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Sample records for requirement pmr review

  1. Status review of PMR polyimides

    NASA Technical Reports Server (NTRS)

    Serafini, T. T.

    1978-01-01

    The current status of first and second generation PMR polyimides are reviewed. Synthesis, processing, and applications were considered, using prepreg materials based on processable, high temperature resistant polyimides.

  2. PMR polyimides-review and update

    NASA Technical Reports Server (NTRS)

    Serafini, T. T.; Delvigs, P.; Alston, W. B.

    1982-01-01

    Fiber reinforced PMR polyimides are finding increased acceptance as engineering materials for high performance structural applications. Prepreg materials based on this novel class of highly processable, high temperature resistant polyimides are commercially available and the PMR concept is used by other investigators. The current status of first and second generation PMR polyimides were reviewed. Emphasis is given to the chemistry, processing and applications of the first generation material known as PMR-15.

  3. PMR6, a pectate lyase-like gene required for powdery mildew susceptibility in Arabidopsis.

    PubMed

    Vogel, John P; Raab, Theodore K; Schiff, Celine; Somerville, Shauna C

    2002-09-01

    The plant genes required for the growth and reproduction of plant pathogens are largely unknown. In an effort to identify these genes, we isolated Arabidopsis mutants that do not support the normal growth of the powdery mildew pathogen Erysiphe cichoracearum. Here, we report on the cloning and characterization of one of these genes, PMR6. PMR6 encodes a pectate lyase-like protein with a novel C-terminal domain. Consistent with its predicted gene function, mutations in PMR6 alter the composition of the plant cell wall, as shown by Fourier transform infrared spectroscopy. pmr6-mediated resistance requires neither salicylic acid nor the ability to perceive jasmonic acid or ethylene, indicating that the resistance mechanism does not require the activation of well-described defense pathways. Thus, pmr6 resistance represents a novel form of disease resistance based on the loss of a gene required during a compatible interaction rather than the activation of known host defense pathways. PMID:12215508

  4. PMR polyimide composites for aerospace applications

    NASA Technical Reports Server (NTRS)

    Serafini, T. T.

    1982-01-01

    Fiber reinforced PMR polyimides are finding increased acceptance as engineering materials for high performance structural applications. Prepreg materials based on this novel class of highly processable, high temperature resistant polyimides, are commercially available and the PMR concept was incorporated in several industrial applications. The status of PMR polyimides is reviewed. Emphasis is given to the chemistry, processing, and applications of the first generation PMR polyimides known as PMR-15.

  5. Endonuclease-mediated mRNA Decay Requires Tyrosine Phosphorylation of Polysomal Ribonuclease 1 (PMR1) for the Targeting and Degradation of Polyribosome-bound Substrate mRNA*

    PubMed Central

    Yang, Feng; Peng, Yong; Schoenberg, Daniel R.

    2006-01-01

    PMR1 is an endonuclease that is activated by estrogen to degrade Xenopus albumin mRNA. A previous report showed that the functional unit of endonuclease-mediated mRNA decay is a ~680-kDa polysome-bound complex that contains both PMR1 and substrate mRNA. PMR1 contains two domains involved in endonuclease targeting to polysomes, an N-terminal domain that lies between residues 200 and 250, and a C-terminal domain that lies within the last 100 residues. Loss of either domain inactivated PMR1 targeting to polysomes and stabilized albumin mRNA. The current study identified a phosphorylated tyrosine residue within the C-terminal polysome-targeting domain and showed that this modification is required for PMR1-mediated mRNA decay. Changing this tyrosine to phenylalanine inactivated the targeting of PMR1 to polysomes, blocked binding of PMR1 to the functional complex containing its substrate mRNA, prevented the targeting of a green fluorescent protein fusion protein to this complex, and stabilized albumin mRNA to degradation by PMR1 in vivo. A general tyrosine kinase inhibitor inhibited the phosphorylation of PMR1, which in turn inhibited PMR1-catalyzed degradation of albumin mRNA. These results indicate that one or more tyrosine kinases functions as a regulator of endonuclease-mediated mRNA decay. PMID:15375158

  6. Novel improved PMR polyimides

    NASA Technical Reports Server (NTRS)

    Pater, R. H.

    1981-01-01

    A series of N-phenylnadimide (PN) modified PMR polyimide composites reinforced with graphite fibers was investigated. The improved flow matrix resins consist of N-phenylnadimide (PN), monomenthyl ester of 5-norbornene-2, 3-dicarboxylic acid (NE), dimethyl ester of 3,3, 4,4-benzophenonetetracarboxylic acide (BTDE), and 4,4 methylenedianiline (MDA). Five modified PMR resin systems were formulated by the addition of 4 to 20 mole percent N-phenylnadimide to the standard PMR-15 composition. These formulations and the control PMR resin were evaluated for rheological characteristics. The initial thermal and mechanical properties of the PN modified PMR and the control PMR/Celion 6000 composites were determined. The results show that the addition of N-phenylnadimide to PMR-15 significantly improved the resin flow characteristics without sacrificing the composites properties. Concentrations of 4 and 9 mole percent PN appear to improve the thermoxidative stability of PMR composites.

  7. PMR polyimides from solutions containing mixed endcaps

    NASA Technical Reports Server (NTRS)

    Delvigs, P.

    1985-01-01

    Previous studies have shown that partial substitution of p-aminostyrene (PAS) for the monomethylester of endo-5-norbornene-2, 3-dicarboxylic acid (NE) lowered the cure temperature of PMR polyimides from 316 to 260 C, but the modified PMR polyimides required higher compression-molding pressures than state-of-the-art PMR-15. In this study PMR polyimides are prepared employing three encaps: NE, PAS, and endo-N-phenyl-5-norbornene-2,3-dicarboximide (PN). The effect of PN addition on the processing characteristics and glass transition temperatures of graphite fiber-reinforced PMR composites is studied. The room temperature and short-time 316 C mechanical properties of the composites are determined. The weight loss and mechanical property retention characteristics of the composites after exposure in air at 316 C are also determined.

  8. Shelf Life of PMR Polyimide Monomer Solutions and Prepregs Extended

    NASA Technical Reports Server (NTRS)

    Alston, William B.; Scheiman, Daniel A.

    2000-01-01

    PMR (Polymerization of Monomeric Reactants) technology was developed in the mid-1970's at the NASA Glenn Research Center at Lewis Field for fabricating high-temperature stable polyimide composites. This technology allowed a solution of polyimide monomers or prepreg (a fiber, such as glass or graphite, impregnated with PMR polyimide monomers) to be thermally cured without the release of volatiles that cause the formation of voids unlike the non-PMR technology used for polyimide condensation type resins. The initial PMR resin introduced as PMR 15 is still commercially available and is used worldwide by aerospace industries as the state-of-the-art resin for high-temperature polyimide composite applications. PMR 15 offers easy composite processing, excellent composite mechanical property retention, a long lifetime at use temperatures of 500 to 550 F, and relatively low cost. Later, second-generation PMR resin versions, such as PMR II 50 and VCAP 75, offer improvements in the upper-use temperature (to 700 F) and in the useful life at temperature without major compromises in processing and property retention but with significant increases in resin cost. Newer versions of nontoxic (non-methylene dianiline) PMR resins, such as BAX PMR 15, offer similar advantages as originally found for PMR 15 but also with significant increases in resin cost. Thus, the current scope of the entire PMR technology available meets a wide range of aeronautical requirements for polymer composite applications.

  9. High molecular weight first generation PMR polyimides for 343 C applications

    NASA Technical Reports Server (NTRS)

    Malarik, Diane C.; Vannucci, Raymond D.

    1991-01-01

    The effect of molecular weight on 343 C thermo-oxidative stability (TOS), mechanical properties, and processability, of the first generation PMR polyimides was studied. Graphite fiber reinforced PMR-15, PMR-30, PMR-50, and PMR-75 composites (corresponding to formulated molecular weights of 1500, 3000, 5000, and 7500, respectively) were fabricated using a simulated autoclave process. The data reveals that while alternate autoclave cure schedules are required for the high molecular weight resins, low void laminates can be fabricated which have significantly improved TOS over PMR-15, with only a small sacrifice in mechanical properties.

  10. High molecular weight first generation PMR polyimides for 343 C applications

    NASA Technical Reports Server (NTRS)

    Malarik, D. C.; Vannucci, R. D.

    1992-01-01

    The effect of molecular weight on 343 C thermo-oxidative stability (TOS), mechanical properties, and processability, of the first generation PMR polyimides was studied. Graphite fiber reinforced PMR-15, PMR-30, PMR-50, and PMR-75 composites (corresponding to formulated molecular weights of 1500, 3000, 5000, and 7500, respectively) were fabricated using a simulated autoclave process. The data reveal that while alternate autoclave cure schedules are required for the high molecular weight resins, low void laminates can be fabricated which have significantly improved TDS over PMR-15, with only a small sacrifice in mechanical properties.

  11. PMR Resin Compositions For High Temperatures

    NASA Technical Reports Server (NTRS)

    Vannucci, Raymond D.

    1989-01-01

    Report describes experiments to identify polymer matrix resins suitable for making graphite-fiber laminates used at 700 degree F (371 degree C) in such applications as aircraft engines to achieve higher thrust-to-weight ratios. Two particular high-molecular-weight formulations of PMR (polymerization of monomer reactants) resins most promising. PMR compositions of higher FMW exhibit enhanced thermo-oxidative stability. Formation of high-quality laminates with these compositions requires use of curing pressures higher than those suitable for compositions of lower FMW.

  12. Review of Transporter-Related Postmarketing Requirement or Postmarketing Commitment Studies.

    PubMed

    Fan, Ying; Sun, Bo; Agarwal, Sheetal; Zhang, Lei

    2016-07-01

    The objectives of this report are to summarize the content and status of transporter-related postmarketing requirement (PMR)/postmarketing commitment (PMC) studies in new drug applications (NDAs) approved by the U.S. Food and Drug Administration (FDA) and to discuss the reasons for requesting such studies and the impact of PMR/PMC study results on labeling to guide the optimal use of the drugs. Multiple data sources were searched to collect information on transporter-related PMR/PMC studies between January 1999 and May 2015. A total of 40 transporter-related PMR/PMC study requests were issued for 35 NDAs. Among these PMR/PMC studies, 27 requested studies related to P-glycoprotein. As of May 31, 2015, 34 transporter-related PMR/PMC studies (85%) are considered "fulfilled" (per the FDA's PMR/PMC website), and 22 (65%) resulted in labeling updates. The majority of the PMR/PMC studies are for drugs in the therapeutic areas of anti-infectives, oncology, and neurology. The results from PMR/PMC studies are important for dosing optimization and are often included in the updated labeling. Because a significant lag time is anticipated between drug approval and PMR/PMC fulfillment, NDA applicants are encouraged to include transporter-related assessments in clinical drug development programs for drug products. PMID:27385175

  13. Characterization of PMR polyimide resin and prepreg

    NASA Technical Reports Server (NTRS)

    Lindenmeyer, P. H.; Sheppard, C. H.

    1984-01-01

    Procedures for the chemical characterization of PMR-15 resin solutions and graphite-reinforced prepregs were developed, and a chemical data base was established. In addition, a basic understanding of PMR-15 resin chemistry was gained; this was translated into effective processing procedures for the production of high quality graphite composites. During the program the PMR monomers and selected model compounds representative of postulated PMR-15 solution chemistry were acquired and characterized. Based on these data, a baseline PMR-15 resin was formulated and evaluated for processing characteristics and composite properties. Commercially available PMR-15 resins were then obtained and chemically characterized. Composite panels were fabricated and evaluated.

  14. Fiber reinforced PMR polyimide composites

    NASA Technical Reports Server (NTRS)

    Cavano, P. J.; Winters, W. E.

    1978-01-01

    Commercially obtained PMR-15 polyimide prepregs with S-glass and graphite fiber reinforcements were evaluated along with in-house prepared glass and graphite cloth PMR 2 materials. A novel autoclave approach was conceived and used to demonstrate that both the PMR systems respond to 1.4 MPa (200 psi) autoclave pressures to produce void free composites equivalent to die molded laminates. Isothermal gravimetric analysis and subsequent mechanical property tests indicated that the PMR 2 system was significantly superior in thermo-oxidative stability, and that S-glass reinforcements may contribute to the accelerated degradation of composites at 316 C (600 F) when compared to graphite fiber reinforced composites. Fully reversed bending fatigue experiments were conducted with a type of fixture unused for organic matrix composites. These studies indicated that the graphite fiber composites were clearly superior in fatigue resistance to the glass fiber reinforced material and that PMR matrix composite systems yield performance of the same order as composite materials employing other families of matrices.

  15. Second generation PMR polyimide/fiber composites

    NASA Technical Reports Server (NTRS)

    Cavano, P. J.

    1979-01-01

    A second generation polymerization monomeric reactants (PMR) polyimdes matrix system (PMR 2) was characterized in both neat resin and composite form with two different graphite fiber reinforcements. Three different formulated molecular weight levels of laboratory prepared PMR 2 were examined, in addition to a purchased experimental fully formulated PMR 2 precurser solution. Isothermal aging of graphite fibers, neat resin samples and composite specimens in air at 316 C were investigated. Humidity exposures at 65 C and 97 percent relative humidity were conducted for both neat resin and composites for eight day periods. Anaerobic char of neat resin and fire testing of composites were conducted with PMR 15, PMR 2, and an epoxy system. Composites were fire tested on a burner rig developed for this program. Results indicate that neat PMR 2 resins exhibit excellent isothermal resistance and that PMR 2 composite properties appear to be influenced by the thermo-oxidative stability of the reinforcing fiber.

  16. Low toxicity high temperature PMR polyimide

    NASA Technical Reports Server (NTRS)

    Pater, Ruth H. (Inventor)

    1992-01-01

    In-situ polymerization of monomer reactants (PMR) type polyimides constitute an important class of ultra high performance composite matrix resins. PMR-15 is the best known and most widely used PMR polyimide. An object of the present invention is to provide a substantially improved high temperature PMR-15 system that exhibits better processability, toughness, and thermo-oxidative stability than PMR-15, as well as having a low toxicity. Another object is to provide new PMR polyimides that are useful as adhesives, moldings, and composite matrices. By the present invention, a new PMR polyimide comprises a mixture of the following compounds: 3,4'-oxydianiline (3,4'-ODA), NE, and BTDE which are then treated with heat. This PMR was designated LaRC-RP46 and has a broader processing window, better reproducibility of high quality composite parts, better elevated temperature mechanical properties, and higher retention of mechanical properties at an elevated temperature, particularly, at 371 C.

  17. Transfer molding of PMR-15 polyimide resin

    NASA Technical Reports Server (NTRS)

    Reardon, J. P.; Moyer, D. W.; Nowak, B. E.

    1985-01-01

    Transfer molding is an economically viable method of producing small shapes of PMR-15 polyimide. It is shown that with regard to flexural, compressive, and tribological properties transfer-molded PMR-15 polyimide is essentially equivalent to PMR-15 polyimide produced by the more common method of compression molding. Minor variations in anisotropy are predictable effects of molding design and secondary finishing operations.

  18. PMR Composites Of Increased Toughness

    NASA Technical Reports Server (NTRS)

    Vannucci, Raymond D.; Bowles, Kenneth J.

    1988-01-01

    Toughness increased without sacrificing processability or hot strength. Resin composition provides best overall balance of composite toughness and retention of mechanical properties at 600 degree F (316 degree C) with processability obtained by substituting 20 mole percent of diamine used in PMR-15 resins with diamine containing twice number of flexible phenyl connecting groups.

  19. Data Crosscutting Requirements Review

    SciTech Connect

    Kleese van Dam, Kerstin; Shoshani, Arie; Plata, Charity

    2013-04-01

    In April 2013, a diverse group of researchers from the U.S. Department of Energy (DOE) scientific community assembled to assess data requirements associated with DOE-sponsored scientific facilities and large-scale experiments. Participants in the review included facilities staff, program managers, and scientific experts from the offices of Basic Energy Sciences, Biological and Environmental Research, High Energy Physics, and Advanced Scientific Computing Research. As part of the meeting, review participants discussed key issues associated with three distinct aspects of the data challenge: 1) processing, 2) management, and 3) analysis. These discussions identified commonalities and differences among the needs of varied scientific communities. They also helped to articulate gaps between current approaches and future needs, as well as the research advances that will be required to close these gaps. Moreover, the review provided a rare opportunity for experts from across the Office of Science to learn about their collective expertise, challenges, and opportunities. The "Data Crosscutting Requirements Review" generated specific findings and recommendations for addressing large-scale data crosscutting requirements.

  20. PMR Graphite Engine Duct Development

    NASA Technical Reports Server (NTRS)

    Stotler, C. L.; Yokel, S. A.

    1989-01-01

    The objective was to demonstrate the cost and weight advantages that could be obtained by utilizing the graphite/PMR15 material system to replace titanium in selected turbofan engine applications. The first component to be selected as a basis for evaluation was the outer bypass duct of the General Electric F404 engine. The operating environment of this duct was defined and then an extensive mechanical and physical property test program was conducted using material made by processing techniques which were also established by this program. Based on these properties, design concepts to fabricate a composite version of the duct were established and two complete ducts fabricated. One of these ducts was proof pressure tested and then run successfully on a factory test engine for over 1900 hours. The second duct was static tested to 210 percent design limit load without failure. An improved design was then developed which utilized integral composite end flanges. A complete duct was fabricated and successfully proof pressure tested. The net results of this effort showed that a composite version of the outer duct would be 14 percent lighter and 30 percent less expensive that the titanium duct. The other type of structure chosen for investigation was the F404 fan stator assembly, including the fan stator vanes. It was concluded that it was feasible to utilize composite materials for this type structure but that the requirements imposed by replacing an existing metal design resulted in an inefficient composite design. It was concluded that if composites were to be effectively used in this type structure, the design must be tailored for composite application from the outset.

  1. PMR polyimide/graphite fiber composite fan blades

    NASA Technical Reports Server (NTRS)

    Cavano, P. J.; Winters, W. E.

    1976-01-01

    Ultrahigh speed fan blades, designed in accordance with the requirements of an ultrahigh tip speed blade axial flow compressor, were fabricated from a high strength graphite fiber tow and a PMR polyimide resin. The PMR matrix was prepared by combining three monomeric reactants in methyl alcohol, and the solution was applied directly to the reinforcing fiber for subsequent in situ polymerization. Some of the molded blades were completely finished by secondary bonding of root pressure pads and an electroformed nickel leading edge sheath prior to final machining. The results of the spin testing of nine PMR fan blades are given. Prior to blade fabrication, heat resin tensile properties of the PMR resin were examined at four formulated molecular weight levels. Additionally, three formulated molecular weight levels were investigated in composite form with both a high modulus and a high strength fiber, both as-molded and postcured, in room temperature and 232 C transverse tensile, flexure and short beam shear. Mixed fiber orientation panels simulating potential blade constructions were also evaluated. Flexure tests, short beam shear tests, and tensile tests were conducted on these angle-plied laminates.

  2. Stability of PMR-polyimide monomer solutions

    NASA Technical Reports Server (NTRS)

    Lauver, R. W.; Alston, W. B.; Vannucci, R. D.

    1979-01-01

    The stability of alcohol solutions of norborneyl capped PMR-polyimide resins was monitored during storage at ambient and subambient temperatures. Chemical changes during storage were determined spectroscopically using nuclear magnetic resonance. Resin processability and cured resin quality were determined by fabrication of unidirectional, graphite fiber composites using aged solutions and testing of selected composite properties. PMR-15 solutions exhibit nominally two weeks of useful life and PMR-2 solutions exhibit nominally two days of useful life at ambient conditions. The limiting factor is precipitation of imide reaction produces from the monomer solutions. Both solutions exhibit substantially longer useful lifetimes in subambient storage. PMR-15 shows no precipitation after several months storage at subambient temperatures. PMR-2 solutions do exhibit precipitates after extended subambient storage, however, the precipitates formed under these conditions can be redissolved. The chemical implications of these observations are discussed.

  3. Titania Deposition on PMR-15

    NASA Technical Reports Server (NTRS)

    Meador, Mary B.; Sutter, James K.; Pizem, Hillel; Gershevitz, Olga; Goffer, Yossi; Frimer, Aryeh A.; Sukenik, Chaim N.; Sampathkumaran, Uma; Milhet, Xavier; McIlwain, Alan

    2005-01-01

    The formation, degree of crystallinity and adherence of dense titania (TiO2) thin film coatings on a high-temperature polyimide resin (PMR-15) can be influenced by the chemical composition of the polymer surface. Furthermore, solution deposition conditions can be adjusted to provide additional control over the morphology and crystallinity of the titania films. Recipes for solution-based titania deposition that used a slowly-hydrolyzing titanium fluoride salt in the presence of boric acid as a fluoride scavenger allowed growth of films up to 750 nm thick in 22 h. By adjusting solution pH and temperature, either amorphous titania or oriented crystalline anatase films could be formed. Surface sulfonate groups enhance the adhesion of solution-deposited oxide thin film coatings. While most sulfonation procedures severely damaged the PMR-15 surface, the use of chlorosulfonic acid followed by hydrolysis of the installed chlorosulfonyl groups provided effective surface sulfonation without significant surface damage. In some cases, the oxide deposition solution caused partial hydrolysis of the polymer surface, which itself was sufficient to allow adhesion of the titania film through chelation of titanium ions by exposed benzoic acid groups on the polymer surface.

  4. Benzonorbornadiene end caps for PMR resins

    NASA Technical Reports Server (NTRS)

    Panigot, Michael J.; Waters, John F.; Varde, Uday; Sutter, James K.; Sukenik, Chaim N.

    1992-01-01

    Several ortho-disubstituted benzonorbornadiene derivatives are described. These molecules contain acid, ester, or anhydride functionality permitting their use as end caps in PMR (polymerization of monomer reactants) polyimide systems. The replacement of the currently used norbornenyl end caps with benzonorbornadienyl end caps affords resins of increased aromatic content. It also allows evaluation of some mechanistic aspects of PMR cross-linking. Initial testing of N-phenylimide model compounds and of actual resin formulations using the benzonorbornadienyl end cap reveals that they undergo efficient thermal crosslinking to give oligomers with physical properties and thermal stability comparable to commercial norbornene-end-capped PMR systems.

  5. Lower-curing-temperature PMR polyimides

    NASA Technical Reports Server (NTRS)

    Serafini, T. T.; Delvigs, P.; Vannucci, R. D.

    1981-01-01

    Studies were performed to achieve a lower-curing-temperature PMR polyimide. The use of m-aminostyrene as the end-cap instead of the monoalkyl ester of 5-normbornene-2,3 dicarboxylic acid was investigated in typical PMR formulations. Model compound studies were also performed. Differential scanning calorimetry studies were performed on model compounds and neat resins to establish their melting and curing characteristics. The elevated temperature weight loss characteristics of neat resins and graphite fiber composites were determined. The room temperature and short-time 260 C (500 F) mechanical properties of the composites were also determined. The use of m-aminostyrene end-caps reduced the final cure temperature of PMR resins by about 55 C (100 F), but the composites prepared with these resins are limited to use temperatures of about 260 C (500 F).

  6. Mutations in PMR5 result in powdery mildew resistance and altered cell wall composition.

    PubMed

    Vogel, John P; Raab, Theodore K; Somerville, Chris R; Somerville, Shauna C

    2004-12-01

    Powdery mildews and other obligate biotrophic pathogens are highly adapted to their hosts and often show limited host ranges. One facet of such host specialization is likely to be penetration of the host cell wall, a major barrier to infection. A mutation in the pmr5 gene rendered Arabidopsis resistant to the powdery mildew species Erysiphe cichoracearum and Erysiphe orontii, but not to the unrelated pathogens Pseudomonas syringae or Peronospora parasitica. PMR5 belongs to a large family of plant-specific genes of unknown function. pmr5-mediated resistance did not require signaling through either the salicylic acid or jasmonic acid/ethylene defense pathways, suggesting resistance in this mutant may be due either to the loss of a susceptibility factor or to the activation of a novel form of defense. Based on Fourier transform infrared analysis, the pmr5 cell walls were enriched in pectin and exhibited a reduced degree of pectin modification relative to wild-type cell walls. In addition, the mutant had smaller cells, suggesting a defect in cell expansion. A double mutant with pmr6 (defective in a glycosylphosphatidylinositol-anchored pectate lyase-like gene) exhibited a strong increase in total uronic acid content and a more severe reduction in size, relative to the single mutants, suggesting that the two genes affect pectin composition, either directly or indirectly, via different mechanisms. These two mutants highlight the importance of the host cell wall in plant-microbe interactions. PMID:15584961

  7. The GlnR Regulon in Streptococcus mutans Is Differentially Regulated by GlnR and PmrA.

    PubMed

    Chen, Yi-Ywan M; Chen, Yueh-Ying; Hung, Jui-Lung; Chen, Pei-Min; Chia, Jean-San

    2016-01-01

    GlnR-mediated repression of the GlnR regulon at acidic pH is required for optimal acid tolerance in Streptococcus mutans, the etiologic agent for dental caries. Unlike most streptococci, the GlnR regulon is also regulated by newly identified PmrA (SMUGS5_RS05810) at the transcriptional level in S. mutans GS5. Results from gel mobility shift assays confirmed that both GlnR and PmrA recognized the putative GlnR box in the promoter regions of the GlnR regulon genes. By using a chemostat culture system, we found that PmrA activated the expression of the GlnR regulon at pH 7, and that this activation was enhanced by excess glucose. Deletion of pmrA (strain ΔPmrA) reduced the survival rate of S. mutans GS5 at pH 3 moderately, whereas the GlnR mutant (strain ΔGlnR) exhibited an acid-sensitive phenotype in the acid killing experiments. Elevated biofilm formation in both ΔGlnR and ΔPmrA mutant strains is likely a result of indirect regulation of the GlnR regulon since GlnR and PmrA regulate the regulon differently. Taken together, it is suggested that activation of the GlnR regulon by PmrA at pH 7 ensures adequate biosynthesis of amino acid precursor, whereas repression by GlnR at acidic pH allows greater ATP generation for acid tolerance. The tight regulation of the GlnR regulon in response to pH provides an advantage for S. mutans to better survive in its primary niche, the oral cavity. PMID:27454482

  8. The GlnR Regulon in Streptococcus mutans Is Differentially Regulated by GlnR and PmrA

    PubMed Central

    Chen, Yi-Ywan M.; Chen, Yueh-Ying; Hung, Jui-Lung; Chen, Pei-Min; Chia, Jean-San

    2016-01-01

    GlnR-mediated repression of the GlnR regulon at acidic pH is required for optimal acid tolerance in Streptococcus mutans, the etiologic agent for dental caries. Unlike most streptococci, the GlnR regulon is also regulated by newly identified PmrA (SMUGS5_RS05810) at the transcriptional level in S. mutans GS5. Results from gel mobility shift assays confirmed that both GlnR and PmrA recognized the putative GlnR box in the promoter regions of the GlnR regulon genes. By using a chemostat culture system, we found that PmrA activated the expression of the GlnR regulon at pH 7, and that this activation was enhanced by excess glucose. Deletion of pmrA (strain ΔPmrA) reduced the survival rate of S. mutans GS5 at pH 3 moderately, whereas the GlnR mutant (strain ΔGlnR) exhibited an acid-sensitive phenotype in the acid killing experiments. Elevated biofilm formation in both ΔGlnR and ΔPmrA mutant strains is likely a result of indirect regulation of the GlnR regulon since GlnR and PmrA regulate the regulon differently. Taken together, it is suggested that activation of the GlnR regulon by PmrA at pH 7 ensures adequate biosynthesis of amino acid precursor, whereas repression by GlnR at acidic pH allows greater ATP generation for acid tolerance. The tight regulation of the GlnR regulon in response to pH provides an advantage for S. mutans to better survive in its primary niche, the oral cavity. PMID:27454482

  9. Improved PMR Polyimides For Heat-Stable Laminates

    NASA Technical Reports Server (NTRS)

    Vannucci, R. D.; Malarik, D. C.; Papadapoulos, D. S.; Waters, John F.

    1994-01-01

    Second-generation PMR-type polyimides (PMR-II polyimides) of enhanced thermo-oxidative stability prepared by substitution of para-aminostyrene (PAS) end caps for nadic-ester (NE) end caps used in prior PMR-II polyimides. Laminates unidirectionally reinforced with graphite fibers and made with PAS-capped resins exhibited thermo-oxidative stabilities significantly greater than those of similar laminates made with NE-capped PMR-II resins. One new laminate exhibited high retention of weight and strength after 1,000 h of exposure to air at 371 degrees C.

  10. 22 CFR 309.10 - Review requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Review requirements. 309.10 Section 309.10 Foreign Relations PEACE CORPS DEBT COLLECTION Collection Actions § 309.10 Review requirements. (a) For purposes of this section, whenever Peace Corps is required to afford a debtor a review within the...

  11. 14 CFR 1274.105 - Review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Review requirements. 1274.105 Section 1274... COMMERCIAL FIRMS General § 1274.105 Review requirements. (a) Once the decision is made by a Headquarters... Procurement Officer. These review requirements also apply where an unsolicited proposal is received from...

  12. Journal clubs. Prevalence, format, and efficacy in PM&R.

    PubMed

    Moberg-Wolff, E A; Kosasih, J B

    1995-01-01

    Journal clubs can play an integral part in graduate medical education. They promote critical thinking, dissemination of information, and research and impact clinical practice. Little has been written, however, about how to organize a journal club or improve its efficacy. Although numerous articles discuss how journal clubs can be used to evaluate medical literature, only a few have examined what physicians are actually doing. We surveyed all accredited PM&R program chief/residents to ascertain the prevalence, format, and efficacy of PM&R residency journal clubs. All programs that responded (89%) reported having a journal club, with most stating its purpose was to disseminate information from the current literature. Review of classic articles and specialty topics (e.g., electromyography, sports medicine) was fairly uncommon. Eighty-four percent of journal clubs were department-sponsored, and most met monthly for 1 hr during the workday. Typically, four or more articles were presented under the guidance of the chief or other resident. Impacting clinical practice and teaching critical analysis were other important goals of the journal clubs, yet most (76%) lacked an organized method for critical review. This, in addition to poor faculty attendance, was a chief concern of those surveyed. Surprisingly, journal club participation was not felt to significantly alter the amount of reading residents did. Although most felt their journal clubs were successful, improving faculty participation, strengthening critical analysis skills, identifying and incorporating classic articles, improving clinical relevance, and providing a mechanism for feedback may further improve journal club efficacy and participant satisfaction. PMID:7779334

  13. Isothermal aging effects on PMR-15 resin

    NASA Technical Reports Server (NTRS)

    Bowles, Kenneth J.; Jayne, Douglas; Leonhardt, Todd A.

    1992-01-01

    Specimens of PMR-15 polyimide neat resin were aged in air at temperatures of 288, 316, and 343 C. Weight losses and dimensional changes were monitored during the course of the exposure time. Physical changes were also observed by optical and electron microscopy. It was found that polyimide polymer degradation occurred within a thin surface layer that developed and grew during thermal aging. The cores of the polymer specimens were protected from oxidative degradation, and they were relatively unchanged by the thermal treatment. Surface cracking was observed at 343 C and was probably due to an interaction between voids and stresses that developed in the surface layer.

  14. Lower-curing-temperature PMR polyimides

    NASA Technical Reports Server (NTRS)

    Delvigs, P.

    1982-01-01

    Partial substitution of a p-aminostyrene end-cap for the monomethyl ester of 5-norbornene-2, 3-dicarboxylic acid lowered the final cure temperature of typical PMR resins from 600 F to 500 F. The weight loss characteristics of neat resins and graphite fiber composites prepared by using the mixed end-cap approach were determined at 600 F. The room temperature and short-time elevated temperature mechanical properties of the composites at 550 F and 600 F were determined. The mechanical property retention characteristics of the composites at 550 F and 600 F are discussed.

  15. Cyclopentadiene evolution during pyrolysis-gas chromatography of PMR polyimides

    NASA Technical Reports Server (NTRS)

    Alston, William B.; Gluyas, Richard E.; Snyder, William J.

    1992-01-01

    The effect of formulated molecular weight (FMW), extent of cure, and cumulative aging on the amount of cyclopentadiene (CPD) evolved from Polymerization of Monomeric Reactants (PMR) polyimides were investigated by pyrolysis-gas chromotography (PY-GC). The PMR polyimides are additional crosslinked resins formed from an aromatic diamine, a diester of an aromatic tetracarboxylic acid and a monoester of 5-norbornene-2, 3-dicarboxylic acid. The PY-GC results were related to the degree of crosslinking and to the thermo-oxidative stability (weight loss) of PMR polyimides. Thus, PY-GC has shown to be a valid technique for the characterization of PMR polyimide resins and composites via correlation of the CPD evolved versus the thermal history of the PMR sample.

  16. A Comparison Study: The New Extended Shelf Life Isopropyl Ester PMR Technology versus The Traditional Methyl Ester PMR Approach

    NASA Technical Reports Server (NTRS)

    Alston, William B.; Scheiman, Daniel A.; Sivko, Gloria S.

    2005-01-01

    Polymerization of Monomeric Reactants (PMR) monomer solutions and carbon cloth prepregs of PMR II-50 and VCAP-75 were prepared using both the traditional limited shelf life methanol based PMR approach and a novel extended shelf life isopropanol based PMR approach. The methyl ester and isopropyl ester based PMR monomer solutions and PMR prepregs were aged for up to four years at freezer and room temperatures. The aging products formed were monitored using high pressure liquid chromatography (HPLC). The composite processing flow characteristics and volatile contents of the aged prepregs were also correlated versus room temperature storage time. Composite processing cycles were developed and six ply cloth laminates were fabricated with prepregs after various extended room temperature storage times. The composites were then evaluated for glass transition temperature (Tg), thermal decomposition temperature (Td), initial flexural strength (FS) and modulus (FM), long term (1000 hours at 316 C) thermal oxidative stability (TOS), and retention of FS and FM after 1000 hours aging at 316 C. The results for each ester system were comparable. Freezer storage was found to prevent the formation of aging products for both ester systems. Room temperature storage of the novel isopropyl ester system increased PMR monomer solution and PMR prepreg shelf life by at least an order of magnitude while maintaining composite properties.

  17. Mechanical Properties of Degraded PMR-15 Resin

    NASA Technical Reports Server (NTRS)

    Tsuji, Luis C.; McManus, Hugh L.; Bowles, Kenneth J.

    1998-01-01

    Thermo-oxidative aging produces a non-uniform degradation state in PMR-15 resin. A surface layer, usually attributed to oxidative degradation, forms. This surface layer has different properties from the inner material. A set of material tests was designed to separate the properties of the oxidized surface layer from the properties of interior material. Test specimens were aged at 316 C in either air or nitrogen, for durations of up to 800 hours. The thickness of the oxidized surface layer in air aged specimens, and the shrinkage and Coefficient of Thermal Expansion (CTE) of nitrogen aged specimens were measured directly. Four-point-bend tests were performed to determine modulus of both the oxidized surface layer and the interior material. Bimaterial strip specimens consisting of oxidized surface material and unoxidized interior material were constructed and used to determine surface layer shrinkage and CTE. Results confirm that the surface layer and core materials have substantially different properties.

  18. PMR polyimide compositions for improved performance at 371 deg C

    NASA Technical Reports Server (NTRS)

    Vannucci, Raymond D.

    1987-01-01

    Studies were conducted to identify matrix resins which have potential for use at 371 C (700 F). Utilizing PMR methodology, neat resin moldings were prepared with various monomer reactants and screened for thermo-oxidative stability at 371 C (700 F) under both ambient and a four-atmosphere air pressure. The results of the resin screening studies indicate that high molecular weight (HMW) formulated resins of first (PMR-15) and second (PMR-II) generation PMR materials exhibit lower levels of weight loss at 371 C (700 F) than PMR-15 and PMR-II resins. The resin systems which exhibited the best overall balance of processability, Tg and thermo-oxidative stability at 371 C were used to prepare unidirectional Celion 6000 and T-40R graphite fiber laminates. Laminates were evaluated for thermo-oxidative stability and 371 C mechanical properties. Results of the laminate evaluation studies indicate that two of the resin compositions have potential for use in 371 C applications. The most promising resin composition provided laminates which exhibited no drop in 371 C mechanical properties and only 11 percent weight loss after 200 hr exposure to 4 atmospheres of air at 371 C.

  19. Mechanical Properties of Degraded PMR-15 Resin

    NASA Technical Reports Server (NTRS)

    Tsuji, Luis C.

    2000-01-01

    Thermo-oxidative aging produces a nonuniform degradation state in PMR-15 resin. A surface layer, usually attributed to oxidative degradation, forms. This surface layer has different properties from the inner material. A set of material tests was designed to separate the properties of the oxidized surface layer from the properties of interior material. Test specimens were aged at 316 C in either air or nitrogen, for durations of up to 800 hr. The thickness of the oxidized surface layer in air aged specimens, and the shrinkage and coefficient of thermal expansion (CTE) of nitrogen aged specimens were measured directly. The nitrogen-aged specimens were assumed to have the same properties as the interior material in the air-aged specimens. Four-point-bend tests were performed to determine modulus of both the oxidized surface layer and the interior material. Bimaterial strip specimens consisting of oxidized surface material and unoxidized interior material were constructed and used to determine surface layer shrinkage and CTE. Results confirm that the surface layer and core materials have substantially different properties.

