, Octavio de Oliveira; Alchorne, Maurício Mota de Avelar; Enokihara, Mauro Yoshiaki

2015-01-01

86

Ancient history of congenital adrenal hyperplasia.  

PubMed

Although there are many erudite reports on the history of endocrinology and endocrine disorders, the history of congenital adrenal hyperplasia has not been published. I have tried to review ancient as well as modern history of CAH. PMID:21164274

New, Maria I

2011-01-01

87

Gingival enlargement in partial hemifacial hyperplasia  

PubMed Central

Hemifacial hypertrophy is a rare developmental disorder, characterized by unilateral enlargement of facial tissues. The hemifacial hyperplasia is classified as true hemifacial hypertrophy and partial hemifacial hypertrophy. It is unilateral enlargement of viscerocranial condition in which not all structures are enlarged. We present a rare case of gingival enlargement in partial hemifacial hyperplasia highlighting the clinical and radiological findings with the corrective treatment offered for gingival enlargement. PMID:25624636

Jagtap, Rasika Ravindra; Deshpande, Gaurav Shekhar

2014-01-01

88

Macronodular adrenocortical hyperplasia in a postmenopausal woman.  

PubMed

This case report describes the diagnosis of Cushing's syndrome due to macronodular adrenal hyperplasia in an elderly woman who presented with fatigue, muscle weakness and oedema, and recent excessive bruising. Long-standing disease and comorbidity precluded adrenalectomy. Despite treatment with metyrapone and diuretics, the patient died after two months hospitalisation. Postmortal examination revealed overexpression of luteinising hormone (LH) receptors in the adrenal glands, suggesting that the postmenopausal rise in LH may have a role in adrenal hyperplasia and hypercortisolism. PMID:15685897

Mijnhout, G S; Danner, S A; van de Goot, F R W; van Dam, E W C M

2004-12-01

89

Management of adolescents with congenital adrenal hyperplasia  

PubMed Central

The management of congenital adrenal hyperplasia involves suppression of adrenal androgen production, in addition to treatment of adrenal insufficiency. Management of adolescents with congenital adrenal hyperplasia is especially challenging because changes in the hormonal milieu during puberty can lead to inadequate suppression of adrenal androgens, psychosocial issues often affect adherence to medical therapy, and sexual function plays a major part in adolescence and young adulthood. For these reasons, treatment regimen reassessment is indicated during adolescence. Patients with non-classic congenital adrenal hyperplasia require reassessment regarding the need for glucocorticoid drug treatment. No clinical trials have compared various regimens for classic congenital adrenal hyperplasia in adults, thus therapy is individualised and based on the prevention of adverse outcomes. Extensive patient education is key during transition from paediatric care to adult care and should include education of females with classic congenital adrenal hyperplasia regarding their genital anatomy and surgical history. Common issues for these patients include urinary incontinence, vaginal stenosis, clitoral pain, and cosmetic concerns; for males with classic congenital adrenal hyperplasia, common issues include testicular adrenal rest tumours. Transition from paediatric to adult care is most successful when phased over many years. Education of health-care providers on how to successfully transition patients is greatly needed. PMID:24622419

Merke, Deborah P; Poppas, Dix P

2014-01-01

90

Variable ratio regenerative braking device  

DOEpatents

Disclosed is a regenerative braking device (10) for an automotive vehicle. The device includes an energy storage assembly (12) having a plurality of rubber rollers (26, 28) mounted for rotation between an input shaft (36) and an output shaft (42), clutches (38, 46) and brakes (40, 48) associated with each shaft, and a continuously variable transmission (22) connectable to a vehicle drivetrain and to the input and output shafts by the respective clutches. The rubber rollers are torsionally stressed to accumulate energy from the vehicle when the input shaft is clutched to the transmission while the brake on the output shaft is applied, and are torsionally relaxed to deliver energy to the vehicle when the output shaft is clutched to the transmission while the brake on the input shaft is applied. The transmission ratio is varied to control the rate of energy accumulation and delivery for a given rotational speed of the vehicle drivetrain.

Hoppie, Lyle O. (Birmingham, MI)

1981-12-15

91

Unitized regenerative fuel cell system  

NASA Technical Reports Server (NTRS)

A Unitized Regenerative Fuel Cell system uses heat pipes to convey waste heat from the fuel cell stack to the reactant storage tanks. The storage tanks act as heat sinks/sources and as passive radiators of the waste heat from the fuel cell stack. During charge up, i.e., the electrolytic process, gases are conveyed to the reactant storage tanks by way of tubes that include dryers. Reactant gases moving through the dryers give up energy to the cold tanks, causing water vapor in with the gases to condense and freeze on the internal surfaces of the dryer. During operation in its fuel cell mode, the heat pipes convey waste heat from the fuel cell stack to the respective reactant storage tanks, thereby heating them such that the reactant gases, as they pass though the respective dryers on their way to the fuel cell stacks retrieve the water previously removed.

Burke, Kenneth A. (Inventor)

2008-01-01

92

Unitized regenerative fuel cell systems  

SciTech Connect

Energy storage systems with extremely high specific energy (>400 Wh/kg) have been designed that use lightweight pressure vessels to contain the gases generated by reversible (unitized) regenerative fuel cells (URFCs).[1] URFC systems are being designed and developed for a variety of applications, including high altitude long endurance (HALE) solar rechargeable aircraft (SRA), zero emission vehicles (ZEVs), hybrid energy storage/propulsion systems for spacecraft, energy storage for remote (off-grid) power sources, and peak shaving for on-grid applications.[1-10] Energy storage for HALE SRA was the original application for this set of innovations, and a prototype solar powered aircraft (Pathfinder-Plus) recently set another altitude record for all propeller-driven aircraft on August 6, 1998, when it flew to 80,285 feet (24.47 km).[11

Mitlitsky, F; Molter, T M; Myers, B; Weisberg, A H

1998-09-10

93

Perivascular cells for regenerative medicine  

PubMed Central

Mesenchymal stem/stromal cells (MSC) are currently the best candidate therapeutic cells for regenerative medicine related to osteoarticular, muscular, vascular and inflammatory diseases, although these cells remain heterogeneous and necessitate a better biological characterization. We and others recently described that MSC originate from two types of perivascular cells, namely pericytes and adventitial cells and contain the in situ counterpart of MSC in developing and adult human organs, which can be prospectively purified using well defined cell surface markers. Pericytes encircle endothelial cells of capillaries and microvessels and express the adhesion molecule CD146 and the PDGFR?, but lack endothelial and haematopoietic markers such as CD34, CD31, vWF (von Willebrand factor), the ligand for Ulex europaeus 1 (UEA1) and CD45 respectively. The proteoglycan NG2 is a pericyte marker exclusively associated with the arterial system. Besides its expression in smooth muscle cells, smooth muscle actin (?SMA) is also detected in subsets of pericytes. Adventitial cells surround the largest vessels and, opposite to pericytes, are not closely associated to endothelial cells. Adventitial cells express CD34 and lack ?SMA and all endothelial and haematopoietic cell markers, as for pericytes. Altogether, pericytes and adventitial perivascular cells express in situ and in culture markers of MSC and display capacities to differentiate towards osteogenic, adipogenic and chondrogenic cell lineages. Importantly, adventitial cells can differentiate into pericyte-like cells under inductive conditions in vitro. Altogether, using purified perivascular cells instead of MSC may bring higher benefits to regenerative medicine, including the possibility, for the first time, to use these cells uncultured. PMID:22882758

Crisan, Mihaela; Corselli, Mirko; Chen, William CW; Péault, Bruno; Moldovan, NI

2012-01-01

94

Regenerative braking system for a hybrid electric vehicle  

Microsoft Academic Search

This paper discusses a regenerative braking system (RBS) for a parallel hybrid electric vehicle (PHEV) that performs regenerative energy recovery based on vehicle attributes, thereby providing improved performance, efficiency and reliability at minimal additional cost. A detailed description of the regenerative braking algorithm is presented along with simulation results from a dynamic model of the PHEV exhibiting the regenerative braking

S. R. Cikanek; K. E. Bailey

2002-01-01

95

Harmonic retrieval of regenerative machining chatter responses  

NASA Astrophysics Data System (ADS)

Based on cross fourth-order cumulants, a total least square ESPRIT approach to jointly estimating harmonic parameters in hybrid colored noises is presented, which is applied to investigate the harmonic retrieval of regenerative machining chatter responses. Taking into consideration the multiple-regenerative effect, the delayed machining dynamics under the excitation of stochastic noises is modeled, and a recursive algorithm of the solution to the delayed machining dynamics is proposed. The harmonic parameter estimation of regenerative chatter responses is detailed, which include the harmonic frequencies, cross powers, and phase shifts between successive cuts. The results demonstrate that the presented harmonic parameter estimation approach can eliminate the hybrid colored noises, retrieve the harmonic parameters with excellent estimation performance, and extract the evolution features of regenerative machining chatter.

Zhou, Xiaoqin; Wang, Wencai; Lin, Jieqiong

2013-12-01

96

Sources of Stem Cells for Regenerative Medicine  

Microsoft Academic Search

The shortage of organ donors for regenerative medicine has stimulated research on stem cells as a potential resource for cell-based\\u000a therapy. Stem cells have been used widely for regenerative medicine applications. The development of innovative methods to\\u000a generate stem cells from different sources suggests that there may be new alternatives for cell-based therapies. Here, we\\u000a provide an overview of human

Jennifer Hipp; Anthony Atala

2008-01-01

97

Current overview on challenges in regenerative endodontics  

PubMed Central

Introduction: Regenerative endodontics provides hope of converting the non-vital tooth into vital once again. It focuses on substituting traumatized and pathological pulp with functional pulp tissue. Current regenerative procedures successfully produce root development but still fail to re-establish real pulp tissue and give unpredictable results. There are several drawbacks that need to be addressed to improve the quality and efficiency of the treatment. Aim: The aim of this review article is to discuss major priorities that ought to be dealt before applications of regenerative endodontics flourish the clinical practice. Materials and Methods: A web-based research on MEDLINE was done using filter terms Review, published in the last 10 years and Dental journals. Keywords used for research were “regenerative endodontics,” “dental stem cells,” “growth factor regeneration,” “scaffolds,” and “challenges in regeneration.” This review article screened about 150 articles and then the relevant information was compiled. Results: Inspite of the impressive growth in regenerative endodontic field, there are certain loopholes in the existing treatment protocols that might sometimes result in undesired and unpredictable outcomes. Conclusion: Considerable research and development efforts are required to improve and update existing regenerative endodontic strategies to make it an effective, safe, and biological mode to save teeth. PMID:25657518

Bansal, Ramta; Jain, Aditya; Mittal, Sunandan

2015-01-01

98

High power regenerative laser amplifier  

DOEpatents

A regenerative amplifier design capable of operating at high energy per pulse, for instance, from 20-100 Joules, at moderate repetition rates, for instance from 5-20 Hertz is provided. The laser amplifier comprises a gain medium and source of pump energy coupled with the gain medium; a Pockels cell, which rotates an incident beam in response to application of a control signal; an optical relay system defining a first relay plane near the gain medium and a second relay plane near the rotator; and a plurality of reflectors configured to define an optical path through the gain medium, optical relay and Pockels cell, such that each transit of the optical path includes at least one pass through the gain medium and only one pass through the Pockels cell. An input coupler, and an output coupler are provided, implemented by a single polarizer. A control circuit coupled to the Pockels cell generates the control signal in timed relationship with the input pulse so that the input pulse is captured by the input coupler and proceeds through at least one transit of the optical path, and then the control signal is applied to cause rotation of the pulse to a polarization reflected by the polarizer, after which the captured pulse passes through the gain medium at least once more and is reflected out of the optical path by the polarizer before passing through the rotator again to provide an amplified pulse. 7 figures.

Miller, J.L.; Hackel, L.A.; Dane, C.B.; Zapata, L.E.

1994-02-08

99

High power regenerative laser amplifier  

DOEpatents

A regenerative amplifier design capable of operating at high energy per pulse, for instance, from 20-100 Joules, at moderate repetition rates, for instance from 5-20 Hertz is provided. The laser amplifier comprises a gain medium and source of pump energy coupled with the gain medium; a Pockels cell, which rotates an incident beam in response to application of a control signal; an optical relay system defining a first relay plane near the gain medium and a second relay plane near the rotator; and a plurality of reflectors configured to define an optical path through the gain medium, optical relay and Pockels cell, such that each transit of the optical path includes at least one pass through the gain medium and only one pass through the Pockels cell. An input coupler, and an output coupler are provided, implemented by a single polarizer. A control circuit coupled to the Pockels cell generates the control signal in timed relationship with the input pulse so that the input pulse is captured by the input coupler and proceeds through at least one transit of the optical path, and then the control signal is applied to cause rotation of the pulse to a polarization reflected by the polarizer, after which the captured pulse passes through the gain medium at least once more and is reflected out of the optical path by the polarizer before passing through the rotator again to provide an amplified pulse.

Miller, John L. (Livermore, CA); Hackel, Lloyd A. (Livermore, CA); Dane, Clifford B. (Dublin, CA); Zapata, Luis E. (Livermore, CA)

1994-01-01

100

Regenerative rotary displacer Stirling engine  

SciTech Connect

A few rotary displacer Stirling engines in which the displacer has one gas pocket space at one side and rotates in a main enclosed cylinder, which is heated from one side and cooled from opposite side without any regenerator, have been studied for some time by the authors. The authors tried to improve this engine by equipping it with a regenerator, because without a regenerator, pressure oscillation and efficiency are too small. Here, several types of regenerative rotary displacer piston Stirling engines are proposed. One is the contra-rotating tandem two disc type displacer engine using axial heat conduction through side walls or by heat pipes and another is a single disc type with circulating fluid regenerator or heat pipes. Stirling engines of this new rotary displacer type are thought to attain high speed. Here, experimental results of the original rotary displacer Stirling engine without a regenerator, and one contra-rotating tandem displacer engine with side wall regenerator by axial heat conduction are reported accompanied with a discussion of the results.

Isshiki, Naotsugu; Watanabe, Hiroichi [Nihon Univ. Tokyo (Japan); Raggi, L. [Waseda Univ., Tokyo (Japan); Isshiki, Seita; Hirata, Koichi

1996-12-31

101

Intractable verrucous hyperplasia: a surgically corrected case.  

PubMed

Skin problems commonly occur after lower limb amputation. One such skin anomaly that develops on the residual limb is wart-like lesions of verrucous hyperplasia. The process is reversible if external compression is applied in combination with adequate control of bacterial infection and edema. Prosthetic adjustments usually help with this condition. We report an intractable verrucous hyperplasia in a 66-year-old female patient. She complained of a painful, oozing, verrucous papule at the amputation site. Despite management with typical treatment procedures, the lesion worsened; therefore, surgery was performed. Our case demonstrates that an intractable case is possible despite appropriate management and that sometimes surgical correction is necessary. PMID:25479281

Chang, Ji Hea; Moon, Hee Bong; Kim, Chang Jae; Nam, Kiyeun; Lee, Ho Jun; Kwon, Bum Sun; Park, Jin-Woo

2015-03-01

102

Stem cells: a regenerative pharmaceutical.  

PubMed

Stem cells (SC), found in both adult and fetal tissues, are self-renewing elements that can generate the various cell types in the body. There are 3 classes of SC: totipotent, multipotent, and pluripotent. The SC with a significant developmental potential are the embryonic stem (ES) cells, which are derived from the early stages of mammalian embryo. SC possess regenerative properties and this offers unprecedented opportunities for developing medical therapies for debilitating diseases. Hematopoietic SC have been used successfully in bone marrow transplants for over 40 years. Pluripotent SC offer renewable source of replacement of cells and tissues to treat a myriad of diseases. However there are limiting factors. Adult SC are rare and cannot multiply as the ES. Pluripotent SC have great therapeutic potential, but face technical challenges. A serious concern is the ethical issue since they are derived from human embryos or fetal tissue. Quite often SC have been targets of mutations and risk carcinogenesis. Various markers have been identified based on the uniqueness of SC receptors and in vivo tracking studies using nanocolloids and radioactive tracers have been performed. Though 111In-oxine has been used to image SC transplants, PET with a high spatial resolution would be ideal. Currently 2 agents are being studied, 18F-FDG and 64Cu-Pyruvaldehyde bi(N4-methylthiosemicarbazone). The following few pages bring forth the various limitations and summarize progress made in SC utilization so as to create awareness of SC research in ISORBE community and to foster strategy that ISORBE community can disseminate information and exchange knowledge on radio labeled SC. PMID:16868534

Shanthly, N; Aruva, M R; Zhang, K; Mathew, B; Thakur, M L

2006-09-01

103

Advances in understanding tissue regenerative capacity and mechanisms in animals  

PubMed Central

Questions about how and why tissue regeneration occurs capture the attention of countless biologists, biomedical engineers, and clinicians. Regenerative capacity differs greatly across organs and organisms, and a spectrum of model systems with different technical advantages and regenerative strategies are studied. Several key issues common to natural regenerative events are receiving new attention from improving models and approaches, including: the determination of regenerative capacity; the importance of stem cells, dedifferentation and transdifferentiation; how regenerative signals are initiated and targeted; and the mechanisms that control regenerative proliferation and patterning. PMID:20838411

Poss, Kenneth D.

2011-01-01

104

Angiolymphoid hyperplasia with eosinophilia - A case report.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a distinctive vascular tumor presenting as isolated or grouped papules or plaques or nodules over skin in head and neck. We, hereby, present a case of ALHE affecting the base of tongue-a rare site of involvement. PMID:23120317

Jacob, Joe; George, Shibu; Suchit Roy, B R; Dildeepa, S N

2006-07-01

105

Angiolymphoid hyperplasia with eosbvophilia-case report.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign condition characterized by subcutaneous lesions in the head-neck region. It is frequently misdiagnosed as a malignant lesion. Knowledge of the existence of the disease and pathological interpretation are requisites for early diagnosis. We present a case report and review of the literature. PMID:23119661

Mankekar, G; Chainani, G N; Bhatt, C; Sha, T M

2000-04-01

106

Bacillary angiomatosis associated with pseudoepitheliomatous hyperplasia.  

PubMed

Bacillary angiomatosis is an opportunistic bacterial infection caused by either Bartonella henselae or B. quintana. The classic histologic presentation of bacillary angiomatosis involves three components: a lobular proliferation of capillaries with enlarged endothelial cells, neutrophilic debris, and clumps of finely granular material identified as bacteria with staining techniques. Pseudoepitheliomatous hyperplasia is a histologic reaction pattern characterized by epithelial proliferation in response to a variety of stimuli, including mycobacterial, fungal, and bacterial infections. We describe a case of bacillary angiomatosis associated with pseudoepitheliomatous hyperplasia in an immunocompromised patient with Acquired Immunodeficiency Syndrome. Histologic examination of a finger lesion demonstrated a capillary proliferation with neutrophilic debris and characteristic amorphous granular deposits. Warthin-Starry and Giemsa staining revealed clumps of coccobacilli. Cervical lymph node tissue also revealed organisms identified as Bartonella with PCR techniques. Stains and cultures for acid fast bacilli, fungus, and bacteria were negative. To our knowledge, there has been only one other report of bacillary angiomatosis presenting with pseudoepitheliomatous hyperplasia. We conclude that the differential diagnosis of entities associated with pseudoepitheliomatous hyperplasia should be expanded to include bacillary angiomatosis. PMID:16456322

Amsbaugh, Sean; Huiras, Erin; Wang, Nadia S; Wever, Aaron; Warren, Simon

2006-02-01

107

Combined hydraulic and regenerative braking system  

DOEpatents

A combined hydraulic and regenerative braking system and method for an electric vehicle, with the braking system being responsive to the applied hydraulic pressure in a brake line to control the braking of the vehicle to be completely hydraulic up to a first level of brake line pressure, to be partially hydraulic at a constant braking force and partially regenerative at a linearly increasing braking force from the first level of applied brake line pressure to a higher second level of brake line pressure, to be partially hydraulic at a linearly increasing braking force and partially regenerative at a linearly decreasing braking force from the second level of applied line pressure to a third and higher level of applied line pressure, and to be completely hydraulic at a linearly increasing braking force from the third level to all higher applied levels of line pressure.

Venkataperumal, Rama R. (Troy, MI); Mericle, Gerald E. (Mount Clemens, MI)

1981-06-02

108

Therapeutic potential of nanoceria in regenerative medicine.  

SciTech Connect

Tissue engineering and regenerative medicine aim to achieve functional restoration of tissue or cells damaged through disease, aging or trauma. Advancement of tissue engineering requires innovation in the field of 3D scaffolding, and functionalization with bioactive molecules. Nanotechnology offers advanced materials with patterned nano-morphologies for cell growth and different molecular substrates which can support cell survival and functions. Cerium oxide nanoparticles (nanoceria) can control intracellular as well as extracellular reactive oxygen and nitrogen species. Recent findings suggest that nanoceria can enhance long-term cell survival, enable cell migration and proliferation, and promote stem cell differentiation. Moreover, the self-regenerative property of nanoceria permits a small dose to remain catalytically active for extended time. This review summarizes the possibilities and applications of nanoceria in the field of tissue engineering and regenerative medicine.

Das, Soumen; Chigurupati, Srinivasulu; Dowding, Janet; Munusamy, Prabhakaran; Baer, Donald R.; McGinnis, James F.; Mattson, Mark P.; Self, William; Seal, Sudipta

2014-11-14

109

European Doctoral Academy in Regenerative Engineering Marie Curie Initial Training Network  

E-print Network

) and Regenerative Medicine (RM) though the establishment of a European Doctoral Academy in Regenerative Engineering/cell combinations. Research Field: Cardiovascular tissue engineering and regenerative medicine KeywordsEuropean Doctoral Academy in Regenerative Engineering Marie Curie Initial Training Network TECAS

Cesare, Bernardo

110

Functionalized Nanostructures with Application in Regenerative Medicine  

PubMed Central

In the last decade, both regenerative medicine and nanotechnology have been broadly developed leading important advances in biomedical research as well as in clinical practice. The manipulation on the molecular level and the use of several functionalized nanoscaled materials has application in various fields of regenerative medicine including tissue engineering, cell therapy, diagnosis and drug and gene delivery. The themes covered in this review include nanoparticle systems for tracking transplanted stem cells, self-assembling peptides, nanoparticles for gene delivery into stem cells and biomimetic scaffolds useful for 2D and 3D tissue cell cultures, transplantation and clinical application. PMID:22489186

Perán, Macarena; García, María A.; López-Ruiz, Elena; Bustamante, Milán; Jiménez, Gema; Madeddu, Roberto; Marchal, Juan A.

2012-01-01

111

Cell sheets engineering for esophageal regenerative medicine  

PubMed Central

Recently, cell-based therapies, regenerative medicine, and tissue engineering have been progressing rapidly. We have developed a novel strategy for regenerative medicine to recover tissue functions using temperature-responsive cell culture surfaces. To overcome of conventional methods such as the usage of single-cell suspension injection, we have applied transplantable cell sheets fabricated with temperature-responsive culture surfaces for cell delivery. In the field of gastroenterology, transplantable cell sheets from autologous oral mucosal epithelial cells can prevent esophageal stricture following extensive endoscopic mucosal resection. PMID:25333004

Kanai, Nobuo; Yamato, Masayuki

2014-01-01

112

Improved Regenerative Sorbent-Compressor Refrigerator  

NASA Technical Reports Server (NTRS)

Conceptual regenerative sorbent-compressor refrigerator attains regeneration efficiency and, therefore, overall power efficiency and performance greater than conventional refrigerators. Includes two fluid loops. In one, CH2FCF3 (R134a) ciculates by physical adsorption and desorption in four activated-charcoal sorption compressors. In other, liquid or gas coolant circulated by pump. Wave of regenerative heating and cooling propagates cyclically like peristatic wave among sorption compressors and associated heat exchangers. Powered by electricity, oil, gas, solar heat, or waste heat. Used as air conditioners, refrigerators, and heat pumps in industrial, home, and automotive applications.

Jones, Jack A.

1992-01-01

113

Bone Marrow Mesenchymal Stem Cell Niches and Regenerative Medicine  

E-print Network

1 Bone Marrow Mesenchymal Stem Cell Niches and Regenerative Medicine Inauguraldissertation zur are a powerful tool in regenerative medicine, but suffer from a rapid loss of differentiation potential during

Amrhein, Valentin

114

The mission of the UW Stem Cell and Regenerative Medi-  

E-print Network

the science of stem cell biology and foster breakthroughs in regenerative medicine through faculty Wilmut, Director of the Edinburgh University Regenerative Medicine Centre, helped launch the center related to stem cells and regenerative medicine on campus. The center was started jointly under

115

The mission of the UW Stem Cell and Regenerative Medi-  

E-print Network

the science of stem cell biology and foster breakthroughs in regenerative medicine through faculty to help foster stem cell and regenerative medicine research and education. Change is a constant in lifeSCRMCNotes The mission of the UW Stem Cell and Regenerative Medi- cine Center is to advance

116

The mission of the UW Stem Cell and Regenerative Medi-  

E-print Network

the science of stem cell biology and foster breakthroughs in regenerative medicine through faculty of stem cells and regenerative medicine continues to grow, but so do the challenges to reach the nextSCRMCNotes The mission of the UW Stem Cell and Regenerative Medi- cine Center is to advance

117

*http://nist.gov/mml/polymers/biomaterials/functional_imaging_regenerative_medicine_workshop. ANNOUNCING Functional Imaging for Regenerative Medicine  

E-print Network

*http://nist.gov/mml/polymers/biomaterials/functional_imaging_regenerative_medicine_workshop. cfm ANNOUNCING ­ Functional Imaging for Regenerative Medicine A workshop to be held in Gaithersburg, MD on 31 May

Adams, Mark

118

New Regenerative Cycle for Vapor Compression Refrigeration  

Microsoft Academic Search

The main objective of this project is to confirm on a well-instrumented prototype the theoretically derived claims of higher efficiency and coefficient of performance for geothermal heat pumps based on a new regenerative thermodynamic cycle as comparing to existing technology. In order to demonstrate the improved performance of the prototype, it will be compared to published parameters of commercially available

Mark J. Bergander

2005-01-01

119

Regenerative nanomedicine: current perspectives and future directions  

PubMed Central

Nanotechnology has considerably accelerated the growth of regenerative medicine in recent years. Application of nanotechnology in regenerative medicine has revolutionized the designing of grafts and scaffolds which has resulted in new grafts/scaffold systems having significantly enhanced cellular and tissue regenerative properties. Since the cell–cell and cell-matrix interaction in biological systems takes place at the nanoscale level, the application of nanotechnology gives an edge in modifying the cellular function and/or matrix function in a more desired way to mimic the native tissue/organ. In this review, we focus on the nanotechnology-based recent advances and trends in regenerative medicine and discussed under individual organ systems including bone, cartilage, nerve, skin, teeth, myocardium, liver and eye. Recent studies that are related to the design of various types of nanostructured scaffolds and incorporation of nanomaterials into the matrices are reported. We have also documented reports where these materials and matrices have been compared for their better biocompatibility and efficacy in supporting the damaged tissue. In addition to the recent developments, future directions and possible challenges in translating the findings from bench to bedside are outlined. PMID:25214780

Chaudhury, Koel; Kumar, Vishu; Kandasamy, Jayaprakash; RoyChoudhury, Sourav

2014-01-01

120

Feasibility investigation of allogeneic endometrial regenerative cells  

Microsoft Academic Search

Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like stem cells having pluripotent differentiation activity and ability to induce neoangiogenesis. In vitro and animal studies suggest ERC are immune privileged and in certain situations actively suppress ongoing immune responses. In this paper we describe the production of clinical grade ERC and initial safety experiences in 4 patients with multiple sclerosis

Zhaohui Zhong; Amit N. Patel; Thomas E. Ichim; Neil H. Riordan; Hao Wang; Wei-Ping Min; Erik J. Woods; Michael Reid; Eduardo Mansilla; Gustavo H. Marin; Hugo Drago; Michael P. Murphy; Boris Minev

2009-01-01

121

Combined hydraulic and regenerative braking system  

Microsoft Academic Search

A combined hydraulic and regenerative braking system and method for an electric vehicle is disclosed. The braking system is responsive to the applied hydraulic pressure in a brake line to control the braking of the vehicle to be completely hydraulic up to a first level of brake line pressure, to be partially hydraulic at a constant braking force and partially

R. R. Venkataperumal; G. E. Mericle

1979-01-01

122

Combined hydraulic and regenerative braking system  

Microsoft Academic Search

A combined hydraulic and regenerative braking system and method is disclosed for an electric vehicle. The braking system being responsive to the applied hydraulic pressure in a brake line to control the braking of the vehicle to be completely hydraulic up to a first level of brake line pressure, to be partially hydraulic at a constant braking force and partially

G. E. Mericle; R. R. Venkataperumal

1981-01-01

123

Regenerative Studies: College Community and Community College.  

ERIC Educational Resources Information Center

This case study applies principles derived from the Center for Regenerative Studies (CRS) to a community college in North Carolina. CRS, on the campus of California State Polytechnic Institute (California), is dedicated to the education, demonstration, and research of degenerative systems in the areas of shelter, food production, energy, water and…

Woltz, Mary G.

124

Regenerative process in life and mind.  

PubMed

The functional organization of the nervous system is discussed from the standpoint of organizational closure and regenerative process in order to draw parallels between life and mind. Living organization entails continual regeneration of material parts and functional relations (self-production). Similarly, dynamic stability of informational states in brains may entail coherent self-regenerating patterns of neural signals. If mind is the functional organization of the nervous system, then mental states can be seen as switchings between alternative sets of stable, self-regenerative neural signal productions. In networks of neurons, signaling resonances can be created through recurrent, reentrant neural circuits that are organized to implement a heterarchy of correlational operations. Neural representations are dynamically built-up through an interplay between externally-impressed, incoming sensory signals and internally-generated circulating signals to form pattern-resonances. Semiotic aspects of resonance states involve semantic sensori-motor linkages to and through the external environment and pragmatic linkages to evaluative mechanisms that implement internal goal states. It is hypothesized that coherent regenerative signaling may be an organizational requirement for a material system to support conscious awareness. In this view general anesthetics and seizures abolish awareness by temporarily disrupting the organizational coherence of regenerative neural signaling. PMID:10818554

Cariani, P

2000-01-01

125

RENEWABLE REGENERATIVE ENERGY SYSTEMS: PRACTICAL INTEGRATION CHALLENGES  

Microsoft Academic Search

Interest in renewable energy systems that employ regenerative components to enable intermittent energy sources to service time varying loads is growing. The overall performance of these systems is intimately linked to the choice of the energy storage media and the efficiency of the energy conversion devices. Recent advances in electrolyser and fuel cell technologies may make small-scale hydrogen buffered renewable

Alvin Bergen; Ned Djilali; Lawrence Pitt; Andrew Rowe

126

Regenerative medicine of the pancreatic ? cells  

Microsoft Academic Search

Diabetes mellitus is a metabolic disorder that affects millions of people. The number of patients suffering from diabetes continues to increase all over the world. Both type 1 and type 2 diabetes result from an inadequate mass of functioning ß cells. To achieve the ultimate goal of curing diabetes in the future, the mechanism of the regenerative process of the

Satoko Yamada; Itaru Kojima

2005-01-01

127

Regenerative fuel cells for space applications  

NASA Technical Reports Server (NTRS)

After several years of development of the regenerative fuel cell (RFC) as the electrochemical storage system to be carried by the future space station, the official stance has now been adopted that nickel hydrogen batteries would be a better system choice. RFCs are compared with nickel hydrogen and other battery systems for space platform applications.

Appleby, A. John

1987-01-01

128

Angiolymphoid Hyperplasia with Eosinophilia with Follicular Mucinosis  

PubMed Central

Follicular mucinosis occurring along with angiolymphoid hyperplasia with eosinophils (ALHE) has been described in a 49-year-old male. The patient presented with pruritic hyperpigmented papules and nodules on the vertex and right parietal scalp. There was no any other complaint. Histopathological examination from one of the papule showed prominent blood vessels in the dermis lined by plump histiocytoid endothelial cells that were surrounded by a dense lymphoid infiltrate with numerous eosinophils; these findings are typical of angiolymphoid hyperplasia with eosinophilia. Features of follicular mucinosis were observed in the same section with 3 hyperplastic follicular infundibula containing pools of mucin in the infundibular epithelium. The concurrent occurrence of these 2 distinct histopathological patterns in the same biopsy specimen has been reported rarely. PMID:23716828

Gutte, Rameshwar; Doshi, Bhavana; Khopkar, Uday

2013-01-01

129

Angiolymphoid hyperplasia with eosinophilia with follicular mucinosis.  

PubMed

Follicular mucinosis occurring along with angiolymphoid hyperplasia with eosinophils (ALHE) has been described in a 49-year-old male. The patient presented with pruritic hyperpigmented papules and nodules on the vertex and right parietal scalp. There was no any other complaint. Histopathological examination from one of the papule showed prominent blood vessels in the dermis lined by plump histiocytoid endothelial cells that were surrounded by a dense lymphoid infiltrate with numerous eosinophils; these findings are typical of angiolymphoid hyperplasia with eosinophilia. Features of follicular mucinosis were observed in the same section with 3 hyperplastic follicular infundibula containing pools of mucin in the infundibular epithelium. The concurrent occurrence of these 2 distinct histopathological patterns in the same biopsy specimen has been reported rarely. PMID:23716828

Gutte, Rameshwar; Doshi, Bhavana; Khopkar, Uday

2013-03-01

130

Pancreatic polypeptide cell hyperplasia of the pancreas.  

PubMed

A case of pancreatic polypeptide cell hyperplasia in a 76-year-old man who presented with subacute bowel pseudo-obstruction is reported. A computed tomography scan incidentally showed a pancreatic head lesion that was resected by pancreaticoduodenectomy. Histological examination showed expansion of the endocrine pancreas with increased numbers of pancreatic polypeptide cells in irregularly enlarged islets, ragged endocrine cell clusters, ductulo-insular complexes and microadenomas. The clinicopathological features of this rare and poorly understood condition are discussed. PMID:17021132

Albazaz, R; Da Costa, P E; Verbeke, C S

2006-10-01

131

Saw Palmetto for Benign Prostatic Hyperplasia  

Microsoft Academic Search

In this double-blind trial, we randomly assigned 225 men over the age of 49 years who had moderate-to-severe symptoms of benign prostatic hyperplasia to one year of treatment with saw palmetto extract (160 mg twice a day) or placebo. The pri- mary outcome measures were changes in the scores on the American Urological Association Symptom Index (AUASI) and the maximal

Stephen Bent; Christopher Kane; Katsuto Shinohara; John Neuhaus; Esther S. Hudes; Harley Goldberg; Andrew L. Avins

2006-01-01

132

Intra-arterial angiolymphoid hyperplasia with eosinophilia.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare skin disorder of unknown etiology. This paper describes the case of a 34-year-old man with a lesion located on the right part of his forehead. Microscopically, it displayed a typical morphology of ALHE. However, it was exceptional by its intra-arterial location and its prominent lymphocytic rim-like component. Differential diagnoses, with special emphasis to organized thrombosis and juvenile arteritis, are discussed here. PMID:17976207

Koubaa, Wafa; Verdier, Michel; Perez, Michael; Wechsler, Janine

2008-05-01

133

[Focal epithelial hyperplasia in lepromatous leprosy].  

PubMed

Focal epithelial hyperplasia Heck (FEH) is most likely caused by human papilloma virus. It mainly occurs in children and young people showing no associated diseases. For the first time, we describe a case of FEH in a patient with lepromatous leprosy who due to persistent erythema nodosum leprosum has been treated with a lang-term glucocorticoid therapy. The question of the competence of lepromatous patients in resisting certain viral infections arises. PMID:6649746

Jacyk, W; Lechner, W

1983-10-15

134

Unilateral condylar hyperplasia: A case report and review of literature  

PubMed Central

Condylar hyperplasia is (CH) an uncommon malformation of the mandible involving change in size and morphology of the condylar neck and head. CH is an anomaly that usually occurs unilaterally and equally affects in both men and women. Hyperplasia of the condyle ‘differentiated into hemimandibular hyperplasia, hemimandibular elongation and CH. Here, we are presenting a case of 17-year-old male patient with unilateral CH and its review of the literature. PMID:24818099

Bharathi, Saravana C.; Senthilnathan, S.; Kumar, Lokesh D.; Mohan, Anand C. S.; Taranath, M.

2014-01-01

135

Unitized Regenerative Fuel Cell System Model Development  

NASA Technical Reports Server (NTRS)

A Unitized Regenerative Fuel Cell (URFC) Energy Storage System is being developed at the NASA Glenn Research Center. This URFC system is unique in that it uses the surface area of the hydrogen and oxygen storage tanks as radiating heat surfaces for overall thermal control of the system. The tank surfaces also play an important role in the temperature control of regenerative gas dryers/humidifiers used to dry the hydrogen and oxygen gases produced by electrolysis during the charging and also used to humidify the hydrogen and oxygen gases used by fuel cell during the discharging of the URFCS. A bi- directional pressure controller is used to control the pressure of the oxygen and hydrogen gas inside the URFC stack during both charging and discharging of the URFC system. A water storage accumulator is used to store water reactant and control water pressure inside the URFC stack.

Burke, Kenneth A.; Jakupca, Ian

2003-01-01

136

Regenerative Cell Therapy for Corneal Endothelium.  

PubMed

Endothelial cell dysfunction as in Fuchs dystrophy or pseudophakic bullous keratopathy, and the limited regenerative capacity of human corneal endothelial cells (HCECs), drive the need for corneal transplant. In response to limited donor corneal availability, significant effort has been directed towards cell therapy as an alternative to surgery. Stimulation of endogenous progenitors, or transplant of stem cell-derived HCECs or in vitro-expanded, donor-derived HCECs could replace traditional surgery with regenerative therapy. Ex vivo expansion of HCECs is technically challenging, and the basis for molecular identification of functional HCECs is not established. Delivery of cells to the inner layer of the human cornea is another challenge: different techniques, from simple injection to artificial corneal scaffolds, are being investigated. Despite remaining questions, corneal endothelial cell therapies, translated to the clinic, represent the future for the treatment of corneal endotheliopathies. PMID:25328857

Bartakova, Alena; Kunzevitzky, Noelia J; Goldberg, Jeffrey L

2014-09-01

137

Endometrial stem cells in regenerative medicine  

PubMed Central

First described in 2004, endometrial stem cells (EnSCs) are adult stem cells isolated from the endometrial tissue. EnSCs comprise of a population of epithelial stem cells, mesenchymal stem cells, and side population stem cells. When secreted in the menstrual blood, they are termed menstrual stem cells or endometrial regenerative cells. Mounting evidence suggests that EnSCs can be utilized in regenerative medicine. EnSCs can be used as immuno-modulatory agents to attenuate inflammation, are implicated in angiogenesis and vascularization during tissue regeneration, and can also be reprogrammed into induced pluripotent stem cells. Furthermore, EnSCs can be used in tissue engineering applications and there are several clinical trials currently in place to ascertain the therapeutic potential of EnSCs. This review highlights the progress made in EnSC research, describing their mesodermal, ectodermal, and endodermal potentials both in vitro and in vivo. PMID:25097665

2014-01-01

138

Regenerative Endodontics: A Road Less Travelled  

PubMed Central

Although traditional approaches like root canal therapy and apexification procedures have been successful in treating diseased or infected root canals, but these modalities fail to re-establish healthy pulp tissue in treated teeth. Regeneration-based approaches aims to offer high levels of success by replacing diseased or necrotic pulp tissues with healthy pulp tissue to revitalize teeth. The applications of regenerative approaches in dental clinics have potential to dramatically improve patients’ quality of life. This review article offers a detailed overview of present regenerative endodontic approaches aiming to revitalize teeth and also outlines the problems to be dealt before this emerging field contributes to clinical treatment protocols. It conjointly covers the basic trilogy elements of tissue engineering. PMID:25478476

Bansal, Ramta; Mittal, Sunandan; Kumar, Tarun; Kaur, Dilpreet

2014-01-01

139

Electrospun Silk Biomaterial Scaffolds for Regenerative Medicine  

PubMed Central

Electrospinning is a versatile technique that enables the development of nanofiber-based biomaterial scaffolds. Scaffolds can be generated that are useful for tissue engineering and regenerative medicine since they mimic the nanoscale properties of certain fibrous components of the native extracellular matrix in tissues. Silk is a natural protein with excellent biocompatibility, remarkable mechanical properties as well as tailorable degradability. Integrating these protein polymer advantages with electrospinning results in scaffolds with combined biochemical, topographical and mechanical cues with versatility for a range of biomaterial, cell and tissue studies and applications. This review covers research related to electrospinning of silk, including process parameters, post treatment of the spun fibers, functionalization of nanofibers, and the potential applications for these material systems in regenerative medicine. Research challenges and future trends are also discussed. PMID:19643154

Zhang, Xiaohui; Reagan, Michaela R; Kaplan, David L.

2009-01-01

140

Regenerative nanomedicines: an emerging investment prospective?  

PubMed

Cells respond to their structural surrounding and within nanostructures exhibit unique proliferative and differentiation properties. The application of nanotechnologies to the field of regenerative medicine offers the potential to direct cell fate, target the delivery of cells and reduce immune rejection (via encapsulation), thereby supporting the development of regenerative medicines. The overall objective of any therapy is the delivery of the product not just into the clinic but also to patients on a routine basis. Such a goal typically requires a commercial vehicle and substantial levels of investment in scientific, clinical, regulatory and business expertise, resources, time and funding. Therefore, this paper focuses on some of the challenges facing this emerging industry, including investment by the venture capital community. PMID:20826478

Prescott, Catherine

2010-12-01

141

Regenerative hybrid arrays for interference suppression  

NASA Astrophysics Data System (ADS)

The authors propose two regenerative hybrid adaptive arrays in which a self-generated reference signal is obtained through a detection-modulation procedure from the array output. The proposed arrays do not depend on spectrum spreading and are therefore applicable when this feature is not available. It is shown that at steady state the performance of these regenerative hybrid arrays is approximately the same as that of a hybrid array with a perfect reference signal. As to transient behavior, these arrays are shown to converge if the available imperfect steering vector can result in a few dB output signal-to-interference-plus-noise ratio with the self-generated reference disabled.

Yeh, Chien-Chung; Chao, Tzy-Hong; Haber, Fred

1989-05-01

142

Micro-Scale Regenerative Heat Exchanger  

NASA Technical Reports Server (NTRS)

A micro-scale regenerative heat exchanger has been designed, optimized and fabricated for use in a micro-Stirling device. Novel design and fabrication techniques enabled the minimization of axial heat conduction losses and pressure drop, while maximizing thermal regenerative performance. The fabricated prototype is comprised of ten separate assembled layers of alternating metal-dielectric composite. Each layer is offset to minimize conduction losses and maximize heat transfer by boundary layer disruption. A grating pattern of 100 micron square non-contiguous flow passages were formed with a nominal 20 micron wall thickness, and an overall assembled ten-layer thickness of 900 microns. Application of the micro heat exchanger is envisioned in the areas of micro-refrigerators/coolers, micropower devices, and micro-fluidic devices.

Moran, Matthew E.; Stelter, Stephan; Stelter, Manfred

2004-01-01

143

On the Dynamics of Regenerative Frequency Dividers  

Microsoft Academic Search

A comprehensive analytical study of regenerative frequency dividers (RFD) is presented. The study includes two fundamental modes of operation in RFDs, namely locked (or stable) and quasi-locked modes, and the study also covers the transition from free-running oscillation to quasi-locked, and ultimately to locked operation mode. Differential equations characterizing the RFD behavior for both operation modes as well as the

Aminghasem Safarian; Seema Anand; Payam Heydari

2006-01-01

144

Low temperature thermally regenerative electrochemical system  

DOEpatents

A thermally regenerative electrochemical system including an electrochemical cell with two water-based electrolytes separated by an ion exchange membrane, at least one of the electrolytes containing a complexing agent and a salt of a multivalent metal whose respective order of potentials for a pair of its redox couples is reversible by a change in the amount of the complexing agent in the electrolyte, the complexing agent being removable by distillation to cause the reversal.

