Science.gov

Sample records for requirements doe order

  1. Integrating total quality management principles with the requirements of DOE Order 5700.6C

    SciTech Connect

    Hedges, D.

    1993-03-01

    The Department of Energy has recently required its field offices, contractors, and subcontractors to implement DOE Order 5700.6C, ``Quality Assurance,`` for all work on waste management contracts. The order restructures the 18 criteria of NQA-1 and focuses on the role of management in achieving and assuring quality, performance of activities to achieve and assure quality, and management`s assessment of its performance for the purpose of identifying improvements to be made. The DOE order also introduces elements of the total quality management (TQM) philosophy, which were not present in DOE Order 5700.6B. The research community within DOE has recently issued a document entitled DOE Order 5700.6C Implementation Guide, which is more explicit about the integration of TQM principles with the implementation of DOE Order 5700.6C in research facilities. The Environmental Protection Agency is sponsoring a quality assurance standard (ANSI/ASQC E-4) to replace EPA`s QAMS 005/80. The new standard is consistent with DOE Order 5700.6C, and it also stresses the integration of TQM principles within the quality assurance process. This paper discusses the intent and philosophy of the 10 criteria of the new DOE order, the status of ANSI/ASQC E-4, and how to effectively integrate TQM principles into the quality assurance process as the conversion is made from NQA-1 to DOE Order 5700.6C. The purpose and value of DOE Order 5700.6C Implementation Guide for research will also be discussed.

  2. Guidance document on the variance propagation requirements in DOE Order 5633. 3

    SciTech Connect

    Sanborn, J.

    1991-10-01

    DOE facilities handling special nuclear material are required to comply with DOE Order 5633.3, which addresses various aspects of nuclear material accounting. In particular, it requires that control limits be calculated for nuclear material inventory differences. These requirements and methods of meeting them are described. The four steps in this process are the creation of a variance propagation model of the nuclear material accounting system, the validation of the model, the application of the model, and the documentation of the model; the first two of these steps are discussed at length. Topics addressed include: the mathematics of variance propagation, the structure of nuclear material accounting systems, sources of uncertainty in real accounting systems, statistical models of these sources of uncertainty, methods of estimating error standard deviations, calculation of control limits from inventory difference standard deviations, and comparison of models with historical inventory difference data. A chapter is also devoted to calculational methods. The approach emphasizes constructing models that can be implemented relatively easily and improved as data is accumulated and understanding of the system is gained, rather than attempting all-inclusive, highly detailed models at the outset.

  3. Guidance document on the variance propagation requirements in DOE Order 5633.3

    SciTech Connect

    Sanborn, J.

    1991-10-01

    DOE facilities handling special nuclear material are required to comply with DOE Order 5633.3, which addresses various aspects of nuclear material accounting. In particular, it requires that control limits be calculated for nuclear material inventory differences. These requirements and methods of meeting them are described. The four steps in this process are the creation of a variance propagation model of the nuclear material accounting system, the validation of the model, the application of the model, and the documentation of the model; the first two of these steps are discussed at length. Topics addressed include: the mathematics of variance propagation, the structure of nuclear material accounting systems, sources of uncertainty in real accounting systems, statistical models of these sources of uncertainty, methods of estimating error standard deviations, calculation of control limits from inventory difference standard deviations, and comparison of models with historical inventory difference data. A chapter is also devoted to calculational methods. The approach emphasizes constructing models that can be implemented relatively easily and improved as data is accumulated and understanding of the system is gained, rather than attempting all-inclusive, highly detailed models at the outset.

  4. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY BONDING OF SHIP'S PERSONNEL Section 1 What this order does. This order requires that General Agents, appointed under Service Agreement “G.A.A., 3/19/51” shall not...

  5. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY BONDING OF SHIP'S PERSONNEL Section 1 What this order does. This order requires that General Agents, appointed under...

  6. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY BONDING OF SHIP'S PERSONNEL Section 1 What this order does. This order requires that General Agents, appointed under...

  7. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY BONDING OF SHIP'S PERSONNEL Section 1 What this order does. This order requires that General Agents, appointed under...

  8. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY BONDING OF SHIP'S PERSONNEL Section 1 What this order does. This order requires that General Agents, appointed under...

  9. Quality Assurance Grading Guidelines for Research and Development at DOE Facilities (DOE Order 5700.6C)

    SciTech Connect

    Powell, T.B.

    1992-01-01

    The quality assurance (QA) requirements for the U.S. Department of Energy (DOE) are established in DOE Order 5700.6C. This order is applicable for all DOE departmental elements, management, and maintenance and operating contractors and requires that documented Quality Assurance Programs (QAPs) are prepared at all levels; it has one attachment. The DOE Office of Energy Research (DOE-ER) has issued a standard to ensure implementation of the full intent of this order in the ER community.

  10. A PROPOSED FRAMEWORK FOR PLANNING DEACTIVATION AND DECOMMISSIONING ENGINEERING AND DESIGN ACTIVITIES TO MEET THE REQUIREMENTS OF DOE ORDER 413.3A, PROGRAM AND PROJECT MANAGEMENT FOR THE ACQUISITION OF CAPITAL ASSETS

    SciTech Connect

    Santos, J; John Gladden, J

    2007-11-06

    This paper provides guidance in applying the requirements of DOE O 413.3A to Deactivation and Decommissioning (D&D) projects. A list of 41 engineering and design activities relevant to D&D projects was generated. For several activities in this list, examples of the level of development and/or types of deliverables that might be expected at the completion of the conceptual, preliminary and final project design phases described in the Order are provided.

  11. Policy Perspective: Meeting the Challenge of the DOE Order 436.1 Departmental Sustainability - 12527

    SciTech Connect

    MacDonald, Jennifer C.

    2012-07-01

    DOE's Sustainability Performance Office is working to meet sustainability goals at DOE by implementing Executive Orders, Departmental policy, the DOE Strategic Sustainability Performance Plan (SSPP) and legislation related to sustainability. Through implementation of Executive Orders, Departmental policy, the SSPP, statutory requirements and regular reporting, analysis and communication, DOE's SPO is working to maintain and expand DOE's leadership in sustainability. (authors)

  12. Quality assurance grading guidelines for research and development at DOE facilities. DOE Order 5700.6C

    SciTech Connect

    Powell, T.B.; Morris, R.N.

    1992-10-01

    The quality assurance (QA) requirements for the US Department of Energy (DOE) are established in DOE Order 5700.6C. This order is applicable for all DOE departmental elements, management, and maintenance and operating contractors and requires that documented Quality Assurance Programs (QAPS) are prepared at all levels; it has one attachment. The DOE Office of Energy Research (DOE-ER) has issued a standard to ensure implementation of the full intent of this order in the ER community. This report discusses order 5700.6C in relation to research with DOE.

  13. 40 CFR 33.201 - What does this subpart require?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false What does this subpart require? 33.201 Section 33.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... AGENCY PROGRAMS Certification § 33.201 What does this subpart require? (a) In order to qualify...

  14. Review of orders and regulations requiring environmental protection

    SciTech Connect

    Kelly, E.; Cunningham, R.; Michael, D.

    1996-09-01

    With the increased awareness of and interest in potential ecological risks associated with past, current, and future Department of Energy (DOE) activities, DOE`s Defense Programs (DP) Office of Technical and Environmental Support sponsored a study to (1) evaluate the effectiveness of the current compliance-driven environmental protection and assessment efforts relative to ecological concerns; (2) explore the need for a more focused, integrated approach to address ecological impacts; and (3) identify the requirements for an integrated approach. The study explored four questions. (a) Which federal regulations and DOE orders either explicitly require ecological assessments or implicitly require them through environmental protection language? (b) What currently is being done at selected DOE facilities to implement these regulations and orders? (c) What are private sector industries doing in terms of ecological risk assessments and how do industry approaches and issues compare with those of DOE? (d) What, if anything, in addition to current efforts is needed to ensure the protection of ecological resources associated with DOE facilities, to support defensible decision making, and to improve efficiency? The results of this study are presented in a report titled {open_quotes}Integrated, Comprehensive Ecological Impact Assessments In Support of Department of Energy Decision Making{close_quotes}. This report is a companion document to that report. This report provides a more detailed discussion of the document reviews of the relevant environmental protection regulations and current and pending DOE orders. The main goal of the document reviews was to understand existing requirements for ecological data collection and impact assessments.

  15. Simulation Higher Order Language Requirements Study.

    ERIC Educational Resources Information Center

    Goodenough, John B.; Braun, Christine L.

    The definitions provided for high order language (HOL) requirements for programming flight training simulators are based on the analysis of programs written for a variety of simulators. Examples drawn from these programs are used to justify the need for certain HOL capabilities. A description of the general structure and organization of the…

  16. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE TO BE... NSA ORDER NO. 47 Section 1 What this order does. This order prescribes procedures for the...

  17. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE TO BE... NSA ORDER NO. 47 Section 1 What this order does. This order prescribes procedures for the...

  18. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE TO BE... NSA ORDER NO. 47 Section 1 What this order does. This order prescribes procedures for the...

  19. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR... Section 1 What this order does. This order cancels NSA Order No. 32 (SRM-1); and outlines the procedure...

  20. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE TO BE... NSA ORDER NO. 47 Section 1 What this order does. This order prescribes procedures for the...

  1. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY REPATRIATION OF SEAMEN Section 1 What this order does. This order prescribes the manner in which seamen separated from vessels operated for the account of the...

  2. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY LAUNCH SERVICES Section 1 What this order does. This order prescribes the circumstances under which launch hire will be accepted by National Shipping Authority as...

  3. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY AUTHORITY AND RESPONSIBILITY OF GENERAL AGENTS TO UNDERTAKE EMERGENCY REPAIRS IN FOREIGN PORTS Section 1 What this order does. This order outlines General...

  4. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY GENERAL AGENT'S RESPONSIBILITY IN CONNECTION WITH FOREIGN REPAIR CUSTOM'S ENTRIES Section 1 What this order does. This order outlines the procedure to be followed...

  5. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY AUTHORITY AND... AGREEMENT Section 1 What this order does. This order outlines General Agents' limited authority to...

  6. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY AUTHORITY AND... AGREEMENT Section 1 What this order does. This order outlines General Agents' limited authority to...

  7. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY LAUNCH SERVICES Section 1 What this order does. This order prescribes the circumstances under which launch hire will...

  8. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY REPATRIATION OF SEAMEN Section 1 What this order does. This order prescribes the manner in which seamen separated from...

  9. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY LAUNCH SERVICES Section 1 What this order does. This order prescribes the circumstances under which launch hire will...

  10. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY REPATRIATION OF SEAMEN Section 1 What this order does. This order prescribes the manner in which seamen separated from...

  11. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY AUTHORITY AND... AGREEMENT Section 1 What this order does. This order outlines General Agents' limited authority to...

  12. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY REPATRIATION OF SEAMEN Section 1 What this order does. This order prescribes the manner in which seamen separated from...

  13. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY LAUNCH SERVICES Section 1 What this order does. This order prescribes the circumstances under which launch hire will...

  14. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY AUTHORITY AND... AGREEMENT Section 1 What this order does. This order outlines General Agents' limited authority to...

  15. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY LAUNCH SERVICES Section 1 What this order does. This order prescribes the circumstances under which launch hire will...

  16. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR...-WORKSMALREP Section 1 What this order does. This order authorizes the use of NSA-WORKSMALREP...

  17. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY REPATRIATION OF SEAMEN Section 1 What this order does. This order prescribes the manner in which seamen separated from...

  18. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ACCOMPLISHMENT OF SHIP REPAIRS UNDER NATIONAL SHIPPING AUTHORITY INDIVIDUAL CONTRACT FOR MINOR REPAIRS-NSA-WORKSMALREP Section 1 What this order does. This order authorizes the use of NSA-WORKSMALREP...

  19. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ACCOMPLISHMENT OF SHIP REPAIRS UNDER NATIONAL SHIPPING AUTHORITY INDIVIDUAL CONTRACT FOR MINOR REPAIRS-NSA-WORKSMALREP Section 1 What this order does. This order authorizes the use of NSA-WORKSMALREP...

  20. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ACCOMPLISHMENT OF SHIP REPAIRS UNDER NATIONAL SHIPPING AUTHORITY INDIVIDUAL CONTRACT FOR MINOR REPAIRS-NSA-WORKSMALREP Section 1 What this order does. This order authorizes the use of NSA-WORKSMALREP...

  1. Impact assessment of draft DOE Order 5820.2B. Radioactive Waste Technical Support Program

    SciTech Connect

    1995-04-01

    The Department of Energy (DOE) has prepared a revision to DOE Order 5820.2A, entitled ``Radioactive Waste Management.`` DOE issued DOE Order 5820.2A in September 1988 and, as the title implies, it covered only radioactive waste forms. The proposed draft order, entitled ``Waste Management,`` addresses the management of both radioactive and nonradioactive waste forms. It also includes spent nuclear fuel, which DOE does not consider a waste. Waste forms covered include hazardous waste, high-level waste, transuranic (TRU) waste, low-level radioactive waste, uranium and thorium mill tailings, mixed waste, and sanitary waste. The Radioactive Waste Technical Support Program (TSP) of Leached Idaho Technologies Company (LITCO) is facilitating the revision of this order. The EM Regulatory Compliance Division (EM-331) has requested that TSP estimate the impacts and costs of compliance with the revised order. TSP requested Dames & Moore to aid in this assessment by comparing requirements in Draft Order 5820.2B to ones in DOE Order 5820.2A and other DOE orders and Federal regulations. The assessment started with a draft version of 5820.2B dated January 14, 1994. DOE has released three updated versions of the draft order since then (dated May 20, 1994; August 26, 1994; and January 23, 1995). Each time DOE revised the order, Dames and Moore updated the assessment work to reflect the text changes. This report reflects the January 23, 1995 version of the draft order.

  2. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF SHIP REPAIRS UNDER NATIONAL SHIPPING AUTHORITY INDIVIDUAL CONTRACT FOR MINOR REPAIRS-NSA-WORKSMALREP Section 1 What this order does....

  3. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE FOR ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Section 1 What this order does. This...

  4. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY VOYAGE DATA Section 1 What this order does. The General Agents, as appointed by the National Shipping Authority, promulgated under GAA, 3/19/51, shall be instructed in...

  5. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY GENERAL AGENT'S RESPONSIBILITY IN CONNECTION WITH FOREIGN REPAIR CUSTOM'S ENTRIES Section 1 What this order does. This...

  6. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY GENERAL AGENT'S RESPONSIBILITY IN CONNECTION WITH FOREIGN REPAIR CUSTOM'S ENTRIES Section 1 What this order does. This...

  7. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY GENERAL AGENT'S RESPONSIBILITY IN CONNECTION WITH FOREIGN REPAIR CUSTOM'S ENTRIES Section 1 What this order does. This...

  8. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY SLOP CHESTS Section 1 What this order does. In accordance with the provisions of section 11 f the act of Congress...

  9. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY SLOP CHESTS Section 1 What this order does. In accordance with the provisions of section 11 f the act of Congress...

  10. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY VOYAGE DATA Section 1 What this order does. The General Agents, as appointed by the National Shipping Authority,...

  11. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY VOYAGE DATA Section 1 What this order does. The General Agents, as appointed by the National Shipping Authority,...

  12. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY SLOP CHESTS Section 1 What this order does. In accordance with the provisions of section 11 f the act of Congress...

  13. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY VOYAGE DATA Section 1 What this order does. The General Agents, as appointed by the National Shipping Authority,...

  14. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY VOYAGE DATA Section 1 What this order does. The General Agents, as appointed by the National Shipping Authority,...

  15. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY SLOP CHESTS Section 1 What this order does. In accordance with the provisions of section 11 f the act of Congress...

  16. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY GENERAL AGENT'S RESPONSIBILITY IN CONNECTION WITH FOREIGN REPAIR CUSTOM'S ENTRIES Section 1 What this order does. This...

  17. ALTHOUGH SOUTHERN DUCTILE DOES NOT OWN PATTERNS, THEY ARE REQUIRED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ALTHOUGH SOUTHERN DUCTILE DOES NOT OWN PATTERNS, THEY ARE REQUIRED TO STORE THEM AND KEEP THEM AVAILABLE FOR THEIR CUSTOMERS ORDERS. THE BARRET/DOUGLAS LIFTING TRUCK IS USED TO REACH AND TRANSPORT PATTERNS. - Southern Ductile Casting Company, Mold Making, 2217 Carolina Avenue, Bessemer, Jefferson County, AL

  18. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Section 1 What this order does. This order cancels NSA Order No. 32 (SRM-1); and outlines the procedure to... repairs under the National Shipping Authority Master Repair Contract, NSA-LUMPSUMREP. The Coast...

  19. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Section 1 What this order does. This order cancels NSA Order No. 32 (SRM-1); and outlines the procedure to... repairs under the National Shipping Authority Master Repair Contract, NSA-LUMPSUMREP. The Coast...

  20. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Section 1 What this order does. This order cancels NSA Order No. 32 (SRM-1); and outlines the procedure to... repairs under the National Shipping Authority Master Repair Contract, NSA-LUMPSUMREP. The Coast...

  1. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY PROCEDURE TO BE FOLLOWED BY GENERAL AGENTS IN PREPARATION OF INVOICES AND PAYMENT OF COMPENSATION PURSUANT TO PROVISIONS OF NSA ORDER NO. 47 Section 1 What this order...

  2. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY SLOP CHESTS Section 1 What this order does. In accordance with the provisions of section 11 f the act of Congress approved June 26, 1884, 23 Stat. 56; 46 U.S.C. 670,...

  3. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY AUTHORITY AND RESPONSIBILITY OF GENERAL AGENTS TO UNDERTAKE EMERGENCY REPAIRS IN FOREIGN PORTS Section 1 What this order...

  4. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY AUTHORITY AND RESPONSIBILITY OF GENERAL AGENTS TO UNDERTAKE EMERGENCY REPAIRS IN FOREIGN PORTS Section 1 What this order...

  5. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY AUTHORITY AND RESPONSIBILITY OF GENERAL AGENTS TO UNDERTAKE EMERGENCY REPAIRS IN FOREIGN PORTS Section 1 What this order...

  6. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY AUTHORITY AND RESPONSIBILITY OF GENERAL AGENTS TO UNDERTAKE EMERGENCY REPAIRS IN FOREIGN PORTS Section 1 What this order...

  7. Planned revision to DOE Order 5820.2A, Radioactive Waste Management

    SciTech Connect

    Duggan, G.J.; Williams, R.E.; Kudera, D.E.; Bailey, D.E.

    1993-03-01

    US Department of Energy Headquarters initiated efforts to revise DOE Order 5820.2A, ``Radioactive Waste Management``. The purpose of the revision is to enhance DOE waste management requirements, reflect new DOE organizational responsibilities, and consolidate requirements for management of all waste, under the responsibility of Environmental Restoration and Waste Management, into a single order. This paper discusses the revision philosophy, objectives of the revision, and strategy for the revision. Issues being considered for inclusion in the revision and recommended methods of resolving each issue are also discussed.

  8. 21 CFR 1305.21 - Requirements for electronic orders.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Requirements for electronic orders. 1305.21... I AND II CONTROLLED SUBSTANCES Electronic Orders § 1305.21 Requirements for electronic orders. (a) To be valid, the purchaser must sign an electronic order for a Schedule I or II controlled...

  9. 21 CFR 1305.21 - Requirements for electronic orders.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Requirements for electronic orders. 1305.21... I AND II CONTROLLED SUBSTANCES Electronic Orders § 1305.21 Requirements for electronic orders. (a) To be valid, the purchaser must sign an electronic order for a Schedule I or II controlled...

  10. 21 CFR 1305.21 - Requirements for electronic orders.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Requirements for electronic orders. 1305.21... I AND II CONTROLLED SUBSTANCES Electronic Orders § 1305.21 Requirements for electronic orders. (a) To be valid, the purchaser must sign an electronic order for a Schedule I or II controlled...

  11. 21 CFR 1305.21 - Requirements for electronic orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Requirements for electronic orders. 1305.21... I AND II CONTROLLED SUBSTANCES Electronic Orders § 1305.21 Requirements for electronic orders. (a) To be valid, the purchaser must sign an electronic order for a Schedule I or II controlled...

  12. 21 CFR 1305.21 - Requirements for electronic orders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Requirements for electronic orders. 1305.21... I AND II CONTROLLED SUBSTANCES Electronic Orders § 1305.21 Requirements for electronic orders. (a) To be valid, the purchaser must sign an electronic order for a Schedule I or II controlled...

  13. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY AUTHORITY AND RESPONSIBILITY OF GENERAL AGENTS TO UNDERTAKE IN CONTINENTAL UNITED STATES PORTS VOYAGE REPAIRS AND SERVICE EQUIPMENT OF VESSELS OPERATED FOR THE ACCOUNT...

  14. Fluor Daniel Hanford implementation plan for DOE Order 5480.28, Natural phenomena hazards mitigation

    SciTech Connect

    Conrads, T.J.

