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1

Nodular regenerative hyperplasia related portal hypertension in a patient with hypogammaglobulinaemia  

PubMed Central

Nodular regenerative hyperplasia (NRH) of liver is a relatively rare liver disorder, but a frequent cause of noncirrhotic portal hypertension. We present a lady with common variable immune deficiency who presented with upper gastrointestinal bleeding and deranged liver function tests but preserved synthetic function. Upper gastrointestinal endoscope showed bleeding gastric varices and non-bleeding oesophageal varices. Although her oesophageal varices were eradicated by repeated endoscopic band ligation, the gastric varices failed to resolve after repeated endoscopic histocryl injection and she eventually needed transjugular intrahepatic portosystemic shunt placement. Liver biopsy showed NRH. We review the association of hypogammaglobinaemia and NRH and discuss the appropriate management of portal hypertension in NRH. PMID:23801845

Lal, Barun Kumar; Stanley, Adrian

2013-01-01

2

Nodular regenerative hyperplasia related portal hypertension in a patient with hypogammaglobulinaemia.  

PubMed

Nodular regenerative hyperplasia (NRH) of liver is a relatively rare liver disorder, but a frequent cause of noncirrhotic portal hypertension. We present a lady with common variable immune deficiency who presented with upper gastrointestinal bleeding and deranged liver function tests but preserved synthetic function. Upper gastrointestinal endoscope showed bleeding gastric varices and non-bleeding oesophageal varices. Although her oesophageal varices were eradicated by repeated endoscopic band ligation, the gastric varices failed to resolve after repeated endoscopic histocryl injection and she eventually needed transjugular intrahepatic portosystemic shunt placement. Liver biopsy showed NRH. We review the association of hypogammaglobinaemia and NRH and discuss the appropriate management of portal hypertension in NRH. PMID:23801845

Lal, Barun Kumar; Stanley, Adrian

2013-06-14

3

Nodular regenerative hyperplasia: Evolving concepts on underdiagnosed cause of portal hypertension  

PubMed Central

Nodular regenerative hyperplasia (NRH) is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules. NRH may lead to the development of non-cirrhotic portal hypertension. There are no published systematic population studies on NRH and our current knowledge is limited to case reports and case series. NRH may develop via autoimmune, hematological, infectious, neoplastic, or drug-related causes. The disease is usually asymptomatic, slowly or non-progressive unless complications of portal hypertension develop. Accurate diagnosis is made by histopathology, which demonstrates diffuse micronodular transformation without fibrous septa. Lack of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic liver. While the initial treatment is to address the underlying disease, ultimately the therapy is directed to the management of portal hypertension. The prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal hypertension. In this review we detail the epidemiology, pathogenesis, diagnosis, management, and prognosis of NRH. PMID:21472097

Hartleb, Marek; Gutkowski, Krzysztof; Milkiewicz, Piotr

2011-01-01

4

Anticoagulant therapy for nodular regenerative hyperplasia in a HIV-infected patient  

PubMed Central

Background Nodular regenerative hyperplasia (NRH) has been recently recognized as an emergent cause of liver disease in HIV-infected patients. NRH may cause non-cirrhotic portal hypertension with potentially severe consequences such as refractory ascites, variceal bleeding and hypersplenism. Obliteration of the small intrahepatic portal veins in association with prothrombotic disorders linked to HIV infection itself or anti-retroviral therapy seem to be the causes of NRH and thus the term HIV-associated obliterative portopathy has been proposed. Case Presentation Here we describe a case of a HIV-infected patient with biopsy-proven NRH and listed for liver transplantation (LT) because of refractory ascites and repeated upper gastrointestinal bleedings. A transjugular intrahepatic portosystemic shunt was placed as a bridge to LT and did not improve liver function. However, anticoagulant therapy with low-molecular-weight heparin (LMWH) was associated with rapid improvement in the liver condition and allowed to avoid LT in this patient. Conclusions Thus, this case underscores the relation between thrombophilia and HIV-associated NRH and emphasizes anticoagulant therapy as possible treatment. PMID:20082713

2010-01-01

5

Portal Hypertension, Nodular Regenerative Hyperplasia of the Liver, and Obstructive Portal Venopathy due to Metastatic Breast Cancer  

PubMed Central

Nodular regenerative hyperplasia (NRH) of the liver is associated with noncirrhotic portal hypertension, rheumatologic and hematologic disorders, administration of certain drugs, and other underlying conditions. This report describes a 64-year-old man with clinically presumed cirrhosis who presented to our institution with coffee-ground emesis, esophageal varices, ascites, and encephalopathy. Eleven years earlier he had been treated for breast cancer with mastectomy and chemo-radiotherapy. He died suddenly, and the autopsy showed no evidence of cirrhosis but instead demonstrated NRH with extensive emboli of recurrent breast carcinoma within the portal vein and its intrahepatic branches. Neoplastic occlusion of the portal vein as a cause of presinusoidal noncirrhotic portal hypertension has not previously been reported for metastatic breast carcinoma. This case highlights the importance of obstructive portal venopathy in the pathogenesis of NRH as well as the diagnostic difficulties that may be encountered in determining the cause of portal hypertension. PMID:23984149

Turk, Andrew T.; Szabolcs, Matthias J.; Lefkowitch, Jay H.

2013-01-01

6

NRH Neuroscience Research Center.  

National Technical Information Service (NTIS)

The NRH Neuroscience Research Center (NRC) mission is to promote and accomplish rehabilitation-related basic and applied neuroscience research. AS part of this mission, the NRC: (1) develops new clinical interventions for patients with neurologically base...

A. W. Dromerick, E. Healton

2006-01-01

7

Nodular regenerative hyperplasia of the liver associated with didanosine persists for years even after its interruption  

PubMed Central

The authors describe an HIV-positive patient with nodular regenerative hyperplasia of the liver with non-cirrhotic portal hypertension. Despite stopping the culprit drug, didanosine, the radiologic changes persisted for years. When evaluating liver pathologies, antiretroviral drugs must be included in the differential diagnosis, even when they have been stopped years ago. PMID:22696691

Hofmaenner, Daniel; Kovari, Helen; Weber, Achim; Weishaupt, Dominik; Speck, Roberto F

2011-01-01

8

Portal vein absence and nodular regenerative hyperplasiaof the liver with giant inferior mesenteric vein  

Microsoft Academic Search

.   We present a patient with nodular regenerative hyperplasia of the liver (NRH) and portal vein absence studied with CT, MR\\u000a imaging, and MR angiography. The most striking feature was exuberant hemorrhoids due to a giant hepatofugal inferior mesenteric\\u000a vein. A relationship between unbalanced portal blood flow and nodular regenerative transformation of the liver is suggested\\u000a in this patient.

E. Arana; L. Martí-Bonmatí; V. Martínez; M. Hoyos; H. Montes

1997-01-01

9

Azathioprine induced liver disease: nodular regenerative hyperplasia of the liver and perivenous fibrosis in a patient treated for multiple sclerosis.  

PubMed Central

Azathioprine hepatotoxicity has been described mainly in renal transplant recipients. Most reported cases are related to lesions of the venous system of the liver: peliosis hepatis, veno-occlusive disease of the liver, perisinusoidal fibrosis, and nodular regenerative hyperplasia of the liver. The most common clinical manifestation of these hepatic vascular lesions is portal hypertension. We present a case of nodular regenerative hyperplasia and perivenous fibrosis in a patient receiving azathioprine for multiple sclerosis. Histological abnormalities were similar to those described in renal transplant patients, and azathioprine was the only potential hepatotoxic agent present. Images Figure 1 Figure 2 PMID:2060883

Mion, F; Napoleon, B; Berger, F; Chevallier, M; Bonvoisin, S; Descos, L

1991-01-01

10

Hyperplasia  

MedlinePLUS

Hyperplasia is increased cell production in a normal tissue or organ. Hyperplasia may be a sign of abnormal or precancerous changes. This is called pathologic hyperplasia. It can also be due to the growth ...

11

Intrahepatic bile duct injury and nodular regenerative hyperplasia of the liver in a patient with polyarteritis nodosa.  

PubMed

Although involvement of the hepatic vasculature in patients with polyarteritis nodosa is not unusual, biliary manifestations are very rare. We describe a patient with polyarteritis nodosa presenting with a febrile cholestatic anicteric syndrome. Histological examination of the liver revealed necrotizing arteritis of small hepatic arteries associated with significant lesions of intrahepatic bile ducts of the sclerosing cholangitis type, i.e. fibrous collar around the ducts, periductal inflammation and ductal proliferation. Concomitant nodular regenerative hyperplasia was found, a condition which has rarely been described in association with polyarteritis nodosa. We think that hepatic arteritis compromising arterial blood flow to the liver was responsible for the most likely ischemic nature of the bile duct injury and the nodular regenerative hyperplasia seen in our patient. PMID:9075683

Goritsas, C P; Repanti, M; Papadaki, E; Lazarou, N; Andonopoulos, A P

1997-03-01

12

Lymphofollicular hyperplasia  

MedlinePLUS

Lymphofollicular hyperplasia is an increase in the size of the lymph node follicles. These follicles contain normal white blood ... the bloodstream. See also: Lymphadenitis and lymphangitis Lymphoid hyperplasia

13

Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+ 3 oxidation state) methyltransferase knockout mice. A preliminary report  

SciTech Connect

Arsenic (+ 3 oxidation state) methyltransferase (As3mt) catalyzes reactions which convert inorganic arsenic to methylated metabolites. This study determined whether the As3mt null genotype in the mouse modifies cytotoxic and proliferative effects seen in urinary bladders of wild type mice after exposure to inorganic arsenic. Female wild type C57BL/6 mice and As3mt KO mice were divided into 3 groups each (n = 8) with free access to a diet containing 0, 100 or 150 ppm of arsenic as arsenite (As{sup III}). During the first week of As{sup III} exposure, As3mt KO mice exhibited severe and lethal systemic toxicity. At termination, urinary bladders of both As3mt KO and wild type mice showed hyperplasia by light microscopy. As expected, arsenic-containing granules were found in the superficial urothelial layer of wild type mice. In As3mt KO mice these granules were present in all layers of the bladder epithelium and were more abundant and larger than in wild type mice. Scanning electron microscopy of the bladder urothelium of As3mt KO mice treated with 100 ppm As{sup III} showed extensive superficial necrosis and hyperplastic changes. In As3mt KO mice, livers showed severe acute inflammatory changes and spleen size and lymphoid areas were decreased compared with wild type mice. Thus, diminished arsenic methylation in As3mt KO mice exacerbates systemic toxicity and the effects of As{sup III} on the bladder epithelium, showing that altered kinetic and dynamic behavior of arsenic can affect its toxicity.

Yokohira, Masanao; Arnold, Lora L.; Pennington, Karen L. [Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135 (United States); Suzuki, Shugo [Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135 (United States); Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences (Japan); Kakiuchi-Kiyota, Satoko [Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135 (United States); Herbin-Davis, Karen; Thomas, David J. [Pharmacokinetics Branch, Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711 (United States); Cohen, Samuel M., E-mail: scohen@unmc.ed [Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135 (United States)

2010-07-15

14

NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs  

Microsoft Academic Search

NRH:quinone oxidoreductase 2 (NQO2) is a cytosolic flavoprotein that utilizes NRH as electron donor. The present studies investigate the role of NQO2 in metabolic detoxification\\/activation of quinones and quinone based anti-tumor drugs. Chinese hamster ovary (CHO) cells stably overexpressing cDNA derived mouse NQO2 and mouse keratinocytes from DMBA-induced skin tumors in wild-type and NQO2-null mice were generated. The CHO cells

Claudia M. Celli; Namphuong Tran; Richard Knox; Anil K. Jaiswal

2006-01-01

15

High dynamic solar radio images by combining visibilities from the Giant Meterwave Radio Telescope (GMRT) and the Nancay Radioheliograph (NRH)  

NASA Astrophysics Data System (ADS)

We present first results from an ongoing program of combining data from NRH and GMRT to produce snapshot images of the sun at meter ?. The data processing includes a superposition of complex visibilities from NRH and GMRT, a Fourier Transform and a cleaning multi-scale algorithm. We present results of a) a simulation and b) an observation of a complex noise storm at 327 MHz on August 27, 2002. This illustrates the capacity of the method to produce high dynamic range snapshot images of a complex sun, and shows that composite images are by far better than images from either instrument alone.

Mercier, C.

2006-06-01

16

Regenerative Aerobraking  

Microsoft Academic Search

NASA's exploration goals for Mars and Beyond will require new power systems and in situ resource utilization technologies. Regenerative aerobraking may offer a revolutionary approach for in situ power generation and oxygen harvesting during these exploration missions. In theory, power and oxygen can be collected during aerobraking and stored for later use in orbit or on the planet. This technology

Robert W. Moses

17

NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs.  

PubMed

NRH:quinone oxidoreductase 2 (NQO2) is a cytosolic flavoprotein that utilizes NRH as electron donor. The present studies investigate the role of NQO2 in metabolic detoxification/activation of quinones and quinone based anti-tumor drugs. Chinese hamster ovary (CHO) cells stably overexpressing cDNA derived mouse NQO2 and mouse keratinocytes from DMBA-induced skin tumors in wild-type and NQO2-null mice were generated. The CHO cells overexpressing NQO2 and mouse keratinocytes expressing or deficient in NQO2 were treated with varying concentrations of mitomycin C (MMC), CB1954, MMC analog BMY25067, EO9, menadione and BP-3,6-quinone, in the absence and presence of NRH. The cytotoxicity of the drugs was evaluated by colony formation. The CHO cells overexpressing higher levels of mouse NQO2 showed significantly increased cytotoxicity to menadione, BP-3,6-quinone and to the anti-tumor drugs MMC and CB1954 when compared to CHO cells expressing endogenous NQO2. The cytotoxicity increased in presence of NRH. Similar results were also observed with BMY25067 and EO9 treatments, but to a lesser extent. The results on keratinocytes deficient in NQO2 supported the data from CHO cells. The inclusion of NRH had no effect on cytotoxicity of quinones and drugs in keratinocytes deficient in NQO2. Mouse NQO2 protein was expressed in bacteria, purified and used to study the role of NQO2 in MMC-induced DNA cross-linking. Bacterially expressed and purified NQO2 efficiently catalyzed MMC activation that led to DNA cross-linking. These results concluded that NQO2 plays a significant role in the metabolic activation of both quinones and anti-tumor drugs leading to cytotoxicity and cell death. PMID:16765324

Celli, Claudia M; Tran, Namphuong; Knox, Richard; Jaiswal, Anil K

2006-07-28

18

Regenerative Aerobraking  

NASA Technical Reports Server (NTRS)

NASA's exploration goals for Mars and Beyond will require new power systems and in situ resource utilization technologies. Regenerative aerobraking may offer a revolutionary approach for in situ power generation and oxygen harvesting during these exploration missions. In theory, power and oxygen can be collected during aerobraking and stored for later use in orbit or on the planet. This technology would capture energy and oxygen from the plasma field that occurs naturally during hypersonic entry using well understood principles of magnetohydrodynamics and oxygen filtration. This innovative approach generates resources upon arrival at the operational site, and thus greatly differs from the traditional approach of taking everything you need with you from Earth. Fundamental analysis, computational fluid dynamics, and some testing of experimental hardware have established the basic feasibility of generating power during a Mars entry. Oxygen filtration at conditions consistent with spacecraft entry parameters at Mars has been studied to a lesser extent. Other uses of the MHD power are presented. This paper illustrates how some features of regenerative aerobraking may be applied to support human and robotic missions at Mars.

Moses, Robert W.

2004-01-01

19

Fully relayed regenerative amplifier  

DOEpatents

A regenerative laser apparatus and method using the optical relay concept to maintain high fill factors, to suppress diffraction effects, and to minimize phase distortions in a regenerative amplifier.

Glass, Alexander J. (Berkeley, CA)

1981-01-01

20

Research Councils UK Regenerative  

E-print Network

and nanotechnology, and Energy and its storage. Regenerative medicine #12;BasicBiology Translational MedicineResearch Councils UK Regenerative medicine #12;Regenerative medicine, the approach that seeks testing to make safer medicines. Success in this research field has also led to economic growth for the UK

Berzins, M.

21

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties  

PubMed Central

There are two common forms of NRH-quinone oxidoreductase 2 (NQO2) in the human population resulting from SNP rs1143684. One has phenylalanine at position 47 (NQO2-F47) and the other leucine (NQO2-L47). Using recombinant proteins, we show that these variants have similar steady state kinetic parameters, although NQO2-L47 has a slightly lower specificity constant. NQO2-L47 is less stable towards proteolytic digestion and thermal denaturation than NQO2-F47. Both forms are inhibited by resveratrol, but NQO2-F47 shows negative cooperativity with this inhibitor. Thus these data demonstrate, for the first time, clear biochemical differences between the variants which help explain previous biomedical and epidemiological findings. PMID:24631540

Megarity, Clare F.; Gill, James R.E.; Clare Caraher, M.; Stratford, Ian J.; Nolan, Karen A.; Timson, David J.

2014-01-01

22

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties.  

PubMed

There are two common forms of NRH-quinone oxidoreductase 2 (NQO2) in the human population resulting from SNP rs1143684. One has phenylalanine at position 47 (NQO2-F47) and the other leucine (NQO2-L47). Using recombinant proteins, we show that these variants have similar steady state kinetic parameters, although NQO2-L47 has a slightly lower specificity constant. NQO2-L47 is less stable towards proteolytic digestion and thermal denaturation than NQO2-F47. Both forms are inhibited by resveratrol, but NQO2-F47 shows negative cooperativity with this inhibitor. Thus these data demonstrate, for the first time, clear biochemical differences between the variants which help explain previous biomedical and epidemiological findings. PMID:24631540

Megarity, Clare F; Gill, James R E; Caraher, M Clare; Stratford, Ian J; Nolan, Karen A; Timson, David J

2014-05-01

23

Benign prostate hyperplasia (BPH) - resources  

MedlinePLUS

Resources - benign prostatic hyperplasia (BPH); Prostate enlargement resources; BPH resources ... The following organizations provide information on benign prostatic hyperplasia ( prostate enlargement ... Urology Care Foundation - www. ...

24

Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor  

PubMed Central

NRH:Quinone Oxidoreductase 2 (NQO2) has been described as having no enzymatic activity with nicotinamide adenine dinucleotide (NADH) or NADPH as electron donating cosubstrates. Mitomycin C (MMC) is both a substrate for and a mechanistic inhibitor of the NQO2 homologue NQO1. NRH:quinone oxidoreductase 2 catalysed the reduction of MMC at pH 5.8 with NADH as a co-factor. This reaction results in species that inhibit the NQO2-mediated metabolism of CB1954. In addition, MMC caused an increase in DNA cross-links in a cell line transfected to overexpress NQO2 to an extent comparable to that observed with an isogenic NQO1-expressing cell line. These data indicate that NQO2 may contribute to the metabolism of MMC to cytotoxic species. PMID:17031400

Jamieson, D; Tung, A T Y; Knox, R J; Boddy, A V

2006-01-01

25

Congenital adrenal hyperplasia.  

PubMed

An autosomal recessive disorder, congenital adrenal hyperplasia, results from a deficiency in the activity of one of the five enzymes required for cortisol biosynthesis. More than 90% of cases are related to deficiency in 21-hydroxylase enzyme activity, which is required for the conversion of 17OH-progesterone to 11-deoxycortisol. Treatment of congenital adrenal hyperplasia consists of steroid replacement to ensure normal growth and reproductive potential. PMID:18411104

Hughes, I A

1990-01-01

26

Microscale Regenerative Heat Exchanger  

NASA Technical Reports Server (NTRS)

The device described herein is designed primarily for use as a regenerative heat exchanger in a miniature Stirling engine or Stirling-cycle heat pump. A regenerative heat exchanger (sometimes called, simply, a "regenerator" in the Stirling-engine art) is basically a thermal capacitor: Its role in the Stirling cycle is to alternately accept heat from, then deliver heat to, an oscillating flow of a working fluid between compression and expansion volumes, without introducing an excessive pressure drop. These volumes are at different temperatures, and conduction of heat between these volumes is undesirable because it reduces the energy-conversion efficiency of the Stirling cycle.

Moran, Matthew E.; Stelter, Stephan; Stelter, Manfred

2006-01-01

27

Deficiency of NRH:Quinone Oxidoreductase 2 Increases Susceptibility to 7,12- Dimethylbenz(a)anthracene and Benzo(a)pyrene-Induced Skin Carcinogenesis  

Microsoft Academic Search

NRH:Quinone oxidoreductase 2 (NQO2) is an enzyme that catalyzes the reductive metabolism of quinones. C57BL\\/6 NQO2\\/ mice lacking NQO2 gene expression were generated in our laboratory. The dorsal skin of NQO2-deficient mice was exposed to 7,12-dimethylbenz(a)anthracene (DMBA) or benzo(a)pyrene alone (complete carcinogen) or with 12-O- tetradecanoylphorbol-13-acetate (TPA) (initiation\\/promotion model) to determine the in vivo role of NQO2 in chemical carcinogenesis.

Karim Iskander; Marilene Paquet; Cory Brayton; Anil K. Jaiswal

28

Nanocomposites for Regenerative Medicine  

Microsoft Academic Search

\\u000a This chapter describes properties and applications of nanocomposites in tissue engineering and regenerative medicine with\\u000a an emphasis on the impact of the nanophase on nanocomposite function. The nanophase can be used as a means to engineer new\\u000a physical properties that improve the utility of tissue engineering scaffolds. Several examples of the use of the nanophase\\u000a for mechanical reinforcement or drug

Ryan Hoshi; Antonio R. Webb; Hongjin Qiu; Guillermo A. Ameer

29

Regenerative medicine strategies.  

PubMed

Applications of regenerative medicine technology may offer novel therapies for patients with injuries, end-stage organ failure, or other clinical problems. Currently, patients suffering from diseased and injured organs can be treated with transplanted organs. However, there is a severe shortage of donor organs that is worsening yearly as the population ages and new cases of organ failure increase. Scientists in the field of regenerative medicine and tissue engineering are now applying the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. The stem cell field is also advancing rapidly, opening new avenues for this type of therapy. For example, therapeutic cloning and cellular reprogramming may one day provide a potentially limitless source of cells for tissue engineering applications. While stem cells are still in the research phase, some therapies arising from tissue engineering endeavors have already entered the clinical setting successfully, indicating the promise regenerative medicine holds for the future. PMID:22244387

Atala, Anthony

2012-01-01

30

Hepatoportal Sclerosis as a Cause of Noncirrhotic Portal Hypertension in Patients With HIV  

Microsoft Academic Search

BACKGROUND:Hepatoportal sclerosis (HPS) is a cause of noncirrhotic portal hypertension, with patients typically presenting with variceal bleeding. It is idiopathic in nature but is felt to be due to an abnormality of the intrahepatic vasculature. HPS is characterized by varying degrees of portal fibrosis, sclerosis of portal vein branches and dilatation of sinusoidal spaces. Nodular regenerative hyperplasia (NRH), another cause

Thomas D. Schiano; Donald P. Kotler; Elena Ferran; M. Isabel Fiel

2007-01-01

31

Regenerative rehabilitation: a new future?  

PubMed

Modern rehabilitation medicine is propelled by newfound knowledge aimed at offering solutions for an increasingly aging population afflicted by chronic debilitating conditions. Considered a core component of future health care, the rollout of regenerative medicine underscores a paradigm shift in patient management targeted at restoring physiologic function and restituting normative impact. Nascent regenerative technologies offer unprecedented prospects in achieving repair of degenerated, diseased, or damaged tissues. In this context, principles of regenerative science are increasingly integrated in rehabilitation practices as illustrated in the present Supplement. Encompassing a growing multidisciplinary domain, the emergent era of "regenerative rehabilitation" brings radical innovations at the forefront of healthcare blueprints. PMID:25310603

Perez-Terzic, Carmen; Childers, Martin K

2014-11-01

32

Regenerative adsorbent heat pump  

NASA Technical Reports Server (NTRS)

A regenerative adsorbent heat pump process and system is provided which can regenerate a high percentage of the sensible heat of the system and at least a portion of the heat of adsorption. A series of at least four compressors containing an adsorbent is provided. A large amount of heat is transferred from compressor to compressor so that heat is regenerated. The process and system are useful for air conditioning rooms, providing room heat in the winter or for hot water heating throughout the year, and, in general, for pumping heat from a lower temperature to a higher temperature.

Jones, Jack A. (Inventor)

1991-01-01

33

Regenerative air heater  

DOEpatents

A gas-cooled steel skirt is used to support a refractory cored brick matrix and dome structure in a high temperature regenerative air heater useful in magnetohydrodynamic power generation. The steel skirt thermally expands to accommodate the thermal expansion of the dome structure despite substantial temperature differential thereby reducing relative movement between the dome bricks. Gas cooling of the steel skirt allows the structure to operate above its normal temperature during clean-out cycles and also allows for the control of the thermal expansion of the steel skirt.

Hasselquist, P.B.; Baldner, R.

1980-11-26

34

Nanotechnologies in regenerative medicine.  

PubMed

Nanotechnology offers promising perspectives in biomedical research as well as in clinical practice. To cover some of the latest nanotechnology trends in regenerative medicine, this review will focus on the use of nanomaterials for tissue engineering and cell therapy. Nanofibrous materials that mimic the native extracellular matrix and promote the adhesion of various cells are being developed as tissue-engineered scaffolds for the skin, bone, vasculature, heart, cornea, nervous system, and other tissues. A range of novel materials has been developed to enhance the bioactive or therapeutic properties of these nanofibrous scaffolds via surface modifications, including the immobilization of functional cell-adhesive ligands and bioactive molecules such as drugs, enzymes and cytokines. As a new approach, nanofibers prepared by using industrial scale needleless technology have been recently introduced, and their use as scaffolds to treat spinal cord injury or as cell carriers for the regeneration of the injured cornea is the subject of much current study. Cell therapy is a modern approach of regenerative medicine for the treatment of various diseases or injuries. To follow the migration and fate of transplanted cells, superparamagnetic iron oxide nanoparticles have been developed for cell labeling and non-invasive MRI monitoring of cells in the living organism, with successful applications in, e.g, the central nervous system, heart, liver and kidney and also in pancreatic islet and stem cell transplantation. PMID:20497067

Kubinová, Sárka; Syková, Eva

2010-06-01

35

[Regenerative medicine in cornea].  

PubMed

Cornea is unique organ in its transparency. It consists of three different layers epithelium, stroma, and endothelium. Defect of each layers decrease the transparency resulting in blindness. Corneal transplant from donors is performed for these conditions. However it sometimes does not work because of immuno-rejection and shortage of donors is still problem. Regenerative medicine resolves these problems. According to epithelium, we had succeeded in making epithelial sheet from oral mucosa epithelium. The sheet is clear and very resembles normal corneal epithelium in histology. We have auto transplantation of this epithelial sheet to severe corneal deficiency patients and obtained good clinical results. According to endothelium, we are trying to make the sheet from various stem sells including iPS cells. PMID:22242326

Tsujikawa, Motokazu; Nishida, Kohji

2011-12-01

36

Regenerative braking device  

SciTech Connect

Disclosed are several embodiments of a regenerative braking device for an automotive vehicle. The device includes a plurality of rubber rollers (24, 26) mounted for rotation between an input shaft (14) connectable to the vehicle drivetrain and an output shaft (16) which is drivingly connected to the input shaft by a variable ratio transmission (20). When the transmission ratio is such that the input shaft rotates faster than the output shaft, the rubber rollers are torsionally stressed to accumulate energy, thereby slowing the vehicle. When the transmission ratio is such that the output shaft rotates faster than the input shaft, the rubber rollers are torsionally relaxed to deliver accumulated energy, thereby accelerating or driving the vehicle.

Hoppie, Lyle O. (Birmingham, MI)

1982-01-12

37

Regenerative Therapy for Retinal Disorders  

PubMed Central

Major advances in various disciplines of basic sciences including embryology, molecular and cell biology, genetics, and nanotechnology, as well as stem cell biology have opened new horizons for regenerative therapy. The unique characteristics of stem cells prompt a sound understanding for their use in modern regenerative therapies. This review article discusses stem cells, developmental stages of the eye field, eye field transcriptional factors, and endogenous and exogenous sources of stem cells. Recent studies and challenges in the application of stem cells for retinal pigment epithelial degeneration models will be summarized followed by obstacles facing regenerative therapy. PMID:22737370

Daftarian, Narsis; Kiani, Sahar; Zahabi, Azadeh

2010-01-01

38

Study on regenerative braking of electric vehicle  

Microsoft Academic Search

This paper discusses the regenerative braking system for electric vehicle (EV) that performs regenerative energy recovery based on analytical deduction of several regenerative braking systems with the microscopic view of pulse width modulation (PWM) driving, a constant regenerative current control scheme is proposed, thereby providing improved performance and the energy recovery efficiency at minimum cost. Experimental results of EV show

Zhang Chuanwei; Bai Zhifeng; Cao Binggang; Li Jingcheng

2004-01-01

39

Amlodipine-induced gingival hyperplasia.  

PubMed

Drug-induced gingival hyperplasia is a serious concern both for the patient and the clinician. A 45 year-old Caucasian male patient with hypertension, who received amlodipine (10 mg/day, single dose orally) for two months, sought medical attention because of the new-onset gingival enlargement. On clinical examination a generalized and firm overgrowth of the gingival throughout the maxilla and the mandible were evident. The lack of gingival inflammation and purulent discharge were other features of the clinical scenario. Histological assessment of the biopsy specimen revealed the hyperplasia of connective tissue, epithelial acanthosis, and elongated rete ridges along with few inflammatory cells. The histological and the clinical evidences were consistent with amlodipine-induced gingival hyperplasia. We believe that the present report indicates the most rapidly developed case of amlodipine-induced gingival hyperplasia reported to date. The related literature is reviewed and the underlying pathogenic mechanisms of this rare side-effect are discussed here. PMID:17072250

Lafzi, Ardeshir; Farahani, Ramin Mostofi Zadeh; Shoja, Mohammad Ali Mohajjel

2006-01-01

40

A helium regenerative compressor  

SciTech Connect

This paper discusses the design and performance of a regenerative compressor that was developed primarily for use in cryogenic helium systems. The objectives for the development were to achieve acceptable efficiency in the machine using conventional motor and bearing technology while reducing the complexity of the system required to control contamination from the lubricants. A single stage compressor was built and tested. The compressor incorporates aerodynamically shaped blades on a 218 mm (8.6 inches) diameter impeller to achieve high efficiency. A gas-buffered non-contact shaft seal is used to oppose the diffusion of lubricant from the motor bearings into the cryogenic circuit. Since it is a rotating machine, the flow is continuous and steady, and the machine is very quiet. During performance testing with helium, the single stage machine has demonstrated a pressure ratio of 1.5 at a flow rate of 12 g/s with measured isothermal efficiencies in excess of 30%. This performance compares favorably with efficiencies generally achieved in oil flooded screw compressors.

Swift, W.L.; Nutt, W.E.; Sixsmith, H. [Creare Incorporated, Hanover, NH (United States)

1994-12-31

41

Regenerative switching CMOS system  

DOEpatents

Complementary Metal Oxide Semiconductor (CMOS) Schottky barrier Field Effect Transistor systems, which are a series combination of N and P-Channel MOSFETS, in which Source Schottky barrier junctions of the N and P-Channel Schottky barrier MOSFETS are electrically interconnected, (rather than the Drains as in conventional diffused junction CMOS), which Schottky barrier MOSFET system demonstrates Regenerative Inverting Switching Characteristics in use are disclosed. Both the N and P-Channel Schottky barrier MOSFET devices are unique in that they provide operational Drain Current vs. Drain to Source voltage as a function of Gate voltage only where the polarities of the Drain voltage and Gate voltage are opposite, referenced to the Source as a common terminal, and where the polarity of the voltage applied to the Gate is appropriate to cause Channel inversion. Experimentally derived results which demonstrate and verify the operation of N and P-Channel Schottky barrier MOSFETS actually fabricated on P and N-type Silicon respectively, by a common procedure using vacuum deposited Chromium as a Schottky barrier forming metal, are also provided. 14 figs.

Welch, J.D.

1998-06-02

42

Regenerative switching CMOS system  

DOEpatents

Complementary Metal Oxide Semiconductor (CMOS) Schottky barrier Field Effect Transistor systems, which are a seriesed combination of N and P-Channel MOSFETS, in which Source Schottky barrier junctions of the N and P-Channel Schottky barrier MOSFETS are electically interconnected, (rather than the Drains as in conventional diffused junction CMOS), which Schottky barrier MOSFET system demonstrates Regenerative Inverting Switching Characteristics in use are disclosed. Both the N and P-Channel Schottky barrier MOSFET devices are unique in that they provide operational Drain Current vs. Drain to Source voltage as a function of Gate voltage only where the polarities of the Drain voltage and Gate voltage are opposite, referenced to the Source as a common terminal, and where the polarity of the voltage applied to the Gate is appropriate to cause Channel inversion. Experimentally derived results which demonstrate and verify the operation of N and P-Channel Schottky barrier MOSFETS actually fabricated on P and N-type Silicon respectively, by a common procedure using vacuum deposited Chromium as a Schottky barrier forming metal, are also provided.

Welch, James D. (10328 Pinehurst Ave., Omaha, NE 68124)

1998-01-01

43

Deficiency of NRH:Quinone Oxidoreductase 2 Differentially Regulates TNF Signaling in Keratinocytes: Up-regulation of Apoptosis Correlates with Down-regulation of Cell Survival Kinases  

Microsoft Academic Search

NRH:quinone oxidoreductase 2 (NQO2) is a cytosolic flavopro- tein that catalyzes the two-electron reduction of quinones and quinoid compounds to hydroquinones. Although the role of a homologue, NAD(P)H:quinone oxidoreductase 1 (NQO1), is well defined in oxidative stress, neoplasia, and carcinogenesis, little is known about the mechanism of actions of NQO2 in these cellular responses. Whether NQO2 has any role in

Kwang Seok Ahn; Xing Gong; Gautam Sethi; Madan M. Chaturvedi; Anil K. Jaiswal; Bharat B. Aggarwal

2007-01-01

44

The Biology of Regenerative Medicine  

NSDL National Science Digital Library

The goal of regenerative medicine is to restore the structure and function of human body parts compromised by injury or disease. Regenerative medicine is a relatively new field that uses multiple approaches and has its roots largely in tissue engineering, tissue transplantation, and stem cell biology. It is becoming increasingly clear that advances in the areas of regeneration biology and developmental biology have the potential to transform regenerative medicine, and David Stocum has produced a textbook that attempts to pull everything together for the next generation of regeneration scientists. Regeneration Biology and Medicine is a terrific reference for anyone toying with the idea of moving into this field. The text offers an enormous breath of coverage of different systems currently under investigation, and Stocum provides a central theme that pits regenerative ability against fibrosis as a way to conceptually untangle the limited regenerative capacity of humans. In writing this textbook, Stocum has erected an umbrella large enough for scientists of diverse backgrounds to initiate conceptual cross-talk between those actively involved in the biology of regeneration and those targeting its clinical application.

Ken Muneoka (Tulane University;Department of Cell and Molecular Biology REV)

2007-06-05

45

Regenerative Strategies for Craniofacial Disorders  

PubMed Central

Craniofacial disorders present markedly complicated problems in reconstruction because of the complex interactions of the multiple, simultaneously affected tissues. Regenerative medicine holds promise for new strategies to improve treatment of these disorders. This review addresses current areas of unmet need in craniofacial reconstruction and emphasizes how craniofacial tissues differ from their analogs elsewhere in the body. We present a problem-based approach to illustrate current treatment strategies for various craniofacial disorders, to highlight areas of need, and to suggest regenerative strategies for craniofacial bone, fat, muscle, nerve, and skin. For some tissues, current approaches offer excellent reconstructive solutions using autologous tissue or prosthetic materials. Thus, new “regenerative” approaches would need to offer major advantages in order to be adopted. In other tissues, the unmet need is great, and we suggest the greatest regenerative need is for muscle, skin, and nerve. The advent of composite facial tissue transplantation and the development of regenerative medicine are each likely to add important new paradigms to our treatment of craniofacial disorders. PMID:23248598

Garland, Catharine B.; Pomerantz, Jason H.

2012-01-01

46

Thermoacoustic simulator for regenerative machines  

NASA Astrophysics Data System (ADS)

Linear thermoacoustic theory is a powerful tool to understand the working mechanism of many regenerative machines. Based on the theory, the authors have developed a computer code "Thermoacoustic Simulator" for analyzing and designing different regenerative cryocoolers including String refrigerators, Stirling and G-M types of pulse tube refrigerators and G-M cryocoolers. Also, standing-wave and traveling-wave thermoacoustic machines can be simulated, too. This paper will present the philosophy of the "Thermoacoustic Simulator" and some demonstrations of simulation for different types of cryocoolers and thermoacoustic engines.

Luo, E.; Wu, J.; Yang, J.; Xiao, J.

2002-05-01

47

Regeneratively Cooled Porous Media Jacket  

NASA Technical Reports Server (NTRS)

The fluid and heat transfer theory for regenerative cooling of a rocket combustion chamber with a porous media coolant jacket is presented. This model is used to design a regeneratively cooled rocket or other high temperature engine cooling jacket. Cooling jackets comprising impermeable inner and outer walls, and porous media channels are disclosed. Also disclosed are porous media coolant jackets with additional structures designed to transfer heat directly from the inner wall to the outer wall, and structures designed to direct movement of the coolant fluid from the inner wall to the outer wall. Methods of making such jackets are also disclosed.

Mungas, Greg (Inventor); Fisher, David J. (Inventor); London, Adam Pollok (Inventor); Fryer, Jack Merrill (Inventor)

2013-01-01

48

Regenerative Medicine: Learning from Past Examples  

E-print Network

Regenerative medicine products have characteristically shown great therapeutic potential, but limited market success. Learning from the past attempts at capturing value is critical for new and emerging regenerative medicine ...

Couto, Daniela S.

49

Investigation of a regenerative damping concept  

E-print Network

variety of mechanical systems. Automobiles use waste engine heat to warm fuel prior to combustion, heat passenger compartments, and heat catalysts which remove exhaust pollutants. Regenerative braking systems are being used today in automobiles as well..., regenerative braking and the continuously variable transmission, have similar design goals. The engineering problems of regenerative braking and the continuously variable transmission are similar to those of regenerative damping and provide the only source...

Fodor, Michael Glenn

2012-06-07

50

TREATMENT OF BENIGN PROSTATIC HYPERPLASIA  

Microsoft Academic Search

The treatment of benign prostatic hyperplasia (BPH) has implications which affect the majority of the adult male population. Although benign compared to prostate cancer, clinical symptoms can dramatically alter the quality of life. The hyperplastic tissue can cause constriction of the urethra and thus affect voiding of urine. Factors to consider for thermally-based treatments of the prostate include minimization of

Jonathan W. Valvano; David Y. Yuan; Eric N. Rudie; Steven J. Clark

51

Advanced regenerative heat recovery system  

Microsoft Academic Search

A regenerative heat recovery system was designed and fabricated to deliver 1500 scfm preheated air to a maximum temperature of 1600 F. Since this system is operating at 2000 F, the internal parts were designed to be fabricated with ceramic materials. This system is also designed to be adaptable to an internal metallic structure to operate in the range of

A. Prasad; J. K. Jasti

1982-01-01

52

Regenerative Medicine: Past and Present  

Microsoft Academic Search

Novel therapies resulting from regenerative medicine and tissue engineering technology may offer new hope for patients with injuries, end-stage organ failure, degenerative disorders and many other clinical issues. Currently, patients suffering from diseased and injured organs are treated with transplanted organs. However, there is a shortage of donor organs that is worsening yearly as the population ages and new cases

Anthony Atala

2009-01-01

53

Electrospun Nanofibers for Regenerative Medicine**  

PubMed Central

This article reviews recent progress in applying electrospun nanofibers to the emerging field of regenerative medicine. We begin with a brief introduction to electrospinning and nanofibers, with a focus on issues related to the selection of materials, incorporation of bioactive molecules, degradation characteristics, control of mechanical properties, and facilitation of cell infiltration. We then discuss a number of approaches to fabrication of scaffolds from electrospun nanofibers, including techniques for controlling the alignment of nanofibers and for producing scaffolds with complex architectures. We also highlight applications of the nanofiber-based scaffolds in four areas of regenerative medicine that involve nerves, dural tissues, tendons, and the tendon-to-bone insertion site. We conclude this review with perspectives on challenges and future directions for design, fabrication, and utilization of scaffolds based on electrospun nanofibers. PMID:23184683

Liu, Wenying; Thomopoulos, Stavros

2013-01-01

54

Cardiac Regenerative Capacity and Mechanisms  

PubMed Central

The heart holds the monumental yet monotonous task of maintaining circulation. Although cardiac function is critical to other organs and to life itself, mammals are not equipped with significant natural capacity to replace heart muscle that has been lost by injury. This deficiency plays a role in leaving millions worldwide each year vulnerable to heart failure. By contrast, certain other vertebrate species like zebrafish are strikingly good at heart regeneration. A cellular and molecular understanding of endogenous regenerative mechanisms, combined with advances in methodology to transplant cells, together project a future in which cardiac muscle regeneration can be therapeutically stimulated in injured human hearts. This review will focus on what has been discovered recently about cardiac regenerative capacity and how natural mechanisms of heart regeneration in model systems are stimulated and maintained. PMID:23057748

Kikuchi, Kazu; Poss, Kenneth D.

2013-01-01

55

Nanotechnology Biomimetic Cartilage Regenerative Scaffolds  

PubMed Central

Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an emphasis on the application of nanotechnology in the production of biomimetic cartilage regenerative scaffolds. The structural architecture and composition of the cartilage extracellular matrix and the evolution of tissue engineering concepts and scaffold technology over the last two decades are outlined. Current advances in biomimetic techniques to produce nanoscaled fibrous scaffolds, together with innovative methods to improve scaffold biofunctionality with bioactive cues are highlighted. To date, the majority of research into cartilage regeneration has been focused on articular cartilage due to the high prevalence of large joint osteoarthritis in an increasingly aging population. Nevertheless, the principles and advances are applicable to cartilage engineering for plastic and reconstructive surgery. PMID:24883273

Sardinha, Jose Paulo; Myers, Simon

2014-01-01

56

Benign Prostatic Hyperplasia: An Overview  

PubMed Central

Despite the deceptively simple description of benign prostatic hyperplasia (BPH), the actual relationship between BPH, lower urinary tract symptoms (LUTS), benign prostatic enlargement, and bladder outlet obstruction is complex and requires a solid understanding of the definitional issues involved. The etiology of BPH and LUTS is still poorly understood, but the hormonal hypothesis has many arguments in its favor. There are many medical and minimally invasive treatment options available for affected patients. In the intermediate and long term, minimally invasive treatment options are superior to medical therapy in terms of symptom and flow rate improvement; tissue ablative surgical treatment options are superior to both minimally invasive and medical therapy. PMID:16985902

Roehrborn, Claus G

2005-01-01

57

Advanced regenerative absorption refrigeration cycles  

DOEpatents

Multi-effect regenerative absorption cycles which provide a high coefficient of performance (COP) at relatively high input temperatures. An absorber-coupled double-effect regenerative cycle (ADR cycle) (10) is provided having a single-effect absorption cycle (SEA cycle) (11) as a topping subcycle and a single-effect regenerative absorption cycle (1R cycle) (12) as a bottoming subcycle. The SEA cycle (11) includes a boiler (13), a condenser (21), an expansion device (28), an evaporator (31), and an absorber (40), all operatively connected together. The 1R cycle (12) includes a multistage boiler (48), a multi-stage resorber (51), a multisection regenerator (49) and also uses the condenser (21), expansion device (28) and evaporator (31) of the SEA topping subcycle (11), all operatively connected together. External heat is applied to the SEA boiler (13) for operation up to about 500 degrees F., with most of the high pressure vapor going to the condenser (21) and evaporator (31) being generated by the regenerator (49). The substantially adiabatic and isothermal functioning of the SER subcycle (12) provides a high COP. For higher input temperatures of up to 700 degrees F., another SEA cycle (111) is used as a topping subcycle, with the absorber (140) of the topping subcycle being heat coupled to the boiler (13) of an ADR cycle (10). The 1R cycle (12) itself is an improvement in that all resorber stages (50b-f) have a portion of their output pumped to boiling conduits (71a-f) through the regenerator (49), which conduits are connected to and at the same pressure as the highest pressure stage (48a) of the 1R multistage boiler (48).

Dao, Kim (14 Nace Ave., Piedmont, CA 94611)

1990-01-01

58

Entropy Generation in Regenerative Systems  

NASA Technical Reports Server (NTRS)

Heat exchange to the oscillating flows in regenerative coolers generates entropy. These flows are characterized by oscillating mass flows and oscillating temperatures. Heat is transferred between the flow and heat exchangers and regenerators. In the former case, there is a steady temperature difference between the flow and the heat exchangers. In the latter case, there is no mean temperature difference. In this paper a mathematical model of the entropy generated is developed for both cases. Estimates of the entropy generated by this process are given for oscillating flows in heat exchangers and in regenerators. The practical significance of this entropy is also discussed.

Kittel, Peter

1995-01-01

59

Regenerative superheated steam turbine cycles  

NASA Technical Reports Server (NTRS)

PRESTO computer program was developed to analyze performance of wide range of steam turbine cycles with special attention given to regenerative superheated steam turbine cycles. It can be used to model standard turbine cycles, including such features as process steam extraction, induction and feedwater heating by external sources, peaking, and high back pressure. Expansion line efficiencies, exhaust loss, leakages, mechanical losses, and generator losses are used to calculate cycle heat rate and generator output. Program provides power engineer with flexible aid for design and analysis of steam turbine systems.

Fuller, L. C.; Stovall, T. K.

1980-01-01

60

Regenerative medicine in Alzheimer's disease.  

PubMed

Identifying novel, effective therapeutics for Alzheimer's disease (AD) is one of the major unmet medical needs for the coming decade. Because the current paradigm for developing and testing disease-modifying AD therapies is protracted and likely to be even longer, with the shift toward earlier intervention in preclinical AD, it is an open issue whether we can develop, test, and widely deploy a novel therapy in time to help the current at-risk generation if we continue to follow the standard paradigms of discovery and drug development. There is an imperative need to find safe and effective preventive measures that can be distributed rapidly to stem the coming wave of AD that will potentially engulf the next generation. We can define regenerative medicine broadly as approaches that use stem cell-based therapies or approaches that seek to modulate inherent neurogenesis. Neurogenesis, although most active during prenatal development, has been shown to continue in several small parts of the brain, including the hippocampus and the subventricular zone, suggesting its potential to reverse cognitive deficits. If AD pathology affects neurogenesis, then it follows that conditions that stimulate endogenous neurogenesis (eg, environmental stimuli, physical activity, trophic factors, cytokines, and drugs) may help to promote the regenerative and recovery process. Herein, we review the complex logistics of potentially implementing neurogenesis-based therapeutic strategies for the treatment of AD. PMID:24286919

Felsenstein, Kevin M; Candelario, Kate M; Steindler, Dennis A; Borchelt, David R

2014-04-01

61

PWM regenerative rectifiers: state of the art  

Microsoft Academic Search

New regulations impose more stringent limits on current harmonics injected by power converters that are achieved with pulsewidth-modulated (PWM) rectifiers. In addition, several applications demand the capability of power regeneration to the power supply. This work presents the state of the art in the field of regenerative rectifiers with reduced input harmonics and improved power factor. Regenerative rectifiers are able

José R. Rodríguez; Juan W. Dixon; José R. Espinoza; Jorge Pontt; Pablo Lezana

2005-01-01

62

Optimization of parallel regenerative braking control strategy  

Microsoft Academic Search

Regenerative braking system is the own system of electric and hybrid electric vehicle. The system can restore the kinetic energy and potential energy, used during start and accelerating, into battery through electrical machine. The total brake force is composed of friction brake force on front axel, friction brake force on rear axel and regenerative brake force when a vehicle equipped

Zhang Jingming; Song Baoyu; Niu Xiaojing

2008-01-01

63

Studies of regenerative braking in electric vehicle  

Microsoft Academic Search

Generally the braking system for a car is based on hydraulic braking technology. However, this traditional braking methodology causes a lot of energy wastage since it produces unwanted heat during braking. Thus, the invention of regenerative braking in electric car has overcome these disadvantages moreover it helps in save energy and provides higher efficiency for a car. In regenerative mode,

M. K. Yoong; Y. H. Gan; G. D. Gan; C. K. Leong; Z. Y. Phuan; B. K. Cheah; K. W. Chew

2010-01-01

64

Regenerative braking strategy for electric vehicles  

Microsoft Academic Search

Regenerative braking is an effective approach for electric vehicles to extend their driving range. The control strategy of regenerative braking plays an important role in maintaining the vehicle's stability and recovering energy. In this paper, the main properties that have influence on brake energy regeneration are analyzed. Mathematical model of brake energy regenerating electric vehicles is established. By analyzing the

Jingang Guo; Junping Wang; Binggang Cao

2009-01-01

65

Congenital adrenal hyperplasia and pregnancy.  

PubMed

A 32-year-old woman with classical congenital adrenal hyperplasia (CAH) secondary to 21-hydroxylase deficiency presented with infertility. She was treated with different steroid replacement regimens together with fludrocortisone. The aim of this case report is to discuss fertility barriers in women with classical CAH, and emphasise the risks and benefits of available steroid treatment options. Clinical considerations covered include preconception health and fertility planning, optimising fertility through suppression of excess hormone production, reducing fetal androgen exposure in utero and limiting maternal and fetal side effects of therapy and limiting chances of CAH in the baby. In this case suppression of androgen and progesterone levels was challenging but eventually was achieved and resulted in a spontaneous pregnancy. However, she miscarried in the first trimester, and fetal biopsy revealed a complete hydatiform mole. She is advised not to conceive while she is under investigation to determine the extent of the disease. PMID:23917362

Shorakae, Soulmaz; Teede, Helena

2013-01-01

66

Unitized regenerative fuel cell system  

NASA Technical Reports Server (NTRS)

A Unitized Regenerative Fuel Cell system uses heat pipes to convey waste heat from the fuel cell stack to the reactant storage tanks. The storage tanks act as heat sinks/sources and as passive radiators of the waste heat from the fuel cell stack. During charge up, i.e., the electrolytic process, gases are conveyed to the reactant storage tanks by way of tubes that include dryers. Reactant gases moving through the dryers give up energy to the cold tanks, causing water vapor in with the gases to condense and freeze on the internal surfaces of the dryer. During operation in its fuel cell mode, the heat pipes convey waste heat from the fuel cell stack to the respective reactant storage tanks, thereby heating them such that the reactant gases, as they pass though the respective dryers on their way to the fuel cell stacks retrieve the water previously removed.

Burke, Kenneth A. (Inventor)

2008-01-01

67

Variable ratio regenerative braking device  

DOEpatents

Disclosed is a regenerative braking device (10) for an automotive vehicle. The device includes an energy storage assembly (12) having a plurality of rubber rollers (26, 28) mounted for rotation between an input shaft (36) and an output shaft (42), clutches (38, 46) and brakes (40, 48) associated with each shaft, and a continuously variable transmission (22) connectable to a vehicle drivetrain and to the input and output shafts by the respective clutches. The rubber rollers are torsionally stressed to accumulate energy from the vehicle when the input shaft is clutched to the transmission while the brake on the output shaft is applied, and are torsionally relaxed to deliver energy to the vehicle when the output shaft is clutched to the transmission while the brake on the input shaft is applied. The transmission ratio is varied to control the rate of energy accumulation and delivery for a given rotational speed of the vehicle drivetrain.