Loutfy, Raouf O. (Tucson, AZ); Brown, Alan P. (Bolingbrook, IL); Yao, Neng-Ping (Clarendon Hills, IL)

1983-01-01

145

Low-temperature thermally regenerative electrochemical system  

DOEpatents

A thermally regenerative electrochemical system is described including an electrochemical cell with two water-based electrolytes separated by an ion exchange membrane, at least one of the electrolytes containing a complexing agent and a salt of a multivalent metal whose respective order of potentials for a pair of its redox couples is reversible by a change in the amount of the ocmplexing agent in the electrolyte, the complexing agent being removable by distillation to cause the reversal.

Loutfy, R.O.; Brown, A.P.; Yao, N.P.

1982-04-21

146

Multipotent Progenitor Cells in Regenerative Cardiovascular Medicine  

Microsoft Academic Search

Regenerative therapies for heart diseases require the understanding of the molecular mechanisms that govern the fates and\\u000a differentiation of the diverse muscle and nonmuscle cell lineages that form during heart development. During mouse cardiogenesis,\\u000a the major lineages of the mature heart, cardiomyocytes, smooth muscle, endothelial cells, and cardiac mesenchyme, arise from\\u000a multipotent cardiovascular progenitors expressing the transcription factors Mesp1, Isl1,

Jason T. Lam; Alessandra Moretti; Karl-Ludwig Laugwitz

2009-01-01

147

Optimization of an irreversible Stirling regenerative cycle  

NASA Astrophysics Data System (ADS)

In this work a Stirling regenerative cycle with some irreversibilities is analyzed. The analyzed irreversibilities are located at the heat exchangers. They receive a finite amount of heat and heat leakage occurs between both reservoirs. Using this model, power and the efficiency at maximum power are obtained. Some optimal design parameters for the exchanger heat areas and thermal conductances are presented. The relation between the power, efficiency and the results obtained are shown graphically.

Aragón-González, G.; Cano-Bianco, M.; León-Galicia, A.; Rivera-Camacho, J. M.

2015-01-01

148

A solar regenerative thermoelectrochemical converter (RTEC)  

SciTech Connect

This is an executive summary of a final subcontract report that describes the successful completion of a closed-loop demonstration of a regenerative thermoelectromechanical device using solar heat input for the production of electricity. The full report, which contains a detailed description of the two-year effort, is currently subject to a government secrecy order which precludes public release of the information. Copies of the full report will be made available for general release whenever the secrecy order is lifted.

Townsend, C.W.; McHardy, J. (Hughes Aircraft Co., El Segundo, CA (United States))

1992-02-01

149

Secular Humanist Bioethics and Regenerative Medicine  

Microsoft Academic Search

\\u000a As Daniel Callahan perceptively observed some 20 years ago, issues and dilemmas in bioethics might be new as a result of remarkable\\u000a advances in biomedical science, but the moral questions they raise are “among the oldest that human beings have asked themselves”\\u000a (Callahan, 2004, p. 278). Regenerative Medicine is a cutting edge medicine, devoted to the repair of damaged, diseased,

Ping-Cheung Lo

150

Design Peptide Scaffolds for Regenerative Medicine  

Microsoft Academic Search

\\u000a Regenerative and reparative medicine require two key complementary ingredients: the biological scaffolds and stem cells, both\\u000a embryonic and adult stem cells. Designs of new scaffolds at the molecular level have become increasingly important for such\\u000a an endeavor. New technology through molecular self-assembly as a fabrication tool will become integral part of new medicine\\u000a in the coming years. We are inspired

Shuguang Zhang; Carlos E. Semino

151

Regenerative Hydrogen-Oxygen Fuel Cell  

Microsoft Academic Search

The regenerative hydrogen-oxygen ion-exchange membrane fuel cell is especially suitable for use in space power systems. During discharge, the anode reaction is H2+20H-¿2H2O+2e. The electrons pass out of the fuel cell at the anode to the load, then re-enter at the cathode. The cathode reaction is ½02+H2O+2e ¿20H-. The hydroxyl ions pass through the membrane to the anode; the electrical

S. E. Voltz; M. D. Read

1962-01-01

152

Researches on regenerative medicine-current state and prospect.  

PubMed

Since 1980s, the rapid development of tissue engineering and stem cell research has pushed regenerative medicine to a new fastigium, and regenerative medicine has become a noticeable research field in the international biology and medicine. In China, about 100 million patients need repair and regeneration treatment every year, while the number is much larger in the world. Regenerative medicine could provide effective salvation for these patients. Both Chinese Academy of Sciences and Chinese Academy of Engineering have made roadmaps of 2010-2050 and 2011-2030 for regenerative medicine. The final goal of the two roadmaps is to make China go up to leading position in most research aspects of regenerative medicine. In accord with this strategy, the government and some enterprises have invested 3-5 billion RMB (0.5-0.8 billion USD) for the research on regenerative medicine. In order to push the translation of regenerative medicine forward-from bench to bedside, a strategic alliance has been established, and it includes 27 top-level research institutes, medical institutes, colleges, universities and enterprises in the field of stem cell and regeneration medicine. Recently the journal, Science, has published a special issue-Regenerative Medicine in China, consisting of 35 papers dealing with stem cell and regeneration, tissue engineering and regeneration, trauma and regeneration and bases for tissue repair and regenerative medicine. It is predicated that a greater breakthrough in theory and practice of regenerative medicine will be achieved in the near future (20 to 30 years). PMID:23069095

Wang, Zheng-Guo; Xiao, Kai

2012-01-01

153

Regenerative scaffold electrodes for peripheral nerve interfacing.  

PubMed

Advances in neural interfacing technology are required to enable natural, thought-driven control of a prosthetic limb. Here, we describe a regenerative electrode design in which a polymer-based thin-film electrode array is integrated within a thin-film sheet of aligned nanofibers, such that axons regenerating from a transected peripheral nerve are topographically guided across the electrode recording sites. Cultures of dorsal root ganglia were used to explore design parameters leading to cellular migration and neurite extension across the nanofiber/electrode array boundary. Regenerative scaffold electrodes (RSEs) were subsequently fabricated and implanted across rat tibial nerve gaps to evaluate device recording capabilities and influence on nerve regeneration. In 20 of these animals, regeneration was compared between a conventional nerve gap model and an amputation model. Characteristic shaping of regenerated nerve morphology around the embedded electrode array was observed in both groups, and regenerated axon profile counts were similar at the eight week end point. Implanted RSEs recorded evoked neural activity in all of these cases, and also in separate implantations lasting up to five months. These results demonstrate that nanofiber-based topographic cues within a regenerative electrode can influence nerve regeneration, to the potential benefit of a peripheral nerve interface suitable for limb amputees. PMID:23033438

Clements, Isaac P; Mukhatyar, Vivek J; Srinivasan, Akhil; Bentley, John T; Andreasen, Dinal S; Bellamkonda, Ravi V

2013-07-01

154

Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children  

E-print Network

Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder intestinal abnormalities, ranging from lymphoid nodular hyperplasia to aphthoid ulceration. Histology showed

Chapman, Michael S.

155

Feminizing genital reconstruction in congenital adrenal hyperplasia  

PubMed Central

The past several decades have seen multiple advances in the surgical reconstruction for girls born with Disorders of Sexual Differentiation. This surgery can be technically very demanding, and must be individualized for each patient, as the degree of virilization and level of confluence of the vagina and urogenital sinus will dictate the surgical approach. In this manuscript we present our approach and experience in the surgical options for girls born with Congenital Adrenal Hyperplasia, with special attention regarding clitoroplasty, urogenital mobilization, and vaginoplasty. PMID:19468424

Leslie, Jeffrey A.; Cain, Mark Patrick; Rink, Richard Carlos

2009-01-01

156

Inflammation in benign prostatic hyperplasia: A 282 patients' immunohistochemical analysis  

E-print Network

: +33149812568 E-mail address: adelataille@hotmail.com Running Head Title: BPH and inflammation Word Count: Abstract: 220 Manuscript: 2320 Figure: 1 Tables: 4 Key Words: Benign prostatic hyperplasia; BPH inflammation could be a key component in prostate enlargement and benign prostatic hyperplasia (BPH

Paris-Sud XI, Université de

157

Prenatal Diagnosis and Treatment of Congenital Adrenal Hyperplasia  

Microsoft Academic Search

Congenital adrenal hyperplasia is a group of inherited disorders caused by an enzyme deficiency in steroid biosynthesis. The most common form of congenital adrenal hyperplasia is 21-hydroxylase deficiency, which in its severe form can cause genital ambiguity in females. Steroid 21-hydroxylase deficiency can be diagnosed in utero through molecular genetic analysis of fetal DNA. Prenatal treatment successfully reduces genital ambiguity,

Saroj Nimkarn; Maria I. New

2007-01-01

158

Clinical and Imaging Findings of True Hemifacial Hyperplasia  

PubMed Central

Congenital hemifacial hyperplasia is a rare developmental disorder of unknown etiology, characterized by a marked unilateral facial asymmetry. It involves the hard (bones and teeth) and soft tissues of the face. We report an interesting case of true hemifacial hyperplasia in a 25-year-old male highlighting the clinical and computed tomography imaging findings. PMID:24349801

Bhuta, Bansari A.; Desai, Rajiv S.; Bansal, Shivani P.; Chemburkar, Vipul V.; Dev, Prashant V.

2013-01-01

159

Genetics of primary macronodular adrenal hyperplasia.  

PubMed

ACTH-independent macronodular adrenal hyperplasia is a rare cause of Cushing's syndrome (CS), accounting for <2% of all endogenous CS cases; however it is more frequently identified incidentally with sub-clinical cortisol secretion. Recently, cortisol secretion has been shown to be regulated by ectopic corticotropin, which is in turn produced by clusters of steroidogenic cells of the hyperplastic adrenal nodules. Hence, the term 'ACTH-independent' is not entirely appropriate for this disorder. Accordingly, the disease is designated primary macronodular adrenal hyperplasia (PMAH) in this review article. The means by which cortisol production is regulated in PMAH despite the suppressed levels of ACTH of pituitary origin is exceedingly complex. Several molecular events have been proposed to explain the enhanced cortisol secretion, increased cell proliferation, and nodule formation in PMAH. Nonetheless, the precise sequence of events and the molecular mechanisms underlying this condition remain unclear. The purpose of this review is therefore to present new insights on the molecular and genetic profile of PMAH pathophysiology, and to discuss the implications for disease progression. PMID:25472909

Fragoso, Maria Candida Barisson Villares; Alencar, Guilherme Asmar; Lerario, Antonio Marcondes; Bourdeau, Isabelle; Almeida, Madson Queiroz; Mendonca, Berenice Bilharinho; Lacroix, André

2015-01-01

160

The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine  

E-print Network

Biomechanical factors profoundly influence the processes of tissue growth, development, maintenance, degeneration, and repair. Regenerative strategies to restore damaged or diseased tissues in vivo and create living tissue ...

Butler, David L.

161

A Regeneratively-Cooled Thrust Chamber for the Fastrac Engine  

NASA Technical Reports Server (NTRS)

This document consists of presentation slides about the development of the regeneratively cooled thrust chamber for the Fastrac engine. The Fastrac engine was originally developed to demonstrate low cost design and fabrication methods. It was intended to be used in an expendable booster. The regen thrust chamber enables a more cost efficient test program. Using the low cost design and fabrication methodology designed for the 12K regeneratively cooled chamber, the contractor designed, developed and fabricated a regeneratively cooled thrust chamber for the Fastrac engine.

Brown, Kendall; Sparks, Dave; Woodcock, Gordon; Jim Turner (Technical Monitor)

2000-01-01

162

Platelet rich fibrin - a novel acumen into regenerative endodontic therapy  

PubMed Central

Research into regenerative dentistry has added impetus onto the field of molecular biology. It can be documented as a prototype shift in the therapeutic armamentarium for dental disease. Regenerative endodontic procedures are widely being added to the current armamentarium of pulp therapy procedures. The regenerative potential of platelets has been deliberated. A new family of platelet concentrates called the platelet rich fibrin (PRF) has been recently used by several investigators and has shown application in diverse disciplines of dentistry. This paper is intended to add light on the various prospects of PRF and clinical insights to regenerative endodontic therapy. PMID:24516822

Sharma, Krishna

2014-01-01

163

Regenerative Blower for EVA Suit Ventilation Fan  

NASA Technical Reports Server (NTRS)

Portable life support systems in future space suits will include a ventilation subsystem driven by a dedicated fan. This ventilation fan must meet challenging requirements for pressure rise, flow rate, efficiency, size, safety, and reliability. This paper describes research and development that showed the feasibility of a regenerative blower that is uniquely suited to meet these requirements. We proved feasibility through component tests, blower tests, and design analysis. Based on the requirements for the Constellation Space Suit Element (CSSE) Portable Life Support System (PLSS) ventilation fan, we designed the critical elements of the blower. We measured the effects of key design parameters on blower performance using separate effects tests, and used the results of these tests to design a regenerative blower that will meet the ventilation fan requirements. We assembled a proof-of-concept blower and measured its performance at sub-atmospheric pressures that simulate a PLSS ventilation loop environment. Head/flow performance and maximum efficiency point data were used to specify the design and operating conditions for the ventilation fan. We identified materials for the blower that will enhance safety for operation in a lunar environment, and produced a solid model that illustrates the final design. The proof-of-concept blower produced the flow rate and pressure rise needed for the CSSE ventilation subsystem while running at 5400 rpm, consuming only 9 W of electric power using a non-optimized, commercial motor and controller and inefficient bearings. Scaling the test results to a complete design shows that a lightweight, compact, reliable, and low power regenerative blower can meet the performance requirements for future space suit life support systems.

Izenson, Michael G.; Chen, Weibo; Paul, Heather L.

2010-01-01

164

Clinical concepts for regenerative therapy in furcations.  

PubMed

Furcation involvements present one of the greatest challenges in periodontal therapy because furcation-involved molar teeth respond less favorably to conventional periodontal therapy compared with noninvolved molar or nonmolar teeth. Various regenerative procedures have been proposed and applied with the aim of eliminating the furcation defect or reducing the furcation depth. An abundance of studies and several systematic reviews have established the effectiveness of membrane therapy (guided tissue regeneration) for buccal Class II furcation involvement of mandibular and maxillary molars compared with open flap surgery. Bone grafts/substitutes may enhance the results of guided tissue regeneration. However, complete furcation closure is not a predictable outcome. Limited data and no meta-analyses are available on the effects of enamel matrix proteins for furcation regeneration. Enamel matrix protein therapy has demonstrated clinical improvements in the treatment of buccal Class II furcation defects in mandibular molars; however, complete closure of the furcation lesion is achieved only in a minority of cases. Neither guided tissue regeneration nor enamel matrix protein therapy have demonstrated predictable results for approximal Class II and for Class III furcations. Promising preclinical data from furcation regeneration studies in experimental animals is available for growth factor- and differentiation factor-based technologies, but very limited data are available from human clinical studies. Although cell-based therapies have received considerable attention in regenerative medicine, their experimental evaluation in the treatment of periodontal furcation lesions is at a very early stage of development. In summary, the indications and the limitations for currently available treatment modalities for furcation defects are well established. New regenerative treatments are clearly needed to improve the predictability of a complete resolution of furcation defects. PMID:25867991

Sanz, Mariano; Jepsen, Karin; Eickholz, Peter; Jepsen, Søren

2015-06-01

165

Transpiration And Regenerative Cooling Of Rocket Engine  

NASA Technical Reports Server (NTRS)

Transpiration cooling extends limits of performance. Addition of transpiration cooling to regeneratively-cooled rocket-engine combustion chamber proposed. Modification improves performance of engine by allowing use of higher chamber pressure. Throat section of combustion-chamber wall cooled by transpiration, while chamber and nozzle sections cooled by fluid flowing in closed channels. Concept applicable to advanced, high-performance terrestrial engines or some kinds of industrial combustion chambers. With proper design, cooling scheme makes possible to achieve higher chamber pressure and higher overall performance in smaller engine.

Obrien, Charles J.

1989-01-01

166

Regenerative nanotechnology in oral and maxillofacial surgery.  

PubMed

Regenerative nanotechnology is at the forefront of medical research, and translational medicine is a challenge to both scientists and clinicians. Although there has been an exponential rise in the volume of research generated about it for both medical and surgical uses, key questions remain about its actual benefits. Nevertheless, some people think that therapeutics based on its principles may form the core of applied research for the future. Here we give an account of its current use in oral and maxillofacial surgery, and implications and challenges for the future. PMID:25218313

Shakib, Kaveh; Tan, Aaron; Soskic, Vukic; Seifalian, Alexander M

2014-12-01

167

Feasibility investigation of allogeneic endometrial regenerative cells  

PubMed Central

Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like stem cells having pluripotent differentiation activity and ability to induce neoangiogenesis. In vitro and animal studies suggest ERC are immune privileged and in certain situations actively suppress ongoing immune responses. In this paper we describe the production of clinical grade ERC and initial safety experiences in 4 patients with multiple sclerosis treated intravenously and intrathecally. The case with the longest follow up, of more than one year, revealed no immunological reactions or treatment associated adverse effects. These preliminary data suggest feasibility of clinical ERC administration and support further studies with this novel stem cell type. PMID:19232091

Zhong, Zhaohui; Patel, Amit N; Ichim, Thomas E; Riordan, Neil H; Wang, Hao; Min, Wei-Ping; Woods, Erik J; Reid, Michael; Mansilla, Eduardo; Marin, Gustavo H; Drago, Hugo; Murphy, Michael P; Minev, Boris

2009-01-01

168

Feasibility investigation of allogeneic endometrial regenerative cells.  

PubMed

Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like stem cells having pluripotent differentiation activity and ability to induce neoangiogenesis. In vitro and animal studies suggest ERC are immune privileged and in certain situations actively suppress ongoing immune responses. In this paper we describe the production of clinical grade ERC and initial safety experiences in 4 patients with multiple sclerosis treated intravenously and intrathecally. The case with the longest follow up, of more than one year, revealed no immunological reactions or treatment associated adverse effects. These preliminary data suggest feasibility of clinical ERC administration and support further studies with this novel stem cell type. PMID:19232091

Zhong, Zhaohui; Patel, Amit N; Ichim, Thomas E; Riordan, Neil H; Wang, Hao; Min, Wei-Ping; Woods, Erik J; Reid, Michael; Mansilla, Eduardo; Marin, Gustavo H; Drago, Hugo; Murphy, Michael P; Minev, Boris

2009-01-01

169

Phosphorous-Containing Polymers for Regenerative Medicine  

PubMed Central

Disease and injury have resulted in a large, unmet need for functional tissue replacements. Polymeric scaffolds can be used to deliver cells and bioactive signals to address this need for regenerating damaged tissue. Phosphorous-containing polymers have been implemented to improve and accelerate the formation of native tissue both by mimicking the native role of phosphorous groups in the body and by attachment of other bioactive molecules. This manuscript reviews the synthesis, properties, and performance of phosphorous-containing polymers that can be useful in regenerative medicine applications. PMID:24565855

Watson, Brendan M.; Kasper, F. Kurtis; Mikos, Antonios G.

2014-01-01

170

Model Systems for Cardiovascular Regenerative Biology  

PubMed Central

There is an urgent clinical need to develop new therapeutic approaches to treat heart failure, but the biology of cardiovascular regeneration is complex. Model systems are required to advance our understanding of biological mechanisms of cardiac regeneration as well as to test therapeutic approaches to regenerate tissue and restore cardiac function following injury. An ideal model system should be inexpensive, easily manipulated, easily reproducible, physiologically representative of human disease, and ethically sound. In this review, we discuss computational, cell-based, tissue, and animal models that have been used to elucidate mechanisms of cardiovascular regenerative biology or to test proposed therapeutic methods to restore cardiac function following disease or injury. PMID:23545574

Garbern, Jessica C.; Mummery, Christine L.

2013-01-01

171

Small Molecule based Musculoskeletal Regenerative Engineering  

PubMed Central

Clinicians and scientists working in the field of regenerative engineering are actively investigating a wide range of methods to promote musculoskeletal tissue regeneration. Small molecule-mediated tissue regeneration is emerging as a promising strategy for regenerating various musculoskeletal tissues and a large number of small molecule compounds have been recently discovered as potential bioactive molecules for musculoskeletal tissue repair and regeneration. In this review, we summarize the recent literature encompassing the past four years in the area of small bioactive molecule for promoting repair and regeneration of various musculoskeletal tissues including bone, muscle, cartilage, tendon, and nerve. PMID:24405851

Lo, Kevin W.-H.; Jiang, Tao; Gagnon, Keith A.; Nelson, Clarke; Laurencin, Cato T.

2014-01-01

172

Regenerative Electronic Biosensors Using Supramolecular Approaches  

PubMed Central

A supramolecular interface for Si nanowire FETs has been developed with the aim of creating regenerative electronic biosensors. The key to the approach are Si-NWs functionalized with ?-Cyclodextrin (?-CD), to which receptor moieties can be attached with an orthogonal supramolecular linker. Here we demonstrate full recycling using the strongest biomolecular system known, streptavidin (SAv)-biotin. The bound SAv and the linkers can be selectively removed from the surface through competitive desorption with concentrated ?-CD, regenerating the sensor for repeated use. An added advantage of ?-CD is the possibility of stereoselective sensors, and we demonstrate here the ability to quantify the enantiomeric composition of chiral targets. PMID:23566420

Duan, Xuexin; Rajan, Nitin K.; Routenberg, David A.; Huskens, Jurriaan

2013-01-01

173

78 FR 43889 - Synergizing Efforts in Standards Development for Cellular Therapies and Regenerative Medicine...  

Federal Register 2010, 2011, 2012, 2013, 2014

...for Cellular Therapies and Regenerative Medicine Products; Public Workshop AGENCY: Food...for Cellular Therapies and Regenerative Medicine Products.'' The purpose of the public...involving cellular therapies and regenerative medicine products. Date and Time: The...

2013-07-22

174

Langerhans Cell Hyperplasia From Molluscum Contagiosum.  

PubMed

: Langerhans cell histiocytosis (LCH) carries a prognosis, which ranges from benign to potentially fatal. There is currently little framework to decipher metrics, which predict the benign versus aggressive nature of LCH. We wanted to determine whether molluscum contagiosum virus (MCV) DNA could be isolated from a cutaneous lesion, demonstrating Langerhans cell hyperplasia resembling LCH in a patient with both. Polymerase chain reaction on biopsy-proven MCV and the hyperplastic lesion has been performed. Two specific regions within the MCV genome were detected from both biopsies. The authors report our findings and suggest that some MCV can produce histological lesions resembling LCH, similar to the literature on scabies mimicking LCH. Efforts to find a reactive "driver" in LCH may significantly inform the clinical scenario. PMID:25140667

Hatter, Alyn D; Zhou, Xin; Honda, Kord; Popkin, Daniel L

2014-08-19

175

Congenital adrenal hyperplasia: Treatment and outcomes  

PubMed Central

Congenital adrenal hyperplasia (CAH) describes a group of autosomal recessive disorders where there is impairment of cortisol biosynthesis. CAH due to 21-hydroxylase deficiency accounts for 95% of cases and shows a wide range of clinical severity. Glucocorticoid and mineralocorticoid replacement therapies are the mainstays of treatment of CAH. The optimal treatment for adults with CAH continues to be a challenge. Important long-term health issues for adults with CAH affect both men and women. These issues may either be due to the disease or to steroid treatment and may affect final height, fertility, cardiometabolic risk, bone metabolism, neuro-cognitive development and the quality-of-life. Patients with CAH should be regularly followed-up from childhood to adulthood by multidisciplinary teams who have knowledge of CAH. Optimal replacement therapy, close clinical and laboratory monitoring, early life-style interventions, early and regular fertility assessment and continuous psychological management are needed to improve outcome. PMID:24251136

Kamoun, Mahdi; Feki, Mouna Mnif; Sfar, Mohamed Habib; Abid, Mohamed

2013-01-01

176

Rete testis adenomatous hyperplasia: our experience.  

PubMed

The word "adenomatous hyperplasia of rete testis" (AHRT) was used by M. Nistal et Al. for the first time in an article about the cystic dysplasia of the testis (1976). AHRT is a benign lesion of the testis. The patient who came to our attention was studied with a testicular echo color Doppler that identified a solid, well circumscribed and hypoechoic mass of 4.5 x3.8mm as diameter, localized in the upper third of the right testicle and with a perilesional vascularization pattern. The preoperative study was based on an accurate medical history, on an ultrasound with contrast and on a RMI. The treatment consisted in an echo guided excisional biopsy of the testicular lesion, considering this as the best approach for those testicular neoformation difficult to define, with a lot of benefits for the patients, especially for those monorchid. PMID:24311150

Martino, Giovanni; Pasta, Vittorio; Ciardi, Antonio; Palmieri, Andrea; Marinaccio, Lucia; Malavenda, Maria Stella; Monti, Massimo

2013-01-01

177

Angiolymphoid hyperplasia with eosinophilia on the palm.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon dermal angioproliferating tumor, characterized by red to brown papules or nodules on the head and neck, though also occurring in the mouth, trunk, extremities and inguinal area. The palm is a very unusual site for ALHE, and there have been very few cases reported globally thus far. ALHE can be pruritic and painful and histopathologic findings show vascular proliferation with infiltration of eosinophils and lymphocytes in the dermis. Plump endothelial cells protrude into the lumen. We report a case of ALHE occurring at an unusual site, the right palm, in a 62-year-old man, who had suffered from a solitary pinkish-colored, central depressed round hyperkeratotic plaque on his palm for 4 years. On the basis of clinical and histopathologic data, a diagnosis of ALHE was made. To our knowledge, this is the first report of ALHE on the palm in Korean dermatologic literature. PMID:20711280

Kim, Seong Min; Yoon, Jimi; Yoon, Tae-Jin

2010-08-01

178

Angiolymphoid Hyperplasia with Eosinophilia on the Palm  

PubMed Central

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon dermal angioproliferating tumor, characterized by red to brown papules or nodules on the head and neck, though also occurring in the mouth, trunk, extremities and inguinal area. The palm is a very unusual site for ALHE, and there have been very few cases reported globally thus far. ALHE can be pruritic and painful and histopathologic findings show vascular proliferation with infiltration of eosinophils and lymphocytes in the dermis. Plump endothelial cells protrude into the lumen. We report a case of ALHE occurring at an unusual site, the right palm, in a 62-year-old man, who had suffered from a solitary pinkish-colored, central depressed round hyperkeratotic plaque on his palm for 4 years. On the basis of clinical and histopathologic data, a diagnosis of ALHE was made. To our knowledge, this is the first report of ALHE on the palm in Korean dermatologic literature. PMID:20711280

Kim, Seong Min; Yoon, Jimi

2010-01-01

179

Angiolymphoid hyperplasia with eosinophilia: efficacy of isotretinoin?  

PubMed Central

Background Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign but potentially disfiguring vascular lesion. It is usually characterized by dermal and subcutaneous nodules, primarily in the head and neck region. Spontaneous regression is common, but persistent or recurrent lesions may require treatment. Several treatments have been reported but surgery is the most efficient one. Methods and results We report a 32-year-old man presenting with multiple nodules on the cheeks, preauricular region and the scalp and who received treatment with isotretinoin (0.5 mg/kg/day) for 1 year with complete resolution of one of his scalp nodules. The rest of the lesions remained stable and were treated with surgical excision without recurrence. Conclusion Isotretinoin may play a role in the treatment of ALHE due to its antiangiogenic properties via a reduction of vascular endothelial growth factor (VEGF) production by keratinocytes. PMID:17020619

El Sayed, Fouad; Dhaybi, Rola; Ammoury, Alfred; Chababi, Myrna

2006-01-01

180

Phytotherapy of benign prostatic hyperplasia. A minireview.  

PubMed

Benign prostate hyperplasia (BPH) is a common condition affecting older men, with an incidence that is age-dependent. Histological BPH, which typically develops after the age of 40 years, ranges in prevalence from >50% at 60 years to as high as 90% by 85 years of age. Typical symptoms include increased frequency of urination, nocturia, urgency, hesitancy, and weak urine stream. Conventional medicines used for the treatment of BPH include alpha blockers and 5-alpha reductase inhibitors. This articles review the mode of action, the efficacy, and the safety, including herb-drug interactions of the most common botanicals (Serenoa repens, Pygeum africanum, Urtica dioica, and Cucurbita pepo) and nutraceuticals (isoflavones, lycopene, selenium, and ?-Sitosterol) in controlling the lower urinary tract symptoms associated to BPH. PMID:25165780

Pagano, Ester; Laudato, Massimiliano; Griffo, Michele; Capasso, Raffaele

2014-07-01

181

Optimizing the management of benign prostatic hyperplasia  

PubMed Central

One of the challenges facing primary care physicians and specialists as the population ages is the management of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). While as many as 18% of men in their 40s report bother from an enlarged prostate, that figure rises dramatically, whereby 50% of men in their 50s and 90% of men in their 90s will complain of bothersome symptoms related to an enlarged prostate. Studies have shown that BPH is a progressive disease, which if left untreated can result in worsening of symptoms, acute urinary retention and renal failure. Until about 20 years ago the only management option available to urologists was surgery. In the early 1990s medical therapy emerged as the predominant treatment for BPH. Therapy may be tailored to target symptoms and progression of disease. PMID:22496710

Elterman, Dean S.; Kaplan, Steven A.

2012-01-01

182

Microwave Treatment of Prostate Cancer and Hyperplasia  

NASA Technical Reports Server (NTRS)

Microwave ablation in the form of microwave energy applied to a heart muscle by a coaxial catheter inserted in a vein in the groin area can be used to heat and kill diseased heart cells. A microwave catheter has been developed to provide deep myocardial ablation to treat ventricular tachycardia by restoring appropriate electrical activity within the heart and eliminating irregular heartbeats. The resulting microwave catheter design, which is now being developed for commercial use in treating ventricular tachycardia, can be modified to treat prostate cancer and benign prostatic hyperplasia (BPH). Inasmuch as the occurrence of BPH is increasing currently 350,000 operations per year are performed in the United States alone to treat this condition this microwave catheter has significant commercial potential.

Arndt, G. Dickey; Ngo, Phong; Carl, J. R.; Raffoul, George

2005-01-01

183

Design of Side Channel Type Regenerative Blower  

NASA Astrophysics Data System (ADS)

A side channel type regenerative blower was designed by a one-dimensional performance prediction method and CFD. The design variables, such as the rotating speed, channel height, ratio of cross sectional areas between impeller groove and channel, channel expansion angle and number of blade were set by DOE. To examine the effects of these design variables, the overall performances of 17 different blower designs were estimated by using one-dimensional performance prediction method and analyzed by DOE. The pressure rise and efficiency at the operating flow rate and the flow rate difference between operating and best efficiency condition were selected as the main responses. The main effects of the design variables on the responses were discussed. The rotating speed, channel height and ratio of cross sectional areas between impeller groove and channel affected the overall performance of the blower. Finally, we decided the optimum blower through the results of optimization procedure. To verify the one-dimensional performance prediction method, we calculated the performances of base and optimum design blowers by commercial CFD software (ANSYS CFX-11). The numerical results clearly showed a typical circulation flow characteristics of a side channel type regenerative blower. The tendency of the performance improvement by using CFD was the same with that of the one-dimensional performance prediction method.

Lee, Kyoung-Yong; Choi, Young-Seok; Jeong, Kyung-Ho

2010-06-01

184

Multiple excitation regenerative amplifier inertial confinement system  

DOEpatents

The invention relates to apparatus and methods for producing high intensity laser radiation generation which is achieved through an optical amplifier-storage ring design. One or two synchronized, counterpropagating laser pulses are injected into a regenerative amplifier cavity and amplified by gain media which are pumped repetitively by electrical or optical means. The gain media excitation pulses are tailored to efficiently amplify the laser pulses during each transit. After the laser pulses have been amplified to the desired intensity level, they are either switched out of the cavity by some switch means, as for example an electro-optical device, for any well known laser end uses, or a target means may be injected into the regenerative amplifier cavity in such a way as to intercept simultaneously the counterpropagating laser pulses. One such well known end uses to which this invention is intended is for production of high density and temperature plasmas suitable for generating neutrons, ions and x-rays and for studying matter heated by high intensity laser radiation. 11 figs.

George, V.E.; Haas, R.A.; Krupke, W.F.; Schlitt, L.G.

1980-05-27

185

Multiple excitation regenerative amplifier inertial confinement system  

DOEpatents

The invention relates to apparatus and methods for producing high intensity laser radiation generation which is achieved through an optical amplifier-storage ring design. One or two synchronized, counterpropagating laser pulses are injected into a regenerative amplifier cavity and amplified by gain media which are pumped repetitively by electrical or optical means. The gain media excitation pulses are tailored to efficiently amplify the laser pulses during each transit. After the laser pulses have been amplified to the desired intensity level, they are either switched out of the cavity by some switch means, as for example an electro-optical device, for any well known laser end uses, or a target means may be injected into the regenerative amplifier cavity in such a way as to intercept simultaneously the counterpropagating laser pulses. One such well known end uses to which this invention is intended is for production of high density and temperature plasmas suitable for generating neutrons, ions and x-rays and for studying matter heated by high intensity laser radiation.

George, Victor E. [Livermore, CA; Haas, Roger A. [Pleasanton, CA; Krupke, William F. [Pleasanton, CA; Schlitt, Leland G. [Livermore, CA

1980-05-27

186

Analysis of Regen Cooling in Rocket Combustors  

NASA Technical Reports Server (NTRS)

The use of detailed CFD modeling for the description of cooling in rocket chambers is discussed. The overall analysis includes a complete three-dimensional analysis of the flow in the regenerative cooling passages, conjugate heat transfer in the combustor walls, and the effects of film cooling on the inside chamber. The results in the present paper omit the effects of film cooling and include only regen cooling and the companion conjugate heat transfer. The hot combustion gases are replaced by a constant temperature wall boundary condition. Load balancing for parallel cluster computations is ensured by using single-block unstructured grids for both fluids and solids, and by using a 'multiple physical zones' to account for differences in the number of equations. Validation of the method is achieved by comparing simple two-dimensional solutions with analytical results. Representative results for cooling passages are presents showing the effects of heat conduction in the copper walls with tube aspect ratios of 1.5:l.

Harper, Brent (Technical Monitor); Merkle, C. L.; Li, D.; Sankaran, V.

2004-01-01

187

Integrated regenerative fuel cell experimental evaluation  

NASA Technical Reports Server (NTRS)

An experimental test program was conducted to investigate the performance characteristics of an integrated regenerative fuel cell (IRFC) concept. The IRFC consists of a separate fuel cell unit and electrolysis cell unit in the same structure, with internal storage of fuel cell product water and external storage of electrolysis cell produced hydrogen and oxygen. The fuel cell unit incorporates an enhanced Orbiter-type cell capable of improved performance at reduced weight. The electrolysis cell features a NiCo2O4 catalyst oxygen evolution eletrode with a porous Teflon cover to retard electrolyte loss. Six complete IRFC assemblies were assembled and performance tested at an operating temperature of 200 F (93.3 C) and reactant pressures up to 170 psia (117.2 n/cu cm) on IRFC No. 4. Anomalous pressure charge/discharge characteristics were encountered during performance evaluation. A reversible fuel cell incorporating a proprietary bi-functional oxygen electrode operated satisfactory at 200 F (93.3 C) at reactant pressures up to 50 psia (41.4 n/cu cm) as a regenerative fuel cell for one cycle, before developing an electrical short in the fuel cell mode. Electrolysis cell 300-hour endurance tests demonstrated the electrolyte retention capability of the electrode Teflon cover and the performance stability of the bi-functional oxygen electrode at high potential.

Martin, Ronald E.

1990-01-01

188

Erich Regener - a forgotten cosmic ray pioneer  

NASA Astrophysics Data System (ADS)

In the 1930s the German physicist Erich Regener (1881-1955), did important work on the measurement of the rate production of ionisation in the atmosphere and deep under-water. He discovered, along with one of his students, Georg Pfotzer, the altitude at which the production of ionisation in the atmosphere reaches a maximum, often and misleadingly called the Pfotzer maximum. He was one of the first to estimate the energy density of cosmic rays, an estimate used by Baade and Zwicky to postulate that supernovae might be the source of cosmic rays. Yet Regener's name is little known largely because he was forced to take early retirement by the National Socialists in 1937 as his wife had Jewish ancestors. In this paper we review his work on cosmic rays and the subsequent influence that he had on the subject through his son, his son-in-law, his grandson and his students. He was nominated for the Nobel Prize in Physics by Schroedinger in 1938. He died in 1955 at the age of 73.

Carlson, Per; Watson, Alan

2013-04-01

189

Extracellular Vesicles: Potential Roles in Regenerative Medicine  

PubMed Central

Extracellular vesicles (EV) consist of exosomes, which are released upon fusion of the multivesicular body with the cell membrane, and microvesicles, which are released directly from the cell membrane. EV can mediate cell–cell communication and are involved in many processes, including immune signaling, angiogenesis, stress response, senescence, proliferation, and cell differentiation. The vast amount of processes that EV are involved in and the versatility of manner in which they can influence the behavior of recipient cells make EV an interesting source for both therapeutic and diagnostic applications. Successes in the fields of tumor biology and immunology sparked the exploration of the potential of EV in the field of regenerative medicine. Indeed, EV are involved in restoring tissue and organ damage, and may partially explain the paracrine effects observed in stem cell-based therapeutic approaches. The function and content of EV may also harbor information that can be used in tissue engineering, in which paracrine signaling is employed to modulate cell recruitment, differentiation, and proliferation. In this review, we discuss the function and role of EV in regenerative medicine and elaborate on potential applications in tissue engineering. PMID:25520717

De Jong, Olivier G.; Van Balkom, Bas W. M.; Schiffelers, Raymond M.; Bouten, Carlijn V. C.; Verhaar, Marianne C.

2014-01-01

190

[Biomedical research frontier for regenerative medicine].  

PubMed

Making much of self-renew potential of the living body, "Regenerative Medicine" is sure to play an essential role providing an innovation in treating many human disorders. Although there has been remarkable advances in this field, they are successful only in certain tissues such like vessels or bone/cartilage. When think about the solid organs, i.e. liver or pancreas, it still remains as a huge research frontier. By combining the usage of flow-cytometry and fluorescence-labeled monoclonal antibodies, we had established an elegant methodology of single cell isolation which opened up the way to challenge this "frontier" and it finally led us to the success in identifying/characterizing the stem cells in such organs. Now our research enterprise covers through further understanding of the core stem cell biology to the development of basic technology to realize "Regenerative Medicine" so that we will be able to get reach the achievement to meet the increasing demands of patients suffering these tissues and organs. PMID:15373218

Taniguchi, Hideki

2004-08-01

191

Stem Cells: Intellectual Property Issues in Regenerative Medicine  

PubMed Central

Abstract The topic of stem cells for use in regenerative medicine, especially embryonic stem cells, inspires much debate, discussion, and outrage as it slices through the very core moral values of society. These social and moral issues have, in turn, resulted in government policies that have influenced the study of stem cells in regenerative medicine. PMID:24304078

Zachariades, Nicholas A.

2013-01-01

192

Regenerative thermal storage in atmospheric air system solar power plants  

Microsoft Academic Search

In a regenerative thermal storage system, thermal energy is transferred from a hot working fluid to the storage unit core elements during charging, and from the core elements to the cold working fluid during discharging. Regenerative thermal storage systems are used in many traditional applications, e.g. in steelmaking processes.Supply of solar energy is uncontrollable due to cloud passages. The projected

H. W. Fricker

2004-01-01

193

Physiological Regeneration of Skin Appendages and Implications for Regenerative Medicine  

NSDL National Science Digital Library

The concept of regenerative medicine is relatively new, but animals are well known to remake their hair and feathers regularly by normal regenerative physiological processes. Here, we focus on 1) how extrafollicular environments can regulate hair and feather stem cell activities and 2) how different configurations of stem cells can shape organ forms in different body regions to fulfill changing physiological needs.

Cheng-Ming Chuong (University of Southern California, School of Medicine)

2012-04-01

194

State of the art: stem cells in equine regenerative medicine.  

PubMed

According to Greek mythology, Prometheus' liver grew back nightly after it was removed each day by an eagle as punishment for giving mankind fire. Hence, contrary to popular belief, the concept of tissue and organ regeneration is not new. In the early 20th century, cell culture and ex vivo organ preservation studies by Alexis Carrel, some with famed aviator Charles Lindbergh, established a foundation for much of modern regenerative medicine. While early beliefs and discoveries foreshadowed significant accomplishments in regenerative medicine, advances in knowledge within numerous scientific disciplines, as well as nano- and micromolecular level imaging and detection technologies, have contributed to explosive advances over the last 20 years. Virtually limitless preparations, combinations and applications of the 3 major components of regenerative medicine, namely cells, biomaterials and bioactive molecules, have created a new paradigm of future therapeutic options for most species. It is increasingly clear, however, that despite significant parallels among and within species, there is no 'one-size-fits-all' regenerative therapy. Likewise, a panacea has yet to be discovered that completely reverses the consequences of time, trauma and disease. Nonetheless, there is no question that the promise and potential of regenerative medicine have forever altered medical practices. The horse is a relative newcomer to regenerative medicine applications, yet there is already a large body of work to incorporate novel regenerative therapies into standard care. This review focuses on the current state and potential future of stem cells in equine regenerative medicine. PMID:24957845

Lopez, M J; Jarazo, J

2015-03-01

195

Review on the Unitized Regenerative Fuel Cells Materials  

Microsoft Academic Search

Unitized regenerative fuel cell is a unique fuel cell can work in both electrolyser and fuel cell in one cell at different mode, its useful in some application in which the weight is an important issue. This article reviews current literatures with the objective of identifying the latest development in membrane and bipolar plate materials for the Unitized Regenerative Fuel

SALWAN S. DIHRAB; K. SOPIAN; A. ZAHARIM

196

Evaluation strategy of regenerative braking energy for supercapacitor vehicle.  

PubMed

In order to improve the efficiency of energy conversion and increase the driving range of electric vehicles, the regenerative energy captured during braking process is stored in the energy storage devices and then will be re-used. Due to the high power density of supercapacitors, they are employed to withstand high current in the short time and essentially capture more regenerative energy. The measuring methods for regenerative energy should be investigated to estimate the energy conversion efficiency and performance of electric vehicles. Based on the analysis of the regenerative braking energy system of a supercapacitor vehicle, an evaluation system for energy recovery in the braking process is established using USB portable data-acquisition devices. Experiments under various braking conditions are carried out. The results verify the higher efficiency of energy regeneration system using supercapacitors and the effectiveness of the proposed measurement method. It is also demonstrated that the maximum regenerative energy conversion efficiency can reach to 88%. PMID:25311161

Zou, Zhongyue; Cao, Junyi; Cao, Binggang; Chen, Wen

2015-03-01

197

Angiolymphoid hyperplasia with eosinophilia (alhe) versus kimura's disease : Changing concepts.  

PubMed

The clinico-pathological differences between Kimura's angiolymphoid hyperplasia with eosinophilia are presented to emphasize that they are two separate disease entities which until now were considered as the same disease. PMID:20921651

Maheshwari, V; Sharma, R; Alam, K; Khan, A H

1999-01-01

198

Ortho-surgical management of condylar hyperplasia: Rare case reports  

PubMed Central

Condylar hyperplasia of the mandible is a clinical condition of over-development and growth because of excessive cellular growth of one condylar part of the mandible leading to facial asymmetry, mandibular deviation and enlargement of condyle. The elongation of the condylar neck in turn leads to malocclusion and articular dysfunction. In the past the interceptive and corrective procedures of growth and deformity in condylar hyperplasia were either condylectomy or high condylotomy. However, the deformity ceases after growth is completed. Therefore, other surgical procedures have to be undertaken to correct the manifested deformity of condylar hyperplasia. Further it has to be stressed that no single procedure can completely correct the deformity. So in addition to condylectomy, other orthognathic surgical procedures both on body and ramus and also on maxilla can be undertaken to correct the canting of occlusion. Two rare cases of unilateral hyperplasia encountered in our hospital are presented which required different lines of treatment. PMID:25298720

Singh, Virendra; Verma, Ajay; Attresh, Gyanander; Batra, Jitender

2014-01-01

199

MX-INDUCED URINARY BLADDER EPITHELIAL HYPERPLASIA IN EKER RATS  

EPA Science Inventory

MX-INDUCED URINARY BLADDER EPITHELIAL HYPERPLASIA IN EKER RATS Epidemiological studies have shown a positive association between chronic exposure to chlorinated drinking water and human cancer, particularly of the urinary bladder. MX (3- chloro-4-(dichloromethyl)-5-hydrox...