    1997-09-12

    Natural phenomena hazards (NPH) are unexpected acts of nature that pose a threat or danger to workers, the public, or the environment. Earthquakes, extreme winds (hurricane and tornado), snow, flooding, volcanic ashfall, and lightning strikes are examples of NPH that could occur at the Hanford Site. U.S. Department of Energy (DOE) policy requires facilities to be designed, constructed, and operated in a manner that protects workers, the public, and the environment from hazards caused by natural phenomena. DOE Order 5480.28, Natural Phenomena Hazards Mitigation, includes rigorous new natural phenomena criteria for the design of new DOE facilities, as well as for the evaluation and, if necessary, upgrade of existing DOE facilities. The Order was transmitted to Westinghouse Hanford Company in 1993 for compliance and is also identified in the Project Hanford Management Contract, Section J, Appendix C. Criteria and requirements of DOE Order 5480.28 are included in five standards, the last of which, DOE-STD-1023, was released in fiscal year 1996. Because the Order was released before all of its required standards were released, enforcement of the Order was waived pending release of the last standard and determination of an in-force date by DOE Richland Operations Office (DOE-RL). Agreement also was reached between the Management and Operations Contractor and DOE-RL that the Order would become enforceable for new structures, systems, and components (SSCS) 60 days following issue of a new order-based design criteria in HNF-PRO-97, Engineering Design and Evaluation. The order also requires that commitments addressing existing SSCs be included in an implementation plan that is to be issued 1 year following the release of the last standard. Subsequently, WHC-SP-1175, Westinghouse Hanford Company Implementation Plan for DOE Order 5480.28, Natural Phenomena Hazards Mitigation, Rev. 0, was issued in November 1996, and this document, HNF-SP-1175, Fluor Daniel Hanford

  15. Construction safety management guide for use with DOE Order 440.1

    SciTech Connect

    1997-06-26

    DOE Order (DOE O) 440.1, Worker Protection Management for DOE Federal and Contractor Employees, establishes the framework for an effective worker protection program to reduce or eliminate accidental losses, injuries, and illnesses by providing workers with places of employment free of recognized hazards. In addition to prescribing program requirements applicable to all activities performed by DOE and its contractors, DOE O 440.1 provides specific requirements applicable only to construction activities. The intent of these construction-specific requirements is to compel the proactive management of construction safety on a project-by-project basis and, to the greatest extent possible, integrate the management of safety and health, both in terms of project personnel and management methodologies, with the management of the other primary elements of construction project performance: quality, cost and schedule.

  16. DOE Order 5480.28 Hanford facilities database

    SciTech Connect

    Hayenga, J.L., Westinghouse Hanford

    1996-09-01

    This document describes the development of a database of DOE and/or leased Hanford Site Facilities. The completed database will consist of structure/facility parameters essential to the prioritization of these structures for natural phenomena hazard vulnerability in compliance with DOE Order 5480.28, `Natural Phenomena Hazards Mitigation`. The prioritization process will be based upon the structure/facility vulnerability to natural phenomena hazards. The ACCESS based database, `Hanford Facilities Site Database`, is generated from current Hanford Site information and databases.

  17. DOE Order 5820.2A implementation status, progress and problems

    SciTech Connect

    Waldo, L.C.; Shepard, M.D.; Wilhite, E.L.

    1989-11-01

    The Department of Energy`s Order governing management of radioactive waste, DOE Order 5820.2A, was revised effective September 26, 1988. Chapter III of the Order contains prescriptive requirements for managing low-level waste. These requirements ensure that all DOE low-level radioactive and mixed waste will be managed in a systematic manner to achieve required performance., The Order defines performance objectives for low-level waste management to limit the dose received by the general public from waste operations, to protect groundwater resources, and to protect inadvertent intruders. For low-level waste disposal operations, the Order requires that a radiological performance assessment be prepared to demonstrate compliance with the performance objectives. The Order also requires that the radiological performance assessments be reviewed by a Peer Review Panel, established by the Order. This paper will summarize the requirements for radioactive waste management and discuss the degree of compliance achieved to date. The Department`s preliminary schedule and anticipated cost to achieve full compliance with the requirements will also be discussed.

  18. 20 CFR 639.2 - What does WARN require?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false What does WARN require? 639.2 Section 639.2 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR WORKER ADJUSTMENT AND RETRAINING NOTIFICATION § 639.2 What does WARN require? WARN requires employers who are planning a...

  19. 40 CFR 141.503 - What does subpart T require?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false What does subpart T require? 141.503 Section 141.503 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS... Fewer Than 10,000 People General Requirements § 141.503 What does subpart T require? There are...

  20. 20 CFR 639.2 - What does WARN require?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false What does WARN require? 639.2 Section 639.2 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR WORKER ADJUSTMENT AND RETRAINING NOTIFICATION § 639.2 What does WARN require? WARN requires employers who are planning a...

  1. 20 CFR 639.2 - What does WARN require?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false What does WARN require? 639.2 Section 639.2 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR WORKER ADJUSTMENT AND RETRAINING NOTIFICATION § 639.2 What does WARN require? WARN requires employers who are planning a...

  2. 20 CFR 639.2 - What does WARN require?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false What does WARN require? 639.2 Section 639.2 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR WORKER ADJUSTMENT AND RETRAINING NOTIFICATION § 639.2 What does WARN require? WARN requires employers who are planning a...

  3. 40 CFR 141.503 - What does subpart T require?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false What does subpart T require? 141.503 Section 141.503 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS... Fewer Than 10,000 People General Requirements § 141.503 What does subpart T require? There are...

  4. 20 CFR 639.2 - What does WARN require?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What does WARN require? 639.2 Section 639.2 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR WORKER ADJUSTMENT AND RETRAINING NOTIFICATION § 639.2 What does WARN require? WARN requires employers who are planning a...

  5. 40 CFR 33.301 - What does this subpart require?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false What does this subpart require? 33.301 Section 33.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... AGENCY PROGRAMS Good Faith Efforts § 33.301 What does this subpart require? A recipient, including...

  6. 40 CFR 33.401 - What does this subpart require?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false What does this subpart require? 33.401 Section 33.401 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... AGENCY PROGRAMS Fair Share Objectives § 33.401 What does this subpart require? A recipient must...

  7. Implementation strategies for U.S. DOE Order 5480.28 Natural Phenomena Hazards Mitigation

    SciTech Connect

    Conrads, T.J.

    1995-01-01

    This paper describes the strategies used by Westinghouse Hanford Company for implementing a new U.S. Department of Energy Order 5480.28, Natural Phenomena Hazards Mitigation. The order requires that all new and existing structures, systems, and components be designed and evaluated for the effects of natural phenomena (seismic, wind, flood, and volcano) applicable at a given site. It also requires that instrumentation be available to record the expected seismic events and that procedures be available to inspect facilities for damage following a natural phenomena event. This order requires that probabilistic hazards studies be conducted for the applicable natural phenomena to determine appropriate loads to be applied in a graded approach to structures, systems, and components important to safety. This paper discusses the processes, tasks, and methods used to implement this directive, which altered the standard design basis for new and existing structures, systems, and components at the Hanford Site. It also addresses a correlation between the performance category nomenclature of DOE Order 5480.28 and the safety classification described in DOE Order 5480.23, Nuclear Safety Analysis Reports. This correlation was deemed to be a prerequisite for the cost-effective implementation of the new DOE Order on natural phenomena hazards mitigation.

  8. Level-ordering does not constrain children's ungrammatical compounds.

    PubMed

    Nicoladis, Elena; Murphy, Victoria A

    2004-01-01

    English-speaking children typically avoid using regular plurals in novel grammatical deverbal compounds as in rat eater but allow irregular plurals as in mice eater (Gordon, 19985). To explain these data, it has been argued that level-ordering model constrains the production of morphologically complex words, including those with which children have had little to no experience. If level-ordering can be supported, children should avoid regular plurals in their ungrammatical deverbal compounds like a breaker-bottle. Seventy-two English-speaking children were included in the present study, 36 from Britain and 36 from Canada. The results showed that 50% of the children who produced ungrammatical compounds included regular plurals in the compounds they produced. Conversely, none of the children who produced grammatical compounds included regular plurals. These results indicate that level-ordering does not constrain children's production of ungrammatical compounds. These results raise the possibility that level-ordering may not be a valid constraint of children's compounding in general. PMID:15172565

  9. What Math Knowledge Does Teaching Require?

    ERIC Educational Resources Information Center

    Thames, Mark Hoover; Ball, Deborah Loewenberg

    2010-01-01

    No one would argue with the claim that teaching mathematics requires mathematics knowledge. However, a clear description of such knowledge needed for teaching has been surprisingly elusive. To differentiate teachers' levels of mathematical knowledge, numerous studies have examined whether a teacher has a certification in math or a degree as well…

  10. Does perceptual learning require consciousness or attention?

    PubMed

    Meuwese, Julia D I; Post, Ruben A G; Scholte, H Steven; Lamme, Victor A F

    2013-10-01

    , suggesting that the memory trace that is formed during inattention is latent until accessed. The results suggest that learning requires consciousness, and not attention, and further strengthen the idea that consciousness is separate from attention. PMID:23691987

  11. 2006 Update for Implementing Best Available Technology per DOE Order 5400.5

    SciTech Connect

    Michael G. Lewis

    2007-09-01

    In accordance with Contract Data Requirements List F.19, this report addresses the Best Available Technology requirements per Department of Energy (DOE) Order 5400.5, “Radiation Protection of the Public and the Environment,” as they apply to radiological discharges to the soil for Calendar Year 2006. The report includes review of discharges for both, Battelle Energy Alliance, LLC and CH2M WG Idaho, LLC. The Best Available Technology selection process is applicable to wastewater discharges containing process derived radionuclides to surface waters, sanitary sewerages greater than five times the Derived Concentration Guideline (found in DOE Order 5400.5), and to the soil. Wastewater at the Idaho National Laboratory Site is not discharged to surface water (Big Lost River and Birch Creek) nor is it discharged to sanitary sewerages at activity levels greater than five times a Derived Concentration Guideline. Therefore, this report focuses on radiological discharges to the soil.

  12. Hazard categorization and accident analysis techniques for compliance with DOE Order 5480.23, Nuclear Safety Analysis Reports

    SciTech Connect

    1992-12-31

    The purpose of this DOE Standard is to establish guidance for facility managers and Program Secretarial Officers (PSOs) and thereby help them to comply consistently and more efficiently with the requirements of DOE Order 5480.23, Nuclear Safety Analysis Reports. To this end, this guidance provides the following practical information: (1) The threshold quantities of radiological material inventory below which compliance with DOE Order 5480.23 is not required. (2) The level of effort to develop the program plan and schedule required in Section 9.b. (2) of the Order, and information for making a preliminary assessment of facility hazards. (3) A uniform methodology for hazard categorization under the Order. (4) Insight into the ''graded approach'' for SAR development, especially in hazard assessment and accident analysis techniques. Individual PSOs may develop additional guidance addressing safety requirements for facilities which fall below the threshold quantities specified in this document.

  13. Assessment of documentation requirements under DOE 5481. 1, Safety Analysis and Review System (SARS)

    SciTech Connect

    Browne, E.T.

    1981-03-01

    This report assesses the requirements of DOE Order 5481.1, Safety Analysis and Review System for DOE Operations (SARS) in regard to maintaining SARS documentation. Under SARS, all pertinent details of the entire safety analysis and review process for each DOE operation are to be traceable from the initial identification of a hazard. This report is intended to provide assistance in identifying the points in the SARS cycle at which documentation is required, what type of documentation is most appropriate, and where it ultimately should be maintained.

  14. 2005 Update for Implementing Best Available Technology per DOE Order 5400.5

    SciTech Connect

    INL

    2006-09-01

    The report addresses Best Available Technology per DOE Order 5400.5 in relation to wastewater discharges to the soil. In accordance with Contract Data Requirements List F.19, this report addresses the Best Available Technology requirements per Department of Energy (DOE) Order 5400.5, "Radiation Protection of the Public and the Environment", as they apply to radiological discharges to the soil for Calendar Year 2005. The report includes review of discharges for both, Battelle Energy Alliance, LLC and CH2M WG Idaho, LLC. The Best Available Technology selection process is applicable to wastewater discharges containing process derived radionuclides to surface waters, sanitary sewerages greater than five times the Derived Concentration Guideline (found in DOE Order 5400.5), and to the soil. Wastewater at the Idaho National Laboratory Site is not discharged to surface water (Big Lost River and Birch Creek) nor is it discharged to sanitary sewerages at activity levels greater than five times a Derived Concentration Guideline. Therefore, this report focuses on radiological discharges to the soil.

  15. 40 CFR 33.201 - What does this subpart require?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false What does this subpart require? 33.201 Section 33.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE PARTICIPATION BY DISADVANTAGED BUSINESS ENTERPRISES IN UNITED STATES ENVIRONMENTAL...

  16. CERCLA reporting requirements, DOE occurrence reporting, and the DOE Emergency Management System. CERCLA Information Brief

    SciTech Connect

    Dailey, R.

    1993-10-01

    The Emergency Management System (EMS) provides a structure for reporting and processing operations information related to DOE owned/operated facilities. Hazardous Substance (HS) releases are subject to reporting requirements under the EMS as well as under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). CERCLA requires reporting of HS releases into the environment in amounts greater than or equal to Reportable Quantities (RQs). This Information Brief elaborates on earlier CERCLA reporting and response process information Briefs by providing a general explanation of these CERCLA or EMS requirements, procedures, and events as they pertain to releases of HS`s at DOE facilities.

  17. Status Update for Implementing Best Available Technology per DOE Order 5400.5

    SciTech Connect

    Lewis, Michael George

    2001-09-01

    This report documents the Bechtel BWXT Idaho, LCC, operated facilities at the Idaho National Engineering and Environmental Laboratory that require the Best Available Technology selection process in accordance with Department of Energy Order 5400.5, Chapter II (3), “Management and Control of Radioactive Materials in Liquid Discharges.”1 This report differs from previous reports in that only those liquid waste streams and facilities requiring the Best Available Technology selection process will be evaluated in detail. In addition, this report will be submitted to the DOE-ID Field Office Manager for approval in accordance with DOE Order 5400.5, Chapter II, Section 3.b.(1). The report also identifies facilities addressed in last year’s report that do not require the Best Available Technology selection process to be completed. These facilities will not be addressed in future reports. This report reviews the following facilities: • Auxiliary Reactor Area • Idaho National Engineering and Environmental Laboratory Block Areas • Central Facilities Area • Idaho Nuclear Technology and Engineering Center • Idaho Falls Facilities • Power Burst Facility • Radioactive Waste Management Complex • Test Area North • Test Reactor Area. Three facilities (Central Facilities Area Sewage Treatment Plant, Idaho Nuclear Technology and Engineering Center Percolation Ponds and Test Area North/Technical Support Facility Disposal Pond) at the Idaho National Engineering and Environmental Laboratory required documentation of the Best Available Technology selection process. The Idaho Nuclear Technology and Engineering Center Percolation Ponds and Test Area North/Technical Support Facility Disposal Pond discharge wastewater that may contain process-derived radionuclides to a soil column with average radionuclide concentrations below drinking water MCLs. At the request of the Department of Energy Idaho Operations Office, Bechtel BWXT Idaho, LLC has included the 73.5acre

  18. 41 CFR 102-118.40 - How does my agency order transportation and transportation services?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false How does my agency order... Services § 102-118.40 How does my agency order transportation and transportation services? Your agency...., packaging, storage) with a Government contractor-issued charge card, purchase order (or...

  19. Report on inspection of compliance with DOE Order 2030.4B at the Savannah River Site

    SciTech Connect

    1997-03-01

    The purpose of this inspection was to evaluate contractor compliance at the Savannah River Site (SRS) with Department of Energy (DOE) Order 2030.4B, {open_quotes}Reporting Fraud, Waste, And Abuse To The Office Of Inspector General.{close_quotes} The specific objective was to determine if the SRS management and operating (M&O) contractors were complying with the requirements in Paragraph 6.c. of DOE Order 2030.4B. These requirements are: (1) annual notification to employees of their duty to report allegations of fraud, waste, abuse, corruption, or mismanagement; (2) display and publish the DOE Office of Inspector General (OIG) Hotline telephone number in common areas of buildings; (3) display and publish the DOE OIG Hotline number in telephone books and newsletters; and (4) notify the OIG cases referred to other law enforcement entities.

  20. Status Update for Implementing Best Available Technology per DOE Order 5400.5 (2003)

    SciTech Connect

    Michael Lewis

    2004-09-01

    This report identifies discharges of liquid waste streams that require documentation of the best available technology selection process at Bechtel BWXT Idaho, LLC, operated facilities at the Idaho National Engineering and Environmental Laboratory. The best available technology selection process is conducted according to Department of Energy Order 5400.5, Chapter II (3), “Management and Control of Radioactive Materials in Liquid Discharges and Phaseout of Soil Columns” and Department of Energy guidance. This report evaluates only those liquid waste streams and facilities where the best available technology selection process was determined to apply. Two facilities (Idaho Nuclear Technology and Engineering Center New Percolation Ponds and Test Area North/Technical Support Facility Sewage Treatment Plant Disposal Pond) at the Idaho National Engineering and Environmental Laboratory required documentation of the best available technology selection process. These two facilities required documentation of the best available technology selection process because they discharge wastewater that may contain process-derived radionuclides to a soil column even though the average radioactivity levels are typically below drinking water maximum contaminant levels. At the request of the Department of Energy Idaho Operations Office, the 73.5-acre Central Facilities Area Sewage Treatment Plant land application site is included in this report to ensure the requirements of DOE Order 5400.5, Chapter II, Section 3 are met. The Central Facilities Area Sewage Treatment Plant effluent contains process-derived radionuclides from radioactive tracers used in certain analytical procedures. The radioactivity levels of these radionuclides are below maximum contaminant levels. The Department of Energy Idaho Operations Office will submit this report to their field office manager for approval according to DOE Order 5400.5, Chapter II, Section 3.b.(1).

  1. Role sequencing: does order matter for mental health?

    PubMed

    Jackson, Pamela Braboy

    2004-06-01

    Role sequencing refers to the ordering of social roles. According to the normative order hypothesis, adults who follow a certain sequencing of their social roles will be better adjusted than their peers who follow other life course patterns. The normative order is defined as first entering the paid labor force, getting married, and later having children. This study tests this hypothesis by analyzing retrospective life history data from three subsamples of adults who completed the 1987--1988 National Survey of Families and Households: (1) married, working parents; (2) divorced, working parents; and (3) married, unemployed parents. The findings indicate significant race/ethnic (black/white), gender, and cohort differences in the type of role sequencing patterns that are conducive to positive mental health. For example, African Americans who work first, then have children, and later get married report better mental health than their peers who followed the normative order White men and women seem to benefit from following the normative course of role transitions. Among women, however, the psychological benefits of following typical life course patterns are especially evident among those born during the baby boom. PMID:15305756

  2. Parent-Child Quality Time: Does Birth Order Matter?

    ERIC Educational Resources Information Center

    Price, Joseph

    2008-01-01

    Using data from the American Time Use Survey, I find that a first-born child receives 20-30 more minutes of quality time each day with his or her parent than a second-born child of the same age from a similar family. The birth-order difference results from parents giving roughly equal time to each child at any point in time while the amount of…

  3. 20 CFR 1002.290 - Does VETS have the authority to order compliance with USERRA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Does VETS have the authority to order... and Referral § 1002.290 Does VETS have the authority to order compliance with USERRA? No. If VETS determines as a result of an investigation that the complaint is meritorious, VETS attempts to resolve...

  4. IDENTIFICATION OF DOE'S POST-CLOSURE MONITORING NEEDS AND REQUIREMENTS

    SciTech Connect

    M.A. Ebadian, Ph.D.

    1999-01-01

    The 2006 plan sets an ambitious agenda for the U.S. Department of Energy (DOE), Office of Environmental Management (EM) and the remediation of sites contaminated by decades of nuclear weapons production activities. The plan's primary objective is to reduce overall clean up costs by first eliminating the environmental problems that are most expensive to control and safely maintain. In the context of the 2006 Plan, closure refers to the completion of area or facility specific cleanup projects. The cleanup levels are determined by the planned future use of the site or facility. Use restrictions are still undecided for most sites but are highly probable to exclude residential or agricultural activities. Most of the land will be remediated to ''industrial use'' levels with access restrictions and some areas will be closed-off through containment. Portions of the site will be reserved for waste disposal, either as a waste repository or the in-situ immobilization of contaminated soil and groundwater, and land use will be restricted to waste disposal only. The land used for waste disposal will require monitoring and maintenance activities after closure. Most of the land used for industrial use may also require such postclosure activities. The required postclosure monitoring and maintenance activities will be imposed by regulators and stakeholders. Regulators will not approve closure plans without clearly defined monitoring methods using approved technologies. Therefore, among all other more costly and labor-intensive closure-related activities, inadequate planning for monitoring and lack of appropriate monitoring technologies can prevent closure. The purpose of this project is to determine, document, and track the current and evolving postclosure monitoring requirements at DOE-EM sites. This information will aid CMST-CP in guiding its postclosure technology development and deployment efforts.

