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Sample records for relevant cover factor

  1. 28 CFR 51.57 - Relevant factors.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Relevant factors. 51.57 Section 51.57 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR THE ADMINISTRATION OF SECTION 5 OF THE VOTING RIGHTS ACT OF 1965, AS AMENDED Determinations by the Attorney General § 51.57 Relevant factors. Among the factors the Attorney...

  2. Predicting the presence and cover of management relevant invasive plant species on protected areas.

    PubMed

    Iacona, Gwenllian; Price, Franklin D; Armsworth, Paul R

    2016-01-15

    Invasive species are a management concern on protected areas worldwide. Conservation managers need to predict infestations of invasive plants they aim to treat if they want to plan for long term management. Many studies predict the presence of invasive species, but predictions of cover are more relevant for management. Here we examined how predictors of invasive plant presence and cover differ across species that vary in their management priority. To do so, we used data on management effort and cover of invasive plant species on central Florida protected areas. Using a zero-inflated multiple regression framework, we showed that protected area features can predict the presence and cover of the focal species but the same features rarely explain both. There were several predictors of either presence or cover that were important across multiple species. Protected areas with three days of frost per year or fewer were more likely to have occurrences of four of the six focal species. When invasive plants were present, their proportional cover was greater on small preserves for all species, and varied with surrounding household density for three species. None of the predictive features were clearly related to whether species were prioritized for management or not. Our results suggest that predictors of cover and presence can differ both within and across species but do not covary with management priority. We conclude that conservation managers need to select predictors of invasion with care as species identity can determine the relationship between predictors of presence and the more management relevant predictors of cover. PMID:26599567

  3. The dust covering factor in active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Stalevski, Marko; Ricci, Claudio; Ueda, Yoshihiro; Lira, Paulina; Fritz, Jacopo; Baes, Maarten

    2016-05-01

    The primary source of emission of active galactic nuclei (AGNs), the accretion disc, is surrounded by an optically and geometrically thick dusty structure (`the so-called dusty torus'). The infrared radiation emitted by the dust is nothing but a reprocessed fraction of the accretion disc emission, so the ratio of the torus to the AGN luminosity (Ltorus/LAGN) should corresponds to the fraction of the sky obscured by dust, i.e. the covering factor. We undertook a critical investigation of the Ltorus/LAGN as the dust covering factor proxy. Using state-of-the-art 3D Monte Carlo radiative transfer code, we calculated a grid of spectral energy distributions (SEDs) emitted by the clumpy two-phase dusty structure. With this grid of SEDs, we studied the relation between Ltorus/LAGN and the dust covering factor for different parameters of the torus. We found that in the case of type 1 AGNs the torus anisotropy makes Ltorus/LAGN underestimate low covering factors and overestimate high covering factors. In type 2 AGNs Ltorus/LAGN always underestimates covering factors. Our results provide a novel easy-to-use method to account for anisotropy and obtain correct covering factors. Using two samples from the literature, we demonstrated the importance of our result for inferring the obscured AGN fraction. We found that after the anisotropy is properly accounted for, the dust covering factors show very weak dependence on LAGN, with values in the range of ≈0.6-0.7. Our results also suggest a higher fraction of obscured AGNs at high luminosities than those found by X-ray surveys, in part owing to the presence of a Compton-thick AGN population predicted by population synthesis models.

  4. Quantifying environmental limiting factors on tree cover using geospatial data.

    PubMed

    Greenberg, Jonathan A; Santos, Maria J; Dobrowski, Solomon Z; Vanderbilt, Vern C; Ustin, Susan L

    2015-01-01

    Environmental limiting factors (ELFs) are the thresholds that determine the maximum or minimum biological response for a given suite of environmental conditions. We asked the following questions: 1) Can we detect ELFs on percent tree cover across the eastern slopes of the Lake Tahoe Basin, NV? 2) How are the ELFs distributed spatially? 3) To what extent are unmeasured environmental factors limiting tree cover? ELFs are difficult to quantify as they require significant sample sizes. We addressed this by using geospatial data over a relatively large spatial extent, where the wall-to-wall sampling ensures the inclusion of rare data points which define the minimum or maximum response to environmental factors. We tested mean temperature, minimum temperature, potential evapotranspiration (PET) and PET minus precipitation (PET-P) as potential limiting factors on percent tree cover. We found that the study area showed system-wide limitations on tree cover, and each of the factors showed evidence of being limiting on tree cover. However, only 1.2% of the total area appeared to be limited by the four (4) environmental factors, suggesting other unmeasured factors are limiting much of the tree cover in the study area. Where sites were near their theoretical maximum, non-forest sites (tree cover < 25%) were primarily limited by cold mean temperatures, open-canopy forest sites (tree cover between 25% and 60%) were primarily limited by evaporative demand, and closed-canopy forests were not limited by any particular environmental factor. The detection of ELFs is necessary in order to fully understand the width of limitations that species experience within their geographic range. PMID:25692604

  5. The Relevant Factors in Promoting Reading Activities in Elementary Schools

    ERIC Educational Resources Information Center

    Huang, Han-Chen; Tsai, Yao-Hsu; Huang, Shih-Hsiang

    2015-01-01

    In order to help students absorb knowledge, schools often conduct reading activities. Thorough planning and strategies, however, are needed to insure the effect of reading promotions, and make them a deeply-rooted part of life. This study adopted the analytic hierarchy process (AHP) to discuss the relevant factors in promoting reading activities…

  6. Directional reflectance factor distributions for cover types of Northern Africa

    NASA Technical Reports Server (NTRS)

    Kimes, D. S.; Newcomb, W. W.; Tucker, C. J.; Zonneveld, I. S.; Van Wijngaarden, W.

    1985-01-01

    Directional reflectance factors that spanned the entire exitance hemisphere were collected on the ground throughout the morning period for common cover types in Tunisia, Africa. NOAA 7/8 AVHRR bands 1(0.58-0.68 micron) and 2 (0.7301.1 micron) were used in data collection. The cover types reported were a plowed field, annual grassland, steppe grassland, hard wheat, salt plain, and irrigated wheat. Several of these cover types had geometric structures that are extreme as compared to those reported in the literature. Comparisons were made between the dynamics of the observed reflectance distributions and those reported in the literature. It was found that the dynamics of the measured data could be explained by a combination of soil and vegetation scattering components. The data and analysis further validated physical principles that cause the reflectance distribution dynamics as proposed by field and simulation studies in the literature. Finally, the normalized difference transformation (Band 2 - Band 1)/(Band 1 + Band 2), which is useful in monitoring vegetation cover, generally decreased the variation in signal with changing view angle. However, several exceptions were noted.

  7. Dissociative absorption: An empirically unique, clinically relevant, dissociative factor.

    PubMed

    Soffer-Dudek, Nirit; Lassri, Dana; Soffer-Dudek, Nir; Shahar, Golan

    2015-11-01

    Research of dissociative absorption has raised two questions: (a) Is absorption a unique dissociative factor within a three-factor structure, or a part of one general dissociative factor? Even when three factors are found, the specificity of the absorption factor is questionable. (b) Is absorption implicated in psychopathology? Although commonly viewed as "non-clinical" dissociation, absorption was recently hypothesized to be specifically associated with obsessive-compulsive symptoms. To address these questions, we conducted exploratory and confirmatory factor analyses on 679 undergraduates. Analyses supported the three-factor model, and a "purified" absorption scale was extracted from the original inclusive absorption factor. The purified scale predicted several psychopathology scales. As hypothesized, absorption was a stronger predictor of obsessive-compulsive symptoms than of general psychopathology. In addition, absorption was the only dissociative scale that longitudinally predicted obsessive-compulsive symptoms. We conclude that absorption is a unique and clinically relevant dissociative tendency that is particularly meaningful to obsessive-compulsive symptoms. PMID:26241024

  8. Spectral, spatial and radiometric factors in cover type discrimination

    NASA Technical Reports Server (NTRS)

    Alexander, D.; Buis, J.; Acevedo, W.; Wrigley, R.

    1983-01-01

    The influence of spatial, spectral, and radiometric resolutions on the utilization of Thematic Mapper (TM) and Multispectral Scanner (MSS) data is assessed quantitatively using a 2 x 2 x 2 factorial design experiment. Eight possible factor combinations were examined for agricultural, urban, forestry, range, and water types of land covers for three levels of information. Spectral bandwidths were configured to simulate all four Landsat MSS channels and Landsat TM channels 1, 2, 3, 4, and 7. By means of bar charts and tables it is shown that the 8-bit radiometric and 75-meter spatial resolutions provide a higher overall accuracy than the 6-bit radiometric and 25-meter spatial resolutions. Spectrally, the difference between the four MSS channels and five TM channel configurations is noted to be insignificant.

  9. Factors relevant to utility integration of intermittent renewable technologies

    SciTech Connect

    Wan, Yih-huei; Parsons, B.K.

    1993-08-01

    This study assesses factors that utilities must address when they integrate intermittent renewable technologies into their power-supply systems; it also reviews the literature in this area and has a bibliography containing more than 350 listings. Three topics are covered: (1) interface (hardware and design-related interconnection), (2) operability/stability, and (3) planning. This study finds that several commonly held perceptions regarding integration of intermittent renewable energy technologies are not valid. Among findings of the study are the following: (1) hardware and system design advances have eliminated most concerns about interface; (2) cost penalties have not occurred at low to moderate penetration levels (and high levels are feasible); and (3) intermittent renewable energy technologies can have capacity values. Obstacles still interfering with intermittent renewable technologies are also identified.

  10. THE EVOLUTION OF THE DUSTY TORUS COVERING FACTOR IN QUASARS

    SciTech Connect

    Gu Minfeng

    2013-08-20

    We have assembled a large sample of 5996 quasars at 2.0 {<=} z {<=} 2.4 (high-z) or 0.7 {<=} z {<=} 1.1 (low-z) from the Sloan Digital Sky Survey (SDSS) ninth and seventh data release and quasar catalogs. The spectral energy distributions of quasars were constructed by collecting WISE, UKIDSS, and GALEX photometric data in addition to SDSS data, from which the IR luminosity at 1-7 {mu}m and bolometric luminosity at 1100 A-1 {mu}m were calculated. A red tail is clearly seen in the distribution of the spectral index over 1100 A-1 {mu}m for both the high-z and low-z sources; this tail is likely due to red or reddened quasars. The covering factor (CF) of the dusty torus is estimated as the ratio of the IR luminosity to the bolometric luminosity. We find significant anti-correlations between the CF and the bolometric luminosity, in both the high-z and low-z quasars; however, these two groups follow different tracks. At overlapping bolometric luminosities, the CF of high-z quasars is systematically larger than those of low-z quasars, implying an evolution of the CF with redshift.

  11. A method for the selection of relevant pattern indices for monitoring of spatial forest cover pattern at a regional scale

    NASA Astrophysics Data System (ADS)

    De Clercq, Eva M.; Vandemoortele, Femke; De Wulf, Robert R.

    2006-06-01

    When signing Agenda 21, several countries agreed to monitor the status of forests to ensure their sustainable use. For reporting on the change in spatial forest cover pattern on a regional scale, pattern metrics are widely used. These indices are not often thoroughly evaluated as to their sensitivity to remote sensing data characteristics. Hence, one would not know whether the change in the metric values was due to actual landscape pattern changes or to characteristic variation of multitemporal remote sensing data. The objective of this study is to empirically test an array of pattern metrics for the monitoring of spatial forest cover. Different user requirements are used as point of departure. This proved to be a straightforward method for selecting relevant pattern indices. We strongly encourage the systematic screening of these indices prior to use in order to get a deeper understanding of the results obtained by them.

  12. The effects of space relevant environmental factors on halophilic Archaea

    NASA Astrophysics Data System (ADS)

    Leuko, Stefan; Moeller, Ralf; Rettberg, Petra

    Within the last 50 years, space technology has provided tools for transporting terrestrial (microbial) life beyond Earth's protective shield in order to study its responses to selected conditions of space. Microorganisms are ubiquitous and can be found in almost every environment on Earth. They thrive and survive in a broad spectrum of environments and are true masters in adapting to rapidly changing external conditions. Although microorganisms cannot actively grow under the harsh conditions of outer space or other known planets, some microorganisms might be able to survive for a time in space or other planets as dormant, inactive spores or in similar desiccation-resistant resting states, e.g., enclosed in halite crystals or biofilms. Halite crystals are the realm of halophilic Archaea as they have adapted to life at extreme salt concentrations. They can stay entrapped in such crystals for millions of years without losing viability and therefore the family Halobacteriaceae belongs to the group of microorganisms which may survive space travel or may even be found on other planets. Several members of this family have been utilized in space relevant experiments where they were exposed to detrimental environmental conditions such as UV-C radiation, vacuum, temperature cycles (+60(°) C and -25(°) C) and heavy iron bombardment (150 MeV He, 500 MeV Ar and 500 MeV Fe ions). The viability was evaluated by colony forming unit (cfu) counts as well as with the LIFE/DEAD kit. Results revealed that UV-C radiation (up to 1.000 J/m (2) ) has a considerable effect on the viability, whereas the other tested parameters inflict little damage onto the organisms. Repair of UV-C inflicted damage is efficient and several DNA damage repair genes are up-regulated following exposure. Halophilic archaea display a strong resistance against heavy iron bombardment, with dosages of up to 2.000 Gy 500 MeV Fe ions needed to establish a visible effect on the vitality. Genomic integrity after

  13. Land cover as an important factor for landslide risk assessment

    NASA Astrophysics Data System (ADS)

    Promper, C.; Glade, T.; Puissant, A.; Malet, J.-P.

    2012-04-01

    Landcover change is a crucial component of hazard and vulnerability in terms of quantification of possible future landslide risk, and the importance for spatial planners but also individuals is obvious. Damage of property, losses of agricultural land, loss of production but also damaged infrastructures and fatalities may be the result of landslide hazards. To avoid these economic damages as well as possible fatalities in the future, a method of assessing spatial but also temporal patterns of landslides is necessary. This study represents results of landcover modeling as a first step to the proposition of scenario of landslide risk for the future. The method used for future land cover analysis is the CLUE modeling framework combining past and actual observed landcover conditions. The model is based on a statistical relationship between the actual land cover and driving forces. The allocation of landcover pixel is modified by possible autonomous developments and competition between land use types. (Verburg et al. 1999) The study area is located in a district in the alpine foreland of Lower Austria: Waidhofen/Ybbs, of about 130km2. The topography is characterized by narrow valleys, flat plateau and steep slopes. The landcover is characterized by region of densely populated areas in the valley bottom along the Ybbs River, and a series of separated farm houses on the top of the plateau. Population density is about 90 persons / km2 which represent the observed population density of Austria. The initial landcover includes forest, grassland, culture, built-up areas and individual farms. Most of the observed developments are controlled by the topography (along the valleys) and the actual road network. The results of the landcover model show different scenarios of changes in the landslide prone landcover types. These maps will be implemented into hazard analysis but also into vulnerability assessment regarding elements at risk. Verburg, P.H., de Koning, G.H.J., Kok, K

  14. Covering factors of the dusty obscurers in radio-loud and radio-quiet quasars

    NASA Astrophysics Data System (ADS)

    Gupta, Maitrayee; Sikora, Marek; Nalewajko, Krzysztof

    2016-09-01

    We compare covering factors of circumnuclear dusty obscurers in radio-loud and radio-quiet quasars. The radio-loud quasars are represented by a sample of FR II quasars obtained by cross-matching a catalog of the FR II radio sources selected by van Velzen et al. with the SDSS DR7 catalog of quasars. Covering factors of FR II quasars are compared with covering factors of the radio-quiet quasars matched with them in redshift, black hole mass, and Eddington-ratio. We found that covering factors, proxied by the infrared-to-bolometric luminosity ratio, are on average slightly smaller in FR II quasars than in radio-quiet quasars, however, this difference is statistically significant only for the highest Eddington ratios. For both samples, no statistically significant dependence of a median covering factor on Eddington ratio, black hole mass, nor redshift can be claimed.

  15. Pathologically Relevant Prelamin A Interactions with Transcription Factors.

    PubMed

    Infante, Arantza; Rodríguez, Clara I

    2016-01-01

    LMNA-linked laminopathies are a group of rare human diseases caused by mutations in LMNA or by disrupted posttranslational processing of its largest encoded isoform, prelamin A. The accumulation of mutated or immature forms of farnesylated prelamin A, named progerin or prelamin A, respectively, dominantly disrupts nuclear lamina structure with toxic effects in cells. One hypothesis is that aberrant lamin filament networks disrupt or "trap" proteins such as transcription factors, thereby interfering with their normal activity. Since laminopathies mainly affect tissues of mesenchymal origin, we tested this hypothesis by generating an experimental model of laminopathy by inducing prelamin A accumulation in human mesenchymal stem cells (hMSCs). We provide detailed protocols for inducing and detecting prelamin A accumulation in hMSCs, and describe the bioinformatic analysis and in vitro assays of transcription factors potentially affected by prelamin A accumulation. PMID:26778572

  16. 21 CFR 315.3 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 5 2014-04-01 2014-04-01 false General factors relevant to safety and effectiveness. 315.3 Section 315.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE DIAGNOSTIC RADIOPHARMACEUTICALS § 315.3 General factors relevant to safety and effectiveness....

  17. 21 CFR 601.32 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SERVICES (CONTINUED) BIOLOGICS LICENSING Diagnostic Radiopharmaceuticals § 601.32 General factors relevant to safety and effectiveness. FDA's determination of the safety and effectiveness of a diagnostic radiopharmaceutical includes consideration of the following: (a) The proposed use of the...

  18. 21 CFR 601.32 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... SERVICES (CONTINUED) BIOLOGICS LICENSING Diagnostic Radiopharmaceuticals § 601.32 General factors relevant to safety and effectiveness. FDA's determination of the safety and effectiveness of a diagnostic radiopharmaceutical includes consideration of the following: (a) The proposed use of the...

  19. 21 CFR 601.32 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... SERVICES (CONTINUED) BIOLOGICS LICENSING Diagnostic Radiopharmaceuticals § 601.32 General factors relevant to safety and effectiveness. FDA's determination of the safety and effectiveness of a diagnostic radiopharmaceutical includes consideration of the following: (a) The proposed use of the...

  20. Determining the Covering Factor of Compton-thick Active Galactic Nuclei with NuSTAR

    NASA Astrophysics Data System (ADS)

    Brightman, M.; Baloković, M.; Stern, D.; Arévalo, P.; Ballantyne, D. R.; Bauer, F. E.; Boggs, S. E.; Craig, W. W.; Christensen, F. E.; Comastri, A.; Fuerst, F.; Gandhi, P.; Hailey, C. J.; Harrison, F. A.; Hickox, R. C.; Koss, M.; LaMassa, S.; Puccetti, S.; Rivers, E.; Vasudevan, R.; Walton, D. J.; Zhang, W. W.

    2015-05-01

    The covering factor of Compton-thick (CT) obscuring material associated with the torus in active galactic nuclei (AGNs) is at present best understood through the fraction of sources exhibiting CT absorption along the line of sight (NH > 1.5 × 1024 cm-2) in the X-ray band, which reveals the average covering factor. Determining this CT fraction is difficult, however, due to the extreme obscuration. With its spectral coverage at hard X-rays (>10 keV), Nuclear Spectroscopic Telescope Array (NuSTAR) is sensitive to the AGNs covering factor since Compton scattering of X-rays off optically thick material dominates at these energies. We present a spectral analysis of 10 AGNs observed with NuSTAR where the obscuring medium is optically thick to Compton scattering, so-called CT AGNs. We use the torus models of Brightman & Nandra that predict the X-ray spectrum from reprocessing in a torus and include the torus opening angle as a free parameter and aim to determine the covering factor of the CT gas in these sources individually. Across the sample we find mild to heavy CT columns, with NH measured from 1024 to 1026 cm-2, and a wide range of covering factors, where individual measurements range from 0.2 to 0.9. We find that the covering factor, fc, is a strongly decreasing function of the intrinsic 2-10 keV luminosity, LX, where fc = (-0.41 ± 0.13)log10(LX/erg s-1)+18.31 ± 5.33, across more than two orders of magnitude in LX (1041.5-1044 erg s-1). The covering factors measured here agree well with the obscured fraction as a function of LX as determined by studies of local AGNs with LX > 1042.5 erg s-1.

  1. 21 CFR 315.3 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 5 2011-04-01 2011-04-01 false General factors relevant to safety and effectiveness. 315.3 Section 315.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE DIAGNOSTIC RADIOPHARMACEUTICALS § 315.3 General factors...

  2. 21 CFR 601.32 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false General factors relevant to safety and effectiveness. 601.32 Section 601.32 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS LICENSING Diagnostic Radiopharmaceuticals § 601.32 General factors...

  3. 21 CFR 315.3 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false General factors relevant to safety and effectiveness. 315.3 Section 315.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE DIAGNOSTIC RADIOPHARMACEUTICALS § 315.3 General factors...

  4. Determining the Covering Factor of Compton-Thick Active Galactic Nuclei with NuSTAR

    NASA Technical Reports Server (NTRS)

    Brightman, M.; Balokovic, M.; Stern, D.; Arevalo, P.; Ballantyne, D. R.; Bauer, F. E.; Boggs, S. E.; Craig, W. W.; Christensen, F. E.; Zhang, W. W.

    2015-01-01

    The covering factor of Compton-thick (CT) obscuring material associated with the torus in active galactic nuclei (AGNs) is at present best understood through the fraction of sources exhibiting CT absorption along the line of sight (N(sub H) greater than 1.5 x 10(exp 24) cm(exp -2)) in the X-ray band, which reveals the average covering factor. Determining this CT fraction is difficult, however, due to the extreme obscuration. With its spectral coverage at hard X-rays (greater than 10 keV), Nuclear Spectroscopic Telescope Array (NuSTAR) is sensitive to the AGNs covering factor since Compton scattering of X-rays off optically thick material dominates at these energies. We present a spectral analysis of 10 AGNs observed with NuSTAR where the obscuring medium is optically thick to Compton scattering, so-called CT AGNs. We use the torus models of Brightman and Nandra that predict the X-ray spectrum from reprocessing in a torus and include the torus opening angle as a free parameter and aim to determine the covering factor of the CT gas in these sources individually. Across the sample we find mild to heavy CT columns, with N(sub H) measured from 10(exp 24) to 10(exp 26) cm(exp -2), and a wide range of covering factors, where individual measurements range from 0.2 to 0.9. We find that the covering factor, f(sub c), is a strongly decreasing function of the intrinsic 2-10 keV luminosity, L(sub X), where f(sub c) = (-0.41 +/- 0.13)log(sub 10)(L(sub X)/erg s(exp -1))+18.31 +/- 5.33, across more than two orders of magnitude in L(sub X) (10(exp 41.5) - 10(exp 44) erg s(exp -1)). The covering factors measured here agree well with the obscured fraction as a function of LX as determined by studies of local AGNs with L(sub X) greater than 10(exp 42.5) erg s(exp -1).

  5. Multiple Landscape Factors Affect the Resilience of a Mixed Land Cover Watershed

    NASA Astrophysics Data System (ADS)

    Golden, H. E.; Lane, C.; Prues, A. G.; D'Amico, E.

    2015-12-01

    Human activities can stimulate the physical and chemical properties of streams to move beyond their background conditions, thereby facilitating the transition of these factors to stressors that affect watershed resilience. This is particularly true in mixed land cover watersheds. We quantify and explore the statistical nonlinear relationships between watershed and buffer-scale factors and nutrient (nitrite-nitrate (NO2-NO3), total Kjeldahl nitrogen (TKN), total phosphorus (TP)) concentrations, in addition to a multi-metric Index of Biotic Integrity (IBI), in a mesoscale mixed land cover watershed. Our goal is to contribute to a better understanding of the potentially numerous landscape and near-stream hydrological and biogeochemical factors that affect watershed resiliency - as inferred from in-stream nutrient levels and biological condition. We used a boosted regression tree approach, which quantifies nonlinear relationships and variable interactions, to develop watershed and 200 m buffer scale models for each chemical constituent and the annual IBI score. We developed nutrient models for the spring and summer seasons. Two primary factors - location within the watershed and percentage of urban land cover in the watershed or buffer - emerged as important explanatory variables in most nutrient and IBI models. Geographic location (i.e., latitude and longitude) interacted with other factors to explain the variability in summer NO2-NO3 concentrations and IBI scores and suggested that location might be associated with indicators of sources (e.g., land cover) and runoff potential (e.g., soil and topographic factors). Runoff indicators (e.g., Hydrologic Soil Group D and Topographic Wetness Indices) explained a substantial portion of the variability in nutrient concentrations as did point sources for TP in the summer months. Our overall approach confirms that it is important to consider multiple and often interacting factors when managing for watershed resilience.

  6. 21 CFR 601.32 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true General factors relevant to safety and effectiveness. 601.32 Section 601.32 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... estimated absorbed radiation dose of the diagnostic radiopharmaceutical....

  7. 21 CFR 315.3 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... SERVICES (CONTINUED) DRUGS FOR HUMAN USE DIAGNOSTIC RADIOPHARMACEUTICALS § 315.3 General factors relevant to safety and effectiveness. FDA's determination of the safety and effectiveness of a diagnostic radiopharmaceutical includes consideration of the following: (a) The proposed use of the...

  8. 21 CFR 315.3 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... SERVICES (CONTINUED) DRUGS FOR HUMAN USE DIAGNOSTIC RADIOPHARMACEUTICALS § 315.3 General factors relevant to safety and effectiveness. FDA's determination of the safety and effectiveness of a diagnostic radiopharmaceutical includes consideration of the following: (a) The proposed use of the...

  9. X-Ray Absorption, Nuclear Infrared Emission, and Dust Covering Factors of AGNs: Testing Unification Schemes

    NASA Astrophysics Data System (ADS)

    Mateos, S.; Carrera, F. J.; Alonso-Herrero, A.; Hernán-Caballero, A.; Barcons, X.; Asensio Ramos, A.; Watson, M. G.; Blain, A.; Caccianiga, A.; Ballo, L.; Braito, V.; Ramos Almeida, C.

    2016-03-01

    We present the distributions of the geometrical covering factors of the dusty tori (f2) of active galactic nuclei (AGNs) using an X-ray selected complete sample of 227 AGNs drawn from the Bright Ultra-hard XMM-Newton Survey. The AGNs have z from 0.05 to 1.7, 2-10 keV luminosities between 1042 and 1046 erg s-1, and Compton-thin X-ray absorption. Employing data from UKIDSS, 2MASS, and the Wide-field Infrared Survey Explorer in a previous work, we determined the rest-frame 1-20 μm continuum emission from the torus, which we model here with the clumpy torus models of Nenkova et al. Optically classified type 1 and type 2 AGNs are intrinsically different, with type 2 AGNs having, on average, tori with higher f2 than type 1 AGNs. Nevertheless, ˜20% of type 1 AGNs have tori with large covering factors, while ˜23%-28% of type 2 AGNs have tori with small covering factors. Low f2 are preferred at high AGN luminosities, as postulated by simple receding torus models, although for type 2 AGNs the effect is certainly small. f2 increases with the X-ray column density, which implies that dust extinction and X-ray absorption take place in material that share an overall geometry and most likely belong to the same structure, the putative torus. Based on our results, the viewing angle, AGN luminosity, and also f2 determine the optical appearance of an AGN and control the shape of the rest-frame ˜1-20 μm nuclear continuum emission. Thus, the torus geometrical covering factor is a key ingredient of unification schemes.

  10. Molecular and microstructural factors affecting mechanical properties of polymeric cover plate materials

    SciTech Connect

    Clark, E.J.

    1985-07-01

    This paper reviews the dependence of mechanical properties of polymers on various microstructural factors. The microstructural and molecular factors considered are: molecular weight, crystallinity, crosslinking, branching, copolymerization, plasticization, orientation, and residual stresses. The types of mechanical properties considered are: direct loading, fatigue, creep, wear and abrasion, and environmental stress cracking. The effects of polymer deformation and fraction at the molecular level are discussed. Cracking, crazing, and shear yielding are described. Polymeric cover plate materials are discussed and their degradation reviewed. Methods to measure microlevel changes in polymers are identified.

  11. Methane oxidation potential of boreal landfill cover materials: The governing factors and enhancement by nutrient manipulation.

    PubMed

    Maanoja, Susanna T; Rintala, Jukka A

    2015-12-01

    Methanotrophs inhabiting landfill covers are in a crucial role in mitigating CH4 emissions, but the characteristics of the cover material or ambient temperature do not always enable the maximal CH4 oxidation potential (MOP). This study aimed at identifying the factors governing MOPs of different materials used for constructing biocovers and other cover structures. We also tested whether the activity of methanotrophs could be enhanced at cold temperature (4 and 12°C) by improving the nutrient content (NO3(-), PO4(3-), trace elements) of the cover material. Compost samples from biocovers designed to support CH4 oxidation were exhibiting the highest MOPs (4.16 μmol CH4 g dw(-1) h(-1)), but also the soil samples collected from other cover structures were oxidising CH4 (0.41 μmol CH4 g dw(-1) h(-1)). The best predictors for the MOPs were the NO3(-) content and activity of heterotrophic bacteria at 72.8%, which were higher in the compost samples than in the soil samples. The depletion of NO3(-) from the landfill cover material limiting the activity of methanotrophs could not be confirmed by the nutrient manipulation assay at 4°C as the addition of nitrogen decreased the MOPs from 0.090 μmol CH4 g dw(-1) h(-1) to <0.085 μmol CH4 g dw(-1) h(-1). At 12°C, all nutrient additions reduced the MOPs. The inhibition was believed to result from high ionic concentration caused by nutrient addition. At 4°C, the addition of trace elements increased the MOPs (>0.096 μmol CH4 g dw(-1)h(-1)) suggesting that this was attributable to stimulation of the enzymatic activity of the psychrotolerant methanotrophs. PMID:26298483

  12. Relevance of social and behavioral factors in the evaluation of dental health care for school children.

    PubMed

    Hamp, S E; Nilsson, T; Faresjö, T; Gamsäter, G

    1984-04-01

    An interdisciplinary strategy based on a theoretical model for studying dental health was used to analyze the relevance of social and behavioral factors in the evaluation of dental health care for school children. The study comprised pupils who, after a total period of 5 years, differed in their experience with preventive regimens applying different principles of dental prevention. In 1979-80 social and behavioral data were collected by means of a postal questionnaire from altogether 234 pupils, aged 15-16 years, from two school areas. Clinical data, comprising scores for prevalence of plaque, gingivitis, and caries, were available from examinations in 1974, 1978, and 1979. The analysis of factors influencing the subjects' oral status demonstrated that material factors--the parents' education and employment, type of housing, and line of education--and physical factors--sex and prevalence of plaque, gingivitis, and caries at base line--all were of significance for the results obtained. No significant influence of home care climate (social/political factors), dental knowledge and attitudes, general foresightedness or carelessness (mental factors), or tooth-cleaning and sweet-eating habits (action factors) was found. Social and behavioral factors of significance exerted their influence regardless of the type and scope of the dental health care provided. Gingival health was far more a consequence of the professional tooth-cleaning regimen than dependent on the social and behavioral factors tested. No superior effect on caries status was demonstrated for any of the preventive regimens tested. PMID:6588720

  13. Observations of fair-weather cumuli over land: Dynamical factors controlling cloud size and cover

    NASA Astrophysics Data System (ADS)

    Lamer, Katia; Kollias, Pavlos

    2015-10-01

    Comprehensive observations of shallow convection at the Atmospheric Radiation Measurement Southern Great Plains site are carefully analyzed to study the macrophysical and dynamical properties of active and forced cumuli separately and investigate their relationship to the subcloud layer turbulent structure. Clearly, active clouds possess stronger dynamics and greater horizontal extent than their forced counterpart. As previously reported, upper level stability and relative humidity do control the predominance of active clouds. While cloud cover remains difficult to associate to mixed-layer parameters (small correlation coefficients), mixed-layer top vertical velocity skewness, and coherent updraft fraction most significantly correlate to cumulus cloud cover and especially the portion attributed to active clouds; both of which are not currently considered in shallow cloudiness parameterizations. This study also points to several factors that continue to limit our ability to adequately sample shallow cumuli and suggests that forward models will be necessary to bridge observations and model outputs.

  14. Relevant factors to consider prior to an investor-owned acquisition of a nonprofit healthcare entity.

    PubMed

    Ault, Kelvin; Childs, Brad; Wainright, Charles F; Young, Marilyn

    2011-01-01

    The purpose of this article is to explore the factors that affect the negotiations for an acquisition of a nonprofit system by an investor-owned entity. The recent economic downturn, accompanying credit crisis, and healthcare reform legislation will likely encourage and accelerate the pace of merger and acquisition (M&A) transactions between investor-owned entities and nonprofit hospitals. As many nonprofits are smaller, more financially vulnerable, and more limited in their access to capital than their investor-owned counterparts, nonprofits could be prime targets for investor-owned acquirers during the healthcare reform implementation period. In M&A transactions of this type, the investor-owned acquirer typically is motivated to pursue an acquisition when the deal promises an acceptable return on investment and decreased operating costs from economies of scale. Alternatively, the nonprofit target is typically seeking funding for upgrades to facilities and information technology systems as well as a continued commitment to charity care and managed-care contracting leverage. A successful acquisition of a nonprofit hospital by an investor-owned company requires a careful analysis of relevant tax, economic, and strategic factors prior to closing the deal. This article lists the most significant factors to consider in these deals and explains how these factors should influence the purchase price and postacquisition cash flow. PMID:21838025

  15. Dust covering factor, silicate emission, and star formation in luminous QSOs

    NASA Astrophysics Data System (ADS)

    Maiolino, R.; Shemmer, O.; Imanishi, M.; Netzer, H.; Oliva, E.; Lutz, D.; Sturm, E.

    2007-06-01

    We present Spitzer IRS low resolution, mid-IR spectra of a sample of 25 high luminosity QSOs at 2covering factor of the circumnuclear dust as a function of luminosity. Such a result is in agreement with the decreasing fraction of absorbed AGNs as a function of luminosity recently found in various surveys. In particular, while X-ray surveys find a decreasing covering factor of the absorbing gas as a function of luminosity, our data provides an independent and complementary confirmation by finding a decreasing covering factor of dust. We clearly detect the silicate emission feature in the average spectrum, but also in four individual objects. These are the silicate emission in the most luminous objects obtained so far. When combined with the silicate emission observed in local, low luminosity type-I AGNs, we find that the silicate emission strength is correlated with luminosity. The silicate strength of all type-I AGNs also follows a positive correlation with the black hole mass and with the accretion rate. The Polycyclic Aromatic Hydrocarbon (PAH) emission features, expected from starburst activity, are not detected in the average spectrum of luminous, high-z QSOs. The upper limit inferred from the average spectrum points to a ratio between PAH luminosity and QSO optical luminosity significantly lower than observed in lower luminosity AGNs, implying that the correlation between star formation rate and AGN power saturates at high luminosities.