200

Solar Airplanes and Regenerative Fuel Cells  

NASA Technical Reports Server (NTRS)

A solar electric aircraft with the potential to "fly forever" has captured NASA's interest, and the concept for such an aircraft was pursued under Aeronautics Environmental Research Aircraft and Sensor Technology (ERAST) project. Feasibility of this aircraft happens to depend on the successful development of solar power technologies critical to NASA's Exploration Initiatives; hence, there was widespread interest throughout NASA to bring these technologies to a flight demonstration. The most critical is an energy storage system to sustain mission power during night periods. For the solar airplane, whose flight capability is already limited by the diffuse nature of solar flux and subject to latitude and time of year constraints, the feasibility of long endurance flight depends on a storage density figure of merit better than 400-600 watt-hr per kilogram. This figure of merit is beyond the capability of present day storage technologies (other than nuclear) but may be achievable in the hydrogen-oxygen regenerative fuel cell (RFC). This potential has led NASA to undertake the practical development of a hydrogen-oxygen regenerative fuel cell, initially as solar energy storage for a high altitude UAV science platform but eventually to serve as the primary power source for NASAs lunar base and other planet surface installations. Potentially the highest storage capacity and lowest weight of any non-nuclear device, a flight-weight RFC aboard a solar-electric aircraft that is flown continuously through several successive day-night cycles will provide the most convincing demonstration that this technology's widespread potential has been realized. In 1998 NASA began development of a closed cycle hydrogen oxygen PEM RFC under the Aeronautics Environmental Research Aircraft and Sensor Technology (ERAST) project and continued its development, originally for a solar electric airplane flight, through FY2005 under the Low Emissions Alternative Power (LEAP) project. Construction of the closed loop system began in 2002 at the NASA Glenn Research Center in Cleveland, Ohio. System checkout was completed, and testing began, in July of 2003. The initial test sequences were done with only a fuel cell or electrolyzer in the test rig. Those tests were used to verify the test apparatus, procedures, and software. The first complete cycles of the fully closed loop, regenerative fuel cell system were successfully completed in the following September. Following some hardware upgrades to increase reactant recirculation flow, the test rig was operated at full power in December 2003 and again in January 2004. In March 2004 a newer generation of fuel cell and electrolyzer stacks was substituted for the original hardware and these stacks were successfully tested at full power under cyclic operation in June of 2004.

Bents, David J.

2007-01-01

201

Cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis.  

PubMed

The aim of our study was to investigate cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis in reproductive women with and without polycystic ovarian disease. We have studied 104 patients with a histological diagnosis of ovarian stromal hyperthecosis and stromal hyperplasia. Paraffin sections were stained by hematoxylin-eosin, von Gieson and immunohistochemistry for Bcl-2 (anti-apoptotic protein) and E-cadherin (cell adhesion marker). We assessed the number of Bcl-2-positive and E-cadherin-positive cells. The patients were divided into 4 groups: group 1-33 patients with polycystic ovarian disease and coexistent stromal hyperthecosis, group 2-28 patients with polycystic ovarian disease and coexistent stromal hyperplasia, group 3-24 patients with ovarian stromal hyperthecosis, group 4-19 patients with ovarian stromal hyperplasia. Our results suggest that in ovarian stromal hyperthecosis and stromal hyperplasia coexistent with polycystic ovarian disease, E-cadherin-positivity in internal and external theca cells, and granulosa cells is associated with Bcl-2 expression. Therefore, ovarian cells expressing Bcl-2 and maintaining E-cadherin-positivity may be the viable cells that escape the apoptotic process. In ovarian stromal hyperthecosis without polycystic ovarian disease, luteinized stromal cells are potentially resistant to apoptosis as they are positive for Bcl-2. In ovarian stromal hyperplasia without polycystic ovarian disease, hyperplastic stromal cells are potentially susceptible to apoptosis as they are negative for Bcl-2. E-cadherin is negative both in stromal hyperthecosis and hyperplasia suggesting that E-cadherin expression in ovary is limited to granulosa and theca cells only. Described characteristics of cell adhesion and apoptosis may play a role in pathogenesis of ovarian stromal hyperthecosis and stromal hyperplasia with and without polycystic ovarian disease. PMID:16575127

Sharabidze, N; Burkadze, G; Sabakhtarashvili, M

2006-02-01

202

Why regenerative medicine needs an extracellular matrix.  

PubMed

Regenerative medicine is now coming of age. Many attempts at cell therapy have failed to show significant efficacy, and the umbrella term 'stem cell therapy' is perceived in some quarters as hype or just expensive and unnecessary medical tourism. Here we present a short editorial in three parts. First, we examine the importance of using a semisynthetic extracellular matrix (ECM) mimetic, or sECM, to deliver and retain therapeutic cells at the site of administration. Second, we describe one approach in which biophysical and biochemical properties are tailored to each tissue type, which we call "design for optimal functionality." Third, we describe an alternative approach to sECM design and implementation, called "design for simplicity," in which a deconstructed, minimalist sECM is employed and biology is allowed to perform the customization in situ. We opine that an sECM, whether minimal or instructive, is an essential contributor to improve the outcomes of cell-based therapies. PMID:25482878

Prestwich, Glenn D; Healy, Kevin E

2015-01-01

203

Regenerative system for a gas turbine  

SciTech Connect

A regenerative system is described for a gas turbine, wherein the turbine has a single shaft on which are mounted a compressor section and a work section, comprising: an air heater mounted adjacent the exit of the work section, the hot exit gas and pressurized air passing through passages formed in the air heater; combustor housings surrounding the compressor section, each containing a combustor mounted within it and extending coaxially thereof, each combustor having a transition section extending to the entrance to the work section; an annular connector housing extending between the combustor housing and the exit of the compressor section to carry the compressed air radially; an outer duct leading from the connector housing to one end of the air heater; and an inner duct attached to the other end of the air heater.

Wadsworth, W.

1987-04-28

204

The role of nanophotonics in regenerative medicine.  

PubMed

Cells respond to biochemical and mechanical stimuli through a series of steps that begin at the molecular, nanometre level, and translate finally in global cell response. Defects in biochemical- and/or mechanical-sensing, transduction or cellular response are the cause of multiple diseases, including cancer and immune disorders among others. Within the booming field of regenerative medicine, there is an increasing need for developing and applying nanotechnology tools to bring understanding on the cellular machinery and molecular interactions at the nanoscale. Nanotechnology, nanophotonics and in particular, high-resolution-based fluorescence approaches are already delivering crucial information on the way that cells respond to their environment and how they organize their receptors to perform specialized functions. This chapter focuses on emerging super-resolution optical techniques, summarizing their principles, technical implementation, and reviewing some of the achievements reached so far. PMID:22042685

Garcia-Parajo, Maria F

2012-01-01

205

Regenerative medicine: implications for craniofacial surgery.  

PubMed

Craniofacial reconstruction of cases with complex anatomy challenges surgeons. The recently emerging field of tissue engineering and regenerative medicine has resulted in a variety of novel therapeutic concepts particularly in the craniofacial area. However, researchers still face significant problems when translating scientific concepts from the bench to the bedside. Reconstruction procedures depend on sustainability, aesthetic outcome, and functionality. Tissue engineering approaches yield powerful tools for long-term satisfying results enabling customized reconstruction and supporting natural healing processes. In conclusion, further advances of tissue-engineered reconstruction need multidisciplinary research to create complex tissue structures and make satisfactory outcomes clinically achievable for most patients. This review highlights clinical advances in the field and gives an overview about current scientific concepts. PMID:22421853

Schantz, Jan-Thorsten; Machens, Hans-Günther; Schilling, Arndt F; Teoh, Swee-Hin

2012-03-01

206

Liposomes in tissue engineering and regenerative medicine  

PubMed Central

Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches. PMID:25401172

Monteiro, Nelson; Martins, Albino; Reis, Rui L.; Neves, Nuno M.

2014-01-01

207

Regenerative Blower for EVA Suit Ventilation Fan  

NASA Technical Reports Server (NTRS)

Portable life support systems in future space suits will include a ventilation subsystem driven by a dedicated fan. This ventilation fan must meet challenging requirements for pressure rise, flow rate, efficiency, size, safety, and reliability. This paper describes research and development that showed the feasibility of a regenerative blower that is uniquely suited to meet these requirements. We proved feasibility through component tests, blower tests, and design analysis. Based on the requirements for the Constellation Space Suit ventilation fan, we designed the critical elements of the blower. We measured the effects of key design parameters on blower performance using separate effects tests, and used the results of these tests to design a regenerative blower that will meet the ventilation fan requirements. We assembled a proof-of-concept blower and measured its performance at low pressures that simulate a PLSS environment. We obtained head/flow performance curves over a range of operating speeds, identified the maximum efficiency point for the blower, and used these results to specify the design and operating conditions for the ventilation fan. We designed a compact motor that can drive the blower under all anticipated operating requirements and operate with high efficiency during normal operation. We identified materials for the blower that will enhance safety for operation in a lunar environment. We produced a solid model that illustrates the final design. The proof-of-concept blower produced the flow rate and pressure rise needed for the CSSS ventilation subsystem while running at 5400 rpm and consuming only 9 W of electric power and using a non-optimized, commercial motor and controller and inefficient bearings. Scaling the test results to a complete design shows that a lightweight, compact, reliable, and low power blower can meet the performance requirements for future PLSSs.

Paul, Heather; Izenson, Mike; Chen, Weibo

2008-01-01

208

Power Management in Regenerative Life Support Systems  

NASA Technical Reports Server (NTRS)

Effective management of power can reduce the cost of launch and operation of regenerative life support systems. Variations in power may be quite severe and may manifest as surges or spikes, While the power plant may have some ability to deal with these variations, with batteries for example, over-capacity is expensive and does nothing to address the fundamental issue of excessive demand. Because the power unit must be sized to accommodate the largest demand, avoiding power spikes has the potential to reduce the required size of the power plant while at the same time increasing the dependability of the system. Scheduling of processors can help to reduce potential power spikes. However, not all power-consuming equipment is easily scheduled. Therefore, active power management is needed to further decrease the risk of surges or spikes. We investigate the use of a hierarchical scheme to actively manage power for a model of a regenerative life support system. Local level controllers individually determine subsystem power usage. A higher level controller monitors overall system power and detects surges or spikes. When a surge condition is detected, the higher level controller conducts an 'auction' and describes subsystem power usage to re-allocate power. The result is an overall reduction in total power during a power surge. The auction involves each subsystem making a 'bid' to buy or sell power based on local needs. However, this re-allocation cannot come at the expense of life support function. To this end, participation in the auction is restricted to those processes meeting certain tolerance constraints. These tolerances represent acceptable limits within which system processes can be operated. We present a simulation model and discuss some of our results.

Crawford, Sekou; Pawlowski, Christopher; Finn, Cory; Mead, Susan C. (Technical Monitor)

1999-01-01

209

Heat cascading regenerative sorption heat pump  

NASA Technical Reports Server (NTRS)

A simple heat cascading regenerative sorption heat pump process with rejected or waste heat from a higher temperature chemisorption circuit (HTCC) powering a lower temperature physisorption circuit (LTPC) which provides a 30% total improvement over simple regenerative physisorption compression heat pumps when ammonia is both the chemisorbate and physisorbate, and a total improvement of 50% or more for LTPC having two pressure stages. The HTCC contains ammonia and a chemisorbent therefor contained in a plurality of canisters, a condenser-evaporator-radiator system, and a heater, operatively connected together. The LTPC contains ammonia and a physisorbent therefor contained in a plurality of compressors, a condenser-evaporator-radiator system, operatively connected together. A closed heat transfer circuit (CHTC) is provided which contains a flowing heat transfer liquid (FHTL) in thermal communication with each canister and each compressor for cascading heat from the HTCC to the LTPC. Heat is regenerated within the LTPC by transferring heat from one compressor to another. In one embodiment the regeneration is performed by another CHTC containing another FHTL in thermal communication with each compressor. In another embodiment the HTCC powers a lower temperature ammonia water absorption circuit (LTAWAC) which contains a generator-absorber system containing the absorbent, and a condenser-evaporator-radiator system, operatively connected together. The absorbent is water or an absorbent aqueous solution. A CHTC is provided which contains a FHTL in thermal communication with the generator for cascading heat from the HTCC to the LTAWAC. Heat is regenerated within the LTAWAC by transferring heat from the generator to the absorber. The chemical composition of the chemisorbent is different than the chemical composition of the physisorbent, and the absorbent. The chemical composition of the FHTL is different than the chemisorbent, the physisorbent, the absorbent, and ammonia.

Jones, Jack A. (Inventor)

1995-01-01

210

The TMI Regenerative Solid Oxide Fuel Cell  

NASA Technical Reports Server (NTRS)

Energy storage and production in space requires rugged, reliable hardware which minimizes weight, volume, and maintenance while maximizing power output and usable energy storage. Systems generally consist of photovoltaic solar arrays which operate (during sunlight cycles) to provide system power and regenerate fuel (hydrogen) via water electrolysis and (during dark cycles) fuel cells convert hydrogen into electricity. Common configurations use two separate systems (fuel cell and electrolyzer) in conjunction with photovoltaic cells. Reliability, power to weight and power to volume ratios could be greatly improved if both power production (fuel cells) and power storage (electrolysis) functions can be integrated into a single unit. The solid oxide fuel cell (SOFC) based design integrates fuel cell and electrolyzer functions and potentially simplifies system requirements. The integrated fuel cell/electrolyzer design also utilizes innovative gas storage concepts and operates like a rechargeable 'hydrogen-oxygen battery'. Preliminary research has been completed on improved H2/H20 electrode (SOFC anode/electrolyzer cathode) materials for regenerative fuel cells. Tests have shown improved cell performance in both fuel and electrolysis modes in reversible fuel cell tests. Regenerative fuel cell efficiencies, ratio of power out (fuel cell mode) to power in (electrolyzer mode), improved from 50 percent using conventional electrode materials to over 80 percent. The new materials will allow a single SOFC system to operate as both the electolyzer and fuel cell. Preliminary system designs have also been developed to show the technical feasibility of using the design for space applications requiring high energy storage efficiencies and high specific energy. Small space systems also have potential for dual-use, terrestrial applications.

Cable, Thomas L.; Ruhl, Robert C.; Petrik, Michael

1996-01-01

211

Regenerative PN ranging experience with New Horizons during 2012  

NASA Astrophysics Data System (ADS)

The New Horizons mission to Pluto is the first deep space mission to include the capability of supporting regenerative PN ranging. During the current phase of the mission, sequential tone ranging supports the mission navigation requirements but regenerative ranging will expand the conditions (antenna selection, integration time, etc.) over which ranging will be successful during any extended mission following the Pluto fly-by, to objects in the Kuiper belt. Experience with regenerative ranging is being obtained now in preparation for its use in an extended mission. During most of 2012, New Horizons was in a hibernation state. Tracking was conducted between late April and early July. Six regenerative ranging passes were performed to bookend this interval; 2 at the beginning and 4 at the end. During that time, the distance between the spacecraft and Earth was in excess of 22 Astronautical Units (AU) and the Pr/No levels were below 15 dB-Hz. A seventh regenerative ranging pass was performed in May at a higher signal level in order to test the acquisition of the ranging code by the spacecraft during a variety of conditions. The consistency of the regenerative range measurements with the adjacent sequential tone ranging measurements has been demonstrated and serves as a check on the calibration of the regenerative ranging system conditions. The range measurement precision has been shown to follow the predictions that are based on the uplink and downlink signal power. The regenerative ranging system has been shown to acquire the uplink ranging code with and without a commanded reset and regardless of the noise bandwidth setting of the system. This paper will present the data that was obtained during 2012 and will describe the analysis results for the regenerative ranging experience during 2012.

Jensen, J. R.; Haskins, C. B.; DeBoy, C. C.

212

Analysis of arterial intimal hyperplasia: review and hypothesis  

PubMed Central

Background Despite a prodigious investment of funds, we cannot treat or prevent arteriosclerosis and restenosis, particularly its major pathology, arterial intimal hyperplasia. A cornerstone question lies behind all approaches to the disease: what causes the pathology? Hypothesis I argue that the question itself is misplaced because it implies that intimal hyperplasia is a novel pathological phenomenon caused by new mechanisms. A simple inquiry into arterial morphology shows the opposite is true. The normal multi-layer cellular organization of the tunica intima is identical to that of diseased hyperplasia; it is the standard arterial system design in all placentals at least as large as rabbits, including humans. Formed initially as one-layer endothelium lining, this phenotype can either be maintained or differentiate into a normal multi-layer cellular lining, so striking in its resemblance to diseased hyperplasia that we have to name it "benign intimal hyperplasia". However, normal or "benign" intimal hyperplasia, although microscopically identical to pathology, is a controllable phenotype that rarely compromises blood supply. It is remarkable that each human heart has coronary arteries in which a single-layer endothelium differentiates early in life to form a multi-layer intimal hyperplasia and then continues to self-renew in a controlled manner throughout life, relatively rarely compromising the blood supply to the heart, causing complications requiring intervention only in a small fraction of the population, while all humans are carriers of benign hyperplasia. Unfortunately, this fundamental fact has not been widely appreciated in arteriosclerosis research and medical education, which continue to operate on the assumption that the normal arterial intima is always an "ideal" single-layer endothelium. As a result, the disease is perceived and studied as a new pathological event caused by new mechanisms. The discovery that normal coronary arteries are morphologically indistinguishable from deadly coronary arteriosclerosis continues to elicit surprise. Conclusion Two questions should inform the priorities of our research: (1) what controls switch the single cell-layer intimal phenotype into normal hyperplasia? (2) how is normal (benign) hyperplasia maintained? We would be hard-pressed to gain practical insights without scrutinizing our premises. PMID:17974015

2007-01-01

213

Adaptive controller for regenerative and friction braking system  

DOEpatents

A regenerative and friction braking system for a vehicle having one or more roadwheels driven by an electric traction motor includes a driver responsive device for producing a brake demand signal having a magnitude corresponding to the level of braking force selected by the driver and friction and regenerative brakes operatively connected with the roadwheels of the vehicle. A system according to this invention further includes control means for operating the friction and regenerative braking subsystems so that maximum brake torques sustainable by the roadwheels of the vehicle without skidding or slipping will not be exceeded.

Davis, Roy I. (Ypsilanti, MI)

1990-01-01

214

Adaptive controller for regenerative and friction braking system  

DOEpatents

A regenerative and friction braking system for a vehicle having one or more road wheels driven by an electric traction motor includes a driver responsive device for producing a brake demand signal having a magnitude corresponding to the level of braking force selected by the driver and friction and regenerative brakes operatively connected with the road wheels of the vehicle. A system according to this invention further includes control means for operating the friction and regenerative braking subsystems so that maximum brake torques sustainable by the road wheels of the vehicle without skidding or slipping will not be exceeded. 8 figs.

Davis, R.I.

1990-10-16

215

Nanog induces hyperplasia without initiating tumors.  

PubMed

Though expression of the homeobox transcription factor Nanog is generally restricted to pluripotent cells and early germ cells, many contradictory reports about Nanog's involvement in tumorigenesis exist. To address this, a modified Tet-On system was utilized to generate Nanog-inducible mice. Following prolonged Nanog expression, phenotypic alterations were found to be restricted to the intestinal tract, leaving other major organs unaffected. Intestinal and colonic epithelium hyperplasia was observed-intestinal villi had doubled in length and hyperplastic epithelium outgrowths were seen after 7days. Increased proliferation of crypt cells and downregulation of the tumor suppressors Cdx2 and Klf4 was detected. ChIP analysis showed physical interaction of Nanog with the Cdx2 and Klf4 promoters, indicating a regulatory conservation from embryonic development. Despite downregulation of tumor suppressors and increased proliferation, ectopic Nanog expression did not lead to tumor formation. We conclude that unlike other pluripotency-related transcription factors, Nanog cannot be considered an oncogene. PMID:25173648

Fischedick, Gerrit; Wu, Guangming; Adachi, Kenjiro; Araúzo-Bravo, Marcos J; Greber, Boris; Radstaak, Martina; Köhler, Gabriele; Tapia, Natalia; Iacone, Roberto; Anastassiadis, Konstantinos; Schöler, Hans R; Zaehres, Holm

2014-09-01

216

Conjunctival lymphoma arising from reactive lymphoid hyperplasia.  

PubMed

Extra nodal marginal zone B-cell lymphoma (EMZL) of the conjunctiva typically arises in the marginal zone of mucosa-associated lymphoid tissue. The pathogenesis of conjunctival EMZL remains unknown. We describe an unusual case of EMZL arising from reactive lymphoid hyperplasia (RLH) of the conjunctiva. A 35-year-old woman had fleshy salmon-pink conjunctival tumors in both eyes, oculus uterque (OU). Specimens from conjunctival tumors in the right eye, oculus dexter (OD), revealed a collection of small lymphoid cells in the stroma. Immunohistochemically, immunoglobulin (Ig) light chain restriction was not detected. In contrast, diffuse atypical lymphoid cell infiltration was noted in the left eye, oculus sinister (OS), and positive for CD20, a marker for B cells OS. The tumors were histologically diagnosed as RLH OD, and EMZL OS. PCR analysis detected IgH gene rearrangement in the joining region (JH) region OU. After 11 months, a re-biopsy specimen demonstrated EMZL based on compatible pathological and genetic findings OD, arising from RLH. This case suggests that even if the diagnosis of the conjunctival lymphoproliferative lesions is histologically benign, confirmation of the B-cell clonality by checking IgH gene rearrangement should be useful to predict the incidence of malignancy. PMID:22985187

Fukuhara, Junichi; Kase, Satoru; Noda, Mika; Ishijima, Kan; Yamamoto, Teppei; Ishida, Susumu

2012-01-01

217

A Case of Congenital Lipoid Adrenal Hyperplasia  

PubMed Central

Lipoid congenital adrenal hyperplasia (lipoid CAH), a rare disorder of steroid biosynthesis, is the most severe form of CAH. In this disorder the synthesis of glucocorticoids, mineralocorticoids and sex steroids is impaired which result in adrenal failure, severe salt wasting crisis and hyperpigmentation in phenotypical female infants irrespective of genetic sex. In this report, we presented a 28-day-old phenotypic female infant, which referred with lethargy, failure to thrive and electrolyte abnormalities. Considering the clinical and biochemical findings, lipoid CAH was diagnosed and replacement therapy with standard doses of glucocorticoid and mineralocorticoid and sodium chloride was initiated. During follow-up, she had good clinical condition, but at 6 years of age, she refers with hypertension and adrenal insufficiency because of arbitrary drug discontinuation by mother. In ultrasonography an abdominal mass (the testicles) was reported. Chromosome study showed 46XY pattern. Orchiectomy was performed. We recommended that in cases with clinical presentation of adrenal insufficiency if there is not the facility to determine the karyotype, repeated ultrasonography perform during follow-up. In addition, investigating the genetic bases of the disorder would help us to determine the pathogenesis of lipoid CAH in our community. It would be helpful in prenatal diagnosis and treatment of the disorder to prevent its related comorbidities. PMID:22891154

Hashemipour, Mahin; Ghasemi, Mahmoud; Hovsepian, Silva

2012-01-01

218

Benign Prostatic Hyperplasia: from Bench to Clinic  

PubMed Central

Benign prostatic hyperplasia (BPH) is a prevalent disease, especially in old men, and often results in lower urinary tract symptoms (LUTS). This chronic disease has important care implications and financial risks to the health care system. LUTS are caused not only by mechanical prostatic obstruction but also by the dynamic component of obstruction. The exact etiology of BPH and its consequences, benign prostatic enlargement and benign prostatic obstruction, are not identified. Various theories concerning the causes of benign prostate enlargement and LUTS, such as metabolic syndrome, inflammation, growth factors, androgen receptor, epithelial-stromal interaction, and lifestyle, are discussed. Incomplete overlap of prostatic enlargement with symptoms and obstruction encourages focus on symptoms rather than prostate enlargement and the shifting from surgery to medicine as the treatment of BPH. Several alpha antagonists, including alfuzosin, doxazosin, tamsulosin, and terazosin, have shown excellent efficacy without severe adverse effects. In addition, new alpha antagonists, silodosin and naftopidil, and phosphodiesterase 5 inhibitors are emerging as BPH treatments. In surgical treatment, laser surgery such as photoselective vaporization of the prostate and holmium laser prostatectomy have been introduced to reduce complications and are used as alternatives to transurethral resection of the prostate (TURP) and open prostatectomy. The status of TURP as the gold standard treatment of BPH is still evolving. We review several preclinical and clinical studies about the etiology of BPH and treatment options. PMID:22468207

Cho, Hee Ju

2012-01-01

219

Radiation-pressure-induced regenerative mechanical oscillations in  

E-print Network

-Pressure Induced Mechanical Oscillation of an optical Microcavity" Physical Review Letters, Volume 95, 033901, JulyRadiation-pressure-induced regenerative mechanical oscillations in optical microcavities Hossein Physics Department California Institute of Technology APS March meeting 2006 #12;Microtoroid optical

220

The economic value of investing in regenerative medicine.  

PubMed

This article discusses the science of regenerative medicine and presents evidence that investments towards the development of this technology will reduce total health care output. Use of regenerative medicine will also be an important factor in eliminating chronic diseases such as diabetes, heart disease, and Parkinson's disease. Investment in regenerative medicine is a sound strategy for several reasons: human suffering will be reduced, if not eliminated; and the economy will be stimulated by creating employment opportunities, generating additional income and tax revenues, increasing worker productivity, creating new conglomerates, and reducing insurance costs. This article discusses some of the latest advances in regenerative medicine as well as the progress that has been made in the development of new stem cell therapies. PMID:20499720

Hussain, Aftab; Rivers, Patrick A

2009-01-01

221

Regenerative fuel cell combines high efficiency with low cost  

NASA Technical Reports Server (NTRS)

Hydrogen/oxygen regenerative fuel cell stores electrical energy efficiently and inexpensively. The fuel cell has a high energy-to-weight ratio, and is adapted for a large number of cycles with deep discharge.

Doyle, H.; Frank, H.; Stephens, C. W.

1965-01-01

222

New Regenerative Cycle for Vapor Compression Refrigeration  

SciTech Connect

The main objective of this project is to confirm on a well-instrumented prototype the theoretically derived claims of higher efficiency and coefficient of performance for geothermal heat pumps based on a new regenerative thermodynamic cycle as comparing to existing technology. In order to demonstrate the improved performance of the prototype, it will be compared to published parameters of commercially available geothermal heat pumps manufactured by US and foreign companies. Other objectives are to optimize the design parameters and to determine the economic viability of the new technology. Background (as stated in the proposal): The proposed technology closely relates to EERE mission by improving energy efficiency, bringing clean, reliable and affordable heating and cooling to the residential and commercial buildings and reducing greenhouse gases emission. It can provide the same amount of heating and cooling with considerably less use of electrical energy and consequently has a potential of reducing our nations dependence on foreign oil. The theoretical basis for the proposed thermodynamic cycle was previously developed and was originally called a dynamic equilibrium method. This theory considers the dynamic equations of state of the working fluid and proposes the methods for modification of T-S trajectories of adiabatic transformation by changing dynamic properties of gas, such as flow rate, speed and acceleration. The substance of this proposal is a thermodynamic cycle characterized by the regenerative use of the potential energy of two-phase flow expansion, which in traditional systems is lost in expansion valves. The essential new features of the process are: (1) The application of two-step throttling of the working fluid and two-step compression of its vapor phase. (2) Use of a compressor as the initial step compression and a jet device as a second step, where throttling and compression are combined. (3) Controlled ratio of a working fluid at the first and second step of compression. In the proposed system, the compressor compresses the vapor only to 50-60% of the final pressure, while the additional compression is provided by a jet device using internal potential energy of the working fluid flow. Therefore, the amount of mechanical energy required by a compressor is significantly reduced, resulting in the increase of efficiency (either COP or EER). The novelty of the cycle is in the equipment and in the way the multi-staging is accomplished. The anticipated result will be a new refrigeration system that requires less energy to accomplish a cooling task. The application of this technology will be for more efficient designs of: (1) Industrial chillers, (2) Refrigeration plants, (3) Heat pumps, (4) Gas Liquefaction plants, (5) Cryogenic systems.

Mark J. Bergander

2005-08-29

223

Regenerative Markov Chain Monte Carlo for any distribution.  

SciTech Connect

While Markov chain Monte Carlo (MCMC) methods are frequently used for difficult calculations in a wide range of scientific disciplines, they suffer from a serious limitation: their samples are not independent and identically distributed. Consequently, estimates of expectations are biased if the initial value of the chain is not drawn from the target distribution. Regenerative simulation provides an elegant solution to this problem. In this article, we propose a simple regenerative MCMC algorithm to generate variates for any distribution

Minh, D. (Biosciences Division); (California State Univ.)

2012-01-01

224

Physiological regeneration of skin appendages and implications for regenerative medicine  

PubMed Central

The concept of regenerative medicine is relatively new, but animals are well known to remake their hair and feathers regularly by normal regenerative physiological processes. Here we focus on 1) how extra-follicular environments can regulate hair and feather stem cell activities and 2) how different configurations of stem cells can shape organ forms in different body regions to fulfil changing physiological needs. PMID:22505663

Chuong, Cheng-Ming; Randall, Valerie A; Widelitz, Randall B.; Wu, Ping; Jiang, Ting-Xin

2013-01-01

225

An examination of regenerative organic Rankine cycles using dry fluids  

Microsoft Academic Search

This paper presents an analysis of regenerative organic Rankine cycles “ORC” using dry organic fluids, to convert waste energy to power from low-grade heat sources. The dry organic working fluids selected for this investigation are R113, R245ca, R123, and isobutane, with boiling points ranging from ?12°C to 48°C. Regenerative ORC is analyzed and compared with the basic ORC in order

Pedro J. Mago; Louay M. Chamra; Kalyan Srinivasan; Chandramohan Somayaji

2008-01-01

226

[Angiolymphoid hyperplasia with eosinophilia or Kimura disease?].  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimur's disease are two rarely occurring and mutually very similar, yet independent nosological units. For the frequency of similar features these diseases were long considered to be modifications of one disease. In the last years most authors considered these diseases to be independent entities with certain specific clinical and morphological features. The case of a 76-year white man, suffering from occurrence of subcutaneous tumor formations in various part of the body for the period of six years, is described. Six years after the first signs of the disease, swelling of eyelids on the right eye with palpable resistance under the upper temporal margin of eye socket developed. A similar finding also developed on the left side eight months later. The tumors were removed by surgery and subjected to histological examination. One year later a unilateral relapse developed to be again subjected to surgical treatment and histological examination. In the first two orbital excisions the tumor infiltrate was in topical connection with structure of the tear gland, the third excision did not contain such structures. The histological diagnosis was established as ALHE in spite of some common features with the Kimur's disease. The diagnosis of ALHE was especially supported by absence of the formation of lymphatic follicles, absent fibrotization in the infiltrate and epithelium-like or even histiocyte-like appearance of proliferating endothelia, which formed minute vascular lumina. A substantial exceptionality in the occurrence of the Kimur's disease in white Europeans further supported the diagnosis of ALHE. Our own experience indicates that both units mutually overlap even in features considered to be of distinctly different character. A question arises, whether the strict division of these two nosological units is really possible in practice with unequivocal certainty. PMID:14518359

Baráková, D; Sach, J; Krásný, J; Kuchynka, P; Redinová, M; Kodat, V

2003-09-01

227

Prenatal treatment of congenital adrenal hyperplasia.  

PubMed

In foetuses at risk of virilising congenital adrenal hyperplasia (CAH), prenatal treatment can be offered by administration of dexamethasone (DEX) via the mother, in order to suppress foetal adrenal androgen oversecretion and prevent genital malformations. The first treated cases were described 20 years ago, and several hundred pregnancies have been reported since. There is a consensus that the treatment effectively prevents or reduces virilisation, but opinions regarding its safety differ. Rare adverse events have been reported in treated children, but no harmful effect has been documented that can be clearly attributed to the treatment. However, few treated foetuses have been followed until adolescence. Animal studies and epidemiological data point to various adverse effects of excess glucocorticoids on the developing foetus. In order to prevent virilisation effectively in females affected with CAH, the prenatal treatment needs to be instituted in the early first trimester, before prenatal diagnosis is possible. Thus, a majority of treated foetuses will receive DEX unnecessarily. The PREDEX study was initiated in Stockholm in 1999 as an open, controlled, non-randomised, multicentre trial. Participating centres are Stockholm, Bergen, Kuopio, Warsaw, London, Lyon and Barcelona. The study has been approved by the ethics committees in each country. The purpose of PREDEX is to evaluate prospectively the prenatal treatment regarding efficacy in preventing virilisation as well as to study its safety for both mothers and treated children. Children are followed until 18 years of age and a wide range of physiological, metabolic and developmental parameters are considered. In Sweden, treatment is not offered outside the frames of the trial. PMID:15554888

Lajic, Svetlana; Nordenström, Anna; Ritzén, E Martin; Wedell, Anna

2004-11-01

228

Benign prostatic hyperplasia: pathogenesis and medical therapy.  

PubMed

Epidemiologic studies in castrates strongly support the key role of the testis in the pathogenesis of benign prostatic hyperplasia (BPH). Since the testis secretes androgen and estrogen, both of these hormones have been implicated in BPH. Much information supports the important role of dihydrotestosterone (DHT) in BPH, including intraprostatic activities of enzymes that regulate DHT. Although controversy still exists, DHT levels in BPH may be higher than in normal prostate tissue. Based upon these findings and the ability to quantitate prostate size and function with reliable new techniques, suppression of androgen-mediated action has been tested to assess the validity of the DHT theory. A variety of drugs has been demonstrated to decrease prostate size by approximately 30% by either blocking secretion of circulating testosterone and adrenal androgen, inhibiting 5 alpha-reductase to prevent DHT formation, or blocking DHT binding to androgen receptors. Accompanying these changes in size was significant improvement in clinical symptoms of prostatism in about 50% of patients, when double-blind, large multicenter studies were conducted with one of these drugs. Although these results suggest a very important role for androgen, particularly DHT, in the pathogenesis of BPH, other abnormalities may coexist since significant numbers of patients do not show a total reversal of disease. There is strong indirect evidence for a possible role for estrogen in the pathogenesis of BPH, and studies are under way to test the effects of estrogen withdrawal on prostate size and symptoms. Similarly, dynamic aspects of prostatic obstruction, which are under alpha-adrenergic regulation, may also be a component of this disease and amenable to therapy with alpha-adrenergic blockers.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1720438

Geller, J

1991-12-01

229

Laparoscopic Adrenalectomy for Nonfamilial Adrenal Medullary Hyperplasia  

PubMed Central

Background and Objectives: Sporadic adrenomedullary hyperplasia (AMH) is characterized by a medical history of hypertension, excessive catecholamine excretion, and histomorphometric evidence of increased adrenomedullary tissue relative to the cortex in the absence of multiple endocrine neoplasia. The aim of this study was to perform a retrospective analysis of patients after laparoscopic adrenalectomy for AMH, an early form of sporadic adrenal medulla–related endocrine hypertension, as well as to update our understanding of the clinical features and management of this clinicomorphologic entity. Methods: We performed a retrospective review of the medical records of patients operated on between 2007 and 2011 at Reina Sofia University General Hospital, Murcia, Spain, with a diagnosis of AMH. Patient characteristics, diagnostic studies, surgical procedures, and histologic findings were analyzed. Results: Seven hypertensive patients with intermittent adrenergic crises were found to have AMH (3 men and 4 women; mean age, 44 years). Catecholamine levels were increased. Radiologic studies included 1 or more of the following: magnetic resonance imaging, computed tomography, positron emission tomography imaging with fluorodeoxyglucose, dihydroxyphenylalanine–positron emission tomography–computed tomography, Octreoscan (Mallinckrodt Pharmaceuticals, St. Louis, MO, USA) and 123I-metaiodobenzylguanidine scintigraphy. Laparoscopic adrenalectomy was performed in all cases. One patient underwent bilateral adrenalectomy because of persistent symptomatology after unilateral adrenalectomy. Surgery was associated with normalization of catecholamine hypersecretion and complete disappearance of symptoms, as well as the reduction or abstention of antihypertensive therapy. Conclusions: Sporadic AMH is a clinicomorphologic entity that may mimic pheochromocytoma clinically. Recent advances in diagnostic and surgical methods have changed the management and outcome of this unusual disease. Laparoscopic adrenalectomy may be recommended as the gold standard in the treatment of this entity. Definitive diagnosis is provided by histologic study. PMID:24018082

Candel Arenas, Maria Fe; González Valverde, Francisco Miguel; Terol Garaulet, Emilio; Maestre Maderuelo, María; Meoro Avilés, Amparo; Pastor Quirante, Francisco; Albarracín Marín Blázquez, Antonio

2013-01-01

230

Current Laser Treatments for Benign Prostatic Hyperplasia  

PubMed Central

The latest technical improvements in the surgical armamentarium are remarkable. In particular, advancements in the urologic field are so exceptional that we could observe the flare-up of robot-assisted laparoscopic radical prostatectomy for prostate cancer and laser prostatectomy for benign prostatic hyperplasia (BPH). Photoselective vaporization of the prostate (PVP) and holmium laser prostatectomy are the most generalized options for laser surgery of BPH, and both modalities have shown good postoperative results. In comparison to transurethral prostatectomy (TURP), they showed similar efficacy and a much lower complication rate in randomized prospective clinical trials. Even in cases of large prostates, laser prostatectomy showed comparable efficacy and safety profiles compared to open prostatectomy. From a technical point of view, PVP is considered to be an easier technique for the urologist to master. Furthermore, patients can be safely followed up in an outpatient clinic. Holmium laser enucleation of the prostate (HoLEP) mimics open prostatectomy because the adenomatous tissue is peeled off the surgical capsule in both procedures. Therefore, HoLEP shows notable volume reduction of the prostate similar to open prostatectomy with fewer blood transfusions, shorter hospital stay, and cost reduction regardless of prostate size. Outcomes of laser prostatectomy for BPH are encouraging but sometimes are unbalanced because safety and feasibility studies were reported mainly for PVP, whereas long-term data are mostly available for HoLEP. We need longer-term randomized clinical data to identify the reoperation rate of PVP and to determine which procedure is the ideal alternative to TURP and open prostatectomy for each patient. PMID:21165192

Son, Hwancheol; Song, Sang Hoon

2010-01-01

231

AB 32. Pulmonary nodular lymphoid hyperplasia. Case report  

PubMed Central

Background Nodular lymphoid hyperplasia is considered to represent a localized form of lymphoid hyperplasia, which presents as a discreet pulmonary mass or masses Median age of diagnosis are 65 years (range, 19-80 years). Chest X-ray and CT scan show an isolated mass (64%) or multiple nodules (36%). Hilar or mediastinal adenopathy may be present is some patients. Patients and methods We describe the case of nodular lymphoid hyperplasia in a 52 year-old woman who presented with pulmonary multiple nodules, bilateral and mediastinal adenopathy, apparent by chest X-ray and CT-scan. Open biopsy was performed from the upper and down lobe of the right lung and from the mediastinal lymph nodes. Macroscopic examination revealed small white nodules, measuring 0.3 to 0.7 cm in maximum diameter. The sections were examined with H+E and followed by immunohistochemical study. Results Histological examination revealed multiple well demarcated nodules consisting of aggregates of lymphoid follicles and sheets of interfollicular small lymphocytes and plasma cells. Lymphoepithelial lesions were absent. The immunohistochemical stains for lymphoid markers were consistent with a reactive process. Bcl-2 protein expression was absent in germinal centers, but presented in the mantle zone and interfollicular T-cells. Similar were the immunohistochemical findings of the lymph nodes study. Conclusions Nodular lymphoid hyperplasia is a benign lesion, although surgical excision is usually needed to allow correct diagnosis. The main entity in the differential diagnosis of nodular lymphoid hyperplasia is BALT lymphoma.

Papaemmanouil, Stiliani; Iordanidis, Fotis; Moraitis, Dimitrios; Sakkas, Leonidas

2012-01-01

232

From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells  

PubMed Central

Adult mesenchymal stem cells (MSCs) and epithelial stem cells play essential roles in tissue repair and self-healing. Oral MSCs and epithelial stem cells can be isolated from adult human oral tissues, for example, teeth, periodontal ligament, and gingiva. Cocultivated adult oral epithelial stem cells and MSCs could represent some developmental events, such as epithelial invagination and tubular structure formation, signifying their potentials for tissue regeneration. Oral epithelial stem cells have been used in regenerative medicine over 1 decade. They are able to form a stratified cell sheet under three-dimensional culture conditions. Both experimental and clinical data indicate that the cell sheets can not only safely and effectively reconstruct the damaged cornea in humans, but also repair esophageal ulcer in animal models. Oral MSCs include dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), stem cells from apical papilla (SCAP), periodontal ligament stem cells (PDLSCs), and mesenchymal stem cells from gingiva (GMSCs). They are widely applied in both regenerative dentistry and medicine. DPSCs, SHED, and SCAP are able to form dentin–pulp complex when being transplanted into immunodeficient animals. They have been experimentally used for the regeneration of dental pulp, neuron, bone muscle and blood vessels in animal models and have shown promising results. PDLSCs and GMSCs are demonstrated to be ideal cell sources for repairing the damaged tissues of periodontal, muscle, and tendon. Despite the abovementioned applications of oral stem cells, only a few human clinical trials are now underway to use them for the treatment of certain diseases. Since clinical use is the end goal, their true regenerative power and safety need to be further examined. PMID:25506228

Xiao, Li; Nasu, Masanori

2014-01-01

233

REGENERATIVE MEDICINE AS APPLIED TO GENERAL SURGERY  

PubMed Central

The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues or organs in order to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate. PMID:22330032

Orlando, Giuseppe; Wood, Kathryn J; De Coppi, Paolo; Baptista, Pedro M; Binder, Kyle W; Bitar, Khalil N; Breuer, Christopher; Burnett, Luke; Christ, George; Farney, Alan; Figliuzzi, Marina; Holmes, James H; Koch, Kenneth; Macchiarini, Paolo; Sani, Sayed-Hadi Mirmalek; Opara, Emmanuel; Remuzzi, Andrea; Rogers, Jeffrey; Saul, Justin M; Seliktar, Dror; Shapira-Schweitzer, Keren; Smith, Tom; Solomon, Daniel; Van Dyke, Mark; Yoo, James J; Zhang, Yuanyuan; Atala, Anthony; Stratta, Robert J; Soker, Shay

2012-01-01

234

High power, high beam quality regenerative amplifier  

DOEpatents

A regenerative laser amplifier system generates high peak power and high energy per pulse output beams enabling generation of X-rays used in X-ray lithography for manufacturing integrated circuits. The laser amplifier includes a ring shaped optical path with a limited number of components including a polarizer, a passive 90 degree phase rotator, a plurality of mirrors, a relay telescope, and a gain medium, the components being placed close to the image plane of the relay telescope to reduce diffraction or phase perturbations in order to limit high peak intensity spiking. In the ring, the beam makes two passes through the gain medium for each transit of the optical path to increase the amplifier gain to loss ratio. A beam input into the ring makes two passes around the ring, is diverted into an SBS phase conjugator and proceeds out of the SBS phase conjugator back through the ring in an equal but opposite direction for two passes, further reducing phase perturbations. A master oscillator inputs the beam through an isolation cell (Faraday or Pockels) which transmits the beam into the ring without polarization rotation. The isolation cell rotates polarization only in beams proceeding out of the ring to direct the beams out of the amplifier. The diffraction limited quality of the input beam is preserved in the amplifier so that a high power output beam having nearly the same diffraction limited quality is produced.

Hackel, L.A.; Dane, C.B.