  20. Quantitative analysis of PMR-15 polyimide resin by HPLC

    NASA Technical Reports Server (NTRS)

    Roberts, Gary D.; Lauver, Richard W.

    1987-01-01

    The concentration of individual components and of total solids of 50 wt pct PMR-15 resin solutions was determined using reverse-phase HPLC to within + or - 8 percent accuracy. Acid impurities, the major source of impurities in 3,3', 4,4'-benzophenonetetracarboxylic acid (BTDE), were eliminated by recrystallizing the BTDE prior to esterification. Triester formation was not a problem because of the high rate of esterification of the anhydride relative to that of the carboxylic acid. Aging of PMR-15 resin solutions resulted in gradual formation of the mononadimide and bisnadimide of 4,4'-methylenedianiline, with the BTDE concentration remaining constant. Similar chemical reactions occurred at a reduced rate in dried films of PMR-15 resin.

  1. Environmental effects on graphite fiber reinforced PMR-15 polyimide

    NASA Technical Reports Server (NTRS)

    Serafini, T. T.; Hanson, M. P.

    1980-01-01

    Studies were conducted to establish the effects of thermo-oxidative and hydrothermal exposure on the mechanical properties of T300 graphite fabric reinforced PMR-15 composites. The effects of hydrothermal exposure on the mechanical properties of HTS-2 continuous graphite fiber composites were also investigated. The thermo-oxidative stability characteristics of T300 fabric and T300 fabric/PMR-15 composites were determined. Flexural strengths of specimens were determined. The useful lifetime of T300 fabric/PMR-15 composites in air at 316 C was found to be about 100 hours. The useful lifetimes in air at 228 and 260 C were determined to be 500 and 1000 hours, respectively. Absorbed moisture was found to reduce the elevated temperature properties of both the T300 fabricate and HTS-2 continuous fiber composites. The moisture effect was found to be reversible.

  2. Environmental effects on graphite fiber reinforced PMR-15 polyimide

    NASA Technical Reports Server (NTRS)

    Serafini, T. T.; Hanson, M. P.

    1982-01-01

    Studies were conducted to establish the effects of thermo-oxidative and hydrothermal exposure on the mechanical properties of T300 graphite fabric reinforced PMR-15 composites. The effects of hydrothermal exposure on the mechanical properties of HTS-2 continuous graphite fiber composites were also investigated. The thermo-oxidative stability characteristics of T300 fabric and T300 fabric/PMR-15 composites were determined. Flexural strengths of specimens were determined. The useful lifetime of T300 fabric/PMR-15 composites in air at 316 C was found to be about 100 hours. The useful lifetimes in air at 228 and 260 C were determined to be 500 and 1000 hours, respectively. Absorbed moisture was found to reduce the elevated temperature properties of both the T300 fabricate and HTS-2 continuous fiber composites. The moisture effect was found to be reversible. Previously announced in STAR as N81-32194

  3. Molecular characterization of the PhoPQ-PmrD-PmrAB mediated pathway regulating polymyxin B resistance in Klebsiella pneumoniae CG43

    PubMed Central

    2010-01-01

    Background The cationic peptide antibiotic polymyxin has recently been reevaluated in the treatment of severe infections caused by gram negative bacteria. Methods In this study, the genetic determinants for capsular polysaccharide level and lipopolysaccharide modification involved in polymyxin B resistance of the opportunistic pathogen Klebsiella pneumoniae were characterized. The expressional control of the genes responsible for the resistance was assessed by a LacZ reporter system. The PmrD connector-mediated regulation for the expression of pmr genes involved in polymyxin B resistance was also demonstrated by DNA EMSA, two-hybrid analysis and in vitro phosphor-transfer assay. Results Deletion of the rcsB, which encoded an activator for the production of capsular polysaccharide, had a minor effect on K. pneumoniae resistance to polymyxin B. On the other hand, deletion of ugd or pmrF gene resulted in a drastic reduction of the resistance. The polymyxin B resistance was shown to be regulated by the two-component response regulators PhoP and PmrA at low magnesium and high iron, respectively. Similar to the control identified in Salmonella, expression of pmrD in K. pneumoniae was dependent on PhoP, the activated PmrD would then bind to PmrA to prolong the phosphorylation state of the PmrA, and eventually turn on the expression of pmr for the resistance to polymyxin B. Conclusions The study reports a role of the capsular polysaccharide level and the pmr genes for K. pneumoniae resistance to polymyxin B. The PmrD connector-mediated pathway in governing the regulation of pmr expression was demonstrated. In comparison to the pmr regulation in Salmonella, PhoP in K. pneumoniae plays a major regulatory role in polymyxin B resistance. PMID:20653976

  4. Quality control developments for graphite/PMR15 polyimide composites materials

    NASA Technical Reports Server (NTRS)

    Sheppard, C. H.; Hoggatt, J. T.

    1979-01-01

    The problem of lot-to-lot and within-lot variability of graphite/PMR-15 prepreg was investigated. The PMR-15 chemical characterization data were evaluated along with the processing conditions controlling the manufacture of PMR-15 resin and monomers. Manufacturing procedures were selected to yield a consistently reproducible graphite prepreg that could be processed into acceptable structural elements.

  5. 41 CFR 109-1.101-50 - DOE-PMR System.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false DOE-PMR System. 109-1.101-50 Section 109-1.101-50 Public Contracts and Property Management Federal Property Management...-Regulation System § 109-1.101-50 DOE-PMR System. The DOE-PMR system described in this subpart is...

  6. 41 CFR 109-1.107-50 - Consultation regarding DOE-PMR.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Consultation regarding DOE-PMR. 109-1.107-50 Section 109-1.107-50 Public Contracts and Property Management Federal Property...-INTRODUCTION 1.1-Regulation System § 109-1.107-50 Consultation regarding DOE-PMR. The DOE-PMR shall be...

  7. 41 CFR 109-1.101-50 - DOE-PMR System.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false DOE-PMR System. 109-1.101-50 Section 109-1.101-50 Public Contracts and Property Management Federal Property Management...-Regulation System § 109-1.101-50 DOE-PMR System. The DOE-PMR system described in this subpart is...

  8. 41 CFR 109-1.107-50 - Consultation regarding DOE-PMR.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Consultation regarding DOE-PMR. 109-1.107-50 Section 109-1.107-50 Public Contracts and Property Management Federal Property...-INTRODUCTION 1.1-Regulation System § 109-1.107-50 Consultation regarding DOE-PMR. The DOE-PMR shall be...

  9. 41 CFR 109-1.101-50 - DOE-PMR System.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false DOE-PMR System. 109-1.101-50 Section 109-1.101-50 Public Contracts and Property Management Federal Property Management...-Regulation System § 109-1.101-50 DOE-PMR System. The DOE-PMR system described in this subpart is...

  10. 41 CFR 109-1.107-50 - Consultation regarding DOE-PMR.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Consultation regarding DOE-PMR. 109-1.107-50 Section 109-1.107-50 Public Contracts and Property Management Federal Property...-INTRODUCTION 1.1-Regulation System § 109-1.107-50 Consultation regarding DOE-PMR. The DOE-PMR shall be...

  11. 41 CFR 109-1.101-50 - DOE-PMR System.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false DOE-PMR System. 109-1.101-50 Section 109-1.101-50 Public Contracts and Property Management Federal Property Management...-Regulation System § 109-1.101-50 DOE-PMR System. The DOE-PMR system described in this subpart is...

  12. 41 CFR 109-1.107-50 - Consultation regarding DOE-PMR.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Consultation regarding DOE-PMR. 109-1.107-50 Section 109-1.107-50 Public Contracts and Property Management Federal Property...-INTRODUCTION 1.1-Regulation System § 109-1.107-50 Consultation regarding DOE-PMR. The DOE-PMR shall be...

  13. 41 CFR 109-1.107-50 - Consultation regarding DOE-PMR.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Consultation regarding DOE-PMR. 109-1.107-50 Section 109-1.107-50 Public Contracts and Property Management Federal Property...-INTRODUCTION 1.1-Regulation System § 109-1.107-50 Consultation regarding DOE-PMR. The DOE-PMR shall be...

  14. 41 CFR 109-1.101-50 - DOE-PMR System.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false DOE-PMR System. 109-1.101-50 Section 109-1.101-50 Public Contracts and Property Management Federal Property Management...-Regulation System § 109-1.101-50 DOE-PMR System. The DOE-PMR system described in this subpart is...

  15. The secretory pathway calcium ATPase PMR-1/SPCA1 has essential roles in cell migration during Caenorhabditis elegans embryonic development.

    PubMed

    Praitis, Vida; Simske, Jeffrey; Kniss, Sarah; Mandt, Rebecca; Imlay, Leah; Feddersen, Charlotte; Miller, Michael B; Mushi, Juliet; Liszewski, Walter; Weinstein, Rachel; Chakravorty, Adityarup; Ha, Dae-Gon; Schacht Farrell, Angela; Sullivan-Wilson, Alexander; Stock, Tyson

    2013-05-01

    Maintaining levels of calcium in the cytosol is important for many cellular events, including cell migration, where localized regions of high calcium are required to regulate cytoskeletal dynamics, contractility, and adhesion. Studies show inositol-trisphosphate receptors (IP3R) and ryanodine receptors (RyR), which release calcium into the cytosol, are important regulators of cell migration. Similarly, proteins that return calcium to secretory stores are likely to be important for cell migration. The secretory protein calcium ATPase (SPCA) is a Golgi-localized protein that transports calcium from the cytosol into secretory stores. SPCA has established roles in protein processing, metal homeostasis, and inositol-trisphosphate signaling. Defects in the human SPCA1/ATP2C1 gene cause Hailey-Hailey disease (MIM# 169600), a genodermatosis characterized by cutaneous blisters and fissures as well as keratinocyte cell adhesion defects. We have determined that PMR-1, the Caenorhabditis elegans ortholog of SPCA1, plays an essential role in embryogenesis. Pmr-1 strains isolated from genetic screens show terminal phenotypes, such as ventral and anterior enclosure failures, body morphogenesis defects, and an unattached pharynx, which are caused by earlier defects during gastrulation. In Pmr-1 embryos, migration rates are significantly reduced for cells moving along the embryo surface, such as ventral neuroblasts, C-derived, and anterior-most blastomeres. Gene interaction experiments show changing the activity of itr-1/IP3R and unc-68/RyR modulates levels of embryonic lethality in Pmr-1 strains, indicating pmr-1 acts with these calcium channels to regulate cell migration. This analysis reveals novel genes involved in C. elegans cell migration, as well as a new role in cell migration for the highly conserved SPCA gene family. PMID:23696750

  16. The Secretory Pathway Calcium ATPase PMR-1/SPCA1 Has Essential Roles in Cell Migration during Caenorhabditis elegans Embryonic Development

    PubMed Central

    Praitis, Vida; Simske, Jeffrey; Kniss, Sarah; Mandt, Rebecca; Imlay, Leah; Feddersen, Charlotte; Miller, Michael B.; Mushi, Juliet; Liszewski, Walter; Weinstein, Rachel; Chakravorty, Adityarup; Ha, Dae-Gon; Schacht Farrell, Angela; Sullivan-Wilson, Alexander; Stock, Tyson

    2013-01-01

    Maintaining levels of calcium in the cytosol is important for many cellular events, including cell migration, where localized regions of high calcium are required to regulate cytoskeletal dynamics, contractility, and adhesion. Studies show inositol-trisphosphate receptors (IP3R) and ryanodine receptors (RyR), which release calcium into the cytosol, are important regulators of cell migration. Similarly, proteins that return calcium to secretory stores are likely to be important for cell migration. The secretory protein calcium ATPase (SPCA) is a Golgi-localized protein that transports calcium from the cytosol into secretory stores. SPCA has established roles in protein processing, metal homeostasis, and inositol-trisphosphate signaling. Defects in the human SPCA1/ATP2C1 gene cause Hailey-Hailey disease (MIM# 169600), a genodermatosis characterized by cutaneous blisters and fissures as well as keratinocyte cell adhesion defects. We have determined that PMR-1, the Caenorhabditis elegans ortholog of SPCA1, plays an essential role in embryogenesis. Pmr-1 strains isolated from genetic screens show terminal phenotypes, such as ventral and anterior enclosure failures, body morphogenesis defects, and an unattached pharynx, which are caused by earlier defects during gastrulation. In Pmr-1 embryos, migration rates are significantly reduced for cells moving along the embryo surface, such as ventral neuroblasts, C-derived, and anterior-most blastomeres. Gene interaction experiments show changing the activity of itr-1/IP3R and unc-68/RyR modulates levels of embryonic lethality in Pmr-1 strains, indicating pmr-1 acts with these calcium channels to regulate cell migration. This analysis reveals novel genes involved in C. elegans cell migration, as well as a new role in cell migration for the highly conserved SPCA gene family. PMID:23696750

  17. Graphite/PMR polyimide composites with improved toughness

    NASA Technical Reports Server (NTRS)

    Vannucci, R. D.; Bowles, K. J.

    1985-01-01

    The toughness of composites made with modified PMR (polymerization of monomer reactants) polyimides and Celion 6000 graphite fibers was studied. Various types/levels of monomer reactants containing flexible links were incorporated into PMR resin compositions used to prepare composites. The composites were evaluated for toughness using instrumented drop weight and 10 deg off axis tensile tests at room temperature, and for strength using flexure and short beam shear tests at room temperature and at elevated temperature. The effect of resin composition on composite processability, thermo-oxidative stability, toughness and mechanical properties are discussed.

  18. Toughening of PMR composites by semi-interpenetrating networks

    NASA Technical Reports Server (NTRS)

    Tiwari, S. N.; Srinivansan, K.

    1991-01-01

    Polymerization of monomer reactants (PMR-15) type polyimide and RP46 prepregs were drum wound using IM-7 fibers. Prepregging and processing conditions were optimized to yield good quality laminates with fiber volume fractions of 60 percent (+/- 2 percent). Samples were fabricated and tested to determine comprehensive engineering properties of both systems. These included 0 deg flexure, short beam shear, transverse flexure and tension, 0 deg tension and compression, intralaminar shear, short block compression, mode 1 and 2 fracture toughness, and compression after impact properties. Semi-2-IPN (interpenetrating polymer networks) toughened PMR-15 and RP46 laminates were also fabricated and tested for the same properties.

  19. Effect of processing parameters on autoclaved PMR polyimide composites

    NASA Technical Reports Server (NTRS)

    Vannucci, R. D.

    1977-01-01

    A study was conducted to determine the effect of processing parameters on the processability and properties of autoclaved fiber reinforced PMR polyimide composites. Composites were fabricated from commercially available graphite fabric and glass fabric PMR polyimide prepreg materials. Process parameters investigated included degree of resin advancement, heating rate, and cure pressure. Composites were inspected for porosity by ultrasonic C scan and photomicrographic examination. Processing characteristics for each set of process parameters and the effect of process parameters on composite mechanical properties at room temperature and 600 F are described.

  20. 14 CFR 1274.105 - Review requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Review requirements. 1274.105 Section 1274... program office or Center procurement personnel, to pursue the Cooperative Agreement Notice (CAN) process... (Code HS). The notification(s) shall be forwarded by the cognizant Headquarters program office or...

  1. Application of Gr/PMR-15 to commercial aircraft

    NASA Technical Reports Server (NTRS)

    Postlewaite, J.; Porter, K.; Mclaren, D.

    1985-01-01

    Following from early experience with polyimides on the SST program and Shuttle aft flap studies the Boeing Company is now working on collaborative programs with its principal nacelle suppliers to pursue the development of Gr/PMR-15 nacelle components. Two programs are currently in effect. The first program is directed specifically towards the flight test and service evaluation at the earliest possible date of a 747 nacelle core cowl structure. The second program seeks to firmly establish the producibility and cost of a 757 thrust reverser C duct in a production environment. The near term objectives of these programs include: (1) the comparison of estimated cost and weight of Gr/PMR-15 versus metal structure, (2) the engine test of representative composite structure, (3) the preliminary design and analysis of the C duct structure, and (4) the preparation of cost data and time schedules for the development and producibility program. In addition to powerplant structure, the propulsion ducting system has shown to be a strong candidate for Gr/PMR-15 application. Currently, the Boeing 747 Organization is evaluating the use of PMR-15 matrix composites to replace nearly 800 lbs of titanium ducting per airplane.

  2. FDEMS Sensing for Automated Intelligent Processing of PMR-15

    NASA Technical Reports Server (NTRS)

    Kranbuehl, David E.; Hood, D. K.; Rogozinski, J.; Barksdale, R.; Loos, Alfred C.; McRae, Doug

    1993-01-01

    The purpose of this grant was to develop frequency dependent dielectric measurements, often called FDEMS (frequency dependent electromagnetic sensing), to monitor and intelligently control the cure process in PMR-15, a stoichiometric mixture of a nadic ester, dimethyl ester, and methylendianiline in a monomor ratio.

  3. Dynamic Mechanical Properties of N-Phenylnadimide Modified PMR Polyimide Composites

    NASA Technical Reports Server (NTRS)

    Pater, R. H.

    1983-01-01

    The rheological behavior of newly developd Celion 6000/N-phenylnadimide modified PMR polyimide and PMR-15 composites was investigated. The dynamic mechanical properties were correlated with the structure of N-phenylnadimide modified PMR polyimides. The storage modulus (G'), loss modulus (G''), and loss tangent (tan delta) of four composite systems were measured over a temperature range from -150 to 400 C. Three well defined peaks were seen in the regions of 360, 100, and -120 C, corresponding to the alpha, beta, and gamma relaxations, respectively, of the matrix resins. The activation energies of the alpha, beta, and gamma relaxations were estimated to be 232, 60, and 14 kcal/mole, respectively, for PMR-15. Addition of N-phenylnadimide to the PMR-15 composition lowered the glass transition temperature and the activation energies of PMR-15 polyimide. The dynamic mechanical data appear to be consistent with the formation of a copolymer from N-phenylnadimide and a PMR-15 prepolymer.

  4. Review of FEWS NET Biophysical Monitoring Requirements

    NASA Technical Reports Server (NTRS)

    Ross, K. W.; Brown, Molly E.; Verdin, J.; Underwood, L. W.

    2009-01-01

    The Famine Early Warning System Network (FEWS NET) provides monitoring and early warning support to decision makers responsible for responding to famine and food insecurity. FEWS NET transforms satellite remote sensing data into rainfall and vegetation information that can be used by these decision makers. The National Aeronautics and Space Administration has recently funded activities to enhance remote sensing inputs to FEWS NET. To elicit Earth observation requirements, a professional review questionnaire was disseminated to FEWS NET expert end-users: it focused upon operational requirements to determine additional useful remote sensing data and; subsequently, beneficial FEWS NET biophysical supplementary inputs. The review was completed by over 40 experts from around the world, enabling a robust set of professional perspectives to be gathered and analyzed rapidly. Reviewers were asked to evaluate the relative importance of environmental variables and spatio-temporal requirements for Earth science data products, in particular for rainfall and vegetation products. The results showed that spatio-temporal resolution requirements are complex and need to vary according to place, time, and hazard: that high resolution remote sensing products continue to be in demand, and that rainfall and vegetation products were valued as data that provide actionable food security information.

  5. ESCRT components regulate the expression of the ER/Golgi calcium pump gene PMR1 through the Rim101/Nrg1 pathway in budding yeast.

    PubMed

    Zhao, Yunying; Du, Jingcai; Xiong, Bing; Xu, Huihui; Jiang, Linghuo

    2013-10-01

    The endosomal sorting complex required for transport (ESCRT) complexes function to form multivesicular bodies for sorting of proteins destined for the yeast vacuole or the mammalian lysosome. ESCRT components are well conserved in eukaryotes, and their mutations cause neurodegenerative diseases and other cellular pathologies in humans. PMR1 is the orthologous gene of two human genes for calcium pumps secretory pathway Ca(2+)-ATPase (SPCA1, ATP2C1) and sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA, ATP2A2), which are mutated in Hailey-Hailey and Darier genetic diseases, respectively. Here we show that deletion mutation of ESCRT components Snf7, Snf8, Stp22, Vps20, Vps25, Vps28, or Vps36 activates the calcium/calcineurin signaling in yeast cells, but surprisingly leads to a nearly 50% reduction in expression of the ER/Golgi calcium pump gene PMR1 independent of calcium stress. These ESCRT mutants are known to have a defect in Rim101 activation. Ectopic expression of a constitutively active form of Rim101 or further deletion of NRG1 in these mutants partially suppresses their calcium hypersensitivity. Deletion of NRG1 also completely rescues the expression of PMR1 in these mutants to the level of the wild type. Promoter mutagenesis, gel electrophoretic mobility shift assay, and chromatin immunoprecipitation analysis demonstrate that Nrg1 binds to two motifs in the PMR1 promoter. In addition, expression of PMR1 under the control of its promoters with mutated Nrg1-binding motifs suppresses the calcium hypersensitivity of these ESCRT mutants. Collectively, these data have uncovered a function of ESCRT components in regulating PMR1 expression through the Nrg1/Rim101 pathway. Our findings provide important clues for understanding human diseases related to calcium homeostasis. PMID:23933635

  6. Transverse microcracking in Celion 6000/PMR-15 graphite-polyimide

    NASA Technical Reports Server (NTRS)

    Mills, J. S.; Herakovich, C. T.; Davis, J. G., Jr.

    1979-01-01

    The effects of room temperature tensile loading and five thermal loadings, in the range -320 F (-196C) to 625F (330CC), upon the development of transverse microcracks (TVM) in Celion 6000/PMR-15 graphite-polyimide laminates were investigated. Microcracks were observed using a replicating technique, microscopy and X-ray. The mechanical or thermal load at which microcracking initiates and the ply residual stresses were predicted using laminate analysis with stress- and temperature-dependent material properties.

  7. Properties of PMR Polyimide composites made with improved high strength graphite fibers

    NASA Technical Reports Server (NTRS)

    Vannucci, R. D.

    1980-01-01

    High strength, intermediate modulus graphite fibers were obtained from various commercial suppliers, and were used to fabricate PMR-15 and PMR-2 polyimide composites. The effects of the improved high strength graphite fibers on composite properties after exposure in air at 600 F were investigated. Two of the improved fibers were found to have an adverse effect on the long term performance of PMR composites. The influence of various factors such as fiber physical properties, surface morphology and chemical composition were also examined.

  8. Effects of graphite fiber stability on the properties of PMR polyimide composites

    NASA Technical Reports Server (NTRS)

    Delvigs, P.; Alston, W. B.; Vannucci, R. D.

    1979-01-01

    The effect of the stability of graphite fibers on composite properties after exposure in air at 600 F was investigated. Composites were fabricated from PMR-15 and PMR-2 monomer solutions, using HTS-2 and Celion 6000 graphite fibers as the reinforcement. The effect of long-term exposure in air at 600 F on composite weight loss and mechanical properties was determined. These composites exhibited a significantly increased lifetime at that temperature compared to composites fabricated from HTS fiber sold prior to 1975. The effect of the PMR-15 and PMR-II resin compositions on long-term composite performance at 600 F is also discussed.

  9. Thermo-oxidative stability studies of Celion 6000/PMR-15 unidirectional composites, PMR-15, and Celion 6000 fiber

    NASA Technical Reports Server (NTRS)

    Bowles, Kenneth J.; Nowak, Gregory

    1988-01-01

    Experimental results on the influence of the thermooxidative resistance characteristics of the fiber and matrix resin on the thermal stability of isothermally aged Celion 6000/PMR-15 matrix resin composites are presented. SEM studies reveal that extreme oxidative erosion of the graphite fiber occurs at elevated temperatures in the presence of the polyimide matrix. The activation energy of oxidation of the composite was shown to be greater than those of the fiber and the matrix resin.

  10. 77 FR 59447 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-27

    ... From the Federal Register Online via the Government Publishing Office ] SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of Reporting Requirements Submitted for OMB Review. SUMMARY: Under the provisions of...

  11. 78 FR 5555 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of Reporting Requirements Submitted for OMB Review. SUMMARY: Under the provisions of...

  12. 77 FR 12902 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of Reporting Requirements Submitted for OMB Review. SUMMARY: Under the provisions of...

  13. 76 FR 8393 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of reporting requirements submitted for OMB review. SUMMARY: Under the provisions of...

  14. 78 FR 21002 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of 30 day Reporting Requirements Submitted for OMB Review. SUMMARY: Under the...

  15. 78 FR 18663 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-27

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of 30 day Reporting Requirements Submitted for OMB Review. SUMMARY: Under the...

  16. 76 FR 70527 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of Reporting Requirements Submitted for OMB Review. SUMMARY: Under the provisions of the... of Respondents: Programs Application and participants, SSBIC receiving grants under the NMVC...

  17. 78 FR 11263 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of reporting requirements submitted for OMB review. SUMMARY: Under the provisions of...

  18. 78 FR 74216 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-10

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ] ACTION: Notice of 30 day Reporting Requirements Submitted for OMB Review. SUMMARY: Under the...

  19. 78 FR 77194 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of 30 day reporting requirements submitted for OMB review. SUMMARY: Under the...

  20. 76 FR 14114 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-15

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of reporting requirements submitted for OMB review. SUMMARY: Under the provisions of...

  1. 77 FR 8942 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of Reporting Requirements Submitted for OMB Review. SUMMARY: Under the provisions of...

  2. 76 FR 72019 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of Reporting Requirements Submitted for OMB Review. SUMMARY: Under the provisions of...

  3. 76 FR 61129 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of Reporting Requirements Submitted for OMB Review. SUMMARY: Under the provisions of...

  4. 76 FR 18821 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration. ACTION: Notice of reporting requirements submitted for OMB review. SUMMARY: Under the provisions of...

  5. 14 CFR § 1274.105 - Review requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Review requirements. § 1274.105 Section Â... WITH COMMERCIAL FIRMS General § 1274.105 Review requirements. (a) Once the decision is made by a... Procurement Officer. These review requirements also apply where an unsolicited proposal is received from...

  6. 48 CFR 849.111-70 - Required review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Required review. 849.111... MANAGEMENT TERMINATION OF CONTRACTS General Principles 849.111-70 Required review. (a) FAR 49.111 requires each agency to establish procedures, when necessary, for the administrative review of...

  7. 42 CFR 476.71 - QIO review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS UTILIZATION AND QUALITY CONTROL REVIEW Review Responsibilities of Utilization and Quality Control Quality Improvement Organizations (QIOs) General Provisions § 476.71 QIO review requirements. (a) Scope of QIO review. In its review, the QIO must determine...

  8. Solution structure and tandem DNA recognition of the C-terminal effector domain of PmrA from Klebsiella pneumoniae

    PubMed Central

    Lou, Yuan-Chao; Wang, Iren; Rajasekaran, M.; Kao, Yi-Fen; Ho, Meng-Ru; Hsu, Shang-Te Danny; Chou, Shan-Ho; Wu, Shih-Hsiung; Chen, Chinpan

    2014-01-01

    Klebsiella pneumoniae PmrA is a polymyxin-resistance-associated response regulator. The C-terminal effector/DNA-binding domain of PmrA (PmrAC) recognizes tandem imperfect repeat sequences on the promoters of genes to induce antimicrobial peptide resistance after phosphorylation and dimerization of its N-terminal receiver domain (PmrAN). However, structural information concerning how phosphorylation of the response regulator enhances DNA recognition remains elusive. To gain insights, we determined the nuclear magnetic resonance solution structure of PmrAC and characterized the interactions between PmrAC or BeF3−-activated full-length PmrA (PmrAF) and two DNA sequences from the pbgP promoter of K. pneumoniae. We showed that PmrAC binds to the PmrA box, which was verified to contain two half-sites, 5′-CTTAAT-3′ and 5′-CCTAAG-3′, in a head-to-tail fashion with much stronger affinity to the first than the second site without cooperativity. The structural basis for the PmrAC–DNA complex was investigated using HADDOCK docking and confirmed by paramagnetic relaxation enhancement. Unlike PmrAC, PmrAF recognizes the two sites simultaneously and specifically. In the PmrAF–DNA complex, PmrAN may maintain an activated homodimeric conformation analogous to that in the free form and the interactions between two PmrAC molecules aid in bending and binding of the DNA duplex for transcription activation. PMID:24371275

  9. Management of government property in the possession of off-site contractors (DOE-PMR 109-60)

    SciTech Connect

    1980-01-01

    This handbook contains Part 109-60 of the DOE Property Management Regulations (DOE-PMR) (41 CFR Chapter 109). This Part 109-60 sets forth the minimum requirements to be observed by off-site contractors in establishing and maintaining control over Government property provided pursuant to a contract with DOE. The contract clauses of the DOE Procurement Regulations incorporate Part 109-60 by reference in all off-site contracts in which Government property is provided. Individual Subparts of this Part deal with contractor's responsibility; records and financial reports; identification; physical inventories; care and maintenance; utilization, disposal, and retirement; motor vehicle and aircraft management; and required reports. (RWR)

  10. PMR polyimides - Processable high temperature composite matrix resins

    NASA Technical Reports Server (NTRS)

    Winters, W. E.; Serafini, T. T.

    1975-01-01

    Processing reproducibility and versatility were demonstrated for producing addition-cured polyimide/graphite fiber composites using a unique in situ polymerization of monomeric reactants directly on the fiber surface. The polymers so derived, designated PMR polyimides, can be fabricated into composite structures by laminating, random fiber molding or autoclave curing. Composites were determined to be thermally stable and retain useful properties after extended exposures at 550 to 650 F. The material and fabrication capability were demonstrated by the fabrication and evaluation of prototype complex fan blades.-

  11. PMR polyimides: Processable high temperature composite matrix resins

    NASA Technical Reports Server (NTRS)

    Winters, W. E.; Serafini, T. T.

    1975-01-01

    Processing reproducibility and versatility were demonstrated for producing addition-cured polyimide/graphite fiber composites using an in situ polymerization of monomeric reactants directly on the fiber surface. The polymers so derived, designated PMR polyimides, can be fabricated into composite structures by laminating, random fiber molding or autoclave curing. Composites were determined to be thermally stable and retain useful properties after extended exposures at 550 F to 650 F. The material and fabrication capability were demonstrated by the fabrication and evaluation of prototype complex fan blades.

  12. FTIR characterization of thermally cycled PMR-15 composites

    NASA Technical Reports Server (NTRS)

    Young, Philip R.; Chang, A. C.

    1988-01-01

    Chemical characterization results are presented for a variety of PMR-15/graphite composites, differentiated according to prepreg types and cure cycles, which were subjected to 1000 thermal cycles between 0 and 450 F. Fourier transform IR spectroscopy was used in conjunction with diffuse reflectance sampling to examine whether changes in the matrix resin chemistry due to environmental exposure may have contributed to microcracking. Analysis based on compound spectra revealed behavior associated with the oxidation of methylene groups to carbonyl groups on the composite surface; evidence of crosslinking also emerged, although the two phenomena do not appear to be related.

  13. Effect of ester impurities in PMR-polyimide resin

    NASA Technical Reports Server (NTRS)

    Lauver, R. W.

    1976-01-01

    Spectral and chomatographic studies were conducted which established the presence of tri- and tetraester impurities in aged monomer solutions employed in fabrication of PMR-polyimide resin composites. The equilibrium constant and apparent rate of the esterification were determined. It was demonstrated, using differential scanning calorimetry, that the ortho-ester moiety of these impurities does not completely react at typical cure conditions. It is concluded that voids formed in composites fabricated with aged monomer solution are due to gaseous decomposition products evolved by ester impurities and/or unreacted amine during elevated temperature post-cure treatment.

  14. Properties of autoclaved Gr/PI composites made from improved tack PMR-15 prepreg

    NASA Technical Reports Server (NTRS)

    Vannucci, R. D.

    1985-01-01

    Autoclave processing studies were conducted, using improved tack PMR-15 prepreg, to determine the effect of tack enhancing PMR resin modifications on composite processability and mechanical properties. Improved tack graphite fiber reinforced PMR-15 prepregs were prepared and exposed to ambient conditions for various times and then autoclave molded into composites. Composite specimens were prepared and tested for flexural and interlaminar shear strengths at room temperature and 316 C. The retention of flexural and interlaminar shear strength as a function of exposure in air at 316 C was also determined. The results show that the modified PMR resin solutions provide prepreg with improved tack and drape retention characteristics without adversely affecting processability or mechanical properties of autoclave molded graphite fiber reinforced PMR-15 composites.

  15. Analyzing pmrA and pmrB genes in Acinetobacter baumannii resistant to colistin in Shahid Rajai Shiraz, Iran Hospital by PCR: First report in Iran.

    PubMed

    Sepahvand, Shahriar; Doudi, Monir; Davarpanah, Mohammad Ali; Bahador, Abbas; Ahmadi, Mehranoosh

    2016-07-01

    Acinetobacter baumanni is known as a worldwide emerging nosocomial infections and it is classified as one of the six dangerous microorganisms by Diseases Society of America. Multi drug-resistant strains of A. baumannii have been reported in recent decades, which may be a result of the high use of antimicrobial agents. Colistin is the last form of treatment against this organism. The presence of pmrA and pmrB genes in A. baumannii causes the resistance of this organism against Colistin. This cross-sectional study was performed on 100 samples of A. baumannii isolated from ulcer, urinary, respiratory, blood of patients admitted to the intensive care unit of Shahid Rajai Shiraz hospital within a 12-month period. The diagnosis was performed by microscopic and biochemical testing using microgen kits. Determining Colistin resistance was carried out by Diffusion Disc, Colistin antibiotic disc of MAST- England and E-test. The analysis of genes pmrA and pmrB genes was done by PCR. 100 A. baumannii samples were diagnosed out of which using diffusion disk 94 cases were sensitive to Colistin and 6 cases were resistant to it. The E-test results in resistant samples presented an MIC equal to 64 micrograms per milliliter. The PCR results in sensitive and resistant to Colistin samples presented the existence of pmrA and pmrB genes. The results indicated the presence of pmrA and pmrB genes that are the main reason of A. baumannii resistance against the last line of treatment of this organism to Colistin. PMID:27592491

  16. 40 CFR 63.5 - Preconstruction review and notification requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 9 2011-07-01 2011-07-01 false Preconstruction review and notification... Provisions § 63.5 Preconstruction review and notification requirements. (a) Applicability. (1) This section implements the preconstruction review requirements of section 112(i)(1). After the effective date of...

  17. 40 CFR 63.5 - Preconstruction review and notification requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 10 2013-07-01 2013-07-01 false Preconstruction review and... CATEGORIES General Provisions § 63.5 Preconstruction review and notification requirements. (a) Applicability. (1) This section implements the preconstruction review requirements of section 112(i)(1). After...

  18. 40 CFR 63.5 - Preconstruction review and notification requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 10 2012-07-01 2012-07-01 false Preconstruction review and... CATEGORIES General Provisions § 63.5 Preconstruction review and notification requirements. (a) Applicability. (1) This section implements the preconstruction review requirements of section 112(i)(1). After...

  19. 40 CFR 63.5 - Preconstruction review and notification requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 10 2014-07-01 2014-07-01 false Preconstruction review and... CATEGORIES General Provisions § 63.5 Preconstruction review and notification requirements. (a) Applicability. (1) This section implements the preconstruction review requirements of section 112(i)(1). After...

  20. 42 CFR 412.508 - Medical review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Medical review requirements. 412.508 Section 412... Long-Term Care Hospitals § 412.508 Medical review requirements. (a) Admission and quality review. A..., the following: (1) The medical necessity, reasonableness, and appropriateness of hospital...

  1. 42 CFR 412.508 - Medical review requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Medical review requirements. 412.508 Section 412... Long-Term Care Hospitals § 412.508 Medical review requirements. (a) Admission and quality review. A..., the following: (1) The medical necessity, reasonableness, and appropriateness of hospital...

  2. 42 CFR 412.508 - Medical review requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Medical review requirements. 412.508 Section 412... Long-Term Care Hospitals § 412.508 Medical review requirements. (a) Admission and quality review. A..., the following: (1) The medical necessity, reasonableness, and appropriateness of hospital...

  3. 42 CFR 412.508 - Medical review requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... medical or other practices with respect to beneficiaries or billing for services furnished to... 42 Public Health 2 2011-10-01 2011-10-01 false Medical review requirements. 412.508 Section 412... Long-Term Care Hospitals § 412.508 Medical review requirements. (a) Admission and quality review....

  4. Design Allowables Test Program, Celion 3000/PMR-15 and Celion 6000/PMR-15, Graphite/Polyimide Composites

    NASA Technical Reports Server (NTRS)

    Cushman, J. B.; Mccleskey, S. F.

    1982-01-01

    A design allowables test program was conducted on Celion 3000/PRM-15 and Celion 6000/PMR-15 graphite/polyimide composite to establish material performance over a 116 K (-250 F) to 589 K (600 F) temperature range. Effects of aging, thermal cycling and moisture were also evaluated. Tension, compression and in plane shear properties were determined for uniaxial, pseudoisotropic and +45 laminates. Test results show sufficient strength and stiffness to substantiate graphite/polyimide composites as an acceptable structural material for high temperature structural applications.

  5. An investigation into the injection molding of PMR-15 polyimide

    NASA Technical Reports Server (NTRS)

    Colaluca, M. A.