  16. Relevant Obstetric Factors for Cerebral Palsy: From the Nationwide Obstetric Compensation System in Japan

    PubMed Central

    Hasegawa, Junichi; Toyokawa, Satoshi; Ikenoue, Tsuyomu; Asano, Yuri; Satoh, Shoji; Ikeda, Tomoaki; Ichizuka, Kiyotake; Tamiya, Nanako; Nakai, Akihito; Fujimori, Keiya; Maeda, Tsugio; Masuzaki, Hideaki; Suzuki, Hideaki; Ueda, Shigeru

    2016-01-01

    Objective The aim of this study was to identify the relevant obstetric factors for cerebral palsy (CP) after 33 weeks’ gestation in Japan. Study design This retrospective case cohort study (1:100 cases and controls) used a Japanese national CP registry. Obstetric characteristics and clinical course were compared between CP cases in the Japan Obstetric Compensation System for Cerebral Palsy database and controls in the perinatal database of the Japan Society of Obstetrics and Gynecology born as live singleton infants between 2009 and 2011 with a birth weight ≥ 2,000 g and gestation ≥ 33 weeks. Results One hundred and seventy-five CP cases and 17,475 controls were assessed. Major relevant single factors for CP were placental abnormalities (31%), umbilical cord abnormalities (15%), maternal complications (10%), and neonatal complications (1%). A multivariate regression model demonstrated that obstetric variables associated with CP were acute delivery due to non-reassuring fetal status (relative risk [RR]: 37.182, 95% confidence interval [CI]: 20.028–69.032), uterine rupture (RR: 24.770, 95% CI: 6.006–102.160), placental abruption (RR: 20.891, 95% CI: 11.817–36.934), and preterm labor (RR: 3.153, 95% CI: 2.024–4.911), whereas protective factors were head presentation (RR: 0.199, 95% CI: 0.088–0.450) and elective cesarean section (RR: 0.236, 95% CI: 0.067–0.828). Conclusion CP after 33 weeks’ gestation in the recently reported cases in Japan was strongly associated with acute delivery due to non-reassuring fetal status, uterine rupture, and placental abruption. PMID:26821386

  17. Therapy-relevant factors in adult ADHD from a cognitive behavioural perspective.

    PubMed

    Newark, Patricia Elizabeth; Stieglitz, Rolf-Dieter

    2010-06-01

    Adult individuals with attention-deficit hyperactivity disorder (ADHD) have been suffering from this neurobiological and highly heritable disorder chronically since childhood. Resulting from their longstanding neuropsychological impairments, such as attentional problems, emotional instability, and disinhibition, they are familiar to a multiplicity of negative life outcomes and underachievement. Furthermore, a large part of this population suffers from psychiatric comorbidity. This accumulation of negative experiences has an impact on therapy-relevant factors such as the individual's self-esteem, self-efficacy, development of core beliefs/schemas, and coping strategies. Based on negative beliefs about the self, individuals confronted with difficult situations develop maladaptive coping strategies, for instance avoidance and procrastination. These strategies lead to maintenance and reinforcement of maladaptive beliefs, and as such they acquit themselves as schema-confirming. Captured in this vicious cycle, the individual sees her negative view of the self confirmed. The purpose of this paper is to illuminate these interactive factors that influence the aforementioned cycle in order to emphasize the cognitive behavioural interventions tailored to those factors on the basis of latest research. Furthermore, the authors want to attract notice to the resources people with ADHD are said to have, namely creativity and resilience. These postulated resources could be therapy-relevant by creating positive beliefs about the self, hence improving coping skills and breaking the vicious circle of negative appraisal. Taking into account personal resources and their fostering may be an important fundament for the treatment plan of adult ADHD. Information on the current state of research and theoretical approaches concerning the below-mentioned key words was gathered through MEDLINE, PsycINFO, PSYNDEXplus, and PubMed databases. PMID:21432591

  18. Complement Factor B Mutations in Atypical Hemolytic Uremic Syndrome—Disease-Relevant or Benign?

    PubMed Central

    Marinozzi, Maria Chiara; Vergoz, Laura; Rybkine, Tania; Ngo, Stephanie; Bettoni, Serena; Pashov, Anastas; Cayla, Mathieu; Tabarin, Fanny; Jablonski, Mathieu; Hue, Christophe; Smith, Richard J.; Noris, Marina; Halbwachs-Mecarelli, Lise; Donadelli, Roberta; Fremeaux-Bacchi, Veronique

    2014-01-01

    Atypical hemolytic uremic syndrome (aHUS) is a genetic ultrarare renal disease associated with overactivation of the alternative pathway of complement. Four gain-of-function mutations that form a hyperactive or deregulated C3 convertase have been identified in Factor B (FB) ligand binding sites. Here, we studied the functional consequences of 10 FB genetic changes recently identified from different aHUS cohorts. Using several tests for alternative C3 and C5 convertase formation and regulation, we identified two gain-of-function and potentially disease-relevant mutations that formed either an overactive convertase (M433I) or a convertase resistant to decay by FH (K298Q). One mutation (R178Q) produced a partially cleaved protein with no ligand binding or functional activity. Seven genetic changes led to near-normal or only slightly reduced ligand binding and functional activity compared with the most common polymorphism at position 7, R7. Notably, none of the algorithms used to predict the disease relevance of FB mutations agreed completely with the experimental data, suggesting that in silico approaches should be undertaken with caution. These data, combined with previously published results, suggest that 9 of 15 FB genetic changes identified in patients with aHUS are unrelated to disease pathogenesis. This study highlights that functional assessment of identified nucleotide changes in FB is mandatory to confirm disease association. PMID:24652797

  19. Persistence and Adherence With Dementia Pharmacotherapy: Relevance of Patient, Provider, and System Factors

    PubMed Central

    Maxwell, Colleen J; Stock, Kathryn; Seitz, Dallas; Herrmann, Nathan

    2014-01-01

    This paper provides a comprehensive review of studies examining adherence and (or) persistence with dementia pharmacotherapy during the past decade, including a summary of the key patient-, drug-, system-, and provider-level factors associated with these measures. Estimates of adherence and 1-year persistence to these drugs have ranged from 34% to 94% and 35% to 60%, respectively. Though many studies reported nonsignificant associations, there are data suggesting that patient age, sex, ethnoracial background, socioeconomic status, and region-specific reimbursement criteria, as well as the extent and quality of interactions among patients, caregivers, and providers, may influence persistence with pharmacotherapy. As many studies relied on administrative data, limited information was available regarding the relevance of patient’s cognitive and functional status or the importance of caregiver involvement or assistive devices to adherence or persistence. PMID:25702361

  20. Microbial Relevant Fouling in Membrane Bioreactors: Influencing Factors, Characterization, and Fouling Control

    PubMed Central

    Wu, Bing; Fane, Anthony G.

    2012-01-01

    Microorganisms in membrane bioreactors (MBRs) play important roles on degradation of organic/inorganic substances in wastewaters, while microbial deposition/growth and microbial product accumulation on membranes potentially induce membrane fouling. Generally, there is a need to characterize membrane foulants and to determine their relations to the evolution of membrane fouling in order to identify a suitable fouling control approach in MBRs. This review summarized the factors in MBRs that influence microbial behaviors (community compositions, physical properties, and microbial products). The state-of-the-art techniques to characterize biofoulants in MBRs were reported. The strategies for controlling microbial relevant fouling were discussed and the future studies on membrane fouling mechanisms in MBRs were proposed. PMID:24958297

  1. Clinical relevance of and risk factors for HSV-related tracheobronchitis or pneumonia: results of an outbreak investigation

    PubMed Central

    Engelmann, Ilka; Gottlieb, Jens; Meier, Astrid; Sohr, Dorit; Ruhparwar, Arjang; Henke-Gendo, Cornelia; Gastmeier, Petra; Welte, Tobias; Schulz, Thomas Friedrich; Mattner, Frauke

    2007-01-01

    Introduction Herpes simplex virus (HSV) type 1 was identified in respiratory specimens from a cluster of eight patients on a surgical intensive care unit within 8 weeks. Six of these patients suffered from HSV-related tracheobronchitis and one from HSV-related pneumonia only. Our outbreak investigation aimed to determine the clinical relevance of and risk factors associated with HSV-related tracheobronchitis or pneumonia in critically ill patients, and to investigate whether the cluster was caused by nosocomial transmission. Methods A retrospective cohort study was performed to identify risk factors for the outcomes of HSV-related tracheobronchitis or pneumonia and death using univariable analysis as well as logistic regression analysis. Viruses were typed by molecular analysis of a fragment of the HSV type 1 glycoprotein G. Results The cohort of patients covering the outbreak period comprised 53 patients, including six patients with HSV-related tracheobronchitis and one patient with pneumonia only. HSV-related tracheobronchitis or pneumonia was associated with increased mortality (100% in patients with versus 17.8% in patients without HSV-related tracheobronchitis or pneumonia; P < 0.0001). The interaction of longer duration of ventilation and tracheotomy was associated with HSV-related tracheobronchitis or pneumonia in multivariable analysis. Identical HSV type 1 glycoprotein G sequences were found in three patients and in two patients. The group of three identical viral sequences belonged to a widely circulating strain. The two identical viral sequences were recovered from bronchoalveolar lavages of one patient with HSV-related tracheobronchitis and of one patient without clinical symptoms. These viral sequences showed unique polymorphisms, indicating probable nosocomial transmission. Conclusion HSV-related tracheobronchitis or pneumonia is associated with increased mortality in critically ill patients. Care should be taken to avoid nosocomial transmission and

  2. Expression, regulation and clinical relevance of the ATPase inhibitory factor 1 in human cancers

    PubMed Central

    Sánchez-Aragó, M; Formentini, L; Martínez-Reyes, I; García-Bermudez, J; Santacatterina, F; Sánchez-Cenizo, L; Willers, I M; Aldea, M; Nájera, L; Juarránz, Á; López, E C; Clofent, J; Navarro, C; Espinosa, E; Cuezva, J M

    2013-01-01

    Recent findings in colon cancer cells indicate that inhibition of the mitochondrial H+-adenosine triphosphate (ATP) synthase by the ATPase inhibitory factor 1 (IF1) promotes aerobic glycolysis and a reactive oxygen species (ROS)-mediated signal that enhances proliferation and cell survival. Herein, we have studied the expression, biological relevance, mechanism of regulation and potential clinical impact of IF1 in some prevalent human carcinomas. We show that IF1 is highly overexpressed in most (>90%) of the colon (n=64), lung (n=30), breast (n=129) and ovarian (n=10) carcinomas studied as assessed by different approaches in independent cohorts of cancer patients. The expression of IF1 in the corresponding normal tissues is negligible. By contrast, the endometrium, stomach and kidney show high expression of IF1 in the normal tissue revealing subtle differences by carcinogenesis. The overexpression of IF1 also promotes the activation of aerobic glycolysis and a concurrent ROS signal in mitochondria of the lung, breast and ovarian cancer cells mimicking the activity of oligomycin. IF1-mediated ROS signaling activates cell-type specific adaptive responses aimed at preventing death in these cell lines. Remarkably, regulation of IF1 expression in the colon, lung, breast and ovarian carcinomas is exerted at post-transcriptional levels. We demonstrate that IF1 is a short-lived protein (t1/2 ∼100 min) strongly implicating translation and/or protein stabilization as main drivers of metabolic reprogramming and cell survival in these human cancers. Analysis of tumor expression of IF1 in cohorts of breast and colon cancer patients revealed its relevance as a predictive marker for clinical outcome, emphasizing the high potential of IF1 as therapeutic target. PMID:23608753

  3. Analysis of Clinically Relevant Factors for Pulmonary Hypertension in Maintenance Hemodialysis Patients

    PubMed Central

    Shen, Shen; Sun, Qianmei

    2015-01-01

    Background Pulmonary hypertension (PH) is common in patients with maintenance hemodialysis (MHD) and is associated with high mortality. This study analyzed clinically relevant factors for pulmonary hypertension in MHD patients and the effect of serum pentraxin3 (PTX3) in the pathogenesis of PH to provide the basis for early diagnosis and treatment of MHD patients with PH. Material/Methods This study included 60 MHD patients (group A) and 30 healthy controls (group B). Group A was further divided into PH and non-PH groups. Clinical characteristics, auxiliary examination results and serum PTX3 level of the PH and non-PH groups were compared. Binary logistic regression was used to assess the risk factors for PH in MHD patients. ROC curve was applied to evaluate the diagnostic value of PTX3 in PH. Results The incidence rate of PH in MHD patients was 50%, and most presented as mild to moderate. Compared with the non-PH group, patients in PH group presented significantly longer atrial diameter, right ventricular diameter and main pulmonary artery diameter (P<0.05), as well as higher PTX3 and NT-proBNP level. Atrial diameter and PTX3 level were the risk factors for PH in MHD patients. AUC of PTX3 was 0.721 (95%CI: 0.590–0.851, P=0.003). Conclusions The prevalence of PH was higher in MHD patients and mostly presented as mild to moderate. Such patients often developed heart structural changes and cardiac ultrasound was highly recommended. Serum PTX3 level was significantly elevated and could be used as a marker of PH in MHD patients. PMID:26706606

  4. Analysis of Clinically Relevant Factors for Pulmonary Hypertension in Maintenance Hemodialysis Patients.

    PubMed

    Shen, Shen; Sun, Qianmei

    2015-01-01

    BACKGROUND Pulmonary hypertension (PH) is common in patients with maintenance hemodialysis (MHD) and is associated with high mortality. This study analyzed clinically relevant factors for pulmonary hypertension in MHD patients and the effect of serum pentraxin3 (PTX3) in the pathogenesis of PH to provide the basis for early diagnosis and treatment of MHD patients with PH. MATERIAL AND METHODS This study included 60 MHD patients (group A) and 30 healthy controls (group B). Group A was further divided into PH and non-PH groups. Clinical characteristics, auxiliary examination results and serum PTX3 level of the PH and non-PH groups were compared. Binary logistic regression was used to assess the risk factors for PH in MHD patients. ROC curve was applied to evaluate the diagnostic value of PTX3 in PH. RESULTS The incidence rate of PH in MHD patients was 50%, and most presented as mild to moderate. Compared with the non-PH group, patients in PH group presented significantly longer atrial diameter, right ventricular diameter and main pulmonary artery diameter (P<0.05), as well as higher PTX3 and NT-proBNP level. Atrial diameter and PTX3 level were the risk factors for PH in MHD patients. AUC of PTX3 was 0.721 (95%CI: 0.590-0.851, P=0.003). CONCLUSIONS The prevalence of PH was higher in MHD patients and mostly presented as mild to moderate. Such patients often developed heart structural changes and cardiac ultrasound was highly recommended. Serum PTX3 level was significantly elevated and could be used as a marker of PH in MHD patients. PMID:26706606

  5. Prognostic Factors Toward Clinically Relevant Radiographic Progression in Patients With Rheumatoid Arthritis in Clinical Practice

    PubMed Central

    Koga, Tomohiro; Okada, Akitomo; Fukuda, Takaaki; Hidaka, Toshihiko; Ishii, Tomonori; Ueki, Yukitaka; Kodera, Takao; Nakashima, Munetoshi; Takahashi, Yuichi; Honda, Seiyo; Horai, Yoshiro; Watanabe, Ryu; Okuno, Hiroshi; Aramaki, Toshiyuki; Izumiyama, Tomomasa; Takai, Osamu; Miyashita, Taiichiro; Sato, Shuntaro; Kawashiri, Shin-ya; Iwamoto, Naoki; Ichinose, Kunihiro; Tamai, Mami; Origuchi, Tomoki; Nakamura, Hideki; Aoyagi, Kiyoshi; Eguchi, Katsumi; Kawakami, Atsushi

    2016-01-01

    Abstract To determine prognostic factors of clinically relevant radiographic progression (CRRP) in patients with rheumatoid arthritis (RA) in clinical practice. We performed a multicenter prospective study in Japan of biological disease-modifying antirheumatic drug (bDMARD)-naive RA patients with moderate to high disease activity treated with conventional synthetic DMARDs (csDMARDs) at study entry. We longitudinally observed 408 patients for 1 year and assessed disease activity every 3 months. CRRP was defined as yearly progression of modified total Sharp score (mTSS) > 3.0 U. We also divided the cohort into 2 groups based on disease duration (<3 vs ≥3 years) and performed a subgroup analysis. CRRP was found in 10.3% of the patients. A multiple logistic regression analysis revealed that the independent variables to predict the development of CRRP were: CRP at baseline (0.30 mg/dL increase, 95% confidence interval [CI] 1.01–1.11), time-integrated Disease Activity Score in 28 joints-erythrocyte sedimentation rate (DAS28-ESR) during the 1 year postbaseline (12.4-unit increase, 95%CI 1.17–2.59), RA typical erosion at baseline (95%CI 1.56–21.1), and the introduction of bDMARDs (95%CI 0.06–0.38). The subgroup analysis revealed that time-integrated DAS28-ESR is not a predictor whereas the introduction of bDMARDs is a significant protective factor for CRRP in RA patients with disease duration <3 years. We identified factors that could be used to predict the development of CRRP in RA patients treated with DMARDs. These variables appear to be different based on the RA patients’ disease durations. PMID:27124044

  6. The relevance of coagulation factor X protection of adenoviruses in human sera

    PubMed Central

    Duffy, M R; Doszpoly, A; Turner, G; Nicklin, S A; Baker, A H

    2016-01-01

    Intravenous delivery of adenoviruses is the optimal route for many gene therapy applications. Once in the blood, coagulation factor X (FX) binds to the adenovirus capsid and protects the virion from natural antibody and classical complement-mediated neutralisation in mice. However, to date, no studies have examined the relevance of this FX/viral immune protective mechanism in human samples. In this study, we assessed the effects of blocking FX on adenovirus type 5 (Ad5) activity in the presence of human serum. FX prevented human IgM binding directly to the virus. In individual human sera samples (n=25), approximately half of those screened inhibited adenovirus transduction only when the Ad5–FX interaction was blocked, demonstrating that FX protected the virus from neutralising components in a large proportion of human sera. In contrast, the remainder of sera tested had no inhibitory effects on Ad5 transduction and FX armament was not required for effective gene transfer. In human sera in which FX had a protective role, Ad5 induced lower levels of complement activation in the presence of FX. We therefore demonstrate for the first time the importance of Ad–FX protection in human samples and highlight subject variability and species-specific differences as key considerations for adenoviral gene therapy. PMID:27014840

  7. Allergic contact dermatitis in children: which factors are relevant? (review of the literature).

    PubMed

    de Waard-van der Spek, Flora B; Andersen, Klaus E; Darsow, Ulf; Mortz, Charlotte G; Orton, David; Worm, Margitta; Muraro, Antonella; Schmid-Grendelmeier, Peter; Grimalt, Ramon; Spiewak, Radoslaw; Rudzeviciene, Odilija; Flohr, Carsten; Halken, Susanne; Fiocchi, Alessandro; Borrego, Luis M; Oranje, Arnold P

    2013-06-01

    Allergic contact dermatitis (ACD) in children is increasing. Sensitization to contact allergens can start in early infancy. The epidermal barrier is crucial for the development of sensitization and elicitation of ACD. Factors that may influence the onset of sensitization in children are atopic dermatitis, skin barrier defects and intense or repetitive contact with allergens. Topical treatment of ACD is associated with cutaneous sensitization, although the prevalence is not high. ACD because of haptens in shoes or shin guards should be considered in cases of persistent foot eruptions or sharply defined dermatitis on the lower legs. Clinical polymorphism of contact dermatitis to clothing may cause difficulties in diagnosing textile dermatitis. Toys are another potentially source of hapten exposure in children, especially from toy-cosmetic products such as perfumes, lipstick and eye shadow. The most frequent contact allergens in children are metals, fragrances, preservatives, neomycin, rubber chemicals and more recently also colourings. It is very important to remember that ACD in young children is not rare, and should always be considered when children with recalcitrant eczema are encountered. Children should be patch-tested with a selection of allergens having the highest proportion of positive, relevant patch test reactions. The allergen exposure pattern differs between age groups and adolescents may also be exposed to occupational allergens. The purpose of this review is to alert the paediatrician and dermatologist of the frequency of ACD in young children and of the importance of performing patch tests in every case of chronic recurrent or therapy-resistant eczema in children. PMID:23373713

  8. Track way distance and cover as risk factors for lameness in Danish dairy cows.

    PubMed

    Burow, E; Thomsen, P T; Rousing, T; Sørensen, J T

    2014-03-01

    This study investigates the effect of length and cover of track ways between barn and pasture on lameness in Danish dairy cows. We hypothesised that short track distances would be associated with a lower lameness probability of dairy cows compared to longer distances and that track ways with prepared cover (asphalt, gravel, slag, concrete, rubber) compared to no prepared cover (sand, soil and/or grass) would be associated with a lower lameness probability of dairy cows in grazing herds. In total, 2084 dairy cows from 36 herds, grazing their dairy cows during summer, were individually assessed for their lameness status. The cows were further clinically examined for claw conformation and hock integument. Information on breed and parity per cow and size per herd was extracted from a national data base. Track way distance ranged from 0 to 700 m and was categorised as (1) <165 m or (2) ≥165 m. Cover of track way was categorised as (1) prepared (asphalt, gravel, slag, concrete, and/or rubber), (2) partly prepared or (3) not prepared (soil, sand, grass) for the surface of the majority of tracks used. The effect of track way distance and cover was evaluated for their impact on lameness using logistic analysis with a multi-level model structure. The probability for lameness did not change with track distance but increased with no (odds 4.0 times higher) or only partly prepared (odds 3.8 times higher) cover compared to prepared cover. In conclusion, we found that having a cover on the track way was associated with decreased severe lameness in Danish dairy cows. PMID:24387936

  9. Decoupling factors affecting plant diversity and cover on extensive green roofs.

    PubMed

    MacIvor, J Scott; Margolis, Liat; Puncher, Curtis L; Carver Matthews, Benjamin J

    2013-11-30

    Supplemental irrigation systems are often specified on green roofs to ensure plant cover and growth, both important components of green roof performance and aesthetics. Properties of the growing media environment too can alter the assemblage of plant species able to thrive. In this study we determine how plant cover, above ground biomass and species diversity are influenced by irrigation and growing media. Grass and forb vegetative cover and biomass were significantly greater in organic based growing media but there was no effect of supplemental irrigation, with two warm season grasses dominating in those treatments receiving no supplemental irrigation. On the other hand, plant diversity declined without irrigation in organic media, and having no irrigation in inorganic growing media resulted in almost a complete loss of cover. Sedum biomass was less in inorganic growing media treatments and species dominance shifted when growing media organic content increased. Our results demonstrate that supplemental irrigation is required to maintain plant diversity on an extensive green roof, but not necessarily plant cover or biomass. These results provide evidence that planting extensive green roofs with a mix of plant species can ensure the survival of some species; maintaining cover and biomass when supplemental irrigation is turned off to conserve water, or during extreme drought. PMID:24100190

  10. Ice Cover as a Factor Driving Microbial Community Structure in the Laurentian Great Lakes

    NASA Astrophysics Data System (ADS)

    McKay, R. M.; Beall, B.; Oyserman, B.; Smith, D.; Bullerjahn, G.; Morris, P.; Twiss, M. R.

    2013-12-01

    Lakes serve as rapid responding sentinels of human influence on the natural environment rendering them powerful tools to advance our understanding of a changing climate on microbial community structure and function. Whereas we possess a baseline knowledge of microbial diversity in the Great Lakes, we know little about how these communities respond to the manifestations of climate change. Through collaboration with U.S.- and Canadian Coast Guards, winter surveys have been conducted on Lake Erie since 2007. The surveys have captured extremes in ice extent ranging from expansive ice cover through 2011 to nearly ice-free waters in winter 2012, a condition driven by a warm positive Arctic Oscillation. We showed that dramatic changes in annual ice cover were accompanied by equally dramatic shifts in phytoplankton community structure. Expansive ice cover documented for Lake Erie in winters 2010 and 2011 supported ice-associated phytoplankton blooms dominated by physiologically robust, filamentous centric diatoms. Transcriptomic analysis of the winter bloom offers insights into the success of this psychrophilic community. By comparison, ice free conditions promoted the growth of small-sized cells supported by analysis of size-fractionated chlorophyll a and flow cytometry. The phytoplankton community in winter 2013 was dominated by microplankton-sized filamentous diatoms, coincident with expansive ice cover and thus returning to the size structure of the 2010 and 2011 communities. Reduced size is recognized as a universal ecological response to global warming in aquatic systems although it usually marks a response to climate warming over multiple years, not a single season as reported here. Fig. 1. Winter surveys conducted on Lake Erie over two years demonstrated tight coupling between microplankton Chl a biomass and total Chl a during winter 2010-11 (purple, green), a year of expansive ice cover. A warm positive Arctic Oscillation resulted in negligible ice cover on Lake

  11. The Relevance of Cultural Factors in Predicting Condom-Use Intentions among Immigrants from the Netherlands Antilles

    ERIC Educational Resources Information Center

    Kocken, P. L.; van Dorst, A. G.; Schaalma, H.

    2006-01-01

    A study into the relevance of cultural factors in predicting condom-use intentions among Antillean migrants in the Netherlands is described in this article. The association between the intention to use condoms with a new sexual partner and a perceived taboo on discussing sex, beliefs about sex education and machismo beliefs on gender and power…

  12. Factors that Influence the Perceived Advantages and Relevance of Facebook as a Learning Tool: An Extension of the UTAUT

    ERIC Educational Resources Information Center

    Escobar-Rodríguez, Tomás; Carvajal-Trujillo, Elena; Monge-Lozano, Pedro

    2014-01-01

    Social media technologies are becoming a fundamental component of education. This study extends the Unified Theory of Acceptance and Use of Technology (UTAUT) to identify factors that influence the perceived advantages and relevance of Facebook as a learning tool. The proposed model is based on previous models of UTAUT. Constructs from previous…

  13. Intraepithelial ischemia is a principal factor promoting cancerization of the covering epithelial tissues.

    PubMed

    Karseladze, A I

    2016-09-01

    Prominent angiogenesis, which is a hallmark of invasive cancer is preceded at the precancerous stage by marked ischemia. Our hypothesis proposes a structural mechanism responsible for altering blood flow in the covering epithelium and leading to marked reduction of vascularization in the foci of dysplasia. This mechanism varies from one type of epithelium to another. In squamous epithelium only basal cells are in direct contact with stromal vessels. To supply nutrients to the rest of the cells located at different levels, the subjacent stroma forms excrescences which penetrate upward together with blood capillaries. As soon as precancerous dysplastic alterations start and progress the number of intraepithelial blood vessels simultaneously decreases, thus leading to ischemia which precedes or promotes malignization of the covering squamous epithelium. To compensate for the deficit in blood supply, the dysplastic cells penetrate deeper into the underlying stroma, commencing invasion. Thus, the cells destroy the subjacent stroma not because they are initially "malignant", but due to ischemia which provokes the search for nutrients. Comparing squamous epithelium with glandular respiratory epithelium shows that the latter contains no blood capillaries at all. However, unlike squamous epithelial coverings, in respiratory epithelial covering, each cell is attached directly to the basal membrane and has ample access to the blood supply. Covering respiratory epithelium itself seldom gives rise directly to malignant growth. Cancerization of this type of epithelium occurs in the foci of squamous metaplasia. The latter are not supplied by a sufficient amount of blood vessels and in the majority of cases remain fragile and vulnerable structures, easily prone to malignization. Further study of these phenomenon should include the clarification of the influence of carcinogenic agents on the mechanism of adequate vascularization at the precancerous stage. PMID:27515223

  14. Dynamic of mangrove cover change with anthropogenic factors on small island, Spermonde Archipelago

    NASA Astrophysics Data System (ADS)

    Nurdin, Nurjannah; Akbar, M.; Patittingi, Farida

    2015-10-01

    There is no agreement for the extensive of mangrove forest in Indonesia, but invarious forums it is usually used the number of 4.25 million ha for that. At approximately 9 years ago, the extensive vast of mangrove forest in Indonesia was about 4.13 million ha but now it is only 2.49 million ha (60%). Remote sensing could play an important and effective role in the assessment and monitoring of mangrove forest cover dynamics. The aim of this study is to measure change of the mangrove cover from the 1972 to 1993, from 1993 to 2003, from 2003 to 2013, and from 1972 to 2014 using multitemporal Landsat. The study site was selected in Tanakeke Island, Takalar District, South Sulawesi, Indonesia. The results of analyze shows the mangrove forest is decrease and It is caused anthropogenic impact.

  15. What drives accelerated land cover change in central Argentina? Synergistic consequences of climatic, socioeconomic, and technological factors.

    PubMed

    Zak, Marcelo R; Cabido, Marcelo; Cáceres, Daniel; Díaz, Sandra

    2008-08-01

    Synergistic combinations of climatic and land use changes have the potential to produce the most dramatic impacts on land cover. Although this is widely accepted, empirical examples, particularly involving deforestation in Latin America, are still very few. The geographic extent and causes of deforestation in subtropical seasonally dry forests of the world have received very little attention. This is especially true for the Chaco forests in South America, which are being lost at an alarming rate, sometimes higher than those reported for tropical forests. On this basis, the aims of this study were to analyze the changes in land cover that have occurred during the last three decades of the 20th century in the Chaco forests of central Argentina, and to explain the factors that have driven those changes. Results show major land cover changes. Approximately 80% of the area that was originally undisturbed forest is now occupied by crops, pastures, and secondary scrub. The main proximate cause of deforestation has been agricultural expansion, soybean cultivation in particular. This appears as the result of the synergistic convergence of climatic, technological, and socioeconomic factors, supporting the hypothesis of a multiple-factor explanation for forest loss, while providing one of the very few existing analyses of changes in subtropical forests of the world. PMID:18427886

  16. Malaria entomological risk factors in relation to land cover in the Lower Caura River Basin, Venezuela

    PubMed Central

    Rubio-Palis, Yasmin; Bevilacqua, Mariapia; Medina, Domingo Alberto; Moreno, Jorge Ernesto; Cárdenas, Lya; Sánchez, Víctor; Estrada, Yarys; Anaya, William; Martínez, Ángela

    2013-01-01

    To explore the effects of deforestation and resulting differences in vegetation and land cover on entomological parameters, such as anopheline species composition, abundance, biting rate, parity and entomological inoculation rate (EIR), three villages were selected in the Lower Caura River Basin, state of Bolívar, Venezuela. All-night mosquito collections were conducted between March 2008-January 2009 using CDC light traps and Mosquito Magnet(r) Liberty Plus. Human landing catches were performed between 06:00 pm-10:00 pm, when anophelines were most active. Four types of vegetation were identified. The Annual Parasite Index was not correlated with the type of vegetation. The least abundantly forested village had the highest anopheline abundance, biting rate and species diversity. Anopheles darlingi and Anopheles nuneztovari were the most abundant species and were collected in all three villages. Both species showed unique biting cycles. The more abundantly forested village of El Palmar reported the highest EIR. The results confirmed previous observations that the impacts of deforestation and resulting changes in vegetation cover on malaria transmission are complex and vary locally. PMID:23579803

  17. Malaria entomological risk factors in relation to land cover in the Lower Caura River Basin, Venezuela.

    PubMed

    Rubio-Palis, Yasmin; Bevilacqua, Mariapia; Medina, Domingo Alberto; Moreno, Jorge Ernesto; Cárdenas, Lya; Sánchez, Víctor; Estrada, Yarys; Anaya, William; Martínez, Ángela

    2013-04-01

    To explore the effects of deforestation and resulting differences in vegetation and land cover on entomological parameters, such as anopheline species composition, abundance, biting rate, parity and entomological inoculation rate (EIR), three villages were selected in the Lower Caura River Basin, state of Bolívar, Venezuela. All-night mosquito collections were conducted between March 2008-January 2009 using CDC light traps and Mosquito Magnet® Liberty Plus. Human landing catches were performed between 06:00 pm-10:00 pm, when anophelines were most active. Four types of vegetation were identified. The Annual Parasite Index was not correlated with the type of vegetation. The least abundantly forested village had the highest anopheline abundance, biting rate and species diversity. Anopheles darlingi and Anopheles nuneztovari were the most abundant species and were collected in all three villages. Both species showed unique biting cycles. The more abundantly forested village of El Palmar reported the highest EIR. The results confirmed previous observations that the impacts of deforestation and resulting changes in vegetation cover on malaria transmission are complex and vary locally. PMID:23579803

  18. Positive tropical marine low-cloud cover feedback inferred from cloud-controlling factors

    NASA Astrophysics Data System (ADS)

    Qu, Xin; Hall, Alex; Klein, Stephen A.; DeAngelis, Anthony M.

    2015-09-01

    Differences in simulations of tropical marine low-cloud cover (LCC) feedback are sources of significant spread in temperature responses of climate models to anthropogenic forcing. Here we show that in models the feedback is mainly driven by three large-scale changes—a strengthening tropical inversion, increasing surface latent heat flux, and an increasing vertical moisture gradient. Variations in the LCC response to these changes alone account for most of the spread in model-projected 21st century LCC changes. A methodology is devised to constrain the LCC response observationally using sea surface temperature (SST) as a surrogate for the latent heat flux and moisture gradient. In models where the current climate's LCC sensitivities to inversion strength and SST variations are consistent with observed, LCC decreases systematically, which would increase absorption of solar radiation. These results support a positive LCC feedback. Correcting biases in the sensitivities will be an important step toward more credible simulation of cloud feedbacks.

  19. Neighborhood Factors Relevant for Walking in Older, Urban, African American Adults

    PubMed Central

    Gallagher, Nancy Ambrose; Gretebeck, Kimberlee A.; Robinson, Jennifer C.; Torres, Elisa R.; Murphy, Susan L.; Martyn, Kristy K.

    2010-01-01

    Focus-group and photo-voice methodology were used to identify the salient factors of the neighborhood environment that encourage or discourage walking in older, urban African Americans. Twenty-one male (n = 2) and female (n = 19) African Americans age 60 years and older (M = 70 ± 8.7, range = 61–85) were recruited from a large urban senior center. Photographs taken by the participants were used to facilitate focus-group discussions. The most salient factors that emerged included the presence of other people, neighborhood surroundings, and safety from crime, followed by sidewalk and traffic conditions, animals, public walking tracks and trails, and weather. Future walking interventions for older African Americans should include factors that encourage walking, such as the presence of other friendly or active people, attractive or peaceful surroundings, and a sense of safety from crime. PMID:20181997

  20. On the relevance of assumptions associated with classical factor analytic approaches.

    PubMed

    Kasper, Daniel; Unlü, Ali

    2013-01-01

    A personal trait, for example a person's cognitive ability, represents a theoretical concept postulated to explain behavior. Interesting constructs are latent, that is, they cannot be observed. Latent variable modeling constitutes a methodology to deal with hypothetical constructs. Constructs are modeled as random variables and become components of a statistical model. As random variables, they possess a probability distribution in the population of reference. In applications, this distribution is typically assumed to be the normal distribution. The normality assumption may be reasonable in many cases, but there are situations where it cannot be justified. For example, this is true for criterion-referenced tests or for background characteristics of students in large scale assessment studies. Nevertheless, the normal procedures in combination with the classical factor analytic methods are frequently pursued, despite the effects of violating this "implicit" assumption are not clear in general. In a simulation study, we investigate whether classical factor analytic approaches can be instrumental in estimating the factorial structure and properties of the population distribution of a latent personal trait from educational test data, when violations of classical assumptions as the aforementioned are present. The results indicate that having a latent non-normal distribution clearly affects the estimation of the distribution of the factor scores and properties thereof. Thus, when the population distribution of a personal trait is assumed to be non-symmetric, we recommend avoiding those factor analytic approaches for estimation of a person's factor score, even though the number of extracted factors and the estimated loading matrix may not be strongly affected. An application to the Progress in International Reading Literacy Study (PIRLS) is given. Comments on possible implications for the Programme for International Student Assessment (PISA) complete the presentation. PMID

  1. Environmental factors affecting long-term stabilization of radon suppression covers for uranium mill tailings

    SciTech Connect

    Young, J.K.; Long, L.W.; Reis, J.W.