1993-08-24

235

High power, high beam quality regenerative amplifier  

DOEpatents

A regenerative laser amplifier system generates high peak power and high energy per pulse output beams enabling generation of X-rays used in X-ray lithography for manufacturing integrated circuits. The laser amplifier includes a ring shaped optical path with a limited number of components including a polarizer, a passive 90 degree phase rotator, a plurality of mirrors, a relay telescope, and a gain medium, the components being placed close to the image plane of the relay telescope to reduce diffraction or phase perturbations in order to limit high peak intensity spiking. In the ring, the beam makes two passes through the gain medium for each transit of the optical path to increase the amplifier gain to loss ratio. A beam input into the ring makes two passes around the ring, is diverted into an SBS phase conjugator and proceeds out of the SBS phase conjugator back through the ring in an equal but opposite direction for two passes, further reducing phase perturbations. A master oscillator inputs the beam through an isolation cell (Faraday or Pockels) which transmits the beam into the ring without polarization rotation. The isolation cell rotates polarization only in beams proceeding out of the ring to direct the beams out of the amplifier. The diffraction limited quality of the input beam is preserved in the amplifier so that a high power output beam having nearly the same diffraction limited quality is produced.

Hackel, Lloyd A. (Livermore, CA); Dane, Clifford B. (Livermore, CA)

1993-01-01

236

Recent advances in acellular regenerative tissue scaffolds.  

PubMed

The management of chronic wounds is a considerable challenge for foot and ankle surgeons. The well-established tenets of adequate vascular supply, debridement with eradication of infection, and offloading must be employed in the management of all extremity wounds. Regenerative scaffolds are a viable means of reestablishing a favorable wound environment. The matrix facilitates cell migration, chemoattraction, angiogenesis, wound bed granulation, and expedited wound closure. Although studies have demonstrated success with acellular matrices, a multimodal approach should always be employed to improve healing success. Negative pressure wound therapy, compression, offloading, and antibiotics are advocated to improve outcomes. Acellular graft selection requires a multifactorial analysis, taking into consideration the specific patient and wound characteristics as well as the differences between acellular matrices. Patient age, comorbidities, activity level, and ability to comply with protocol as well as wound etiology, duration, depth, surface area, exudate, bacterial burden, location, vascular status, ischemic status, and presentation are all critical components. To effectively choose a matrix, the clinician must have a comprehensive understanding of the products available and the data validating their use. The mechanisms by which the acellular matrix accelerates wound healing and increases the likelihood of wound healing continue to be investigated. However, it is clear that these acellular biologic tissue scaffolds are incorporating into the host tissue, with resultant revascularization and cellular repopulation. Moving forward, additional investigations examining the effectiveness of acellular biologic tissue scaffolds to improve healing in complex, nondiabetic wounds are warranted. PMID:25440425

Protzman, Nicole M; Brigido, Stephen A

2015-01-01

237

Unitized Regenerative Fuel Cell System Development  

NASA Technical Reports Server (NTRS)

Unitized Regenerative Fuel Cells (URFC) have recently been developed by several fuel cell manufacturers. These manufacturers have concentrated their efforts on the development of the cell stack technology itself, and have not up to this point devoted much effort to the design and development of the balance of plant. A fuel cell technology program at the Glenn Research Center (GRC) that has as its goal the definition and feasibility testing of the URFC system balance of plant. Besides testing the feasibility, the program also intends to minimize the system weight, volume, and parasitic power as its goal. The design concept currently being developed uses no pumps to circulate coolant or reactants, and minimizes the ancillary components to only the oxygen and hydrogen gas storage tanks, a water storage tank, a loop heat pipe to control the temperature and two pressure control devices to control the cell stack pressures during operation. The information contained in this paper describes the design and operational concepts employed in this concept. The paper also describes the NASA Glenn research program to develop this concept and test its feasibility.

Burke, Kenneth A.

2003-01-01

238

Brushless ultra-efficient regenerative servomechanism  

SciTech Connect

A servomechanism regeneratively controls motion by a brushless coreless axial-field motor, exerting torque thru its permanent-magnet disk rotor, resulting from synchronized polyphase sinusoidal stator currents, controlled by a switching controller responsive to input commands and to Hall-effect transducer signals that vary sinusoidally with rotor angle and respectively correspond to stator phases. The controller operates with a dc power source and sink. Its signal processors derive from the transducer signals instantaneous magnitudes and polarities thereof and continuous lagless speed feedback. The instantaneous magnitudes are multiplied by a torque amplitude signal to provide respective synchronized amplitude control signals. Current transformers having primary windings in series with power switching transistors provide current feedback pulses with amplitude proportional to instaneous current in associated stator windings. Pulse control means initiate bi-phase pulses having restricted duty-cycle, and dictate pulse duration by comparing each current feedback pulse with the associated synchronized amplitude control signal. Switching logic responsive to the bi-phase pulses, to forward and reverse drive and brake commands, and to said polarities, accordingly controls selection and duty-cycle of said power switching transistors which, cooperative with free-wheeling diodes and inductors, effect controlled alternating stator currents.

Fradella, R. B.

1985-05-28

239

Introduction to stem cells and regenerative medicine.  

PubMed

Stem cells are a population of undifferentiated cells characterized by the ability to extensively proliferate (self-renewal), usually arise from a single cell (clonal), and differentiate into different types of cells and tissue (potent). There are several sources of stem cells with varying potencies. Pluripotent cells are embryonic stem cells derived from the inner cell mass of the embryo and induced pluripotent cells are formed following reprogramming of somatic cells. Pluripotent cells can differentiate into tissue from all 3 germ layers (endoderm, mesoderm, and ectoderm). Multipotent stem cells may differentiate into tissue derived from a single germ layer such as mesenchymal stem cells which form adipose tissue, bone, and cartilage. Tissue-resident stem cells are oligopotent since they can form terminally differentiated cells of a specific tissue. Stem cells can be used in cellular therapy to replace damaged cells or to regenerate organs. In addition, stem cells have expanded our understanding of development as well as the pathogenesis of disease. Disease-specific cell lines can also be propagated and used in drug development. Despite the significant advances in stem cell biology, issues such as ethical controversies with embryonic stem cells, tumor formation, and rejection limit their utility. However, many of these limitations are being bypassed and this could lead to major advances in the management of disease. This review is an introduction to the world of stem cells and discusses their definition, origin, and classification, as well as applications of these cells in regenerative medicine. PMID:23257690

Kolios, George; Moodley, Yuben

2013-01-01

240

Regenerative life support system research and concepts  

NASA Technical Reports Server (NTRS)

Life support systems that involve recycling of atmospheres, water, food and waste are so complex that models incorporating all the interactions and relationships are vital to design, development, simulations, and ultimately to control of space qualified systems. During early modeling studies, FORTRAN and BASIC programs were used to obtain numerical comparisons of the performance of different regenerative concepts. Recently, models were made by combining existing capabilities with expert systems to establish an Intelligent Design Support Environment for simpliflying user interfaces and to address the need for the engineering aspects. Progress was also made toward modeling and evaluating the operational aspects of closed loop life support systems using Time-step and Dynamic simulations over a period of time. Example models are presented which show the status and potential of developed modeling techniques. For instance, closed loop systems involving algae systeMs for atmospheric purification and food supply augmentation, plus models employing high plants and solid waste electrolysis are described and results of initial evaluations are presented.

1988-01-01

241

Regenerative processes in supercooled liquids and glasses  

NASA Astrophysics Data System (ADS)

The mode-coupling equations used to study glasses and supercooled liquids define the underlying regenerative processes represented by an indicator function Z( t). Such a process is a special case of an alternating renewal process, and it introduces in a natural way a stochastic two level system. In terms of the fundamental Z-process one can define several other processes, such as a local time process H(t)= limit?0tZ(u) du and its inverse process T(t)= sup{u : H(u)?t} . At the critical point Tc these processes have ergodic limits when t?? given by the stable additive process Ya( t) and its inverse process Xa( t), where a is the critical exponent. These processes are selfsimilar, and the latter is given by the Mittag-Leffler distribution. The appearance of these limit processes, which is a consequence of the Darling-Kac theorem, is the generic reason for the universal predictions of the mode-coupling theory, and are observed in many glassforming systems. We also find a similar behaviour for the ?-relaxation function but for the initial behaviour at t?0, and the limit processes are in this case given by Y1- b and X1- b, where b is the von Schweidler exponent. This also implies that the relaxation function belongs to the domain of attraction of the stable distribution with the characteristic function exp(- tb).

Sjögren, L.

2003-05-01

242

77H.S. Bernstein (ed.), Tissue Engineering in Regenerative Medicine, Stem Cell Biology and Regenerative Medicine, DOI 10.1007/978-1-61779-322-6_5,  

E-print Network

77H.S. Bernstein (ed.), Tissue Engineering in Regenerative Medicine, Stem Cell Biology and Regenerative Medicine, DOI 10.1007/978-1-61779-322-6_5, © Springer Science+Business Media, LLC 2011 Abstract for exploitation in the development of regenerative therapies [6, 7]. Coordinated interactions with soluble factors

Parker, Kevin Kit

243

Irradiation for intimal hyperplasia: implications for peripheral arterial bypass.  

PubMed

Irradiation has been shown to inhibit postangioplasty intimal hyperplasia ("restenosis") in unbranched tubes. It seems likely that irradiation will similarly be able to inhibit intimal hyperplasia after a surgical anastomosis at a biochemical and cellular level, but whether it will produce a clinically relevant or even clinically detectable difference is unproved. One possibility is that no clinical effect may occur; the search for a "cure" for intimal hyperplasia has been long and, as yet, unsuccessful. On the other hand, if a strong effect without insurmountable logistical problems could be produced, one major cause of bypass graft failure would be preventable. Not only would the incidence of late graft occlusion, need for reoperation, and limb loss be reduced, but, if patency of prosthetics could be sufficiently improved, the initial operation could be made much easier, faster, and perhaps safer. PMID:10703864

Illig, K A; Soni, A B; Williams, J; Shortell, C K; Okunieff, P; Schell, M; Rubin, P; Green, R M

2000-03-01

244

Treatment of benign lymphoid hyperplasia of the orbit with rituximab.  

PubMed

Benign lymphoid hyperplasia is a disorder characterized by polyclonal lymphocytic infiltration of orbital tissues, predominantly with B-cells. Rituximab is a monoclonal antibody directed against CD20, a B-cell marker. Two patients with recurrent orbital masses involving the lacrimal glands were treated with rituximab. The diagnosis of benign lymphoid hyperplasia with predominance of CD20 cells was confirmed in both cases based on a surgical biopsy. Both patients had been previously treated with standard therapies, including high-dose steroids, and one patient had failed external-beam radiation therapy. They both responded well to treatment with intravenous rituximab. Neither patient experienced any side effects associated with rituximab. PMID:20090476

Ho, Hao H; Savar, Aaron; Samaniego, Felipe; Manning, John; Kasyan, Armen; Pro, Barbara; Esmaeli, Bita

2010-01-01

245

[Intimal hyperplasia within a vascular anastomosis].  

PubMed

Intimal hyperplasia (IH) appears to rank high amongst plausible causes of reconstructed arteries restenosis. It always occurs in the area of a surgical intervention on a vessel in response to a mechanical lesion. IH is the cause of thrombosis in 15 to 50% of cases following vascular reconstruction during the first year after the operation (with the exception of early thromboses, which are probably caused by an improperly performed interventional technique). Of a wide variety of clinical situations leading to development of IH in the vascular wall, for the purposes of the present review, we singled out the problem concerning the onset and development of this tissue reaction in intervascular anastomoses, which is currently one of the most important issues. Analysing the publications on the problem concerned showed that amongst significantfactors influencing the development of IH in the anastomosis, the investigators single out different parameters of the anastomoses, configuration (either an end-to-end or an end-to-side anastomosis, the use of special inserts and patches within the latter), as well as the use of autologous or synthetic conduits, blanket suture or interrupted suture, peculiarities of local haemodynamics (linear blood flow rate, distribution of parietal fraction forces, zones of stagnation and flow separation), etc. To a certain degree, the published data are rather controversial. There remain many problems, which are either unaddressed as yet, or insufficiently studied, if at all. For instance, while establishing an anastomosis between a bypass graft and an artery, surgeons often resort to endarterectomy. It is not known whether or not this technique would influence the IH pattern in the anastomosis concerned. Neither is it clear whether the high velocity flow exerts a direct damaging action upon the endothelium, whether it promotes the development of IH in the area of the lesion, and if affirmative, then what the mechanisms of this effect really are. Not studied is the role of various types of synthetic fibres and synthetic grafts (except PTFE), various kinds of suture material in the development of IH in the zone of a vascular anastomosis concerned. This of course is far from being a complete list of the challenges requiring further investigation. PMID:19791568

Kur'ianov, P S; Razuvaev, A S; Vavilov, V N

2008-01-01

246

Dihydrotestosterone and the Concept of 5?–Reductase Inhibition in Human Benign Prostatic Hyperplasia  

Microsoft Academic Search

Objective:The development of the human benign prostatic hyperplasia clearly requires a combination of testicular androgens and aging. Although the role of androgens as the causative factor for human benign prostatic hyperplasia is debated, they undoubtedly have at least a permissive role. The principal prostatic androgen is dihydrotestosterone (DHT). Although not elevated in human benign prostatic hyperplasia, DHT levels in the

G. Bartsch; R. S. Rittmaster; H. Klocker

2000-01-01

247

Gene delivery to aortocoronary saphenous vein grafts in a large animal model of intimal hyperplasia  

Microsoft Academic Search

ObjectiveMore than 50% of aortocoronary saphenous vein grafts are occluded 10 years after surgery. Intimal hyperplasia is an initial, critical step in the progression toward occlusion. To date, no clinically relevant large animal models of aortocoronary saphenous vein graft intimal hyperplasia have been fully characterized. Gene therapy holds promise as a novel treatment for aortocoronary saphenous vein graft intimal hyperplasia.

Jason A Petrofski; Jonathan A Hata; Thomas R Gehrig; Steven I Hanish; Matthew L Williams; Richard B Thompson; Cyrus J Parsa; Walter J Koch; Carmelo A Milano

2004-01-01

248

Regenerative implants for cardiovascular tissue engineering.  

PubMed

A fundamental problem that affects the field of cardiovascular surgery is the paucity of autologous tissue available for surgical reconstructive procedures. Although the best results are obtained when an individual's own tissues are used for surgical repair, this is often not possible as a result of pathology of autologous tissues or lack of a compatible replacement source from the body. The use of prosthetics is a popular solution to overcome shortage of autologous tissue, but implantation of these devices comes with an array of additional problems and complications related to biocompatibility. Transplantation offers another option that is widely used but complicated by problems related to rejection and donor organ scarcity. The field of tissue engineering represents a promising new option for replacement surgical procedures. Throughout the years, intensive interdisciplinary, translational research into cardiovascular regenerative implants has been undertaken in an effort to improve surgical outcome and better quality of life for patients with cardiovascular defects. Vascular, valvular, and heart tissue repair are the focus of these efforts. Implants for these neotissues can be divided into 2 groups: biologic and synthetic. These materials are used to facilitate the delivery of cells or drugs to diseased, damaged, or absent tissue. Furthermore, they can function as a tissue-forming device used to enhance the body's own repair mechanisms. Various preclinical studies and clinical trials using these advances have shown that tissue-engineered materials are a viable option for surgical repair, but require refinement if they are going to reach their clinical potential. With the growth and accomplishments this field has already achieved, meeting those goals in the future should be attainable. PMID:24589506

Lee, Avione Y; Mahler, Nathan; Best, Cameron; Lee, Yong-Ung; Breuer, Christopher K

2014-04-01

249

Erich Regener and the ionisation maximum of the atmosphere  

NASA Astrophysics Data System (ADS)

In the 1930s the German physicist Erich Regener (1881-1955) did important work on the measurement of the rate of production of ionisation deep under water and in the atmosphere. Along with one of his students, Georg Pfotzer, he discovered the altitude at which the production of ionisation in the atmosphere reaches a maximum, often, but misleadingly, called the Pfotzer maximum. Regener was one of the first to estimate the energy density of cosmic rays, an estimate that was used by Baade and Zwicky to bolster their postulate that supernovae might be their source. Yet Regener's name is less recognised by present-day cosmic ray physicists than it should be, largely because in 1937 he was forced to take early retirement by the National Socialists as his wife had Jewish ancestors. In this paper we briefly review his work on cosmic rays and recommend an alternative naming of the ionisation maximum. The influence that Regener had on the field through his son, his son-in-law, his grandsons and his students, and through his links with Rutherford's group in Cambridge, is discussed in an appendix. Regener was nominated for the Nobel Prize in Physics by Schrödinger in 1938. He died in 1955 at the age of 73.

Carlson, P.; Watson, A. A.

2014-12-01

250

Rethinking Regenerative Medicine: A Macrophage-Centered Approach  

PubMed Central

Regenerative medicine, a multi-disciplinary approach that seeks to restore form and function to damaged or diseased tissues and organs, has evolved significantly during the past decade. By adapting and integrating fundamental knowledge from cell biology, polymer science, and engineering, coupled with an increasing understanding of the mechanisms which underlie the pathogenesis of specific diseases, regenerative medicine has the potential for innovative and transformative therapies for heretofore unmet medical needs. However, the translation of novel technologies from the benchtop to animal models and clinical settings is non-trivial and requires an understanding of the mechanisms by which the host will respond to these novel therapeutic approaches. The role of the innate immune system, especially the role of macrophages, in the host response to regenerative medicine based strategies has recently received considerable attention. Macrophage phenotype and function have been suggested as critical and determinant factors in downstream outcomes. The constructive and regulatory, and in fact essential, role of macrophages in positive outcomes represents a significant departure from the classical paradigms of host–biomaterial interactions, which typically consider activation of the host immune system as a detrimental event. It appears desirable that emerging regenerative medicine approaches should not only accommodate but also promote the involvement of the immune system to facilitate positive outcomes. Herein, we describe the current understanding of macrophage phenotype as it pertains to regenerative medicine and suggest that improvement of our understanding of context-dependent macrophage polarization will lead to concurrent improvement in outcomes. PMID:25408693

Brown, Bryan N.; Sicari, Brian M.; Badylak, Stephen F.

2014-01-01

251

Not so benign endometrial hyperplasia: Endometrial cancer after endometrial ablation  

Microsoft Academic Search

The masking or development of endometrial cancer after endometrial ablation is a concern often alluded to in discussions of complications of endometrial ablation. It is necessary to look for a common factor when this complication occurs. Six cases published in peer-reviewed literature were collected to establish a link between the development of endometrial cancer and endometrial ablation. Preexisting endometrial hyperplasia

Richard J. Gimpelson

1997-01-01

252

Early Hormonal Influences on Cognitive Functioning in Congenital Adrenal Hyperplasia.  

ERIC Educational Resources Information Center

Reports the results of cognitive test performance and early childhood activities in individuals with congenital adrenal hyperplasia, an autosomal recessive disorder associated with elevated prenatal adrenal androgen levels, demonstrating the effects of early exposure to excess androgenizing hormones on sexually dimorphic cognitive functioning.…

Resnick, Susan M.; And Others

1986-01-01

253

Primary aldosteronism due to unilateral adrenal hyperplasia: a case report.  

PubMed

Primary aldosteronism is one of the differential diagnosis of secondary hypertension. This is usually caused by an aldosterone producing adenoma or bilateral adrenal hyperplasia which comprise about 65% and 30% of the cases, respectively. However, less than 1% of primary aldosteronism is caused by unilateral adrenal hyperplasia which is a relatively rare subset of primary aldosteronism. The clinical and biochemical manifestations of the disorder are indistinguishable from aldosterone-producing tumor, and a definitive diagnosis can only be made by pathological finding. A 33-year-old male Chinese patient presented with hypertension, hypokalemia, metabolic alkalosis, and the hypersecretion of aldosterone associated with suppressed plasma renin activity which is a typical hallmark of primary aldosteronism. Image studies including both magnetic resonance imaging (MRI) and 131I NIP-59 scan as well as postural test suggested an aldosterone-producing tumor of the right adrenal gland. Unilateral adrenectomy and pathological examination of the right adrenal gland eventually proved a case of unilateral adrenal hyperplasia. Blood pressure, plasma potassium, aldosterone and renin activity levels returned to normal two weeks after operation and had remained normal at up to one year of follow up. In addition, a saline loading test showed normal suppression of plasma aldosterone level one year after the operation, suggesting that the function of the left adrenal gland remains normal. The etiology of unilateral adrenal hyperplasia is unclear and the future recurrence of the disease is possible. Long-term follow-up is necessary to ensure the cure of this disorder. PMID:9175301

Chen, L G; Lee, T I; Lin, H D; Wang, H C; Liu, W Y; Tang, K T

1997-02-01

254

Mistaken gender identity in non-classical congenital adrenal hyperplasia  

PubMed Central

Gender identity is the sense of belonging that one feels for a particular sex psychologically and socially, independent of one's biological sex. There is much less systematic data on gender identity in females with congenital adrenal hyperplasia (CAH). We report a case of non-classical CAH presenting as a case of gender identity disorder. PMID:24891708

Kukreti, Prerna; Kandpal, Manish; Jiloha, R. C.

2014-01-01

255

Angiolymphoid hyperplasia with eosinophilia: an unusual presentation in a child.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign proliferation that usually presents as pink to brown dermal nodules in the head and neck region of young adults. We present a biopsy-proven case of ALHE arising in the conjunctiva of an 11-year-old girl. The lesion was treated with excision. After 2 years there has been no recurrence. PMID:18356092

Huang, Margaret; Lloyd, William C; O'Hara, Mary

2008-06-01

256

Angiolymphoid hyperplasia with eosinophilia (alhe): a rare entity for otolaryngologist.  

PubMed

A case of angiolymphoid hyperplasia with eosinophilia (ALHE) is reported. It is a rare and new disease for an otolaryngologist. The difference between the Kimura's disease and ALHE has been discussed. Though it is rare, ALHE should be kept in differential diagnosis for an auricular swelling. PMID:17203832

Ghimire, Anand; Singh, Ishwar; Bhattarai, Manav; Pandey, Sagar Raj

2006-09-01

257

Angiolymphoid hyperplasia with eosinophilia presenting as an axillary artery aneurysm  

PubMed Central

A man in his late 20s presented with a painless swelling in his left axilla accompanied with nocturnal sweating. On examination, there was a well circumscribed, pulsatile lump within the axilla. Subsequent imaging revealed an axillary artery aneurysm with thrombus within. Subsequent surgical repair was undertaken. Subsequent histological examination of the vessel revealed features characteristic of angiolymphoid hyperplasia with eosinophilia. PMID:22696690

Kukreja, Neil; Koslowski, Matthias; Insall, Robert

2011-01-01

258

Angiolymphoid hyperplasia with eosinophilia involving the lacrimal gland: case report.  

PubMed Central

A case is described of a 25-year-old male who developed angiolymphoid hyperplasia with eosinophilia involving the tissue over the left parotid gland and subsequently involving the right lacrimal gland with proptosis. Treatment was by excision. Images PMID:3179260

Cook, H T; Stafford, N D

1988-01-01

259

Angiolymphoid hyperplasia with eosinophilia showing characteristics of Kimura's disease.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign condition affecting principally the head and neck region of young females. We describe a 42-year-old female patient of ALHE showing the typical changes of endothelial cells and features similar to Kimura's disease in histologic and immunohistochemical findings. PMID:10692821

Chung, T S; Kim, D K; Yoon, M S; Yang, W I

2000-01-01

260

Angiolyphoid hyperplasia with eosinophilia occurring after venipuncture trauma.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE), also known as epithelioid hemangioma, is a benign vascular proliferation of uncertain etiology. Herein, we present the first documented case of ALHE following venipuncture and review the published work regarding the relationship of this entity to preceding trauma. PMID:23488565

Stewart, Nicholas; Zagarella, Samuel; Mann, Steve

2013-05-01

261

Association of Benign Prostatic Hyperplasia with Male Pattern Baldness  

Microsoft Academic Search

Objectives. Both benign prostatic hyperplasia (BPH) and male pattern baldness (androgenic alopecia) share the pathogenesis of an androgen-dependent disorder and afflict a large population of elderly men with chronobiologic progress. However, it is unclear whether these diseases are related epidemiologically. We evaluated the association of frequency and severity of male pattern baldness between patients with BPH and a control group.Methods.

Bong Ryoul Oh; Seong Jin Kim; Jai Dong Moon; Hyeung Nam Kim; Dong Duek Kwon; Young Ho Won; Soo Bang Ryu; Yang Il Park

1998-01-01

262

Hyperinsulinaemia as a Risk Factor for Developing Benign Prostatic Hyperplasia  

Microsoft Academic Search

Objective: To determine the validity coefficient of the total prostate gland volume as an expression of the transition zone (TZ) volume. To test the hypothesis of hyperinsulinaemia as a causal factor for the development of benign prostatic hyperplasia (BPH).Patients and Methods: Three hundred and seven consecutive patients with lower urinary tract symptoms were studied. A subgroup of 114 patients were

Jan Hammarsten; Benkt Högstedt

2001-01-01

263

Is Benign Prostatic Hyperplasia (BPH) an Immune Inflammatory Disease?  

Microsoft Academic Search

ObjectivesChronic inflammation has been documented for years in benign prostatic hyperplasia (BPH), but only now has it become evident as a major factor in disease progression. This review highlights the immunologic key features of chronic inflammation in BPH and the present interpretation of these changes in the development and progression of BPH.

Gero Kramer; Dieter Mitteregger; Michael Marberger

2007-01-01

264

Focal fibrous hyperplasia: A review of 193 cases  

PubMed Central

Context: Focal fibrous hyperplasia, also known as irritation or traumatic fibroma, is a reactive, inflammatory hyperplastic lesion of the connective tissue. Aim: The aim of this study is to perform a retrospective study of a focal fibrous hyperplasia of 18 years. Materials and Methods: We retrospectively reviewed 193 cases of focal fibrous hyperplasia of the oral cavity from the medical and histological reports of the Department of Oral Pathology, Pernambuco University, Brazil, during the period between January 1992 and December 2009. Settings and Design: Data with regard to age, gender, location, size of the lesion (equal to or less than 1 cm, between 1 and 2 cm and greater than 2 cm), pain, history of trauma, treatment, length of follow-up (from diagnosis to release or last review) and recurrence, were collected. Results: The most commonly affected site was the buccal mucosa (n = 119, 61.7%). Almost two-thirds of the cases were concentrated from the second to the fifth decade of life. Females were more affected than men and a history of trauma was related by 90.7% of the patients. Two recurrences were notified (1.0%). Conclusion: Further studies are needed on the distribution of the lesion in different ethnic and geographical populations. The influence of sex hormones on the development of focal fibrous hyperplasia must be clarified. PMID:25364187

de Santana Santos, Thiago; Martins-Filho, Paulo Ricardo Saquete; Piva, Marta Rabello; de Souza Andrade, Emanuel Sávio

2014-01-01

265

Psychosexual Development of Women with Congenital Adrenal Hyperplasia  

Microsoft Academic Search

Women with congenital adrenal hyperplasia (CAH) (N= 31) and their unaffected sisters or female cousins (N= 15) participated in a study of psychosexual development. All participants were ?18 years of age (mean age, 25 years; range, 18–40). Comparisons were also made between the CAH women with the salt-wasting (SW) form of the disorder and those with simple virilization (SV). A

Kenneth J. Zucker; Susan J. Bradley; Gillian Oliver; Jennifer Blake; Susan Fleming; Jane Hood

1996-01-01

266

Parathyroid hyperplasia: an unusual cause of neonatal hypercalcemia  

Microsoft Academic Search

Primary hyperparathyroidism (PHPT) in infants is caused by parathyroid chief cell hyperplasia. Patients present with symptoms of chronic hypercalcemia, such as failure to thrive, irritability, abdominal pain, and anorexia. Medical therapy is inadequate, often resulting in chronic hypercalcemia or death. Partial or total surgical removal of the parathyroid gland is the preferred treatment. We describe a case of a 7-month-old

Mary S Payne; Dana L Suskind; Alfonso Vargas; Randall Craver; Donald C Liu

2001-01-01

267

Electric vehicle regenerative antiskid braking and traction control system  

DOEpatents

An antiskid braking and traction control system for an electric or hybrid vehicle having a regenerative braking system operatively connected to an electric traction motor, and a separate hydraulic braking system includes one or more sensors for monitoring present vehicle parameters and a processor, responsive to the sensors, for calculating vehicle parameters defining the vehicle behavior not directly measurable by the sensors and determining if regenerative antiskid braking control, requiring hydraulic braking control, or requiring traction control are required. The processor then employs a control strategy based on the determined vehicle state and provides command signals to a motor controller to control the operation of the electric traction motor and to a brake controller to control fluid pressure applied at each vehicle wheel to provide the appropriate regenerative antiskid braking control, hydraulic braking control, and traction control. 10 figs.

Cikanek, S.R.

1995-09-12

268

Electric vehicle regenerative antiskid braking and traction control system  

DOEpatents

An antiskid braking and traction control system for an electric or hybrid vehicle having a regenerative braking system operatively connected to an electric traction motor, and a separate hydraulic braking system includes one or more sensors for monitoring present vehicle parameters and a processor, responsive to the sensors, for calculating vehicle parameters defining the vehicle behavior not directly measurable by the sensors and determining if regenerative antiskid braking control, requiring hydrualic braking control, or requiring traction control are required. The processor then employs a control strategy based on the determined vehicle state and provides command signals to a motor controller to control the operation of the electric traction motor and to a brake controller to control fluid pressure applied at each vehicle wheel to provide the appropriate regenerative antiskid braking control, hydraulic braking control, and traction control.

Cikanek, Susan R. (Wixom, MI)

1995-01-01

269

25th Anniversary Article: Supramolecular Materials for Regenerative Medicine  

PubMed Central

In supramolecular materials, molecular building blocks are designed to interact with one another via non-covalent interactions in order to create function. This offers the opportunity to create structures similar to those found in living systems that combine order and dynamics through the reversibility of intermolecular bonds. For regenerative medicine there is a great need to develop materials that signal cells effectively, deliver or bind bioactive agents in vivo at controlled rates, have highly tunable mechanical properties, but at the same time, can biodegrade safely and rapidly after fulfilling their function. These requirements make supramolecular materials a great platform to develop regenerative therapies. This review illustrates the emerging science of these materials and their use in a number of applications for regenerative medicine. PMID:24496667

Boekhoven, Job

2014-01-01

270

Regenerative Potential of Endometrial Stem Cells: A Mini Review  

PubMed Central

Recent findings in stem cell biology have opened a new window in regenerative medicine. The endometrium possesses mesenchymal stem cells (MSCs) called endometrial stem cells (EnSCs) having specific regenerative properties linked to adult stem cells. They contribute in tissue remodeling and engineering and were shown to have immuno-modulating effects. Many clinical trials were undertaken to ascertain the therapeutic potential of EnSCS. In this mini review, we showed that EnSCs are readily available sources of adult stem cells in the uterus that can be highlighted for their renewable multipotent and differentiation properties. This cell population may be a practical solution of choice in reproductive biology, regenerative medicine and autologous stem cell therapy. PMID:25606470

Ghobadi, Farnaz; Mehrabani, Davood; Mehrabani, Golnoush

2015-01-01

271

Lightweight pressure vessels and unitized regenerative fuel cells  

SciTech Connect

Energy storage systems have been designed using lightweight pressure vessels with unitized regenerative fuel cells (URFCs). The vessels provide a means of storing reactant gases required for URFCs; they use lightweight bladder liners that act as inflatable mandrels for composite overwrap and provide a permeation barrier. URFC systems have been designed for zero emission vehicles (ZEVs); they are cost competitive with primary FC powered vehicles that operate on H/air with capacitors or batteries for power peaking and regenerative braking. URFCs are capable of regenerative braking via electrolysis and power peaking using low volume/low pressure accumulated oxygen for supercharging the power stack. URFC ZEVs can be safely and rapidly (<5 min.) refueled using home electrolysis units. Reversible operation of cell membrane catalyst is feasible without significant degradation. Such systems would have a rechargeable specific energy > 400 Wh/kg.

Mitlitsky, F.; Myers, B.; Weisberg, A.H.

1996-09-06

272

[Influence of antioxidants on the development of benign prostatic hyperplasia].  

PubMed

The main objectives of the study was the evaluation of concentration of endogenous antioxidants (Vitamins E, A, C and Beta-carotene) in the blood plasma of elderly men and to determine their roles in the development of benign prostatic hyperplasia. There were carried out investigations in 110 men during 2003-2006 in the Urological Clinic of the Tbilisi State Medical Academy. 71 patient entered into the main group (65-81 years old), who were diagnosed for benign prostate hyperplasia. The control group included 30 men (60-80 years old) who did not suffer from the typical signs of benign prostatic hyperplasia. Besides, to evaluate normal levels of endogenous antioxidants (Vitamins E, A, C and Beta-carotene) concentration in the blood plasma additionally were studied young practically healthy 10 persons (20-35 years old), they compiled the second control group. Our study showed that endogenous antioxidants concentration reduces in the blood plasma with the age, this reduction becomes more obvious with the clinical detection of prostate benign hyperplasia. It is recommended for elderly patients to control periodically the endogenous antioxidants level (Vitamins A, C, E and Beta-carotene) in the blood plasma and in the case of changes to get food enriched with vitamins or combined vitamins preparations. This will be accomplice factor for the prophylactic of benign prostatic hyperplasia. This will be prophylactic activity during the conservative treatment process (by alpha-adrenoceptor blocking drugs, phytotherapy medicines, 5 alpha-reductase inhibitors and others). Inclusion of vitamins complexes which contains antioxidants is necessary. Prescription of antioxidants complex after the operative treatment will accelerate the healing process and reduce the rehabilitation period. PMID:17179581

Mchedlidze M G, M G; Shioshvili, T I

2006-11-01

273

Adipocyte-derived stem and regenerative cells in facial rejuvenation.  

PubMed

The identification of regenerative cells in adult human fat has invigorated the field of facial fat grafting. This article reviews traditional and cell-enriched fat grafting methods and the use of fat to create or refine aesthetic results. The rationale and potential applications of adipocyte-derived stem and regenerative cells in facial surgery are also described. The reader is presented with surgical techniques for harvesting and delivering fat grafts to optimize engraftment. Mesotherapy and related applications currently under investigation are also discussed. PMID:23036296

Cohen, Steven R; Mailey, Brian

2012-10-01

274

Ignition feedback regenerative free electron laser (FEL) amplifier  

DOEpatents

An ignition feedback regenerative amplifier consists of an injector, a linear accelerator with energy recovery, and a high-gain free electron laser amplifier. A fraction of the free electron laser output is coupled to the input to operate the free electron laser in the regenerative mode. A mode filter in this loop prevents run away instability. Another fraction of the output, after suitable frequency up conversion, is used to drive the photocathode. An external laser is provided to start up both the amplifier and the injector, thus igniting the system.

Kim, Kwang-Je (Burr Ridge, IL); Zholents, Alexander (Walnut Creek, CA); Zolotorev, Max (Oakland, CA)

2001-01-01

275

A high-power compact regenerative amplifier FEL  

SciTech Connect

The Regenerative Amplifier FEL (RAFEL) is a new FEL approach aimed at achieving the highest optical power from a compact rf-linac FEL. The key idea is to feed back a small fraction (< 10%) of the optical power into a high-gain ({approximately}10{sup 5} in single pass) wiggler to enable the FEL to reach saturation in a few passes. This paper summarizes the design of a high-power compact regenerative amplifier FEL and describes the first experimental demonstration of the RAFEL concept.

Nguyen, D.C.; Sheffield, R.L.; Fortgang, C.M.; Kinross-Wright, J.M.; Ebrahim, N.A.; Goldstein, J.C.

1997-08-01

276

Thin-rod Yb:YAG regenerative laser amplifier  

NASA Astrophysics Data System (ADS)

High-average-power, high-repetition-rates picosecond-pulsed regenerative ytterbium-doped yttrium aluminum garnet (Yb:YAG) laser amplifiers were developed. The architecture used in the amplifiers, which are named as thin-rod, has a unique cooling scheme like slab lasers and also has a unique pumping scheme like photonic crystal fiber lasers, is suitable for high-average power Ytterbium lasers. This architecture also has high gain characteristics which is appropriate for the regenerative spectral and pulse shaping on high-repetition-rate, ultrashort-pulse amplifications.

Maruko, A.; Nishio, M.; Matsubara, S.; Tanaka, M.; Takama, M.; Yoshida, T.; Kyomoto, K.; Okunishi, H.; Kato, K.; Shimabayashi, K.; Morioka, M.; Inayoshi, S.; Yamagata, S.; Kawato, S.

2014-09-01

277

Validation of Contrast-Enhanced MRI to Monitor Regenerative Efficacy after Cell Therapy in a Porcine Model of Convalescent Myocardial Infarction  

PubMed Central

Background Magnetic Resonance Imaging (MRI) in the CADUCEUS trial revealed that cardiosphere-derived cells (CDCs) decrease scar size and increase viable myocardium post-myocardial infarction (MI), but MRI has not been validated as an index of regeneration after cell therapy. We tested the validity of contrast-enhanced MRI in quantifying scarred and viable myocardium after cell therapy in a porcine model of convalescent MI. Methods and Results Yucatan minipigs underwent induction of MI and 2-3 weeks later were randomized to receive intracoronary infusion of 12.5×106 mismatched allogeneic CDCs or vehicle. Allogeneic CDCs induced mild local mononuclear infiltration but no systemic immunogenicity. MRI revealed that allogeneic CDCs attenuated remodeling, improved global and regional function, decreased scar size and increased viable myocardium compared to placebo 2 months post-treatment. Extensive histological analysis validated quantitatively the MRI measurements of scar size, scar mass and viable mass. CDCs neither altered gadolinium contrast myocardial kinetics, nor induced changes in vascular density or architecture in viable and scarred myocardium. Histology demonstrated that CDCs lead to cardiomyocyte hyperplasia in the border zone, consistent with the observed stimulation of endogenous regenerative mechanisms (cardiomyocyte cycling, upregulation of endogenous progenitors, angiogenesis). Conclusions Contrast-enhanced MRI accurately measures scarred and viable myocardium after cell therapy in a porcine model of convalescent MI. MRI represents a useful tool for assessing dynamic changes in the infarct and monitoring regenerative efficacy. PMID:24061088

Malliaras, Konstantinos; Smith, Rachel R.; Kanazawa, Hideaki; Yee, Kristine; Seinfeld, Jeffrey; Tseliou, Eleni; Dawkins, James F.; Kreke, Michelle; Cheng, Ke; Luthringer, Daniel; Ho, Chak-Sum; Blusztajn, Agnieszka; Valle, Ileana; Chowdhury, Supurna; Makkar, Raj R.; Dharmakumar, Rohan; Li, Debiao; Marbán, Linda; Marbán, Eduardo

2014-01-01

278

SPE (tm) regenerative hydrogen/oxygen fuel cells for extraterrestrial surface and microgravity applications  

NASA Technical Reports Server (NTRS)

Viewgraphs on SPE regenerative hydrogen/oxygen fuel cells for extraterrestrial surface and microgravity applications are presented. Topics covered include: hydrogen-oxygen regenerative fuel cell energy storage system; electrochemical cell reactions; SPE cell voltage stability; passive water removal SPE fuel cell; fuel cell performance; SPE water electrolyzers; hydrophobic oxygen phase separator; hydrophilic/electrochemical hydrogen phase separator; and unitized regenerative fuel cell.

Mcelroy, J. F.

1990-01-01

279

Name: dhr. prof. dr. W.J.A Dhert Regenerative Medicine  

E-print Network

Name: dhr. prof. dr. W.J.A Dhert Profile Teaching commitment Regenerative Medicine Faculty Medicine Congress 2008 · Vice chair Dutch Forum Regenerative Medicine · Board member Dutch Program for Tissue of the Smart Mix TeRM `Translational Regenerative Medicine' Program Curriculum vitae · Associate professor

Utrecht, Universiteit

280

Structural characterization of [(?-H)Os 3(CO) 10(?-NH 2)] and a new polymorphic form of [(?-H)Os 3(CO) 10(?-SH)]. Influence of the bridging group on the geometry of compounds [(?-H)Os 3(CO) 10(?-X)] (X = NH 2, NRH, PRH, SbR 2, OH, SH, SR, SeR, Cl, Br). Reactions of [(?-H)Os 3(CO) 10(?-X)] (X = OH and SH) with proton sponge  

NASA Astrophysics Data System (ADS)

Compounds [(?-H)Os 3(CO) 10(?-NH 2)] and a new polymorphic form of [(?-H)Os 3(CO) 10(?-SH)] were obtained from the reaction of [H 2Os 3(CO) 10] with 1,3,5-N,N,N,-trimethyl-triazinane and 1,3,5-trithiane respectively. The structures show the same geometry described for other doubly bridged triangular clusters. A comparison of these type of compounds show that the bridging group does not affect significantly the dihedral angle between Os 3 and Os 2X planes (X = NH 2, NRH, PRH, SbR 2, OH, OR, SH, SR, SeR, Cl and Br). The presence of a hydrogen atom on the bridge could favor a possible interaction between groups so the crystal packing is analyzed. Since intermolecular interactions could also be occurring in solution, reactions of [(?-H)Os 3(CO) 10(?-OH)] and [(?-H)Os 3(CO) 10(?-SH)] with proton sponge were carried out in order to determine if the OH or SH protons had acidic character and could react with a base. These results and other structural characteristics will be discussed.

Reyes-López, Ottmar R.; Leyva, Marco A.; Rosales-Hoz, María J.

2011-01-01

281

A NITROSYL CHLORIDE SOLAR REGENERATIVE FUEL CELL SYSTEM  

Microsoft Academic Search

The experimenial work accomplished during the period of October 1960 to ; April 1961 in the development of the nitrosyl chloride solar regenerative fuel ; cell system is described. Regeneration is accomplished utilizing solar energy to ; dissociate nitrosyl chloride into nitric oxide and chlorine. Product separation ; is accomplished using solvent extraction techniques. The separated dissociation ; products are

W. E. McKee; E. Findl; J. D. Margerum; W. B. Lee

1961-01-01

282

REGENERATIVE MEDICINE Tracking Stem Cell Differentiation in the Setting  

E-print Network

Key Words. Embryonic stem cells · Optogenetics · Channelrhodopsin-2 · Neuronal differentiation of stem cells and in the survival and function of mature neurons. Here, we introduce a microbial opsinREGENERATIVE MEDICINE Tracking Stem Cell Differentiation in the Setting of Automated Optogenetic

Schnitzer, Mark

283

Status of the Regenerative ECLS Water Recovery System  

NASA Technical Reports Server (NTRS)

The regenerative Water Recovery System (WRS) has completed its first full year of operation on the International Space Station (ISS). The major assemblies included in this system are the Water Processor Assembly (WPA) and Urine Processor Assembly (UPA). This paper summarizes the on-orbit status as of May 2010, and describes the technical challenges encountered and lessons learned over the past year.

Carter, Donald Layne

2010-01-01

284

Erich Regener and the maximum in ionisation of the atmosphere  

E-print Network

In the 1930s the German physicist Erich Regener (1881-1955) did important work on the measurement of the rate of production of ionisation deep under-water and in the atmosphere. He discovered, along with one of his students, Georg Pfotzer, the altitude at which the production of ionisation in the atmosphere reaches a maximum, often, but misleadingly, called the Pfotzer maximum. Regener was one of the first to estimate the energy density of cosmic rays, an estimate that was used by Baade and Zwicky to bolster their postulate that supernovae might be their source. Yet Regener's name is less recognised by present-day cosmic ray physicists than it should be largely because in 1937 he was forced to take early retirement by the National Socialists as his wife had Jewish ancestors. In this paper we briefly review his work on cosmic rays and recommend an alternative naming of the ionisation maximum. The influence that Regener had on the field through his son, his son-in-law, his grandsons and his students and through...

Carlson, P

2014-01-01

285

Feasibility Study of Regenerative Burners in Aluminum Holding Furnaces  

NASA Astrophysics Data System (ADS)

Gas-fired aluminum holding reverberatory furnaces are currently considered to be the lowest efficiency fossil fuel system. A considerable volume of gas is consumed to hold the molten metal at temperature that is much lower than the flame temperature. This will lead to more effort and energy consumption to capture the excessive production of the CO2. The concern of this study is to investigate the feasibility of the regenerative-burners' furnaces to increase the furnace efficiency to reduce gas consumption per production and hence result in less CO2 production. Energy assessments for metal holding furnaces are considered at different operation conditions. Onsite measurements, supervisory control and data acquisition data, and thermodynamics analysis are performed to provide feasible information about the gas consumption and CO2 production as well as area of improvements. In this study, onsite measurements are used with thermodynamics modeling to assess a 130 MT rectangular furnace with two regenerative burners and one cold-air holding burner. The assessment showed that the regenerative burner furnaces are not profitable in saving energy, in addition to the negative impact on the furnace life. However, reducing the holding and door opening time would significantly increase the operation efficiency and hence gain the benefit of the regenerative technology.