Hoppie, Lyle O. (Birmingham, MI)

1981-12-15

68

Unitized regenerative fuel cell systems  

SciTech Connect

Energy storage systems with extremely high specific energy (>400 Wh/kg) have been designed that use lightweight pressure vessels to contain the gases generated by reversible (unitized) regenerative fuel cells (URFCs).[1] URFC systems are being designed and developed for a variety of applications, including high altitude long endurance (HALE) solar rechargeable aircraft (SRA), zero emission vehicles (ZEVs), hybrid energy storage/propulsion systems for spacecraft, energy storage for remote (off-grid) power sources, and peak shaving for on-grid applications.[1-10] Energy storage for HALE SRA was the original application for this set of innovations, and a prototype solar powered aircraft (Pathfinder-Plus) recently set another altitude record for all propeller-driven aircraft on August 6, 1998, when it flew to 80,285 feet (24.47 km).[11

Mitlitsky, F; Molter, T M; Myers, B; Weisberg, A H

1998-09-10

69

Modeling regenerative braking and storage for vehicles  

SciTech Connect

The fuel savings benefits of regenerative braking and storage for vehicles are often described but not quantified. For example, the federal government and automobile manufacturers are sponsoring a Program for a New Generation of Vehicles (PGNV) with a goal of obtaining a performance of 80 mpg in a family size car. It is typically suggested that such a vehicle will be a hybrid engine and electric drive with regenerative braking. The authors note that while regenerative braking has the potential of saving fuel, it may also do more harm than good as a result of additional weight, less than ideal charge/discharge efficiency on the batteries or storage flywheels and the limited portion of the entire driving cycle when regenerative braking can be utilized. The authors also noted that if regenerative braking can have a net benefit, it would be on a heavy vehicle such as a municipal bus because of the frequent stop and go requirements for both traffic light and passengers. Thus the authors initiated a study of regenerative braking on such a vehicle. The resulting analysis presented in this paper includes data following municipal buses to define the driving cycle, modeling the bus power requirements from weight, aerodynamics and rolling resistance, and then calculating the fuel saving that could result from an ideal regenerative braking system.

Wicks, F.; Donnelly, K. [Union Coll., Schenectady, NY (United States)

1997-12-31

70

Regenerative braking system for a hybrid electric vehicle  

Microsoft Academic Search

This paper discusses a regenerative braking system (RBS) for a parallel hybrid electric vehicle (PHEV) that performs regenerative energy recovery based on vehicle attributes, thereby providing improved performance, efficiency and reliability at minimal additional cost. A detailed description of the regenerative braking algorithm is presented along with simulation results from a dynamic model of the PHEV exhibiting the regenerative braking

S. R. Cikanek; K. E. Bailey

2002-01-01

71

Dissecting the mechanisms of Notch induced hyperplasia  

PubMed Central

The outcome of the Notch pathway on proliferation depends on cellular context, being growth promotion in some, including several cancers, and growth inhibition in others. Such disparate outcomes are evident in Drosophila wing discs, where Notch overactivation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms, we have used genomic strategies to identify the Notch-CSL target genes directly activated during wing disc hyperplasia. Among them were genes involved in both autonomous and non-autonomous regulation of proliferation, growth and cell death, providing molecular explanations for many characteristics of Notch induced wing disc hyperplasia previously reported. The Notch targets exhibit different response patterns, which are shaped by both positive and negative feed-forward regulation between the Notch targets themselves. We propose, therefore, that both the characteristics of the direct Notch targets and their cross-regulatory relationships are important in coordinating the pattern of hyperplasia. PMID:23232763

Djiane, Alexandre; Krejci, Alena; Bernard, Frederic; Fexova, Silvie; Millen, Katherine; Bray, Sarah J

2013-01-01

72

Management of adolescents with congenital adrenal hyperplasia  

PubMed Central

The management of congenital adrenal hyperplasia involves suppression of adrenal androgen production, in addition to treatment of adrenal insufficiency. Management of adolescents with congenital adrenal hyperplasia is especially challenging because changes in the hormonal milieu during puberty can lead to inadequate suppression of adrenal androgens, psychosocial issues often affect adherence to medical therapy, and sexual function plays a major part in adolescence and young adulthood. For these reasons, treatment regimen reassessment is indicated during adolescence. Patients with non-classic congenital adrenal hyperplasia require reassessment regarding the need for glucocorticoid drug treatment. No clinical trials have compared various regimens for classic congenital adrenal hyperplasia in adults, thus therapy is individualised and based on the prevention of adverse outcomes. Extensive patient education is key during transition from paediatric care to adult care and should include education of females with classic congenital adrenal hyperplasia regarding their genital anatomy and surgical history. Common issues for these patients include urinary incontinence, vaginal stenosis, clitoral pain, and cosmetic concerns; for males with classic congenital adrenal hyperplasia, common issues include testicular adrenal rest tumours. Transition from paediatric to adult care is most successful when phased over many years. Education of health-care providers on how to successfully transition patients is greatly needed. PMID:24622419

Merke, Deborah P; Poppas, Dix P

2014-01-01

73

Double regenerative amplification of picosecond pulses  

NASA Astrophysics Data System (ADS)

An double Nd:YAG regenerative amplification picosecond pulse laser is demonstrated under the semiconductor saturable absorption mirror(SESAM) mode-locking technology and regenerative amplification technology, using BBO crystal as PC electro-optic crystal. The laser obtained is 20.71ps pulse width at 10 KHz repetition rate, and the energy power is up to 4W which is much larger than the system without pre-amplification. This result will lay a foundation for the following amplification.

Bai, Zhen-ao; Chen, Li-yuan; Bai, Zhen-xu; Chen, Meng; Li, Gang

2012-04-01

74

[Pseudoangiomatous hyperplasia of mammary stroma].  

PubMed

Four cases of pseudoangiomatous hyperplasia of mammary stroma (PAH) were described (3 women and 1 man aged 15 to 42 years). Clinically in women, they presented as firm, nontender, movable nodules, 1 to 4 cm in diameter, diagnosed clinically usually as fibroadenoma. In the male patient, the lesion was tender, resembling gynecomastia. Microscopically, they were characterized by the presence of anastomosing, empty-looking, slit-shaped spaces irregularly lined by the spindle cells with small, uniformly ovoid nuclei, dispersed throughout the mammary stroma. Immunohistochemically, these cells were vimentin positive, factor VIII and CD31 negative. They did not express estrogen receptor, in one case there was a weak progesteron receptor positivity. Ultrastructurally, the lining cells were of a fibroblastic character. The pathogenesis of PAH is unclear, presumed to be of reactive nature by the authors, probably as an exuberant reaction of stromal cells to hormonal stimuli. In differential diagnosis, PAH should be distinguished from low-grade angiosarcoma, as well as from perilobular hemangioma, diffuse angiomatosis and vascular anomalies. PMID:9750424

Hovorková, E; Ryska, A; Spacek, J

1998-07-01

75

High power regenerative laser amplifier  

DOEpatents

A regenerative amplifier design capable of operating at high energy per pulse, for instance, from 20-100 Joules, at moderate repetition rates, for instance from 5-20 Hertz is provided. The laser amplifier comprises a gain medium and source of pump energy coupled with the gain medium; a Pockels cell, which rotates an incident beam in response to application of a control signal; an optical relay system defining a first relay plane near the gain medium and a second relay plane near the rotator; and a plurality of reflectors configured to define an optical path through the gain medium, optical relay and Pockels cell, such that each transit of the optical path includes at least one pass through the gain medium and only one pass through the Pockels cell. An input coupler, and an output coupler are provided, implemented by a single polarizer. A control circuit coupled to the Pockels cell generates the control signal in timed relationship with the input pulse so that the input pulse is captured by the input coupler and proceeds through at least one transit of the optical path, and then the control signal is applied to cause rotation of the pulse to a polarization reflected by the polarizer, after which the captured pulse passes through the gain medium at least once more and is reflected out of the optical path by the polarizer before passing through the rotator again to provide an amplified pulse.

Miller, John L. (Livermore, CA); Hackel, Lloyd A. (Livermore, CA); Dane, Clifford B. (Dublin, CA); Zapata, Luis E. (Livermore, CA)

1994-01-01

76

High power regenerative laser amplifier  

DOEpatents

A regenerative amplifier design capable of operating at high energy per pulse, for instance, from 20-100 Joules, at moderate repetition rates, for instance from 5-20 Hertz is provided. The laser amplifier comprises a gain medium and source of pump energy coupled with the gain medium; a Pockels cell, which rotates an incident beam in response to application of a control signal; an optical relay system defining a first relay plane near the gain medium and a second relay plane near the rotator; and a plurality of reflectors configured to define an optical path through the gain medium, optical relay and Pockels cell, such that each transit of the optical path includes at least one pass through the gain medium and only one pass through the Pockels cell. An input coupler, and an output coupler are provided, implemented by a single polarizer. A control circuit coupled to the Pockels cell generates the control signal in timed relationship with the input pulse so that the input pulse is captured by the input coupler and proceeds through at least one transit of the optical path, and then the control signal is applied to cause rotation of the pulse to a polarization reflected by the polarizer, after which the captured pulse passes through the gain medium at least once more and is reflected out of the optical path by the polarizer before passing through the rotator again to provide an amplified pulse. 7 figures.

Miller, J.L.; Hackel, L.A.; Dane, C.B.; Zapata, L.E.

1994-02-08

77

Staged regenerative sorption heat pump  

NASA Technical Reports Server (NTRS)

A regenerative adsorbent heat pump process and system for cooling and heating a space. A sorbent is confined in a plurality of compressors of which at least four are first stage and at least four are second stage. The first stage operates over a first pressure region and the second stage over a second pressure region which is higher than the first. Sorbate from the first stage enters the second stage. The sorbate loop includes a condenser, expansion valve, evaporator and the compressors. A single sorbate loop can be employed for single-temperature-control such as air conditioning and heating. Two sorbate loops can be used for two-temperature-control as in a refrigerator and freezer. The evaporator temperatures control the freezer and refrigerator temperatures. Alternatively the refrigerator temperature can be cooled by the freezer with one sorbate loop. A heat transfer fluid is circulated in a closed loop which includes a radiator and the compressors. Low temperature heat is exhausted by the radiator. High temperature heat is added to the heat transfer fluid entering the compressors which are desorbing vapor. Heat is transferred from compressors which are sorbing vapor to the heat transfer fluid, and from the heat transfer fluid to the compressors which are desorbing vapor. Each compressor is subjected to the following phases, heating to its highest temperature, cooling down from its highest temperature, cooling to its lowest temperature, and warming up from its lowest temperature. The phases are repeated to complete a cycle and regenerate heat.

Jones, Jack A. (Inventor)

1995-01-01

78

Regenerative rotary displacer Stirling engine  

SciTech Connect

A few rotary displacer Stirling engines in which the displacer has one gas pocket space at one side and rotates in a main enclosed cylinder, which is heated from one side and cooled from opposite side without any regenerator, have been studied for some time by the authors. The authors tried to improve this engine by equipping it with a regenerator, because without a regenerator, pressure oscillation and efficiency are too small. Here, several types of regenerative rotary displacer piston Stirling engines are proposed. One is the contra-rotating tandem two disc type displacer engine using axial heat conduction through side walls or by heat pipes and another is a single disc type with circulating fluid regenerator or heat pipes. Stirling engines of this new rotary displacer type are thought to attain high speed. Here, experimental results of the original rotary displacer Stirling engine without a regenerator, and one contra-rotating tandem displacer engine with side wall regenerator by axial heat conduction are reported accompanied with a discussion of the results.

Isshiki, Naotsugu; Watanabe, Hiroichi [Nihon Univ. Tokyo (Japan); Raggi, L. [Waseda Univ., Tokyo (Japan); Isshiki, Seita; Hirata, Koichi

1996-12-31

79

Regenerative medicine of the gastrointestinal tract.  

PubMed

Regenerative biology/tissue engineering offers potential solutions for the repair and augmentation of diseased tissues and organs. Tissue engineering technology platforms currently under development for organ regeneration may function in part by recapitulating key mechanistic and signaling pathways associated with embryonic organogenesis. Temporal observations of observed morphological outcomes from the regeneration of tubular organs provide insights into the mechanisms of action associated with the activation of regenerative pathways in preclinical animal models and humans. These include induction of a neo-blastema, regeneration of laminarily organized mural elements (i.e., lamina propria, sub-mucosa, and muscularis), and formation of context appropriate transitional junctions at the point of anastomosis with other tissue elements. These results provide the foundation for a regenerative technology applicable to hollow organs of the gastrointestinal (GI) tract including esophagus and small intestine. Factors affecting the efficacy of observed regenerative outcomes within the GI tract include the roles of vascularization, innervations, and mesenchymal signaling. These will be discussed in the context of an overall mechanism of adult regeneration potentially applicable by the tissue engineering and regenerative medicine industry for continued development of hollow neo-organ products. PMID:24285671

Basu, Joydeep; Bertram, Timothy A

2014-01-01

80

Regenerative principles enrich cardiac rehabilitation practice.  

PubMed

Cardiovascular morbidity imposes a high degree of disability and mortality, with limited therapeutic options available in end-stage disease. Integral to standard of care, cardiac rehabilitation aims on improving quality-of-life and prolonging survival. The recent advent of regenerative technologies paves the way for a transformative era in rehabilitation medicine whereby, beyond controlling risk factors and disease progression, the prospect of curative solutions is increasingly tangible. To date, the spectrum of clinical experience in cardiac regenerative medicine relies on stem cell-based therapies delivered to the diseased myocardium either acutely/subacutely, after a coronary event, or in the setting of chronic heart failure. Application of autologous/allogeneic stem cell platforms has established safety and feasibility, with encouraging signals of efficacy. Newer protocols aim to purify cell populations in an attempt to eliminate nonregenerative and enrich for regenerative cell types before use. Most advanced technologies have been developed to isolate resident cell populations directly from the heart or, alternatively, condition cells from noncardiac sources to attain a disease-targeted lineage-specified phenotype for optimized outcome. Because a multiplicity of cell-based technologies has undergone phase I/II evaluation, pivotal trials are currently underway in larger patient populations. Translation of regenerative principles into clinical practice will increasingly involve rehabilitation providers across the continuum of patient care. Regenerative rehabilitation is thus an emerging multidisciplinary field, full of opportunities and ready to be explored. PMID:25313663

Behfar, Atta; Terzic, Andre; Perez-Terzic, Carmen M

2014-11-01

81

Treatment options for benign prostatic hyperplasia.  

PubMed Central

OBJECTIVE: To examine current treatment options for benign prostatic hyperplasia with emphasis on randomized, clinical trials and our current management approach. QUALITY OF EVIDENCE: Benign prostatic hyperplasia remains difficult to define clinically or measure objectively. As a result, research has been fairly weak. With newer treatments, however, more definitive studies have been reported. MAIN FINDINGS: Transurethral resection of the prostate remains the criterion standard for severe disease. Watchful waiting, medical management, or early surgical intervention are all valid options for moderate disease and should be tailored to the characteristics and desires of individual patients. Recent minimally invasive surgical techniques, such as microwave and laser surgery, have not yet achieved the quality of evidence to be generally recommended. CONCLUSIONS: Management of benign prostatic hyperplasia should be individualized to patients' circumstances and personal choices. PMID:9266125

Portis, A. J.; Mador, D. R.

1997-01-01

82

Pseudocarcinomatous hyperplasia of the urinary bladder.  

PubMed

We review the morphology and differential diagnoses of pseudocarcinomatous hyperplasia of the bladder, using a study case to illustrate the discussion. Pseudocarcinomatous hyperplasia is a rare, reactive response to an ischemic insult, classically to radiation therapy, and consists of proliferative, pseudoinfiltrative urothelial nests within the stroma. The presence of background radiation therapy-related changes, such as numerous dilated thrombosed vessels, reactive-appearing endothelial and stromal cells, edema, and hemorrhage, can provide clues to the diagnosis. The main differential diagnoses include invasive urothelial carcinoma and the nested variant of urothelial carcinoma; morphologic features, such as the presence or absence of background therapy-related changes and the architecture and the cytologic atypia of the nests, can help distinguish between pseudocarcinomatous hyperplasia and urothelial carcinoma. PMID:25268187

Wu, Angela

2014-10-01

83

Combined hydraulic and regenerative braking system  

DOEpatents

A combined hydraulic and regenerative braking system and method for an electric vehicle, with the braking system being responsive to the applied hydraulic pressure in a brake line to control the braking of the vehicle to be completely hydraulic up to a first level of brake line pressure, to be partially hydraulic at a constant braking force and partially regenerative at a linearly increasing braking force from the first level of applied brake line pressure to a higher second level of brake line pressure, to be partially hydraulic at a linearly increasing braking force and partially regenerative at a linearly decreasing braking force from the second level of applied line pressure to a third and higher level of applied line pressure, and to be completely hydraulic at a linearly increasing braking force from the third level to all higher applied levels of line pressure.

Venkataperumal, Rama R. (Troy, MI); Mericle, Gerald E. (Mount Clemens, MI)

1981-06-02

84

Regenerative medicine: learning from past examples.  

PubMed

Regenerative medicine products have characteristically shown great therapeutic potential, but limited market success. Learning from the past attempts at capturing value is critical for new and emerging regenerative medicine therapies to define and evolve their business models as new therapies emerge and others mature. We propose a framework that analyzes technological developments along with alternative business models and illustrates how to use both strategically to map value capture by companies in regenerative medicine. We analyze how to balance flexibility of the supply chain and clarity in the regulatory pathway for each business model and propose the possible pathways of evolution between business models. We also drive analogies between cell-based therapies and other healthcare products such as biologicals and medical devices and suggest how to strategically evolve from these areas into the cell therapy space. PMID:22697402

Couto, Daniela S; Perez-Breva, Luis; Cooney, Charles L

2012-11-01

85

Combined hydraulic and regenerative braking system  

SciTech Connect

A combined hydraulic and regenerative braking system and method is disclosed for an electric vehicle. The braking system being responsive to the applied hydraulic pressure in a brake line to control the braking of the vehicle to be completely hydraulic up to a first level of brake line pressure, to be partially hydraulic at a constant braking force and partially regenerative at a linearly increasing braking force from the first level of applied brake line pressure to a higher second level of brake line pressure, to be partially hydraulic at a linearly increasing braking force and partially regenerative at a linearly decreasing braking force from the second level of applied line pressure to a third and higher level of applied line pressure, and to be completely hydraulic at a linearly increasing braking force from the third level to all higher applied levels of line pressure.

Mericle, G.E.; Venkataperumal, R.R.

1981-06-02

86

Enhanced external counterpulsation is a regenerative therapy.  

PubMed

Enhanced external counterpulsation (EECP) is used for the treatment of severe angina and heart failure in patients who are not candidates for revascularization. The clinical benefits of EECP extend well beyond the time period of any hemodynamic effects, but the cause of this prolonged effect is not understood. The prolonged clinical benefits suggest EECP could be a regenerative therapy. This study was performed to determine whether EECP increased circulating hematopoietic progenitor cells (HPCs) or endothelial progenitor cells (EPCs) and thus be a possible regenerative therapy. The proposed mechanism of the increase in regenerative circulating stem cells is the enhanced shear forces induced on the endothelial boundary by the flow reversal produced by the sequential inflation of the pneumatic cuffs during EECP therapy. PMID:20036860

Jewell, Coty W; Houck, Philip D; Watson, Linley E; Dostal, David E; Dehmer, Gregory J

2010-01-01

87

Extracellular, stem cells and regenerative ophthalmology.  

PubMed

Retinal degenerative diseases, including retinitis pigmentosa, age-related macular degeneration, and glaucoma, still lack effective medical treatments. The stem cell-based regenerative approach has been proposed to treat these degenerative diseases. The major challenge for regenerative ophthalmology is to produce enough desirable retinal neurons in vitro from various stem cell types. Extracellular matrix proteins are important for stem cell self-renewal and differentiation in various systems. They have also been used in combination with various growth factors to expand retinal stem cells and produce desirable retinal neuronal types. This review summarizes our current understanding of how extracellular matrix proteins regulate stem cell function and discusses their application in regenerative ophthalmology. PMID:25275901

Wang, Yifeng; Xie, Ting

2014-01-01

88

Regenerative therapy: a periodontal-endodontic perspective.  

PubMed

Periodontal and endodontic diseases are inflammatory responses leading to periodontal and pulpal tissue loss. Regenerative therapies aim to restore the lost structures to vitality and function. Various materials and treatments methods have been used such as bone grafts, guided tissue regeneration, enamel matrix derivatives, growth and differentiation factors, and stem cells. Although the current materials and methods demonstrated adequate clinical results, true and complete biological tissue regeneration is not yet attainable. The current article reviews chronologically the materials and methods used in periodontal and endodontic regeneration highlighting their clinical success and shortcomings, and discussing future directions in regenerative therapy. PMID:22835536

Kinaia, Bassam Michael; Chogle, Sami M A; Kinaia, Atheel M; Goodis, Harold E

2012-07-01

89

Cell sheets engineering for esophageal regenerative medicine  

PubMed Central

Recently, cell-based therapies, regenerative medicine, and tissue engineering have been progressing rapidly. We have developed a novel strategy for regenerative medicine to recover tissue functions using temperature-responsive cell culture surfaces. To overcome of conventional methods such as the usage of single-cell suspension injection, we have applied transplantable cell sheets fabricated with temperature-responsive culture surfaces for cell delivery. In the field of gastroenterology, transplantable cell sheets from autologous oral mucosal epithelial cells can prevent esophageal stricture following extensive endoscopic mucosal resection.

Kanai, Nobuo; Yamato, Masayuki

2014-01-01

90

Problems in the Differential Diagnosis of Endometrial Hyperplasia and Carcinoma  

Microsoft Academic Search

The differential diagnosis of endometrial hyperplasia and well-differentiated endometrioid adenocarcinoma is complicated not only by the resemblance of these lesions to each other, but also by their tendency to be overdiagnosed (particularly hyperplasia) on the background of polyps, endometritis, artifacts, and even normally cycling endometrium. Atypical hyperplasia may also be overdiagnosed when epithelial metaplastic changes occur in simple or complex

Steven G. Silverberg

2000-01-01

91

Laser application of the benign prostatic hyperplasia  

Microsoft Academic Search

Summary form only given. Most urologists still think that a fundamental treatment method for the BPH (benign prostatic hyperplasia) is the TUR (transurethral resection). However, a group of urologists and medical engineers have developed a variety of equipment that were designed to cover the demerits of the TUR based on the concept of thermotherapy. Though much of the equipment has

Sung Won Kwon

1999-01-01

92

Laser treatment of symptomatic benign prostatic hyperplasia  

Microsoft Academic Search

The treatment of lower urinary symptoms secondary to benign prostatic hyperplasia (BPH) after failure of medical therapies remains controversial for most urologic surgeons. The complications of traditional surgery are the driving force behind the development of several minimally invasive treatments of symptomatic BPH. Laser prostatectomy is one of the most investigated such modalities. In this article we reviewed the results

Ehab A. Elzayat; Mostafa M. Elhilali

2006-01-01

93

Cutaneous lymphoid hyperplasia: results of radiation therapy  

SciTech Connect

Four cases of cutaneous lymphoid hyperplasia (CLH) were treated with radiation therapy. Sixteen separate areas of the skin were irradiated. Only two received more than 18 Gy (1800 rad). Follow-up ranged from eight months to seven years. No infield recurrences were observed, and cosmetic results were excellent. The authors suggest that radiation therapy can be highly effective in the treatment of CLH.

Olson, L.E.; Wilson, J.F.; Cox, J.D.

1985-05-01

94

Hormonal manipulation of benign prostatic hyperplasia  

Microsoft Academic Search

PURPOSE OF REVIEW: We provide new viewpoints of hormonal control of benign prostatic hyperplasia (BPH). The latest treatment findings with 5-alpha reductase inhibitors (5-ARIs) finasteride and dutasteride, refined indications, efficacy, and safety are discussed and compared. We also discuss potential new 5-ARIs and other hormonal treatments. RECENT FINDINGS: Finasteride and dutasteride have equal efficacy and safety for the treatment and

F. G. Rick; S. H. Saadat; L. Szalontay; N. L. Block; A. Kazzazi; B. Djavan; A. V. Schally

2013-01-01

95

Neointimal hyperplasia associated with synthetic hemodialysis grafts  

Microsoft Academic Search

Stenosis is a major cause of failure of hemodialysis vascular grafts and is primarily caused by neointimal hyperplasia (NH) at the anastomoses. The objective of this article is to provide a scientific review of the biology underlying this disorder and a critical review of the state-of-the-art investigational preventive strategies in order to stimulate further research in this exciting area. The

Li Li; Christi M Terry; Yan-Ting E Shiu; Alfred K Cheung

2008-01-01

96

REGEN AGENT: A MODULAR AND GENERALIZED FOREST REGENERATION AGENT  

Microsoft Academic Search

This thesis describes the implementation of two software applications: REGEN Agent and REGEN Agent for Excel. REGEN Agent is an expert system and modeling application providing a mechanism for forest regeneration prediction based on the Loftis regeneration model. The Loftis model is both a stochastic and a competitive model that utilizes expert knowledge encoded in a knowledge base and applies

DAVID AGUSTIN BOUCUGNANI

97

Energy Management for Regenerative Brakes on a DC Feeding System  

Microsoft Academic Search

Recently, regenerative brakes are implemented in trains at DC fed electric railways in Japan. Regenerative braking system converts kinetic energy to electrical energy. And other powering trains at the identical feeding circuit must consume the electrical energy. Therefore, when the electrical loads are not sufficient at feeding circuit, braking trains must squeeze regenerative power. The problem is that such braking

Yuruki Okada; Takafumi Koseki; Satoru Sone

98

An improved theory for regenerative pump performance  

E-print Network

, impeller angles, CFD 1 INTRODUCTION Regenerative flow pumps and compressors have found many applications for the pump performance. The model can handle one inlet angle and two exit angles for the impeller blades and it can be used for the design of twisted blades that would increase the pump head and efficiency. A new

Kim, Yong Jung

99

Regenerative fuel cells for space applications  

NASA Technical Reports Server (NTRS)

After several years of development of the regenerative fuel cell (RFC) as the electrochemical storage system to be carried by the future space station, the official stance has now been adopted that nickel hydrogen batteries would be a better system choice. RFCs are compared with nickel hydrogen and other battery systems for space platform applications.

Appleby, A. John

1987-01-01

100

Regenerative Studies: College Community and Community College.  

ERIC Educational Resources Information Center

This case study applies principles derived from the Center for Regenerative Studies (CRS) to a community college in North Carolina. CRS, on the campus of California State Polytechnic Institute (California), is dedicated to the education, demonstration, and research of degenerative systems in the areas of shelter, food production, energy, water and…

Woltz, Mary G.

101

April 2011 1 Regenerative Fuel Cells  

E-print Network

;April 2011 5 Issues Motivating WaMM Development ­ Unitized Regenerative Fuel Cell: · Could save volume at lower pressure/high recirculation rates to remove water. ­ Complicated in low gravity ­ Parasitic is Becoming Competitive Table 1 COSTS OF HYDROGEN FROM PEM ELECTROLYSIS Based on US Department o

102

Use of elastomers in regenerative braking systems  

NASA Astrophysics Data System (ADS)

The storage of potential energy as strain energy in elastomers was investigated. The evolution of the preferred stressing scheme is described, and test results on full-size elastomeric energy storage units sized for an automotive regenerative braking system application are presented. The need for elastomeric material improvements is also discussed.

103

Coordinated control for regenerative braking system  

Microsoft Academic Search

This paper presents a design of regenerative braking system (RBS) for hybrid electric vehicles using hierarchical control structure and method. The hierarchical model is mainly composed of three modules for driver intent identification, energy management and coordinated control based on components control. As a consequence, RBS, a complicated hybrid dynamic system, is successfully decomposed by several simple modules. The control

Zhang Junzhi; Lu Xin; Chen Shanglou; Zhang Pengjun

2008-01-01

104

Cutting vehicle emissions with regenerative braking  

Microsoft Academic Search

This paper presents an analysis of vehicle regenerative braking systems as a quick and relatively easy means of achieving higher overall fuel efficiency and lowering carbon emissions. The system involves the installation of an additional electric motor\\/generator in parallel to the vehicle’s internal combustion engine and is used in conjunction with a DCDC converter and ultracapacitor. The system is used

Peter Clarke; Tariq Muneer; Kevin Cullinane

2010-01-01

105

Modeling regenerative braking and storage for vehicles  

Microsoft Academic Search

The fuel saving benefits of regenerative braking and storage for vehicles are often described but not quantified. For example, the federal government and automobile manufacturers are sponsoring a Program for a New Generation of Vehicles (PGNV) with a goal of obtaining a performance of 80 mpg in a family size car. It is typically suggested that such a vehicle will

F. Wicks; K. Donnelly

1997-01-01

106

Regenerative nanomedicine: current perspectives and future directions  

PubMed Central

Nanotechnology has considerably accelerated the growth of regenerative medicine in recent years. Application of nanotechnology in regenerative medicine has revolutionized the designing of grafts and scaffolds which has resulted in new grafts/scaffold systems having significantly enhanced cellular and tissue regenerative properties. Since the cell–cell and cell-matrix interaction in biological systems takes place at the nanoscale level, the application of nanotechnology gives an edge in modifying the cellular function and/or matrix function in a more desired way to mimic the native tissue/organ. In this review, we focus on the nanotechnology-based recent advances and trends in regenerative medicine and discussed under individual organ systems including bone, cartilage, nerve, skin, teeth, myocardium, liver and eye. Recent studies that are related to the design of various types of nanostructured scaffolds and incorporation of nanomaterials into the matrices are reported. We have also documented reports where these materials and matrices have been compared for their better biocompatibility and efficacy in supporting the damaged tissue. In addition to the recent developments, future directions and possible challenges in translating the findings from bench to bedside are outlined. PMID:25214780

Chaudhury, Koel; Kumar, Vishu; Kandasamy, Jayaprakash; RoyChoudhury, Sourav

2014-01-01

107

Hepatic adenoma and focal nodular hyperplasia.  

PubMed

Hepatic adenoma and focal nodular hyperplasia are benign lesions of the liver. The incidence of these conditions has been increasing since 1970. Hepatic adenoma primarily affects young women of childbearing age who have a long history of using oral contraceptives, while focal nodular hyperplasia has a wider age distribution and is not associated with the use of oral contraceptives. The most extensive complication of hepatic adenoma is intratumoral or intraperitoneal hemorrhage, which occurs in 50 to 60 per cent of patients. Patients with focal nodular hyperplasia are usually asymptomatic and rarely experience complications. Hepatic adenoma is distinct from focal nodular hyperplasia both in its clinical behavior and its pathologic features; the two can usually be differentiated radiographically using a combination of radionuclide scanning and angiography. There is a proved association between the use of oral contraceptives and the development of hepatic adenoma; the longer the duration of oral contraceptive use, the more the risk of having hepatic adenoma develop. In addition, users of oral contraceptives who have hepatic adenoma develop are likely to have larger tumors and higher rates of bleeding and rupture than nonusers who have hepatic adenoma develop. Although hepatic adenomas may regress after discontinuation of oral contraceptive use, this is not a consistent finding. In addition, it has now been demonstrated that hepatic adenomas do undergo malignant transformation and that this can be detected by measuring the alpha-fetoprotein level. Focal nodular hyperplasia may be a precursor for fibrolamellar hepatocellular carcinoma. Elective resection of hepatic adenoma has a mortality rate of less than 1 per cent, while the mortality rate with free rupture is 5 to 10 per cent. Because of the relative safety of elective versus emergency resection and the potential for malignant change, the treatment of choice for hepatic adenoma is surgical resection. PMID:1658955

Shortell, C K; Schwartz, S I

1991-11-01

108

[Pikamilone treatment of benign prostatic hyperplasia].  

PubMed

Pikamilone is an original drug of Russian produce having a central (vegetotropic and vascular) and peripheral (vasodilating) mechanisms of action. The drug was tried as monotherapy in elderly patients with benign prostatic hyperplasia who had symptoms of the lower urinary tracts to estimate its effect on local and general mechanisms of nervous and vascular regulation of detruzor function in infravesical obstruction. A positive trend in the clinical symptoms was observed (by IPSS scale), especially irritative symptoms. Urodynamics has also improved: maximal and mean urinary flow rate and total amount of urination increased. However, the residual urine volume remained the same. Further placebo-controlled and randomized studies are needed for precise estimation of pikamilone effects. Meanwhile, the drug can be used as a component of combined therapy of benign prostatic hyperplasia. PMID:11150159

Tolstova, S S

1999-01-01

109

New Treatments for Benign Prostatic Hyperplasia  

PubMed Central

Benign prostatic hyperplasia is the most common of all neoplasms. The most common treatment is prostatectomy, but other available therapies include androgen antagonists, ?-adrenergic blockers, anticholinergic agents, prostate dilation with a ballon, and urethral stents. Prostatectomy is likely to remain the standard of care for the foreseeable future because it is safe and much more effective than all other current and experimental forms of therapy. PMID:21229073

Skepasts, Peter K.; Lee, Laurence M.

1991-01-01

110

Laser treatment of benign prostatic hyperplasia  

Microsoft Academic Search

To evaluate the role of lasers that allow acute removal of obstructing tissue in the surgical treatment of benign prostatic\\u000a hyperplasia (BPH). A MEDLINE search over the last 6 years focused on randomized trials, large case series and review articles.\\u000a A total of more than 4,000 patients were analyzed with respect to the morbidity and outcome, and the advantages and disadvantages

Rainer M. Kuntz

2007-01-01

111

[Steroid balance in patients with breast hyperplasia].  

PubMed

A correlation was found between the character of hormonal disorders and the morphological organization of dyshormonal hyperplasias of the mammary gland. Patients with fibroadenoma and fibrous-cystic mastopathy are characterized by a high diurnal urine content of glucocorticoids and low estrogens level, especially estradiol. Patients with cystic fibroadenomatosis of the mammary gland show the high level of the excretion of classical and total phenolsteroids and low androsterone level. PMID:695432

Samundzhan, E M; Gorevaia, A N; Kartavova, N S; Makarchuk, N M; Nekrasov, P Ia

1978-01-01

112

Combined Adrenal Myelolipoma and Medullary Hyperplasia  

Microsoft Academic Search

Objective: A patient is reported with hypertension due to combined medullary adrenal hyperplasia and myelolipoma. Methods: A 52-year-old woman with long-standing hypertension was evaluated for an incidentally discoveredlargetumor of the left adrenal. Left adrenalectomy was performed for a presumptive clinical diagnosis of pheochromocytoma. Results: Histopathologic examination revealed a mixed tumor consisting of a large myelolipoma with infiltrating foci of adrenal

Avraham Ishay; Muralee Dharan; Rafael Luboshitzky

2004-01-01

113

Translational strategies and challenges in regenerative medicine.  

PubMed

The scientific community is currently witnessing substantial strides in understanding stem cell biology in humans; however, major disappointments in translating this knowledge into medical therapies are flooding the field as well. Despite these setbacks, investigators are determined to better understand the caveats of regeneration, so that major pathways of repair and regrowth can be exploited in treating aged and diseased tissues. Last year, in an effort to contribute to this burgeoning field, Nature Medicine, in collaboration with the Volkswagen Foundation, organized a meeting with a panel of experts in regenerative medicine to identify the most pressing challenges, as well as the crucial strategies and stem cell concepts that can best help advance the translational regenerative field. Here some experts who participated in the meeting provide an outlook at some of those key issues and concepts. PMID:25100527

Dimmeler, Stefanie; Ding, Sheng; Rando, Thomas A; Trounson, Alan

2014-08-01

114

Micro-Scale Regenerative Heat Exchanger  

NASA Technical Reports Server (NTRS)

A micro-scale regenerative heat exchanger has been designed, optimized and fabricated for use in a micro-Stirling device. Novel design and fabrication techniques enabled the minimization of axial heat conduction losses and pressure drop, while maximizing thermal regenerative performance. The fabricated prototype is comprised of ten separate assembled layers of alternating metal-dielectric composite. Each layer is offset to minimize conduction losses and maximize heat transfer by boundary layer disruption. A grating pattern of 100 micron square non-contiguous flow passages were formed with a nominal 20 micron wall thickness, and an overall assembled ten-layer thickness of 900 microns. Application of the micro heat exchanger is envisioned in the areas of micro-refrigerators/coolers, micropower devices, and micro-fluidic devices.

Moran, Matthew E.; Stelter, Stephan; Stelter, Manfred

2004-01-01

115

An analytical model for regenerative refrigerators  

NASA Astrophysics Data System (ADS)

An analytical model for regenerative refrigerators is given. The model has two main features: (1) establish the models of parts, including regenerator, heat exchanger, working volume, etc., individually, then, relate all parts by the boundary conditions. (2) the equation of model is reduced to a set of linear algebraic equations. In the model, the interaction of all parts, the cyclic flow and heat transfer of regenerators and heat exchangers and limited heat transfer of working volumes, effect of real gas, etc, are considered simultaneously. In addition, the numerical results of a Vuilleumier refrigerator with power being supplied by liquid nitrogen are compared with the Schmidt model and the experimental results. The model provides a better understanding of the working mechanism of regenerative refrigerators.

Jian-Feng, Wu; Yuan, Zhou

116

Theory of an active magnetic regenerative refrigerator  

SciTech Connect

The adiabatic temperature change with field is limited to about 2 K/Tesla for ferromagnets near their Curie temperatures by the change of magnetization with temperature and the lattice heat capacity. Hence, practical magnetic refrigerators operate on a regenerative cycle such as the Brayton cycle. One way to execute this cycle is through the use of an active magnetic regenerator, i.e. a regenerator composed of magnetic material that is cycled in an out of a magnetic field with appropriate fluid flows. The theory of these devices can be predicted by solving the partial differential equations that describe fluid and the magnetic solid. The active magnetic regenerator is described along with the method of calculation. Temperature profiles for a normal regenerator and a magnetic regenerative refrigerator are shown.

Barclay, J.A.

1982-01-01

117

Regenerative nanomedicines: an emerging investment prospective?  

PubMed

Cells respond to their structural surrounding and within nanostructures exhibit unique proliferative and differentiation properties. The application of nanotechnologies to the field of regenerative medicine offers the potential to direct cell fate, target the delivery of cells and reduce immune rejection (via encapsulation), thereby supporting the development of regenerative medicines. The overall objective of any therapy is the delivery of the product not just into the clinic but also to patients on a routine basis. Such a goal typically requires a commercial vehicle and substantial levels of investment in scientific, clinical, regulatory and business expertise, resources, time and funding. Therefore, this paper focuses on some of the challenges facing this emerging industry, including investment by the venture capital community. PMID:20826478

Prescott, Catherine

2010-12-01

118

Endometrial stem cells in regenerative medicine  

PubMed Central

First described in 2004, endometrial stem cells (EnSCs) are adult stem cells isolated from the endometrial tissue. EnSCs comprise of a population of epithelial stem cells, mesenchymal stem cells, and side population stem cells. When secreted in the menstrual blood, they are termed menstrual stem cells or endometrial regenerative cells. Mounting evidence suggests that EnSCs can be utilized in regenerative medicine. EnSCs can be used as immuno-modulatory agents to attenuate inflammation, are implicated in angiogenesis and vascularization during tissue regeneration, and can also be reprogrammed into induced pluripotent stem cells. Furthermore, EnSCs can be used in tissue engineering applications and there are several clinical trials currently in place to ascertain the therapeutic potential of EnSCs. This review highlights the progress made in EnSC research, describing their mesodermal, ectodermal, and endodermal potentials both in vitro and in vivo. PMID:25097665

2014-01-01

119

A solar regenerative thermoelectrochemical converter (RTEC)  

SciTech Connect

This is an executive summary of a final subcontract report that describes the successful completion of a closed-loop demonstration of a regenerative thermoelectromechanical device using solar heat input for the production of electricity. The full report, which contains a detailed description of the two-year effort, is currently subject to a government secrecy order which precludes public release of the information. Copies of the full report will be made available for general release whenever the secrecy order is lifted.

Townsend, C.W.; McHardy, J. (Hughes Aircraft Co., El Segundo, CA (United States))

1992-02-01

120

Secular Humanist Bioethics and Regenerative Medicine  

Microsoft Academic Search

\\u000a As Daniel Callahan perceptively observed some 20 years ago, issues and dilemmas in bioethics might be new as a result of remarkable\\u000a advances in biomedical science, but the moral questions they raise are “among the oldest that human beings have asked themselves”\\u000a (Callahan, 2004, p. 278). Regenerative Medicine is a cutting edge medicine, devoted to the repair of damaged, diseased,

Ping-Cheung Lo

121

Low-temperature thermally regenerative electrochemical system  

DOEpatents

A thermally regenerative electrochemical system is described including an electrochemical cell with two water-based electrolytes separated by an ion exchange membrane, at least one of the electrolytes containing a complexing agent and a salt of a multivalent metal whose respective order of potentials for a pair of its redox couples is reversible by a change in the amount of the ocmplexing agent in the electrolyte, the complexing agent being removable by distillation to cause the reversal.

Loutfy, R.O.; Brown, A.P.; Yao, N.P.

1982-04-21

122

Common ethical issues in regenerative medicine.  

PubMed

One of the common ethical issues in regenerative medicine is progress in 'componentation' (= being treated as parts) of the human body, and the enhancement of the view of such "human body parts." 'Componentation' of the human body represents a preliminary step toward commodification of the human body. The process of commodification of the human body follows the steps of 'materialization' (= being treated as a material object) [first step] -- 'componentation' [second step] -- 'resourcialization' (= being treated as resources) [third step] -- commodification [fourth step]. Transplantation medicine and artificial organ developments have dramatically exposed the potential of organs and tissues as parts, and regenerative medicine has a role in advancing 'componentation' of the human body and further enhancing the view of human body parts. The 'componentation' of the human body, regardless of the degree of regenerative medicine's contribution to it, is considered as a challenge to the traditional view of human bodies and the abstract value of "Human Dignity" in the same way or alongside the 'resourcialization' and commodification. However, in the future, a new perspective of human bodies that means "a perspective whereby human bodies, organs, tissues, and even the bodies themselves are perceived as disposable tools like disposable cameras, syringes, or contact lens" and therefore a new ethical view, suitable for a new reality, may emerge. PMID:16637131

Awaya, Tsuyoshi

2005-01-01

123

Allogenicity & immunogenicity in regenerative stem cell therapy  

PubMed Central

The development of regenerative medicine relies in part on the capacity of stem cells to differentiate into specialized cell types and reconstitute tissues and organs. The origin of the stem cells matters. While autologous cells were initially the preferred ones the need for “off the shelf” cells is becoming prevalent. These cells will be immediately available and they originate from young non diseased individuals. However their allogenicity can be viewed as a limitation to their use. Recent works including our own show that allogenicity of stem cell can be viewed as on one hand detrimental leading to their elimination and on the other hand beneficial through a paracrine effect that can induce a local tissue regenerative effect from endogenous stem cells. Also their immune modulatory capacity can be harnessed to favor regeneration. Therefore the immune phenotype of stem cells is an important criteria to be considered before their clinical use. Immuno monitoring of the consequences of their in vivo injection needs to be taken into account. Transplantation immunology knowledge will be instrumental to enable the development of safe personalized regenerative stem cell therapy. PMID:24434327

Charron, Dominique

2013-01-01

124

Unilateral condylar hyperplasia: A case report and review of literature  

PubMed Central

Condylar hyperplasia is (CH) an uncommon malformation of the mandible involving change in size and morphology of the condylar neck and head. CH is an anomaly that usually occurs unilaterally and equally affects in both men and women. Hyperplasia of the condyle ‘differentiated into hemimandibular hyperplasia, hemimandibular elongation and CH. Here, we are presenting a case of 17-year-old male patient with unilateral CH and its review of the literature. PMID:24818099

Bharathi, Saravana C.; Senthilnathan, S.; Kumar, Lokesh D.; Mohan, Anand C. S.; Taranath, M.

2014-01-01

125

Regenerative Braking Algorithm for a HEV with CVT Ratio Control During Deceleration  

Microsoft Academic Search

A regenerative braking algorithm is proposed to make maximum use of regenerative brake for improvement of fuel consumption. In the regenerative braking algorithm, the regenerative torque is determined by considering the motor capacity, battery SOC and vehicle velocity. The regenerative braking force is calculated from the brake control unit by comparing the demanded brake force(torque) and the motor torque available.

Hoon Yeo; Donghyun Kim; Sungho Hwang; Hyunsoo Kim

126

Two-photon polymerization microstructuring in regenerative medicine.  

PubMed

Two-photon polymerization has developed as a powerful tool for making micro- and nanoscale structures for regenerative medicine applications. This review discusses micro- and nanoscale aspects of tissue engineering, which are followed by a brief description of the two-photon polymerization process and how it has been used thus far in tissue engineering and other regenerative medicine applications. Lastly, potential future applications of two-photon polymerization in regenerative medicine are presented. This review provides a comprehensive summary of the uses of two-photon polymerization thus far in regenerative medicine and a look into how this technique will be used in the future. PMID:23277016

Gittard, Shaun Davis; Koroleva, Anastasia; Nguyen, Alexander Khoa; Fadeeva, Elena; Gaidukeviciute, Arune; Schlie-Wolter, Sabrina; Narayan, Roger Jagdish; Chichkov, Boris

2013-01-01

127

The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine  

E-print Network

Biomechanical factors profoundly influence the processes of tissue growth, development, maintenance, degeneration, and repair. Regenerative strategies to restore damaged or diseased tissues in vivo and create living tissue ...

Butler, David L.

128

Prostate . Author manuscript Inflammation in benign prostatic hyperplasia: a 282 patients'  

E-print Network

Prostate . Author manuscript Page /1 7 Inflammation in benign prostatic hyperplasia: a 282 patients be a key component in prostate enlargement and benign prostatic hyperplasia (BPH) progression. Our aim Analysis ; Middle Aged ; Prostatic Hyperplasia ; complications ; pathology ; Prostatitis ; complications

Boyer, Edmond

129

Rebouissou et al 1 Molecular pathogenesis of focal nodular hyperplasia and  

E-print Network

Rebouissou et al 1 Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma@cephb.fr Key Words: Hepatocellular adenoma, focal nodular hyperplasia, chromosome, gene mutation, hepatocyte adenomatous polyposis coli) FNH (focal nodular hyperplasia) HCA (hepatocellular adenoma) HCC (hepatocellular

Paris-Sud XI, Université de

130

Syringolymphoid hyperplasia with alopecia. A case report.  

PubMed

Syringolymphoid hyperplasia with alopecia is an uncommon skin disorder described in 1969 by Sarkany. Since then only three additional cases have been reported, all in the European literature. We present a 59-year-old man with two persistent hyperpigmented hairless patches of 13 years duration. Biopsy specimens revealed characteristic hyperplastic changes of the eccrine glands and ducts and a dense lymphocytic infiltrate surrounding eccrine structures with "syringotropism". Perifollicular lymphocytic infiltration and changes consistent with follicular mucinosis and mycosis fungoides were also present. Imunophenotyping and gene rearrangement studies showed the cells to be primarily of the T helper phenotype with rearrangement of the surface receptor gene. PMID:7699119

Tomaszewski, M M; Lupton, G P; Krishnan, J; Welch, M; James, W D

1994-12-01

131

Transpiration And Regenerative Cooling Of Rocket Engine  

NASA Technical Reports Server (NTRS)

Transpiration cooling extends limits of performance. Addition of transpiration cooling to regeneratively-cooled rocket-engine combustion chamber proposed. Modification improves performance of engine by allowing use of higher chamber pressure. Throat section of combustion-chamber wall cooled by transpiration, while chamber and nozzle sections cooled by fluid flowing in closed channels. Concept applicable to advanced, high-performance terrestrial engines or some kinds of industrial combustion chambers. With proper design, cooling scheme makes possible to achieve higher chamber pressure and higher overall performance in smaller engine.

Obrien, Charles J.

1989-01-01

132

78 FR 43889 - Synergizing Efforts in Standards Development for Cellular Therapies and Regenerative Medicine...  

Federal Register 2010, 2011, 2012, 2013

...Standards Development for Cellular Therapies and Regenerative Medicine Products...activities involving cellular therapies and regenerative medicine products...workshop will be provided on a space available basis beginning at...clinical development of cellular therapies and regenerative medicine...

2013-07-22

133

Clinical and Imaging Findings of True Hemifacial Hyperplasia  

PubMed Central

Congenital hemifacial hyperplasia is a rare developmental disorder of unknown etiology, characterized by a marked unilateral facial asymmetry. It involves the hard (bones and teeth) and soft tissues of the face. We report an interesting case of true hemifacial hyperplasia in a 25-year-old male highlighting the clinical and computed tomography imaging findings. PMID:24349801

Bhuta, Bansari A.; Desai, Rajiv S.; Bansal, Shivani P.; Chemburkar, Vipul V.; Dev, Prashant V.

2013-01-01

134

Cyclooxygenase 2 Promotes Parathyroid Hyperplasia in ESRD  

PubMed Central

Hyperplasia of the PTG underlies the secondary hyperparathyroidism (SHPT) observed in CKD, but the mechanism underlying this hyperplasia is incompletely understood. Because aberrant cyclooxygenase 2 (COX2) expression promotes epithelial cell proliferation, we examined the effects of COX2 on the parathyroid gland in uremia. In patients with ESRD who underwent parathyroidectomy, clusters of cells within the parathyroid glands had increased COX2 expression. Some COX2-positive cells exhibited two nuclei, consistent with proliferation. Furthermore, nearly 78% of COX2-positive cells expressed proliferating cell nuclear antigen (PCNA). In the 5/6-nephrectomy rat model, rats fed a high-phosphate diet had significantly higher serum PTH levels and larger parathyroid glands than sham-operated rats. Compared with controls, the parathyroid glands of uremic rats exhibited more PCNA-positive cells and greater COX2 expression in the chief cells. Treatment with COX2 inhibitor celecoxib significantly reduced PCNA expression, attenuated serum PTH levels, and reduced the size of the glands. In conclusion, COX2 promotes the pathogenesis of hyperparathyroidism in ESRD, suggesting that inhibiting the COX2 pathway could be a potential therapeutic target. PMID:21335517

Zhang, Qian; Qiu, Junsi; Li, Haiming; Lu, Yanwen; Wang, Xiaoyun; Yang, Junwei; Wang, Shaoqing; Zhang, Liyin; Gu, Yong; Hao, Chuan-Ming

2011-01-01

135

Intrahepatic bile duct injury and nodular regenerative hyperplasia of the liver in a patient with polyarteritis nodosa  

Microsoft Academic Search

Although involvement of the hepatic vasculture in patients with polyarteritis nodosa is not unusual, biliary manifestations are very rare. We describe a patient with polyarteritis nodosa presenting with a febrile cholestatic anicteric syndrome. Histological examination of the liver revealed necrotizing arteritis of small hepatic arteries associated with significant lesions of intrahepatic bile ducts of the sclerosing cholangitis type, i.e. fibrous

Constantin P. Goritsas; Maria Repanti; Eleni Papadaki; Nikolaos Lazarou; Andrew P. Andonopoulos

1997-01-01

136

Myeloid hyperplasia in the SENCAR mouse: differentiation from granulocytic leukemia  

SciTech Connect

The term myeloid hyperplasia has been used interchangeably with many other terms to describe an increased production of granulocytes, megakaryocytes, and erythrocytes in the spleen and other organs in the mouse. This process is occasionally misdiagnosed as granulocytic leukemia. This paper reviews some of the terms used interchangeably with myeloid hyperplasia and describes criteria that can be used to differentiate myeloid hyperplasia from granulocytic leukemia. Additionally, the results of a study in which myeloid hyperplasia was induced following the formation of skin tumors in SENCAR mice is discussed. In this study, positive correlations were found between skin lesions, the spleen weight, and histologic appearance of the spleen. The liver rarely showed microscopic changes of myeloid hyperplasia unless the spleen weighed at least 1.0% of the body weight.