    1982-04-01

    Pacific Northwest Laboratory is investigating the use of a rock armoring blanket (riprap) to mitigate wind and water erosion of an earthen radon suppression cover applied to uranium mill tailings. To help determine design stresses for the tailings piles, environmental parameters are characterized for the five active uranium-producing regions on a site-specific basis. Only conventional uranium mills that are currently operating or that are scheduled to open in the mid 1980s are considered. Available data indicate that flooding has the most potential for disrupting a tailings pile. The arid regions of the Wyoming Basins and the Colorado Plateau are subject to brief storms of high intensity. The Texas Gulf Coast has the highest potential for extreme precipitation from hurricane-related storms. Wind data indicate average wind speeds from 3 to 6 m/sec for the sites, but extremes of 40 m/sec can be expected. Tornado risks range from low to moderate. The Colorado Plateau has the highest seismic potential, with maximum acceleration caused by earthquakes ranging from 0.2 to 0.4 g. Any direct effect from volcanic eruption is negligible, as all mills are located 90 km or more from an igneous or hydrothermal system.

  2. META-ANALYSIS OF THE LIFE STYLE FACTORS RELEVANT TO ENVIRONMENTAL HAZARDS FOR THE AGING POPULATION

    EPA Science Inventory

    The goal of this U.S. Environmental Protection Agency (EPA) study is to characterize activity patterns, physiological changes, and environmental exposures for the aging population. Meta analysis was performed on more than 2000 reviewed articles to evaluate the lifestyle factors ...

  3. 29 CFR 780.145 - The relationship is determined by consideration of all relevant factors.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... any, of the practice to farming as evidenced by common understanding, competitive factors, and the... UNDER THE FAIR LABOR STANDARDS ACT General Scope of Agriculture Performance of the Practice âas An Incident to Or in Conjunction Withâ the Farming Operations § 780.145 The relationship is determined...

  4. The Assessment of the Likelihood of Mammography Usage with Relevant Factors among Women with Disabilities

    ERIC Educational Resources Information Center

    Kung, Pei-Tseng; Tsai, Wen-Chen; Chiou, Shang-Jyh

    2012-01-01

    Research that identifies the determinants of low mammography use among disabled people is scant. This study examines the determining factors related to the low usage of mammography among women with disabilities. To identify the barriers that prevent women with disabilities from participating in mammography screening can help authorities conceive…

  5. [Distribution of PGEs contents and its factors in snowfall and snow cover over the arid region in Changji City].

    PubMed

    Liu, Yu-Yan; Liu, Hao-Feng; Zhang, Lan

    2013-02-01

    This paper was to select a small-medium sized City, Changji city, over the arid region, study the distribution of platinum group metals(PGEs) contents and influencing factors in snowfall and snow cover. Samples were analysed by ICP-MS. The results revealed that the annual contents of Rh, Pd and Pt in snowfall were on the average value of 0.43 ng.L-1 ranging from not detected to 2.24 ng.L-1 , 60.07 ng.L-1 ranging from 46.66 to 84.25 ng.L-1 and 4.54 ng.L-1 ranging from 3.02 ng.L-1 to 6.38 ng.L-1 respectively. The difference of PGEs levels was found in different occurrences of snowfall, tended to increase before snowfall due to the longer arid days. PGEs contents maybe influenced by the amount of snowfall, the less snowfall, the higher PGEs contents reflected. The annual levels of Rh, Pd and Pt in snow cover were in the range of 2.50-18.80 ng.L-1 (av. 6.65 ng.L-1), 46.83-199.20 ng.L-1 (av. 83.45 ng.L-1) ,4. 27-13.78 ng.L-1 (av. 8.17 ng.L-1) respectively. PGEs content in snow cover were far higher than that of snowfall, PGEs in snowfall were only obtained from atmospheric PGEs rinsed by single time of snowfall, while PGEs were not only from the accumulation of PGEs in frequent times of snowfall and the snow cover under the long time exposure, but also continuously accepted the PGEs from atmospheric dry deposition. PGEs content of snow cover in all sampling sites were demonstrated as follows: traffic area > residential-culture-education district > square of park > suburban farmland. the input way of PGEs in snow cover was found a remarkable difference with the amount of input within different function areas, which was the main reason caused that PGEs content of snow cover in each function area varied and had a certain regularity. PMID:23668114

  6. [Dynamics of recent cultivated land in Zhejiang Province and relevant driving factors].

    PubMed

    Zhang, Hai-dong; Yu, Dong-sheng; Shi, Xue-zheng; Liu, Ying-an; Wang, Shi-hang; Zhang, Guang-xing; Liu, Yang

    2010-12-01

    Through the human-computer interactive interpretation of the 2000, 2005, and 2008 remote sensing images of Zhejiang Province with the help of RS and GIS techniques, the dynamic database of cultivated land change in the province in, 2000-2008 was established, and the driving factors of the cultivated land change were analyzed by ridge regression analysis. There was a notable cultivated land change in the province in 2000-2008. In 2000-2005 and 2005-2008, the annual cultivated land change in the province arrived -1.42% and -1.46%, respectively, and most of the cultivated land was changed into residential and industrial land. Non-agricultural population rate, real estate investment, urban green area, and orchard area were thought to be the main driving factors of the cultivated land change in Zhejiang Province, and even, in the developed areas of east China. PMID:21442998

  7. Mechanistic basis and clinical relevance of the role of transforming growth factor-β in cancer

    PubMed Central

    Lin, Run-Long; Zhao, Lu-Jun

    2015-01-01

    Transforming growth factor-β (TGF-β) is a key factor in cancer development and progression. TGF-β can suppress tumorigenesis by inhibiting cell cycle progression and stimulating apoptosis in early stages of cancer progression. However, TGF-β can modulate cancer-related processes, such as cell invasion, distant metastasis, and microenvironment modification that may be used by cancer cells to their advantage in late stages. Corresponding mechanisms include angiogenesis promotion, anti-tumor immunity suppression, and epithelial-to-mesenchymal transition (EMT) induction. The correlation between TGF-β expression and cancer prognosis has also been extensively investigated. Results suggest that TGF-β pathway can be targeted to treat cancer; as such, the feasibility of this treatment is investigated in clinical trials. PMID:26779375

  8. Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease.

    PubMed

    Wiersinga, Wilmar M

    2016-06-01

    Genetic factors contribute for about 70% to 80% and environmental factors for about 20% to 30% to the pathogenesis of autoimmune thyroid disease (AITD). Relatives of AITD patients carry a risk to contract AITD themselves. The 5-year risk can be quantified by the so-called Thyroid Events Amsterdam-score, based on serum thyroid-stimulating hormone, thyroid peroxidase (TPO)-antibodies and family history. Subjects at risk may ask what they can do to prevent development of AITD. This review summarizes what is known about modulation of exposure to environmental factors in terms of AITD prevention. To stop smoking decreases the risk on Graves disease but increases the risk on Hashimoto disease. Moderate alcohol intake provides some protection against both Graves and Hashimoto disease. Low selenium intake is associated with a higher prevalence of thyroid autoimmunity, but evidence that selenium supplementation may lower TPO antibodies and prevent subclinical hypothyroidism remains inconclusive. Low serum vitamin D levels are associated with a higher prevalence of TPO antibodies, but intervention studies with extra vitamin D have not been done yet. Stress may provoke Graves hyperthyroidism but not Hashimoto thyroiditis. Estrogen use have been linked to a lower prevalence of Graves disease. The postpartum period is associated with an increased risk of AITD. Taking together, preventive interventions to diminish the risk of AITD are few, not always feasible, and probably of limited efficacy. PMID:27184015

  9. Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease

    PubMed Central

    2016-01-01

    Genetic factors contribute for about 70% to 80% and environmental factors for about 20% to 30% to the pathogenesis of autoimmune thyroid disease (AITD). Relatives of AITD patients carry a risk to contract AITD themselves. The 5-year risk can be quantified by the so-called Thyroid Events Amsterdam-score, based on serum thyroid-stimulating hormone, thyroid peroxidase (TPO)-antibodies and family history. Subjects at risk may ask what they can do to prevent development of AITD. This review summarizes what is known about modulation of exposure to environmental factors in terms of AITD prevention. To stop smoking decreases the risk on Graves disease but increases the risk on Hashimoto disease. Moderate alcohol intake provides some protection against both Graves and Hashimoto disease. Low selenium intake is associated with a higher prevalence of thyroid autoimmunity, but evidence that selenium supplementation may lower TPO antibodies and prevent subclinical hypothyroidism remains inconclusive. Low serum vitamin D levels are associated with a higher prevalence of TPO antibodies, but intervention studies with extra vitamin D have not been done yet. Stress may provoke Graves hyperthyroidism but not Hashimoto thyroiditis. Estrogen use have been linked to a lower prevalence of Graves disease. The postpartum period is associated with an increased risk of AITD. Taking together, preventive interventions to diminish the risk of AITD are few, not always feasible, and probably of limited efficacy. PMID:27184015

  10. Using lidar data to analyse sinkhole characteristics relevant for understory vegetation under forest cover-case study of a high karst area in the dinaric mountains.

    PubMed

    Kobal, Milan; Bertoncelj, Irena; Pirotti, Francesco; Dakskobler, Igor; Kutnar, Lado

    2015-01-01

    In this article, we investigate the potential for detection and characterization of sinkholes under dense forest cover by using airborne laser scanning data. Laser pulse returns from the ground provide important data for the estimation of digital elevation model (DEM), which can be used for further processing. The main objectives of this study were to map and determine the geomorphometric characteristics of a large number of sinkholes and to investigate the correlations between geomorphology and vegetation in areas with such characteristics. The selected study area has very low anthropogenic influences and is particularly suitable for studying undisturbed karst sinkholes. The information extracted from this study regarding the shapes and depths of sinkholes show significant directionality for both orientation of sinkholes and their distribution over the area. Furthermore, significant differences in vegetation diversity and composition occur inside and outside the sinkholes, which indicates their presence has important ecological impacts. PMID:25793871

  11. An exploratory study of community factors relevant for participatory malaria control on Rusinga Island, western Kenya

    PubMed Central

    Opiyo, Pamela; Mukabana, W Richard; Kiche, Ibrahim; Mathenge, Evan; Killeen, Gerry F; Fillinger, Ulrike

    2007-01-01

    Background Capacity strengthening of rural communities, and the various actors that support them, is needed to enable them to lead their own malaria control programmes. Here the existing capacity of a rural community in western Kenya was evaluated in preparation for a larger intervention. Methods Focus group discussions and semi-structured individual interviews were carried out in 1,451 households to determine (1) demographics of respondent and household; (2) socio-economic status of the household; (3) knowledge and beliefs about malaria (symptoms, prevention methods, mosquito life cycle); (4) typical practices used for malaria prevention; (5) the treatment-seeking behaviour and household expenditure for malaria treatment; and (6) the willingness to prepare and implement community-based vector control. Results Malaria was considered a major threat to life but relevant knowledge was a chimera of scientific knowledge and traditional beliefs, which combined with socio-economic circumstances, leads to ineffective malaria prevention. The actual malaria prevention behaviour practiced by community members differed significantly from methods known to the respondents. Beside bednet use, the major interventions implemented were bush clearing and various hygienic measures, even though these are ineffective for malaria prevention. Encouragingly, most respondents believed malaria could be controlled and were willing to contribute to a community-based malaria control program but felt they needed outside assistance. Conclusion Culturally sensitive but evidence-based education interventions, utilizing participatory tools, are urgently required which consider traditional beliefs and enable understanding of causal connections between mosquito ecology, parasite transmission and the diagnosis, treatment and prevention of disease. Community-based organizations and schools need to be equipped with knowledge through partnerships with national and international research and tertiary

  12. Age-Related Changes in Immunological Factors and Their Relevance in Allergic Disease Development During Childhood

    PubMed Central

    Chang, Woo-Sung; Kim, Eun-Jin; Lim, Yeon-Mi; Yoon, Dankyu; Son, Jo-Young; Park, Jung-Won; Hong, Soo-Jong; Cho, Sang-Heon

    2016-01-01

    Purpose Allergic diseases are triggered by Th2-mediated immune reactions to allergens and orchestrated by various immunological factors, including immune cells and cytokines. Although many reports have suggested that childhood is the critical period in the onset of allergic diseases and aging leads to alter the susceptibility of an individual to allergic diseases, age-related changes in various immunological factors in healthy individuals as well as their difference between healthy and allergic children have not yet been established. Methods We investigated the ratio of Th1/Th2 cells and the levels of 22 allergy-related cytokines across all age groups in individuals who were classified as clinically non-atopic and healthy. We also examined their differences between healthy and allergic children to evaluate immunological changes induced by the development of allergic diseases during childhood. Results The Th1/Th2 ratio rose gradually during the growth period including childhood, reaching peak values in the twenties-thirties age group. Th1/Th2 ratios were significantly lower in allergic children than in healthy controls, whereas 14 of 22 cytokines were significantly higher in allergic children than in healthy controls. On the other hand, there were no differences in Th1/Th2 ratios and cytokines between healthy and allergic adolescents. Conclusions In this study, age-related changes in Th1/Th2 ratios were found in normal controls across all age groups, and decreases in Th1/Th2 ratio were observed with increasing of 14 cytokines in allergic children. The results of this study may be helpful as reference values for both monitoring immunological changes according to aging in healthy individuals and distinguishing between normal and allergic subjects in terms of immune cells and soluble factors. PMID:27126727

  13. ASD-relevant Animal Models of the Foxp Family of Transcription Factors

    PubMed Central

    Bowers, J. Michael; Konopka, Genevieve

    2013-01-01

    Autism is a neurodevelopmental disorder with a multifaceted association between genes and the environment. Currently, in the majority of patients, the etiology of autism is not known and coupled with increasing prevalence rates, along with the high degree of heritability of autism, the development of animal models is crucial for studying and developing therapies for autism. A key characteristic of autism is marked abnormalities in the acquisition and use of language. Thus, to understand and ultimately treat autism is an especially difficult task because no animal produces language, as it is defined in humans. In this review, we will discuss the FOXP family of genes, which are a group of transcription factors that have been linked to both autism, as well as language in humans. Due to the association of language/communication and the Foxp family of transcription factors, animal models with targeted disruptions of Foxp functioning are powerful tools for understanding the developmental signaling pathways that may be vulnerable in autism. PMID:24358452

  14. Soluble Epidermal Growth Factor Receptors (sEGFRs) in Cancer: Biological Aspects and Clinical Relevance.

    PubMed

    Maramotti, Sally; Paci, Massimiliano; Manzotti, Gloria; Rapicetta, Cristian; Gugnoni, Mila; Galeone, Carla; Cesario, Alfredo; Lococo, Filippo

    2016-01-01

    The identification of molecules that can reliably detect the presence of a tumor or predict its behavior is one of the biggest challenges of research in cancer biology. Biological fluids are intriguing mediums, containing many molecules that express the individual health status and, accordingly, may be useful in establishing the potential risk of cancer, defining differential diagnosis and prognosis, predicting the response to treatment, and monitoring the disease progression. The existence of circulating soluble growth factor receptors (sGFRs) deriving from their membrane counterparts has stimulated the interest of researchers to investigate the use of such molecules as potential cancer biomarkers. But what are the origins of circulating sGFRs? Are they naturally occurring molecules or tumor-derived products? Among these, the epidermal growth factor receptor (EGFR) is a cell-surface molecule significantly involved in cancer development and progression; it can be processed into biological active soluble isoforms (sEGFR). We have carried out an extensive review of the currently available literature on the sEGFRs and their mechanisms of regulation and biological function, with the intent to clarify the role of these molecules in cancer (and other pathological conditions) and, on the basis of the retrieved evidences, speculate about their potential use in the clinical setting. PMID:27104520

  15. Soluble Epidermal Growth Factor Receptors (sEGFRs) in Cancer: Biological Aspects and Clinical Relevance

    PubMed Central

    Maramotti, Sally; Paci, Massimiliano; Manzotti, Gloria; Rapicetta, Cristian; Gugnoni, Mila; Galeone, Carla; Cesario, Alfredo; Lococo, Filippo

    2016-01-01

    The identification of molecules that can reliably detect the presence of a tumor or predict its behavior is one of the biggest challenges of research in cancer biology. Biological fluids are intriguing mediums, containing many molecules that express the individual health status and, accordingly, may be useful in establishing the potential risk of cancer, defining differential diagnosis and prognosis, predicting the response to treatment, and monitoring the disease progression. The existence of circulating soluble growth factor receptors (sGFRs) deriving from their membrane counterparts has stimulated the interest of researchers to investigate the use of such molecules as potential cancer biomarkers. But what are the origins of circulating sGFRs? Are they naturally occurring molecules or tumor-derived products? Among these, the epidermal growth factor receptor (EGFR) is a cell-surface molecule significantly involved in cancer development and progression; it can be processed into biological active soluble isoforms (sEGFR). We have carried out an extensive review of the currently available literature on the sEGFRs and their mechanisms of regulation and biological function, with the intent to clarify the role of these molecules in cancer (and other pathological conditions) and, on the basis of the retrieved evidences, speculate about their potential use in the clinical setting. PMID:27104520

  16. Corticotropin-releasing factor peptide antagonists: design, characterization and potential clinical relevance

    PubMed Central

    Rivier, Jean E.; Rivier, Catherine L.

    2014-01-01

    Elusive for more than half a century, corticotropin-releasing factor (CRF) was finally isolated and characterized in 1981 from ovine hypothalami and shortly thereafter, from rat brain. Thirty years later, much has been learned about the function and localization of CRF and related family members (Urocortins 1, 2 and 3) and their 2 receptors, CRF receptor type 1 (CRFR1) and CRF receptor type 2 (CRFR2). Here, we report the stepwise development of peptide CRF agonists and antagonists, which led to the development of the CRFR1 agonist Stressin1; the long-acting antagonists Astressin2-B which is specific for CRFR2; and Astressin B, which binds to both CRFR1 and CRFR2. This analog has potential for the treatment of CRF-dependent diseases in the periphery, such as irritable bowel syndrome. PMID:24269930

  17. Psycho- and immunopharmacological factors relevant to selection of volunteers in clinical studies.

    PubMed

    Meyer, F P

    2001-07-01

    There are many well-known factors and variables which play a role in the evaluation of pharmacokinetic and pharmacodynamic results gained from healthy volunteers. The genetic constitution is influenced by age, sex, circadian and seasonal variations, dietary factors, immunological function, alcohol intake, smoking, etc. Vesell repeatedly pointed out these facts some time ago [Vesell 1982, Vesell and Passananti 1977]. Since Janke [1964], we have suspected that personality traits can also influence the drug response. The following overview is dedicated to this field designated as differential psychopharmacology which, from the point of view ofthe author, has been given too little attention by pharmacologists and clinical pharmacologists. It has been demonstrated that the effect of psychotropic drugs, including placebo, can be differentially influenced by personality traits, e.g. introversion/extroversion, high level neuroticism/low level neuroticism and success motivation/failure motivation. For example, relatively high doses of diazepam (0.3 mg/kg), when compared to placebo, only impaired the psychophysical performance of extroverted volunteers whereas introverted volunteers remained unaffected. Pharmacokinetic parameters, e.g. absorption, biotransformation, can also be affected by the level of neuroticism or by anxiety, as demonstrated for diazepam, caffeine, paracetamol and theophylline. The absorption kinetics of diazepam and caffeine clearly differ between volunteers with high neuroticism scores and those with low neuroticism scores. Emotionally unstable volunteers absorbed the substances more quickly and more completely than emotionally stable volunteers. There were surprising differences in various immunological indices between dominant and submissive subjects. In dominant volunteers the immune system was more activated than in submissive volunteers. In the future, it will become increasingly necessary to obtain results for such target groups and to avoid

  18. The global impact factors of net primary production in different land cover types from 2005 to 2011.

    PubMed

    Yu, Bo; Chen, Fang

    2016-01-01

    With the seriously polluted environment due to social development, the sustainability of net primary production (NPP), which is used to feed most lives on the earth, has become one of the biggest concerns that we have to consider for the sake of food shortage. There have been many researches analyzing one or two potential impact factors of NPP based on field observation data, which brings about many uncertainties for further calculation. Moreover, the frequently used process-based models heavily depend on the understandings of researchers about the NPP process. The premises of such models hinder the impact factor analysis from being objective and confident. To overcome such shortages, we collected 27 potential impact factors of global NPP in terms of eight land cover types. The feature variables include atmosphere, biosphere, anthroposphere and lithosphere parameters, which can be obtained from public available remote sensed products. The experiment shows that latitude, irradiance ultraviolet and normalized difference vegetation index are dominant factors impacting global NPP. Anthropogenic activities, precipitation and surface emissivity are influencing NPP calculation largely. However, some commonly used biosphere parameters in process-based models are actually not playing that important roles in NPP estimation. This work provides a new insight in analyzing NPP impact factors, being more objective and comprehensive compared with frequently used process-based models. PMID:27536518

  19. The Classical Assumption Test to Driving Factors of Land Cover Change in the Development Region of Northern Part of West Java

    NASA Astrophysics Data System (ADS)

    Ainiyah, Nur; Deliar, Albertus; Virtriana, Riantini

    2016-06-01

    Land cover changes continuously change by the time. Many kind of phenomena is a simple of important factors that affect the environment change, both locally and also globally. To determine the existence of the phenomenon of land cover change in a region, it is necessary to identify the driving factors that can cause land cover change. The relation between driving factors and response variables can be evaluated by using regression analysis techniques. In this case, land cover change is a dichotomous phenomenon (binary). The BLR's model (Binary Logistic Regression) is the one of kind regression analysis which can be used to describe the nature of dichotomy. Before performing regression analysis, correlation analysis is carried it the first. Both correlation test and regression tests are part of a statistical test or known classical assumption test. From result of classical assumption test, then can be seen that the data used to perform analysis from driving factors of the land cover changes is proper with used by BLR's method. Therefore, the objective of this research is to evaluate the effectiveness of methods in assessing the relation between driving factors of land cover change that assumed can affect to land cover change phenomena. This research will use the classical assumed test of multiple regression linear analysis, showing that BLR method is efficiency and effectiveness solution for researching or studying in phenomenon of land cover changes. So it will to provide certainty that the regression equation obtained has accuracy in estimation, unbiased and consistent.

  20. Clinical relevance of the biochemical, metabolic, and genetic factors that influence low-density lipoprotein heterogeneity.

    PubMed

    Kwiterovich, Peter O

    2002-10-17

    Traditional risk factors for coronary artery disease (CAD) predict about 50% of the risk of developing CAD. The Adult Treatment Panel (ATP) III has defined emerging risk factors for CAD, including small, dense low-density lipoprotein (LDL). Small, dense LDL is often accompanied by increased triglycerides (TGs) and low high-density lipoprotein (HDL). An increased number of small, dense LDL particles is often missed when the LDL cholesterol level is normal or borderline elevated. Small, dense LDL particles are present in families with premature CAD and hyperapobetalipoproteinemia, familial combined hyperlipidemia, LDL subclass pattern B, familial dyslipidemic hypertension, and syndrome X. The metabolic syndrome, as defined by ATP III, incorporates a number of the components of these syndromes, including insulin resistance and intra-abdominal fat. Subclinical inflammation and elevated procoagulants also appear to be part of this atherogenic syndrome. Overproduction of very low-density lipoproteins (VLDLs) by the liver and increased secretion of large, apolipoprotein (apo) B-100-containing VLDL is the primary metabolic characteristic of most of these patients. The TG in VLDL is hydrolyzed by lipoprotein lipase (LPL) which produces intermediate-density lipoprotein. The TG in intermediate-density lipoprotein is hydrolyzed further, resulting in the generation of LDL. The cholesterol esters in LDL are exchanged for TG in VLDL by the cholesterol ester tranfer proteins, followed by hydrolysis of TG in LDL by hepatic lipase which produces small, dense LDL. Cholesterol ester transfer protein mediates a similar lipid exchange between VLDL and HDL, producing a cholesterol ester-poor HDL. In adipocytes, reduced fatty acid trapping and retention by adipose tissue may result from a primary defect in the incorporation of free fatty acids into TGs. Alternatively, insulin resistance may promote reduced retention of free fatty acids by adipocytes. Both these abnormalities lead to

  1. The Potential Risk Factors Relevant to Lateral Epicondylitis by Wrist Coupling Posture

    PubMed Central

    Lee, Su-Ya; Chieh, Hsiao-Feng; Lin, Chien-Ju; Jou, I-Ming; Kuo, Li-Chieh; Su, Fong-Chin

    2016-01-01

    The use of awkward wrist postures and unskilled techniques might induce lateral epicondylitis. This study thus investigated the effects of wrist deviation combined with extension and movement velocity on the dynamic performances of the wrist muscles during the coupling posture via a custom-made bi-planar isokinetic dynamometer. Thirty subjects were recruited to perform the isokinetic testing. We measured the muscle strengths and activities for the wrist extensors and flexors during concentric and eccentric contractions at three movement velocities, 30°s-1, 90°s-1, and 180°s-1, combined with three wrist postures, neutral position (NP), radial deviation (RD), and ulnar deviation (UD). The root mean square (RMS) of the electromyographic signal in the extensor digitorum communis (EDC), normalized peak torque of extensors, and ratio of normalized peak torque between wrist extensors and flexors, were all greater in the NP than RD and UD in both contractions. The ratio of RMS between EDC and flexor digitorum superficialis (FDS) had a significantly greater value in RD than UD during the concentric contraction. The EDC showed significantly higher activity at the fast velocity in both contractions. Nevertheless, a significantly higher RMS of the electromyographic signal between EDC and FDS and the ratio of strength between wrist extensors and flexors were found at slow velocity in both contractions. The wrist deviation combined with extension and movement velocity of the wrist joint should thus be considered as influential factors which might alter the dynamic performances, and may result in further injury of the elbow joint. PMID:27171198

  2. Students’ Aggression and Its Relevance to Personal, Family, and Social Factors

    PubMed Central

    Alami, Ali; Shahghasemi, Zohreh; Davarinia Motlagh Ghochan, Arezoo; Baratpour, Fateme

    2015-01-01

    Background: Aggression is defined as behaviors intended to hurt, harm, or injure another person. Aggression is by no means a new concern in human society, especially in youth. Universities are among the institutions in which most of the members are young people and because of facing with various personal and social stressors, the students usually experience high level of stress. Objectives: This study aimed to determine aggression among university students and its association with their personal, family, and social characteristics. Materials and Methods: This cross-sectional, analytic study was conducted on a representative sample (n = 809) of university students (1 state university and 2 private universities) locating in Gonabad, Iran in 2012. Using proportional to size stratified sampling, we selected the respondents and gathered the required data using a valid and reliable questionnaire. The data were entered into SPSS (version 20) and analyzed through t test, ANOVA, and regression model. Results: A total of 381 (47.2%) male and 428 (52.8%) female students participated in the study. Mean (SD) age of the respondents was 21.79 (2.86) years. Overall mean aggression score (SD) in the students was 72.45 (15.49) and this score for in dorm and out of dorm students was 74.31 (15.59) and 70.93 (15.23), respectively. There were significant associations between the mean aggression score of dormitory students and sex (P = 0.004), age (P = 0.044), and type of the university (P = 0.039). On the other hand, there was no significant association between all independent factors and mean aggression score of students living out of dorm. Conclusions: Regarding the control of aggressive behaviors, paying attention to male, young students living in dormitory, especially in non-governmental universities has the highest priority. PMID:26756005

  3. Modelling of INTER-Linkages Between LAND Cover Pattern and Socio-Economic Factors in the Idemili River Basin of South Eastern Nigeria

    NASA Astrophysics Data System (ADS)

    Maduekwe, N. I.; Adesina, F. A.

    2014-12-01

    This study explores the inter-relationships between socio-economic factors and land cover pattern in the Idemili River Basin of South Eastern Nigeria. It is based on the concept of coupled human environment systems and focuses on the modelling of community scale relationships between critical land cover parameter and socio-demographic, economic and cultural factors in the basin. The modelling was implemented with pixel level NDVI indicators of vegetation cover density developed from NigeriaSat image with 32m resolution linked to eight indicators of socio-economic factors developed from a household survey of the basin. NDVI and socio-economic data were matched for 25 sampled localities in the basin and their relationships modelled with correlation, regression and Principal Component Analysis statistics. NDVI based image analysis showed a high level of human impact on vegetation. The Model output shows that bivariate relationships between vegetation cover dynamics and socio-demographic variables were the most significant, with R Square values > 0.60 for linear and non linear models. Vegetation cover density has high inverse correlations with population, urbanization levels and number of households in localities. Population/urbanization status of localities was also the most significant Principal Component or underlying dimension linked to spatial dynamics of vegetation cover in the basin accounting for 50% of factor variations. Relationships between vegetation cover densities and economic factors (occupational and household energy patterns) and socio-cultural factors (environmental knowledge, values and governance) were weaker and less significant. The study captured the linkages between landcover- represented by vegetation cover- and socio-economic parameters. It demonstrates that socio-economic factors are major drivers of change in the basin. Key Words: Socio-economic factors, Vegetation Cover, NDVI, Socio-ecological Systems, State Variables, South Eastern Nigeria

  4. Normal people in clinical practice: a general factor of personality in biproportional scaling and its practical relevance.

    PubMed

    Mosterman, Regina M

    2013-01-01

    To investigate the clinical relevance of absolute scaling in personality assessment, Hofstee and Ten Berge's (2004) biproportional scaling method was applied to 3 clinical samples and compared with relative scaling in traditional analyses. In the first sample, 80 psychotherapy clients provided self-reports as well as reports by 3 informants, resulting in 320 ratings of the Dutch short form of the MMPI (NVM). In the second sample, 96 psychotherapy clients provided self-reports and informant reports, resulting in 384 Five-Factor Personality Inventory (FFPI) ratings. In the third sample, 95 clients provided self-reports and informant reports, resulting in 380 ratings of the NEO Five-Factor Inventory (NEO-FFI). In Part I of the study, the personality structure based on biproportional scaling was examined by replicating Hofstee, Barelds, and Ten Berge (2006). In Part II, this personality structure as well as self-informant distances and self-informant likenesses were related to symptoms, personality pathology, and level of functioning. The results confirmed the presence of a general factor of personality in absolute scaling, which appears to reflect social fitness and the absence of severe psychopathology. This factor was significantly associated with fewer symptoms and better functioning in all 3 samples. The personality pathology results were only significant in the FFPI sample. Self-informant distance and self-informant likeness were primarily associated with symptoms. A relationship between poor social fitness and insecure early attachment was suggested in 3 case studies. PMID:22809082

  5. Interrelation among climate factors, snow cover, grassland vegetation, and lake in the Nam Co basin of the Tibetan Plateau

    NASA Astrophysics Data System (ADS)

    Chen, Siyu; Liang, Tiangang; Xie, Hongjie; Feng, Qisheng; Huang, Xiaodong; Yu, Hui

    2014-01-01

    Taking Nam Co basin as an example, we examine the interrelationship among vegetation growth, lake expansion, snow cover, and climate change, based on meteorological data and multisource remote sensing datasets. Results show that the climate has become warmer and wetter during the period of time from 1961 to 2010, with rates of +0.04°C/year (P<0.001) for annual mean temperature and +1.66 mm/year (P=0.007) for annual precipitation, while the snow-covered index experienced a decreasing trend (-31.94 km2.day/year, P=0.129) from 2003 to 2010. In response, the vegetation growth was deteriorative in most parts of the basin. Conversely, both the lake's area and water level increased (+2.15 km2/year and +0.12 m/year, respectively). Although the enhanced vegetation index in the basin negatively correlates well with the lake's area (R2=0.75, P=0.001), the correlation shows gradual decrease as distance away from the lake's shoreline, from 25 km (zone A), to 25-50 km (zone B), and to 50-95 km (zone C). Two main factors might have contributed to this: (1) lake expansion buried grassland vegetation in zone A and (2) more gravel buildup and soil erosion due to runoff from snow melted water in zone A than in zones B and C. This study provides a scientific basis for the evaluation of changes in alpine grassland, lake, snow cover, and their responses to climate change.

  6. [Responses of net soil nitrogen mineralization rate in moss-covered soil to hydrothermic factors in Shapotou regions, northern China].

    PubMed

    Hu, Rui; Wang, Xin-Ping; Pan, Yan-Xia; Zhang, Ya-Feng; Zhang, Ke; Zhang, Hao

    2014-02-01

    Undisturbed soil cores were incubated in laboratory at different temperatures (-10, 5, 15, 25, 35 and 40 degrees C) and moistures (29%, 58%, 85% and 170% of field water content, FWC) to analyze the effect of moss crusts, which were sampled from the natural vegetation area of Shapotou, on soil nitrogen transformation and their responses to hydrothermic factors. Results showed that immobilization was the dominant form of nitrogen transformation at the lower temperatures (<15 degrees C), and when the temperature surpassed 25 degrees C, the nitrogen transformation rate significantly increased. The nitrogen transformation rate in the moss-covered soil was more sensitive to temperature variation than in the bare soil, and the highest temperature sensitivity was at 85% FWC. It indicated that the existence and succession of moss crusts facilitated nitrogen transformation. In addition, the nitrogen transformation rates of two microhabitats increased initially and then declined with the increasing moisture, and the maximum nitrogen transformation rate was observed at 85% FWC. Significant interactive effects were found between temperature and moisture in the moss-covered soil. While, the greater enhancement in nitrogen transformation rate appeared at higher temperatures (25-40 degrees C ) and moderate moisture levels (58% FWC and 85% FWC). It was concluded that the existence and succession of moss crusts would increase the ability of soil nitrogen supply, promote nitrogen cycling and even contribute to the restoration of soil ecosystem. PMID:24830238

  7. The characteristics and relevant factors of Pap smear test use for women with intellectual disabilities in Taiwan

    PubMed Central

    2014-01-01

    Background This study examines the Pap smear usage conditions and relevant influential factors for 18,204 women aged 30 years and above with intellectual disabilities, using nationwide data from 2008. Methods The research method of this study is secondary data analysis. The data was obtained from three nationwide databases from 2006 to 2008. This study employed descriptive statistics to analyze the use and rate of Pap smear testing by women with intellectual disabilities. Chi-square test was used to assess the correlation between Pap smear test usage and several variables. Logistic regression analysis was employed to explore the factors that influence Pap smear test usage. Results The results show that 4.83% (n =880) of women with intellectual disabilities underwent Pap smear tests. Pap smear test usage rates exhibit a declining trend with increases in age. Factors that significantly influence Pap smear test use include age, urbanization level of resident area, monthly salary, aboriginal status, marital status, existence of DM, severity of disability. Conclusions The women with intellectual disabilities had a low use rate of Pap smear test, which is significantly less than the 28.8% usage rate for the general population of women aged 30 years and above. PMID:24890828

  8. Relevance of the transcription factor PdSte12 in Penicillium digitatum conidiation and virulence during citrus fruit infection.