Hassan, Mohamed I.; Al Kindi, Rashid

2014-09-01

286

Active regenerative chatter suppression during boring manufacturing process  

Microsoft Academic Search

Machining performance such as that of the boring process is often limited by chatter vibration at the tool–workpiece interface. Among various sources of chatter, regenerative chatter in cutting systems is found to be the most detrimental. It limits cutting depth (as a result, productivity), adversely affects surface finish and causes premature tool failure. Though the machining system is a distributed

C. Mei

2005-01-01

287

A new perspective and analysis for regenerative machine tool chatter  

Microsoft Academic Search

The paper contains a practical perspective on regenerative machine tool chatter. Chatter is a well known phenomenon, occurrence of which is undesired in manufacturing. Aggressive machining conditions, in the sense of removing more metal rapidly, usually cause chatter. In most cases, these conditions can be determined a priori to the operation. A chatter stability study and its reasoning based on

Nejat Olgac; Martin Hosek

1998-01-01

288

Regenerative cooling for liquid propellant rocket thrust chambers  

Microsoft Academic Search

This work describes a calculation model for regeneratively cooled rocket thrust chambers. A computational program, based on a one-dimensional coolant pressure drop in the cooling channels. Radiation is included in the model. The channels have rectangular cross sections, the dimensions being determined during the calculations in order to maintain the wall temperature distributions at tolerable levels, with a minimum channel

Rafael Levy Rubin

1994-01-01

289

Frequency-Domain Analysis of Super-Regenerative Amplifiers  

E-print Network

Since its invention in 1922, the super-regenerative amplifier (SRA) has been used in a variety of short-range, low-power, and/or low-cost wireless systems due to its simple implementation and excellent performance for a ...

Dawson, Joel L.

290

Stem Cells, Regenerative Medicine, and Animal Models of Disease  

Microsoft Academic Search

The field of stem cell biology and regenerative medicine is rapidly moving toward translation to clinical practice, and in doing so has become even more dependent on animal donors and hosts for generating cellular reagents and assay- ing their potential therapeutic efficacy in models of human disease. Advances in cell culture technologies have revealed a remarkable plasticity of stem cells

Dennis A. Steindler

2007-01-01

291

Potential of Human Embryonic Stem Cells in Regenerative Medicine  

Microsoft Academic Search

Stem cells can give rise to more stem cells or differentiate into more specialized cells. In the last 5 years not only have researchers succeeded in isolating human embryonic stem (hES) cell lines but also in identifying adult stem cells with possible pluripotent differentiation capacity. The shortage of donor organs or tissues for regenerative medicine has further stimulated research into

Robert Passier

2003-01-01

292

Fingertip Vibratory Transducer for Detecting Optical Edges Using Regenerative Feedback  

E-print Network

. The laser vibrates across a properly oriented optical edge. #12;2 METHODS The SPLOT system worksFingertip Vibratory Transducer for Detecting Optical Edges Using Regenerative Feedback Kimberly, which converts properly oriented edges into tactile vibration. The system may allow visually impaired

Stetten, George

293

Modeling and Simulation about an Electric Car's Regenerative Braking System  

Microsoft Academic Search

A kind of regenerative braking system of an electric car is studied in the paper. The car's speed, acceleration, the hydraulic accumulator's pressure and volume are simulated with Matlab while the electric car is braking or accelerating from stop. The hydraulic accumulator can absorb all of the braking energy when braking and the energy stored in the hydraulic accumulator can

Zuowu Ding; Dongbiao Zhao; Jianmin Zuo

2007-01-01

294

Regenerative memory in time-delayed neuromorphic photonic systems  

E-print Network

We investigate a regenerative memory based upon a time-delayed neuromorphic photonic oscillator and discuss the link with temporal localized structures. Our experimental implementation is based upon a optoelectronic system composed of a nanoscale nonlinear resonant tunneling diode coupled to a laser that we link to the paradigm of neuronal activity, the FitzHugh-Nagumo model with delayed feedback.

Romeira, B; Figueiredo, José M L; Barland, S; Javaloyes, J

2015-01-01

295

Permanent magnet synchronous generators for regenerative energy conversion - a survey  

Microsoft Academic Search

A survey on recently installed or developed permanent magnet (PM) synchronous generators for energy conversion in regenerative and alternative power supply systems is given. Its focus is for low speed machines on geared and gearless PM generator systems for wind power plants and small PM hydro generators in gearless coupling. For distributed co-generation of heat and electrical power by micro

Andreas Binder; Tobias Schneider

2005-01-01

296

A Regeneratively Cooled Thrust Chamber For The Fastrac Engine  

NASA Technical Reports Server (NTRS)

Abstract This paper presents the development of a low-cost, regeneratively-cooled thrust chamber for the Fastrac engine. The chamber was fabricated using hydraformed copper tubing to form the coolant jacket and wrapped with a fiber reinforced polymer composite Material to form a structural jacket. The thrust chamber design and fabrication approach was based upon Space America. Inc.'s 12,000 lb regeneratively-cooled LOX/kerosene rocket engine. Fabrication of regeneratively cooled thrust chambers by tubewall construction dates back to the early US ballistic missile programs. The most significant innovations in this design was the development of a low-cost process for fabrication from copper tubing (nickel alloy was the usual practice) and use of graphite composite overwrap as the pressure containment, which yields an easily fabricated, lightweight pressure jacket around the copper tubes A regeneratively-cooled reusable thrust chamber can benefit the Fastrac engine program by allowing more efficient (cost and scheduler testing). A proof-of-concept test article has been fabricated and will he tested at Marshall Space Flight Center in the late Summer or Fall of 2000.

Brown, Kendall K.; Sparks, Dave; Woodcock, Gordon

2000-01-01

297

California Institute for Regenerative Medicine (CIRM) Stem Cell Basics Videos  

NSDL National Science Digital Library

This collection of videos, from the California Institute for Regenerative Medicine, features researchers as they "explain the basics of stem cell research and discuss the many hurdles in translating the basic research into new therapies." Some of the topics covered here include: creating embryonic stem cell lines, therapies based on cancer stem cells, therapy development, stem cell differentiation, ethics, and more.

298

Regenerative Snubber For GTO-Commutated SCR Inverter  

NASA Technical Reports Server (NTRS)

Proposed regenerative snubbing circuit substituted for dissipative snubbing circuit in inverter based on silicon controlled rectifiers (SCR's) commutated by gate-turn-off thyristor (GTO). Intended to reduce loss of power that occurs in dissipative snubber. Principal criteria in design: low cost, simplicity, and reliability.

Rippel, Wally E.; Edwards, Dean B.

1992-01-01

299

Adipose-Derived Stem Cells for Regenerative Medicine  

Microsoft Academic Search

Abstract—The emerging field of regenerative medicine will require a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue represents an abundant and accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in

Gary Lopaschuk; Jeffrey M. Gimble; Adam J. Katz; Bruce A. Bunnell

2010-01-01

300

Mesenchymal stem cells for tissue engineering and regenerative medicine  

Microsoft Academic Search

Mesenchymal stem cells (MSCs) exist in bone marrow and other musculoskeletal tissues. These cells contribute to the homeostasis of musculoskeletal tissue as well as support for the growth and differentiation of primitive hemopoietic cells. Recent advancements in tissue engineering and regenerative medicine have highlighted MSCs as a potential source of cells which would differentiate to a variety of tissue tailored

Suk-Kee Tae; Seok-Hyn Lee; Jae-Sik Park; Gun-Il Im

2006-01-01

301

Cell delivery in regenerative medicine: The cell sheet engineering approach  

Microsoft Academic Search

Recently, cell-based therapies have developed as a foundation for regenerative medicine. General approaches for cell delivery have thus far involved the use of direct injection of single cell suspensions into the target tissues. Additionally, tissue engineering with the general paradigm of seeding cells into biodegradable scaffolds has also evolved as a method for the reconstruction of various tissues and organs.

Joseph Yang; Masayuki Yamato; Kohji Nishida; Takeshi Ohki; Masato Kanzaki; Hidekazu Sekine; Tatsuya Shimizu; Teruo Okano

2006-01-01

302

Regenerative medicine and human models of human disease  

Microsoft Academic Search

Recent advances in stem-cell technology are now allowing the mechanisms of human disease to be studied in human cells. A new era for regenerative medicine is arising from such disease models, extending beyond early cell-based therapies and towards evaluating genetic variation in humans and identifying the molecular pathways that lead to disease, as well as targets for therapy.

Kenneth R. Chien

2008-01-01

303

Smart biomaterials design for tissue engineering and regenerative medicine  

Microsoft Academic Search

As a prominent tool in regenerative medicine, tissue engineering (TE) has been an active field of scientific research for nearly three decades. Clinical application of TE technologies has been relatively restricted, however, owing in part to the limited number of biomaterials that are approved for human use. While many excellent biomaterials have been developed in recent years, their translation into

Mark E. Furth; Anthony Atala; Mark E. Van Dyke

2007-01-01

304

Induced pluripotent stem cells: developmental biology to regenerative medicine  

Microsoft Academic Search

Nuclear reprogramming of somatic cells with ectopic stemness factors to bioengineer pluripotent autologous stem cells signals a new era in regenerative medicine. The study of developmental biology has provided a roadmap for cardiac differentiation from embryonic tissue formation to adult heart muscle rejuvenation. Understanding the molecular mechanisms of stem-cell-derived cardiogenesis enables the reproducible generation, isolation, and monitoring of progenitors that

Almudena Martinez-Fernandez; Andre Terzic; Timothy J. Nelson

2010-01-01

305

Strategies for Improving Animal Models for Regenerative Medicine  

PubMed Central

The field of regenerative medicine is moving toward translation to clinical practice. However, there are still knowledge gaps and safety concerns regarding stem cell-based therapies. Improving large animal models and methods for transplantation, engraftment, and imaging should help address these issues, facilitating eventual use of stem cells in the clinic. PMID:23472868

Cibelli, Jose; Emborg, Marina E.; Prockop, Darwin J.; Roberts, Michael; Schatten, Gerald; Rao, Mahendra; Harding, John; Mirochnitchenko, Oleg

2015-01-01

306

Pictures of focal nodular hyperplasia and hepatocellular adenomas  

PubMed Central

This practical atlas aims to help liver and non liver pathologists to recognize benign hepatocellular nodules on resected specimen. Macroscopic and microscopic views together with immunohistochemical stains illustrate typical and atypical aspects of focal nodular hyperplasia and of hepatocellular adenoma, including hepatocellular adenomas subtypes with references to clinical and imaging data. Each step is important to make a correct diagnosis. The specimen including the nodule and the non-tumoral liver should be sliced, photographed and all different looking areas adequately sampled for paraffin inclusion. Routine histology includes HE, trichrome and cytokeratin 7. Immunohistochemistry includes glutamine synthase and according to the above results additional markers such as liver fatty acid binding protein, C reactive protein and beta catenin may be realized to differentiate focal nodular hyperplasia from hepatocellular adenoma subtypes. Clues for differential diagnosis and pitfalls are explained and illustrated. PMID:25232451

Sempoux, Christine; Balabaud, Charles; Bioulac-Sage, Paulette

2014-01-01

307

Prenatal treatment of congenital adrenal hyperplasia: risks outweigh benefits.  

PubMed

Prenatal treatment of congenital adrenal hyperplasia by administering dexamethasone to a woman presumed to be carrying an at-risk fetus has been described as safe and effective in several reports. A review of data from animal experimentation and human trials indicates that first-trimester dexamethasone decreases birthweight; affects renal, pancreatic beta cell, and brain development; increases anxiety; and predisposes to adult hypertension and hyperglycemia. In human studies, first-trimester dexamethasone is associated with orofacial clefts, decreased birthweight, poorer verbal working memory, and poorer self-perception of scholastic and social competence. Numerous medical societies have cautioned that prenatal treatment of congenital adrenal hyperplasia with dexamethasone should only be done in prospective clinical research settings with institutional review board approval, and therefore is not appropriate for routine community practice. PMID:23123167

Miller, Walter L; Witchel, Selma Feldman

2013-05-01

308

Clinical outcomes of childhood x-irradiation for lymphoid hyperplasia  

SciTech Connect

A prospective study was conducted to explore the relationship between childhood x-irradiation for lymphoid hyperplasia and the subsequent development of thyroid gland and other head and neck disorders. All individuals under 18 years of age who were x-irradiated for lymphoid hyperplasia during the years 1938-69 at Children's Hospital Medical Center, Boston comprised the exposed population. The comparison group consisted of non-exposed, surgically treated individuals. The study included a health questionnaire and a clinical examination component. A history of thyroid cancer was reported by 11 exposed subjects and no non-exposed subjects. Significantly elevated standardized incidence ratios of thyroid cancer were seen for both exposed males and females, 19.9 and 12.1, respectively. The average thyroid radiation dose was 25.8 rads and the mean latency period was 17.3 years.

Pottern, L.M.

1987-01-01

309

Mesenchymal stem cell secretome and regenerative therapy after cancer.  

PubMed

Cancer treatment generally relies on tumor ablative techniques that can lead to major functional or disfiguring defects. These post-therapy impairments require the development of safe regenerative therapy strategies during cancer remission. Many current tissue repair approaches exploit paracrine (immunomodulatory, pro-angiogenic, anti-apoptotic and pro-survival effects) or restoring (functional or structural tissue repair) properties of mesenchymal stem/stromal cells (MSC). Yet, a major concern in the application of regenerative therapies during cancer remission remains the possible triggering of cancer recurrence. Tumor relapse implies the persistence of rare subsets of tumor-initiating cancer cells which can escape anti-cancer therapies and lie dormant in specific niches awaiting reactivation via unknown stimuli. Many of the components required for successful regenerative therapy (revascularization, immunosuppression, cellular homing, tissue growth promotion) are also critical for tumor progression and metastasis. While bi-directional crosstalk between tumorigenic cells (especially aggressive cancer cell lines) and MSC (including tumor stroma-resident populations) has been demonstrated in a variety of cancers, the effects of local or systemic MSC delivery for regenerative purposes on persisting cancer cells during remission remain controversial. Both pro- and anti-tumorigenic effects of MSC have been reported in the literature. Our own data using breast cancer clinical isolates have suggested that dormant-like tumor-initiating cells do not respond to MSC signals, unlike actively dividing cancer cells which benefited from the presence of supportive MSC. The secretome of MSC isolated from various tissues may partially diverge, but it includes a core of cytokines (i.e. CCL2, CCL5, IL-6, TGF?, VEGF), which have been implicated in tumor growth and/or metastasis. This article reviews published models for studying interactions between MSC and cancer cells with a focus on the impact of MSC secretome on cancer cell activity, and discusses the implications for regenerative therapy after cancer. PMID:23747841

Zimmerlin, Ludovic; Park, Tea Soon; Zambidis, Elias T; Donnenberg, Vera S; Donnenberg, Albert D

2013-12-01

310

Regenerative Wound Healing: The Role of Interleukin-10  

PubMed Central

Significance: Postnatal wounds heal with characteristic scar formation. In contrast, the mid-gestational fetus is capable of regenerative healing, which results in wound repair that is indistinguishable from uninjured skin. However, the underlying mechanisms of fetal regenerative phenotype are unknown. Recent Advances: The potent anti-inflammatory cytokine, interleukin-10 (IL-10), plays an essential role in the ability of the fetus to heal regeneratively and has been shown to recapitulate scarless healing in postnatal tissue. IL-10's ability to facilitate regenerative healing is likely a result of pleiotropic effects, through regulation of the inflammatory response, as well as novel roles as a regulator of the extracellular matrix, fibroblast cellular function, and endothelial progenitor cells. Overexpression of IL-10 using a variety of methods has been demonstrated to recapitulate the fetal regenerative phenotype in post-natal tissue, in conjunction with promising results of Phase II clinical trials using recombinant IL-10. Critical Issues: Successful wound healing is a complex process that requires coordination of multiple growth factors, cell types, and extracellular cellular matrix components. IL-10 has been demonstrated to be critical in the fetus' intrinsic ability to heal without scars, and, further, can induce scarless healing in postnatal tissue. The mechanisms through which IL-10 facilitates this regeneration are likely the result of IL-10's pleiotropic effects. Efforts to develop IL-10 as an anti-scarring agent have demonstrated promising results. Future Directions: Further studies on the delivery, including dose, route, and timing, are required in order to successfully translate these promising findings from in vitro studies and animal models into clinical practice. IL-10 holds significant potential as an anti-scarring therapeutic. PMID:24757588

King, Alice; Balaji, Swathi; Le, Louis D.; Crombleholme, Timothy M.; Keswani, Sundeep G.

2014-01-01

311

Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages  

PubMed Central

Background Xenopus laevis has regenerative and non-regenerative stages. As a tadpole, it is fully capable of functional recovery after a spinal cord injury, while its juvenile form (froglet) loses this capability during metamorphosis. We envision that comparative studies between regenerative and non-regenerative stages in Xenopus could aid in understanding why spinal cord regeneration fails in human beings. Results To identify the mechanisms that allow the tadpole to regenerate and inhibit regeneration in the froglet, we obtained a transcriptome-wide profile of the response to spinal cord injury in Xenopus regenerative and non-regenerative stages. We found extensive transcriptome changes in regenerative tadpoles at 1 day after injury, while this was only observed by 6 days after injury in non-regenerative froglets. In addition, when comparing both stages, we found that they deployed a very different repertoire of transcripts, with more than 80% of them regulated in only one stage, including previously unannotated transcripts. This was supported by gene ontology enrichment analysis and validated by RT-qPCR, which showed that transcripts involved in metabolism, response to stress, cell cycle, development, immune response and inflammation, neurogenesis, and axonal regeneration were regulated differentially between regenerative and non-regenerative stages. Conclusions We identified differences in the timing of the transcriptional response and in the inventory of regulated transcripts and biological processes activated in response to spinal cord injury when comparing regenerative and non-regenerative stages. These genes and biological processes provide an entry point to understand why regeneration fails in mammals. Furthermore, our results introduce Xenopus laevis as a genetic model organism to study spinal cord regeneration. PMID:24885550

2014-01-01

312

Angiolymphoid hyperplasia with eosinophilia of the parapharyngeal space.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign condition characterized by cutaneous nodules with a predeliction for the head and neck region. Extracutaneous involvement is rare. We report a 44-year-old woman who had a large submucosal ALHE tumour in the parapharyngeal space. Our patient is of interest because of the unusual, and as far as we are aware from the literature, unique site and presentation of her lesion. PMID:9850333

Backhouse, S S; Shone, G R; Douglas-Jones, A G

1998-08-01

313

Profound proliferating angiolymphoid hyperplasia with eosinophilia of pregnancy mimicking angiosarcoma.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign vascular proliferation that clinically manifests as nodules and papules of the head and neck region. We report a profound, rapidly proliferating case of ALHE in a 3-week postpartum woman that clinically mimicked angiosarcoma. The clinical and histologic features of ALHE, Kitamura disease, and cutaneous angiosarcoma are reviewed, and the relationship between ALHE and pregnancy is discussed. PMID:22017064

Marcum, Catherine B; Zager, Jonathan S; Bélongie, Iriana P; Messina, Jane L; Fenske, Neil Alan

2011-09-01

314

Epithelioid Hemangioma (Angiolymphoid Hyperplasia with Eosinophilia) in Zosteriform Distribution  

PubMed Central

Epithelioid hemangioma (EH) or angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign disease. We report an unusual case of EH (ALHE) that arose on the lower back in a zosteriform array. The presence of the characteristic histological appearance of plump endothelial cells with hobnail-like protrusions led to the diagnosis of EH (ALHE). Histological examination of the lesion also revealed the existence of arteriovenous shunts, the possible factor contributing to the pathogenesis of EH (ALHE). PMID:23112366

Kurihara, Yuichi; Inoue, Hiroyoshi; Kiryu, Hiromaro; Furue, Masutaka

2012-01-01

315

Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) in zosteriform distribution.  

PubMed

Epithelioid hemangioma (EH) or angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign disease. We report an unusual case of EH (ALHE) that arose on the lower back in a zosteriform array. The presence of the characteristic histological appearance of plump endothelial cells with hobnail-like protrusions led to the diagnosis of EH (ALHE). Histological examination of the lesion also revealed the existence of arteriovenous shunts, the possible factor contributing to the pathogenesis of EH (ALHE). PMID:23112366

Kurihara, Yuichi; Inoue, Hiroyoshi; Kiryu, Hiromaro; Furue, Masutaka

2012-09-01

316

Overview of interventional treatment options for benign prostatic hyperplasia  

PubMed Central

Transurethral resection of the prostate (TURP) remains the gold standard surgical intervention for men with benign prostatic hyperplasia (BPH). However, there are other, newer technologies that have also demonstrated safety and efficacy at least equivalent to that of TURP (e.g., Holmium laser, photoselective vaporization of the prostate). These minimally invasive techniques may be particularly useful for selected patient populations (e.g., those on anticoagulant therapy). PMID:23092781

Elhilali, Mostafa M.

2012-01-01

317

Supernumerary nostril: Congenital adrenal hyperplasia with a rare congenital anomaly  

PubMed Central

Multiple or supernumerary nostril is a rare congenital anomaly with unknown etiology. The first case was reported by Lindsay as bilateral supernumerary nostrils. Supernumerary nostril cases are mostly unilateral and isolated. They are also reported with other congenital malformations like facial clefts and congenital anomalies like congenital auricular hypoplasia, congenital cataracts, eusophageal atresia and patent ductus arteriosus. Here, we report a case of supernumerary nostril with congenital adrenal hyperplasia PMID:25593872

Ciloglu, Sinem; Duran, Alpay; Buyukdogan, Hasan; Yigit, Ahmet K.

2014-01-01

318

Conservative non-instrumental treatment of benign prostatic hyperplasia  

Microsoft Academic Search

This paper critically reviews the clinical effects in benign prostatic hyperplasia (BPH) patients that can be achieved with the presently available medical treatment options. The classes of drugs that are reviewed include: 5-a-reductase inhibitors,a-blockers, cholesterol-lowering agents and phytotherapeutic drugs. Only double-blind placebo-controlled studies with a duration of at least 3 months that have reported symptomatic changes and changes in flow

J. L. H. Ruud Bosch

1997-01-01

319

[High condylectomy for control of pathological growth in condylar hyperplasia].  

PubMed

With the aim of eliminating pathological growth during the active period of condylar hyperplasia, 17 patients were treated with a high condylectomy with a retroauricular incision. Postoperatively none of the patients showed signs of continuing growth activity neither clinically nor roentgenologically. Thus, the high condylectomy can be recommended as a reliable technique to stop pathological and untimely growth with a low risk of complications, before occlusion and skeletal asymmetry are corrected by orthodontic surgery. PMID:9424366

Appel, T; Niederhagen, B; Braumann, B; Reich, R H

1997-05-01

320

Therapeutic options in the treatment of benign prostatic hyperplasia  

PubMed Central

Current theraputic options for the treatment of symptomatic benign prostatic hyperplasia (BPH) are reviewed. Therapeutic options for mild lower urinary tract symptoms (LUTS), as defined by the American Urological Association, are generally treated medically. Moderate to severe LUTS can be treated medically or with surgical therapy. Current medical and surgical treatments for LUTS secondary to BPH are reviewed and evolving treatments are explored. PMID:19936164

Sandhu, Jaspreet S

2009-01-01

321

Vaginal hyperplasia in the bitch: Literature review and commentary  

PubMed Central

We reviewed the incidence, etiology, clinical presentations, diagnosis, treatments and prevention of canine vaginal hyperplasia, and describe a simple surgical technique for its correction as practiced at the Small Animal Clinic, State University of Utrecht, The Netherlands. Many different treatments have been used, and some are novel approaches. In many cases, prevention is accomplished if the bitch is ovariectomized; there is a high incidence of recurrence with medical treatment. PMID:17423719

Post, Klaas; Van Haaften, Bas; Okkens, Auke C.

1991-01-01

322

Hot spot liver scan in focal nodular hyperplasia  

SciTech Connect

In scintigraphy of the liver with radiocolloid, space-occupying lesions generally are visualized as regions of decreased accumulation of radioactivity. Rarely focal areas of increased activity are depicted; most are related to altered vascular dynamics in the liver secondary to obstruction of the superior or inferior vena cava or the hepatic veins. There are reports of single cases of focally increased activity due to a hepatic hemangioma, hepatic venoocclusive disease, herniation of a part of the liver, and a liver hot spot found after radiocolloid injection via a malpositioned central venous catheter in one of the hepatic vein branches. In patients with focal nodular hyperplasia, liver scans with solitary defects as well as normal patterns are found. In some cases, increased uptake of colloid in the lesion has been documented. Pasquier and Dorta reported a patient with a palpable mass in the left liver lobe with increased accumulation of radioactivity on the radiocolloid liver scan. The histologic diagnosis was hamartoma, but reviewing the description and considering the confusion in the past concerning the nomenclature, this case is suggestive of focal nodular hyperplasia. We report a patient with focal nodular hyperplasia who had increased radiocolloid uptake in the lesion. The radionuclide studies are compared with angiography, sonography, and computed tomography. An explanation for the localized increased colloid accumulation based on histologic findings is suggested.

Piers, D.A. (Univ. Hospital, Groningen, Netherlands); Houthoff, H.J.; Krom, R.A.F.; Schuur, K.H.; Sikkens, H.; Weits, J.

1980-12-01

323

Social dominance in tilapia is associated with gonadotroph hyperplasia.  

PubMed

Tilapias are emerging as one of the most important fish in worldwide aquaculture and are also widely used as model fish in the study of reproduction and behavior. During the reproductive season, male tilapia are highly territorial and form spawning pits in which the dominant males court and spawn with available females. Non-territorial males stand a much lower chance of reproducing. Using transgenic tilapia in which follicle stimulating hormone (FSH) gonadotrophs were fluorescently labeled with enhanced green fluorescent protein (EGFP), we studied the effect of social dominance on the hormonal profile and pituitary cell populations in dominant and non-dominant males. Immunofluorescence studies showed that FSH-EGFP-transgenic fish reliably express EGFP in FSH-secreting cells. EGFP expression pattern differed from that of luteinizing hormone. Dominant males had larger gonads as well as higher levels of androgens and gonadotropins in the plasma. Pituitaries of dominant males exhibited higher gonadotropin content and gene expression. Flow cytometry revealed pituitary hyperplasia as well as FSH cell hyperplasia and increased granulation. Taken together, these findings suggest that gonadotroph hyperplasia as well as increased production by individual cells underlie the increased reproductive activity of dominant tilapia males. PMID:23660448

Golan, Matan; Levavi-Sivan, Berta

2013-10-01

324

Epithelial hyperplasia in human polycystic kidney diseases. Its role in pathogenesis and risk of neoplasia.  

PubMed Central

The importance of tubular epithelial hyperplasia in polycystic kidney diseases has become apparent during the last decade. Micropapillary hyperplasia occurs in autosomal dominant polycystic kidney disease, in localized cystic disease, and in acquired cystic disease. Neoplastic or severely dysplastic epithelial hyperplasia occurs in von Hippel-Lindau disease. A histopathologically distinctive epithelial hyperplasia occurs in tuberous sclerosis. In each of these conditions, epithelial hyperplasia may be related to cyst formation and may also impose an increased risk of malignancy--a risk that seems to be highest in patients under treatment with long-term hemodialysis for end-stage kidney disease. Although hyperplasia in some of these diseases may share a common pathway of development, it is more probable that the histopathologic differences reflect different pathogenetic pathways that converge on a common endpoint. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 PMID:3310652

Bernstein, J.; Evan, A. P.; Gardner, K. D.

1987-01-01

325

Investigation of electroforming techniques. [fabrication of regeneratively cooled thrust chambers  

NASA Technical Reports Server (NTRS)

Copper and nickel electroforming was examined for the purpose of establishing the necessary processes and procedures for repeatable, successful fabrication of the outer structures of regeneratively cooled thrust chambers. The selection of electrolytes for copper and nickel deposition is described. The development studies performed to refine and complete the processes necessary for successful chamber shell fabrication and the testing employed to verify the applicability of the processes and procedures to small scale hardware are described. Specifications were developed to afford a guideline for the electroforming of high quality outer shells on regeneratively cooled thrust chamber liners. Test results indicated repeatable mechanical properties could be produced in copper deposits from the copper sulfate electrolyte with periodic current reversal and in nickel deposits from the sulfamate solution. Use of inert, removable channel fillers and the conductivizing of such is described. Techniques (verified by test) which produce high integrity bonds to copper and copper alloy liners are discussed.

Malone, G. A.

1975-01-01

326

Trends in the stem cell and regenerative medicine industry.  

PubMed

The World Stem Cell Regenerative Medicine Congress series, now in its 7th year, is organized annually in the USA, Europe and Asia by Terrapinn, a business media company with its head office in London, and has grown over the last several years into the largest and probably the most important strategic stem cell conference where regulators, investors, big pharma, and small and medium enterprises gather to share and create synergy in developing and commercializing stem cell applications. The conference, held in London on 21-23 May 2012, only confirmed that this series is the meeting to attend if you want to get a clear understanding of trends in the stem cell and regenerative medicine industry. PMID:22954435

Ilic, Dusko

2012-09-01

327

Regenerative Fuel Cell Test Rig at Glenn Research Center  

NASA Technical Reports Server (NTRS)

The regenerative fuel cell development effort at Glenn Research Center (GRC) involves the integration of a dedicated fuel cell and electrolyzer into an energy storage system test rig. The test rig consists of a fuel cell stack, an electrolysis stack, cooling pumps, a water transfer pump, gas recirculation pumps, phase separators, storage tanks for oxygen (O2) and hydrogen (H2), heat exchangers, isolation valves, pressure regulators, interconnecting tubing, nitrogen purge provisions, and instrumentation for control and monitoring purposes. The regenerative fuel cell (RFC) thus formed is a completely closed system which is capable of autonomous cyclic operation. The test rig provides direct current (DC) load and DC power supply to simulate power consumption and solar power input. In addition, chillers are used as the heat sink to dissipate the waste heat from the electrochemical stack operation. Various vents and nitrogen (N2) sources are included in case inert purging is necessary to safe the RFC test rig.

Chang, Bei-Jiann; Johnson, Donald W.; Garcia, Christopher P.; Jakupca, Ian J.; Scullin, Vincent J.; Bents, David J.

2003-01-01

328

Regenerative Medicinal Chemistry: The in Situ Control of Stem Cells  

PubMed Central

In recent years, there has been mounting evidence to support the presence of stem and progenitor cells within many adult tissues that retain the capacity to proliferate and differentiate, thereby contributing to tissue homeostasis and repair. In line with these discoveries, there have been increasing efforts to develop new agents that target these resident stem and progenitor cell populations in situ to augment or to stimulate repair and regeneration processes. Two such agents are approved drugs, and several more are currently in clinical and preclinical development. Through this emerging therapeutic paradigm there is enormous scope for medicinal chemistry to play a pivotal role in regenerative medicine. The potential impact of regenerative medicinal chemistry is profound, and future studies will reveal which tissue types or disease states will prove most readily tractable through this approach. PMID:24900675

2013-01-01

329

Regenerative medicinal chemistry: the in situ control of stem cells.  

PubMed

In recent years, there has been mounting evidence to support the presence of stem and progenitor cells within many adult tissues that retain the capacity to proliferate and differentiate, thereby contributing to tissue homeostasis and repair. In line with these discoveries, there have been increasing efforts to develop new agents that target these resident stem and progenitor cell populations in situ to augment or to stimulate repair and regeneration processes. Two such agents are approved drugs, and several more are currently in clinical and preclinical development. Through this emerging therapeutic paradigm there is enormous scope for medicinal chemistry to play a pivotal role in regenerative medicine. The potential impact of regenerative medicinal chemistry is profound, and future studies will reveal which tissue types or disease states will prove most readily tractable through this approach. PMID:24900675

Russell, Angela J

2013-04-11

330

Nanotechnologies and regenerative medical approaches for space and terrestrial medicine.  

PubMed

One purpose of the International Space Station (ISS) is to explore powerful new areas of biomedical science in microgravity. Recent advances in nanotechnology applied to medicine--what we now refer to as nano-medicine--and regenerative medicine have enormous untapped potential for future space and terrestrial medical applications. Novel means for drug delivery and nanoscale screening tools will one day benefit astronauts venturing to Mars and places beyond, while the space laboratory will foster advances in nanotechnologies for diagnostic and therapeutic tools to help our patients here on Earth. Herein we review a series of nanotechnologies and selected regenerative medical approaches and highlight key areas of ongoing and future investigation that will benefit both space and terrestrial medicine. These studies target significant areas of human disease such as osteoporosis, diabetes, radiation injury, and many others. PMID:23156089

Grattoni, Alessandro; Tasciotti, Ennio; Fine, Daniel; Fernandez-Moure, Joseph S; Sakamoto, Jason; Hu, Ye; Weiner, Bradley; Ferrari, Mauro; Parazynski, Scott

2012-11-01

331

Spacecraft Radiator Freeze Protection Using a Regenerative Heat Exchanger  

NASA Technical Reports Server (NTRS)

An active thermal control system architecture has been modified to include a regenerative heat exchanger (regenerator) inboard of the radiator. Rather than using a radiator bypass valve a regenerative heat exchanger is placed inboard of the radiators. A regenerator cold side bypass valve is used to set the return temperature. During operation, the regenerator bypass flow is varied, mixing cold radiator return fluid and warm regenerator outlet fluid to maintain the system setpoint. At the lowest heat load for stable operation, the bypass flow is closed off, sending all of the flow through the regenerator. This lowers the radiator inlet temperature well below the system set-point while maintaining full flow through the radiators. By using a regenerator bypass flow control to maintain system setpoint, the required minimum heat load to avoid radiator freezing can be reduced by more than half compared to a radiator bypass system.

Ungar, Eugene K.; Schunk, Richard G.

2011-01-01

332

Regenerative Environmental Control and Life Support System Diagram  

NASA Technical Reports Server (NTRS)

This diagram shows the flow of recyclable resources in the International Space Station (ISS). The Environmental Control and Life Support System (ECLSS) Group of the Flight Projects Directorate at the Marshall Space Flight Center is responsible for the regenerative ECLSS hardware, as well as providing technical support for the rest of the system. The regenerative ECLSS, whose main components are the Water Recovery System (WRS), and the Oxygen Generation System (OGS), reclaims and recycles water and oxygen. The ECLSS maintains a pressurized habitation environment, provides water recovery and storage, maintains and provides fire detection / suppression, and provides breathable air and a comfortable atmosphere in which to live and work within the ISS. The ECLSS hardware will be located in the Node 3 module of the ISS.

2000-01-01

333

Multi-objective nonlinear control of semiactive and regenerative systems  

Microsoft Academic Search

Many modern structural control devices for earthquake engineering applications are essentially passive devices with adaptive parameters. Semiactive and regenerative forcing systems are two examples. In order to achieve performance superior to time-invariant passive systems, these devices must be controlled in the nonlinear regime, and consequently it is nontrivial to develop feedback controllers which adhere to analytically-computable measures of closed-loop performance.

J. T. Scruggs

2010-01-01

334

Cr:LiSrAlF(6) regenerative amplifier.  

PubMed

The design and performance of a flash-lamp-pumped regenerative amplifier that utilizes the new laser material Cr:LiSrAlF(6) is described. The device can be used for tunable and/or short-pulse amplification to the 10-mJ level at a repetition rate of 10 Hz. Using chirped-pulse amplification, we have achieved 8-mJ pulses with a duration of 150 fs. PMID:19794572

Perry, M D; Strickland, D; Ditmire, T; Patterson, F G

1992-04-15

335

On the Genealogy of Tissue Engineering and Regenerative Medicine  

PubMed Central

In this article, we identify and discuss a timeline of historical events and scientific breakthroughs that shaped the principles of tissue engineering and regenerative medicine (TERM). We explore the origins of TERM concepts in myths, their application in the ancient era, their resurgence during Enlightenment, and, finally, their systematic codification into an emerging scientific and technological framework in recent past. The development of computational/mathematical approaches in TERM is also briefly discussed. PMID:25343302

2015-01-01

336

A study of high-frequency regenerative frequency dividers  

Microsoft Academic Search

A comprehensive analytical study of high-frequency regenerative frequency dividers (RFD) is presented. The study includes two fundamental modes of operation in RFDs, namely stable and pulled operation modes. Differential equations characterizing the RFD behavior for both operation modes are derived. Next, an RFD circuit is designed and simulated in a 0.18µ µ µ µm standard CMOS process. Simulations verify the

Amin Q. Safarian; Payam Heydari

2005-01-01

337

Testing a Regenerative Carbon Dioxide and Moisture Removal Technology  

Microsoft Academic Search

The National Aeronautics and Space Administration supported the development of a new vacuum-desorbed regenerative carbon dioxide and humidity control technology for use in short duration human spacecraft. The technology was baselined for use in the Orion Crew Exploration Vehicle's Environmental Control and Life Support System (ECLSS). Termed the Carbon Diox-ide And Moisture Removal Amine Swing-bed (CAMRAS), the unit was developed

Daniel J. Barta; Amy Button; Jeffrey Sweterlitsch; Suzanne Curley

2010-01-01

338

On the genealogy of tissue engineering and regenerative medicine.  

PubMed

In this article, we identify and discuss a timeline of historical events and scientific breakthroughs that shaped the principles of tissue engineering and regenerative medicine (TERM). We explore the origins of TERM concepts in myths, their application in the ancient era, their resurgence during Enlightenment, and, finally, their systematic codification into an emerging scientific and technological framework in recent past. The development of computational/mathematical approaches in TERM is also briefly discussed. PMID:25343302

Kaul, Himanshu; Ventikos, Yiannis

2015-04-01

339

Tissue engineering and regenerative medicine research perspectives for pediatric surgery  

Microsoft Academic Search

Tissue engineering and regenerative medicine research is being aggressively pursued in attempts to develop biological substitutes\\u000a to replace lost tissue or organs. Remarkable degrees of success have been achieved in the generation of a variety of tissues\\u000a and organs as a result of concerted contributions by multidisciplinary groups in the field of biotechnology. Engineering of\\u000a an organ is a complex

Amulya K. Saxena

2010-01-01

340

The Ovonic Regenerative Fuel Cell, A Fundamentally New Approach  

NSDL National Science Digital Library

This report introduces the Ovonic Regenerative fuel cell, which is a technology that "utilizes Ovonic metal hydride materials in place of traditional noble metal catalysts in the hydrogen fuel electrode." The paper goes into detail about how these fuel cells work and includes graphical representations of the processes involved. This paper was presented at the Hydrogen and Fuel Cells 2004 Conference and Trade Show in Toronto, Canada. This document may be downloaded in PDF file format.

Corrigan, D.A.

341

A graphite-lined regeneratively cooled thrust chamber  

NASA Technical Reports Server (NTRS)

Design concepts, based on use of graphite as a thermal barrier for regeneratively cooled FLOX-methane thrust chambers, have been screened and concepts selected for detailed thermodynamic, stress, and fabrication analyses. A single design employing AGCarb-101, a fibrous graphite composite material, for a thermal barrier liner and an electroformed nickel structure with integral coolant passages was selected for fabrication and testing. The fabrication processes and the test results are described and illustrated.

Stubbs, V. R.

1972-01-01

342

Alexandrite-pumped alexandrite regenerative amplifier for femtosecond pulse amplification  

Microsoft Academic Search

We demonstrate a regenerative amplifier incorporating alexandrite as the gain medium that is pumped by an alexandrite laser. Temperature-altered gain permitted the 728-nm alexandrite pump laser, operating at room temperature, to pump a 780â800-nm alexandrite laser that was maintained at elevated temperatures. 200-fs pulses from a Ti:sapphire oscillator were amplified to the millijoule level. This system also amplified femtosecond pulses

A. Hariharan; M. E. Fermann; M. L. Stock; D. J. Harter; Jeff Squier

1996-01-01

343

Regenerative amplification in alexandrite of pulses from specialized oscillators  

SciTech Connect

The authors describe an alexandrite regenerative amplifier used to amplify the output of various specialized oscillators. Nanosecond pulses from a narrow frequency CW-pumped dye laser, picosecond pulses from a gain-switched diode laser, and femtosecond pulses from a synchronously pumped dye laser were amplified by six-ten orders of magnitude in a single stage while conserving the temporal and spectral profiles characteristic to the oscillators.

Bado, P.; Pessot, M.; Squier, J.; Mourou, G.A.; Harter, D.J.

1988-06-01

344

Hydrogen-Oxygen PEM Regenerative Fuel Cell Energy Storage System  

NASA Technical Reports Server (NTRS)

An introduction to the closed cycle hydrogen-oxygen polymer electrolyte membrane (PEM) regenerative fuel cell (RFC), recently constructed at NASA Glenn Research Center, is presented. Illustrated with explanatory graphics and figures, this report outlines the engineering motivations for the RFC as a solar energy storage device, the system requirements, layout and hardware detail of the RFC unit at NASA Glenn, the construction history, and test experience accumulated to date with this unit.

Bents, David J.; Scullin, Vincent J.; Chang, Bei-Jiann; Johnson, Donald W.; Garcia, Christopher P.

2005-01-01

345

Design of a regenerative fuel cell system for Space Station  

NASA Technical Reports Server (NTRS)

The NASA Space Station will employ alkaline regenerative fuel cells (RFCs) as its sole electrochemical energy storage system, in virtue of demonstrated technology readiness and a high degree of system-level design flexibility. NASA Johnson and NASA Lewis are currently engaged in the development of a 10-kW alkaline engineering model system, for 1987 delivery, which will encompass a fully autonomous 120-V system with 55 percent overall electrical efficiency and a 20,000-hr service life.

Hoberecht, M. A.; Rieker, L. L.

1985-01-01

346

Regen compressors power Capo Bon trans-med station  

SciTech Connect

It is expected that Algeria will begin deliveries of natural gas from the Hassi-R'Mel gasfield in the Sahara Desert to Italy by the end of 1981 or early 1982. The main station for the Trans-Med natural gas pipeline, powered by five regenerative M5322R gas turbines, has a design throughput of some 1.6 million m/sup 3//hr and serves as the boost station for the submarine section of the pipeline.

de Biasi, V.

1981-11-01

347

The Application of Microwave Incineration to Regenerative Life Support  

NASA Technical Reports Server (NTRS)

Future human exploration missions will require life support systems that are highly regenerative, requiring minimum resupply, enabling the crews to be largely self-sufficient. Solid wastes generated in space will be processed to recover usable material. Researchers at NASA Ames Research Center are studying a commercially-produced microwave incinerator as a solid waste processor. This paper will describe the results of testing to-date.

Sun, Sidney C.; Srinivasan, Venkatesh; Covington, Al (Technical Monitor)

1995-01-01

348

Unitized Regenerative Fuel Cell System Dryer-Humidifier Analytical Model Development  

NASA Technical Reports Server (NTRS)

A Unitized Regenerative Fuel Cell (URFC) Energy Storage System is being developed at the NASA Glenn Research Center. This URFC system is unique in that it uses regenerative gas dryers/humidifiers that are mounted on the surface of the gas storage tanks that act as the radiators for thermal control of the URFC system. As the gas storage tanks cool down during URFC charging the regenerative gas dryers/humidifiers dry the hydrogen and oxygen gases produced by electrolysis. As the gas storage tanks heat up during URFC discharging, the regenerative gas dryers/humidifiers humidify the hydrogen and oxygen gases used by fuel cell. An analytical model was developed to simulate the URFC system's regenerative gas dryers/humidifiers. The model is in the form of an EXCEL@ worksheet that allows the investigation of the regenerative gas dryers/humidifier performance as a function of time and position within the regenerative gas dryers/humidifiers, as well as other key system variables. Finite Element Analysis (FEA) modeling of the regenerative gas dryers/humidifier and gas storage tank wall was also done to analyze spatial temperature distribution within the regenerative gas dryers/humidifiers and the localized tank wall. Test results obtained from the testing of the regenerative gas dryers/humidifiers in a thermal vacuum environment were used to corroborate the analyses.