  5. Status Update for Implementing Best Available Technology per DOE Order 5400.5 - September 2002

    SciTech Connect

    Lewis, Michael George

    2002-09-01

    This report identifies discharges of liquid waste streams that require documentation of the Best Available Technology selection process at Bechtel BWXT Idaho, LLC, operated facilities at the Idaho National Engineering and Environmental Laboratory. The Best Available Technology selection process is conducted according to Department of Energy Order 5400.5, Chapter II (3),“Management and Control of Radioactive Materials in Liquid Discharges and Phaseout of Soil Columns” and Department of Energy guidance. Only those liquid waste streams and facilities requiring the Best Available Technology selection process are evaluated in further detail. In addition, this report will be submitted to the Department of Energy Idaho Operations Office Field Office manager for approval according to DOE Order 5400.5, Chapter II, Section 3.b.(1). Two facilities (Idaho Nuclear Technology and Engineering Center existing Percolation Ponds and Test Area North/Technical Support Facility Disposal Pond) at the Idaho National Engineering and Environmental Laboratory required documentation of the Best Available Technology selection process (Section 4). These two facilities required documentation of the Best Available Technology selection process because they discharge wastewater that may contain process-derived radionuclides to a soil column even though the average radioactivity levels are typically below drinking water maximum contaminant levels. At the request of the Department of Energy Idaho Operations Office, the 73.5-acre Central Facilities Area Sewage Treatment Plant land application site is included in Section 4 of this report to ensure the requirements of DOE Order 5400.5, Chapter II, Section 3 are met. The Central Facilities Area Sewage Treatment Plant effluent contains process-derived radionuclides from radioactive tracers used in certain analytical procedures. The radioactivity levels of these radionuclides are below maximum contaminant levels. According to Department of Energy

  6. Status Update for Implementing Best Available Technology per DOE Order 5400.5

    SciTech Connect

    Michael G. Lewis

    2003-09-01

    This report identifies discharges of liquid waste streams that require documentation of the best available technology selection process at Bechtel BWXT Idaho, LLC, operated facilities at the Idaho National Engineering and Environmental Laboratory. The best available technology selection process is conducted according to Department of Energy Order 5400.5, Chapter II (3), ''Management and Control of Radioactive Materials in Liquid Discharges and Phaseout of Soil Columns'' and Department of Energy guidance. This report evaluates only those liquid waste streams and facilities where the best available technology selection process was determined to be applicable. In addition, the Department of Energy Idaho Operations Office will submit this report to their field office manager for approval according to DOE Order 5400.5, Chapter II, Section 3.b.(1). According to Department of Energy guidance, ''If the liquid waste stream is below maximum contaminant levels, then the goals of the best available technology selection process are being met and the liquid waste stream is considered 'clean water.' However, it is necessary to document this through the best available technology selection process.'' Because liquid waste streams below drinking water maximum contaminant levels are already considered ''clean water,'' additional treatment technologies are considered unnecessary and unjustifiable on a cost-benefit basis and are not addressed in this report. Two facilities (Idaho Nuclear Technology and Engineering Center New Percolation Ponds and Test Area North/Technical Support Facility Disposal Pond) at the Idaho National Engineering and Environmental Laboratory required documentation of the best available technology selection process (Section 4). These two facilities required documentation of the best available technology selection process because they discharge wastewater that may contain process-derived radionuclides to a soil column even though the average radioactivity levels

  7. Task Effects on Tactile Temporal Order Judgments: When Space Does and Does Not Matter

    ERIC Educational Resources Information Center

    Roberts, Roberta D.; Humphreys, Glyn W.

    2008-01-01

    The ability to report the temporal order of 2 tactile stimuli (1 applied to each hand) has been shown to decline when the arms are crossed over compared with when they are uncrossed. However, these effects have only been measured when temporal order was reported by stimulus location. It is unknown whether this spatial manipulation of the body…

  8. Comparison of selected DOE and non-DOE requirements, standards, and practices for Low-Level Radioactive Waste Disposal

    SciTech Connect

    Cole, L.; Kudera, D.; Newberry, W.

    1995-12-01

    This document results from the Secretary of Energy`s response to Defense Nuclear Facilities Safety Board Recommendation 94--2. The Secretary stated that the US Department of Energy (DOE) would ``address such issues as...the need for additional requirements, standards, and guidance on low-level radioactive waste management. `` The authors gathered information and compared DOE requirements and standards for the safety aspects Of low-level disposal with similar requirements and standards of non-DOE entities.

  9. Canister storage building compliance assessment DOE Order 6430.1A, General Design Criteria

    SciTech Connect

    BLACK, D.M.

    1999-08-12

    This document presents the Project's position on compliance with DOE Order 6430.1A ''General Design Criteria.'' No non-compliances are shown. The compliance statements have been reviewed and approved by DOE. Open items are scheduled to be closed prior to project completion.

  10. Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability

    PubMed Central

    Kořený, Luděk; Sobotka, Roman; Kovářová, Julie; Gnipová, Anna; Flegontov, Pavel; Horváth, Anton; Oborník, Miroslav; Ayala, Francisco J.; Lukeš, Julius

    2012-01-01

    Heme is an iron-coordinated porphyrin that is universally essential as a protein cofactor for fundamental cellular processes, such as electron transport in the respiratory chain, oxidative stress response, or redox reactions in various metabolic pathways. Parasitic kinetoplastid flagellates represent a rare example of organisms that depend on oxidative metabolism but are heme auxotrophs. Here, we show that heme is fully dispensable for the survival of Phytomonas serpens, a plant parasite. Seeking to understand the metabolism of this heme-free eukaryote, we searched for heme-containing proteins in its de novo sequenced genome and examined several cellular processes for which heme has so far been considered indispensable. We found that P. serpens lacks most of the known hemoproteins and does not require heme for electron transport in the respiratory chain, protection against oxidative stress, or desaturation of fatty acids. Although heme is still required for the synthesis of ergosterol, its precursor, lanosterol, is instead incorporated into the membranes of P. serpens grown in the absence of heme. In conclusion, P. serpens is a flagellate with unique metabolic adaptations that allow it to bypass all requirements for heme. PMID:22355128

  11. Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability.

    PubMed

    Kořený, Luděk; Sobotka, Roman; Kovářová, Julie; Gnipová, Anna; Flegontov, Pavel; Horváth, Anton; Oborník, Miroslav; Ayala, Francisco J; Lukeš, Julius

    2012-03-01

    Heme is an iron-coordinated porphyrin that is universally essential as a protein cofactor for fundamental cellular processes, such as electron transport in the respiratory chain, oxidative stress response, or redox reactions in various metabolic pathways. Parasitic kinetoplastid flagellates represent a rare example of organisms that depend on oxidative metabolism but are heme auxotrophs. Here, we show that heme is fully dispensable for the survival of Phytomonas serpens, a plant parasite. Seeking to understand the metabolism of this heme-free eukaryote, we searched for heme-containing proteins in its de novo sequenced genome and examined several cellular processes for which heme has so far been considered indispensable. We found that P. serpens lacks most of the known hemoproteins and does not require heme for electron transport in the respiratory chain, protection against oxidative stress, or desaturation of fatty acids. Although heme is still required for the synthesis of ergosterol, its precursor, lanosterol, is instead incorporated into the membranes of P. serpens grown in the absence of heme. In conclusion, P. serpens is a flagellate with unique metabolic adaptations that allow it to bypass all requirements for heme. PMID:22355128

  12. Transitive Responding in Hooded Crows Requires Linearly Ordered Stimuli

    ERIC Educational Resources Information Center

    Lazareva, Olga F.; Smirnova, Anna A.; Bagozkaja, Maria S.; Zorina, Zoya A.; Rayevsky, Vladimir V.; Wasserman, Edward A.

    2004-01-01

    Eight crows were taught to discriminate overlapping pairs of visual stimuli (A+ B-, B+ C-, C+ D-, and D+ E-). For 4 birds, the stimuli were colored cards with a circle of the same color on the reverse side whose diameter decreased from A to E (ordered feedback group). These circles were made available for comparison to potentially help the crows…

  13. 41 CFR 102-118.40 - How does my agency order transportation and transportation services?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How does my agency order transportation and transportation services? 102-118.40 Section 102-118.40 Public Contracts and Property... TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Ordering and Paying for Transportation and...

  14. Does massive intraabdominal free gas require surgical intervention?

    PubMed Central

    Furihata, Tadashi; Furihata, Makoto; Ishikawa, Kunibumi; Kosaka, Masato; Satoh, Naoki; Kubota, Keiichi

    2016-01-01

    We describe a rare case of an 81-year-old man who presented with severe epigastralgia. A chest radiograph showed massive free gas bilaterally in the diaphragmatic spaces. Computed tomography (CT) scan also showed massive free gas in the peritoneal cavity with portal venous gas. We used a wait-and-see approach and carefully considered surgery again when the time was appropriate. The patient received conservative therapy with fasting, an intravenous infusion of antibiotics, and nasogastric intubation. The patient soon recovered and was able to start eating meals 4 d after treatment; thus, surgical intervention was avoided. Thereafter, colonoscopy examination showed pneumatosis cystoides intestinalis in the ascending colon. On retrospective review, CT scan demonstrated sporadic air-filled cysts in the ascending colon. The present case taught us a lesson: the presence of massive intraabdominal free gas with portal venous gas does not necessarily require surgical intervention. Pneumatosis cystoides intestinalis should be considered as a potential causative factor of free gas with portal venous gas when making the differential diagnosis. PMID:27621584

  15. Does massive intraabdominal free gas require surgical intervention?

    PubMed

    Furihata, Tadashi; Furihata, Makoto; Ishikawa, Kunibumi; Kosaka, Masato; Satoh, Naoki; Kubota, Keiichi

    2016-08-28

    We describe a rare case of an 81-year-old man who presented with severe epigastralgia. A chest radiograph showed massive free gas bilaterally in the diaphragmatic spaces. Computed tomography (CT) scan also showed massive free gas in the peritoneal cavity with portal venous gas. We used a wait-and-see approach and carefully considered surgery again when the time was appropriate. The patient received conservative therapy with fasting, an intravenous infusion of antibiotics, and nasogastric intubation. The patient soon recovered and was able to start eating meals 4 d after treatment; thus, surgical intervention was avoided. Thereafter, colonoscopy examination showed pneumatosis cystoides intestinalis in the ascending colon. On retrospective review, CT scan demonstrated sporadic air-filled cysts in the ascending colon. The present case taught us a lesson: the presence of massive intraabdominal free gas with portal venous gas does not necessarily require surgical intervention. Pneumatosis cystoides intestinalis should be considered as a potential causative factor of free gas with portal venous gas when making the differential diagnosis. PMID:27621584

  16. Implementation of the Methamphetamine Anti-Proliferation Act; thresholds for retailers and for distributors required to submit mail order reports; changes to mail order reporting requirements. Final rule.

    PubMed

    2003-10-01

    This regulation implements the new threshold requirements and mail order reporting requirements of the Methamphetamine Anti-Proliferation Act of 2000 (MAPA), which was enacted on October 17, 2000. DEA is amending its regulations to reduce the thresholds for pseudoephedrine and phenylpropanolamine for retail distributors and for distributors required to submit mail order reports. Also, DEA is amending its regulations to require mail order reports for certain export transactions. DEA is codifying exemptions from the mail order reporting requirements for certain distributions to nonregulated persons and certain export transactions. This rule is consistent with the intent of MAPA to prevent the diversion of drug products to the clandestine manufacture of methamphetamine and amphetamine, and simultaneously reduce the industry reporting burden. PMID:14535265

  17. Idaho CERCLA Disposal Facility Complex Compliance Demonstration for DOE Order 435.1

    SciTech Connect

    Simonds, J.

    2007-11-06

    This compliance demonstration document provides an analysis of the Idaho CERCLA Disposal Facility (ICDF) Complex compliance with DOE Order 435.1. The ICDF Complex includes the disposal facility (landfill), evaporation pond, administration facility, weigh scale, and various staging/storage areas. These facilities were designed and constructed to be compliant with DOE Order 435.1, Resource Conservation and Recovery act Subtitle C, and Toxic Substances Control Act polychlorinated biphenyl design and construction standards. The ICDF Complex is designated as the Idaho National Laboratory (INL) facility for the receipt, staging/storage, treatment, and disposal of INL Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) waste streams.

  18. Evaluation of the Cask Transportation Facility Modifications (CTFM) compliance to DOE order 6430.1A Project A.5 and A.6

    SciTech Connect

    ARD, K.E.

    2000-04-24

    This report was prepared to evaluate the compliance of CTFM to DOE Order 6430.1A. This document presents the results of an evaluation that was performed to assess compliance of the K West (KW) Cask Transportation Facility Modifications (CTFM) designs against applicable requirements of Department of Energy (DOE) Order 6430.1 A, General Design Criteria. This evaluation was grouped under two categories described as Cask Loadout System (CLS) and Cranes/Other Modifications.

  19. Hazardous Substance Release Reporting Under CERCLA, EPCR {section}304 and DOE Emergency Management System (EMS) and DOE Occurrence Reporting Requirements. Environmental Guidance

    SciTech Connect

    Traceski, T.T.

    1994-06-01

    Releases of various substances from DOE facilities may be subject to reporting requirements under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the Emergency Planning and Community Right-to-Know Act (EPCRA), as well as DOE`s internal ``Occurrence Reporting and Processing of Operations Information`` and the ``Emergency Management System`` (EMS). CERCLA and EPCPA are Federal laws that require immediate reporting of a release of a Hazardous Substance (HS) and an Extremely Hazardous Substance (EHS), respectively, in a Reportable Quantity (RQ) or more within a 24-hour period. This guidance uses a flowchart, supplemental information, and tables to provide an overview of the process to be followed, and more detailed explanations of the actions that must be performed, when chemical releases of HSs, EHSs, pollutants, or contaminants occur at DOE facilities. This guidance should be used in conjunction with, rather than in lieu of, applicable laws, regulations, and DOE Orders. Relevant laws, regulations, and DOE Orders are referenced throughout this guidance.

  20. 21 CFR 1.378 - What criteria does FDA use to order a detention?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false What criteria does FDA use to order a detention? 1.378 Section 1.378 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ENFORCEMENT REGULATIONS Administrative Detention of Food for Human or Animal...

  1. 21 CFR 1.384 - When does a detention order terminate?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false When does a detention order terminate? 1.384 Section 1.384 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ENFORCEMENT REGULATIONS Administrative Detention of Food for Human or Animal Consumption...

  2. 30 CFR 585.420 - What effect does a suspension order have on my payments?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What effect does a suspension order have on my payments? 585.420 Section 585.420 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Lease and Grant Administration...

  3. 41 CFR 102-118.40 - How does my agency order transportation and transportation services?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false How does my agency order transportation and transportation services? 102-118.40 Section 102-118.40 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT...

  4. 41 CFR 102-118.40 - How does my agency order transportation and transportation services?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false How does my agency order transportation and transportation services? 102-118.40 Section 102-118.40 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT...

  5. Does the Sharpness of the Gutenberg Discontinuity Require Melt?

    NASA Astrophysics Data System (ADS)

    Bagley, B.; Revenaugh, J.

    2008-12-01

    A low-velocity zone (LVZ) underlying the fast seismic lid has been recognized since Gutenberg (1959). While, strictly speaking, the asthenosphere and the LVZ are defined by different properties, their upper boundaries are functionally equivalent in the oceanic setting. The Gutenberg (G) discontinuity marks the seismically sharp upper boundary of the lid-low-velocity transition beneath oceans and is characterized by an abrupt shear wave impedance decrease of roughly 9%. Explanations for the low seismic velocities include a contrast in volatile content, structurally bound water, and the effects of temperature and grain size. Partial melt, which once enjoyed the status of an obvious cause, has fallen from favor, primarily because of the difficulty of retaining a connecting fluid phase in the LVZ. But recent results demonstrate large velocity decrements for very small grain boundary melt fractions that could remain unconnected and trapped in the LVZ (Faul and Jackson, 2007). In order to provide better constraints on the structure of the low-velocity zone, we have examined the G discontinuity beneath a large portion of the central and western Pacific. Our focus is on the sharpness of the G reflector and the impedance decrease across it. Using multiple ScS reverberations we sampled the G discontinuity along a series of oceanic paths. We obtain impedance decreases between 4.7 and 14.2%, averaging 9.1%, assuming a first-order discontinuity. Our data do not, however, require the change in impedance to be sharp and can easily tolerate an extended transition of 10 to 15 km with little change in the estimated impedance contrast. However, extending the transition further requires a greater net impedance decrease across the interval. This provides an important constraint on the thickness of the transition interval. Preliminary results that consider acceptable net impedance contrasts (obtained from surface wave and turning wave constraints on LVZ severity) impose a conservative

  6. 21 CFR 1311.55 - Requirements for systems used to process digitally signed orders.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Requirements for systems used to process digitally signed orders. 1311.55 Section 1311.55 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS Obtaining and Using Digital Certificates for Electronic Orders § 1311.55...

  7. Proposed Risk-Informed Seismic Hazard Periodic Reevaluation Methodology for Complying with DOE Order 420.1C

    SciTech Connect

    Kammerer, Annie

    2015-10-01

    Department of Energy (DOE) nuclear facilities must comply with DOE Order 420.1C Facility Safety, which requires that all such facilities review their natural phenomena hazards (NPH) assessments no less frequently than every ten years. The Order points the reader to Standard DOE-STD-1020-2012. In addition to providing a discussion of the applicable evaluation criteria, the Standard references other documents, including ANSI/ANS-2.29-2008 and NUREG-2117. These documents provide supporting criteria and approaches for evaluating the need to update an existing probabilistic seismic hazard analysis (PSHA). All of the documents are consistent at a high level regarding the general conceptual criteria that should be considered. However, none of the documents provides step-by-step detailed guidance on the required or recommended approach for evaluating the significance of new information and determining whether or not an existing PSHA should be updated. Further, all of the conceptual approaches and criteria given in these documents deal with changes that may have occurred in the knowledge base that might impact the inputs to the PSHA, the calculated hazard itself, or the technical basis for the hazard inputs. Given that the DOE Order is aimed at achieving and assuring the safety of nuclear facilities—which is a function not only of the level of the seismic hazard but also the capacity of the facility to withstand vibratory ground motions—the inclusion of risk information in the evaluation process would appear to be both prudent and in line with the objectives of the Order. The purpose of this white paper is to describe a risk-informed methodology for evaluating the need for an update of an existing PSHA consistent with the DOE Order. While the development of the proposed methodology was undertaken as a result of assessments for specific SDC-3 facilities at Idaho National Laboratory (INL), and it is expected that the application at INL will provide a demonstration of the

  8. 41 CFR 102-192.95 - Why does GSA require annual mail management reports?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Why does GSA require annual mail management reports? 102-192.95 Section 102-192.95 Public Contracts and Property Management... PROGRAMS 192-MAIL MANAGEMENT Reporting Requirements § 102-192.95 Why does GSA require annual...

  9. 41 CFR 102-192.95 - Why does GSA require annual mail management reports?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Why does GSA require annual mail management reports? 102-192.95 Section 102-192.95 Public Contracts and Property Management... PROGRAMS 192-MAIL MANAGEMENT Reporting Requirements § 102-192.95 Why does GSA require annual...

  10. 21 CFR 1311.50 - Requirements for recipients of digitally signed orders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS Obtaining and Using Digital Certificates for Electronic... digital certificate has not expired by checking the expiration date against the date the order was...

  11. 21 CFR 1311.50 - Requirements for recipients of digitally signed orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS (Eff. 6-1-10) Obtaining and Using Digital Certificates for... signature and the order by having the system validate the order. (2) Verify that the certificate holder's CSOS digital certificate has not expired by checking the expiration date against the date the order...

  12. Enforcement handbook: Enforcement of DOE nuclear safety requirements

    SciTech Connect

    1995-06-01

    This Handbook provides detailed guidance and procedures to implement the General Statement of DOE Enforcement Policy (Enforcement Policy or Policy). A copy of this Enforcement Policy is included for ready reference in Appendix D. The guidance provided in this Handbook is qualified, however, by the admonishment to exercise discretion in determining the proper disposition of each potential enforcement action. As discussed in subsequent chapters, the Enforcement and Investigation Staff will apply a number of factors in assessing each potential enforcement situation. Enforcement sanctions are imposed in accordance with the Enforcement Policy for the purpose of promoting public and worker health and safety in the performance of activities at DOE facilities by DOE contractors (and their subcontractors and suppliers) who are indemnified under the Price-Anderson Amendments Act. These indemnified contractors, and their suppliers and subcontractors, will be referred to in this Handbook collectively as DOE contractors. It should be remembered that the purpose of the Department`s enforcement policy is to improve nuclear safety for the workers and the public, and this goal should be the prime consideration in exercising enforcement discretion.

  13. References for HNF-SD-WM-TRD-007, ``System specification for the double-shell tank system: HNF-PROs, CFRs, DOE Orders, WACs``

    SciTech Connect

    Shaw, C.P.

    1998-07-30

    HNF-SD-WM-TRD-O07, System Specification for the Double-Shell Tank System, (hereafter referred to as DST Specification), defines the requirements of the double-shell tank system at the Hanford Site for Phase 1 privatization. Many of the sections in this document reference other documents for design guidance and requirements. Referenced documents include Project Hanford Management Contract (PHMC) procedures (HNF-PROS), Codes of Federal Regulation (CFRs), DOE Orders, and Washington Administrative Codes (WACs). This document provides rationale for the selection and inclusion of HNF-PROS, CFRs, DOE Orders and WACs.

  14. A conceptual framework for using DOE 5700.6C and the other DOE orders as an integrated management system; the Fermilab experience

    SciTech Connect

    Bodnarczuk, M.

    1992-06-01

    In this paper, I describe a conceptual framework that uses DOE Order 5700.6C and more than 140 other DOE Orders as an integrated management system -- but I describe it within the context of the broader sociological and cultural issues of doing research at DOE funded facilities. The conceptual framework has two components. The first involves an interpretation of the 10 criteria of DOE 5700.6C that is tailored for a research environment. The second component involves using the 10 criteria as functional categories that orchestrate and integrate the other DOE Orders into a total management system. The Fermilab approach aims at reducing (or eliminating) the redundancy and overlap within the DOE Orders system at the contractor level.

  15. A conceptual framework for using DOE 5700. 6C and the other DOE orders as an integrated management system; the Fermilab experience

    SciTech Connect

    Bodnarczuk, M.

    1992-06-01

    In this paper, I describe a conceptual framework that uses DOE Order 5700.6C and more than 140 other DOE Orders as an integrated management system -- but I describe it within the context of the broader sociological and cultural issues of doing research at DOE funded facilities. The conceptual framework has two components. The first involves an interpretation of the 10 criteria of DOE 5700.6C that is tailored for a research environment. The second component involves using the 10 criteria as functional categories that orchestrate and integrate the other DOE Orders into a total management system. The Fermilab approach aims at reducing (or eliminating) the redundancy and overlap within the DOE Orders system at the contractor level.