    PubMed

    Vilanova, Laura; Teixidó, Neus; Torres, Rosario; Usall, Josep; Viñas, Inmaculada; Sánchez-Torres, Paloma

    2016-10-17

    Green mould, resulting from Penicillium digitatum, is the most important postharvest disease of citrus. In a previous study, the PdSte12 transcription factor gene was identified, and disruption mutants were obtained. In the present study, the ΔPdSte12 mutants generated through gene replacement showed significantly reduced virulence during citrus fruit infection. Virulence was affected not only in mature fruit but also in immature fruit, and disease severity was markedly reduced when the oranges were stored at 20 or 4°C. In addition, the ΔPdSte12 mutants were defective in asexual reproduction, producing few conidia. The conidiophores of these mutants had longer metulae with fewer branches at the tip of the hyphae. Gene expression analysis revealed that PdSte12 might act as a negative regulator of several transporter-encoding genes and a positive regulator of two sterol demethylases, all of which are involved in fungicide resistance and fungal virulence. Moreover, PdSte12 exhibited the negative regulation of another transcription factor PdMut3, putatively involved in fungal pathogenesis but with no effect on the MAPK SLT2 P. digitatum orthologue belonging to different transcription pathways relevant to cell integrity. These results indicate the PdSte12 transcription factor is functionally conserved in P. digitatum for infection and asexual reproduction, similar to other Ste12 fungal plant pathogens. PMID:27479695

  9. Cell Injury-Induced Release of Fibroblast Growth Factor 2: Relevance to Intracerebral Mesenchymal Stromal Cell Transplantations.

    PubMed

    Aizman, Irina; Vinodkumar, Deepti; McGrogan, Michael; Bates, Damien

    2015-07-15

    Beneficial effects of intracerebral transplantation of mesenchymal stromal cells (MSC) and their derivatives are believed to be mediated mostly by factors produced by engrafted cells. However, the mesenchymal cell engraftment rate is low, and the majority of grafted cells disappear within a short post-transplantation period. Here, we hypothesize that dying transplanted cells can affect surrounding tissues by releasing their active intracellular components. To elucidate the type, amounts, and potency of these putative intracellular factors, freeze/thaw extracts of MSC or their derivatives were tested in enzyme-linked immunosorbent assays and bioassays. We found that fibroblast growth factor (FGF)2 and FGF1, but not vascular endothelial growth factor and monocyte chemoattractant protein 1 levels were high in extracts despite being low in conditioned media. Extracts induced concentration-dependent proliferation of rat cortical neural progenitor cells and human umbilical vein endothelial cells; these proliferative responses were specifically blocked by FGF2-neutralizing antibody. In the neuropoiesis assay with rat cortical cells, both MSC extracts and killed cells induced expression of nestin, but not astrocyte differentiation. However, suspensions of killed cells strongly potentiated the astrogenic effects of live MSC. In transplantation-relevant MSC injury models (peripheral blood cell-mediated cytotoxicity and high cell density plating), MSC death coincided with the release of intracellular FGF2. The data showed that MSC contain a major depot of active FGF2 that is released upon cell injury and is capable of acutely stimulating neuropoiesis and angiogenesis. We therefore propose that both dying and surviving grafted MSC contribute to tissue regeneration. PMID:25873141

  10. Luminosity and redshift dependence of the covering factor of active galactic nuclei viewed with WISE and Sloan digital sky survey

    SciTech Connect

    Toba, Y.; Matsuhara, H.; Oyabu, S.; Malkan, M. A.; Gandhi, P.; Nakagawa, T.; Isobe, N.; Shirahata, M.; Oi, N.; Takita, S.; Yano, K.; Ohyama, Y.; Yamauchi, C.

    2014-06-10

    In this work, we investigate the dependence of the covering factor (CF) of active galactic nuclei (AGNs) on the mid-infrared (MIR) luminosity and the redshift. We constructed 12 and 22 μm luminosity functions (LFs) at 0.006 ≤z ≤ 0.3 using Wide-field Infrared Survey Explorer (WISE) data. Combining the WISE catalog with Sloan Digital Sky Survey (SDSS) spectroscopic data, we selected 223,982 galaxies at 12 μm and 25,721 galaxies at 22 μm for spectroscopic classification. We then identified 16,355 AGNs at 12 μm and 4683 AGNs at 22 μm by their optical emission lines and cataloged classifications in the SDSS. Following that, we estimated the CF as the fraction of Type 2 AGN in all AGNs whose MIR emissions are dominated by the active nucleus (not their host galaxies) based on their MIR colors. We found that the CF decreased with increasing MIR luminosity, regardless of the choice of Type 2 AGN classification criteria, and the CF did not change significantly with redshift for z ≤ 0.2. Furthermore, we carried out various tests to determine the influence of selection bias and confirmed that similar dependences exist, even when taking these uncertainties into account. The luminosity dependence of the CF can be explained by the receding torus model, but the 'modified' receding torus model gives a slightly better fit, as suggested by Simpson.

  11. The level of knowledge and awareness about prostate cancer in the Turkish male and the relevant effective factors

    PubMed Central

    Turkan, Sadi; Doğan, Faruk; Ekmekçioğlu, Ozan; Çolak, Aslıhan; Kalkan, Mehmet; Şahin, Çoşkun

    2016-01-01

    Objective Our aim was to determine the general knowledge and awareness levels, information sources, and the state of medical check-up for prostate cancer (PCa) and relevant effective factors. Material and methods The participants were asked to answer to 14 questions of a questionnaire about age, education, economic and social condition, knowledge about PCa, state of being examined and their related factors. According to demographic characteristics of the participants, levels of awareness about PCa, sources of information, affecting factors and their interrelationships were examined. Two groups were formed according to age (<60 years, >60 years) and variations according to ages were investigated. Results Two hundred and ninety-three men with an average age of 57 years (range 40–85) were included in the study. Our findings showed that 68.3% of the participants were thinking that PCa is a frequently seen disease, 88.4% were thinking that it can be treated and 62.8% of men specified that their information sources are doctors. We also found that 60.8% of the participants had not undergone prostate examination and prostate specific antigen (PSA) control. The most reason for not having annual examinations was (44.4%) “negligence”. Significantly greater number of men with higher education (high school/university) were highly informed about PCa (p=0.037). Check-up rates were statistically significantly higher among men with intermediate income (p=0.041). Curability of PCa diagnosed at an early stage was acknowledged by statistically higher number of individuals under the age 60 (p<0.05). Health control, prostate examination and/or PSA control rates were higher in men with a family history of PCa and in the group of >60 years. Conclusion Although PCa has a high prevalence and mortality rates, personal and social information and sensitivity levels must be increased as it can be treated if diagnosed at an early stage. We think that social and medical impact of the

  12. Land cover or climate? In search of dominant factors inducing groundwater recharge and fen hydrology in European scale

    NASA Astrophysics Data System (ADS)

    Grygoruk, Mateusz; Kotowski, Wiktor

    2016-04-01

    Groundwater recharge plays the crucial role in development and stability of fens. It was hypothesized that the mid- and late-Holocene acceleration of fens' development in Europe could have been induced by changes in land cover: decreasing areas of forests resulting from the expanding agriculture have enhanced groundwater recharge by decreasing evapotranspiration and interception and promoting infiltration. However, regardless human-related changes of the landscape, recorded climatic fluctuations could also be considered as drivers of changing groundwater recharge that affects fen stability and development. Nowadays, when up to 90% of European wetlands is considered degraded, assessing vulnerability of groundwater recharge to changing landscape and climate is of the crucial importance for setting fen restoration and management strategies. Main goal of our study was to assess the magnitude of changes in groundwater recharge estimation resulting from modelled changes of the landscape and climatic features in >300 fens located in Poland, Germany, The Netherlands, Sweden, UK and Norway. In our approach we (1) delineated the most probable extents of catchments of particular fens analysed, (2) assumed hypothetical and the most probable changes of land cover within these catchments, (3) assumed the most probable ranges of climatic changes in each of the catchments including historical reconstructions (Holocene) and future projections (A1B scenario, CSIRO:MK3 and UKMO:HADCM3 GCM-RCM ensembles), (4) developed, tested and calibrated automatic, GIS-based groundwater recharge calculation algorithm to be applied in the study, (5) calculated groundwater recharge in multiple probable combinations of landscape and climatic conditions and (6) performed statistical analysis in order to reveal whether the climate or landscape changes were the dominant factors that could have probably influenced groundwater recharge in catchments of fens analysed. We revealed that in the case of 80% of

  13. Gas-phase organics in environmental tobacco smoke: 2. Exposure-relevant emission factors and indirect exposures from habitual smoking

    NASA Astrophysics Data System (ADS)

    Singer, Brett C.; Hodgson, Alfred T.; Nazaroff, William W.

    Sorption of emitted gas-phase organic compounds onto material surfaces affects environmental tobacco smoke (ETS) composition and exposures indoors. We have introduced a new metric, the exposure relevant emission factor (EREF) that accounts for sorptive uptake and reemission to give the mass of individual ETS constituents available for exposure over a day in which smoking occurs. This paper describes month-long experiments to investigate sorption effects on EREFs and potential ETS exposures under habitual smoking conditions. Cigarettes were smoked in a 50-m 3 furnished room over a 3-h period 6-7 days per week, with continuous ventilation at 0.3, 0.6, or 2.1 h -1. Organic gas concentrations were measured every few days over 4-h "smoking", 10-h "post-smoking" and 10-h "background" periods. Concentration patterns of volatile ETS components including 1,3-butadiene, benzene and acrolein were similar to those calculated for a theoretical non-sorbing tracer, indicating limited sorption. Concentrations of ETS tracers, e.g. 3-ethenylpyridine (3-EP) and nicotine, and lower volatility toxic air contaminants including phenol, cresols, and naphthalene increased as experiments progressed, indicating mass accumulation on surfaces and higher desorption rates. Daily patterns stabilized after week 2, yielding a steady daily cycle of ETS concentrations associated with habitual smoking. EREFs for sorbing compounds were higher under steady cycle versus single-day smoking conditions by ˜50% for 3-EP, and by 2-3 times for nicotine, phenol, cresols, naphthalene, and methylnaphthalenes. Our results provide relevant information about potential indirect exposures from residual ETS (non-smoker enters room shortly after smoker finishes) and from reemission, and their importance relative to direct exposures (non-smoker present during smoking). Under the conditions examined, indirect exposures accounted for a larger fraction of total potential exposures for sorbing versus non-sorbing compounds

  14. Plant available silicon in South-east Asian rice paddy soils - relevance of agricultural practice and of abiotic factors

    NASA Astrophysics Data System (ADS)

    Marxen, A.; Klotzbücher, T.; Vetterlein, D.; Jahn, R.

    2012-12-01

    Background Silicon (Si) plays a crucial role in rice production. Si content of rice plants exceeds the content of other major nutrients such as nitrogen, phosphorous or potassium. Recent studies showed that in some environments external supply of Si can enhance the growth of rice plants. Rice plants express specific Si transporters to absorb Si from soil solutions in form of silicic acid, which precipitates in tissue cells forming amorphous silica bodies, called phytoliths. The phytoliths are returned to soils with plant residues. They might be a main source of plant available silicic acid in soils. Aims In this study we assess the effects of rice paddy cultivation on the stocks of `reactive` Si fractions in mineral topsoils of rice paddy fields in contrasting landscapes. The `reactive` Si fractions are presumed to determine the release of plant-available silicic acid in soils. We consider the relevance of abiotic factors (mineral assemblage; soil weathering status) and agricultural practice for these fractions. Agricultural practices, which were assumed to affect the stocks of `reactive` Si were (i) the usage of different rice varieties (which might differ in Si demand), (ii) straw residue management (i.e., whether straw residues are returned to the fields or removed and used e.g. as fodder), and (iii) yield level and number of crops per year. Material and methods Soils (top horizon of about 0-20 cm depth) were sampled from rice paddy fields in 2 mountainous and 5 lowland landscapes of contrasting geologic conditions in Vietnam and the Philippines. Ten paddy fields were sampled per landscape. The rice paddy management within landscapes differed when different farmers and/or communities managed the fields. We analysed the following fractions of `reactive` Si in the soils: acetate-extractable Si (dissolved and easily exchangeable Si), phosphate-extractable Si (adsorbed Si), oxalate extractable Si (Si associated with poorly-ordered sesquioxides), NaOH extractable Si

  15. [Monitoring of seasonal variation of vegetation cover and evaluation of biological-control factor in orchards of China].

    PubMed

    Yu, Yue; Zhang, Wen-bo; Wang, Guo-yan

    2015-03-01

    Biological-control factor (B) can quantitatively reflect the effect of vegetation on soil erosion. Vertical photography method was used to monitor the seasonal changes of orchard coverage in 18 small watersheds, covering all five water erosion zones in China. The canopy coverage and ground green coverage were then calculated, and the B values were estimated. The result indicated that the orchard canopy coverage varied with season and distributed with a bell shape. The trend of ground green coverage and total coverage changed with season and was affected by the land management. For the orchard where the land surface was not treated and the weeds could grow freely, the distribution of the green coverage season change for all five soil erosion zones had a bell shape. The total coverage in the Northwest Loess Plateau area changed with season with a bell shape as well. The total coverage in the other four areas did not vary with the season and almost kept constant. For the orchard where land surface was cleaned up from time to time, the green coverage and total coverage in all five water erosion areas irregularly varied with season. The average B value of orchards in Northeast black soil area was the minimum with a value of 0.0006, while that in the Northwest Loess Plateau area was the maximum (0.1212). The average orchard B values in the Northern rocky earthy area, the Southern red soil area and the Southwest rocky earthy area were not significantly different and were 0.0548, 0.0627 and 0.0639, respectively. PMID:26211057

  16. The associated factors to endometrial cavity fluid and the relevant impact on the IVF-ET outcome

    PubMed Central

    2010-01-01

    Background Endometrial cavity fluid (ECF) is a fluid accumulation within the endometrial cavity. The significance of ECF remains unclear during the program of in vitro fertilization-embryo transfer (IVF-ET). The aim of the present study was to investigate the associated factors to ECF, visualized through ultrasound at the day of oocyte retrieval, and the relevant impact on the outcome of IVF-ET. Methods From the clinical data of 1557 infertility patients for IVF-ET program, 46 ECF patients were retrospectively selected as the ECF group; and another 134 patients with a bilateral salpingectomy and without ECF, selected as the control group. The demographics and the outcome of IVF-ET were compared between the two groups. Results The incidence of ECF was 2.95% (46/1557). Over half (28/46, 60.87%) of ECF patients had tubal infertility. Only 12 Of 46 ECF patients (26.09%) had visible hydrosalpinx on ultrasonography before ovarian stimulation. The cycle cancellation rate (4/46, 8.69%) of ECF group was not significantly higher than that of the control group (6/134, 4.48%; P > 0.05). Reasons for cycle cancellation in both groups were all the high risk of ovarian hyperstimulation syndrome (OHSS). No significant difference was found in clinical pregnancy rate between the patients with their ECF <3.5 mm in the anterior-posterior diameter (APD) and the control group (35.48% versus 30.47%; P > 0.05). No clinical pregnancy was found among those patients with their ECF equal or higher 3.5 mm in APD. Conclusions It was tubal infertility, not hydrosalpinx, which was related to the development of ECF. Excessive ECF (equal or higher 3.5 mm in APD) at the day of oocyte retrieval would have a negative impact on the outcome of IVF-ET. PMID:20465847

  17. Biotic and abiotic factors influencing the long-term stability of covers on waste rock piles in the uranium mining district of Saxony and Thuringia (Germany)

    SciTech Connect

    Heinze, M.; Koehler, M.; Saenger, H.

    1999-07-01

    This report presents the results of basic investigations of root penetration on various partially covered excavation discard material mounds of the Saxonian-Thuringian uranium mining region (Germany) in comparison to root penetration in autochthonous (native) soils. Bioturbation is an essential, unavoidable impact to consider in addition to root penetration. With increasing age, the functionality of each layer of a cover system becomes diminished through the workings of the local flora and fauna. Pedological cover layers can only temporarily maintain their initial positions and technical functionality. Considering actual prevailing biotic and abiotic influences (e.g., site-specific transpiration rates), the planning and installation of cover systems should take into account (within acceptable balances) factors which are able to at least partially compensate for eventual diminishing of technical functionality.

  18. Fine scale spatial urban land cover factors associated with adult mosquito abundance and risk in Tucson, Arizona.

    PubMed

    Landau, Katheryn I; van Leeuwen, Willem J D

    2012-12-01

    It is currently unclear what role microhabitat land cover plays in determining the seasonal spatial distribution of Aedes aegypti and Culex quinquefasciatus, disease vectors of dengue and West Nile Virus, respectively, in Tucson, AZ. We compared mosquito abundance to sixteen land cover variables derived from 2010 NAIP multispectral data and 2008 LiDAR height data. Mosquitoes were trapped with 30-9 traps from May to October of 2010 and 2011. Variables were extracted for five buffer zones (10-50 m radii at 10 m intervals) around trapping sites. Stepwise regression was performed to determine the best scale for observation and the influential land cover variables. The 30 m radius buffer was determined to be the best for observing the land cover-mosquito abundance relationship. Ae. aegypti presence was positively associated with structure and medium height trees and negatively associated with bare earth; Cx. quinquefasciatus presence was positively associated with pavement and medium height trees and negatively associated with shrubs. These findings emphasize vegetation, impervious surfaces, and soil influences on mosquito presence in an urban setting. Lastly, the land cover-mosquito abundance relationships were used to produce risk maps of seasonal presence that highlight high risk areas in Tucson, which may be useful for focusing mosquito control program actions. PMID:23181866

  19. Evaluation and comparison of benchmark QSAR models to predict a relevant REACH endpoint: The bioconcentration factor (BCF)

    SciTech Connect

    Gissi, Andrea; Lombardo, Anna; Roncaglioni, Alessandra; Gadaleta, Domenico; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio; Benfenati, Emilio

    2015-02-15

    The bioconcentration factor (BCF) is an important bioaccumulation hazard assessment metric in many regulatory contexts. Its assessment is required by the REACH regulation (Registration, Evaluation, Authorization and Restriction of Chemicals) and by CLP (Classification, Labeling and Packaging). We challenged nine well-known and widely used BCF QSAR models against 851 compounds stored in an ad-hoc created database. The goodness of the regression analysis was assessed by considering the determination coefficient (R{sup 2}) and the Root Mean Square Error (RMSE); Cooper's statistics and Matthew's Correlation Coefficient (MCC) were calculated for all the thresholds relevant for regulatory purposes (i.e. 100 L/kg for Chemical Safety Assessment; 500 L/kg for Classification and Labeling; 2000 and 5000 L/kg for Persistent, Bioaccumulative and Toxic (PBT) and very Persistent, very Bioaccumulative (vPvB) assessment) to assess the classification, with particular attention to the models' ability to control the occurrence of false negatives. As a first step, statistical analysis was performed for the predictions of the entire dataset; R{sup 2}>0.70 was obtained using CORAL, T.E.S.T. and EPISuite Arnot–Gobas models. As classifiers, ACD and log P-based equations were the best in terms of sensitivity, ranging from 0.75 to 0.94. External compound predictions were carried out for the models that had their own training sets. CORAL model returned the best performance (R{sup 2}{sub ext}=0.59), followed by the EPISuite Meylan model (R{sup 2}{sub ext}=0.58). The latter gave also the highest sensitivity on external compounds with values from 0.55 to 0.85, depending on the thresholds. Statistics were also compiled for compounds falling into the models Applicability Domain (AD), giving better performances. In this respect, VEGA CAESAR was the best model in terms of regression (R{sup 2}=0.94) and classification (average sensitivity>0.80). This model also showed the best regression (R{sup 2

  20. Variation of crack intensity factor in three compacted clay liners exposed to annual cycle of atmospheric conditions with and without geotextile cover.

    PubMed

    Safari, E; Jalili Ghazizade, M; Abduli, M A; Gatmiri, B

    2014-08-01

    Performance of compacted clay liners commonly used as landfill barrier systems can be subject to decline in terms of hydraulic conductivity if left exposed to atmospheric conditions for an extended period of time prior to placement of overlaying layers. The resulting desiccation cracking can lead to increased hydraulic conductivity. Desiccation crack intensity was studied for three clayey soils commonly used for construction of landfill barrier system in a relatively large scale test setup exposed to real time atmospheric conditions over a complete annual cycle. A white separator geotextile cover was presumed to be capable of reducing the intensity of desiccation cracking through absorbing and maintaining higher amounts of moisture and reducing the temperature of the soil surface in comparison to a directly exposed soil surface. Desiccation cracking was monitored using a digital imaging technique for three compacted clay liners in two sets, one open to air and the second covered with the white geotextile. Crack intensity factor approached a relatively stable phase after certain cycles corresponding to atmospheric dry wet cycles. The results indicated that the white separator geotextile was capable of reducing the crack intensity factor by 37.4-45.9% throughout the experiment including the cyclic phase of desiccation cracking. During the stable phase, the maximum reduction in crack intensity factor of 90.4% as a result of applying geotextile cover was observed for the soil with the lowest plastic index and clay content and therefore the lowest magnitude of crack intensity factor. The other two soils with similar clay content but different plastic index showed 23.6% and 52.2% reductions in crack intensity factor after cyclic phase when covered with geotextile. PMID:24820661

  1. Evaluating emotional sensitivity and tolerance factors in the prediction of panic-relevant responding to a biological challenge.

    PubMed

    Kutz, Amanda; Marshall, Erin; Bernstein, Amit; Zvolensky, Michael J

    2010-01-01

    The current study investigated anxiety sensitivity, distress tolerance (Simons & Gaher, 2005), and discomfort intolerance (Schmidt, Richey, Cromer, & Buckner, 2007) in relation to panic-relevant responding (i.e., panic attack symptoms and panic-relevant cognitions) to a 10% carbon dioxide enriched air challenge. Participants were 216 adults (52.6% female; M(age)=22.4, SD=9.0). A series of hierarchical multiple regressions was conducted with covariates of negative affectivity and past year panic attack history in step one of the model, and anxiety sensitivity, discomfort intolerance, and distress tolerance entered simultaneously into step two. Results indicated that anxiety sensitivity, but not distress tolerance or discomfort intolerance, was significantly incrementally predictive of physical panic attack symptoms and cognitive panic attack symptoms. Additionally, anxiety sensitivity was significantly predictive of variance in panic attack status during the challenge. These findings emphasize the important, unique role of anxiety sensitivity in predicting risk for panic psychopathology, even when considered in the context of other theoretically relevant emotion vulnerability variables. PMID:19720496

  2. Covering Politics.

    ERIC Educational Resources Information Center

    Gruber, Ryan; Wind, Andrew; Trevidi, Neema

    2000-01-01

    Presents four articles considering: (1) the media's role in the coverage of politics; (2) the influence of photography particularly in terms of the president; (3) an event where an Iowa student had a chance to work with professionals while covering politics; and (4) considering scholastic reporters covering national candidates as they learn and…

  3. Relevancy 101

    NASA Technical Reports Server (NTRS)

    Lynnes, Chris; Newman, Doug

    2016-01-01

    Where we present an overview on why relevancy is a problem, how important it is and how we can improve it. The topic of relevancy is becoming increasingly important in earth data discovery as our audience is tuned to the accuracy of standard search engines like Google.

  4. Energy absorption buildup factors of human organs and tissues at energies and penetration depths relevant for radiotherapy and diagnostics.

    PubMed

    Manohara, S R; Hanagodimath, S M; Gerward, L

    2011-01-01

    Energy absorption geometric progression (GP) fitting parameters and the corresponding buildup factors have been computed for human organs and tissues, such as adipose tissue, blood (whole), cortical bone, brain (grey/white matter), breast tissue, eye lens, lung tissue, skeletal muscle, ovary, testis, soft tissue, and soft tissue (4-component), for the photon energy range 0.015-15 MeV and for penetration depths up to 40 mfp (mean free path). The chemical composition of human organs and tissues is seen to influence the energy absorption buildup factors. It is also found that the buildup factor of human organs and tissues changes significantly with the change of incident photon energy and effective atomic number, Z(eff). These changes are due to the dominance of different photon interaction processes in different energy regions and different chemical compositions of human organs and tissues. With the proper knowledge of buildup factors of human organs and tissues, energy absorption in the human body can be carefully controlled. The present results will help in estimating safe dose levels for radiotherapy patients and also useful in diagnostics and dosimetry. The tissue-equivalent materials for skeletal muscle, adipose tissue, cortical bone, and lung tissue are also discussed. It is observed that water and MS20 are good tissue equivalent materials for skeletal muscle in the extended energy range. PMID:22089011

  5. Are opossums a relevant factor associated with asymptomatic Leishmania infection in the outskirts of the largest Brazilian cities?

    PubMed

    Carranza-Tamayo, César Omar; Werneck, Guilherme Loureiro; Romero, Gustavo Adolfo Sierra

    2016-01-01

    A population survey was conducted to explore the prevalence and factors associated with Leishmania infection in the Fercal region of the Federal District. The Fercal region is a group of neighborhoods in Brasília in which the first cases of visceral leishmaniasis were described. Leishmania infection was established by a positive leishmanin test. Although other tests were performed in the study (an immunochromatographic assay (Kalazar detect(®)) and a molecular assay), only the leishmanin skin test provided sufficient results for the measurement of the disease prevalence. Data on the epidemiological, clinical and environmental characteristics of individuals were collected along with the diagnostic tests. After sampling and enrollment, seven hundred people from 2 to 14 years of age were included in the study. The prevalence of Leishmania infection was 33.28% (95% CI 29.87-36.84). The factors associated with Leishmania infection according to the multivariate analysis were age of more than seven years and the presence of opossums near the home. Age is a known factor associated with Leishmania infection; however, the presence of wild animals, as described, is an understudied factor. The presence of opossums, which are known reservoirs of Leishmania, in peri-urban areas could be the link between the rural and urban occurrence of visceral leishmaniasis in the outskirts of largest Brazilian cities, as suggested by previous studies. PMID:26867473

  6. AN ANALYSIS OF SELECTED FACTORS RELEVANT TO THE EMPLOYMENT STATUS IN BUSINESS OFFICES OF MARRIED WOMEN COLLEGE GRADUATES.

    ERIC Educational Resources Information Center

    BECK, ESTHER LILY

    AN ANALYSIS OF FACTORS THAT HINDERED OR IMPEDED THE OCCUPATIONAL ADVANCEMENT OF COLLEGE WOMEN WERE GROUPED AROUND THE FOUR AREAS OF PERSONAL AND SOCIOECONOMIC BACKGROUNDS, CHARACTERISTICS OF THE POSITIONS HELD BY THE WOMEN, BUSINESS POLICIES AND PRACTICES OF EMPLOYING FIRMS, AND POINTS OF VIEW EXPRESSED BY THE WOMEN ABOUT THEIR EXPERIENCES. DATA…

  7. Saharan dust as a causal factor of hemispheric asymmetry in aerosols and cloud cover over the tropical Atlantic Ocean

    SciTech Connect

    Kishcha, Pavel; Da Sliva, Arlindo; Starobinets, Boris; Long, Charles N.; Kalashnikova, Olga; Alpert, Pinhas

    2015-07-09

    Meridional distribution of aerosol optical thickness (AOT) over the tropical Atlantic Ocean (30°N – 30°S) was analyzed to assess seasonal variations of meridional AOT asymmetry. Ten-year MERRA Aerosol Reanalysis (MERRAero) data (July 2002 – June 2012) confirms that the Sahara desert emits a significant amount of dust into the atmosphere over the Atlantic Ocean. Only over the Atlantic Ocean did MERRAero show that desert dust dominates other aerosol species and is responsible for meridional aerosol asymmetry between the tropical North and South Atlantic. Over the 10-year period under consideration, both MISR measurements and MERRAero data showed a pronounced meridional AOT asymmetry. The meridional AOT asymmetry, characterized by the hemispheric ratio (RAOT) of AOT averaged separately over the North and over the South Atlantic, was about 1.7. Seasonally, meridional AOT asymmetry over the Atlantic was the most pronounced between March and July, when dust presence is maximal (RAOT ranged from 2 to 2.4). There was no noticeable meridional aerosol asymmetry in total AOT from September to October. During this period the contribution of carbonaceous aerosols to total AOT in the South Atlantic was comparable to the contribution of dust aerosols to total AOT in the North Atlantic. During the same 10-year period, MODIS cloud fraction (CF) data showed that there was no noticeable asymmetry in meridional CF distribution in different seasons (the hemispheric ratio of CF ranged from 1.0 to 1.2). MODIS CF data illustrated significant cloud cover (CF of 0.7 – 0.9) with limited precipitation ability along the Saharan Air Layer.

  8. Saharan dust as a causal factor of hemispheric asymmetry in aerosols and cloud cover over the tropical Atlantic Ocean

    DOE PAGESBeta

    Kishcha, Pavel; Da Sliva, Arlindo; Starobinets, Boris; Long, Charles N.; Kalashnikova, Olga; Alpert, Pinhas

    2015-07-09

    Meridional distribution of aerosol optical thickness (AOT) over the tropical Atlantic Ocean (30°N – 30°S) was analyzed to assess seasonal variations of meridional AOT asymmetry. Ten-year MERRA Aerosol Reanalysis (MERRAero) data (July 2002 – June 2012) confirms that the Sahara desert emits a significant amount of dust into the atmosphere over the Atlantic Ocean. Only over the Atlantic Ocean did MERRAero show that desert dust dominates other aerosol species and is responsible for meridional aerosol asymmetry between the tropical North and South Atlantic. Over the 10-year period under consideration, both MISR measurements and MERRAero data showed a pronounced meridional AOTmore » asymmetry. The meridional AOT asymmetry, characterized by the hemispheric ratio (RAOT) of AOT averaged separately over the North and over the South Atlantic, was about 1.7. Seasonally, meridional AOT asymmetry over the Atlantic was the most pronounced between March and July, when dust presence is maximal (RAOT ranged from 2 to 2.4). There was no noticeable meridional aerosol asymmetry in total AOT from September to October. During this period the contribution of carbonaceous aerosols to total AOT in the South Atlantic was comparable to the contribution of dust aerosols to total AOT in the North Atlantic. During the same 10-year period, MODIS cloud fraction (CF) data showed that there was no noticeable asymmetry in meridional CF distribution in different seasons (the hemispheric ratio of CF ranged from 1.0 to 1.2). MODIS CF data illustrated significant cloud cover (CF of 0.7 – 0.9) with limited precipitation ability along the Saharan Air Layer.« less

  9. Three factors causing the thermal efficiency of a heat engine to be less than unity and their relevance to daily life

    NASA Astrophysics Data System (ADS)

    Wu, Jing

    2015-01-01

    The thermal efficiency of a heat engine is of primary interest in introductory thermodynamics courses. This study presents a simple method to quantitatively distinguish the factors that cause the thermal efficiency of a heat engine to be less than unity. These factors are the nonzero reference point, external irreversibilities and internal irreversibilities. Next, the difference between the present method and the existing second-law efficiency method for evaluating the influence of irreversibility is discussed. Then, an example of an actual heat-engine cycle is given to demonstrate the feasibility and effectiveness of the presented method. Finally, some remarks on the relevance of the three factors to our attitude toward life are presented.

  10. Pharmacokinetic drug–drug interactions between 1,4-dihydropyridine calcium channel blockers and statins: factors determining interaction strength and relevant clinical risk management

    PubMed Central

    Zhou, Yi-Ting; Yu, Lu-Shan; Zeng, Su; Huang, Yu-Wen; Xu, Hui-Min; Zhou, Quan

    2014-01-01

    Background Coadministration of 1,4-dihydropyridine calcium channel blockers (DHP-CCBs) with statins (or 3-hydroxy-3-methylglutaryl-coenzyme A [HMG-CoA] reductase inhibitors) is common for patients with hypercholesterolemia and hypertension. To reduce the risk of myopathy, in 2011, the US Food and Drug Administration (FDA) Drug Safety Communication set a new dose limitation for simvastatin, for patients taking simvastatin concomitantly with amlodipine. However, there is no such dose limitation for atorvastatin for patients receiving amlodipine. The combination pill formulation of amlodipine/atorvastatin is available on the market. There been no systematic review of the pharmacokinetic drug–drug interaction (DDI) profile of DHP-CCBs with statins, the underlying mechanisms for DDIs of different degree, or the corresponding management of clinical risk. Methods The relevant literature was identified by performing a PubMed search, covering the period from January 1987 to September 2013. Studies in the field of drug metabolism and pharmacokinetics that described DDIs between DHP-CCB and statin or that directly compared the degree of DDIs associated with cytochrome P450 (CYP)3A4-metabolized statins or DHP-CCBs were included. The full text of each article was critically reviewed, and data interpretation was performed. Results There were three circumstances related to pharmacokinetic DDIs in the combined use of DHP-CCB and statin: 1) statin is comedicated as the precipitant drug (pravastatin–nimodipine and lovastatin–nicardipine); 2) statin is comedicated as the object drug (isradipine–lovastatin, lacidipine–simvastatin, amlodipine–simvastatin, benidipine-simvastatin, azelnidipine– simvastatin, lercanidipine–simvastatin, and amlodipine–atorvastatin); and 3) mutual interactions (lercanidipine–fluvastatin). Simvastatin has an extensive first-pass effect in the intestinal wall, whereas atorvastatin has a smaller intestinal first-pass effect. The interaction

  11. Sky cover

    NASA Astrophysics Data System (ADS)

    Gerth, Jordan J.

    Of all of the standard meteorological parameters collected and observed daily, sky cover is not only one of the most complex, but the one that is fairly ambiguously defined and difficult to quantify. Despite that, the implications of how cloud fraction and sky cover are understood not only impact daily weather forecasts, but also present challenges to assessing the state of the earth's climate system. Part of the reason for this is the lack of observational methods for verifying the skill of clouds represented and parameterized in numerical models. While human observers record sky cover as part of routine duties, the spatial coverage of such observations in the United States is relatively sparse. There is greater spatial coverage of automated observations, and essentially complete coverage from geostationary weather satellites that observe the Americas. A good analysis of sky cover reconciles differences between manual observations, automated observations, and satellite observations, through an algorithm that accounts for the strengths and weaknesses of each dataset. This work describes the decision structure for trusting and weighting these similar observations. Some of the issues addressed include: human and instrument error resulting from approximations and estimations, a deficiency in high cloud detectability using surface-based ceilometers, poorly resolved low cloud using infrared channels on space-based radiometers during overnight hours, and decreased confidence in satellite-detected cloud during stray light periods. Using the blended sky cover analysis as the best representation of cloudiness, it is possible to compare the analysis to numerical model fields in order to assess the performance of the model and the parameterizations therein, as well as confirm or uncover additional relationships between sky cover and pertinent fields using an optimization methodology. The optimizer minimizes an affine expression of adjusted fields to the "truth" sky cover

  12. Psychological Factors in Chronic Pelvic Pain in Women: Relevance and Application of the Fear-Avoidance Model of Pain

    PubMed Central

    Bishop, Mark D.