Long, R.E.; Knutsen, G.; Robinson, M.

1986-09-01

137

Integrated regenerative fuel cell experimental evaluation  

NASA Technical Reports Server (NTRS)

An experimental test program was conducted to investigate the performance characteristics of an integrated regenerative fuel cell (IRFC) concept. The IRFC consists of a separate fuel cell unit and electrolysis cell unit in the same structure, with internal storage of fuel cell product water and external storage of electrolysis cell produced hydrogen and oxygen. The fuel cell unit incorporates an enhanced Orbiter-type cell capable of improved performance at reduced weight. The electrolysis cell features a NiCo2O4 catalyst oxygen evolution eletrode with a porous Teflon cover to retard electrolyte loss. Six complete IRFC assemblies were assembled and performance tested at an operating temperature of 200 F (93.3 C) and reactant pressures up to 170 psia (117.2 n/cu cm) on IRFC No. 4. Anomalous pressure charge/discharge characteristics were encountered during performance evaluation. A reversible fuel cell incorporating a proprietary bi-functional oxygen electrode operated satisfactory at 200 F (93.3 C) at reactant pressures up to 50 psia (41.4 n/cu cm) as a regenerative fuel cell for one cycle, before developing an electrical short in the fuel cell mode. Electrolysis cell 300-hour endurance tests demonstrated the electrolyte retention capability of the electrode Teflon cover and the performance stability of the bi-functional oxygen electrode at high potential.

Martin, Ronald E.

1990-01-01

138

Regenerative Potential of the Zebrafish Corneal Endothelium  

PubMed Central

Corneal transparency, critical for clear vision, is maintained in part by the pump function of the corneal endothelial cells that are arrested in G1 phase of the cell cycle in adult humans. Thus loss of endothelial cells leads to a decrease in endothelial cell density. A decrease below a critical threshold results in corneal edema and subsequent vision loss. Corneal edema due to endothelial dysfunction is a common indication for transplantation in developed countries. The zebrafish has emerged as a model for vertebrate regeneration due to its ease of genetic manipulation and remarkable regenerative capacity. The purpose of this study was to investigate the response and regenerative potential of the zebrafish corneal endothelium to pharmacological and mechanical injury. Similar to the human cornea, Na+/K+ ATPase activity is necessary to maintain the pump function as intracameral injection of ouabain resulted in an increase in central corneal thickness. Surgical removal of the majority of the central corneal endothelium resulted in a similar increase in corneal thickness. Remarkably, by just one week post-injury the central corneal endothelium had largely re-formed. Immunofluorescence of phosphorylated histone H3 indicated that this recovery correlated with corneal endothelial cells re-entering the cell cycle. In conclusion, our results establish zebrafish as a useful model of corneal injury and repair that may offer insights into the mechanism of cell cycle arrest in human corneal endothelial cells. PMID:23108006

Heur, Martin; Jiao, Shuliang; Schindler, Simone; Crump, J. Gage

2012-01-01

139

Erich Regener - a forgotten cosmic ray pioneer  

NASA Astrophysics Data System (ADS)

In the 1930s the German physicist Erich Regener (1881-1955), did important work on the measurement of the rate production of ionisation in the atmosphere and deep under-water. He discovered, along with one of his students, Georg Pfotzer, the altitude at which the production of ionisation in the atmosphere reaches a maximum, often and misleadingly called the Pfotzer maximum. He was one of the first to estimate the energy density of cosmic rays, an estimate used by Baade and Zwicky to postulate that supernovae might be the source of cosmic rays. Yet Regener's name is little known largely because he was forced to take early retirement by the National Socialists in 1937 as his wife had Jewish ancestors. In this paper we review his work on cosmic rays and the subsequent influence that he had on the subject through his son, his son-in-law, his grandson and his students. He was nominated for the Nobel Prize in Physics by Schroedinger in 1938. He died in 1955 at the age of 73.

Carlson, Per; Watson, Alan

2013-04-01

140

Bioethical aspects of regenerative and reproductive medicine.  

PubMed

The birth announced in 1997 of Dolly, the lamb cloned from the somatic mammary cells of an adult ewe, and the discovery of human embryonic stem cells in 1998 have been the most exciting developments in the biological sciences in the past decade. Reproductive somatic cell nuclear transfer (SCNT) in additional species has been inefficient in that relatively few births, harmful side effects and high fetal and neonatal death rates have resulted from many attempts. Ongoing debates about the ethics of reproductive SCNT have revealed that some researchers regard human reproductive SCNT as morally unacceptable in all circumstances, others see merit in reproductive SCNT in certain circumstances and others await more information before making judgment about the ethical status of the procedure. Regenerative medicine and emerging biotechnologies started to revolutionize the practice of medicine. Advances in stem cell biology, including embryonic and postnatal somatic stem cells, have made the prospect of tissue regeneration a potential reality. Mammal cloning experiments have provided new impetus to the prospect of regenerative medicine through stem cell research. The procedure of SCNT could be used to create the raw material to replace defective or senescent tissue as a natural extension of the biology of stem cells. Researchers working in reproductive medicine should consider the potential hope given to many patients against the requisite and ethically contentious creation of human blastocysts for therapeutic intent. PMID:16879561

Yoshimura, Yasunori

2006-05-01

141

Multiple excitation regenerative amplifier inertial confinement system  

DOEpatents

The invention relates to apparatus and methods for producing high intensity laser radiation generation which is achieved through an optical amplifier-storage ring design. One or two synchronized, counterpropagating laser pulses are injected into a regenerative amplifier cavity and amplified by gain media which are pumped repetitively by electrical or optical means. The gain media excitation pulses are tailored to efficiently amplify the laser pulses during each transit. After the laser pulses have been amplified to the desired intensity level, they are either switched out of the cavity by some switch means, as for example an electro-optical device, for any well known laser end uses, or a target means may be injected into the regenerative amplifier cavity in such a way as to intercept simultaneously the counterpropagating laser pulses. One such well known end uses to which this invention is intended is for production of high density and temperature plasmas suitable for generating neutrons, ions and x-rays and for studying matter heated by high intensity laser radiation.

George, Victor E. [Livermore, CA; Haas, Roger A. [Pleasanton, CA; Krupke, William F. [Pleasanton, CA; Schlitt, Leland G. [Livermore, CA

1980-05-27

142

Multiple excitation regenerative amplifier inertial confinement system  

DOEpatents

The invention relates to apparatus and methods for producing high intensity laser radiation generation which is achieved through an optical amplifier-storage ring design. One or two synchronized, counterpropagating laser pulses are injected into a regenerative amplifier cavity and amplified by gain media which are pumped repetitively by electrical or optical means. The gain media excitation pulses are tailored to efficiently amplify the laser pulses during each transit. After the laser pulses have been amplified to the desired intensity level, they are either switched out of the cavity by some switch means, as for example an electro-optical device, for any well known laser end uses, or a target means may be injected into the regenerative amplifier cavity in such a way as to intercept simultaneously the counterpropagating laser pulses. One such well known end uses to which this invention is intended is for production of high density and temperature plasmas suitable for generating neutrons, ions and x-rays and for studying matter heated by high intensity laser radiation. 11 figs.

George, V.E.; Haas, R.A.; Krupke, W.F.; Schlitt, L.G.

1980-05-27

143

Advances in individualized and regenerative medicine.  

PubMed

Molecular and cell biology have resulted in major advances in our understanding of disease pathogenesis as well as in novel strategies for the diagnosis, therapy and prevention of human diseases. Based on modern molecular, genetic and biochemical methodologies it is on the one hand possible to identify for example disease-related point mutations and single nucleotide polymorphisms. On the other hand, using high throughput array and other technologies, it is for example possible to simultaneously analyze thousands of genes or gene products (RNA and proteins), resulting in an individual gene or gene expression profile ('signature'). Such data increasingly allow to define the individual disposition for a given disease and to predict disease prognosis as well as the efficacy of therapeutic strategies in the individual patient ('individualized medicine'). At the same time, the basic discoveries in cell biology, including embryonic and adult stem cells, induced pluripotent stem cells, genetically modified cells and others, have moved regenerative medicine into the center of biomedical research worldwide with a major translational impact on tissue engineering as well as transplantation medicine. All these aspects have greatly contributed to the recent advances in regenerative medicine and the development novel concepts for the treatment of many human diseases, including liver diseases. PMID:24797966

Blum, Hubert E

2014-03-01

144

Stem cells: intellectual property issues in regenerative medicine.  

PubMed

The topic of stem cells for use in regenerative medicine, especially embryonic stem cells, inspires much debate, discussion, and outrage as it slices through the very core moral values of society. These social and moral issues have, in turn, resulted in government policies that have influenced the study of stem cells in regenerative medicine. PMID:24304078

Zachariades, Nicholas A

2013-12-01

145

Energy savings in a building using regenerative evaporative cooling  

Microsoft Academic Search

This paper explores the potential of reducing the annual energy consumption of a central air-conditioned building through advanced evaporative cooling systems. The building considered is a typical three floor library building of a University. The regenerative evaporative cooling technology is coupled with the liquid cooled water chiller system to accomplish the energy conservation objective. Comparisons of the regenerative evaporative cooling

Ankur Khandelwal; Prabal Talukdar; Sanjeev Jain

2011-01-01

146

2013-2014 Handbook Stem Cell Biology and Regenerative  

E-print Network

. The SCBRM program is housed within the Lorry Lokey Stem Cell Research Building, a modern research facility2013-2014 Handbook Stem Cell Biology and Regenerative Medicine Interdisciplinary Graduate Program (PhD) #12;Institute for Stem Cell Biology and Regenerative Medicine Interdisciplinary Graduate Program

Puglisi, Joseph

147

Research on control for regenerative braking of electric vehicle  

Microsoft Academic Search

The limitation of driving range is the key restriction for the development of EV (electric vehicle), and regenerative braking is an effective approach to extend the driving range of electric vehicle. To protect the battery from broken caused by large charging current during regenerative braking, the control strategy that makes the charging current as control object is proposed in this

Binggang Cao; Zhifeng Bai; Wei Zhang

2005-01-01

148

Towards a regenerative paradigm for the built environment  

Microsoft Academic Search

The concept of regenerative design and development is situated within the broader theoretical context of sustainability. The emerging regenerative paradigm is contrasted with the two current sustainability paradigms – internationally negotiated ‘idealistic’ public policy and private sector ‘Ecological Modernization’ – that seek to maintain the status quo. Each of these sustainability paradigms is explained though a brief historical narrative to

Chrisna du Plessis

2012-01-01

149

Osteoinductive biomaterial geometries for bone regenerative engineering.  

PubMed

Worldwide, more than 2.2 million patients undergo bone graft procedures annually. In each of these procedures an interface is formed between the host tissue and the graft material. Synthetic implants exhibit an interface with the host tissue and the formation of a homogenous interface consisting of bone and void of intervening soft tissue is desired (osseointegration); recent developments have highlighted the benefit of incorporating nanostructures at that interface. Autograft and allograft bone are frequently used for bone loss, nonunion fractures, and spinal fusions; however, both are plagued with complications either due to supply or inadequate graft properties. In contrast to bone tissue engineering, which uses a top-down approach to repair bone defects, bone regenerative engineering uses a bottom-up approach focused on strategies incorporating stem cells, biomaterials, and growth factors alone or in combination to generate or regenerate bone tissue. Early constructs developed for bone regenerative engineering utilized polymeric microstructures, presenting surface features with characteristic dimensions similar to that of a cell (1µm - 1000µm). These microstructures were typically biodegradable and demonstrated an excellent ability to match the mechanics of native bone tissue. They were also osteoconductive-capable of promoting osteoblast growth. On the other hand, the osteoinductive abilities of these microstructures were lacking. Osteoinduction, or the ability to promote the progression of a preosteoblastic cell to a mature osteoblast, historically was achieved in two ways: via the addition of nanoscale ceramics to the microstructures or via an external stimulus such as the addition of bone morphogenetic proteins (BMPs). More recent developments in bone regenerative engineering have utilized polymeric nanostructures (less than 1µm) with characteristic dimensions an order of magnitude or more less than that of a cell to stimulate and drive an osteoinductive response in the absence of growth factors. Despite strong literature evidence supporting the nanostructures' ability to be both osteoconductive and osteoinductive, there is still disparity regarding how nanostructures regulate the progression towards an osteoblastic phenotype. This review will explore unique micro- and nano-architectures, how they initiate osteoinductive signals through pathways similar to BMPs, and how these unique geometries can be translated to the clinic. PMID:23432675

Ozdemir, Tugba; Higgins, Andrew M; Brown, Justin L

2013-01-01

150

Solar Airplanes and Regenerative Fuel Cells  

NASA Technical Reports Server (NTRS)

A solar electric aircraft with the potential to "fly forever" has captured NASA's interest, and the concept for such an aircraft was pursued under Aeronautics Environmental Research Aircraft and Sensor Technology (ERAST) project. Feasibility of this aircraft happens to depend on the successful development of solar power technologies critical to NASA's Exploration Initiatives; hence, there was widespread interest throughout NASA to bring these technologies to a flight demonstration. The most critical is an energy storage system to sustain mission power during night periods. For the solar airplane, whose flight capability is already limited by the diffuse nature of solar flux and subject to latitude and time of year constraints, the feasibility of long endurance flight depends on a storage density figure of merit better than 400-600 watt-hr per kilogram. This figure of merit is beyond the capability of present day storage technologies (other than nuclear) but may be achievable in the hydrogen-oxygen regenerative fuel cell (RFC). This potential has led NASA to undertake the practical development of a hydrogen-oxygen regenerative fuel cell, initially as solar energy storage for a high altitude UAV science platform but eventually to serve as the primary power source for NASAs lunar base and other planet surface installations. Potentially the highest storage capacity and lowest weight of any non-nuclear device, a flight-weight RFC aboard a solar-electric aircraft that is flown continuously through several successive day-night cycles will provide the most convincing demonstration that this technology's widespread potential has been realized. In 1998 NASA began development of a closed cycle hydrogen oxygen PEM RFC under the Aeronautics Environmental Research Aircraft and Sensor Technology (ERAST) project and continued its development, originally for a solar electric airplane flight, through FY2005 under the Low Emissions Alternative Power (LEAP) project. Construction of the closed loop system began in 2002 at the NASA Glenn Research Center in Cleveland, Ohio. System checkout was completed, and testing began, in July of 2003. The initial test sequences were done with only a fuel cell or electrolyzer in the test rig. Those tests were used to verify the test apparatus, procedures, and software. The first complete cycles of the fully closed loop, regenerative fuel cell system were successfully completed in the following September. Following some hardware upgrades to increase reactant recirculation flow, the test rig was operated at full power in December 2003 and again in January 2004. In March 2004 a newer generation of fuel cell and electrolyzer stacks was substituted for the original hardware and these stacks were successfully tested at full power under cyclic operation in June of 2004.

Bents, David J.

2007-01-01

151

Neonatal screening for congenital adrenal hyperplasia.  

PubMed Central

Capillary blood samples from 42930 infants born in the Italian region of Emilia-Romagna were collected for 17-hydroxyprogesterone radioimmunoassays on days 2, 3, 4, 5, 6, and 7, or between days 7 and 15 of life. A microfilter paper method modified from that of Pang et al.1 was used for this assay. Pathologic values of 17-hydroxyprogesterone were found in 5 infants giving an incidence in this homogeneous Caucasian population of 1:8586. We also investigated 17-hydroxyprogesterone values in relation to the day of sampling and the possible correlation between 17-hydroxyprogesterone values and birthweight and gestational age. We concluded that neonatal screening for congenital adrenal hyperplasia caused by 21-hydroxylase deficiency was possible by this method and that the infants' maturity and the particular day of collection of the samples affect the values but not the validity of the screening. PMID:6639129

Cacciari, E; Balsamo, A; Cassio, A; Piazzi, S; Bernardi, F; Salardi, S; Cicognani, A; Pirazzoli, P; Zappulla, F; Capelli, M

1983-01-01

152

Microwave Treatment of Prostate Cancer and Hyperplasia  

NASA Technical Reports Server (NTRS)

Microwave ablation in the form of microwave energy applied to a heart muscle by a coaxial catheter inserted in a vein in the groin area can be used to heat and kill diseased heart cells. A microwave catheter has been developed to provide deep myocardial ablation to treat ventricular tachycardia by restoring appropriate electrical activity within the heart and eliminating irregular heartbeats. The resulting microwave catheter design, which is now being developed for commercial use in treating ventricular tachycardia, can be modified to treat prostate cancer and benign prostatic hyperplasia (BPH). Inasmuch as the occurrence of BPH is increasing currently 350,000 operations per year are performed in the United States alone to treat this condition this microwave catheter has significant commercial potential.

Arndt, G. Dickey; Ngo, Phong; Carl, J. R.; Raffoul, George

2005-01-01

153

Regenerative medicine: the emergence of an industry  

PubMed Central

Over the last quarter of a century there has been an emergence of a tissue engineering industry, one that has now evolved into the broader area of regenerative medicine. There have been ‘ups and downs’ in this industry; however, it now appears to be on a track that may be described as ‘back to the future’. The latest data indicate that for 2007 the private sector activity in the world for this industry is approaching $2.5 billion, with 167 companies/business units and more than 6000 employee full time equivalents. Although small compared with the medical device and also the pharmaceutical industries, these numbers are not insignificant. Thus, there is the indication that this industry, and the related technology, may still achieve its potential and address the needs of millions of patients worldwide, in particular those with needs that currently are unmet. PMID:20843840

Nerem, Robert M.

2010-01-01

154

Heat cascading regenerative sorption heat pump  

NASA Technical Reports Server (NTRS)

A simple heat cascading regenerative sorption heat pump process with rejected or waste heat from a higher temperature chemisorption circuit (HTCC) powering a lower temperature physisorption circuit (LTPC) which provides a 30% total improvement over simple regenerative physisorption compression heat pumps when ammonia is both the chemisorbate and physisorbate, and a total improvement of 50% or more for LTPC having two pressure stages. The HTCC contains ammonia and a chemisorbent therefor contained in a plurality of canisters, a condenser-evaporator-radiator system, and a heater, operatively connected together. The LTPC contains ammonia and a physisorbent therefor contained in a plurality of compressors, a condenser-evaporator-radiator system, operatively connected together. A closed heat transfer circuit (CHTC) is provided which contains a flowing heat transfer liquid (FHTL) in thermal communication with each canister and each compressor for cascading heat from the HTCC to the LTPC. Heat is regenerated within the LTPC by transferring heat from one compressor to another. In one embodiment the regeneration is performed by another CHTC containing another FHTL in thermal communication with each compressor. In another embodiment the HTCC powers a lower temperature ammonia water absorption circuit (LTAWAC) which contains a generator-absorber system containing the absorbent, and a condenser-evaporator-radiator system, operatively connected together. The absorbent is water or an absorbent aqueous solution. A CHTC is provided which contains a FHTL in thermal communication with the generator for cascading heat from the HTCC to the LTAWAC. Heat is regenerated within the LTAWAC by transferring heat from the generator to the absorber. The chemical composition of the chemisorbent is different than the chemical composition of the physisorbent, and the absorbent. The chemical composition of the FHTL is different than the chemisorbent, the physisorbent, the absorbent, and ammonia.

Jones, Jack A. (Inventor)

1995-01-01

155

The TMI Regenerative Solid Oxide Fuel Cell  

NASA Technical Reports Server (NTRS)

Energy storage and production in space requires rugged, reliable hardware which minimizes weight, volume, and maintenance while maximizing power output and usable energy storage. Systems generally consist of photovoltaic solar arrays which operate (during sunlight cycles) to provide system power and regenerate fuel (hydrogen) via water electrolysis and (during dark cycles) fuel cells convert hydrogen into electricity. Common configurations use two separate systems (fuel cell and electrolyzer) in conjunction with photovoltaic cells. Reliability, power to weight and power to volume ratios could be greatly improved if both power production (fuel cells) and power storage (electrolysis) functions can be integrated into a single unit. The solid oxide fuel cell (SOFC) based design integrates fuel cell and electrolyzer functions and potentially simplifies system requirements. The integrated fuel cell/electrolyzer design also utilizes innovative gas storage concepts and operates like a rechargeable 'hydrogen-oxygen battery'. Preliminary research has been completed on improved H2/H20 electrode (SOFC anode/electrolyzer cathode) materials for regenerative fuel cells. Tests have shown improved cell performance in both fuel and electrolysis modes in reversible fuel cell tests. Regenerative fuel cell efficiencies, ratio of power out (fuel cell mode) to power in (electrolyzer mode), improved from 50 percent using conventional electrode materials to over 80 percent. The new materials will allow a single SOFC system to operate as both the electolyzer and fuel cell. Preliminary system designs have also been developed to show the technical feasibility of using the design for space applications requiring high energy storage efficiencies and high specific energy. Small space systems also have potential for dual-use, terrestrial applications.

Cable, Thomas L.; Ruhl, Robert C.; Petrik, Michael

1996-01-01

156

Materials science tools for regenerative medicine  

NASA Astrophysics Data System (ADS)

Regenerative therapies originating from recent technological advances in biology could revolutionize medicine in the coming years. In particular, the advent of human pluripotent stem cells (hPSCs), with their ability to become any cell in the adult body, has opened the door to an entirely new way of treating disease. However, currently these medical breakthroughs remain only a promise. To make them a reality, new tools must be developed to surmount the new technical hurdles that have arisen from dramatic departure from convention that this field represents. The collected work presented in this dissertation covers several projects that seek to apply the skills and knowledge of materials science to this tool synthesizing effort. The work is divided into three chapters. The first deals with our work to apply Raman spectroscopy, a tool widely used for materials characterization, to degeneration in cartilage. We have shown that Raman can effectively distinguish the matrix material of healthy and diseased tissue. The second area of work covered is the development of a new confocal image analysis for studying hPSC colonies that are chemical confined to uniform growth regions. This tool has important application in understanding the heterogeneity that may slow the development of hPSC -based treatment, as well as the use of such confinement in the eventually large-scale manufacture of hPSCs for therapeutic use. Third, the use of structural templating in tissue engineering scaffolds is detailed. We have utilized templating to tailor scaffold structures for engineering of constructs mimicking two tissues: cartilage and lung. The work described here represents several important early steps towards large goals in regenerative medicine. These tools show a great deal of potential for accelerating progress in this field that seems on the cusp of helping a great many people with otherwise incurable disease.

Richardson, Wade Nicholas

157

Platelet gel: applications in dental regenerative surgery  

PubMed Central

Background Platelet growth factors obtained from platelet-rich plasma (PRP) are used in prosthetic and periodontal regenerative therapy in dentistry. Increased microvascular proliferation in the first 20 days is followed by enhanced osteoblast activity and immature osteoid formation within 3–6 weeks, improving the quality and quantity of newly formed bone tissue. The aim of this study was to evaluate, through three-dimensional X-ray monitoring, the amount of bone obtained after bone regeneration treatment with platelet gel from autologous PRP. Materials and methods Patients eligible for regenerative treatment of atrophic alveolar bone of the maxilla or mandible were studied. The patients’ autologous whole blood was collected at the Department of Immunology and Transfusion of San Matteo Hospital for the preparation of platelet gel. The bone at the treated sites was analysed prior to and 4 months after the treatment using the three-dimensional X-ray system Galileos. Results Over a period of 6 years, 133 patients were treated: 304 implants were inserted and there were five cases of failure. The regenerated bone area consisted of histologically immature osteoid tissue composed of thin trabeculae of vital bone and nuclei of osteocytes, associated with fibro-connective tissue. Discussion This co-operative trial between the Transfusion Centre, for standardised production and validation of the platelet gel, and the Dental Surgery room for its application showed that the technique appears effective and safe. Although difficulties were encountered because of the small sample size and the inability to carry out long-term histological controls, the use of small amounts of PRP (5–10%) combined with autologous bone (15–20%) and alloplastic material appears to reduce the need for bone grafting. PMID:22790266

Forni, Franco; Marzagalli, Massimo; Tesei, Patrizia; Grassi, Alessandra

2013-01-01

158

Infantile galactosialidosis presenting with congenital adrenal hyperplasia and renal hypertension.  

PubMed

A patient with early infantile galactosialidosis presenting as congenital adrenal hyperplasia with clitoral hypertrophy and arterial hypertension is reported. Serum 17-alpha-OH-progesterone and plasma renin levels were elevated. Adrenal hyperplasia and thickening of the cardiac septum were detected by sonography; however, progressive hepatosplenomegaly, increasingly coarse features, and vacuolization of bone marrow and liver cells suggested a storage disorder. Combined deficiency of beta-galactosidase and sialidase enzyme activity in both lymphocytes and cultured fibroblasts was detected. This patient with early infantile galactosialidosis is the first reported who presented with congenital adrenal hyperplasia. PMID:8216548

Kyllerman, M; Månsson, J E; Westphal, O; Conradi, N; Nellström, H

1993-01-01

159

MX-INDUCED URINARY BLADDER EPITHELIAL HYPERPLASIA IN EKER RATS  

EPA Science Inventory

MX-INDUCED URINARY BLADDER EPITHELIAL HYPERPLASIA IN EKER RATS Epidemiological studies have shown a positive association between chronic exposure to chlorinated drinking water and human cancer, particularly of the urinary bladder. MX (3- chloro-4-(dichloromethyl)-5-hydrox...

160

Ortho-surgical management of condylar hyperplasia: Rare case reports  

PubMed Central

Condylar hyperplasia of the mandible is a clinical condition of over-development and growth because of excessive cellular growth of one condylar part of the mandible leading to facial asymmetry, mandibular deviation and enlargement of condyle. The elongation of the condylar neck in turn leads to malocclusion and articular dysfunction. In the past the interceptive and corrective procedures of growth and deformity in condylar hyperplasia were either condylectomy or high condylotomy. However, the deformity ceases after growth is completed. Therefore, other surgical procedures have to be undertaken to correct the manifested deformity of condylar hyperplasia. Further it has to be stressed that no single procedure can completely correct the deformity. So in addition to condylectomy, other orthognathic surgical procedures both on body and ramus and also on maxilla can be undertaken to correct the canting of occlusion. Two rare cases of unilateral hyperplasia encountered in our hospital are presented which required different lines of treatment. PMID:25298720

Singh, Virendra; Verma, Ajay; Attresh, Gyanander; Batra, Jitender

2014-01-01

161

Impact of nonpenetrating clips on intimal hyperplasia of vascular anastomoses  

Microsoft Academic Search

Non-penetrating, arcuate-legged titanium clips create an interrupted, non-penetrated, yet compliant vascular anastomoses that is associated with significantly reduced anastomotic neointimal hyperplasia. Recent experimental and clinical studies provide evidence that the non-suture alternative changes the biology of vessel-to-vessel and graft-to-vessel connections that reduces the stimulus for hyperplasia at a number of critical points in the response to injury schema. The compliant,

S. S. Berman; W. M. Kirsch; Y. H. Zhu; L. Anton; Y. Chai

2001-01-01

162

Clinical associations of hepatic stellate cell (HSC) hyperplasia.  

PubMed

Hepatic stellate cell (HSC) hyperplasia has been principally attributed to hypervitaminosis A. There are sporadic reports of HSC hyperplasia in other conditions such as chronic biliary disease and hepatitis C, but clinical associations of this entity have not been studied in detail. We aimed to investigate the clinical associations of HSC hyperplasia aside from hypervitaminosis A. We identified 34 patients whose liver histology showed HSC hyperplasia. We reviewed the liver samples; additional histologic findings in addition to HSC hyperplasia were consolidated into a histologic diagnosis. We collected clinical, laboratory, and radiologic data; the histologic diagnosis was combined with this data to reach an "overall diagnosis." Four patients had hypervitaminosis A (all native livers). In native livers (n = 24), HSC hyperplasia also occurred in association with drug-induced hepatitis [n = 6, niacin was the most common inducing agent (n = 3)], reactive hepatitis (n = 4), chronic hepatitis C (n = 4), autoimmune hepatitis (n = 3), steatohepatitis (n = 1), chronic biliary disease (n = 1), and portal venopathy (n = 1). In liver allografts (n = 10), HSC hyperplasia was seen in protocol biopsies without other significant abnormalities (n = 5), chronic biliary disease (n = 4), and acute cellular rejection (n = 1). All patients used medications (total of 99) and 82 % were on multiple medications. HSC hyperplasia is an uncommon and relatively nonspecific finding that most commonly occurs in multimedicated patients, often in the absence of hypervitaminosis A. Associated conditions include drug toxicity (such as niacin), post-liver transplant setting, reactive hepatitis (due to systemic illness or inflammatory disorders of the gastrointestinal tract), and chronic liver disease. PMID:24809674

Mounajjed, Taofic; Graham, Rondell P; Sanderson, Schuyler O; Smyrk, Thomas C

2014-07-01

163

Comparison of spontaneous and experimentally induced canine prostatic hyperplasia.  

PubMed Central

Spontaneous prostatic hyperplasia in the beagle appears to progress with age from a glandular to a cystic histological appearance. Prostatic hyperplasia can be induced in young beagles with intact testes by treatment for 4 mo with either dihydrotestosterone or 5 alpha-androstane-3 alpha, 17 beta-diol, alone, or with either of these steroids in combination with 17 beta-estradiol. In contrast, the induction of prostatic hyperplasia in young castrated beagles, in which the gland had been allowed to involute for 1 mo, requires the administration of both 17 beta-estradiol and either 5 alpha-androstane-3 alpha, 17 beta-diol or dihydrotestosterone. Testosterone and 17 beta-estradiol, either singly or in combination, did not produce the hyperplastic condition in intact or castrated beagles. The experimentally induced prostatic hyperplasia is identical in pathology to the glandular hyperplasia that occurs naturally in the aging dog with intact testes. However, cystic hyperplasia was not produced by any of the treatments tested in young animals. Images PMID:89121

DeKlerk, D P; Coffey, D S; Ewing, L L; McDermott, I R; Reiner, W G; Robinson, C H; Scott, W W; Strandberg, J D; Talalay, P; Walsh, P C; Wheaton, L G; Zirkin, B R

1979-01-01

164

New Regenerative Cycle for Vapor Compression Refrigeration  

SciTech Connect

The main objective of this project is to confirm on a well-instrumented prototype the theoretically derived claims of higher efficiency and coefficient of performance for geothermal heat pumps based on a new regenerative thermodynamic cycle as comparing to existing technology. In order to demonstrate the improved performance of the prototype, it will be compared to published parameters of commercially available geothermal heat pumps manufactured by US and foreign companies. Other objectives are to optimize the design parameters and to determine the economic viability of the new technology. Background (as stated in the proposal): The proposed technology closely relates to EERE mission by improving energy efficiency, bringing clean, reliable and affordable heating and cooling to the residential and commercial buildings and reducing greenhouse gases emission. It can provide the same amount of heating and cooling with considerably less use of electrical energy and consequently has a potential of reducing our nations dependence on foreign oil. The theoretical basis for the proposed thermodynamic cycle was previously developed and was originally called a dynamic equilibrium method. This theory considers the dynamic equations of state of the working fluid and proposes the methods for modification of T-S trajectories of adiabatic transformation by changing dynamic properties of gas, such as flow rate, speed and acceleration. The substance of this proposal is a thermodynamic cycle characterized by the regenerative use of the potential energy of two-phase flow expansion, which in traditional systems is lost in expansion valves. The essential new features of the process are: (1) The application of two-step throttling of the working fluid and two-step compression of its vapor phase. (2) Use of a compressor as the initial step compression and a jet device as a second step, where throttling and compression are combined. (3) Controlled ratio of a working fluid at the first and second step of compression. In the proposed system, the compressor compresses the vapor only to 50-60% of the final pressure, while the additional compression is provided by a jet device using internal potential energy of the working fluid flow. Therefore, the amount of mechanical energy required by a compressor is significantly reduced, resulting in the increase of efficiency (either COP or EER). The novelty of the cycle is in the equipment and in the way the multi-staging is accomplished. The anticipated result will be a new refrigeration system that requires less energy to accomplish a cooling task. The application of this technology will be for more efficient designs of: (1) Industrial chillers, (2) Refrigeration plants, (3) Heat pumps, (4) Gas Liquefaction plants, (5) Cryogenic systems.

Mark J. Bergander

2005-08-29

165

Iron serves as diffusion barrier in thermally regenerative galvanic cell  

NASA Technical Reports Server (NTRS)

Pure iron or iron-coated diaphragm provides a hydrogen diffusion electrode for a thermally regenerative galvanic cell. It allows the gas to diffuse through its interatomic spaces and resists the corrosive action of the cell environment.

Crouthamel, C. E.

1967-01-01

166

Status of the Regenerative ECLSS Water Recovery System.  

National Technical Information Service (NTIS)

NASA has completed the delivery of the regenerative Water Recovery System (WRS) for the International Space Station (ISS). The major assemblies included in this system are the Water Processor Assembly (WPA) and Urine Processor Assembly (UPA). This paper s...

D. L. Carter

2009-01-01

167

Status of the Regenerative ECLS Water Recovery System.  

National Technical Information Service (NTIS)

The regenerative Water Recovery System (WRS) has completed its first full year of operation on the International Space Station (ISS). The major assemblies included in this system are the Water Processor Assembly (WPA) and Urine Processor Assembly (UPA). T...

D. L. Carter

2010-01-01

168

3. INSIDE BATCH FURNACE BUILDING, VIEW LOOKING NORTH AT REGENERATIVE ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. INSIDE BATCH FURNACE BUILDING, VIEW LOOKING NORTH AT REGENERATIVE BATCH FURNACES ON LEFT AND 5 TON CAPACITY CHARGING MACHINE ON RIGHT. - U.S. Steel Duquesne Works, 22-Inch Bar Mill, Along Monongahela River, Duquesne, Allegheny County, PA

169

Science and Ethics: Bridge to the Future for Regenerative Medicine  

PubMed Central

The objective of this article is to reflect on the relationship between regenerative medicine and ethics, using as references the Aristotelian concept of what is ethical and that of Raessler Van Potter about bioethics. To do this, I will briefly describe the advances in regenerative medicine with stem cells, the strategies for producing pluripotential cells without destroying human embryos, and the great potential of stem cells to improve life for Humanity, noting that for this to be possible, it is necessary to locate the role of regenerative medicine in the context of human values and well being. In this way, this article has a real perspective of the role that regenerative medicine can play in benefitting human beings and engendering respect for human and natural environments. PMID:24298338

Patricio, Ventura-Junca

2011-01-01

170

Regenerative fuel cell combines high efficiency with low cost  

NASA Technical Reports Server (NTRS)

Hydrogen/oxygen regenerative fuel cell stores electrical energy efficiently and inexpensively. The fuel cell has a high energy-to-weight ratio, and is adapted for a large number of cycles with deep discharge.

Doyle, H.; Frank, H.; Stephens, C. W.

1965-01-01

171

Performance analysis and comparision of ultracapacitor based regenerative braking system  

Microsoft Academic Search

In this paper three types of energy storage system for regenerative braking are presented. The advantages and disadvantages are discussed after the simulation and experimental results are presented. Problems are discussed and the design guidelines are suggested.

Tongzhen Wei; Sibo Wang; Xuhua Gao

2009-01-01

172

Cell sheet engineering for regenerative medicine: current challenges and strategies.  

PubMed

Substantial progress made in the areas of stem cell research and regenerative medicine has provided a number of innovative methods to repair or regenerate defective tissues and organs. Although previous studies regarding regenerative medicine, especially those involving induced pluripotent stem cells, have been actively promoted in the past decade, there remain some challenges that need to be addressed in order to enable clinical applications. Designed for use in clinical applications, cell sheet engineering has been developed as a unique, scaffold-free method of cell processing utilizing temperature-responsive cell culture vessels. Clinical studies using cell sheets have shown positive outcomes and will be translated into clinical practice in the near future. However, several challenges stand in the way of the industrialization of cell sheet products and the widespread acceptance of regenerative medicine based on cell sheet engineering. This review describes current strategies geared towards the realization of the regenerative medicine approach. PMID:24964041

Owaki, Toshiyuki; Shimizu, Tatsuya; Yamato, Masayuki; Okano, Teruo

2014-07-01

173

Regenerative Markov Chain Monte Carlo for any distribution.  

SciTech Connect

While Markov chain Monte Carlo (MCMC) methods are frequently used for difficult calculations in a wide range of scientific disciplines, they suffer from a serious limitation: their samples are not independent and identically distributed. Consequently, estimates of expectations are biased if the initial value of the chain is not drawn from the target distribution. Regenerative simulation provides an elegant solution to this problem. In this article, we propose a simple regenerative MCMC algorithm to generate variates for any distribution

Minh, D. (Biosciences Division); (California State Univ.)

2012-01-01

174

The regenerative medicine coalition. Interview with Frank-Roman Lauter.  

PubMed

Frank-Roman Lauter, Secretary General of the recently launched Regenerative Medicine Coalition, explains how the coalition was formed and what they hope to achieve. Frank-Roman Lauter has served as Secretary General of the Regenerative Medicine Coalition since 2012, and as Head of Business Development at Berlin-Brandenburg Center for Regenerative Therapies since 2007. Frank-Roman Lauter's interest is the organization of academic infrastructures to promote efficient translation of research findings into new therapies. He co-organizes joined strategy development for regenerative medicine clusters from seven European countries (FP7-EU Project) and has initiated cooperation between the California Institute for Regenerative Medicine and the German Federal Ministry for Education & Research, resulting in a joined funding program. Recently, he cofounded the international consortium of Regenerative Medicine translational centers (RMC; www.the-rmc.org ). Trained as a molecular biologist at the Max-Planck Institute in Berlin-Dahlem and at Stanford, he has 16 years of experience as an entrepreneur and life science manager in Germany and the USA. PMID:23210813

Lauter, Frank-Roman

2012-11-01

175

Regenerative life support system research and concepts  

NASA Technical Reports Server (NTRS)

Life support systems that involve recycling of atmospheres, water, food and waste are so complex that models incorporating all the interactions and relationships are vital to design, development, simulations, and ultimately to control of space qualified systems. During early modeling studies, FORTRAN and BASIC programs were used to obtain numerical comparisons of the performance of different regenerative concepts. Recently, models were made by combining existing capabilities with expert systems to establish an Intelligent Design Support Environment for simpliflying user interfaces and to address the need for the engineering aspects. Progress was also made toward modeling and evaluating the operational aspects of closed loop life support systems using Time-step and Dynamic simulations over a period of time. Example models are presented which show the status and potential of developed modeling techniques. For instance, closed loop systems involving algae systeMs for atmospheric purification and food supply augmentation, plus models employing high plants and solid waste electrolysis are described and results of initial evaluations are presented.

1988-01-01

176

Airway transplantation: a challenge for regenerative medicine  

PubMed Central

After more than 50 years of research, airway transplantation remains a major challenge in the fields of thoracic surgery and regenerative medicine. Five principal types of tracheobronchial substitutes, including synthetic prostheses, bioprostheses, allografts, autografts and bioengineered conduits have been evaluated experimentally in numerous studies. However, none of these works have provided a standardized technique for the replacement of the airways. More recently, few clinical attempts have offered encouraging results with ex vivo or stem cell–based engineered airways and tracheal allografts implanted after heterotopic revascularization. In 1997, we proposed a novel approach: the use of aortic grafts as a biological matrix for extensive airway reconstruction. In vivo regeneration of epithelium and cartilage were demonstrated in animal models. This led to the first human applications using cryopreserved aortic allografts that present key advantages because they are available in tissue banks and do not require immunosuppressive therapy. Favorable results obtained in pioneering cases have to be confirmed in larger series of patients with extensive tracheobronchial diseases. PMID:24059453

2013-01-01

177

Minimally invasive therapies for benign prostatic hyperplasia.  

PubMed

Currently, 3 categories of treatment are available for men with benign prostatic hyperplasia (BPH): (1) medicine, such as alpha-blockers and finasteride; (2) minimally invasive treatment, such as transurethral microwave thermotherapy and interstitial ablation using either radiofrequency or laser; and (3) surgical therapy. The 1990s have seen an explosion of transurethral technology to treat symptoms caused by bladder outlet obstruction secondary to BPH. Unlike surgical debulking procedures, the minimally invasive therapies attempt to treat patients without general or regional anesthesia, and even ambulatory procedures are performed in the office. Because of the demographics of patients with BPH, it is hoped that these minimally invasive options will relieve symptoms without any surgical complications and the side effects and compliance issues associated with medical therapy. It is important that urologists have a clear understanding of the clinical usefulness of these devices, so that the overall role of such treatment may be determined by science rather than marketing. Clinically, the degree of symptom score, peak flow, and quality-of-life improvement seen with all the minimally invasive techniques are similar. The techniques may differ in their ability to reach the maximum number of responders and achieve an acceptable duration of response, and the need for analgesia/sedation associated with each technique. This study will define the minimally invasive therapies and present the differences in catheter design and technique. The pathologic basis for these therapeutic options and the advantages and disadvantages of each will be discussed. Urologists must decide which therapy can be used in their office practice. The maximum numbers of responders and enhanced durability of the treatment can be achieved based on realistic expectations, proper selection of patients, and complete information on the potential of these devices. PMID:11750248

Blute, M L; Larson, T

2001-12-01

178

Cell-permeant peptide inhibitors of vasospasm and intimal hyperplasia  

PubMed Central

Outcomes from vein graft bypass are limited by graft failure, leading causes of which include intimal hyperplasia and vasospasm. Intimal hyperplasia remains the most common cause of graft failure, but no therapeutic modalities have been shown to prevent intimal hyperplasia in humans. The small heat shock proteins are a class of naturally occurring proteins in vascular smooth muscle. These proteins have an integral role in maintenance of vascular tone and in cellular defense against various stressors. Transduction domains have enabled intracellular therapeutic delivery of peptide analogs of heat shock proteins, as well as peptide inhibitors of the kinases that phosphorylate these proteins. These cell-permeant peptides have been shown to prevent vasospasm and intimal hyperplasia in vitro. Since vascular bypass using vein grafts is analogous to autologous organ transplantation, ex vivo treatment of the vein graft with cell-permeant peptide inhibitors of vasospasm and intimal hyperplasia prior to implantation provides a unique opportunity for targeted treatment of the graft to improve patency. PMID:23104826

Osgood, Michael J; Flynn, Charles R; Komalavilas, Padmini; Brophy, Colleen

2014-01-01

179

A novel unitized regenerative proton exchange membrane fuel cell  

NASA Technical Reports Server (NTRS)

A difficulty encountered in designing a unitized regenerative proton exchange membrane (PEM) fuel cell lies in the incompatibility of electrode structures and electrocatalyst materials optimized for either of the two functions (fuel cell or electrolyzer) with the needs of the other function. This difficulty is compounded in previous regenerative fuel cell designs by the fact that water, which is needed for proton conduction in the PEM during both modes of operation, is the reactant supplied to the anode in the electrolyzer mode of operation and the product formed at the cathode in the fuel cell mode. Drawbacks associated with existing regenerative fuel cells have been addressed in work performed at Lynntech. In a first innovation, electrodes function either as oxidation electrodes (hydrogen ionization or oxygen evolution) or as reduction electrodes (oxygen reduction or hydrogen evolution) in the fuel cell and electrolyzer modes, respectively. Control of liquid water within the regenerative fuel cell has been brought about by a second innovation. A novel PEM has been developed with internal channels that permit the direct access of water along the length of the membrane. Lateral diffusion of water along the polymer chains of the PEM provides the water needed at electrode/PEM interfaces. Fabrication of the novel unitized regenerative fuel cell and results obtained on testing it will be presented.

Murphy, O. J.; Cisar, A. J.; Gonzalez-Martin, A.; Salinas, C. E.; Simpson, S. F.

1995-01-01

180

A Novel Unitized Regenerative Proton Exchange Membrane Fuel Cell  

NASA Technical Reports Server (NTRS)

A difficulty encountered in designing a unitized regenerative proton exchange membrane (PEM) fuel cell lies in the incompatibility of electrode structures and electrocatalyst materials optimized for either of the two functions (fuel cell or electrolyzer) with the needs of the other function. This difficulty is compounded in previous regenerative fuel cell designs by the fact that water, which is needed for proton conduction in the PEM during both modes of operation, is the reactant supplied to the anode in the electrolyzer mode of operation and the product formed at the cathode in the fuel cell mode. Drawbacks associated with existing regenerative fuel cells have been addressed. In a first innovation, electrodes function either as oxidation electrodes (hydrogen ionization or oxygen evolution) or as reduction electrodes (oxygen reduction or hydrogen evolution) in the fuel cell and electrolyzer modes, respectively. Control of liquid water within the regenerative fuel cell has been brought about by a second innovation. A novel PEM has been developed with internal channels that permit the direct access of water along the length of the membrane. Lateral diffusion of water along the polymer chains of the PEM provides the water needed at electrode/PEM interfaces. Fabrication of the novel single cell unitized regenerative fuel cell and results obtained on testing it are presented.

Murphy, O. J.; Cisar, A. J.; Gonzalez-Martin, A.; Salinas, C. E.; Simpson, S. F.

1996-01-01

181

Rethinking Regenerative Medicine: A Macrophage-Centered Approach  

PubMed Central

Regenerative medicine, a multi-disciplinary approach that seeks to restore form and function to damaged or diseased tissues and organs, has evolved significantly during the past decade. By adapting and integrating fundamental knowledge from cell biology, polymer science, and engineering, coupled with an increasing understanding of the mechanisms which underlie the pathogenesis of specific diseases, regenerative medicine has the potential for innovative and transformative therapies for heretofore unmet medical needs. However, the translation of novel technologies from the benchtop to animal models and clinical settings is non-trivial and requires an understanding of the mechanisms by which the host will respond to these novel therapeutic approaches. The role of the innate immune system, especially the role of macrophages, in the host response to regenerative medicine based strategies has recently received considerable attention. Macrophage phenotype and function have been suggested as critical and determinant factors in downstream outcomes. The constructive and regulatory, and in fact essential, role of macrophages in positive outcomes represents a significant departure from the classical paradigms of host–biomaterial interactions, which typically consider activation of the host immune system as a detrimental event. It appears desirable that emerging regenerative medicine approaches should not only accommodate but also promote the involvement of the immune system to facilitate positive outcomes. Herein, we describe the current understanding of macrophage phenotype as it pertains to regenerative medicine and suggest that improvement of our understanding of context-dependent macrophage polarization will lead to concurrent improvement in outcomes. PMID:25408693

Brown, Bryan N.; Sicari, Brian M.; Badylak, Stephen F.

2014-01-01

182

Sclerosing Lobular Hyperplasia- Correlation between Cytomorphological and Histological Findings  

PubMed Central

Sclerosing lobular hyperplasia of the mammary gland is an uncommmon benign lesion which is mainly seen in adolescents and young women. The breast lobules are enlarged due to ductal and acinar proliferations but they have normal architecture. There is extensive fibrosis of the intralobular stroma, and to a lesser degree, of the interlobular parenchyma. Patients generally complain of a palpable, painless/slightly tender and well-defined lump in breast. Fine-needle aspiration cytology of sclerosing lobular hyperplasia is non diagnostic with features similar to fibroadneoma except for the absence of stromal fragments. In order to reach a definitive diagnosis, a histopathologic evaluation is needed. However, a distinction between the two benign entities is of no clinical significance.We are describing a case of sclerosing lobular hyperplasia that occurred in the left breast of a 26-year-old lady. PMID:24783103

Lamichaney, Rachna; Sherpa, Mingma; Pradhan, Diwakar

2014-01-01

183

[Intimal hyperplasia within a vascular anastomosis].  

PubMed

Intimal hyperplasia (IH) appears to rank high amongst plausible causes of reconstructed arteries restenosis. It always occurs in the area of a surgical intervention on a vessel in response to a mechanical lesion. IH is the cause of thrombosis in 15 to 50% of cases following vascular reconstruction during the first year after the operation (with the exception of early thromboses, which are probably caused by an improperly performed interventional technique). Of a wide variety of clinical situations leading to development of IH in the vascular wall, for the purposes of the present review, we singled out the problem concerning the onset and development of this tissue reaction in intervascular anastomoses, which is currently one of the most important issues. Analysing the publications on the problem concerned showed that amongst significantfactors influencing the development of IH in the anastomosis, the investigators single out different parameters of the anastomoses, configuration (either an end-to-end or an end-to-side anastomosis, the use of special inserts and patches within the latter), as well as the use of autologous or synthetic conduits, blanket suture or interrupted suture, peculiarities of local haemodynamics (linear blood flow rate, distribution of parietal fraction forces, zones of stagnation and flow separation), etc. To a certain degree, the published data are rather controversial. There remain many problems, which are either unaddressed as yet, or insufficiently studied, if at all. For instance, while establishing an anastomosis between a bypass graft and an artery, surgeons often resort to endarterectomy. It is not known whether or not this technique would influence the IH pattern in the anastomosis concerned. Neither is it clear whether the high velocity flow exerts a direct damaging action upon the endothelium, whether it promotes the development of IH in the area of the lesion, and if affirmative, then what the mechanisms of this effect really are. Not studied is the role of various types of synthetic fibres and synthetic grafts (except PTFE), various kinds of suture material in the development of IH in the zone of a vascular anastomosis concerned. This of course is far from being a complete list of the challenges requiring further investigation. PMID:19791568

Kur'ianov, P S; Razuvaev, A S; Vavilov, V N

2008-01-01

184

An extensive denture-induced hyperplasia of maxilla.  

PubMed

Denture-induced hyperplasia is a reactive lesion arising from excessive and chronic mechanical pressure on the vestibular oral mucosa. It has a female predilection and it is mostly seen in the maxilla. The size of the lesion may be as small as a few millimeters to massive lesion involving the entire vestibule. It is usually asymptomatic but sometimes severe inflammation and ulceration can occur. Elimination of the inflammation and excision of the lesion is the treatment of choice. Denture induced hyperplasia in right maxillary buccal vestibule in a middle age old female patient was presented. Surgical excision was done and new denture was fabricated. PMID:24349860

Veena, Km; Jagadishchandra, H; Sequria, J; Hameed, Sk; Chatra, L; Shenai, P

2013-11-01

185

Temporal mode structure of a regenerative amplifier with intracavity etalons  

SciTech Connect

The effects of intracavity etalons on the temporal-mode structure of a regenerative amplifier are studied both theoretically and experimentally. The analysis predicts the temporal profile of the regenerative amplifier output pulse given the temporal profile of the input pulse, the laser-cavity parameters, the etalon parameters, and the number of round trips that the injected pulse makes in the laser cavity. Several experiments were performed. The output pulse width of a regenerative amplifier with a single etalon was measured as we varied the thickness of the etalon and the number of round trips that the injected pulse makes in the laser cavity. With two etalons an injected 70-ps pulse width was stretched to 7 ns with no temporal modulation. The thermal sensitivity of an intracavity etalon was analyzed and measured. All experimental results agree well with theory.