  16. 43 CFR 3216.14 - What filing fees and forms does a transfer require?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What filing fees and forms does a transfer require? 3216.14 Section 3216.14 Public Lands: Interior Regulations Relating to Public Lands (Continued... LEASING Transfers § 3216.14 What filing fees and forms does a transfer require? With each transfer...

  17. 43 CFR 3216.14 - What filing fees and forms does a transfer require?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What filing fees and forms does a transfer require? 3216.14 Section 3216.14 Public Lands: Interior Regulations Relating to Public Lands (Continued... LEASING Transfers § 3216.14 What filing fees and forms does a transfer require? With each transfer...

  18. 43 CFR 3216.14 - What filing fees and forms does a transfer require?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What filing fees and forms does a transfer require? 3216.14 Section 3216.14 Public Lands: Interior Regulations Relating to Public Lands (Continued... LEASING Transfers § 3216.14 What filing fees and forms does a transfer require? With each transfer...

  19. 43 CFR 3216.14 - What filing fees and forms does a transfer require?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false What filing fees and forms does a transfer require? 3216.14 Section 3216.14 Public Lands: Interior Regulations Relating to Public Lands (Continued... LEASING Transfers § 3216.14 What filing fees and forms does a transfer require? With each transfer...

  20. 13 CFR 123.11 - Does SBA require collateral for any of its disaster loans?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Does SBA require collateral for any of its disaster loans? 123.11 Section 123.11 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Overview § 123.11 Does SBA require collateral for any of its disaster...

  1. 24 CFR 1000.143 - How does a recipient implement its useful life requirements?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false How does a recipient implement its useful life requirements? 1000.143 Section 1000.143 Housing and Urban Development REGULATIONS RELATING TO... § 1000.143 How does a recipient implement its useful life requirements? A recipient implements its...

  2. 13 CFR 123.11 - Does SBA require collateral for any of its disaster loans?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Does SBA require collateral for any of its disaster loans? 123.11 Section 123.11 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Overview § 123.11 Does SBA require collateral for any of its disaster...

  3. 13 CFR 123.11 - Does SBA require collateral for any of its disaster loans?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Does SBA require collateral for any of its disaster loans? 123.11 Section 123.11 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Overview § 123.11 Does SBA require collateral for any of its disaster...

  4. 48 CFR 908.1102 - Presolicitation requirements. (DOE coverage-paragraph (a))

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... requirements. (DOE coverage-paragraph (a)) 908.1102 Section 908.1102 Federal Acquisition Regulations System... Motor Vehicles 908.1102 Presolicitation requirements. (DOE coverage—paragraph (a)) (a)(4) Commercial vehicle lease sources may be used only when the General Services Administration (GSA) has advised that...

  5. 25 CFR 42.6 - When does due process require a formal disciplinary hearing?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false When does due process require a formal disciplinary hearing? 42.6 Section 42.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION STUDENT RIGHTS § 42.6 When does due process require a formal disciplinary hearing? Unless local school...

  6. 48 CFR 1211.101 - Order of precedence for requirements documents.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Order of precedence for requirements documents. 1211.101 Section 1211.101 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Selecting and Developing Requirements Documents 1211.101 Order of precedence...

  7. 18 CFR 35.19a - Refund requirements under suspension orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... under suspension orders. 35.19a Section 35.19a Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT FILING OF RATE SCHEDULES AND TARIFFS Other Filing Requirements § 35.19a Refund requirements under suspension orders....

  8. MARSSIM vs. DOE Order 5400.5: the Final Status Survey plan at the Rocky Flats Environmental Technology Site.

    PubMed

    Roberts, Sarah J; Stevens, Jeff

    2003-06-01

    A challenge unique to the decommissioning of Department of Energy (DOE) facilities involves the compromise between the existing and newly recommended standards for the unrestricted release of property and materials. The Rocky Flats Environmental Technology Site (RFETS) is currently decommissioning numerous plutonium contaminated facilities. The default DOE standard for unrestricted release, Order 5400.5, defines surface activity guidelines as averaged over a 1-square-meter area with a maximum value defined for any given 100-square-centimeter area. While the Order was initially developed to release property and materials from an operating site, it is restrictive in its use when performing Final Status Survey and, to date, no new complex wide standard has been developed. However, the RFETS stakeholders selected the MARSSIM, which provides a progressive method to demonstrate compliance with the defined "dose-based" limits for a specific site, as the governing document in developing a final survey method. The end result is a hybrid final status survey plan that incorporates the requirements of both documents. This plan represents several years of development and negotiation between the contractor, the DOE, the Colorado Department of Public Health and Environment, the Rocky Flats stakeholders, and other interested parties. PMID:12792399

  9. Geographers as Planners: What Skills Does the Job Require.

    ERIC Educational Resources Information Center

    Stephens, David T.

    A survey of 524 planning agencies and consultants in the Midwest and Southwest was undertaken in 1976 to identify skills required for planning and to assess current capabilities in those skill areas. The major purpose of the survey was to aid geographic educators as they prepare students for careers in the planning profession. One part of the…

  10. 40 CFR 33.301 - What does this subpart require?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... too large for one of these firms to handle individually. (e) Use the services and assistance of the SBA and the Minority Business Development Agency of the Department of Commerce. (f) If the prime contractor awards subcontracts, require the prime contractor to take the steps in paragraphs (a) through...

  11. 40 CFR 33.301 - What does this subpart require?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... too large for one of these firms to handle individually. (e) Use the services and assistance of the SBA and the Minority Business Development Agency of the Department of Commerce. (f) If the prime contractor awards subcontracts, require the prime contractor to take the steps in paragraphs (a) through...

  12. The DOE Meteorological Coordinating Council Perspective on the Application to Meteorological Software of DOE's Software Quality Assurance Requirements

    SciTech Connect

    Mazzola, Carl; Schalk, Walt; Glantz, Clifford S.

    2008-03-12

    Since 1994, the DOE Meteorological Coordinating Council (DMCC) has been addressing meteorological monitoring and meteorological applications program issues at U.S. Department of Energy/National Nuclear Safety Administration (DOE/NNSA) sites and providing solutions to these issues. The fundamental objectives of the DMCC include promoting cost-effective meteorological support and facilitating the use of common meteorological methods, procedures, and standards at all DOE/NNSA sites. In 2005, the DOE established strict software quality assurance (SQA) requirements for safety software, including consequence assessment software used for hazard assessments and safety analyses. These evaluations often utilize meteorological data supplied by DOE/NNSA site-based meteorological programs. However, the DOE has not established SQA guidance for this type of safety-related meteorological software. To address this gap, the DMCC is developing this guidance for the use of both public- and private-sector organizations. The goal for the DMCC is to mimic the SQA requirements for safety software but allow a much greater degree of “grading” in determining exactly what specific activities are needed. The emphasis of the DMCC SQA guidelines is on three key elements: 1) design and implementation documentation, 2) configuration management, and 3) verification and validation testing. These SQA guidelines should provide owners and users of meteorological software with a fair degree of assurance that their software is reliable, documented, and tested without putting an undue burden on meteorological system software developers.

  13. The Timing of Acupuncture Stimulation Does Not Influence Anesthetic Requirement

    PubMed Central

    Chernyak, Grigory; Sengupta, Papiya; Lenhardt, Rainer; Liem, Edwin; Doufas, Anthony G.; Sessler, Daniel I.; Akça, Ozan

    2005-01-01

    Studies suggest that acupuncture is more effective when induced before induction of general anesthesia than afterwards. We tested the hypothesis that electro-acupuncture initiated 30 minutes before induction reduces anesthetic requirement more than acupuncture initiated after induction. Seven volunteers were each anesthetized with desflurane on 3 study days. Needles were inserted percutaneously at 4 acupuncture points thought to produce analgesia in the upper abdominal area and provide generalized sedative and analgesic effects: Zusanli (St36), Sanyinjiao (Sp6), Liangqiu (St34), and Hegu (LI4). Needles were stimulated at 2-Hz and 10-Hz, with frequencies alternating at two-second intervals. On Preinduction day, electro-acupuncture was started 30 minutes before induction of anesthesia and maintained throughout the study. On At-induction day, needles were positioned before induction of anesthesia, but electro-acupuncture stimulation was not initiated until after induction. On Control day, electrodes were positioned near the acupoints, but needles were not inserted. Noxious electrical stimulation was administered via 25-G needles on the upper abdomen (70 mA, 100 Hz, 10 seconds). Desflurane concentration was increased 0.5% when movement occurred and decreased 0.5% when it did not. These up-and-down sequences continued until volunteers crossed from movement to no-movement 4 times. The P50 of logistic regression identified desflurane requirement. Desflurane requirement was similar on the Control (5.2±0.6%, mean±SD), Preinduction (5.0±0.8%), and At-induction (4.7±0.3%, P=0.125) days. This type of acupuncture is thus unlikely to facilitate general anesthesia or decrease the need for anesthetic drugs. PMID:15673863

  14. Hawking-like radiation does not require a trapped region.

    PubMed

    Barceló, Carlos; Liberati, Stefano; Sonego, Sebastiano; Visser, Matt

    2006-10-27

    We discuss the issue of quasiparticle production by "analogue black holes" with particular attention paid to the possibility of reproducing Hawking radiation in a laboratory. By constructing simple geometric acoustic models, we obtain a somewhat unexpected result: We show that, in order to obtain a stationary and Planckian emission of quasiparticles, it is not necessary to create a trapped region in the acoustic spacetime (corresponding to a supersonic regime in the fluid flow). It is sufficient to set up a dynamically changing flow asymptotically approaching a sonic regime with sufficient rapidity in laboratory time. This result is generic to curved-space quantum field theory, the "analogue spacetimes" we consider providing a guide to physical intuition, and a possible route to laboratory experiments. PMID:17155458

  15. Status Update for Implementation of Best Available Technology per DOE Order 5400.5

    SciTech Connect

    C. A. Major

    1999-07-01

    This report provides an update, as of July 1999, on the implementation of best available technology to control or eliminate radionuclide discharges to soil columns at facilities at the Idaho National Engineering and Environmental Laboratory in accordance with DOE Order 5400.5, ''Radiation Protection of the Public and Environment.'' The best available technology to reduce or eliminate radionuclide discharges to soil columns currently implemented by the different facilities appears to be generally effective. Therefore, the different facilities should continue their current best available technology approaches, and also implement the specific recommendations listed in this report for their respective facility.

  16. Requirements for shipment of DOE radioactive mixed waste

    SciTech Connect

    Gablin, K.; No, Hyo; Herman, J.

    1993-08-01

    There are several sources of radioactive mixed waste (RMW) at Argonne National Laboratory which, in the past, were collected at waste tanks and/or sludge tanks. They were eventually pumped out by special pumps and processed in an evaporator located in the waste operations area in Building No. 306. Some of this radioactive mixed waste represents pure elementary mercury. These cleaning tanks must be manually cleaned up because the RMW material was too dense to pump with the equipment in use. The four tanks being discussed in this report are located in Building No. 306. They are the Acid Waste Tank, IMOX/FLOC Tanks, Evaporation Feed Tanks, and Waste Storage Tanks. All of these tanks are characterized and handled separately. This paper discusses the process and the requirements for characterization and the associated paperwork for Argonne Waste to be shipped to Westinghouse Hanford Company for storage.

  17. What does respect for the patient's autonomy require?

    PubMed

    Cheng, Kam-Yuen

    2013-11-01

    Personal autonomy presupposes the notion of rationality. What is not so clear is whether, and how, a compromise of rationality to various degrees will diminish a person's autonomy. In bioethical literature, three major types of threat to the rationality of a patient's medical decision are identified: insufficient information, irrational beliefs/desires, and influence of different framing effects. To overcome the first problem, it is suggested that patients be provided with information about their diseases and treatment choices according to the objective standard. I shall explain how this should be finessed. Regarding the negative impact of irrational beliefs/desires, some philosophers have argued that holding irrational beliefs can still be an expression of autonomy. I reject this argument because the degree of autonomy of a decision depends on the degree of rationality of the beliefs or desires on which the decision is based. Hence, to promote patient autonomy, we need to eliminate irrational beliefs by the provision of evidence and good arguments. Finally, I argue that the way to smooth out the framing effects is to present the same information in different perspectives: it is too often assumed that medical information can always be given in a complete and unadorned manner. This article concludes with a cautionary note that the protection of patient autonomy requires much more time and effort than the current practice usually allows. PMID:22486249

  18. 78 FR 40773 - Order Imposing Requirements for the Protection of Certain Safeguards Information (Effective...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR... COMMISSION Order Imposing Requirements for the Protection of Certain Safeguards Information (Effective... Information Described Herein I The Licensee, identified in Attachment 1 \\1\\ to this Order, holds a ]...

  19. Idaho CERCLA Disposal Facility Complex Compliance Demonstration for DOE Order 435.1

    SciTech Connect

    J. Simonds

    2006-09-01

    This compliance demonstration document provides an analysis of the Idaho CERCLA Disposal Facility (ICDF) Complex compliance with DOE Order 435.1. The ICDF Complex includes the disposal facility (landfill), evaporation pond, admin facility, weigh scale, decon building, treatment systems, and various staging/storage areas. These facilities were designed and are being constructed to be compliant with DOE Order 435.1, Resource Conservation and Recovery Act Subtitle C, and Toxic Substances Control Act polychlorinated biphenyl design and construction standards. The ICDF Complex is designated as the central Idaho National Laboratory (INL) facilityyy for the receipt, staging/storage, treatment, and disposal of INL Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) waste streams. This compliance demonstration document discusses the conceptual site model for the ICDF Complex area. Within this conceptual site model, the selection of the area for the ICDF Complex is discussed. Also, the subsurface stratigraphy in the ICDF Complex area is discussed along with the existing contamination beneath the ICDF Complex area. The designs for the various ICDF Complex facilities are also included in this compliance demonstration document. These design discussions are a summary of the design as presented in the Remedial Design/Construction Work Plans for the ICDF landfill and evaporation pond and the Staging, Storage, Sizing, and Treatment Facility. Each of the major facilities or systems is described including the design criteria.

  20. 13 CFR 109.440 - Requirements imposed under other laws and orders.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Requirements imposed under other laws and orders. 109.440 Section 109.440 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION INTERMEDIARY LENDING PILOT PROGRAM Requirements for ILP Intermediary Loans to Small Businesses §...

  1. 13 CFR 109.440 - Requirements imposed under other laws and orders.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Requirements imposed under other laws and orders. 109.440 Section 109.440 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION INTERMEDIARY LENDING PILOT PROGRAM Requirements for ILP Intermediary Loans to Small Businesses §...

  2. 13 CFR 109.440 - Requirements imposed under other laws and orders.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Requirements imposed under other laws and orders. 109.440 Section 109.440 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION INTERMEDIARY LENDING PILOT PROGRAM Requirements for ILP Intermediary Loans to Small Businesses §...

  3. DOE ORDER 435.1, IMPLEMENTATION AND COMPLIANCE DECLARATION AT THE SAVANNAH RIVER SITE AND ACROSS THE DOE COMPLEX IN CONTRAST TO CURRENT PUSHBACK EFFORTS FROM THE ''TOP-TO-BOTTOM'' REVIEW

    SciTech Connect

    GOLDSTON, WELFORD T.; SMITH, WINCHESTER IV

    2003-02-27

    DOE issued Order 435.1, ''Radioactive Waste Management,'' on July 9, 1999 for immediate implementation. The requirements for Low Level Mixed, Transuranic, and High Level Waste have been completely rewritten. The entire DOE complex has been struggling with how to implement these new requirements within the one year required timeframe. This paper will chronicle the implementation strategy and actual results of the work to carry out that strategy at the Savannah River Site. DOE-SR and the site contractors worked closely together to implement each of the new requirements across the SRS, crossing many barriers and providing innovative solutions to the many problems that surfaced throughout the year. The results are that SRS declared compliance with all of the requirements of the Order within the prescribed timeframe. The challenge included all waste types in SRS facilities and programs that handle LLW, MLLW, TRU, and HLW. This paper will describe the implementation details for development of Radioactive Waste Management Basis for each facility, Identification of Wastes with No Path to Disposal, Waste Incidental to Reprocessing Determinations, Low Level Waste 90-Day Staging and One Year Limits for Storage Programs, to name a few of the requirements that were addressed by the SRS 435.1 Implementation Team. This paper will trace the implementation, problems (both technical and administrative), and the current pushback efforts associated with the DOE ''Top-to-Bottom'' review.

  4. Implementation guide for use with suspect/counterfeit items: Requirements of DOE O 440.1, worker protection management; 10 CFR 830.120; and DOE 5700.6C, quality assurance

    SciTech Connect

    1997-06-01

    Department of Energy (DOE) Order (O) 440.1, Worker Protection Management For DOE Federal and Contractors Employees, [7] sets forth requirements for DOE and its contractors to implement suspect and counterfeit items (S/CI) controls as part of the quality assurance (QA) programs required by 10 Code of Federal Regulations (CFR) 830.120 [8] or DOE 5700.6C, Quality Assurance [9]. DOE G-830.120, Implementation Guide for Use with 10 CFR Part 830.120, Quality Assurance, [10] provides additional guidance on establishing and implementing effective QA processes to control S/CIs. DOE O 232.1, Occurrence Reporting and Processing of Operations, [11] specifies requirements for reporting S/CIs under the DOE Occurrence Reporting and Processing System (ORPS). DOE promulgated the requirements and guidance to control or eliminate the hazards posed by S/CIs, which can lead to unexpected equipment failures and undue risks to the DOE mission, the environment, and personnel. This Guide is a compendium of information contained in the referenced DOE directives and other documents concerning S/CI controls. It incorporates, updates, and supersedes earlier guidance issued in Plan for the Suspect/Counterfeit Products Issue in the Department of Energy, dated October 1993, [4] and in memoranda issued by Defense Programs (DP) [12-16] and other DOE program offices. This guidance was developed to strengthen the procurement process, identify and eliminate S/CIs, and improve the reporting of S/CIs. The information in this Guide, when implemented by DOE and its contractors, will satisfy the S/CI requirements contained in the referenced DOE directives.

  5. 13 CFR 123.513 - Does SBA require collateral on its Military Reservist EIDL?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Does SBA require collateral on its Military Reservist EIDL? 123.513 Section 123.513 Business Credit and Assistance SMALL BUSINESS... collateral on its Military Reservist EIDL? SBA will not generally require you to pledge collateral to...

  6. 13 CFR 123.513 - Does SBA require collateral on its Military Reservist EIDL?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Does SBA require collateral on its Military Reservist EIDL? 123.513 Section 123.513 Business Credit and Assistance SMALL BUSINESS... collateral on its Military Reservist EIDL? SBA will not generally require you to pledge collateral to...

  7. 13 CFR 123.513 - Does SBA require collateral on its Military Reservist EIDL?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Does SBA require collateral on its Military Reservist EIDL? 123.513 Section 123.513 Business Credit and Assistance SMALL BUSINESS... collateral on its Military Reservist EIDL? SBA will not generally require you to pledge collateral to...

  8. TA-55 Final Safety Analysis Report Comparison Document and DOE Safety Evaluation Report Requirements

    SciTech Connect

    Alan Bond

    2001-04-01

    This document provides an overview of changes to the currently approved TA-55 Final Safety Analysis Report (FSAR) that are included in the upgraded FSAR. The DOE Safety Evaluation Report (SER) requirements that are incorporated into the upgraded FSAR are briefly discussed to provide the starting point in the FSAR with respect to the SER requirements.

  9. What does education have to do with the New International Economic Order

    NASA Astrophysics Data System (ADS)

    Emmerij, Louis

    1982-12-01

    Greater equality in the distribution of incomes, both nationally and internationally, and more intervention to achieve this, both by national governments and international agencies, are identified as the key ideas in the proposed NIEO. Both ideas have provoked a reaction of new conservatism, aided by the current international recession. At least in part, the power of this reaction is the result of a failure in the educational professions and institutions to respond to the requirements of an NIEO in both domestic and global terms. Although the independent effects of education on social change and income distribution have indeed been over-estimated, it remains true, nevertheless, that education does have social and economic effects. Within states, education might be reorganized so as to dissolve the current dichotomy between a `learning' childhood/adolescence and a `non-learning' adulthood. Rather, learning geared to economic activity, change and restructuring might assist both developing and industrialized states to increase incomes and adjust to the requirements of the NIEO. On the international plane, the growth of development studies and of institutions concerned with the domestic effects of international relations and commerce should facilitate a more informed understanding of the balance between self-reliance and interdependence.

  10. 19 CFR 210.34 - Protective orders; reporting requirement; sanctions and other actions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Protective orders; reporting requirement; sanctions and other actions. 210.34 Section 210.34 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Discovery and Compulsory Process § 210.34 Protective...

  11. 30 CFR 250.177 - What additional requirements may the Regional Supervisor order for a suspension?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... according to 30 CFR part 250, subpart B. Primary Lease Requirements, Lease Term Extensions, and Lease... Supervisor order for a suspension? 250.177 Section 250.177 Mineral Resources BUREAU OF OCEAN ENERGY... must evaluate the cause of the hazard, the potential damage, and the available mitigation measures....

  12. 78 FR 64408 - Watermelon Research and Promotion Plan; Importer Membership Requirements and Referendum Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ...; ] DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 1210 Watermelon Research and Promotion Plan; Importer Membership Requirements and Referendum Order AGENCY: Agricultural Marketing Service... 121, small agricultural producers as those having annual receipts of no more than $750,000 and...

  13. 48 CFR 11.101 - Order of precedence for requirements documents.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Order of precedence for requirements documents. 11.101 Section 11.101 Federal Acquisition Regulations System FEDERAL ACQUISITION... Defense or Federal series for the non-repetitive acquisition of items. (b) In accordance with OMB...