    1984-01-01

    The chemorheological behavior of the PRM-15 molding compounds were characterized, the range of suitable processing parameters for injection molding in a reciprocating screw injection molding machine was determined, and the effects of the injection molding processing parameters on the mechanical properties of molded PMR-15 parts were studied. The apparatus and procedures for measuring viscosity and for determining the physical response of the material during heating are described. Results show that capillary rheometry can be effectively used with thermosets if the equipment is designed to overcome some of the inherent problems of these materials. A uniform temperature was provided in the barrel by using a circulating hot oil system. Standard capillary rheometry methods can provide the dependence of thermoset apparent viscosity on shear rate, temperature, and time. Process conditions resulting in complete imidization should be carefully defined. Specification of controlled oven temperature is inadequate and can result in incomplete imidization. For completely imidized PMR-15 heat at 15 C/min melt flow without gas evolution occurs in the temperature range of 325 C to 400 C.

  6. The 700 F properties of autoclave cured PMR-2 composites

    NASA Technical Reports Server (NTRS)

    Vannucci, Raymond D.; Cifani, Diane

    1988-01-01

    Studies were conducted to develop autoclave processing parameters for graphite reinforced PMR-2 resin composite materials intended for use in applications at temperatures up to 371 degrees (700 F). The effect of resin composition on autoclaveability was investigated. The effect of various graphite fibers and resin composition on 343 C (650 F) and 371 C (700 F) thermo-oxidative stability and mechanical properties was also investigated. The results of the processing studies show that PMR-2 resin composites can be easily fabricated under autoclave conditions. Autoclaved laminates exposed to 1 atm of air at 343 C (650 F) and 371 C (700 F) exhibited less than 5 percent weight loss after 750 hr exposure to 650 F air and 8 percent weight loss during exposure to 700 F air for 500 hr. After 500 hr exposure, autoclaved laminates exhibited greater than 90 percent retention of initial 650 and 700 F flexural and interlaminar shear strengths. The effect of resin formulated molecular weight and postcure conditions on laminate glass transition temperature is also discussed.

  7. 700 F properties of autoclave cured PMR-II composites

    NASA Technical Reports Server (NTRS)

    Cifani, Diane

    1988-01-01

    Studies were conducted to develop autoclave processing parameters for graphite reinforced PMR-2 resin composite materials intended for use in applications at temperatures up to 371 degrees (700 F). The effect of resin composition on autoclaveability was investigated. The effect of various graphite fibers and resin composition on 343 C (650 F) and 371 C (700 F) thermo-oxidative stability and mechanical properties was also investigated. The results of the processing studies show that PMR-2 resin composites can be easily fabricated under autoclave conditions. Autoclaved laminates exposed to 1 atm of air at 343 C (650 F) and 371 C (700 F) exhibited less than 5 percent weight loss after 750 hr exposure to 650 F air and 8 percent weight loss during exposure to 700 F air for 500 hr. After 500 hr exposure, autoclaved laminates exhibited greater than 90 percent retention of initial 650 and 700 F flexural and interlaminar shear strengths. The effect of resin formulated molecular weight and postcure conditions on laminate glass transition temperature is also discussed.

  8. Thermal stability relationships between PMR-15 resin and its composites

    SciTech Connect

    Bowles, K.J.; Jayne, D.; Leonhardt, T.A.; Bors, D.

    1993-10-01

    A study was conducted to investigate the relationship between the thermo-oxidative stability of PMR-15 matrix resin and the stability of graphite-fiber-reinforced composites that contain this resin as the matrix material. Three areas were investigated. The first was the effect of fiber/matrix interfacial bond strength on the isothermal aging weight loss of composites. By using type-A graphite fibers produced by Hercules, it was possible to study composites reinforced with fibers that were processed to receive different surface treatments. One of the fibers was untreated, a second fiber was treated by oxidation to enhance fiber/matrix bonding, and the third type of fiber was coated with an epoxy sizing. These treatments produced three significantly different interfacial bond strengths. The epoxy sizing on the third fiber was quickly oxidized from the bare fiber surfaces at 288, 316, and 343 C. The weight loss due to the removal of the sizing was constant at 1.5 percent. This initial weight loss was not observed in thermo-oxidative stability studies of composites. The PMR-15 matrix satisfactorily protected the reinforcemnt at all three temperatures.

  9. Thermal stability relationships between PMR-15 resin and its composites

    NASA Technical Reports Server (NTRS)

    Bowles, Kenneth J.; Jayne, Douglas; Leonhardt, Todd A.; Bors, Dennis

    1993-01-01

    A study was conducted to investigate the relationship between the thermo-oxidative stability of PMR-15 matrix resin and the stability of graphite-fiber-reinforced composites that contain this resin as the matrix material. Three areas were investigated. The first was the effect of fiber/matrix interfacial bond strength on the isothermal aging weight loss of composites. By using type-A graphite fibers produced by Hercules, it was possible to study composites reinforced with fibers that were processed to receive different surface treatments. One of the fibers was untreated, a second fiber was treated by oxidation to enhance fiber/matrix bonding, and the third type of fiber was coated with an epoxy sizing. These treatments produced three significantly different interfacial bond strengths. The epoxy sizing on the third fiber was quickly oxidized from the bare fiber surfaces at 288, 316, and 343 C. The weight loss due to the removal of the sizing was constant at 1.5 percent. This initial weight loss was not observed in thermo-oxidative stability studies of composites. The PMR-15 matrix satisfactorily protected the reinforcemnt at all three temperatures.

  10. 42 CFR 412.46 - Medical review requirements: Physician acknowledgement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PROSPECTIVE PAYMENT SYSTEMS FOR INPATIENT HOSPITAL SERVICES... Capital-Related Costs § 412.46 Medical review requirements: Physician acknowledgement. (a) Basis....

  11. Feasibility of Kevlar 49/PMR-15 polyimide for high temperature applications

    NASA Technical Reports Server (NTRS)

    Hanson, M. P.

    1980-01-01

    Kevlar 49 aramid organic fiber reinforced PMR-15 polyimide laminates were characterized to determine the applicability of the material to high temperature aerospace structures. Kevlar 49/3501-6 epoxy laminates were fabricated and characterized for comparison with the Kevlar 49/PMR-15 polyimide material. Flexural strengths and moduli and interlaminar shear strengths were determined from 75 to 600 F for the PMR-15 and from 75 to 450 F for the Kevlar 49/3501-6 epoxy material. The study also included the effects of hydrothermal and long-term elevated temperature exposures on the flexural strengths and moduli and the interlaminar shear strengths.

  12. Feasibility of Kevlar 49/PMR-15 Polyimide for High Temperature Applications

    NASA Technical Reports Server (NTRS)

    Hanson, M. P.

    1980-01-01

    Kevlar 49 aramid organic fiber reinforced PMR-15 polyimide laminates were characterized to determine the applicability of the material to high temperature aerospace structures. Kevlar 49/3501-6 epoxy laminates were fabricated and characterized for comparison with the Kevlar 49/PMR-15 polyimide material. Flexural strengths and moduli and interlaminar shear strengths were determined from 75 F to 600 F for the PMR-15 and from 75 F to 450 F for the Kevlar/3501-6 epoxy material. The effects of hydrothermal and long-term elevated temperature exposures on the flexural strengths and moduli and the interlaminar shear strengths were also studied.

  13. PMR-15/Layered Silicate Nanocomposites For Improved Thermal Stability And Mechanical Properties

    NASA Technical Reports Server (NTRS)

    Campbell, Sandi; Scheiman, Daniel; Faile, Michael; Papadopoulos, Demetrios; Gray, Hugh R. (Technical Monitor)

    2002-01-01

    Montmorillonite clay was organically modified by co-exchange of an aromatic diamine and a primary alkyl amine. The clay was dispersed into a PMR (Polymerization of Monomer Reactants)-15 matrix and the glass transition temperature and thermal oxidative stability of the resulting nanocomposites were evaluated. PMR-15/ silicate nanocomposites were also investigated as a matrix material for carbon fabric reinforced composites. Dispersion of the organically modified silicate into the PMR-15 matrix enhanced the thermal oxidative stability, the flexural strength, flexural modulus, and interlaminar shear strength of the polymer matrix composite.

  14. DMBZ Polyimides Provide an Alternative to PMR-15 for High-Temperature Applications

    NASA Technical Reports Server (NTRS)

    2005-01-01

    PMR-15, a high-temperature polyimide developed in the mid-1970's at the NASA Lewis Research Center, offers the combination of ease of processing, low cost, and good stability and performance at temperatures up to 288 C (500 F). This material is widely regarded as one of the leading high-temperature matrix resins for polymer-matrix-composite aircraft engine components. PMR-15 is widely used in both military and civilian aircraft engines. The current worldwide market for PMR-15 is on the order of 50,000 lb, with a total sales of around $5 to $10 million. However, PMR-15 is made from methylene dianiline (MDA), a known animal mutagen and a suspected human mutagen. Recent concerns about the safety of workers involved in the manufacture and repair of PMR-15 components have led to the implementation of costly protective measures to limit worker exposure and ensure workplace safety. In some cases, because of safety and economic concerns, airlines have eliminated PMR-15 components from engines in their fleets. Current efforts at Lewis are focused on developing suitable replacements for PMR-15 that do not contain mutagenic constituents and have processability, stability, and mechanical properties comparable to that of PMR-15. A recent development from these efforts is a new class of thermosetting polyimides based on 2,2'-dimethylbenzidine (DMBZ). Autoclave processing developed for PMR-15 composites was used to prepare low-void-content T650-35 carbon-fiber-reinforced laminates from DMBZ-15 polyimides. The glass transition temperatures of these laminates were about 50 C higher than those of the T650- 35/PMR-15 composites (400 versus 348 C). In addition, DMBZ-15 polyimide composites aged for 1000 hr in air at 288 C (500 F) had weight losses close to those of comparable PMR-15 laminates (0.9 versus 0.7 percent). The elevated (288 C) and room temperature mechanical properties of T650-35-reinforced DMBZ-15 polyimide and PMR-15 laminates were comparable. Standard Ames tests are

  15. 42 CFR 476.71 - QIO review requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false QIO review requirements. 476.71 Section 476.71 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS UTILIZATION AND QUALITY CONTROL REVIEW Review Responsibilities of Utilization and Quality Control...

  16. 42 CFR 476.71 - QIO review requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false QIO review requirements. 476.71 Section 476.71 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS UTILIZATION AND QUALITY CONTROL REVIEW Review Responsibilities of Utilization and Quality Control...

  17. 43 CFR 10010.36 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... NATIONAL ENVIRONMENTAL POLICY ACT Environmental Impact Statements § 10010.36 Environmental review and consultation requirements. (a) The Commission will maintain a list of applicable environmental review and... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Environmental review and...

  18. 43 CFR 10010.36 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... NATIONAL ENVIRONMENTAL POLICY ACT Environmental Impact Statements § 10010.36 Environmental review and consultation requirements. (a) The Commission will maintain a list of applicable environmental review and... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Environmental review and...

  19. 43 CFR 10010.36 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... NATIONAL ENVIRONMENTAL POLICY ACT Environmental Impact Statements § 10010.36 Environmental review and consultation requirements. (a) The Commission will maintain a list of applicable environmental review and... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Environmental review and...

  20. 43 CFR 10010.36 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... NATIONAL ENVIRONMENTAL POLICY ACT Environmental Impact Statements § 10010.36 Environmental review and consultation requirements. (a) The Commission will maintain a list of applicable environmental review and... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Environmental review and...

  1. 42 CFR 412.46 - Medical review requirements: Physician acknowledgement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Medical review requirements: Physician... Capital-Related Costs § 412.46 Medical review requirements: Physician acknowledgement. (a) Basis. Because... diagnoses and major procedures performed, as evidenced by the physician's entries in the patient's...

  2. 7 CFR 1779.59 - Review of requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Review of requirements. 1779.59 Section 1779.59 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.59 Review of requirements. (a) Lender and borrower. The...

  3. 33 CFR 230.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Environmental review and consultation requirements. 230.25 Section 230.25 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE PROCEDURES FOR IMPLEMENTING NEPA § 230.25 Environmental review and consultation requirements. See 40...

  4. 40 CFR 35.3140 - Environmental review requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Environmental review requirements. 35.3140 Section 35.3140 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water Pollution Control Revolving Funds § 35.3140 Environmental review requirements. (a) Generally....

  5. Microscopic evaluation of a polyimide (PMR-15)-graphite composite

    NASA Technical Reports Server (NTRS)

    Fedderly, J. J.; Augl, J. M.

    1985-01-01

    An effort to evaluate the high temperature performance of a polyimide (PMR-15)-graphite composite which consists of several plies of woven strands of carbon fibers was undertaken. The longterm effect of high temperature on the dry material was studied by exposing polished test specimens of 473 F in a oven for nearly 400 hours. Periodically the specimens were removed and observed microscopically. Gradually surface cracks began to appear and the number of cracks increased over time. At the conclusion of the exposure the specimens were graudually ground down and observed in order to determine the depth of the cracks into the interior of the material. This procedure was repeated at an exposure temperature of 550 F.

  6. PMR-15 polyimide modifications for improved prepreg tack

    NASA Technical Reports Server (NTRS)

    Vannucci, R. D.

    1982-01-01

    The use of mixed solvents and of modified monomeric ester reactants was investigated as a means of improving the tack and drape retention characteristics of PMR-15 polyimide prepreg. Methanol, ethanol, 1-propanol and 1-butanol were used to prepare the esters, prepreg solutions, and T-300 graphite fabric and Celion 6000 unidirectional fiber prepregs. The tack retention characteristics of the T-300 fabric prepreg after exposure to simulated use conditions were determined using a simple lap shear test. Drape was qualitatively assessed by visually monitoring the deformability of the prepreg. Thermo-oxidative stability and mechanical properties retention of the Celion 6000 grahite fiber composites were determined as a function of exposure time in air at 600 F.

  7. A High T(sub g) PMR Polyimide Composites (DMBZ-15)

    NASA Technical Reports Server (NTRS)

    Chuang, Kathy C.; Bowles, Kenneth J.; Papadopoulos, Demitrios S.; Hardy-Green, DeNise; Mccorkle, Linda

    2000-01-01

    A high T(sub g) thermosetting PMR-type polyimide, designated as DMBZ-15, was developed by replacing methylene dianline (MDA) in PMR-15 with 2,2'-dimethylbenzidine. Polyimide/carbon fiber (T650-35) composites were fabricated from a formulation of 3,3', 4,4'-benzophenonetetracarboxylic acid dimethyl ester (BTDE) and 2,2'-dimethylbenzidine (DMBZ), along with nadic ester (NE) as the endcap. DMBZ-15 displays a higher glass transition temperature (T(sub g) = 414 C) than PMR-15 (T(sub g) = 345 C), and thus retains better mechanical properties for brief exposure above 400 C. The physical properties and longterm thermo-oxidative stability of the DMBZ-15 polyimide/carbon fiber composites are also compared to that of PMR-15.

  8. Characterization of PMR-15 polyimide composition in thermo-oxidatively exposed graphite fiber composites

    NASA Technical Reports Server (NTRS)

    Alston, W. B.

    1980-01-01

    The contributions of individual resin components to total resin weight loss in 600 F air aged Celion 6000/PMR-15 polyimide composites were determined from the overall resin weight loss in the composite by chemically separating the PMR-15 matrix resin into its monomeric components. The individual resin components were also analyzed by spectroscopic techniques in order to elucidate curing and degradation mechanisms of the PMR-15 matrix resin. The isothermal weight loss of the individual resin components during prolonged 600 F thermo-oxidative aging of the composite was correlated to the changes observed in the Fourier Transform infrared spectra and Fourier Transform nuclear magnetic resonance spectra of the individual resin components. The correlation was used to identify the molecular site of the thermo-oxidative changes in PMR-15 polyimide matrix resin during 600 F curing the prolonged 600 F thermo-oxidative aging.

  9. Graphite Sheet Coating for Improved Thermal Oxidative Stability of Carbon Fiber Reinforced/PMR-15 Composites

    NASA Technical Reports Server (NTRS)

    Campbell, Sandi; Papadopoulos, Demetrios; Heimann, Paula; Inghram, Linda; McCorkle, Linda

    2005-01-01

    Expanded graphite was compressed into graphite sheets and used as a coating for carbon fiber reinforced PMR-15 composites. BET analysis of the graphite indicated an increase in graphite pore size on compression, however the material was proven to be an effective barrier to oxygen when prepegged with PMR-15 resin. Oxygen permeability of the PMR-15/graphite was an order of magnitude lower than the compressed graphite sheet. By providing a barrier to oxygen permeation, the rate of oxidative degradation of PMR-15 was decreased. As a result, the composite thermo-oxidative stability increased by up to 25%. The addition of a graphite sheet as a top ply on the composites yielded little change in the material's flexural strength or interlaminar shear strength.

  10. 42 CFR 412.44 - Medical review requirements: Admissions and quality review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Medical review requirements: Admissions and quality... Capital-Related Costs § 412.44 Medical review requirements: Admissions and quality review. Beginning on... completeness, adequacy, and quality of the services furnished in the hospital. (e) Other medical or...

  11. 42 CFR 412.44 - Medical review requirements: Admissions and quality review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Medical review requirements: Admissions and quality... Capital-Related Costs § 412.44 Medical review requirements: Admissions and quality review. Beginning on... completeness, adequacy, and quality of the services furnished in the hospital. (e) Other medical or...

  12. 42 CFR 412.44 - Medical review requirements: Admissions and quality review.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Medical review requirements: Admissions and quality... Capital-Related Costs § 412.44 Medical review requirements: Admissions and quality review. Beginning on..., the following: (a) The medical necessity, reasonableness and appropriateness of hospital...

  13. 42 CFR 412.44 - Medical review requirements: Admissions and quality review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Medical review requirements: Admissions and quality... Capital-Related Costs § 412.44 Medical review requirements: Admissions and quality review. Beginning on..., the following: (a) The medical necessity, reasonableness and appropriateness of hospital...

  14. 78 FR 65744 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration... Clearance Officer, Curtis Rich, Small Business Administration, 409 3rd Street SW., 5th Floor, Washington,...

  15. 78 FR 72139 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... Program Updates notice of proposed rulemaking. (78 FR 12633). That rulemaking is still pending final... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business...

  16. 78 FR 39820 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... Business concerns. Responses: 4926. Annual Burden: 2463. Curtis Rich, Management Analyst. BILLING CODE 8025... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business...

  17. 78 FR 76378 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-17

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration... Clearance Officer, Curtis Rich, Small Business Administration, 409 3rd Street SW., 5th Floor, Washington,...

  18. 78 FR 45592 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ...: Small Business Lending Companies. Responses: 215. Annual Burden: 107.50. Curtis Rich, Management Analyst... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business...

  19. 75 FR 47034 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration..., Jacqueline White, Small Business Administration, 409 3rd Street, SW., 5th Floor, Washington, DC 20416;...

  20. 76 FR 408 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration..., Jacqueline White, Small Business Administration, 409 3rd Street, SW., 5th Floor, Washington, DC 20416;...

  1. 7 CFR 3575.59 - Review of requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE GENERAL Community Programs Guaranteed Loans § 3575.59 Review of requirements. (a) Lender and... concept, project purpose, use of proceeds, or other terms and conditions....

  2. 78 FR 28010 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration... Clearance Officer, Curtis Rich, Small Business Administration, 409 3rd Street SW., 5th Floor, Washington,...

  3. 75 FR 70339 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration..., Jacqueline White, Small Business Administration, 409 3rd Street, SW., 5th Floor, Washington, DC 20416;...

  4. 75 FR 63215 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration..., Jacqueline White, Small Business Administration, 409 3rd Street, SW., 5th Floor, Washington, DC 20416;...

  5. 78 FR 55769 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration... Clearance Officer, Curtis Rich, Small Business Administration, 409 3rd Street SW., 5th Floor, Washington,...

  6. 7 CFR 1703.312 - RUS review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false RUS review requirements. 1703.312 Section 1703.312... AGRICULTURE RURAL DEVELOPMENT Deferments of RUS Loan Payments for Rural Development Projects § 1703.312 RUS... approved by RUS. The Administrator reserves the right to review the books and copy records of...

  7. 14 CFR 415.59 - Information requirements for payload review.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Information requirements for payload review. 415.59 Section 415.59 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Payload Review and Determination §...

  8. 14 CFR 415.59 - Information requirements for payload review.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Information requirements for payload review. 415.59 Section 415.59 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Payload Review and Determination §...

  9. 14 CFR 415.59 - Information requirements for payload review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Information requirements for payload review. 415.59 Section 415.59 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Payload Review and Determination §...

  10. 14 CFR 415.59 - Information requirements for payload review.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Information requirements for payload review. 415.59 Section 415.59 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Payload Review and Determination §...

  11. 14 CFR 415.59 - Information requirements for payload review.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Information requirements for payload review. 415.59 Section 415.59 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Payload Review and Determination §...

  12. 75 FR 5812 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration... Business Administration, 409 3rd Street, SW., 5th Floor, Washington, DC 20416; and OMB Reviewer, Office...

  13. 77 FR 22056 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-12

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration... Business Administration, 409 3rd Street SW., 5th Floor, Washington, DC 20416; and OMB Reviewer, Office...

  14. 76 FR 30748 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-26

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration... Business Administration, 409 3rd Street, SW., 5th Floor, Washington, DC 20416; and OMB Reviewer, Office...

  15. 78 FR 74217 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-10

    ..., at 78 FR 53816. The changes are necessary to conform the forms to recent updates in the Lender and... proposed rulemaking. (78 FR 12633). That rulemaking is still pending final review and approval. As soon as... ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business...

  16. 14 CFR 431.25 - Application requirements for policy review.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Application requirements for policy review. 431.25 Section 431.25 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Launch...

  17. 14 CFR 435.33 - Safety review requirements and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Safety review requirements and procedures. 435.33 Section 435.33 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Safety Review and...

  18. 14 CFR 435.23 - Policy review requirements and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Policy review requirements and procedures. 435.23 Section 435.23 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and...

  19. 75 FR 23310 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ... ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration... Business Administration, 409 3rd Street, SW., 5th Floor, Washington, DC 20416; and OMB Reviewer, Office of.... SUPPLEMENTARY INFORMATION: Title: Statement of Personal History. Frequency: On Occasion. SBA Form Number:...

  20. 75 FR 24756 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration... Business Administration, 409 3rd Street, SW., 5th Floor, Washington, DC 20416; and OMB Reviewer, Office...

  1. 76 FR 45642 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ...Under the provisions of the Paperwork Reduction Act (44 U.S.C. chapter 35), agencies are required to submit proposed reporting and recordkeeping requirements to OMB for review and approval, and to publish a notice in the Federal Register notifying the public that the agency has made such a...

  2. 78 FR 76886 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...Under the provisions of the Paperwork Reduction Act (44 U.S.C. Chapter 35), agencies are required to submit proposed reporting and recordkeeping requirements to OMB for review and approval, and to publish a notice in the Federal Register notifying the public that the agency has made such a...

  3. 76 FR 52730 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ...Under the provisions of the Paperwork Reduction Act (44 U.S.C. Chapter 35), agencies are required to submit proposed reporting and recordkeeping requirements to OMB for review and approval, and to publish a notice in the Federal Register notifying the public that the agency has made such a...

  4. 33 CFR 230.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... consultation requirements. See 40 CFR 1502.25. (a) For Federal projects, NEPA documents shall be prepared..., 1979, 32 CFR part 197. Procedural requirements for Civil Works studies and projects are discussed below... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Environmental review...

  5. 42 CFR 493.555 - Federal review of laboratory requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Federal review of laboratory requirements. 493.555... SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Accreditation by a Private, Nonprofit Accreditation Organization or Exemption Under an Approved State Laboratory Program §...

  6. 78 FR 44185 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ...Under the provisions of the Paperwork Reduction Act (44 U.S.C. Chapter 35), agencies are required to submit proposed reporting and recordkeeping requirements to OMB for review and approval, and to publish a notice in the Federal Register notifying the public that the agency has made such a...

  7. 42 CFR 493.555 - Federal review of laboratory requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Federal review of laboratory requirements. 493.555... SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Accreditation by a Private, Nonprofit Accreditation Organization or Exemption Under an Approved State Laboratory Program §...

  8. 42 CFR 493.555 - Federal review of laboratory requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Federal review of laboratory requirements. 493.555... SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Accreditation by a Private, Nonprofit Accreditation Organization or Exemption Under an Approved State Laboratory Program §...

  9. 75 FR 16204 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ...Under the provisions of the Paperwork Reduction Act (44 U.S.C. Chapter 35), agencies are required to submit proposed reporting and recordkeeping requirements to OMB for review and approval, and to publish a notice in the Federal Register notifying the public that the agency has made such a...

  10. The human PMR1 endonuclease stimulates cell motility by down regulating miR-200 family microRNAs.

    PubMed

    Gu, Shan-Qing; Gallego-Perez, Daniel; McClory, Sean P; Shi, Junfeng; Han, Joonhee; Lee, L James; Schoenberg, Daniel R

    2016-07-01

    The motility of MCF-7 cells increases following expression of a human PMR1 transgene and the current study sought to identify the molecular basis for this phenotypic change. Ensemble and single cell analyses show increased motility is dependent on the endonuclease activity of hPMR1, and cells expressing active but not inactive hPMR1 invade extracellular matrix. Nanostring profiling identified 14 microRNAs that are downregulated by hPMR1, including all five members of the miR-200 family and others that also regulate invasive growth. miR-200 levels increase following hPMR1 knockdown, and changes in miR-200 family microRNAs were matched by corresponding changes in miR-200 targets and reporter expression. PMR1 preferentially cleaves between UG dinucleotides within a consensus YUGR element when present in the unpaired loop of a stem-loop structure. This motif is present in the apical loop of precursors to most of the downregulated microRNAs, and hPMR1 targeting of pre-miRs was confirmed by their loss following induced expression and increase following hPMR1 knockdown. Introduction of miR-200c into hPMR1-expressing cells reduced motility and miR-200 target gene expression, confirming hPMR1 acts upstream of Dicer processing. These findings identify a new role for hPMR1 in the post-transcriptional regulation of microRNAs in breast cancer cells. PMID:27257068

  11. The human PMR1 endonuclease stimulates cell motility by down regulating miR-200 family microRNAs

    PubMed Central

    Gu, Shan-Qing; Gallego-Perez, Daniel; McClory, Sean P.; Shi, Junfeng; Han, Joonhee; Lee, L. James; Schoenberg, Daniel R.

    2016-01-01

    The motility of MCF-7 cells increases following expression of a human PMR1 transgene and the current study sought to identify the molecular basis for this phenotypic change. Ensemble and single cell analyses show increased motility is dependent on the endonuclease activity of hPMR1, and cells expressing active but not inactive hPMR1 invade extracellular matrix. Nanostring profiling identified 14 microRNAs that are downregulated by hPMR1, including all five members of the miR-200 family and others that also regulate invasive growth. miR-200 levels increase following hPMR1 knockdown, and changes in miR-200 family microRNAs were matched by corresponding changes in miR-200 targets and reporter expression. PMR1 preferentially cleaves between UG dinucleotides within a consensus YUGR element when present in the unpaired loop of a stem–loop structure. This motif is present in the apical loop of precursors to most of the downregulated microRNAs, and hPMR1 targeting of pre-miRs was confirmed by their loss following induced expression and increase following hPMR1 knockdown. Introduction of miR-200c into hPMR1-expressing cells reduced motility and miR-200 target gene expression, confirming hPMR1 acts upstream of Dicer processing. These findings identify a new role for hPMR1 in the post-transcriptional regulation of microRNAs in breast cancer cells. PMID:27257068

  12. Properties of PMR polyimide composites made with improved high strength graphite fibers

    NASA Technical Reports Server (NTRS)

    Vannucci, R. D.

    1980-01-01

    Recent graphite fiber developments have resulted in high strength, intermediate modulus graphite fibers having improved thermo-oxidative resistance. These improved fibers, obtained from various commercial suppliers, were used to fabricate PMR-15 and PMR-11 polyimide composites. Studies were performed to investigate the effects of the improved high strength graphite fibers on composite properties after exposure in air at 600 F. The use of the more oxidatively resistant fibers did not result in improved performance at 600 F. Two of the improved fibers were found to have an adverse effect on the long-term performance of PMR composites. The influence of various factors such as fiber physical properties, surface morphology and chemical composition are also discussed.

  13. Influence of excess diamine on properties of PMR polyimide resins and composites

    NASA Technical Reports Server (NTRS)

    Hurwitz, F. I.

    1980-01-01

    By varying the stoichiometry of the reactants in the preparation of PMR polyimide resin, changes occur in molecular weight distribution which influence the rheological properties and thus the processability of the resin, as well as the mechanical properties of the composite. The influence of 1-10 percent molar excess MDA on the molecular weight distribution and rheological properties of an imidized PMR system were exposed. Molecular weight distribution is characterized by gel permeation chromatography of the imidized molding compound; shear viscosity is related to changes in average molecular weight. The thermo-oxidative stability at 600 F, glass transition temperature, flexural and interlaminar shear properties of PMR polyimide/Celion 6000 graphite fiber composites are compared as a function of the percent excess MDA in the monomer reactant mixture.

  14. Effect of solution concentration and aging conditions on PMR-15 resin

    NASA Technical Reports Server (NTRS)

    Roberts, G. D.; Vannucci, R. D.

    1986-01-01

    High performance liquid chromatography is utilized to evaluate the effect of temperature, solution concentration, and aging time on PMR-15 resin solutions. Fifty- and 70-wt percent PMR-15 resin solutions were prepared from the mixture of 5-norbornene-2,3-dicarboxylic ester (NE) acid, 4.4'-methylenedianiline (MDA), methanol, and 3,3',4.4.-benzophenonetetracarboxylic dimethyl ester (BTDE) acid solution. It is observed that in PMR-15 resin solution aged for 35 days at room temperature NE and MDA react to form amide and imide intermediates. The precipitation data reveal that in the 70-wt percent solution precipitation occurs after 12 days and in the 50-wt percent solution after 20 days; however, at lower temperatures (-11 C, and 2 C) no precipitation is detected. It is concluded that storage of resin solutions and powders at reduced temperatures extends shelf life by reducing the rate of imide formation.

  15. 7 CFR 1794.3 - Actions requiring environmental review.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true Actions requiring environmental review. 1794.3 Section... of financial assistance pursuant to the Electric, Telecommunications, and Water and Waste Programs, the disposal of property held by RUS pursuant to such programs, and the issuance of new or...

  16. 78 FR 65744 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration... Clearance Officer, Curtis Rich, Small Business Administration, 409 3rd Street SW., 5th Floor, Washington, DC... used by Small Business Administration (SBA) examiners as part of their examination of licensed...

  17. 77 FR 68881 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-16

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration..., Curtis Rich, Curtis.rich@sba.gov Small Business Administration, 409 3rd Street SW., 5th Floor,...

  18. 77 FR 19050 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration..., Curtis Rich, Small Business Administration, 409 3rd Street SW., 5th Floor, Washington, DC 20416; and...

  19. 42 CFR 493.555 - Federal review of laboratory requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Federal review of laboratory requirements. 493.555 Section 493.555 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... of CMS, including, but not limited to, inspection frequency and the ability to investigate...

  20. 40 CFR 35.3580 - Environmental review requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... consequences on the existing environment, the future environment, and individual sensitive environmental issues... procedures at 40 CFR part 6 and related subparts or apply its own “NEPA-like” SERP for conducting... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Environmental review requirements....

  1. 40 CFR 35.3580 - Environmental review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... consequences on the existing environment, the future environment, and individual sensitive environmental issues... procedures at 40 CFR part 6 and related subparts or apply its own “NEPA-like” SERP for conducting... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Environmental review requirements....

  2. 40 CFR 35.3580 - Environmental review requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... consequences on the existing environment, the future environment, and individual sensitive environmental issues... procedures at 40 CFR part 6 and related subparts or apply its own “NEPA-like” SERP for conducting... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Environmental review requirements....

  3. 40 CFR 35.3580 - Environmental review requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... consequences on the existing environment, the future environment, and individual sensitive environmental issues... procedures at 40 CFR part 6 and related subparts or apply its own “NEPA-like” SERP for conducting... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Environmental review requirements....

  4. 40 CFR 35.3580 - Environmental review requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... consequences on the existing environment, the future environment, and individual sensitive environmental issues... procedures at 40 CFR part 6 and related subparts or apply its own “NEPA-like” SERP for conducting... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Environmental review requirements....

  5. 77 FR 70525 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration..., Curtis Rich, Curtis.rich@sba.gov , Small Business Administration, 409 3rd Street SW., 5th...

  6. 42 CFR 412.46 - Medical review requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Medical review requirements. 412.46 Section 412.46... Prospective Payment Systems for Inpatient Operating Costs and Inpatient Capital-Related Costs § 412.46 Medical... performed, as evidenced by the physician's entries in the patient's medical record, physicians must...

  7. 77 FR 38704 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-28

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration...@sba.gov Small Business Administration, 409 3rd Street SW., 5th Floor, Washington, DC 20416; and...

  8. 43 CFR 46.430 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... IMPLEMENTATION OF THE NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Environmental Impact Statements § 46.430 Environmental review and consultation requirements. (a) Any environmental impact statement that also addresses.... The environmental impact statement must include these associated analyses, studies, or surveys,......

  9. 43 CFR 46.430 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... IMPLEMENTATION OF THE NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Environmental Impact Statements § 46.430 Environmental review and consultation requirements. (a) Any environmental impact statement that also addresses.... The environmental impact statement must include these associated analyses, studies, or surveys,......

  10. 43 CFR 46.430 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... IMPLEMENTATION OF THE NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Environmental Impact Statements § 46.430 Environmental review and consultation requirements. (a) Any environmental impact statement that also addresses.... The environmental impact statement must include these associated analyses, studies, or surveys,......

  11. 43 CFR 46.430 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... IMPLEMENTATION OF THE NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Environmental Impact Statements § 46.430 Environmental review and consultation requirements. (a) Any environmental impact statement that also addresses.... The environmental impact statement must include these associated analyses, studies, or surveys,......

  12. 48 CFR 801.602-71 - Basic review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Basic review requirements. 801.602-71 Section 801.602-71 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL DEPARTMENT OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development,...

  13. 42 CFR 412.46 - Medical review requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Medical review requirements. 412.46 Section 412.46... Prospective Payment Systems for Inpatient Operating Costs and Inpatient Capital-Related Costs § 412.46 Medical... performed, as evidenced by the physician's entries in the patient's medical record, physicians must...

  14. 77 FR 14853 - Reporting and Recordkeeping Requirements Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Reporting and Recordkeeping Requirements Under OMB Review AGENCY: Small Business Administration..., Curtis Rich, Small Business Administration, 409 3rd Street SW., 5th Floor, Washington, DC 20416; and...

  15. 18 CFR 806.4 - Projects requiring review and approval.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... requiring review and approval as set forth in this section, § 806.5, or 18 CFR part 801. The taking or... § 806.5 or 18 CFR part 801. Such project sponsors shall be notified in writing by the Executive Director... forage crops, trees, flowers, shrubs, turf products, livestock, or poultry, or for aquaculture, to...

  16. 18 CFR 806.4 - Projects requiring review and approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... requiring review and approval as set forth in this section, § 806.5, or 18 CFR part 801. (i) Any project... determined by the commissioners or Executive Director pursuant to § 806.5 or 18 CFR part 801. Such project...) Transfer of land used primarily for the raising of food, fiber or forage crops, trees, flowers,...

  17. 18 CFR 806.4 - Projects requiring review and approval.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... requiring review and approval as set forth in this section, § 806.5, or 18 CFR part 801. The taking or... § 806.5 or 18 CFR part 801. Such project sponsors shall be notified in writing by the Executive Director... forage crops, trees, flowers, shrubs, turf products, livestock, or poultry, or for aquaculture, to...

  18. 18 CFR 806.4 - Projects requiring review and approval.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... requiring review and approval as set forth in this section, § 806.5, or 18 CFR part 801. The taking or... determined by the commissioners or Executive Director pursuant to § 806.5 or 18 CFR part 801. Such project...) Transfer of land used primarily for the raising of food, fiber or forage crops, trees, flowers,...

  19. 18 CFR 806.4 - Projects requiring review and approval.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... requiring review and approval as set forth in this section, § 806.5, or 18 CFR part 801. The taking or... § 806.5 or 18 CFR part 801. Such project sponsors shall be notified in writing by the Executive Director... forage crops, trees, flowers, shrubs, turf products, livestock, or poultry, or for aquaculture, to...

  20. 42 CFR 412.508 - Medical review requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Medical review requirements. 412.508 Section 412.508 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PROSPECTIVE PAYMENT SYSTEMS FOR INPATIENT HOSPITAL SERVICES Prospective Payment System for Long-Term Care Hospitals § 412.508...

  1. 48 CFR 801.602-70 - General review requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false General review requirements. 801.602-70 Section 801.602-70 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL DEPARTMENT OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career...

  2. Manufacturing processes for fabricating graphite/PMR 15 polyimide structural elements

    NASA Technical Reports Server (NTRS)

    Sheppard, C. H.; Hoggatt, J. T.; Symonds, W. A.