    2011-01-01

    Chronic pelvic pain in women is a debilitating, costly condition often treated by physical therapists. The etiology of this condition is multifactorial and poorly understood, given the complex interplay of muscles, bones, and soft tissue that comprise the pelvis. There are few guidelines directing treatment interventions for this condition. In the last decade, several investigators have highlighted the role of psychological variables in conditions such as vulvodynia and painful bladder syndrome. Pain-related fear is the focus of the fear-avoidance model (FAM) of pain, which theorizes that some people are more likely to develop and maintain pain after an injury because of their emotional and behavioral responses to pain. The FAM groups people into 2 classes on the basis of how they respond to pain: people who have low fear, confront pain, and recover from injury and people who catastrophize pain—a response that leads to avoidance/escape behaviors, disuse, and disability. Given the presence of pain-related cognitions in women with chronic pelvic pain, including hypervigilance, catastrophizing, and anxiety, research directed toward the application of the FAM to guide therapeutic interventions is warranted. Isolated segments of the FAM have been studied to theorize why traditional approaches (ie, medications and surgery) may not lead to successful outcomes. However, the explicit application of the FAM to guide physical therapy interventions for women with chronic pelvic pain is not routine. Integrating the FAM might direct physical therapists' clinical decision making on the basis of the pain-related cognitions and behaviors of patients. The aims of this article are to provide information about the FAM of musculoskeletal pain and to provide evidence for the relevance of the FAM to chronic pelvic pain in women. PMID:21835893

  13. Blood lead and cadmium levels and relevant factors among children from an e-waste recycling town in China

    SciTech Connect

    Zheng Liangkai; Wu Kusheng; Li Yan; Qi Zongli; Han Dai; Zhang Bao; Gu Chengwu; Chen Gangjian; Liu Junxiao; Chen Songjian; Xu Xijin; Huo Xia

    2008-09-15

    Background: Primitive electronic waste (e-waste) recycling is ongoing in Guiyu, and thus toxic heavy metals may keep on threatening to the health of local children. Some related factors may contribute to the elevation of blood lead levels (BLLs) or blood cadmium levels (BCLs). Objective: To investigate the children's BLLs and BCLs in Guiyu and Chendian as compare to discuss the effects of primitive e-waste recycling activities on children's health. Methods: Two hundred and seventy-eight children less than 8 years who lived in Guiyu and Chendian were observed, and their BLLs and BCLs were determined by graphite atomizer absorption spectrophotometer. Questionnaire survey for risk factors was also performed and data were analyzed using spearman correlation analyses and logistic regression analyses. Results: Children living in Guiyu had significantly higher BLLs and BCLs as compared with those living in Chendian (p<0.01). In Guiyu, 70.8% of children (109/154) had BLLs>10 {mu}g/dL, and 20.1% of children (31/154) had BCLs>2 {mu}g/L, compared with 38.7% of children (48/124) had BLLs>10 {mu}g/dL and 7.3% of children (9/124) had BCLs>2 {mu}g/L in Chendian (p<0.01, respectively). We also observed a significant increasing trend in BLLs with increasing age in Guiyu (p<0.01). Mean height of children in Guiyu was significantly lower than that in Chendian (p<0.01). The risk factors related to children's BLLs and BCLs mainly included father's engagement in the work related to e-waste, children's residence in Guiyu and the amount of time that children played outside near the road everyday. Conclusions: There are close relationships between the BLLs, BCLs in children and the primitive e-waste recycling activities in Guiyu. Environmental pollution, especially lead pollution, has threatened the health of children living around e-waste recycling site.

  14. Functionally Relevant Microsatellite Markers From Chickpea Transcription Factor Genes for Efficient Genotyping Applications and Trait Association Mapping

    PubMed Central

    Kujur, Alice; Bajaj, Deepak; Saxena, Maneesha S.; Tripathi, Shailesh; Upadhyaya, Hari D.; Gowda, C.L.L.; Singh, Sube; Jain, Mukesh; Tyagi, Akhilesh K.; Parida, Swarup K.

    2013-01-01

    We developed 1108 transcription factor gene-derived microsatellite (TFGMS) and 161 transcription factor functional domain-associated microsatellite (TFFDMS) markers from 707 TFs of chickpea. The robust amplification efficiency (96.5%) and high intra-specific polymorphic potential (34%) detected by markers suggest their immense utilities in efficient large-scale genotyping applications, including construction of both physical and functional transcript maps and understanding population structure. Candidate gene-based association analysis revealed strong genetic association of TFFDMS markers with three major seed and pod traits. Further, TFGMS markers in the 5′ untranslated regions of TF genes showing differential expression during seed development had higher trait association potential. The significance of TFFDMS markers was demonstrated by correlating their allelic variation with amino acid sequence expansion/contraction in the functional domain and alteration of secondary protein structure encoded by genes. The seed weight-associated markers were validated through traditional bi-parental genetic mapping. The determination of gene-specific linkage disequilibrium (LD) patterns in desi and kabuli based on single nucleotide polymorphism-microsatellite marker haplotypes revealed extended LD decay, enhanced LD resolution and trait association potential of genes. The evolutionary history of a strong seed-size/weight-associated TF based on natural variation and haplotype sharing among desi, kabuli and wild unravelled useful information having implication for seed-size trait evolution during chickpea domestication. PMID:23633531

  15. Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization.

    PubMed Central

    Petersen, Steen V; Valnickova, Zuzana; Enghild, Jan J

    2003-01-01

    Pigment epithelium-derived factor (PEDF) inhibits the formation of blood vessels in the eye by inducing apotosis in actively dividing endothelial cells. The activity of PEDF equals or supersedes that of other anti-angiogenic factors, including angiostatin, endostatin and thrombospondin-1. In addition, PEDF has the potential to promote the survival of neurons and affect their differentiation. Here we show that PEDF is present in plasma at a concentration of approx. 100 nM (5 microg/ml) or twice the level required to inhibit aberrant blood-vessel growth in the eye. Thus the systemic delivery of PEDF has the potential to affect angiogenesis or neurotrophic processes throughout the body, significantly expanding the putative physiological role of the protein. A complete map of all post-translational modifications revealed that authentic plasma PEDF carries an N-terminal pyroglutamate blocking group and an N-linked glycan at position Asn266. The pyroglutamate residue may regulate the activity of PEDF analogously to the manner in which it regulates thyrotropin-releasing hormone. PMID:12737624

  16. Retina-derived POU domain factor 1 coordinates expression of genes relevant to renal and neuronal development.

    PubMed

    Fiorino, Antonio; Manenti, Giacomo; Gamba, Beatrice; Bucci, Gabriele; De Cecco, Loris; Sardella, Michele; Buscemi, Giacomo; Ciceri, Sara; Radice, Maria T; Radice, Paolo; Perotti, Daniela

    2016-09-01

    Retina-derived POU domain Factor 1 (RPF-1), a member of POU transcription factor family, is encoded by POU6F2 gene, addressed by interstitial deletions at chromosome 7p14 in Wilms tumor (WT). Its expression has been detected in developing kidney and nervous system, suggesting an early role for this gene in regulating development of these organs. To investigate into its functions and determine its role in transcriptional regulation, we generated an inducible stable transfectant from HEK293 cells. RPF-1 showed nuclear localization, elevated stability, and transactivation of promoters featuring POU consensus sites, and led to reduced cell proliferation and in vivo tumor growth. By addressing the whole transcriptome regulated by its induction, we could detect a gross alteration of gene expression that is consistent with promoter occupancy predicted by genome-wide Chip-chip analysis. Comparison of bound regulatory regions with differentially expressed genes allowed identification of 217 candidate targets. Enrichment of divergent octamers in predicted regulatory regions revealed promiscuous binding to bipartite POUS and POUH consensus half-sites with intervening spacers. Gel-shift competition assay confirmed the specificity of RPF-1 binding to consensus motifs, and demonstrated that the Ser-rich region upstream of the POU domain is indispensable to achieve DNA-binding. Promoter-reporter activity addressing a few target genes indicated a dependence by RPF-1 on transcriptional response. In agreement with its expression in developing kidney and nervous system, the induced transcriptome appears to indicate a function for this protein in early renal differentiation and neuronal cell fate, providing a resource for understanding its role in the processes thereby regulated. PMID:27425396

  17. DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer.

    PubMed

    Kurfurstova, Daniela; Bartkova, Jirina; Vrtel, Radek; Mickova, Alena; Burdova, Alena; Majera, Dusana; Mistrik, Martin; Kral, Milan; Santer, Frederic R; Bouchal, Jan; Bartek, Jiri

    2016-06-01

    The DNA damage checkpoints provide an anti-cancer barrier in diverse tumour types, however this concept has remained unexplored in prostate cancer (CaP). Furthermore, targeting DNA repair defects by PARP1 inhibitors (PARPi) as a cancer treatment strategy is emerging yet requires suitable predictive biomarkers. To address these issues, we performed immunohistochemical analysis of multiple markers of DNA damage signalling, oxidative stress, DNA repair and cell cycle control pathways during progression of human prostate disease from benign hyperplasia, through intraepithelial neoplasia to CaP, complemented by genetic analyses of TMPRSS2-ERG rearrangement and NQO1, an anti-oxidant factor and p53 protector. The DNA damage checkpoint barrier (γH2AX, pATM, p53) mechanism was activated during CaP tumorigenesis, albeit less and with delayed culmination compared to other cancers, possibly reflecting lower replication stress (slow proliferation despite cases of Rb loss and cyclin D1 overexpression) and progressive loss of ATM activator NKX3.1. Oxidative stress (8-oxoguanine lesions) and NQO1 increased during disease progression. NQO1 genotypes of 390 men did not indicate predisposition to CaP, yet loss of NQO1 in CaP suggested potential progression-opposing tumour suppressor role. TMPRSS2-ERG rearrangement and PTEN loss, events sensitizing to PARPi, occurred frequently along with heterogeneous loss of DNA repair factors 53BP1, JMJD1C and Rev7 (all studied here for the first time in CaP) whose defects may cause resistance to PARPi. Overall, our results reveal an unorthodox DNA damage checkpoint barrier scenario in CaP tumorigenesis, and provide novel insights into oxidative stress and DNA repair, with implications for biomarker guidance of future targeted therapy of CaP. PMID:26987799

  18. Modelling and measuring the spectral bidirectional reflectance factor of snow-covered sea ice: an intercomparison study

    NASA Astrophysics Data System (ADS)

    Li, Shusun; Zhou, Xiaobing

    2004-12-01

    Broadband albedo is a very important geophysical parameter in the Earth surface-atmosphere interaction in either global climate change or hydrological cycle and snowmelt runoff studies. To derive the broadband albedo accurately from satellite optical sensor observation at limited bands and at a single observation angle, the bidirectional reflectance factor (BRF) has to be specified quantitatively. In the present albedo derivation algorithms from the satellite radiance data, the BRF is either modelled or observed. Questions may arise as to how well a BRF model can be in the broadband albedo derivation. To help answer such questions, we studied the performance of a snow-surface BRF model for two specific cases under large solar zenith angles (65° and 85°). We measured snow-surface spectral directional reflectance under clear skies. The snow physical properties, such as snow grain size and snow density, at the same sites were also measured. In situ snow physical data are used to simulate the snow-surface BRF and hemispherical directional reflectance factor (HDRF) through a multilayered azimuth- and zenith-dependent plane-parallel radiative transfer model. The field measurements and BRF and HDRF simulations all reveal the forward-scattering nature of snow surface under large solar incidence angles, but the BRF model results depict the strongest forward-scattering patterns under such solar zenith angles. Because the HDRF is simulated through coupling of the surface BRF with radiative transfer in the atmosphere, the resulting HDRF patterns agree with the field measurements better than the simulated BRF does. The deviation of the simulated HDRF from field-based clear-sky directional reflectance (FCDR) is within +/-10% for the central (viewing zenith angle <45° ) and lateral sides of the viewing hemisphere. This level of agreement between the simulated HDRF and FCDR also implies that the simulated BRF model can provide remote-sensing estimates of spectral albedo

  19. Effective activation of antioxidant system by immune-relevant factors reversely correlates with apoptosis of Eisenia andrei coelomocytes.

    PubMed

    Homa, J; Stalmach, M; Wilczek, G; Kolaczkowska, E

    2016-05-01

    Oxidative stress is harmful to the microbes but also to the host, and may result in bystander damage or death. Because of this, respiratory burst triggered in phagocytes by pathogens is counteracted by production of antioxidative factors. The aim of this work was to examine effectiveness of the latter system in earthworms Eisenia andrei by induction of reactive oxygen species, lipofuscin and phenoloxidase by natural (LPS, zymosan, Micrococus luteus) and synthetic (phorbol ester, PMA) stimulants. The compounds impaired numbers, viability (increased apoptosis) and composition of coelomocytes, and triggered the antioxidant activity of catalase and selenium-dependent glutathione peroxidase. The natural pathogenic compounds, unlike PMA, strongly activated antioxidative responses that diminished cell apoptosis. Moreover, repeated exposure to the same or different pathogenic compounds did not induce respiratory burst exhausted phenotype showing that coelomocytes are constantly at bay to withstand numerous infections. The current study reveals importance and efficiency of the oxidative-antioxidative systems in annelids but also confirms its evolutionary conservatism and complexity even in lower taxa of the animal kingdom. PMID:26922789

  20. Combined incineration of industrial wastes with in-plant residues in fluidized-bed utility boilers--decision relevant factors.

    PubMed

    Ragossnig, Arne M; Lorber, Karl E

    2005-10-01

    In Austria more than 50% of the high-calorific industrial residues and wastes generated are utilized for energy recovery in industrial utility boilers. This study investigated full-scale trials of combined incineration of in-plant residues with various industrial wastes. These trials were carried out in order to learn how the alternatively used fuel influences the incineration process itself as well as the quantity and quality of the various incineration products. The currently used fuel, which consisted of in-plant residues as well as externally acquired waste wood and the refuse-derived fuel (RDF) mixtures used during the full-scale trials are characterized in terms of material composition as well as chemical and physical parameters. An input-output mass balance for the incineration plant (two fluidized bed combustion units, 20 and 30 MW, respectively) has been established, based on the data collected during the full-scale incineration trials. Furthermore, pollutant concentrations in the off-gas as well as the solid incineration residue are reported. It is not only the pollutant content but also a variety of other internal as well as external factors that have to be considered if a company is to decide whether or not to thermally utilize specific waste types. Therefore a strengths and weaknesses profile for several types of waste and the specific industrial boiler is also presented. PMID:16273953

  1. Relevance of psychosocial factors to quality of life in oral cancer and oral lichen planus: a prospective comparative study.

    PubMed

    Rana, Madiha; Kanatas, Anastasios; Herzberg, Philipp Y; Gellrich, Nils-Claudius; Rana, Majeed

    2015-09-01

    We can improve our understanding of how patients cope with oral squamous cell carcinoma (SCC) by making a comparison with their processes of coping and those used in other conditions. We have therefore compared quality of life (QoL), severity of symptoms, coping strategies, and factors that influence coping between patients with oral SCC and those with oral lichen planus. We asked 104 patients with oral SCC and 51 with oral lichen planus to complete questionnaires about their coping strategies, social support, locus of control, spirituality, QoL, and severity of symptoms. The outcome was that patients with oral SCC were far more likely to resort to coping strategies such as depressive coping, distraction, and self-motivation. The groups also differed regarding QoL and severity of symptoms. Patients with oral SCC had a poorer QoL and higher depression scores, whereas patients with oral lichen planus had better scores in the social support and spirituality categories. Patients with oral SCC generally had more distress than those with oral lichen planus. Not only did the former resort to depressive coping strategies, but they also had poorer QoL and higher values for depression. For the patients with oral lichen planus, social support and spirituality were protective, whereas they were associated with distress by patients with oral SCC. PMID:26004933

  2. Variability and reduced performance of preschool- and early school-aged children on psychoacoustic tasks: What are the relevant factors?

    NASA Astrophysics Data System (ADS)

    Allen, Prudence

    2003-04-01

    Young children typically perform more poorly on psychoacoustic tasks than do adults, with large individual differences. When performance is averaged across children within age groups, the data suggest a gradual change in performance with increasing age. However, an examination of individual data suggests that the performance matures more rapidly, although at different times for different children. The mechanisms of development responsible for these changes are likely very complex, involving both sensory and cognitive processes. This paper will discuss some previously suggested mechanisms including attention and cue weighting, as well as possibilities suggested from more recent studies in which learning effects were examined. In one task, a simple frequency discrimination was required, while in another the listener was required to extract regularities in complex sequences of sounds that varied from trial to trial. Results suggested that the ability to select and consistently employ an effective listening strategy was especially important in the performance of the more complex task, while simple stimulus exposure and motivation contributed to the simpler task. These factors are important for understanding the perceptual development and for the subsequent application of psychoacoustic findings to clinical populations. [Work supported by the NSERC and the Canadian Language and Literacy Research Network.

  3. Insulin-like growth factor-I as a candidate metabolic biomarker: military relevance and future directions for measurement.

    PubMed

    Nindl, Bradley C

    2009-03-01

    Insulin-like growth factor (IGF)-I is a ubiquitous peptide hormone involved in a host of critical physiological processes (e.g., protein synthesis and glucose homeostasis) and has been suggested to be a biomarker reflecting health and metabolic status. In most cases (muscle, bone, tendon, body composition, and cognitive function), elevated IGF-I concentrations are considered beneficial; however, cancer remains a notable exception. While the fact that both increased and decreased IGF-I can be considered reflective of favorable and beneficial health outcomes may appear as a paradox, it is important to emphasize that, in both cases, measured IGF-I concentrations do offer important insight into physiological processes. The effects of military operational field training on the circulating IGF-I system are discussed within the context of novel measurement technologies that (1) are field expedient and (2) provide more meaningful information. Prospective experimental approaches involving physical activity that sample and measure IGF-I in the body's various biocompartments will provide greater insight into the complex role that IGF-I possesses. Minimally invasive technologies that are field expedient, cost-effective, and allow for continuous and real-time feedback will have the greatest likelihood of being adapted and used in military environments. PMID:20144370

  4. Wall Covering

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The attractive wall covering shown below is one of 132 styles in the Mirror Magic II line offered by The General Tire & Rubber Company, Akron, Ohio. The material is metallized plastic fabric, a spinoff from space programs. Wall coverings are one of many consumer applications of aluminized plastic film technology developed for NASA by a firm later bought by King-Seeley Thermos Company, Winchester, Massachusetts, which now produces the material. The original NASA use was in the Echo 1 passive communications satellite, a "space baloon" made of aluminized mylar; the high reflectivity of the metallized coating enabled relay of communications signals from one Earth station to another by "bouncing" them off the satellite. The reflectivity feature also made the material an extremely efficient insulator and it was subsequently widely used in the Apollo program for such purposes as temperature control of spacecraft components and insulation of tanks for fuels that must be maintained at very low temperatures. I Used as a wall covering, the aluminized material offers extra insulation, reflects light and I resists cracking. In addition to General Tire, King-Seeley also supplies wall covering material to Columbus Coated Fabrics Division of Borden, Incorporated, Columbus, Ohio, among others.

  5. Cover Crops

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cover crops are great tools to improve soil quality and health, and great tools to increase carbon sequestration. They are nutrient management tools that can help scavenge nitrate, cycle nitrogen to the following crop, mine NO3 from groundwater, and increase nitrogen use efficiency of cropping syste...

  6. Identification of multiple cellular uptake pathways of polystyrene nanoparticles and factors affecting the uptake: relevance for drug delivery systems.

    PubMed

    Firdessa, Rebuma; Oelschlaeger, Tobias A; Moll, Heidrun

    2014-01-01

    Nanoparticles may address challenges by human diseases through improving diagnosis, vaccination and treatment. The uptake mechanism regulates the type of threat a particle poses on the host cells and how a cell responds to it. Hence, understanding the uptake mechanisms and cellular interactions of nanoparticles at the cellular and subcellular level is a prerequisite for their effective biomedical applications. The present study shows the uptake mechanisms of polystyrene nanoparticles and factors affecting their uptake in bone marrow-derived macrophages, 293T kidney epithelial cells and L929 fibroblasts. Labeling with the endocytic marker FM4-64 and transmission electron microscopy studies show that the nanoparticles were internalized rapidly via endocytosis and accumulated in intracellular vesicles. Soon after their internalizations, nanoparticles trafficked to organelles with acidic pH. Analysis of the ultrastructural morphology of the plasma membrane invaginations or extravasations provides clear evidence for the involvement of several uptake routes in parallel to internalize a given type of nanoparticles by mammalian cells, highlighting the complexity of the nanoparticle-cell interactions. Blocking the specific endocytic pathways by different pharmacological inhibitors shows similar outcomes. The potential to take up nanoparticles varies highly among different cell types in a particle sizes-, time- and energy-dependent manner. Furthermore, infection and the activation status of bone marrow-derived macrophages significantly affect the uptake potential of the cells, indicating the need to understand the diseases' pathogenesis to establish effective and rational drug-delivery systems. This study enhances our understanding of the application of nanotechnology in biomedical sciences. PMID:25224362

  7. Behavior of Shiga toxigenic Escherichia coli relevant to lettuce washing processes and consideration of factors for evaluating washing process surrogates.

    PubMed

    Deng, Kaiping; Wang, Xue; Yen, Li-Han; Ding, Hongliu; Tortorello, Mary Lou

    2014-11-01

    Postharvest processes for fresh produce commonly include washing in water containing antimicrobial chemicals, such as chlorine; however, if the antimicrobials are not present in sufficient levels, washing can promote the spread of contamination that might be present. To understand cross-contamination risk during washing, we tested a collection of Shiga toxigenic Escherichia coli (STEC), including O157:H7 and other non-O157 strains, for certain traits during washing of fresh-cut lettuce, i.e., sensitivity to sublethal chlorine levels and ability to cross-contaminate (detach from and attach to) lettuce in the presence of sublethal chlorine levels. Nonpathogenic E. coli Nissle 1917 (EcN) and Pediococcus pentosaceus lactic acid bacterial species (LAB) were included as potential washing process validation surrogates. As measured by extension of the lag phase of growth in media containing 0.15 ppm of chlorine, chlorine sensitivity varied among the STECs. Cross-contamination was assessed by evaluating transfer of bacteria from inoculated to uninoculated leaves during washing. Without chlorine, similar transfer to wash water and uninoculated leaves was shown. In 1 ppm of chlorine, cross-contamination was not detected with most strains, except for the substantial transfer by a STEC O111 strain and EcN in some replicates. Strain O111 and EcN showed less inactivation in 0.25 ppm of chlorine water compared with O157 (P < 0.05). LAB showed similar transfer and similar chlorine inactivation to O157. Considering together the sublethal chlorine sensitivity and detachment/attachment traits, neither EcN nor LAB displayed optimal characteristics as washing process surrogates for the STEC strains, although further evaluation is needed. This work demonstrated a range of behaviors of STEC strains during lettuce washing and may be helpful in hazard characterization, identifying factors to consider for evaluating washing process efficacy, and identifying phenotypic traits to select

  8. CTLA-4 in mesothelioma patients: tissue expression, body fluid levels and possible relevance as a prognostic factor.

    PubMed

    Roncella, Silvio; Laurent, Stefania; Fontana, Vincenzo; Ferro, Paola; Franceschini, Maria Cristiana; Salvi, Sandra; Varesano, Serena; Boccardo, Simona; Vigani, Antonella; Morabito, Anna; Canessa, Pier Aldo; Giannoni, Ugo; Rosenberg, Ilan; Valentino, Alessandro; Fedeli, Franco; Merlo, Domenico Franco; Ceppi, Marcello; Riggio, Salvatore; Romani, Massimo; Saverino, Daniele; Poggi, Alessandro; Pistillo, Maria Pia

    2016-08-01

    CTLA-4 function as a negative regulator of T cell-mediated immune response is well established, whereas much less is known about the immunoregulatory role of its soluble isoform (sCTLA-4). No data are available on CTLA-4 expression and prognostic impact in malignant pleural mesothelioma (MPM). We investigated, by immunohistochemistry, CTLA-4 expression in tumor tissues and, by ELISA, sCTLA-4 levels in sera and matched pleural effusions from 45 MPM patients. Prognostic effect of CTLA-4 expression on overall survival (OS) was assessed through Cox regression and prognostic significance expressed as death rate ratio (HR). We found that 56.0 % of MPM tissues expressed CTLA-4 with variable intensity and percentage of positive cells estimated by the immunoreactive score. sCTLA-4 levels were significantly higher in sera (S-sCTLA-4) than in pleural effusions (PE-sCTLA-4) (geometric mean ratio = 2.70, P value = 0.020). CTLA-4 expression at the tissue level was higher in the epithelioid histological subtype than in the sarcomatoid, whereas at the serum level, it was higher in the sarcomatoid subtype. A homogeneous favorable prognostic effect was found for CTLA-4 overexpression in tissue, serum and pleural effusion. Interestingly, only the PE-sCTLA-4 was found to be a statistically significant positive prognostic factor (HR = 0.37, 95 % CI = 0.18-0.77, P value = 0.007). Indeed, PE-sCTLA-4 correlated with CTLA-4 expression in tissues, whereas this latter expression showed a weak association with OS. To confirm our findings, further experimental evidences obtained from a larger cohort of MPM patients are required. However, our results would indicate a positive correlation of PE-sCTLA-4 levels and OS in MPM patients. PMID:27207606

  9. Why are women so intelligent? The effect of maternal IQ on childhood mortality may be a relevant evolutionary factor.

    PubMed

    Charlton, Bruce G

    2010-03-01

    Humans are an unusual species because they exhibit an economic division of labour. Most theories concerning the evolution of specifically human intelligence have focused either on economic problems or sexual selection mechanisms, both of which apply more to men than women. Yet while there is evidence for men having a slightly higher average IQ, the sexual dimorphism of intelligence is not obvious (except at unusually high and low levels). However, a more female-specific selection mechanism concerns the distinctive maternal role in child care during the offspring's early years. It has been reported that increasing maternal intelligence is associated with reducing child mortality. This would lead to a greater level of reproductive success for intelligent women, and since intelligence is substantially heritable, this is a plausible mechanism by which natural selection might tend to increase female intelligence in humans. Any effect of maternal intelligence on improving child survival would likely be amplified by assortative mating for IQ by which people tend to marry others of similar intelligence - combining female maternal and male economic or sexual selection factors. Furthermore, since general intelligence seems to have the functional attribute of general purpose problem-solving and more rapid learning, the advantages of maternal IQ are likely to be greater as the environment for child-rearing is more different from the African hunter-gatherer society and savannah environment in which ancestral humans probably evolved. However, the effect of maternal IQ on child mortality would probably only be of major evolutionary significance in environments where childhood mortality rates were high. The modern situation is that population growth is determined mostly by birth rates; so in modern conditions, maternal intelligence may no longer have a significant effect on reproductive success; the effect of female IQ on reproductive success is often negative. Nonetheless, in the

  10. Emerging factors associated with the decline of a gray fox population and multi-scale land cover associations of mesopredators in the Chicago metropolitan area.

    SciTech Connect

    Willingham, Alison N.; /Ohio State U.

    2008-01-01

    mortality due to coyote predation was documented and disease was a major mortality source for foxes. The declining relative abundance of gray fox in Illinois is likely a result of a combination of factors. Assessment of habitat associations indicated that urban mesopredators, particularly coyotes and foxes, perceived the landscape as relatively homogeneous and that urban mesopredators interacted with the environment at scales larger than that accommodated by remnant habitat patches. Coyote and fox presence was found to be associated with a high degree of urban development at large and intermediate spatial scales. However, at a small spatial scale fox presence was associated with high density urban land cover whereas coyote presence was associated with urban development with increased forest cover. Urban habitats can offer a diversity of prey items and anthropogenic resources and natural land cover could offer coyotes daytime resting opportunities in urban areas where they may not be as tolerated as smaller foxes. Raccoons and opossums were found to utilize moderately developed landscapes with interspersed natural and semi-natural land covers at a large spatial scale, which may facilitate dispersal movements. At intermediate and small spatial scales, both species were found to utilize areas that were moderately developed and included forested land cover. These results indicated that raccoons and opossums used natural areas in proximity to anthropogenic resources. At a large spatial scale, skunk presence was associated with highly developed landscapes with interspersed natural and semi-natural land covers. This may indicate that skunks perceived the urban matrix as more homogeneous than raccoons or opossums. At an intermediate spatial scale skunks were associated with moderate levels of development and increased forest cover, which indicated that they might utilize natural land cover in proximity to human-dominated land cover. At the smallest spatial scale skunk presence was

  11. Environmental factors and public health policy associated with human and rodent infection by leptospirosis: a land cover-based study in Nan province, Thailand.

    PubMed

    Della Rossa, P; Tantrakarnapa, K; Sutdan, D; Kasetsinsombat, K; Cosson, J-F; Supputamongkol, Y; Chaisiri, K; Tran, A; Supputamongkol, S; Binot, A; Lajaunie, C; Morand, S

    2016-05-01

    Leptospirosis incidence has increased markedly since 1995 in Thailand, with the eastern and northern parts being the most affected regions, particularly during flooding events. Here, we attempt to overview the evolution of human prevalence during the past decade and identify the environmental factors that correlate with the incidence of leptospirosis and the clinical incidence in humans. We used an extensive survey of Leptospira infection in rodents conducted in 2008 and 2009 and the human incidence of the disease from 2003 to 2012 in 168 villages of two districts of Nan province in Northern Thailand. Using an ad-hoc developed land-use cover implemented in a geographical information system we showed that humans and rodents were not infected in the same environment/habitat in the land-use cover. High village prevalence was observed in open habitat near rivers for the whole decade, or in 2008-2009 mostly in rice fields prone to flooding, whereas infected rodents (2008-2009) were observed in patchy habitat with high forest cover, mostly situated on sloping ground areas. We also investigated the potential effects of public health campaigns conducted after the dramatic flood event of 2006. We showed that, before 2006, human incidence in villages was explained by the population size of the village according to the environmental source of infection of this disease, while as a result of the campaigns, human incidence in villages after 2006 appeared independent of their population size. This study confirms the role of the environment and particularly land use, in the transmission of bacteria, emphasized by the effects of the provincial public health campaigns on the epidemiological pattern of incidence, and questions the role of rodents as reservoirs. PMID:26607833

  12. Improved Variable Selection Algorithm Using a LASSO-Type Penalty, with an Application to Assessing Hepatitis B Infection Relevant Factors in Community Residents

    PubMed Central

    Guo, Pi; Zeng, Fangfang; Hu, Xiaomin; Zhang, Dingmei; Zhu, Shuming; Deng, Yu; Hao, Yuantao

    2015-01-01

    Objectives In epidemiological studies, it is important to identify independent associations between collective exposures and a health outcome. The current stepwise selection technique ignores stochastic errors and suffers from a lack of stability. The alternative LASSO-penalized regression model can be applied to detect significant predictors from a pool of candidate variables. However, this technique is prone to false positives and tends to create excessive biases. It remains challenging to develop robust variable selection methods and enhance predictability. Material and methods Two improved algorithms denoted the two-stage hybrid and bootstrap ranking procedures, both using a LASSO-type penalty, were developed for epidemiological association analysis. The performance of the proposed procedures and other methods including conventional LASSO, Bolasso, stepwise and stability selection models were evaluated using intensive simulation. In addition, methods were compared by using an empirical analysis based on large-scale survey data of hepatitis B infection-relevant factors among Guangdong residents. Results The proposed procedures produced comparable or less biased selection results when compared to conventional variable selection models. In total, the two newly proposed procedures were stable with respect to various scenarios of simulation, demonstrating a higher power and a lower false positive rate during variable selection than the compared methods. In empirical analysis, the proposed procedures yielding a sparse set of hepatitis B infection-relevant factors gave the best predictive performance and showed that the procedures were able to select a more stringent set of factors. The individual history of hepatitis B vaccination, family and individual history of hepatitis B infection were associated with hepatitis B infection in the studied residents according to the proposed procedures. Conclusions The newly proposed procedures improve the identification of

  13. Compromising σ-1 Receptors at the Endoplasmic Reticulum Render Cytotoxicity to Physiologically Relevant Concentrations of Dopamine in a Nuclear Factor-κB/Bcl-2-Dependent Mechanism: Potential Relevance to Parkinson's Disease

    PubMed Central

    Mori, Tomohisa; Hayashi, Teruo

    2012-01-01

    The endoplasmic reticulum (ER) chaperone σ-1 receptor (Sig-1R) is cytoprotective against ER stress-induced apoptosis. The level of Sig-1Rs in the brain was reported to be lower in early parkinsonian patients. Because dopamine (DA) toxicity is well known to be involved in the etiology of Parkinson's disease, we tested in this study whether a relationship might exist between Sig-1Rs and DA-induced cytotoxicity in a cellular model by using Chinese hamster ovary (CHO) cells. DA in physiological concentrations (e.g., lower than 10 μM) does not cause apoptosis. However, the same concentrations of DA cause apoptosis in Sig-1R knockdown CHO cells. In search of a mechanistic explanation, we found that unfolded protein response is not involved. Rather, the level of protective protein Bcl-2 is critically involved in this DA/Sig-1R knockdown-induced apoptosis. Specifically, the DA/Sig-1R knockdown causes a synergistic proteasomal conversion of nuclear factor κB (NF-κB) p105 to the active form of p50, which is known to down-regulate the transcription of Bcl-2. It is noteworthy that the DA/Sig-1R knockdown-induced apoptosis is blocked by the overexpression of Bcl-2. Our results therefore indicate that DA is involved in the activation of NF-κB and suggest that endogenous Sig-1Rs are tonically inhibiting the proteasomal conversion/activation of NF-κB caused by physiologically relevant concentrations of DA that would otherwise cause apoptosis. Thus, Sig-1Rs and associated ligands may represent new therapeutic targets for the treatment of parkinsonism. PMID:22399814

  14. That's why I take my ONS. Means-end chain as a novel approach to elucidate the personally relevant factors driving ONS consumption in nutritionally frail elderly users.

    PubMed

    den Uijl, Louise C; Kremer, Stefanie; Jager, Gerry; van der Stelt, Annelies J; de Graaf, Cees; Gibson, Peter; Godfrey, James; Lawlor, J Ben

    2015-06-01

    Oral nutritional supplements (ONS) are a recommended form of nutritional intervention for older malnourished persons when a 'food first' approach and/or food fortification prove ineffective. The efficacy of ONS will depend on, amongst other factors, whether persons do, or do not, consume their prescribed amount. Factors influencing ONS consumption can be product, context, or person related. Whereas product and context have received some attention, little is known about the person factors driving ONS consumption. In addition, the relative importance of the product, context, and person factors to ONS consumption is not known. Using the means-end chain (MEC) method, the current study elucidated personally relevant factors (product, context, and person factors) related to ONS consumption in two groups of older nutritionally frail ONS users: community-dwelling persons and care home residents with mainly somatic disorders. To our knowledge, the current work is the first to apply the MEC method to study older nutritionally frail ONS users. Forty ONS users (n = 20 per group) were recruited via healthcare professionals. The level of frailty was assessed using the FRAIL scale. Both groups were interviewed for 30 to 45 minutes using the soft laddering technique. The laddering data were analysed using LadderUX software™. The MEC method appeared to work well in both groups. The majority of the participants took ONS on their doctor's or dietician's prescription as they trusted their advice. The community-dwelling group took ONS to prolong their independence, whereas the care home group reported values that related more to small improvements in quality of life. In addition, care home residents perceived themselves as dependent on their caregiver for their ONS arrangements, whereas this dependence was not reported by community-dwelling persons. Key insights from this work will enable doctors and dieticians to customize their nutritional interventions to ONS users' personal

  15. Thresholds controlling shifts in forest cover types in the boreal region of Interior Alaska: inter- actions between climate, fire and edaphic factors

    NASA Astrophysics Data System (ADS)

    Kasischke, E. S.; Johnstone, J. F.; Rupp, S.; Duffy, P. A.; Kielland, K.; Chapin, F. S.