  14. 48 CFR 11.101 - Order of precedence for requirements documents.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Order of precedence for requirements documents. 11.101 Section 11.101 Federal Acquisition Regulations System FEDERAL ACQUISITION... Defense or Federal series for the non-repetitive acquisition of items. (b) In accordance with OMB...

  15. 48 CFR 11.101 - Order of precedence for requirements documents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Order of precedence for requirements documents. 11.101 Section 11.101 Federal Acquisition Regulations System FEDERAL ACQUISITION... Defense or Federal series for the non-repetitive acquisition of items. (b) In accordance with OMB...

  16. Decontaminating the DOE-STD-3013 Inner Container to Meet 10-CFR-835 Appendix D Requirements

    SciTech Connect

    Martinez, H.E.; Nelson, T.O.; Rivera, Y.M.; Wedman, D.E.; Weisbrod, K.R.

    1999-03-03

    The United States Department of Energy (DOE) has published a standard that specifies the criteria for preparation and packaging of plutonium metals and oxides for safe long-term storage (DOE-STD-3013-96). This standard is followed for the packaging of materials resulting from the disassembly of nuclear weapons at Los Alamos National Laboratory under the Advanced Retirement and Integrated Extraction System (ARIES) project. Declassified plutonium metal or oxide material from the ARES project is packaged into doubly contained and welded type 304L stainless steel containers that comply with the DOE standard. The 3013-96 standard describes requirements for maximum contamination limits on the outer surface of the sealed inner container. These limits are 500 dpm per 100 cm2 for direct measurements and 20 dpm per 100 cm2 for removable contamination. For containers filled, welded, and handled inside a highly contaminated glovebox line, these limits are difficult to obtain. Simple handling within the line is demonstrated to contaminate surfaces from 10,000 to 10,000,000 dpm alpha per 100 cm2. To routinely achieve contamination levels below the maximum contamination levels specified by the 3013-96 standard within a processing operation, a decontamination step must be included. In the ARIES line, this decontamination step is an electrolytic process that produces a controlled uniform etch of the container surfaces. Decontamination of the 3013-96 compliant ARIES inner container is well demonstrated. Within 30 to 50 minutes electrolysis time, tixed contamination is reduced to hundreds of dpm generally occurring only at electrode contact points and welds. Removable contamination is routinely brought to non-detectable levels. The total process time for the cycle (includes electrolysis, rinse, and dry stages) is on the order of 1.5 to 2 hours per container. The ARIES inner container decontamination system highly automated and consists of a plumbing loop, electronic controls and

  17. 43 CFR 3195.25 - What information must be in my purchase order/contract for a major helium requirement?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... order/contract for a major helium requirement? 3195.25 Section 3195.25 Public Lands: Interior... MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Agency Requirements § 3195.25 What information must be in my purchase order/contract for a major helium requirement? A purchase order/contract must...

  18. 43 CFR 3195.25 - What information must be in my purchase order/contract for a major helium requirement?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... order/contract for a major helium requirement? 3195.25 Section 3195.25 Public Lands: Interior... MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Agency Requirements § 3195.25 What information must be in my purchase order/contract for a major helium requirement? A purchase order/contract must...

  19. 43 CFR 3195.25 - What information must be in my purchase order/contract for a major helium requirement?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... order/contract for a major helium requirement? 3195.25 Section 3195.25 Public Lands: Interior... MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Agency Requirements § 3195.25 What information must be in my purchase order/contract for a major helium requirement? A purchase order/contract must...

  20. 43 CFR 3195.25 - What information must be in my purchase order/contract for a major helium requirement?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... order/contract for a major helium requirement? 3195.25 Section 3195.25 Public Lands: Interior... MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Agency Requirements § 3195.25 What information must be in my purchase order/contract for a major helium requirement? A purchase order/contract must...

  1. 41 CFR 102-3.185 - What does this subpart require agencies to do?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What does this subpart require agencies to do? 102-3.185 Section 102-3.185 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION GENERAL 3-FEDERAL...

  2. 41 CFR 102-3.185 - What does this subpart require agencies to do?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What does this subpart require agencies to do? 102-3.185 Section 102-3.185 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION GENERAL 3-FEDERAL...

  3. 30 CFR 250.195 - What notification does BSEE require on the production status of wells?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What notification does BSEE require on the production status of wells? 250.195 Section 250.195 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General Information and...

  4. 40 CFR 141.571 - What records does subpart T require my system to keep?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false What records does subpart T require my system to keep? 141.571 Section 141.571 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and Disinfection-Systems Serving Fewer...

  5. 40 CFR 35.4170 - What kinds of reporting does EPA require?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false What kinds of reporting does EPA require? 35.4170 Section 35.4170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Technical Assistance Managing Your...

  6. 21 CFR 1271.45 - What requirements does this subpart contain?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Donor Eligibility § 1271.45 What... 21 Food and Drugs 8 2013-04-01 2013-04-01 false What requirements does this subpart contain? 1271.45 Section 1271.45 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND...

  7. 21 CFR 1271.45 - What requirements does this subpart contain?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Donor Eligibility § 1271.45 What... 21 Food and Drugs 8 2010-04-01 2010-04-01 false What requirements does this subpart contain? 1271.45 Section 1271.45 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND...

  8. 40 CFR 35.4170 - What kinds of reporting does EPA require?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false What kinds of reporting does EPA require? 35.4170 Section 35.4170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Technical Assistance Managing Your...

  9. 40 CFR 35.4170 - What kinds of reporting does EPA require?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false What kinds of reporting does EPA require? 35.4170 Section 35.4170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Technical Assistance Managing Your...

  10. 40 CFR 35.4170 - What kinds of reporting does EPA require?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false What kinds of reporting does EPA require? 35.4170 Section 35.4170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Technical Assistance Managing Your...

  11. 40 CFR 35.4170 - What kinds of reporting does EPA require?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false What kinds of reporting does EPA require? 35.4170 Section 35.4170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Technical Assistance Managing Your...

  12. 41 CFR 102-3.185 - What does this subpart require agencies to do?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What does this subpart require agencies to do? 102-3.185 Section 102-3.185 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION GENERAL 3-FEDERAL...

  13. 12 CFR 617.7630 - Does this Federal requirement affect any state property laws?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... property laws? 617.7630 Section 617.7630 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM BORROWER RIGHTS Right of First Refusal § 617.7630 Does this Federal requirement affect any state property... first refusal under the law of the state in which the property is located....

  14. 12 CFR 617.7630 - Does this Federal requirement affect any state property laws?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... property laws? 617.7630 Section 617.7630 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM BORROWER RIGHTS Right of First Refusal § 617.7630 Does this Federal requirement affect any state property... first refusal under the law of the state in which the property is located....

  15. 12 CFR 617.7630 - Does this Federal requirement affect any state property laws?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... property laws? 617.7630 Section 617.7630 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM BORROWER RIGHTS Right of First Refusal § 617.7630 Does this Federal requirement affect any state property... first refusal under the law of the state in which the property is located....

  16. 12 CFR 617.7630 - Does this Federal requirement affect any state property laws?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... property laws? 617.7630 Section 617.7630 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM BORROWER RIGHTS Right of First Refusal § 617.7630 Does this Federal requirement affect any state property... first refusal under the law of the state in which the property is located....

  17. 12 CFR 617.7630 - Does this Federal requirement affect any state property laws?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... property laws? 617.7630 Section 617.7630 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM BORROWER RIGHTS Right of First Refusal § 617.7630 Does this Federal requirement affect any state property... first refusal under the law of the state in which the property is located....

  18. 40 CFR 141.571 - What records does subpart T require my system to keep?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false What records does subpart T require my system to keep? 141.571 Section 141.571 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and Disinfection-Systems Serving Fewer...

  19. Does computerized provider order entry reduce prescribing errors for hospital inpatients? A systematic review.

    PubMed

    Reckmann, Margaret H; Westbrook, Johanna I; Koh, Yvonne; Lo, Connie; Day, Richard O

    2009-01-01

    Previous reviews have examined evidence of the impact of CPOE on medication errors, but have used highly variable definitions of "error". We attempted to answer a very focused question, namely, what evidence exists that CPOE systems reduce prescribing errors among hospital inpatients? We identified 13 papers (reporting 12 studies) published between 1998 and 2007. Nine demonstrated a significant reduction in prescribing error rates for all or some drug types. Few studies examined changes in error severity, but minor errors were most often reported as decreasing. Several studies reported increases in the rate of duplicate orders and failures to discontinue drugs, often attributed to inappropriate selection from a dropdown menu or to an inability to view all active medication orders concurrently. The evidence-base reporting the effectiveness of CPOE to reduce prescribing errors is not compelling and is limited by modest study sample sizes and designs. Future studies should include larger samples including multiple sites, controlled study designs, and standardized error and severity reporting. The role of decision support in minimizing severe prescribing error rates also requires investigation. PMID:19567798

  20. Do-not-resuscitate orders in the operating room: required reconsideration.

    PubMed

    Smith, K A

    2000-07-01

    Advances in medical technology are giving health care providers the tools with which to keep patients alive for longer and longer periods of time. However, in our struggle to keep patients alive, we must not forget that the patient is the one who controls his or her own destiny. Advance directives and do-not-resuscitate orders are becoming more commonplace as patients strive to make their wishes known to all who care for them. The use of such orders in the operating room has historically been a hotbed of controversy because it appears contrary to the necessity of surgery in the first place. Surgeons, anesthetists, operating room nurses, and others all have concerns regarding this issue, and they will be discussed here. The answer to the dilemma lies in a policy of "required reconsideration" to examine all factors of the do-not-resuscitate order and its applicability to the situation at hand. PMID:10920651

  1. 43 CFR 1822.18 - How does BLM decide in which order to accept documents that are simultaneously filed?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false How does BLM decide in which order to accept documents that are simultaneously filed? 1822.18 Section 1822.18 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) APPLICATION PROCEDURES...

  2. Vacuum-venipuncture skills: time required and importance of tube order

    PubMed Central

    Fujii, Chieko

    2013-01-01

    Background The purpose of this study was to assess specific vacuum-venipuncture skills and the influence of the time involved in skin puncture and blood collection. Methods Thirty subjects undergoing venipuncture in which video analysis was possible were included. These procedures were carried out by four nurses and recorded with a digital camera. Venipuncture skills classified by our observations were delineated on the basis of frame-by-frame video images, and a graph of x and y coordinates was created. Results With the first blood-collection tube, strong blood flow required the practitioner to push the tube back in to compensate for the strong repulsive force in approximately 46% of cases. By the third blood-collection tube, the blood flow had weakened; therefore, the tube was moved up and down. In cases that required a second venipuncture, the tube was already pierced, so the time required to fill it to 5 mL was significantly longer. Conclusion Hand movement of the practitioner is adjusted according to blood flow. Reflex movement in response to strong blood flow may increase the risk of pushing the needle through the vein with excessive force. The time required to fill the tube varies among nurses, tube order, and level of venipuncture skills. PMID:23966786

  3. Higher order thinking skills competencies required by outcomes-based education from learners.

    PubMed

    Chabeli, M M

    2006-08-01

    Outcomes-Based Education (OBE) brought about a significant paradigm shift in the education and training of learners in South Africa. OBE requires a shift from focusing on the teacher input (instruction offerings or syllabuses expressed in terms of content), to focusing on learner outcomes. OBE is moving away from 'transmission' models to constructivistic, learner-centered models that put emphasis on learning as an active process (Nieburh, 1996:30). Teachers act as facilitators and mediators of learning (Norms and Standards, Government Gazette vol 415, no 20844 of 2000). Facilitators are responsible to create the environment that is conducive for learners to construct their own knowledge, skills and values through interaction (Peters, 2000). The first critical cross-field outcome accepted by the South African Qualification Framework (SAQA) is that learners should be able to identify and solve problems by using critical and creative thinking skills. This paper seeks to explore some higher order thinking skills competencies required by OBE from learners such as critical thinking, reflective thinking, creative thinking, dialogic / dialectic thinking, decision making, problem solving and emotional intelligence and their implications in facilitating teaching and learning from the theoretical perspective. The philosophical underpinning of these higher order thinking skills is described to give direction to the study. It is recommended that a study focusing on the assessment of these intellectual concepts be made. The study may be qualitative, quantitative or mixed methods in nature (Creswell 2005). PMID:17131612

  4. 36 CFR 902.51 - Records relating to matters that are required by Executive order to be kept secret.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Order 11652 of March 8, 1972 (3 CFR 1974 Comp. p. 339); (b) Executive Order 10865 of February 20, 1960 (3 CFR 1959-1963 Comp. p. 398); and (c) Executive Order 10104 of February 1, 1950 (3 CFR 1949-1953... that are required by Executive order to be kept secret. 902.51 Section 902.51 Parks, Forests,...

  5. 36 CFR 902.51 - Records relating to matters that are required by Executive order to be kept secret.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Order 11652 of March 8, 1972 (3 CFR 1974 Comp. p. 339); (b) Executive Order 10865 of February 20, 1960 (3 CFR 1959-1963 Comp. p. 398); and (c) Executive Order 10104 of February 1, 1950 (3 CFR 1949-1953... that are required by Executive order to be kept secret. 902.51 Section 902.51 Parks, Forests,...

  6. 36 CFR 902.51 - Records relating to matters that are required by Executive order to be kept secret.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Order 11652 of March 8, 1972 (3 CFR 1974 Comp. p. 339); (b) Executive Order 10865 of February 20, 1960 (3 CFR 1959-1963 Comp. p. 398); and (c) Executive Order 10104 of February 1, 1950 (3 CFR 1949-1953... that are required by Executive order to be kept secret. 902.51 Section 902.51 Parks, Forests,...

  7. 36 CFR 902.51 - Records relating to matters that are required by Executive order to be kept secret.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Order 11652 of March 8, 1972 (3 CFR 1974 Comp. p. 339); (b) Executive Order 10865 of February 20, 1960 (3 CFR 1959-1963 Comp. p. 398); and (c) Executive Order 10104 of February 1, 1950 (3 CFR 1949-1953... that are required by Executive order to be kept secret. 902.51 Section 902.51 Parks, Forests,...

  8. 36 CFR 902.51 - Records relating to matters that are required by Executive order to be kept secret.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Order 11652 of March 8, 1972 (3 CFR 1974 Comp. p. 339); (b) Executive Order 10865 of February 20, 1960 (3 CFR 1959-1963 Comp. p. 398); and (c) Executive Order 10104 of February 1, 1950 (3 CFR 1949-1953... that are required by Executive order to be kept secret. 902.51 Section 902.51 Parks, Forests,...

  9. Guidance document for revision of DOE Order 5820.2A, Radioactive Waste Technical Support Program. Revision 1

    SciTech Connect

    Kudera, D.E.; McMurtrey, C.D.; Meagher, B.G.

    1993-04-01

    This document provides guidance for the revision of DOE Order 5820.2A, ``Radioactive Waste Management.`` Technical Working Groups have been established and are responsible for writing the revised order. The Technical Working Groups will use this document as a reference for polices and procedures that have been established for the revision process. The overall intent of this guidance is to outline how the order will be revised and how the revision process will be managed. In addition, this document outlines technical issues considered for inclusion by a Department of Energy Steering Committee.

  10. 49 CFR 40.208 - What problem requires corrective action but does not result in the cancellation of a test?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What problem requires corrective action but does... of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Problems in Drug Tests § 40.208 What problem requires corrective action but does not result in...

  11. 49 CFR 40.208 - What problem requires corrective action but does not result in the cancellation of a test?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false What problem requires corrective action but does... of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Problems in Drug Tests § 40.208 What problem requires corrective action but does not result in...

  12. Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis

    PubMed Central

    Johnson, Tory A.; Pfeffer, Suzanne R.

    2016-01-01

    Human NPC1L1 protein mediates cholesterol absorption in the intestine and liver and is the target of the drug ezetimibe, which is used to treat hypercholesterolemia. Previous studies concluded that NPC1L1-GFP protein trafficking is regulated by cholesterol binding and that ezetimibe blocks NPC1L1-GFP function by inhibiting its endocytosis. We used cell surface biotinylation to monitor NPC1L1-GFP endocytosis and show that ezetimibe does not alter the rate of NPC1L1-GFP endocytosis in cultured rat hepatocytes grown under normal growth conditions. As expected, NPC1L1-GFP endocytosis depends in part on C-terminal, cytoplasmically oriented sequences, but endocytosis does not require cholesterol binding to NPC1L1’s N-terminal domain. In addition, two small- molecule inhibitors of general (and NPC1L1-GFP) endocytosis failed to inhibit the ezetimibe-sensitive uptake of [3H]cholesterol from taurocholate micelles. These experiments demonstrate that cholesterol uptake by NPC1L1 does not require endocytosis; moreover, ezetimibe interferes with NPC1L1’s cholesterol adsorption activity without blocking NPC1L1 internalization in RH7777 cells. PMID:27075173

  13. Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis.

    PubMed

    Johnson, Tory A; Pfeffer, Suzanne R

    2016-06-01

    Human NPC1L1 protein mediates cholesterol absorption in the intestine and liver and is the target of the drug ezetimibe, which is used to treat hypercholesterolemia. Previous studies concluded that NPC1L1-GFP protein trafficking is regulated by cholesterol binding and that ezetimibe blocks NPC1L1-GFP function by inhibiting its endocytosis. We used cell surface biotinylation to monitor NPC1L1-GFP endocytosis and show that ezetimibe does not alter the rate of NPC1L1-GFP endocytosis in cultured rat hepatocytes grown under normal growth conditions. As expected, NPC1L1-GFP endocytosis depends in part on C-terminal, cytoplasmically oriented sequences, but endocytosis does not require cholesterol binding to NPC1L1's N-terminal domain. In addition, two small- molecule inhibitors of general (and NPC1L1-GFP) endocytosis failed to inhibit the ezetimibe-sensitive uptake of [(3)H]cholesterol from taurocholate micelles. These experiments demonstrate that cholesterol uptake by NPC1L1 does not require endocytosis; moreover, ezetimibe interferes with NPC1L1's cholesterol adsorption activity without blocking NPC1L1 internalization in RH7777 cells. PMID:27075173

  14. DOE Integrated Safeguards and Security (DISS) historical document archival and retrieval analysis, requirements and recommendations

    SciTech Connect

    Guyer, H.B.; McChesney, C.A.

    1994-10-07

    The overall primary Objective of HDAR is to create a repository of historical personnel security documents and provide the functionality needed for archival and retrieval use by other software modules and application users of the DISS/ET system. The software product to be produced from this specification is the Historical Document Archival and Retrieval Subsystem The product will provide the functionality to capture, retrieve and manage documents currently contained in the personnel security folders in DOE Operations Offices vaults at various locations across the United States. The long-term plan for DISS/ET includes the requirement to allow for capture and storage of arbitrary, currently undefined, clearance-related documents that fall outside the scope of the ``cradle-to-grave`` electronic processing provided by DISS/ET. However, this requirement is not within the scope of the requirements specified in this document.

  15. 42 CFR 137.298 - Are Self-Governance Tribes required to comply with Executive Orders to fulfill their...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....298 Are Self-Governance Tribes required to comply with Executive Orders to fulfill their environmental... 42 Public Health 1 2010-10-01 2010-10-01 false Are Self-Governance Tribes required to comply with Executive Orders to fulfill their environmental responsibilities under section 509 of the Act ?...

  16. 48 CFR 8.405-1 - Ordering procedures for supplies, and services not requiring a statement of work.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... supplies, and services not requiring a statement of work. 8.405-1 Section 8.405-1 Federal Acquisition... statement of work. (a) Ordering activities shall use the procedures of this subsection when ordering... specific task, where a statement of work is not required (e.g., installation, maintenance, and repair)....

  17. Using Department of Energy (DOE) Order 435.1 To Find a Cost Effective Waste Management Option. - 12241

    SciTech Connect

    LaBarge, Matt; Frost, Matt

    2012-07-01

    The Depleted Uranium Hexafluoride Project in Portsmouth Ohio was faced with an interesting dilemma. During hot functional testing in August 2010, an upset condition caused gaseous depleted uranium hexafluoride (UF{sub 6}) to come in contact with the hydrofluoric acid (HF) vapor stream. Although the resulting uranium contamination found in the condensed aqueous hydrofluoric acid was very low, it exceeded the Department of Energy (DOE) authorized release limit. After evaluating several commercial options for treatment and disposal using the guidelines found in DOE Order 435.1, Waste Control Specialists LLC was selected for the treatment of the waste, with EnergySolutions' Clive facility selected for disposal of the treated residues. The waste was safely transported from Piketon, Ohio to Andrews, Texas, where it was treated to meet the land Disposal Restrictions (LDR), and was disposed in EnergySolutions operational mixed waste cell. The entire effort was interesting for several reasons. The waste was generated during the last year of the first Depleted Uranium Hexafluoride contractor. The waste became additional scope for the new contractor, adding time delays and introducing new personnel into the project. The effort was also unique because it demonstrated the process mandated by DOE Order 435.1 to evaluate all options, including commercial options, could reveal solutions to waste management problems that are currently available and more cost effective, but not well know within the DOE complex. (authors)

  18. Order short-term memory is not impaired in dyslexia and does not affect orthographic learning

    PubMed Central

    Staels, Eva; Van den Broeck, Wim

    2014-01-01

    This article reports two studies that investigate short-term memory (STM) deficits in dyslexic children and explores the relationship between STM and reading acquisition. In the first experiment, 36 dyslexic children and 61 control children performed an item STM task and a serial order STM task. The results of this experiment show that dyslexic children do not suffer from a specific serial order STM deficit. In addition, the results demonstrate that phonological processing skills are as closely related to both item STM and serial order STM. However, non-verbal intelligence was more strongly involved in serial order STM than in item STM. In the second experiment, the same two STM tasks were administered and reading acquisition was assessed by measuring orthographic learning in a group of 188 children. The results of this study show that orthographic learning is exclusively related to item STM and not to order STM. It is concluded that serial order STM is not the right place to look for a causal explanation of reading disability, nor for differences in word reading acquisition. PMID:25294996

  19. Order short-term memory is not impaired in dyslexia and does not affect orthographic learning.

    PubMed

    Staels, Eva; Van den Broeck, Wim

    2014-01-01

    This article reports two studies that investigate short-term memory (STM) deficits in dyslexic children and explores the relationship between STM and reading acquisition. In the first experiment, 36 dyslexic children and 61 control children performed an item STM task and a serial order STM task. The results of this experiment show that dyslexic children do not suffer from a specific serial order STM deficit. In addition, the results demonstrate that phonological processing skills are as closely related to both item STM and serial order STM. However, non-verbal intelligence was more strongly involved in serial order STM than in item STM. In the second experiment, the same two STM tasks were administered and reading acquisition was assessed by measuring orthographic learning in a group of 188 children. The results of this study show that orthographic learning is exclusively related to item STM and not to order STM. It is concluded that serial order STM is not the right place to look for a causal explanation of reading disability, nor for differences in word reading acquisition. PMID:25294996

  20. Strategy for conducting environmental surveillance of groundwater to comply with DOE orders

    SciTech Connect

    Forstrom, J.M.