    1979-01-01

    Investigations were conducted to obtain commercially available graphite/PMR-15 polyimide prepreg, develop an autoclave manufacturing process, and demonstrate the process by manufacturing structural elements. Controls were established on polymer, prepreg, composite fabrication, and quality assurance, Successful material quality control and processes were demonstrated by fabricating major structural elements including flat laminates, hat sections, I beam sections, honeycomb sandwich structures, and molded graphite reinforced fittings. Successful fabrication of structural elements and simulated section of the space shuttle aft body flap shows that the graphite/PMR-15 polyimide system and the developed processes are ready for further evaluation in flight test hardware.

  3. Replacement of MDA with more oxidatively stable diamines in PMR-polyimides

    NASA Technical Reports Server (NTRS)

    Alston, W. B.

    1985-01-01

    Studies are performed to investigate the effect of substituting 4,4'-oxydianiline and 1,1-bis(4-aminophenyl)-1-phenyl-2,2,2-trifluoroethane for the 4,4'-methylenedianiline in PMR polyimide matrix resin. Graphite fiber reinforced composites are fabricated from unsized Celion 6000 and PMR-polyimide matrix resins having formulated molecular weights in the range of 1500 to 2400. The composite processing characteristics are investigated and the initial room temperature and 316 C (600 F) composite mechanical properties are determined. Comparative 316 C composite weight losses and 316 C mechanical properties retention after prolonged 316 C air exposure are also determined.

  4. The synthesis, characterization and thermal chemistry of modified norbornenyl PMR endcaps

    NASA Technical Reports Server (NTRS)

    Sukenik, C. N.; Ritchey, W. M.; Malhotra, V.; Varde, U.

    1985-01-01

    As part of a program to further the understanding of the polymerization of Nadic-Endcapped PMR systems, a series of model Norbornenyl-Imides has been synthesized and their thermal behavior explored. Their syntheses and characterizations as well as their rearrangement and polymerization chemistry are described. Monomer isomerization at temperatures as low as 125 C and oligomer formation at somewhat higher temperatures are observed. Approximate relative rates for competing isomerization pathways are established and some information is obtained about the details of oligomer formation. The relationship of this data to current PMR systems is briefly discussed.

  5. Absence of PmrAB-Mediated Phosphoethanolamine Modifications of Citrobacter rodentium Lipopolysaccharide Affects Outer Membrane Integrity▿†

    PubMed Central

    Viau, Charles; Le Sage, Valerie; Ting, Daniel K.; Gross, Jeremy; Le Moual, Hervé

    2011-01-01

    The PmrAB two-component system of enterobacteria regulates a number of genes whose protein products modify lipopolysaccharide (LPS). The LPS is modified during transport to the bacterial outer membrane (OM). A subset of PmrAB-mediated LPS modifications consists of the addition of phosphoethanolamine (pEtN) to lipid A by PmrC and to the core by CptA. In Salmonella enterica, pEtN modifications have been associated with resistance to polymyxin B and to excess iron. To investigate putative functions of pEtN modifications in Citrobacter rodentium, ΔpmrAB, ΔpmrC, ΔcptA, and ΔpmrC ΔcptA deletion mutants were constructed. Compared to the wild type, most mutant strains were found to be more susceptible to antibiotics that must diffuse across the LPS layer of the OM. All mutant strains also showed increased influx rates of ethidium dye across their OM, suggesting that PmrAB-regulated pEtN modifications affect OM permeability. This was confirmed by increased partitioning of the fluorescent dye 1-N-phenylnaphthylamine (NPN) into the OM phospholipid layer of the mutant strains. In addition, substantial release of periplasmic β-lactamase was observed for the ΔpmrAB and ΔpmrC ΔcptA strains, indicating a loss of OM integrity. This study attributes a new role for PmrAB-mediated pEtN LPS modifications in the maintenance of C. rodentium OM integrity. PMID:21378194

  6. High-Flow PMR-Polymide Composites Developed With Mechanical Properties Comparable to Other High-Temperature Systems

    NASA Technical Reports Server (NTRS)

    Meador, Michael A.

    2001-01-01

    PMR polyimides, in particular PMR-15, are well known for their excellent high-temperature stability and performance, and solvent resistance. However, the processing of these materials is limited, for the most part, to prepreg-based methods, such as compression or autoclave processing. These methods involve substantial amounts of hand labor, and as a result, manufacturing costs for components made from PMR polyimides can be high. In cost-sensitive applications, these high manufacturing costs can make the use of PMR polyimide-based components cost prohibitive. Lower cost manufacturing methods, such as resin transfer molding (RTM) and resin film infusion, have been demonstrated to reduce manufacturing costs by as much as 50 percent over prepreg-based methods. However, these processes are only amenable to materials with melt viscosities below 30 poise. Most PMR polyimides have melt viscosities on the order of 100 poise or higher. Recent efforts at the NASA Glenn Research Center have focused on chemical modifications to PMR polyimides to reduce their melt viscosity to the point where they could be processed by these low-cost manufacturing methods without adversely affecting their high-temperature properties and performance. These efforts have led to a new family of PMR polyimides that have melt viscosities significantly lower than that of PMR-15. Reductions in melt viscosity are brought about through the introduction of molecular twists in the polymer backbone. Carbon fiber (T650- 35) composites were prepared from one of these polyimides, designated PMR-Flex, by compression molding. The properties of these composites are presented below and compared with comparable composites made from PMR-15 and PETI-RTM, a new low-melt-viscosity polyimide.

  7. 42 CFR 412.44 - Medical review requirements: Admissions and quality review.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Medical review requirements: Admissions and quality review. 412.44 Section 412.44 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PROSPECTIVE PAYMENT SYSTEMS FOR INPATIENT HOSPITAL SERVICES Conditions for Payment Under the...

  8. ESA-SSA Review of Space Weather Measurement Requirements

    NASA Astrophysics Data System (ADS)

    Luntama, Juha-Pekka; Glover, Alexi; Hilgers, Alain

    2012-07-01

    The ESA Space Situational Awareness (SSA) Preparatory Programme was started in 2009. The objective of the programme is to support the European independent utilisation of and access to space. The first phase of the ESA SSA system development will be finished in 2012 and the next phase is foreseen to be started after the ESA Ministerial Council meeting in November 2012. The definition of measurement requirements for the Space Weather Segment (SWE) of the ESA SSA system has been based on the space weather service requirements defined the by expected users of the system. This document, SSA SWE Customer Requirements Document (CRD), has been defined in a iterative process together with the members of the SSA User Representative Group (URG) and the delegates representing the European states participating the programme. Based on the SWE CRD, ESA with the support of the European industry has produced two documents: SSA SWE System Requirements Document (SRD) and SSA SWE Product Specification (PS). SWE PS contains the requirements for the measurements data required by the SSA SWE system. The SWE PS document has been recently rigorously reviewed by the SSA URG in the framework of the SSA System Requirements Review (SRR). The support provided by the Steering Board of the ESA Space Weather Working Team (SWWT) in this review was extremely useful. The members of the SWWT SB representing the scientific community and the provisional service providers were able to give very detailed comments regarding the measurement requirements for accuracy, cadence, timeliness, etc. As these parameters will be provisional design and cost drivers for the ESA SSA system, definition of the appropriate values at this point in the programme is crucial. This paper provides an overview of the measurement requirements for the SWE Segment of the ESA SSA Programme. The paper discusses the requirement definition process, the customer and service provider inputs, and the critical requirements as they have

  9. Effect of substituted phenylnadimides on processing and properties of PMR polyimide composites

    NASA Technical Reports Server (NTRS)

    Alston, W. B.; Lauver, R. W.

    1985-01-01

    Three nitrophenylnadimide cure initiators and two phenylnadimides (without nitros) were evaluated as additives to PMR-15 resins and Celion 6000 graphite fiber composites. The results of a resin screening study eliminated all of the additives except 3-nitrophenylnadimide (NO2PN) for use as a low temperature curing additive for PMR-15. Thus, NO2PN and the two control additives were investigated in PMR-15 formulations from which Celion 6000 graphite fiber/PMR-15 composites were processed both with low temperature (274 C) and normal (316 C) cure cycles. Comparisons of the two processing cycles, the resultant glass transition temperatures (Tg), the ambient, 274 and 316 C composite mechanical properties determined before and after 316 C postcure, the 316 C thermo-oxidative weight losses and the retention of 316 C composite mechanical properties are presented. Empirical correlations of the type and amount of nadimide additives with processing parameters, Tg, composite mechanical properties, composite thermo-oxidative stability and long term retention of 316 C composite mechanical properties are also presented.

  10. Structural Evolution and Mechanical Properties of PMR-15/Layered Silicate Nanocomposites

    NASA Technical Reports Server (NTRS)

    Campbell, Sandi (Technical Monitor); Dean, Derrick; Abdalla, Mohamed; Green, Keith; Small, Sharee

    2003-01-01

    In the first year of this research, we successfully synthesized and characterized Polymer/ Layered Silicate nanocomposite using the polyimide PMR-15 as the polymer and several layered silicate nanoparticles. We have scaled up the process to allow fabrication of monoliths using these nanocomposites. The morphology of these systems was found to evolve during processing to an exfoliated structure for one system and intercalated for the rest. Correlation with Transmission Electron Microscopy studies is underway. Dynamic mechanical analysis (DMA) results showed a significant increase in the thermomechanical properties (E' and E'') of 2.5 wt.% clay loaded nanocomposites in comparison to the neat polyimide. Increasing the clay loading to 5 wt.% decreased these properties. Higher glass transition temperatures were observed for 2.5 wt.% nanocomposites compared to the neat polyimide. A lower coefficient of thermal expansion was observed only for the PGV/PMR-15 nanocomposite. An improvement in the flexural properties (modulus, strength and elongation) was observed for the 2.5 wt.% nanocomposite but not for the 5 wt.% nanocomposites. The improved barrier properties polymer/ silicate nanocomposites suggest that moisture uptake should be decreased for PMR-15 nanocomposites. The results of some recent experiments to examine delineate the ability of the silicate nanoparticles in improving the hydrolytic degradation of PMR-15 will be discussed.

  11. PmrB Mutations Promote Polymyxin Resistance of Pseudomonas aeruginosa Isolated from Colistin-Treated Cystic Fibrosis Patients

    PubMed Central

    Brannon, Mark K.; Dasgupta, Nandini; Pier, Miyuki; Sgambati, Nicole; Miller, Amanda K.; Selgrade, Sara E.; Miller, Samuel I.; Denton, Miles; Conway, Steven P.; Johansen, Helle K.; Høiby, Niels

    2012-01-01

    Pseudomonas aeruginosa can develop resistance to polymyxin and other cationic antimicrobial peptides. Previous work has shown that mutations in the PmrAB and PhoPQ regulatory systems can confer low to moderate levels of colistin (polymyxin E) resistance in laboratory strains and clinical isolates of this organism (MICs of 8 to 64 mg/liter). To explore the role of PmrAB in high-level clinical polymyxin resistance, P. aeruginosa isolates from chronically colistin-treated cystic fibrosis patients, most with colistin MICs of >512 mg/liter, were analyzed. These cystic fibrosis isolates contained probable gain-of-function pmrB alleles that conferred polymyxin resistance to strains with a wild-type or pmrAB deletion background. Double mutant pmrB alleles that contained mutations in both the periplasmic and dimerization-phosphotransferase domains markedly augmented polymyxin resistance. Expression of mutant pmrB alleles induced transcription from the promoter of the arnB operon and stimulated addition of 4-amino-l-arabinose to lipid A, consistent with the known role of this lipid A modification in polymyxin resistance. For some highly polymyxin-resistant clinical isolates, repeated passage without antibiotic selection pressure resulted in loss of resistance, suggesting that secondary suppressors occur at a relatively high frequency and account for the instability of this phenotype. These results indicate that pmrB gain-of-function mutations can contribute to high-level polymyxin resistance in clinical strains of P. aeruginosa. PMID:22106224

  12. Development of DMBZ-15 High-Glass-Transition-Temperature Polyimides as PMR-15 Replacements Given R&D 100 Award

    NASA Technical Reports Server (NTRS)

    Chuang, Kathy

    2004-01-01

    PMR-15, a high-temperature polyimide developed in the mid-1970s at the NASA Lewis Research Center,1 offers the combination of low cost, easy processing, and good high-temperature performance and stability. It has been recognized as the leading polymer matrix resin for carbon-fiber-reinforced composites used in aircraft engine components. The state-of-the-art PMR-15 polyimide composite has a glass-transition temperature (Tg) of 348 C (658 F). Since composite materials must be used at temperatures well below their glass-transition temperature, the long-term use temperatures of PMR-15 composites can be no higher than 288 C (550 F). In addition, PMR-15 is made from methylene dianiline (MDA), a known liver toxin. Concerns about the safety of workers exposed to MDA during the fabrication of PMR-15 components and about the environmental impact of PMR-15 waste disposal have led to the industry-wide implementation of special handling procedures to minimize the health risks associated with this material. These procedures have increased manufacturing and maintenance costs significantly and have limited the use of PMR-15 in commercial aircraft engine components.

  13. Rotorcraft aviation icing research requirements: Research review and recommendations

    NASA Technical Reports Server (NTRS)

    Peterson, A. A.; Dadone, L.; Bevan, A.

    1981-01-01

    The status of rotorcraft icing evaluation techniques and ice protection technology was assessed. Recommendations are made for near and long term icing programs that describe the needs of industry. These recommended programs are based on a consensus of the major U.S. helicopter companies. Specific activities currently planned or underway by NASA, FAA and DOD are reviewed to determine relevance to the overall research requirements. New programs, taking advantage of current activities, are recommended to meet the long term needs for rotorcraft icing certification.

  14. Review of orders and regulations requiring environmental protection

    SciTech Connect

    Kelly, E.; Cunningham, R.; Michael, D.

    1996-09-01

    With the increased awareness of and interest in potential ecological risks associated with past, current, and future Department of Energy (DOE) activities, DOE`s Defense Programs (DP) Office of Technical and Environmental Support sponsored a study to (1) evaluate the effectiveness of the current compliance-driven environmental protection and assessment efforts relative to ecological concerns; (2) explore the need for a more focused, integrated approach to address ecological impacts; and (3) identify the requirements for an integrated approach. The study explored four questions. (a) Which federal regulations and DOE orders either explicitly require ecological assessments or implicitly require them through environmental protection language? (b) What currently is being done at selected DOE facilities to implement these regulations and orders? (c) What are private sector industries doing in terms of ecological risk assessments and how do industry approaches and issues compare with those of DOE? (d) What, if anything, in addition to current efforts is needed to ensure the protection of ecological resources associated with DOE facilities, to support defensible decision making, and to improve efficiency? The results of this study are presented in a report titled {open_quotes}Integrated, Comprehensive Ecological Impact Assessments In Support of Department of Energy Decision Making{close_quotes}. This report is a companion document to that report. This report provides a more detailed discussion of the document reviews of the relevant environmental protection regulations and current and pending DOE orders. The main goal of the document reviews was to understand existing requirements for ecological data collection and impact assessments.

  15. Accuracy of musculoskeletal imaging for the diagnosis of polymyalgia rheumatica: systematic review

    PubMed Central

    Mackie, Sarah Louise; Koduri, Gouri; Hill, Catherine L; Wakefield, Richard J; Hutchings, Andrew; Loy, Clement; Dasgupta, Bhaskar; Wyatt, Jeremy C

    2015-01-01

    Objectives To review the evidence for accuracy of imaging for diagnosis of polymyalgia rheumatica (PMR). Methods Searches included MEDLINE, EMBASE and PubMed. Evaluations of diagnostic accuracy of imaging tests for PMR were eligible, excluding reports with <10 PMR cases. Two authors independently extracted study data and three authors assessed methodological quality using modified QUADAS-2 criteria. Results 26 studies of 2370 patients were evaluated: 10 ultrasound scanning studies; 6 MRI studies; 1 USS and MRI study; 7 18-fluorodeoxyglucose-positron emission tomography (PET) studies; 1 plain radiography and 1 technetium scintigraphy study. In four ultrasound studies, subacromial-subdeltoid bursitis had sensitivity 80% (95% CI 55% to 93%) and specificity 68% (95% CI 60% to 75%), whereas bilateral subacromial-subdeltoid bursitis had sensitivity 66% (95% CI 43% to 87%) and specificity 89% (95% CI 66% to 97%). Sensitivity for ultrasound detection of trochanteric bursitis ranged from 21% to 100%. In four ultrasound studies reporting both subacromial-subdeltoid bursitis and glenohumeral synovitis, detection of subacromial-subdeltoid bursitis was more accurate than that of glenohumeral synovitis (p=0.004). MRI and PET/CT revealed additional areas of inflammation in the spine and pelvis, including focal areas between the vertebrae and anterior to the hip joint, but the number of controls with inflammatory disease was inadequate for precise specificity estimates. Conclusions Subacromial-subdeltoid bursitis appears to be the most helpful ultrasound feature for PMR diagnosis, but interpretation is limited by study heterogeneity and methodological issues, including variability in blinding and potential bias due to case–control study designs. Recent MRI and PET/CT case–control studies, with blinded readers, yielded promising data requiring validation within a diagnostic cohort study. PMID:26535139

  16. 18 CFR 806.5 - Projects that may require review and approval.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... require review and approval. 806.5 Section 806.5 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION REVIEW AND APPROVAL OF PROJECTS General Provisions § 806.5 Projects that may require review and approval. (a) The following projects, if not otherwise requiring review and...

  17. 18 CFR 806.5 - Projects that may require review and approval.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... require review and approval. 806.5 Section 806.5 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION REVIEW AND APPROVAL OF PROJECTS General Provisions § 806.5 Projects that may require review and approval. (a) The following projects, if not otherwise requiring review and...

  18. Studies on Hot-Melt Prepregging of PMR-II-50 Polyimide Resin with Graphite Fibers

    NASA Technical Reports Server (NTRS)

    Shin, E. Eugene; Sutter, James K.; Juhas, John; Veverka, Adrienne; Klans, Ojars; Inghram, Linda; Scheiman, Dan; Papadopoulos, Demetrios; Zoha, John; Bubnick, Jim

    2003-01-01

    A Second generation PMR (in situ Polymerization of Monomer Reactants) polyimide resin, PMR-II-50, has been considered for high temperature and high stiffness space propulsion composites applications for its improved high temperature performance. As part of composite processing optimization, two commercial prepregging methods: solution vs. hot-melt processes were investigated with M40J fabrics from Toray. In a previous study a systematic chemical, physical, thermal and mechanical characterization of these composites indicated that poor resin-fiber interfacial wetting, especially for the hot-melt process, resulted in poor composite quality. In order to improve the interfacial wetting, optimization of the resin viscosity and process variables were attempted in a commercial hot-melt prepregging line. In addition to presenting the results from the prepreg quality optimization trials, the combined effects of the prepregging method and two different composite cure methods, i.e., hot press vs. autoclave on composite quality and properties are discussed.

  19. Development of Processable PMR-Type Polymides with Star-Branched Structures

    NASA Technical Reports Server (NTRS)

    Nguyen, Baochau N.; Eby, R. K.; Meador, Michael A.

    1999-01-01

    In the last two decades, high temperature polyimide matrix composites have found broad applications in aerospace structural components, due to their high specific modulus and high specific strength. As matrix resins, aromatic polyimides exhibit exceptional thermal stability and mechanical properties. However, their rodlike structures often result in poor solubility in most common organic solvents, as well as high melt temperature and melt viscosity, making them difficult to process. To overcome this difficulty, flexible linkages including O, SO2 or CH2 non coplanar biphenyl moieties, bulky lateral substituents, and crankshaft structures are often incorporated into the polymer backbones. Addition-curing of low molecular weight polyimides (resins) is another approach to improve processability. One of the most successfully developed materials has been PMR-15 (Polymerization of Monomer Reactants, molecular weight of 1500 g/mol), because of its good combination of thermal and mechanical properties and ease of processability. However, due to the high melt viscosity of PMR-type resins, use of more economical processing methods, such as resin transfer molding (RTM), is not possible. Recent research has focused on the incorporation of trifunctional monomers into addition-curing polyimides in an attempt to improve the processability of these polymers. The objective of this research is to use an aromatic triamine, 1,3,5 tris (4-aminophenoxy) benzene, to prepare new resin systems with starbranched structures. The glass transition temperatures (Tg's) and thermal oxidative stability TOS) of these polymers are compared to their linear counterparts and PMR-15.

  20. 48 CFR 749.111-71 - Required review and approval.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... activity concerned determines that a review of a specific case or class of cases is desirable; or (4) The contracting officer, in his/her discretion, desires review by the board. (b) Level of review....

  1. Differentiation between Polymyalgia Rheumatica (PMR) and Elderly-Onset Rheumatoid Arthritis Using 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography: Is Enthesitis a New Pathological Lesion in PMR?

    PubMed Central

    Wakura, Daisuke; Kotani, Takuya; Takeuchi, Tohru; Komori, Tsuyoshi; Yoshida, Shuzo; Makino, Shigeki; Hanafusa, Toshiaki

    2016-01-01

    Background It is difficult to differentiate polymyalgia rheumatica (PMR) from elderly-onset rheumatoid arthritis (EORA) in clinical practice. We compared FDG-PET/CT findings between patients with PMR and those with EORA and extracted factors useful for differentiating the two disorders. Methods We compared abnormal FDG accumulation sites and maximum standardized uptake value (SUVmax) between 15 patients with PMR and 7 with EORA in whom FDG-PET/CT was performed. Results The proportion of patients in the PMR group with abnormal FDG accumulation at the following 9 sites on FDG-PET/CT was significantly higher than that in the EORA group: periarticular region of the scapulohumeral joint, enthesis of the pectineus muscle, vicinity of the enthesis of the rectus femoris muscle, lateral side of the greater trochanter, ischial tuberosity, hip joint, spinous process of the lower cervical vertebra, intervertebral joint of the lumbar vertebra, and spinous process of the lumbar vertebra. The PET/CT score was evaluated at 9 sites consisting of the abovementioned sites. The median score in the PMR group was 8, which was significantly higher than that of 0 in the EORA group (P = 0.0003). ROC curve analysis was performed with the PET/CT scores, and a score of 5 was shown to maximize the area under the ROC curve (sensitivity: 86.7%, specificity: 86.7%). Conclusions FDG-PET/CT is useful for differentiating PMR from EORA. In patients with PMR, abnormal FDG accumulation was observed at the entheses, suggesting the presence of enthesitis in addition to bursitis and synovitis. PMID:27384410

  2. A review of medical image watermarking requirements for teleradiology.

    PubMed

    Nyeem, Hussain; Boles, Wageeh; Boyd, Colin

    2013-04-01

    Teleradiology allows medical images to be transmitted over electronic networks for clinical interpretation and for improved healthcare access, delivery, and standards. Although such remote transmission of the images is raising various new and complex legal and ethical issues, including image retention and fraud, privacy, malpractice liability, etc., considerations of the security measures used in teleradiology remain unchanged. Addressing this problem naturally warrants investigations on the security measures for their relative functional limitations and for the scope of considering them further. In this paper, starting with various security and privacy standards, the security requirements of medical images as well as expected threats in teleradiology are reviewed. This will make it possible to determine the limitations of the conventional measures used against the expected threats. Furthermore, we thoroughly study the utilization of digital watermarking for teleradiology. Following the key attributes and roles of various watermarking parameters, justification for watermarking over conventional security measures is made in terms of their various objectives, properties, and requirements. We also outline the main objectives of medical image watermarking for teleradiology and provide recommendations on suitable watermarking techniques and their characterization. Finally, concluding remarks and directions for future research are presented. PMID:22975883

  3. Protein Requirements and Recommendations for Older People: A Review

    PubMed Central

    Nowson, Caryl; O’Connell, Stella

    2015-01-01

    Declines in skeletal muscle mass and strength are major contributors to increased mortality, morbidity and reduced quality of life in older people. Recommended Dietary Allowances/Intakes have failed to adequately consider the protein requirements of the elderly with respect to function. The aim of this paper was to review definitions of optimal protein status and the evidence base for optimal dietary protein. Current recommended protein intakes for older people do not account for the compensatory loss of muscle mass that occurs on lower protein intakes. Older people have lower rates of protein synthesis and whole-body proteolysis in response to an anabolic stimulus (food or resistance exercise). Recommendations for the level of adequate dietary intake of protein for older people should be informed by evidence derived from functional outcomes. Randomized controlled trials report a clear benefit of increased dietary protein on lean mass gain and leg strength, particularly when combined with resistance exercise. There is good consistent evidence (level III-2 to IV) that consumption of 1.0 to 1.3 g/kg/day dietary protein combined with twice-weekly progressive resistance exercise reduces age-related muscle mass loss. Older people appear to require 1.0 to 1.3 g/kg/day dietary protein to optimize physical function, particularly whilst undertaking resistance exercise recommendations. PMID:26287239

  4. Protein Requirements and Recommendations for Older People: A Review.

    PubMed

    Nowson, Caryl; O'Connell, Stella

    2015-08-01

    Declines in skeletal muscle mass and strength are major contributors to increased mortality, morbidity and reduced quality of life in older people. Recommended Dietary Allowances/Intakes have failed to adequately consider the protein requirements of the elderly with respect to function. The aim of this paper was to review definitions of optimal protein status and the evidence base for optimal dietary protein. Current recommended protein intakes for older people do not account for the compensatory loss of muscle mass that occurs on lower protein intakes. Older people have lower rates of protein synthesis and whole-body proteolysis in response to an anabolic stimulus (food or resistance exercise). Recommendations for the level of adequate dietary intake of protein for older people should be informed by evidence derived from functional outcomes. Randomized controlled trials report a clear benefit of increased dietary protein on lean mass gain and leg strength, particularly when combined with resistance exercise. There is good consistent evidence (level III-2 to IV) that consumption of 1.0 to 1.3 g/kg/day dietary protein combined with twice-weekly progressive resistance exercise reduces age-related muscle mass loss. Older people appear to require 1.0 to 1.3 g/kg/day dietary protein to optimize physical function, particularly whilst undertaking resistance exercise recommendations. PMID:26287239

  5. Development of processable PMR-type polyimides for high temperature applications

    NASA Astrophysics Data System (ADS)

    Nguyen, Baochau Ngoc

    PMR-15 is an industrial standard polyimide for high temperature performance in aerospace applications. The objectives of this research were to develop environmentally friendly branched PMR-type polyimides with comparable thermal and mechanical properties and improved melt flow and processability compared to PMR-15. An aromatic triamine, 1,3,5-tris(4-aminophenoxy)benzene was used in the development of these branched polymers. This work consisted of three parts. The first part was a screening study of four different diamine-based branched polyimides of varying formulated molecular weights. In these series, the aromatic triamine was utilized as the hub of the polymer molecules which were endcapped with a nadic ester acid. Thermal and mechanical properties of oligomers (resins), neat polymers, and selected carbon fabric reinforced polyimide composites were investigated. Results showed that branched polymers displayed higher glass transition temperatures (Tg's) than their corresponding linear systems due to a higher crosslink density, but had lower thermal oxidative stability (TOS), due to higher nadic ester content and the presence of ether linkages in the triamine, TAB. Mechanical properties including interlaminar shear, flexural strength, flexural modulus, compression strengths, and compression modulus were comparable with those of composite PMR-15 at both ambient and elevated temperatures (288°C). The second part of the project focussed on isolating the effects of the aromatic triamine from nadic endcap on resins' Tg, TOS, and relative melt viscosity, using a statistical design of experiments (DOE). A pseudo classical design based upon a Face Centered Central Composite Model was used. DOE model generated response surfaces showed that incorporation of the triamine moieties into PMR-type polyimides slightly increased the Tg's of the polymers, due to higher crosslink density, but slightly decreased their thermal oxidative stability. It was also observed that added TAB

  6. 24 CFR 970.13 - Environmental review requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... § 970.27) are subject to HUD environmental regulations in 24 CFR part 58. However, HUD may make a finding in accordance with 24 CFR 58.11(d) of this title and may itself perform the environmental review... the review under 24 CFR part 58. (b) The environmental review is limited to the demolition...

  7. 24 CFR 970.13 - Environmental review requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... § 970.27) are subject to HUD environmental regulations in 24 CFR part 58. However, HUD may make a finding in accordance with 24 CFR 58.11(d) of this title and may itself perform the environmental review... the review under 24 CFR part 58. (b) The environmental review is limited to the demolition...

  8. 24 CFR 970.13 - Environmental review requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... § 970.27) are subject to HUD environmental regulations in 24 CFR part 58. However, HUD may make a finding in accordance with 24 CFR 58.11(d) of this title and may itself perform the environmental review... the review under 24 CFR part 58. (b) The environmental review is limited to the demolition...

  9. 14 CFR 435.23 - Policy review requirements and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Reentry of a Reentry Vehicle § 435.23 Policy review... apply to the policy review conducted for a license to reenter a reentry vehicle under this part....

  10. 14 CFR 435.33 - Safety review requirements and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Safety Review and Approval for Reentry of a Reentry Vehicle § 435.33 Safety review... to the safety review conducted for a license to reenter a reentry vehicle under this part....

  11. 14 CFR 435.23 - Policy review requirements and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Reentry of a Reentry Vehicle § 435.23 Policy review... apply to the policy review conducted for a license to reenter a reentry vehicle under this part....

  12. 14 CFR 435.23 - Policy review requirements and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Reentry of a Reentry Vehicle § 435.23 Policy review... apply to the policy review conducted for a license to reenter a reentry vehicle under this part....

  13. 14 CFR 435.33 - Safety review requirements and procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Safety Review and Approval for Reentry of a Reentry Vehicle § 435.33 Safety review... to the safety review conducted for a license to reenter a reentry vehicle under this part....

  14. 14 CFR 435.23 - Policy review requirements and procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Reentry of a Reentry Vehicle § 435.23 Policy review... apply to the policy review conducted for a license to reenter a reentry vehicle under this part....

  15. 14 CFR 435.33 - Safety review requirements and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Safety Review and Approval for Reentry of a Reentry Vehicle § 435.33 Safety review... to the safety review conducted for a license to reenter a reentry vehicle under this part....

  16. 14 CFR 435.33 - Safety review requirements and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Safety Review and Approval for Reentry of a Reentry Vehicle § 435.33 Safety review... to the safety review conducted for a license to reenter a reentry vehicle under this part....

  17. The evolution of Medicare financing policy for graduate medical education and implications for PM&R: a commentary.

    PubMed

    Verville, R; DeLisa, J A

    2001-04-01

    Currently, the only explicit payers for graduate medical education (GME) in the United States are the federal and state governments. Of these, Medicare is by far the largest and most predictable payer. Through the prospective payment system, Medicare reimburses teaching institutions for both their direct and indirect costs associated with their GME programs. Because a well-educated workforce benefits patients covered by private, as well as public insurance, various proposals have been advanced to establish an all-payer pool to distribute the financial burden more equitably. Furthermore, Medicare policy affects physician supply. There is increasing recognition of potential physician oversupply, raising policy questions about the government's longstanding support of GME. In comparison with other specialties, physical medical and rehabilitation (PM&R) may receive more favorable treatment under future GME funding plans, for 2 reasons. First, under the formulas used by Medicare, PM&R training slots typically bring in more indirect revenue to teaching hospitals than is consumed in indirect expenses. This makes PM&R a relatively more attractive program to retain in the face of mandated reductions in training slots. Second, in many parts of the country, PM&R is not threatened by oversupply, making cuts less likely. Nevertheless, the high percentage of non-US medical graduates entering PM&R training may make the specialty vulnerable to future reductions in funded training slots. PMID:11295022

  18. The effect of elevated temperature on the inelastic deformation behavior of PMR-15 solid polymer

    NASA Astrophysics Data System (ADS)

    Ryther, Chad E. C.

    The inelastic deformation behavior of PMR-15 neat resin, a high-temperature thermoset polymer, was investigated at temperatures in the 274--316 °C range. The experimental program was developed to explore the influence of temperature on strain-controlled tensile loading, relaxation and creep behaviors. The experimental results clearly demonstrate that the mechanical behavior of PMR-15 polymer exhibits a strong dependence on temperature. During strain-controlled tensile loading, the slope of the stress-strain curve in the quasi-elastic region decreases and the slope of the stress-strain curve in the flow stress region increases with increasing temperature. At a given strain rate, the flow stress level decreases with increasing temperature. Furthermore, the transition from quasi-elastic behavior to inelastic flow becomes less pronounced with increasing temperature. During relaxation, the amount of the stress drop for a given prior strain rate decreases with increasing temperature. At a given prior strain rate and creep stress level, increasing temperature results in increased creep strain accumulation. Based on the experimental results the Viscoplasticity Based on Overstress for Polymers (VBOP) theory was augmented to account for the effects of elevated temperature. Several model parameters were determined to depend on temperature. Those parameters were developed into functions of temperature. The augmented VBOP was then employed to predict the response of the PMR-15 polymer under various test histories at temperatures in the 274--316 °C range. An enhanced procedure for determining VBOP model parameters that utilizes a McLean type dip test to assess the equilibrium stress was developed. Model predictions were considerably improved by employing an enhanced model characterization procedure. Additionally, the effects of prior isothermal aging at various temperatures in the 260--316 °C range on the inelastic deformation behavior of PMR-15 at 288 °C were evaluated. For

  19. 42 CFR 456.231 - Continued stay review required.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental Hospitals Ur Plan... a review of each recipient's continued stay in the mental hospital to decide whether it is...

  20. 42 CFR 456.231 - Continued stay review required.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental Hospitals Ur Plan... a review of each recipient's continued stay in the mental hospital to decide whether it is...

  1. Longtime Durability of PMR-15 Matrix Polymer at 204, 260, 288, and 316 C

    NASA Technical Reports Server (NTRS)

    Bowles, Kenneth J.; Papadopoulos, Demetrios S.; Inghram, Linda L.; McCorkle, Linda S.; Klan, Ojars V.

    2001-01-01

    Isothermal weight loss studies at the Glenn (Lewis) Research Center were conducted at four temperatures (204, 260, 288, and 316 C) with specimens of varied geometric shapes to investigate the mechanisms involved in the thermal degradation of PMR-15. Both neat resin behavior and composite behaviors were studied. Two points of interest in these studies are the role(s) of oxygen in the mechanisms involved in the thermo-oxidative degradation of these composite materials and the dimensional changes that occur during their useable lifetime. Specimen dimensional changes and surface layer growth were measured and recorded. It was shown that physical and chemical changes take place as a function of time and location in PMR-15 neat resin and composites as aging takes place in air at elevated temperatures. These changes initiate at the outer surfaces of both materials and progress inward following the oxygen as it proceeds by diffusion into the central core of each material. Microstructural changes cause changes in density, material shrinkage (strains), glass transition temperature, dimension, dynamic shear modulus, and compression properties. These changes also occur slowly dividing the polymer material into two distinct parts: a visibly undamaged core section between two visibly damaged surface layers. The surface layer has a significant effect on compression properties of thinner specimens, but the visibly undamaged core material controls these properties for specimens having eight or more plies. It was demonstrated that there are three different mechanisms involved in the degradation of PMR-15 during aging at elevated temperatures. These are a weight gain, a small weight fraction bulk material weight loss, and a large mass fraction weight loss concentrated at the surface of the polymer or composite. At the higher temperatures (260 C and above), the surface loss predominates. Below 260 C, the surface loss and the bulk core loss become more equivalent. Between 175 and 260 C

  2. 18 CFR 806.5 - Projects that may require review and approval.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Projects that may require review and approval. 806.5 Section 806.5 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION REVIEW AND APPROVAL OF PROJECTS General Provisions § 806.5 Projects that may require review and approval. (a) The...

  3. Thermo-oxidative stability studies of PMR-15 polymer matrix composites reinforced with various fibers

    NASA Technical Reports Server (NTRS)

    Bowles, Kenneth J.

    1990-01-01

    An experimental study was conducted to measure the thermo-oxidative stability of PMR-15 polymer matrix composites reinforced with various fibers and to observe differences in the way they degrade in air. The fibers that were studied included graphite and the thermally stable Nicalon and Nextel ceramic fibers. Weight loss rates for the different composites were assessed as a function of mechanical properties, specimen geometry, fiber sizing, and interfacial bond strength. Differences were observed in rates of weight loss, matrix cracking, geometry dependency, and fiber-sizing effects. It was shown that Celion 6000 fiber-reinforced composites do not exhibit a straight-line Arrhenius relationship at temperatures above 316 C.

  4. Thermo-oxidative stability studies of PMR-15 polymer matrix composites reinforced with various continuous fibers

    NASA Technical Reports Server (NTRS)

    Bowles, Kenneth J.

    1990-01-01

    An experimental study was conducted to measure the thermooxidative stability of PMR-15 composites reinforced with various fibers and to observe differences in the way they degrade in air. The fibers studied include graphite and the thermally stable Nicalon and Nextel ceramic fibers. Weight-loss rates for the different composites were assessed as a function of mechanical properties, specimen geometry, fiber sizing, and interfacial bond strength. Differences were observed in rates of weight loss, matrix cracking, geometry dependency, and fiber sizing effects. It was shown that Celion 6000 fiber-reinforced composites do not exhibit a straight-line Arrhenius relationship at temperatures above 316 C.