Burke, Kenneth A.; Jakupca, Ian

2003-01-01

349

Potential regenerative treatment strategies for intervertebral disc degeneration in dogs  

PubMed Central

Pain due to spontaneous intervertebral disc (IVD) disease is common in dogs. In chondrodystrophic (CD) dogs, IVD disease typically develops in the cervical or thoracolumbar spine at about 3–7 years of age, whereas in non-chondrodystrophic (NCD) dogs, it usually develops in the caudal cervical or lumbosacral spine at about 6–8 years of age. IVD degeneration is characterized by changes in the biochemical composition and mechanical integrity of the IVD. In the degenerated IVD, the content of glycosaminoglycan (GAG, a proteoglycan side chain) decreases and that of denatured collagen increases. Dehydration leads to tearing of the annulus fibrosus (AF) and/or disc herniation, which is clinically characterized by pain and/or neurological signs. Current treatments (physiotherapy, anti-inflammatory/analgesic medication, surgery) for IVD disease may resolve neurological deficits and reduce pain (although in many cases insufficient), but do not lead to repair of the degenerated disc. For this reason, there is interest in new regenerative therapies that can repair the degenerated disc matrix, resulting in restoration of the biomechanical function of the IVD. CD dogs are considered a suitable animal model for human IVD degeneration because of their spontaneous IVD degeneration, and therefore studies investigating cell-, growth factor-, and/or gene therapy-based regenerative therapies with this model provide information relevant to both human and canine patients. The aim of this article is to review potential regenerative treatment strategies for canine IVD degeneration, with specific emphasis on cell-based strategies. PMID:24387033

2014-01-01

350

Regenerative medicine in Europe: global competition and innovation governance.  

PubMed

Leading European nations with strong biotech sectors, such as the UK and Germany, are investing heavily in regenerative medicine, seeking competitive advantage in this emerging sector. However, in the broader biopharmaceutical sector, the EU is outperformed by the USA on all metrics, reflecting longstanding problems: limited venture capital finance, a fragmented patent system, and relatively weak relations between academia and industry. The current global downturn has exacerbated these difficulties. The crisis comes at a time when the EU is reframing its approach to the governance of innovation and renewing its commitment to the goal of making Europe the leading player in the global knowledge economy. If the EU is to gain a competitive advantage in the regenerative medicine sector then it must coordinate a complex multilevel governance framework that encompasses the EU, member states and regional authorities. This article takes stock of Europe's current competitive position within the global bioeconomy, drawing on a variety of metrics in the three intersecting spheres of innovation governance: science, market and society. These data then provide a platform for reviewing the problems of innovation governance faced by the EU and the strategic choices that have to be confronted in the regenerative medicine sector. PMID:21082895

Hogarth, Stuart; Salter, Brian

2010-11-01

351

Potential regenerative treatment strategies for intervertebral disc degeneration in dogs.  

PubMed

Pain due to spontaneous intervertebral disc (IVD) disease is common in dogs. In chondrodystrophic (CD) dogs, IVD disease typically develops in the cervical or thoracolumbar spine at about 3-7 years of age, whereas in non-chondrodystrophic (NCD) dogs, it usually develops in the caudal cervical or lumbosacral spine at about 6-8 years of age. IVD degeneration is characterized by changes in the biochemical composition and mechanical integrity of the IVD. In the degenerated IVD, the content of glycosaminoglycan (GAG, a proteoglycan side chain) decreases and that of denatured collagen increases. Dehydration leads to tearing of the annulus fibrosus (AF) and/or disc herniation, which is clinically characterized by pain and/or neurological signs. Current treatments (physiotherapy, anti-inflammatory/analgesic medication, surgery) for IVD disease may resolve neurological deficits and reduce pain (although in many cases insufficient), but do not lead to repair of the degenerated disc. For this reason, there is interest in new regenerative therapies that can repair the degenerated disc matrix, resulting in restoration of the biomechanical function of the IVD. CD dogs are considered a suitable animal model for human IVD degeneration because of their spontaneous IVD degeneration, and therefore studies investigating cell-, growth factor-, and/or gene therapy-based regenerative therapies with this model provide information relevant to both human and canine patients. The aim of this article is to review potential regenerative treatment strategies for canine IVD degeneration, with specific emphasis on cell-based strategies. PMID:24387033

Bach, Frances C; Willems, Nicole; Penning, Louis C; Ito, Keita; Meij, Björn P; Tryfonidou, Marianna A

2014-01-01

352

The Functional Role of Reactive Stroma in Benign Prostatic Hyperplasia  

PubMed Central

The human prostate gland is one of the only internal organs that continue to enlarge throughout adulthood. The specific mechanisms that regulate this growth, as well as the pathological changes leading to the phenotype observed in the disease benign prostatic hyperplasia (BPH), are essentially unknown. Recent studies and their associated findings have made clear that many complex alterations occur, involving persistent and chronic inflammation, circulating hormonal level deregulation, and aberrant wound repair processes. BPH has been etiologically characterized as a progressive, albeit discontinuous, hyperplasia of both the glandular epithelial and stromal cell compartments coordinately yielding an expansion of the prostate gland and clinical symptoms. Interestingly, the inflammatory and repair responses observed in BPH are also key components of general wound repair in post-natal tissues. These responses include altered expression of chemokines, cytokines, matrix remodeling factors, chronic inflammatory processes, altered immune surveillance and recognition, as well as the formation of a prototypical ‘reactive’ stroma which is similar to that observed across various fibroplasias and malignancies of a variety of tissue sites. Stromal tissue, both embryonic mesenchyme, and adult reactive stroma myofibroblasts, has been shown to exert potent and functional regulatory control over epithelial proliferation and differentiation as well as immunoresponsive modulation. Thus, the functional biology of a reactive stroma, within the context of an adult disease typified by epithelial and stromal aberrant hyperplasia, is critical to understand within the context of prostate disease and beyond. The mechanisms that regulate reactive stroma biology in BPH represent targets of opportunity for new therapeutic approaches that may extend to other tissue contexts. Accordingly, this review seeks to address the dissection of important factors, signaling pathways, genes, and other regulatory components that mediate the interplay between epithelium and stromal responses in BPH. PMID:21664759

Schauer, Isaiah G.; Rowley, David R.

2011-01-01

353

Parathyroid hyperplasia of auto-transplanted tissue in forearm skin.  

PubMed

Currently, the treatment of choice for refractory tertiary hyperparathyroidism is a total parathyroidectomy with autotransplantation of the parathyroid tissue into the forearm. Recurrent hyperparathyroidism after autotransplantation requiring surgical excision of the autograft is uncommon. We describe a female patient with recurrent hyperplasia who underwent an excision of her parathyroid autograft. The excisional specimen was submitted to pathology with the only provided history of a 'left arm mass'. The lack of clinical history led to a preliminary impression of an adnexal neoplasm by the primary pathologist. PMID:19723138

Padgett, Sabrina N; Walsh, Sarah N; Santa Cruz, Daniel J

2011-02-01

354

Angiolymphoid hyperplasia with eosinophilia involving the cubital nerve.  

PubMed

A tumor involving cubital nerve was resected and studied; it was classified as an angiolymphoid hyperplasia with eosinophilia (ALHE). Immunohistochemical and molecular study was done both to confirm the reactive nature of the process and rule out the presence of clonal T or B cell rearrangement. This lesion has been designated as epitheloid hemangioma [Coindre (1994) Ann Pathol 14:426]. Typically, ALHE occurs in the skin and the subcutaneous tissue, and extracutaneous involvement is rare. No cases of ALHE affecting a nerve have been described, but a case of Kimura's disease, the lesions of which have repeatedly been confused with ALHE, has been reported involving median nerve. PMID:14762674

Martorell, Miguel; Pérez-Vallés, Ana; García-García, Jose Angel; Calabuig, Consuelo; Aguilella, Luis

2004-04-01

355

Disseminated angiolymphoid hyperplasia with eosinophilia: a case report.  

PubMed

A 37-year-old Cantonese man presented with pruritic erythematous papules and nodules on his face, limbs, and trunk that had been present for 10 years and aggravated for 2 years. More nodules were noticed where the skin was scratched and traumatized. The lesions were alleviated temporarily, but they did not subside entirely without therapy. The lesions responded to treatment with intravenous dexamethasone. Histopathology results indicated angiolymphoid hyperplasia with eosinophilia (ALHE), and the patient was diagnosed with disseminated ALHE (DALHE). His lesions ameliorated after treatment with prednisone. PMID:14604086

Zhang, Guo-Yi; Jiang, Juan; Lin, Tong; Wang, Qian-Qiu

2003-10-01

356

An Intrinsic MicroRNA Timer Regulates Progressive Decline in Shoot Regenerative Capacity in Plants.  

PubMed

Plant cells are totipotent and competent to regenerate from differentiated organs. It has been shown that two phytohormones, auxin and cytokinin, play critical roles within this process. As in animals, the regenerative capacity declines with age in plants, but the molecular basis for this phenomenon remains elusive. Here, we demonstrate that an age-regulated microRNA, miR156, regulates shoot regenerative capacity. As a plant ages, the gradual increase in miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors leads to the progressive decline in shoot regenerative capacity. In old plants, SPL reduces shoot regenerative capacity by attenuating the cytokinin response through binding with the B-type ARABIDOPSIS RESPONSE REGULATORs, which encode the transcriptional activators in the cytokinin signaling pathway. Consistently, the increased amount of exogenous cytokinin complements the reduced shoot regenerative capacity in old plants. Therefore, the recruitment of age cues in response to cytokinin contributes to shoot regenerative competence. PMID:25649435

Zhang, Tian-Qi; Lian, Heng; Tang, Hongbo; Dolezal, Karel; Zhou, Chuan-Miao; Yu, Sha; Chen, Juan-Hua; Chen, Qi; Liu, Hongtao; Ljung, Karin; Wang, Jia-Wei

2015-02-01

357

Pathophysiology of parathyroid hyperplasia in chronic kidney disease: preclinical and clinical basis for parathyroid intervention  

Microsoft Academic Search

Secondary hyperparathyroidism is characterised by ex- cessive secretion of parathyroid hormone and parathy- roid hyperplasia, resulting in both skeletal and extraskele- tal consequences. Recent basic and clinical studies have brought considerable advances in our understanding of the pathophysiology of parathyroid hyperplasia and have also provided practical therapeutic approaches, especially with regard to indications for parathyroid intervention. In this context, it

Shunsuke Goto; Hirotaka Komaba; Masafumi Fukagawa

2008-01-01

358

Substitution therapy in adult patients with congenital adrenal hyperplasia.  

PubMed

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive inherited disorders caused by defective steroidogenesis. Steroid 21-hydroxylase deficiency (21OHD) is its most prevalent form, accounting for over 90% of all cases. Clinically classic 21OHD is characterised by glucocorticoid deficiency and adrenal androgen excess with (salt wasting form) or without (simple virilising form) additional mineralocorticoid deficiency. Life-saving glucocorticoid substitution therapy has been available since the 1950s and enables long-term survival, and potentially, a good quality of life. However, care of adult patients with classic congenital adrenal hyperplasia is challenging for two main reasons: firstly, there is no glucocorticoid preparation available mimicking circadian cortisol release and adaptation to stress and secondly, management of adult patients is still in its infancy. There is no evidence-based treatment and experienced centres, taking care of larger patient cohorts, are only emerging. In this article we aim to guide physicians on the treatment and monitoring of adult patients with 21OHD, based on the clinical studies available and our own clinical experience. PMID:25617171

Reisch, Nicole

2015-01-01

359

Cushing's syndrome secondary to ACTH-independent macronodular adrenal hyperplasia.  

PubMed

ACTH-Independent macronodular adrenal hyperplasia (AIMAH) is a rare cause of endogenous Cushing's syndrome (CS), in which clinical features usually become apparent only after several decades of life. This form of adrenal hyperplasia typically produces excess cortisol with overt or subclinical CS, but concurrent secretion of mineralocorticoids or sexual steroids can also occur. The diagnosis is suspected by bilateral adrenal nodules larger than 1 cm on incidental imaging studies or following the demonstration of ACTH-independent hormonal hypersecretion. The pathophysiology of this entity is heterogeneous and has been intensely explored in recent years. Several G-protein coupled receptors aberrantly expressed in the adrenal cortex have been implicated in the regulation of steroidogenesis and in the initial cell proliferation in AIMAH. Several familial cases of AIMAH have been recently described with the same pattern of aberrant hormone receptors in all affected members of the family. It is probable that additional somatic genetic events related to cell cycle regulation, adhesion and transcription factors occur in addition over time in the various nodules; other mechanisms, as Gsp or ACTH receptor mutations and paracrine adrenal hormonal secretion have been rarely identified as the molecular mechanism in some cases. When systematically screened, most patients with AIMAH exhibit an in vivo aberrant cortisol response to one or various ligands suggesting the presence of aberrant adrenal receptors. The identification of these receptors creates the possibility of a specific pharmacological treatment isolated or associated with adrenalectomy. PMID:18209860

Costa, Marcia Helena Soares; Lacroix, André

2007-11-01

360

New advances in benign prostatic hyperplasia: laser therapy.  

PubMed

Throughout the past decade, numerous techniques for the treatment of benign prostatic hyperplasia have emerged. Laser therapy, in particular, has gained widespread popularity among urologists. Since its inception in 1996, holmium laser enucleation of the prostate (HoLEP) has been evaluated rigorously in the treatment of glands of all sizes. HoLEP has produced superior relief of bladder outlet obstruction as compared to transurethral resection of the prostate based on urodynamics, and has proved equally as effective as open prostatectomy, for the management of very large glands (>100 cc), with lower morbidity. In addition to HoLEP, several newer but less well-studied laser techniques currently are available. These include photoselective laser vaporization utilizing the potassium-titanyl-phosphate (KTP or "green light") laser, thulium laser enucleation, and high-power diode laser vaporization. This report reviews the most current literature on laser therapies utilized in the treatment of benign prostatic hyperplasia with regards to safety, outcome, efficiency, and long-term durability. PMID:21088938

Mandeville, Jessica; Gnessin, Ehud; Lingeman, James E

2011-02-01

361

Benign prostatic hyperplasia and urinary symptoms: Evaluation and treatment.  

PubMed

Benign prostatic hyperplasia (BPH) is one of the most common conditions affecting middle-aged men. This condition can be microscopic, macroscopic, symptomatic, or asymptomatic. Up to 15% to 25% of men aged 50-65 years have lower urinary tract symptoms (LUTS) consisting of nocturia, urgency, frequency, a sensation of not completely emptying the bladder, stop-start urination, straining to urinate, a need to urinate soon after voiding, and weak urinary stream. These symptoms usually are associated with benign enlargement of the prostate gland that is of sufficient severity to interfere with a man's quality of life. Although LUTS is often associated with BPH, LUTS can also be due to various unrelated syndromes such as heart failure, urinary tract infections, and diabetes. Most men will have benign hyperplasia of the prostate gland and this benign growth compresses the urethra resulting in LUTS. This article will discuss the evaluation, pharmacological management, minimally invasive treatment, and surgical therapy of this common condition affecting millions of American men. PMID:25823641

Mobley, David; Feibus, Allison; Baum, Neil

2015-04-01

362

Altered catecholamine receptor affinity in rabbit aortic intimal hyperplasia  

SciTech Connect

Intimal thickening is a universal response to endothelial denudation and is also thought to be a precursor of atherosclerosis. The authors have demonstrated selective supersensitivity in arterial intimal hyperplasia to norepinephrine and they now report a possible mechanism for this. Binding studies in rabbit aorta with the selective alpha 1-adrenergic radioligand 125I-HEAT demonstrated that there was no change in receptor density (20 {plus minus} 4 fmole/10(6) cells) in intact vascular smooth muscle cells at either 5 or 14 days after denudation. However, competition studies showed a 2.6-fold increase in alpha 1-adrenergic receptor affinity for norepinephrine in intimal hyperplastic tissue (P less than 0.05). This increased affinity for norepinephrine was associated with a greater increase in 32P-labeled phosphatidylinositol (148% intimal thickening versus 76% control) and phosphatidic acid (151% intimal thickening versus 56% control) following norepinephrine stimulation of free floating rings of intimal hyperplastic aorta. These data suggest that the catecholamine supersensitivity in rabbit aortic intimal hyperplasia is receptor mediated and may be linked to the phosphatidylinositol cycle.

O'Malley, M.K.; Cotecchia, S.; Hagen, P.O. (Duke University Medical Center, Durham, NC (USA))

1991-08-01

363

Fermented Dairy Products Modulate Citrobacter rodentium–Induced Colonic Hyperplasia  

PubMed Central

We evaluated the protective effects of fermented dairy products (FDPs) in an infection model, using the mouse pathogen Citrobacter rodentium (CR). Treatment of mice with FDP formulas A, B, and C or a control product did not affect CR colonization, organ specificity, or attaching and effacing lesion formation. Fermented dairy product A (FDP-A), but neither the supernatant from FDP-A nor ?-irradiated (IR) FDP-A, caused a significant reduction in colonic crypt hyperplasia and CR-associated pathology. Profiling the gut microbiota revealed that IR-FDP-A promoted higher levels of phylotypes belonging to Alcaligenaceae and a decrease in Lachnospiraceae (Ruminococcus) during CR infection. Conversely, FDP-A prevented a decrease in Ruminococcus and increased Turicibacteraceae (Turicibacter). Importantly, loss of Ruminococcus and Turicibacter has been associated with susceptibility to dextran sodium sulfate–induced colitis. Our results demonstrate that viable bacteria in FDP-A reduced CR-induced colonic crypt hyperplasia and prevented the loss of key bacterial genera that may contribute to disease pathology. PMID:24706936

Collins, James W.; Chervaux, Christian; Raymond, Benoit; Derrien, Muriel; Brazeilles, Rémi; Kosta, Artemis; Chambaud, Isabelle; Crepin, Valerie F.; Frankel, Gad

2014-01-01

364

Integration of regenerative shock absorber into vehicle electric system  

NASA Astrophysics Data System (ADS)

Regenerative/Energy harvesting shock absorbers have a great potential to increase fuel efficiency and provide suspension damping simultaneously. In recent years there's intensive work on this topic, but most researches focus on electricity extraction from vibration and harvesting efficiency improvement. The integration of electricity generated from regenerative shock absorbers into vehicle electric system, which is very important to realize the fuel efficiency benefit, has not been investigated. This paper is to study and demonstrate the integration of regenerative shock absorber with vehicle alternator, battery and in-vehicle electrical load together. In the presented system, the shock absorber is excited by a shaker and it converts kinetic energy into electricity. The harvested electricity flows into a DC/DC converter which realizes two functions: controlling the shock absorber's damping and regulating the output voltage. The damping is tuned by controlling shock absorber's output current, which is also the input current of DC/DC converter. By adjusting the duty cycles of switches in the converter, its input impedance together with input current can be adjusted according to dynamic damping requirements. An automotive lead-acid battery is charged by the DC/DC converter's output. To simulate the working condition of combustion engine, an AC motor is used to drive a truck alternator, which also charges the battery. Power resistors are used as battery's electrical load to simulate in-vehicle electrical devices. Experimental results show that the proposed integration strategy can effectively utilize the harvested electricity and power consumption of the AC motor is decreased accordingly. This proves the combustion engine's load reduction and fuel efficiency improvement.

Zhang, Chongxiao; Li, Peng; Xing, Shaoxu; Kim, Junyoung; Yu, Liangyao; Zuo, Lei

2014-03-01

365

Cell/tissue processing information system for regenerative medicine.  

PubMed

When conducting clinical studies of regenerative medicine, compliance to good manufacturing practice (GMP) is mandatory, and thus much time is needed for manufacturing and quality management. It is therefore desired to introduce the manufacturing execution system (MES), which is being adopted by factories manufacturing pharmaceutical products. Meanwhile, in manufacturing human cell/tissue processing autologous products, it is necessary to protect patients' personal information, prevent patients from being identified and obtain information for cell/tissue identification. We therefore considered it difficult to adopt conventional MES to regenerative medicine-related clinical trials, and so developed novel software for production/quality management to be used in cell-processing centres (CPCs), conforming to GMP. Since this system satisfies the requirements of regulations in Japan and the USA for electronic records and electronic signatures (ER/ES), the use of ER/ES has been allowed, and the risk of contamination resulting from the use of recording paper has been eliminated, thanks to paperless operations within the CPC. Moreover, to reduce the risk of mix-up and cross-contamination due to contact during production, we developed a touchless input device with built-in radio frequency identification (RFID) reader-writer devices and optical sensors. The use of this system reduced the time to prepare and issue manufacturing instructions by 50% or more, compared to the conventional handwritten system. The system contributes to producing more large-scale production and to reducing production costs for cell and tissue products in regenerative medicine. Copyright © 2014 John Wiley & Sons, Ltd. PMID:24700532

Iwayama, Daisuke; Yamato, Masayuki; Tsubokura, Tetsuya; Takahashi, Minoru; Okano, Teruo

2014-04-01

366

Theoretical and experimental study on regenerative rotary displacer Stirling engine  

SciTech Connect

Recently a quite new type of hot air engine called rotary displacer engine, in which the displacer is a rotating disk enclosed in a cylinder, has been conceived and developed. The working gas, contained in a notch excavated in the disk, is heated and cooled alternately, on account of the heat transferred through the enclosing cylinder that is heated at one side and cooled at the opposite one. The gas temperature oscillations cause the pressure fluctuations that get out mechanical power acting on a power piston. In order to attempt to increase the performances for this kind of engine, the authors propose three different regeneration methods. The first one comprises two coaxial disks that, revolving in opposite ways, cause a temperature gradient on the cylinder wall and a regenerative axial heat conduction through fins shaped on the cylinder inner wall. The other two methods are based on the heat transferred by a proper closed circuit that in one case has a circulating liquid inside and in the other one is formed by several heat pipes working each one for different temperatures. An engine based on the first principle, the Regenerative Tandem Contra-Rotary Displacer Stirling Engine, has been realized and experimented. In this paper experimental results with and without regeneration are reported comparatively with a detailed description of the unity. A basic explanation of the working principle of this engine and a theoretical analysis investigating the main influential parameters for the regenerative effect are done. This new rotating displacer Stirling engines, for their simplicity, are expected to attain high rotational speed especially for applications as demonstration and hobby unities.

Raggi, L.; Katsuta, Masafumi [Waseda Univ., Tokyo (Japan); Isshiki, Naotsugu [Nihon Univ., Tokyo (Japan); Isshiki, Seita [Isshiki R and D Lab., Tokyo (Japan)

1997-12-31

367

Formed platelet liner concept for regeneratively cooled chambers  

NASA Technical Reports Server (NTRS)

A process for the fabrication of a formed platelet regeneratively cooled combustion chamber liner is described, and the benefits offered by the combustor liner are discussed. The advantages of using formed platelet combustor liners include a substantially increased cycle life and decreased coolant pressure drop in conjunction with low manufacturing costs. In the initial experiments, zirconium copper combustor liner sections with a hot gas wall thickness as small as 0.008 inch and channel aspect ratios of 15 have been achieved. It is also shown that HIP provides an excellent bonding technique for joining chamber liner panels.

Burkhardt, W. M.; Tobin, S. E.; Mueggenburg, H. H.

1990-01-01

368

Hybrid regenerative fuel cell systems for space applications  

NASA Technical Reports Server (NTRS)

This paper describes a hybrid regenerative fuel cell (RFC) system for space application, which is made up of an alkaline fuel cell (Space Shuttle fuel cell) and an acid electrolysis unit (solid polymer electrolyte). In the RFC, gas produced from the acid electrolysis unit and water produced by the alkaline fuel cell are repeatedly reacted in the other unit. The results of RFC's tests indicate that the system is feasible in terms of fluid/unit compatibility. In addition, the fuel cell thermal-control system proved capable of controlling fuel cell temperatures throughout long open-circuit periods. Diagrams of the RFC and its subsystems are included.

Saucier, David R.

1988-01-01

369

Engineering physical microenvironment for stem cell based regenerative medicine.  

PubMed

Regenerative medicine has rapidly evolved over the past decade owing to its potential applications to improve human health. Targeted differentiations of stem cells promise to regenerate a variety of tissues and/or organs despite significant challenges. Recent studies have demonstrated the vital role of the physical microenvironment in regulating stem cell fate and improving differentiation efficiency. In this review, we summarize the main physical cues that are crucial for controlling stem cell differentiation. Recent advances in the technologies for the construction of physical microenvironment and their implications in controlling stem cell fate are also highlighted. PMID:24508818

Han, Yu Long; Wang, Shuqi; Zhang, Xiaohui; Li, Yuhui; Huang, Guoyou; Qi, Hao; Pingguan-Murphy, Belinda; Li, Yinghui; Lu, Tian Jian; Xu, Feng

2014-06-01

370

A Possible Regenerative, Molten-Salt, Thermoelectric Fuel Cell  

NASA Technical Reports Server (NTRS)

Molten or fused salts have been evaluated as possible thermoelectric materials because of the relatively good values of their figures of merit, their chemical stability, their long liquid range, and their ability to operate in conjunction with a nuclear reactor to produce heat. In general, molten salts are electrolytic conductors; therefore, there will be a transport of materials and subsequent decomposition with the passage of an electric current. It is possible nonetheless to overcome this disadvantage by using the decomposition products of the molten-salt electrolyte in a fuel cell. The combination of a thermoelectric converter and a fuel cell would lead to a regenerative system that may be useful.

Greenberg, Jacob; Thaller, Lawrence H.; Weber, Donald E.

1964-01-01

371

Alexandrite-pumped alexandrite regenerative amplifier for femtosecond pulse amplification  

SciTech Connect

We demonstrate a regenerative amplifier incorporating alexandrite as the gain medium that is pumped by an alexandrite laser. Temperature-altered gain permitted the 728-nm alexandrite pump laser, operating at room temperature, to pump a 780{endash}800-nm alexandrite laser that was maintained at elevated temperatures. 200-fs pulses from a Ti:sapphire oscillator were amplified to the millijoule level. This system also amplified femtosecond pulses from a frequency-doubled Er-doped fiber laser. {copyright} {ital 1996 Optical Society of America.}

Hariharan, A.; Fermann, M.E.; Stock, M.L.; Harter, D.J. [IMRA America, Inc., 1044 Woodridge Avenue, Ann Arbor, Michigan 48105 (United States); Squier, J. [Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, California 92093-0339 (United States)

1996-01-01

372

An alexandrite regenerative amplifier for water vapor and temperature measurements  

NASA Technical Reports Server (NTRS)

The Differential Absorption Lidar (DIAL) technique is a powerful method for determining meteorological parameters, but it requires high quality of the laser source: high energy, very narrow bandwidth, high wavelength stability, and spectral purity. Although many efforts have been made to improve the lasers in view of these aspects, a satisfactory solution has not been demonstrated up to now. We describe a regenerative amplifier, using a Ti:sapphire laser as master oscillator and an alexandrite laser as slave amplifier, which is expected to meet the requirements for water vapor concentration and temperature measurements.

Thro, P.-Y.; Boesenberg, J.; Wulfmeyer, V.

1992-01-01

373

High Pressure Regenerative Turbine Engine: 21st Century Propulsion  

NASA Technical Reports Server (NTRS)

A novel semi-closed cycle gas turbine engine was demonstrated and was found to meet the program goals. The proof-of-principle test of the High Pressure Regenerative Turbine Engine produced data that agreed well with models, enabling more confidence in designing future prototypes based on this concept. Emission levels were significantly reduced as predicted as a natural attribute of this power cycle. Engine testing over a portion of the operating range allowed verification of predicted power increases compared to the baseline.

Lear, W. E.; Laganelli, A. L.; Senick, Paul (Technical Monitor)

2001-01-01

374

Regeneratively cooled rocket engine for space storable propellants  

NASA Technical Reports Server (NTRS)

Analysis, design, fabrication, and test efforts were performed for the existing OF2/B2H6 regeneratively cooled lK (4448 N) thrust chamber to illustrate simultaneous B2H6 fuel and OF2 oxidizer cooling and to provide results for a gaseous propellant condition injected into the combustion chamber. Data derived from performance, thermal and flow measurements confirmed predictions derived from previous test work and from concurrent analytical study. Development data derived from the experimental study were indicated to be sufficient to develop a preflight thrust chamber demonstrator prototype for future space mission objectives.

Wagner, W. R.

1973-01-01

375

Precision manufacturing for clinical-quality regenerative medicines.  

PubMed

Innovations in engineering applied to healthcare make a significant difference to people's lives. Market growth is guaranteed by demographics. Regulation and requirements for good manufacturing practice-extreme levels of repeatability and reliability-demand high-precision process and measurement solutions. Emerging technologies using living biological materials add complexity. This paper presents some results of work demonstrating the precision automated manufacture of living materials, particularly the expansion of populations of human stem cells for therapeutic use as regenerative medicines. The paper also describes quality engineering techniques for precision process design and improvement, and identifies the requirements for manufacturing technology and measurement systems evolution for such therapies. PMID:22802496

Williams, David J; Thomas, Robert J; Hourd, Paul C; Chandra, Amit; Ratcliffe, Elizabeth; Liu, Yang; Rayment, Erin A; Archer, J Richard

2012-08-28

376

Complement-triggered pathways orchestrate regenerative responses throughout phylogenesis  

PubMed Central

Adult tissue plasticity, cell reprogramming, and organ regeneration are major challenges in the field of modern regenerative medicine. Devising strategies to increase the regenerative capacity of tissues holds great promise for dealing with donor organ shortages and low transplantation outcomes and also provides essential impetus to tissue bioengineering approaches for organ repair and replacement. The inherent ability of cells to reprogram their fate by switching into an embryonic-like, pluripotent progenitor state is an evolutionary vestige that in mammals has been retained mostly in fetal tissues and persists only in a few organs of the adult body. Tissue regeneration reflects the capacity of terminally differentiated cells to re-enter the cell cycle and proliferate in response to acute injury or environmental stress signals. In lower vertebrates, this regenerative capacity extends to several organs and remarkably culminates in precise tissue patterning, through cellular transdifferentiation and complex morphogenetic processes that can faithfully reconstruct entire body parts. Many lessons have been learned from robust regeneration models in amphibians such as the newt and axolotl. However, the dynamic interactions between the regenerating tissue, the surrounding stroma, and the host immune response, as it adapts to the actively proliferating tissue, remain ill-defined. The regenerating zone, through a sequence of distinct molecular events, adopts phenotypic plasticity and undergoes rigorous tissue remodeling that, in turn, evokes a significant inflammatory response. Complement is a primordial sentinel of the innate immune response that engages in multiple inflammatory cascades as it becomes activated during tissue injury and remodeling. In this respect, complement proteins have been implicated in tissue and organ regeneration in both urodeles and mammals. Distinct complement-triggered pathways have been shown to modulate critical responses that promote tissue reprogramming, pattern formation, and regeneration across phylogenesis. This article will discuss the mechanistic insights underlying the crosstalk of complement with cytokine and growth factor signaling pathways that drive tissue regeneration and will provide a unified conceptual framework for considering complement modulation as a novel target for regenerative therapeutics. PMID:23684626

Mastellos, Dimitrios C.; DeAngelis, Robert A.; Lambris, John D.

2014-01-01

377

Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice. A preliminary report  

EPA Science Inventory

Arsenic (+3 oxidation state) methyltransferase (As3mt) catalyzes reactions which convert inorganic arsenic to methylated metabolites. This study determined whether the As3mt null genotype in the mouse modifies cytotoxic and proliferative effects seen in urinary bladders of wild t...

378

Thyroid hormone-responsive pituitary hyperplasia independent of somatostatin receptor 2.  

PubMed

Mice homozygous for the targeted disruption of the glycoprotein hormone alpha-subunit (alphaGsu) display hypertrophy and hyperplasia of the anterior pituitary thyrotropes. Thyrotrope hyperplasia results in tumors in aged alphaGsu(-/-) mice. These adenomatous pituitaries can grow independently as intrascapular transplants in hypothyroid mice, suggesting that they have progressed beyond simple hyperplasia. We used magnetic resonance imaging to follow the growth and regression of thyrotrope adenomatous hyperplasia in response to thyroid hormone treatment and discovered that the tumors retain thyroid hormone responsiveness. Somatostatin (SMST) and its diverse receptors have been implicated in cell proliferation and tumorigenesis. To test the involvement of SMST receptor 2 (SMSTR2) in pituitary tumor progression and thyroid hormone responsiveness in alphaGsu(-/-) mutants, we generated Smstr2(-/-), alphaGsu(-/-) mice. Smstr2(-/-), alphaGsu(-/-) mice develop hyperplasia of thyrotropes, similar to alphaGsu(-/-) mutants, demonstrating that SMSTR2 is dispensable for the development of pituitary adenomatous hyperplasia. Thyrotrope hyperplasia in Smstr2(-/-), alphaGsu(-/-) mice regresses in response to T4 treatment, suggesting that SMSTR2 is not required in the T4 feedback loop regulating TSH secretion. PMID:11731614

Brinkmeier, M L; Stahl, J H; Gordon, D F; Ross, B D; Sarapura, V D; Dowding, J M; Kendall, S K; Lloyd, R V; Ridgway, E C; Camper, S A

2001-12-01

379

[Bilateral nodular hyperplasia of the adrenal glands; diagnostic problems].  

PubMed

Bilateral adrenal nodular hyperplasia (BAND) is rarely presented as a cause of Cushing Syndrome. The pathogenicity of the disease is unknown and it does not present either symptoms or specific signs, furthermore, its steroid dynamic is atypical and the morphologic tests are not conclusive. The clinical stories of six BAND-diagnosed patients in our Department have been reviewed with the aim of unifying the criteria of the preoperative diagnosis with regard to treatment, comparing our results with literature's wider series. The results from both studies demonstrate an hypophyseal dependence together with some others showing a adrenal autonomy. Thus, our conclusions perpetuate the pathogenic question about BAND (whether is an adrenal primary disfunction or a secondary effect caused by hypophyseal ACTH hypersecretion?) and we point out the usefulness of radioisotopic gammagraphy and abdominal-TAC, since usually they show the bilaterality of the injury at adrenal level. PMID:2203116

Vaquero, P M; de la Morena, L H; Gamboa, R A; Pallardo, L F; Corchado, M S; San Martín, L; Cano, R L; Mejía, A

1990-04-01

380

Orbital extension of supraorbital angiolymphoid hyperplasia with eosinophilia.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare clinicopathologic entity that shares both clinical and histopathological features with Kimura disease. Although they were once considered as different stages of the same disease, they are now known to represent separate entities. ALHE is a condition that causes swellings in the head and neck region affecting muscular arteries and is benign in nature.1 Orbital involvement is unusual. Diagnosis of ALHE is frequently confused with malignant tumour until biopsy is done.4 We present here a young female with unilateral, painless and slowly progressive swelling on the inner and upper aspect of her left orbit, who was diagnosed as a case of ALHE with orbital involvement on the basis of CT scan and excisional biopsy. Regular follow up was performed and no evidence of recurrence was found. PMID:23390457

Bangal, Sv; Chitgopekar, Rp; Gupta, Ak; Karle, R

2011-01-01

381

Angiolymphoid hyperplasia with eosinophilia: a clinicopathologic study of 9 cases.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disease characterized by single or multiple angiomatous lesions typically located on the scalp and the face. We present a retrospective analysis of 9 cases of ALHE. The lesions appeared largely as multiple grouped papules or, in some cases, subcutaneous nodules, located mainly on the scalp, particularly around the ear. We also observed lesions in atypical locations, such as areas of the head other than the scalp, and the shoulder, neck, and forearm. At these sites the lesions had an atypical clinical appearance that made diagnosis difficult; this should be borne in mind in patients with single, well-delimited lesions with a vascular appearance and superficial ulceration or crusting. Surgery was the most common treatment in our series, and even though ALHE is considered a benign condition, recurrence was common. PMID:23845664

Guinovart, R M; Bassas-Vila, J; Morell, L; Ferrándiz, C

2014-03-01

382

Angiolymphoid hyperplasia with eosinophilia: atypical appearance in an older patient.  

PubMed

We describe a 76-year-old man presenting with a chronic, non-healing ulcer of six-year duration on his left zygomatic area. The skin biopsy specimen taken from the lesion, showed increased vascular proliferation, edematous endothelial cells in the dermal blood vessels and perivascular eosinophilic/lymphocytic infiltration. The routine and specific blood tests were unremarkable. On the basis of these features, the patient was diagnosed as having angiolymphoid hyperplasia with eosinophilia (ALHE). We present the case because of its rarity in older people, atypical clinical appearance; and stress the consideration of ALHE in the differential diagnosis of chronic non-healing superficial ulcers confined to face and neck. PMID:19882016

Karabudak, Ozlem; Taskapan, Oktay; Bozdogan, Onder; Dogan, Bilal

2008-01-01

383

Orbital extension of supraorbital angiolymphoid hyperplasia with eosinophilia  

PubMed Central

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare clinicopathologic entity that shares both clinical and histopathological features with Kimura disease. Although they were once considered as different stages of the same disease, they are now known to represent separate entities. ALHE is a condition that causes swellings in the head and neck region affecting muscular arteries and is benign in nature.1 Orbital involvement is unusual. Diagnosis of ALHE is frequently confused with malignant tumour until biopsy is done.4 We present here a young female with unilateral, painless and slowly progressive swelling on the inner and upper aspect of her left orbit, who was diagnosed as a case of ALHE with orbital involvement on the basis of CT scan and excisional biopsy. Regular follow up was performed and no evidence of recurrence was found. PMID:23390457

Bangal, SV; Gupta, AK; Karle, R

2011-01-01

384

ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA: ATYPICAL APPEAREANCE IN AN OLDER PATIENT  

PubMed Central

We describe a 76-year-old man presenting with a chronic, non-healing ulcer of six-year duration on his left zygomatic area. The skin biopsy specimen taken from the lesion, showed increased vascular proliferation, edematous endothelial cells in the dermal blood vessels and perivascular eosinophilic/lymphocytic infiltration. The routine and specific blood tests were unremarkable. On the basis of these features, the patient was diagnosed as having angiolymphoid hyperplasia with eosinophilia (ALHE). We present the case because of its rarity in older people, atypical clinical appearance; and stress the consideration of ALHE in the differential diagnosis of chronic non-healing superficial ulcers confined to face and neck. PMID:19882016

Karabudak, Ozlem; Taskapan, Oktay; Bozdogan, Onder; Dogan, Bilal

2008-01-01

385

Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) in the oral mucosa.  

PubMed

Angiolymphoid hyperplasia with an eosinophilia (ALHE) is a rare benign entity whose etiology and pathogenesis is under debate. Clinically, it is characterised by cutaneous papules or nodules on the head and neck. Literature reveals very few cases of this entity in the oral mucosa. Here, we report a case of ALHE in a 25 year-old woman, who presented with a painless, 5mm x 5mm, sub mucosal erythematous nodule on left angle of mouth at lower lip. Histological examination of lip biopsy specimens revealed an increase in small vessels. The vascular walls consist of prominent endothelial cells with a histiocytoid appearance, which protruded into the lumen. Many eosinophils and lymphocytes were also seen around the vessels. The diagnosis of ALHE was made from the above findings. PMID:22945722

Aggarwal, Anshul; Keluskar, Vaishali

2012-01-01

386

Angiolymphoid hyperplasia with eosinophilia arising from the facial artery.  

PubMed

We report on a rare case of angiolymphoid hyperplasia with eosinophilia (ALHE) arising from the facial artery, which was pre-operatively diagnosed as an aneurysm. ALHE is a rare lesion, the precise nature of which remains controversial: it is still unclear whether ALHE is a tumour or an inflammatory disease or whether it can be separated from Kimura's disease based on its pathological characteristics. ALHE rarely occurs in muscular arteries, and this is the first description of ALHE arising from the facial artery. Angiography vividly revealed the pathological structure of the lesion in this case, which prompted us to advocate angiography for diagnosing ALHE arising from muscular arteries. Complete dissection and cryotherapy proved to be effective treatment, although complete management of any therapeutic protocol should avoid recurrence of the lesion, whatever specific treatments are selected. PMID:12901818

Kimura, Yurika; Tsutsumi, Takeshi; Kuroishikawa, Yasushi; Kishimoto, Seiji

2003-07-01

387

Management of the Adult with Congenital Adrenal Hyperplasia  

PubMed Central

Congenital adrenal hyperplasia (CAH), most commonly due to 21-hydroxylase deficiency (21OHD), has been studied by pediatric endocrinologists for decades. Advances in the care of these patients have enabled many of these children to reach adulthood. In contrast to the course and management of the disease in childhood, little is known about CAH in adults. In many patients, the proclivity to salt-wasting crises decreases. Linear growth ceases, and reproductive function becomes an issue. Most importantly, management must minimize the potential for long-term consequences of conventional therapies. Here we review the existing literature regarding comorbidities of adults with 21OHD, goals of treatment, and approaches to therapy, with an emphasis on need for improved management strategies. PMID:20613954

Auchus, Richard J.

2010-01-01

388

Mandible condylar hyperplasia: a review of diagnosis and treatment protocol  

PubMed Central

Condylar hyperplasia (CH) is a bone disease characterized by the increased development of one mandibular condyle. It regularly presents as an active growth with facial asymmetry generally without pain. Statistically it affects more women in adolescence, although it does not discriminate by age or gender. Its best-known consequence is asymmetric facial deformity (AFD), which combined with alteration of the dental occlusion with unilateral crossbite or open bite. It is not known when CH begins and how long it lasts; diagnostic examinations are described and are efficient in some research about diagnosis. Protocol treatment is not well studie and depends on the criteria described in this paper. The aim of this research is to provide up-to-date information about the diagnosis of this disease and to analyze the treatment protocol, visualizing the CH and AFD presented. PMID:24179565

Olate, Sergio; Netto, Henrique Duque; Rodriguez-Chessa, Jaime; Alister, Juan Pablo; de Albergaria-Barbosa, Jose; de Moraes, Márcio

2013-01-01

389

Economic issues and the management of benign prostatic hyperplasia.  

PubMed

Enormous financial resources are expended worldwide on the treatment of the urologic complications and symptoms induced by benign prostatic hyperplasia (BPH). Even for its surgical management, where the best data exist, current international accounting of these expenditures remains very poorly documented. On February 8, 1994, the Department of Health and Human Services of the US government released clinical guidelines for the diagnosis and management of BPH. Imaging of the upper urinary tract as a routine diagnostic procedure is not recommended in these guidelines unless a comorbidity indicating its need exists. Diagnostic cystoscopy to assist in the decision of the need to treat is not recommended. Adherence to these two principles along with adherence to the strategies of management presented in the guidelines and discussed herein has the potential of achieving profound financial savings without impairing quality of care worldwide. PMID:7544513

Holtgrewe, H L

1995-09-01

390

Hydrocephalus due to diffuse villous hyperplasia of the choroid plexus.  

PubMed

An 8-month-old female presented with hydrocephalus caused by cerebrospinal fluid (CSF) overproduction due to bilateral choroid plexus enlargement, which was clinically diagnosed as diffuse villous hyperplasia of the choroid plexus, but differentiation from bilateral choroid plexus papilloma was difficult. She initially underwent ventriculoperitoneal shunt surgery, but developed marked retention of ascites. Therefore, the peritoneal end of the shunt was removed for external drainage, but excessive CSF (1,500 ml/day) was collected. Computed tomography and magnetic resonance imaging revealed marked symmetric enhancement of the choroid plexuses in the bilateral lateral ventricles. Thallium-201 chloride single-photon emission computed tomography showed pronounced uptake on both early and delayed images, and good washout. CSF examination revealed no abnormalities such as atypical cells, and a ventriculoatrial shunt was inserted, achieving good control of the hydrocephalus. PMID:21701109

Anei, Ryogo; Hayashi, Yoshimitsu; Hiroshima, Satoru; Mitsui, Nobuyuki; Orimoto, Ryosuke; Uemori, Genki; Saito, Masato; Sato, Masao; Wada, Hajime; Hododuka, Akira; Kamada, Kyousuke

2011-01-01

391

Splicing factor SRSF6 promotes hyperplasia of sensitized skin  

PubMed Central

Summary Many biological processes involve gene-expression regulation by alternative splicing. Here, we identify the splicing factor SRSF6 as a regulator of wound healing and tissue homeostasis in skin. We show that SRSF6 is a proto-oncogene that is frequently overexpressed in human skin cancer. Overexpressing it in transgenic mice induces hyperplasia of sensitized skin and promotes aberrant alternative splicing. We identify 139 target genes of SRSF6 in skin, and show that this SR protein binds to alternative exons of the extracellular-matrix protein tenascin C pre-mRNA, promoting the expression of isoforms characteristic of invasive and metastatic cancer in a cell-type-independent manner. SRSF6 overexpression additionally results in depletion of Lgr6+ stem cells, and excessive keratinocyte proliferation and response to injury. Furthermore, the effects of SRSF6 in wound healing assayed in vitro depend on the TNC isoforms. Thus, abnormal SR-protein expression can perturb tissue homeostasis. PMID:24440982

Jensen, Mads A.; Wilkinson, John E.; Krainer, Adrian R.