    2007-12-01

    There is a general consensus that future warming in the North American Boreal Region will cause a reduction in coniferous species common to cool, wet sites and an increase in deciduous/coniferous species found on warmer drier sites. In addition, it is believed that much of the change in forest cover will occur during secondary succession following disturbance and that the frequency of disturbance is likely to increase in response to climate warming; however, neither the rate at forest cover will change, nor the mechanisms thereof are well understood. Here, we summarize results from recent studies in Alaska that are being carried out as part of the Bonanza Creek Long Term Ecological Research Project and research being funded by the Joint Fire Science Program and NASA. We have examined factors important in regulating the change in the extent of black spruce (Picea mariana), a dominant forest type across the North American boreal region. Depth of burning of the surface organic layer is a fire severity measure that is important in regulating the post-fire environment in black spruce forests. In particular, seeds from deciduous trees have extremely low germination rates in post-fire organic soils that are greater than 3 cm deep. In addition, we found the growth of deciduous species in burned stands is inversely proportional to the depth of the remaining organic soil, with the highest growth observed on sites with exposed mineral soils. Other factors controlling seedling survival and growth include soil temperature and moisture, nutrient availability, and the fact that deciduous and coniferous species have different capabilities in absorbing different forms of soil nitrogen. These additional factors are also controlled by the amount of organic soil remaining after the fire. Finally, our research has shown that the depth of the remaining organic soil after fires is controlled both by topography and climate, with the frequency of sites with organic layers shallower than 3

  16. Cover Picture.

    PubMed

    Krömer; Rios-Carreras; Fuhrmann; Musch; Wunderlin; Debaerdemaeker; Mena-Osteritz; Bäuerle

    2000-10-01

    The cover picture shows the synthesis of novel conjugated macrocycles assembled from oligothiophenes bearing terminal acetylene groups. Under pseudo-high-dilution conditions the oxidative cyclooligomerization first gives the oligothiophenediynes, the precursors to the new class of alpha-cyclo[n]thiophenes. The detailed structure of macrocycles with up to 76 ring members and cavities of up to 3 nm could be investigated by means of X-ray structure analysis, scanning tunneling microscopy, and quantum chemical calculations (see the molecular model top right). The novel rings combine the excellent electronic properties of the corresponding linearly conjugated oligomers with the possibility of complexing large organic guest molecules or other objects (the tower of the Cathedral at Ulm represents a nanometer-sized, rodlike entity), which should have new fundamental properties and applications. The background shows the image obtained by scanning electron microscopy of a self-assembled and perfectly ordered monolayer of macrocycles on a graphite surface. More on these fascinating nanometer-sized rings can be found in the communication by P. Bäuerle et al. on p. 3481 ff. PMID:11091367

  17. A new approach to estimate cover-management factor of RUSLE and validation of RUSLE model in the watershed of Kartalkaya Dam

    NASA Astrophysics Data System (ADS)

    Tanyaş, Hakan; Kolat, Çağıl; Süzen, M. Lütfi

    2015-09-01

    RUSLE is one of the most widely used soil erosion model worldwide. However, some of the input parameters of RUSLE may require extensive field and laboratory studies, and therefore in most of the cases these parameters are estimated according to some alternative approaches. In this context, cover-management factor (C) has significant importance since it is the most influential factor due to its effect on result, besides; there are some doubts about the alternative approaches which are used to estimate the C factor. Moreover, although plenty of RUSLE applications in different areas are conducted in Turkey, any comprehensive study regarding the validation of obtained RUSLE results according to specific conditions is lacking. In this study, the drainage basin of the reservoir of Kartalkaya Dam which is in the south eastern part of Turkey was chosen as the study area, and the average annual eroded material was identified though RUSLE. For the mentioned reservoir area, the availability of bathymetry measurements for 30 years time span between 1975-2005, provide the appropriate conditions to validate the results of the model since the deposited sediment volume could be quantified. Therefore, after the identification of the average annual eroded material for the sub-basins, SEDD model was applied in order to reveal the annual transported sediment amount within each sub-basin of the study area. The results obtained from the SEDD model were compared with the bathymetry measurements of the reservoir. In this context, the first objective of this study is to propose a new approach to estimate the C factor by using remote sensing and GIS techniques with previous studies based on experimental studies conducted on field. The second objective of the study is to estimate RUSLE parameters by using available datasets and to examine the applicability of the method on other basins in Turkey with same datasets. The third objective of the study is to estimate the transported sediment

  18. Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor. alpha. : Relevance to genetic predisposition to systemic lupus erythematosus

    SciTech Connect

    Jacob, C.O.; Fronek, Z.; Koo, M.; McDevitt, H.O. ); Lewis, G.C. ); Hansen, J.A. )

    1990-02-01

    The authors report on the production of tumor necrosis factor (TNF)-{alpha} and TNF-{beta} by mitogen-activated peripheral blood lymphocytes or enriched monocyte subpopulations from human leukocyte antigen (HLA)-typed healthy subjects. The results indicate that HLA-DR2- and DQw1-positive donors frequently exhibit low production of TNF-{alpha}, whereas DR3- and DR4-positive subjects show high levels of TNF-{alpha} production. No correlation between TNF-{alpha} levels and HLA-A, -B, and -C genotype was found. The relevance of this quantitative polymorphism to the genetic predisposition to lupus nephritis in systemic lupus erythematosus (SLE) patients was investigated. DR2, DQw1-positive SLE patients show low levels of TNF-{alpha} inducibility; this genotype is also associated with an increased incidence of lupus nephritis. DR3-positive SLE patients, on the other hand, are not predisposed to nephritis, and these patients have high TNF-{alpha} production. DR4 haplotype is associated with high TNF-{alpha} inducibility and is negatively correlated with lupus nephritis. These data may help explain the strong association between HLA-DR2, DQw1 in SLE patients and their susceptibility to nephritis.

  19. Factors affecting the thermal environment of Agassiz’s Desert Tortoise (Gopherus agassizii) cover sites in the Central Mojave Desert during periods of temperature extremes

    USGS Publications Warehouse

    Mack, Jeremy S.; Berry, Kristin H.; Miller, David; Carlson, Andrea S.

    2015-01-01

    Agassiz's Desert Tortoises (Gopherus agassizii) spend >95% of their lives underground in cover sites that serve as thermal buffers from temperatures, which can fluctuate >40°C on a daily and seasonal basis. We monitored temperatures at 30 active tortoise cover sites within the Soda Mountains, San Bernardino County, California, from February 2004 to September 2006. Cover sites varied in type and structural characteristics, including opening height and width, soil cover depth over the opening, aspect, tunnel length, and surficial geology. We focused our analyses on periods of extreme temperature: in summer, between July 1 and September 1, and winter, between November 1 and February 15. With the use of multivariate regression tree analyses, we found cover-site temperatures were influenced largely by tunnel length and subsequently opening width and soil cover. Linear regression models further showed that increasing tunnel length increased temperature stability and dampened seasonal temperature extremes. Climate change models predict increased warming for southwestern North America. Cover sites that buffer temperature extremes and fluctuations will become increasingly important for survival of tortoises. In planning future translocation projects and conservation efforts, decision makers should consider habitats with terrain and underlying substrate that sustain cover sites with long tunnels and expanded openings for tortoises living under temperature extremes similar to those described here or as projected in the future.

  20. Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease.

    PubMed

    Ribeiro, Carlos A; Saraiva, Maria João; Cardoso, Isabel

    2012-01-01

    Transthyretin (TTR) protects against A-Beta toxicity by binding the peptide thus inhibiting its aggregation. Previous work showed different TTR mutations interact differently with A-Beta, with increasing affinities correlating with decreasing amyloidogenecity of the TTR mutant; this did not impact on the levels of inhibition of A-Beta aggregation, as assessed by transmission electron microscopy. Our work aimed at probing differences in binding to A-Beta by WT, T119M and L55P TTR using quantitative assays, and at identifying factors affecting this interaction. We addressed the impact of such factors in TTR ability to degrade A-Beta. Using a dot blot approach with the anti-oligomeric antibody A11, we showed that A-Beta formed oligomers transiently, indicating aggregation and fibril formation, whereas in the presence of WT and T119M TTR the oligomers persisted longer, indicative that these variants avoided further aggregation into fibrils. In contrast, L55PTTR was not able to inhibit oligomerization or to prevent evolution to aggregates and fibrils. Furthermore, apoptosis assessment showed WT and T119M TTR were able to protect against A-Beta toxicity. Because the amyloidogenic potential of TTR is inversely correlated with its stability, the use of drugs able to stabilize TTR tetrameric fold could result in increased TTR/A-Beta binding. Here we showed that iododiflunisal, 3-dinitrophenol, resveratrol, [2-(3,5-dichlorophenyl)amino] (DCPA) and [4-(3,5-difluorophenyl)] (DFPB) were able to increase TTR binding to A-Beta; however only DCPA and DFPB improved TTR proteolytic activity. Thyroxine, a TTR ligand, did not influence TTR/A-Beta interaction and A-Beta degradation by TTR, whereas RBP, another TTR ligand, not only obstructed the interaction but also inhibited TTR proteolytic activity. Our results showed differences between WT and T119M TTR, and L55PTTR mutant regarding their interaction with A-Beta and prompt the stability of TTR as a key factor in this interaction

  1. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials

    PubMed Central

    Early Breast Cancer Trialists' Collaborative Group (EBCTCG)

    2011-01-01

    Summary Background As trials of 5 years of tamoxifen in early breast cancer mature, the relevance of hormone receptor measurements (and other patient characteristics) to long-term outcome can be assessed increasingly reliably. We report updated meta-analyses of the trials of 5 years of adjuvant tamoxifen. Methods We undertook a collaborative meta-analysis of individual patient data from 20 trials (n=21 457) in early breast cancer of about 5 years of tamoxifen versus no adjuvant tamoxifen, with about 80% compliance. Recurrence and death rate ratios (RRs) were from log-rank analyses by allocated treatment. Findings In oestrogen receptor (ER)-positive disease (n=10 645), allocation to about 5 years of tamoxifen substantially reduced recurrence rates throughout the first 10 years (RR 0·53 [SE 0·03] during years 0–4 and RR 0·68 [0·06] during years 5–9 [both 2p<0·00001]; but RR 0·97 [0·10] during years 10–14, suggesting no further gain or loss after year 10). Even in marginally ER-positive disease (10–19 fmol/mg cytosol protein) the recurrence reduction was substantial (RR 0·67 [0·08]). In ER-positive disease, the RR was approximately independent of progesterone receptor status (or level), age, nodal status, or use of chemotherapy. Breast cancer mortality was reduced by about a third throughout the first 15 years (RR 0·71 [0·05] during years 0–4, 0·66 [0·05] during years 5–9, and 0·68 [0·08] during years 10–14; p<0·0001 for extra mortality reduction during each separate time period). Overall non-breast-cancer mortality was little affected, despite small absolute increases in thromboembolic and uterine cancer mortality (both only in women older than 55 years), so all-cause mortality was substantially reduced. In ER-negative disease, tamoxifen had little or no effect on breast cancer recurrence or mortality. Interpretation 5 years of adjuvant tamoxifen safely reduces 15-year risks of breast cancer recurrence and death. ER status was the

  2. A Follow-Up Investigation of the Role of Cover Story on the Assessment of Experimental Design Skills. CSE Technical Report.

    ERIC Educational Resources Information Center

    Zimmerman, Corinne; Glaser, Robert

    Cover story, in the sense of context, is a potentially relevant factor in the assessment of reasoning and problem solving in science, given repeated demonstration of its effects on laboratory tasks. This study follows up on a preliminary interview study that showed cover story influenced the way students were assessed at the end of an…

  3. Key Factors in the Rise of Mass Popular Education and Their Relevance for Education in Southern Africa in the Twenty-First Century.

    ERIC Educational Resources Information Center

    van Niekerk, E. J.

    This paper identifies the historical factors that played a key role in the rise of mass popular education and describes how these factors relate to education in Southern Africa in the 21st century. The broad overview of developments since the Renaissance begins with the Protestant Reformation, which established a theoretical basis for elementary…

  4. Linking spatio-temporal patterns in land cover dynamics with regional climate factors and recent weather: Application to the Flint Hills of Kansas and Oklahoma

    SciTech Connect

    Henebry, G.M.; Goodin, D.G.; Su, H.

    1995-06-01

    A key obstacle to developing regional models of ecosystem dynamics is representation of spatio-temporal variation in constituent patterns and processes. Simple resealing of site-specific ecological data or simulations to broader spatial scales is unlikely to capture regional spatio-temporal dynamics. Yet logistical constraints usually require synoptic weather data to be synthesized from sparse data networks. We seek a simple top-down model that links remotely-sensed vegetation cover with antecedent meteorological forcings to generate boundary conditions for site-specific fine-resolution data and simulations of tallgrass prairie. We developed several candidate models using AVHRR NDVI maximum biweekly composites of the Flint Hills from 1990-1993 and data from a network of more than 60 weather stations across the 40,000 km2 region. Models combined parameters derived from exemplary land cover trajectories, spatial structure (lacunarity and correlation length), and running weighted sums of weather data. Spectral-temporal models were easier to fit; lacunarity was more sensitive than correlation length; compositing effects were strong.

  5. Estimating Cloud Cover

    ERIC Educational Resources Information Center

    Moseley, Christine

    2007-01-01

    The purpose of this activity was to help students understand the percentage of cloud cover and make more accurate cloud cover observations. Students estimated the percentage of cloud cover represented by simulated clouds and assigned a cloud cover classification to those simulations. (Contains 2 notes and 3 tables.)

  6. Earthdata Search: The Relevance of Relevance

    NASA Technical Reports Server (NTRS)

    Quinn, Patrick

    2016-01-01

    Through recent usability studies, the issue of relevance became increasingly clear in the Earthdata Search Client. After all, if a user can't find the data they are looking for, nothing else we do matters. This presentation walks through usability testing findings and recent relevance improvements made to the Earthdata Search Client.

  7. Multiple layer insulation cover

    DOEpatents

    Farrell, James J.; Donohoe, Anthony J.

    1981-11-03

    A multiple layer insulation cover for preventing heat loss in, for example, a greenhouse, is disclosed. The cover is comprised of spaced layers of thin foil covered fabric separated from each other by air spaces. The spacing is accomplished by the inflation of spaced air bladders which are integrally formed in the cover and to which the layers of the cover are secured. The bladders are inflated after the cover has been deployed in its intended use to separate the layers of the foil material. The sizes of the material layers are selected to compensate for sagging across the width of the cover so that the desired spacing is uniformly maintained when the cover has been deployed. The bladders are deflated as the cover is stored thereby expediting the storage process and reducing the amount of storage space required.

  8. Relevance of Five-Factor Model personality traits for obsessive-compulsive symptoms in patients with psychotic disorders and their un-affected siblings.

    PubMed

    Schirmbeck, Frederike; Boyette, Lindy-Lou; van der Valk, Renate; Meijer, Carin; Dingemans, Peter; Van, Rien; de Haan, Lieuwe; Kahn, René S; de Haan, Lieuwe; van Os, Jim; Wiersma, Durk; Bruggeman, Richard; Cahn, Wiepke; Meijer, Carin; Myin-Germeys, Inez

    2015-02-28

    High rates of obsessive-compulsive symptoms (OCS) in schizophrenia require pathogenic explanations. Personality traits may represent risk and resiliency factors for the development of mental disorders and their comorbidities. The aim of the present study was to explore the associations between Five-Factor Model (FFM) personality traits and the liability for OCS in patients with psychotic disorders and in their un-affected siblings. FFM traits, occurrence and severity of OCS and (subclinical) psychotic symptoms were assessed in 208 patients and in 281 siblings. Differences in FFM traits between participants with vs. without comorbid OCS were examined and the predictive value of FFM traits on group categorization was evaluated. Associations between FFM traits and OCS severity were investigated. Patients and siblings with OCS showed significantly higher Neuroticism compared to their counterparts without OCS. Neuroticism was positively associated with higher OCS severity and significantly predicted group assignment in both patients and in siblings. Patients with comorbid OCS presented with lower scores on Extraversion and Conscientiousness. Higher Neuroticism, and to a lesser degree lower Extraversion and Conscientiousness might add to the vulnerability of patients with a psychotic disorder to also develop OCS. Future prospective studies are needed to elucidate proposed personality-psychopathology interrelations and possible mediating factors. PMID:25613659

  9. The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment.

    PubMed

    Sullivan, Aideen M; O'Keeffe, Gerard W

    2005-09-01

    Growth/differentiation factor-5 (GDF5) is a member of the transforming growth factor-beta superfamily which has potent effects on dopaminergic neurones in vitro and in vivo. GDF5 is under investigation as a potential therapeutic agent for Parkinson's disease (PD), which is caused by the progressive degeneration of dopaminergic neurones projecting from the substantia nigra (SN) to the striatum. In the rat ventral mesencephalon (VM; the developing SN), GDF5 expression peaks at embryonic day 14, the time at which dopaminergic neurones undergo terminal differentiation. Addition of GDF5 protein to cultures of embryonic rat VM increases the survival and improves the morphology of dopaminergic neurones in these cultures. GDF5 treatment also increases the number of cells which adopt a dopaminergic phenotype in cultures of VM progenitor cells. Intracerebral administration of GDF5 has potent neuroprotective and restorative effects on the nigrostriatal pathway in animal models of PD. Furthermore, addition of GDF5 protein to embryonic rat dopaminergic neuronal transplants improves their survival and function in a rat model of PD. Thus, GDF5 has potential applications to PD therapy as a dopaminergic neuroprotective agent and as a factor that may induce a dopaminergic neuronal fate in unrestricted progenitor cells. PMID:16185246

  10. Immunohistochemical assay for epidermal growth factor receptor on paraffin-embedded sections: validation against ligand-binding assay and clinical relevance in breast cancer.

    PubMed Central

    Newby, J. C.; A'Hern, R. P.; Leek, R. D.; Smith, I. E.; Harris, A. L.; Dowsett, M.

    1995-01-01

    Epidermal growth factor receptor (EGFR) has been the subject of much research since it was first described as a prognostic factor in breast cancer. The assay methods used and results obtained vary widely between studies. In this study 88 primary breast cancers were assayed for EGFR using a novel immunohistochemical assay performed on paraffin-embedded sections. The monoclonal antibody used was raised against purified, denatured EGFR, reacts with an epitope on the external domain and does not interfere with ligand binding. Twenty-two per cent of the tumours were EGFR positive using this assay. The results obtained were significantly correlated with those obtained by ligand-binding assay (r = 0.621, P = 0.011). The concordance rate was 82% (P < 0.001). The majority of discordant results could be explained by the presence of benign breast tissue and other non-malignant elements which could be seen to express EGFR on the immunohistochemical assay and were excluded from the score for this, but would be incorporated into ligand-binding assay results. The well-established inverse relationship between EGFR (as measured by this assay) and oestrogen receptor (ER) was seen (chi 2 = 24.9, P < 0.0001). In addition, in this exploratory study on a limited tumour set, EGFR was a significant adverse prognostic factor (on univariate but not multivariate analysis) for both relapse-free survival (P = 0.02) and overall survival (P = 0.03) when measured by this immunohistochemical assay, but was not significant when measured by ligand-binding assay. Images Figure 1 Figure 2 PMID:7779717

  11. Systems genetics of the nuclear factor-κB signal transduction network. I. Detection of several quantitative trait loci potentially relevant to aging.

    PubMed

    Diego, Vincent P; Curran, Joanne E; Charlesworth, Jac; Peralta, Juan M; Voruganti, V Saroja; Cole, Shelley A; Dyer, Thomas D; Johnson, Matthew P; Moses, Eric K; Göring, Harald H H; Williams, Jeff T; Comuzzie, Anthony G; Almasy, Laura; Blangero, John; Williams-Blangero, Sarah

    2012-01-01

    A theory of aging holds that senescence is caused by a dysregulated nuclear factor kappa B (NF-κB) signal transduction network (STN). We adopted a systems genetics approach in our study of the NF-κB STN. Ingenuity Pathways Analysis (IPA) was used to identify gene/gene product interactions between NF-κB and the genes in our transcriptional profiling array. Principal components factor analysis (PCFA) was performed on a sub-network of 19 genes, including two initiators of the toll-like receptor (TLR) pathway, myeloid differentiation primary response gene (88) (MyD88) and TIR (Toll/interleukin-1 receptor)-domain-containing adapter-inducing interferon-β (TRIF). TLR pathways are either MyD88-dependent or TRIF-dependent. Therefore, we also performed PCFA on a subset excluding the MyD88 transcript, and on another subset excluding two TRIF transcripts. Using linkage analysis we found that each set gave rise to at least one factor with a logarithm of the odds (LOD) score greater than 3, two on chromosome 15 at 15q12 and 15q22.2, and another two on chromosome 17 at 17p13.3 and 17q25.3. We also found several suggestive signals (2

  12. Study of Disease Progression and Relevant Risk Factors in Diabetic Foot Patients Using a Multistate Continuous-Time Markov Chain Model

    PubMed Central

    Begun, Alexander; Morbach, Stephan; Rümenapf, Gerhard; Icks, Andrea

    2016-01-01

    The diabetic foot is a lifelong disease. The longer patients with diabetes and foot ulcers are observed, the higher the likelihood that they will develop comorbidities that adversely influence ulcer recurrence, amputation and survival (for example peripheral arterial disease, renal failure or ischaemic heart disease). The purpose of our study was to quantify person and limb-related disease progression and the time-dependent influence of any associated factors (present at baseline or appearing during observation) based on which effective prevention and/or treatment strategies could be developed. Using a nine-state continuous-time Markov chain model with time-dependent risk factors, all living patients were divided into eight groups based on their ulceration (previous or current) and previous amputation (none, minor or major) status. State nine is an absorbing state (death). If all transitions are fully observable, this model can be decomposed into eight submodels, which can be analyzed using the methods of survival analysis for competing risks. The dependencies of the risk factors (covariates) were included in the submodels using Cox-like regression. The transition intensities and relative risks for covariates were calculated from long-term data of patients with diabetic foot ulcers collected in a single specialized center in North-Rhine Westphalia (Germany). The detected estimates were in line with previously published, but scarce, data. Together with the interesting new results obtained, this indicates that the proposed model may be useful for studying disease progression in larger samples of patients with diabetic foot ulcers. PMID:26814723

  13. Investigation into the phenomena affecting the retention behavior of basic analytes in chaotropic chromatography: Joint effects of the most relevant chromatographic factors and analytes' molecular properties.

    PubMed

    Čolović, Jelena; Kalinić, Marko; Vemić, Ana; Erić, Slavica; Malenović, Anđelija

    2015-12-18

    The aim of this study was to systematically investigate the phenomena affecting the retention behavior of structurally diverse basic drugs in ion-interaction chromatographic systems with chaotropic additives. To this end, the influence of three factors was studied: pH value of the aqueous phase, concentration of sodium hexafluorophosphate, and content of acetonitrile in the mobile phase. Mobile phase pH was found to affect the thermodynamic equilibria in the studied system beyond its effects on the analytes' ionization state. Specifically, increasing pH from 2 to 4 led to longer retention times, even with analytes which remain completely protonated. An explanation for this phenomenon was sought by studying the adsorption behavior of acetonitrile and chaotropic additive onto stationary phase. It was shown that the magnitude of the developed surface potential, which significantly affects retention - increases with pH, and that this can be attributed to the larger surface excess of acetonitrile. To study how analytes' structural properties influence their retention, quantitative structure-retention modeling was performed next. A support vector machine regression model was developed, relating mobile phase constituents and structural descriptors with retention data. While the ETA_EtaP_B_RC and XlogP can be considered as molecular descriptors which describe factors affecting retention in any RP-HPLC system, TDB9p and RDF45p are molecular descriptors which account for spatial arrangement of polarizable atoms and they can clearly relate to analytes' behavior on the stationary phase surface, where the electrostatic potential develops. Complementarity of analytes' structure with that of the electric double layer can be seen as a key factor influencing their retention behavior. Structural diversity of analytes and good predictive capabilities over a range of experimental conditions make the established model a useful tool in predicting retention behavior in the studied

  14. Factors associated with the use of home-visit nursing services covered by the long-term care insurance in rural Japan: a cross-sectional study

    PubMed Central

    2013-01-01

    Background In Japan, there is a large increase in the number of elderly persons who potentially need home-visit nursing services (VNS). However, the number of persons using the VNS has increased only little in comparison to the number of individuals who use home social services, which are also covered by the Long-Term Care Insurance (LTCI) system. This cross-sectional study investigated the predictors of the VNS used under the LTCI system in Japan. Methods We used 1,580 claim data from all the users of community-based services and 1,574 interview survey data collected in 2001 from the six municipal bodies in Japan. After we merged the two datasets, 1,276 users of community-based services under the LTCI were analyzed. Multiple logistic regression models stratified by care needs levels were used for analysis. Results Only 8.3% of the study subjects were VNS users. Even among study participants within the higher care-needs level, only 22.0% were VNS users. In the lower care level group, people with a higher care level (OR: 3.50, 95% CI: 1.50–8.93), those whose condition needed long term care due to respiratory or heart disease (OR: 4.31, 95% CI: 1.88–89.20), those whose period of needing care was two years or more (OR: 2.01, 95% CI: 1.14–3.48), those whose service plan was created by a medical care management agency (OR: 2.39, 95% CI: 1.31–4.33), those living with family (OR: 1.86, 95% CI: 1.00–3.42), and those who use home-help services (OR: 2.12, 95% CI: 1.17–3.83) were more likely to use the VNS. In the higher care level group, individuals with higher care level (OR: 3.63, 95% CI: 1.56–8.66), those with higher income (OR: 3.79, 95% CI: 1.01–14.25), and those who had regular hospital visits before entering the LTCI (OR: 2.36, 95% CI: 1.11–5.38) were more likely to use the VNS. Conclusions Our results suggested that VNS use is limited due to management by non-medical care management agencies, due to no caregivers being around or a low income

  15. Cover Your Cough

    MedlinePlus

    ... What's this? Submit Button Past Newsletters Cover Your Cough Language: English Español Recommend on Facebook Tweet ... Posters only available as PDF files. Cover Your Cough, Flyer for Health Care Settings English [324 KB] ...

  16. Dietary Intake, Food Processing, and Cooking Methods Among Amish and Non-Amish Adults Living in Ohio Appalachia: Relevance to Nutritional Risk Factors for Cancer

    PubMed Central

    Cuyun Carter, Gebra B.; Katz, Mira L.; Ferketich, Amy K.; Clinton, Steven K.; Grainger, Elizabeth M.; Paskett, Electra D.; Bloomfield, Clara D.

    2013-01-01

    This study’s purpose was to examine the source, storage, preparation, and intake of food among Amish and non-Amish adults to understand dietary practices as a potential contributing factor to lower cancer incidence rates. Interviews were conducted with a random sample of 134 Amish and 154 non-Amish adults including questions about dietary practices and a 24-h dietary recall. Amish compared to non-Amish adults reported (1) less refrigeration in homes (85% vs. 100%, P < .01); (2) rarely/never obtaining food from restaurants and grocery stores (P < .01); (3) consuming less alcohol (P < .01); (4) consuming fewer daily servings of vegetables (males: 1.2 vs. 1.9 servings/day, P < .01; females: 1.0 vs. 2.1 servings/day, P < .01); and (5) a greater percentage of energy from saturated fat (males: 16.7% vs. 12.6%, P < .01; females: 16.3% vs. 12.0%, P < .01). Amish males reported greater amount of energy intake (2780 kcal vs. 2298 kcal, P = .03) compared to non-Amish males. Amish and non-Amish dietary patterns show some differences that may impact cancer although neither group achieves current diet and cancer prevention guidelines. Lifestyle factors, screening, and healthcare access may be contributing to the lower cancer incidence rates among the Amish and these results suggest areas of intervention to reduce the cancer burden. PMID:22026912

  17. The Relevance of Beta-Amyloid on Markers of Alzheimer’s Disease in Clinically Normal Individuals and Factors That Influence These Associations

    PubMed Central

    Mormino, Elizabeth C.

    2015-01-01

    Aberrant accumulation of beta-amyloid (Aβ) is thought to be an early event in a biological cascade that eventually leads to Alzheimer’s disease (AD). Along these lines, many clinically normal (CN) older individuals have evidence of beta-amyloid (Aβ) accumulation, which may be indicative of preclinical AD. However, relationships between Aβ and “downstream” AD markers are often inconsistent across studies. These inconsistencies may be due to the presence of other age-related processes that also influence AD markers, as well as additional risk factors that interact with Aβ to influence downstream changes. For instance, it is possible that the effect of Aβ is modified by neurodegeneration, genetics, sex-differences and cognitive reserve. Thus, a multivariate approach to determining risk of AD within CN participants may be more appropriate than reliance on Aβ status alone. An understanding of how additional risk factors interact with Aβ to influence an individual’s trajectory towards AD is essential for characterizing preclinical AD and has implications for prevention trials. PMID:25108368

  18. Clinical Relevance of Transforming Growth Factor-β1, Interleukin-6 and Haptoglobin for Prediction of Obesity Complications in Prepubertal Egyptian Children

    PubMed Central

    El-Alameey, Inas R.; Fadl, Nevein N.; Hameed, Enas R. Abdel; Sherif, Lobna S.; Ahmed, Hanaa H.

    2015-01-01

    BACKGROUND: The rate of obesity is increasing throughout the world. Obesity in adults’ research is characterized by chronic inflammation, associated with type 2 Diabetes and cardiovascular risk. The degree to which these changes occur in childhood obesity is not fully defined. AIM: This study was designed to explore the relation between circulating levels of pro-inflammatory cytokines, and obesity. PATIENTS AND METHODS: This cross sectional case control study was carried out in 50 randomly selected pre-pubertal overweight and obese children compared with fifty apparently healthy children of matched age and sex. Serum levels of transforming growth factor-β1, interleukin-6, and haptoglobin were quantified by ELISA technique. RESULTS: ANOVA test followed by Post Hoc test showed highly significant increase in the serum levels of the transforming growth factor-β1, interleukin-6 and haptoglobin among obese children compared to overweight and healthy children respectively. The body weight, BMI and BMI z-score were significantly positively correlated with serum levels of the three pro-inflammatory cytokines. Serum levels of interleukin-6, and haptoglobin were found to be strong predictors of complications in severe obesity by linear regression analysis. CONCLUSIONS: Obesity is associated with chronic low-grade inflammation. High levels of interleukin-6 and haptoglobin are considered to be early biomarkers of inflammation associated with severe obesity with subsequent cardiovascular and type 2 diabetes risk.

  19. Function of all-trans retinoic acid observation on similar myopia changes in cultivated rabbit retinal pigment epithelium and relation with myopia relevant factors.

    PubMed

    Xing, Bin

    2016-03-01

    To observe the role of all-trans retinoic acid (ATRA) during the similar myopia changes of cultured rabbit retinal pigment epithelium (RPE) cells, as well as the variation changes and relationships with myopic correlation factors such as hepatocyte growth factor (HGF) and matrix metalloprateinase-2 (MMP-2). Rabbit RPE cells of primary generation were selected and cultured to fifth generation by subculture. Then the morphology of RPE cells were observed and cell vitality was analyzed by using the Trypan blue reject test. The expressions of HGF and MMP-2 in RPE cells were tested by using an immunobistochemistry method. The HGF concentration in RPE cell culture fluid was detected by applying enzyme-linked immunosorbnent assay (ELISA). As the ATRA concentration enhanced and action time prolonged, the survival rate of RPE cells was reduced, but the expressions of HGF and MMP-2 increased, so did the secretion of HGF. ATRA concentration with no less than 5 nM/ml was able to induce the growth inhibition of RPE cells and the decrease in survival rate, which was similar to the changes in RPE cells in myopia. With the actin of ATRA, the expressions of HGF and MMP-2 increased in RPE cells, with more distinct in HGF increase. PMID:27113312

  20. How relevant is the deposition of mercury onto snowpacks? - Part 1: A statistical study on~the~impact of environmental factors

    NASA Astrophysics Data System (ADS)

    Durnford, D. A.; Dastoor, A. P.; Steen, A. O.; Berg, T.; Ryzhkov, A.; Figueras-Nieto, D.; Hole, L. R.; Pfaffhuber, K. A.; Hung, H.

    2012-10-01

    deposited through wet processes is more strongly retained by snowpacks than mercury deposited through dry processes. Revolatilization of mercury deposited through wet processes may be inhibited through burial by fresh snowfalls and/or by its more central location, compared to that of mercury deposited through dry deposition, within snowpack snow grains. The two depositions of oxidized mercury together explain 84% of the variability in observed concentrations of mercury in surface snow, 52% of the variability of observed concentrations of mercury in seasonal snowpacks and their meltwater's ionic pulse, and only 20% of the variability of observed concentrations of mercury in long-term snowpack-related records; other environmental controls seemingly gain in relevance as time passes. The concentration of mercury in long-term records is apparently primarily affected by latitude; both the primary sources of anthropogenic mercury and the strong upper-level zonal winds are located in the midlatitudes.

  1. Cover crops for Alabama

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cover crops are grown to benefit the following crop as well as to improve the soil, but they are normally not intended for harvest. Selecting the right cover crops for farming operations can improve yields, soil and water conservation and quality, and economic productivity. Properly managed cover ...

  2. Cover Crop Management

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The potential benefits of cover crops in vegetable production systems depend on the type of cover crop that is used and how it is managed from planting to termination date. This chapter focuses on management practices that are applicable to a broad range cover crops and vegetable production systems ...

  3. Age-Group-Specific Associations between the Severity of Obstructive Sleep Apnea and Relevant Risk Factors in Male and Female Patients

    PubMed Central

    Deng, Xingqi; Gu, Wei; Li, Yanyan; Liu, Mei; Li, Yan; Gao, Xiwen

    2014-01-01

    Aim To seek accurate and credible correlation manner between gender, age, and obesity; and the severity of obstructive sleep apnea (OSA) in large-scale population. Methods Totals of 1,975 male and 378 female OSA patients were sequentially recruited. Centralized covariant tendencies between age, body mass index (BMI), and waist hip ratio (WHR); and OSA severity, were explored in a gender-specific manner via multiple statistical analyses. The accuracies of observed correlations were further evaluated by adaptive multiple linear regression. Results All of age, BMI, WHR, smoking, drinking, and OSA severity differed between males and females. BMI and WHR were positively and (approximately) linearly associated with OSA severity in both males and females. Restricted cubic spline analysis was more effective than was the Pearson correlation approach in correlating age with AHI, and provided age crossover points allowing further piecewise linear modeling for both males and females. Multiple linear regression showed that increasing age was associated with OSA exacerbation in males aged ≤40 years and in females aged 45–53 years. BMI, WHR, and diabetes were independently associated with OSA severity in males with age-group-specific pattern. In females, only BMI was associated with OSA severity at all ages. Conclusions In male patients, BMI and WHR are prominent risk factors for OSA exacerbation. Age and diabetes are associated with OSA severity in males of particular ages. In females, BMI is also a prominent risk factor for severe OSA, and OSA severity increased with age in the range 45–53 years. PMID:25211035

  4. Prime Time Sister Circles: evaluating a gender-specific, culturally relevant health intervention to decrease major risk factors in mid-life African-American women.