  5. Kevlar/PMR-15 polyimide matrix composite for a complex shaped DC-9 drag reduction fairing

    NASA Technical Reports Server (NTRS)

    Kawai, R. T.; Mccarthy, R. F.; Willer, M. S.; Hrach, F. J.

    1982-01-01

    The Aircraft Energy Efficiency (ACEE) Program was established by NASA to improve the fuel efficiency of commercial transport aircraft and thereby to reduce the amount of fuel consumed by the air transportation industry. One of the final items developed by the program is an improved fairing which is the aft closure for the thrust reverser actuators on the JT8D nacelles on DC-9 aircraft. The reduced-drag fairing uses, in the interest of weight savings, an advanced composite construction. The composite material contains Kevlar 49 fibers in a PMR-15 matrix. Attention is given to the aerodynamic configuration, the material system, and aspects of fabrication development.

  6. The pmrCAB Operon Mediates Polymyxin Resistance in Acinetobacter baumannii ATCC 17978 and Clinical Isolates through Phosphoethanolamine Modification of Lipid A▿

    PubMed Central

    Arroyo, Luis A.; Herrera, Carmen M.; Fernandez, Lucia; Hankins, Jessica V.; Trent, M. Stephen; Hancock, Robert E. W.

    2011-01-01

    The emergence of multidrug resistance among Acinetobacter baumannii is leading to an increasing dependence on the use of polymyxins as last-hope antibiotics. Here, we utilized genetic and biochemical methods to define the involvement of the pmrCAB operon in polymyxin resistance in this organism. Sequence analysis of 16 polymyxin B-resistant strains, including 6 spontaneous mutants derived from strain ATCC 17978 and 10 clinical isolates from diverse sources, revealed that they had independent mutations in the pmrB gene, encoding a sensor kinase, or in the response regulator PmrA. Knockout of the pmrB gene in two mutants and two clinical isolates led to a decrease in the polymyxin B susceptibility of these strains, which could be restored with the cloned pmrAB genes from the mutants but not from the wild type. Reverse transcription-quantitative PCR (RT-qPCR) analysis also showed a correlation between the expression of pmrC and polymyxin B resistance. Characterization of lipid A species from the mutant strains, by thin-layer chromatography and mass spectrometry, indicated that the addition of phosphoethanolamine to lipid A correlated with resistance. This addition is performed in Salmonella enterica serovar Typhimurium by the product of the pmrC gene, which is a homolog of the pmrC gene from Acinetobacter. Knockout of this gene in the mutant R2 [pmrB(T235I)] reversed resistance as well as phosphoethanolamine modification of lipid A. These results demonstrate that specific alterations in the sequence of the pmrCAB operon are responsible for resistance to polymyxins in A. baumannii. PMID:21646482

  7. 8 CFR 1214.1 - Review of requirements for admission, extension, and maintenance of status.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS REVIEW OF NONIMMIGRANT CLASSES § 1214.1... nonimmigrant status and departure from the United States, if required to do so by the director, immigration judge or Board of Immigration Appeals....

  8. 40 CFR 1502.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....), the Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), and other environmental review laws and executive orders. (b) The draft environmental impact statement shall list all Federal permits, licenses,...

  9. 40 CFR 1502.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....), the Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), and other environmental review laws and executive orders. (b) The draft environmental impact statement shall list all Federal permits, licenses,...

  10. 40 CFR 1502.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....), the Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), and other environmental review laws and executive orders. (b) The draft environmental impact statement shall list all Federal permits, licenses,...

  11. 40 CFR 1502.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....), the Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), and other environmental review laws and executive orders. (b) The draft environmental impact statement shall list all Federal permits, licenses,...

  12. Viscoelastic and Mechanical Properties of Thermoset PMR-type Polyimide-Clay Nanocomposites

    NASA Technical Reports Server (NTRS)

    Abdalla, Mohamed O.; Dean, Derrick; Campbell, Sandi

    2002-01-01

    High temperature thermoset polyimide-clay nanocomposites were prepared by blending 2.5 and 5 wt% of an unmodified Na(+-) montmorillonite (PGV) and two organically modified FGV (PGVCl0COOH, PGVC12) with a methanol solution of PMR-15 precursor. The methanol facilitated the dispersal of the unmodified clay. Dynamic mechanical analysis results showed a significant increase in the thermomechanical properties (E' and E") of 2.5 wt% clay loaded nanocomposites in comparison with the neat polyimide. Higher glass transition temperatures were observed for 2.5 wt% nanocomposites compared to the neat polyimide. Flexural properties measurements for the 2.5 wt% nanocomposites showed a significant improvement in the modulus and strength, with no loss in elongation. This trend was not observed for the 5 wt% nanocomposites. An improvement in the CTE was observed for the PGV/PMR-15 nanocomposites, while a decrease was observed for the organically modified samples. This was attributed to potential variations in the interface caused by modifier degradation.

  13. Electron Paramagnetic Resonance Imaging of the Spatial Distribution of Free Radicals in PMR-15 Polyimide Resins

    NASA Technical Reports Server (NTRS)

    Ahn, Myong K.; Eaton, Sandra S.; Eaton, Gareth R.; Meador, Mary Ann B.

    1997-01-01

    Prior studies have shown that free radicals generated by heating polyimides above 300 C are stable at room temperature and are involved in thermo-oxidative degradation in the presence of oxygen gas. Electron paramagnetic resonance imaging (EPRI) is a technique to determine the spatial distribution of free radicals. X-band (9.5 GHz) EPR images of PMR-15 polyimide were obtained with a spatial resolution of approximately 0.18 mm along a 2-mm dimension of the sample. In a polyimide sample that was not thermocycled, the radical distribution was uniform along the 2-mm dimension of the sample. For a polyimide sample that was exposed to thermocycling in air for 300 1-h cycles at 335 C, one-dimensional EPRI showed a higher concentration of free radicals in the surface layers than in the bulk sample. A spectral-spatial two-dimensional image showed that the EPR lineshape of the surface layer remained the same as that of the bulk. These EPRI results suggest that the thermo-oxidative degradation of PMR-15 resin involves free radicals present in the oxygen-rich surface layer.

  14. Electron Paramagnetic Resonance Imaging of the Spatial Distribution of Free Radicals in PMR-15 Polyimide Resins

    NASA Technical Reports Server (NTRS)

    Ahn, Myong K.; Eaton, Sandra S.; Eaton, Gareth R.; Meador, Mary Ann B.

    1997-01-01

    Prior studies have shown that free radicals generated by heating polyimides above 300 C are stable at room temperature and are involved in thermo-oxidative degradation in the presence of oxygen gas. Electron Paramagnetic Resonance Imaging (EPRI) is a technique to determine the spatial distribution of free radicals. X-band (9.5 GHz) EPR images of PMR-15 polyimide were obtained with a spatial resolution of about 0.18 mm along a 2 mm dimension of the sample. In a polyimide sample that was not thermocycled, the radical distribution was uniform along the 2 mm dimension of the sample. For a polyimide sample that was exposed to thermocycling in air for 300 one-hour cycles at 335 C, one-dimensional EPRI showed a higher concentration of free radicals in the surface layers than in the bulk sample. A spectral-spatial two-dimensional image showed that the EPR lineshape of the surface layer remained the same as that of the bulk. These EPRI results suggest that the thermo-oxidative degradation of PMR-15 resin involves free radicals present in the oxygen-rich surface layer.

  15. 76 FR 76359 - Notice of Public Information Collection Requirements Submitted to OMB for Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ...; ] AGENCY FOR INTERNATIONAL DEVELOPMENT Notice of Public Information Collection Requirements Submitted to OMB for Review SUMMARY: U.S. Agency for International Development (USAID) has submitted the...

  16. 14 CFR 431.57 - Information requirements for payload reentry review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review and Determination § 431.57 Information requirements for...

  17. 14 CFR 431.57 - Information requirements for payload reentry review.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review and Determination § 431.57 Information requirements for...

  18. 14 CFR 431.57 - Information requirements for payload reentry review.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review and Determination § 431.57 Information requirements for...

  19. 14 CFR 431.57 - Information requirements for payload reentry review.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review and Determination § 431.57 Information requirements for...

  20. 10 CFR 1040.4 - Assurances required and preaward review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... from academic and other institutions. (1) In the case of any application for Federal financial assistance for any purpose to an academic institution, the assurance required by this section is to extend to... required with respect to an academic institution, detention or correctional facility, or any...

  1. 33 CFR 230.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... study potential impacts. Depending on expected extent and severity of impacts, or if entry is deemed... consultation requirements. See 40 CFR 1502.25. (a) For Federal projects, NEPA documents shall be prepared..., 1979, 32 CFR part 197. Procedural requirements for Civil Works studies and projects are discussed...

  2. 33 CFR 230.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... study potential impacts. Depending on expected extent and severity of impacts, or if entry is deemed... consultation requirements. See 40 CFR 1502.25. (a) For Federal projects, NEPA documents shall be prepared..., 1979, 32 CFR part 197. Procedural requirements for Civil Works studies and projects are discussed...

  3. Preparation, review, and approval of implementation plans for nuclear safety requirements

    SciTech Connect

    Not Available

    1994-10-01

    This standard describes an acceptable method to prepare, review, and approve implementation plans for DOE Nuclear Safety requirements. DOE requirements are identified in DOE Rules, Orders, Notices, Immediate Action Directives, and Manuals.

  4. 24 CFR 970.13 - Environmental review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... § 970.27) are subject to HUD environmental regulations in 24 CFR part 58. However, HUD may make a finding in accordance with 24 CFR 58.11(d) of this title and may itself perform the environmental review under the provisions of 24 CFR part 50 if a PHA objects in writing to the responsible entity...

  5. 48 CFR 801.602-75 - Review requirements-OGC.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... legal review or concurrence from OGC for the following categories of proposed contractual actions. (1... modification for which the contractor takes exception to the accord and satisfaction language specified by VA... until the contracting officer receives OGC's concurrence in the proposed language. (7) An assignment...

  6. 24 CFR 970.13 - Environmental review requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... § 970.27) are subject to HUD environmental regulations in 24 CFR part 58. However, HUD may make a finding in accordance with 24 CFR 58.11(d) of this title and may itself perform the environmental review under the provisions of 24 CFR part 50 if a PHA objects in writing to the responsible entity...

  7. 7 CFR 1980.453 - Review of requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... after receiving a conditional commitment that it no longer wants a Loan Note Guarantee, the lender will... or its successor agency under Public Law 103-354 State Loan Review Board Minutes. 4. Notification of... Director. If certain conditions cannot be met, the lender and borrower may propose alternate conditions...

  8. 21 CFR 814.124 - Institutional Review Board requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.124...) constituted and acting pursuant to part 56 of this chapter, including continuing review of use of the device.... In such an emergency situation, the physician shall, within 5 days after the use of the...

  9. 21 CFR 814.124 - Institutional Review Board requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.124...) constituted and acting pursuant to part 56 of this chapter, including continuing review of use of the device.... In such an emergency situation, the physician shall, within 5 days after the use of the...

  10. 14 CFR 431.25 - Application requirements for policy review.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Launch and Reentry of a Reusable Launch Vehicle § 431.25 Application... model, type, and configuration of any RLV proposed for launch and reentry, or otherwise landing on...

  11. 14 CFR 431.25 - Application requirements for policy review.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Launch and Reentry of a Reusable Launch Vehicle § 431.25 Application... model, type, and configuration of any RLV proposed for launch and reentry, or otherwise landing on...

  12. 14 CFR 431.25 - Application requirements for policy review.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Launch and Reentry of a Reusable Launch Vehicle § 431.25 Application... model, type, and configuration of any RLV proposed for launch and reentry, or otherwise landing on...

  13. 14 CFR 431.25 - Application requirements for policy review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Launch and Reentry of a Reusable Launch Vehicle § 431.25 Application..., by the applicant. (b) Identify all vehicle systems, including structural, thermal,...

  14. 21 CFR 814.124 - Institutional Review Board requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.124...) constituted and acting pursuant to part 56 of this chapter, including continuing review of use of the device.... In such an emergency situation, the physician shall, within 5 days after the use of the...

  15. 21 CFR 814.124 - Institutional Review Board requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.124...) constituted and acting pursuant to part 56 of this chapter, including continuing review of use of the device.... In such an emergency situation, the physician shall, within 5 days after the use of the...

  16. 21 CFR 814.124 - Institutional Review Board requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.124...) constituted and acting pursuant to part 56 of this chapter, including continuing review of use of the device.... In such an emergency situation, the physician shall, within 5 days after the use of the...

  17. Review of the mechanical design requirements for offshore pedestal cranes

    SciTech Connect

    Alexander, P.E.; Wong, W.

    1984-02-01

    Modern design philosophies for offshore cranes require the structural components to be designed for the dynamic loadings experienced in the offshore environment. If these predicted impact loads are applied to the relevant winch load-paths, then the components in those load-paths can be appropriately designed. Specifications do not at present, require the operator to predict at the enquiry stage, the service duty and load spectrums for the crane. When these are specified by the operator, the designer is able to apply appropriate stress levels to the components to attain the required crane life.

  18. Quiet Clean Short-Haul Experimental Engine (QCSEE) Under-The-Wing (UTW) graphite/PMR cowl development

    NASA Technical Reports Server (NTRS)

    Ruggles, C. L.

    1978-01-01

    The PMR process development, tooling concepts, testing conducted to generate materials properties data, and the fabrication of a subscale model of the inner cowl are presented. It was concluded that the materials, processes, and tooling concepts were satisfactory for making an inner cowl with adequate structural integrity.

  19. Structure and dynamics of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA

    PubMed Central

    Lou, Yuan-Chao; Weng, Tsai-Hsuan; Li, Yi-Chuan; Kao, Yi-Fen; Lin, Wei-Feng; Peng, Hwei-Ling; Chou, Shan-Ho; Hsiao, Chwan-Deng; Chen, Chinpan

    2015-01-01

    PmrA, an OmpR/PhoB family response regulator, manages genes for antibiotic resistance. Phosphorylation of OmpR/PhoB response regulator induces the formation of a symmetric dimer in the N-terminal receiver domain (REC), promoting two C-terminal DNA-binding domains (DBDs) to recognize promoter DNA to elicit adaptive responses. Recently, determination of the KdpE–DNA complex structure revealed an REC–DBD interface in the upstream protomer that may be necessary for transcription activation. Here, we report the 3.2-Å-resolution crystal structure of the PmrA–DNA complex, which reveals a similar yet different REC–DBD interface. However, NMR studies show that in the DNA-bound state, two domains tumble separately and an REC–DBD interaction is transiently populated in solution. Reporter gene analyses of PmrA variants with altered interface residues suggest that the interface is not crucial for supporting gene expression. We propose that REC–DBD interdomain dynamics and the DBD–DBD interface help PmrA interact with RNA polymerase holoenzyme to activate downstream gene transcription. PMID:26564787

  20. Fabrication and characterization of nanoclay modified PMR type polyimide composites reinforced with 3D woven basalt fabric

    NASA Astrophysics Data System (ADS)

    Xie, Jianfei; Qiu, Yiping

    2009-07-01

    Nanoclay modified PMR type polyimide composites were prepared from 3D orthogonal woven basalt fiber performs and nanoclay modified polyimide matrix resin, which derived from methylene dianiline (MDA), dimethyl ester of 3,3',4,4'- oxydiphthalic acid (ODPE), monomethyl ester of cis-5-norbornene-endo-2,3-dicarboxylic acid (NE) and nanoclay. The Na+-montmorillonite was organically treated using a 1:1 molar ratio mixture of dodecylamine (C12) and MDA. The rheological properties of neat B-stage PMR polyimide and 2% clay modified B-stage PMR polyimide were investigated. Based on the results obtained from the rheological tests, a two step compression molding process can be established for the composites. In the first step, the 3D fabric preforms were impregnated with polyimide resin in a vacuum oven and heated up for degassing the volatiles and by-products. In the second step, composites were compressed. The internal structure of the composites was observed by a microscope. Incorporation of 2% clay showed an improvement in the Tg and stiffness of the PMR polyimide. The resulting composites exhibited high thermal stability and good mechanical properties.

  1. Differential Role of Two-Component Regulatory Systems (phoPQ and pmrAB) in Polymyxin B Susceptibility of Pseudomonas aeruginosa

    PubMed Central

    Owusu-Anim, Daniel; Kwon, Dong H.

    2013-01-01

    Polymyxins are often considered as a last resort to treat multidrug resistant P. aeruginosa but polymyxin resistance has been increasingly reported worldwide in clinical isolates. Polymyxin resistance in P. aeruginosa is known to be associated with alterations in either PhoQ or PmrB. In this study, mutant strains of P. aeruginosa carrying amino acid substitution, a single and/or dual inactivation of PhoQ and PmrB were constructed to further understand the roles of PhoQ and PmrB in polymyxin susceptibility. Polymyxin B resistance was caused by both inactivation and/or amino acid substitutions in PhoQ but by only amino acid substitutions of PmrB. Alterations of both PhoQ and PmrB resulted in higher levels of polymyxin B resistance than alteration of either PhoQ or PmrB alone. These results were confirmed by time-killing assays suggesting that high-level polymyxin resistance in P. aeruginosa is caused by alterations of both PhoQ and PmrB. PMID:24349887

  2. Literature Review and Annotated Bibliography: Water Requirements of Desert Ungulates

    USGS Publications Warehouse

    Cain, James W.; Krausman, Paul R.; Rosenstock, Steven S.; Turner, Jack C.

    2005-01-01

    Executive Summary Ungulates adapted to desert areas are able to survive extreme temperatures and limited water availability. This ability is largely due to behavioral, morphological, and physiological adaptations that allow these animals to avoid or tolerate extreme environmental conditions. The physiological adaptations possessed by ungulates for thermoregulation and maintenance of water balance have been the subject of numerous studies involving a wide range of species. In this report we review the behavioral, morphological, and physiological mechanisms used by ungulates and other desert mammals to maintain water and temperature balance in arid environments. We also review some of the more commonly used methods for studying the physiological mechanisms involved in water balance and thermoregulation, and the influence of dehydration on these mechanisms.

  3. 41 CFR 102-75.145 - Is GSA required to review each report of excess?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... review each report of excess? 102-75.145 Section 102-75.145 Public Contracts and Property Management...-REAL PROPERTY DISPOSAL Utilization of Excess Real Property Examination for Acceptability § 102-75.145 Is GSA required to review each report of excess? Yes, GSA must review each report of excess...

  4. 41 CFR 102-75.145 - Is GSA required to review each report of excess?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... review each report of excess? 102-75.145 Section 102-75.145 Public Contracts and Property Management...-REAL PROPERTY DISPOSAL Utilization of Excess Real Property Examination for Acceptability § 102-75.145 Is GSA required to review each report of excess? Yes, GSA must review each report of excess...

  5. 41 CFR 102-75.145 - Is GSA required to review each report of excess?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... review each report of excess? 102-75.145 Section 102-75.145 Public Contracts and Property Management...-REAL PROPERTY DISPOSAL Utilization of Excess Real Property Examination for Acceptability § 102-75.145 Is GSA required to review each report of excess? Yes, GSA must review each report of excess...

  6. 41 CFR 102-75.145 - Is GSA required to review each report of excess?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... review each report of excess? 102-75.145 Section 102-75.145 Public Contracts and Property Management...-REAL PROPERTY DISPOSAL Utilization of Excess Real Property Examination for Acceptability § 102-75.145 Is GSA required to review each report of excess? Yes, GSA must review each report of excess...

  7. 41 CFR 102-75.145 - Is GSA required to review each report of excess?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... review each report of excess? 102-75.145 Section 102-75.145 Public Contracts and Property Management...-REAL PROPERTY DISPOSAL Utilization of Excess Real Property Examination for Acceptability § 102-75.145 Is GSA required to review each report of excess? Yes, GSA must review each report of excess...

  8. 42 CFR 476.74 - General requirements for the assumption of review.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false General requirements for the assumption of review. 476.74 Section 476.74 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS UTILIZATION AND QUALITY CONTROL REVIEW Review Responsibilities of Utilization...

  9. 42 CFR 476.74 - General requirements for the assumption of review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false General requirements for the assumption of review. 476.74 Section 476.74 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS UTILIZATION AND QUALITY CONTROL REVIEW Review Responsibilities of Utilization...

  10. 14 CFR 435.43 - Payload reentry review requirements and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review and Determination § 435.43 Payload reentry review requirements and... shall apply to the payload reentry review conducted for a license to reenter a reentry vehicle...

  11. 14 CFR 435.43 - Payload reentry review requirements and procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review and Determination § 435.43 Payload reentry review requirements and... shall apply to the payload reentry review conducted for a license to reenter a reentry vehicle...

  12. 14 CFR 435.43 - Payload reentry review requirements and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review and Determination § 435.43 Payload reentry review requirements and... shall apply to the payload reentry review conducted for a license to reenter a reentry vehicle...

  13. 14 CFR 435.43 - Payload reentry review requirements and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review and Determination § 435.43 Payload reentry review requirements and... shall apply to the payload reentry review conducted for a license to reenter a reentry vehicle...

  14. Advances in the study on nutrient requirements of grouper (Epinephelus sp.): a review

    NASA Astrophysics Data System (ADS)

    Luo, Zhi; Liu, Yongjian; Mai, Kangsen; Tian, Lixia

    2005-04-01

    The paper reviews the recent advances in studying grouper nutrition requirement for the development of cost-effective and environmentally friendly artificial diets. It consists of seven parts: protein and amino acid, lipid and essential fatty acid, carbohydrate, vitamin, mineral, alternative protein source, broodstock and larval nutrition. The review provides some basic information for further investigation of nutrient requirements of groupers.

  15. 10 CFR 1021.341 - Coordination with other environmental review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... environmental review requirements. (a) In accordance with 40 CFR 1500.4(k) and (o), 1502.25, and 1506.4, DOE... 10 Energy 4 2010-01-01 2010-01-01 false Coordination with other environmental review requirements. 1021.341 Section 1021.341 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NATIONAL...

  16. 25 CFR 1000.365 - What are the requirements of the review team report?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What are the requirements of the review team report? 1000.365 Section 1000.365 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE... requirements of the review team report? A report summarizing the results of the trust evaluation will...

  17. 40 CFR 6.201 - Coordination with other environmental review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Coordination with other environmental review requirements. 6.201 Section 6.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... environmental review requirements. Consistent with 40 CFR 1500.5(g) and 1502.25, the Responsible Official...

  18. 40 CFR 6.201 - Coordination with other environmental review requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Coordination with other environmental review requirements. 6.201 Section 6.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... environmental review requirements. Consistent with 40 CFR 1500.5(g) and 1502.25, the Responsible Official...

  19. 40 CFR 51.1011 - Requirements for mid-course review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 2 2012-07-01 2012-07-01 false Requirements for mid-course review. 51.1011 Section 51.1011 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... PM2.5 National Ambient Air Quality Standards § 51.1011 Requirements for mid-course review. (a)...

  20. A Public Review in Federal Region VI of the Federal Interagency Day Care Requirements.

    ERIC Educational Resources Information Center

    Office of Human Development (DHEW), Dallas, TX. Region 6.

    The basic objective of this investigation was to conduct an input-review of the 1968, 1972 and Title XX Federal Interagency Day Care Requirements (FIDCR) and to make inferences gleaned from the results as these relate to appropriate revisions. Respondents from a number of states were asked to review and comment on each requirement. The document…

  1. Secretory expression and purification of Aspergillus niger glucose oxidase in Saccharomyces cerevisiae mutant deficient in PMR1 gene.

    PubMed

    Ko, Ji-Hyun; Hahm, Moon Sun; Kang, Hyun Ah; Nam, Soo Wan; Chung, Bong Hyun

    2002-08-01

    The gene encoding glucose oxidase (GOD) from Aspergillus niger was expressed as a secretory product in the yeast Saccharomyces cerevisiae. Six consecutive histidine residues were fused to the C-terminus of GOD to facilitate purification. The recombinant GOD-His(6) secreted by S. cerevisiae migrated as a broad diffuse band on SDS-PAGE, with an apparent molecular weight higher than that in natural A. niger GOD. To investigate the effects of hyperglycosylation on the secretion efficiency and enzyme properties, GOD-His(6) was expressed and secreted in a S. cerevisiae mutant in which the PMR1 gene encoding Ca(++)-ATPase was disrupted. The pmr1 null mutant strain secreted an amount of GOD-His(6) per unit cell mass higher than that in the wild-type strain. In contrast to the hyperglycosylated GOD-His(6) secreted in the wild-type strain, the pmr1 mutant strain secreted GOD-His(6) in a homogeneous form with a protein band pattern similar to that in natural A. niger GOD, based on SDS-PAGE. The hyperglycosylated and pmr1Delta mutant-derived GOD-His(6) enzymes were purified to homogeneity by immobilized metal ion-affinity chromatography and their specific activities and stabilities were compared. The specific activity of the pmr1Delta mutant-derived GOD-His(6) on a protein basis was very similar to that of the hyperglycosylated GOD-His(6), although its pH and thermal stabilities were lower than those of the hyperglycosylated GOD-His(6). PMID:12182830

  2. 14 CFR 1216.320 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Executive Order 11990 (Wetlands), as amended, and implemented by 14 CFR subpart 1216.2—Floodplains and... and regulations listed below: (1) Section 106 of the National Historic Preservation Act of 1966 (16 U.S.C. 470(f)) requires identification of National Register properties, eligible properties,...

  3. 14 CFR 1216.320 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Executive Order 11990 (Wetlands), as amended, and implemented by 14 CFR subpart 1216.2—Floodplains and... and regulations listed below: (1) Section 106 of the National Historic Preservation Act of 1966 (16 U.S.C. 470(f)) requires identification of National Register properties, eligible properties,...

  4. 14 CFR 1216.320 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Executive Order 11990 (Wetlands), as amended, and implemented by 14 CFR subpart 1216.2—Floodplains and... and regulations listed below: (1) Section 106 of the National Historic Preservation Act of 1966 (16 U.S.C. 470(f)) requires identification of National Register properties, eligible properties,...

  5. 40 CFR 6.403 - Environmental review and assessment requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... section 102(c) of the MPRSA and 40 CFR part 228, and for the establishment or revision of criteria under... environmental assessment shall be made by EPA. Pursuant to 40 CFR part 221, the permit applicant shall submit... submitted under 40 CFR part 221 shall be sufficient to satisfy the environmental assessment requirement....

  6. 40 CFR 6.403 - Environmental review and assessment requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... environmental assessment shall be made by EPA. Pursuant to 40 CFR part 221, the permit applicant shall submit... submitted under 40 CFR part 221 shall be sufficient to satisfy the environmental assessment requirement. (c... Significant Deterioration (PSD) regulations (40 CFR part 52) shall satisfy the environmental...

  7. 40 CFR 6.403 - Environmental review and assessment requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... environmental assessment shall be made by EPA. Pursuant to 40 CFR part 221, the permit applicant shall submit... submitted under 40 CFR part 221 shall be sufficient to satisfy the environmental assessment requirement. (c... Significant Deterioration (PSD) regulations (40 CFR part 52) shall satisfy the environmental...

  8. 40 CFR 6.403 - Environmental review and assessment requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... environmental assessment shall be made by EPA. Pursuant to 40 CFR part 221, the permit applicant shall submit... submitted under 40 CFR part 221 shall be sufficient to satisfy the environmental assessment requirement. (c... Significant Deterioration (PSD) regulations (40 CFR part 52) shall satisfy the environmental...

  9. 40 CFR 6.403 - Environmental review and assessment requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... environmental assessment shall be made by EPA. Pursuant to 40 CFR part 221, the permit applicant shall submit... submitted under 40 CFR part 221 shall be sufficient to satisfy the environmental assessment requirement. (c... Significant Deterioration (PSD) regulations (40 CFR part 52) shall satisfy the environmental...

  10. 22 CFR 161.11 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., and environmental impact statements. The principal additional requirements affecting the Department of... in draft environmental impact statements and transmitted to the Advisory Council on Historic... discussed in draft environmental impact statements and transmitted to the U.S. Water Resources Council...

  11. Free and Compulsory School Age Requirements. ECS 50-State Reviews

    ERIC Educational Resources Information Center

    Aragon, Stephanie

    2015-01-01

    Policymakers across the nation continue to push for expanded free and compulsory school age requirements. More states are considering granting students earlier access to a free education so that they can begin their academic pursuits earlier in life. Similarly, every year a number of states consider extending the upper limit for compulsory school…

  12. High temperature, short term tensile strength of C6000/PMR-15 composites

    NASA Technical Reports Server (NTRS)

    Digiovanni, P. R.; Paterson, D.

    1985-01-01

    Tensile tests were conducted on 0 unidirectionally reinforced Celion 6000 graphite fibers in PMR-15 polyimide matrix. Tensile strengths for coupons subjected to short and long term uniform temperatures were obtained. Thick coupons, heated on one side to produce significant transient through thickness temperature gradients, were tested and compared to the strength of specimens with uniform temperature distributions. All coupons were radiantly heated and reached maximum test temperatures within 15 sec. Tensile loads were applied to the coupons after 15 sec of elevated temperature exposure. Loading rates were selected so that specimen failures occurred within a maximum of 45 sec after reaching the test temperature. Results indicate that significant tensile strength remains beyond the material post cure temperature.

  13. Intelligent sensor-model automated control of PMR-15 autoclave processing

    NASA Technical Reports Server (NTRS)

    Hart, S.; Kranbuehl, D.; Loos, A.; Hinds, B.; Koury, J.

    1992-01-01

    An intelligent sensor model system has been built and used for automated control of the PMR-15 cure process in the autoclave. The system uses frequency-dependent FM sensing (FDEMS), the Loos processing model, and the Air Force QPAL intelligent software shell. The Loos model is used to predict and optimize the cure process including the time-temperature dependence of the extent of reaction, flow, and part consolidation. The FDEMS sensing system in turn monitors, in situ, the removal of solvent, changes in the viscosity, reaction advancement and cure completion in the mold continuously throughout the processing cycle. The sensor information is compared with the optimum processing conditions from the model. The QPAL composite cure control system allows comparison of the sensor monitoring with the model predictions to be broken down into a series of discrete steps and provides a language for making decisions on what to do next regarding time-temperature and pressure.

  14. Intelligent sensor-model automated control of PMR-15 autoclave processing

    NASA Astrophysics Data System (ADS)

    Hart, S.; Kranbuehl, D.; Loos, A.; Hinds, B.; Koury, J.

    An intelligent sensor model system has been built and used for automated control of the PMR-15 cure process in the autoclave. The system uses frequency-dependent FM sensing (FDEMS), the Loos processing model, and the Air Force QPAL intelligent software shell. The Loos model is used to predict and optimize the cure process including the time-temperature dependence of the extent of reaction, flow, and part consolidation. The FDEMS sensing system in turn monitors, in situ, the removal of solvent, changes in the viscosity, reaction advancement and cure completion in the mold continuously throughout the processing cycle. The sensor information is compared with the optimum processing conditions from the model. The QPAL composite cure control system allows comparison of the sensor monitoring with the model predictions to be broken down into a series of discrete steps and provides a language for making decisions on what to do next regarding time-temperature and pressure.

  15. Thermo-oxidative stability of graphite fiber/PMR-15 polyimide composites at 350 deg C

    NASA Technical Reports Server (NTRS)

    Scola, D. A.

    1985-01-01

    A series of graphite fiber/PMR-15 polyimide composites were subjected to isothermal aging at 350 C in flowing air (100 cc/min and 1000 cc/min) over a 520 hr time period. The graphite fibers were analyzed by ISS/SIMS techniques before composite fabrication. Fibers exposed at the surface of the composite due to the isothermal aging process were also analyzed by the ISS/SIMS method. Component and composite weight less studies were also conducted for similarly exposed materials. Optical micrograph investigations of composites to follow the progress of the thermo-oxidative process were also conducted. Flexural and interlaminar shear strengths of the imaged and aged composites were measured. The relationship of component and composite properties as they relate to the thermo-oxidative behavior of the materials was discussed.

  16. Test and analysis of Celion 3000/PMR-15, graphite/polyimide bonded composite joints: Data report

    NASA Technical Reports Server (NTRS)

    Cushman, J. B.; Mccleskey, S. F.; Ward, S. H.

    1982-01-01

    Standard single lap, double lap and symmetric step lap bonded joints of Celion 3000/PMR-15 graphite/polyimide composite were evaluated. Composite to composite and composite to titanium joints were tested at 116 K (-250 F), 294 K (70 F) and 561 K (550 F). Joint parameters evaluated are lap length, adherend thickness, adherend axial stiffness, lamina stacking sequence and adherend tapering. Advanced joint concepts were examined to establish the change in performance of preformed adherends, scalloped adherends and hybrid systems. The material properties of the high temperature adhesive, designated A7F, used for bonding were established. The bonded joint tests resulted in interlaminar shear or peel failures of the composite and there were very few adhesive failures. Average test results agree with expected performance trends for the various test parameters. Results of finite element analyses and of test/analysis correlations are also presented.

  17. Test and analysis of Celion 3000/PMR-15, graphite/polyimide bonded composite joints: Summary

    NASA Technical Reports Server (NTRS)

    Cushman, J. B.; Mccleskey, S. F.; Ward, S. H.

    1983-01-01

    Standard single lap, double lap and symmetric step lap bonded joints of Celion 3000/PMR-15 graphite/polyimide composite were evaluated. Composite to composite and composite to titanium joints were tested at 116K (-250 F), 294K (70 F) and 561K (550 F). Joint parameters evaluated were lap length, adherend thickness, adherend axial stiffness, lamina stacking sequence and adherend tapering. Tests of advanced joint concepts were also conducted to establish the change in performance of preformed adherends, scalloped adherends and hybrid systems. Special tests were conducted to establish material properties of the high temperature adhesive, designated A7F, used for bonding. Most of the bonded joint tests resulted in interlaminar shear or peel failures of the composite. There were very few adhesive failures. Average test results agree with expected performance trends for the various test parameters. Results of finite element analyses and of test/analysis correlations are also presented.

  18. Spacecraft occupant protection requirements: a review of the recent changes.

    PubMed

    Somers, Jeffrey T; Gohmert, Dustin M; Brinkley, James W

    2014-09-01

    NASA has recently updated spacecraft design requirements for protecting crewmembers during dynamic spaceflight phases. The details of the update are available in a NASA publication (NASA TM-2013-217380) and are summarized here. Previously, NASA's occupant protection requirements relied primarily on the multiaxial dynamic response criterion, which NASA refers to as the Brinkley Dynamic Response Criteria (BDRC). Although simple to implement, there are several important ground rules that must be met for the injury predictions to be applicable. These include proper restraint, flail controls, proper seating support, pressure suit considerations, head protection including consideration of helmet mass, and spaceflight deconditioning. Even if these ground rules are met, there are limitations to the model that must be addressed, including: model validation, sex differences, age effects, anthropometry effects, and differences between the physical fitness of military test subjects and future crewmembers. To address these limitations, new injury assessment reference values (IARV) have been prescribed for the 5(th) percentile female and 95(th) percentile male Hybrid III anthropomorphic test devices (ATD). These metrics are head-injury criterion, head-rotational acceleration, neck injury criterion, neck-axial-force limits, flail prevention, and lumbar-axial compression force. Using these new ATD IARVs, NASA can have increased confidence that vehicle designs mitigate the risk of injury during dynamic phases of flight. PMID:25197893

  19. 78 FR 25445 - Federal Acquisition Regulation; Submission for OMB Review; Quality Assurance Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... information collection requirement concerning quality assurance requirements. A notice was published in the Federal Register at 77 FR 67366, on November 11, 2012. No comments were received. DATES: Submit comments... Regulation; Submission for OMB Review; Quality Assurance Requirements AGENCY: Department of Defense...

  20. Review of PREPA Technical Requirements for Interconnecting Wind and Solar Generation

    SciTech Connect

    Gevorgian, Vahan; Booth, Sarah

    2013-11-01

    The Puerto Rico Electric Power Authority developed the minimum technical requirements for interconnection of wind turbine generation and photovoltaic power plants. NREL has conducted a review of these requirements based on generic technical aspects and electrical characteristics of wind and photovoltaic power plants, and on existing requirements from other utilities (both U.S. and European).

  1. 77 FR 62495 - Federal Acquisition Regulation; Submission for OMB Review; Novation/Change of Name Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... approved information collection requirement concerning Novation/Change of Name Requirements. A notice was published in the Federal Register at 77 FR 29983, on May 21, 2012. One respondent submitted comments. Public... Regulation; Submission for OMB Review; Novation/Change of Name Requirements AGENCY: Department of...

  2. Review of power requirements for satellite remote sensing systems

    NASA Technical Reports Server (NTRS)

    Morain, Stanley A.

    1988-01-01

    The space environment offers a multitude of attributes and opportunities to be used to enhance human life styles and qualities of life for all future generations, worldwide. Among the prospects having immense social as well as economic benefits are earth-observing systems capable of providing near real-time data in such areas as food and fiber production, marine fisheries, ecosystem monitoring, disaster assessment, and global environmental exchanges. The era of Space Station, the Shuttle program, the planned unmanned satellites in both high and low Earth orbit will transfer to operational status what, until now, has been largely research and development proof of concept for remotely sensing Earth's natural and cultural resources. An important aspect of this operational status focuses on the orbital designs and power requirements needed to optimally sense any of these important areas.