    1990-12-01

    This document defines the strategy for conducting environmental surveillance of groundwater quality at Department of Energy (DOE) installations as it will be implemented by Martin Marietta Energy Systems, Inc. The primary objectives of defining this generic strategy prior to developing site-specific plans are to: clearly differentiate between effluent monitoring and environmental surveillance as they apply to groundwater, describe the principles and concepts of groundwater flow that must be considered when establishing a groundwater surveillance program, and provide for a consistent approach to developing plant-specific groundwater surveillance plans. 18 refs., 5 figs., 3 tabs.

  1. 48 CFR 8.405-2 - Ordering procedures for services requiring a statement of work.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... (3) For proposed orders exceeding the maximum order threshold or when establishing a BPA. In addition... is reasonable. Place the order, or establish the BPA, with the schedule contractor that...

  2. DOE nuclear material packaging manual: storage container requirements for plutonium oxide materials

    SciTech Connect

    Veirs, D Kirk

    2009-01-01

    Loss of containment of nuclear material stored in containers such as food-pack cans, paint cans, or taped slip lid cans has generated concern about packaging requirements for interim storage of nuclear materials in working facilities such as the plutonium facility at Los Alamos National Laboratory (LANL). In response, DOE has recently issued DOE M 441.1 'Nuclear Material Packaging Manual' with encouragement from the Defense Nuclear Facilities Safety Board. A unique feature compared to transportation containers is the allowance of filters to vent flammable gases during storage. Defining commonly used concepts such as maximum allowable working pressure and He leak rate criteria become problematic when considering vented containers. Los Alamos has developed a set of container requirements that are in compliance with 441.1 based upon the activity of heat-source plutonium (90% Pu-238) oxide, which bounds the requirements for weapons-grade plutonium oxide. The pre and post drop-test He leak rates depend upon container size as well as the material contents. For containers that are routinely handled, ease of handling and weight are a major consideration. Relatively thin-walled containers with flat bottoms are desired yet they cannot be He leak tested at a differential pressure of one atmosphere due to the potential for plastic deformation of the flat bottom during testing. The He leak rates and He leak testing configuration for containers designed for plutonium bearing materials will be presented. The approach to meeting the other manual requirements such as corrosion and thermal degradation resistance will be addressed. The information presented can be used by other sites to evaluate if their conditions are bounded by LANL requirements when considering procurement of 441.1 compliant containers.

  3. 40 CFR 721.160 - Notification requirements for new chemical substances subject to section 5(e) orders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and other specific requirements for each new chemical substance that is the subject of a final order... substance, unless EPA determines that significant new use notification requirements are not needed for the substance. (2) If EPA determines that significant new use notification requirements are not needed for...

  4. 40 CFR 721.160 - Notification requirements for new chemical substances subject to section 5(e) orders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and other specific requirements for each new chemical substance that is the subject of a final order... substance, unless EPA determines that significant new use notification requirements are not needed for the substance. (2) If EPA determines that significant new use notification requirements are not needed for...

  5. NERSC Cyber Security Challenges That Require DOE Development andSupport

    SciTech Connect

    Draney, Brent; Campbell, Scott; Walter, Howard

    2007-01-16

    Traditional security approaches do not adequately addressall the requirements of open, scientific computing facilities. Many ofthe methods used for more restricted environments, including almost allcorporate/commercial systems, do not meet the needs of today's science.Use of only the available "state of the practice" commercial methods willhave adverse impact on the ability of DOE to accomplish its sciencegoals, and impacts the productivity of the DOE Science community. Inparticular, NERSC and other high performance computing (HPC) centers havespecial security challenges that are unlikely to be met unless DOE fundsdevelopment and support of reliable and effective tools designed to meetthe cyber security needs of High Performance Science. The securitychallenges facing NERSC can be collected into three basic problem sets:network performance and dynamics, application complexity and diversity,and a complex user community that can have transient affiliations withactual institutions. To address these problems, NERSC proposes thefollowing four general solutions: auditing user and system activityacross sites; firewall port configuration in real time;cross-site/virtual organization identity management and access control;and detecting security issues in application middleware. Solutions arealsoproposed for three general long term issues: data volume,application complexity, and information integration.

  6. Does Higher-Order Thinking Impinge on Learner-Centric Digital Approach?

    ERIC Educational Resources Information Center

    Mathew, Bincy; Raja, B. William Dharma

    2015-01-01

    Humans are social beings and the social cognition focuses on how one form impressions of other people, interpret the meaning of other people's behaviour and how people's behaviour is affected by our attitudes. The school provides complex social situations and in order to thrive, students must possess social cognition, the process of thinking about…

  7. Intimate Partner Violence, Relationship Status, and Protective Orders: Does "Living in Sin" Entail a Different Experience?

    ERIC Educational Resources Information Center

    Shannon, Lisa; Logan, T. K.; Cole, Jennifer

    2007-01-01

    The legal status of women's intimate relationships may allow for different experiences with intimate partner violence (IPV) and the protections received from the criminal justice system. There has been limited research examining differences in IPV and protective orders for women in marital and cohabiting intimate relationships. This study examines…

  8. Analysis of waste treatment requirements for DOE mixed wastes: Technical basis

    SciTech Connect

    1995-02-01

    The risks and costs of managing DOE wastes are a direct function of the total quantities of 3wastes that are handled at each step of the management process. As part of the analysis of the management of DOE low-level mixed wastes (LLMW), a reference scheme has been developed for the treatment of these wastes to meet EPA criteria. The treatment analysis in a limited form was also applied to one option for treatment of transuranic wastes. The treatment requirements in all cases analyzed are based on a reference flowsheet which provides high level treatment trains for all LLMW. This report explains the background and basis for that treatment scheme. Reference waste stream chemical compositions and physical properties including densities were established for each stream in the data base. These compositions are used to define the expected behavior for wastes as they pass through the treatment train. Each EPA RCRA waste code was reviewed, the properties, chemical composition, or characteristics which are of importance to waste behavior in treatment were designated. Properties that dictate treatment requirements were then used to develop the treatment trains and identify the unit operations that would be included in these trains. A table was prepared showing a correlation of the waste physical matrix and the waste treatment requirements as a guide to the treatment analysis. The analysis of waste treatment loads is done by assigning wastes to treatment steps which would achieve RCRA compliant treatment. These correlation`s allow one to examine the treatment requirements in a condensed manner and to see that all wastes and contaminant sets are fully considered.

  9. Root growth regulation and gravitropism in maize roots does not require the epidermis

    NASA Technical Reports Server (NTRS)

    Bjorkman, T.; Cleland, R. E.

    1991-01-01

    We have earlier published observations showing that endogenous alterations in growth rate during gravitropism in maize roots (Zea mays L.) are unaffected by the orientation of cuts which remove epidermal and cortical tissue in the growing zone (Bjorkman and Cleland, 1988, Planta 176, 513-518). We concluded that the epidermis and cortex are not essential for transporting a growth-regulating signal in gravitropism or straight growth, nor for regulating the rate of tissue expansion. This conclusion has been challenged by Yang et al. (1990, Planta 180, 530-536), who contend that a shallow girdle around the entire perimeter of the root blocks gravitropic curvature and that this inhibition is the result of a requirement for epidermal cells to transport the growth-regulating signal. In this paper we demonstrate that the entire epidermis can be removed without blocking gravitropic curvature and show that the position of narrow girdles does not affect the location of curvature. We therefore conclude that the epidermis is not required for transport of a growth-regulating substance from the root cap to the growing zone, nor does it regulate the growth rate of the elongating zone of roots.

  10. The order of concurrent training does not affect soccer-related performance adaptations.

    PubMed

    McGawley, K; Andersson, P-I

    2013-11-01

    Despite the wealth of evidence regarding physical training strategies in soccer, there is little information regarding soccer-specific concurrent training and the effects of training order. The current study aimed to: i) quantify the effects of concurrent high-intensity run-based training (HIT) and strength- and power-based training (STR) on soccer-specific performance, and ii) investigate the order effect of completing HIT and STR either first or second within training sessions. Eighteen semi- and fully-professional players completed a battery of field- and gym-based tests before and after a 5-week pre-season training intervention. Players were pair-matched and completed 3 sessions per week of HIT followed by STR (n=9) or STR followed by HIT (n=9). ANCOVA tests revealed no differences between groups for changes in any of the measures (p>0.05). However, a training effect was observed for all measures (p<0.05), with 10-m sprint, 6×30-m repeated sprint, 40-m agility and Yo-Yo test performances improving by 1.8±2.6%, 1.3±1.8%, 1.0±1.5% and 19.4±23.4%, respectively (n=18). In conclusion, there was a positive effect of the concurrent training approach on key measures of soccer performance, but the order of completing HIT and STR appears inconsequential to performance adaptations. PMID:23700329

  11. Integrating NEPA (National Environmental Policy Act) and CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act) requirements during remedial responses at DOE facilities

    SciTech Connect

    Levine, M.B.; Smith, E.D.; Sharples, F.E.; Eddlemon, G.K.

    1990-07-01

    US Department of Energy (DOE) Order 5400.4, issued October 6, 1989, calls for integrating the requirements of the National Environmental Policy Act (NEPA) with those of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) for DOE remedial actions under CERCLA. CERCLA requires that decisions on site remediation be made through a formal process called a Remedial Investigation/Feasibility Study (RI/FS). According to the DOE order, integration is to be accomplished by conducting the NEPA and CERCLA environmental planning and review procedures concurrently. The primary instrument for integrating the processes is to be the RI/FS process, which will be supplemented as needed to meet the procedural and documentational requirements of NEPA. The final product of the integrated process will be a single, integrated set of documents; namely, an RI report and an FS-EIS that satisfy the requirements of both NEPA and CERCLA. The contents of the report include (1) an overview and comparison of the requirements of the two processes; (2) descriptions of the major tasks included in the integrated RI/FS-EIS process; (3) recommended contents for integrated RI/FS-EIS documents; and (4)a discussion of some potential problems in integrating NEPA and CERCLA that fall outisde the scope of the RI/FS-EIS process, with suggestions for resolving some of these problems. 15 refs.

  12. 40 CFR 141.522 - How does the State determine whether my system's watershed control requirements are adequate?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... my system's watershed control requirements are adequate? 141.522 Section 141.522 Protection of... Additional Watershed Control Requirements for Unfiltered Systems § 141.522 How does the State determine whether my system's watershed control requirements are adequate? During an onsite inspection...

  13. 40 CFR 141.522 - How does the State determine whether my system's watershed control requirements are adequate?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... my system's watershed control requirements are adequate? 141.522 Section 141.522 Protection of... Additional Watershed Control Requirements for Unfiltered Systems § 141.522 How does the State determine whether my system's watershed control requirements are adequate? During an onsite inspection...

  14. 40 CFR 141.522 - How does the State determine whether my system's watershed control requirements are adequate?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... my system's watershed control requirements are adequate? 141.522 Section 141.522 Protection of... Additional Watershed Control Requirements for Unfiltered Systems § 141.522 How does the State determine whether my system's watershed control requirements are adequate? During an onsite inspection...

  15. 40 CFR 141.522 - How does the State determine whether my system's watershed control requirements are adequate?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... my system's watershed control requirements are adequate? 141.522 Section 141.522 Protection of... Additional Watershed Control Requirements for Unfiltered Systems § 141.522 How does the State determine whether my system's watershed control requirements are adequate? During an onsite inspection...

  16. 40 CFR 141.522 - How does the State determine whether my system's watershed control requirements are adequate?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... my system's watershed control requirements are adequate? 141.522 Section 141.522 Protection of... Additional Watershed Control Requirements for Unfiltered Systems § 141.522 How does the State determine whether my system's watershed control requirements are adequate? During an onsite inspection...

  17. How does participation in inquiry-based activities influence gifted students' higher order thinking?

    NASA Astrophysics Data System (ADS)

    Reger, Barbara H.

    Inquiry-based learning is considered a useful technique to strengthen the critical thinking skills of students. The National Science Standards emphasize its use and the complexities and challenge it provides are well suited for meeting the needs of the gifted. While many studies have documented the effectiveness of this type of instruction, there is a lack of research on growth in higher-order thinking through participation in science inquiry. This study investigated such growth among a small group of gifted fifth-grade students. In this study a group of fifth-grade gifted science students completed a series of three forensics inquiry lessons, and documented questions, ideas and reflections as they constructed evidence to solve a crime. From this class of students, one small group was purposely selected to serve as the focus of the study. Using qualitative techniques, the questions and statements students made as they interacted in the activity were analyzed. Videotaped comments and student logs were coded for emerging patterns and also examined for evidence of increased levels of higher-order thinking based on a rubric that was designed using the six levels of Bloom's Taxonomy. Evidence from this study showed marked increase in and deeper levels of higher-order thinking for two of the students. The other boy and girl showed progress using the inquiry activities, but it was not as evident. The social dynamics of the group seemed to hinder one girl's participation during some of the activities. The social interactions played a role in strengthening the exchange of ideas and thinking skills for the others. The teacher had a tremendous influence over the production of higher-level statements by modeling that level of thinking as she questioned the students. Through her practice of answering a question with a question, she gradually solicited more analytical thinking from her students.

  18. 20 CFR 667.820 - What authority does the Administrative Law Judge have in ordering relief as an outcome of an...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What authority does the Administrative Law Judge have in ordering relief as an outcome of an administrative hearing? 667.820 Section 667.820... What authority does the Administrative Law Judge have in ordering relief as an outcome of...

  19. 34 CFR 403.184 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... APPLIED TECHNOLOGY EDUCATION PROGRAM What Financial Conditions Must Be Met by a State? § 403.184 How does... 34 Education 3 2013-07-01 2013-07-01 false How does a State request a waiver of the maintenance of effort requirement? 403.184 Section 403.184 Education Regulations of the Offices of the Department...

  20. 34 CFR 403.184 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... APPLIED TECHNOLOGY EDUCATION PROGRAM What Financial Conditions Must Be Met by a State? § 403.184 How does... 34 Education 3 2012-07-01 2012-07-01 false How does a State request a waiver of the maintenance of effort requirement? 403.184 Section 403.184 Education Regulations of the Offices of the Department...

  1. 34 CFR 403.184 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... APPLIED TECHNOLOGY EDUCATION PROGRAM What Financial Conditions Must Be Met by a State? § 403.184 How does... 34 Education 3 2014-07-01 2014-07-01 false How does a State request a waiver of the maintenance of effort requirement? 403.184 Section 403.184 Education Regulations of the Offices of the Department...

  2. 34 CFR 403.184 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... APPLIED TECHNOLOGY EDUCATION PROGRAM What Financial Conditions Must Be Met by a State? § 403.184 How does... 34 Education 3 2011-07-01 2011-07-01 false How does a State request a waiver of the maintenance of effort requirement? 403.184 Section 403.184 Education Regulations of the Offices of the Department...

  3. 20 CFR 411.410 - Does each referral from an EN to a State VR agency require its own agreement?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Does each referral from an EN to a State VR agency require its own agreement? 411.410 Section 411.410 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.410 Does each referral from...

  4. 20 CFR 411.410 - Does each referral from an EN to a State VR agency require its own agreement?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Does each referral from an EN to a State VR agency require its own agreement? 411.410 Section 411.410 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.410 Does each referral from...

  5. 20 CFR 411.410 - Does each referral from an EN to a State VR agency require its own agreement?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Does each referral from an EN to a State VR agency require its own agreement? 411.410 Section 411.410 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.410 Does each referral from...

  6. 20 CFR 411.410 - Does each referral from an EN to a State VR agency require its own agreement?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Does each referral from an EN to a State VR agency require its own agreement? 411.410 Section 411.410 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.410 Does each referral from...

  7. 34 CFR 403.184 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... APPLIED TECHNOLOGY EDUCATION PROGRAM What Financial Conditions Must Be Met by a State? § 403.184 How does... 34 Education 3 2010-07-01 2010-07-01 false How does a State request a waiver of the maintenance of effort requirement? 403.184 Section 403.184 Education Regulations of the Offices of the Department...

  8. 20 CFR 411.410 - Does each referral from an EN to a State VR agency require its own agreement?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Does each referral from an EN to a State VR...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.410 Does each referral from an EN to a State VR agency require its own agreement? No. The agreements between ENs and State...

  9. 10 CFR 727.5 - What acknowledgment and consent is required for access to information on DOE computers?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... information on DOE computers? 727.5 Section 727.5 Energy DEPARTMENT OF ENERGY CONSENT FOR ACCESS TO INFORMATION ON DEPARTMENT OF ENERGY COMPUTERS § 727.5 What acknowledgment and consent is required for access to information on DOE computers? An individual may not be granted access to information on a...

  10. 10 CFR 727.5 - What acknowledgment and consent is required for access to information on DOE computers?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... information on DOE computers? 727.5 Section 727.5 Energy DEPARTMENT OF ENERGY CONSENT FOR ACCESS TO INFORMATION ON DEPARTMENT OF ENERGY COMPUTERS § 727.5 What acknowledgment and consent is required for access to information on DOE computers? An individual may not be granted access to information on a...

  11. 10 CFR 727.5 - What acknowledgment and consent is required for access to information on DOE computers?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... information on DOE computers? 727.5 Section 727.5 Energy DEPARTMENT OF ENERGY CONSENT FOR ACCESS TO INFORMATION ON DEPARTMENT OF ENERGY COMPUTERS § 727.5 What acknowledgment and consent is required for access to information on DOE computers? An individual may not be granted access to information on a...

  12. 10 CFR 727.5 - What acknowledgment and consent is required for access to information on DOE computers?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... information on DOE computers? 727.5 Section 727.5 Energy DEPARTMENT OF ENERGY CONSENT FOR ACCESS TO INFORMATION ON DEPARTMENT OF ENERGY COMPUTERS § 727.5 What acknowledgment and consent is required for access to information on DOE computers? An individual may not be granted access to information on a...

  13. 10 CFR 727.5 - What acknowledgment and consent is required for access to information on DOE computers?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... information on DOE computers? 727.5 Section 727.5 Energy DEPARTMENT OF ENERGY CONSENT FOR ACCESS TO INFORMATION ON DEPARTMENT OF ENERGY COMPUTERS § 727.5 What acknowledgment and consent is required for access to information on DOE computers? An individual may not be granted access to information on a...

  14. A reverse order interview does not aid deception detection regarding intentions

    PubMed Central

    Fenn, Elise; McGuire, Mollie; Langben, Sara; Blandón-Gitlin, Iris

    2015-01-01

    Promising recent research suggests that more cognitively demanding interviews improve deception detection accuracy. Would these cognitively demanding techniques work in the same way when discriminating between true and false future intentions? In Experiment 1 participants planned to complete a task, but instead were intercepted and interviewed about their intentions. Participants lied or told the truth, and were subjected to high (reverse order) or low (sequential order) cognitive load interviews. Third-party observers watched these interviews and indicated whether they thought the person was lying or telling the truth. Subjecting participants to a reverse compared to sequential interview increased the misidentification rate and the appearance of cognitive load in truth tellers. People lying about false intentions were not better identified. In Experiment 2, a second set of third-party observers rated behavioral cues. Consistent with Experiment 1, truth tellers, but not liars, exhibited more behaviors associated with lying and fewer behaviors associated with truth telling in the reverse than sequential interview. Together these results suggest that certain cognitively demanding interviews may be less useful when interviewing to detect false intentions. Explaining a true intention while under higher cognitive demand places truth tellers at risk of being misclassified. There may be such a thing as too much cognitive load induced by certain techniques PMID:26379610

  15. 10 CFR 820.23 - Consent order.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... consistent with the objectives of the Act and the DOE Nuclear Safety Requirements. The Director and a person... Consent Order need not constitute an admission by any person that the Act or a DOE Nuclear Safety... Act or a DOE Nuclear Safety Requirement. A Consent Order shall, however, set forth the relevant...

  16. An in fiber experimental approach to photonic quantum digital signatures that does not require quantum memory

    NASA Astrophysics Data System (ADS)

    Collins, Robert J.; Donaldon, Ross J.; Dunjko, Vedran; Wallden, Petros; Clarke, Patrick J.; Andersson, Erika; Jeffers, John; Buller, Gerald S.