Skeldon, M.D.; Bui, S.T. (Laboratory for Laser Energetics, University of Rochester, 250 East River Road, Rochester, New York 14623-1299 (United States))

1993-04-01

186

Lightweight pressure vessels and unitized regenerative fuel cells  

SciTech Connect

Energy storage systems have been designed using lightweight pressure vessels with unitized regenerative fuel cells (URFCs). The vessels provide a means of storing reactant gases required for URFCs; they use lightweight bladder liners that act as inflatable mandrels for composite overwrap and provide a permeation barrier. URFC systems have been designed for zero emission vehicles (ZEVs); they are cost competitive with primary FC powered vehicles that operate on H/air with capacitors or batteries for power peaking and regenerative braking. URFCs are capable of regenerative braking via electrolysis and power peaking using low volume/low pressure accumulated oxygen for supercharging the power stack. URFC ZEVs can be safely and rapidly (<5 min.) refueled using home electrolysis units. Reversible operation of cell membrane catalyst is feasible without significant degradation. Such systems would have a rechargeable specific energy > 400 Wh/kg.

Mitlitsky, F.; Myers, B.; Weisberg, A.H.

1996-09-06

187

Regenerative endodontics and tissue engineering: what the future holds?  

PubMed

The work performed by researchers in regenerative endodontics and tissue engineering over the last decades has been superb; however, many questions remain to be answered. The basic biologic mechanisms must be elucidated that will allow the development of dental pulp and dentin in situ. Stress must be placed on the many questions that will lead to the design of effective, safe treatment options and therapies. This article discusses those questions, the answers to which may become the future of regenerative endodontics. The future remains bright, but proper support and patience are required. PMID:22835545

Goodis, Harold E; Kinaia, Bassam Michael; Kinaia, Atheel M; Chogle, Sami M A

2012-07-01

188

A high-power compact regenerative amplifier FEL  

SciTech Connect

The Regenerative Amplifier FEL (RAFEL) is a new FEL approach aimed at achieving the highest optical power from a compact rf-linac FEL. The key idea is to feed back a small fraction (< 10%) of the optical power into a high-gain ({approximately}10{sup 5} in single pass) wiggler to enable the FEL to reach saturation in a few passes. This paper summarizes the design of a high-power compact regenerative amplifier FEL and describes the first experimental demonstration of the RAFEL concept.

Nguyen, D.C.; Sheffield, R.L.; Fortgang, C.M.; Kinross-Wright, J.M.; Ebrahim, N.A.; Goldstein, J.C.

1997-08-01

189

ECLSS regenerative systems comparative testing and subsystem selection  

NASA Technical Reports Server (NTRS)

In support of Space Station Freedom Phase C/D Environmental Control and Life Support Systems (ECLSS) regenerative systems development, comparative testing was performed on predevelopment hardware of competing technologies for each regenerative function. The purpose of the test program was to collect data on latest generation hardware in order to make final technology selections for each subassembly in the oxygen recovery and water reclamation strings. This paper discusses the testing performed, test results, and evaluation of these results relative to subsystem selections for CO2 reduction, O2 generation, potable water processing, hygiene water processing, and urine processing.

Carasquillo, Robyn L.; Carter, Donald L.; Holder, Donald W., Jr.; Mcgriff, Cindy F.; Ogle, Kathryn Y.

1991-01-01

190

Lenalidomide-induced regenerative macronodules infarction in a cirrhosis patient.  

PubMed

Hepatic regenerative macronodules observed in hepatic cirrhosis are sensitive to ischemia. Lenalidomide is a thalidomide analog used for the treatment of myelodysplastic syndromes, with pleiotropic activities including induction of apoptosis, inhibition of angiogenesis and broad immunomodulatory effects. It has been approved by the Food and Drug Administration (FDA) in the United States and by the European Medicines Agency (EMEA) in 2007 for the use in combination with dexamethasone in the treatment of relapsed or refractory multiple myeloma. We report a unique observation, which strongly suggests the role of Lenalidomide in hepatic regenerative macronodules infarction. PMID:23498774

Dangouloff-Ros, Volodia; Cervera, Pascale; Carbonell, Nicolas; Arrivé, Lionel

2013-04-01

191

Optimum performance of a regenerative Brayton thermal cycle  

NASA Astrophysics Data System (ADS)

The optimum performance of a regenerative Brayton cycle was analyzed. The model includes external and internal irreversibilities coming from four main sources: coupling to external heat reservoirs, turbine and compressor nonisentropic processes, pressure losses in the heater and the cooler, and the regenerator. In terms of the parameters accounting for each type of irreversibility, explicit numerical results are presented for the maximum efficiency, maximum power output, efficiency at maximum power output, power output at maximum efficiency, as well as for the pressure ratios required for maximum efficiency and maximum power. This analysis could provide a general theoretical tool for the optimal design and operation of real regenerative gas turbine power plants.

Roco, J. M. M.; Velasco, S.; Medina, A.; Hernández, A. Calvo

1997-09-01

192

Nanotechnology for regenerative medicine: nanomaterials for stem cell imaging.  

PubMed

Although stem cells hold great potential for the treatment of many injuries and degenerative diseases, several obstacles must be overcome before their therapeutic application can be realized. These include the development of advanced techniques to understand and control functions of microenvironmental signals and novel methods to track and guide transplanted stem cells. The application of nanotechnology to stem cell biology would be able to address those challenges. This review details the current challenges in regenerative medicine, the current applications of nanoparticles in stem cell biology and further potential of nanotechnology approaches towards regenerative medicine, focusing mainly on magnetic nanoparticle- and quantum dot-based applications in stem cell research. PMID:18694318

Solanki, Aniruddh; Kim, John D; Lee, Ki-Bum

2008-08-01

193

Research requirements for development of regenerative engines for helicopters  

NASA Technical Reports Server (NTRS)

The improved specific fuel consumption of the regenerative engine was compared to a simple-cycle turboshaft engine. The performance improvement and fuel saving are obtained at the expense of increased engine weight, development and production costs, and maintenance costs. Costs and schedules are estimated for the elements of the research and development program. Interaction of the regenerative engine with other technology goals for an advanced civil helicopter is examined, including its impact on engine noise, hover and cruise performance, helicopter empty weight, drive-system efficiency and weight, one-engine-inoperative hover capability, and maintenance and reliability.

Semple, R. D.

1976-01-01

194

Dihydrotestosterone and the concept of 5a-reductase inhibition in human benign prostatic hyperplasia  

Microsoft Academic Search

The development of human benign prostatic hyperplasia (BPH) clearly requires a combination of testicular androgens and the ageing process. Although the role of androgens as the causative factor for human benign prostatic hyperplasia is debated, they undoubtedly play, at least, a permissive role. The principal prostatic androgen is dihydrotestosterone. Although not elevated in human benign prostatic hyperplasia, dihydrotestosterone levels in

G. Bartsch; R. Rittmaster; H. Klocker

2002-01-01

195

A New 3-D Automated Computational Method to Evaluate In-Stent Neointimal Hyperplasia in  

E-print Network

A New 3-D Automated Computational Method to Evaluate In-Stent Neointimal Hyperplasia in In (PCI) and quantification of in-stent neointimal hyperplasia (NIH) are important. In this paper, we-Stent NIH 777 Although Drug Eluting Stents (DES) suppress NeoIntimal Hyperplasia (NIH) strongly, in

Yanikoglu, Berrin

196

Intimal Hyperplasia of the Infant Parasellar Carotid Artery A Potential Developmental Factor in Atherosclerosis and SIDS  

E-print Network

Intimal Hyperplasia of the Infant Parasellar Carotid Artery A Potential Developmental Factor for the occurrence of neonatal intimal hyperplasia. This study provides a topographic and morphometric analysis-aided 3D reconstruction. Intimal hyperplasia occurred at 3 characteristic locations of the pICA: (1

Müller, Gerd B.

197

Dihydrotestosterone and the Concept of 5?–Reductase Inhibition in Human Benign Prostatic Hyperplasia  

Microsoft Academic Search

Objective:The development of the human benign prostatic hyperplasia clearly requires a combination of testicular androgens and aging. Although the role of androgens as the causative factor for human benign prostatic hyperplasia is debated, they undoubtedly have at least a permissive role. The principal prostatic androgen is dihydrotestosterone (DHT). Although not elevated in human benign prostatic hyperplasia, DHT levels in the

G. Bartsch; R. S. Rittmaster; H. Klocker

2000-01-01

198

A study on regenerative braking for a parallel hybrid electric vehicle  

Microsoft Academic Search

In this paper, a regenerative braking algorithm is presented and performance of a hybrid electric vehicle (HEV) is investigated.\\u000a The regenerative braking algorithm calculates the available regenerative braking torque by considering the motor characteristics,\\u000a the battery SOC and the CVT speed ratio. When the regenerative braking and the friction braking are applied simultaneously,\\u000a the friction braking torque corresponding to the

Sungwook Jang; Hoon Yeo; Chulsoo Kim; Hyunsoo Kim

2001-01-01

199

The Experience of Neonatal Screening for Congenital Adrenal Hyperplasia  

Microsoft Academic Search

Without a neonatal screening programme for congenital adrenal hyperplasia (CAH), even in a country with a high level of medical assistance and sophisticated neonatal and endocrinological services, some patients affected by CAH may have died at birth or may remain undiagnosed.Copyright © 1992 S. Karger AG, Basel

A. Cicognani

1992-01-01

200

Mistaken gender identity in non-classical congenital adrenal hyperplasia  

PubMed Central

Gender identity is the sense of belonging that one feels for a particular sex psychologically and socially, independent of one's biological sex. There is much less systematic data on gender identity in females with congenital adrenal hyperplasia (CAH). We report a case of non-classical CAH presenting as a case of gender identity disorder. PMID:24891708

Kukreti, Prerna; Kandpal, Manish; Jiloha, R. C.

2014-01-01

201

Recent Developments in the Surgical Management of Benign Prostatic Hyperplasia  

Microsoft Academic Search

A new era in the surgical management of benign prostatic hyperplasia (BPH) has emerged in the past decade. A variety of less invasive treatment modalities have been introduced and well-established surgical treatments are being reassessed. Although progress has been made in the management of BPH, the substantial economic burden to the healthcare system caused by BPH emphasizes the importance of

Jan V Jepsen; Reginald C Bruskewitz

1998-01-01

202

Role of laser therapy in benign prostate hyperplasia (BPH)  

Microsoft Academic Search

Benign prostatic hyperplasia (BPH) is a common disease in males older than 50 years of age. 75-80% of this population is considered to have some degree of BPH causing clinical symptoms and requiring urological treatment. Transurethral resection of the prostate (TUR-P) is currently the standard surgical treatment modality for BPH. In an attempt to minimize the need for hospitalization and

Werner T. de Riese; Brent A. Sharpe; David B. Aronoff; Bernhard T. Mittemeyer

2001-01-01

203

Laser Treatment of Benign Prostatic Hyperplasia: Dosimetric and Thermodynamic Considerations  

Microsoft Academic Search

Benign prostatic hyperplasia (BPH) is the most commonly occurring neoplastic disease in the aging human male. Currently, surgical treatment of BPH is the primary therapeutic method. However, due to surgical complications, less invasive methods of treatment are desirable. In recent years, thermal coagulation of the hyperplastic prostate by a laser has received a considerable amount of attention. Nevertheless, the optimum

Bahman Anvari

1993-01-01

204

Historical Aspects of Laser Therapy for Benign Prostatic Hyperplasia  

Microsoft Academic Search

The gold standard treatment of benign prostatic hyperplasia (BPH) has been the transurethral resection of the prostate (TURP). However, this procedure is associated with a number of complications, and other surgical therapies, including laser prostatectomy, have been developed to overcome these issues. Laser prostatectomy involves tissue coagulation or vaporization. Coagulation of the tissue results in debulking of the gland through

Jean de la Rosette; Edward Collins; Alexander Bachmann; Benjamin Choi; Gordon Muir; Oliver Reich; Fernando Gómez Sancha; Shahin Tabatabaei; Henry Woo

2008-01-01

205

Hepatic focal nodular hyperplasia: angiography, CT, sonography, and scintigraphy  

SciTech Connect

Eleven patients with focal nodular hyperplasia of the liver underwent a combination of radiologic procedures, including sonography, computed tomography (CT), hepatic scintigraphy, and angiography. This paper describes the radiologic findings in this group of patients and reviews the current literature. In the present series, sonography was the most sensitive (100%) method for detection of focal nodular hyperplasia, while CT was able to detect only seven (78%) of nine cases. Arteriographic findings were felt to be characteristic in nine (82%) of 11 cases. Hepatic scintigraphy demonstrated normal colloid uptake in six (55%) of 11 lesions. In this series, an accurate radiologic diagnosis of focal nodular hyperplasia was made in 73% of cases. Hepatic scintigraphy is the pivotal examination. Normal colloid uptake by a focal hepatic mass is virtually diagnostic. However, in the patients in whom the colloid scan shows decreased or absent uptake, angiography may show findings diagnostic of focal nodular hyperplasia in up to 75% of cases, thus avoiding the need for liver biopsy or surgery.

Rogers, J.V. (Univ. of Washington, Seattle); Mack, L.A.; Freeny, P.C.; Johnson, M.L.; Sones, P.J.

1981-11-01

206

Early Hormonal Influences on Cognitive Functioning in Congenital Adrenal Hyperplasia.  

ERIC Educational Resources Information Center

Reports the results of cognitive test performance and early childhood activities in individuals with congenital adrenal hyperplasia, an autosomal recessive disorder associated with elevated prenatal adrenal androgen levels, demonstrating the effects of early exposure to excess androgenizing hormones on sexually dimorphic cognitive functioning.…

Resnick, Susan M.; And Others

1986-01-01

207

Psychosexual Development of Women with Congenital Adrenal Hyperplasia  

Microsoft Academic Search

Women with congenital adrenal hyperplasia (CAH) (N= 31) and their unaffected sisters or female cousins (N= 15) participated in a study of psychosexual development. All participants were ?18 years of age (mean age, 25 years; range, 18–40). Comparisons were also made between the CAH women with the salt-wasting (SW) form of the disorder and those with simple virilization (SV). A

Kenneth J. Zucker; Susan J. Bradley; Gillian Oliver; Jennifer Blake; Susan Fleming; Jane Hood

1996-01-01

208

[Micro-glandular hyperplasia of the cervix canal mucosa].  

PubMed

During the period of 1981-1990 2109 diagnostic-therapeutical curettages of the cervical canal and uterus were performed in the Department of Gynecology and Oncology of Medical Academy in Kraków. In histological examinations of scrapings 17 cases (0.8%) of micro-glandular hyperplasia limited to cervical canal have been found. In 14 out of analysed cases curettage have been performed due to metrorrhagia. There were 12 cases of myomatous uterine among them. Two cases were colposcopically suspected of CIN. One woman exhibited a cervical polyps. A connection between micro-glandular hyperplasia and pregnancy and particularly with oral contraception observed in other studies has not been determined. None of the 17 patients were pregnant. They took neither contraceptive pills nor were treated by female hormones. 15 out of examined patients had an estrogenic reaction in cytological evaluation. Decidual transformation of the uterine cervix has not been colposcopically found in any case. Coexistence of micro-glandular hyperplasia and severe dysplasia were revealed in two patients suspected cytologically and colposcopically of CIN. In one case micro-glandular hyperplasia parallel to squamous carcinoma of the cervix has been stated. PMID:8359742

Szczudrawa, A; Bogdanowicz, M; Pity?ski, K; Czekaj, A

1993-03-01

209

Estimated costs of treatment of benign prostate hyperplasia in Brazil  

Microsoft Academic Search

Introduction: The treatment of benign prostate hyperplasia (BPH) presents 2 options: medi- cal or surgical, and there are doubts about what is the best treatment since 80% of patients who undergo surgery become asymptomatic and 10 to 40% of those under medical regimen undergo sur- gery within a 5 years period. It is difficult to assess the actual costs of

Haylton J. Suaid; Marco A. Gonçalves; Antonio A. Rodrigues Jr; João P Cunha; Adauto J. Cologna; Antonio C. P. Martins

2003-01-01

210

The underestimated role of neointimal hyperplasia: balloon folding  

E-print Network

The underestimated role of neointimal hyperplasia: balloon folding M. De Beule, P. Mortier, D. Van and expansion data from both stents and balloons Virtual expansion of the Cypher (Cordis) stent by the inflation of a trifolded Raptor balloon using ABAQUS FEA software The balloon folding pattern seems a major factor

Gent, Universiteit

211

Orbital follicular hyperplasia in common variable immune deficiency syndrome.  

PubMed

Common variable immune deficiency (CVID) is characterized by reduced serum immune globulins and impaired or absent antibody responses. Patients become more susceptible to infections and to lymphoproliferation and granulomatous inflammation. Ophthalmic manifestations of CVID are rare. The authors describe a case of orbital follicular hyperplasia in a 15-year-old girl with CVID syndrome causing proptosis and exposure keratopathy. PMID:23446300

Gupta, Meenakashi; Shah, Ankoor S; Vergilio, Jo-Anne; Chou, Janet; Elliott, Alexandra

2013-01-01

212

Benign prostatic hyperplasia: age-related tissue-remodeling  

Microsoft Academic Search

Aging and androgens are the two established risk factors for the development of benign prostatic hyperplasia (BPH) and benign prostatic enlargement (BPE), which can lead to lower urinary tract symptoms (LUTS) in elderly men. BPH, consisting of a nodular overgrowth of the epithelium and fibromuscular tissue within transition zone and periurethral areas, is first detectable around the fourth decade of

Gerold Untergasser; Stephan Madersbacher; Peter Berger

2005-01-01

213

Androstenedione rhythms in saliva in congenital adrenal hyperplasia  

Microsoft Academic Search

Serial samples of saliva were collected at home by 17 patients being treated for congenital adrenal hyperplasia to determine the circadian rhythm of androstenedione as an index of therapeutic control. Single samples of blood for measurement of plasma testosterone, 170H-progesterone, and androstenedione concentrations were collected from these and a further seven patients for comparison. Plasma androstenedione concentrations showed a close

M C Young; R F Walker; D Riad-Fahmy; I A Hughes

1988-01-01

214

SPE (tm) regenerative hydrogen/oxygen fuel cells for extraterrestrial surface and microgravity applications  

NASA Technical Reports Server (NTRS)

Viewgraphs on SPE regenerative hydrogen/oxygen fuel cells for extraterrestrial surface and microgravity applications are presented. Topics covered include: hydrogen-oxygen regenerative fuel cell energy storage system; electrochemical cell reactions; SPE cell voltage stability; passive water removal SPE fuel cell; fuel cell performance; SPE water electrolyzers; hydrophobic oxygen phase separator; hydrophilic/electrochemical hydrogen phase separator; and unitized regenerative fuel cell.

Mcelroy, J. F.

1990-01-01

215

Design and implementation of a regenerative braking system for electric bicycles based on DSP  

Microsoft Academic Search

This paper proposes a regenerative braking system for electric bicycle based on DSP. The proposed method is used to adjust the switching sequence of the inverter, so that the braking energy will be returned to charge the battery. With the cooperation of regenerative braking energy recovery technologies and digital signal processor (TMS320LF2407) as the control unit, the regenerative braking energy

Chih-Chiang Hua; Shih-Jyun Kao

2011-01-01

216

Regenerative braking algorithm for a parallel hybrid electric vehicle with continuously variable transmission  

Microsoft Academic Search

A novel regenerative braking algorithm based on continuously variable transmission is proposed to make effective and maximum use of the brake energy in order to improve fuel economy. In the braking torque distribution of the novel regenerative algorithm, the regenerative torque is determined by considering the vehicle velocity, the maximal generation torque and state of the electric motor, the maximal

Wang Feng; Zhong Hu; Mao Xiao-jian; Yang Lin; Zhuo Bin

2007-01-01

217

Regenerative Braking for an Electric Vehicle Using Ultracapacitors and a Buck-Boost Converter  

E-print Network

Regenerative Braking for an Electric Vehicle Using Ultracapacitors and a Buck-Boost Converter Juan situation (regenerative braking), the battery voltage goes up, and then the control needs to activate regenerative braking can be avoided #12;with the help of ultracapacitors. Besides, ultracapacitors allow

Catholic University of Chile (Universidad Católica de Chile)

218

Analysis of compressed air regenerative braking and a thermally enhanced option  

Microsoft Academic Search

Obtaining a net benefit from regenerative braking is difficult. Various forms of regenerative braking systems have been proposed. They include electric batteries, capacitors, flywheels, and compressed air. Some have been implemented on a limited scale. The benefits of regenerative braking systems are easy to qualitatively describe, but can be challenging to quantify. The potential benefits depend upon obvious things such

F. Wicks; J. Maleszweski; C. Wright; J. Zarybnicky

2002-01-01

219

Regenerative braking for electric vehicle based on fuzzy logic control strategy  

Microsoft Academic Search

In order to recycle more energy in the process of regenerative braking, we design a regenerative braking force calculation controller based on fuzzy logic. The sugeno's interface fuzzy logic controller has three-inputs including the driver's brake requirements, vehicle speed and batteries' SOC and one-output which is the regenerative braking force. To ensure charging safety, the influence of batteries' temperature is

Zijian Zhang; Guoqing Xu; Weimin Li; Liang Zheng

2010-01-01

220

Dual Mode Vehicle with In-Wheel Motor: Regenerative Braking Optimization  

E-print Network

Dual Mode Vehicle with In-Wheel Motor: Regenerative Braking Optimization G. Le Solliec1*, A. Chasse: Regenerative Braking Optimization -- To meet the growing need for mobility of people and goods while massively the benefit of such an architecture to optimize the regenerative braking while ensuring a safe dynamic

Paris-Sud XI, Université de

221

California Institute for Regenerative Medicine (CIRM) Stem Cell Basics Videos  

NSDL National Science Digital Library

This collection of videos, from the California Institute for Regenerative Medicine, features researchers as they "explain the basics of stem cell research and discuss the many hurdles in translating the basic research into new therapies." Some of the topics covered here include: creating embryonic stem cell lines, therapies based on cancer stem cells, therapy development, stem cell differentiation, ethics, and more.

2012-03-28

222

Self Regenerative Markov Chain Monte Carlo with Sujit K. Sahu  

E-print Network

Self Regenerative Markov Chain Monte Carlo with Adaptation Sujit K. Sahu Faculty of Mathematical{Hastings algorithm; Regeneration. 1 Introduction Markov Chain Monte Carlo (MCMC) is a key technique for calculating performed, we go on to simulate another independent candidate point from the proposal distribution

Sahu, Sujit K

223

REGENERATIVE MEDICINE Tracking Stem Cell Differentiation in the Setting  

E-print Network

a central goal in CNS regenerative medicine. Channelrhodopsin-2 (ChR2) is a rapidly gated blue light-sensitive by fluorescence activated cell sorting (FACS). Illumination of resulting ChR2-ESCs with pulses of blue light differentiation, with high-speed optical switching on a custom robotic stage with environmental chamber

Schnitzer, Mark

224

Stem Cells, Regenerative Medicine, and Animal Models of Disease  

Microsoft Academic Search

The field of stem cell biology and regenerative medicine is rapidly moving toward translation to clinical practice, and in doing so has become even more dependent on animal donors and hosts for generating cellular reagents and assay- ing their potential therapeutic efficacy in models of human disease. Advances in cell culture technologies have revealed a remarkable plasticity of stem cells

Dennis A. Steindler

2007-01-01

225

A New Three-Phase Rectifier for Regenerative Braking Application  

Microsoft Academic Search

This paper proposes a new regenerative rectifier for motor loads. The controller is implemented with simple analog components. Yet, it has the power of controlling a three-phase Voltage Source Inverter to operate either as a Power Factor Correction rectifier or as a Grid Connected Inverter according to motor's operational status. In both cases, the currents are sinusoidal. A 5 KW

Lihua Li; Keyue Smedley; Taotao Jin

2007-01-01

226

Energy savings through regenerative braking using retrofit converters  

Microsoft Academic Search

This paper explores the benefits and feasibility of retrofitting existing phase controlled DC motor drives in the Queensland Rail coal transport system with PWM rectifier technology. The major benefits of this would be, the replacement of the dynamic brake with a regenerative system and unity power factor operation with a high quality input current waveshape. Test results indicate that very

Frank Flinders; Rajan Mathew; Wardina Oghanna

1995-01-01

227

Modeling and Simulation about an Electric Car's Regenerative Braking System  

Microsoft Academic Search

A kind of regenerative braking system of an electric car is studied in the paper. The car's speed, acceleration, the hydraulic accumulator's pressure and volume are simulated with Matlab while the electric car is braking or accelerating from stop. The hydraulic accumulator can absorb all of the braking energy when braking and the energy stored in the hydraulic accumulator can

Zuowu Ding; Dongbiao Zhao; Jianmin Zuo

2007-01-01

228

Adipose-Derived Stem Cells for Regenerative Medicine  

Microsoft Academic Search

Abstract—The emerging field of regenerative medicine will require a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue represents an abundant and accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in

Gary Lopaschuk; Jeffrey M. Gimble; Adam J. Katz; Bruce A. Bunnell

2010-01-01

229

Potential of Human Embryonic Stem Cells in Regenerative Medicine  

Microsoft Academic Search

Stem cells can give rise to more stem cells or differentiate into more specialized cells. In the last 5 years not only have researchers succeeded in isolating human embryonic stem (hES) cell lines but also in identifying adult stem cells with possible pluripotent differentiation capacity. The shortage of donor organs or tissues for regenerative medicine has further stimulated research into

Robert Passier

2003-01-01

230

Feasibility Study of Regenerative Burners in Aluminum Holding Furnaces  

NASA Astrophysics Data System (ADS)

Gas-fired aluminum holding reverberatory furnaces are currently considered to be the lowest efficiency fossil fuel system. A considerable volume of gas is consumed to hold the molten metal at temperature that is much lower than the flame temperature. This will lead to more effort and energy consumption to capture the excessive production of the CO2. The concern of this study is to investigate the feasibility of the regenerative-burners' furnaces to increase the furnace efficiency to reduce gas consumption per production and hence result in less CO2 production. Energy assessments for metal holding furnaces are considered at different operation conditions. Onsite measurements, supervisory control and data acquisition data, and thermodynamics analysis are performed to provide feasible information about the gas consumption and CO2 production as well as area of improvements. In this study, onsite measurements are used with thermodynamics modeling to assess a 130 MT rectangular furnace with two regenerative burners and one cold-air holding burner. The assessment showed that the regenerative burner furnaces are not profitable in saving energy, in addition to the negative impact on the furnace life. However, reducing the holding and door opening time would significantly increase the operation efficiency and hence gain the benefit of the regenerative technology.

Hassan, Mohamed I.; Al Kindi, Rashid

2014-09-01

231

Bromodeoxyuridine Specifically Labels the Regenerative Stem Cells of Planarians  

Microsoft Academic Search

The singular regenerative abilities of planarians require a population of stem cells known as neoblasts. In response to wounding, or during the course of cell turnover, neoblasts are signaled to divide and\\/or differentiate, thereby replacing lost cell types. The study of these pluripotent stem cells and their role in planarian regeneration has been severely hampered by the reported inability of

Phillip A. Newmark; Alejandro Sánchez Alvarado

2000-01-01

232

High energy density regenerative fuel cell systems for terrestrial applications  

Microsoft Academic Search

Regenerative Fuel Cell System (RFCS) technology for energy storage has been a NASA power system concept for many years. Compared to battery-based energy storage systems, RFCS has received relatively little attention or resources for development because the energy density and electrical efficiency were not sufficiently attractive relative to advanced battery systems. Even today, RFCS remains at a very low technology

K. A. Burke

1999-01-01

233

Feasibility Study of Regenerative Burners in Aluminum Holding Furnaces  

NASA Astrophysics Data System (ADS)

Gas-fired aluminum holding reverberatory furnaces are currently considered to be the lowest efficiency fossil fuel system. A considerable volume of gas is consumed to hold the molten metal at temperature that is much lower than the flame temperature. This will lead to more effort and energy consumption to capture the excessive production of the CO2. The concern of this study is to investigate the feasibility of the regenerative-burners' furnaces to increase the furnace efficiency to reduce gas consumption per production and hence result in less CO2 production. Energy assessments for metal holding furnaces are considered at different operation conditions. Onsite measurements, supervisory control and data acquisition data, and thermodynamics analysis are performed to provide feasible information about the gas consumption and CO2 production as well as area of improvements. In this study, onsite measurements are used with thermodynamics modeling to assess a 130 MT rectangular furnace with two regenerative burners and one cold-air holding burner. The assessment showed that the regenerative burner furnaces are not profitable in saving energy, in addition to the negative impact on the furnace life. However, reducing the holding and door opening time would significantly increase the operation efficiency and hence gain the benefit of the regenerative technology.

Hassan, Mohamed I.; Al Kindi, Rashid

2014-08-01

234

A Regenerative High-Rise Tower in Shreveport, Louisiana  

E-print Network

by example the pedagogy of regenerative design. The 16-story structure — built in the 1950s and named the Petroleum Tower, reflecting the commodity that then ruled the local economy — was vacant and asbestos-laden when given to the non-profit Community...

Garrison, M.

235

Regenerative Wound Healing: The Role of Interleukin-10  

PubMed Central

Significance: Postnatal wounds heal with characteristic scar formation. In contrast, the mid-gestational fetus is capable of regenerative healing, which results in wound repair that is indistinguishable from uninjured skin. However, the underlying mechanisms of fetal regenerative phenotype are unknown. Recent Advances: The potent anti-inflammatory cytokine, interleukin-10 (IL-10), plays an essential role in the ability of the fetus to heal regeneratively and has been shown to recapitulate scarless healing in postnatal tissue. IL-10's ability to facilitate regenerative healing is likely a result of pleiotropic effects, through regulation of the inflammatory response, as well as novel roles as a regulator of the extracellular matrix, fibroblast cellular function, and endothelial progenitor cells. Overexpression of IL-10 using a variety of methods has been demonstrated to recapitulate the fetal regenerative phenotype in post-natal tissue, in conjunction with promising results of Phase II clinical trials using recombinant IL-10. Critical Issues: Successful wound healing is a complex process that requires coordination of multiple growth factors, cell types, and extracellular cellular matrix components. IL-10 has been demonstrated to be critical in the fetus' intrinsic ability to heal without scars, and, further, can induce scarless healing in postnatal tissue. The mechanisms through which IL-10 facilitates this regeneration are likely the result of IL-10's pleiotropic effects. Efforts to develop IL-10 as an anti-scarring agent have demonstrated promising results. Future Directions: Further studies on the delivery, including dose, route, and timing, are required in order to successfully translate these promising findings from in vitro studies and animal models into clinical practice. IL-10 holds significant potential as an anti-scarring therapeutic. PMID:24757588

King, Alice; Balaji, Swathi; Le, Louis D.; Crombleholme, Timothy M.; Keswani, Sundeep G.

2014-01-01

236

Serenoa repens for benign prostatic hyperplasia  

PubMed Central

Background Benign prostatic hyperplasia (BPH), a nonmalignant enlargement of the prostate, can lead to obstructive and irritative lower urinary tract symptoms (LUTS). The pharmacologic use of plants and herbs (phytotherapy) for the treatment of LUTS associated with BPH is common. The extract of the berry of the American saw palmetto, or dwarf palm plant, Serenoa repens (also known by its botanical name of Sabal serrulatum), is one of several phytotherapeutic agents available for the treatment of BPH. Objectives This systematic review aimed to assess the effects of Serenoa repens in the treatment of LUTS consistent with BPH. Search strategy Trials were searched in computerized general and specialized databases (MEDLINE, EMBASE, and The Cochrane Library), by checking bibliographies, and by handsearching the relevant literature. Selection criteria Trials were eligible if they (1) randomized men with symptomatic BPH to receive preparations of Serenoa repens (alone or in combination) for at least four weeks in comparison with placebo or other interventions, and (2) included clinical outcomes such as urologic symptom scales, symptoms, and urodynamic measurements. Eligibility was assessed by at least two independent observers. Data collection and analysis Information on patients, interventions, and outcomes was extracted by at least two independent reviewers using a standard form. The main outcome measure for comparing the effectiveness of Serenoa repens with placebo or other interventions was the change in urologic symptom-scale scores. Secondary outcomes included changes in nocturia and urodynamic measures. The main outcome measure for side effects or adverse events was the number of men reporting side effects. Main results In this update 9 new trials involving 2053 additional men (a 64.8% increase) have been included. For the main comparison - Serenoa repens versus placebo - 3 trials were added with 419 subjects and 3 endpoints (IPSS, peak urine flow, prostate size). Overall, 5222 subjects from 30 randomized trials lasting from 4 to 60 weeks were assessed. Twenty-six trials were double blinded and treatment allocation concealment was adequate in eighteen studies. Serenoa repens was not superior to placebo in improving IPSS urinary symptom scores, (WMD (weighted mean difference) ?0.77 points, 95% CI ?2.88 to 1.34, P > 0.05; 2 trials), finasteride (MD (mean difference) 0.40 points, 95% CI ?0.57 to 1.37, P > 0.05; 1 trial), or tamsulosin (WMD ?0.52 points, 95% CI ?1.91 to 0.88, P > 0.05; 2 trials). For nocturia, Serenoa repens was significantly better than placebo (WMD ?0.78 nocturnal visits, 95% CI ?1.34 to ?0.22, P < 0.05; 9 trials), but with the caveat of significant heterogeneity (I2 = 66%). A sensitivity analysis, utilizing higher quality, larger trials (? 40 subjects), demonstrated no significant difference (WMD ?0.31 nocturnal visits, 95% CI ?0.70 to 0.08, P > 0.05; 5 trials) (I2 = 11%). Serenoa repens was not superior to finasteride (MD ?0.05 nocturnal visits, 95% CI ?0.49 to 0.39, P > 0.05; 1 trial), or to tamsulosin (per cent improvement) (RR) (risk ratio) 0.91, 95% CI 0.66 to 1.27, P > 0.05; 1 trial). Comparing peak urine flow, Serenoa repens was not superior to placebo at trial endpoint (WMD 1.02 mL/s, 95% CI ?0.14 to 2.19, P > 0.05; 10 trials), or by comparing mean change (WMD 0.31 mL/s, 95% CI ?0.56 to 1.17, P > 0.05; 2 trials). Comparing prostate size at endpoint, there was no significant difference between Serenoa repens and placebo (MD ?1.05 cc, 95% CI ?8.84 to 6.75, P > 0.05; 2 trials), or by comparing mean change (MD ?1.22 cc, 95% CI ?3.91 to 1.47, P > 0.05; 1 trial). Authors’ conclusions Serenoa repens was not more effective than placebo for treatment of urinary symptoms consistent with BPH. PMID:19370565

Tacklind, James; MacDonald, Roderick; Rutks, Indy; Wilt, Timothy J

2011-01-01

237

Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages  

PubMed Central

Background Xenopus laevis has regenerative and non-regenerative stages. As a tadpole, it is fully capable of functional recovery after a spinal cord injury, while its juvenile form (froglet) loses this capability during metamorphosis. We envision that comparative studies between regenerative and non-regenerative stages in Xenopus could aid in understanding why spinal cord regeneration fails in human beings. Results To identify the mechanisms that allow the tadpole to regenerate and inhibit regeneration in the froglet, we obtained a transcriptome-wide profile of the response to spinal cord injury in Xenopus regenerative and non-regenerative stages. We found extensive transcriptome changes in regenerative tadpoles at 1 day after injury, while this was only observed by 6 days after injury in non-regenerative froglets. In addition, when comparing both stages, we found that they deployed a very different repertoire of transcripts, with more than 80% of them regulated in only one stage, including previously unannotated transcripts. This was supported by gene ontology enrichment analysis and validated by RT-qPCR, which showed that transcripts involved in metabolism, response to stress, cell cycle, development, immune response and inflammation, neurogenesis, and axonal regeneration were regulated differentially between regenerative and non-regenerative stages. Conclusions We identified differences in the timing of the transcriptional response and in the inventory of regulated transcripts and biological processes activated in response to spinal cord injury when comparing regenerative and non-regenerative stages. These genes and biological processes provide an entry point to understand why regeneration fails in mammals. Furthermore, our results introduce Xenopus laevis as a genetic model organism to study spinal cord regeneration. PMID:24885550

2014-01-01

238

Cytoplasmic immunoglobulins in giant lymph node hyperplasia (Castleman's tumour).  

PubMed

The immunohistologic features were studied in 6 cases of giant lymph node hyperplasia (GLNH) and the cytoplasmic immunoglobulin (CIg) characteristics were compared with those of follicular lymphoma and non-specific follicular lymph node hyperplasia. By use of the peroxidase - antiperoxidase (PAP) technique it was shown that GLNH comprised a mosaic, polyclonal population of CIG-producing cells, the CIg pattern being comparable with that observed in follicular lymphadenitis. In contrast, follicular lymphomas disclosed a definite monoclonal pattern, the cytoplasmic Ig containing only one light chain of kappa type. This led to the conclusion that GLNH is not a neoplastic change, but has the characteristics of a reactive process within the B-cell compartment. PMID:6119848

Dura, W T; Mioduszewska, O; Porwit-Ksiazek, A

1981-01-01

239

Impact of nonpenetrating clips on intimal hyperplasia of vascular anastomoses.  

PubMed

Non-penetrating, arcuate-legged titanium clips create an interrupted, non-penetrated, yet compliant vascular anastomoses that is associated with significantly reduced anastomotic neointimal hyperplasia. Recent experimental and clinical studies provide evidence that the non-suture alternative changes the biology of vessel-to-vessel and graft-to-vessel connections that reduces the stimulus for hyperplasia at a number of critical points in the response to injury schema. The compliant, "blood-tight" characteristics of clipped vascular reconstructions are associated with no endothelial injury or intraluminal foreign body, minimal platelet aggregation and laminal flow. Clinical applications including vascular access, femoropopliteal bypass, and closure of carotid endarterectomies are remarkable for the absence of restenosis and preserved anastomotic patency. PMID:11604335

Berman, S S; Kirsch, W M; Zhu, Y H; Anton, L; Chai, Y

2001-12-01

240

Clinical outcomes of childhood x-irradiation for lymphoid hyperplasia  

SciTech Connect

A prospective study was conducted to explore the relationship between childhood x-irradiation for lymphoid hyperplasia and the subsequent development of thyroid gland and other head and neck disorders. All individuals under 18 years of age who were x-irradiated for lymphoid hyperplasia during the years 1938-69 at Children's Hospital Medical Center, Boston comprised the exposed population. The comparison group consisted of non-exposed, surgically treated individuals. The study included a health questionnaire and a clinical examination component. A history of thyroid cancer was reported by 11 exposed subjects and no non-exposed subjects. Significantly elevated standardized incidence ratios of thyroid cancer were seen for both exposed males and females, 19.9 and 12.1, respectively. The average thyroid radiation dose was 25.8 rads and the mean latency period was 17.3 years.

Pottern, L.M.

1987-01-01

241

The significance of atypical lobular hyperplasia at percutaneous breast biopsy.  

PubMed

Atypical lobular hyperplasia (ALH) is occasionally found in specimens obtained by percutaneous stereotactic vacuum-assisted breast biopsy for microcalcifications. Since malignancy is often found at surgical excision when atypical ductal hyperplasia is found at percutaneous biopsy, we reviewed our pathologic findings from surgery for ALH at percutaneous biopsy. This was a retrospective review of all percutaneous breast biopsy specimens for mammographic microcalcifications obtained from a single institution over a 30-month period. The pathologic findings from percutaneous biopsy were correlated with the radiologic appearance and the pathology from surgical excision. ALH was found in 13 of 766 (1.7%) stereotactic vacuum-assisted core needle biopsies performed for mammographic microcalcifications. Subsequent surgery in six patients revealed ductal carcinoma in situ (DCIS) in two patients and one case of invasive ductal carcinoma. Surgical excision is indicated for areas with ALH discovered by percutaneous biopsy for mammographic microcalcifications. PMID:12558664

Dmytrasz, Karen; Tartter, Paul Ian; Mizrachy, Howard; Chinitz, Lynn; Rosenbaum Smith, Sharon; Estabrook, Alison

2003-01-01

242

Pictures of focal nodular hyperplasia and hepatocellular adenomas  

PubMed Central

This practical atlas aims to help liver and non liver pathologists to recognize benign hepatocellular nodules on resected specimen. Macroscopic and microscopic views together with immunohistochemical stains illustrate typical and atypical aspects of focal nodular hyperplasia and of hepatocellular adenoma, including hepatocellular adenomas subtypes with references to clinical and imaging data. Each step is important to make a correct diagnosis. The specimen including the nodule and the non-tumoral liver should be sliced, photographed and all different looking areas adequately sampled for paraffin inclusion. Routine histology includes HE, trichrome and cytokeratin 7. Immunohistochemistry includes glutamine synthase and according to the above results additional markers such as liver fatty acid binding protein, C reactive protein and beta catenin may be realized to differentiate focal nodular hyperplasia from hepatocellular adenoma subtypes. Clues for differential diagnosis and pitfalls are explained and illustrated.

Sempoux, Christine; Balabaud, Charles; Bioulac-Sage, Paulette

2014-01-01

243

New Advances in Benign Prostatic Hyperplasia: Laser Therapy  

Microsoft Academic Search

Throughout the past decade, numerous techniques for the treatment of benign prostatic hyperplasia have emerged. Laser therapy,\\u000a in particular, has gained widespread popularity among urologists. Since its inception in 1996, holmium laser enucleation of\\u000a the prostate (HoLEP) has been evaluated rigorously in the treatment of glands of all sizes. HoLEP has produced superior relief\\u000a of bladder outlet obstruction as compared

Jessica Mandeville; Ehud Gnessin; James E. Lingeman

2011-01-01

244

New laser treatment approaches for benign prostatic hyperplasia  

Microsoft Academic Search

The recent introduction of higher power 100 W holmium: yttrium-aluminum-garnet (Ho:YAG) and 80 W potassium titanyl phosphate\\u000a lasers for rapid incision and vaporization of the prostate has resulted in renewed interest in the use of lasers for treatment\\u000a of benign prostatic hyperplasia (BPH). Although long-term studies are still lacking, short-term results demonstrate that these\\u000a procedures are at least as safe

Nathaniel M. Fried

2007-01-01

245

Holmium Laser Approaches to Symptomatic Benign Prostatic Hyperplasia  

Microsoft Academic Search

The holmium laser is a well-established instrument in the treatment of a variety of urologic conditions. Treatment of benign\\u000a prostatic hyperplasia (BPH) with the holmium laser has grown steadily over the past decade, with multiple studies demonstrating\\u000a its role as an effective alternative to other transurethral and open surgical treatments of BPH. This review describes current\\u000a surgical techniques that employ

Andrew C. Boylan; Lori B. Lerner

246

Overview of interventional treatment options for benign prostatic hyperplasia  

PubMed Central

Transurethral resection of the prostate (TURP) remains the gold standard surgical intervention for men with benign prostatic hyperplasia (BPH). However, there are other, newer technologies that have also demonstrated safety and efficacy at least equivalent to that of TURP (e.g., Holmium laser, photoselective vaporization of the prostate). These minimally invasive techniques may be particularly useful for selected patient populations (e.g., those on anticoagulant therapy). PMID:23092781

Elhilali, Mostafa M.

2012-01-01

247

Regenerative Fuel Cell Test Rig at Glenn Research Center  

NASA Technical Reports Server (NTRS)

The regenerative fuel cell development effort at Glenn Research Center (GRC) involves the integration of a dedicated fuel cell and electrolyzer into an energy storage system test rig. The test rig consists of a fuel cell stack, an electrolysis stack, cooling pumps, a water transfer pump, gas recirculation pumps, phase separators, storage tanks for oxygen (O2) and hydrogen (H2), heat exchangers, isolation valves, pressure regulators, interconnecting tubing, nitrogen purge provisions, and instrumentation for control and monitoring purposes. The regenerative fuel cell (RFC) thus formed is a completely closed system which is capable of autonomous cyclic operation. The test rig provides direct current (DC) load and DC power supply to simulate power consumption and solar power input. In addition, chillers are used as the heat sink to dissipate the waste heat from the electrochemical stack operation. Various vents and nitrogen (N2) sources are included in case inert purging is necessary to safe the RFC test rig.

Chang, Bei-Jiann; Johnson, Donald W.; Garcia, Christopher P.; Jakupca, Ian J.; Scullin, Vincent J.; Bents, David J.

2003-01-01

248

High-precision buffer circuit for suppression of regenerative oscillation  

NASA Technical Reports Server (NTRS)

Precision analog signal conditioning electronics have been developed for wind tunnel model attitude inertial sensors. This application requires low-noise, stable, microvolt-level DC performance and a high-precision buffered output. Capacitive loading of the operational amplifier output stages due to the wind tunnel analog signal distribution facilities caused regenerative oscillation and consequent rectification bias errors. Oscillation suppression techniques commonly used in audio applications were inadequate to maintain the performance requirements for the measurement of attitude for wind tunnel models. Feedback control theory is applied to develop a suppression technique based on a known compensation (snubber) circuit, which provides superior oscillation suppression with high output isolation and preserves the low-noise low-offset performance of the signal conditioning electronics. A practical design technique is developed to select the parameters for the compensation circuit to suppress regenerative oscillation occurring when typical shielded cable loads are driven.

Tripp, John S.; Hare, David A.; Tcheng, Ping

1995-01-01

249

Regenerative medicine for congenital diaphragmatic hernia: regeneration for repair.  

PubMed

Regenerative medicine has developed recently as a new field of science aiming at restoring organ and tissue damage through the use of autologous constructs. Cellular therapies and relatively simple tissue engineering reconstructions have recently been successfully applied into patients. For babies born with congenital diaphragmatic hernia, regenerative medicine may play a role both in developing a myogenic patch capable of restoring muscle function and promoting regeneration of hypoplastic lungs that characterised those patients. The latter is particularly attractive because it may change the long-term outcome of those children. We aim here to discuss recent advancement in the field, looking in particular at the future clinical prospective of those exciting therapeutic strategies. PMID:23114980

De Coppi, Paolo; Deprest, Jan

2012-10-01

250

Investigation of electroforming techniques. [fabrication of regeneratively cooled thrust chambers  

NASA Technical Reports Server (NTRS)

Copper and nickel electroforming was examined for the purpose of establishing the necessary processes and procedures for repeatable, successful fabrication of the outer structures of regeneratively cooled thrust chambers. The selection of electrolytes for copper and nickel deposition is described. The development studies performed to refine and complete the processes necessary for successful chamber shell fabrication and the testing employed to verify the applicability of the processes and procedures to small scale hardware are described. Specifications were developed to afford a guideline for the electroforming of high quality outer shells on regeneratively cooled thrust chamber liners. Test results indicated repeatable mechanical properties could be produced in copper deposits from the copper sulfate electrolyte with periodic current reversal and in nickel deposits from the sulfamate solution. Use of inert, removable channel fillers and the conductivizing of such is described. Techniques (verified by test) which produce high integrity bonds to copper and copper alloy liners are discussed.

Malone, G. A.

1975-01-01

251

Seikan tunnel electric train propulsion -- Regenerative energy management  

SciTech Connect

The mission was to model the electric propulsion and regenerative energy requirements for the Kaikyo passenger train and the Kamotsusen freight train system currently operating between Tappikaitei and Yoshiokakaitei through the Seikan tunnel under the Pacific Ocean. The Seikan tunnel is over 54 km in length and connects Aomori on the main Japanese island of Honshu to the North island of Hokkaido. Further, over 24 km of the Seikan tunnel is 100 meters below the sea bed of the Tsugaru Strait which joins the Pacific with the Sea of Japan. While, the sea bed is 140 meters below the mean Pacific sea level, at the deepest point. Safety and energy conservation issues led to reliable regenerative energy recovery and braking systems.

Isshiki, Seita [Ashikaga Inst. of Tech., Tokyo (Japan); Wyczalek, F.A. [FW Lilly Inc., Bloomfield, Hills, MI (United States)

1997-12-31

252

Regenerative medicine for the kidney: stem cell prospects & challenges  

PubMed Central

The kidney has key roles in maintaining human health. There is an escalating medical crisis in nephrology as growing numbers of patients suffer from kidney diseases that culminate in organ failure. While dialysis and transplantation provide life-saving treatments, these therapies are rife with limitations and place significant burdens on patients and healthcare systems. It has become imperative to find alternative ways to treat existing kidney conditions and preemptive means to stave off renal dysfunction. The creation of innovative medical approaches that utilize stem cells has received growing research attention. In this review, we discuss the regenerative and maladaptive cellular responses that occur during acute and chronic kidney disease, the emerging evidence about renal stem cells, and some of the issues that lie ahead in bridging the gap between basic stem cell biology and regenerative medicine for the kidney. PMID:23688352

2013-01-01

253

Cell sheet approach for tissue engineering and regenerative medicine.  

PubMed

After the biotech medicine era, regenerative medicine is expected to be an advanced medicine that is capable of curing patients with difficult-to-treat diseases and physically impaired function. Our original scaffold-free cell sheet-based tissue engineering technology enables transplanted cells to be engrafted for a long time, while fully maintaining their viability. This technology has already been applied to various diseases in the clinical setting, including the cornea, esophagus, heart, periodontal ligament, and cartilage using autologous cells. Transplanted cell sheets not only replace the injured tissue and compensate for impaired function, but also deliver growth factors and cytokines in a spatiotemporal manner over a prolonged period, which leads to promotion of tissue repair. Moreover, the integration of stem cell biology and cell sheet technology with sufficient vascularization opens possibilities for fabrication of human three-dimensional vascularized dense and intact tissue grafts for regenerative medicine to parenchymal organs. PMID:24858800

Matsuura, Katsuhisa; Utoh, Rie; Nagase, Kenichi; Okano, Teruo

2014-09-28

254

Spacecraft Radiator Freeze Protection Using a Regenerative Heat Exchanger  

NASA Technical Reports Server (NTRS)

An active thermal control system architecture has been modified to include a regenerative heat exchanger (regenerator) inboard of the radiator. Rather than using a radiator bypass valve a regenerative heat exchanger is placed inboard of the radiators. A regenerator cold side bypass valve is used to set the return temperature. During operation, the regenerator bypass flow is varied, mixing cold radiator return fluid and warm regenerator outlet fluid to maintain the system setpoint. At the lowest heat load for stable operation, the bypass flow is closed off, sending all of the flow through the regenerator. This lowers the radiator inlet temperature well below the system set-point while maintaining full flow through the radiators. By using a regenerator bypass flow control to maintain system setpoint, the required minimum heat load to avoid radiator freezing can be reduced by more than half compared to a radiator bypass system.

Ungar, Eugene K.; Schunk, Richard G.

2011-01-01

255

Regenerative medicine for the kidney: stem cell prospects & challenges.  

PubMed

The kidney has key roles in maintaining human health. There is an escalating medical crisis in nephrology as growing numbers of patients suffer from kidney diseases that culminate in organ failure. While dialysis and transplantation provide life-saving treatments, these therapies are rife with limitations and place significant burdens on patients and healthcare systems. It has become imperative to find alternative ways to treat existing kidney conditions and preemptive means to stave off renal dysfunction. The creation of innovative medical approaches that utilize stem cells has received growing research attention. In this review, we discuss the regenerative and maladaptive cellular responses that occur during acute and chronic kidney disease, the emerging evidence about renal stem cells, and some of the issues that lie ahead in bridging the gap between basic stem cell biology and regenerative medicine for the kidney. PMID:23688352

Li, Yue; Wingert, Rebecca A

2013-01-01

256

The theory of an active magnetic regenerative refrigerator  

NASA Technical Reports Server (NTRS)

The adiabatic temperature change with field which is limited to about 2 K/Tesla for ferromagnets near their Curie temperatures by the change of magnetization with temperature and the lattice heat capacity is discussed. Practical magnetic refrigerators operate on a regenerative cycle such as the Brayton cycle. This cycle can be executed through the use of an active magnetic regenerator, i.e., a regenerator composed of magnetic material that is cycled in an out of a magnetic field with appropriate fluid flows. The theory of these devices is predicted by solving the partial differential equations that describe fluid and the magnetic solid. The active magnetic regenerator is described along with the method of calculation. Temperature profiles for a normal regenerator and a magnetic regenerative refrigerator are shown.