  3. 42 CFR 475.104 - Requirements for demonstrating ability to perform review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS QUALITY IMPROVEMENT ORGANIZATIONS Utilization and Quality Control Quality Improvement Organizations § 475.104 Requirements for demonstrating... performance objectives and perform the utilization and quality review functions established under section...

  4. 48 CFR 215.407-5-70 - Disclosure, maintenance, and review requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... management systems (e.g., production control or cost accounting) with the estimating system so that the... of appropriate analytical methods; (xi) Integrates information available from other management systems, where appropriate; (xii) Requires management review including verification that the...

  5. 42 CFR 475.104 - Requirements for demonstrating ability to perform review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS QUALITY IMPROVEMENT ORGANIZATIONS Utilization and Quality Control Quality Improvement Organizations § 475.104 Requirements for demonstrating... performance objectives and perform the utilization and quality review functions established under section...

  6. 78 FR 13855 - Notice of Public Information Collection Requirements Submitted to OMB for Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-01

    ... FOR INTERNATIONAL DEVELOPMENT Notice of Public Information Collection Requirements Submitted to OMB for Review SUMMARY: U.S. Agency for International Development (USAID) has submitted the following... Submission: New Information Collection. Purpose: United States Agency for International Development...

  7. 78 FR 17181 - Notice of Public Information Collection Requirements Submitted to OMB for Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ...; ] AGENCY FOR INTERNATIONAL DEVELOPMENT Notice of Public Information Collection Requirements Submitted to OMB for Review SUMMARY: U.S. Agency for International Development (USAID) has submitted the following...: Inquiry for Employment, Residence, Personal, Education and Law. Type of Submission: Reinstatement...

  8. 40 CFR 148.22 - Requirements for petition submission, review and approval or denial.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., review and approval or denial. 148.22 Section 148.22 Protection of Environment ENVIRONMENTAL PROTECTION... and Procedures § 148.22 Requirements for petition submission, review and approval or denial. (a) Any... demonstration will be made; (2) A waste analysis to describe fully the chemical and physical characteristics...

  9. 40 CFR 148.22 - Requirements for petition submission, review and approval or denial.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., review and approval or denial. 148.22 Section 148.22 Protection of Environment ENVIRONMENTAL PROTECTION... and Procedures § 148.22 Requirements for petition submission, review and approval or denial. (a) Any... demonstration will be made; (2) A waste analysis to describe fully the chemical and physical characteristics...

  10. 12 CFR 550.220 - Are any other account reviews required?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Are any other account reviews required? 550.220 Section 550.220 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY FIDUCIARY POWERS OF SAVINGS ASSOCIATIONS Exercising Fiduciary Powers Review of A Fiduciary Account § 550.220...

  11. 12 CFR 550.220 - Are any other account reviews required?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Are any other account reviews required? 550.220 Section 550.220 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY FIDUCIARY POWERS OF SAVINGS ASSOCIATIONS Exercising Fiduciary Powers Review of A Fiduciary Account § 550.220...

  12. 14 CFR 431.57 - Information requirements for payload reentry review.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Information requirements for payload reentry review. 431.57 Section 431.57 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review...

  13. 32 CFR 310.52 - Computer matching publication and review requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Computer matching publication and review... OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Computer Matching Program Procedures § 310.52 Computer matching publication and review requirements. (a) DoD Components shall identify...

  14. 32 CFR 310.52 - Computer matching publication and review requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Computer matching publication and review... OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Computer Matching Program Procedures § 310.52 Computer matching publication and review requirements. (a) DoD Components shall identify...

  15. 32 CFR 310.52 - Computer matching publication and review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Computer matching publication and review... OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Computer Matching Program Procedures § 310.52 Computer matching publication and review requirements. (a) DoD Components shall identify...

  16. 32 CFR 310.52 - Computer matching publication and review requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Computer matching publication and review... OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Computer Matching Program Procedures § 310.52 Computer matching publication and review requirements. (a) DoD Components shall identify...

  17. 32 CFR 310.52 - Computer matching publication and review requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Computer matching publication and review... OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Computer Matching Program Procedures § 310.52 Computer matching publication and review requirements. (a) DoD Components shall identify...

  18. Characterization of and sensor-model verification and control of the properties of PMR-13 during processing

    NASA Technical Reports Server (NTRS)

    Kranbuehl, D.; Prettyman, T.; Robillard, K.; Smith, J.; Nicoletti, A.; Hart, S.; Loos, A.; Koury, Jim

    1991-01-01

    This study presents an in situ sensor and a process-simulation model developed for monitoring and controlling the cure process of PMR-15. The time-temperature dependence of the buildup in the molecular network structure, extent of reaction, viscosity, flow, and consolidation during the cure of PMR-15 are discussed. The relationship of the time-temperature cycle used during imidization to the length of the endcapped chains formed is examined. The relationship of the time-temperature cure-processing cycle to the reaction kinetics, viscosity, flow, and consolidation during crosslinking is analyzed using frequency-dependent electromagnetic sensors and the Loos processing model. Application of the FDEMS sensing technique and the process-simulation model for quality assurance processing and automated on-line control of cure is discussed.

  19. Peculiarities of the signals of the protons of the alkyl group at the boron atom in the PMR spectra

    SciTech Connect

    Kuznetsov, V.V.; Gren, A.I.; Zakharov, K.S.

    1985-05-01

    The authors note the peculiarities of the resonance signals of the alkyl group bonded to the boron atom. They present two charts of data gathered by the use of PMR spectroscopy. Analyzing these data, they conclude that observed peculiarities are probably due to chemical shifts of the protons of the methyl groups and of the methine proton, but they aver that a more profound analysis of the anomaly is impossible without a precise calculation of the spectra under discussion.

  20. 40 CFR 148.22 - Requirements for petition submission, review and approval or denial.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Requirements for petition submission, review and approval or denial. 148.22 Section 148.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) HAZARDOUS WASTE INJECTION RESTRICTIONS Petition Standards and Procedures § 148.22 Requirements...

  1. 40 CFR 148.22 - Requirements for petition submission, review and approval or denial.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Requirements for petition submission, review and approval or denial. 148.22 Section 148.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) HAZARDOUS WASTE INJECTION RESTRICTIONS Petition Standards and Procedures § 148.22 Requirements...

  2. 40 CFR 148.22 - Requirements for petition submission, review and approval or denial.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 24 2013-07-01 2013-07-01 false Requirements for petition submission, review and approval or denial. 148.22 Section 148.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) HAZARDOUS WASTE INJECTION RESTRICTIONS Petition Standards and Procedures § 148.22 Requirements...

  3. 75 FR 66724 - Notice of Public Information Collection Requirements Submitted to OMB for Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... DEVELOPMENT Notice of Public Information Collection Requirements Submitted to OMB for Review SUMMARY: U.S. Agency for International Development (USAID) has submitted the following information collections to OMB.... Purpose: The United States Agency for International Development (USAID) needs to require applicants...

  4. 14 CFR 420.27 - Launch site location review-information requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Launch site location review-information requirements. 420.27 Section 420.27 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LICENSE TO OPERATE A LAUNCH SITE Criteria and Information Requirements for Obtaining...

  5. Thermomechanical Properties of Interface Modified M40J Carbon/PMR-II-50 Composites

    NASA Technical Reports Server (NTRS)

    Allred, Ronald E.; Shin, E. Eugene; McCorkle, Linda; Inghram, Linda; Papadopoulos, Demetrios; Wheeler, Don; Sutter, James K.

    2003-01-01

    To increase performance and durability of high-temperature composites for potential rocket engine components, it is necessary to optimize wetting and interfacial bonding between high modulus carbon fibers and high-temperature polyimide resins. It has been previously demonstrated that the electro-oxidative shear treatments used by fiber manufacturers are not effective on higher modulus fibers that have fewer edge and defect sites in the surface crystallites. In addition, sizings commercially supplied on most carbon fibers are not compatible with polyimides. In this study, the surface chemistry and energy of high modulus carbon fibers (M40J and M60J, Torray) and typical fluorinated polyimide resins, such as PMR-11-50 were characterized. A continuous desizing system that uses an environmentally friendly chemical- mechanical process was developed for tow level fiber. Composites were fabricated with fibers containing the manufacturer's sizing, desized, and further treated with a reactive finish. Results of room temperature tests show that desizing reduces interface sensitive properties compared to the manufacturer's sizing and that subsequent surface re-treatment with reactive finish increases interface sensitive properties. Properties of thermally aged composites and composites with varying finish concentrations will also be discussed.

  6. Specimen geometry effects on graphite/PMR-15 composites during thermo-oxidative aging

    NASA Technical Reports Server (NTRS)

    Bowles, K. J.; Meyers, A.

    1986-01-01

    Studies were conducted to establish the effects of specimen geometry on the thermo-oxidative stability and the mechanical properties retention of unidirectional Celion 12000 graphite fiber reinforced PMR-15 polyimide composites. Weight loss, flexural strength and interlaminar shear strength are measured at isothermal aging times as long as 1639 hr at a temperature of 316 C for three different specimen geometries. It is found that the three different types of specimen surfaces exhibit different values of weight loss/unit area. The mechanical properties retention is also found to be dependent on geometry for these composites. The interlaminar shear strength decreases significantly over the complete range of aging times. The flexural strength retention starts showing geometric dependency after about 1000 hr of aging at 316C. Weight loss fluxes, associated with the three different types of exposed surfaces, are calculated and used to develop an empirical mathematical model for predicting the weight loss behavior of unidirectional composites of arbitrary geometries. Data are presented comparing experimentally determined weight loss with weight loss values predicted using the empirical model.

  7. Experimental investigation and CFD analysis on cross flow in the core of PMR200

    DOE PAGESBeta

    Lee, Jeong -Hun; Yoon, Su -Jong; Cho, Hyoung -Kyu; Jae, Moosung; Park, Goon -Cherl

    2015-04-16

    The Prismatic Modular Reactor (PMR) is one of the major Very High Temperature Reactor (VHTR) concepts, which consists of hexagonal prismatic fuel blocks and reflector blocks made of nuclear gradegraphite. However, the shape of the graphite blocks could be easily changed by neutron damage duringthe reactor operation and the shape change can create gaps between the blocks inducing the bypass flow.In the VHTR core, two types of gaps, a vertical gap and a horizontal gap which are called bypass gap and cross gap, respectively, can be formed. The cross gap complicates the flow field in the reactor core by connectingmore » the coolant channel to the bypass gap and it could lead to a loss of effective coolant flow in the fuel blocks. Thus, a cross flow experimental facility was constructed to investigate the cross flow phenomena in the core of the VHTR and a series of experiments were carried out under varying flow rates and gap sizes. The results of the experiments were compared with CFD (Computational Fluid Dynamics) analysis results in order to verify its prediction capability for the cross flow phenomena. Fairly good agreement was seen between experimental results and CFD predictions and the local characteristics of the cross flow was discussed in detail. Based on the calculation results, pressure loss coefficient across the cross gap was evaluated, which is necessary for the thermo-fluid analysis of the VHTR core using a lumped parameter code.« less

  8. Experimental investigation and CFD analysis on cross flow in the core of PMR200

    SciTech Connect

    Lee, Jeong -Hun; Yoon, Su -Jong; Cho, Hyoung -Kyu; Jae, Moosung; Park, Goon -Cherl

    2015-04-16

    The Prismatic Modular Reactor (PMR) is one of the major Very High Temperature Reactor (VHTR) concepts, which consists of hexagonal prismatic fuel blocks and reflector blocks made of nuclear gradegraphite. However, the shape of the graphite blocks could be easily changed by neutron damage duringthe reactor operation and the shape change can create gaps between the blocks inducing the bypass flow.In the VHTR core, two types of gaps, a vertical gap and a horizontal gap which are called bypass gap and cross gap, respectively, can be formed. The cross gap complicates the flow field in the reactor core by connecting the coolant channel to the bypass gap and it could lead to a loss of effective coolant flow in the fuel blocks. Thus, a cross flow experimental facility was constructed to investigate the cross flow phenomena in the core of the VHTR and a series of experiments were carried out under varying flow rates and gap sizes. The results of the experiments were compared with CFD (Computational Fluid Dynamics) analysis results in order to verify its prediction capability for the cross flow phenomena. Fairly good agreement was seen between experimental results and CFD predictions and the local characteristics of the cross flow was discussed in detail. Based on the calculation results, pressure loss coefficient across the cross gap was evaluated, which is necessary for the thermo-fluid analysis of the VHTR core using a lumped parameter code.

  9. Long-Term Isothermal Aging Effects on Carbon Fabric-Reinforced PMR-15 Composites: Compression Strength

    NASA Technical Reports Server (NTRS)

    Bowles, Kenneth J.; Roberts, Gary D.; Kamvouris, John E.

    1996-01-01

    A study was conducted to determine the effects of long-term isothermal thermo-oxidative aging on the compressive properties of T-650-35 fabric reinforced PMR-15 composites. The temperatures that were studied were 204, 260, 288, 316, and 343 C. Specimens of different geometries were evaluated. Cut edge-to-surface ratios of 0.03 to 0.89 were fabricated and aged. Aging times extended to a period in excess of 15,000 hours for the lower temperature runs. The unaged and aged specimens were tested in compression in accordance with ASTM D-695. Both thin and thick (plasma) specimens were tested. Three specimens were tested at each time/temperature/geometry condition. The failure modes appeared to be initiated by fiber kinking with longitudinal, interlaminar splitting. In general, it appears that the thermo-oxidative degradation of the compression strength of the composite material may occur by both thermal (time-dependent) and oxidative (weight-loss) mechanisms. Both mechanisms appear to be specimen-thickness dependent.

  10. A Limited Comparison of the Thermal Durability of Polyimide Candidate Matrix Polymers with PMR-15

    NASA Technical Reports Server (NTRS)

    Bowles, Kenneth J.; Papadopoulos, Demetrios S.; Scheiman, Daniel A.; Inghram, Linda L.; McCorkle, Linda S.; Klans, Ojars V.

    2003-01-01

    Studies were conducted with six different candidate high-temperature neat matrix resin specimens of varied geometric shapes to investigate the mechanisms involved in the thermal degradation of polyimides like PMR-15. The metrics for assessing the quality of these candidates were chosen to be glass transition temperature (T(sub g)), thermo-oxidative stability, dynamic mechanical properties, microstructural changes, and dimensional stability. The processing and mechanical properties were not investigated in the study reported herein. The dimensional changes and surface layer growth were measured and recorded. The data were in agreement with earlier published data. An initial weight increase reaction was observed to be dominating at the lower temperatures. However, at the more elevated temperatures, the weight loss reactions were prevalent and probably masked the weight gain reaction. These data confirmed the findings of the existence of an initial weight gain reaction previously reported. Surface- and core-dependent weight losses were shown to control the polymer degradation at the higher temperatures.

  11. Thermomechanical Fatigue Durability of T650-35/PMR-15 Sheet-Molding Compound Evaluated

    NASA Technical Reports Server (NTRS)

    Castelli, Michael G.

    1999-01-01

    High-performance polymer matrix composites (PMC's) continue to be the focus of a number of research efforts aimed at developing cost-effective, lightweight material alternatives for advanced aerospace and aeropropulsion applications. These materials not only offer significant advantages in specific stiffness and strength over their current metal counterparts, but they can be designed and manufactured to eliminate joints and fasteners by combining individual components into integral subassemblies, thus making them extremely attractive for commercial applications. With much emphasis on the low-cost manufacturing aspects of advanced composite structures, there is heightened interest in high-performance sheet-molding compounds (SMC's). Researchers at the NASA Lewis Research Center, in cooperation with the Allison Advanced Development Company, completed an investigation examining the use of T650-35/PMR-15 SMC for a midstage inner-vane endwall application within a gas turbine engine compressor. This component resides in the engine flow path and is subjected not only to high airflow rates, but also to elevated temperatures and pressures. This application is unique in that it represents a very aggressive use of high-performance SMC's, raising obvious concerns related to durability and property retention in the presence of microstructural damage. Therefore, it was necessary to evaluate the fatigue behavior and damage tolerance of this material subjected to a representative thermomechanical fatigue (TMF) mission-cycle loading spectrum.

  12. Assessment of documentation requirements under DOE 5481. 1, Safety Analysis and Review System (SARS)

    SciTech Connect

    Browne, E.T.

    1981-03-01

    This report assesses the requirements of DOE Order 5481.1, Safety Analysis and Review System for DOE Operations (SARS) in regard to maintaining SARS documentation. Under SARS, all pertinent details of the entire safety analysis and review process for each DOE operation are to be traceable from the initial identification of a hazard. This report is intended to provide assistance in identifying the points in the SARS cycle at which documentation is required, what type of documentation is most appropriate, and where it ultimately should be maintained.

  13. SAR compliance assessment of PMR 446 and FRS walkie-talkies.

    PubMed

    Vermeeren, Günter; Joseph, Wout; Martens, Luc

    2015-10-01

    The vast amount of studies on radiofrequency dosimetry deal with exposure due to mobile devices and base station antennas for cellular communication systems. This study investigates compliance of walkie-talkies to exposure guidelines established by the International Commission on Non-Ionizing Radiation Protection and the Federal Communications Committee. The generic walkie-talkie consisted of a helical antenna and a ground plane and was derived by reverse engineering of a commercial walkie-talkie. Measured and simulated values of antenna characteristics and electromagnetic near fields of the generic walkie-talkie were within 2% and 8%, respectively. We also validated normalized electromagnetic near fields of the generic walkie-talkie against a commercial device and observed a very good agreement (deviation <6%). We showed that peak localized specific absorption rate (SAR) induced in the oval flat phantom by the generic walkie-talkie is in agreement with four commercial devices if input power of the generic walkie-talkie is rescaled based on magnetic near field. Finally, we found that SAR of commercial devices is within current SAR limits for general public exposure for a worst-case duty cycle of 100%, that is, about 3 times and 6 times lower than the limit on the 1 g SAR (1.6 W/kg) and 10 g SAR (2 W/kg), respectively. But, an effective radiated power as specified by the Private Mobile Radio at 446 MHz (PMR 446) radio standard can cause localized SAR exceeding SAR limits for 1 g of tissue. PMID:26344699

  14. 18 CFR 806.5 - Projects that may require review and approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Projects that may require review and approval. 806.5 Section 806.5 Conservation of Power and Water Resources SUSQUEHANNA... under § 806.4, and provided that the project sponsor is notified in writing by the Executive...

  15. 18 CFR 806.5 - Projects that may require review and approval.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Projects that may require review and approval. 806.5 Section 806.5 Conservation of Power and Water Resources SUSQUEHANNA... under § 806.4, and provided that the project sponsor is notified in writing by the Executive...

  16. 75 FR 81204 - Notice of Public Information Collection Requirements Submitted to OMB for Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ...; ] AGENCY FOR INTERNATIONAL DEVELOPMENT Notice of Public Information Collection Requirements Submitted to OMB for Review SUMMARY: U.S. Agency for International Development (USAID) has submitted the following... Initiatives (CFBCI) supports the commitment from the White F-louse and USAID to expand our...

  17. 42 CFR 475.104 - Requirements for demonstrating ability to perform review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Requirements for demonstrating ability to perform review. 475.104 Section 475.104 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS QUALITY IMPROVEMENT...

  18. 42 CFR 475.104 - Requirements for demonstrating ability to perform review.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Requirements for demonstrating ability to perform review. 475.104 Section 475.104 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS QUALITY IMPROVEMENT...

  19. 75 FR 75451 - Notice of Public Information Collection Requirements Submitted to OMB for Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ...; ] AGENCY FOR INTERNATIONAL DEVELOPMENT Notice of Public Information Collection Requirements Submitted to OMB for Review SUMMARY: U.S. Agency for International Development (USAID) has submitted the following... Submission: Renewal of Information Collections. Purpose: The U.S. Agency for International Development...

  20. 48 CFR 801.602-81 - Documents required for business clearance reviews.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Documents required for business clearance reviews. 801.602-81 Section 801.602-81 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL DEPARTMENT OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM...

  1. 48 CFR 801.602-81 - Documents required for business clearance reviews.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Documents required for business clearance reviews. 801.602-81 Section 801.602-81 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL DEPARTMENT OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM...

  2. 48 CFR 801.602-81 - Documents required for business clearance reviews.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Documents required for business clearance reviews. 801.602-81 Section 801.602-81 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL DEPARTMENT OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM...

  3. 42 CFR 488.64 - Remote facility variances for utilization review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Remote facility variances for utilization review requirements. 488.64 Section 488.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND...

  4. 14 CFR 435.43 - Payload reentry review requirements and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Payload reentry review requirements and procedures. 435.43 Section 435.43 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Payload...

  5. 40 CFR 51.1011 - Requirements for mid-course review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PM2.5 National Ambient Air Quality Standards § 51.1011 Requirements for mid-course review. (a) Any State that submits to EPA an approvable attainment plan for a PM2.5 nonattainment area justifying an... direct PM2.5 and PM2.5 attainment plan precursors contributing to PM2.5 concentrations in the area;...

  6. 40 CFR 51.1011 - Requirements for mid-course review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PM2.5 National Ambient Air Quality Standards § 51.1011 Requirements for mid-course review. (a) Any State that submits to EPA an approvable attainment plan for a PM2.5 nonattainment area justifying an... direct PM2.5 and PM2.5 attainment plan precursors contributing to PM2.5 concentrations in the area;...

  7. 40 CFR 51.1011 - Requirements for mid-course review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PM2.5 National Ambient Air Quality Standards § 51.1011 Requirements for mid-course review. (a) Any State that submits to EPA an approvable attainment plan for a PM2.5 nonattainment area justifying an... direct PM2.5 and PM2.5 attainment plan precursors contributing to PM2.5 concentrations in the area;...

  8. 40 CFR 51.1011 - Requirements for mid-course review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PM2.5 National Ambient Air Quality Standards § 51.1011 Requirements for mid-course review. (a) Any State that submits to EPA an approvable attainment plan for a PM2.5 nonattainment area justifying an... direct PM2.5 and PM2.5 attainment plan precursors contributing to PM2.5 concentrations in the area;...

  9. 78 FR 62638 - Agency Recordkeeping/Reporting Requirements Under Emergency Review by the Office of Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Agency Recordkeeping/Reporting Requirements Under Emergency Review by the Office of Management and Budget (OMB) Title: Low Income Home Energy Assistance Program (LIHEAP) Grantee Needs...

  10. Comparison of Graphite Fabric Reinforced PMR-15 and Avimid N Composites After Long Term Isothermal Aging at Various Temperatures

    NASA Technical Reports Server (NTRS)

    Bowles, Kenneth J.; McCorkle, Linda; Ingrahm, Linda

    1998-01-01

    Extensive effort is currently being expended to demonstrate the feasibility of using high-performance, polymer-matrix composites as engine structural materials over the expected operating lifetime of the aircraft, which can extend from 18,000 to 30,000 hr. The goal is to develop light-weight, high-strength, and high-modulus materials for use in higher temperature sections of advanced 21 st century aircraft propulsion systems. To accomplish this goal, it is necessary to pursue the development of thermal and mechanical durability models for graphite-fiber-reinforced, polymer-matrix composites. Numerous investigations have been reported regarding the thermo-oxidative stability (TOS) of the polyimide PMR-15 (1-5). A significant amount of this work has been directed at edge and geometry effects, reinforcement fiber influences, and empirical modeling of high-temperature weight loss behavior. It is yet to be determined if the information obtained from the PMR-15 composite tests is applicable to other polyimide-matrix composites. The condensation-curing polymer Avimid N is another advanced composite material often considered for structural applications at high temperatures. Avimid N has better thermo-oxidative stability than PMR-15 (6), but the latter is more easily processed. The most comprehensive study of the thermo-oxidative stability of Avimid N neat resin and composites at 371 (infinity)C is found in Salin and Seferis (7). The purposes of the work described herein were to compare the thermal aging behavior of these two matrix polymers and to determine the reasons for and the consequences of the difference in thermal durability. These results might be of some use in improving future polymer development through the incorporation of the desirable characteristics of both polyimides.

  11. Scientific and Regulatory Policy Committee Review: Review of the Organisation for Economic Co-operation and Development (OECD) Guidance on the GLP Requirements for Peer Review of Histopathology.

    PubMed

    Fikes, James D; Patrick, Daniel J; Francke, Sabine; Frazier, Kendall S; Reindel, James F; Romeike, Annette; Spaet, Robert H; Tomlinson, Lindsay; Schafer, Kenneth A

    2015-10-01

    In 2014, the Organisation for Economic Co-operation and Development (OECD) issued guidance no. 16, Guidance on the GLP Requirements for Peer Review of Histopathology. The stated purpose of the guidance document is "to provide guidance to pathologists, test facility management, study directors and quality assurance personnel on how the peer review of histopathology should be planned, managed, documented, and reported in order to meet Good Laboratory Practice (GLP) expectations and requirements." On behalf of and in collaboration with the global societies of toxicologic pathology, the Society of Toxicologic Pathology initiated a review of OECD guidance no. 16. The objectives of this review are to provide a unified interpretation of the guidance, to recommend compliant processes for organizations to implement, and to avoid inconsistent process adaptations across the industry. This review of the guidance document is the product of a global collaboration with other societies of toxicologic pathology and provides a section-by-section international consensus view and interpretation of the OECD guidance on peer review. PMID:26208968

  12. PMR Characterization of the Water Structure in Tibetan Milk Mushroom Zooglea: Influence of Medium Hydration and Hydrophobicity

    NASA Astrophysics Data System (ADS)

    Krupskaya, T. V.; Prylutskyy, Yu. I.; Evstigneev, M. P.; Tsapko, M. D.; Turov, V. V.

    2015-07-01

    The state of water in Tibetan milk mushroom zooglea with different degrees of hydration (h) was investigated using low-temperature PMR spectroscopy in air and in contact with the hydrophobic media polydimethylsiloxane PDMS-1000 and CHCl3 with added trifl uoroacetic acid (TFA). The maximum hydration of the zooglea amounted to h = 32 g/g (of dry matter). Water existed as polyassociates (clusters or domains) of strongly and weakly associated water. Bound water decomposed into clusters in the presence of TFA. The NMR spectra showed six types of bound water at h = 0.3 g/g.

  13. Cationic antimicrobial peptides serve as activation signals for the Salmonella Typhimurium PhoPQ and PmrAB regulons in vitro and in vivo

    PubMed Central

    Richards, Susan M.; Strandberg, Kristi L.; Conroy, Megan; Gunn, John S.

    2012-01-01

    Salmonella enterica serovar Typhimurium uses two-component regulatory systems (TCRSs) to respond to environmental stimuli. Upon infection, the TCRSs PhoP-PhoQ (PhoPQ) and PmrA-PmrB (PmrAB) are activated by environmental signals detected in the lumen of the intestine and within host cells. TCRS-mediated gene expression leads to upregulation of genes involved in lipopolysaccharide (LPS) modification and cationic antimicrobial peptide (CAMP) resistance. This research expands on previous studies which have shown that CAMPs can activate Salmonella TCRSs in vitro. The focus of this work was to determine if CAMPs can act as environmental signals for PhoPQ- and PmrAB-mediated gene expression in vitro, during infection of macrophages and in a mouse model of infection. Monitoring of PhoPQ and PmrAB activation using recombinase-based in vivo expression technology (RIVET), alkaline phosphtase and β-galactosidase reporter fusion constructs demonstrated that S. Typhimurium PhoQ can sense CAMPs in vitro. In mouse macrophages, the cathelecidin CRAMP does not activate the PhoPQ regulon. Acidification of the Salmonella-containing vacuole activates PhoP- and PmrA-regulated loci but blocking acidification still does not reveal a role for CRAMP in TCRS activation in mouse macrophages. However, assays performed in susceptible wild type (WT), CRAMP knockout (KO), and matrilysin (a metalloproteinase necessary for activating murine α-defensins) KO mice suggest CRAMP, but not α-defensins, serve as a putative direct TCRS activation signal in the mouse intestine. These studies provide a better understanding of the in vivo environments that result in activation of these virulence-associated TCRSs. PMID:22919691

  14. Quality Control and Peer Review of Data Sets: Mapping Data Archiving Processes to Data Publication Requirements

    NASA Astrophysics Data System (ADS)

    Mayernik, M. S.; Daniels, M.; Eaker, C.; Strand, G.; Williams, S. F.; Worley, S. J.

    2012-12-01

    ? What data set review can be done pre-publication, and what must be done post-publication? What components of the data sets review processes can be automated, and what components will always require human expertise and evaluation?

  15. Factors determining insulin requirements in women with type 1 diabetes mellitus during pregnancy: a review

    PubMed Central

    McIntyre, Harold David; Callaway, Leonie

    2014-01-01

    Most women with type 1 diabetes mellitus (T1DM) have increased insulin requirements during pregnancy. However, a minority of women have a fall in insulin requirements. When this occurs in late gestation, it often provokes concern regarding possible compromise of the feto-placental unit. In some centres, this is considered as an indication for delivery, including premature delivery. There are, however, many other factors that affect insulin requirements in pregnancy in women with type 1 diabetes mellitus and the decline in insulin requirements may represent a variant of normal pregnancy. If there is no underlying pathological process, expedited delivery in these women is not warranted and confers increased risks to the newborn. We will explore the factors affecting insulin requirements in gestation in this review. We will also discuss some novel concepts regarding beta-cell function in pregnancy.

  16. NRC review of Electric Power Research Institute's Advanced Light Reactor Utility Requirements Document - Program summary, Project No. 669

    SciTech Connect

    Not Available

    1992-08-01

    The staff of the US Nuclear Regulatory Commission has prepared Volume 1 of a safety evaluation report (SER), NRC Review of Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document -- Program Summary,'' to document the results of its review of the Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document.'' This SER provides a discussion of the overall purpose and scope of the Requirements Document, the background of the staff's review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review.

  17. Muscle phosphoglycerate mutase (PGAM) deficiency in the first Caucasian patient: biochemistry, muscle culture and 31P-MR spectroscopy.

    PubMed

    Vita, G; Toscano, A; Bresolin, N; Meola, G; Fortunato, F; Baradello, A; Barbiroli, B; Frassineti, C; Zaniol, P; Messina, C

    1994-03-01

    Muscle phosphoglycerate mutase (PGAM) deficiency has been so far identified in only six patients, five of these being African Americans. We report the results of clinical, morphological, biochemical, muscle culture and 31P-MR spectroscopy studies in the first Caucasian patient with muscle PGAM deficiency. A 23-year-old man had a 10-year history of cramps after physical exertion with one episode of pigmenturia. Neurological examination and EMG study were normal. ECG and echocardiography revealed hypertrophy of the interventricular septum and slight dilation of the left chambers of the heart. Muscle biopsy revealed increased glycogen content and some accumulation of mitochondria. Muscle PGAM activity was markedly decreased (6.5% and 9.7% of control value in two different biopsies). Citrate synthase and other mitochondrial respiratory chain enzyme activities were much higher than normal. In contrast to the marked decrease of PGAM activity observed in muscle biopsy, total enzyme activity in the patient's aneural muscle culture was normal, being represented exclusively by BB isoenzyme. The deficiency of PGAM-MM isoenzyme was reproduced in the patient's innervated muscle culture. Muscle 31P-MR spectroscopy showed accumulation of phosphomonoesters only on fast "glycolytic" exercise. On "aerobic" exercise, Vmax, calculated from the work-energy cost transfer function, showed an increase consistent with the morphological and biochemical evidence of mitochondrial proliferation. This might represent a sort of compensatory aerobic effort in an attempt to restore muscle power. PMID:8006681

  18. Comparison of SMR, PMR, and PCMR in a cohort of union members potentially exposed to diesel exhaust emissions.

    PubMed Central

    Wong, O; Morgan, R W; Kheifets, L; Larson, S R

    1985-01-01

    A comparison of cause specific standarised mortality ratios (SMRs) and proportionate mortality ratios (PMRs) or proportionate cancer mortality ratios (PCMRs) was made based on the mortality experience of a cohort of 34 156 members of a heavy equipment operators union. Two types of PMRs or PCMRs were used in the comparison: those based on all deaths and those based on deaths known to the union only. The comparison indicated that, for the entire cohort, both types of PMRs were poor indicators for cancer risk and produced a large number of false positives. On the other hand, PCMRs appeared to be better than PMRs for assessing the direction of site specific cancer risk, but they tended to overstate the magnitude of risk. Analysis by duration of union membership or latency indicated that PMRs or PCMRs based on deaths known to the union tended to overestimate the risk of lung cancer by disproportionately larger amounts in groups with shorter time than in groups with longer time. This differential bias had the net effect of reducing the gradient of any trend or eliminating the trend entirely. In conclusion, PMR or PCMR, based on reasonably sufficient death ascertainment, has a certain usefulness in generating hypotheses, but they are not useful or reliable in measuring the magnitude of risk or in detecting trends in dose response analysis. No conclusion should be drawn from either PMR or PCMR. PMID:2410011

  19. Thermomechanical Fatigue Durability of T650-35/PMR-15 Sheet Molding Compound

    NASA Technical Reports Server (NTRS)

    Castelli, Michael G.; Sutter, James K.; Benson, Dianne

    1998-01-01

    Although polyimide based composites have been used for many years in a wide variety of elevated temperature applications, very little work has been done to examine the durability and damage behavior under more prototypical thermomechanical fatigue (TMF) loadings. Synergistic effects resulting from simultaneous temperature and load cycling can potentially lead to enhanced, if not unique, damage modes and contribute to a number of nonlinear deformation responses. The goal of this research was to examine the effects of a TMF loading spectrum, representative of a gas turbine engine compressor application, on a polyimide sheet molding compound (SMC). High performance SMCs present alternatives to prepreg forms with great potential for low cost component production through less labor intensive, more easily automated manufacturing. To examine the issues involved with TMF, a detailed experimental investigation was conducted to characterize the durability of a T650-35/PMR-15 SMC subjected to TMF mission cycle loadings. Fatigue damage progression was tracked through macroscopic deformation and elastic stiffness. Additional properties, such as the glass transition temperature (T(sub g) and dynamic mechanical properties were examined. The fiber distribution orientation was also characterized through a detailed quantitative image analysis. Damage tolerance was quantified on the basis of residual static tensile properties after a prescribed number of TMF missions. Detailed microstructural examinations were conducted using optical and scanning electron microscopy to characterize the local damage. The imposed baseline TMF missions had only a modest impact on inducing fatigue damage with no statistically significant degradation occurring in the measured macroscopic properties. Microstructural damage was, however, observed subsequent to 100 h of TMF cycling which consisted primarily of fiber debonding and transverse cracking local to predominantly transverse fiber bundles. The TMF

  20. Round Table Part 1: Review of future manned missions and Identification key ECLSS requirements.

    NASA Astrophysics Data System (ADS)

    Lasseur, Christophe; Wheeler, Raymond; Tikhomirova, Natalia; Joshi, Jitendra; Dussap, Gilles; Godia, Francesc

    2016-07-01

    All forecast an end of ISS in 2024. What so ever will be the exact date date the main part of the space agencies are currently elaborating plans for future manned missions. So far mainly 3 destination are considered :" Moon, Mars and Lagrange point L2. Depending of the missions duration, crew size, safety .. the ECLSS will have major difference . In this first part of the round table it is proposed to review the main missions scenario and elaborate top level requirements.

  1. 34 CFR 461.46 - What requirements for program reviews and evaluations must be met by a State?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Program (See 34 CFR part 463). (Approved by the Office of Management and Budget under control number 1830... 34 Education 3 2010-07-01 2010-07-01 false What requirements for program reviews and evaluations... requirements for program reviews and evaluations must be met by a State? (a) An SEA shall provide for...

  2. 34 CFR 461.46 - What requirements for program reviews and evaluations must be met by a State?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Program (See 34 CFR part 463). (Approved by the Office of Management and Budget under control number 1830... 34 Education 3 2011-07-01 2011-07-01 false What requirements for program reviews and evaluations... requirements for program reviews and evaluations must be met by a State? (a) An SEA shall provide for...

  3. 40 CFR 51.914 - What new source review requirements apply for 8-hour ozone nonattainment areas?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... apply for 8-hour ozone nonattainment areas? 51.914 Section 51.914 Protection of Environment... Standard § 51.914 What new source review requirements apply for 8-hour ozone nonattainment areas? The requirements for new source review for the 8-hour ozone standard are located in § 51.165 of this part....

  4. 48 CFR 2937.103-70 - Department of Labor checklist to aid analysis and review of requirements for service contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... checklist to aid analysis and review of requirements for service contracts. 2937.103-70 Section 2937.103-70 Federal Acquisition Regulations System DEPARTMENT OF LABOR GENERAL CONTRACTING REQUIREMENTS SERVICE CONTRACTING Service Contracts-General 2937.103-70 Department of Labor checklist to aid analysis and review...

  5. 48 CFR 2937.103-70 - Department of Labor checklist to aid analysis and review of requirements for service contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... checklist to aid analysis and review of requirements for service contracts. 2937.103-70 Section 2937.103-70 Federal Acquisition Regulations System DEPARTMENT OF LABOR GENERAL CONTRACTING REQUIREMENTS SERVICE CONTRACTING Service Contracts-General 2937.103-70 Department of Labor checklist to aid analysis and review...