2014-01-01

392

AMR (Active Magnetic Regenerative) refrigeration for low temperature  

NASA Astrophysics Data System (ADS)

This paper reviews AMR (Active Magnetic Regenerative) refrigeration technology for low temperature applications that is a novel cooling method to expand the temperature span of magnetic refrigerator. The key component of the AMR system is a porous magnetic regenerator which allows a heat transfer medium (typically helium gas) to flow through it and therefore obviate intermittently operating an external heat switch. The AMR system alternatingly heats and cools the heat transfer medium by convection when the magneto-caloric effect is created under varying magnetic field. AMR may extend the temperature span for wider range than ADR (Adiabatic Demagnetization Refrigerator) at higher temperatures above 10 K because magneto-caloric effects are typically concentrated in a small temperature range in usual magnetic refrigerants. The regenerative concept theoretically enables each magnetic refrigerant to experience a pseudo-Carnot magnetic refrigeration cycle in a wide temperature span if it is properly designed, although adequate thermodynamic matching of strongly temperature-dependent MCE (magneto-caloric effect) of the regenerator material and the heat capacity of fluid flow is often tricky due to inherent characteristics of magnetic materials. This paper covers historical developments, fundamental concepts, key components, applications, and recent research trends of AMR refrigerators for liquid helium or liquid hydrogen temperatures.

Jeong, Sangkwon

2014-07-01

393

Assessing hematopoietic (stem-) cell behavior during regenerative pressure.  

PubMed

Hematopoiesis is a complex and strongly regulated process. In case of regenerative pressure, efficient recovery of blood cell counts is crucial for survival of an individual. We propose a quantitative mathematical model of white blood cell formation based on the following cell parameters: (1) proliferation rate, (2) self-renewal, and (3) cell death. Simulating this model we assess the change of these parameters under regenerative pressure. The proposed model allows to quantitatively describe the impact of these cell parameters on engraftment time after stem cell transplantation. Results indicate that enhanced self-renewal during the posttransplant period is crucial for efficient regeneration of blood cell counts while constant or reduced self-renewal leads to delayed recovery or graft failure. Increased cell death in the posttransplant period has a similar impact. In contrast, reduced proliferation or pre-homing cell death causes only mild delays in blood cell recovery which can be compensated sufficiently by increasing the dose of transplanted cells. PMID:25480650

Stiehl, Thomas; Ho, Anthony D; Marciniak-Czochra, Anna

2014-01-01

394

Macro and Microfluidic Flows for Skeletal Regenerative Medicine  

PubMed Central

Fluid flow has a great potential as a cell stimulatory tool for skeletal regenerative medicine, because fluid flow-induced bone cell mechanotransduction in vivo plays a critical role in maintaining healthy bone homeostasis. Applications of fluid flow for skeletal regenerative medicine are reviewed at macro and microscale. Macroflow in two dimensions (2D), in which flow velocity varies along the normal direction to the flow, has explored molecular mechanisms of bone forming cell mechanotransduction responsible for flow-regulated differentiation, mineralized matrix deposition, and stem cell osteogenesis. Though 2D flow set-ups are useful for mechanistic studies due to easiness in in situ and post-flow assays, engineering skeletal tissue constructs should involve three dimensional (3D) flows, e.g., flow through porous scaffolds. Skeletal tissue engineering using 3D flows has produced promising outcomes, but 3D flow conditions (e.g., shear stress vs. chemotransport) and scaffold characteristics should further be tailored. Ideally, data gained from 2D flows may be utilized to engineer improved 3D bone tissue constructs. Recent microfluidics approaches suggest a strong potential to mimic in vivo microscale interstitial flows in bone. Though there have been few microfluidics studies on bone cells, it was demonstrated that microfluidic platform can be used to conduct high throughput screening of bone cell mechanotransduction behavior under biomimicking flow conditions. PMID:24710552

Riehl, Brandon D.; Lim, Jung Yul

2012-01-01

395

Fuzzy stability analysis of regenerative chatter in milling  

NASA Astrophysics Data System (ADS)

During machining, unstable self-excited vibrations known as regenerative chatter can occur, causing excessive tool wear or failure, and a poor surface finish on the machined workpiece. Consequently it is desirable to predict, and hence avoid the onset of this instability. Regenerative chatter is a function of empirical cutting coefficients, and the structural dynamics of the machine-tool system. There can be significant uncertainties in the underlying parameters, so the predicted stability limits do not necessarily agree with those found in practice. In the present study, fuzzy arithmetic techniques are applied to the chatter stability problem. It is first shown that techniques based upon interval arithmetic are not suitable for this problem due to the issue of recursiveness. An implementation of fuzzy arithmetic is then developed based upon the work of Hanss and Klimke. The arithmetic is then applied to two techniques for predicting milling chatter stability: the classical approach of Altintas, and the time-finite element method of Mann. It is shown that for some cases careful programming can reduce the computational effort to acceptable levels. The problem of milling chatter uncertainty is then considered within the framework of Ben-Haim's information-gap theory. It is shown that the presented approach can be used to solve process design problems with robustness to the uncertain parameters. The fuzzy stability bounds are then compared to previously published data, to investigate how uncertainty propagation techniques can offer more insight into the accuracy of chatter predictions.

Sims, Neil D.; Manson, Graeme; Mann, Brian

2010-04-01

396

Gaussian-only regenerative stations cannot act as quantum repeaters  

NASA Astrophysics Data System (ADS)

Higher transmission loss diminishes the performance of optical communication—be it the rate at which classical or quantum data can be sent reliably, or the secure key generation rate of quantum key distribution (QKD). Loss compounds with distance—exponentially in an optical fiber, and inverse square with distance for a free-space channel. In order to boost classical communication rates over long distances, it is customary to introduce regenerative relays at intermediate points along the channel. It is therefore natural to speculate whether untended regenerative stations, such as phase-insensitive or phase-sensitive optical amplifiers, could serve as repeaters for long-distance QKD. The primary result of this paper rules out all bosonic Gaussian channels to be useful as QKD repeaters, which include phase-insensitive and phase-sensitive amplifiers as special cases, for any QKD protocol. We also delineate the conditions under which a Gaussian relay renders a lossy channel entanglement breaking, which in turn makes the channel useless for QKD.

Namiki, Ryo; Gittsovich, Oleg; Guha, Saikat; Lütkenhaus, Norbert

2014-12-01

397

Regeneratively cooled rocket engine for space storable propellants  

NASA Technical Reports Server (NTRS)

Analyses and experimental studies were performed with the OF2 (F2/O2)/B2H6 propellant combination over a range in operating conditions to determine suitability for a space storable pressure fed engine configuration for an extended flight space vehicle configuration. The regenerative cooling mode selected for the thrust chamber was explored in detail with the use of both the fuel and oxidizer as coolants in an advanced milled channel construction thrust chamber design operating at 100 psia chamber pressure and a nominal mixture ratio of 3.0 with a 60:1 area ratio nozzle. Benefits of the simultaneous cooling as related to gaseous injection of both fuel and oxidizer propellants were defined. Heat transfer rates, performance and combustor stability were developed for impinging element triplet injectors in uncooled copper calorimeter hardware with flow, pressure and temperature instrumentation. Evaluation of the capabilities of the B2H6 and OF2 during analytical studies and numerous tests with flow through electrically heated blocks provided design criteria for subsequent regenerative chamber design and fabrication.

Wagner, W. R.; Waldman, B. J.

1973-01-01

398

Johnson Space Center's regenerative life support systems test bed  

NASA Technical Reports Server (NTRS)

The Regenerative Life Support System (RLSS) Test Bed at NASA's Johnson Space Center is an atmospherically closed, controlled environment facility for the evaluation of regenerative life support systems using higher plants in conjunction with physicochemical life support systems. When completed, the facility will be comprised of two large scale plant growth chambers, each with approximately 10 m(exp 2) growing area. One of the two chambers, the Variable Pressure Growth Chamber (VPGC), will be capable of operating at lower atmospheric pressures to evaluate a range of environments that may be used in Lunar or Martian habitats; the other chamber, the Ambient Pressure Growth Chamber (APGC) will operate at ambient atmospheric pressure. The root zone in each chamber will be configurable for hydroponic or solid state media systems. Research will focus on: (1) in situ resource utilization for CELSS systems, in which simulated lunar soils will be used in selected crop growth studies; (2) integration of biological and physicochemical air and water revitalization systems; (3) effect of atmospheric pressure on system performance; and (4) monitoring and control strategies.

Henninger, Donald L.; Tri, Terry O.; Barta, Daniel J.; Stahl, Randal S.

1991-01-01

399

Could Gaussian regenerative stations act as quantum repeaters?  

E-print Network

Higher transmission loss diminishes the performance of optical communication|be it the rate at which classical or quantum data can be sent reliably, or the secure key generation rate of quantum key distribution (QKD). Loss compounds with distance|exponentially in an optical fiber, and inverse-square with distance for a free-space channel. In order to boost classical communication rates over long distances, it is customary to introduce regenerative relays at intermediate points along the channel. It is therefore natural to speculate whether untended regenerative stations, such as phase-insensitive or phase-sensitive optical amplifiers, could serve as repeaters for long-distance QKD. The primary result of this paper rules out all bosonic Gaussian channels to be useful as QKD repeaters, which include phase-insensitive and phase-sensitive amplifiers as special cases, for any QKD protocol. We also delineate the conditions under which a Gaussian relay renders a lossy channel entanglement breaking, which in turn makes the channel useless for QKD.

Ryo Namiki; Oleg Gittsovich; Saikat Guha; Norbert Lütkenhaus

2014-10-02

400

Johnson Space Center's Regenerative Life Support Systems Test Bed  

NASA Technical Reports Server (NTRS)

The Regenerative Life Support Systems (RLSS) Test Bed at NASA's Johnson Space Center is an atmospherically closed, controlled environment facility for human testing of regenerative life support systems using higher plants in conjunction with physicochemical life support systems. The facility supports NASA's Advanced Life Support (ALS) Program. The facility is comprised of two large scale plant growth chambers, each with approximately 11 m2 growing area. The root zone in each chamber is configurable for hydroponic or solid media plant culture systems. One of the two chambers, the Variable Pressure Growth Chamber (VPGC), is capable of operating at lower atmospheric pressures to evaluate a range of environments that may be used in a planetary surface habitat; the other chamber, the Ambient Pressure Growth Chamber (APGC) operates at ambient atmospheric pressure. The air lock of the VPGC is currently being outfitted for short duration (1 to 15 day) human habitation at ambient pressures. Testing with and without human subjects will focus on 1) integration of biological and physicochemical air and water revitalization systems; 2) effect of atmospheric pressure on system performance; 3) planetary resource utilization for ALS systems, in which solid substrates (simulated planetary soils or manufactured soils) are used in selected crop growth studies; 4) environmental microbiology and toxicology; 5) monitoring and control strategies; and 6) plant growth systems design. Included are descriptions of the overall design of the test facility, including discussions of the atmospheric conditioning, thermal control, lighting, and nutrient delivery systems.

Barta, D. J.; Henninger, D. L.

1996-01-01

401

Therapeutic Potential of Mesenchymal Stem Cells in Regenerative Medicine  

PubMed Central

Mesenchymal stem cells (MSCs) are stromal cells that have the ability to self-renew and also exhibit multilineage differentiation into both mesenchymal and nonmesenchymal lineages. The intrinsic properties of these cells make them an attractive candidate for clinical applications. MSCs are of keen interest because they can be isolated from a small aspirate of bone marrow or adipose tissues and can be easily expanded in vitro. Moreover, their ability to modulate immune responses makes them an even more attractive candidate for regenerative medicine as allogeneic transplant of these cells is feasible without a substantial risk of immune rejection. MSCs secrete various immunomodulatory molecules which provide a regenerative microenvironment for a variety of injured tissues or organ to limit the damage and to increase self-regulated tissue regeneration. Autologous/allogeneic MSCs delivered via the bloodstream augment the titers of MSCs that are drawn to sites of tissue injury and can accelerate the tissue repair process. MSCs are currently being tested for their potential use in cell and gene therapy for a number of human debilitating diseases and genetic disorders. This paper summarizes the current clinical and nonclinical data for the use of MSCs in tissue repair and potential therapeutic role in various diseases. PMID:23577036

Patel, Devang M.; Shah, Jainy; Srivastava, Anand S.

2013-01-01

402

Tissue engineering and regenerative medicine –where do we stand?  

PubMed Central

Abstract Tissue Engineering (TE) in the context of Regenerative Medicine (RM) has been hailed for many years as one of the most important topics in medicine in the twenty-first century. While the first clinically relevant TE efforts were mainly concerned with the generation of bioengineered skin substitutes, subsequently TE applications have been continuously extended to a wide variety of tissues and organs. The advent of either embryonic or mesenchymal adult stem-cell technology has fostered many of the efforts to combine this promising tool with TE approaches and has merged the field into the term Regenerative Medicine. As a typical example in translational medicine, the discovery of a new type of cells called Telocytes that have been described in many organs and have been detected by electron microscopy opens another gate to RM. Besides cell-therapy strategies, the application of gene therapy combined with TE has been investigated to generate tissues and organs. The vascularization of constructs plays a crucial role besides the matrix and cell substitutes. Therefore, novel in vivo models of vascularization have evolved allowing axial vascularization with subsequent transplantation of constructs. This article is intended to give an overview over some of the most recent developments and possible applications in RM through the perspective of TE achievements and cellular research. The synthesis of TE with innovative methods of molecular biology and stem-cell technology appears to be very promising. PMID:22436120

Horch, Raymund E; Kneser, Ulrich; Polykandriotis, Elias; Schmidt, Volker J; Sun, Jiaming; Arkudas, Andreas

2012-01-01

403

Regeneratively Cooled Liquid Oxygen/Methane Technology Development  

NASA Technical Reports Server (NTRS)

The National Aeronautics & Space Administration (NASA) has identified Liquid Oxygen (LOX)/Liquid Methane (LCH4) as a potential propellant combination for future space vehicles based upon exploration studies. The technology is estimated to have higher performance and lower overall systems mass compared to existing hypergolic propulsion systems. NASA-Marshall Space Flight Center (MSFC) in concert with industry partner Pratt & Whitney Rocketdyne (PWR) utilized a Space Act Agreement to test an oxygen/methane engine system in the Summer of 2010. PWR provided a 5,500 lbf (24,465 N) LOX/LCH4 regenerative cycle engine to demonstrate advanced thrust chamber assembly hardware and to evaluate the performance characteristics of the system. The chamber designs offered alternatives to traditional regenerative engine designs with improvements in cost and/or performance. MSFC provided the test stand, consumables and test personnel. The hot fire testing explored the effective cooling of one of the thrust chamber designs along with determining the combustion efficiency with variations of pressure and mixture ratio. The paper will summarize the status of these efforts.

Robinson, Joel W.; Greene, Christopher B.; Stout, Jeffrey

2012-01-01

404

Unitized Regenerative Fuel Cell System Gas Storage-Radiator Development  

NASA Technical Reports Server (NTRS)

High-energy-density regenerative fuel cell systems that are used for energy storage require novel approaches to integrating components in order to preserve mass and volume. A lightweight unitized regenerative fuel cell (URFC) energy storage system concept is being developed at the NASA Glenn Research Center. This URFC system minimizes mass by using the surface area of the hydrogen and oxygen storage tanks as radiating heat surfaces for overall thermal control of the system. The waste heat generated by the URFC stack during charging and discharging is transferred from the cell stack to the surface of each tank by loop heat pipes, which are coiled around each tank and covered with a thin layer of thermally conductive carbon composite. The thin layer of carbon composite acts as a fin structure that spreads the heat away from the heat pipe and across the entire tank surface. Two different-sized commercial-grade composite tanks were constructed with integral heat pipes and tested in a thermal vacuum chamber to examine the feasibility of using the storage tanks as system radiators. The storage tank-radiators were subjected to different steady-state heat loads and varying heat load profiles. The surface emissivity and specific heat capacity of each tank were calculated. In the future, the results will be incorporated into a model that simulates the performance of similar radiators using lightweight, spacerated carbon composite tanks.

Burke, Kenneth A.; Jakupta, Ian

2005-01-01

405

High Energy Density Regenerative Fuel Cell Systems for Terrestrial Applications  

NASA Technical Reports Server (NTRS)

Regenerative Fuel Cell System (RFCS) technology for energy storage has been a NASA power system concept for many years. Compared to battery-based energy storage systems, RFCS has received relatively little attention or resources for development because the energy density and electrical efficiency were not sufficiently attractive relative to advanced battery systems. Even today, RFCS remains at a very low technology readiness level (TRL of about 2 indicating feasibility has been demonstrated). Commercial development of the Proton Exchange Membrane (PEM) fuel cells for automobiles and other terrestrial applications and improvements in lightweight pressure vessel design to reduce weight and improve performance make possible a high energy density RFCS energy storage system. The results from this study of a lightweight RFCS energy storage system for a remotely piloted, solar-powered, high altitude aircraft indicate an energy density up to 790 w-h/kg with electrical efficiency of 53.4% is attainable. Such an energy storage system would allow a solar-powered aircraft to carry hundreds of kilograms of payload and remain in flight indefinitely for use in atmospheric research, earth observation, resource mapping. and telecommunications. Future developments in the areas of hydrogen and oxygen storage, pressure vessel design, higher temperature and higher- pressure fuel cell operation, unitized regenerative fuel cells, and commercial development of fuel cell technology will improve both the energy density and electrical efficiency of the RFCS.

Burke, Kenneth A.

1999-01-01

406

Clinical concepts for regenerative therapy in intrabony defects.  

PubMed

Evidence indicates that periodontal regeneration is an efficacious and predictable procedure for the treatment of isolated and multiple intrabony defects. Meta-analyses from systematic reviews indicate an added benefit, in terms of clinical attachment level gain, when demineralized freeze-dried bone allograft, barrier membranes and active biologic products/compounds are applied in addition to open flap debridement. On the other hand, a consistent amount of variability of the outcomes is evident among different studies and within the experimental population of each study. This variability is explained, at least in part, by different patient and defect characteristics. Patient-related factors include smoking habit, compliance with home oral hygiene and residual inflammation after cause-related therapy. Defect-associated factors include defect depth and radiographic angle, the number of residual bony walls, pocket depth and the degree of hypermobility. In addition, surgical-related variables, such as surgical skill, clinical experience and knowledge, and application of the different regenerative materials, have a significant impact on clinical outcomes. This paper presents a strategy to optimize the clinical outcomes of periodontal regeneration. The surgical design of the flap, the use of different regenerative materials and the application of appropriate passive sutures are discussed in this review along with the scientific foundations. PMID:25867990

Cortellini, Pierpaolo; Tonetti, Maurizio S

2015-06-01

407

Renal stem cell reprogramming: Prospects in regenerative medicine  

PubMed Central

Stem cell therapy is a promising future enterprise for renal replacement in patients with acute and chronic kidney disease, conditions which affect millions worldwide and currently require patients to undergo lifelong medical treatments through dialysis and/or organ transplant. Reprogramming differentiated renal cells harvested from the patient back into a pluripotent state would decrease the risk of tissue rejection and provide a virtually unlimited supply of cells for regenerative medicine treatments, making it an exciting area of current research in nephrology. Among the major hurdles that need to be overcome before stem cell therapy for the kidney can be applied in a clinical setting are ensuring the fidelity and relative safety of the reprogrammed cells, as well as achieving feasible efficiency in the reprogramming processes that are utilized. Further, improved knowledge about the genetic control of renal lineage development is vital to identifying predictable and efficient reprogramming approaches, such as the expression of key modulators or the regulation of gene activity through small molecule mimetics. Here, we discuss several recent advances in induced pluripotent stem cell technologies. We also explore strategies that have been successful in renal progenitor generation, and explore what these methods might mean for the development of cell-based regenerative therapies for kidney disease. PMID:25258667

Morales, Elvin E; Wingert, Rebecca A

2014-01-01

408

Automatic selection of spindle speed for suppression of regenerative chatter in turning  

Microsoft Academic Search

The paper presents a new spindle speed regulation method to avoid regenerative chatter in turning operations. It is not necessary to analyse complex cutting dynamics to search for stable spindle speeds to eliminate regenerative chatter. The metal removal rate is also greatly improved by using this method. The stability lobe diagram for the stability limit of chip width and chatter

Y. S. Tarng; Y. W. Hseih; T. C. Li

1996-01-01

409

Regenerative heat transfer lowers compressor performance. [Heat losses in natural gas compressor systems affect performance  

Microsoft Academic Search

Regenerative heat in gas compressors diminishes performance, according to recent experiments. The results emphasize the importance of understanding and modeling the process to maximize operating efficiency. This paper presents results of experimental measurements done to determine regenerative heat transfer' contribution to suction gas heating and to compare its effect with earlier empirical models. These results form part of an ongoing

Prasad

1993-01-01

410

Dynamic response of a rotating ball screw subject to a moving regenerative force in grinding  

Microsoft Academic Search

This paper investigates the dynamic response of a rotating ball screw subjected to a moving regenerative force. The rotating ball screw is modeled as a rotating Timoshenko shaft with simply supports. The moving regenerative force describes the nonlinear interactions including the effects of wheel wear, time-delay, and the possibility of contact loss between the grinding wheel head and screw. The

T. N. Shiau; K. H. Huang; F. C. Wang; K. H. Chen; C. P. Kuo

2010-01-01

411

[Enzyme inhibition in the drug therapy of benign prostatic hyperplasia].  

PubMed

Enzyme inhibition belongs to common mechanisms of drug action and enzymes of hormone metabolism belong to targets in the treatment of benign prostatic hyperplasia. Transformation of testosterone to 5 alpha-dihydrotestosterone is catalyzed by cholestenone-5 alpha-reductase (EC 1.3.1.22, 5 alpha-reductase). Different effects of dihydrotestosterone and testosterone represent a rational basis for pharmacotherapy by 5 alpha-reductase inhibition. The enzyme is active in the prostate and other organs and tissues, with different distribution of at least two 5 alpha-reductase isoenzymes. Beside this, progesterone-5 alpha-reductase (EC 1.3.1.30) as another enzyme with 5 alpha-reductase activity is present in human tissues including the prostate. The existence of several 5 alpha-reductase activities gives bright possibilities of 5 alpha-reductase inhibition. Basic 5 alpha-reductase inhibitors are synthetic steroid (e.g. finasteride--Proscar). Various mechanisms of their effect (classical reversible competitive inhibition, mechanism-based "suicide" inhibitors, tightly bound irreversible inhibitors...) represent different pharmacokinetic patterns, too. Non-steroidal 5 alpha-reductase inhibitors (e.g. polyunsaturated fatty acids) are effective components of several phytopharmaceuticals. They receive attention due to their complexity and low hazards. Extracts of Serenoa repens seeds (Permixon, Capistan in the Czech Republic), of Pygeum africanum, of Urtica radicis roots (Urtica, Urtiron) or catequine structures from the green tea belong to this group. Beside androgens, participation of estrogens in the origin and development of benign prostatic hyperplasia is probable. Inhibition of the "aromatase" complex, which catalyzes transformation of androgens to estrogens, may contribute to the complexity of phytotherapeutic effects. PMID:12515038

Drsata, J

2002-10-11

412

Engineering model system study for a regenerative fuel cell: Study report  

NASA Technical Reports Server (NTRS)

Key design issues of the regenerative fuel cell system concept were studied and a design definition of an alkaline electrolyte based engineering model system or low Earth orbit missions was completed. Definition of key design issues for a regenerative fuel cell system include gaseous reactant storage, shared heat exchangers and high pressure pumps. A power flow diagram for the 75 kW initial space station and the impact of different regenerative fuel cell modular sizes on the total 5 year to orbit weight and volume are determined. System characteristics, an isometric drawing, component sizes and mass and energy balances are determined for the 10 kW engineering model system. An open loop regenerative fuel cell concept is considered for integration of the energy storage system with the life support system of the space station. Technical problems and their solutions, pacing technologies and required developments and demonstrations for the regenerative fuel cell system are defined.

Chang, B. J.; Schubert, F. H.; Kovach, A. J.; Wynveen, R. A.

1984-01-01

413

Postdoctoral Positions inStem (http://instem.res.in), a new institute for Stem Cell Biology and Regenerative  

E-print Network

and Regenerative Medicine collaborates and is located at the National Centre for Biological Sciences (NCBS, www, reprogramming and regenerative medicine. This Stem Cell Biology Laboratory is led by Kouichi Hasegawa who has candidates who are interested in a career in regenerative biology. Current projects include the study

Udgaonkar, Jayant B.

414

Nanotechnology-based approaches for regenerative medicine and biosensing  

NASA Astrophysics Data System (ADS)

The recent emergence of nanotechnology has set high expectations in many fields of science, especially in biology and medicine. Nanotechnology-based approaches are expected to solve key questions in the emerging field of regenerative medicine. Regenerative medicine essentially deals with regeneration of cells, ultimately leading to the formation of tissues and organs. For this purpose, stem cells, embryonic stem cells or adult stem cells, are thought to be ideal resources. However, many challenges need to be addressed before the full therapeutic potential of stem cells can be harnessed. Controlling the differentiation of stem cells into cells of a specific lineage is extremely vital and challenging. Addressing this challenge, in this work, novel nanotechnology-based approaches for controlling the differentiation of neural stem cells (NSCs) into neurons has been presented. Regeneration of damaged neurons, due to traumatic injuries or degenerative diseases, is extremely challenging. For this purpose, NSCs can be used as resources that can differentiate into neurons, thus having great potential in solving needs of many patients suffering from such conditions. For controlling the differentiation of stem cells, soluble cues (comprising of small molecules and biomolecules) and insoluble cues (cell-cell interactions and cell-microenvironment interactions) play a very important role. The delivery of soluble cues, such as genetic material, into stem cells is extremely challenging. The initial part of this work presents the use of nanomaterials for efficiently delivering soluble cues such as small molecules and small interfering RNA (siRNA) into NSCs for controlling their differentiation into neurons. However, for regenerative purposes, it is preferred that least amounts of the delivery vehicle be used. Thus, the following part of the thesis presents the development and applications of nanotechnology-based approaches for enhancing the differentiation of NSCs into neurons using insoluble cues. The cellular microenvironment, consisting for the extracellular matrix (ECM) was modified by the use of nanostructures, to deliver siRNA into NSCs to enhance neuronal differentiation. Nanotopography-mediated reverse uptake of only the siRNA molecules from the ECM was achieved by the NSCs. NSC differentiation was also controlled by the use of protein micropatterns, wherein the pattern geometry and size defined the fate of the NSCs. Lastly, graphene, in combination with nanoparticles was used as component of the ECM to not only enhance the differentiation of NSCs into neurons, but also align the axons of the differentiated NSCs, having significant implications for its use in regenerating injured spinal cords. The final portion of the thesis presents the applications of nanotechnology for developing highly sensitive and selective biosensors, for detecting biomarkers implicated in various diseases such as cancer and acute pancreatitis.

Solanki, Aniruddh P.

415

Should We Investigate Prostatic Inflammation for the Management of Benign Prostatic Hyperplasia?  

Microsoft Academic Search

ContextAlthough benign prostatic hyperplasia (BPH) is the most frequent disease in elderly men, only a few predictive factors have been identified. Recently, prostatic inflammation has emerged as one of them.

Grégoire Robert; Aurélien Descazeaud; Yves Allory; Francis Vacherot; Alexandre de la Taille

2009-01-01

416

Calcium channel blocker-induced gingival hyperplasia: case report and review of this iatrogenic disease.  

PubMed

Gingival hyperplasia is a common disorder associated with phenytoin and cyclosporine therapy. However, induction of this condition by calcium channel blockers is less well known. Inflammation of the gingival tissue from bacterial plaque and the subsequent development of gingival crevicular fluid may allow sequestration of the calcium channel blocker, thus predisposing the tissue to a localized toxic effect and the development of gingival hyperplasia. Calcium channel blockers have cellular effects similar to those of phenytoin and cyclosporine, including the production of a localized folic acid deficiency. All of the available calcium channel blockers have been reported to cause gingival hyperplasia. Treatment options include meticulous plaque control, and in severe cases, gingivectomy. Gingival hyperplasia can be prevented with meticulous plaque control or avoidance of the offending medication. PMID:7964547

Lawrence, D B; Weart, C W; Laro, J J; Neville, B W

1994-11-01

417

Long-term 6-year experience with finasteride in patients with benign prostatic hyperplasia  

Microsoft Academic Search

ObjectivesTo summarize the 6-year clinical trial data with finasteride. Benign prostatic hyperplasia is a chronic and progressive disease and therefore assessment of long-term safety and efficacy is important.

Franklin C Lowe; John D McConnell; Perry B Hudson; Nicholas A Romas; Rex Boake; Michael Lieber; Mostafa Elhilali; Jack Geller; Juliane Imperto-McGinely; Gerald L Andriole; Reginald C Bruskewitz; Patrick C Walsh; Georg Bartsch; John N Nacey; Sukrut Shah; Frances Pappas; Amy Ko; Thomas Cook; Elizabeth Stoner; Joanne Waldstreicher

2003-01-01

418

False-positive 123I-MIBG scintigraphy due to multiple focal nodular hyperplasia.  

PubMed

123I-MIBG accumulation in focal nodular hyperplasia was demonstrated. A 16-year-old girl who received radiotherapy for neuroblastoma at the age of 5 presented for abdominal pain. Three MIBG-avid tumors within the liver were proven to be focal nodular hyperplasias through biopsy. Previous neuroblastoma was transformed to non-MIBG-avid ganglioneuroma. MIBG accumulation does not necessarily indicate the presence of neuroendocrine tumor. PMID:24152616

Kulatunge, Chanika R; Son, Hongju

2013-12-01

419

Paclitaxel Stent Coating Inhibits Neointimal Hyperplasia at 4 Weeks in a Porcine Model of Coronary Restenosis  

Microsoft Academic Search

Background—Despite limiting elastic recoil and late vascular remodeling after angioplasty, coronary stents remain vulnerable to restenosis, caused primarily by neointimal hyperplasia. Paclitaxel, a microtubule-stabilizing drug, has been shown to inhibit vascular smooth muscle cell migration and proliferation contributing to neointimal hyperplasia. We tested whether paclitaxel-coated coronary stents are effective at preventing neointimal proliferation in a porcine model of restenosis. Methods

Alan W. Heldman; Linda Cheng; G. Mark Jenkins; Phillip F. Heller; Dong-Woon Kim; Melvin Ware; Cynthia Nater; Ralph H. Hruban; Banafsheh Rezai; Benjamin S. Abella; Katherine E. Bunge; James L. Kinsella; Steven J. Sollott; Edward G. Lakatta; Jeffrey A. Brinker; William L. Hunter; Jeffrey P. Froehlich

2010-01-01

420

Predictive diagnosis of endometrial hyperplasia and personalized therapeutic strategy in women of fertile age  

PubMed Central

Introduction Endometrial hyperplasia has a high risk for malignant transformation and relapses; existing mini-invasive treatments may lead to irrevocable endometrium destruction. The aims were to analyze receptor systems in endometrial hyperplasia, to evaluate the capabilities of ultrasonography, sonoelastography for diagnosis and treatment control, and to develop treatment algorithm. Materials and methods We included 313 women (20–45 years), assessed into the following: group 1 (n?=?112) with glandular cystic hyperplasia, group 2 (n?=?98) endometrial polyps, and group 3 (n?=?103) atypical hyperplasia; and 82 controls who have undergone hysteroscopy before in vitro fertilization in tubal origin infertility were also included. Patients underwent clinical examination, transvaginal ultrasound, immunohistochemical study, and hormonal therapy/hysteroresectoscopy. Results In patients with glandular hyperplasia, we registered increase of endometrium estrogen receptors (75.6% in the epithelium and 30.9% in the stroma; in controls, 43.3% and 29.6%, respectively); in polyps, there was a significant estrogen receptor increase in the stroma (48.2% vs 29.6% in controls), and in atypical hyperplasia, progesterone receptors significantly increased in the stroma. Ki-67 increased (40% to 50%) in the epithelium without changes in the stroma. Ultrasound has a sensitivity of 96% and a specificity of 85% for early detection of endometrial pathology and prediction outcome of intervention, and sonoelastography has a sensitivity of 91% and a specificity of 83% for polyp diagnosis. Personalized treatment was effective in 88.8%, relapse was diagnosed in 11.2% after 6 months, and conservative treatment of atypical hyperplasia was effective in 45%: in 25.8%, ablative hysteroresectoscopy was performed, while in 22.6% with comorbidities, hystero/oophorectomies were performed. Conclusions The evaluation of receptor status with ultrasound data in patients with endometrial hyperplasia allows for a clear definition of the treatment policy, avoidance of relapse, treatment optimization, and observation of such patients. PMID:24314145

2013-01-01

421

Focal nodular hyperplasia: typical and atypical MRI findings with emphasis on the use of contrast media.  

PubMed

Focal nodular hyperplasia is a benign hypervascular hepatic tumour, frequently detected in asymptomatic patients undergoing imaging studies for unrelated reasons. Magnetic resonance imaging (MRI) generally allows a confident differential diagnosis with other hypervascular liver lesions, either benign or malignant. In addition, due to the recent development of hepatospecific MRI contrast agents, MRI concomitantly enables functional and morphological information to be obtained, thus providing important clues for the detection and characterization of focal nodular hyperplasia lesions. PMID:18374723

Marin, D; Brancatelli, G; Federle, M P; Lagalla, R; Catalano, C; Passariello, R; Midiri, M; Vilgrain, V

2008-05-01

422

Radioactive stents delay but do not prevent in-stent neointimal hyperplasia  

Microsoft Academic Search

BACKGROUND: Restenosis after conventional stenting is almost exclusively caused by neointimal hyperplasia. Beta-particle-emitting radioactive stents decrease in-stent neointimal hyperplasia at 6-month follow-up. The purpose of this study was to evaluate the 1-year outcome of (32)P radioactive stents with an initial activity of 6 to 12 microCi using serial quantitative coronary angiography and volumetric ECG-gated 3D intravascular ultrasound (IVUS). METHODS AND

I. Patrick Kay; Alexander J. Wardeh; Ken Kozuma; A. H. M. Knook; A. Thury; P. W. J. C. Serruys; D. P. Foley; P. C. Levendag; Giessen van der W. J; G. Sianos

2001-01-01

423

[Primary hyperaldosteronism by unilateral adrenal hyperplasia: a report of two cases].  

PubMed

Primary aldosteronism (PA) is actually the main cause of adrenal-endocrine hypertension. This syndrome is characterized by hypertension, hypokalemia, suppressed plasma renin activity, and increased aldosterone excretion. The most common causes of this syndrome are bilateral idiopathic hyperaldosteronism and aldosterone producing adenoma (Conn's syndrome) and less frequently unilateral adrenal hyperplasia, adrenal carcinoma, or familial hyperaldosteronism. Unilateral adrenal hyperplasia (UAP) constitutes 2% of the causes of PA. We present the case of two patients with UAP. PMID:24276190

Ferreira-Hermosillo, Aldo; Hernández-Martínez, Alex Francisco; Hernández-García, Irma; Molina-Ayala, Mario

2013-01-01

424

Regenerative braking device with rotationally mounted energy storage means  

DOEpatents

A regenerative braking device for an automotive vehicle includes an energy storage assembly (12) having a plurality of rubber rollers (26, 28) mounted for rotation between an input shaft (30) and an output shaft (32), clutches (50, 56) and brakes (52, 58) associated with each shaft, and a continuously variable transmission (22) connectable to a vehicle drivetrain and to the input and output shafts by the respective clutches. In a second embodiment the clutches and brakes are dispensed with and the variable ratio transmission is connected directly across the input and output shafts. In both embodiments the rubber rollers are torsionally stressed to accumulate energy from the vehicle when the input shaft rotates faster or relative to the output shaft and are torsionally relaxed to deliver energy to the vehicle when the output shaft rotates faster or relative to the input shaft.

Hoppie, Lyle O. (Birmingham, MI)

1982-03-16

425

Free-piston regenerative hot gas hydraulic engine  

NASA Technical Reports Server (NTRS)

A displacer piston which is driven pneumatically by a high-pressure or low-pressure gas is included in a free-piston regenerative hydraulic engine. Actuation of the displacer piston circulates the working fluid through a heater, a regenerator and a cooler. The present invention includes an inertial mass such as a piston or a hydraulic fluid column to effectively store and supply energy during portions of the cycle. Power is transmitted from the working fluid to a hydraulic fluid across a diaphragm or lightweight piston to achieve a hydraulic power out-put. The displacer piston of the present invention may be driven pneumatically, hydraulically or electromagnetically. In addition, the displacer piston and the inertial mass of the present invention may be positioned on the same side of the diaphragm member or may be separated by the diaphragm member.

Beremand, D. G. (inventor)

1980-01-01

426

Alkaline regenerative fuel cell systems for energy storage  

NASA Technical Reports Server (NTRS)

A description is presented of the results of a preliminary design study of a regenerative fuel cell energy storage system for application to future low-earth orbit space missions. The high energy density storage system is based on state-of-the-art alkaline electrolyte cell technology and incorporates dedicated fuel cell and electrolysis cell modules. In addition to providing energy storage, the system can provide hydrogen and oxygen for attitude control of the satellite and for life support. During the daylight portion of the orbit the electrolysis module uses power provided by the solar array to generate H2 and O2 from the product water produced by the fuel cell module. The fuel cell module supplies electrical power during the dark period of the orbit.

Schubert, F. H.; Reid, M. A.; Martin, R. E.

1981-01-01

427

[Ethical, legal and social issues in regenerative medicine].  

PubMed

Regenerative medicine, currently on the stage of research, implies important ethical issues. Current main stream is the embryonic stem cell research which implies destruction of embryo in order to derive ES cells. Is such a use (destruction) of a human embryo, which is called a "germ of human life" in Japanese Society, ethically permitted or not? If yes, in which conditions? Expected clinical use of ES cells and differentiated cells thereof requires therapeutic cloning, on which arises also the ethical permissibility. Such heavy ethical obstacle leads researchers to the utilization of adult stem cells. Recent appearance of iPS cell (induced pluri-potential stem cell) does not escape from ethical issues, although the destruction of embryo is avoided. PMID:18464522

Ida, Ryuichi

2008-05-01

428

Imaginal discs: Renaissance of a model for regenerative biology.  

PubMed

Many animals display a capacity to regenerate tissues or even a complete body. One of the main goals of regenerative biology is to identify the genes and genetic networks necessary for this process. Drosophila offers an ideal model system for such studies. The wide range of genetic and genomic approaches available for use in flies has helped in initiating the deciphering of the mechanisms underlying regeneration, and the results may be applicable to other organisms, including mammals. Moreover, most models of regeneration require experimental manipulation, whereas in Drosophila discrete domains can be ablated by genetically induced methods. Here, we present a summary of current research into imaginal disc regeneration and discuss the power of this tissue as a tool for understanding the genetics of regeneration. PMID:20127699

Bergantiños, Cora; Vilana, Xavier; Corominas, Montserrat; Serras, Florenci

2010-03-01

429

Current overview on dental stem cells applications in regenerative dentistry.  

PubMed

Teeth are the most natural, noninvasive source of stem cells. Dental stem cells, which are easy, convenient, and affordable to collect, hold promise for a range of very potential therapeutic applications. We have reviewed the ever-growing literature on dental stem cells archived in Medline using the following key words: Regenerative dentistry, dental stem cells, dental stem cells banking, and stem cells from human exfoliated deciduous teeth. Relevant articles covering topics related to dental stem cells were shortlisted and the facts are compiled. The objective of this review article is to discuss the history of stem cells, different stem cells relevant for dentistry, their isolation approaches, collection, and preservation of dental stem cells along with the current status of dental and medical applications. PMID:25810631

Bansal, Ramta; Jain, Aditya

2015-01-01

430

Microbiological characterization of a regenerative life support system  

NASA Technical Reports Server (NTRS)

A Variable Pressure Plant Growth Chamber (VPGC), at the Johnson Space Center's (JSC) ground based Regenerative Life Support Systems (RLSS) test bed, was used to produce crops of soil-grown lettuce. The crops and chamber were analyzed for microbiological diversity during lettuce growth and after harvest. Bacterial counts for the rhizosphere, spent nutrient medium, heat exchanger condensate, and atmosphere were approximately 10(exp 11) Colony Forming Units (CFU)/g, 10(exp 5) CFU/ml, 10(exp 5)CFU/ml, and 600 CFU/m sq, repectively. Pseudomonas was the predominant bacterial genus. Numbers of fungi were about 10(exp 5) CFU/g in the rhizosphere, 4-200 CFU/ml in the spent nutient medium, 110 CFU/ml in the heat exchanger condensate, and 3 CFU/cu m in the atmosphere. Fusarium and Trichoderma were the predominant fungal genera.

Koenig, D. W.; Bruce, R. J.; Mishra, S. K.; Barta, D. J.; Pierson, D. L.

1994-01-01

431

Microbiological characterization of a regenerative life support system  

NASA Astrophysics Data System (ADS)

A Variable Pressure Plant Growth Chamber (VPGC), at the Johnson Space Center's (JSC) ground-based Regenerative Life Support Systems (RLSS) test bed, was used to produce crops of soil-grown lettuce. The crops and chamber were analyzed for microbiological diversity during lettuce growth and after harvest. Bacterial counts for the rhizosphere, spent nutrient medium, heat exchanger condensate, and atmosphere were approximately 1011 Colony Forming Units (CFU) g-1, 105 CFU ml-1, 105 CFU ml-1, and 600 CFU m-3, respectively. Pseudomonas was the predominant bacterial genus. Numbers of fungi were about 105 CFU g-1 in the rhizosphere, 4-200 CFU ml-1 in thespent nutrient medium, 110 CFU ml-1 in the heat exchanger condensate, and 3 CFU m-3 in the atmosphere. Fusarium and Trichoderma were the predominant fungal genera.

Koenig, D. W.; Bruce, R. J.; Mishra, S. K.; Barta, D. J.; Pierson, D. L.

1994-11-01

432

Urine - A waste or the future of regenerative medicine?  

PubMed

In recent years, urine has emerged as a source of urine cells. Two different types of cells can be isolated from urine: urine derived stem cells (USCs) and renal tubular cells called urine cells (UCs). USCs have great differentiation properties and can be potentially used in genitourinary tract regeneration. Within this paper, we attempt to demonstrate that such as easily accessible source of cells, collected during completely non-invasive procedures, can be better utilized. Cells derived from urine can be isolated, stored, and used for the creation of urine stem cell banks. In the future, urine holds great potential to become a main source of cells for tissue engineering and regenerative medicine. PMID:25649852

Kloskowski, T; Nowacki, M; Pokrywczy?ska, M; Drewa, T

2015-04-01

433

Self-assembling peptide scaffolds for regenerative medicine  

PubMed Central

Biomaterials made from self-assembling, short peptides and peptide derivatives have great potential to generate powerful new therapies in regenerative medicine. The high signaling capacity and therapeutic efficacy of peptidic scaffolds has been established in several animal models, and the development of more complex, hierarchical structures based on peptide materials is underway. This highlight discusses several classes of self-assembling peptide-based materials, including peptide amphiphiles, Fmoc-peptides, self-complementary ionic peptides, hairpin peptides, and others. The self-assembly designs, bioactive signalling strategies, and cell signalling capabilities of these bioactive materials are reported. The future challenges of the field are also discussed, including short-term goals such as integration with biopolymers and traditional implants, and long term goals, such as immune system programming, subcellular targeting, and the development of highly integrated scaffold systems. PMID:22080255

Matson, John B.