Barclay, J. A.

1983-01-01

257

Hot spot liver scan in focal nodular hyperplasia  

SciTech Connect

In scintigraphy of the liver with radiocolloid, space-occupying lesions generally are visualized as regions of decreased accumulation of radioactivity. Rarely focal areas of increased activity are depicted; most are related to altered vascular dynamics in the liver secondary to obstruction of the superior or inferior vena cava or the hepatic veins. There are reports of single cases of focally increased activity due to a hepatic hemangioma, hepatic venoocclusive disease, herniation of a part of the liver, and a liver hot spot found after radiocolloid injection via a malpositioned central venous catheter in one of the hepatic vein branches. In patients with focal nodular hyperplasia, liver scans with solitary defects as well as normal patterns are found. In some cases, increased uptake of colloid in the lesion has been documented. Pasquier and Dorta reported a patient with a palpable mass in the left liver lobe with increased accumulation of radioactivity on the radiocolloid liver scan. The histologic diagnosis was hamartoma, but reviewing the description and considering the confusion in the past concerning the nomenclature, this case is suggestive of focal nodular hyperplasia. We report a patient with focal nodular hyperplasia who had increased radiocolloid uptake in the lesion. The radionuclide studies are compared with angiography, sonography, and computed tomography. An explanation for the localized increased colloid accumulation based on histologic findings is suggested.

Piers, D.A. (Univ. Hospital, Groningen, Netherlands); Houthoff, H.J.; Krom, R.A.F.; Schuur, K.H.; Sikkens, H.; Weits, J.

1980-12-01

258

Two-tier regenerative response in liver failure in humans.  

PubMed

Acute and chronic liver failure is associated with high mortality. The enormous regenerative potential of the liver has generated a lot of attention. We undertook this work to assess the two-tier regenerative response in liver failure by immunohistochemistry and to correlate such response with liver histology in acute liver failure (ALF), acute-on-chronic liver failure (ACLF), and decompensated cirrhosis (CHD). Histological examination and immunohistochemical analysis of proliferating hepatocytes and activated hepatic progenitor cells (HPCs) were performed on the liver tissue of patients with ALF (25), ACLF (70), and CHD (70). Comparative analysis of regenerative markers and correlation with histological parameters were done in ALF, ACLF, and CHD. Hepatocytes proliferated significantly more in ALF in comparison to ACLF (p?regenerative potential in ACLF. PMID:24590583

Rastogi, Archana; Maiwall, Rakhi; Bihari, Chhagan; Trehanpati, Nirupma; Pamecha, Viniyendra; Sarin, Shiv Kumar

2014-05-01

259

The Application of Microwave Incineration to Regenerative Life Support  

NASA Technical Reports Server (NTRS)

Future human exploration missions will require life support systems that are highly regenerative, requiring minimum resupply, enabling the crews to be largely self-sufficient. Solid wastes generated in space will be processed to recover usable material. Researchers at NASA Ames Research Center are studying a commercially-produced microwave incinerator as a solid waste processor. This paper will describe the results of testing to-date.

Sun, Sidney C.; Srinivasan, Venkatesh; Covington, Al (Technical Monitor)

1995-01-01

260

Testing a Regenerative Carbon Dioxide and Moisture Removal Technology  

Microsoft Academic Search

The National Aeronautics and Space Administration supported the development of a new vacuum-desorbed regenerative carbon dioxide and humidity control technology for use in short duration human spacecraft. The technology was baselined for use in the Orion Crew Exploration Vehicle's Environmental Control and Life Support System (ECLSS). Termed the Carbon Diox-ide And Moisture Removal Amine Swing-bed (CAMRAS), the unit was developed

Daniel J. Barta; Amy Button; Jeffrey Sweterlitsch; Suzanne Curley

2010-01-01

261

Regenerative gas turbine with thermal-energy conservation  

Microsoft Academic Search

A thermal-energy conservation system for a regenerative gas turbine, and preferably a highly-regenerated high-temperature two-shaft gas-turbine engine, operating at an equilibrium temperature is provided. The gas-turbine engine includes a compressor, a combustor, a fuel throttle, a turbine, and a regenerator which transfers thermal energy from the heated exhaust gases of the turbine to the compressed air delivered to the combustor.

Best

1982-01-01

262

A graphite-lined regeneratively cooled thrust chamber  

NASA Technical Reports Server (NTRS)

Design concepts, based on use of graphite as a thermal barrier for regeneratively cooled FLOX-methane thrust chambers, have been screened and concepts selected for detailed thermodynamic, stress, and fabrication analyses. A single design employing AGCarb-101, a fibrous graphite composite material, for a thermal barrier liner and an electroformed nickel structure with integral coolant passages was selected for fabrication and testing. The fabrication processes and the test results are described and illustrated.

Stubbs, V. R.

1972-01-01

263

Hydrogen-Oxygen PEM Regenerative Fuel Cell Energy Storage System  

NASA Technical Reports Server (NTRS)

An introduction to the closed cycle hydrogen-oxygen polymer electrolyte membrane (PEM) regenerative fuel cell (RFC), recently constructed at NASA Glenn Research Center, is presented. Illustrated with explanatory graphics and figures, this report outlines the engineering motivations for the RFC as a solar energy storage device, the system requirements, layout and hardware detail of the RFC unit at NASA Glenn, the construction history, and test experience accumulated to date with this unit.

Bents, David J.; Scullin, Vincent J.; Chang, Bei-Jiann; Johnson, Donald W.; Garcia, Christopher P.

2005-01-01

264

Tissue engineering and regenerative medicine research perspectives for pediatric surgery  

Microsoft Academic Search

Tissue engineering and regenerative medicine research is being aggressively pursued in attempts to develop biological substitutes\\u000a to replace lost tissue or organs. Remarkable degrees of success have been achieved in the generation of a variety of tissues\\u000a and organs as a result of concerted contributions by multidisciplinary groups in the field of biotechnology. Engineering of\\u000a an organ is a complex

Amulya K. Saxena

2010-01-01

265

The Ovonic Regenerative Fuel Cell, A Fundamentally New Approach  

NSDL National Science Digital Library

This report introduces the Ovonic Regenerative fuel cell, which is a technology that "utilizes Ovonic metal hydride materials in place of traditional noble metal catalysts in the hydrogen fuel electrode." The paper goes into detail about how these fuel cells work and includes graphical representations of the processes involved. This paper was presented at the Hydrogen and Fuel Cells 2004 Conference and Trade Show in Toronto, Canada. This document may be downloaded in PDF file format.

Corrigan, D. A.; Ovshinsky, S. R.; Venkatesan, S.

2012-08-24

266

Power conditions and control of a regenerative brake  

Microsoft Academic Search

Braking capability is typically accomplished by adding a dynamic\\/resistive brake (DB) module to a standard drive. Regenerating energy is dissipated in the braking resistor creating heat and decreasing the overall efficiency of the drive. To overcome the shortcomings of the DB solution, a regenerative brake (RB) was developed. The RB is a stand-alone, add-on unit to the drive. It operates

Vladimir Blasko

1998-01-01

267

Potential regenerative treatment strategies for intervertebral disc degeneration in dogs  

PubMed Central

Pain due to spontaneous intervertebral disc (IVD) disease is common in dogs. In chondrodystrophic (CD) dogs, IVD disease typically develops in the cervical or thoracolumbar spine at about 3–7 years of age, whereas in non-chondrodystrophic (NCD) dogs, it usually develops in the caudal cervical or lumbosacral spine at about 6–8 years of age. IVD degeneration is characterized by changes in the biochemical composition and mechanical integrity of the IVD. In the degenerated IVD, the content of glycosaminoglycan (GAG, a proteoglycan side chain) decreases and that of denatured collagen increases. Dehydration leads to tearing of the annulus fibrosus (AF) and/or disc herniation, which is clinically characterized by pain and/or neurological signs. Current treatments (physiotherapy, anti-inflammatory/analgesic medication, surgery) for IVD disease may resolve neurological deficits and reduce pain (although in many cases insufficient), but do not lead to repair of the degenerated disc. For this reason, there is interest in new regenerative therapies that can repair the degenerated disc matrix, resulting in restoration of the biomechanical function of the IVD. CD dogs are considered a suitable animal model for human IVD degeneration because of their spontaneous IVD degeneration, and therefore studies investigating cell-, growth factor-, and/or gene therapy-based regenerative therapies with this model provide information relevant to both human and canine patients. The aim of this article is to review potential regenerative treatment strategies for canine IVD degeneration, with specific emphasis on cell-based strategies. PMID:24387033

2014-01-01

268

Regenerative medicine in Europe: global competition and innovation governance.  

PubMed

Leading European nations with strong biotech sectors, such as the UK and Germany, are investing heavily in regenerative medicine, seeking competitive advantage in this emerging sector. However, in the broader biopharmaceutical sector, the EU is outperformed by the USA on all metrics, reflecting longstanding problems: limited venture capital finance, a fragmented patent system, and relatively weak relations between academia and industry. The current global downturn has exacerbated these difficulties. The crisis comes at a time when the EU is reframing its approach to the governance of innovation and renewing its commitment to the goal of making Europe the leading player in the global knowledge economy. If the EU is to gain a competitive advantage in the regenerative medicine sector then it must coordinate a complex multilevel governance framework that encompasses the EU, member states and regional authorities. This article takes stock of Europe's current competitive position within the global bioeconomy, drawing on a variety of metrics in the three intersecting spheres of innovation governance: science, market and society. These data then provide a platform for reviewing the problems of innovation governance faced by the EU and the strategic choices that have to be confronted in the regenerative medicine sector. PMID:21082895

Hogarth, Stuart; Salter, Brian

2010-11-01

269

Leptin Effects on the Regenerative Capacity of Human Periodontal Cells  

PubMed Central

Obesity is increasing throughout the globe and characterized by excess adipose tissue, which represents a complex endocrine organ. Adipose tissue secrets bioactive molecules called adipokines, which act at endocrine, paracrine, and autocrine levels. Obesity has recently been shown to be associated with periodontitis, a disease characterized by the irreversible destruction of the tooth-supporting tissues, that is, periodontium, and also with compromised periodontal healing. Although the underlying mechanisms for these associations are not clear yet, increased levels of proinflammatory adipokines, such as leptin, as found in obese individuals, might be a critical pathomechanistic link. The objective of this study was to examine the impact of leptin on the regenerative capacity of human periodontal ligament (PDL) cells and also to study the local leptin production by these cells. Leptin caused a significant downregulation of growth (TGF?1, and VEGFA) and transcription (RUNX2) factors as well as matrix molecules (collagen, and periostin) and inhibited SMAD signaling under regenerative conditions. Moreover, the local expression of leptin and its full-length receptor was significantly downregulated by inflammatory, microbial, and biomechanical signals. This study demonstrates that the hormone leptin negatively interferes with the regenerative capacity of PDL cells, suggesting leptin as a pathomechanistic link between obesity and compromised periodontal healing. PMID:25136363

Nokhbehsaim, Marjan; Keser, Sema; Jager, Andreas; Jepsen, S?ren; Bourauel, Christoph

2014-01-01

270

Unitized Regenerative Fuel Cell System Dryer-Humidifier Analytical Model Development  

NASA Technical Reports Server (NTRS)

A Unitized Regenerative Fuel Cell (URFC) Energy Storage System is being developed at the NASA Glenn Research Center. This URFC system is unique in that it uses regenerative gas dryers/humidifiers that are mounted on the surface of the gas storage tanks that act as the radiators for thermal control of the URFC system. As the gas storage tanks cool down during URFC charging the regenerative gas dryers/humidifiers dry the hydrogen and oxygen gases produced by electrolysis. As the gas storage tanks heat up during URFC discharging, the regenerative gas dryers/humidifiers humidify the hydrogen and oxygen gases used by fuel cell. An analytical model was developed to simulate the URFC system's regenerative gas dryers/humidifiers. The model is in the form of an EXCEL@ worksheet that allows the investigation of the regenerative gas dryers/humidifier performance as a function of time and position within the regenerative gas dryers/humidifiers, as well as other key system variables. Finite Element Analysis (FEA) modeling of the regenerative gas dryers/humidifier and gas storage tank wall was also done to analyze spatial temperature distribution within the regenerative gas dryers/humidifiers and the localized tank wall. Test results obtained from the testing of the regenerative gas dryers/humidifiers in a thermal vacuum environment were used to corroborate the analyses.

Burke, Kenneth A.; Jakupca, Ian

2003-01-01

271

Hyperplasia of the mandibular body: An anomaly in a developmental anomaly.  

PubMed

Hyperplasias of the mandible are usually seen in relation to the condyle or affecting one half of the mandible, such cases being described as hemimandibular hyperplasia or elongation. This article presents a rare case of hyperplasia of the right body of the mandible. The case being unique in that although being present from childhood did not cause any functional disturbances or any occlusal disharmony characteristically seen in such developmental anomalies. Here, we describe the clinical, radiographic and histopathologic findings that led to the diagnosis hyperplasia of the mandibular body and the treatment rendered to provide the esthetic correction. PMID:23956592

Ravi, Vaiyapuri; Srinivasan, Saravanan; Jacob, Mathew; Kesavan, Priya; Palani, Rajathi; Balakrishnan, Sekar

2013-07-01

272

The Functional Role of Reactive Stroma in Benign Prostatic Hyperplasia  

PubMed Central

The human prostate gland is one of the only internal organs that continue to enlarge throughout adulthood. The specific mechanisms that regulate this growth, as well as the pathological changes leading to the phenotype observed in the disease benign prostatic hyperplasia (BPH), are essentially unknown. Recent studies and their associated findings have made clear that many complex alterations occur, involving persistent and chronic inflammation, circulating hormonal level deregulation, and aberrant wound repair processes. BPH has been etiologically characterized as a progressive, albeit discontinuous, hyperplasia of both the glandular epithelial and stromal cell compartments coordinately yielding an expansion of the prostate gland and clinical symptoms. Interestingly, the inflammatory and repair responses observed in BPH are also key components of general wound repair in post-natal tissues. These responses include altered expression of chemokines, cytokines, matrix remodeling factors, chronic inflammatory processes, altered immune surveillance and recognition, as well as the formation of a prototypical ‘reactive’ stroma which is similar to that observed across various fibroplasias and malignancies of a variety of tissue sites. Stromal tissue, both embryonic mesenchyme, and adult reactive stroma myofibroblasts, has been shown to exert potent and functional regulatory control over epithelial proliferation and differentiation as well as immunoresponsive modulation. Thus, the functional biology of a reactive stroma, within the context of an adult disease typified by epithelial and stromal aberrant hyperplasia, is critical to understand within the context of prostate disease and beyond. The mechanisms that regulate reactive stroma biology in BPH represent targets of opportunity for new therapeutic approaches that may extend to other tissue contexts. Accordingly, this review seeks to address the dissection of important factors, signaling pathways, genes, and other regulatory components that mediate the interplay between epithelium and stromal responses in BPH. PMID:21664759

Schauer, Isaiah G.; Rowley, David R.

2011-01-01

273

Neointimal hyperplasia associated with the use of u-clip.  

PubMed

The U-Clip (Coalescent Surgical, Sunnydale, CA USA) allows the surgeon to create an interrupted anastomosis in the same amount of time that is required for a continuous anastomosis with the elimination of knotting. Its use is indicated especially in minimally invasive surgery. We describe a case of a patient in which the proximal anastomosis was performed by interrupted suture with Coalescent U-Clip anastomotic device. Six months later, he presented with stenosis of the anastomosis, and intravascular ultrasound showed anastomotic neointimal hyperplasia. PMID:22437642

Melero, Jose Maria; Di Stefano, Salvatore; Porras, Carlos; Alonso, Juan; Sánchez, Gemma; Such, Miguel; Olalla, Eduardo

2010-11-01

274

Epithelioid hemangioma of the orbit or angiolymphoid hyperplasia with eosinophilia.  

PubMed

A patient was referred to the department for an incidentally discovered right orbital mass on MRI. After surgical excision, histopathologic examination led to the diagnosis of epithelioid hemangioma, a tumor rarely located in the orbit, whose main histopathologic feature is an exuberant proliferation of small vascular channels lined by enlarged endothelial cells. The clinical characteristics and histopathology of epithelioid hemangioma allow differentiation with Kimura disease, angiosarcoma, intravascular papillary endothelial hyperplasia, and other vascular tumors that share the common feature of an abnormal proliferation of endothelial cells. Although epithelioid hemangioma is extremely rare, it should be considered in the differential diagnosis of orbital tumors. PMID:24026000

Sánchez-Orgaz, Margarita; Insausti-García, Alfredo; Gregorio, Laura Yébenes; Duralde, Alvaro Arbizu; Romero-Martín, Ricardo

2014-01-01

275

Giant lymph node hyperplasia: persistence of symptoms for 15 years  

SciTech Connect

A woman with giant lymph node hyperplasia of the mediastinum and systemic symptoms was treated with radiotherapy. Following a short partial remission, symptoms have persisted for 15 years. Surgical excision remains the treatment of choice, although the failure of radiotherapy may be due to inadequate dosage. If symptoms persist after treatment, a diagnosis of multicentric disease should be excluded. Review of histologic material may be helpful in puzzling clinical cases, as shown by the establishment of the diagnosis in this patient 13 years after the onset of symptoms.

Moir, D.H.; Choy, T.; Dalton, W.R.

1982-02-15

276

Sporadic adrenomedullary hyperplasia with hypertension— Clinicomorphological entity or coincidence?  

Microsoft Academic Search

Background\\u000a \\u000a Sporadic adrenomedullary hyperplasia (AMH) is characterized by 1) clinical history of hypertension, 2) lack of association\\u000a with Multiple Endocrine Neoplasia syndromes, 3) increased urinary and\\/or serum catecholamine concentrations, and 4) histomorphometric\\u000a evidence of increased medullary cell mass.\\u000a \\u000a \\u000a \\u000a Methods\\u000a \\u000a \\u000a This study presents the clinicomorphologic findings of 10 own cases of sporadic AMH and 12 additional cases reported in the\\u000a literature

H. Dralle; S. Schröder; T. Schiirmeyet; K. F. Gratz; R. Grote

1993-01-01

277

Effects of pulsed electromagnetic fields on benign prostate hyperplasia  

Microsoft Academic Search

Introduction  Benign prostate hyperplasia (BPH) has been treated with various types of electromagnetic radiation methods such as transurethral\\u000a needle ablation (TUNA), interstitial laser therapy (ILC), holmium laser resection (HoLRP). In the present study, the effects\\u000a of a noninvasive method based on the exposure of patients with BPH to a pulsative EM Field at radiofrequencies have been investigated.\\u000a \\u000a \\u000a \\u000a \\u000a Materials and methods  Twenty patients

Xenophon K. Giannakopoulos; Christos Giotis; Spyridon Ch. Karkabounas; Ioannis I. Verginadis; Yannis V. Simos; Dimitrios Peschos; Angelos M. Evangelou

278

Integration of regenerative shock absorber into vehicle electric system  

NASA Astrophysics Data System (ADS)

Regenerative/Energy harvesting shock absorbers have a great potential to increase fuel efficiency and provide suspension damping simultaneously. In recent years there's intensive work on this topic, but most researches focus on electricity extraction from vibration and harvesting efficiency improvement. The integration of electricity generated from regenerative shock absorbers into vehicle electric system, which is very important to realize the fuel efficiency benefit, has not been investigated. This paper is to study and demonstrate the integration of regenerative shock absorber with vehicle alternator, battery and in-vehicle electrical load together. In the presented system, the shock absorber is excited by a shaker and it converts kinetic energy into electricity. The harvested electricity flows into a DC/DC converter which realizes two functions: controlling the shock absorber's damping and regulating the output voltage. The damping is tuned by controlling shock absorber's output current, which is also the input current of DC/DC converter. By adjusting the duty cycles of switches in the converter, its input impedance together with input current can be adjusted according to dynamic damping requirements. An automotive lead-acid battery is charged by the DC/DC converter's output. To simulate the working condition of combustion engine, an AC motor is used to drive a truck alternator, which also charges the battery. Power resistors are used as battery's electrical load to simulate in-vehicle electrical devices. Experimental results show that the proposed integration strategy can effectively utilize the harvested electricity and power consumption of the AC motor is decreased accordingly. This proves the combustion engine's load reduction and fuel efficiency improvement.

Zhang, Chongxiao; Li, Peng; Xing, Shaoxu; Kim, Junyoung; Yu, Liangyao; Zuo, Lei

2014-03-01

279

Regenerative thermal oxidation for non-conventional applications  

SciTech Connect

Regenerative Thermal Oxidation has been applied by Biothermica to treat non-conventional emissions. These emissions include pollutants as VOC, COC, TRS, PAH, PCB, HCl and odors. In the kraft pulping industry, environmental requirements for reduced emissions of total reduced sulfur (TRS) and volatile organic compounds (VOC) from pulping operations are leading to incinerators of high destruction efficiency and thermal performance. The first installation in Canada of a Regenerative Thermal Oxidation (RTO) was placed in service early in 1997 at a kraft pulp mill in the province of Quebec. Tests have shown a TRS reduction of 99.6% with a thermal efficiency of 88.5% in the RTO. It can be considered the best method to comply with the new norms for TRS atmospheric emissions in the pulp and paper industry. In the primary aluminum process, a marked improvement in anode properties can be gained by preparing the paste at high temperature, followed by cooling with a water addition in an intensive mixer. However, the addition of cooling water results in a large increase in the emissions of VOC and PAH which can prejudice the process. A number of emission control processes were evaluated. An improved Regenerative Thermal Oxidation (RTO) unit was installed in a modern aluminum plant in Canada. The emissions of VOCs and PAHs from an EIRICH intensive mixer-cooler were reduced by more than 99.9% while all troublesome deposits in the fumes collection system were eliminated. This enabled the plant to remain well within the emission levels allowed by the environmental authority while enjoying considerable benefits from improved anode qualities. In the asphalt roofing industry, RTO was applied to treat the VOC and COC emissions and several units have been in operation since 1990. In the United States two units were installed in asphalt shingle plants and new features in the process show a VOC and COC reduction of 99%.

Gosselin, G.; Gravel, J.J.O.

1999-07-01

280

Theoretical and experimental study on regenerative rotary displacer Stirling engine  

SciTech Connect

Recently a quite new type of hot air engine called rotary displacer engine, in which the displacer is a rotating disk enclosed in a cylinder, has been conceived and developed. The working gas, contained in a notch excavated in the disk, is heated and cooled alternately, on account of the heat transferred through the enclosing cylinder that is heated at one side and cooled at the opposite one. The gas temperature oscillations cause the pressure fluctuations that get out mechanical power acting on a power piston. In order to attempt to increase the performances for this kind of engine, the authors propose three different regeneration methods. The first one comprises two coaxial disks that, revolving in opposite ways, cause a temperature gradient on the cylinder wall and a regenerative axial heat conduction through fins shaped on the cylinder inner wall. The other two methods are based on the heat transferred by a proper closed circuit that in one case has a circulating liquid inside and in the other one is formed by several heat pipes working each one for different temperatures. An engine based on the first principle, the Regenerative Tandem Contra-Rotary Displacer Stirling Engine, has been realized and experimented. In this paper experimental results with and without regeneration are reported comparatively with a detailed description of the unity. A basic explanation of the working principle of this engine and a theoretical analysis investigating the main influential parameters for the regenerative effect are done. This new rotating displacer Stirling engines, for their simplicity, are expected to attain high rotational speed especially for applications as demonstration and hobby unities.

Raggi, L.; Katsuta, Masafumi [Waseda Univ., Tokyo (Japan); Isshiki, Naotsugu [Nihon Univ., Tokyo (Japan); Isshiki, Seita [Isshiki R and D Lab., Tokyo (Japan)

1997-12-31

281

New approach in dynamics of regenerative chatter research of turning  

NASA Astrophysics Data System (ADS)

In this paper, regenerative chatter phenomena in a turning process is discussed from impulsive dynamical point of view. By introducing the instantaneous pulse when vibration occurs and the vibratory condition set, we optimize the models and present a certain kind of second-order impulsive differential systems, which is a specific discontinuous dynamical system. Then we search for the general results of the nonoccurrence of chatter phenomena by discussing the number of the vibration pulse times, utilizing the method of flow theory in discontinuous systems and transversal property at the boundary. Our results give a convenient way to estimate the available parameters to keep the turning process stable.

Fu, Xilin; Zheng, Shasha

2014-11-01

282

Complement-triggered pathways orchestrate regenerative responses throughout phylogenesis  

PubMed Central

Adult tissue plasticity, cell reprogramming, and organ regeneration are major challenges in the field of modern regenerative medicine. Devising strategies to increase the regenerative capacity of tissues holds great promise for dealing with donor organ shortages and low transplantation outcomes and also provides essential impetus to tissue bioengineering approaches for organ repair and replacement. The inherent ability of cells to reprogram their fate by switching into an embryonic-like, pluripotent progenitor state is an evolutionary vestige that in mammals has been retained mostly in fetal tissues and persists only in a few organs of the adult body. Tissue regeneration reflects the capacity of terminally differentiated cells to re-enter the cell cycle and proliferate in response to acute injury or environmental stress signals. In lower vertebrates, this regenerative capacity extends to several organs and remarkably culminates in precise tissue patterning, through cellular transdifferentiation and complex morphogenetic processes that can faithfully reconstruct entire body parts. Many lessons have been learned from robust regeneration models in amphibians such as the newt and axolotl. However, the dynamic interactions between the regenerating tissue, the surrounding stroma, and the host immune response, as it adapts to the actively proliferating tissue, remain ill-defined. The regenerating zone, through a sequence of distinct molecular events, adopts phenotypic plasticity and undergoes rigorous tissue remodeling that, in turn, evokes a significant inflammatory response. Complement is a primordial sentinel of the innate immune response that engages in multiple inflammatory cascades as it becomes activated during tissue injury and remodeling. In this respect, complement proteins have been implicated in tissue and organ regeneration in both urodeles and mammals. Distinct complement-triggered pathways have been shown to modulate critical responses that promote tissue reprogramming, pattern formation, and regeneration across phylogenesis. This article will discuss the mechanistic insights underlying the crosstalk of complement with cytokine and growth factor signaling pathways that drive tissue regeneration and will provide a unified conceptual framework for considering complement modulation as a novel target for regenerative therapeutics. PMID:23684626

Mastellos, Dimitrios C.; DeAngelis, Robert A.; Lambris, John D.

2014-01-01

283

Complement-triggered pathways orchestrate regenerative responses throughout phylogenesis.  

PubMed

Adult tissue plasticity, cell reprogramming, and organ regeneration are major challenges in the field of modern regenerative medicine. Devising strategies to increase the regenerative capacity of tissues holds great promise for dealing with donor organ shortages and low transplantation outcomes and also provides essential impetus to tissue bioengineering approaches for organ repair and replacement. The inherent ability of cells to reprogram their fate by switching into an embryonic-like, pluripotent progenitor state is an evolutionary vestige that in mammals has been retained mostly in fetal tissues and persists only in a few organs of the adult body. Tissue regeneration reflects the capacity of terminally differentiated cells to re-enter the cell cycle and proliferate in response to acute injury or environmental stress signals. In lower vertebrates, this regenerative capacity extends to several organs and remarkably culminates in precise tissue patterning, through cellular transdifferentiation and complex morphogenetic processes that can faithfully reconstruct entire body parts. Many lessons have been learned from robust regeneration models in amphibians such as the newt and axolotl. However, the dynamic interactions between the regenerating tissue, the surrounding stroma, and the host immune response, as it adapts to the actively proliferating tissue, remain ill-defined. The regenerating zone, through a sequence of distinct molecular events, adopts phenotypic plasticity and undergoes rigorous tissue remodeling that, in turn, evokes a significant inflammatory response. Complement is a primordial sentinel of the innate immune response that engages in multiple inflammatory cascades as it becomes activated during tissue injury and remodeling. In this respect, complement proteins have been implicated in tissue and organ regeneration in both urodeles and mammals. Distinct complement-triggered pathways have been shown to modulate critical responses that promote tissue reprogramming, pattern formation, and regeneration across phylogenesis. This article will discuss the mechanistic insights underlying the crosstalk of complement with cytokine and growth factor signaling pathways that drive tissue regeneration and will provide a unified conceptual framework for considering complement modulation as a novel target for regenerative therapeutics. PMID:23684626

Mastellos, Dimitrios C; Deangelis, Robert A; Lambris, John D

2013-02-01

284

Engineering physical microenvironment for stem cell based regenerative medicine.  

PubMed

Regenerative medicine has rapidly evolved over the past decade owing to its potential applications to improve human health. Targeted differentiations of stem cells promise to regenerate a variety of tissues and/or organs despite significant challenges. Recent studies have demonstrated the vital role of the physical microenvironment in regulating stem cell fate and improving differentiation efficiency. In this review, we summarize the main physical cues that are crucial for controlling stem cell differentiation. Recent advances in the technologies for the construction of physical microenvironment and their implications in controlling stem cell fate are also highlighted. PMID:24508818

Han, Yu Long; Wang, Shuqi; Zhang, Xiaohui; Li, Yuhui; Huang, Guoyou; Qi, Hao; Pingguan-Murphy, Belinda; Li, Yinghui; Lu, Tian Jian; Xu, Feng

2014-06-01

285

Long life Regenerative Fuel Cell technology development plan  

NASA Astrophysics Data System (ADS)

This paper summarizes a technology roadmap for completing advanced development of a Proton Exchange Membrane (PEM) Regenerative Fuel Cell (RFC) to meet long life (20,000 hrs at 50 percent duty cycle) mobile or portable power system applications on the surface of the moon and Mars. Development of two different sized RFC power system modules is included in this plan (3 and 7.5 kWe). A conservative approach was taken which includes the development of a Ground Engineering System, Qualification Unit, and Flight Unit. This paper includes a concept description, technology assessment, development issues, development tasks, and development schedule.

Littman, Franklin D.; Cataldo, Robert L.; McElroy, James F.; Stedman, Jay K.

286

Long life Regenerative Fuel Cell technology development plan  

NASA Technical Reports Server (NTRS)

This paper summarizes a technology roadmap for completing advanced development of a Proton Exchange Membrane (PEM) Regenerative Fuel Cell (RFC) to meet long life (20,000 hrs at 50 percent duty cycle) mobile or portable power system applications on the surface of the moon and Mars. Development of two different sized RFC power system modules is included in this plan (3 and 7.5 kWe). A conservative approach was taken which includes the development of a Ground Engineering System, Qualification Unit, and Flight Unit. This paper includes a concept description, technology assessment, development issues, development tasks, and development schedule.

Littman, Franklin D.; Cataldo, Robert L.; Mcelroy, James F.; Stedman, Jay K.

1992-01-01

287

Regeneratively cooled rocket engine for space storable propellants  

NASA Technical Reports Server (NTRS)

Analysis, design, fabrication, and test efforts were performed for the existing OF2/B2H6 regeneratively cooled lK (4448 N) thrust chamber to illustrate simultaneous B2H6 fuel and OF2 oxidizer cooling and to provide results for a gaseous propellant condition injected into the combustion chamber. Data derived from performance, thermal and flow measurements confirmed predictions derived from previous test work and from concurrent analytical study. Development data derived from the experimental study were indicated to be sufficient to develop a preflight thrust chamber demonstrator prototype for future space mission objectives.

Wagner, W. R.

1973-01-01

288

Laser frequency stabilization using regenerative spectral hole burning  

NASA Astrophysics Data System (ADS)

We demonstrate laser frequency stabilization using a continuously regenerated transient spectral hole in an inhomogeneously broadened resonance of a solid. Regenerative transient holes provide extreme stabilization for time scales appropriate for spectroscopy, signal processing, ranging, and interferometry. Stabilization to 20 Hz on a 10-ms time scale using spectral holes at 793 nm in Tm3+:Y3Al5O12 gives substantial improvement in the reliability of stimulated photon echoes in the same material and enables the observation of a third population storage mechanism for hole burning in Tm3+:Y3Al5O12.

Strickland, N. M.; Sellin, P. B.; Sun, Y.; Carlsten, J. L.; Cone, R. L.

2000-07-01

289

Skin Wound Healing and Scarring: Fetal Wounds and Regenerative Restitution  

PubMed Central

The adverse physiological and psychological effects of scars formation after healing of wounds are broad and a major medical problem for patients. In utero, fetal wounds heal in a regenerative manner, though the mechanisms are unknown. Differences in fetal scarless regeneration and adult repair can provide key insight into reduction of scarring therapy. Understanding the cellular and extracellular matrix alterations in excessive adult scarring in comparison to fetal scarless healing may have important implications. Herein, we propose that matrix can be controlled via cellular therapy to resemble a fetal-like matrix that will result in reduced scarring. PMID:24203921

Yates, Cecelia C.; Hebda, Patricia; Wells, Alan

2014-01-01

290

Aquaculture in bio-regenerative life support systems (BLSS): Considerations  

NASA Astrophysics Data System (ADS)

A significant amount of research has been invested into understanding the effects of including fish culture in bio-regenerative life support systems (BLSS) for long duration space habitation. While the benefits of fish culture as a sub-process for waste treatment and food production continue to be identified, other pressing issues arise that affect the overall equivalent system mass associated with fish culture in a BLSS. This paper is meant to provide insight into several issues affecting fish culture in a BLSS that will require attention in the future if fish meant for consumption are to be cultured in a BLSS.

Gonzales, John M.

2009-04-01

291

A plurality voting method for acquisition of regenerative ranging measurements  

NASA Astrophysics Data System (ADS)

Sequential tone ranging and regenerative ranging may both be considered to consist of two parts: acquisition of the ranging clock phase, from which the range accuracy is derived, and a resolution of the range ambiguity that remains when only the clock period is considered. With sequential tone ranging, the ambiguity is resolved by dividing the frequency of the ranging tone in steps until the remaining ambiguity is resolved by knowledge of the spacecraft position. With regenerative ranging, the ambiguity is resolved by a determination of the phase of a long ranging code. This code phase is determined by both the spacecraft, which then regenerates the code, and by the ground station. It is possible to have sufficient signal-to-noise ratio to provide good range measurement accuracy with regenerative ranging and yet have insufficient signal-to-noise ratio (SNR) to acquire the proper range code phase at the ground station for each individual range measurement. A set of range measurements may be processed together to determine the proper range ambiguity resolution even when none of the individual measurements is reliable. An approach of processing together a set of measurements has been developed and applied to data from the New Horizons mission while the spacecraft was in excess of 22 Astronautical Units from Earth. The value of T*Pr/No was less than 30 dB, making normal processing of the data unreliable. Consistent and correct results have been demonstrated even when the initial range phase values were scattered over the entire possible range of values. This paper will present the method of processing together a set of range measurements and show the application of this method to New Horizons data. The predicted probability of success as a function of the number of available points and the signal-to-noise ratio of the individual points is presented. The SNR required for correct acquisition of the ranging code can be reduced by 15 dB relative to the requirement for indi- idual range measurements when 120 range measurements are processed together. This approach expands the conditions over which regenerative ranging will be successful in deep space missions.

Jensen, J. R.

292

High Pressure Regenerative Turbine Engine: 21st Century Propulsion  

NASA Technical Reports Server (NTRS)

A novel semi-closed cycle gas turbine engine was demonstrated and was found to meet the program goals. The proof-of-principle test of the High Pressure Regenerative Turbine Engine produced data that agreed well with models, enabling more confidence in designing future prototypes based on this concept. Emission levels were significantly reduced as predicted as a natural attribute of this power cycle. Engine testing over a portion of the operating range allowed verification of predicted power increases compared to the baseline.

Lear, W. E.; Laganelli, A. L.; Senick, Paul (Technical Monitor)

2001-01-01

293

Maspin expression, subcellular localization and clinicopathological correlation in endometrial hyperplasia and endometrial adenocarcinoma.  

PubMed

Maspin expression in endometrial hyperplasia and endometrial endometrioid adenocarcinomas was assessed and its correlation with p53 and Ki67 expressions and clinical outcome, as well as its potential to distinguish typical from atypical endometrial hyperplasia, were assessed in this study. Histological sections from 114 cases of endometrial endometrioid adenocarcinoma, 75 cases of endometrial hyperplasia (typical and atypical), and 23 normal endometrial tissue samples were examined. The most representative hematoxylin-eosin slides were selected and 2-3 micron-thick sections were cut for immunohistochemical staining with maspin, p53, and Ki67 antibodies. While there was no maspin expression in normal endometrial cells, it was present in 14.5% of the patients with endometrial hyperplasia without atypia. Staining for maspin was positive in atypical hyperplasia and endometrial adenocarcinoma in, respectively, 45% and 49.1% of the cases studied. No statistically significant correlations were found between maspin and Ki-67 antibodies or p53 expression. Our findings showed that maspin expression, which generally correlates with a less aggressive behavior, is significantly higher in atypical hyperplasia and in endometrial endometrioid adenocarcinoma. Maspin positivity in endometrial hyperplasia could be used to identify pseudo-atypical hyperplasia and could be considered a potentially useful prognostic parameter in those cases in which adenocarcinomas are well differentiated. PMID:24346847

Blandamura, Stella; Alessandrini, Lara; Saccardi, Carlo; Giacomelli, Luciano; Fabris, Alberta; Borghero, Angela; Litta, Pietro

2014-06-01

294

Effect of an integral suspension of Lepidium latifolium on prostate hyperplasia in rats  

Microsoft Academic Search

This paper studies the effect of an integral suspension of Lepidium latifolium on experimental induced prostate hyperplasia, in rats. Oral treatment with 0.86 mg kg?1 day?1 for 6 months, significantly reduced prostate size and volume in castrated rats where the hyperplasia were induced by steroid treatment.

S. Mart??nez Caballero; C. Carricajo Fernández; R. Pérez-Fernández

2004-01-01

295

Effect of an integral suspension of Lepidium latifolium on prostate hyperplasia in rats.  

PubMed

This paper studies the effect of an integral suspension of Lepidium latifolium on experimental induced prostate hyperplasia, in rats. Oral treatment with 0.86 mg kg(-1) day(-1) for 6 months, significantly reduced prostate size and volume in castrated rats where the hyperplasia were induced by steroid treatment. PMID:15030923

Martínez Caballero, S; Carricajo Fernández, C; Pérez-Fernández, R

2004-03-01

296

Atypical endometrial hyperplasia shares genomic abnormalities with endometrioid carcinoma by comparative genomic hybridization  

Microsoft Academic Search

Endometrial hyperplasia is a common disorder that is now observed with increasing frequency in women treated with hormonal replacement therapy or with tamoxifen. This study was undertaken to determine whether genomic features of various forms of endometrial hyperplasias would allow their classification as a benign, premalignant, or malignant abnormality. Comparative genomic hybridization (CGH) was performed on endometrial glands microdissected by

Huseyin Baloglu; Linda A Cannizzaro; Joan Jones; Leopold G Koss

2001-01-01

297

Surgical management of mandibular condylar hyperplasia type 1  

PubMed Central

This study compared outcomes of two surgical methods for patients diagnosed with active condylar hyperplasia type 1. Group 1 (n = 12) was treated with orthognathic surgery only, while group 2 (n = 42) was treated with high condylectomies, articular disc repositioning, and orthognathic surgery. There was no statistically significant difference between the two groups for maximum incisal opening, lateral excursions, and subjective jaw function before surgery. Group 2 showed more active presurgical mandibular growth (P < 0.05). At long-term follow up, no differences were found in lateral excursions and subjective jaw function. Group 2 showed a greater increase in maximum incisal opening (P < 0.01) and stability (P < 0.05) at long-term follow-up. All of the patients in group 1 grew back into skeletal and occlusal Class III relationships requiring secondary intervention, whereas all patients in group 2 remained stable in a Class I skeletal and occlusal relationship. Thus, patients with active condylar hyperplasia treated with high condylectomy, articular disc repositioning, and orthognathic surgery had stable, predictable outcomes compared with those treated with orthognathic surgery only. The high condylectomy effectively arrests disproportionate mandibular growth while maintaining normal jaw function. PMID:19865502

Morales-Ryan, Carlos A.; Garcia-Morales, Patricia; Perez, Daniel

2009-01-01

298

Radiation inhibition of intimal hyperplasia after arterial injury  

SciTech Connect

To demonstrate the effect of {gamma} radiation on proliferating smooth muscle cells in vivo, a standardized bilateral carotid balloon catheter arterial injury was produced in 45 rats and doses from 0-20 Gy were delivered to the right carotid artery at 24 h after injury. At 20 days after injury, cross-sectional area of intima was determined from axial histological sections. Compared to contralateral, nonirradiated balloon-injured arteries, radiation produced a significant dose-dependent reduction in intimal cross-sectional area, with a 50% decrease at 5-7.5 Gy. To determine the effect of timing of irradiation on intimal hyperplasia, 30 rats with bilateral carotid injury received unilateral cervical irradiation at doses of 1,5 or 10 Gy administered at either 1,3 or 5 days after injury. The radiation dose, timing of irradiation and an interaction between timing and dose were significantly associated with reduction in neointimal cross-sectional area. To determine the effects of radiation on intimal hyperplasia at later intervals, rats irradiated with 15 or 20 Gy were euthanized at 3 months after injury. A significant persistent reduction in intimal cross-sectional area for irradiated arteries at 3 months was associated with minimal apparent radiation effects upon adjacent tissue. These data suggest that external {gamma} irradiation at the single doses used effectively inhibits smooth muscle proliferation and intimal hyperlasia in the rat balloon catheter injury model in a time- and dose-dependent manner. 54 refs., 6 figs., 1 tab.

Mayberg, M.R.; Luo, Z.; London, S.; Gajdusek, C.; Rasey, J.S. [Univ. of Washington, Seattle, WA (United States)

1995-05-01

299

Altered catecholamine receptor affinity in rabbit aortic intimal hyperplasia  

SciTech Connect

Intimal thickening is a universal response to endothelial denudation and is also thought to be a precursor of atherosclerosis. The authors have demonstrated selective supersensitivity in arterial intimal hyperplasia to norepinephrine and they now report a possible mechanism for this. Binding studies in rabbit aorta with the selective alpha 1-adrenergic radioligand 125I-HEAT demonstrated that there was no change in receptor density (20 {plus minus} 4 fmole/10(6) cells) in intact vascular smooth muscle cells at either 5 or 14 days after denudation. However, competition studies showed a 2.6-fold increase in alpha 1-adrenergic receptor affinity for norepinephrine in intimal hyperplastic tissue (P less than 0.05). This increased affinity for norepinephrine was associated with a greater increase in 32P-labeled phosphatidylinositol (148% intimal thickening versus 76% control) and phosphatidic acid (151% intimal thickening versus 56% control) following norepinephrine stimulation of free floating rings of intimal hyperplastic aorta. These data suggest that the catecholamine supersensitivity in rabbit aortic intimal hyperplasia is receptor mediated and may be linked to the phosphatidylinositol cycle.

O'Malley, M.K.; Cotecchia, S.; Hagen, P.O. (Duke University Medical Center, Durham, NC (USA))

1991-08-01

300

Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice. A preliminary report  

EPA Science Inventory

Arsenic (+3 oxidation state) methyltransferase (As3mt) catalyzes reactions which convert inorganic arsenic to methylated metabolites. This study determined whether the As3mt null genotype in the mouse modifies cytotoxic and proliferative effects seen in urinary bladders of wild t...

301

Advances and New Frontiers in the Pathophysiology of Venous Neointimal Hyperplasia and Dialysis Access Stenosis  

PubMed Central

Hemodialysis vascular access dysfunction is a major cause of morbidity and mortality in hemodialysis patients. The most common cause of this vascular access dysfunction is venous stenosis as a result of venous neointimal hyperplasia within the peri-anastomotic region (AV fistula) or at the graft-vein anastomosis (PTFE grafts). There have been few effective treatments to-date for venous neointimal hyperplasia in part because of the poor understanding of the pathogenesis of venous neointimal hyperplasia. Therefore, this article will (1) describe the pathology of hemodialysis access stenosis in AV fistulas and grafts, (2) review and describe both current and novel concepts in the pathogenesis of neointimal hyperplasia formation, (3) discuss current and future novel therapies for treating venous neointimal hyperplasia, and (4) suggest future research areas in the field of hemodialysis vascular access dysfunction. PMID:19695501

Lee, Timmy; Roy-Chaudhury, Prabir

2009-01-01

302

Regeneratively cooled rocket engine for space storable propellants  

NASA Technical Reports Server (NTRS)

Analyses and experimental studies were performed with the OF2 (F2/O2)/B2H6 propellant combination over a range in operating conditions to determine suitability for a space storable pressure fed engine configuration for an extended flight space vehicle configuration. The regenerative cooling mode selected for the thrust chamber was explored in detail with the use of both the fuel and oxidizer as coolants in an advanced milled channel construction thrust chamber design operating at 100 psia chamber pressure and a nominal mixture ratio of 3.0 with a 60:1 area ratio nozzle. Benefits of the simultaneous cooling as related to gaseous injection of both fuel and oxidizer propellants were defined. Heat transfer rates, performance and combustor stability were developed for impinging element triplet injectors in uncooled copper calorimeter hardware with flow, pressure and temperature instrumentation. Evaluation of the capabilities of the B2H6 and OF2 during analytical studies and numerous tests with flow through electrically heated blocks provided design criteria for subsequent regenerative chamber design and fabrication.

Wagner, W. R.; Waldman, B. J.

1973-01-01

303

Johnson Space Center's Regenerative Life Support Systems Test Bed  

NASA Astrophysics Data System (ADS)

The Regenerative Life Support Systems (RLSS) Test Bed at NASA's Johnson Space Center is an atmospherically closed, controlled environment facility for human testing of regenerative life support systems using higher plants in conjunction with physicochemical life support systems. The facility supports NASA's Advanced Life Support (ALS) Program. The facility is comprised of two large scale plant growth chambers, each with approximately 11 m^2 growing area. The root zone in each chamber is configurable for hydroponic or solid media plant culture systems. One of the two chambers, the Variable Pressure Growth Chamber (VPGC), is capable of operating at lower atmospheric pressures to evaluate a range of environments that may be used in a planetary surface habitat; the other chamber, the Ambient Pressure Growth Chamber (APGC) operates at ambient atmospheric pressure. The air lock of the VPGC is currently being outfitted for short duration (1 to 15 day) human habitation at ambient pressures. Testing with and without human subjects will focus on 1) integration of biological and physicochemical air and water revitalization systems; 2) effect of atmospheric pressure on system performance; 3) planetary resource utilization for ALS systems, in which solid substrates (simulated planetary soils or manufactured soils) are used in selected crop growth studies; 4) environmental microbiology and toxicology; 5) monitoring and control strategies; and 6) plant growth systems design. Included are descriptions of the overall design of the test facility, including discussions of the atmospheric conditioning, thermal control, lighting, and nutrient delivery systems.

Barta, D. J.; Henninger, D. L.

1996-01-01

304

Renal stem cell reprogramming: Prospects in regenerative medicine  

PubMed Central

Stem cell therapy is a promising future enterprise for renal replacement in patients with acute and chronic kidney disease, conditions which affect millions worldwide and currently require patients to undergo lifelong medical treatments through dialysis and/or organ transplant. Reprogramming differentiated renal cells harvested from the patient back into a pluripotent state would decrease the risk of tissue rejection and provide a virtually unlimited supply of cells for regenerative medicine treatments, making it an exciting area of current research in nephrology. Among the major hurdles that need to be overcome before stem cell therapy for the kidney can be applied in a clinical setting are ensuring the fidelity and relative safety of the reprogrammed cells, as well as achieving feasible efficiency in the reprogramming processes that are utilized. Further, improved knowledge about the genetic control of renal lineage development is vital to identifying predictable and efficient reprogramming approaches, such as the expression of key modulators or the regulation of gene activity through small molecule mimetics. Here, we discuss several recent advances in induced pluripotent stem cell technologies. We also explore strategies that have been successful in renal progenitor generation, and explore what these methods might mean for the development of cell-based regenerative therapies for kidney disease. PMID:25258667

Morales, Elvin E; Wingert, Rebecca A

2014-01-01

305

Renal stem cell reprogramming: Prospects in regenerative medicine.  

PubMed

Stem cell therapy is a promising future enterprise for renal replacement in patients with acute and chronic kidney disease, conditions which affect millions worldwide and currently require patients to undergo lifelong medical treatments through dialysis and/or organ transplant. Reprogramming differentiated renal cells harvested from the patient back into a pluripotent state would decrease the risk of tissue rejection and provide a virtually unlimited supply of cells for regenerative medicine treatments, making it an exciting area of current research in nephrology. Among the major hurdles that need to be overcome before stem cell therapy for the kidney can be applied in a clinical setting are ensuring the fidelity and relative safety of the reprogrammed cells, as well as achieving feasible efficiency in the reprogramming processes that are utilized. Further, improved knowledge about the genetic control of renal lineage development is vital to identifying predictable and efficient reprogramming approaches, such as the expression of key modulators or the regulation of gene activity through small molecule mimetics. Here, we discuss several recent advances in induced pluripotent stem cell technologies. We also explore strategies that have been successful in renal progenitor generation, and explore what these methods might mean for the development of cell-based regenerative therapies for kidney disease. PMID:25258667

Morales, Elvin E; Wingert, Rebecca A

2014-09-26

306

Macro and Microfluidic Flows for Skeletal Regenerative Medicine  

PubMed Central

Fluid flow has a great potential as a cell stimulatory tool for skeletal regenerative medicine, because fluid flow-induced bone cell mechanotransduction in vivo plays a critical role in maintaining healthy bone homeostasis. Applications of fluid flow for skeletal regenerative medicine are reviewed at macro and microscale. Macroflow in two dimensions (2D), in which flow velocity varies along the normal direction to the flow, has explored molecular mechanisms of bone forming cell mechanotransduction responsible for flow-regulated differentiation, mineralized matrix deposition, and stem cell osteogenesis. Though 2D flow set-ups are useful for mechanistic studies due to easiness in in situ and post-flow assays, engineering skeletal tissue constructs should involve three dimensional (3D) flows, e.g., flow through porous scaffolds. Skeletal tissue engineering using 3D flows has produced promising outcomes, but 3D flow conditions (e.g., shear stress vs. chemotransport) and scaffold characteristics should further be tailored. Ideally, data gained from 2D flows may be utilized to engineer improved 3D bone tissue constructs. Recent microfluidics approaches suggest a strong potential to mimic in vivo microscale interstitial flows in bone. Though there have been few microfluidics studies on bone cells, it was demonstrated that microfluidic platform can be used to conduct high throughput screening of bone cell mechanotransduction behavior under biomimicking flow conditions. PMID:24710552

Riehl, Brandon D.; Lim, Jung Yul

2012-01-01

307

Abnormal beam-profile behavior in the Nd:YAG ceramic regenerative amplifier  

NASA Astrophysics Data System (ADS)

The output beam profile of a Nd:YAG diode-pumped ceramic regenerative amplifier depends heavily on amplified spontaneous emission (ASE) and amplification competition. A careful pump geometry arrangement is required in a highgain regenerative amplifier to achieve the beam profile that corresponds to the TEM00 mode of the amplifier cavity.