  6. 48 CFR 2937.103-70 - Department of Labor checklist to aid analysis and review of requirements for service contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... checklist to aid analysis and review of requirements for service contracts. 2937.103-70 Section 2937.103-70 Federal Acquisition Regulations System DEPARTMENT OF LABOR GENERAL CONTRACTING REQUIREMENTS SERVICE CONTRACTING Service Contracts-General 2937.103-70 Department of Labor checklist to aid analysis and review...

  7. 48 CFR 2937.103-70 - Department of Labor checklist to aid analysis and review of requirements for service contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... checklist to aid analysis and review of requirements for service contracts. 2937.103-70 Section 2937.103-70 Federal Acquisition Regulations System DEPARTMENT OF LABOR GENERAL CONTRACTING REQUIREMENTS SERVICE CONTRACTING Service Contracts-General 2937.103-70 Department of Labor checklist to aid analysis and review...

  8. 48 CFR 2937.103-70 - Department of Labor checklist to aid analysis and review of requirements for service contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... checklist to aid analysis and review of requirements for service contracts. 2937.103-70 Section 2937.103-70 Federal Acquisition Regulations System DEPARTMENT OF LABOR GENERAL CONTRACTING REQUIREMENTS SERVICE CONTRACTING Service Contracts-General 2937.103-70 Department of Labor checklist to aid analysis and review...

  9. Left Internal Mammary Artery Injury Requiring Resuscitative Thoracotomy: A Case Presentation and Review of the Literature

    PubMed Central

    Al Hassani, Ammar; Abdul Rahman, Yassir; Kanbar, Ahad; El-Menyar, Ayman; Al-Aieb, Abubaker; Asim, Mohammad; Latifi, Rifat

    2012-01-01

    Background. Penetrating injuries to the chest and in particular to the heart that results in pericardial tamponade and cardiac arrest requires immediate resuscitative thoracotomy as the only lifesaving technique and should be performed without delay. Objective. To describe an external cardiac tamponade caused by massive tension hemothorax from penetrating injury of the left internal mammary artery (LIMA). Method. A case presentation treated at the Level I trauma center at Hamad General Hospital, in Doha, Qatar and review of the literature on LIMA injuries reported cases. Results. LIMA injury as a cause of hemothorax is not uncommon, but to our knowledge our case is the first massive tension hemothorax with witnessed cardiac arrest reported in the literature requiring emergency thoracotomy, performed in trauma room, with full recovery. Conclusion. Injury to the LIMA with massive tension hemothorax requires immediate resuscitative thoracotomy. PMID:23326745

  10. Understanding of Essential Elements Required in Informed Consent Form among Researchers and Institutional Review Board Members.

    PubMed

    Koonrungsesomboon, Nut; Laothavorn, Junjira; Karbwang, Juntra

    2015-06-01

    The process of informed consent remains a constant challenge in clinical research. The aim of the present study was to evaluate the understanding of researchers and members of Institutional Review Boards (IRBs) regarding the essential elements of an Informed Consent Form (ICF) as required by internationally recognized regulations. Using eight case studies to illustrate basic ethical elements, the study involved 107 participants, mainly from the Asia Pacific and African regions. The results showed that most of the participants had general knowledge regarding the essential elements required in an ICF. However, the issues of confidentiality of data and payment for study participation proved to be problematic for some participants, accounting for 35% and 28% of all incorrect answers respectively. This suggests that participants' understanding of the underlying concepts of the required ICF elements is limited. Ethical training of researchers and IRB members, particularly in the Asia Pacific and African regions, concerning valid informed consent is still needed. PMID:26161029

  11. Understanding of Essential Elements Required in Informed Consent Form among Researchers and Institutional Review Board Members

    PubMed Central

    Koonrungsesomboon, Nut; Laothavorn, Junjira; Karbwang, Juntra

    2015-01-01

    The process of informed consent remains a constant challenge in clinical research. The aim of the present study was to evaluate the understanding of researchers and members of Institutional Review Boards (IRBs) regarding the essential elements of an Informed Consent Form (ICF) as required by internationally recognized regulations. Using eight case studies to illustrate basic ethical elements, the study involved 107 participants, mainly from the Asia Pacific and African regions. The results showed that most of the participants had general knowledge regarding the essential elements required in an ICF. However, the issues of confidentiality of data and payment for study participation proved to be problematic for some participants, accounting for 35% and 28% of all incorrect answers respectively. This suggests that participants’ understanding of the underlying concepts of the required ICF elements is limited. Ethical training of researchers and IRB members, particularly in the Asia Pacific and African regions, concerning valid informed consent is still needed. PMID:26161029

  12. Putative PmrA and PmcA are important for normal growth, morphogenesis and cell wall integrity, but not for viability in Aspergillus nidulans.

    PubMed

    Jiang, Hechun; Liu, Feifei; Zhang, Shizhu; Lu, Ling

    2014-11-01

    P-type Ca(2+)-transporting ATPases are Ca(2+) pumps, extruding cytosolic Ca(2+) to the extracellular environment or the intracellular Ca(2+) store lumens. In budding yeast, Pmr1 (plasma membrane ATPase related), and Pmc1 (plasma membrane calcium-ATPase) cannot be deleted simultaneously for it to survive in standard medium. Here, we deleted two putative Ca(2+) pumps, designated AnPmrA and AnPmcA, from Aspergillus nidulans, and obtained the mutants ΔanpmrA and ΔanpmcA, respectively. Then, using ΔanpmrA as the starting strain, the promoter of its anpmcA was replaced with the alcA promoter to secure the mutant ΔanpmrAalcApmcA or its anpmcA was deleted completely to produce the mutant ΔanpmrAΔpmcA. Different from the case in Saccharomyces cerevisiae, double deletion of anpmrA and anpmcA was not lethal in A. nidulans. In addition, deletion of anpmrA and/or anpmcA had produced growth defects, although overexpression of AnPmc1 in ΔanpmrAalcApmcA could not restore the growth defects that resulted from the loss of AnPmrA. Moreover, we found AnPmrA was indispensable for maintenance of normal morphogenesis, especially in low-Ca(2+)/Mn(2+) environments. Thus, our findings suggest AnPmrA and AnPmcA might play important roles in growth, morphogenesis and cell wall integrity in A. nidulans in a different way from that in yeasts. PMID:25118249

  13. Review of current practices and requirements for the inspection of prestressed concrete pressure vessels

    SciTech Connect

    Reimann, K.J.

    1980-12-01

    Code requirements for pre- and in-service inspection of prestressed concrete pressure vessels as utilized in gas-cooled reactors are reviewed and compared with practices and experiences during construction, commissioning, and operation of such reactors. The pre-service inspection relies heavily on embedded instrumentation for measurements of stresses, temperatures, and displacements. The same instrumentation is later used for in-service surveillance, which additionally includes visual examination of exposed surfaces, monitoring of tendon conditions, and measurement of tendon loads. Improvement of present monitoring instrumentation and/or techniques, rather than development of new in-service inspection methods, is recommended.

  14. Thermal management in heavy vehicles : a review identifying issues and research requirements.

    SciTech Connect

    Wambsganss, M. W.

    1999-01-15

    Thermal management in heavy vehicles is cross-cutting because it directly or indirectly affects engine performance, fuel economy, safety and reliability, engine/component life, driver comfort, materials selection, emissions, maintenance, and aerodynamics. It follows that thermal management is critical to the design of large (class 6-8) trucks, especially in optimizing for energy efficiency and emissions reduction. Heat rejection requirements are expected to increase, and it is industry's goal to develop new, innovative, high-performance cooling systems that occupy less space and are lightweight and cost-competitive. The state of the art in heavy vehicle thermal management is reviewed, and issues and research areas are identified.

  15. Reviews.

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 1990

    1990-01-01

    Reviewed are two computer software packages: "Introduction to Spectroscopy, IR, NMR & CMR," and "ASYSTANT" (a mathematical and statistical analysis software tool). Discussed are the functions, strengths, weaknesses, hardware requirements, components, level, and cost for each package. (CW)

  16. Tumefactive multiple sclerosis requiring emergency craniotomy: case report and literature review.

    PubMed

    Munarriz, Pablo M; Castaño-Leon, Ana M; Martinez-Perez, Rafael; Hernandez-Lain, Aurelio; Ramos, Ana; Lagares, Alfonso

    2013-01-01

    Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, characterized by focal neurological dysfunction with a relapsing and remitting course. Tumor-like presentation of MS (or "tumefactive"/"pseudotumoral" presentation) has been described before with a certain frequency; it consists of a large single plaque (>2cm) with presence of edema and mass effect and it is hard to distinguish from a brain tumor. However, we present a very rare case of a 53-year-old woman with a right temporal mass that turned out to be a MS plaque, who deteriorated within hours (brain herniation with loss of consciousness and unilateral mydriasis) and required an emergency craniotomy. We also present a review of the literature. It appears that only 4 cases of emergency craniotomy/craniectomy required in a patient with a tumor-like MS plaque have been reported before. PMID:23582489

  17. 42 CFR 476.74 - General requirements for the assumption of review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS UTILIZATION AND QUALITY CONTROL REVIEW Review Responsibilities of Utilization and Quality Control Quality Improvement Organizations (QIOs... subcontract with a facility to conduct any review activities except for the review of the quality of care....

  18. 42 CFR 476.74 - General requirements for the assumption of review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS UTILIZATION AND QUALITY CONTROL REVIEW Review Responsibilities of Utilization and Quality Control Quality Improvement Organizations (QIOs... subcontract with a facility to conduct any review activities except for the review of the quality of care....

  19. 34 CFR 86.102 - What is required of an IHE that the Secretary selects for annual review?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false What is required of an IHE that the Secretary selects for annual review? 86.102 Section 86.102 Education Office of the Secretary, Department of Education DRUG AND ALCOHOL ABUSE PREVENTION Institutions of Higher Education § 86.102 What is required of an IHE that the Secretary selects for annual review?...

  20. [Review on requirements of drug allergy or pseudoallergic reactions in pre-clinical evaluation].

    PubMed

    Han, Jia-yin; Yi, Yan; Liang, Ai-hua; Zhang, Yu-shi; Li, Chun-ying; Zhao, Yong; Wang, Lian-mei; Lu, Yu-ting; Li, Gui-qin

    2015-07-01

    Drug allergy and pseudoallergic reactions are main adverse drug reactions. Allergy is mainly induced by the immunogenicity of drug, drug metabolic products or drug additive. Pseudoallergic reactions may result from the irritation or activation of inflammatory material release. Pre-clinical evaluation of drug allergy and pseudoallergic reactions is included in immunotoxicity evaluation. Now there is no in vivo or in vitro method that could predict all kinds of allergy or pseudoallergic reactions due to the different mechanisms. In the past few years, FDA, SFDA OECD, ICH and WHO have published several guidelines on per-clinical immunotoxicity evaluation, however, no agreement has been reached on allergy and pseudoallergic reactions evaluation. This article reviews the requirements of allergy and pseudoallergic reactions in pre-clinical evaluation. PMID:26666009

  1. Fractured rock modeling in the National Waste Terminal Storage Program: a review of requirements and status

    SciTech Connect

    St. John, C.; Krug, A.; Key, S.; Monsees, J.

    1983-05-01

    Generalized computer codes capable of forming the basis for numerical models of fractured rock masses are being used within the NWTS program. Little additional development of these codes is considered justifiable, except in the area of representation of discrete fractures. On the other hand, model preparation requires definition of medium-specific constitutive descriptions and site characteristics and is therefore legitimately conducted by each of the media-oriented projects within the National Waste Terminal Storage program. However, it is essential that a uniform approach to the role of numerical modeling be adopted, including agreement upon the contribution of modeling to the design and licensing process and the need for, and means of, model qualification for particular purposes. This report discusses the role of numerical modeling, reviews the capabilities of several computer codes that are being used to support design or performance assessment, and proposes a framework for future numerical modeling activities within the NWTS program.

  2. Trading Land: A Review of Approaches to Accounting for Upstream Land Requirements of Traded Products

    PubMed Central

    Haberl, Helmut; Kastner, Thomas; Wiedenhofer, Dominik; Eisenmenger, Nina; Erb, Karl‐Heinz

    2015-01-01

    Summary Land use is recognized as a pervasive driver of environmental impacts, including climate change and biodiversity loss. Global trade leads to “telecoupling” between the land use of production and the consumption of biomass‐based goods and services. Telecoupling is captured by accounts of the upstream land requirements associated with traded products, also commonly referred to as land footprints. These accounts face challenges in two main areas: (1) the allocation of land to products traded and consumed and (2) the metrics to account for differences in land quality and land‐use intensity. For two main families of accounting approaches (biophysical, factor‐based and environmentally extended input‐output analysis), this review discusses conceptual differences and compares results for land footprints. Biophysical approaches are able to capture a large number of products and different land uses, but suffer from a truncation problem. Economic approaches solve the truncation problem, but are hampered by the limited disaggregation of sectors and products. In light of the conceptual differences, the overall similarity of results generated by both types of approaches is remarkable. Diametrically opposed results for some of the world's largest producers and consumers of biomass‐based products, however, make interpretation difficult. This review aims to provide clarity on some of the underlying conceptual issues of accounting for land footprints. PMID:27547028

  3. Review of requirements and status of simulation and scaling of transonic, viscous flows

    NASA Astrophysics Data System (ADS)

    Potter, J. L.

    1984-09-01

    The elements of transonic, viscous-flow simulation are reviewed, documented, and briefly evaluated in the light of newer results from research in this field. Not only the case of wing flows at low angles of attack, but also the problems arising with wings and fuselages or missiles at higher angles are discussed. Criteria to be satisfied in scale-model testing and means for doing that are the principal topics covered. This includes the experimental techniques for simulating shock wave-boundary layer interaction, obtaining full-scale shock location and overall aerodynamic coefficients, and the precautions associated with boundary layer tripping in various types of testing. Vortical flows receive attention, and the requirement for assessing Reynolds number effects is emphasized. The review brings together information from diverse sources that wind tunnel test planners need in further improving experimental results and which is also critical in extrapolating those data to full-scale flight conditions. The subject of this report will continue to be of concern even though capabilities in computational fluid dynamics are rapidly growing, and the recently dedicated National Transonic Facility at the Langley Research Center will provide much increased test Reynolds numbers.

  4. 34 CFR 86.102 - What is required of an IHE that the Secretary selects for annual review?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false What is required of an IHE that the Secretary selects for annual review? 86.102 Section 86.102 Education Office of the Secretary, Department of Education DRUG AND ALCOHOL ABUSE PREVENTION Institutions of Higher Education § 86.102 What is required of an...

  5. 34 CFR 86.102 - What is required of an IHE that the Secretary selects for annual review?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What is required of an IHE that the Secretary selects for annual review? 86.102 Section 86.102 Education Office of the Secretary, Department of Education DRUG AND ALCOHOL ABUSE PREVENTION Institutions of Higher Education § 86.102 What is required of an...

  6. 34 CFR 86.102 - What is required of an IHE that the Secretary selects for annual review?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false What is required of an IHE that the Secretary selects for annual review? 86.102 Section 86.102 Education Office of the Secretary, Department of Education DRUG AND ALCOHOL ABUSE PREVENTION Institutions of Higher Education § 86.102 What is required of an...

  7. 34 CFR 86.102 - What is required of an IHE that the Secretary selects for annual review?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false What is required of an IHE that the Secretary selects for annual review? 86.102 Section 86.102 Education Office of the Secretary, Department of Education DRUG AND ALCOHOL ABUSE PREVENTION Institutions of Higher Education § 86.102 What is required of an...

  8. 21 CFR 610.48 - Hepatitis C virus (HCV) “lookback” requirements based on review of historical testing records.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Hepatitis C virus (HCV) âlookbackâ requirements... STANDARDS Testing Requirements for Communicable Disease Agents § 610.48 Hepatitis C virus (HCV) “lookback... the following actions: (1) You must: (i) Review all records of donor testing for hepatitis C...

  9. 21 CFR 610.48 - Hepatitis C virus (HCV) “lookback” requirements based on review of historical testing records.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Hepatitis C virus (HCV) âlookbackâ requirements... STANDARDS Testing Requirements for Communicable Disease Agents § 610.48 Hepatitis C virus (HCV) “lookback... the following actions: (1) You must: (i) Review all records of donor testing for hepatitis C...

  10. 21 CFR 610.48 - Hepatitis C virus (HCV) “lookback” requirements based on review of historical testing records.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Hepatitis C virus (HCV) âlookbackâ requirements... STANDARDS Testing Requirements for Communicable Disease Agents § 610.48 Hepatitis C virus (HCV) “lookback... the following actions: (1) You must: (i) Review all records of donor testing for hepatitis C...

  11. 21 CFR 610.48 - Hepatitis C virus (HCV) “lookback” requirements based on review of historical testing records.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Hepatitis C virus (HCV) âlookbackâ requirements... STANDARDS Testing Requirements for Communicable Disease Agents § 610.48 Hepatitis C virus (HCV) “lookback... the following actions: (1) You must: (i) Review all records of donor testing for hepatitis C...

  12. 21 CFR 610.48 - Hepatitis C virus (HCV) “lookback” requirements based on review of historical testing records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Hepatitis C virus (HCV) âlookbackâ requirements... STANDARDS Testing Requirements for Communicable Disease Agents § 610.48 Hepatitis C virus (HCV) “lookback... the following actions: (1) You must: (i) Review all records of donor testing for hepatitis C...

  13. 42 CFR 405.1006 - Amount in controversy required to request an ALJ hearing and judicial review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Amount in controversy required to request an ALJ... (Part A and Part B) Alj Hearings § 405.1006 Amount in controversy required to request an ALJ hearing and judicial review. (a) Definitions. For the purposes of aggregating claims to meet the amount in...

  14. NESC Review of the 8-Foot High Temperature Tunnel (HTT) Oxygen Storage Pressure Vessel Inspection Requirements

    NASA Technical Reports Server (NTRS)

    Gilbert, Michael; Raju, Ivatury; Piascik, Robert; Cameron, Kenneth; Kirsch, Michael; Hoffman, Eric; Murthy, Pappu; Hopson, George; Greulich, Owen; Frazier, Wayne

    2009-01-01

    The 8-Foot HTT (refer to Figure 4.0-1) is used to conduct tests of air-breathing hypersonic propulsion systems at Mach numbers 4, 5, and 7. Methane, Air, and LOX are mixed and burned in a combustor to produce test gas stream containing 21 percent by volume oxygen. The NESC was requested by the NASA LaRC Executive Safety Council to review the rationale for a proposed change to the recertification requirements, specifically the internal inspection requirements, of the 8-Foot HTT LOX Run Tank and LOX Storage Tank. The Run Tank is an 8,000 gallon cryogenic tank used to provide LOX to the tunnel during operations, and is pressured during the tunnel run to 2,250 pounds per square inch gage (psig). The Storage Tank is a 25,000 gallon cryogenic tank used to store LOX at slightly above atmospheric pressure as a external shell, with space between the shells maintained under vacuum conditions.

  15. Review of Staphylococcus aureus infections requiring admission to a paediatric intensive care unit

    PubMed Central

    Miles, F; Voss, L; Segedin, E; Anderson, B

    2005-01-01

    Aims: To review clinical features and outcome of children with severe Staphylococcus aureus sepsis (SAS) presenting to a paediatric intensive care unit (PICU) with particular focus on ethnicity, clinical presentation, cardiac involvement, and outcome. Methods: Retrospective chart review of patients coded for SAS over 10 years (October 1993 to April 2004). Results: There were 58 patients identified with SAS over the 10 year study period; 55 were community acquired. This accounted for 4% of hospital admissions for SAS over this time; children with staphylococcal illness comprised 1% of all admissions to the PICU. Maori and Pacific children with SAS were overly represented in the PICU (81%) from a paediatric population where they contribute 21.6%. Musculoskeletal symptoms (79%) dominated presentation rather than isolated pneumonia (10%). An aggressive search for foci and surgical drainage of infective foci was required in 50% of children. Most children had multifocal disease (67%) and normal cardiac valves (95%); the few children (12%) presenting with methicillin resistant S aureus (MRSA) had community acquired infection. The median length of stay in the PICU was 3 (mean 5.8, SD 7.6, range 1–44) days. The median length of stay in hospital was 15 (mean 21, SD 22.7, range 2–149) days. Mortality due to SAS was 8.6% (95% CI 1.4–15.8%) compared with the overall mortality for the PICU of 6% (95% CI 5.3–6.7%). Ten children had significant morbidity after discharge. Conclusions: Community acquired SAS affects healthy children, is multifocal, and has high morbidity and mortality, in keeping with the high severity of illness scores on admission. It is imperative to look for sites of dissemination and to drain and debride foci. Routine echocardiography had low yield in the absence of pre-existing cardiac lesions, persisting fever, or persisting bacteraemia. PMID:16301556

  16. Transfusion interventions in critical bleeding requiring massive transfusion: a systematic review.

    PubMed

    McQuilten, Zoe K; Crighton, Gemma; Engelbrecht, Sunelle; Gotmaker, Robert; Brunskill, Susan J; Murphy, Michael F; Wood, Erica M

    2015-04-01

    Critical bleeding (CB) requiring massive transfusion (MT) can occur in a variety of clinical contexts and is associated with substantial mortality and morbidity. In 2011, the Australian National Blood Authority (NBA) published patient blood management guidelines for CB and MT, which found limited high-quality evidence from which only 2 recommendations could be made. The aim of this systematic review (SR) was to update these guidelines and identify evidence gaps still to be addressed. A comprehensive search was performed for randomized controlled trials (RCTs) and SRs using MeSH index and free text terms in MEDLINE, the Cochrane Library (Issue 11, 2012), EMBASE, CINHAL, PUBMED, and the Transfusion Evidence Library up to July 15, 2014. The evidence was grouped according to 4 questions based on the original guideline relating to transfusion interventions: (1) effect of dose, timing, and ratio of red blood cells (RBCs) to component therapy on patient outcomes; (2) effect of RBC transfusion on patient outcomes; (3) effect of fresh frozen plasma, platelet, cryoprecipitate, fibrinogen concentrate, and prothrombin complex concentrate on patient outcomes; and (4) effect of recombinant activated factor VII (rFVIIa) on patient outcomes. From this search, 19 studies were identified: 6 RCTs and 13 SRs. Two of the RCTs were pilot/feasibility studies, 3 were investigating rFVIIa, and 1 compared restrictive versus liberal RBC transfusion in upper gastrointestinal hemorrhage. Overall, limited new evidence was identified and substantial evidence gaps remain, particularly with regard to the effect of component therapies, including ratio of RBC to component therapies, on patient outcomes. Clinical trials to address these questions are required. PMID:25716645

  17. Salmonella enterica serovar Typhimurium strain lacking pmrG-HM-D provides excellent protection against salmonellosis in murine typhoid model.

    PubMed

    Negi, Vidya Devi; Singhamahapatra, Santanu; Chakravortty, Dipshikha

    2007-07-20

    The superiority of live attenuated vaccines in systemic salmonellosis has been proven over killed and subunit vaccines, because of its ability to induce protective cell mediated immunity by CD8+ T cells. A live attenuated Salmonella enterica serovar Typhimurium vaccine has been developed by systematic site directed deletion of the pmrG-HM-D chromosomal genomic loci. This gene confers involved in antimicrobial peptide resistance and is involved in LPS modification, both of which are the major immune evasive mechanisms in Salmonella. The efficacy of the newly developed strain in inducing protection against mortality after challenge with the virulent wild type Salmonella typhimurium 12023 was evaluated in mice model of typhoid fever. Animals were immunized and then boosted on days 7 and 14. Following challenge with virulent S. typhimurium 12023, organ burden and mortality of vaccinated mice were less compared to non-immunized controls. The vaccine strain also induced elevated CD8+ T cells in the vaccinated mice. This multiple mutant vaccine candidate appears to be safe for use in pregnant mice and provides a model for the development of live vaccine candidates against naturally occurring salmonellosis and typhoid fever. PMID:17574312

  18. Reviews.

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 1988

    1988-01-01

    Reviews two computer programs: "Molecular Graphics," which allows molecule manipulation in three-dimensional space (requiring IBM PC with 512K, EGA monitor, and math coprocessor); and "Periodic Law," a database which contains up to 20 items of information on each of the first 103 elements (Apple II or IBM PC). (MVL)

  19. 77 FR 73611 - Notice of Public Information Collection Requirements Submitted to OMB for Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... delivery, by which we mean systematic review of the operation of a program compared to a set of explicit or... OMB for Review SUMMARY: U.S. Agency for International Development (USAID) has submitted the following information collection to OMB for review and clearance under the Paperwork Reduction Act of 1995, Public...

  20. The Female Post-Mating Response Requires Genes Expressed in the Secondary Cells of the Male Accessory Gland in Drosophila melanogaster.

    PubMed

    Sitnik, Jessica L; Gligorov, Dragan; Maeda, Robert K; Karch, François; Wolfner, Mariana F

    2016-03-01

    Seminal proteins from the Drosophila male accessory gland induce post-mating responses (PMR) in females. The PMR comprise behavioral and physiological changes that include increased egg laying, decreased receptivity to courting males, and changes in the storage and use of sperm. Many of these changes are induced by a "sex peptide" (SP) and are maintained by SP's binding to, and slow release from, sperm. The accessory gland contains two secretory cell types with distinct morphological and developmental characteristics. Products of these "main" and "secondary" cells work interdependently to induce and maintain the PMR. To identify individual genes needed for the morphology and function of secondary cells, we studied iab-6(cocu) males, whose secondary cells have abnormal morphology and fail to provide products to maintain the PMR. By RNA-seq, we identified 77 genes that are downregulated by a factor of >5× in iab-6(cocu) males. By functional assays and microscopy, we tested 20 candidate genes and found that at least 9 are required for normal storage and release of SP in mated females. Knockdown of each of these 9 genes consequently leads to a reduction in egg laying and an increase in receptivity over time, confirming a role for the secondary cells in maintaining the long-term PMR. Interestingly, only 1 of the 9 genes, CG3349, encodes a previously reported seminal fluid protein (Sfp), suggesting that secondary cells may perform essential functions beyond the production and modification of known Sfps. At least 3 of the 9 genes also regulate the size and/or abundance of secondary cell vacuoles, suggesting that the vacuoles' contents may be important for the machinery used to maintain the PMR. PMID:26746709

  1. A Review of Realizing the Universal Health Coverage (UHC) Goals by 2030: Part 1- Status quo, Requirements, and Challenges.

    PubMed

    Hussein, Rada

    2015-07-01

    This paper is the first part of a review of how to realize the Universal Health Coverage (UHC) goals by 2030. The objective of this review is to investigate the role of eHealth and technology in achieving UHC, focusing on four aspects: 1) identifying the importance of UHC and highlighting how UHC is influenced by health systems and eHealth, 2) investigating the current status of UHC worldwide and indicating the current challenges facing the realization of UHC, 3) reviewing the current research activities in the UHC domain and emphasizing the role of eHealth and technology in achieving UHC, and 4) discussing the results of the review to identify the current gaps in UHC implantation and the corresponding research lines for future investigation.This part covers the first two aspects through: providing the required background on UHC, highlighting the potential benefits of eHealth utilization in UHC, addressing the current status quo of UHC implementation worldwide, and finally concluding the lessons learned in terms of the UHC challenges and requirements.This part also described the used search methodology and selection criteria to synthesize this review. It also indicates the limitations of conducting a systematic review in this early stage of deploying UHC-oriented eHealth solutions. PMID:26044850

  2. 48 CFR 801.602-73 - Review requirements for scarce medical specialist contracts and contracts for health-care resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... scarce medical specialist contracts and contracts for health-care resources. 801.602-73 Section 801.602... Responsibilities 801.602-73 Review requirements for scarce medical specialist contracts and contracts for health-care resources. For contracts to be awarded under the authority of either 38 U.S.C. 7409 or 38...

  3. Graduation Requirements Review. A Brief to the Ministry of Education from the British Columbia Teachers' Federation

    ERIC Educational Resources Information Center

    British Columbia Teachers' Federation, 2012

    2012-01-01

    Public schools are places where all students are welcomed and supported in their learning. Making changes to the Graduation Program should reinforce and support students' opportunities to learn and grow. In reviewing the current graduation requirements for the province of British Columbia (BC), the British Columbia Teachers' Federation…

  4. 40 CFR 51.914 - What new source review requirements apply for 8-hour ozone nonattainment areas?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... apply for 8-hour ozone nonattainment areas? 51.914 Section 51.914 Protection of Environment... OF IMPLEMENTATION PLANS Provisions for Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.914 What new source review requirements apply for 8-hour ozone nonattainment areas?...

  5. Direct Loan System Requirements: Checklist for Reviewing Systems under the Federal Financial Management Improvement Act. Financial Management Series.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Accounting and Information Management Div.

    This checklist reflects the requirements of the revised Direct Loan System of the Joint Financial Management Improvement Program to assist agencies in implementing and monitoring their direct loan system and to help managers and auditors review their direct loan systems to determine if they comply with the Federal Financial Management Improvement…

  6. 21 CFR 111.113 - What quality control operations are required for a material review and disposition decision?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... material review and disposition decision? 111.113 Section 111.113 Food and Drugs FOOD AND DRUG... Production and Process Control System: Requirements for Quality Control § 111.113 What quality control... accordance with § 111.70 is not met; (2) A batch deviates from the master manufacturing record,...

  7. 40 CFR 51.914 - What new source review requirements apply for 8-hour ozone nonattainment areas?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OF IMPLEMENTATION PLANS Provisions for Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.914 What new source review requirements apply for 8-hour ozone nonattainment areas? The... apply for 8-hour ozone nonattainment areas? 51.914 Section 51.914 Protection of...

  8. 40 CFR 51.914 - What new source review requirements apply for 8-hour ozone nonattainment areas?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... OF IMPLEMENTATION PLANS Provisions for Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.914 What new source review requirements apply for 8-hour ozone nonattainment areas? The... apply for 8-hour ozone nonattainment areas? 51.914 Section 51.914 Protection of...

  9. 40 CFR 51.914 - What new source review requirements apply for 8-hour ozone nonattainment areas?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OF IMPLEMENTATION PLANS Provisions for Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.914 What new source review requirements apply for 8-hour ozone nonattainment areas? The... apply for 8-hour ozone nonattainment areas? 51.914 Section 51.914 Protection of...

  10. 77 FR 54567 - Submission for OMB Review; Comment Request: Requirements for Baby-Bouncers and Walker-Jumpers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ..., 2012 (77 FR 3700), the Consumer Product Safety Commission (CPSC or Commission) published a notice in... COMMISSION Submission for OMB Review; Comment Request: Requirements for Baby-Bouncers and Walker-Jumpers... baby-bouncers and walker-jumpers in regulations codified at 16 CFR 1500.18(a)(6) and 1500.86(a)(4)....

  11. 15 CFR 930.3 - Review of the implementation of the federal consistency requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT FEDERAL CONSISTENCY WITH APPROVED COASTAL MANAGEMENT.... As part of the responsibility to conduct a continuing review of approved management programs, the Director of the Office of Ocean and Coastal Resource Management (Director) shall review the performance...

  12. Decisions required for operating a maternal mortality review committee: the California experience.

    PubMed

    Main, Elliott K

    2012-02-01

    Maternal mortality is a current and important issue for obstetrics. The challenge is to structure case reviews so that they develop real data that can inform and direct quality improvement activities. In this article, we describe a series of decisions we have made in California to organize and run our maternal mortality review committee. These include defining the goal of the reviews, selection of cases, composition of the committee, basic review issues, and the definitions used for analysis (eg, cause of death, contributing factors, role of cesarean delivery, preventability, identifying quality improvement opportunities). It is expected that each maternal mortality review committee will have somewhat different approaches based on local resources and case mix. PMID:22280864

  13. Thermo-Oxidative Stability of Graphite/PMR-15 Composites: Effect of Fiber Surface Modification on Composite Shear Properties

    NASA Technical Reports Server (NTRS)

    Madhukar, Madhu S.; Bowles, Kenneth J.; Papadopolous, Demetrios S.

    1994-01-01

    Experiments were conducted to establish a correlation between the weight loss of a polyimide (PMR- 15) matrix and graphite fibers and the in-plane shear properties of their unidirectional composites subjected to different isothermal aging times up to 1000 hr at 316 C. The role of fiber surface treatment on the composite degradation during the thermo-oxidative aging was investigated by using A4 graphite fibers with three surface modifications: untreated (AU-4), surface treated (AS-4), and surface treated and sized with an epoxy-compatible sizing (AS-4G). The weight loss of the matrix fibers, and composites was determined during the aging. The effect of thermal aging was seen in all the fiber samples in terms of weight loss and reduction in fiber diameter. Calculated values of weight loss fluxes for different surfaces of rectangular unidirectional composite plates showed that the largest weight loss occurred at those cut surfaces where fibers were perpendicular to the surface. Consequently, the largest amount of damage was also noted on these cut surfaces. Optical observation of the neat matrix and composite plates subjected to different aging times revealed that the degradation (such as matrix microcracking and void growth) occurred in a thin surface layer near the specimen edges. The in-plane shear modulus of the composites was unaffected by the fiber surface treatment and the thermal aging. The shear strength of the composites with the untreated fibers was the lowest and it decreased with aging. A fracture surface examination of the composites with untreated fibers suggested that the weak interface allowed the oxidation reaction to proceed along the interface and thus expose the inner material to further oxidation. The results indicated that the fiber-matrix interface affected the composite degradation process during its thermal aging and that the the weak interface accelerated the composite degradation.

  14. Early Physical Rehabilitation in the ICU: A Review for the Neurohospitalist

    PubMed Central

    Mendez-Tellez, Pedro A.; Nusr, Rasha; Feldman, Dorianne; Needham, Dale M.

    2012-01-01

    Advances in critical care have resulted in improved intensive care unit (ICU) mortality. However, improved ICU survival has resulted in a growing number of ICU survivors living with long-term sequelae of critical illness, such as impaired physical function and quality of life (QOL). In addition to critical illness, prolonged bed rest and immobility may lead to severe physical deconditioning and loss of muscle mass and muscle weakness. ICU-acquired weakness is associated with increased duration of mechanical ventilation and weaning, longer ICU and hospital stay, and increased mortality. These physical impairments may last for years after ICU discharge. Early Physical Medicine and Rehabilitation (PM&R) interventions in the ICU may attenuate or prevent the weakness and physical impairments occurring during critical illness. This article reviews the evidence regarding safety, feasibility, barriers, and benefits of early PM&R interventions in ICU patients and discusses the limited existing data on early PM&R in the neurological ICU and future directions for early PM&R in the ICU. PMID:23983871

  15. Report of the US Nuclear Regulatory Commission Piping Review Committee. Volume 2. Evaluation of seismic designs: a review of seismic design requirements for Nuclear Power Plant Piping

    SciTech Connect

    Not Available

    1985-04-01

    This document reports the position and recommendations of the NRC Piping Review Committee, Task Group on Seismic Design. The Task Group considered overlapping conservation in the various steps of seismic design, the effects of using two levels of earthquake as a design criterion, and current industry practices. Issues such as damping values, spectra modification, multiple response spectra methods, nozzle and support design, design margins, inelastic piping response, and the use of snubbers are addressed. Effects of current regulatory requirements for piping design are evaluated, and recommendations for immediate licensing action, changes in existing requirements, and research programs are presented. Additional background information and suggestions given by consultants are also presented.

  16. 48 CFR 801.602-72 - Exceptions and additional review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... review of all proposed contracts with hotels or similar facilities for conferences or similar functions... conference at a particular hotel is a procurement and procurement laws and regulations must be followed....

  17. 48 CFR 801.602-72 - Exceptions and additional review requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... review of all proposed contracts with hotels or similar facilities for conferences or similar functions... conference at a particular hotel is a procurement and procurement laws and regulations must be followed....

  18. Submittal Requirements for Review of Planning, Bidding and Construction Documents for Georgia Public Schools.

    ERIC Educational Resources Information Center

    Georgia State Dept. of Education, Atlanta. Facilities Services Unit.

    This document presents the Georgia Department of Education's submittal requirements for documents addressing the planning and construction of educational facilities. Requirements cover such areas as project funding sources, copies and format, site plan, floor plans, elevations and sections, construction delivery method, and heating, air…

  19. 76 FR 78662 - Agency Recordkeeping/Reporting Requirements Under Emergency Review by the Office of Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ... training and data grants are governed by the ``new grant'' PI and the basic grant is governed by the ``basic grant'' PI. Current PIs require separate applications and program assessment reports for each... by consolidating the PIs into one single PI and requiring one single, consolidated application...

  20. 24 CFR 1000.20 - Is an Indian tribe required to assume environmental review responsibilities?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... evaluation of the environmental issues and take responsibility for the scope and content of the EA in... responsibilities, HUD will perform the environmental review in accordance with 24 CFR part 50. The timing of HUD.... (c) Where an environmental assessment (EA) is appropriate under 24 CFR part 50, instead of an...

  1. 24 CFR 1000.20 - Is an Indian tribe required to assume environmental review responsibilities?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... evaluation of the environmental issues and take responsibility for the scope and content of the EA in... responsibilities, HUD will perform the environmental review in accordance with 24 CFR part 50. The timing of HUD.... (c) Where an environmental assessment (EA) is appropriate under 24 CFR part 50, instead of an...