    PubMed Central

    Gaston, Marilyn Hughes; Porter, Gayle K.; Thomas, Veronica G.

    2007-01-01

    PURPOSE: To evaluate the effectiveness of Prime Time Sister Circles (PTSC), a curriculum-based, culture- and gender-specific health intervention, in assisting mid-life African-American women to decrease the major risk factors of physical inactivity, poor nutrition and stress. METHODS: One-hundred-thirty-four African-American women were involved in 11 sites across the country in PTSC and comparison groups. PTSC uses a cognitive behavioral modality based on three theoretical approaches to reduce risk factors and promote positive health changes. Pretest and posttest (10 weeks, and six and 12 months) data were collected on various indicators. RESULTS: t test analyses demonstrated a statistically significant increase in the women's involvement in physical activity at 10 weeks, and six and 12 months. A significant 10-week difference was found in the women's diet, with them reporting eating more nutritious foods, t(77) = 3.32, p < 0.001. The women also indicated from pretest to 10 weeks, and six and 12 months that they changed what they ate to prevent disease (40.4%, 62.8%, 97.5% and 100%, respectively). A majority of the women at 10 weeks (62.7%) and 12 months (65.9%) reported utilizing stress management strategies. There was also a 60% increase in yearly mammograms and a 54% increase in blood pressures checks. Finally, 83.7% of the women at 12 months felt that the positive changes could be maintained over their lifetime. CONCLUSIONS: This study demonstrates the effectiveness of PTSC in modifying health-related knowledge, attitudes and certain high-risk behaviors in mid-life African-American women. PMID:17444433

  5. Cover times of random searches

    NASA Astrophysics Data System (ADS)

    Chupeau, Marie; Bénichou, Olivier; Voituriez, Raphaël

    2015-10-01

    How long must one undertake a random search to visit all sites of a given domain? This time, known as the cover time, is a key observable to quantify the efficiency of exhaustive searches, which require a complete exploration of an area and not only the discovery of a single target. Examples range from immune-system cells chasing pathogens to animals harvesting resources, from robotic exploration for cleaning or demining to the task of improving search algorithms. Despite its broad relevance, the cover time has remained elusive and so far explicit results have been scarce and mostly limited to regular random walks. Here we determine the full distribution of the cover time for a broad range of random search processes, including Lévy strategies, intermittent strategies, persistent random walks and random walks on complex networks, and reveal its universal features. We show that for all these examples the mean cover time can be minimized, and that the corresponding optimal strategies also minimize the mean search time for a single target, unambiguously pointing towards their robustness.

  6. Tamper resistant choke cover

    SciTech Connect

    Kneipkamp, L.E.

    1981-12-29

    A carburetor improvement is described for inhibiting tampering with a thermostatic choke coil after carburetor manufacture. A cover (3) fits over a choke coil housing (H) to enclose a choke lever, the thermostatic coil being mounted inside the cover. The cover has a circumferential flange (5) which abuts the outer surface of the housing, the flange having a notch (9) formed therein and the cover being rotatable about the outer surface of the housing to position one end of the coil relative to the choke lever. A retainer (7) locks the cover in a fixed position once the one end of the coil is located with respect to the choke lever. The retainer has a tab (11) insertable in the notch to prevent further rotation of the cover. A screw (15) having a detachable head (17) unremovably secures the retainer to the carburetor whereby once the retainer is secured, further movement of the cover is prevented.

  7. Incidence and predictive factors of first episode of spontaneous bacterial peritonitis in cirrhosis with ascites: relevance of ascitic fluid protein concentration.

    PubMed

    Llach, J; Rimola, A; Navasa, M; Ginès, P; Salmerón, J M; Ginès, A; Arroyo, V; Rodés, J

    1992-09-01

    To investigate the long-term probability of the appearance of the first episode of spontaneous bacterial peritonitis in cirrhosis with ascites and to identify predictors of this complication, we closely followed throughout their illness 127 patients consecutively admitted to our unit for the treatment of an episode of ascites without prior spontaneous bacterial peritonitis (follow-up period: 21 +/- 22 mo). Thirteen patients (10%) had the first spontaneous bacterial peritonitis episode during follow-up. The appearance probability of this complication is 11% at 1 yr and 15% at 3 yr. Thirty-three variables obtained at admission (including clinical data, standard liver and kidney function test results, ascitic fluid protein concentrations and hemodynamic parameters) were analyzed in relation to their value in predicting spontaneous bacterial peritonitis development. In univariate analysis (Kaplan-Meier curves) five variables reached statistical significance (p less than 0.05) as predictive factors for the development of the first spontaneous bacterial peritonitis episode. These five variables were poor nutritional status, increased serum bilirubin levels, increased serum AST levels, decreased prothrombin activity and reduced total protein concentration in ascitic fluid. When these five variables were introduced in a multivariate analysis, only the ascitic fluid protein concentration was found to correlate independently with spontaneous bacterial peritonitis development (p = 0.002). The probability of first spontaneous bacterial peritonitis after 3 yr of follow-up was 24% and 4% in patients with ascitic fluid protein content lower than 1 gm/dl and greater than or equal to 1 gm/dl, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1505916

  8. si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder

    PubMed Central

    2011-01-01

    Background In experimental models of fetal alcohol spectrum disorder (FASD), cerebellar hypoplasia and hypofoliation are associated with insulin and insulin-like growth factor (IGF) resistance with impaired signaling through pathways that mediate growth, survival, plasticity, metabolism, and neurotransmitter function. To more directly assess the roles of impaired insulin and IGF signaling during brain development, we administered intracerebroventricular (ICV) injections of si-RNA targeting the insulin receptor, (InR), IGF-1 receptor (IGF-1R), or IGF-2R into postnatal day 2 (P2) Long Evans rat pups and examined the sustained effects on cerebellar function, structure, and neurotransmitter-related gene expression (P20). Results Rotarod tests on P20 demonstrated significant impairments in motor function, and histological studies revealed pronounced cerebellar hypotrophy, hypoplasia, and hypofoliation in si-InR, si-IGF-1R, and si-IGF-2R treated rats. Quantitative RT-PCR analysis showed that si-InR, and to a lesser extent si-IGF-2R, broadly inhibited expression of insulin and IGF-2 polypeptides, and insulin, IGF-1, and IGF-2 receptors in the brain. ELISA studies showed that si-InR increased cerebellar levels of tau, phospho-tau and β-actin, and inhibited GAPDH. In addition, si-InR, si-IGF-1R, and si-IGF-2R inhibited expression of choline acetyltransferase, which mediates motor function. Although the ICV si-RNA treatments generally spared the neurotrophin and neurotrophin receptor expression, si-InR and si-IGF-1R inhibited NT3, while si-IGF-1R suppressed BDNF. Conclusions early postnatal inhibition of brain InR expression, and to lesser extents, IGF-R, causes structural and functional abnormalities that resemble effects of FASD. The findings suggest that major abnormalities in brains with FASD are mediated by impairments in insulin/IGF signaling. Potential therapeutic strategies to reduce the long-term impact of prenatal alcohol exposure may include treatment with agents

  9. Armored Geomembrane Cover Engineering

    PubMed Central

    Foye, Kevin

    2011-01-01

    Geomembranes are an important component of modern engineered barriers to prevent the infiltration of stormwater and runoff into contaminated soil and rock as well as waste containment facilities—a function generally described as a geomembrane cover. This paper presents a case history involving a novel implementation of a geomembrane cover system. Due to this novelty, the design engineers needed to assemble from disparate sources the design criteria for the engineering of the cover. This paper discusses the design methodologies assembled by the engineering team. This information will aid engineers designing similar cover systems as well as environmental and public health professionals selecting site improvements that involve infiltration barriers. PMID:21776229

  10. The Many Organisational Factors Relevant to Planning Change in Emergency Care Departments: A Qualitative Study to Inform a Cluster Randomised Controlled Trial Aiming to Improve the Management of Patients with Mild Traumatic Brain Injuries

    PubMed Central

    Bosch, Marije; Tavender, Emma J.; Brennan, Sue E.; Knott, Jonathan; Gruen, Russell L.; Green, Sally E.

    2016-01-01

    commitment, but relatively low change efficacy). Regarding implementation processes, the importance of (visible) senior leadership for all professions involved was identified as a critical factor. An unpredictable and hectic environment brings challenges in creating an environment in which team-based and organisational learning can thrive (system antecedents for innovation). In addition, the position of the ED as the entry-point of the hospital points to the relevance of securing buy-in from other units. Conclusions We identified several organisational factors relevant to realising change in ED management of patients who present with mild head injuries. These factors will inform the intervention design and process evaluation in a trial evaluating the effectiveness of our implementation intervention. PMID:26845772

  11. Perceptions of document relevance

    PubMed Central

    Bruza, Peter; Chang, Vivien

    2014-01-01

    This article presents a study of how humans perceive and judge the relevance of documents. Humans are adept at making reasonably robust and quick decisions about what information is relevant to them, despite the ever increasing complexity and volume of their surrounding information environment. The literature on document relevance has identified various dimensions of relevance (e.g., topicality, novelty, etc.), however little is understood about how these dimensions may interact. We performed a crowdsourced study of how human subjects judge two relevance dimensions in relation to document snippets retrieved from an internet search engine. The order of the judgment was controlled. For those judgments exhibiting an order effect, a q–test was performed to determine whether the order effects can be explained by a quantum decision model based on incompatible decision perspectives. Some evidence of incompatibility was found which suggests incompatible decision perspectives is appropriate for explaining interacting dimensions of relevance in such instances. PMID:25071622

  12. ENGINEERING BULLETIN: LANDFILL COVERS

    EPA Science Inventory

    Landfill covers are used at Superfund sites to minimize surface water infiltration and control gas migration. In many cases covers are used in conjunction with other waste treatment technologies, such as slurry walls, ground water pump-and-treat systems, and gas collection. This ...

  13. Silostop Bunker Covers

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The quality of the seal provided by the plastic cover is a key issue for minimizing losses in bunker and pile silos. Most bunker covers are 6 to 8 mil polyethylene sheets held in place by tires or tire sidewalls. Frequently there are problems with spoilage at the shoulders (i.e., against the walls),...

  14. On the Cover

    ERIC Educational Resources Information Center

    Hays, Kate F.

    2006-01-01

    This is a discussion with Judith Warren regarding her painting on the cover of the present issue of American Psychologist. To Warren, the painting on the cover of this issue, Pentimento, speaks to the interplay of spontaneity and intentionality in psychotherapy.

  15. The Importance of Being Relevant

    PubMed Central

    Jaswal, Snehlata

    2012-01-01

    This review aims at an understanding of the binding process by synthesizing the extant perspectives regarding binding. It begins with a consideration of the biological explanations of binding, viz., conjunctive coding, synchrony, and reentrant mechanisms. Thereafter binding is reviewed as a psychological process guided by top-down signals. The stages and types of binding proposed by various researchers are discussed in this section. The next section introduces Working Memory (WM) as the executive directing the top-down signals. After that it is described how WM works by selecting relevant sensory input, followed by a detailed consideration of the debate regarding objects vs. features with the conclusion that relevance is the key factor determining what is processed. The next section considers other factors affecting the selection of relevant input. Then, we shift focus to describe what happens to irrelevant input – whether it is discarded at the outset or is gradually inhibited, and whether inhibition is a perceptual or post-perceptual process. The concluding section describes the process of binding as currently understood on the basis of the literature included in the review. To summarize, it appears that initially the “object” is conceptualized as an instantaneous bundle of all features. However, only relevant features of stimuli are gradually integrated to form a stable representation of the object. Concomitantly, irrelevant features are removed from the object representations. Empirical evidence suggests that the inhibition of irrelevant features occurs over time and is presumably a process within WM. PMID:22969739

  16. Land Cover Trends Project

    USGS Publications Warehouse

    Acevedo, William

    2006-01-01

    The Land Cover Trends Project is designed to document the types, rates, causes, and consequences of land cover change from 1973 to 2000 within each of the 84 U.S. Environmental Protection Agency (EPA) Level III ecoregions that span the conterminous United States. The project's objectives are to: * Develop a comprehensive methodology using probability sampling and change analysis techniques and Landsat Multispectral Scanner (MSS), Thematic Mapper (TM), and Enhanced Thematic Mapper (ETM) data for estimating regional land cover change. * Characterize the spatial and temporal characteristics of conterminous U.S. land cover change for five periods from 1973 to 2000 (nominally 1973, 1980, 1986, 1992, and 2000). * Document the regional driving forces and consequences of change. * Prepare a national synthesis of land cover change.

  17. Spectrum factors relevant to phonetogram measurement.

    PubMed

    Gramming, P; Sundberg, J

    1988-06-01

    Phonetograms showing the sound-pressure level (SPL) in loudest and softest possible phonation are frequently used in some voice clinics as an aid for describing the status of voice function. Spectrum analysis of the vowel /a/ produced by ten females and ten males with healthy, untrained voices revealed that the fundamental was mostly the strongest spectrum partial in soft phonation while the loudest partial in loud phonation was generally an overtone. Also, the first-formant frequency was generally lower in soft than in loud phonation. Measuring SPL in dB(A) rather than in dB lowered the phonetogram contour for soft phonation, an effect increasing with decreasing fundamental frequency. SPL measurements on a group of 22 females with healthy voices showed that the vowel /a/ gave higher SPL values than other vowels in loud phonation. The effect of using dB rather the dB(A) was great but similar for all vowels in soft phonation while, in loud phonation, the effect was small, particularly for /a/. In dB, the effect of using different vowels amounts to about +/- 5 dB, approximately. Interpretation of a phonetogram in terms of voice physiology is facilitated if SPL is given in dB and if a vowel with a high first-formant frequency is used. PMID:3411026

  18. 28 CFR 51.57 - Relevant factors.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... afforded members of racial and language minority groups an opportunity to participate in the decision to make the change. (d) The extent to which the jurisdiction took the concerns of members of racial...

  19. Rigor, Relevance and Relationships

    ERIC Educational Resources Information Center

    McNulty, Raymond J.; Quaglia, Russell J.

    2007-01-01

    Rigor, relevance, and relationships are three elements that provide the hallmark for education today. These three elements are integrally connected; if one is missing in a teacher's teaching practices, he or she is not doing his or her best to prepare students for success in school and in life. To ensure the inclusion of both rigor and relevance,…

  20. Culturally Relevant Pedagogy

    ERIC Educational Resources Information Center

    Irvine, Jacqueline Jordan

    2010-01-01

    Many teachers have only a cursory understanding of culturally relevant pedagogy, and their efforts to bridge the cultural gap often fall short. Culturally relevant pedagogy is a term that describes effective teaching in culturally diverse classrooms. It can be a daunting idea to understand and implement. Yet people tend to appreciate culturally…

  1. Making Science Relevant

    ERIC Educational Resources Information Center

    Eick, Charles; Deutsch, Bill; Fuller, Jennifer; Scott, Fletcher

    2008-01-01

    Science teachers are always looking for ways to demonstrate the relevance of science to students. By connecting science learning to important societal issues, teachers can motivate students to both enjoy and engage in relevant science (Bennet, Lubben, and Hogarth 2007). To develop that connection, teachers can help students take an active role in…

  2. Evapotranspiration (ET) covers.

    PubMed

    Rock, Steve; Myers, Bill; Fiedler, Linda

    2012-01-01

    Evapotranspiration (ET) cover systems are increasingly being used at municipal solid waste (MSW) landfills, hazardous waste landfills, at industrial monofills, and at mine sites. Conventional cover systems use materials with low hydraulic permeability (barrier layers) to minimize the downward migration of water from the surface to the waste (percolation), ET cover systems use water balance components to minimize percolation. These cover systems rely on soil to capture and store precipitation until it is either transpired through vegetation or evaporated from the soil surface. Compared to conventional membrane or compacted clay cover systems, ET cover systems are expected to cost less to construct. They are often aesthetic because they employ naturalized vegetation, require less maintenance once the vegetative system is established, including eliminating mowing, and may require fewer repairs than a barrier system. All cover systems should consider the goals of the cover in terms of protectiveness, including the pathways of risk from contained material, the lifecycle of the containment system. The containment system needs to be protective of direct contact of people and animals with the waste, prevent surface and groundwater water pollution, and minimize release of airborne contaminants. While most containment strategies have been based on the dry tomb strategy of keeping waste dry, there are some sites where adding or allowing moisture to help decompose organic waste is the current plan. ET covers may work well in places where complete exclusion of precipitation is not needed. The U.S. EPA Alternative Cover Assessment Program (ACAP), USDOE, the Nuclear Regulatory Commission, and others have researched ET cover design and efficacy, including the history of their use, general considerations in their design, performance, monitoring, cost, current status, limitations on their use, and project specific examples. An on-line database has been developed with information

  3. Radiative Gaunt factors

    NASA Astrophysics Data System (ADS)

    Burgess, Alan; Summers, Hugh P.

    1987-05-01

    Numerical methods for the evaluation of radiative Gaunt factors for complex ions, and for the calculation of the principal integrals over the Gaunt factors relevant to plasma spectroscopy, are presented. The present techniques are suitable for the computation of intermediate accuracy results for large numbers of ions over extended parameter ranges, and they cover bound-bound, bound-free, and free-free cases in both hydrogenic and nonhydrogenic approximations. The results demonstrate the reliability of the numerical methods and their advantages over the methods of Peach (1965, 1967) and Burgess and Seaton (1960). Significant differences from hydrogenic results at low and moderate z values are pointed out.

  4. Land Cover Characterization Program

    USGS Publications Warehouse

    U.S. Geological Survey

    1997-01-01

    (2) identify sources, develop procedures, and organize partners to deliver data and information to meet user requirements. The LCCP builds on the heritage and success of previous USGS land use and land cover programs and projects. It will be compatible with current concepts of government operations, the changing needs of the land use and land cover data users, and the technological tools with which the data are applied.

  5. WATER COOLED RETORT COVER

    DOEpatents

    Ash, W.J.; Pozzi, J.F.

    1962-05-01

    A retort cover is designed for use in the production of magnesium metal by the condensation of vaporized metal on a collecting surface. The cover includes a condensing surface, insulating means adjacent to the condensing surface, ind a water-cooled means for the insulating means. The irrangement of insulation and the cooling means permits the magnesium to be condensed at a high temperature and in massive nonpyrophoric form. (AEC)

  6. Graphical methods for evaluating covering arrays

    SciTech Connect

    Kim, Youngil; Jang, Dae -Heung; Anderson-Cook, Christine M.

    2015-08-10

    Covering arrays relax the condition of orthogonal arrays by only requiring that all combination of levels be covered but not requiring that the appearance of all combination of levels be balanced. This allows for a much larger number of factors to be simultaneously considered but at the cost of poorer estimation of the factor effects. To better understand patterns between sets of columns and evaluate the degree of coverage to compare and select between alternative arrays, we suggest several new graphical methods that show some of the patterns of coverage for different designs. As a result, these graphical methods for evaluating covering arrays are illustrated with a few examples.

  7. Methods for Cloud Cover Estimation

    NASA Technical Reports Server (NTRS)

    Glackin, D. L.; Huning, J. R.; Smith, J. H.; Logan, T. L.

    1984-01-01

    Several methods for cloud cover estimation are described relevant to assessing the performance of a ground-based network of solar observatories. The methods rely on ground and satellite data sources and provide meteorological or climatological information. One means of acquiring long-term observations of solar oscillations is the establishment of a ground-based network of solar observatories. Criteria for station site selection are: gross cloudiness, accurate transparency information, and seeing. Alternative methods for computing this duty cycle are discussed. The cycle, or alternatively a time history of solar visibility from the network, can then be input to a model to determine the effect of duty cycle on derived solar seismology parameters. Cloudiness from space is studied to examine various means by which the duty cycle might be computed. Cloudiness, and to some extent transparency, can potentially be estimated from satellite data.

  8. Surface erosion at disturbed alpine sites: effects of vegetation cover and plant diversity

    NASA Astrophysics Data System (ADS)

    Martin, C.; Pohl, M.; Alewell, C.; Körner, C.; Buttler, A.; Rixen, C.

    2009-04-01

    The relationship between plant diversity and soil stability in disturbed alpine terrain is poorly studied. In this paper, we investigated the influence of plant cover and diversity on water run-off and sediment yield on ski slopes. Rainfall simulations were conducted on a micro-scale (25 x 25 cm) to be able to replicate plots with different degrees of vegetation cover. We selected plots with 10%, 30% and 60% of vegetation cover containing different combinations of plant diversities: (i) grass, (ii) herb, (iii) moss/ lichen, and all combinations of these plant groups. Each combination was replicated five times with an applied rain intensity of 375 ml min-1 for about 5 minutes. As could be expected, percent vegetation cover had a large effect on surface erosion: sediment yield decreased with increasing vegetation cover. However, within the plots with 60% cover, sediment yield was lower at higher plant diversity and functional group diversity. The findings of this study support the view that beside the re-establishment of a closed vegetation cover, plant diversity is a relevant factor to reduce surface erosion at disturbed sites in alpine ecosystems.

  9. Fine Scale Assessment of Forest Cover Change over South America using Landsat Data

    NASA Astrophysics Data System (ADS)

    Huang, C.; Sexton, J. O.; Narasimhan, R.; Song, K.; Masek, J. G.; Kim, D.; Song, D.; Channan, S.; Feng, M.; Tan, B.; Townshend, J. R.

    2011-12-01

    Land cover change is one of the most important drivers of changes in the Earth System. Of all land cover changes, deforestation is one of the most significant because of the magnitude of the resultant transformations in biophysical and ecological properties. Forest cover change is highly relevant to many studies of pressing environmental issues, including the global carbon cycle, changes in the hydrological cycle, an understanding of the causes of changes in biodiversity and in understanding the rates and causes of land use change. As such, a number of national and international programs call for routine monitoring of global forest changes. Accurate characterization of forest change requires Landsat-class resolution data sets, because many changes, especially those resulting from anthropogenic factors, occur at hectare or sub-hectare scales. This poster reports on an assessment of forest cover change using Landsat data over the South America continent, which is part of a larger, ongoing global forest cover change mapping activity. We have produced surface reflectance products using Global Land Survey (GLS) Landsat images acquired around1990, 2000, and 2005, and are currently using them to produce forest cover change products. These products will be validated comprehensively, and will be used to calculate land cover and forest change rates for different countries and critical ecosystems and biomes. First derived using a wall-to-wall mapping approach at Landsat resolutions, these estimates will be compared with estimates derived using other means, including those published by the Food and Agriculture Organization (FAO).

  10. Spaceship EAC - Fostering Activities Relevant to Lunar Exploration and ISRU

    NASA Astrophysics Data System (ADS)

    Cowley, A.; Haefner, T.; Beltzung, J. C.; Meurisse, A.

    2015-10-01

    This presentation would cover the Spaceship EAC initiative, which aims to foster activities within ESA that are relevant to future human spaceflight and lunar exploration. We present our work in the area of regolith processing to date.

  11. ADA--covered entities--shareholder-directors as employees. Clackamas Gastroenterology Associates v. Deborah Wells.

    PubMed

    2004-01-01

    Control is the touchstone for determining whether an individual is an employee for the purpose of determining if a business entity is a "covered entity" subject to Americans with Disabilities Act (ADA). Thus, if shareholder-directors operate independently and manage the business, they are proprietors and not employees, but if they are subject to the firm's control, they are employees. All the incidents of the relationship must be considered with no one factor being decisive. The Equal Employment Opportunity Commission's (EEOC's) six relevant factors provide the guidelines. PMID:15453202

  12. Automatic cloud cover mapping.

    NASA Technical Reports Server (NTRS)

    Strong, J. P., III; Rosenfeld, A.

    1971-01-01

    A method of converting a picture into a 'cartoon' or 'map' whose regions correspond to differently textured regions is described. Texture edges in the picture are detected, and solid regions surrounded by these (usually broken) edges are 'colored in' using a propagation process. The resulting map is cleaned by comparing the region colors with the textures of the corresponding regions in the picture, and also by merging some regions with others according to criteria based on topology and size. The method has been applied to the construction of cloud cover maps from cloud cover pictures obtained by satellites.

  13. Reusable pipe flange covers

    DOEpatents

    Holden, James Elliott; Perez, Julieta

    2001-01-01

    A molded, flexible pipe flange cover for temporarily covering a pipe flange and a pipe opening includes a substantially round center portion having a peripheral skirt portion depending from the center portion, the center portion adapted to engage a front side of the pipe flange and to seal the pipe opening. The peripheral skirt portion is formed to include a plurality of circumferentially spaced tabs, wherein free ends of the flexible tabs are formed with respective through passages adapted to receive a drawstring for pulling the tabs together on a back side of the pipe flange.

  14. Relevance, Derogation and Permission

    NASA Astrophysics Data System (ADS)

    Stolpe, Audun

    We show that a recently developed theory of positive permission based on the notion of derogation is hampered by a triviality result that indicates a problem with the underlying full-meet contraction operation. We suggest a solution that presupposes a particular normal form for codes of norms, adapted from the theory of relevance through propositional letter sharing. We then establish a correspondence between contractions on sets of norms in input/output logic (derogations), and AGM-style contractions on sets of formulae, and use it as a bridge to migrate results on propositional relevance from the latter to the former idiom. Changing the concept accordingly we show that positive permission now incorporates a relevance requirement that wards off triviality.

  15. Instrument measures cloud cover

    NASA Technical Reports Server (NTRS)

    Laue, E. G.

    1981-01-01

    Eight solar sensing cells comprise inexpensive monitoring instrument. Four cells always track Sun while other four face sky and clouds. On overcast day, cloud-irradiance sensors generate as much short-circuit current as Sun sensor cells. As clouds disappear, output of cloud sensors decreases. Ratio of two sensor type outputs determines fractional cloud cover.

  16. Issue Cover (September 2016).

    PubMed

    2016-09-01

    Cover legend: Macrophages phagocytosing RFP-labeled E.coli. GFP-APPL2 labels the phagosomal membrane. Image produced by N. Condon. See Yeo et al. Traffic 2016; 17(9):1014-1026. Read the full article on doi:10.1111/tra.12415. PMID:27510703

  17. Success with cover crops

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cover crops are an important tool for producers interested in improving soil and crop productivity. They help control erosion, improve soil quality, improve soil properties that impact water infiltration and conservation, provide habitat and food for beneficial insects, and provide food for wildlif...

  18. Issue Cover (June 2016).

    PubMed

    2016-06-01

    Cover legend: Yeast cells were labeled with the fluorescent viability dyes propidium iodide (Red) and DiBAC4(3) (green) and the nucleus was stained with DAPI (blue). Cells were visualized using wide-field fluorescent microscopy. See Chadwick et al. Traffic 2016; 17(6):689-703. Read the full article on doi:10.1111/tra.12391. PMID:27174376

  19. Covering All Options

    ERIC Educational Resources Information Center

    Kennedy, Mike

    2011-01-01

    The day a school opens its doors for the first time, the flooring will be new and untarnished. When the flooring is in such pristine condition, many flooring materials--carpeting, vinyl, terrazzo, wood or some other surface--will look good. But school and university planners who decide what kind of material covers the floors of their facilities…

  20. Relevance of fruits, vegetables and flavonoids from fruits and vegetables during early life, mid-childhood and adolescence for levels of insulin-like growth factor (IGF-1) and its binding proteins IGFBP-2 and IGFBP-3 in young adulthood.

    PubMed

    Krupp, Danika; Remer, Thomas; Penczynski, Katharina J; Bolzenius, Katja; Wudy, Stefan A; Buyken, Anette E

    2016-02-14

    The growth hormone (GH) insulin-like growth factor (IGF) axis has been linked to insulin metabolism and cancer risk. Experimental evidence indicates that the GH-IGF axis itself can be influenced by dietary flavonoids. As fruit and vegetable (FV) intake is a major source of flavonoid consumption, FV's beneficial health effects may be explained via flavonoids' influence on the GH-IGF axis, but observational evidence is currently rare. We used data from Dortmund Nutritional and Anthropometric Longitudinally Designed Study participants to analyse prospective associations between FV, fruit intake and flavonoid intake from FV (FlavFV) with IGF-1 and its binding proteins IGFBP-2 and IGFBP-3. Subjects needed to provide a fasting blood sample in adulthood (18-39 years) and at least two 3-d weighed dietary records in early life (0·5-2 years, n 191), mid-childhood (3-7 years, n 265) or adolescence (girls: 9-15 years, boys: 10-16 years, n 261). Additional analyses were conducted among those providing at least three 24-h urine samples in adolescence (n 236) to address the predictor urinary hippuric acid (HA), a biomarker of polyphenol intake. Higher fruit intake in mid-childhood and adolescence was related to higher IGFBP-2 in adulthood (P=0·03 and P=0·045). Comparable trends (P=0·045-0·09) were discernable for FV intake (but not FlavFV) in all three time windows. Similarly, higher adolescent HA excretion tended to be related (P=0·06) to higher adult IGFBP-2 levels. Regarding IGFBP-3, a marginal (P=0·08) positive association was observed with FlavFV in mid-childhood only. None of the investigated dietary factors was related to IGF-1. In conclusion, higher fruit and FV intakes during growth may be relevant for adult IGFBP-2, but probably not for IGFBP-3 or IGF-1. PMID:26628272

  1. Accelerated carbonation of steel slags in a landfill cover construction

    SciTech Connect

    Diener, S.; Andreas, L.; Herrmann, I.; Ecke, H.; Lagerkvist, A.

    2010-01-15

    Steel slags from high-alloyed tool steel production were used in a full scale cover construction of a municipal solid waste (MSW) landfill. In order to study the long-term stability of the steel slags within the final cover, a laboratory experiment was performed. The effect on the ageing process, due to i.e. carbonation, exerted by five different factors resembling both the material characteristics and the environmental conditions is investigated. Leaching behaviour, acid neutralization capacity and mineralogy (evaluated by means of X-ray diffraction, XRD, and thermogravimetry/differential thermal analysis, TG/DTA) are tested after different periods of ageing under different conditions. Samples aged for 3 and 10 months were evaluated in this paper. Multivariate data analysis was used for data evaluation. The results indicate that among the investigated factors, ageing time and carbon dioxide content of the atmosphere were able to exert the most relevant effect. However, further investigations are required in order to clarify the role of the temperature.

  2. Blending Rigor and Relevance

    ERIC Educational Resources Information Center

    Siri, Diane K.; Zinner, Jane; Lezin, Nicole

    2011-01-01

    A collaborative at several sites across the state of California will offer evidence of how successful linked learning, which connects academics to real-world work, can be. This article presents examples that illustrate the powerful connections and linkages that are generated by combining academic rigor with the relevance of applying learning to…

  3. Is Information Still Relevant?

    ERIC Educational Resources Information Center

    Ma, Lia

    2013-01-01

    Introduction: The term "information" in information science does not share the characteristics of those of a nomenclature: it does not bear a generally accepted definition and it does not serve as the bases and assumptions for research studies. As the data deluge has arrived, is the concept of information still relevant for information…

  4. The Relevance of Literature.

    ERIC Educational Resources Information Center

    Dunham, L. L.

    1971-01-01

    The "legacy" of the humanities is discussed in terms of relevance, involvement, and other philosophical considerations. Reasons for studying foreign literature in language classes are developed in the article. Comment is also made on attitudes and ideas culled from the writings of Clifton Fadiman, Jean Paul Sartre, and James Baldwin. (RL)

  5. Reading, Writing and Relevance.

    ERIC Educational Resources Information Center

    Hoffman, Mary

    This monograph presents classroom activities that were designed to encourage children to read and write in a self-reliant and responsible manner. The activities were chosen for their relevance to the children involved and because the vocabulary involved was interesting, familiar, and worth remembering and using again. The topics are arranged in…

  6. Streptococcus pyogenes biofilms—formation, biology, and clinical relevance

    PubMed Central

    Fiedler, Tomas; Köller, Thomas; Kreikemeyer, Bernd

    2015-01-01

    Streptococcus pyogenes (group A streptococci, GAS) is an exclusive human bacterial pathogen. The virulence potential of this species is tremendous. Interactions with humans range from asymptomatic carriage over mild and superficial infections of skin and mucosal membranes up to systemic purulent toxic-invasive disease manifestations. Particularly the latter are a severe threat for predisposed patients and lead to significant death tolls worldwide. This places GAS among the most important Gram-positive bacterial pathogens. Many recent reviews have highlighted the GAS repertoire of virulence factors, regulators and regulatory circuits/networks that enable GAS to colonize the host and to deal with all levels of the host immune defense. This covers in vitro and in vivo studies, including animal infection studies based on mice and more relevant, macaque monkeys. It is now appreciated that GAS, like many other bacterial species, do not necessarily exclusively live in a planktonic lifestyle. GAS is capable of microcolony and biofilm formation on host cells and tissues. We are now beginning to understand that this feature significantly contributes to GAS pathogenesis. In this review we will discuss the current knowledge on GAS biofilm formation, the biofilm-phenotype associated virulence factors, regulatory aspects of biofilm formation, the clinical relevance, and finally contemporary treatment regimens and future treatment options. PMID:25717441

  7. Issue Cover (July 2016).

    PubMed

    2016-07-01

    Cover legend: N-cadherin clusters colocalize with Rab5 at the macropinosomes. Confocal microscopy image of an Ncad-GFP (green) transfected COS7 cell fed with fluorescent-dextran to label macropinosomes (blue) followed by immunofluorescence staining of Rab5 (red) and the nucleus (cyan). See Wen et al. Traffic 2016; 17(7):769-785. Read the full article on doi: 10.1111/tra.12402. PMID:27297702

  8. Complex mixtures: relevance of combined exposure to substances at low dose levels.

    PubMed

    Leeman, Winfried R; Krul, Lisette; Houben, Geert F

    2013-08-01

    Upon analysis of chemically complex food matrices a forest of peaks is likely to be found. Identification of these peaks and concurrent determination of the toxicological relevance upon exposure is very time consuming, expensive and often requires animal studies. Recently, a safety assessment framework based on the Threshold of Toxicological Concern (TTC) was published to assess the safety of chemically complex matrices more efficiently. In this safety assessment framework, the toxicological relevance of exposure to unidentified substances in chemically complex food matrices can be related to the Cramer class III TTC threshold, currently set at 90 μg/day. However, possible additive or synergistic effects of combined exposure is not covered. The current evaluation describes the relevance of combined low dose exposure to unidentified substances in chemically complex food matrices. It is concluded that to some extent cumulative effects at exposure levels for each substance at or below the Cramer class III TTC threshold, being present in a complex mixture including food, might occur. However the health relevance of possible cumulative effects at this dose level is considered to be that low that a need for a correction factor to cover possible cumulative effects is very low to absent. PMID:23597445

  9. Issue Cover (August 2016).

    PubMed

    2016-08-01

    Cover legend: Absence of the novel endolysosomal trafficking regulator WDR81 (green) induces the accumulation of tetherin (red) in enlarged early endosomes. WDR81 knock-out HeLa cells were genetically complemented with an HA-tagged WDR81 construct and imaged by confocal immunofluorescence microscopy. The original image was processed with photo editing software and overlaid with artistic effects. See Rapiteanu et al. Traffic 2016; 17(8):940-958. Read the full article on doi: 10.1111/tra.12409. PMID:27412792

  10. Issue Cover (May 2016).

    PubMed

    2016-05-01

    Cover legend: Distribution of organelles that bound TYRP1-FKBP-mCherry (red) and mitochondria revealed with MitoTracker Deep Red dye (green) in the cytoplasm of a Xenopus melanophore. Rezaul et al. show TYRP1-FKBP-mCherry specifically binds to pigment granules and in the presence of rapalog recruits exogenous microtubule motor protein kinesin-1-EGFP-FRB, which changes net direction of granule movement. See Rezaul et al Traffic 2016; 17(5):475-486. Read the full article on doi:10.1111/tra.12385. PMID:27093334

  11. Morally relevant potential.

    PubMed

    Hershenov, David B; Hershenov, Rose J

    2015-03-01

    Fetuses and infants are said to warrant protecting because of their potential. But valuing potential supposedly leads to absurdities like protecting cells that could be technologically altered to develop into persons. This can be avoided by recognising that morally relevant potential is determined by what is presently healthy development (proper functioning) for an organism. The only interests of mindless organisms are in the flourishing that necessarily depends upon their healthy functioning. They can be harmed when those interests are frustrated. We criticise McMahan for claiming that harm is instead a function of the degree of psychological ties to the future. PMID:24570396

  12. Graphical methods for evaluating covering arrays

    DOE PAGESBeta

    Kim, Youngil; Jang, Dae -Heung; Anderson-Cook, Christine M.