Okishev, A. V.

2014-02-01

308

Conceptual design of a 10MW regenerative isobutane geothermal power plant  

Microsoft Academic Search

The regenerative binary cycle, as applied to the geothermal brines for the generation of power, is evaluated. To improve the thermal efficiency of the basic cycle, a regenerative heat exchanger is used to transfer the heat from the turbine exhaust to the compressed isobutane entering the main heat exchanger. This results in reducing the size of the condenser, cooling equipment,

A. K. Gupta; J. L. S. Chou

1976-01-01

309

Estimation of the untapped regenerative braking energy in urban electric transportation network  

Microsoft Academic Search

The paper presents an estimation of the reserves of untapped regenerative braking energy in the power supply network of urban electric transport. The estimation is made by a method based on probabilistic principles, transport timetable and measured power diagrams. The amount of unused regenerative energy is calculated for two substations in the electric transport network in Riga, with power measurement

Leonards Latkovskis; L. Grigans

2008-01-01

310

A Fuzzy Logic Based Regenerative Braking Regulation For a Fuel Cell Bus  

Microsoft Academic Search

For a fuel cell bus, it is significant to equip the regenerative break system to enhance the fuel economy. A two-input, one-output Mamdani's fuzzy inference system is introduced to the regenerative braking model. Taking the safety working conditions of the batteries, the driving dynamics and the occupant comfort into consideration, the method can not only recycle the bus braking energy

Jie Yao; Zaimin Zhong; Sun Zechang

2006-01-01

311

A neural network based SRM drive control strategy for regenerative braking in EV and HEV  

Microsoft Academic Search

The characteristics of the regenerative braking in EV and HEV are analyzed in this paper. A neural network based SRM drive control strategy is developed for satisfying the requirements of regenerative braking in EV and HEV when SRM is chosen as the power source of EV and HEV. The energy recovery efficiency of the proposed control strategy is also evaluated

Hongwei Gao; Yimin Gao; Mehrdad Ehsani

2001-01-01

312

Power Management Strategy with Regenerative Braking For Fuel Cell Hybrid Electric Vehicle  

Microsoft Academic Search

A novel power management strategy based on regenerative braking is proposed to make optimal power distribution between fuel cell system and batteries in order to improve the utility of braking energy and decrease the power loss for fuel cell electric vehicle. With the integrated regenerative braking strategy, the novel control algorithm takes the charging power loss from regenerated energy into

Yu Shuang; Zhang Junzhi; Wang Lifang

2009-01-01

313

ENSC 461 PROJECT: Development of a new hydraulic regenerative energy storage system  

E-print Network

1 ENSC 461 PROJECT: Development of a new hydraulic regenerative energy storage system Assigned batteries, among them is hydraulic regenerative system (HRS). Principle of operation: electricity is used's powertrain during the brake period and the regenerated energy is transferred back to the powertrain

Bahrami, Majid

314

Regenerative-braking sliding mode control of electric vehicle based on neural network identification  

Microsoft Academic Search

Aiming at the main problems of electric vehicle (EV): short driving range, short life of batteries, and variation of model parameters, based on constructing the main circuit diagram of the EVpsilas control system, the mathematical model of regenerative-braking process was established, and a novel regenerative-braking controller was designed, which combined neural network (NN) with traditional sliding mode controller (SMC). The

Jianbo Cao; Binggang Cao; Peng Xu; Zhifeng Bai

2008-01-01

315

ENERGY HARVESTING, RIDE COMFORT, AND ROAD HANDLING OF REGENERATIVE VEHICLE SUSPENSIONS  

E-print Network

1 ENERGY HARVESTING, RIDE COMFORT, AND ROAD HANDLING OF REGENERATIVE VEHICLE SUSPENSIONS Lei Zuo vehicles travel on the road, they are always subjected to the excitation from road irregularities, braking]. However, it requires significant amount energy, which limits its wide implementations. Hence, regenerative

Zuo, Lei

316

Study on the performance and control of SR machine for vehicle regenerative braking  

Microsoft Academic Search

A regenerative braking system with simple structure, high efficiency, good performance and easy control is crucial for electric vehicle (EV), hybrid electric vehicle (HEV) and fuel cell vehicle (FCV). SR machine is one of the promising candidates. In this paper, the current and torque performance of a SR machine for application to vehicle regenerative braking has been studied. The relationship

Xiaoling Yuan; Yimin Gao; M. Ehsani

2008-01-01

317

PERFORMANCE AND ANALYSIS OF CHOPPER FED D.C. SEPARATELY EXCITED MOTOR UNDER REGENERATIVE BRAKING  

Microsoft Academic Search

A method is presented here to analyse the performance of a separately excited d.c. motor under regenerative braking mode and provides a technique to select the necessary inductance to reduce the ripple in the armature current as well as to eliminate the discontinuous conduction of the armature current and to optimize the regenerative power. The effect of armature reaction and

H. SATPATHI; G. K. DUBEY; L. P. SINGH

1980-01-01

318

Analysis of low temperature solar thermal electric generation using regenerative Organic Rankine Cycle  

Microsoft Academic Search

The innovative configuration of low temperature solar thermal electric generation with regenerative Organic Rankine Cycle (ORC) is designed, mainly consisting of small concentration ratio compound parabolic concentrators (CPC) and the regenerative ORC. Advantages of the innovative configuration such as effectively reducing heat transfer irreversibility and permitting the use of thermal storage with phase change materials (PCMs) are outlined. The numerical

Gang Pei; Jing Li; Jie Ji

2010-01-01

319

J Hepatol. Author manuscript The beta-catenin pathway is activated in focal nodular hyperplasia but not  

E-print Network

hyperplasia but not in cirrhotic FNH-like nodules Rebouissou Sandra 1 2 , Couchy Gabrielle 1 2 , Libbrecht@cephb.fr> Abstract Background & Aims Focal nodular hyperplasias (FNHs) are benign liver lesions considered-Regulation ; genetics ; Extracellular Matrix ; genetics ; metabolism ; Female ; Focal Nodular Hyperplasia ; metabolism

Paris-Sud XI, Université de

320

The -Catenin Pathway is Activated in Focal Nodular Hyperplasia but not in Cirrhotic FNH-like Nodules  

E-print Network

ForReview Only The -Catenin Pathway is Activated in Focal Nodular Hyperplasia but not in Cirrhotic, Tania; University of Leuven Bioulac-Sage, Paulette; Inserm U889 Key Words: Focal nodular hyperplasia: Focal nodular hyperplasias (FNHs) are benign liver lesions considered to be a hyperplastic response

321

Development of a co-operative control algorithm during regenerative braking for a fuel cell electric vehicle  

Microsoft Academic Search

In this study, a regenerative braking control algorithm was developed for the fuel cell electric vehicle (FCEV) equipped with the front electronic wedge brake (EWB). A regenerative braking control algorithm was proposed for the regenerative braking and friction braking for the front wheels, and for the friction braking for the rear wheels; and a powertrain model of an FCEV composed

Jiweon Ko; Jungwook Kim; Gaeun Lee; Sunggon Byun; Dongyoon Hyun; Hyunsoo Kim

2011-01-01

322

In regenerative braking system of a HEV, the power electronics are controlled such that the traction motor  

E-print Network

ABSTRACT In regenerative braking system of a HEV, the power electronics are controlled and emission [1]. An important system of hybrid electric vehicles is regenerative braking system (RBS). The RBS braking systems are major concerns. In the area of regenerative braking in HEVs, some studies have been

Vaziri, Ashkan

323

Nanotechnology-based approaches for regenerative medicine and biosensing  

NASA Astrophysics Data System (ADS)

The recent emergence of nanotechnology has set high expectations in many fields of science, especially in biology and medicine. Nanotechnology-based approaches are expected to solve key questions in the emerging field of regenerative medicine. Regenerative medicine essentially deals with regeneration of cells, ultimately leading to the formation of tissues and organs. For this purpose, stem cells, embryonic stem cells or adult stem cells, are thought to be ideal resources. However, many challenges need to be addressed before the full therapeutic potential of stem cells can be harnessed. Controlling the differentiation of stem cells into cells of a specific lineage is extremely vital and challenging. Addressing this challenge, in this work, novel nanotechnology-based approaches for controlling the differentiation of neural stem cells (NSCs) into neurons has been presented. Regeneration of damaged neurons, due to traumatic injuries or degenerative diseases, is extremely challenging. For this purpose, NSCs can be used as resources that can differentiate into neurons, thus having great potential in solving needs of many patients suffering from such conditions. For controlling the differentiation of stem cells, soluble cues (comprising of small molecules and biomolecules) and insoluble cues (cell-cell interactions and cell-microenvironment interactions) play a very important role. The delivery of soluble cues, such as genetic material, into stem cells is extremely challenging. The initial part of this work presents the use of nanomaterials for efficiently delivering soluble cues such as small molecules and small interfering RNA (siRNA) into NSCs for controlling their differentiation into neurons. However, for regenerative purposes, it is preferred that least amounts of the delivery vehicle be used. Thus, the following part of the thesis presents the development and applications of nanotechnology-based approaches for enhancing the differentiation of NSCs into neurons using insoluble cues. The cellular microenvironment, consisting for the extracellular matrix (ECM) was modified by the use of nanostructures, to deliver siRNA into NSCs to enhance neuronal differentiation. Nanotopography-mediated reverse uptake of only the siRNA molecules from the ECM was achieved by the NSCs. NSC differentiation was also controlled by the use of protein micropatterns, wherein the pattern geometry and size defined the fate of the NSCs. Lastly, graphene, in combination with nanoparticles was used as component of the ECM to not only enhance the differentiation of NSCs into neurons, but also align the axons of the differentiated NSCs, having significant implications for its use in regenerating injured spinal cords. The final portion of the thesis presents the applications of nanotechnology for developing highly sensitive and selective biosensors, for detecting biomarkers implicated in various diseases such as cancer and acute pancreatitis.

Solanki, Aniruddh P.

324

T-cell-predominant lymphoid hyperplasia in a tattoo*  

PubMed Central

Cutaneous lymphoid hyperplasia (CLH) can be idiopathic or secondary to external stimuli, and is considered rare in tattoos. The infiltrate can be predominantly of B or T-cells, the latter being seldom reported in tattoos. We present a case of a predominantly T CLH, secondary to the black pigment of tattooing in a 35-year-old patient, with a dense infiltrate of small, medium and scarce large T-cells. Analysis of the rearrangement of T-cells receptor revealed a polyclonal proliferation. Since the infiltrate of CLH can simulate a T lymphoma, it is important to show that lesions from tattoos can have a predominance of T-cells. PMID:25387518

Souza, Erica Sales; Rocha, Bruno de Oliveira; Batista, Everton da Silva; de Oliveira, Rodrigo Ferreira; Farre, Lourdes; Bittencourt, Achilea Lisboa

2014-01-01

325

[New developments in the diagnosis of benign prostatic hyperplasia].  

PubMed

The first phase in the diagnosis of patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia is to exclude another disease. This initial evaluation consist of anamnesis, including the quantification of symptoms according to the International Prostatic Symptom Score, physical examination--with digital rectal examination playing a central role, urinalysis, and renal function assessment; the prostate-specific antigen may suggest prostate cancer or may predict the volume of the prostate and the natural evolution of the disease. If, after the initial evaluation, the diagnosis is still uncertain, further investigations are necessary: imagistic exploration of the urinary tract, urodynamic tests or urethro-cystoscopy. The authors review current knowledge. PMID:19292085

Vaida, M; Novac, B; Gheorghiu, V; Novac, C

2006-01-01

326

Angiolymphoid hyperplasia with eosinophilia: a clinicopathologic study of 9 cases.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disease characterized by single or multiple angiomatous lesions typically located on the scalp and the face. We present a retrospective analysis of 9 cases of ALHE. The lesions appeared largely as multiple grouped papules or, in some cases, subcutaneous nodules, located mainly on the scalp, particularly around the ear. We also observed lesions in atypical locations, such as areas of the head other than the scalp, and the shoulder, neck, and forearm. At these sites the lesions had an atypical clinical appearance that made diagnosis difficult; this should be borne in mind in patients with single, well-delimited lesions with a vascular appearance and superficial ulceration or crusting. Surgery was the most common treatment in our series, and even though ALHE is considered a benign condition, recurrence was common. PMID:23845664

Guinovart, R M; Bassas-Vila, J; Morell, L; Ferrándiz, C

2014-03-01

327

Mandible condylar hyperplasia: a review of diagnosis and treatment protocol  

PubMed Central

Condylar hyperplasia (CH) is a bone disease characterized by the increased development of one mandibular condyle. It regularly presents as an active growth with facial asymmetry generally without pain. Statistically it affects more women in adolescence, although it does not discriminate by age or gender. Its best-known consequence is asymmetric facial deformity (AFD), which combined with alteration of the dental occlusion with unilateral crossbite or open bite. It is not known when CH begins and how long it lasts; diagnostic examinations are described and are efficient in some research about diagnosis. Protocol treatment is not well studie and depends on the criteria described in this paper. The aim of this research is to provide up-to-date information about the diagnosis of this disease and to analyze the treatment protocol, visualizing the CH and AFD presented. PMID:24179565

Olate, Sergio; Netto, Henrique Duque; Rodriguez-Chessa, Jaime; Alister, Juan Pablo; de Albergaria-Barbosa, Jose; de Moraes, Marcio

2013-01-01

328

Nerve hyperplasia: a unique feature of ketamine cystitis  

PubMed Central

Background There is an emerging association between ketamine abuse and the development of urological symptoms including dysuria, frequency and urgency, which have a neurological component. In addition, extreme cases are associated with severe unresolving bladder pain in conjunction with a thickened, contracted bladder and an ulcerated/absent urothelium. Here we report on unusual neuropathological features seen by immunohistology in ketamine cystitis. Results In all cases, the lamina propria was replete with fine neurofilament protein (NFP+) nerve fibres and in most patients (20/21), there was prominent peripheral nerve fascicle hyperplasia that showed particular resemblance to Morton’s neuroma. The nerve fascicles, which were positive for NFP, S100 and the p75 low-affinity nerve growth factor receptor (NGFR), were generally associated with a well-developed and in places, prominent, epithelial membrane antigen+/NGFR+ perineurium. This peripheral nerve fascicle hyperplasia is likely to account for the extreme pain experienced by ketamine cystitis patients. Urothelial damage was a notable feature of all ketamine cystitis specimens and where urothelium remained, increased NGFR expression was observed, with expansion from a basal-restricted normal pattern of expression into the suprabasal urothelium. Conclusions The histological findings were distinguishing features of ketamine cystitis and were not present in other painful bladder conditions. Ketamine cystitis afflicts predominantly young patients, with unknown long-term consequences, and requires a strategy to control severe bladder pain in order to remove a dependency on the causative agent. Our study indicates that the development of pain in ketamine cystitis is mediated through a specific neurogenic mechanism that may also implicate the urothelium. PMID:24252413

2013-01-01

329

Sodium Ferulate Inhibits Neointimal Hyperplasia in Rat Balloon Injury Model  

PubMed Central

Background/Aim Neointimal formation after vessel injury is a complex process involving multiple cellular and molecular processes. Inhibition of intimal hyperplasia plays an important role in preventing proliferative vascular diseases, such as restenosis. In this study, we intended to identify whether sodium ferulate could inhibit neointimal formation and further explore potential mechanisms involved. Methods Cultured vascular smooth muscle cells (VSMCs) isolated from rat thoracic aorta were pre-treated with 200 µmol/L sodium ferulate for 1 hour and then stimulated with 1 µmol/L angiotensin II (Ang II) for 1 hour or 10% serum for 48 hours. Male Sprague-Dawley rats subjected to balloon catheter insertion were administrated with 200 mg/kg sodium ferulate (or saline) for 7 days before sacrificed. Results In presence of sodium ferulate, VSMCs exhibited decreased proliferation and migration, suppressed intracellular reactive oxidative species production and NADPH oxidase activity, increased SOD activation and down-regulated p38 phosphorylation compared to Ang II-stimulated alone. Meanwhile, VSMCs treated with sodium ferulate showed significantly increased protein expression of smooth muscle ?-actin and smooth muscle myosin heavy chain protein. The components of Notch pathway, including nuclear Notch-1 protein, Jagged-1, Hey-1 and Hey-2 mRNA, as well as total ?-catenin protein and Cyclin D1 mRNA of Wnt signaling, were all significantly decreased by sodium ferulate in cells under serum stimulation. The levels of serum 8-iso-PGF2? and arterial collagen formation in vessel wall were decreased, while the expression of contractile markers was increased in sodium ferulate treated rats. A decline of neointimal area, as well as lower ratio of intimal to medial area was observed in sodium ferulate group. Conclusion Sodium ferulate attenuated neointimal hyperplasia through suppressing oxidative stress and phenotypic switching of VSMCs. PMID:24489938

Chen, Jing; Xu, Changwu; Ding, Jiawang; Yang, Jun; Guo, Qing; Hu, Qi; Jiang, Hong

2014-01-01

330

Tissue engineering and regenerative repair in wound healing.  

PubMed

Wound healing is a highly evolved defense mechanism against infection and further injury. It is a complex process involving multiple cell types and biological pathways. Mammalian adult cutaneous wound healing is mediated by a fibroproliferative response leading to scar formation. In contrast, early to mid-gestational fetal cutaneous wound healing is more akin to regeneration and occurs without scar formation. This early observation has led to extensive research seeking to unlock the mechanism underlying fetal scarless regenerative repair. Building upon recent advances in biomaterials and stem cell applications, tissue engineering approaches are working towards a recapitulation of this phenomenon. In this review, we describe the elements that distinguish fetal scarless and adult scarring wound healing, and discuss current trends in tissue engineering aimed at achieving scarless tissue regeneration. PMID:24788648

Hu, Michael S; Maan, Zeshaan N; Wu, Jen-Chieh; Rennert, Robert C; Hong, Wan Xing; Lai, Tiffany S; Cheung, Alexander T M; Walmsley, Graham G; Chung, Michael T; McArdle, Adrian; Longaker, Michael T; Lorenz, H Peter

2014-07-01

331

Solar powered water desalination system with a regenerative fixture  

SciTech Connect

A low pressure, low temperature, solar powered evaporating condensation system to provide relatively large scale conversion of brackish and seawater to fresh water, utilizes a solar radiation frequency selective material covered evaporation chamber, a throat connected elevated condenser containing energy transferring devices for vapor volume reduction to form a condensate which flows through a water-locked barometric leg to maintain the system at the sub-atmospheric pressure. The system is regenerative and includes means whereby the energy removed from the vapor during condensation is returned to the evaporating chamber and is again utilized in the cycle. Egress valves and locks are provided to maintain balanced flow of raw water, condensate and ejection of residuals. Suitable elevation of the condenser above the evaporator would provide for power generation.

Mckeen, J.E.

1980-11-25

332

Stem cells as tools in regenerative therapy for retinal degeneration  

PubMed Central

Objectives Regenerative medicine intends to provide therapies for severe injuries or chronic diseases where endogenous repair does not sufficiently restore the tissue. Pluripotent stem cells (SC), with their capacity to give rise to specialized cells, are the most promising candidates for clinical application. Despite encouraging results, a combination with up-to-date tissue engineering might be critical for ultimate success. Design The focus is on the use of SC for regeneration of retinal degenerations. Cell populations include embryonic, neural, and bone marrow-derived SC and engineered grafts will also be described. Results Experimental approaches have successfully replaced damaged photoreceptors and retinal pigment epithelium using endogenous and exogenous SC. Conclusions SC have the potential to significantly impact retinal regeneration. A combination with bioengineering may bear even greater promise. However, ethical and scientific issues have yet to be solved. PMID:19365041

Enzmann, Volker; Yolcu, Esma; Kaplan, Henry J.; Ildstad, Suzanne T.

2011-01-01

333

Regenerative Life Support Systems Test Bed performance - Lettuce crop characterization  

NASA Technical Reports Server (NTRS)

System performance in terms of human life support requirements was evaluated for two crops of lettuce (Lactuca sative cv. Waldmann's Green) grown in the Regenerative Life Support Systems Test Bed. Each crop, grown in separate pots under identical environmental and cultural conditions, was irrigated with half-strength Hoagland's nutrient solution, with the frequency of irrigation being increased as the crop aged over the 30-day crop tests. Averaging over both crop tests, the test bed met the requirements of 2.1 person-days of oxygen production, 2.4 person-days of CO2 removal, and 129 person-days of potential potable water production. Gains in the mass of water and O2 produced and CO2 removed could be achieved by optimizing environmental conditions to increase plant growth rate and by optimizing cultural management methods.

Barta, Daniel J.; Edeen, Marybeth A.; Eckhardt, Bradley D.

1992-01-01

334

Simple Signaling Molecules for Inductive Bone Regenerative Engineering  

PubMed Central

With greater than 500,000 orthopaedic procedures performed in the United States each year requiring a bone graft, the development of novel graft materials is necessary. We report that some porous polymer/ceramic composite scaffolds possess intrinsic osteoinductivity as shown through their capacity to induce in vivo host osteoid mineralization and in vitro stem cell osteogenesis making them attractive synthetic bone graft substitutes. It was discovered that certain low crystallinity ceramics partially dissociate into simple signaling molecules (i.e., calcium and phosphate ions) that induce stem cells to endogenously produce their own osteoinductive proteins. Review of the literature has uncovered a variety of simple signaling molecules (i.e., gases, ions, and redox reagents) capable of inducing other desirable stem cell differentiation through endogenous growth factor production. Inductive simple signaling molecules, which we have termed inducerons, represent a paradigm shift in the field of regenerative engineering where they can be utilized in place of recombinant protein growth factors. PMID:25019622

Nelson, Stephen J.; Deng, Meng; Sethuraman, Swaminathan; Doty, Stephen B.; Lo, Kevin W. H.; Khan, Yusuf M.; Laurencin, Cato T.

2014-01-01

335

Regenerative braking device with rotationally mounted energy storage means  

DOEpatents

A regenerative braking device for an automotive vehicle includes an energy storage assembly (12) having a plurality of rubber rollers (26, 28) mounted for rotation between an input shaft (30) and an output shaft (32), clutches (50, 56) and brakes (52, 58) associated with each shaft, and a continuously variable transmission (22) connectable to a vehicle drivetrain and to the input and output shafts by the respective clutches. In a second embodiment the clutches and brakes are dispensed with and the variable ratio transmission is connected directly across the input and output shafts. In both embodiments the rubber rollers are torsionally stressed to accumulate energy from the vehicle when the input shaft rotates faster or relative to the output shaft and are torsionally relaxed to deliver energy to the vehicle when the output shaft rotates faster or relative to the input shaft.

Hoppie, Lyle O. (Birmingham, MI)

1982-03-16

336

Regenerative flywheel energy storage system. Volume 1: Executive summary  

NASA Astrophysics Data System (ADS)

The development, fabrication, and test of a regenerative flywheel energy storage and recovery system for a battery/flywheel electric vehicle of the 3000 pound class are described. The vehicle propulsion system was simulated on a digital computer in order to determine the optimum system operating strategies and to establish a calculated range improvement over a nonregenerative, all electric vehicle. Fabrication of the inductor motor, the flywheel, the power conditioner, and the system control are described. Test results of the system operating over the SAE J227a Schedule D driving cycle are given and are compared to the calculated value. The flywheel energy storage system consists of a solid rotor, synchronous, inductor type, flywheel drive machine electrically coupled to a dc battery electric propulsion system through a load commutated inverter. The motor/alternator unit is coupled mechanically to a small steel flywheel which provides a portion of the vehicle's accelerating energy and regenerates the vehicle's braking energy.

1980-06-01

337

Alkaline regenerative fuel cell systems for energy storage  

NASA Technical Reports Server (NTRS)

A description is presented of the results of a preliminary design study of a regenerative fuel cell energy storage system for application to future low-earth orbit space missions. The high energy density storage system is based on state-of-the-art alkaline electrolyte cell technology and incorporates dedicated fuel cell and electrolysis cell modules. In addition to providing energy storage, the system can provide hydrogen and oxygen for attitude control of the satellite and for life support. During the daylight portion of the orbit the electrolysis module uses power provided by the solar array to generate H2 and O2 from the product water produced by the fuel cell module. The fuel cell module supplies electrical power during the dark period of the orbit.

Schubert, F. H.; Reid, M. A.; Martin, R. E.

1981-01-01

338

Microbiological characterization of a regenerative life support system  

NASA Astrophysics Data System (ADS)

A Variable Pressure Plant Growth Chamber (VPGC), at the Johnson Space Center's (JSC) ground-based Regenerative Life Support Systems (RLSS) test bed, was used to produce crops of soil-grown lettuce. The crops and chamber were analyzed for microbiological diversity during lettuce growth and after harvest. Bacterial counts for the rhizosphere, spent nutrient medium, heat exchanger condensate, and atmosphere were approximately 1011 Colony Forming Units (CFU) g-1, 105 CFU ml-1, 105 CFU ml-1, and 600 CFU m-3, respectively. Pseudomonas was the predominant bacterial genus. Numbers of fungi were about 105 CFU g-1 in the rhizosphere, 4-200 CFU ml-1 in thespent nutrient medium, 110 CFU ml-1 in the heat exchanger condensate, and 3 CFU m-3 in the atmosphere. Fusarium and Trichoderma were the predominant fungal genera.

Koenig, D. W.; Bruce, R. J.; Mishra, S. K.; Barta, D. J.; Pierson, D. L.

1994-11-01

339

Treatment Options: Biological Basis of Regenerative Endodontic Procedures  

PubMed Central

Dental trauma occurs frequently in children and often can lead to pulpal necrosis. The occurrence of pulpal necrosis in the permanent but immature tooth represents a challenging clinical situation since the thin and often short roots increase the risk of subsequent fracture. Current approaches for treating the traumatized immature tooth with pulpal necrosis do not reliably achieve the desired clinical outcomes, consisting of healing of apical periodontitis, promotion of continued root development and restoration of the functional competence of pulpal tissue. An optimal approach for treating the immature permanent tooth with a necrotic pulp would be to regenerate functional pulpal tissue. This review summarizes the current literature supporting a biological rationale for considering regenerative endodontic treatment procedures in treating the immature permanent tooth with pulp necrosis. PMID:23439043

Hargreaves, Kenneth M.; Diogenes, Anibal; Teixeira, Fabricio B.

2013-01-01

340

Biomaterials in regenerative medicine: engineering to recapitulate the natural.  

PubMed

The functional significance of the extracellular matrix (ECM) has generally been defined in terms of the provision of a structural support for cell adhesion and the establishment of tissue physical integrity. Recent evidence has, however, led to a paradigm shift according to which the ECM is increasingly recognised to exert a profound influence on cell behaviour, including gene expression, migration and the maintenance of functional homeostasis. The objective of this focussed review is to highlight selected observations underpinning this conclusion. Finally, we discuss the implications of these findings for regenerative medicine in the specific context of developing the 'next generation' of advanced wound care devices for the clinical management of recalcitrant chronic wounds. PMID:22421635

Keatch, Robert P; Schor, Ana M; Vorstius, Jan B; Schor, Seth L

2012-08-01

341

Regenerative medicine approach to reconstruction of the equine upper airway.  

PubMed

Airway obstruction is a common cause of poor performance in horses. Structural abnormalities (insufficient length, rigidity) can be a cause for the obstruction. Currently, there are a few effective clinical options for reconstruction of the equine larynx. A regenerative medicine approach to reconstruction may provide the capability to stabilize laryngeal structures and to encourage restoration of site-appropriate, functional, and host-derived tissue. The purpose of this study was the histopathological evaluation of (1) decellularization of equine (horse) laryngeal cartilages (epiglottis and arytenoids); (2) the host response to decellularized laryngeal cartilages implanted subcutaneously in a donkey model as a test of biocompatibility; and (3) the use of decellularized laryngeal cartilages in a clinically relevant pilot study in the horse larynx. Equine laryngeal cartilages were found to be sufficiently decellularized and were subsequently implanted subcutaneously in donkeys to test biocompatibility. After 4 weeks, the implanted cartilage was harvested. In the subcutaneous model, the samples did not elicit a rejection or foreign body type reaction and were judged suitable for implantation in a clinically relevant equine model. Implants were placed in the upper airway (arytenoids and epiglottis) of one horse. At 4 weeks, the implants were observed to remodel rapidly and were replaced by dense connective tissue with signs of new hyaline cartilage formation in the arytenoids and by connective tissue containing glandular structures and an epithelial covering in the epiglottis. The results of the present study demonstrate the feasibility of a scaffold-based regenerative medicine approach to reconstruction of the equine upper airway; however, further studies investigating long-term integration, formation of new cartilage, and mechanical properties are needed. PMID:24160675

Grevemeyer, Bernard; Bogdanovic, Lewis; Canton, Stephen; St Jean, Guy; Cercone, Marta; Ducharme, Norm G; Brown, Bryan N

2014-04-01

342

Application of Stem Cell Technology in Dental Regenerative Medicine  

PubMed Central

Significance In this review, we summarize the current literature regarding the isolation and characterization of dental tissue-derived stem cells and address the potential of these cell types for use in regenerative cell transplantation therapy. Recent Advances Looking forward, platforms for the delivery of stem cells via scaffolds and the use of growth factors and cytokines for enhancing dental stem cell self-renewal and differentiation are discussed. Critical Issues We aim to understand the developmental origins of dental tissues in an effort to elucidate the molecular pathways governing the genesis of somatic dental stem cells. The advantages and disadvantages of several dental stem cells are discussed, including the developmental stage and specific locations from which these cells can be purified. In particular, stem cells from human exfoliated deciduous teeth may act as a very practical and easily accessibly reservoir for autologous stem cells and hold the most value in stem cell therapy. Dental pulp stem cells and periodontal ligament stem cells should also be considered for their triple lineage differentiation ability and relative ease of isolation. Further, we address the potentials and limitations of induced pluripotent stem cells as a cell source in dental regenerative. Future Directions From an economical and a practical standpoint, dental stem cell therapy would be most easily applied in the prevention of periodontal ligament detachment and bone atrophy, as well as in the regeneration of dentin-pulp complex. In contrast, cell-based tooth replacement due to decay or other oral pathology seems, at the current time, an untenable approach. PMID:24527351

Feng, Ruoxue; Lengner, Chistopher

2013-01-01

343

Mesenchymal stem cell and regenerative medicine: regeneration versus immunomodulatory challenges  

PubMed Central

Mesenchymal Stem cells (MSC) are now presented with the opportunities of multifunctional therapeutic approaches. Several reports are in support of their self-renewal, capacity for multipotent differentiation, and immunomodulatory properties. They are unique to contribute to the regeneration of mesenchymal tissues such as bone, cartilage, muscle, ligament, tendon, and adipose. In addition to promising trials in regenerative medicine, such as in the treatment of major bone defects and myocardial infarction, MSC has shown a therapeutic effect other than direct hematopoiesis support in hematopoietic reconstruction. MSCs are identified by the expression of many molecules including CD105 (SH2) and CD73(SH3/4) and are negative for the hematopoietic markers CD34, CD45, and CD14. Manufacturing of MSC for clinical trials is also an important aspect as their differentiation, homing and Immunomodulatory properties may differ. Their suppressive effects on immune cells, including T cells, B cells, NK cells and DC cells, suggest MSCs as a novel therapy for GVHD and other autoimmune disorders. Since the cells by themselves are non-immunogenic, tissue matching between MSC donor and recipient is not essential and, MSC may be the first cell type able to be used as an “off-the-shelf” therapeutic product. Following a successful transplantation, the migration of MSC to the site of injury refers to the involvement of chemokines and chemokine receptors of respective specificity. It has been demonstrated that cultured MSCs have the ability to engraft into healthy as well as injured tissue and can differentiate into several cell types in vivo, which facilitates MSC to be an ideal tool for regenerative therapy in different disease types. However, some observations have raised questions about the limitations for proper use of MSC considering some critical factors that warn regular clinical use. PMID:23671814

Law, Sujata; Chaudhuri, Samaresh

2013-01-01

344

Bromodeoxyuridine specifically labels the regenerative stem cells of planarians  

E-print Network

The singular regenerative abilities of planarians require a population of stem cells known as neoblasts. In response to wounding, or during the course of cell turnover, neoblasts are signaled to divide and/or differentiate, thereby replacing lost cell types. The study of these pluripotent stem cells and their role in planarian regeneration has been severely hampered by the reported inability of planarians to incorporate exogenous DNA precursors; thus, very little is known about the mechanisms that control proliferation and differentiation of this stem cell population within the planarian. Here we show that planarians are, in fact, capable of incorporating the thymidine analogue bromodeoxyuridine (BrdU), allowing neoblasts to be labeled specifically during the S phase of the cell cycle. We have used BrdU labeling to study the distribution of neoblasts in the intact animal, as well as to directly demonstrate the migration and differentiation of neoblasts. We have examined the proposal that a subset of neoblasts is arrested in the G2 phase of the cell cycle by double-labeling with BrdU and a mitosis-specific marker; we find that the median length of G2 (?6 h) is sufficient to account for the initial mitotic burst observed after feeding or amputation. Continuous BrdU-labeling experiments also suggest that there is not a large, slow-cycling population of neoblasts in the intact animal. The ability to label specifically the regenerative stem cells, combined with the recently described use of double-stranded RNA to inhibit gene expression in the planarian, should serve to reignite interest in the flatworm as an experimental model for studying the problems of metazoan regeneration and the control of stem cell proliferation. © 2000 Academic Press Key Words: planaria; regeneration; stem cells; neoblasts; flatworms; bromodeoxyuridine.

Phillip A. Newmark; Ro Sánchez Alvarado

2000-01-01

345

Particle assemblies: toward new tools for regenerative medicine.  

PubMed

Regenerative medicine is a demanding field in terms of design and elaboration of materials able to meet the specifications that this application imposes. The regeneration of tissue is a multiscale issue, from the signaling molecule through cell expansion and finally tissue growth requiring a large variety of cues that should be delivered in place and time. Hence, the materials should be able to accommodate cells with respect to their phenotypes, to allow cell division to the right tissue, to maintain the integrity of the surrounding sane tissue, and eventually use their signaling machinery to serve the development of the appropriate neo-tissue. They should also present the ability to deliver growth factors and regulate tissue development, to be degraded into safe products, in order not to impede tissue development, and finally be easily implanted/injected into the patients. In this context, colloid-based materials represent a very promising family of products because one can take advantage of their high specific area, their capability to carry/deliver bio-active molecules, and their capacity of assembling (eventually in vivo) into materials featuring other mechanical, rheological, physicochemical properties. Other benefits of great interest would be their ease of production even via high through-put processes and their potential manufacturing from safe, biodegradable and biocompatible parent raw material. This review describes the state-of-the-art of processes leading to complex materials from the assembly of colloids meeting, at least partially, the above-described specifications for tissue engineering and regenerative medicine. PMID:23827536

Roux, R; Ladavière, C; Montembault, A; Delair, T

2013-04-01

346

Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia  

PubMed Central

Congenital adrenal hyperplasia refers to a group of autosomal recessive disorders caused by a deficiency of an enzyme involved in the synthesis of glucocorticoids. The enzyme deficiency generally leads to a deficiency of cortisol and/or aldosterone production within the adrenal cortex. The lack of glucocorticoids generally leads to elevated levels of plasma corticotropin (ACTH), which often results in adrenal hyperplasia. Testicular adrenal rest tumors may develop in males with congenital adrenal hyperplasia due to overstimulation of aberrant adrenal cells within the testes. Recognition of this disease entity is essential when evaluating young males with testicular masses. PMID:24967019

Olpin, Jeffrey Dee; Witt, Benjamin

2014-01-01

347

Benign lymphoid hyperplasia of the tongue masquerading as carcinoma: case report and literature review.  

PubMed

Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. Microscopy showed typical histologic features of multiple germinal centers with a rim of small mature lymphocytes together with a mixed, mainly mononuclear infiltrate which clinched the diagnosis of benign lymphoid hyperplasia. This diagnosis averted extensive investigations and major surgery. The etiology of these lesions is unknown. Their distinction from carcinoma and lymphoma is discussed. PMID:16127479

Carnelio, Sunitha; Rodrigues, Gabriel

2005-08-15

348

Space Station Freedom ECLSS: A step toward autonomous regenerative life support systems  

NASA Technical Reports Server (NTRS)

The Environmental Control and Life Support System (ECLSS) is a Freedom Station distributed system with inherent applicability to extensive automation primarily due to its comparatively long control system latencies. These allow longer contemplation times in which to form a more intelligent control strategy and to prevent and diagnose faults. The regenerative nature of the Space Station Freedom ECLSS will contribute closed loop complexities never before encountered in life support systems. A study to determine ECLSS automation approaches has been completed. The ECLSS baseline software and system processes could be augmented with more advanced fault management and regenerative control systems for a more autonomous evolutionary system, as well as serving as a firm foundation for future regenerative life support systems. Emerging advanced software technology and tools can be successfully applied to fault management, but a fully automated life support system will require research and development of regenerative control systems and models. The baseline Environmental Control and Life Support System utilizes ground tests in development of batch chemical and microbial control processes. Long duration regenerative life support systems will require more active chemical and microbial feedback control systems which, in turn, will require advancements in regenerative life support models and tools. These models can be verified using ground and on orbit life support test and operational data, and used in the engineering analysis of proposed intelligent instrumentation feedback and flexible process control technologies for future autonomous regenerative life support systems, including the evolutionary Space Station Freedom ECLSS.

Dewberry, Brandon S.

1990-01-01

349

Initial human clinical experience with diode laser interstitial treatment of benign prostatic hyperplasia  

Microsoft Academic Search

ObjectivesTo report the initial results of treatment of outlet obstruction induced by benign prostatic hyperplasia (BPH) using interstitial laser coagulation performed with the Indigo 830 nm diode laser system.

Rolf Muschter; Jean J. M. C. H. De La Rosette; Hugh Whitfield; Jean-Pierre Pellerin; Stephan Madersbacher; David Gillatt

1996-01-01

350

Holmium laser enucleation versus open prostatectomy for benign prostatic hyperplasia: An inpatient cost analysis  

Microsoft Academic Search

ObjectivesTo compare the cost of open transvesical prostatectomy (OP) with that of holmium laser enucleation (HoLEP) in the treatment of bladder outlet obstruction (BOO) attributed to benign prostatic hyperplasia.

Andrea Salonia; Nazareno Suardi; Richard Naspro; Bruno Mazzoccoli; Giuseppe Zanni; Andrea Gallina; Lina Bua; Vincenzo Scattoni; Patrizio Rigatti; Francesco Montorsi

2006-01-01

351

Focal nodular hyperplasia and hepatic adenoma: comparison of angiography, CT, US, and scintigraphy  

SciTech Connect

The authors reviewed 23 cases of focal nodular hyperplasia and 13 cases of hepatic adenoma, all of which were confirmed pathologically. All solitary masses that exhibited normal or increased uptake of technetium 99m-sulfur colloid were shown to be hyperplasia; while previous criteria such as a central blood supply on angiograms or a central scar on computed tomography (CT) or ultrasound (US) scans were helpful, they were relatively infrequent. A mass that was slightly hypodense and homogeneous on a CT or US scan and highly vascular with an intense capillary stain on an angiogram was almost always hyperplasia. Acute hemorrhage within a focal hepatic tumor was common in adenoma but did not occur in hyperplasia.

Welch, T.J.; Sheedy, P.F. II; Johnson, C.M.; Stephens, D.H.; Charboneau, J.W.; Brown, M.L.; May, G.R.; Adson, M.A.; McGill, D.B.

1985-09-01

352

Unknown syndrome: microcephaly, hypoplastic nose, exophthalmos, gum hyperplasia, cleft palate, low set ears, and osteosclerosis  

Microsoft Academic Search

We report a neonate, born at term, with microcephaly, a hypoplastic nose, exophthalmos, gum hyperplasia, cleft palate, and low set ears, who died at 86 minutes of age. Radiographs showed diffuse sclerosis of the bones.

J Raine; R M Winter; A Davey; S M Tucker

1989-01-01

353

Long-term 6-year experience with finasteride in patients with benign prostatic hyperplasia  

Microsoft Academic Search

ObjectivesTo summarize the 6-year clinical trial data with finasteride. Benign prostatic hyperplasia is a chronic and progressive disease and therefore assessment of long-term safety and efficacy is important.

Franklin C Lowe; John D McConnell; Perry B Hudson; Nicholas A Romas; Rex Boake; Michael Lieber; Mostafa Elhilali; Jack Geller; Juliane Imperto-McGinely; Gerald L Andriole; Reginald C Bruskewitz; Patrick C Walsh; Georg Bartsch; John N Nacey; Sukrut Shah; Frances Pappas; Amy Ko; Thomas Cook; Elizabeth Stoner; Joanne Waldstreicher

2003-01-01

354

Radioactive stents delay but do not prevent in-stent neointimal hyperplasia  

Microsoft Academic Search

BACKGROUND: Restenosis after conventional stenting is almost exclusively caused by neointimal hyperplasia. Beta-particle-emitting radioactive stents decrease in-stent neointimal hyperplasia at 6-month follow-up. The purpose of this study was to evaluate the 1-year outcome of (32)P radioactive stents with an initial activity of 6 to 12 microCi using serial quantitative coronary angiography and volumetric ECG-gated 3D intravascular ultrasound (IVUS). METHODS AND

I. Patrick Kay; Alexander J. Wardeh; Ken Kozuma; A. H. M. Knook; A. Thury; P. W. J. C. Serruys; D. P. Foley; P. C. Levendag; Giessen van der W. J; G. Sianos

2001-01-01

355

Paclitaxel Stent Coating Inhibits Neointimal Hyperplasia at 4 Weeks in a Porcine Model of Coronary Restenosis  

Microsoft Academic Search

Background—Despite limiting elastic recoil and late vascular remodeling after angioplasty, coronary stents remain vulnerable to restenosis, caused primarily by neointimal hyperplasia. Paclitaxel, a microtubule-stabilizing drug, has been shown to inhibit vascular smooth muscle cell migration and proliferation contributing to neointimal hyperplasia. We tested whether paclitaxel-coated coronary stents are effective at preventing neointimal proliferation in a porcine model of restenosis. Methods

Alan W. Heldman; Linda Cheng; G. Mark Jenkins; Phillip F. Heller; Dong-Woon Kim; Melvin Ware; Cynthia Nater; Ralph H. Hruban; Banafsheh Rezai; Benjamin S. Abella; Katherine E. Bunge; James L. Kinsella; Steven J. Sollott; Edward G. Lakatta; Jeffrey A. Brinker; William L. Hunter; Jeffrey P. Froehlich

2010-01-01

356

The effects of Toradol on postoperative intimal hyperplasia in a rat carotid endarterectomy model: laboratory research.  

PubMed

Carotid endarterectomy (CEA) and more recently carotid artery stenting are the treatments of choice for atherosclerotic disease of the extracranial carotid arteries; however, early restenosis caused by neointimal hyperplasia confounds surgical therapy. Oxidative stress has been implicated in the progression of intimal hyperplasia. The authors hypothesized that ketorolac tromethamine (Toradol), a nonsteroidal antiinflammatory drug that is a potent cyclooxygenase inhibitor, would decrease oxidative stress and thereby reduce intimal hyperplasia in a rat CEA model. Twenty-nine male Sprague-Dawley rats underwent CEA and were divided into 3 treatment groups as follows: (1) control (placebo), (2) 7.5 mg/kg Toradol, and (3) 10 mg/kg Toradol. Toradol treatment began 2 days before CEA and continued for 2 weeks. Two weeks after endarterectomy, carotid arteries were fixed, harvested, and examined for platelet activity (platelet reactive units), oxidative stress (malondialdehyde and glutathione), and intimal hyperplasia (measured as percentage of luminal stenosis). Platelet activity, malondialdehyde and glutathione, and intimal hyperplasia were all significantly lowered in both 7.5- and 10-mg/kg doses of Toradol versus control. Toradol given daily beginning 2 days before CEA and ending 2 weeks after the procedure was effective at significantly reducing platelet activity, oxidative stress, and intimal hyperplasia development in the rat without any increase in bleeding. Although the mechanism of action of this reduction is not completely understood, one possible explanation may be through the inhibition of reactive oxygen species production. PMID:17942855

Kalapatapu, Venkat R; Satterfield, Leighton; Brown, Aliza T; Hongjiang Chen; Ercal, Nuran; Price, Tulin O; Jie Gao; Ibrahim, Khalil; Moursi, Mohammed M

2007-01-01

357

Soy Protein Scaffold Biomaterials for Tissue Engineering and Regenerative Medicine  

NASA Astrophysics Data System (ADS)

Developing functional biomaterials using highly processable materials with tailorable physical and bioactive properties is an ongoing challenge in tissue engineering. Soy protein is an abundant, natural resource with potential use for regenerative medicine applications. Preliminary studies show that soy protein can be physically modified and fabricated into various biocompatible constructs. However, optimized soy protein structures for tissue regeneration (i.e. 3D porous scaffolds) have not yet been designed. Furthermore, little work has established the in vivo biocompatibility of implanted soy protein and the benefit of using soy over other proteins including FDA-approved bovine collagen. In this work, freeze-drying and 3D printing fabrication processes were developed using commercially available soy protein to create porous scaffolds that improve cell growth and infiltration compared to other soy biomaterials previously reported. Characterization of scaffold structure, porosity, and mechanical/degradation properties was performed. In addition, the behavior of human mesenchymal stem cells seeded on various designed soy scaffolds was analyzed. Biological characterization of the cell-seeded scaffolds was performed to assess feasibility for use in liver tissue regeneration. The acute and humoral response of soy scaffolds implanted in an in vivo mouse subcutaneous model was also investigated. All fabricated soy scaffolds were modified using thermal, chemical, and enzymatic crosslinking to change properties and cell growth behavior. 3D printing allowed for control of scaffold pore size and geometry. Scaffold structure, porosity, and degradation rate significantly altered the in vivo response. Freeze-dried soy scaffolds had similar biocompatibility as freeze-dried collagen scaffolds of the same protein content. However, the soy scaffolds degraded at a much faster rate, minimizing immunogenicity. Interestingly, subcutaneously implanted soy scaffolds affected blood glucose and insulin sensitivity levels. Furthermore, soy scaffolds implanted in the intraperitoneal cavity attached to adjacent liver tissue with no abnormalities. In vitro, soy scaffolds supported hMSC viability and transdifferentiation into hepatocyte-like cells. These results support the use of soy scaffolds for liver tissue engineering and for treating metabolic diseases. Based on achievable structural and mechanical properties, as well as systemic effects of ingested and degraded soy proteins, soy protein scaffolds may serve as new multifunctional biomaterials for tissue engineering and regenerative medicine.

Chien, Karen B.

358

Feeding and healing the world: through regenerative agriculture and permaculture.  

PubMed

The study of soil is a mature science, whereas related practical methods of regenerative agriculture and permaculture are not. However, despite a paucity of detailed peer reviewed research published on these topics, there is overwhelming evidence both that the methods work and they may offer the means to address a number of prevailing environmental challenges, e.g. peak oil, climate change, carbon capture, unsustainable agriculture and food shortages, peak phosphorus (phosphate), water shortages, environmental pollution, desert reclamation, and soil degradation. What is lacking is a proper scientific study, made in hand with actual development projects. By elucidating the scientific basis of these remarkable phenomena, we may obtain the means for solving some of the otherwise insurmountable problems confronting humanity, simply by observing, and working with, the patterns and forces of nature. This article is intended as a call to arms to make serious investment in researching and actualising these methods on a global scale. Despite claims that peak oil is no longer a threat because vast resources of gas and shale oil (tight oil) can now be recovered by fracking (hydraulic fracturing) combined with horizontal drilling, the reality is that proven actual reserves are only adequate to delay the peak by a few years. Furthermore, because of the rapid depletion rates of flow from gas wells and oil wells that are accessed by fracking, it will be necessary to drill continuously and relentlessly to maintain output, and there are material limits of equipment, technology and trained personnel to do this. Moreover, to make any sensible difference to the liquid fuel crisis, which is the most immediate consequence of peak oil, it would be necessary to convert the worlds one billion vehicles to run on natural gas rather than liquid fuels refined from crude oil, and this would take some considerable time and effort. The loss of widespread personalised transportation is thus inevitable and imminent, meaning a loss of globalised civilisation and a mandatory return to living in smaller localised communities. Permaculture and regenerative agriculture offer potentially the means to provide food and materials on the small scale, and address the wider issues of carbon emissions, and resource shortages. Since over half the World's population lives in cities, it seems likely that strengthening the resilience of these environments, using urban permaculture, may be a crucial strategy in achieving a measured descent in our use of energy and other resources, rather than an abrupt collapse of civilization. PMID:23469709

Rhodes, Christopher J

2012-01-01

359

Surface Fine Grinding via a Regenerative Grinding Methodology  

NASA Astrophysics Data System (ADS)

This paper presents a regenerative surface fine grinding methodology to remove grinding defects of traditional operations and to improve the quality of surface flatness. All possible surface defects produced by traditional and creep-feed grinding operations are carefully reviewed and circumvented. These defects include non -uniform traces, pitting spots, scratches, burnouts, and quenching breakage. To alleviate these traditional grinding defects, the paper presents a new approach by designing and constructing a regenerative surface fine grinding system that includes a mechanism that carries the submerged workpart in an oil-contained open box. The fine grinding tool held by the spindle-chuck unit of the CNC machine is moved in relative to the workpart surfaces by a combined trajectory of a cycloid path, a linear feed and a lateral travel. Some numerical simulations for selecting appropriate grinding trajectories are presented and simulated. The trajectory is selected based upon the resulting quality of contact uniformity and homogeneity as expressed in terms of contact frequency to each point on the workpart surface. The simulation model is then used to characterize appropriate working range of each grinding parameter. Different grinding paths are thus generated and superposed. A working machine is designed and built based upon the simulation results. Several experiments are carried out on the constructed grinding system with the grinding tool mounted to the spindle-chuck unit of the CNC machine. The surface quality of the ground workpart is measured. Tests on different system parameters demonstrate the importance of choosing the correct grinding wheel and grit size and an illustration of the proper selection of process and system parameters are presented. The experimental results are compared with those of analytical solutions. Good agreement between them is observed. In ninety minutes fine-grinding operations using the proposed method, the workpart surfaces generally possess no damage and surface roughness is reduced to the range of 0.02~0.04?m in Ra. To verify the effectiveness of the proposed method, the results of fine grinding operations using various process parameters are measured and recorded. The effects of various combinations of process parameters including trajectory density, uniformity and grinding efficiency on the effect of surface flatness enhancement are carefully examined and concluded.

Lai, Hsin-Yi; Chen, Chao'-Kuang

2006-10-01

360

A study of the effect of variable speed machining on regenerative chatter in end milling  

E-print Network

The objective of the research is to study the practical application of Variable Speed Machining (VSM) as a strategy to control regenerative chatter in end milling. In this research, experiments are conducted on a Bridgeport Discovery Torq-Cut 22...

Dhayalan, Arun Kumar

2012-06-07

361

Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances  

E-print Network

In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of the cells have a direct effect on cells’ behaviour and subsequently on clinical outcomes. Physical, chemical, and biological ...