2012-01-01

434

Current overview on dental stem cells applications in regenerative dentistry  

PubMed Central

Teeth are the most natural, noninvasive source of stem cells. Dental stem cells, which are easy, convenient, and affordable to collect, hold promise for a range of very potential therapeutic applications. We have reviewed the ever-growing literature on dental stem cells archived in Medline using the following key words: Regenerative dentistry, dental stem cells, dental stem cells banking, and stem cells from human exfoliated deciduous teeth. Relevant articles covering topics related to dental stem cells were shortlisted and the facts are compiled. The objective of this review article is to discuss the history of stem cells, different stem cells relevant for dentistry, their isolation approaches, collection, and preservation of dental stem cells along with the current status of dental and medical applications.

Bansal, Ramta; Jain, Aditya

2015-01-01

435

Simple Signaling Molecules for Inductive Bone Regenerative Engineering  

PubMed Central

With greater than 500,000 orthopaedic procedures performed in the United States each year requiring a bone graft, the development of novel graft materials is necessary. We report that some porous polymer/ceramic composite scaffolds possess intrinsic osteoinductivity as shown through their capacity to induce in vivo host osteoid mineralization and in vitro stem cell osteogenesis making them attractive synthetic bone graft substitutes. It was discovered that certain low crystallinity ceramics partially dissociate into simple signaling molecules (i.e., calcium and phosphate ions) that induce stem cells to endogenously produce their own osteoinductive proteins. Review of the literature has uncovered a variety of simple signaling molecules (i.e., gases, ions, and redox reagents) capable of inducing other desirable stem cell differentiation through endogenous growth factor production. Inductive simple signaling molecules, which we have termed inducerons, represent a paradigm shift in the field of regenerative engineering where they can be utilized in place of recombinant protein growth factors. PMID:25019622

Nelson, Stephen J.; Deng, Meng; Sethuraman, Swaminathan; Doty, Stephen B.; Lo, Kevin W. H.; Khan, Yusuf M.; Laurencin, Cato T.

2014-01-01

436

Stem cell recruitment after injury: lessons for regenerative medicine  

PubMed Central

Tissue repair and regeneration are thought to involve resident cell proliferation as well as the selective recruitment of circulating stem and progenitor cell populations through complex signaling cascades. Many of these recruited cells originate from the bone marrow, and specific subpopulations of bone marrow cells have been isolated and used to augment adult tissue regeneration in preclinical models. Clinical studies of cell-based therapies have reported mixed results, however, and a variety of approaches to enhance the regenerative capacity of stem cell therapies are being developed based on emerging insights into the mechanisms of progenitor cell biology and recruitment following injury. This article discusses the function and mechanisms of recruitment of important bone marrow-derived stem and progenitor cell populations following injury, as well as the emerging therapeutic applications targeting these cells. PMID:23164083

Rennert, Robert C; Sorkin, Michael; Garg, Ravi K; Gurtner, Geoffrey C

2013-01-01

437

Treatment Options: Biological Basis of Regenerative Endodontic Procedures  

PubMed Central

Dental trauma occurs frequently in children and often can lead to pulpal necrosis. The occurrence of pulpal necrosis in the permanent but immature tooth represents a challenging clinical situation since the thin and often short roots increase the risk of subsequent fracture. Current approaches for treating the traumatized immature tooth with pulpal necrosis do not reliably achieve the desired clinical outcomes, consisting of healing of apical periodontitis, promotion of continued root development and restoration of the functional competence of pulpal tissue. An optimal approach for treating the immature permanent tooth with a necrotic pulp would be to regenerate functional pulpal tissue. This review summarizes the current literature supporting a biological rationale for considering regenerative endodontic treatment procedures in treating the immature permanent tooth with pulp necrosis. PMID:23439043

Hargreaves, Kenneth M.; Diogenes, Anibal; Teixeira, Fabricio B.

2013-01-01

438

Regenerative fuel cell study for satellites in GEO orbit  

NASA Technical Reports Server (NTRS)

The results of a 12 month study to identify high performance regenerative hydrogen-oxygen fuel cell concepts for geosynchronous satellite application are summarized. Emphasis was placed on concepts with the potential for high energy density and passive means for water and heat management to maximize system reliability. Both polymer membrane and alkaline electrolyte fuel cells were considered, with emphasis on the alkaline cell because of its high performance, advanced state of development, and proven ability to operate in a launch and space environment. Three alkaline system concepts were studied. Results indicate that using near term technology energy densities between 46 and 52 watt-hour/lb can be achieved at efficiencies of 55 percent. Using advanced light weight cell construction which was achieved in experimental cells, composite tankage material for the reactant gases and the reversible stack concept, system energy densities of 115 watt-hours/lb can be projected.

Van Dine, Leslie; Levy, Alexander; Gonzalez-Sanabria, Olga

1987-01-01

439

Hypoxic Signaling During Tissue Repair and Regenerative Medicine  

PubMed Central

In patients with chronic wounds, autologous tissue repair is often not sufficient to heal the wound. These patients might benefit from regenerative medicine or the implantation of a tissue-engineered scaffold. Both wound healing and tissue engineering is dependent on the formation of a microvascular network. This process is highly regulated by hypoxia and the transcription factors hypoxia-inducible factors-1? (HIF-1?) and -2? (HIF-2?). Even though much is known about the function of HIF-1? in wound healing, knowledge about the function of HIF-2? in wound healing is lacking. This review focuses on the function of HIF-1? and HIF-2? in microvascular network formation, wound healing, and therapy strategies. PMID:25365172

Nauta, Tessa D.; van Hinsbergh, Victor W. M.; Koolwijk, Pieter

2014-01-01

440

Solar powered water desalination system with a regenerative fixture  

SciTech Connect

A low pressure, low temperature, solar powered evaporating condensation system to provide relatively large scale conversion of brackish and seawater to fresh water, utilizes a solar radiation frequency selective material covered evaporation chamber, a throat connected elevated condenser containing energy transferring devices for vapor volume reduction to form a condensate which flows through a water-locked barometric leg to maintain the system at the sub-atmospheric pressure. The system is regenerative and includes means whereby the energy removed from the vapor during condensation is returned to the evaporating chamber and is again utilized in the cycle. Egress valves and locks are provided to maintain balanced flow of raw water, condensate and ejection of residuals. Suitable elevation of the condenser above the evaporator would provide for power generation.

Mckeen, J.E.

1980-11-25

441

Bioengineering Heart Muscle: A Paradigm for Regenerative Medicine  

PubMed Central

The idea of extending the lifetime of our organs is as old as humankind, fueled by major advances in organ transplantation, novel drugs, and medical devices. However, true regeneration of human tissue has becoming increasingly plausible only in recent years. The human heart has always been a focus of such efforts, given its notorious inability to repair itself following injury or disease. We discuss here the emerging bioengineering approaches to regeneration of heart muscle as a paradigm for regenerative medicine. Our focus is on biologically inspired strategies for heart regeneration, knowledge gained thus far about how to make a “perfect” heart graft, and the challenges that remain to be addressed for tissue-engineered heart regeneration to become a clinical reality. We emphasize the need for interdisciplinary research and training, as recent progress in the field is largely being made at the interfaces between cardiology, stem cell science, and bioengineering. PMID:21568715

Lui, Kathy O.; Tandon, Nina

2012-01-01

442

Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior  

PubMed Central

The hair follicle (HF) regeneration paradigm provides a unique opportunity for studying the collective behavior of stem cells in living animals. Activation of HF stem cells depends on the core inhibitory BMP and activating WNT signals operating within the HF microenvironment. Additionally, HFs receive multilayered signaling inputs from the extrafollicular macroenvironment, which includes dermis, adipocytes, neighboring HFs, hormones, and external stimuli. These activators/inhibitors are integrated across multiple stem-cell niches to produce dynamic hair growth patterns. Because of their pigmentation, these patterns can be easily studied on live shaved animals. Comparing to autonomous regeneration of one HF, populations of HFs display coupled decision making, allowing for more robust and adaptable regenerative behavior to occur collectively. The generic cellular automata model used to simulate coordinated HF cycling here can be extended to study population-level behavior of other complex biological systems made of cycling elements. PMID:24384813

Plikus, Maksim V.; Chuong, Cheng-Ming

2015-01-01

443

Regenerative Medicine Approach to Reconstruction of the Equine Upper Airway  

PubMed Central

Airway obstruction is a common cause of poor performance in horses. Structural abnormalities (insufficient length, rigidity) can be a cause for the obstruction. Currently, there are a few effective clinical options for reconstruction of the equine larynx. A regenerative medicine approach to reconstruction may provide the capability to stabilize laryngeal structures and to encourage restoration of site-appropriate, functional, and host-derived tissue. The purpose of this study was the histopathological evaluation of (1) decellularization of equine (horse) laryngeal cartilages (epiglottis and arytenoids); (2) the host response to decellularized laryngeal cartilages implanted subcutaneously in a donkey model as a test of biocompatibility; and (3) the use of decellularized laryngeal cartilages in a clinically relevant pilot study in the horse larynx. Equine laryngeal cartilages were found to be sufficiently decellularized and were subsequently implanted subcutaneously in donkeys to test biocompatibility. After 4 weeks, the implanted cartilage was harvested. In the subcutaneous model, the samples did not elicit a rejection or foreign body type reaction and were judged suitable for implantation in a clinically relevant equine model. Implants were placed in the upper airway (arytenoids and epiglottis) of one horse. At 4 weeks, the implants were observed to remodel rapidly and were replaced by dense connective tissue with signs of new hyaline cartilage formation in the arytenoids and by connective tissue containing glandular structures and an epithelial covering in the epiglottis. The results of the present study demonstrate the feasibility of a scaffold-based regenerative medicine approach to reconstruction of the equine upper airway; however, further studies investigating long-term integration, formation of new cartilage, and mechanical properties are needed. PMID:24160675

Grevemeyer, Bernard; Bogdanovic, Lewis; Canton, Stephen; St. Jean, Guy; Cercone, Marta; Ducharme, Norm G.

2014-01-01

444

Mesenchymal stem cell and regenerative medicine: regeneration versus immunomodulatory challenges  

PubMed Central

Mesenchymal Stem cells (MSC) are now presented with the opportunities of multifunctional therapeutic approaches. Several reports are in support of their self-renewal, capacity for multipotent differentiation, and immunomodulatory properties. They are unique to contribute to the regeneration of mesenchymal tissues such as bone, cartilage, muscle, ligament, tendon, and adipose. In addition to promising trials in regenerative medicine, such as in the treatment of major bone defects and myocardial infarction, MSC has shown a therapeutic effect other than direct hematopoiesis support in hematopoietic reconstruction. MSCs are identified by the expression of many molecules including CD105 (SH2) and CD73(SH3/4) and are negative for the hematopoietic markers CD34, CD45, and CD14. Manufacturing of MSC for clinical trials is also an important aspect as their differentiation, homing and Immunomodulatory properties may differ. Their suppressive effects on immune cells, including T cells, B cells, NK cells and DC cells, suggest MSCs as a novel therapy for GVHD and other autoimmune disorders. Since the cells by themselves are non-immunogenic, tissue matching between MSC donor and recipient is not essential and, MSC may be the first cell type able to be used as an “off-the-shelf” therapeutic product. Following a successful transplantation, the migration of MSC to the site of injury refers to the involvement of chemokines and chemokine receptors of respective specificity. It has been demonstrated that cultured MSCs have the ability to engraft into healthy as well as injured tissue and can differentiate into several cell types in vivo, which facilitates MSC to be an ideal tool for regenerative therapy in different disease types. However, some observations have raised questions about the limitations for proper use of MSC considering some critical factors that warn regular clinical use. PMID:23671814

Law, Sujata; Chaudhuri, Samaresh

2013-01-01

445

Compact Water Vapor Exchanger for Regenerative Life Support Systems  

NASA Technical Reports Server (NTRS)

Thermal and environmental control systems for future exploration spacecraft must meet challenging requirements for efficient operation and conservation of resources. Regenerative CO2 removal systems are attractive for these missions because they do not use consumable CO2 absorbers. However, these systems also absorb and vent water to space along with carbon dioxide. This paper describes an innovative device designed to minimize water lost from regenerative CO2 control systems. Design studies and proof-of-concept testing have shown the feasibility of a compact, efficient membrane water vapor exchanger (WVX) that will conserve water while meeting challenging requirements for operation on future spacecraft. Compared to conventional WVX designs, the innovative membrane WVX described here has the potential for high water recovery efficiency, compact size, and very low pressure losses. The key innovation is a method for maintaining highly uniform flow channels in a WVX core built from water-permeable membranes. The proof-of-concept WVX incorporates all the key design features of a prototypical unit, except that it is relatively small scale (1/23 relative to a unit sized for a crew of six) and some components were fabricated using non-prototypical methods. The proof-of-concept WVX achieved over 90% water recovery efficiency in a compact core in good agreement with analysis models. Furthermore the overall pressure drop is very small (less than 0.5 in. H2O, total for both flow streams) and meets requirements for service in environmental control and life support systems on future spacecraft. These results show that the WVX provides very uniform flow through flow channels for both the humid and dry streams. Measurements also show that CO2 diffusion through the water-permeable membranes will have negligible effect on the CO2 partial pressure in the spacecraft atmosphere.

Izenson, Michael G.; Chen, Weibo; Anderson, Molly; Hodgson, Edward

2012-01-01

446

Performance analysis of reciprocating regenerative magnetic heat pumping. Final report  

SciTech Connect

Transient flow phenomena in the regenerator tube of reciprocating magnetic heat pumps have been studied numerically and experimentally. In the numerical study, two approaches were taken: (1) solving the energy balance equations for fluid through a porous bed directly and (2) solving the Navier-Stokes equations with a buoyancy force term in the momentum equation. A flow thermal mixing problem was found in both approaches because of the piston-like motion of the regenerator tube that hinders the development of the temperature. The numerical study results show that a 45 K temperature span can be reached in 10 minutes of charge time through the use of a 7-Tesla magnetic field. Using the second numerical approach, temperature stratification in the regenerator fluid column was clearly indicated through temperature rasters. The study also calculates regenerator efficiency and energy delivery rates when heating load and cooling load are applied. Piecewise variation of the regenerator tube moving speed has been used in the present numerical study to control the mass flow rate, reduce thermal mixing of the flow and thus the regenerative losses. The gadolinium`s adiabatic temperature has been measured under 6.5 Tesla of magnet field and different of operating temperatures ranging from 285 K to 320 K. Three regenerative heat pumping tests have also been conducted based on the Reynolds number of the regenerator tube flow, namely Re=300, Re=450, and Re=750 without loads. Maximum temperature span are 12 & 11 K and 9 K for the case of Re=300, Re=450 and Re=750, respectively. Experimental data are in good agreement with the numerical calculation results, and have been used to calibrate the numerical results and to develop a design database for reciprocating-type room-temperature magnetic heat pumps.

Chen, D.T. [Oak Ridge Associated Universities, Inc., TN (United States); Murphy, R.W.; Mei, V.C.; Chen, F.C.; Lue, J.W.; Lubell, M.S. [Oak Ridge National Lab., TN (United States)

1994-02-01

447

Application of Stem Cell Technology in Dental Regenerative Medicine  

PubMed Central

Significance In this review, we summarize the current literature regarding the isolation and characterization of dental tissue-derived stem cells and address the potential of these cell types for use in regenerative cell transplantation therapy. Recent Advances Looking forward, platforms for the delivery of stem cells via scaffolds and the use of growth factors and cytokines for enhancing dental stem cell self-renewal and differentiation are discussed. Critical Issues We aim to understand the developmental origins of dental tissues in an effort to elucidate the molecular pathways governing the genesis of somatic dental stem cells. The advantages and disadvantages of several dental stem cells are discussed, including the developmental stage and specific locations from which these cells can be purified. In particular, stem cells from human exfoliated deciduous teeth may act as a very practical and easily accessibly reservoir for autologous stem cells and hold the most value in stem cell therapy. Dental pulp stem cells and periodontal ligament stem cells should also be considered for their triple lineage differentiation ability and relative ease of isolation. Further, we address the potentials and limitations of induced pluripotent stem cells as a cell source in dental regenerative. Future Directions From an economical and a practical standpoint, dental stem cell therapy would be most easily applied in the prevention of periodontal ligament detachment and bone atrophy, as well as in the regeneration of dentin-pulp complex. In contrast, cell-based tooth replacement due to decay or other oral pathology seems, at the current time, an untenable approach. PMID:24527351

Feng, Ruoxue; Lengner, Chistopher

2013-01-01

448

Modality-specific axonal regeneration: toward selective regenerative neural interfaces.  

PubMed

Regenerative peripheral nerve interfaces have been proposed as viable alternatives for the natural control of robotic prosthetic devices. However, sensory and motor axons at the neural interface are of mixed sub-modality types, which difficult the specific recording from motor axons and the eliciting of precise sensory modalities through selective stimulation. Here we evaluated the possibility of using type specific neurotrophins to preferentially entice the regeneration of defined axonal populations from transected peripheral nerves into separate compartments. Segregation of mixed sensory fibers from dorsal root ganglion neurons was evaluated in vitro by compartmentalized diffusion delivery of nerve growth factor (NGF) and neurotrophin-3 (NT-3), to preferentially entice the growth of TrkA+ nociceptive and TrkC+ proprioceptive subsets of sensory neurons, respectively. The average axon length in the NGF channel increased 2.5-fold compared to that in saline or NT-3, whereas the number of branches increased threefold in the NT-3 channels. These results were confirmed using a 3D "Y"-shaped in vitro assay showing that the arm containing NGF was able to entice a fivefold increase in axonal length of unbranched fibers. To address if such segregation can be enticed in vivo, a "Y"-shaped tubing was used to allow regeneration of the transected adult rat sciatic nerve into separate compartments filled with either NFG or NT-3. A significant increase in the number of CGRP+ pain fibers were attracted toward the sural nerve, while N-52+ large-diameter axons were observed in the tibial and NT-3 compartments. This study demonstrates the guided enrichment of sensory axons in specific regenerative chambers, and supports the notion that neurotrophic factors can be used to segregate sensory and perhaps motor axons in separate peripheral interfaces. PMID:22016734

Lotfi, Parisa; Garde, Kshitija; Chouhan, Amit K; Bengali, Ebrahim; Romero-Ortega, Mario I

2011-01-01

449

Tuberous sclerosis diagnosed by incidental computed tomography findings of multifocal micronodular pneumocyte hyperplasia: a case report  

PubMed Central

Introduction The majority of multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis complex is diagnosed with the classical clinical triad of seizures, mental retardation, and skin lesions. We report a rare case of tuberous sclerosis complex with no classical clinical findings, which was diagnosed through incidental computed tomography findings of multiple nodular lesions of multifocal micronodular pneumocyte hyperplasia. Case presentation A chest computed tomography scan of a 51-year-old Japanese woman showed multiple nodular ground-glass opacities that were not seen on chest X-ray. Video-assisted thoracoscopic surgery was performed. A histological examination demonstrated type II pneumocyte hyperplasia with thickened fibrotic alveolar septa, which was consistent with multifocal micronodular pneumocyte hyperplasia. Brain magnetic resonance imaging displayed multiple cortical tubers, and abdominal computed tomography showed bilateral renal angiomyolipoma. Our patient was finally diagnosed as having tuberous sclerosis complex with multifocal micronodular pneumocyte hyperplasia, although she had no episodes of epilepsy, no skin lesions, and no family history. Conclusions Multifocal micronodular pneumocyte hyperplasia with latent tuberous sclerosis complex should be considered in the differential diagnosis of multiple ground-glass opacities. PMID:23072249

2012-01-01

450

Differentiating cutaneous squamous cell carcinoma and pseudoepitheliomatous hyperplasia by multiplex qRT-PCR.  

PubMed

Squamous cell carcinoma is the second most common cutaneous malignancy. The diagnosis can occasionally be difficult as there are many lesions that are mimics, clinically and on pathologic examination. One of the most challenging lesions to differentiate from squamous cell carcinoma is pseudoepitheliomatous hyperplasia, a reactive proliferation of the epidermis that can be encountered secondary to a variety of inflammatory and neoplastic conditions. Utilizing the data set from our previously performed DNA microarray studies on formalin-fixed and paraffin-embedded tissue, we found that the genes C15orf48 and KRT9 had a distinct and robust gene expression pattern in distinguishing squamous cell carcinoma from pseudoepitheliomatous hyperplasia. C15orf48 had higher expression than KRT9 in squamous cell carcinoma, but lower expression than KRT9 in pseudoepitheliomatous hyperplasia. We developed and blindly validated a multiplex TaqMan PCR assay that utilizes these two highly discriminatory genes, which can be performed on material extracted from formalin-fixed and paraffin-embedded tissue. The TaqMan assay was able to differentiate squamous cell carcinoma from pseudoepitheliomatous hyperplasia in 54 of 58 cases (93%). Squamous cell carcinoma was accurately identified in 27 of 28 cases (96%); pseudoepitheliomatous hyperplasia in 27 of 30 cases (90%). This multiplex TaqMan PCR assay may be used as a helpful ancillary molecular diagnostic test to accurately distinguish squamous cell carcinoma from pseudoepitheliomatous hyperplasia in challenging cases. PMID:23702732

Su, Albert; Ra, Seong; Li, Xinmin; Zhou, Jian; Binder, Scott

2013-11-01

451

The effects of Toradol on postoperative intimal hyperplasia in a rat carotid endarterectomy model: laboratory research.  

PubMed

Carotid endarterectomy (CEA) and more recently carotid artery stenting are the treatments of choice for atherosclerotic disease of the extracranial carotid arteries; however, early restenosis caused by neointimal hyperplasia confounds surgical therapy. Oxidative stress has been implicated in the progression of intimal hyperplasia. The authors hypothesized that ketorolac tromethamine (Toradol), a nonsteroidal antiinflammatory drug that is a potent cyclooxygenase inhibitor, would decrease oxidative stress and thereby reduce intimal hyperplasia in a rat CEA model. Twenty-nine male Sprague-Dawley rats underwent CEA and were divided into 3 treatment groups as follows: (1) control (placebo), (2) 7.5 mg/kg Toradol, and (3) 10 mg/kg Toradol. Toradol treatment began 2 days before CEA and continued for 2 weeks. Two weeks after endarterectomy, carotid arteries were fixed, harvested, and examined for platelet activity (platelet reactive units), oxidative stress (malondialdehyde and glutathione), and intimal hyperplasia (measured as percentage of luminal stenosis). Platelet activity, malondialdehyde and glutathione, and intimal hyperplasia were all significantly lowered in both 7.5- and 10-mg/kg doses of Toradol versus control. Toradol given daily beginning 2 days before CEA and ending 2 weeks after the procedure was effective at significantly reducing platelet activity, oxidative stress, and intimal hyperplasia development in the rat without any increase in bleeding. Although the mechanism of action of this reduction is not completely understood, one possible explanation may be through the inhibition of reactive oxygen species production. PMID:17942855

Kalapatapu, Venkat R; Satterfield, Leighton; Brown, Aliza T; Hongjiang Chen; Ercal, Nuran; Price, Tulin O; Jie Gao; Ibrahim, Khalil; Moursi, Mohammed M

2007-01-01

452

Space Station Freedom ECLSS: A step toward autonomous regenerative life support systems  

NASA Technical Reports Server (NTRS)

The Environmental Control and Life Support System (ECLSS) is a Freedom Station distributed system with inherent applicability to extensive automation primarily due to its comparatively long control system latencies. These allow longer contemplation times in which to form a more intelligent control strategy and to prevent and diagnose faults. The regenerative nature of the Space Station Freedom ECLSS will contribute closed loop complexities never before encountered in life support systems. A study to determine ECLSS automation approaches has been completed. The ECLSS baseline software and system processes could be augmented with more advanced fault management and regenerative control systems for a more autonomous evolutionary system, as well as serving as a firm foundation for future regenerative life support systems. Emerging advanced software technology and tools can be successfully applied to fault management, but a fully automated life support system will require research and development of regenerative control systems and models. The baseline Environmental Control and Life Support System utilizes ground tests in development of batch chemical and microbial control processes. Long duration regenerative life support systems will require more active chemical and microbial feedback control systems which, in turn, will require advancements in regenerative life support models and tools. These models can be verified using ground and on orbit life support test and operational data, and used in the engineering analysis of proposed intelligent instrumentation feedback and flexible process control technologies for future autonomous regenerative life support systems, including the evolutionary Space Station Freedom ECLSS.

Dewberry, Brandon S.

1990-01-01

453

Scaffold characterization using NLO multimodal microscopy in metrology for regenerative medicine  

NASA Astrophysics Data System (ADS)

Metrology in regenerative medicine aims to develop traceable measurement technologies for characterizing cellular and macromolecule behaviour in regenerative medicine products and processes. One key component in regenerative medicine is using three-dimensional porous scaffolds to guide cells during the regeneration process. The regeneration of specific tissues guided by tissue analogous substrates is dependent on diverse scaffold architectural properties that can be derived quantitatively from scaffolds images. This paper discuss the results obtained with the multimodal NLO microscope recently realized in our laboratory in characterizing 3D tissue engineered (TE) scaffolds colonized from human Mesenchimal stem cells (hMSC), focusing on the study of the three-dimensional metrological parameters.

Mortati, Leonardo; Divieto, Carla; Boffitto, Monica; Sartori, Susanna; Ciardelli, Gianluca; Sassi, Maria Paola

2013-09-01

454

Time-resolved protein dynamics using synchronized Ti sapphire regenerative amplifier/infrared FEL  

SciTech Connect

We have synchronized a femtosecond 5 kHz Ti Sapphire regenerative amplifier (regen) to the Stanford Superconducting Accelerator/Free Electron laser (SCA/FEL) to within 2 picoseconds time jitter. We are using this capability to measure the time resolved spectral evolution of the radical cation band of the initial electron donor from bacterial reaction centers (Rb sphaeroides) after the initiation of electron transfer using a {approximately} 120 fs NIR pulse from the regen. The FEL is used to probe for the appearance of the radical cation band at {approximately} 4 {mu}m.

Stanley, R.J.; Haar, P.; Boxer, S.G. [Stanford Univ., CA (United States)

1995-12-31

455

Multifocal Adenomatous Oncocytic Hyperplasia of the Parotid Gland  

PubMed Central

Multifocal adenomatous oncocytic hyperplasia (MAOH) is a non-neoplastic lesion that is classified as oncocytosis. MAOH is a rare entity of the parotid gland and accounts for approximately 0.1% of salivary gland lesions. Here, we report a case of MAOH of the parotid gland. The patient was a 71-year-old woman who presented with discomfort at the left side of her neck. Fine-needle aspiration cytology of the parotid gland revealed a loose sheet-like cluster of round to polygonal cells with granular cytoplasm against a hemorrhagic background. The cells had round to oval, centrally located nuclei with granular chromatin and without distinct nucleoli. Histologically, the lesion was formed of many variable-sized nodules, comprising oncocyte-like cells with small round nuclei and eosinophilic granular cytoplasm that was positive for mitochondrial antibodies. The diagnosis of MAOH is difficult to make by cytology alone, because the findings overlap with those of other oncocytic lesions. In particular, the cytological findings of MAOH have not been sufficiently reported to date. A correlation of cytology and histology was expected. PMID:25580104

Kinoshita, Yuichi; Harada, Hiroshi; Kobayashi, Tadao K.; Yoshizawa, Katsuhiko; Yuri, Takashi; Takasu, Kosho; Tsubura, Airo; Shikata, Nobuaki

2014-01-01

456

Giant Bilateral Adrenal Myelolipoma with Congenital Adrenal Hyperplasia  

PubMed Central

Myelolipomas are rare and benign neoplasms, predominant of the adrenal glands, consisting of adipose and mature hematopoietic tissue, commonly discovered incidentally with increased use of radiologic imaging. Few cases of giant bilateral adrenal masses are reported, especially in the setting of congenital adrenal hyperplasia (CAH). We report the case of a 39-year-old male with a history of CAH secondary to 21-? hydroxylase deficiency on steroids since childhood, self-discontinued during adolescence, presenting with abdominal distension, fatigue, decreased libido, and easy bruising. Imaging revealed giant bilateral adrenal masses. He subsequently underwent bilateral adrenalectomy found to be myelolipomas measuring 30 × 25 × 20?cm on the left and weighing 4.1?kg and 25 × 20 × 13?cm on the right and weighing 2.7?kg. Adrenal myelolipomas are found to coexist with many other conditions such as Cushing's syndrome, Addison's disease, and CAH. We discuss the association with high adrenocorticotropic hormone (ACTH) states and review the studies involving ACTH as proponent leading to myelolipomas. Massive growth of these tumors, as in our case, can produce compression and hemorrhagic symptoms. We believe it is possible that self-discontinuation of steroids, in the setting of CAH, may have resulted in the growth of his adrenal masses. PMID:25140269

Al-Bahri, S.; Tariq, A.; Lowentritt, B.; Nasrallah, D. V.

2014-01-01

457

CCR2 deficiency decreases intimal hyperplasia after arterial injury.  

PubMed

Monocyte chemoattractant protein (MCP)-1 is upregulated in atherosclerotic plaques and in the media and intima of injured arteries. CC chemokine receptor 2 (CCR2) is the only known functional receptor for MCP-1. Mice deficient in MCP-1 or CCR2 have marked reductions in atherosclerosis. This study examines the effect of CCR2 deficiency in a murine model of femoral arterial injury. Four weeks after injury, arteries from CCR2(-/-) mice showed a 61.4% reduction (P<0.01) in intimal area and a 62% reduction (P<0.05) in intima/media ratio when compared with CCR2(+/+) littermates. The response of CCR2(+/-) mice was not significantly different from that of CCR2(+/+) mice. Five days after injury, the medial proliferation index, determined by bromodeoxyuridine incorporation, was decreased by 59.8% in CCR2(-/-) mice when compared with CCR2(+/+) littermates (P<0.05). Although leukocytes rapidly adhered to the injured arterial surface, there was no significant macrophage infiltration in the arterial wall of either CCR2(-/-) or CCR2(+/+) mice 5 and 28 days after injury. These results demonstrate that CCR2 plays an important role in mediating smooth muscle cell proliferation and intimal hyperplasia in a non-hyperlipidemic model of acute arterial injury. CCR2 may thus be an important target for inhibiting the response to acute arterial injury. PMID:11950690

Roque, Merce; Kim, William J H; Gazdoin, Michaela; Malik, Alia; Reis, Ernane D; Fallon, John T; Badimon, Juan J; Charo, Israel F; Taubman, Mark B

2002-04-01

458

Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome  

PubMed Central

Background: Kaempferia parviflora rhizome is used as a folk medicine in Thailand for the treatment of various symptoms. In the present study, the inhibitory activities of extract from K. parviflora rhizome against 5?-reductase (5?R) were subjected. Furthermore, the effects of the extract from K. parviflorar hizome in benign prostate hyperplasia (BPH) were studied using the model mice. Materials and Methods: Preparations of extracts from the rhizomes of K. parviflora, Curcuma zedoaria and Zingiber officinale, and methoxyflavones isolated from K. parviflora was used for 5?R inhibition assay. The effects of K. parviflora extract on growth suppression for the prostates and seminal vesicles were performed based on the Hershberger's method. The K. parviflora extract was administered to castrated mice for 14 days. Results: K. parviflora extract showed more potent inhibitory activity on 5?R than C. zedoaria and Z. officinale extracts. The active principles were identified as 3,5,7,3’,4’-pentamethoxyflavone and 5,7,3’,4’-tetramethoxyflavone by activity guided fractionation. Furthermore, K. parviflora extract suppressed the weights of prostates and seminal vesicles in BPH model rats by daily administration for 14 days. Conclusion: These results indicate that K. parviflora extract can be a promising agent for the treatment of BPH. PMID:24174827

Murata, Kazuya; Hayashi, Hirotaka; Matsumura, Shinichi; Matsuda, Hideaki

2013-01-01

459

Treatment and health outcomes in adults with congenital adrenal hyperplasia.  

PubMed

Congenital adrenal hyperplasia (CAH) is a genetic disorder caused by defective steroidogenesis that results in glucocorticoid deficiency; the most common underlying mutation is in the gene that encodes 21-hydroxylase. Life-saving glucocorticoid treatment was introduced in the 1950s, and the number of adult patients is now growing; however, no consensus has been reached on the management of CAH beyond childhood. Adult patients are prescribed a variety of glucocorticoids, including hydrocortisone, prednisone, prednisolone, dexamethasone and combinations of these drugs taken in either a circadian or reverse circadian regimen. Despite these personalized treatments, biochemical control of CAH is only achieved in approximately one-third of patients. Some patients have a poor health status, with an increased incidence of obesity and osteoporosis, and impaired fertility and quality of life. The majority of poor health outcomes seem to relate to inadequate treatment rather than the genotype of the patient. Patients receiving high doses of glucocorticoids and the more potent synthetic long-acting glucocorticoids are at an increased risk of obesity, insulin resistance and a reduced quality of life. Further research is required to optimize the treatment of adult patients with CAH and improve health outcomes. PMID:24342885

Han, Thang S; Walker, Brian R; Arlt, Wiebke; Ross, Richard J

2014-02-01

460

Water-induced thermotherapy for benign prostatic hyperplasia.  

PubMed

Water-induced thermotherapy (WIT), administered by the Thermoflex System, represents a novel minimally invasive technique for the treatment of benign prostatic hyperplasia (BPH). The Thermoflex System consists of an extracorporeal heat source and a proprietary closed-loop catheter system. Water, heated to 60 degrees C, is continuously circulated through the catheter to a treatment balloon, which conducts thermal energy to targeted prostatic tissue. The combination of heat and compression reduces the heat sink effect of the circulating blood, thus enhancing the thermal energy transfer to the compressed tissue. WIT treatment is performed using only topical urethral anesthetic, in a single 45-minute session. The 2-year follow-up data from a European multicenter study consisting of 125 patients showed an improvement in peak urine flow of 87.4% (from baseline 8.7 +/- 1.9 to 16.3 +/- 9.1 mL/s) and in the International Prostate Symptom Score (IPSS) of -54.2% (from baseline 24 +/- 5 to 11 +/- 5). Patient tolerance of WIT was rated as "excellent" or "good" in 91.8% of the procedures. WIT is efficacious, simple, and inexpensive, has few side effects, and does not need special probes to monitor prostate or rectum temperature; thus, it can be used in hospitals, outpatient clinics, and doctors' offices. PMID:11108569

Cioanta, I; Muschter, R

2000-12-01

461

Clinical and molecular review of atypical congenital adrenal hyperplasia  

PubMed Central

Congenital adrenal hyperplasia (CAH) is one of the most common inherited metabolic disorders. It comprises a group of autosomal recessive disorders caused by the mutations in the genes encoding for steroidogenic enzymes that involved cortisol synthesis. More than 90% of cases are caused by a defect in the enzyme 21-hydroxylase. Four other enzyme deficiencies (cholesterol side-chain cleavage, 17?-hydroxylase [P450c17], 11?-hydroxylase [P450c11?], 3?-hydroxysteroid dehydrogenase) in the steroid biosynthesis pathway, along with one cholesterol transport protein defect (steroidogenic acute regulatory protein), and one electrontransfer protein (P450 oxidoreductase) account for the remaining cases. The clinical symptoms of the different forms of CAH result from the particular hormones that are deficient and those that are produced in excess. A characteristic feature of CAH is genital ambiguity or disordered sex development, and most variants are associated with glucocorticoid deficiency. However, in the rare forms of CAH other than 21-hydroxylase deficiency so-called "atypical CAH", the clinical and hormonal phenotypes can be more complicated, and are not well recognized. This review will focus on the atypical forms of CAH, including the genetic analyses, and phenotypic correlates. PMID:25883920

2015-01-01

462

Propranolol: a novel treatment for angiolymphoid hyperplasia with eosinophilia.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, idiopathic disease that manifests as dermal or subcutaneous red or brown papules or nodules, most commonly on the head and neck. Histologically, ALHE is characterized by vascular proliferation with epithelioid endothelial cells with surrounding lymphocytic and eosinophilic infiltrate. There may be an accompanying serum eosinophilia and local lymphadenopathy. We report a case of a 32-year-old woman who presented with multiple erythematous nodules in the periauricular area and the vertex of her scalp. The nodules had been present for several months. Surgical removal of one of the lesions confirmed the histological diagnosis of ALHE. The patient was started on oral propranolol (40 mg once daily) in an effort to reduce the vascular component of the lesions. Within 6 weeks, the patient noted that several of the lesions had decreased in size, and all were less erythematous. Propranolol was subsequently stopped within a few months of initiating treatment. One lesion recurred over a year later, and propranolol was then restarted. No new lesions occurred after 2 years of follow-up. PMID:25065811

Horst, C; Kapur, N

2014-10-01

463

Angiolymphoid hyperplasia with eosinophilia occurring in bilateral eyelids  

PubMed Central

Background Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign lesion, primarily occurring in the head and neck. ALHE arising from the ocular adnexa is rare, and the bilateral presentation is especially rare in the eyelids. Case presentation A 64-year-old Japanese man presented with tearing. Multiple nodules, approximately 5 mm in size, were observed in bilateral upper and lower eyelids. Surgical excisions of the both eyelids masses were performed. Histopathological examination of the excised masses demonstrated proliferated blood vessels lined by plump endothelial cells together with a lymphoid and eosinopilic infiltrate, compatible with a diagnosis of ALHE. Flow cytometry studies showed that the mass consisted of mostly CD3-positive cells. During two-year follow-up, no recurrence of the mass was observed and the patient had no subjective symptom of tearing Conclusion ALHE may occur in the bilateral eyelids. The cause of ALHE remains uncertain, but our results of flow cytemetry suggest that T cells are related to the pathogenesis of this disease. PMID:23914723

2013-01-01

464

Angiolymphoid hyperplasia with eosinophilia: good response to photodynamic therapy.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign vascular disease of unknown pathogenesis, that occurs as solitary or multiple nodules or papules. Lesions are located mainly on the head, forehead and neck, and may be persistent and difficult to eradicate. We report a case of ALHE treated with aminolaevulinic acid photodynamic therapy (ALA-PDT). Treatment consisted of two ALA-PDT sessions with a 2-week interval. Clinical evaluation, 8 weeks after treatment, showed marked improvement though not complete regression. The treatment was well tolerated. At follow-up 4 months after treatment, the lesions were stable. We believe that PDT could be an alternative therapeutic approach for ALHE or could be used as a neoadjuvant treatment to reduce lesion size especially where size or site of lesions limits the efficacy or acceptability of other treatments. The lack of cumulative effects allows repeated treatments with ALA-PDT, but long-term follow-up is advised for assessment of recurrence. PMID:19549233

Sotiriou, E; Apalla, Z; Patsatsi, A; Panagiotidou, D Devliotou; Ioannides, D

2009-12-01

465

Benign prostatic hyperplasia and male lower urinary tract symptoms (LUTS)  

PubMed Central

Introduction Lower urinary tract symptoms related to benign prostatic hyperplasia (BPH) and bladder outlet obstruction may affect up to 30% of men in their early 70s. Symptoms can improve without treatment, but the usual course is a slow progression of symptoms, with acute urinary retention occurring in 1% to 2% of men with BPH per year. Methods and outcomes We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of medical, herbal, and surgical treatments? We searched: Medline, Embase, The Cochrane Library, and other important databases up to July 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). Results We found 63 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. Conclusions In this systematic review we present information relating to the effectiveness and safety of the following interventions: 5 alpha-reductase inhibitors, alpha-blockers, beta-sitosterol plant extract, Pygeum africanum, rye grass pollen extract, saw palmetto plant extracts, transurethral electrovaporisation, transurethral Holmium laser enucleation of the prostate, transurethral microwave thermotherapy, transurethral needle ablation, and transurethral resection (including transurethral resection versus transurethral incision, and transurethral resection versus visual laser ablation/laser vaporisation). PMID:21871136

2011-01-01

466

Critical review of lasers in benign prostatic hyperplasia (BPH).  

PubMed

• Laser treatment of benign prostatic hyperplasia has challenged transurethral resection of the prostate (TURP) due to advances in laser technology, better understanding of tissue-laser interactions and growing clinical experience. • Various lasers have been introduced including neodymium: yttrium aluminium garnet (YAG), holmium (Ho):YAG, potassium titanyl phosphate:YAG, thulium(Tm) and diode laser. Based on the different wave-length dependent laser-prostatic tissue interactions, the main techniques are coagulation, vaporization, resection and enucleation. • The present review aims to help urologists to distinguish and to critically evaluate the role of different laser methods in the treatment by using an evidence-based approach. It also details further evidence for use in specific patient groups (in retention, on anticoagulation) and addresses the issues of cost and learning curve. • Coagulation-based techniques have been abandoned; holmium ablation/resection of the prostate has been superseded by the enucleation technique Ho-laser enucleation of the prostate (HoLEP). The short-term efficacy of the emerging laser treatments such as diode and Tm prostatectomy has been suggested by low quality studies. HoLEP and photoselective vaporization of the prostate (PVP) represent valid clinical alternatives to TURP. HoLEP is the most rigorously analysed laser technique with durable efficacy for any prostate size and low early and late morbidity. PVP has grown in acceptance and popularity but long-term results from high quality studies are pending. PMID:21438974

Gravas, Stavros; Bachmann, Alexander; Reich, Oliver; Roehrborn, Claus G; Gilling, Peter J; De La Rosette, Jean

2011-04-01

467

Congenital Adrenal Hyperplasia and Brain Magnetic Resonance Imaging Abnormalities  

PubMed Central

A 15-yr-old male patient with congenital adrenal hyperplasia (CAH) was referred to our department with a one year history of gradual worsening of tremors. He was diagnosed with salt-wasting 21-hydroxylase deficiency CAH at 40 d old and was started on hydrocortisone, fludrocortisone and salt. He was found to have hypertension at 8 yr of age. Detailed investigations failed to detect any cause for secondary hypertension. Physical findings on the current hospitalization objectified obesity, blood pressure of 150/80 mmHg, postural and action tremor, left cerebellar syndrome, reflex tetra pyramidal syndrome and mental decline. Brain magnetic resonance imaging (MRI) showed bilateral periventricular white matter hyperintensity that was more pronounced in the posterior regions and associated with cortico-subcortical atrophy and complete agenesis of the corpus callosum. All investigations for leukoencephalopathy were negative. A diagnosis of brain MRI abnormalities related to CAH was made, and the patient received symptomatic treatment of tremors. Our case report provides evidence of an increased frequency of brain MRI abnormalities in CAH. The literature suggests hormonal imbalance and exposure to excess exogenous glucocorticoids as main probable mechanisms. Thus, in clinical practice, CAH should be considered as one of the possible causes of brain white matter involvement associated with or without cerebral atrophy. PMID:23926386

Samia, Younes-Mhenni; Mahdi, Kamoun; Baha, Zantour; Saida, Jerbi-Ommezine; Tahar, Sfar Mohamed; Habib, Sfar Mohamed

2010-01-01

468

Benign prostatic hyperplasia: An overview of existing treatment  

PubMed Central

Benign prostatic hyperplasia (BPH) is the most common condition in aging men, associated with lower urinary tract symptoms (LUTS). A better understanding of the prostate physiology, function, and pathogenesis has led to the development of promising agents, useful in the management of LUTS in men. The specific approach used to treat BPH depends upon number of factors like age, prostrate size, weight, prostate-specific antigen level, and severity of the symptoms. 5?-reductase inhibitors decrease the production of dihydrotestosterone within the prostate, which results in decreased prostate volume, increased peak urinary flow rate, improvement of symptoms, decreased risk of acute urinary retention, and need for surgical intervention. ?1-adrenergic receptor (?1-AR) antagonists decrease LUTS and increase urinary flow rates in men with symptomatic BPH, but do not reduce the long-term risk of urinary retention or need for surgical intervention. Clinical efficacy of either 5?-reductase inhibitor or ?1-AR antagonist has been further improved by using combination therapy; however, long-term outcomes are still awaited. Many more potential new therapies are under development that may improve the treatment of BPH. This article gives a brief account of rationale and efficacy of different treatment options presently available in the management of BPH. PMID:21455413

Dhingra, Neelima; Bhagwat, Deepak

2011-01-01

469

Micro and bulk analysis of prostate tissues classified as hyperplasia  

NASA Astrophysics Data System (ADS)

BPH (Benign Prostatic Hyperplasia) is the most common benign neoplasm (non cancerous enlargement of the prostate gland), whose prevalence increases with age. The gland, when increased in size, exerts pressure on the urethra, causing obstruction to urine flow. The latter may result in severe urinary tract and kidney conditions. In this work prostate samples from patients diagnosed with BPH were analyzed using synchrotron radiation. Micro-analysis of the hyperplastic samples was carried out on the L-beam