    2016-06-01

    Covering arrays relax the condition of orthogonal arrays by only requiring that all combination of levels be covered but not requiring that the appearance of all combination of levels be balanced. This allows for a much larger number of factors to be simultaneously considered but at the cost of poorer estimation of the factor effects. To better understand patterns between sets of columns and evaluate the degree of coverage to compare and select between alternative arrays, we suggest several new graphical methods that show some of the patterns of coverage for different designs. As a result, these graphical methods formore » evaluating covering arrays are illustrated with a few examples.« less

  13. Cover Image, Volume 14, Issue 2.

    PubMed

    Finotello, R; Ressel, L; Arvigo, M; Baroni, G; Marchetti, V; Romanelli, G; Burrow, R; Mignacca, D; Blackwood, L

    2016-06-01

    The cover image, by Riccardo Finotello et al., is based on the Original Article Canine pancreatic islet cell tumours secreting insulin-like growth factor type 2 (IGF-II): a rare entity, DOI: 10.1111/vco.12085. PMID:27140206

  14. VEGETATIVE COVERS FOR WASTE CONTAINMENT

    EPA Science Inventory

    Disposal of municipal ahd hazardous waste in the United States is primarily accomplished by containment in lined and capped landfills. Evapotranspiration cover systems offer an alternative to conventional landfill cap systems. These covers work on completely different principles ...

  15. Cover crops and N credits

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cover crops often provide many short- and long-term benefits to cropping systems. Legume cover crops can significantly reduce the N fertilizer requirement of non-legume cash crops that follow. The objectives of this presentation were to: I) educate stakeholders about the potential benefits of cover ...

  16. Labor Education as an Important Factor in Resolving the Problem of Making the School Relevant to Life (Based on the Example of Nationality Schools in the Siberian Far North in the 1920s and Early 1930s).

    ERIC Educational Resources Information Center

    Shirshova, O. P.

    1981-01-01

    Describes the development of rural Siberian polytechnical education during the 1920s. To fulfill the demands of economic development and the need for relevant education, polytechnical education centers were set up to train students in hunting and fishing, agriculture, skilled trades, and meteorology, as well as teaching, social work, and…

  17. Timer cover adhesive optimization

    SciTech Connect

    Carleton, J.J. II.

    1992-03-17

    The implementation of PROCODE as the data acquisition system for processing timers has required some modifications to the method of identifying timer assemblies. PROCODE requires machine-readable labelling of the assemblies. This report describes a series of experiments to find an adhesive that would keep labels attached to timers regardless of the condition of their surface when the label was applied and regardless of the heat, vibration, and shock they endured afterwards. The effect of the variation of these experimental factors on the performance of the adhesive was determined by using a Taguchi experimental design.

  18. Absence of snow cover reduces understory plant cover and alters plant community composition in boreal forests.

    PubMed

    Kreyling, Juergen; Haei, Mahsa; Laudon, Hjalmar

    2012-02-01

    Snow regimes affect biogeochemistry of boreal ecosystems and are altered by climate change. The effects on plant communities, however, are largely unexplored despite their influence on relevant processes. Here, the impact of snow cover on understory community composition and below-ground production in a boreal Picea abies forest was investigated using a long-term (8-year) snow cover manipulation experiment consisting of the treatments: snow removal, increased insulation (styrofoam pellets), and control. The snow removal treatment caused longer (118 vs. 57 days) and deeper soil frost (mean minimum temperature -5.5 vs. -2.2°C) at 10 cm soil depth in comparison to control. Understory species composition was strongly altered by the snow cover manipulations; vegetation cover declined by more than 50% in the snow removal treatment. In particular, the dominant dwarf shrub Vaccinium myrtillus (-82%) and the most abundant mosses Pleurozium schreberi (-74%) and Dicranum scoparium (-60%) declined strongly. The C:N ratio in V. myrtillus leaves and plant available N in the soil indicated no altered nitrogen nutrition. Fine-root biomass in summer, however, was negatively affected by the reduced snow cover (-50%). Observed effects are attributed to direct frost damage of roots and/ or shoots. Besides the obvious relevance of winter processes on plant ecology and distribution, we propose that shifts in the vegetation caused by frost damage may be an important driver of the reported alterations in biogeochemistry in response to altered snow cover. Understory plant performance clearly needs to be considered in the biogeochemistry of boreal systems in the face of climate change. PMID:21850524

  19. Some Results on Incremental Vertex Cover Problem

    NASA Astrophysics Data System (ADS)

    Dai, Wenqiang

    In the classical k-vertex cover problem, we wish to find a minimum weight set of vertices that covers at least k edges. In the incremental version of the k-vertex cover problem, we wish to find a sequence of vertices, such that if we choose the smallest prefix of vertices in the sequence that covers at least k edges, this solution is close in value to that of the optimal k-vertex cover solution. The maximum ratio is called competitive ratio. Previously the known upper bound of competitive ratio was 4α, where α is the approximation ratio of the k-vertex cover problem. And the known lower bound was 1.36 unless P = NP, or 2 - ɛ for any constant ɛ assuming the Unique Game Conjecture. In this paper we present some new results for this problem. Firstly we prove that, without any computational complexity assumption, the lower bound of competitive ratio of incremental vertex cover problem is φ, where φ=sqrt{5}+1/2≈ 1.618 is the golden ratio. We then consider the restricted versions where k is restricted to one of two given values(Named 2-IVC problem) and one of three given values(Named 3-IVC problem). For 2-IVC problem, we give an algorithm to prove that the competitive ratio is at most φα. This incremental algorithm is also optimal for 2-IVC problem if we are permitted to use non-polynomial time. For the 3-IVC problem, we give an incremental algorithm with ratio factor (1+sqrt{2})α.

  20. Judging Books by Their Covers: A Cover Art Experiment.

    ERIC Educational Resources Information Center

    Sullivan, Edward T.

    1998-01-01

    A group of 21 young adults (11-17) were asked to rate books by their cover art only and write explanations for their ratings. Discusses ratings and their rationales and concludes that the participants expected a cover to give them an idea of what a story was about. Includes a list of the books evaluated. (PEN)

  1. Cooling vests with phase change material packs: the effects of temperature gradient, mass and covering area.

    PubMed

    Gao, Chuansi; Kuklane, Kalev; Holmer, Ingvar

    2010-05-01

    Phase change material (PCM) absorbs or releases latent heat when it changes phases, making thermal-regulated clothing possible. The objective of this study was to quantify the relationships between PCM cooling rate and temperature gradient, mass and covering area on a thermal manikin in a climatic chamber. Three melting temperatures (24, 28, 32 degrees C) of the PCMs, different mass, covering areas and two manikin temperatures (34 and 38 degrees C) were used. The results showed that the cooling rate of the PCM vests tested is positively correlated with the temperature gradient between the thermal manikin and the melting temperature of the PCMs. The required temperature gradient is suggested to be greater than 6 degrees C when PCM vests are used in hot climates. With the same temperature gradient, the cooling rate is mainly determined by the covering area. The duration of the cooling effect is dependent on PCM mass and the latent heat. STATEMENT OF RELEVANCE: The study of factors affecting the cooling rate of personal cooling equipment incorporated with PCM helps to understand cooling mechanisms. The results suggest climatic conditions, the required temperature gradient, PCM mass and covering area should be taken into account when choosing personal PCM cooling equipment. PMID:20432090

  2. "Proximal Sensing" capabilities for snow cover monitoring

    NASA Astrophysics Data System (ADS)

    Valt, Mauro; Salvatori, Rosamaria; Plini, Paolo; Salzano, Roberto; Giusti, Marco; Montagnoli, Mauro; Sigismondi, Daniele; Cagnati, Anselmo

    2013-04-01

    The seasonal snow cover represents one of the most important land cover class in relation to environmental studies in mountain areas, especially considering its variation during time. Snow cover and its extension play a relevant role for the studies on the atmospheric dynamics and the evolution of climate. It is also important for the analysis and management of water resources and for the management of touristic activities in mountain areas. Recently, webcam images collected at daily or even hourly intervals are being used as tools to observe the snow covered areas; those images, properly processed, can be considered a very important environmental data source. Images captured by digital cameras become a useful tool at local scale providing images even when the cloud coverage makes impossible the observation by satellite sensors. When suitably processed these images can be used for scientific purposes, having a good resolution (at least 800x600x16 million colours) and a very good sampling frequency (hourly images taken through the whole year). Once stored in databases, those images represent therefore an important source of information for the study of recent climatic changes, to evaluate the available water resources and to analyse the daily surface evolution of the snow cover. The Snow-noSnow software has been specifically designed to automatically detect the extension of snow cover collected from webcam images with a very limited human intervention. The software was tested on images collected on Alps (ARPAV webcam network) and on Apennine in a pilot station properly equipped for this project by CNR-IIA. The results obtained through the use of Snow-noSnow are comparable to the one achieved by photo-interpretation and could be considered as better as the ones obtained using the image segmentation routine implemented into image processing commercial softwares. Additionally, Snow-noSnow operates in a semi-automatic way and has a reduced processing time. The analysis

  3. Cover crops and vegetable rotations

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Farmers have long known that winter cover crops can decrease soil erosion, increase soil organic matter and fertility, and provide a beneficial impact on the following crop, but it is not always known which cover crop will provide the best results for a specific region and cropping system. Research...

  4. Midwest Cover Crops Field Guide

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Producers who want to prevent soil erosion, improve nutrient cycling, sustain their soils, and protect/maintain the environment have been returning to a very old practice: planting cover crops. Cover crops are effective tools for reducing soil erosion and increasing nutrient recycling on farmlands, ...

  5. High plains cover crop research

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Some recent statements have been made about the benefits of growing cover crops in mixtures as compared with single-species plantings of cover crops. Those stated benefits have included greatly reduced water use, enhanced soil microbiological activity, increased biomass productivity, and enhanced wa...

  6. Set covering, partition and packing

    SciTech Connect

    Hulme, B.L.; Baca, L.S.

    1984-03-01

    Set covering problems are known to be solvable by Boolean algebraic methods. This report shows that set partition and set packing problems can be solved by the same algebraic methods because these problems can be converted into covering problems. Many applications are possible including security patrol assignment which is used as an example.

  7. Corn Belt Assessment of Cover Crop Management and Preferences

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Surveying end-users about their use of technologies and preferences provides information for researchers and educators to develop relevant research and educational programs. A mail survey was sent to Corn Belt farmers during 2006 to quantify cover crop management and preferences. Results indicated t...

  8. Automatic design of magazine covers

    NASA Astrophysics Data System (ADS)

    Jahanian, Ali; Liu, Jerry; Tretter, Daniel R.; Lin, Qian; Damera-Venkata, Niranjan; O'Brien-Strain, Eamonn; Lee, Seungyon; Fan, Jian; Allebach, Jan P.

    2012-03-01

    In this paper, we propose a system for automatic design of magazine covers that quantifies a number of concepts from art and aesthetics. Our solution to automatic design of this type of media has been shaped by input from professional designers, magazine art directors and editorial boards, and journalists. Consequently, a number of principles in design and rules in designing magazine covers are delineated. Several techniques are derived and employed in order to quantify and implement these principles and rules in the format of a software framework. At this stage, our framework divides the task of design into three main modules: layout of magazine cover elements, choice of color for masthead and cover lines, and typography of cover lines. Feedback from professional designers on our designs suggests that our results are congruent with their intuition.

  9. Relevancy in Vocational Education (A Collection of Essays).

    ERIC Educational Resources Information Center

    Ediger, Marlow

    This collection of seven essays covers the subject of relevance in vocational education from several perspectives. Topics of the essays are the following: (1) vocational education and the curriculum; (2) the counselor and vocational education; (3) vocational education and employability skills; (4) student reentry into the curriculum; (5) remedying…

  10. Controlling for causally relevant third variables.

    PubMed

    Goodie, Adam S; Williams, Cristina C; Crooks, C L

    2003-10-01

    In 3 experiments, the authors tested the conditions under which 3rd variables are controlled for in making causal judgments. The authors hypothesized that 3rd variables are controlled for when the 3rd variables are themselves perceived as causal. In Experiment 1, the participants predicted test performance after seeing information about wearing a lucky garment, taking a test-preparation course, and staying up late. The course (perceived as more causally relevant) was controlled for more than was the garment (perceived as less causally relevant) in assessing the effectiveness of staying up late. In Experiments 2 and 3, to obviate the many alternative accounts that arise from the realistic cover story of Experiment 1, participants predicted flowers' blooming after the presentation or nonpresentation of liquids. When one liquid was trained as causal, it was controlled for more in judging another liquid than when it was trained as neutral. Overall, stimuli perceived as causal were controlled for more when judging other stimuli. The authors concluded that the effect of perceived causal relevance on causal conditionalizing is real and normatively reasonable. PMID:14672103

  11. Cover Image, Volume 117, Number 7, July 2016.

    PubMed

    Al-Dujaili, Saja A; Koh, Amy J; Dang, Ming; Mi, Xue; Chang, Wenhan; Ma, Peter X; McCauley, Laurie K

    2016-07-01

    Cover: The cover image, by Laurie K. McCauley et al., is based on the Article Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co-Factor in PTH Anabolic Actions in Bone, DOI: 10.1002/jcb.25447. PMID:27145428

  12. MODIS Vegetative Cover Conversion and Vegetation Continuous Fields

    NASA Astrophysics Data System (ADS)

    Carroll, Mark; Townshend, John; Hansen, Matthew; DiMiceli, Charlene; Sohlberg, Robert; Wurster, Karl

    Land cover change occurs at various spatial and temporal scales. For example, large-scale mechanical removal of forests for agro-industrial activities contrasts with the small-scale clearing of subsistence farmers. Such dynamics vary in spatial extent and rate of land conversion. Such changes are attributable to both natural and anthropogenic factors. For example, lightning- or human-ignited fires burn millions of acres of land surface each year. Further, land cover conversion requires ­contrasting with the land cover modification. In the first instance, the dynamic represents extensive categorical change between two land cover types. Land cover modification mechanisms such as selective logging and woody encroachment depict changes within a given land cover type rather than a conversion from one land cover type to another. This chapter describes the production of two standard MODIS land products used to document changes in global land cover. The Vegetative Cover Conversion (VCC) product is designed primarily to serve as a global alarm for areas where land cover change occurs rapidly (Zhan et al. 2000). The Vegetation Continuous Fields (VCF) product is designed to continuously ­represent ground cover as a proportion of basic vegetation traits. Terra's launch in December 1999 afforded a new opportunity to observe the entire Earth every 1.2 days at 250-m spatial resolution. The MODIS instrument's appropriate spatial and ­temporal resolutions provide the opportunity to substantially improve the characterization of the land surface and changes occurring thereupon (Townshend et al. 1991).

  13. Exploring Global Exposure Factors Resources for Use in Consumer Exposure Assessments

    PubMed Central

    Zaleski, Rosemary T.; Egeghy, Peter P.; Hakkinen, Pertti J.

    2016-01-01

    This publication serves as a global comprehensive resource for readers seeking exposure factor data and information relevant to consumer exposure assessment. It describes the types of information that may be found in various official surveys and online and published resources. The relevant exposure factors cover a broad range, including general exposure factor data found in published compendia and databases and resources about specific exposure factors, such as human activity patterns and housing information. Also included are resources on exposure factors related to specific types of consumer products and the associated patterns of use, such as for a type of personal care product or a type of children’s toy. Further, a section on using exposure factors for designing representative exposure scenarios is included, along with a look into the future for databases and other exposure science developments relevant for consumer exposure assessment. PMID:27455300

  14. Exploring Global Exposure Factors Resources for Use in Consumer Exposure Assessments.

    PubMed

    Zaleski, Rosemary T; Egeghy, Peter P; Hakkinen, Pertti J

    2016-01-01

    This publication serves as a global comprehensive resource for readers seeking exposure factor data and information relevant to consumer exposure assessment. It describes the types of information that may be found in various official surveys and online and published resources. The relevant exposure factors cover a broad range, including general exposure factor data found in published compendia and databases and resources about specific exposure factors, such as human activity patterns and housing information. Also included are resources on exposure factors related to specific types of consumer products and the associated patterns of use, such as for a type of personal care product or a type of children's toy. Further, a section on using exposure factors for designing representative exposure scenarios is included, along with a look into the future for databases and other exposure science developments relevant for consumer exposure assessment. PMID:27455300

  15. Fluorescence imaging to quantify crop residue cover

    NASA Technical Reports Server (NTRS)

    Daughtry, C. S. T.; Mcmurtrey, J. E., III; Chappelle, E. W.

    1994-01-01

    Crop residues, the portion of the crop left in the field after harvest, can be an important management factor in controlling soil erosion. Methods to quantify residue cover are needed that are rapid, accurate, and objective. Scenes with known amounts of crop residue were illuminated with long wave ultraviolet (UV) radiation and fluorescence images were recorded with an intensified video camera fitted with a 453 to 488 nm band pass filter. A light colored soil and a dark colored soil were used as background for the weathered soybean stems. Residue cover was determined by counting the proportion of the pixels in the image with fluorescence values greater than a threshold. Soil pixels had the lowest gray levels in the images. The values of the soybean residue pixels spanned nearly the full range of the 8-bit video data. Classification accuracies typically were within 3(absolute units) of measured cover values. Video imaging can provide an intuitive understanding of the fraction of the soil covered by residue.

  16. Effect of ice cover on hydropower production

    SciTech Connect

    Yapa, P.D.; Shen H.T.

    1984-09-01

    For hydropower developments in northern regions, the annual occurrence of river ice cover presents various problems of operation and management. The existence of an ice cover can lead to a substantial loss in power production. This loss in power due to the presence of ice cover, however, can be minimized with appropriate ice control measures. In this technical note, a quantitative analysis of power loss is carried out for the St. Lawrence Power Project. Major factors that affect the magnitude of power loss are examined to provide some information for future ice-related hydropower operations. The St. Lawrence River, which conveys water from the Great Lakes Basin to the Atlantic Ocean, has been utilized for hydroelectric power production since the early 1900's. The St. Lawrence Seaway and Power Project, constructed in 1954-58, developed the hydropower potential of the upper St. Lawrence River. The Moses-Saunders Power Dam is located about 100 miles downstream of the outlet of Lake Ontario. Since the development of this power project, the regulation of flow through the dam in relation to the ice conditions has been an important element in its winter operation. The existence of an ice cover reduces the power production capability of the river significantly.

  17. Monitoring urban land cover change by updating the national land cover database impervious surface products

    USGS Publications Warehouse

    Xian, G.; Homer, C.

    2009-01-01

    The U.S. Geological Survey (USGS) National Land Cover Database (NLCD) 2001 is widely used as a baseline for national land cover and impervious conditions. To ensure timely and relevant data, it is important to update this base to a more recent time period. A prototype method was developed to update the land cover and impervious surface by individual Landsat path and row. This method updates NLCD 2001 to a nominal date of 2006 by using both Landsat imagery and data from NLCD 2001 as the baseline. Pairs of Landsat scenes in the same season from both 2001 and 2006 were acquired according to satellite paths and rows and normalized to allow calculation of change vectors between the two dates. Conservative thresholds based on Anderson Level I land cover classes were used to segregate the change vectors and determine areas of change and no-change. Once change areas had been identified, impervious surface was estimated for areas of change by sampling from NLCD 2001 in unchanged areas. Methods were developed and tested across five Landsat path/row study sites that contain a variety of metropolitan areas. Results from the five study areas show that the vast majority of impervious surface changes associated with urban developments were accurately captured and updated. The approach optimizes mapping efficiency and can provide users a flexible method to generate updated impervious surface at national and regional scales. ?? 2009 IEEE.

  18. Dimensions and Dimension Relevance in LPC Selection and Evaluation.

    ERIC Educational Resources Information Center

    Downey, Ronald G.; Kirkeide, Loren

    Many criticisms of Fiedler's contingency model focus upon the LPC (Least Preferred Coworker) scale. The characteristics of the LPC scale were investigated in two studies. Experiment 1 focused upon determining the factor structure of LPC and relevance ratings, while Experiment 2 dealt with relationships among LPC, relevance, and self-ratings.…

  19. Using a Mixed Methods Sequential Design to Identify Factors Associated with African American Mothers' Intention to Vaccinate Their Daughters Aged 9 to 12 for HPV with a Purpose of Informing a Culturally-Relevant, Theory-Based Intervention

    ERIC Educational Resources Information Center

    Cunningham, Jennifer L.

    2013-01-01

    The purpose of this sequential, explanatory mixed methods research study was to understand what factors influenced African American maternal intentions to get their daughters aged 9 years to 12 years vaccinated in Alabama. In the first, quantitative phase of the study, the research questions focused on identifying the predictive power of eleven…

  20. LANDFILL CONTAINMENT AND COVER SYSTEMS

    EPA Science Inventory

    The U.S. Environmental Protection Agency through its research and field experiences has developed control strategies for hazardous and municipal solid waste landfills and surface impoundments. hese control strategies include liner and cover systems. he liner systems include doubl...

  1. Land-cover change detection

    USGS Publications Warehouse

    Chen, Xuexia; Giri, Chandra; Vogelmann, James

    2012-01-01

    Land cover is the biophysical material on the surface of the earth. Land-cover types include grass, shrubs, trees, barren, water, and man-made features. Land cover changes continuously.  The rate of change can be either dramatic and abrupt, such as the changes caused by logging, hurricanes and fire, or subtle and gradual, such as regeneration of forests and damage caused by insects (Verbesselt et al., 2001).  Previous studies have shown that land cover has changed dramatically during the past sevearal centuries and that these changes have severely affected our ecosystems (Foody, 2010; Lambin et al., 2001). Lambin and Strahlers (1994b) summarized five types of cause for land-cover changes: (1) long-term natural changes in climate conditions, (2) geomorphological and ecological processes, (3) human-induced alterations of vegetation cover and landscapes, (4) interannual climate variability, and (5) human-induced greenhouse effect.  Tools and techniques are needed to detect, describe, and predict these changes to facilitate sustainable management of natural resources.

  2. Dielectronic recombination for oxygenlike ions relevant to astrophysical applications

    NASA Astrophysics Data System (ADS)

    Chen, M. H.

    2002-11-01

    In the modeling of the astrophysical plasmas, the relative elemental abundance inferred from solar and stellar upper atmosphere can be affected by as much as a factor of 5 due to the uncertainties in the current dielectronic recombination (DR) rate coefficients used to analyze the spectra [Savin and Laming, Astrophys. J. 566, 1166 (2002)]. DR rate coefficients for oxygenlike ions have been identified as the most urgent needs for the astrophysical applications. In this work, we report on the calculations of DR rate coefficients for Mg V, Si VII, S IX, and Fe XIX ions which are important for the modeling of the astrophysical plasmas. The calculations are carried out in isolated resonance and distorted-wave approximations. The relevant atomic data are calculated using the multiconfigurational Dirac-Fock method. We include 2s-2p, 2p1/2-2p3/2, 2l-3l', and 1s-2p excitations and cover temperatures ranging from 0.001 eV to 10 000 eV. For low temperatures, it is essential to have accurate DR resonance energies and to include fine-structure excitations in order to obtain reliable DR rate coefficients. Good agreement with experiment has been found for Fe XIX. For Mg V, Si VII, and S IX, significant discrepancies are noted between this work and recommended rate coefficients.

  3. Observations on mattress covers: results of a pilot study.

    PubMed

    Thomas, S

    1998-01-01

    Samples of covers from three commercially available mattresses were examined in the laboratory using test methods originally devised for testing surgical dressings. These revealed that although the covers shared many common features, there were differences in the conformability and tensile properties which may be of some clinical relevance. The study also confirmed that with some minor modifications, the experimental techniques used would be suitable for a future, more comprehensive review of mattress performance. In a separate investigation designed to examine the consequences of a failure of a mattress cover, the bioburden of a foam core removed from a damaged cover revealed the presence of very large numbers of microorganism, well in excess of 10(10) per gram of foam which could act as a recevoir of contamination and thus a source of cross infection. PMID:10531919

  4. Estimation of vegetation cover at subpixel resolution using LANDSAT data

    NASA Technical Reports Server (NTRS)

    Jasinski, Michael F.; Eagleson, Peter S.

    1986-01-01

    The present report summarizes the various approaches relevant to estimating canopy cover at subpixel resolution. The approaches are based on physical models of radiative transfer in non-homogeneous canopies and on empirical methods. The effects of vegetation shadows and topography are examined. Simple versions of the model are tested, using the Taos, New Mexico Study Area database. Emphasis has been placed on using relatively simple models requiring only one or two bands. Although most methods require some degree of ground truth, a two-band method is investigated whereby the percent cover can be estimated without ground truth by examining the limits of the data space. Future work is proposed which will incorporate additional surface parameters into the canopy cover algorithm, such as topography, leaf area, or shadows. The method involves deriving a probability density function for the percent canopy cover based on the joint probability density function of the observed radiances.

  5. The Ugandan Youth Quality of Life index: assessing the relevance of incorporating perceived importance into the quality of life measure and factors associated with the quality of life among youth in slum areas of Kampala, Uganda

    PubMed Central

    Renzaho, Andre M. N.; Kamara, Joseph Kihika; Kamanga, Gilbert

    2016-01-01

    Background While quality of life (QoL) has long been an explicit policy goal for international development programmes, no instruments have specifically been developed for measuring health-related QoL in resource-limited settings. The aim of this study was to develop and validate a QoL instrument for use in international aid and development programmes and to assess factors associated with QoL among youth participating in a civic engagement project in Kampala. Design Using systematic random sampling, data were collected on 663 participants aged between 13 and 24 years in Kampala. The QoL questionnaire included 36 questions divided into a two-part scale: 18 questions rated for satisfaction (Part 1) and 18 other questions rated on importance (Part 2). The total sample was randomly divided into two split-half samples: one for the exploratory factor analysis (EFA; N=310) and the other for the confirmatorty factor analysis (CFA; N=353). The effect of demographic, socio-economic, and lifestyle factors on QoL was assessed using linear regressions. Results The EFA yielded three factors: living conditions and lifestyle (seven items, α=0.84), social relationships (five items, α=0.86), and personal independence (five items, α=0.76). In the CFA, the initial model demonstrated a poor to marginal fit model. Its re-specification by examining modification indices resulted in a good model fit: Comparative Fit Index=0.95, Root Mean Square Error of Approximation=0.06, and p of Close Fit >0.05. The model incorporating perceived importance had lower Akaike Information Criteria and Bayesian Information Criteria values than the unweighted model, thereby providing very strong support to weight satisfaction scores with importance ratings when measuring QoL in Uganda. Poor QoL was associated with poor educational attainment, drug and substance misuse, and family disruption. Conclusions The findings suggest that there is a relationship between QoL and lifestyle and structural issues among

  6. Relevance theory: pragmatics and cognition.

    PubMed

    Wearing, Catherine J

    2015-01-01

    Relevance Theory is a cognitively oriented theory of pragmatics, i.e., a theory of language use. It builds on the seminal work of H.P. Grice(1) to develop a pragmatic theory which is at once philosophically sensitive and empirically plausible (in both psychological and evolutionary terms). This entry reviews the central commitments and chief contributions of Relevance Theory, including its Gricean commitment to the centrality of intention-reading and inference in communication; the cognitively grounded notion of relevance which provides the mechanism for explaining pragmatic interpretation as an intention-driven, inferential process; and several key applications of the theory (lexical pragmatics, metaphor and irony, procedural meaning). Relevance Theory is an important contribution to our understanding of the pragmatics of communication. PMID:26263065

  7. Thermal properties for vegetation cover

    NASA Astrophysics Data System (ADS)

    Aleksyutina, D.; Motenko, R.

    2011-12-01

    Different samples of undisturbed vegetation cover were studied under laboratory conditions. Samples were collected from New Chara city, north of the Chita region. Vegetation cover in this area is represented by moss, lichen and tussock growth. Thermal properties were investigated by the I-st type regular mode method (a-calorimeter), the freezing temperature was studied by cryoscopic methods. The dry density of sampled specimens varies from 0.04 to 0.24 g/cm3, and humidity varies from 250 to 375 percent. The freezing temperature depends on moisture content and varies from -0.2 to 0 degrees centigrade. The vegetation cover had low thermal conductivities which varies from 0.05 to 0.46 W/(m*K) in unfrozen conditions, and from 0.07 to 1.14 W/(m*K) in frozen conditions, according to density and moisture content. Diffusivity of samples varies from 0.073*10-6 to 0.114*10-6 m2/s in thawed conditions, and from 0.174*10-6 to 0.584*10-6 m2/s in frozen conditions. The sod (bottom of vegetation cover) had relatively high thermal properties. Thermal properties of vegetation cover and peat (turf) were compared. The thermal conductivity of peat was much higher than thermal conductivity of vegetation cover. This data may be used for modeling of the thickness of the seasonally thawed layer and ground temperature variation. The knowledge of thermal properties of these samples allows us to view vegetation cover as a separate layer of geological section.

  8. Expression of E1AF/PEA3, an Ets-related transcription factor in human non-small-cell lung cancers: its relevance in cell motility and invasion.

    PubMed

    Hiroumi, H; Dosaka-Akita, H; Yoshida, K; Shindoh, M; Ohbuchi, T; Fujinaga, K; Nishimura, M

    2001-09-01

    Cell invasion and metastasis characterize the malignant potential of non-small-cell lung cancers (NSCLCs). We have previously reported that E1AF, a member of the Ets-related transcription factor family, confers invasive phenotype on breast cancer and oral squamous-cell carcinoma cell lines. In our study, we analyzed the E1AF expression in cell lines and resected tumors of NSCLCs by Northern blot and in situ hybridization analyses and found that 15 of 17 cell lines and 12 of 19 tumors expressed E1AF mRNA while normal lung tissue and concomitant normal cells within tumors did not. To examine the biologic importance of E1AF in NSCLCs, we introduced the E1AF gene into VMRC-LCD and NCI-H226, NSCLC cell lines lacking E1AF expression, and examined cell motility and invasion activities. E1AF-transfected VMRC-LCD cells showed increased cell motility that was 2-fold that of parental and vector-transfected control cells (p < 0.01), and both cell motility and invasion were increased 1.6-fold in NCI-H226 (p < 0.01). Furthermore, hepatocyte growth factor (HGF), which is one of the most effective cell-scattering factors, stimulated the motile and invasive activities in E1AF-transfected VMRC-LCD and NCI-H226 cells but not in their parental or vector-transfected control cells. Ets-1 mRNA expression was found in E1AF-transfected VMRC-LCD cells but not in parental or vector-transfected cells. HGF further induced expression of the Ets-1 and urokinase-type plasminogen activator (uPA) genes specifically in E1AF-transfected cells. These findings suggest that E1AF plays a substantial role in the cell motility and invasion of NSCLCs. PMID:11519038

  9. How Scientists Differentiate Between Land Cover Types

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Before scientists can transform raw satellite image data into land cover maps, they must decide on what categories of land cover they would like to use. Categories are simply the types of landscape that the scientists are trying to map and can vary greatly from map to map. For flood maps, there may be only two categories-dry land and wet land-while a standard global land cover map may have seventeen categories including closed shrub lands, savannas, evergreen needle leaf forest, urban areas, and ice/snow. The only requirement for any land cover category is that it have a distinct spectral signature that a satellite can record. As can be seen through a prism, many different colors (wavelengths) make up the spectra of sunlight. When sunlight strikes objects, certain wavelengths are absorbed and others are reflected or emitted. The unique way in which a given type of land cover reflects and absorbs light is known as its spectral signature. Anyone who has flown over the midwestern United States has seen evidence of this phenomenon. From an airplane window, the ground appears as a patchwork of different colors formed by the fields of crops planted there. The varying pigments of the leaves, the amount of foliage per square foot, the age of the plants, and many other factors create this tapestry. Most imaging satellites are sensitive to specific wavelengths of light, including infrared wavelengths that cannot be seen with the naked eye. Passive satellite remote sensors-such as those flown on Landsat 5, Landsat 7, and Terra-have a number of light detectors (photoreceptors) on board that measure the energy reflected or emitted by the Earth. One light detector records only the blue part of the spectrum coming off the Earth. Another observes all the yellow-green light and still another picks up on all the near-infrared light. The detectors scan the Earth's surface as the satellite travels in a circular orbit very nearly from pole-to-pole. To differentiate between types of

  10. MODIS Snow-Cover Products

    NASA Technical Reports Server (NTRS)

    Hall, Dorothy K.; Riggs, George A.; Salomonson, Vinvent V.; DiGirolamo, Nicolo; Bayr, Klaus J.; Houser, Paul (Technical Monitor)

    2001-01-01

    On December 18, 1999, the Terra satellite was launched with a complement of five instruments including the Moderate Resolution Imaging Spectroradiometer (MODIS). Many geophysical products are derived from MODIS data including global snow-cover products. These products have been available through the National Snow and Ice Data Center (NSIDC) Distributed Active Archive Center (DAAC) since September 13, 2000. MODIS snow-cover products represent potential improvement to the currently available operation products mainly because the MODIS products are global and 500-m resolution, and have the capability to separate most snow and clouds. Also the snow-mapping algorithms are automated which means that a consistent data set is generated for long-term climates studies that require snow-cover information. Extensive quality assurance (QA) information is stored with the product. The snow product suite starts with a 500-m resolution swath snow-cover map which is gridded to the Integerized Sinusoidal Grid to produce daily and eight-day composite tile products. The sequence then proceeds to a climate-modeling grid product at 5-km spatial resolution, with both daily and eight-day composite products. A case study from March 6, 2000, involving MODIS data and field and aircraft measurements, is presented. Near-term enhancements include daily snow albedo and fractional snow cover.