Barthes, Julien

362

Wound Healing Versus Regeneration: Role of the Tissue Environment in Regenerative Medicine  

E-print Network

One of the major challenges in the field of regenerative medicine is how to optimize tissue regeneration in the body by therapeutically manipulating its natural ability to form scar at the time of injury or disease. It is ...

Atala, Anthony

363

Is it economically feasible to use heterogeneous catalysts for VOC control in regenerative oxidizers?  

Microsoft Academic Search

A method of VOC control based on the use of reverse-flow operation in a fixed catalyst bed is compared with high temperature regenerative incineration. The selection of the optimal VOC control system is discussed.

Yurii Sh. Matros; Grigori A. Bunimovich; Stephen E. Patterson; Steven F. Meyer

1996-01-01

364

Definition study for an extended manned test of a regenerative life support system, preliminary test plan  

NASA Technical Reports Server (NTRS)

A preliminary plan and procedure are presented for conducting an extended manned test program for a regenerative life support system. Emphasis will be placed on elements associated with long-term system operation and long-term uninterrupted crew confinement.

1971-01-01

365

Regenerative wavelength conversion using optical flip-flop outputs of multimode interference bistable laser diodes  

Microsoft Academic Search

Regenerative wavelength conversion was obtained using multimode interference bistable laser diodes and cross gain saturation in semiconductor optical amplifiers. A digital transfer function of wavelength conversion was achieved through the optical flip-flop thresholding function

M. Takenaka; M. Raburn; Y. Nakano

2005-01-01

366

Regenerative neurogenesis from neural progenitor cells requires injury-induced expression of Gata3.  

PubMed

The adult zebrafish brain, unlike mammalian counterparts, can regenerate after injury owing to the neurogenic capacity of stem cells with radial glial character. We hypothesized that injury-induced regenerative programs might be turned on after injury in zebrafish brain and enable regenerative neurogenesis. Here we identify one such gene-the transcription factor gata3-which is expressed only after injury in different zebrafish organs. Gata3 is required for reactive proliferation of radial glia cells, subsequent regenerative neurogenesis, and migration of the newborn neurons. We found that these regeneration-specific roles of Gata3 are dependent on the injury because Gata3 overexpression in the unlesioned adult zebrafish brain is not sufficient to induce neurogenesis. Thus, gata3 acts as a specific injury-induced proregenerative factor that is essential for the regenerative capacity in vertebrates. PMID:23168169

Kizil, Caghan; Kyritsis, Nikos; Dudczig, Stefanie; Kroehne, Volker; Freudenreich, Dorian; Kaslin, Jan; Brand, Michael

2012-12-11

367

Regenerative activity of 2-(1'-hydroxy-4'-isopropenyl-1'-methylcyclohexyl-2'-thio) methyl ethanoate gel.  

PubMed

We studied regenerative activity of a sulfur-containing menthane terpenoid (2-(1'-hydroxy-4'-isopropenyl-1'-methylcyclohexyl-2'-thio) methyl ethanoate) in the form of gels with different concentrations in experimental superficial non-penetrating corneal wound. The examined compound significantly increased the regenerative activity by accelerating the onset and completion of epithelialization. The use of 2% and 3% gel ensured finer scarring. PMID:24143366

Akulina, I V; Pozdeeva, N A; Frolychev, I A; Shikhanov, A O; Ovchinnikova, V N

2013-08-01

368

Highly Stable, All-Solid-State Nd:YLF Regenerative Amplifier  

SciTech Connect

A diode-pumped Nd:YLF regenerative amplifier (regen) has been developed and is in use in the 60-beam, 30-kJUV OMEGA laser system's driver line. The high stability, compactness, and reliability of this all-solid-state modular design are the key features of this concept. Stable, millijoule-level output-pulse energies with an overall gain of 109 have been demonstrated.

Okishev,A.V.; Zuegel,J.D.

2004-11-20

369

Analysis of a regenerative braking system for Hybrid Electric Vehicles using an ElectroMechanical Brake  

Microsoft Academic Search

The regenerative braking system of the Hybrid Electric Vehicle (HEV) is a key technology that can improve fuel efficiency\\u000a by 20?50%, depending on motor size. In the regenerative braking system, the electronically controlled brake subsystem that\\u000a directs the braking forces into four wheels independently is indispensable. This technology is currently found in the Electronic\\u000a Stability Program (ESP) and in Vehicle

J. K. Ahn; K. H. Jung; D. H. Kim; H. B. Jin; H. S. Kim; S. H. Hwang

2009-01-01

370

Regenerative braking control strategy in mild hybrid electric vehicles equipped with automatic manual transmission  

Microsoft Academic Search

The actual regenerative braking force of an integrated starter\\/generator (ISG), which is varied with desired braking deceleration\\u000a and vehicle speed, is calculated based on an analysis of the required deceleration, maximum braking force of ISG, engine braking\\u000a force and state of charge (SOC) of battery. Braking force distribution strategies are presented according to the actual regenerative\\u000a braking force of ISG.

Datong Qin; Ming Ye; Zhenjun Liu

2007-01-01

371

Effective regenerative braking control for smooth stop of a hybrid electric bus  

Microsoft Academic Search

Regenerative braking is an important function for a hybrid electric bus with many stop-to-go drive conditions. Yet an accurate nonlinear model for the composite brake system in HEV and a nonlinear model-based control design for a series-parallel hybrid electric bus have not been fully studied. This paper describes the brake system with regenerative braking function, and a special brake pedal

Jie Shu; Weiwei Xiong; Chengliang Yin; Yong Zhang

2008-01-01

372

Alkaline RFC Space Station prototype - 'Next step Space Station'. [Regenerative Fuel Cells  

NASA Technical Reports Server (NTRS)

The regenerative fuel cell, a candidate technology for the Space Station's energy storage system, is described. An advanced development program was initiated to design, manufacture, and integrate a regenerative fuel cell Space Station prototype (RFC SSP). The RFC SSP incorporates long-life fuel cell technology, increased cell area for the fuel cells, and high voltage cell stacks for both units. The RFC SSP's potential for integration with the Space Station's life support and propulsion systems is discussed.

Hackler, I. M.

1986-01-01

373

Comparative studies on plant range size: Linking reproductive and regenerative traits in two Ipomoea species  

Microsoft Academic Search

Reproductive and regenerative traits associated with colonization and persistence ability may determine plant range size. However, few comparative studies on plant distribution have assessed these traits simultaneously. Pollinator richness and frequency of visits, autonomous self-pollination ability, reproductive output (i.e., reproductive traits), seed bank strategy and seedling density (i.e., regenerative traits) were compared between the narrowly distributed Ipomoea rubriflora O’Donnell (Convolvulaceae)

Julia Astegiano; Guillermo Funes; Leonardo Galetto

2010-01-01

374

An automatic pulse alignment method for slope controlled super-regenerative receiver systems  

Microsoft Academic Search

Recently there is an increase in interest for using super-regenerative receivers for pulse based communication systems. To receive a pulse using the super-regenerative architecture the pulse needs to be aligned with the zero crossing of the damping co-efficient (which depends on the quench signal) for achieving maximum sensitivity. In general, the pulse to be received is not aligned with the

P. E. Thoppay; C. Dehollain; M. J. Declercq

2007-01-01

375

Structural characterization of [(?-H)Os 3(CO) 10(?-NH 2)] and a new polymorphic form of [(?-H)Os 3(CO) 10(?-SH)]. Influence of the bridging group on the geometry of compounds [(?-H)Os 3(CO) 10(?-X)] (X = NH 2, NRH, PRH, SbR 2, OH, SH, SR, SeR, Cl, Br). Reactions of [(?-H)Os 3(CO) 10(?-X)] (X = OH and SH) with proton sponge  

NASA Astrophysics Data System (ADS)

Compounds [(?-H)Os 3(CO) 10(?-NH 2)] and a new polymorphic form of [(?-H)Os 3(CO) 10(?-SH)] were obtained from the reaction of [H 2Os 3(CO) 10] with 1,3,5-N,N,N,-trimethyl-triazinane and 1,3,5-trithiane respectively. The structures show the same geometry described for other doubly bridged triangular clusters. A comparison of these type of compounds show that the bridging group does not affect significantly the dihedral angle between Os 3 and Os 2X planes (X = NH 2, NRH, PRH, SbR 2, OH, OR, SH, SR, SeR, Cl and Br). The presence of a hydrogen atom on the bridge could favor a possible interaction between groups so the crystal packing is analyzed. Since intermolecular interactions could also be occurring in solution, reactions of [(?-H)Os 3(CO) 10(?-OH)] and [(?-H)Os 3(CO) 10(?-SH)] with proton sponge were carried out in order to determine if the OH or SH protons had acidic character and could react with a base. These results and other structural characteristics will be discussed.

Reyes-López, Ottmar R.; Leyva, Marco A.; Rosales-Hoz, María J.

2011-01-01

376

Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome  

PubMed Central

Background: Kaempferia parviflora rhizome is used as a folk medicine in Thailand for the treatment of various symptoms. In the present study, the inhibitory activities of extract from K. parviflora rhizome against 5?-reductase (5?R) were subjected. Furthermore, the effects of the extract from K. parviflorar hizome in benign prostate hyperplasia (BPH) were studied using the model mice. Materials and Methods: Preparations of extracts from the rhizomes of K. parviflora, Curcuma zedoaria and Zingiber officinale, and methoxyflavones isolated from K. parviflora was used for 5?R inhibition assay. The effects of K. parviflora extract on growth suppression for the prostates and seminal vesicles were performed based on the Hershberger's method. The K. parviflora extract was administered to castrated mice for 14 days. Results: K. parviflora extract showed more potent inhibitory activity on 5?R than C. zedoaria and Z. officinale extracts. The active principles were identified as 3,5,7,3’,4’-pentamethoxyflavone and 5,7,3’,4’-tetramethoxyflavone by activity guided fractionation. Furthermore, K. parviflora extract suppressed the weights of prostates and seminal vesicles in BPH model rats by daily administration for 14 days. Conclusion: These results indicate that K. parviflora extract can be a promising agent for the treatment of BPH. PMID:24174827

Murata, Kazuya; Hayashi, Hirotaka; Matsumura, Shinichi; Matsuda, Hideaki

2013-01-01

377

Impact of molecular genetics on congenital adrenal hyperplasia management.  

PubMed

Congenital adrenal hyperplasia (CAH) is a family of autosomal recessive disorders caused by mutations in genes encoding the enzymes involved in one of the 5 steps of adrenal steroid synthesis or the electron donor P450 oxidoreductase (POR) enzyme. Steroid 21-hydroxylase deficiency (21-OHD), the principal focus of this review, accounts for about 90-95% of all CAH cases, and its biochemical and clinical severity depends on the underlying CYP21A2 gene disruption. Molecular genetic advancements have been achieved in recent years, and the aim of this review is to attempt to highlight its contribution to the comprehension and management of the disease. When possible, we will try to achieve this goal also by providing some results from our personal experience regarding: some aspects of CYP21A2 gene analysis, with basic genotype/phenotype relationships; its crucial role in both genetic counselling and in prenatal diagnosis and treatment in families at risk for 21-OHD; its help in the comprehension of the severity of the disease in patients diagnosed by neonatal screening and possibly treated before an evident salt-loss crisis or before performing adequate blood sampling; its usefulness in the definition of post ACTH 17-hydroxyprogesterone values, discriminating between non-classic, heterozygote and normal subjects; and finally the contribution of genes other than CYP21A2 whose function or dysfunction could influence 21-hydroxylase activity and modify the presentation or management of the disease. PMID:20639616

Balsamo, A; Baldazzi, L; Menabò, S; Cicognani, A

2010-09-01

378

Giant Bilateral Adrenal Myelolipoma with Congenital Adrenal Hyperplasia  

PubMed Central

Myelolipomas are rare and benign neoplasms, predominant of the adrenal glands, consisting of adipose and mature hematopoietic tissue, commonly discovered incidentally with increased use of radiologic imaging. Few cases of giant bilateral adrenal masses are reported, especially in the setting of congenital adrenal hyperplasia (CAH). We report the case of a 39-year-old male with a history of CAH secondary to 21-? hydroxylase deficiency on steroids since childhood, self-discontinued during adolescence, presenting with abdominal distension, fatigue, decreased libido, and easy bruising. Imaging revealed giant bilateral adrenal masses. He subsequently underwent bilateral adrenalectomy found to be myelolipomas measuring 30 × 25 × 20?cm on the left and weighing 4.1?kg and 25 × 20 × 13?cm on the right and weighing 2.7?kg. Adrenal myelolipomas are found to coexist with many other conditions such as Cushing's syndrome, Addison's disease, and CAH. We discuss the association with high adrenocorticotropic hormone (ACTH) states and review the studies involving ACTH as proponent leading to myelolipomas. Massive growth of these tumors, as in our case, can produce compression and hemorrhagic symptoms. We believe it is possible that self-discontinuation of steroids, in the setting of CAH, may have resulted in the growth of his adrenal masses. PMID:25140269

Al-Bahri, S.; Tariq, A.; Lowentritt, B.; Nasrallah, D. V.

2014-01-01

379

Therapeutic strategies to combat neointimal hyperplasia in vascular grafts.  

PubMed

Neointimal hyperplasia (NIH) in bypass conduits such as veins and prosthetic grafts is an important clinical entity that limits the long-term success of vascular interventions. Although the development of NIH in the conduits shares many of the same features of NIH that develops in native arteries after injury, vascular grafts are exposed to unique circumstances that predispose them to NIH, including surgical trauma related to vein handling, hemodynamic changes creating areas of low flow, and differences in biocompatibility between the conduit and the host environment. Multiple different approaches, including novel surgical techniques and targeted gene therapies, have been developed to target and prevent the causes of NIH. Recently, the PREVENT trials, the first molecular biology trials in vascular surgery aimed at preventing NIH, have failed to produce improved clinical outcomes, highlighting the incomplete knowledge of the pathways leading to NIH in vascular grafts. In this review, we aim to summarize the pathophysiologic pathways that underlie the formation of NIH in both vein and synthetic grafts and discuss current and potential mechanical and molecular approaches under investigation that may limit NIH in vascular grafts. PMID:22651839

Collins, Michael J; Li, Xin; Lv, Wei; Yang, Chenzi; Protack, Clinton D; Muto, Akihito; Jadlowiec, Caroline C; Shu, Chang; Dardik, Alan

2012-05-01

380

Benign prostatic hyperplasia: An overview of existing treatment  

PubMed Central

Benign prostatic hyperplasia (BPH) is the most common condition in aging men, associated with lower urinary tract symptoms (LUTS). A better understanding of the prostate physiology, function, and pathogenesis has led to the development of promising agents, useful in the management of LUTS in men. The specific approach used to treat BPH depends upon number of factors like age, prostrate size, weight, prostate-specific antigen level, and severity of the symptoms. 5?-reductase inhibitors decrease the production of dihydrotestosterone within the prostate, which results in decreased prostate volume, increased peak urinary flow rate, improvement of symptoms, decreased risk of acute urinary retention, and need for surgical intervention. ?1-adrenergic receptor (?1-AR) antagonists decrease LUTS and increase urinary flow rates in men with symptomatic BPH, but do not reduce the long-term risk of urinary retention or need for surgical intervention. Clinical efficacy of either 5?-reductase inhibitor or ?1-AR antagonist has been further improved by using combination therapy; however, long-term outcomes are still awaited. Many more potential new therapies are under development that may improve the treatment of BPH. This article gives a brief account of rationale and efficacy of different treatment options presently available in the management of BPH. PMID:21455413

Dhingra, Neelima; Bhagwat, Deepak

2011-01-01

381

Research on focal nodular hyperplasia with MSCT and postprocessing  

PubMed Central

AIM: To investigate and evaluate the pathological features and diagnostic value of focal nodular hyperplasia (FNH) with multi-section spiral computed tomography (MSCT) and postprocessing. METHODS: A total of 25 patients with FNH who had undergone MSCT and postprocessing were included in the investigation. All patients had been pathologically or clinically confirmed with FNH. A number of 75 cases of hepatic carcinomas, hemangiomas and adenomas were randomly selected at a same period for a comparative study. RESULTS: There was a single focus in 22 cases and multiple foci in 3 cases. On the plain scan, 17 lesions showed hypodensity, 7 isodensity and 4 hyperdensity (the case with fatty liver). With contrast, 28 lesions were enhanced evenly or in the nodules in the arterial phase; 13 lesions still showed hyperdensity, 11 lesions isodensity and 4 lesions hypodensity in the parenchymatous phase; in the delayed phase only 5 lesions showed hyperdensity but 9 lesions showed isodensity or slight hypodensity and 14 lesions showed hypodensity. Twelve lesions of 28 had central asteroid scars. Thickened feeding arteries in postprocessing were seen in 24 lesions, and were integrated into the parenchymatous lesions with a gradual and smooth course. On the contrary, there were no artery penetrated into the lesion found in any of comparative hepatic tumors. CONCLUSION: Doctors could make a correct diagnosis and differentiation of FNH on evaluation of the characteristic appearance on MSCT with postprocessing. PMID:19824121

Liu, Yuan-Jian; Fan, Wei-Jun; Yuan, Zhi-Dong; Liu, Peng-Cheng; Wang, Chun-Rong; Yan, Wei-Qiang; Wang, Su-Mei; Chen, Jun-Hui; Liu, Zheng

2009-01-01

382

Propranolol: a novel treatment for angiolymphoid hyperplasia with eosinophilia.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, idiopathic disease that manifests as dermal or subcutaneous red or brown papules or nodules, most commonly on the head and neck. Histologically, ALHE is characterized by vascular proliferation with epithelioid endothelial cells with surrounding lymphocytic and eosinophilic infiltrate. There may be an accompanying serum eosinophilia and local lymphadenopathy. We report a case of a 32-year-old woman who presented with multiple erythematous nodules in the periauricular area and the vertex of her scalp. The nodules had been present for several months. Surgical removal of one of the lesions confirmed the histological diagnosis of ALHE. The patient was started on oral propranolol (40 mg once daily) in an effort to reduce the vascular component of the lesions. Within 6 weeks, the patient noted that several of the lesions had decreased in size, and all were less erythematous. Propranolol was subsequently stopped within a few months of initiating treatment. One lesion recurred over a year later, and propranolol was then restarted. No new lesions occurred after 2 years of follow-up. PMID:25065811

Horst, C; Kapur, N

2014-10-01

383

Smooth muscle cell hypertrophy versus hyperplasia in hypertension.  

PubMed Central

Arteries of hypertensive animals have a greater mass of smooth muscle than those of normotensive controls. We examined the contribution of smooth muscle cell hypertrophy and hyperplasia to this increase in mass. Cell size measurements obtained by (i) image analysis of enzyme-dispersed cells, (ii) morphometric evaluation of tissue sections, and (iii) biochemical measures of protein/cell and actin/cell ratios on isolated cells showed that average cell size was greater in spontaneously hypertensive rats than in normotensive Wistar-Kyoto and Sprague-Dawley controls. Average DNA/cell ratios were also increased in spontaneously hypertensive rats while protein/DNA ratios were not different. Analysis of nuclear DNA content of individual cells by flow microfluorimetry and Feulgen-DNA microdensitometry measurements showed that greater than 20% of spontaneously hypertensive rats cells were polyploid while less than 10% of control cells were polyploid. Estimates of cell number per centimeter of aortic length, based on ploidy and DNA content, show no difference between control and hypertensive rats. Thus, smooth muscle hypertrophy alone accounts for the increased mass of smooth muscle in aortas of spontaneously hypertensive rats. Furthermore, this cellular hypertrophy is accompanied by a change in nuclear ploidy. This nuclear response in hypertension may represent a fixed change related to the establishment of a chronic hypertensive state. PMID:6950415

Owens, G K; Rabinovitch, P S; Schwartz, S M

1981-01-01

384

Increased Infiltrated Macrophages in Benign Prostatic Hyperplasia (BPH)  

PubMed Central

Infiltrated macrophages may play important roles in the development and progression of benign prostatic hyperplasia (BPH), but the underlying mechanisms remain largely unknown. We found increased macrophages infiltration in human and mouse BPH tissues. By establishing a co-culture transwell system, we found increased migration of macrophages and proliferation of prostate stromal cells during co-culture. Importantly, stromal androgen receptor (AR) could enhance the migration of macrophages and macrophage-mediated stromal cell proliferation. We identified CCL3 as an AR downstream player, and found CCL3 levels were notably increased in human and mouse BPH prostates. Ablation of prostate stromal AR in a mouse BPH model significantly reduced CCL3 expression levels in prostates. Consistently, targeting AR via an AR degradation enhancer, ASC-J9§, or neutralization of CCL3 with an antibody, resulted in suppression of macrophage migration and prostate stromal cell growth. Our study provides mechanistic insights on the regulation of prostate stromal cells by macrophages via stromal AR/CCL3 signaling pathways, which could potentially allow the development of therapeutic approaches for battling BPH with persistent inflammation. PMID:22474290

Wang, Xiaohai; Lin, Wen-Jye; Izumi, Kouji; Jiang, Qi; Lai, Kuo-Pao; Xu, Defeng; Fang, Lei-Ya; Lu, Tianjing; Li, Lei; Xia, Shujie; Chang, Chawnshang

2012-01-01

385

Photoselective vaporization of the prostate for treating benign prostatic hyperplasia.  

PubMed

Benign prostatic hyperplasia (BPH) commonly occurs in older men. Traditionally, the gold standard for treatment of BPH has been the electrocautery-based transurethral resection of the prostate (TURP). However, TURP is associated with several complications and side effects. Therefore, there is an interest in a number of emerging minimally invasive therapies as alterative treatment options. Advancements in laser technology have led to the introduction of photoselective vaporization of the prostate (PVP) using the GreenLight™ laser (American Medical Systems, MN, USA). PVP uses a 532-nm laser to remove obstructive prostatic tissue. The laser energy is selectively absorbed by hemoglobin in the prostate tissue and results in tissue destruction. The GreenLight PVP laser system has gone through several evolutions from the original 60-W laser to the most recent 180-W GreenLight XPS™ system with MoXy™ Fiber. With the increasing use of GreenLight to treat BPH, there is a need to review the evidence regarding its use. We review the clinical implications of using GreenLight laser therapy for the treatment of BPH. PMID:22026624

Chughtai, Bilal; Te, Alexis

2011-09-01

386

Micro and bulk analysis of prostate tissues classified as hyperplasia  

NASA Astrophysics Data System (ADS)

BPH (Benign Prostatic Hyperplasia) is the most common benign neoplasm (non cancerous enlargement of the prostate gland), whose prevalence increases with age. The gland, when increased in size, exerts pressure on the urethra, causing obstruction to urine flow. The latter may result in severe urinary tract and kidney conditions. In this work prostate samples from patients diagnosed with BPH were analyzed using synchrotron radiation. Micro-analysis of the hyperplastic samples was carried out on the L-beam line at HASYLAB, DESY (Germany), while bulk analysis on selected samples was performed at the DRX2 beamline at LNF, Frascati (Italy). Microanalysis with a mono-energetic beam 15 ?m in diameter confirmed that concentrations of certain elements, such as S, Mn, Cu, Fe and Zn, are good indicators of pathological disorders in prostate tissue that may be considered effective tracers of developing compliant. The concentrations of Mn, Cu, Fe and Zn are higher in hyperplastic tissues, as compared to normal ones, while for sulphur the opposite is observed. Additionally, Fe and S K-edge XANES (X-ray Absorption Near Edge Structure) spectroscopy experiments were carried out in order to determine the chemical speciation of these elements in our samples.

Kwiatek, W. M.; Bana?, A.; Bana?, K.; Cinque, G.; Dyduch, G.; Falkenberg, G.; Kisiel, A.; Marcelli, A.; Podgórczyk, M.

2007-07-01

387

Approach to the Patient: The Adult With Congenital Adrenal Hyperplasia  

PubMed Central

The most common form of congenital adrenal hyperplasia is steroid 21-hydroxylase deficiency (21OHD). When the nonclassical (mild) form is included, 21OHD is the most common genetic disease in human beings. With the advent of pharmaceutical preparation of glucocorticoids starting in the 1960s and newborn screening starting in the 1990s, the majority of children with 21OHD are reaching adulthood, which has yielded a cohort of patients with, in essence, a new disease. Only recently have some data emerged from cohorts of adults with 21OHD, and in some centers, experience with the management of these patients is growing. These patients suffer from poor health, infertility, characteristic tumors in the adrenal glands and gonads, and consequences of chronic glucocorticoid therapy. Their care is fragmented and inconsistent, and many stop taking their medications out of frustration. Internal medicine residents and endocrinology fellows receive little training in their care, which further discourages their seeking medical attention. Adults with 21OHD have a different physiology from patients with Addison's disease or other androgen excess states, and their needs are different than those of young children with 21OHD. Consequently, their care requires unorthodox treatment and monitoring strategies foreign to most endocrine practitioners. Our goal for this article is to review their physiology, complications, and needs in order to develop rational and effective treatment and monitoring strategies. PMID:23837188

Arlt, Wiebke

2013-01-01

388

Giant bilateral adrenal myelolipoma with congenital adrenal hyperplasia.  

PubMed

Myelolipomas are rare and benign neoplasms, predominant of the adrenal glands, consisting of adipose and mature hematopoietic tissue, commonly discovered incidentally with increased use of radiologic imaging. Few cases of giant bilateral adrenal masses are reported, especially in the setting of congenital adrenal hyperplasia (CAH). We report the case of a 39-year-old male with a history of CAH secondary to 21-? hydroxylase deficiency on steroids since childhood, self-discontinued during adolescence, presenting with abdominal distension, fatigue, decreased libido, and easy bruising. Imaging revealed giant bilateral adrenal masses. He subsequently underwent bilateral adrenalectomy found to be myelolipomas measuring 30 × 25 × 20?cm on the left and weighing 4.1?kg and 25 × 20 × 13?cm on the right and weighing 2.7?kg. Adrenal myelolipomas are found to coexist with many other conditions such as Cushing's syndrome, Addison's disease, and CAH. We discuss the association with high adrenocorticotropic hormone (ACTH) states and review the studies involving ACTH as proponent leading to myelolipomas. Massive growth of these tumors, as in our case, can produce compression and hemorrhagic symptoms. We believe it is possible that self-discontinuation of steroids, in the setting of CAH, may have resulted in the growth of his adrenal masses. PMID:25140269

Al-Bahri, S; Tariq, A; Lowentritt, B; Nasrallah, D V

2014-01-01

389

A classification system for conditions causing condylar hyperplasia.  

PubMed

A classification system was developed to place patients with condylar hyperplasia (CH) into categories based on histology, clinical and imaging characteristics, effects on the jaws and facial structures, and rate of occurrence. Four major categories were defined. CH type 1 is an accelerated and prolonged growth aberration of the "normal" mandibular condylar growth mechanism, causing a predominantly horizontal growth vector, resulting in prognathism that can occur bilaterally (CH type 1A) or unilaterally (CH type 1B). CH type 2 refers to enlargement of the mandibular condyle caused by an osteochondroma, resulting in predominantly unilateral vertical overgrowth and elongation of the mandible and face. One of the forms has predominantly a vertical growth vector and condylar enlargement, but without exophytic tumor extensions (type 2A), whereas the other primary form grows vertically but develops horizontal exophytic tumor growth off of the condyle (CH type 2B). CH type 3 includes other rare, benign tumors and CH type 4 includes malignant conditions that originate in the mandibular condyle causing enlargement. The order of classification is based on occurrence rates and type of pathology, where CH type 1A is the most commonly occurring form and CH type 4 is the rarest. This classification system for CH pathology should help the clinician understand the nature of the pathology, progression if untreated, recommended ages for surgical intervention to minimize adverse effects on subsequent facial growth and development in younger patients, and the surgical protocols to comprehensively and predictably treat these conditions. PMID:24388179

Wolford, Larry M; Movahed, Reza; Perez, Daniel E

2014-03-01

390

[Transurethral rotoresection - a new method of benign prostatic hyperplasia treatment].  

PubMed

Karl Storz company (Germany) offers a novel endoscopic technology in the treatment of benign prostatic hyperplasia (BPH) i.e. rotoresection which combined mechanic and electrosurgical methods of removal of the hyperplastic tissue. The operation is performed with application of a special rotoresectoscope connected with a rotor electrode which, in its turn, is connected with mechanical rotor generator making it to rotate and with powerful electrogenerator (radiotome). The hyperplastic tissue is removed both mechanically (by high-frequency rotation of the rotor tip) and due to electrovaporization with simultaneous coagulation of the underlying tissue layers. Transurethral rotoresection was performed in 40 patients with BPH. Intraoperative and postoperative complications were not observed. Examination at discharge and 1 month after surgery showed a 4-fold decrease in the prostatic symptoms by IPSS scale, residual urine decreased 3-fold, maximal urine flow rate rose 2.5-fold. Transurethral rotoresection combines effective removal of BPH tissue with minimal intraoperative bleeding. It is a good alternative to conventional TUR. For more detailed evaluation further studied are needed. PMID:11186699

Martov, A G; Merinov, D S; Aboian, I A; Pavlov, S V; Drozhzheva, V V

2000-01-01

391

Prostate brachytherapy in patients with median lobe hyperplasia.  

PubMed

Our aim was to document the technical and clinical course of prostate brachytherapy patients with radiographic evidence of median lobe hyperplasia (MLH). Eight patients with MLH were identified during our routine brachytherapy practice, representing 9% of the 87 brachytherapy patients treated during a 6-month period. No effort was made to avoid brachytherapy in patients noted to have MLH on diagnostic work-up. Cystoscopic evaluation was not routinely performed. Postimplant axial computed tomographic (CT) images of the prostate were obtained at 0.5 cm intervals. Preimplant urinary obstructive symptoms were quantified by the criteria of the American Urologic Association (AUA). Each patient was contacted during the writing of this report to update postimplant morbidity information. There was no apparent association between the degree of MLH and preimplant prostate volume or AUA score. Intraoperatively, we were able to visualize MLH by transrectal ultrasound and did not notice any particular difficulty placing sources in the MLH tissue or migration of sources out of the tissue. The prescription isodose covered from 81% to 99% of the postimplant CT-defined target volume, achieving adequate dose to the median lobe tissue in all patients. Two of the eight patients developed acute, postimplant urinary retention. The first patient required intermittent self-catheterization for 3 months and then resumed spontaneous urination. MLH does not appear to be a strong contraindication to prostate brachytherapy, and prophylactic resection of hypertrophic tissue in such patients is probably not warranted. Int. J. Cancer (Radiat. Oncol. Invest.) 90, 152-156 (2000). PMID:10900427

Wallner, K; Smathers, S; Sutlief, S; Corman, J; Ellis, W

2000-06-20

392

c-Kit signaling determines neointimal hyperplasia in arteriovenous fistulae.  

PubMed

Stenosis of arteriovenous (A-V) fistulae secondary to neointimal hyperplasia (NIH) compromises dialysis delivery, which worsens patients' quality of life and increases medical costs associated with the maintenance of vascular accesses. In the present study, we evaluated the role of the receptor tyrosine kinase c-Kit in A-V fistula neointima formation. Initially, c-Kit was found in the neointima and adventitia of human brachiobasilic fistulae, whereas it was barely detectable in control veins harvested at the time of access creation. Using the rat A-V fistula model to study venous vascular remodeling, we analyzed the spatial and temporal pattern of c-Kit expression in the fistula wall. Interestingly, c-Kit immunoreactivity increased with time after anastomosis, which concurred with the accumulation of cells in the venous intima. In addition, c-Kit expression in A-V fistulae was positively altered by chronic kidney failure conditions. Both blockade of c-Kit with imatinib mesylate (Gleevec) and inhibition of stem cell factor production with a specific short hairpin RNA prevented NIH in the outflow vein of experimental fistulae. In agreement with these data, impaired c-Kit activity compromised the development of NIH in A-V fistulae created in c-Kit(W/Wv) mutant mice. These results suggest that targeting of the c-Kit signaling pathway may be an effective approach to prevent postoperative NIH in A-V fistulae. PMID:25186298

Skartsis, Nikolaos; Martinez, Laisel; Duque, Juan Camilo; Tabbara, Marwan; Velazquez, Omaida C; Asif, Arif; Andreopoulos, Fotios; Salman, Loay H; Vazquez-Padron, Roberto I

2014-11-01

393

Restoration of anterior regeneration in a planarian with limited regenerative ability.  

PubMed

Variability of regenerative potential among animals has long perplexed biologists. On the basis of their exceptional regenerative abilities, planarians have become important models for understanding the molecular basis of regeneration. However, planarian species with limited regenerative abilities are also found. Despite the importance of understanding the differences between closely related, regenerating and non-regenerating organisms, few studies have focused on the evolutionary loss of regeneration, and the molecular mechanisms leading to such regenerative loss remain obscure. Here we examine Procotyla fluviatilis, a planarian with restricted ability to replace missing tissues, using next-generation sequencing to define the gene expression programs active in regeneration-permissive and regeneration-deficient tissues. We found that Wnt signalling is aberrantly activated in regeneration-deficient tissues. Notably, downregulation of canonical Wnt signalling in regeneration-deficient regions restores regenerative abilities: blastemas form and new heads regenerate in tissues that normally never regenerate. This work reveals that manipulating a single signalling pathway can reverse the evolutionary loss of regenerative potential. PMID:23883929

Sikes, James M; Newmark, Phillip A

2013-08-01

394

Testing a Regenerative Carbon Dioxide and Moisture Removal Technology  

NASA Astrophysics Data System (ADS)

The National Aeronautics and Space Administration supported the development of a new vacuum-desorbed regenerative carbon dioxide and humidity control technology for use in short duration human spacecraft. The technology was baselined for use in the Orion Crew Exploration Vehicle's Environmental Control and Life Support System (ECLSS). Termed the Carbon Diox-ide And Moisture Removal Amine Swing-bed (CAMRAS), the unit was developed by Hamilton Sundstrand and has undergone extensive testing at Johnson Space Center. The tests were per-formed to evaluate performance characteristics under range of operating conditions and human loads expected in future spacecraft applications, as part of maturation to increase its readiness for flight. Early tests, conducted at nominal atmospheric pressure, used human metabolic sim-ulators to generate loads, with later tests making us of human test subjects. During these tests many different test cases were performed, involving from 1 to 6 test subjects, with different activity profiles (sleep, nominal and exercise). These tests were conducted within the airlock portion of a human rated test chamber sized to simulate the Orion cabin free air volume. More recently, a test was completed that integrated the CAMRAS with a simulated suit loop using prototype umbilicals and was conducted at reduced atmospheric pressure and elevated oxygen levels. This paper will describe the facilities and procedures used to conduct these and future tests, and provide a summary of findings.

Barta, Daniel J.; Button, Amy; Sweterlitsch, Jeffrey; Curley, Suzanne

395

Cord blood in regenerative medicine: do we need immune suppression?  

PubMed Central

Cord blood is currently used as an alternative to bone marrow as a source of stem cells for hematopoietic reconstitution after ablation. It is also under intense preclinical investigation for a variety of indications ranging from stroke, to limb ischemia, to myocardial regeneration. A major drawback in the current use of cord blood is that substantial morbidity and mortality are associated with pre-transplant ablation of the recipient hematopoietic system. Here we raise the possibility that due to unique immunological properties of both the stem cell and non-stem cell components of cord blood, it may be possible to utilize allogeneic cells for regenerative applications without needing to fully compromise the recipient immune system. Issues raised will include: graft versus host potential, the immunogeneicity of the cord blood graft, and the parallels between cord blood transplantation and fetal to maternal trafficking. The previous use of unmatched cord blood in absence of any immune ablation, as well as potential steps for widespread clinical implementation of allogeneic cord blood grafts will also be discussed. PMID:17261200

Riordan, Neil H; Chan, Kyle; Marleau, Annette M; Ichim, Thomas E

2007-01-01

396

Thermal Inkjet Printing in Tissue Engineering and Regenerative Medicine  

PubMed Central

With the advantages of high throughput, digital control, and highly accurate placement of cells and biomaterial scaffold to the desired 2D and 3D locations, bioprinting has great potential to develop promising approaches in translational medicine and organ replacement. The most recent advances in organ and tissue bioprinting based on the thermal inkjet printing technology are described in this review. Bioprinting has no or little side effect to the printed mammalian cells and it can conveniently combine with gene transfection or drug delivery to the ejected living systems during the precise placement for tissue construction. With layer-by-layer assembly, 3D tissues with complex structures can be printed using scanned CT or MRI images. Vascular or nerve systems can be enabled simultaneously during the organ construction with digital control. Therefore, bioprinting is the only solution to solve this critical issue in thick and complex tissues fabrication with vascular system. Collectively, bioprinting based on thermal inkjet has great potential and broad applications in tissue engineering and regenerative medicine. This review article introduces some important patents related to bioprinting living systems and the bioprinting in tissue engineering field. PMID:22436025

Cui, Xiaofeng; Boland, Thomas; D'Lima, Darryl D.; Lotz, Martin K.

2013-01-01

397

The Mouse Median Nerve Experimental Model in Regenerative Research  

PubMed Central

Sciatic nerve crush injury in rat animal model is one of the most common experimental models used in regenerative research. However, the availability of transgenic mouse for nerve regeneration studies is constantly increasing and, therefore, the shift from rat model to mouse model is, in some cases, necessary. Moreover, since most of the human nerve lesions occur in the upper limb, it is also advantageous to shift from sciatic nerve to median nerve. In this study we described an experimental model which involves lesions of the median nerve in the mouse. Data showed that the finger flexor muscle contraction strength, assessed to evaluate the motor function recovery, and reached values not different from the control already 20 days after injury. The degree of nerve regeneration evaluated with stereological methods in light microscopy showed that, 25 days after injury, the number of regenerated myelinated fibers was comparable to the control, but they were smaller with a thinner myelin thickness. Stereological analysis made in electron microscopy confirmed these results, although the total number of fibers quantified was significantly higher compared to light microscopy analysis, due to the very small size of some fibers that can be detected only in electron microscopy.

Buskbjerg Jager, Sara

2014-01-01

398

Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine  

PubMed Central

Mesenchymal stem cells (MSCs) are partially defined by their ability to differentiate into tissues including bone, cartilage and adipose in vitro, but it is their trophic, paracrine and immunomodulatory functions that may have the greatest therapeutic impact in vivo. Unlike pharmaceutical treatments that deliver a single agent at a specific dose, MSCs are site regulated and secrete bioactive factors and signals at variable concentrations in response to local microenvironmental cues. Significant progress has been made in understanding the biochemical and metabolic mechanisms and feedback associated with MSC response. The anti-inflammatory and immunomodulatory capacity of MSC may be paramount in the restoration of localized or systemic conditions for normal healing and tissue regeneration. Allogeneic MSC treatments, categorized as a drug by regulatory agencies, have been widely pursued, but new studies demonstrate the efficacy of autologous MSC therapies, even for individuals affected by a disease state. Safety and regulatory concerns surrounding allogeneic cell preparations make autologous and minimally manipulated cell therapies an attractive option for many regenerative, anti-inflammatory and autoimmune applications. PMID:24232253

Murphy, Matthew B; Moncivais, Kathryn; Caplan, Arnold I

2013-01-01

399

Regenerative gas turbine with thermal-energy conservation  

SciTech Connect

A thermal-energy conservation system for a regenerative gas turbine, and preferably a highly-regenerated high-temperature two-shaft gas-turbine engine, operating at an equilibrium temperature is provided. The gas-turbine engine includes a compressor, a combustor, a fuel throttle, a turbine, and a regenerator which transfers thermal energy from the heated exhaust gases of the turbine to the compressed air delivered to the combustor. A compressor air-inlet throttle is operatively associated with the fuel throttle so that the flow of air to the compressor is reduced to a predetermined level when the fuel throttle is moved from a high power position to a low power or negative power position. This reduced air flow to the compressor causes a corresponding reduced flow of gases to the turbine and results in engine braking. With the heat added by engine braking, the thermal energy of the gas-turbine engine and particularly of the regenerator is substantially maintained and conserved at the equilibrium temperature with minimum cooling. In a preferred embodiment, the compressor air-inlet throttle is constituted by the guide vanes of the compressor.

Best, G.C.

1982-06-17

400

Polymer-based microparticles in tissue engineering and regenerative medicine.  

PubMed

Different types of biomaterials, processed into different shapes, have been proposed as temporary support for cells in tissue engineering (TE) strategies. The manufacturing methods used in the production of particles in drug delivery strategies have been adapted for the development of microparticles in the fields of TE and regenerative medicine (RM). Microparticles have been applied as building blocks and matrices for the delivery of soluble factors, aiming for the construction of TE scaffolds, either by fusion giving rise to porous scaffolds or as injectable systems for in situ scaffold formation, avoiding complicated surgery procedures. More recently, organ printing strategies have been developed by the fusion of hydrogel particles with encapsulated cells, aiming the production of organs in in vitro conditions. Mesoscale self-assembly of hydrogel microblocks and the use of leachable particles in three-dimensional (3D) layer-by-layer (LbL) techniques have been suggested as well in recent works. Along with innovative applications, new perspectives are open for the use of these versatile structures, and different directions can still be followed to use all the potential that such systems can bring. This review focuses on polymeric microparticle processing techniques and overviews several examples and general concepts related to the use of these systems in TE and RE applications. The use of materials in the development of microparticles from research to clinical applications is also discussed. PMID:21584949

Oliveira, Mariana B; Mano, João F

2011-07-01

401

Refurbishment of one-person regenerative air revitalization system  

NASA Technical Reports Server (NTRS)

Regenerative processes for the revitalization of spacecraft atmospheres and reclamation of waste waters are essential for making long-term manned space missions a reality. Processes studied include: static feed water electrolysis for oxygen generation, Bosch carbon dioxide reduction, electrochemical carbon dioxide concentration, vapor compression distillation water recovery, and iodine monitoring. The objectives were to: provide engineering support to Marshall Space Flight Center personnel throughout all phases of the test program, e.g., planning through data analysis; fabricate, test, and deliver to Marshall Space Flight Center an electrochemical carbon dioxide module and test stand; fabricate and deliver an iodine monitor; evaluate the electrochemical carbon dioxide concentrator subsystem configuration and its ability to ensure safe utilization of hydrogen gas; evaluate techniques for recovering oxygen from a product oxygen and carbon dioxide stream; and evaluate the performance of an electrochemical carbon dioxide concentrator module to operate without hydrogen as a method of safe haven operation. Each of the tasks were related in that all focused on providing a better understanding of the function, operation, and performance of developmental pieces of environmental control and life support system hardware.

Powell, Ferolyn T.

1989-01-01

402

Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Biology  

NASA Astrophysics Data System (ADS)

The potential of human embryonic stem cells (ESCs) for regenerative medicine is unquestionable, but practical and ethical considerations have hampered clinical application and research. In an attempt to overcome these issues, the conversion of somatic cells into pluripotent stem cells similar to ESCs, commonly termed nuclear reprogramming, has been a top objective of contemporary biology. More than 40 years ago, King, Briggs, and Gurdon pioneered somatic cell nuclear reprogramming in frogs, and in 1981 Evans successfully isolated mouse ESCs. In 1997 Wilmut and collaborators produced the first cloned mammal using nuclear transfer, and then Thomson obtained human ESCs from in vitro fertilized blastocysts in 1998. Over the last 2 decades we have also seen remarkable findings regarding how ESC behavior is controlled, the importance of which should not be underestimated. This knowledge allowed the laboratory of Shinya Yamanaka to overcome brilliantly conceptual and technical barriers in 2006 and generate induced pluripotent stem cells (iPSCs) from mouse fibroblasts by overexpressing defined combinations of ESC-enriched transcription factors. Here, we discuss some important implications of human iPSCs for biology and medicine and also point to possible future directions.

Pei, Duanqing; Xu, Jianyong; Zhuang, Qiang; Tse, Hung-Fat; Esteban, Miguel A.

403

Stem cell-based composite tissue constructs for regenerative medicine.  

PubMed

A major task of contemporary medicine and dentistry is restoration of human tissues and organs lost to diseases and trauma. A decade-long intense effort in tissue engineering has provided the proof of concept for cell-based replacement of a number of individual tissues such as the skin, cartilage, and bone. Recent work in stem cell-based in vivo restoration of multiple tissue phenotypes by composite tissue constructs such as osteochondral and fibro-osseous grafts has demonstrated probable clues for bioengineered replacement of complex anatomical structures consisting of multiple cell lineages such as the synovial joint condyle, tendon-bone complex, bone-ligament junction, and the periodontium. Of greater significance is a tangible contribution by current attempts to restore the structure and function of multitissue structures using cell-based composite tissue constructs to the understanding of ultimate biological restoration of complex organs such as the kidney or liver. The present review focuses on recent advances in stem cell-based composite tissue constructs and attempts to outline challenges for the manipulation of stem cells in tailored biomaterials in alignment with approaches potentially utilizable in regenerative medicine of human tissues and organs. PMID:15929124

Rahaman, Mohamed N; Mao, Jeremy J

2005-08-01

404

Potency of Fish Collagen as a Scaffold for Regenerative Medicine  

PubMed Central

Cells, growth factors, and scaffold are the crucial factors for tissue engineering. Recently, scaffolds consisting of natural polymers, such as collagen and gelatin, bioabsorbable synthetic polymers, such as polylactic acid and polyglycolic acid, and inorganic materials, such as hydroxyapatite, as well as composite materials have been rapidly developed. In particular, collagen is the most promising material for tissue engineering due to its biocompatibility and biodegradability. Collagen contains specific cell adhesion domains, including the arginine-glycine-aspartic acid (RGD) motif. After the integrin receptor on the cell surface binds to the RGD motif on the collagen molecule, cell adhesion is actively induced. This interaction contributes to the promotion of cell growth and differentiation and the regulation of various cell functions. However, it is difficult to use a pure collagen scaffold as a tissue engineering material due to its low mechanical strength. In order to make up for this disadvantage, collagen scaffolds are often modified using a cross-linker, such as gamma irradiation and carbodiimide. Taking into account the possibility of zoonosis, a variety of recent reports have been documented using fish collagen scaffolds. We herein review the potency of fish collagen scaffolds as well as associated problems to be addressed for use in regenerative medicine. PMID:24982861

Yamamoto, Kohei; Yanagiguchi, Kajiro

2014-01-01

405

Lymphoid Nodular Hyperplasia of the Terminal Ileum Can Mimic Active Crohn Disease on MR Enterography.  

PubMed

OBJECTIVE. The purpose of this article is to describe the MRI findings associated with lymphoid nodular hyperplasia at MR enterography and test the ability of radiologists to differentiate healthy control subjects from patients with Crohn disease (CD). MATERIALS AND METHODS. Ethical approval was granted for this retrospective study. Thirty-five subjects (nine with lymphoid nodular hyperplasia, 13 with CD, and 13 control subjects) who had undergone MR enterography and ileocolonoscopy were identified from the hospital database. Two abdominal radiologists, working in consensus and blinded to diagnosis, scored enteric MR images for T2 signal, contrast enhancement, mural thickness, and diffusion-weighted imaging (DWI) signal and measured the apparent diffusion coefficient (ADC) in all three groups. Scores were compared using the Kruskal-Wallis test. RESULTS. T2 signal and contrast enhancement were judged subjectively to be greater in patients with lymphoid nodular hyperplasia and CD than control subjects (p < 0.001). Mural thickness was greater for patients with lymphoid nodular hyperplasia (median, 6.0 mm) and CD (median, 7.3 mm) than control subjects (median, 2.3 mm) (p < 0.001). Lymphoid nodular hyperplasia and CD increased subjective DWI signal and reduced ADC in comparison with normal control subjects; median ADC was 1.34 × 10(-3) mm(2)/s for lymphoid nodular hyperplasia, 1.36 × 10(-3) mm(2)/s for CD, and 1.86 × 10(-3) mm(2)/s for control subjects (p < 0.001). None of T2 signal, contrast enhancement, wall thickness, DWI signal, or ADC value significantly differed between lymphoid nodular hyperplasia and CD. Lymphoid nodular hyperplasia was erroneously diagnosed as CD in blinded assessment in four of nine cases (44%), whereas all cases of CD and healthy control subjects were correctly classified. CONCLUSION. Lymphoid nodular hyperplasia alters both subjective and quantitative MRI parameters, including T2 signal, contrast enhancement, mural thickness, and ADC. In a subset of patients, lymphoid nodular hyperplasia may be indistinguishable from CD on MR enterography. PMID:25247969

Plumb, Andrew A; Pendsé, Douglas A; McCartney, Sara; Punwani, Shonit; Halligan, Steve; Taylor, Stuart A

2014-10-01

406

Focal nodular hyperplasia of the liver: an unusual association with diabetes mellitus in a child and review of literature  

PubMed Central

Hepatic hemangioma, adenoma and focal nodular hyperplasia are the most frequent benign lesions of the liver, but they are all infrequent among pediatric population. The reports of focal nodular hyperplasia in children have recently increased in number, with many cases associated to drug intake, particularly to chemotherapy. We here describe, to our knowledge, the first case of focal nodular hyperplasia in association with diabetes mellitus in childhood. PMID:20504362

2010-01-01

407

Focal nodular hyperplasia of the liver: an unusual association with diabetes mellitus in a child and review of literature.  