  2. 24 CFR 1000.20 - Is an Indian tribe required to assume environmental review responsibilities?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... evaluation of the environmental issues and take responsibility for the scope and content of the EA in... responsibilities, HUD will perform the environmental review in accordance with 24 CFR part 50. The timing of HUD.... (c) Where an environmental assessment (EA) is appropriate under 24 CFR part 50, instead of an...

  3. 24 CFR 1000.20 - Is an Indian tribe required to assume environmental review responsibilities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... evaluation of the environmental issues and take responsibility for the scope and content of the EA in... responsibilities, HUD will perform the environmental review in accordance with 24 CFR part 50. The timing of HUD.... (c) Where an environmental assessment (EA) is appropriate under 24 CFR part 50, instead of an...

  4. 42 CFR 488.64 - Remote facility variances for utilization review requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... such facility or direct responsibility for the care of the patients being reviewed or, in the case of a... requesting facility will use, if a variance is granted, to assure: (1) That effective and timely control will... improve the quality of care provided to patients. (f) The request for a variance shall include: (1)...

  5. 42 CFR 488.64 - Remote facility variances for utilization review requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... such facility or direct responsibility for the care of the patients being reviewed or, in the case of a... requesting facility will use, if a variance is granted, to assure: (1) That effective and timely control will... improve the quality of care provided to patients. (f) The request for a variance shall include: (1)...

  6. 42 CFR 488.64 - Remote facility variances for utilization review requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... such facility or direct responsibility for the care of the patients being reviewed or, in the case of a... requesting facility will use, if a variance is granted, to assure: (1) That effective and timely control will... improve the quality of care provided to patients. (f) The request for a variance shall include: (1)...

  7. 42 CFR 488.64 - Remote facility variances for utilization review requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... such facility or direct responsibility for the care of the patients being reviewed or, in the case of a... requesting facility will use, if a variance is granted, to assure: (1) That effective and timely control will... improve the quality of care provided to patients. (f) The request for a variance shall include: (1)...

  8. 76 FR 38183 - Agency Recordkeeping/Reporting Requirements Under Emergency Review by the Office of Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... Under Emergency Review by the Office of Management and Budget (OMB) Title: Evaluation of Adolescent... Training 533 1 .7 373 Princeton Center for Leadership Training (PCLT)/ 533 1 .6 320 TeenPEP Total 2468 1601... Officer for ACF, Office of Management and Budget, Paperwork Reduction Project, 725 17th Street...

  9. Transverse flexural tests as a tool for assessing damage to PMR-15 composites from isothermal aging in air at elevated temperatures

    NASA Technical Reports Server (NTRS)

    Bowles, Kenneth J.

    1992-01-01

    To date, the effect of thermo-oxidative aging on unidirectional composite mechanical properties has been monitored by the measurement of interlaminar shear strength (ILSS) and either three or four point longitudinal flexural strength (LFS) of the composites being tested. Both results are affected by the fiber-to-matrix bonding, the former being dependent on the shear resistance of the interface and the latter on the degree of load sharing by the fibers through the fiber/matrix interface. Recently, fiber/matrix interfacial bond strengths have been monitored using a transverse flexural strength (TFS) test method. This test method was used to evaluate the effect of fiber surface treatment on the fiber/matrix bond. The interface bonding was varied in these tests using Hercules A-fibers with three-types of surfaces that produce bonds of poor, better, and good quality. The TFS was found not only to be sensitive to the bonding, but also to the aging time of unidirectional A-fiber/PMR-15 composites. This relationship reflects the mechanism by which the PMR-15 degrades during thermal aging.

  10. Reviews

    NASA Astrophysics Data System (ADS)

    2001-11-01

    BOOK REVIEW Search for Life BOOK REVIEW Health Physics BOOK REVIEW Language and Literacy in Science Education BOOK REVIEW Science Web Reader—Physics Correction GCSE BOOK REVIEW Physics for Higher Tier GCSE BOOK REVIEW Modular Science GCSE BOOK REVIEW Modular Science for AQA: Foundation level and Higher level GCSE BOOK REVIEW Physics for OCR A GCSE BOOK REVIEW Physics Matters, 3rd edition GCSE BOOK REVIEW Physics GCSE BOOK REVIEW Science Foundations: Physics (new edition) GCSE BOOK REVIEW Target Science: Physics Foundation Tier GCSE BOOK REVIEW Target Science: Physics Foundation Tier: AQA WEB WATCH Medical physics organizations

  11. Tax-exempt hospitals and community benefits: a review of state reporting requirements.

    PubMed

    Hellinger, Fred Joseph

    2009-02-01

    In June 2007 the Internal Revenue Service proposed a major overhaul of its reporting requirements for tax-exempt hospitals and released draft Form 990 (the IRS form filed by tax-exempt organizations each year). In December 2007 the IRS promulgated the final Form 990 after incorporating some of the recommendations made in the almost seven hundred public comments on the discussion draft. One recommendation adopted in the final Form 990 is the postponement until tax year 2009 (returns filed in 2010) of the requirement for hospitals to submit detailed information on the percentage of total expenses attributable to charity care, unreimbursed Medicaid costs, and community-health improvement programs (the discussion draft required this information for tax year 2007). Although the IRS will not require tax-exempt hospitals to provide detailed information about community benefits until the 2009 tax year, sixteen states have laws requiring tax-exempt hospitals to enumerate the benefits that they provide to the community. Information about the impact of these laws on the provision of community benefits (e.g., charity and uncompensated care) is examined in this study whose primary purpose is to highlight information policy makers may glean from states that have adopted community-benefit reporting laws. PMID:19234293

  12. 12 CFR 615.5255 - Disclosure and review requirements for other equities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) All of the information required by part 620 of this chapter in the annual report to shareholders as of... recent annual report to shareholders and the most recent quarterly report filed with the FCA in... subsequent transferee acquires at least $250,000 of the stock and meets the definition of...

  13. 78 FR 14095 - Agency Recordkeeping/Reporting Requirements Under Emergency Review by the Office of Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ... Administration for Children and Families' (ACF) 196 form for periodic financial reporting under the Temporary... required by Congress. Financial reporting under the TANF program is governed by 45 CFR part 265. This... HUMAN SERVICES Administration for Children and Families Agency Recordkeeping/Reporting...

  14. 48 CFR 215.407-5-70 - Disclosure, maintenance, and review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... estimates for total cost or a major cost element(s) that do not provide an acceptable basis for negotiation...) Definitions. (1) Acceptable estimating system is defined in the clause at 252.215-7002, Cost Estimating System... in the clause at 252.215-7002, Cost Estimating System Requirements. (4) Significant estimating...

  15. 75 FR 81273 - Public Information Collection Requirement Submitted to OMB for Review and Approval, Comments...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ...The Federal Communications Commission, as part of its continuing effort to reduce paperwork burden invites the general public and other Federal agencies to take this opportunity to comment on the following information collection(s), as required by the Paperwork Reduction Act (PRA) of 1995, 44 U.S.C. 3501-3520. Comments are requested concerning (a) Whether the proposed collection of information......

  16. 76 FR 79688 - Agency Recordkeeping/Reporting Requirements Under Emergency Review by the Office of Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    ... HUMAN SERVICES Administration for Children and Families Agency Recordkeeping/Reporting Requirements... U.S. Department of Health and Human Services (HHS) have launched a national evaluation called the... characteristics including: The type of home visiting model, geography, urbanicity, target population, and...

  17. A Template for Spiritual Assessment: A Review of the JCAHO Requirements and Guidelines for Implementation

    ERIC Educational Resources Information Center

    Hodge, David R.

    2006-01-01

    Growing consensus exists regarding the importance of spiritual assessment. For instance, the largest health care accrediting body in the United States, the Joint Commission on Accreditation of Healthcare Organizations (JCAHO), now requires the administration of a spiritual assessment. Although most practitioners endorse the concept of spiritual…

  18. 44 CFR 10.8 - Determination of requirement for environmental review.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Agency actions (see 40 CFR 1508.18) significantly (see 40 CFR 1508.27) affecting the quality of the human... emergency. (d) Categorical Exclusions (CATEXs). CEQ regulations at 40 CFR 1508.4 provide for the categorical... requirements of 44 CFR 60.6(c) under the National Flood Insurance Program; (xv) Repair,...

  19. 44 CFR 10.8 - Determination of requirement for environmental review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Agency actions (see 40 CFR 1508.18) significantly (see 40 CFR 1508.27) affecting the quality of the human... emergency. (d) Categorical Exclusions (CATEXs). CEQ regulations at 40 CFR 1508.4 provide for the categorical... requirements of 44 CFR 60.6(c) under the National Flood Insurance Program; (xv) Repair,...

  20. 44 CFR 10.8 - Determination of requirement for environmental review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Agency actions (see 40 CFR 1508.18) significantly (see 40 CFR 1508.27) affecting the quality of the human... emergency. (d) Categorical Exclusions (CATEXs). CEQ regulations at 40 CFR 1508.4 provide for the categorical... requirements of 44 CFR 60.6(c) under the National Flood Insurance Program; (xv) Repair,...

  1. 44 CFR 10.8 - Determination of requirement for environmental review.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Agency actions (see 40 CFR 1508.18) significantly (see 40 CFR 1508.27) affecting the quality of the human... emergency. (d) Categorical Exclusions (CATEXs). CEQ regulations at 40 CFR 1508.4 provide for the categorical... requirements of 44 CFR 60.6(c) under the National Flood Insurance Program; (xv) Repair,...

  2. 44 CFR 10.8 - Determination of requirement for environmental review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Agency actions (see 40 CFR 1508.18) significantly (see 40 CFR 1508.27) affecting the quality of the human... emergency. (d) Categorical Exclusions (CATEXs). CEQ regulations at 40 CFR 1508.4 provide for the categorical... requirements of 44 CFR 60.6(c) under the National Flood Insurance Program; (xv) Repair,...

  3. 75 FR 65296 - Notice of Public Information Collection Requirements Submitted to OMB for Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... INFORMATION: OMB Number: OMB 0412-New. Form Number: AID 321-2. Title: Mentor Prot g Program--Annual Report. Type of Submission: New Information Collection. Purpose: The mentors are required to report on the progress made under each active Mentor-Prot g Agreement annually throughout the term of the agreement....

  4. 78 FR 40443 - Submission for OMB Review; Comment Request-Recordkeeping Requirements Under the Safety Standard...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... for Infant Walkers AGENCY: Consumer Product Safety Commission. ACTION: Notice. SUMMARY: In the Federal Register of April 19, 2013 (76 FR 23544), the Consumer Product Safety Commission (CPSC or Commission... the recordkeeping requirements in the safety standard for infant walkers, 16 CFR part 1216....

  5. 76 FR 7145 - Notice of Public Information Collection Requirements Submitted to OMB for Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-09

    ... FR 66724) and is being republished. Unfortunately, it appears that supporting documentation sent to...; ] AGENCY FOR INTERNATIONAL DEVELOPMENT Notice of Public Information Collection Requirements Submitted to... increase in the cost of living. U.S. Agency for International Development (USAID) has resubmitted...

  6. 21 CFR 320.30 - Inquiries regarding bioavailability and bioequivalence requirements and review of protocols by...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Drugs strongly recommends that, to avoid the conduct of an improper study and unnecessary human research... inquiries relating to in vivo bioavailability requirements and methodology shall be submitted to the Food and Drug Administration, Center for Drug Evaluation and Research, Office of Clinical...

  7. 21 CFR 320.30 - Inquiries regarding bioavailability and bioequivalence requirements and review of protocols by...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Drugs strongly recommends that, to avoid the conduct of an improper study and unnecessary human research... inquiries relating to in vivo bioavailability requirements and methodology shall be submitted to the Food and Drug Administration, Center for Drug Evaluation and Research, Office of Clinical...

  8. 77 FR 66464 - Federal Acquisition Regulation; Submission for OMB Review; Value Engineering Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-05

    ... published in the Federal Register at 77 FR 43076, on July 23, 2012. No comments were received. Public... Register at 77 FR 43076, on July 23, 2012. Respondents: 1,934. Responses per Respondent: 2. Annual...., Washington, DC 20417. ATTN: Hada Flowers/IC 9000-0027, Value Engineering Requirements. Instructions:...

  9. Soil erosion and sediment control laws. A review of state laws and their natural resource data requirements

    NASA Technical Reports Server (NTRS)

    Klein, S. B.

    1980-01-01

    Twenty states, the District of Columbia, and the Virgin Islands enacted erosion and sediment control legislation during the past decade to provide for the implementation or the strengthening of statewide erosion and sediment control plans for rural and/or urban lands. That legislation and the state programs developed to implement these laws are quoted and reviewed. The natural resource data requirements of each program are also extracted. The legislation includes amendments to conservation district laws, water quality laws, and erosion and sediment control laws. Laws which provides for legislative review of administrative regulations and LANDSAT applications and/or information systems that were involved in implementing or gathering data for a specific soil erosion and sediment control program are summarized as well as principal concerns affecting erosion and sediment control laws.

  10. Review of photochemical reaction constants of organic micropollutants required for UV advanced oxidation processes in water.

    PubMed

    Wols, B A; Hofman-Caris, C H M

    2012-06-01

    Emerging organic contaminants (pharmaceutical compounds, personal care products, pesticides, hormones, surfactants, fire retardants, fuel additives etc.) are increasingly found in water sources and therefore need to be controlled by water treatment technology. UV advanced oxidation technologies are often used as an effective barrier against organic contaminants. The combined operation of direct photolysis and reaction with hydroxyl radicals ensures good results for a wide range of contaminants. In this review, an overview is provided of the photochemical reaction parameters (quantum yield, molar absorption, OH radical reaction rate constant) of more than 100 organic micropollutants. These parameters allow for a prediction of organic contaminant removal by UV advanced oxidation systems. An example of contaminant degradation is elaborated for a simplified UV/H(2)O(2) system. PMID:22483836

  11. The role of elastic energy in activities with high force and power requirements: a brief review.

    PubMed

    Wilson, Jacob M; Flanagan, Eamonn P

    2008-09-01

    The purpose of this article is to provide strength and conditioning practitioners with an understanding of the role of elastic energy in activities with high force and power requirements. Specifically, the article covers 1) the nature of elasticity and its application to human participants, 2) the role of elastic energy in activities requiring a stretch-shorten cycle such as the vertical jump, 3) the role of muscular stiffness in athletic performance, 4) the control of muscular stiffness through feedforward and feedback mechanisms, and 5) factors affecting muscular stiffness. Finally, practical applications are provided. In this section, it is suggested that the storage and reuse of elastic energy is optimized at relatively higher levels of stiffness. Because stiffness decreases as fatigue ensues as well as with stretching before an event, the article emphasizes the need for proper preparation phases in a periodized cycle and the avoidance of long static stretches before high-force activities. The importance of teaching athletes to transition from eccentric to concentric movements with minimal time delays is also proposed due to the finding that time delays appear to decrease the reuse of elastic energy. In addition to teaching within the criterion tasks, evidence is provided that minimizing transitions in plyometric training, a technique demonstrated to increase musculotendinous stiffness, can optimize power output in explosive movements. Finally, evidence is provided that training and teaching programs designed to optimize muscular stiffness may protect athletes against sports-related injuries. PMID:18714212

  12. Review of the post-weld heat treatment requirements for offshore structures

    SciTech Connect

    Stacey, A.

    1994-12-31

    The guidance of the United Kingdom Health and Safety Executive (HSE) on the design and construction of offshore structures recommends that post-weld heat treatment (PWHT) be carried out on welded joints exceeding specified thickness limits. This is based on test data which have shown that as-welded joints of thicker material are susceptible to failure by brittle fracture at -10 C, the typical design temperature for exposed parts of structures in the North Sea. However, PWHT may be dispensed with, subject to the agreement of the certifying authority, if it can be demonstrated by fracture mechanics assessment methods that the structure is fit-for-purpose in the as-welded condition. In recent years, there has been an increasing trend in the offshore industry towards the use of the fitness-for-purpose approach. This is due to the growing awareness of the benefits that can be derived from taking this approach, enabled by the development of improved fracture mechanics assessment methods and of weld procedures and materials which have resulted in welds with improved fracture toughness. As a consequence, increasing amounts of structure that would otherwise have required PWHT have been left in the as-welded condition. This paper examines the PWHT requirements in the light of these trends.

  13. Getting published well requires fulfilling editors' and reviewers' needs and desires.

    PubMed

    Schoenwolf, Gary C

    2013-12-01

    Publication in international scientific journals provides an unparalleled opportunity for authors to showcase their work. Where authors publish affects how the community values the work. This value directly determines the impact of the work on the field-papers must be read and cited to advance the field, and because the scientific literature is vast, only a subset of the literature is widely read and cited. Moreover, the value placed on the work also affects the authors' scientific reputation and career advancement. Consequently, it is essential that manuscripts receive the recognition they deserve by being published in one of the "best" journals that the scientific findings allow. Several factors determine where a paper is published: how well the topic of the paper fits the scope of the journal, the quality of the study and the manuscript describing it, the advance the paper makes in its field, the importance of the advance, and the extent to which the paper impacts the broader community of science. As scientists, we assume that our papers will be assessed objectively using only well defined scientific standards, but editors and reviewers also view papers subjectively, having biases of what defines a high-quality publication based on Western standards. Therefore, scientists trained in other parts of the world can be significantly disadvantaged in getting their papers published in the best journals. Here, I present concrete suggestions for improving the perception of a paper in the reader's minds, increasing the likelihood that it will get published well. PMID:24131034

  14. Long-term Isothermal Aging Effects on Weight Loss, Compression Properties, and Dimensions of T650-35 Fabric-reinforced PMR-15 Composites-data

    NASA Technical Reports Server (NTRS)

    Bowles, Kenneth J.; Tsuji, Luis; Kamvouris, John; Roberts, Gary D.

    2003-01-01

    A cooperative program was conducted with the General Electric Aircraft Engines plant in Evendale, Ohio, to study the effects of long-term isothermal aging at elevated temperatures on compression and thermal durability properties of T650 35 fabric-reinforced PMR 15 composites. This degradation study was conducted over an approximate time period of 3 1/2 yr. The aging temperatures were 204, 260, 288, 316, and 343 C. Specimens of different dimensions were evaluated. Specimens with ratios of the cut edge to total surface area of 0.03 to 0.89 were fabricated and aged. The aged and unaged specimens were tested in compression as specified in Test Method for Compressive Properties of Rigid Plastics (ASTM D695M). Thickness changes, degraded surface layer growth, weight loss, and failure modes were monitored and recorded. All property changes were thickness dependent.

  15. A Review of Engine Seal Performance and Requirements for Current and Future Army Engine Platforms

    NASA Technical Reports Server (NTRS)

    Delgado, Irebert R.; Proctor, Margaret P.

    2008-01-01

    Sand ingestion continues to impact combat ground and air vehicles in military operations in the Middle East. The T-700 engine used in Apache and Blackhawk helicopters has been subjected to increased overhauls due to sand and dust ingestion during desert operations. Engine component wear includes compressor and turbine blades/vanes resulting in decreased engine power and efficiency. Engine labyrinth seals have also been subjected to sand and dust erosion resulting in tooth tip wear, increased clearances, and loss in efficiency. For the current investigation, a brief overview is given of the history of the T-700 engine development with respect to sand and dust ingestion requirements. The operational condition of labyrinth seals taken out of service from 4 different locations of the T-700 engine during engine overhauls are examined. Collaborative efforts between the Army and NASA to improve turbine engine seal leakage and life capability are currently focused on noncontacting, low leakage, compliant designs. These new concepts should be evaluated for their tolerance to sand laden air. Future R&D efforts to improve seal erosion resistance and operation in desert environments are recommended

  16. A review of the kinetic detail required for accurate predictions of normal shock waves

    NASA Technical Reports Server (NTRS)

    Muntz, E. P.; Erwin, Daniel A.; Pham-Van-diep, Gerald C.

    1991-01-01

    Several aspects of the kinetic models used in the collision phase of Monte Carlo direct simulations have been studied. Accurate molecular velocity distribution function predictions require a significantly increased number of computational cells in one maximum slope shock thickness, compared to predictions of macroscopic properties. The shape of the highly repulsive portion of the interatomic potential for argon is not well modeled by conventional interatomic potentials; this portion of the potential controls high Mach number shock thickness predictions, indicating that the specification of the energetic repulsive portion of interatomic or intermolecular potentials must be chosen with care for correct modeling of nonequilibrium flows at high temperatures. It has been shown for inverse power potentials that the assumption of variable hard sphere scattering provides accurate predictions of the macroscopic properties in shock waves, by comparison with simulations in which differential scattering is employed in the collision phase. On the other hand, velocity distribution functions are not well predicted by the variable hard sphere scattering model for softer potentials at higher Mach numbers.

  17. International requirements for consent in biobank research: qualitative review of research guidelines.

    PubMed

    Hirschberg, Irene; Kahrass, Hannes; Strech, Daniel

    2014-12-01

    Several stakeholders in the field of biobank research are currently developing and evaluating innovative consent procedures, and in doing so refer to national and international guidelines that regulate biomedical research. The objectives of this study were to present (1) a synthesis of all consent issues mentioned or required in guidelines that are of potential relevance to biobank research and (2) a detailed overview of similarities and differences between these guidelines. This analysis considered a purposive sample of the nine most internationally recognised research guidelines plus a national checklist for developing consent forms. The synthesis of all included research guidelines found 41 issues of potential relevance to consent procedures in biobank research. The guidelines differ substantially with respect to (1) how comprehensively they address these consent issues, (2) their definition and explanation of the issues and (3) how directly or indirectly the issues are mentioned. The set of 41 consent issues presented in this paper should be further developed in a continuous process. Our findings on the differences among major research guidelines also raise the issue of a more systematic development and revision process for these guidelines. The presented set of content issues potentially relevant to consent in biobank research can inform the balanced development or evaluation of consent forms, as well as the development and revision of corresponding research guidelines. PMID:25351952

  18. Reviews

    NASA Astrophysics Data System (ADS)

    2001-07-01

    A-LEVEL RESOURCES REVIEWS SPECIAL AS and A2 books and resources: deciding what to buy? SUMMARY Exam boards, specifications and support materials OCR (Oxford Cambridge and RSA Examinations) CORRECTION BOOK REVIEW Good Practice in Science Teaching WEB WATCH Astronomy and cosmology DVD REVIEW The Video Encyclopedia of Physics Demonstrations SOFTWARE REVIEW Graph Paper Printer

  19. Reviews

    NASA Astrophysics Data System (ADS)

    2003-07-01

    CD REVIEWS (346) Spectrum 7 Physics - Waves SOFTWARE REVIEW (347) Sound Packages BOOK REVIEW (350) Measured Tones, 2nd edition WEB WATCH (351) What’s the frequency, Kenneth? BOOK REVIEW (354) We know what you did last summer ... now do something better this summer

  20. Reviews

    NASA Astrophysics Data System (ADS)

    2001-03-01

    CD-ROM REVIEWS SPECIAL: Multimedia CD-ROMs WEB WATCH: Medical imaging BOOK REVIEW: Understanding Science Lessons CD-ROM REVIEWS SPECIAL Multimedia CD-ROMs: what do they offer to enhance physics teaching? PEAR: Physics Exercises for Assessment and Revision GCSE Physics 1998 33 72 Contact: Europress WEB WATCH Medical imaging BOOK REVIEW Understanding Science Lessons

  1. NRC review of Electric Power Research Institute`s advanced light water reactor utility requirements document. Passive plant designs, chapter 1, project number 669

    SciTech Connect

    Not Available

    1994-08-01

    The Electric Power Research Institute (EPRI) is preparing a compendium of technical requirements, referred to as the {open_quotes}Advanced Light Water Reactor [ALWR] Utility Requirements Document{close_quotes}, that is acceptable to the design of an ALWR power plant. When completed, this document is intended to be a comprehensive statement of utility requirements for the design, construction, and performance of an ALWR power plant for the 1990s and beyond. The Requirements Document consists of three volumes. Volume 1, {open_quotes}ALWR Policy and Summary of Top-Tier Requirements{close_quotes}, is a management-level synopsis of the Requirements Document, including the design objectives and philosophy, the overall physical configuration and features of a future nuclear plant design, and the steps necessary to take the proposed ALWR design criteria beyond the conceptual design state to a completed, functioning power plant. Volume II consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant [approximately 1350 megawatts-electric (MWe)]. Volume III contains utility design requirements for nuclear plants for which passive features will be used in their designs (approximately 600 MWe). In April 1992, the staff of the Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, issued Volume 1 and Volume 2 (Parts 1 and 2) of its safety evaluation report (SER) to document the results of its review of Volumes 1 and 2 of the Requirements Document. Volume 1, {open_quotes}NRC Review of Electric Power Research Institute`s Advanced Light Water Reactor Utility Requirements Document - Program Summary{close_quotes}, provided a discussion of the overall purpose and scope of the Requirements Document, the background of the staff`s review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review.

  2. NRC review of Electric Power Research Institute`s advanced light water reactor utility requirements document. Passive plant designs, chapters 2-13, project number 669

    SciTech Connect

    Not Available

    1994-08-01

    The Electric Power Research Institute (EPRI) is preparing a compendium of technical requirements, referred to as the {open_quotes}Advanced Light Water Reactor [ALWR] Utility Requirements Document{close_quotes}, that is acceptable to the design of an ALWR power plant. When completed, this document is intended to be a comprehensive statement of utility requirements for the design, construction, and performance of an ALWR power plant for the 1990s and beyond. The Requirements Document consists of three volumes. Volume I, {open_quotes}ALWR Policy and Summary of Top-Tier Requirements{close_quotes}, is a management-level synopsis of the Requirements Document, including the design objectives and philosophy, the overall physical configuration and features of a future nuclear plant design, and the steps necessary to take the proposed ALWR design criteria beyond the conceptual design state to a completed, functioning power plant. Volume II consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant [approximately 1350 megawatts-electric (MWe)]. Volume III contains utility design requirements for nuclear plants for which passive features will be used in their designs (approximately 600 MWe). In April 1992, the staff of the Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, issued Volume 1 and Volume 2 (Parts 1 and 2) of its safety evaluation report (SER) to document the results of its review of Volumes 1 and 2 of the Requirements Document. Volume 1, {open_quotes}NRC Review of Electric Power Research Institute`s Advanced Light Water Reactor Utility Requirements Document - Program Summary{close_quotes}, provided a discussion of the overall purpose and scope of the Requirements Document, the background of the staff`s review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review.

  3. Reviews

    ERIC Educational Resources Information Center

    Schodde, P.; Ed.

    1976-01-01

    Reviews 17 books and curriculum materials of interest to secondary science teachers. Topics include plant science, pollution, fishes, science investigations, general zoology, neurobiology, electronics, and the environment. (MLH)

  4. REVIEW ARTICLE: Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes

    NASA Astrophysics Data System (ADS)

    Dunn, Warwick B.

    2008-03-01

    The functional levels of biological cells or organisms can be separated into the genome, transcriptome, proteome and metabolome. Of these the metabolome offers specific advantages to the investigation of the phenotype of biological systems. The investigation of the metabolome (metabolomics) has only recently appeared as a mainstream scientific discipline and is currently developing rapidly for the study of microbial, plant and mammalian metabolomes. The metabolome pipeline or workflow encompasses the processes of sample collection and preparation, collection of analytical data, raw data pre-processing, data analysis and data storage. Of these processes the collection of analytical data will be discussed in this review with specific interest shown in the application of mass spectrometry in the metabolomics pipeline. The current developments in mass spectrometry platforms (GC-MS, LC-MS, DIMS and imaging MS) and applications of specific interest will be highlighted. The current limitations of these platforms and applications will be discussed with areas requiring further development also highlighted. These include the detectable coverage of the metabolome, the identification of metabolites and the process of converting raw data to biological knowledge.

  5. Reviews.

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 1988

    1988-01-01

    Reviews three computer software packages for Apple II computers. Includes "Simulation of Hemoglobin Function,""Solution Equilibrium Problems," and "Thin-Layer Chromatography." Contains ratings of ease of use, subject matter content, pedagogic value, and student reaction according to two separate reviewers for each program. (CW)

  6. Reviews

    NASA Astrophysics Data System (ADS)

    2002-09-01

    CD-ROM REVIEWS (449) It's Physics Furry Elephant: Electricity Explained BOOK REVIEWS (450) What Are the Chances? Voodoo Deaths, Office Gossip and Other Adventures in Probability Dictionary of Mechanics: A handbook for teachers and students Intermediate 2 Physics PLACES TO VISIT (452) Spaceguard Centre WEB WATCH (455) Risk

  7. Reviews

    NASA Astrophysics Data System (ADS)

    2004-01-01

    BOOK REVIEWS (99) Complete A-Z Physics Handbook Science Magic in the Kitchen The Science of Cooking Science Experiments You Can Eat WEB WATCH (101) These journal themes are pasta joke Microwave oven Web links CD REVIEW (104) Electricity and Magnetism, KS3 Big Science Comics

  8. The effect of contact stresses in four-point bend testing of graphite/epoxy and graphite/PMR-15 composite beams

    NASA Technical Reports Server (NTRS)

    Binienda, Wieslaw K.; Roberts, Gary D.; Papadopoulos, Demetrios S.

    1992-01-01

    The results of in-plane four-point bend experiments on unidirectionally reinforced composite beams are presented for graphite/epoxy (T300/934) and graphite/polyimide (G30-500/PMR-15) composites. The maximum load and the location of cracks formed during failure were measured for testpieces with fibers oriented at various angles to the beam axis. Since most of the beams failed near one or more of the load points, the strength of the beams was evaluated in terms of a proposed model, for the local stress distribution. In this model, an exact solution to the problem of a localized contact force acting on a unidirectionally reinforced half plane is used to describe the local stress field. The stress singularity at the load points is treated in a manner similar to the stress singularity at a crack tip in fracture mechanisms problems. Using this approach, the effect of fiber angle and elastic material properties on the strength of the beam is described in terms of a load intensity factor. For fiber angles less than 45 deg from the beam axis, a single crack is initiated near one of the load points at a critical value of the load intensity factor. The critical load intensity factor decreases with the increasing fiber angle. For larger fiber angles, multiple cracks occur at locations both near and away from the load points, and the load intensity factor at failure increases sharply with increasing fiber angle.

  9. Properties of M40J Carbon/PMR-II-50 Composites Fabricated with Desized and Surface Treated Fibers. Characterization of M40J Desized and Finished Fibers

    NASA Technical Reports Server (NTRS)

    Allred, Ronald E.; Gosau, Jan M.; Shin, E. Eugene; McCorkle, Linda S.; Sutter, James K.; OMalley, Michelle; Gray, Hugh R. (Technical Monitor)

    2002-01-01

    To increase performance and durability of high temperature composites for potential rocket engine components, it is necessary to optimize wetting and interfacial bonding between high modulus carbon fibers and high temperature polyimide resins. It has been previously demonstrated that the electro-oxidative shear treatments used by fiber manufacturers are not effective on higher modulus fibers that have fewer edge and defect sites in the surface crystallites. In addition, sizings commercially supplied on most carbon fibers are not compatible with polyimides. This study was an extension of prior work characterizing the surface chemistry and energy of high modulus carbon fibers (M40J and M60J, Torray) with typical fluorinated polyimide resins, such as PMR-II-50. A continuous desizing system which utilizes environmentally friendly chemical- mechanical processes was developed for tow level fiber and the processes were optimized based on weight loss behavior, surface elemental composition (XPS) and morphology (FE-SEM) analyses, and residual tow strength of the fiber, and the similar approaches have been applied on carbon fabrics. Both desized and further treated with a reactive finish were investigated for the composite reinforcement. The effects of desizing and/or subsequent surface retreatment on carbon fiber on composite properties and performance including fiber-matrix interfacial mechanical properties, thermal properties and blistering onset behavior will be discussed in this presentation.

  10. Effect of contact stresses in four-point bend testing of graphite/epoxy and graphite/PMR-15 composite beams

    NASA Technical Reports Server (NTRS)

    Binienda, W. K.; Roberts, G. D.; Papadopoulos, D. S.

    1992-01-01

    The results of in-plane four-point bend experiments on unidirectionally reinforced composite beams are presented for graphite/epoxy (T300/934) and graphite/polyimide (G30-500/PMR-15) composites. The maximum load and the location of cracks formed during failure were measured for testpieces with fibers oriented at various angles to the beam axis. Since most of the beams failed near one or more of the load points, the strength of the beams was evaluated in terms of a proposed model for the local stress distribution. In this model, an exact solution to the problem of a localized contact force acting on a unidirectionally reinforced half plane is used to describe the local stress field. The stress singularity at the load points is treated in a manner similar to the stress singularity at a crack tip in fracture mechanisms problems. Using this approach, the effect of fiber angle and elastic material properties on the strength of the beam is described in terms of a load intensity factor. For fiber angles less than 45 deg from the beam axis, a single crack is initiated near one of the load points at a critical value of the load intensity factor. The critical load intensity factor decreases with increasing fiber angle. For larger fiber angles, multiple cracks occur at locations both near and away from the load points, and the load intensity factor at failure increases sharply with increasing fiber angle.

  11. Review of the Constellation Level II Safety, Reliability, and Quality Assurance (SR&QA) Requirements Documents during Participation in the Constellation Level II SR&QA Forum

    NASA Technical Reports Server (NTRS)

    Cameron, Kenneth D.; Gentz, Steven J.; Beil, Robert J.; Minute, Stephen A.; Currie, Nancy J.; Scott, Steven S.; Thomas, Walter B., III; Smiles, Michael D.; Schafer, Charles F.; Null, Cynthia H.; Bay, P. Michael

    2009-01-01

    At the request of the Exploration Systems Mission Directorate (ESMD) and the Constellation Program (CxP) Safety, Reliability; and Quality Assurance (SR&QA) Requirements Director, the NASA Engineering and Safety Center (NESC) participated in the Cx SR&QA Requirements forum. The Requirements Forum was held June 24-26; 2008, at GRC's Plum Brook Facility. The forums purpose was to gather all stakeholders into a focused meeting to help complete the process of refining the CxP to refine its Level II SR&QA requirements or defining project-specific requirements tailoring. Element prime contractors had raised specific questions about the wording and intent of many requirements in areas they felt were driving costs without adding commensurate value. NESC was asked to provide an independent and thorough review of requirements that contractors believed were driving Program costs, by active participation in the forum. This document contains information from the forum.

  12. Reviews.

    ERIC Educational Resources Information Center

    Greenleaf, Floyd; And Others

    1986-01-01

    Reviews eight textbooks, readers, and books. Topics include Latin America, colonial America, the Carolinians, women in French textbooks, the Vikings, the Soviet Union, nineteenth-century Black America, and Ernest Rutherford. (TRS)

  13. Reviews.

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 1987

    1987-01-01

    Provides a review of both the Apple and IBM versions of ENZPACK, a software package which is designed to assist in the teaching of enzyme kinetics in courses where this topic is treated in some depth. (TW)

  14. Reviews.

    ERIC Educational Resources Information Center

    Science Teacher, 1988

    1988-01-01

    Reviews four software packages: (1) Agents of Infection; (2) The Earth Science Series; (3) Investigating Electric Fields; and (4) Aquatic Biology-PC. Describes the hardware needed, bibliographic data and specific details of the programs themselves. (CW)

  15. Reviews.

    ERIC Educational Resources Information Center

    Science Teacher, 1988

    1988-01-01

    Reviews four software packages available for IBM PC or Apple II. Includes "Graphical Analysis III"; "Space Max: Space Station Construction Simulation"; "Guesstimation"; and "Genetic Engineering Toolbox." Focuses on each packages' strengths in a high school context. (CW)

  16. Reviews.

    ERIC Educational Resources Information Center

    Science Teacher, 1987

    1987-01-01

    Provides reviews of four computer software packages designed for use in science education. Describes courseware dealing with a variety of tips for teaching physics concepts, chemical reactions in an aqueous solution, mitosis and meiosis, and photosynthesis. (TW)

  17. 24 CFR 570.901 - Review for compliance with the primary and national objectives and other program requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... requirements of 24 CFR part 91 and the displacement policy requirements at § 570.606; (e) For HUD-administered... requirements of 24 CFR 35.940; (g) The grant administration requirements described in subpart J; (h) Other... pertaining to loan guarantees (subpart M) and urban renewal completions (subpart N)....

  18. 24 CFR 570.901 - Review for compliance with the primary and national objectives and other program requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... requirements of 24 CFR part 91 and the displacement policy requirements at § 570.606; (e) For HUD-administered... requirements of 24 CFR 35.940; (g) The grant administration requirements described in subpart J; (h) Other... pertaining to loan guarantees (subpart M) and urban renewal completions (subpart N)....

  19. 24 CFR 570.901 - Review for compliance with the primary and national objectives and other program requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... requirements of 24 CFR part 91 and the displacement policy requirements at § 570.606; (e) For HUD-administered... requirements of 24 CFR 35.940; (g) The grant administration requirements described in subpart J; (h) Other... pertaining to loan guarantees (subpart M) and urban renewal completions (subpart N)....

  20. 24 CFR 570.901 - Review for compliance with the primary and national objectives and other program requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... requirements of 24 CFR part 91 and the displacement policy requirements at § 570.606; (e) For HUD-administered... requirements of 24 CFR 35.940; (g) The grant administration requirements described in subpart J; (h) Other... pertaining to loan guarantees (subpart M) and urban renewal completions (subpart N)....