    2014-10-01

    Classical digital signatures are commonly used in e-mail, electronic financial transactions and other forms of electronic communications to ensure that messages have not been tampered with in transit, and that messages are transferrable. The security of commonly used classical digital signature schemes relies on the computational difficulty of inverting certain mathematical functions. However, at present, there are no such one-way functions which have been proven to be hard to invert. With enough computational resources certain implementations of classical public key cryptosystems can be, and have been, broken with current technology. It is nevertheless possible to construct information-theoretically secure signature schemes, including quantum digital signature schemes. Quantum signature schemes can be made information theoretically secure based on the laws of quantum mechanics, while classical comparable protocols require additional resources such as secret communication and a trusted authority. Early demonstrations of quantum digital signatures required quantum memory, rendering them impractical at present. Our present implementation is based on a protocol that does not require quantum memory. It also uses the new technique of unambiguous quantum state elimination, Here we report experimental results for a test-bed system, recorded with a variety of different operating parameters, along with a discussion of aspects of the system security.

  17. 39 CFR 762.42 - Request for substitute disbursement postal money orders; requirements for undertaking of indemnity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Request for substitute disbursement postal money orders; requirements for undertaking of indemnity. 762.42 Section 762.42 Postal Service UNITED STATES POSTAL SERVICE POSTAL SERVICE DEBT OBLIGATIONS; DISBURSEMENT POSTAL MONEY ORDERS DISBURSEMENT...

  18. 39 CFR 762.42 - Request for substitute disbursement postal money orders; requirements for undertaking of indemnity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Request for substitute disbursement postal money orders; requirements for undertaking of indemnity. 762.42 Section 762.42 Postal Service UNITED STATES POSTAL SERVICE POSTAL SERVICE DEBT OBLIGATIONS; DISBURSEMENT POSTAL MONEY ORDERS DISBURSEMENT...

  19. 39 CFR 762.42 - Request for substitute disbursement postal money orders; requirements for undertaking of indemnity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Request for substitute disbursement postal money orders; requirements for undertaking of indemnity. 762.42 Section 762.42 Postal Service UNITED STATES POSTAL SERVICE POSTAL SERVICE DEBT OBLIGATIONS; DISBURSEMENT POSTAL MONEY ORDERS DISBURSEMENT...

  20. 39 CFR 762.42 - Request for substitute disbursement postal money orders; requirements for undertaking of indemnity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Request for substitute disbursement postal money orders; requirements for undertaking of indemnity. 762.42 Section 762.42 Postal Service UNITED STATES POSTAL SERVICE POSTAL SERVICE DEBT OBLIGATIONS; DISBURSEMENT POSTAL MONEY ORDERS DISBURSEMENT...

  1. 39 CFR 762.42 - Request for substitute disbursement postal money orders; requirements for undertaking of indemnity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Request for substitute disbursement postal money orders; requirements for undertaking of indemnity. 762.42 Section 762.42 Postal Service UNITED STATES POSTAL SERVICE POSTAL SERVICE DEBT OBLIGATIONS; DISBURSEMENT POSTAL MONEY ORDERS DISBURSEMENT...

  2. Bcl-2 does not require Raf kinase activity for its death-protective function.

    PubMed Central

    Olivier, R; Otter, I; Monney, L; Wartmann, M; Borner, C

    1997-01-01

    It has been widely accepted that the oncogene product bcl-2 protects mammalian cells from programmed cell death (apoptosis). The molecules and signalling pathways upon which bcl-2 acts are, however, still ill-defined. Recently, bcl-2 was shown to interact with c-raf-1 in vitro. Furthermore, an active form of c-raf-1 delayed apoptosis induced by trophic factor deprivation and enhanced the death-suppressive function of bcl-2 when co-expressed. This has led to the hypothesis that bcl-2 communicates cell-death protection via a raf-dependent signal transduction pathway. Here we show, by various immunological and biochemical methods, that bcl-2 does not stably associate with c-raf-1 in cellular extracts prepared from fibroblasts before or after treatment with agents that induce apoptosis. Unexpectedly, bcl-2 function is entirely maintained, if not improved, when raf-dependent signalling is experimentally abrogated. In fact, bcl-2 allows the stable overexpression of a kinase-defective dominant-negative raf mutant that usually interferes with cell viability and/or proliferation. Our results indicate that bcl-2 does not require c-raf-1 kinase activity and an associated mitogen-activated protein kinase signalling pathway for its survival function. This property may be exploited to dissect cellular events that are dependent or independent of c-raf-1 kinase activity. PMID:9164843

  3. Posttraumatic stress disorder and alcohol dependence: does order of onset make a difference?

    PubMed

    McLean, Carmen P; Su, Yi-Jen; Foa, Edna B

    2014-12-01

    Posttraumatic stress disorder (PTSD) and alcohol dependence (AD) are frequently comorbid and the order in which they develop may affect the clinical presentation and response to treatment. This study compared 73 treatment-seeking participants who developed PTSD prior to developing AD ("PTSD-first") with 64 participants who developed AD prior to developing PTSD ("AD-first") on demographics, clinical presentation, and response to treatment for PTSD and AD. All participants received BRENDA, a medication management and motivational enhancement intervention and were randomly assigned to either prolonged exposure (PE) for PTSD plus BRENDA or BRENDA alone and to either naltrexone (NAL) for AD or placebo (PBO). Results showed that participants with AD-first were more likely to report low income, meet criteria for antisocial or borderline personality disorder, report an index trauma of physical assault, compared to those with PTSD-first. Conversely, participants with PTSD-first were more likely to report an index trauma of sexual assault or a combat experience. Notably, no group differences were observed in treatment outcome despite some differences in clinical presentation. PMID:25445079

  4. [Clinical evaluation of an oxygen concentrator and humidifier that does not require additional reservoir water].

    PubMed

    Burioka, Naoto; Nakamoto, Sachiko; Fukuoka, Yasushi; Shimizu, Eiji

    2011-02-01

    A conventional humidifier with a reservoir of water for humidification can produce micro-aerosols contaminated with bacteria. The present study was undertaken to determine the clinical efficiency of a membrane humidifier that does not require additional reservoir water. We analyzed relative room air humidity and oxygen levels obtained from 2 pressure-swing adsorption (PSA)-type oxygen concentrators with membrane humidifiers. A significant correlation was found between relative room air humidity and that of oxygen moistened by a membrane humidifier. Several patients with chronic respiratory failure experienced improvements in subjectively reported nasal dryness using an oxygen concentrator with a membrane humidifier. This device avoids the need to change reservoir water, and may improve patient quality of life in the home. PMID:21400902

  5. 76 FR 11529 - Gregory Desobry, Ph.D.; Order Requiring Notification of Involvement in NRC-Licensed Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ... accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires... COMMISSION Gregory Desobry, Ph.D.; Order Requiring Notification of Involvement in NRC-Licensed Activities I... Mr. Desobry, Ph.D., requests a hearing, that person shall set forth with particularity the manner...

  6. 21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Requirements for storing and using a private key... Certificates for Electronic Orders § 1311.30 Requirements for storing and using a private key for digitally... private key. (b) The certificate holder must provide FIPS-approved secure storage for the private key,...

  7. 21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Requirements for storing and using a private key... Certificates for Electronic Orders § 1311.30 Requirements for storing and using a private key for digitally... private key. (b) The certificate holder must provide FIPS-approved secure storage for the private key,...

  8. 21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Requirements for storing and using a private key... Certificates for Electronic Orders § 1311.30 Requirements for storing and using a private key for digitally... private key. (b) The certificate holder must provide FIPS-approved secure storage for the private key,...

  9. 21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Requirements for storing and using a private key... Certificates for Electronic Orders § 1311.30 Requirements for storing and using a private key for digitally... private key. (b) The certificate holder must provide FIPS-approved secure storage for the private key,...

  10. 21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Requirements for storing and using a private key... Digital Certificates for Electronic Orders § 1311.30 Requirements for storing and using a private key for... and private key. (b) The certificate holder must provide FIPS-approved secure storage for the...

  11. 10 CFR 820.42 - Final order.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Final order. 820.42 Section 820.42 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES Compliance Orders § 820.42 Final order. A Compliance Order is a Final Order that constitutes a DOE Nuclear Safety Requirement that is effective...

  12. 10 CFR 820.42 - Final order.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Final order. 820.42 Section 820.42 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES Compliance Orders § 820.42 Final order. A Compliance Order is a Final Order that constitutes a DOE Nuclear Safety Requirement that is effective...

  13. 21 CFR 1311.55 - Requirements for systems used to process digitally signed orders.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... private key from the system memory to prevent the unauthorized access to, or use of, the private key. (7... certificate holder and recipient of an electronic order may use any system to write, track, or maintain orders provided that the system has been enabled to process digitally signed documents and that it meets...

  14. 21 CFR 1311.55 - Requirements for systems used to process digitally signed orders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... private key from the system memory to prevent the unauthorized access to, or use of, the private key. (7... certificate holder and recipient of an electronic order may use any system to write, track, or maintain orders provided that the system has been enabled to process digitally signed documents and that it meets...

  15. 21 CFR 1311.55 - Requirements for systems used to process digitally signed orders.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... private key from the system memory to prevent the unauthorized access to, or use of, the private key. (7... certificate holder and recipient of an electronic order may use any system to write, track, or maintain orders provided that the system has been enabled to process digitally signed documents and that it meets...

  16. 21 CFR 1311.55 - Requirements for systems used to process digitally signed orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... deactivated, the system must clear the plain text private key from the system memory to prevent the.... (a) A CSOS certificate holder and recipient of an electronic order may use any system to write, track, or maintain orders provided that the system has been enabled to process digitally signed...

  17. 19 CFR 210.34 - Protective orders; reporting requirement; sanctions and other actions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...; sanctions and other actions. 210.34 Section 210.34 Customs Duties UNITED STATES INTERNATIONAL TRADE...) Issuance of protective order. Upon motion by a party or by the person from whom discovery is sought or by... judge may make any order that may appear necessary and appropriate for the protection of the...

  18. 19 CFR 210.34 - Protective orders; reporting requirement; sanctions and other actions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...; sanctions and other actions. 210.34 Section 210.34 Customs Duties UNITED STATES INTERNATIONAL TRADE...) Issuance of protective order. Upon motion by a party or by the person from whom discovery is sought or by... judge may make any order that may appear necessary and appropriate for the protection of the...

  19. 19 CFR 210.34 - Protective orders; reporting requirement; sanctions and other actions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...; sanctions and other actions. 210.34 Section 210.34 Customs Duties UNITED STATES INTERNATIONAL TRADE...) Issuance of protective order. Upon motion by a party or by the person from whom discovery is sought or by... judge may make any order that may appear necessary and appropriate for the protection of the...

  20. 19 CFR 210.34 - Protective orders; reporting requirement; sanctions and other actions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...; sanctions and other actions. 210.34 Section 210.34 Customs Duties UNITED STATES INTERNATIONAL TRADE...) Issuance of protective order. Upon motion by a party or by the person from whom discovery is sought or by... judge may make any order that may appear necessary and appropriate for the protection of the...

  1. Epidural fentanyl does not influence intravenous PCA requirements in the post-caesarean patient.

    PubMed

    Sevarino, F B; McFarlane, C; Sinatra, R S

    1991-05-01

    Forty ASA physical status I or II patients scheduled for elective Caesarean delivery were studied to determine the effect of epidural fentanyl on post-Caesarean delivery analgesic requirements as administered by intravenous patient-controlled analgesia (PCA). Following delivery of the infant, under epidural anaesthesia with lidocaine 2% with 1/200,000 epinephrine, patients were randomly assigned to receive either 10 ml of preservative-free normal saline via the epidural catheter or 100 micrograms of fentanyl with 8 ml preservative-free normal saline in a double-blinded fashion. On arrival in the post-anesthesia recovery room (PAR), patients were provided with intravenous PCA meperidine 12.5 mg every eight minutes as needed. Patients were visited at intervals over the next 24 hr to determine if any differences in narcotic requirements, demands for narcotics, or severity of pain were noted. No differences were observed in any values between the groups. It is concluded that a single bolus of epidural fentanyl does not provide an advantage for postoperative pain relief in this patient population. PMID:2065412

  2. Mandatory continuing professional development requirements: what does this mean for Australian nurses

    PubMed Central

    2013-01-01

    Background This paper presents a discussion related to the recent decision in Australia to introduce mandatory Continuing Professional Development (CPD) for nurses. Historically there has been international debate surrounding mandatory CPD requirements; this debate is ongoing as Australian nurses face a diverse range of CPD offerings from a variety of providers. Discussion The purpose of this paper is to examine how mandatory CPD requirements for national nursing registration in Australia have evolved and to present an analysis of what this will mean for Australian nurses. What is yet to be determined is how to measure professional development and the effectiveness of professional development education. This is important to the international community with consensus in the literature that professional development is linked to ongoing education. Contradicting arguments are presented about whether this professional development should be mandatory. Summary Presenting a contemporary discussion about the current and potential impact of mandatory CPD requirements for nurses, this discussion paper utilises the case of Australia’s current national policy and CPD operation to examine the choices that nurses make in order to fulfil their legislative requirements. Additional arguments are presented about the barriers nurses face in undertaking CPD. The quest for effective CPD is complex and should incorporate different situations for nurses and individual learning styles. PMID:23537293

  3. 36 CFR 1234.22 - How does an agency request a waiver from a requirement in this part?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... waiver from a requirement in this part? 1234.22 Section 1234.22 Parks, Forests, and Public Property... FACILITIES Handling Deviations From NARA's Facility Standards § 1234.22 How does an agency request a waiver... September 28, 2005; and (3) The application of roof requirements in §§ 1234.10 and 1234.12 to...

  4. 40 CFR 51.10 - How does my state report emissions that are required by the NOX SIP Call?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... are required by the NOX SIP Call? 51.10 Section 51.10 Protection of Environment ENVIRONMENTAL... does my state report emissions that are required by the NOX SIP Call? The District of Columbia and states that are subject to the NOX SIP Call § 51.121) are subject to the emissions reporting...

  5. 40 CFR 51.10 - How does my state report emissions that are required by the NOX SIP Call?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... are required by the NOX SIP Call? 51.10 Section 51.10 Protection of Environment ENVIRONMENTAL... does my state report emissions that are required by the NOX SIP Call? The District of Columbia and states that are subject to the NOX SIP Call § 51.121) are subject to the emissions reporting...

  6. 24 CFR 1000.242 - When does the requirement for exemption from taxation apply to affordable housing activities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... exemption from taxation apply to affordable housing activities? 1000.242 Section 1000.242 Housing and Urban... ACTIVITIES Indian Housing Plan (IHP) § 1000.242 When does the requirement for exemption from taxation apply to affordable housing activities? The requirement for exemption from taxation applies only to...

  7. Does the Chemical Diversity of the Order Haplosclerida (Phylum Porifera: Class Demospongia) Fit with Current Taxonomic Classification?

    PubMed

    Tribalat, Marie-Aude; Marra, Maria V; McCormack, Grace P; Thomas, Olivier P

    2016-06-01

    Sponges and their associated microbiota are well known to produce a large diversity of natural products, also called specialized metabolites. In addition to their potential use in the pharmaceutical industry, these rather species-specific compounds may help in the classification of some particular sponge groups. We review herein compounds isolated from haplosclerid sponges (Class Demospongia, Order Haplosclerida) in order to help in the revision of this large group of marine invertebrates. We focus only on 3-alkylpyridine derivatives and polyacetylenic compounds, as these two groups of natural products are characteristic of haplosclerid species and are highly diverse. A close collaboration between chemists and biologists is required in order to fully apply chemotaxonomical approaches, and whenever possible biological data should include morphological and molecular data and some insight into their microbial abundance. PMID:27135628

  8. H19ICR mediated transcriptional silencing does not require target promoter methylation.

    PubMed

    Gebert, Claudia; Rong, Qi; Jeong, Sangkyun; Iben, James; Pfeifer, Karl

    2016-07-29

    Transcription of the reciprocally imprinted genes Insulin-like growth factor 2 (Igf2) and H19 is orchestrated by the 2.4-kb H19 Imprinting Control Region (H19ICR) located upstream of H19. Three known functions are associated with the H19ICR: (1) it is a germline differentially methylated region, (2) it is a transcriptional insulator, and (3) it is a transcriptional silencer. The molecular mechanisms of the DMR and insulator functions have been well characterized but the basis for the ICR's silencer function is less well understood. In order to study the role the H19ICR intrinsically plays in gene silencing, we transferred the 2.4-kb H19ICR to a heterologous non-imprinted location on chromosome 5, upstream of the alpha fetoprotein (Afp) promoter. Independent of its orientation, the 2.4-kb H19ICR silences transcription from the paternal Afp promoter. Thus silencing is a function intrinsic to this DNA element. Further, ICR mediated silencing is a developmental process that, unexpectedly, does not occur through DNA methylation at the target promoter. PMID:27178213

  9. EVALUATION OF STATE-OF-THE-ART MANIPULATORS AND REQUIREMENTS FOR DOE ROBOTICS APPLICATIONS

    SciTech Connect

    BLACK, DEREK; GRUPINSKI, STEPHEN

    1998-10-08

    This report provides an overview of applications within the DOE complex which could benefit from the use of modular robotics technology during remediation operations. Each application area contains one or more specific tasks which are presently conducted by humans under hazardous conditions or which are deemed highly impractical, or are altogether impossible without automation. Five major areas were investigated for specific needs with respect to automation. Information was collected on Mixed Waste Operations, Contaminant Automated Analysis, Tanks, Decontamination and Dismantlement and Automated Plutonium Processing. During this investigation, information was gathered from available literature, telephone interviews with informed personnel and on-site visits. This data serves to provide design requirements and guidelines for the design of a family of modular actuators, which will be used to construct manipulators suited to each task. In addition, a survey of existing modular manipulator designs is presented. This survey addresses modular manipulators developed inside government labs and in universities for such applications as space exploration or controls research. It also addresses efforts at commercially viable industrial manipulators which have been built. This survey of robotic systems provides the reader with a glimpse into what technology currently exists in the way of modular manipulator automation and, to a degree, where this technology may be applicable or, more often, where these systems are unsuited to EM applications. From the information gathered during this study, it is possible to sufficiently define the requirements of one manipulator system which can be used to conduct automated transfer operations within Plutonium gloveboxes. This manipulator will be constructed from ARM Automation actuator modules and will provide this application with a viable option for automation within these gloveboxes. The design issues surrounding this manipulator and its

  10. Sustainable institutionalized punishment requires elimination of second-order free-riders

    NASA Astrophysics Data System (ADS)

    Perc, Matjaž

    2012-03-01

    Although empirical and theoretical studies affirm that punishment can elevate collaborative efforts, its emergence and stability remain elusive. By peer-punishment the sanctioning is something an individual elects to do depending on the strategies in its neighborhood. The consequences of unsustainable efforts are therefore local. By pool-punishment, on the other hand, where resources for sanctioning are committed in advance and at large, the notion of sustainability has greater significance. In a population with free-riders, punishers must be strong in numbers to keep the ``punishment pool'' from emptying. Failure to do so renders the concept of institutionalized sanctioning futile. We show that pool-punishment in structured populations is sustainable, but only if second-order free-riders are sanctioned as well, and to a such degree that they cannot prevail. A discontinuous phase transition leads to an outbreak of sustainability when punishers subvert second-order free-riders in the competition against defectors.

  11. TYLCV-Is movement in planta does not require V2 protein

    SciTech Connect

    Hak, Hagit; Levy, Yael; Chandran, Sam A.; Belausov, Eduard; Loyter, Abraham; Lapidot, Moshe; Gafni, Yedidya

    2015-03-15

    Tomato yellow leaf curl virus (TYLCV), a major tomato pathogen causing extensive crop losses, is a whitefly-transmitted geminivirus. V2 mutants of TYLCV-Is and related viruses tend to induce symptomless infection with attenuated viral DNA levels, while accumulating close to wild-type DNA levels in protoplasts, suggesting V2 as a movement protein. The discovery of plant-silencing mechanisms and viral silencing suppressors, V2 included, led us to reconsider V2's involvement in viral movement. We studied two mutant versions of the virus, one impaired in V2 silencing-suppression activity, and another carrying a non-translatable V2. While both mutant viruses spread in the infected plant to newly emerged leaves at the same rate as the wild-type virus, their DNA-accumulation levels were tenfold lower than in the wild-type virus. Thus, we suggest that the setback in virus proliferation, previously ascribed to a movement impediment, is due to lack of silencing-suppression activity. - Highlights: • TYLCV-Is V2 protein is localized in distinct microbodies throughout the cell cytoplasm, around the nucleus and in association with cytoplasmic strands but is not associated with the plasmodesmata. • Disruption of RNA-silencing suppression activity of TYLCV-Is V2 protein causes low titer of the virus in the infected plants. • The movement of TYLCV-Is in planta does not require a functional V2 protein.