PubMed

Hepatic hemangioma, adenoma and focal nodular hyperplasia are the most frequent benign lesions of the liver, but they are all infrequent among pediatric population. The reports of focal nodular hyperplasia in children have recently increased in number, with many cases associated to drug intake, particularly to chemotherapy. We here describe, to our knowledge, the first case of focal nodular hyperplasia in association with diabetes mellitus in childhood. PMID:20504362

Farruggia, Piero; Alaggio, Rita; Cardella, Francesca; Tropia, Serena; Trizzino, Antonino; Ferrara, Francesca; D'Angelo, Paolo

2010-01-01

408

Natural gas pyrolysis in the regenerative gas heaterPart i: Natural gas thermal decomposition at a hot matrix in a regenerative gas heater  

Microsoft Academic Search

This paper presents the results of an experimental investigation of natural gas pyrolysis at a hot matrix in a high temperature regenerative gas heater. It was demonstrated that formation of pyrocarbon during thermal decomposition of natural gas significantly influences upon the process efficiency. Burn out of the carbon deposits from the matrix during the matrix heating up stage produces components

R. G Popov; E. E Shprilrain; V. M Zaytchenko

1999-01-01

409

Natural gas pyrolysis in the regenerative gas heater Part ii: Natural gas pyrolysis in the free volume of the regenerative gas heater  

Microsoft Academic Search

This paper discusses the results of an experimental study of a new method of natural gas pyrolysis based on thermal decomposition in a flow of high temperature carrier gas preliminary heated in the regenerative heater matrix. It has been shown that in this case the methane carbon is almost completely converted into black carbon and no pyrocarbon is produced in

R. G Popov; E. E Shpilrain; V. M Zaytchenko

1999-01-01

410

Photoselective Vaporization for the Treatment of Benign Prostatic Hyperplasia  

PubMed Central

Background As an alternative to transurethral resection of the prostate (TURP), photoselective vaporization of the prostate (PVP) provides a bloodless, relatively painless relief of lower urinary tract symptoms for men with benign prostatic hyperplasia. Following a review of the evidence in 2006, the Ontario Health Technology Advisory Committee recommended that a study be conducted to evaluate PVP in Ontario. Objectives To compare the clinical effectiveness, safety, cost-effectiveness, and budget impact of PVP compared to conventional TURP for the treatment of benign prostatic hyperplasia in Ontario. Methods A prospective, nonrandomized trial was conducted in 3 Ontario centres. Consenting subjects were assessed at baseline and 1, 3, and 6 months following surgery. Outcome measures included International Prostate Symptom Score (IPSS), peak urinary flow rate (Qmax), post-void residual (PVR) volume, prostate-specific antigen (PSA), health-related quality of life (HRQOL) using the EuroQol 5 Domain questionnaire, and the Sexual Health Inventory for Men (SHIM) score. Adverse events, resource utilization, and productivity losses were also assessed. Cost-effectiveness and budget impact analyses were completed using data from the study. Results Between February 2008 and August 2010, 164 subjects were enrolled in the study (n = 140 for PVP and n = 24 for TURP). Treatment outcomes were similar between the 2 groups at 6 months, with the IPSS decreasing similarly over time (P = 0.718). For other treatment outcomes (Qmax, PSA, HRQOL, SHIM) both treatments provided similar benefit over time; only changes in PVR volume favoured PVP (P = 0.018). The majority of PVP patients were managed on an outpatient basis, with only 7.1% requiring admission (all TURP subjects were inpatients). At 6 months, PVP was less costly than TURP ($3,891 versus $4,863; P = 0.001), with similar quality-adjusted life-years (0.448 versus 0.441; P = 0.658). PVP remained the most cost-effective treatment across all decision-making thresholds, with the technology costing less and providing similar clinical outcomes. Extrapolating the results to a provincial level indicated (based on an estimated case volume of 12,335 TURPs) that there is an opportunity to reallocate just over $14 million (Cdn), primarily related to the reduced need for hospital admission. Limitations This study was nonrandomized, and the results should be interpreted with some caution, despite generally similar baseline characteristics between the 2 groups. Recruiting individuals to the TURP arm was a challenge, resulting in a size imbalance between treatment arms. Conclusions Based on this analysis, PVP appears to be a cost-effective alternative to TURP, providing similar clinical benefit at a lower cost to the health system. Plain Language Summary For men with lower urinary tract symptoms due to an enlarged prostate, a laser treatment called photoselective vaporization of the prostate (or PVP) is just as effective as surgery. PVP does not require an overnight stay in the hospital for most men, and it costs almost $1,000 less. This report describes the results of a study that collected information about treatment outcomes, quality of life, and health care use related to PVP and surgery in Ontario. PMID:24019857

Bowen, James M.; Whelan, J. Paul; Hopkins, Robert B.; Burke, Natasha; Woods, Edward A.; McIsaac, Gary P.; O'Reilly, Daria J.; Xie, Feng; Sehatzadeh, Shayan; Levin, Leslie; Mathew, Suja P.; Patterson, Lisa L.; Goeree, Ron; Tarride, Jean-Eric

2013-01-01

411

Mortality from benign prostatic hyperplasia: worldwide trends 1950-92.  

PubMed Central

STUDY OBJECTIVE--To provide a systematic overview of worldwide trends in mortality from benign prostatic hyperplasia (BPH) over the past four decades. DESIGN--This was a descriptive analysis based on age adjusted mortality rates for BPH between 1950 and 1992 for 41 countries from five continents. SETTING--Official death certifications from the World Health Organization database. MAIN RESULTS--In the 1950s, the highest age adjusted (on the world standard population) mortality rates for BPH in Europe were in Denmark (22.8/100,000) and Germany (18.1), followed by Scandinavian countries, the UK, and Switzerland. Italy had rates around 10/100,000, and rates were lower in eastern and southern Europe (5-8/100,000). Between 1950 and 1990, a fall of over 90%, or even 95%, was observed in most western European countries. Thus, in the early 1980s, overall mortality from BPH ranged between 0.5 and 1.5/100,000 in most western European countries. In proportional terms, similar reductions were registered in other developed countries of North America, Asia (that is, Japan or Singapore), and Oceania. A fall in rates was also observed in eastern Europe and in Latin America, particularly from the late 1970s onwards, although these reductions were generally much smaller. Thus, in the early 1990s, most countries in these areas had BPH rates between 1 and 5/100,000. The pattern of trends was, at least qualitatively, similar at younger ages, although most falls were proportionally greater. CONCLUSIONS--The most probable interpretation of these trends is that therapeutic improvements--including more widespread and timely surgery, introduction of less invasive techniques, such as transurethral prostatectomy, and possibly the development of medical treatments--have had a favourable and substantial impact on BPH mortality. There are, however, areas of the world, including several countries of western Europe and South America, where rates are still very high. PMID:7544392

La Vecchia, C; Levi, F; Lucchini, F

1995-01-01

412

Laser Treatment of Benign Prostatic Hyperplasia: Dosimetric and Thermodynamic Considerations  

NASA Astrophysics Data System (ADS)

Benign prostatic hyperplasia (BPH) is the most commonly occurring neoplastic disease in the aging human male. Currently, surgical treatment of BPH is the primary therapeutic method. However, due to surgical complications, less invasive methods of treatment are desirable. In recent years, thermal coagulation of the hyperplastic prostate by a laser has received a considerable amount of attention. Nevertheless, the optimum laser irradiation parameters that lead to a successful and safe treatment of BPH have not been determined. This dissertation studies the physics of laser coagulation of prostate from both basic science and practical perspectives. Optical properties of prostatic tissue are determined over a spectrum of wavelengths. Knowledge of these properties allows for selection of appropriate laser wavelengths and provides a basis for performing dose equivalency studies among various types of lasers. Furthermore, knowledge of optical properties are needed for development of computer simulation models that predict the extent of thermal injury during laser irradiation of prostate. A computer model of transurethral heating of prostate that can be used to guide the clinical studies in determining an optimum dosimetry is then presented. Studies of the effects of non-laser heating devices, optical properties, blood perfusion, surface irrigation, and beam geometry are performed to examine the extent of heat propagation within the prostate. An in vitro model for transurethral laser irradiation of prostate is also presented to examine the effects of an 810 nm diode laser, thermal boundary conditions, and energy deposition rate during Nd:YAG laser irradiation. Results of these studies suggest that in the presence of laminar irrigation, the convective boundary condition is dominated by thermal diffusion as opposed to the bulk motion of the irrigation fluid. Distinct phases of thermal events are also identified during the laser irradiation. The in vivo studies of transurethral laser irradiation of prostate in canine models are also performed to search for an optimum dosimetry that will result in a maximum zone of coagulation necrosis.

Anvari, Bahman

1993-01-01

413

Cryogenic reactant storage for lunar base regenerative fuel cells  

NASA Technical Reports Server (NTRS)

There are major advantages to be gained by integrating a cryogenic reactant storage system with a hydrogen-oxygen regenerative fuel cell (RFC) to provide on-site electrical power during the lunar night. Although applicable to any power system using hydrogen-oxygen RFC's for energy storage, cryogenic reactant storage offers a significant benefit whenever the sun/shade cycle and energy storage period approach hundreds of hours. For solar power installations on the moon, cryogenic reactant storage reduces overall specific mass and meteoroid vulnerability of the system. In addition, it offers synergistic benefits to on-site users, such as availability of primary fuel cell reactants for surface rover vehicles and cryogenic propellants for OTV's. The integration involves processing and storing the RFC reactant streams as cryogenic liquids rather than pressurized gases, so that reactant containment (tankage per unit mass of reactants) can be greatly reduced. Hydrogen-oxygen alkaline RFC's, GaAs photovoltaic (PV) arrays, and space cryogenic processing/refrigeration technologies are assumed to be available for the conceptual system design. Advantages are demonstrated by comparing the characteristics of two power system concepts: a conventional lunar surface PV/RFC power system using pressurized gas storage in SOA filament wound pressure vessels and, that same system with gas liquefaction and storage replacing the pressurized storage. Comparisons are made at 20 and 250 kWe. Although cryogenic storage adds a processing plant (drying and liquefaction) to the system plus 30 percent more solar array to provide processing power, the approximate order of magnitude reduction in tankage mass, confirmed by this analysis, results in a reduction in overall total system mass of approximately 50 percent.

Kohout, Lisa L.

1989-01-01

414

Regenerative therapies for equine degenerative joint disease: a preliminary study.  

PubMed

Degenerative joint disease (DJD) is a major cause of reduced athletic function and retirement in equine performers. For this reason, regenerative therapies for DJD have gained increasing interest. Platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) were isolated from a 6-year-old donor horse. MSCs were either used in their native state or after chondrogenic induction. In an initial study, 20 horses with naturally occurring DJD in the fetlock joint were divided in 4 groups and injected with the following: 1) PRP; 2) MSCs; 3) MSCs and PRP; or 4) chondrogenic induced MSCs and PRP. The horses were then evaluated by means of a clinical scoring system after 6 weeks (T1), 12 weeks (T2), 6 months (T3) and 12 months (T4) post injection. In a second study, 30 horses with the same medical background were randomly assigned to one of the two combination therapies and evaluated at T1. The protein expression profile of native MSCs was found to be negative for major histocompatibility (MHC) II and p63, low in MHC I and positive for Ki67, collagen type II (Col II) and Vimentin. Chondrogenic induction resulted in increased mRNA expression of aggrecan, Col II and cartilage oligomeric matrix protein (COMP) as well as in increased protein expression of p63 and glycosaminoglycan, but in decreased protein expression of Ki67. The combined use of PRP and MSCs significantly improved the functionality and sustainability of damaged joints from 6 weeks until 12 months after treatment, compared to PRP treatment alone. The highest short-term clinical evolution scores were obtained with chondrogenic induced MSCs and PRP. This study reports successful in vitro chondrogenic induction of equine MSCs. In vivo application of (induced) MSCs together with PRP in horses suffering from DJD in the fetlock joint resulted in a significant clinical improvement until 12 months after treatment. PMID:24465787

Broeckx, Sarah; Zimmerman, Marieke; Crocetti, Sara; Suls, Marc; Mariën, Tom; Ferguson, Stephen J; Chiers, Koen; Duchateau, Luc; Franco-Obregón, Alfredo; Wuertz, Karin; Spaas, Jan H

2014-01-01

415

A Whole-Organ Regenerative Medicine Approach for Liver Replacement  

PubMed Central

Background & Aims The therapy of choice for end-stage liver disease is whole-organ liver transplantation, but this option is limited by a shortage of donor organs. Cell-based therapies and hepatic tissue engineering have been considered as alternatives to liver transplantation, but neither has proven effective to date. A regenerative medicine approach for liver replacement has recently been described that includes the use of a three-dimensional organ scaffold prepared by decellularization of xenogeneic liver. The present study investigates a new, minimally disruptive method for whole-organ liver decellularization and three different cell reseeding strategies to engineer functional liver tissue. Methods A combination of enzymatic, detergent, and mechanical methods are used to remove all cells from isolated rat livers. Whole-organ perfusion is used in a customized organ chamber and the decellularized livers are examined by morphologic, biochemical, and immunolabeling techniques for preservation of the native matrix architecture and composition. Three different methods for hepatocyte seeding of the resultant three-dimensional liver scaffolds are evaluated to maximize cell survival and function: (1) direct parenchymal injection, (2) multistep infusion, or (3) continuous perfusion. Results The decellularization process preserves the three-dimensional macrostructure, the ultrastructure, the composition of the extracellular matrix components, the native microvascular network of the liver, and the bile drainage system, and up to 50% of growth factor content. The three-dimensional liver matrix reseeded with the multistep infusion of hepatocytes generated ?90% of cell engraftment and supported liver-specific functional capacities of the engrafted cells, including albumin production, urea metabolism, and cytochrome P450 induction. Conclusions Whole-organ liver decellularization is possible with maintenance of structure and composition suitable to support functional hepatocytes. PMID:21375407

Zhang, Li; Medberry, Chris; Fukumitsu, Ken; Faulk, Denver; Jiang, Hongbin; Reing, Janet; Gramignoli, Roberto; Komori, Junji; Ross, Mark; Nagaya, Masaki; Lagasse, Eric; Stolz, Donna; Strom, Stephen C.; Fox, Ira J.

2011-01-01

416

A regenerative multiple zone model for HCCI combustion  

SciTech Connect

A new conserved scalar approach, the so-called regenerative multiple zone (RMZ) model, is introduced to simulate combustion in homogeneous charge compression ignition (HCCI) engines with significant products of combustion. In this approach, two conserved scalars are introduced, the mixture fraction Z and the initial exhaust gas fraction J, to determine uniquely the state of the reactive system as a function of the two conserved scalars and time. For the numerical solution of the HCCI combustion, the conserved scalar plane is divided into different zones, which represent homogeneous reactors with constant initial exhaust gas level. Particularly, the zones are created based on the distribution of the initial exhaust gases and are mixed and regenerated at every time step during combustion in order to account for the history effects which are due to the finite rate chemistry. A proper methodology to create and initialize the new zones during the combustion, the so-called zone creation strategy (ZCS), is also proposed. For validation, the RMZ model is implemented in the 2DRD code, which is a computational fluid dynamics code that solves the governing equations for a two-dimensional reaction-diffusion problem. Initially, the consistency of the new model is validated in a one-dimensional reaction-diffusion (RD) case. Subsequently, the necessity for a proper zone creation strategy is demonstrated by a two-dimensional RD case. Next, a parametric study is performed to investigate the sensitivity of the new model on the maximum number of zones that is used. Finally, the limitations as well as the advantages of the RMZ model are discussed. (author)

Hamosfakidis, Vasileios; Im, Hong G.; Assanis, Dennis N. [Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109 (United States)

2009-04-15

417

Liability versus innovation: the legal case for regenerative medicine.  

PubMed

Medical innovation occupies a position somewhere between standard practice and clinical research, but innovation is primarily intended to benefit an individual patient where standard treatment fails. Medical innovations in the area of regenerative medicine have the potential to completely transform medical practice, but rely upon some major revision to the nature of treatments beyond drug-based therapies. There is considerable investment in scientific and clinical research, but further attention could be paid to legal barriers to medical innovation imposed by the threat of medical malpractice. We survey in this article the legal framework for making determinations of medical malpractice in general, and highlight the issues specific to innovative treatments. In essence, liability could be imposed for failing to adequately inform the patient about the innovative nature of the suggested therapy or based on the fact that the risks outweighed the benefits. As for the latter, we examine whether liability is likely to be based merely on deviating from existing practice or on an examination on the merits of the treatments' risks and benefits. The facts that some risks are unforeseeable and some benefits are external to the patient complicate negligence determinations. The first fact relates to the problem of judging adverse events in hindsight; the second, to the obligation to make decisions based on the patient's best interest and avoid conflict of interests. In addition, we evaluate the relationship between the obligations to secure the patient's informed consent and to avoid clinical negligence. We identify the need for further research to examine the significance of the putative anti-innovation bias that current liability regimen has, and to examine whether a move to strict liability might avoid such bias, while being fair to patients who contribute for the advancement of medical knowledge by participating in innovative therapies. PMID:24943515

Keren-Paz, Tsachi; El Haj, Alicia J

2014-10-01

418

Substrates coated with silver nanoparticles as a neuronal regenerative material.  

PubMed

Much effort has been devoted to the design of effective biomaterials for nerve regeneration. Here, we report the novel use of silver nanoparticles (AgNPs) as regenerative agents to promote neuronal growth. We grew neuroblastoma cells on surfaces coated with AgNPs and studied the effect on the development of the neurites during the initiation and the elongation growth phases. We find that the AgNPs function as favorable anchoring sites, and the growth on the AgNP-coated substrates leads to a significantly enhanced neurite outgrowth. Cells grown on substrates coated with AgNPs have initiated three times more neurites than cells grown on uncoated substrates, and two times more than cells grown on substrates sputtered with a plain homogenous layer of silver. The growth of neurites on AgNPs in the elongation phase was enhanced as well. A comparison with substrates coated with gold nanoparticles (AuNPs) and zinc oxide nanoparticles (ZnONPs) demonstrated a clear silver material-driven promoting effect, in addition to the nanotopography. The growth on substrates coated with AgNPs has led to a significantly higher number of initiating neurites when compared to substrates coated with AuNPs or ZnONPs. All nanoparticle-coated substrates affected and promoted the elongation of neurites, with a significant positive maximal effect for the AgNPs. Our results, combined with the well-known antibacterial effect of AgNPs, suggest the use of AgNPs as an attractive nanomaterial - with dual activity - for neuronal repair studies. PMID:24872701

Alon, Noa; Miroshnikov, Yana; Perkas, Nina; Nissan, Ifat; Gedanken, Aharon; Shefi, Orit

2014-01-01

419

Gastric hyperplasia and parietal cell loss in Taenia taeniaeformis inoculated immunodeficient mice.  

PubMed

Immunodeficient mice were studied to determine their suitability as models in investigating the role of Taenia taeniaeformis larval products in the development of gastric hyperplasia. Recombinant active gene 2 (RAG2)-deficient and severe combined immune-deficient (SCID) mice were studied as candidate animal models. RAG2-deficient mice inoculated orally with T. taeniaeformis eggs developed gastric hyperplasia with alcian blue-periodic acid-Schiff-positive cell proliferation similar to those of rats. SCID mice inoculated with different doses and routes of T. taeniaeformis in vitro-hatched oncospheres and those orally inoculated with eggs resulted also in different degrees of gastric hyperplasia. Influence of inoculation forms of parasite, doses and routes of inoculation on initiation of hyperplastic gastropathy was suggested to be dependent on number and size of developed larvae. Both RAG2-deficient and SCID mice with hyperplastic mucosa were observed with significant loss of parietal cells. Apparent decrease in parietal cell number was observed in SCID mice at 2 weeks after intraperitoneal inoculation with oncospheres before hyperplastic lesions developed. Earliest occurrence of gastric hyperplasia in SCID mice was observed at 3 weeks after oral inoculation of in vitro-hatched oncospheres, sooner than orally inoculated rats. The results suggested that these immunodeficient mice could be used as animal models to study factors involved in T. taeniaeformis-induced gastric mucous cell hyperplasia. PMID:11880230

Lagapa, Jose Trinipil; Konno, Kenjiro; Oku, Yuzaburo; Nonaka, Nariaki; Ito, Mamoru; Kamiya, Masao

2002-03-01

420

Adenomatoid hyperplasia of the minor salivary glands on the buccal mucosa: A rare case report  

PubMed Central

INTRODUCTION Adenomatoid hyperplasia of the minor salivary glands is a hyperplastic oral lesion which may be seen on minor salivary gland bearing areas on all oral mucosa, especially on soft and hard palate. This study reports a rare case of buccal adenomatoid hyperplasia of the minor salivary glands and discusses the clinical significance. PRESENTATION OF CASE 48 year old male patient presented with a complaint of a swelling on his left cheek. Clinical examination revealed a bluish mass on the buccal mucosa. A provisional diagnosis of salivary gland neoplasm was made and the lesion was excised under local anesthesia. The histological diagnosis was adenomatoid hyperplasia of the minor salivary glands. DISCUSSION Buccal localization of the adenomatoid hyperplasia of the minor salivary glands is quite uncommon in the literature. There are two cases in the English literature for our knowledge. In the clinical examination, the nodular and protuberated appearance of the lesion resembles buccal minor salivary gland tumors and vascular lesions. Histological analysis is fundamental to achieve correct diagnosis. CONCLUSION The differential diagnosis of buccal nodular, exophytic and colored mucosal lesions should include adenomatoid hyperplasia of the minor salivary glands. PMID:24727208

Dereci, Omur; Cimen, Emre

2014-01-01

421

Linking Pre-Diabetes with Benign Prostate Hyperplasia. IGFBP-3: A Conductor of Benign Prostate Hyperplasia Development Orchestra?  

PubMed Central

Benign prostatic hyperplasia (BPH) represents a pattern of non-malignant growth of prostatic fibromuscular stroma. Metabolic disturbances such us pre-diabetes and metabolic syndrome may have a role in BPH pathophysiology. A potential explanation for the above relationship involves the insulin-like growth factor (IGF) axis as well as IGF binding proteins, (IGFBPs) of which the most abundant form is IGFBP-3. Therefore, the aim of the present study was to investigate the association between intra-prostatic levels of IGF-1, IGF-2 as well as to evaluate the role of locally expressed IGFBP-3 in BPH development in pre-diabetes. A total of 49 patients admitted to the Urology department of a tertiary urban Greek hospital, for transurethral prostate resection, or prostatectomy and with pre-diabetes [impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) or both] were finally included. The majority of the sample consisted of subjects with IGT (51.0%), followed by IFG and IGT (32.7%) and isolated IFG (16.3%). For all participants a clinical examination was performed and blood samples were collected. In addition, total prostate (TP) volume or transitional zone (TZ) volume were estimated by transrectal ultrasonography. The results of the multivariate analysis regarding TP volume showed that higher PSA (p<0.001), larger waist circumference (p=0.007) and higher IGFBP-3 expression levels (p<0.001) independently predicted higher TP volume. The results regarding the volume of the TZ showed that higher PSA (p<0.001), larger waist circumference (p<0.001) and higher IGFBP-3 expression levels (p=0.024) were independently associated with higher TZ volume. Our findings show that intra-prostatic levels of IGFBP-3, PSA and waist circumference, but not overall obesity, are positively associated with prostate volume. IGFBP-3 seems to be a multifunctional protein, which can potentiate or inhibit IGF activity. PMID:24367483

Protopsaltis, Ioannis; Ploumidis, Achilles; Sergentanis, Theodoros N.; Constantoulakis, Padelis; Tzirogiannis, Kostantinos; Kyprianidou, Chrysoula; Papazafiropoulou, Athanasia K.; Melidonis, Andreas; Delakas, Dimitrios

2013-01-01

422

Initiating a regenerative response; cellular and molecular features of wound healing in the cnidarian Nematostella vectensis  

PubMed Central

Background Wound healing is the first stage of a series of cellular events that are necessary to initiate a regenerative response. Defective wound healing can block regeneration even in animals with a high regenerative capacity. Understanding how signals generated during wound healing promote regeneration of lost structures is highly important, considering that virtually all animals have the ability to heal but many lack the ability to regenerate missing structures. Cnidarians are the phylogenetic sister taxa to bilaterians and are highly regenerative animals. To gain a greater understanding of how early animals generate a regenerative response, we examined the cellular and molecular components involved during wound healing in the anthozoan cnidarian Nematostella vectensis. Results Pharmacological inhibition of extracellular signal-regulated kinases (ERK) signaling blocks regeneration and wound healing in Nematostella. We characterized early and late wound healing events through genome-wide microarray analysis, quantitative PCR, and in situ hybridization to identify potential wound healing targets. We identified a number of genes directly related to the wound healing response in other animals (metalloproteinases, growth factors, transcription factors) and suggest that glycoproteins (mucins and uromodulin) play a key role in early wound healing events. This study also identified a novel cnidarian-specific gene, for a thiamine biosynthesis enzyme (vitamin B synthesis), that may have been incorporated into the genome by lateral gene transfer from bacteria and now functions during wound healing. Lastly, we suggest that ERK signaling is a shared element of the early wound response for animals with a high regenerative capacity. Conclusions This research describes the temporal events involved during Nematostella wound healing, and provides a foundation for comparative analysis with other regenerative and non-regenerative species. We have shown that the same genes that heal puncture wounds are also activated after oral-aboral bisection, indicating a clear link with the initiation of regenerative healing. This study demonstrates the strength of using a forward approach (microarray) to characterize a developmental phenomenon (wound healing) at a phylogenetically important crossroad of animal evolution (cnidarian-bilaterian ancestor). Accumulation of data on the early wound healing events across numerous systems may provide clues as to why some animals have limited regenerative abilities. PMID:24670243

2014-01-01

423

The Nitroreductase System of Inducible Targeted Ablation Facilitates Cell-specific Regenerative Studies in Zebrafish  

PubMed Central

At the turn of the 20th century, classical regenerative biology – the study of organismal/tissue/limb regeneration in animals such as crayfish, snails, and planaria – garnered much attention. However, scientific luminaries such as Thomas Hunt Morgan eventually turned to other fields after concluding that inquiries into regenerative mechanisms were largely intractable beyond observational intrigues. The field of regeneration has enjoyed a resurgence in research activity at the turn of the 21st century, in large part due to “the promise” of cultured stem cells regarding reparative therapeutic approaches. Additionally, genomics-based methods that allow sophisticated genetic/molecular manipulations to be carried out in nearly any species have extended organismal regenerative biology well beyond observational limits. Throughout its history, complex paradigms such as limb regeneration – involving multiple tissue/cell types, thus, potentially multiple stem cell subtypes – have predominated the regenerative biology field. Conversely, cellular regeneration – the replacement of specific cell types – has been studied from only a few perspectives (predominantly muscle and mechanosensory hair cells). Yet, many of the degenerative diseases that regenerative biology hopes to address involve the loss of individual cell types; thus, a primary emphasis of the embryonic/induced stem cell field is defining culture conditions which promote cell-specific differentiation. Here we will discuss recent methodological approaches that promote the study of cell-specific regeneration. Such paradigms can reveal how the differentiation of specific cell types and regenerative potential of discrete stem cell niches are regulated. In particular, we will focus on how the nitroreductase (NTR) system of inducible targeted cell ablation facilitates: 1) large-scale genetic and chemical screens for identifying factors that regulate regeneration and, 2) in vivo time-lapse imaging experiments aimed at investigating regenerative processes more directly. Combining powerful screening and imaging technologies with targeted ablation systems can expand our understanding of how individual stem cell niches are regulated. The former approach promotes the development of therapies aimed at enhancing regenerative potentials in humans, the latter facilitates investigation of phenomena that are otherwise difficult to resolve, such as the role of cellular transdifferentiation or the innate immune system in regenerative paradigms. PMID:23542552

White, David T.; Mumm, Jeff S.

2013-01-01

424

The nitroreductase system of inducible targeted ablation facilitates cell-specific regenerative studies in zebrafish.  

PubMed

At the turn of the 20th century, classical regenerative biology--the study of organismal/tissue/limb regeneration in animals such as crayfish, snails, and planaria--garnered much attention. However, scientific luminaries such as Thomas Hunt Morgan eventually turned to other fields after concluding that inquiries into regenerative mechanisms were largely intractable beyond observational intrigues. The field of regeneration has enjoyed a resurgence in research activity at the turn of the 21st century, in large part due to "the promise" of cultured stem cells regarding reparative therapeutic approaches. Additionally, genomics-based methods that allow sophisticated genetic/molecular manipulations to be carried out in nearly any species have extended organismal regenerative biology well beyond observational limits. Throughout its history, complex paradigms such as limb regeneration--involving multiple tissue/cell types, thus, potentially multiple stem cell subtypes--have predominated the regenerative biology field. Conversely, cellular regeneration--the replacement of specific cell types--has been studied from only a few perspectives (predominantly muscle and mechanosensory hair cells). Yet, many of the degenerative diseases that regenerative biology hopes to address involve the loss of individual cell types; thus, a primary emphasis of the embryonic/induced stem cell field is defining culture conditions which promote cell-specific differentiation. Here we will discuss recent methodological approaches that promote the study of cell-specific regeneration. Such paradigms can reveal how the differentiation of specific cell types and regenerative potential of discrete stem cell niches are regulated. In particular, we will focus on how the nitroreductase (NTR) system of inducible targeted cell ablation facilitates: (1) large-scale genetic and chemical screens for identifying factors that regulate regeneration and (2) in vivo time-lapse imaging experiments aimed at investigating regenerative processes more directly. Combining powerful screening and imaging technologies with targeted ablation systems can expand our understanding of how individual stem cell niches are regulated. The former approach promotes the development of therapies aimed at enhancing regenerative potentials in humans, the latter facilitates investigation of phenomena that are otherwise difficult to resolve, such as the role of cellular transdifferentiation or the innate immune system in regenerative paradigms. PMID:23542552

White, David T; Mumm, Jeff S

2013-08-15

425

Optimization of the alignment sensitivity and energy stability of the NIF regenerative amplifier cavity/011  

SciTech Connect

The work to improve the energy stability of the regenerative amplifier (`regen`) for the National Ignition Facility is described. This includes a fast feed-forward system, designed to regulate the output energy of the regen by monitoring how quickly a pulse builds up over many round trips. Shot-to-shot energy fluctuations of all elements prior to (and including) the regen may be compensated for in this way, at the expense of a loss of approximately 50%. Also included is a detailed study into the alignment sensitivity of the regen cavity, with the goal of quantifying the effect of misalignment on the output energy. This is done by calculating the displacement of the eigenmode by augmenting the cavity ABCD matrix with the misalignment matrix elements, E, F. In this way, cavity misalignment issues due to thermal loading of the gain medium are investigated. Alternative cavity designs, which reduce the alignment sensitivity and therefore the energy drift over periods of continuous operation, are considered. Alterations to the amplifier head design are also considered.

Hopps, N. W., Atomic Weapons Research Establishment, Aldermaston, Great Britain

1998-06-24

426

Interleukin-driven insulin-like growth factor promotes prostatic inflammatory hyperplasia.  

PubMed

Prostatic inflammation is of considerable importance to urologic research because of its association with benign prostatic hyperplasia and prostate cancer. However, the mechanisms by which inflammation leads to proliferation and growth remain obscure. Here, we show that insulin-like growth factors (IGFs), previously known as critical developmental growth factors during prostate organogenesis, are induced by inflammation as part of the proliferative recovery to inflammation. Using genetic models and in vivo IGF receptor blockade, we demonstrate that the hyperplastic response to inflammation depends on interleukin-1-driven IGF signaling. We show that human prostatic hyperplasia is associated with IGF pathway activation specifically localized to foci of inflammation. This demonstrates that mechanisms of inflammation-induced epithelial proliferation and hyperplasia involve the induction of developmental growth factors, further establishing a link between inflammatory and developmental signals and providing a mechanistic basis for the management of proliferative diseases by IGF pathway modulation. PMID:25292180

Hahn, Alana M; Myers, Jason D; McFarland, Eliza K; Lee, Sanghee; Jerde, Travis J

2014-12-01

427

Photocarcinogenesis and persistent hyperplasia in UV-irradiated SENCAR mouse skin  

SciTech Connect

Susceptibility to photocarcinogenesis has been examined in several mouse strains and stocks including SENCAR, CD-1, BALB/c, C3H, C57Bl, and NZB. SENCAR mice are hypersusceptible to tumorigenesis caused by single high dose exposures to ultraviolet (UV) radiation but not by chronic low-dose exposures. SENCAR mice also exhibit an exaggerated and persistent epidermal hyperplasia in response to UV-induced tissue damage. The persistent hyperplasia is apparently due to a sustained proliferation of the epithelial basal cells, rather than to delayed cell differentiation. SENCAR mice did not exhibit persistent hyperplasia following other forms of tissue damage (surgical or thermal). In related studies, the levels of thymine dimers induced in SENCAR epidermis by UV radiation were comparable to those observed in BALB/c epidermis. In addition, no differences were found in the tissue distribution or persistence of thymine dimers in SENCAR and BALB/c skin.

Strickland, P.T.

1986-09-01

428

Altered protein expression in serum from endometrial hyperplasia and carcinoma patients  

PubMed Central

Background Endometrial carcinoma is one of the most common gynecological malignancies in women. The diagnosis of the disease at early or premalignant stages is crucial for the patient's prognosis. To date, diagnosis and follow-up of endometrial carcinoma and hyperplasia require invasive procedures. Therefore, there is considerable demand for the identification of biomarkers to allow non-invasive detection of these conditions. Methods In this study, we performed a quantitative proteomics analysis on serum samples from simple endometrial hyperplasia, complex endometrial hyperplasia, atypical endometrial hyperplasia, and endometrial carcinoma patients, as well as healthy women. Serum samples were first depleted of high-abundance proteins, labeled with isobaric tags (iTRAQ™), and then analyzed via two-dimensional liquid chromatography and tandem mass spectrometry. Protein identification and quantitation information were acquired by comparing the mass spectrometry data against the International Protein Index Database using ProteinPilot software. Bioinformatics annotation of identified proteins was performed by searching against the PANTHER database. Results In total, 74 proteins were identified and quantified in serum samples from endometrial lesion patients and healthy women. Using a 1.6-fold change as the benchmark, 12 proteins showed significantly altered expression levels in at least one disease group compared with healthy women. Among them, 7 proteins were found, for the first time, to be differentially expressed in atypical endometrial hyperplasia. These proteins are orosomucoid 1, haptoglobin, SERPINC 1, alpha-1-antichymotrypsin, apolipoprotein A-IV, inter-alpha-trypsin inhibitor heavy chain H4, and histidine-rich glycoprotein. Conclusions The differentially expressed proteins we discovered in this study may serve as biomarkers in the diagnosis and follow-up of endometrial hyperplasia and endometrial carcinoma. PMID:21489304

2011-01-01

429

Beneficial Effect of a Short-Acting NO Donor for the Prevention of Neointimal Hyperplasia  

PubMed Central

Nitric oxide (NO)-based therapies effectively inhibit neointimal hyperplasia in animal models of arterial injury and bypass grafting, but are not available clinically. We created a simple, effective, locally-applied NO-eluting therapy to prevent restenosis following vascular procedures. We investigated the efficacy of perivascular delivery of two different distinctly different diazeniumdiolate NO donors, 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), (short half-life) and diazeniumdiolated poly(acrylonitrile) (PAN/NO), (long half-life), in powder or gel form (30% poloxamer 407), at inhibiting neointimal hyperplasia using the rat carotid artery injury model. Two weeks post-injury, all of the NO-eluting therapies successfully reduced neointimal hyperplasia. However, most dramatically, PROLI/NO powder reduced intimal area by 91.2% (P<0.05) versus injury alone. PROLI/NO powder was noted to reduce the medial area (40.2% vs. injury alone, P<0.05), while other groups showed no such effect. Three days post-injury, each NO treatment group significantly reduced cellular proliferation. However, inflammatory markers revealed a distinct pattern: PAN/NO groups displayed increased leukocyte infiltration (P<0.05) whereas PROLI/NO groups displayed less macrophage infiltration (P<0.05). In conclusion, perivascular delivery of diazeniumdiolate NO donors in powder or gel form effectively inhibits neointimal hyperplasia. Application of short-acting PROLI/NO powder most effectively inhibited neointimal hyperplasia and inflammation and may represent a simple, clinically applicable NO-eluting therapy to prevent neointimal hyperplasia and restenosis following open vascular interventions. PMID:18045549

Pearce, Charles G.; Najjar, Samer F.; Kapadia, Muneera R.; Murar, Jozef; Eng, Jason; Lyle, Brian; Aalami, Oliver O.; Jiang, Qun; Hrabie, Joseph A.; Saavedra, Joseph E.; Keefer, Larry K.; Kibbe, Melina R.

2007-01-01

430

Adaptive scapula bone remodeling computational simulation: Relevance to regenerative medicine  

SciTech Connect

Shoulder arthroplasty success has been attributed to many factors including, bone quality, soft tissue balancing, surgeon experience, and implant design. Improved long-term success is primarily limited by glenoid implant loosening. Prosthesis design examines materials and shape and determines whether the design should withstand a lifetime of use. Finite element (FE) analyses have been extensively used to study stresses and strains produced in implants and bone. However, these static analyses only measure a moment in time and not the adaptive response to the altered environment produced by the therapeutic intervention. Computational analyses that integrate remodeling rules predict how bone will respond over time. Recent work has shown that subject-specific two- and three dimensional adaptive bone remodeling models are feasible and valid. Feasibility and validation were achieved computationally, simulating bone remodeling using an intact human scapula, initially resetting the scapular bone material properties to be uniform, numerically simulating sequential loading, and comparing the bone remodeling simulation results to the actual scapula’s material properties. Three-dimensional scapula FE bone model was created using volumetric computed tomography images. Muscle and joint load and boundary conditions were applied based on values reported in the literature. Internal bone remodeling was based on element strain-energy density. Initially, all bone elements were assigned a homogeneous density. All loads were applied for 10 iterations. After every iteration, each bone element’s remodeling stimulus was compared to its corresponding reference stimulus and its material properties modified. The simulation achieved convergence. At the end of the simulation the predicted and actual specimen bone apparent density were plotted and compared. Location of high and low predicted bone density was comparable to the actual specimen. High predicted bone density was greater than actual specimen. Low predicted bone density was lower than actual specimen. Differences were probably due to applied muscle and joint reaction loads, boundary conditions, and values of constants used. Work is underway to study this. Nonetheless, the results demonstrate three dimensional bone remodeling simulation validity and potential. Such adaptive predictions take physiological bone remodeling simulations one step closer to reality. Computational analyses are needed that integrate biological remodeling rules and predict how bone will respond over time. We expect the combination of computational static stress analyses together with adaptive bone remodeling simulations to become effective tools for regenerative medicine research.

Sharma, Gulshan B., E-mail: gbsharma@ucalgary.ca [Emory University, Department of Radiology and Imaging Sciences, Spine and Orthopaedic Center, Atlanta, Georgia 30329 (United States); University of Pittsburgh, Swanson School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213 (United States); University of Calgary, Schulich School of Engineering, Department of Mechanical and Manufacturing Engineering, Calgary, Alberta T2N 1N4 (Canada); Robertson, Douglas D., E-mail: douglas.d.robertson@emory.edu [Emory University, Department of Radiology and Imaging Sciences, Spine and Orthopaedic Center, Atlanta, Georgia 30329 (United States); University of Pittsburgh, Swanson School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213 (United States)

2013-07-01

431

The Medical Home Concept and Congenital Adrenal Hyperplasia: A Comfortable Habitat!  

PubMed Central

Patient-centered interdisciplinary health care for children with chronic medical disorders represents an evolution from the traditional “stop and go” treatment for acute illnesses. This model for health care delivery has been called the “medical home,” a concept that was originally developed in pediatrics for the care of children with special needs. Patient and family-centered, comprehensive, interdisciplinary, culturally effective, and readily accessible health care delivery is desirable for the care of children with congenital adrenal hyperplasia. As children with congenital adrenal hyperplasia (CAH) become adolescents and young adults, transfer of this health care delivery model to adult endocrinologists is appropriate. PMID:20628559

Witchel, Selma Feldman

2010-01-01

432

Large telangiectatic focal nodular hyperplasia presenting with normal radionuclide studies: Case report  

SciTech Connect

A 9 cm-lesion of telangiectatic focal nodular hyperplasia was incidentally identified in a 31-yr-old female. Despite a typical appearance by X-ray computed tomography and ultrasonography, scintigraphy with technetium-99m-({sup 99m}Tc) colloid, {sup 99m}Tc-diethyliminodiacetic acid, and {sup 99m}Tc-labeled red cells failed to demonstrate any abnormalities. These findings are felt to reflect the relative lack of architectural disruption that histologically characterizes this particular lesion. The present report described the imaging characteristics of the telangiectatic form of focal nodular hyperplasia.

Peterfy, C.G.; Rosenthall, L. (Montreal General Hospital (Canada))

1990-12-01

433

Transcatheter Arterial Embolization as a Safe and Effective Treatment for Focal Nodular Hyperplasia of the Liver  

SciTech Connect

When surgical treatment is being considered for focal nodular hyperplasia, the risk of liver surgery must be carefully balanced against the benefit of resection, especially in the case of a large or centrally located lesion. However, when resection is contraindicated or even impossible, transcatheter arterial embolization should be considered as a safe and less invasive alternative treatment.We describe two cases of young women who presented with abdominal pain and a hypervascular enhancing mass with the radiologic features of focal nodular hyperplasia. Arterial embolization was the therapy selected due to the risk of surgery. In both cases the procedure was successful, and the lesion showed shrinkage during follow-up.

Terkivatan, Tuerkan [Department of Surgery, ErasmusMedical Center of Rotterdam-Dijkzigt, Dr. Molewaterplein 40, 3015GD Rotterdam (Netherlands); Hussain, Shahid M.; Lameris, Johan S. [Department of Radiology, ErasmusMedical Center of Rotterdam-Dijkzigt, Dr. Molewaterplein 40, 3015GD Rotterdam (Netherlands); Ijzermans, Jan N.M. [Department of Surgery, ErasmusMedical Center of Rotterdam-Dijkzigt, Dr. Molewaterplein 40, 3015GD Rotterdam (Netherlands)

2002-10-15

434

Symptomatic and asymptomatic benign prostatic hyperplasia: Molecular differentiation by using microarrays  

NASA Astrophysics Data System (ADS)

Benign prostatic hyperplasia (BPH) is a disease of unknown etiology that significantly affects the quality of life in aging men. Histologic BPH may present itself either as symptomatic or asymptomatic in nature. To elucidate the molecular differences underlying BPH, gene expression profiles from the prostate transition zone tissue have been analyzed by using microarrays. A set of 511 differentially expressed genes distinguished symptomatic and asymptomatic BPH. This genetic signature separates BPH from normal tissue but does not seem to change with age. These data could provide novel approaches for alleviating symptoms and hyperplasia in BPH.

Prakash, Kulkarni; Pirozzi, Gregorio; Elashoff, Michael; Munger, William; Waga, Iwao; Dhir, Rajiv; Kakehi, Yoshiyuki; Getzenberg, Robert H.

2002-05-01

435

Adrenal myelolipomas composed with adrenal nodular hyperplasia in the same gland.  

PubMed

Adrenal myelolipoma is a benign neoplasm composed of an admixture of hemopoietic elements and mature adipose tissue. The incidence of adrenal myelolipoma is reported as between 4% and 5% of adrenal incidentaloma. The association of an adrenal myelolipoma and adrenal nodular hyperplasia or adrenal adenoma is rare. Four cases of adrenal myelolipomas in the material of 702 incidentally discovered adrenal lesions treated in our center are presented in this paper (in a group of 294 operated patients). Two myelolipomas have been reported as isolated adrenal masses and two - in association with adrenocortical nodular hyperplasia. PMID:22535606

Babinska, Anna; Na?ecz, Adam; Swiatkowska-Stodulska, Renata; Sworczak, Krzysztof

2012-03-01

436

Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia.  

PubMed

The thymus is implicated as an organ that contributes to autoimmunity in myasthenia gravis (MG) patients. Hassall's corpuscles (HCs) are assumed to represent the terminally differentiated stage of medullary thymic epithelial cells (mTECs). By using multicolor immunohistofluorescence analysis, we examined HCs in thymuses that were therapeutically excised from MG (+) and MG (-) patients. We found that the number of HCs per unit area of the thymic medulla was significantly elevated in the thymuses of MG (+) patients with thymic hyperplasia. CCL21 expression increased in the hyperplastic MG thymuses. We speculate that the altered differentiation of mTECs is associated with the thymic hyperplasia and the onset of MG. PMID:24556356

Matsui, Naoko; Ohigashi, Izumi; Tanaka, Keijirou; Sakata, Mie; Furukawa, Takahiro; Nakagawa, Yasushi; Kondo, Kazuya; Kitagawa, Tetsuya; Yamashita, Sumimasa; Nomura, Yoshiko; Takahama, Yousuke; Kaji, Ryuji

2014-04-15

437

Generation of thyroid follicular cells from pluripotent stem cells: potential for regenerative medicine.  

PubMed

Nearly 12% of the population in the United States will be afflicted with a thyroid related disorder during their lifetime. Common treatment approaches are tailored to the specific disorder and include surgery, radioactive iodine ablation, antithyroid drugs, thyroid hormone replacement, external beam radiation, and chemotherapy. Regenerative medicine endeavors to combat disease by replacing or regenerating damaged, diseased, or dysfunctional body parts. A series of achievements in pluripotent stem cell research have transformed regenerative medicine in many ways by demonstrating "repair" of a number of body parts in mice, of which, the thyroid has now been inducted into this special group. Seminal work in pluripotent cells, namely embryonic stem cells and induced pluripotent stem cells, have made possible their path to becoming key tools and biological building blocks for cell-based regenerative medicine to combat the gamut of human diseases, including those affecting the thyroid. PMID:24995001

Sewell, Will; Lin, Reigh-Yi

2014-01-01

438

Regeneration experiments below 10K in a regenerative-cycle cryocooler  

NASA Technical Reports Server (NTRS)

At temperatures below 10K, regenerative cycle cryocoolers are limited by regeneration losses in the helium working fluid which result from the decreasing heat capacity of the regenerating material and the increasing density of helium. Experiments examining several approaches to improving the low-temperature regeneration in a four-stage regenerative cycle cooler constructed primarily of fiberglass materials are discussed. Using an interchangeable fourth stage, the experiments included configurations with multiple regeneration passages, and a static helium volume for increased heat capacity. Experiments using helium-3 as the working fluid and a Malone stage are planned. Results indicate that, using these techniques, it should be possible to construct a regenerative cycle cooler which will operate below 6K.

Sager, R. E.; Paulson, D. N.

1983-01-01

439

Capacitor regenerative braking system of electric wheelchair for senior citizen based on variable frequency chopper control.  

PubMed

This paper proposes a novel regenerative braking control system of electric wheelchairs for senior citizen. "Electric powered wheelchair", which generates the driving force by electric motors according to the human operation, is expected to be widely used as a mobility support system for elderly people. This study focuses on the braking control to realize the safety and smooth stopping motion using the regenerative braking control technique based on fuzzy algorithm. The ride quality improvement and energy recycling can be expected by the proposed control system with stopping distance estimation and variable frequency control on the step-up/down chopper type of capacitor regenerative circuit. Some driving experiments confirm the effectiveness of the proposed control system. PMID:19964689

Takahashi, Yoshiaki; Seki, Hirokazu

2009-01-01

440

Downward Slope Driving Control for Electric Powered Wheelchair Based on Capacitor Regenerative Brake  

NASA Astrophysics Data System (ADS)

This paper describes a novel capacitor regenerative braking control scheme of electric powered wheelchairs for efficient driving on downward slopes. An electric powered wheelchair, which generates the driving force by electric motors, is expected to be widely used as a mobility support system for elderly people and disabled people; however the energy efficiency has to be further improved because it is driven only by battery energy. This study proposes a capacitor regenerative braking circuit and two types of velocity control schemes with variable duty ratio. The proposed regenerative braking circuit is based on the step-up/down circuit with additional resistance and connects right and left motors in series in order to obtain a larger braking power. Some driving experiments on a practical downward slope show the effectiveness of the proposed control system.

Seki, Hirokazu; Takahashi, Yoshiaki

441

Regenerative therapy and tissue engineering for the treatment of end-stage cardiac failure  

PubMed Central

Regeneration of myocardium through regenerative therapy and tissue engineering is appearing as a prospective treatment modality for patients with end-stage heart failure. Focusing on this area, this review highlights the new developments and challenges in the regeneration of myocardial tissue. The role of various cell sources, calcium ion and cytokine on the functional performance of regenerative therapy is discussed. The evolution of tissue engineering and the role of tissue matrix/scaffold, cell adhesion and vascularisation on tissue engineering of cardiac tissue implant are also discussed. PMID:23507781

Finosh, G.T.; Jayabalan, Muthu

2012-01-01

442

Converging lines of inquiry CardiovasCular researCH | regenerative mediCine | lower great lakes eCosystems  

E-print Network

heart attack and stroke the promise of regenerative medicine Lower Great Lakes and Niagara River 24 natural resource--the Great Lakes and their connecting channels, which form the largest fresh surfaceFocus: Converging lines of inquiry CardiovasCular researCH | regenerative mediCine | lower great

Krovi, Venkat

443

Energy Delivery Systems for Treatment of Benign Prostatic Hyperplasia  

PubMed Central

Executive Summary Objective The Ontario Health Technology Advisory Committee asked the Medical Advisory Secretariat (MAS) to conduct a health technology assessment on energy delivery systems for the treatment of benign prostatic hyperplasia (BPH). Clinical Need: Target Population and Condition BPH is a noncancerous enlargement of the prostate gland and the most common benign tumour in aging men. (1) It is the most common cause of lower urinary tract symptoms (LUTS) and bladder outlet obstruction (BOO) and is an important cause of diminished quality of life among aging men. (2) The primary goal in the management of BPH for most patients is a subjective improvement in urinary symptoms and quality of life. Until the 1930s, open prostatectomy, though invasive, was the most effective form of surgical treatment for BPH. Today, the benchmark surgical treatment for BPH is transurethral resection of the prostate (TURP), which produces significant changes of all subjective and objective outcome parameters. Complications after TURP include hemorrhage during or after the procedure, which often necessitates blood transfusion; transurethral resection (TUR) syndrome; urinary incontinence; bladder neck stricture; and sexual dysfunction. A retrospective review of 4,031 TURP procedures performed by one surgeon between 1979 and 2003 showed that the incidence of complications was 2.4% for blood transfusion, 0.3% for TUR syndrome, 1.5% for hemostatic procedures, 2.8% for bladder neck contracture, and 1% for urinary stricture. However, the incidence of blood transfusion and TUR syndrome decreased as the surgeon’s skills improved. During the 1990s, a variety of endoscopic techniques using a range of energy sources have been developed as alternative treatments for BPH. These techniques include the use of light amplification by stimulated emission of radiation (laser), radiofrequency, microwave, and ultrasound, to heat prostate tissue and cause coagulation or vaporization. In addition, new electrosurgical techniques that use higher amounts of energy to cut, coagulate, and vaporize prostatic tissue have entered the market as competitors to TURP. The driving force behind these new treatment modalities is the potential of producing good hemostasis, thereby reducing catheterization time and length of hospital stay. Some have the potential to be used in an office environment and performed under local anesthesia. Therefore, these new procedures have the potential to rival TURP if their effectiveness is proven over the long term. The Technology Being Reviewed The following energy-based techniques were considered for assessment: transurethral electrovaporization of the prostate (TUVP) transurethral electrovapor resection of the prostate (TUVRP) transurethral electrovaporization of the prostate using bipolar energy (plasmakinetic vaporization of the prostate [PKVP]) visual laser ablation of the prostate (VLAP) transurethral ultrasound guided laser incision prostatectomy (TULIP) contact laser vaporization of the prostate (CLV) interstitial laser coagulation (ILC) holmium laser resection of the prostate (HoLRP) holmium laser enucleation of the prostate (HoLEP) holmium laser ablation of the prostate (HoLAP) potassium titanyl phosphate (KTP) laser transurethral microwave thermotherapy (TUMT) transurethral needle ablation (TUNA) Review Strategy A search of electronic databases (OVID MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, EMBASE, The Cochrane Library, and the International Agency for Health Technology Assessment [INAHTA] database) was undertaken to identify evidence published from January 1, 2000 to June 21, 2006. The search was limited to English-language articles and human studies. The literature search identified 284 citations, of which 38 randomized controlled trials (RCTs) met the inclusion criteria. Since the application of high-power (80 W) KTP laser (photoselective vaporization of the prostate [PVP]) has been supported in the United States and has resulted in a rapid diffusion of this technology in the absence of any RCTs, th

2006-01-01

444

Adjunctive arterial injury and photodynamic therapy with aluminium disulphonated phthalocyanine inhibits intimal hyperplasia  

NASA Astrophysics Data System (ADS)

Photodynamic therapy (PDT) of proliferative vascular smooth muscle cells (SMC) reduces intimal hyperplasia (FCIH). We assess the effects of adjunctive balloon injury and immediate PDT on contractile SMC, using aluminum disulphonated phthalocyanine (AlS2Pc) sensitization, on intimal hyperplasia. Groups of 5 Wistar rats underwent tail vein injection with 2.5 mg/kg of aluminum disulphonated phthalocyanine (AlS2Pc). Standard carotid artery balloon injury was performed with a 2FG Fogarty embolectomy catheter and the artery irradiated with 50 J/cm2. Control groups were also studied. Rats were killed at 2 and 4 weeks after treatment and perfusion fixed H&E stained cross-sections assessed by computerized morphometric measurements. Three sections per rat were analyzed. PDT treated arteries were free of FCIH formation in all cases. Laser alone (and to a lesser extent sensitizer alone) produced some reduction in the levels of FCIH compared to untreated but balloon injured v