  12. Cholesteryl ester transfer between lipoproteins does not require a ternary tunnel complex with CETP.

    PubMed

    Lauer, Matthias E; Graff-Meyer, Alexandra; Rufer, Arne C; Maugeais, Cyrille; von der Mark, Elisabeth; Matile, Hugues; D'Arcy, Brigitte; Magg, Christine; Ringler, Philippe; Müller, Shirley A; Scherer, Sebastian; Dernick, Gregor; Thoma, Ralf; Hennig, Michael; Niesor, Eric J; Stahlberg, Henning

    2016-05-01

    The cholesteryl ester transfer protein (CETP) enables the transfer of cholesteryl ester (CE) from high-density lipoproteins (HDL) to low-density lipoproteins (LDL) in the plasma compartment. CETP inhibition raises plasma levels of HDL cholesterol; a ternary tunnel complex with CETP bridging HDL and LDL was suggested as a mechanism. Here, we test whether the inhibition of CETP tunnel complex formation is a promising approach to suppress CE transfer from HDL to LDL, for potential treatment of cardio-vascular disease (CVD). Three monoclonal antibodies against different epitopes of CETP are assayed for their potential to interfere with CE transfer between HDL and/or LDL. Surprisingly, antibodies that target the tips of the elongated CETP molecule, interaction sites sterically required to form the suggested transfer complexes, do not interfere with CETP activity, but an antibody binding to the central region does. We show that CETP interacts with HDL, but not with LDL. Our findings demonstrate that a ternary tunnel complex is not the mechanistic prerequisite to transfer CE among lipoproteins. PMID:26876146

  13. Does thermodynamics require a new expansion after the ``big crunch'' of our cosmos?

    NASA Astrophysics Data System (ADS)

    Recami, Erasmo; Zanchin, Vilson Tonin

    1986-09-01

    Recently, a unified geometrical approach to gravitational and strong interactions was proposed, based on the methods of general relativity. According to it, hadrons can be regarded as ``black-hole type'' solutions of new field equations describing two tensorial metric fields (the ordinary gravitational, and the ``strong'' one). By extending the Bekenstein-Hawking thermodynamics to those ``strong black holes'' (SBH), we show that (i) SBH thermodynamics seems to require a new expansion of our cosmos after its ``Big Crunch''. (This thermodynamical indication being rather unique, up to now, in showing that a recontraction of our cosmos has to be followed by a new ``creation'') (ii) a collapsing star with masses approximately in the range 3-5 solar masses, once reaching the neutron-star density, could re-explode tending to form a (radiating) object with a diameter of the order of 1 light-day: thus failing to create a gravitational black hole.

  14. Does thermodynamics require our cosmos to undergo a series of contraction/expansion cycles?

    NASA Astrophysics Data System (ADS)

    Recami, E.; Martinez, J. M.; Zanchin, V. T.

    A unified geometrical approach to strong and gravitational interactions has been recently proposed, based on the classical methods of general relativity. According to it, hadrons can be regarded as "black-hole type" solutions of new field equations describing two tensorial metric-fields (the ordinary gravitational field, and the "strong" one). In this paper, the authors seize the opportunity for an improved exposition of some elements of the theory relevant to our present scope, and they extend the Bekenstein-Hawking thermodynamics to the "strong black holes" (SBH). They show (1) that SBH thermodynamics seems to require a new expansion of our cosmos after its "big crunch"; (2) that a collapsing star with a mass 3 - 5 M_sun;, once reached the neutron-star density, could re-explode tending to form a (radiating) object with a diameter of the order of 1 light-day.

  15. Effective Date of Requirement for Premarket Approval for Surgical Mesh for Transvaginal Pelvic Organ Prolapse Repair. Final order.

    PubMed

    2016-01-01

    The Food and Drug Administration (FDA or the Agency) is issuing a final order to require the filing of a premarket approval application (PMA) or notice of completion of a product development protocol (PDP) for surgical mesh for transvaginal pelvic organ prolapse (POP) repair. PMID:26742183

  16. 48 CFR 552.212-72 - Contract Terms and Conditions Required To Implement Statutes or Executive Orders Applicable to...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract Terms and... ADMINISTRATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 552.212-72 Contract Terms and Conditions Required To Implement Statutes or Executive Orders Applicable...

  17. 34 CFR 222.64 - What other requirements must a local educational agency meet in order to be eligible for...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... meet in order to be eligible for financial assistance under section 8003(f)(2)(B)? 222.64 Section 222.64 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND... Local Educational Agencies Under Section 8003(f) of the Act § 222.64 What other requirements must...

  18. 49 CFR 511.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... other information and granting immunity. 511.39 Section 511.39 Transportation Other Regulations Relating... testify or provide other information and granting immunity. (a) A party who desires the issuance of an order requiring a witness to testify or provide other information upon being granted immunity...

  19. 16 CFR 1025.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... provide other information and granting immunity. 1025.39 Section 1025.39 Commercial Practices CONSUMER... Process § 1025.39 Orders requiring witnesses to testify or provide other information and granting immunity... witness or deponent to testify or provide other information upon being granted immunity from...

  20. 49 CFR 511.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... other information and granting immunity. 511.39 Section 511.39 Transportation Other Regulations Relating... testify or provide other information and granting immunity. (a) A party who desires the issuance of an order requiring a witness to testify or provide other information upon being granted immunity...

  1. 16 CFR 3.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... provide other information and granting immunity. 3.39 Section 3.39 Commercial Practices FEDERAL TRADE... granting immunity. (a) Where Commission complaint counsel desire the issuance of an order requiring a witness or deponent to testify or provide other information and granting immunity under 18 U.S.C....

  2. 16 CFR 3.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... provide other information and granting immunity. 3.39 Section 3.39 Commercial Practices FEDERAL TRADE... granting immunity. (a) Where Commission complaint counsel desire the issuance of an order requiring a witness or deponent to testify or provide other information and granting immunity under 18 U.S.C....

  3. 16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity...

  4. 16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity...

  5. 16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity...

  6. 16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity...

  7. 16 CFR 1025.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... provide other information and granting immunity. 1025.39 Section 1025.39 Commercial Practices CONSUMER... Process § 1025.39 Orders requiring witnesses to testify or provide other information and granting immunity... witness or deponent to testify or provide other information upon being granted immunity from...

  8. 12 CFR 1080.12 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... provide other information and granting immunity. 1080.12 Section 1080.12 Banks and Banking BUREAU OF... testify or provide other information and granting immunity. (a) The Assistant Director of the Division of... issuance of an order requiring a witness to testify or provide other information granting immunity under...

  9. 16 CFR 1025.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... provide other information and granting immunity. 1025.39 Section 1025.39 Commercial Practices CONSUMER... Process § 1025.39 Orders requiring witnesses to testify or provide other information and granting immunity... witness or deponent to testify or provide other information upon being granted immunity from...

  10. 16 CFR 3.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... provide other information and granting immunity. 3.39 Section 3.39 Commercial Practices FEDERAL TRADE... granting immunity. (a) Where Commission complaint counsel desire the issuance of an order requiring a witness or deponent to testify or provide other information and granting immunity under 18 U.S.C....

  11. 16 CFR 3.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... provide other information and granting immunity. 3.39 Section 3.39 Commercial Practices FEDERAL TRADE... granting immunity. (a) Where Commission complaint counsel desire the issuance of an order requiring a witness or deponent to testify or provide other information and granting immunity under 18 U.S.C....

  12. 49 CFR 511.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... other information and granting immunity. 511.39 Section 511.39 Transportation Other Regulations Relating... testify or provide other information and granting immunity. (a) A party who desires the issuance of an order requiring a witness to testify or provide other information upon being granted immunity...

  13. 49 CFR 511.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... other information and granting immunity. 511.39 Section 511.39 Transportation Other Regulations Relating... testify or provide other information and granting immunity. (a) A party who desires the issuance of an order requiring a witness to testify or provide other information upon being granted immunity...

  14. 16 CFR 1025.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... provide other information and granting immunity. 1025.39 Section 1025.39 Commercial Practices CONSUMER... Process § 1025.39 Orders requiring witnesses to testify or provide other information and granting immunity... witness or deponent to testify or provide other information upon being granted immunity from...

  15. 16 CFR 1025.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... provide other information and granting immunity. 1025.39 Section 1025.39 Commercial Practices CONSUMER... Process § 1025.39 Orders requiring witnesses to testify or provide other information and granting immunity... witness or deponent to testify or provide other information upon being granted immunity from...

  16. 16 CFR 3.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... provide other information and granting immunity. 3.39 Section 3.39 Commercial Practices FEDERAL TRADE... granting immunity. (a) Where Commission complaint counsel desire the issuance of an order requiring a witness or deponent to testify or provide other information and granting immunity under 18 U.S.C....

  17. 16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity...

  18. 49 CFR 511.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... other information and granting immunity. 511.39 Section 511.39 Transportation Other Regulations Relating... testify or provide other information and granting immunity. (a) A party who desires the issuance of an order requiring a witness to testify or provide other information upon being granted immunity...

  19. Functional requirements of AID's higher order structures and their interaction with RNA-binding proteins.

    PubMed

    Mondal, Samiran; Begum, Nasim A; Hu, Wenjun; Honjo, Tasuku

    2016-03-15

    Activation-induced cytidine deaminase (AID) is essential for the somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes. Although both the N and C termini of AID have unique functions in DNA cleavage and recombination, respectively, during SHM and CSR, their molecular mechanisms are poorly understood. Using a bimolecular fluorescence complementation (BiFC) assay combined with glycerol gradient fractionation, we revealed that the AID C terminus is required for a stable dimer formation. Furthermore, AID monomers and dimers form complexes with distinct heterogeneous nuclear ribonucleoproteins (hnRNPs). AID monomers associate with DNA cleavage cofactor hnRNP K whereas AID dimers associate with recombination cofactors hnRNP L, hnRNP U, and Serpine mRNA-binding protein 1. All of these AID/ribonucleoprotein associations are RNA-dependent. We propose that AID's structure-specific cofactor complex formations differentially contribute to its DNA-cleavage and recombination functions. PMID:26929374

  20. Aspergillus nidulans Ambient pH Signaling Does Not Require Endocytosis

    PubMed Central

    Lucena-Agell, Daniel; Galindo, Antonio; Arst, Herbert N.

    2015-01-01

    Aspergillus nidulans (Pal) ambient pH signaling takes place in cortical structures containing components of the ESCRT pathway, which are hijacked by the alkaline pH-activated, ubiquitin-modified version of the arrestin-like protein PalF and taken to the plasma membrane. There, ESCRTs scaffold the assembly of dedicated Pal proteins acting downstream. The molecular details of this pathway, which results in the two-step proteolytic processing of the transcription factor PacC, have received considerable attention due to the key role that it plays in fungal pathogenicity. While current evidence strongly indicates that the pH signaling role of ESCRT complexes is limited to plasma membrane-associated structures where PacC proteolysis would take place, the localization of the PalB protease, which almost certainly catalyzes the first and only pH-regulated proteolytic step, had not been investigated. In view of ESCRT participation, this formally leaves open the possibility that PalB activation requires endocytic internalization. As endocytosis is essential for hyphal growth, nonlethal endocytic mutations are predicted to cause an incomplete block. We used a SynA internalization assay to measure the extent to which any given mutation prevents endocytosis. We show that none of the tested mutations impairing endocytosis to different degrees, including slaB1, conditionally causing a complete block, have any effect on the activation of the pathway. We further show that PalB, like PalA and PalC, localizes to cortical structures in an alkaline pH-dependent manner. Therefore, signaling through the Pal pathway does not involve endocytosis. PMID:25841020

  1. Does Every Necrotizing Granulomatous Inflammation Identified by NSCLC Resection Material Require Treatment?

    PubMed Central

    Yakar, Fatih; Yakar, Aysun; Büyükpınarbaşılı, Nur; Erelel, Mustafa

    2016-01-01

    Background Lung cancer and tuberculosis (TB) are two major public health problems. They can coexist or appear sequentially. In patients with TB, lung cancer risk is increased. However, vice versa is not crystal clear. In this study, we aimed to determine the development of TB in patients with resectabled non-small cell lung cancer (NSCLC) in a 2-year postoperative follow-up period. Material/Methods We conducted a retrospective cohort study at three university hospitals. Patients who had NSCLC surgery between 2009 and 2013 were included and patient records were reviewed for the presence of necrotizing granulomatous inflammation (NGI) in resected specimens. Demographic properties, tumor type, stage, location, type of surgery, tuberculosis history, and thorax CT findings were recorded. We searched for the development of tuberculosis within a 2-year period after surgery. Results A total of 1027 patient cases were reviewed, of which 48 patients had NGI. The median age was 63 years. The most common type of cancer was squamous carcinoma; and lobectomy was the preferred operation (70.8%). Cancer involvement most commonly included the right lung (61.8%) and upper lobes (47,9%). Only 11 patients had anti-TB treatment postoperatively, which was based on radiological findings. Prior tuberculosis or anti-TB history, type, stage or localization of cancer, and adjuvant/neoadjuvant therapy were not found to be related to TB treatment. None of the study population had TB during the two-year follow-up period. Treatment decisions appeared mostly related to physician experience. There was no difference in the risk of developing TB between patients with or without treatment. This finding may change the management of our patients. Conclusions Every NGI discovered in NSCLC resected material does not always require anti-TB treatment. PMID:27064420

  2. Students' Self-Assessment in Chemistry Examinations Requiring Higher- and Lower-Order Cognitive Skills

    NASA Astrophysics Data System (ADS)

    Zoller*, Uri; Fastow, Michal; Lubezky, Aviva; Tsaparlis, Georgios

    1999-01-01

    The development of students' higher-order cognitive skills (HOCS) in the context of both chemistry and the complex interrelationships of science, technology, environment, and society is widely accepted as one of the most important goals of chemical education. Consequently, the translation of this goal into teaching, assessment, and learning strategies is a central issue in chemistry teaching. Students' self-assessment in chemistry examinations is a HOCS-promoting strategy. We evaluated the differences between students' self-assessment and their professors' assessment on midterm exams in introductory college courses in Israel and Greece, together with the students' appraisal of their capability for self- and peer-assessment. We found that (i) there were small (not significant) and large (significant) differences between students' self-grading and their professors' grading on LOCS and HOCS exam questions, respectively; (ii) students' estimates of their grades were higher than those of their professors, particularly for HOCS questions; and (iii) students believed that they were capable of self- and peer-assessment and were confident in making these assessments. Our results suggest that (i) students' self-assessment of LOCS-type exams can be successfully implemented immediately, whereas (ii) implementation of self-assessment for HOCS-type exam questions should be gradual, following appropriate preparation to close the gap between the future HOCS and contemporary dominant LOCS orientations in chemistry teaching and learning.

  3. MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration.

    PubMed

    Aranda, Juan F; Reglero-Real, Natalia; Kremer, Leonor; Marcos-Ramiro, Beatriz; Ruiz-Sáenz, Ana; Calvo, María; Enrich, Carlos; Correas, Isabel; Millán, Jaime; Alonso, Miguel A

    2011-04-15

    Membrane organization into condensed domains or rafts provides molecular platforms for selective recruitment of proteins. Cell migration is a general process that requires spatiotemporal targeting of Rac1 to membrane rafts. The protein machinery responsible for making rafts competent to recruit Rac1 remains elusive. Some members of the MAL family of proteins are involved in specialized processes dependent on this type of membrane. Because condensed membrane domains are a general feature of the plasma membrane of all mammalian cells, we hypothesized that MAL family members with ubiquitous expression and plasma membrane distribution could be involved in the organization of membranes for cell migration. We show that myeloid-associated differentiation marker (MYADM), a protein with unique features within the MAL family, colocalizes with Rac1 in membrane protrusions at the cell surface and distributes in condensed membranes. MYADM knockdown (KD) cells had altered membrane condensation and showed deficient incorporation of Rac1 to membrane raft fractions and, similar to Rac1 KD cells, exhibited reduced cell spreading and migration. Results of rescue-of-function experiments by expression of MYADM or active Rac1L61 in cells knocked down for Rac1 or MYADM, respectively, are consistent with the idea that MYADM and Rac1 act on parallel pathways that lead to similar functional outcomes. PMID:21325632

  4. Orderly progression through S-phase requires dynamic ubiquitylation and deubiquitylation of PCNA.

    PubMed

    Álvarez, Vanesa; Viñas, Laura; Gallego-Sánchez, Alfonso; Andrés, Sonia; Sacristán, María P; Bueno, Avelino

    2016-01-01

    Proliferating-cell nuclear antigen (PCNA) is a DNA sliding clamp with an essential function in DNA replication and a key role in tolerance to DNA damage by ensuring the bypass of lesions. In eukaryotes, DNA damage tolerance is regulated by ubiquitylation of lysine 164 of PCNA through a well-known control mechanism; however, the regulation of PCNA deubiquitylation remains poorly understood. Our work is a systematic and functional study on PCNA deubiquitylating enzymes (DUBs) in Schizosaccharomyces pombe. Our study reveals that the deubiquitylation of PCNA in fission yeast cells is a complex process that requires several ubiquitin proteases dedicated to the deubiquitylation of a specific subnuclear fraction of mono- and di-ubiquitylated PCNA or a particular type of poly-ubiquitylated PCNA and that there is little redundancy among these enzymes. To understand how DUB activity regulates the oscillatory pattern of ubiquitylated PCNA in fission yeast, we assembled multiple DUB mutants and found that a quadruple mutation of ubp2(+), ubp12(+), ubp15(+), and ubp16(+) leads to the stable accumulation of mono-, di-, and poly-ubiquitylated forms of PCNA, increases S-phase duration, and sensitizes cells to DNA damage. Our data suggest that the dynamic ubiquitylation and deubiquitylation of PCNA occurs during S-phase to ensure processive DNA replication. PMID:27151298

  5. Orderly progression through S-phase requires dynamic ubiquitylation and deubiquitylation of PCNA

    PubMed Central

    Álvarez, Vanesa; Viñas, Laura; Gallego-Sánchez, Alfonso; Andrés, Sonia; Sacristán, María P.; Bueno, Avelino

    2016-01-01

    Proliferating-cell nuclear antigen (PCNA) is a DNA sliding clamp with an essential function in DNA replication and a key role in tolerance to DNA damage by ensuring the bypass of lesions. In eukaryotes, DNA damage tolerance is regulated by ubiquitylation of lysine 164 of PCNA through a well-known control mechanism; however, the regulation of PCNA deubiquitylation remains poorly understood. Our work is a systematic and functional study on PCNA deubiquitylating enzymes (DUBs) in Schizosaccharomyces pombe. Our study reveals that the deubiquitylation of PCNA in fission yeast cells is a complex process that requires several ubiquitin proteases dedicated to the deubiquitylation of a specific subnuclear fraction of mono- and di-ubiquitylated PCNA or a particular type of poly-ubiquitylated PCNA and that there is little redundancy among these enzymes. To understand how DUB activity regulates the oscillatory pattern of ubiquitylated PCNA in fission yeast, we assembled multiple DUB mutants and found that a quadruple mutation of ubp2+, ubp12+, ubp15+, and ubp16+ leads to the stable accumulation of mono-, di-, and poly-ubiquitylated forms of PCNA, increases S-phase duration, and sensitizes cells to DNA damage. Our data suggest that the dynamic ubiquitylation and deubiquitylation of PCNA occurs during S-phase to ensure processive DNA replication. PMID:27151298

  6. 34 CFR 461.44 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false How does a State request a waiver of the maintenance of effort requirement? 461.44 Section 461.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT...

  7. 34 CFR 461.44 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false How does a State request a waiver of the maintenance of effort requirement? 461.44 Section 461.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT...

  8. 40 CFR 60.2565 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false How does the model rule relate to the required elements of my State plan? 60.2565 Section 60.2565 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emissions Guidelines and Compliance...

  9. 40 CFR 60.1575 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false How does the model rule relate to the required elements of my State plan? 60.1575 Section 60.1575 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emission Guidelines and Compliance Times...

  10. 40 CFR 60.2565 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false How does the model rule relate to the required elements of my State plan? 60.2565 Section 60.2565 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emissions Guidelines and Compliance...

  11. 40 CFR 60.5075 - How does the model rule relate to the required elements of my state plan?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false How does the model rule relate to the required elements of my state plan? 60.5075 Section 60.5075 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emission Guidelines and Compliance Times...

  12. 40 CFR 60.2997 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false How does the model rule relate to the required elements of my State plan? 60.2997 Section 60.2997 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emission Guidelines and Compliance Times...

  13. 40 CFR 60.2997 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false How does the model rule relate to the required elements of my State plan? 60.2997 Section 60.2997 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emission Guidelines and Compliance Times...

  14. 14 CFR 382.97 - To which aircraft does the requirement to provide boarding and deplaning assistance through the...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false To which aircraft does the requirement to... Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Boarding, Deplaning, and...

  15. 14 CFR 382.97 - To which aircraft does the requirement to provide boarding and deplaning assistance through the...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false To which aircraft does the requirement to... Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Boarding, Deplaning, and...

  16. 14 CFR 382.97 - To which aircraft does the requirement to provide boarding and deplaning assistance through the...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false To which aircraft does the requirement to... Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Boarding, Deplaning, and...

  17. 14 CFR 382.97 - To which aircraft does the requirement to provide boarding and deplaning assistance through the...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false To which aircraft does the requirement to provide boarding and deplaning assistance through the use of lifts apply? 382.97 Section 382.97 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS...

  18. 14 CFR 382.97 - To which aircraft does the requirement to provide boarding and deplaning assistance through the...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false To which aircraft does the requirement to... Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Boarding, Deplaning, and...

  19. 40 CFR 60.1575 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false How does the model rule relate to the required elements of my State plan? 60.1575 Section 60.1575 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emission Guidelines and Compliance Times...

  20. 40 CFR 141.570 - What does subpart T require that my system report to the State?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false What does subpart T require that my system report to the State? 141.570 Section 141.570 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and Disinfection-Systems Serving...

  1. 40 CFR 141.570 - What does subpart T require that my system report to the State?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false What does subpart T require that my system report to the State? 141.570 Section 141.570 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and Disinfection-Systems Serving...

  2. 13 CFR 124.601 - What reports does SBA require concerning parties who assist Participants in obtaining federal...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Credit and Assistance SMALL BUSINESS ADMINISTRATION 8(a) BUSINESS DEVELOPMENT/SMALL DISADVANTAGED BUSINESS STATUS DETERMINATIONS 8(a) Business Development Miscellaneous Reporting Requirements § 124.601... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false What reports does SBA...

  3. 13 CFR 124.601 - What reports does SBA require concerning parties who assist Participants in obtaining federal...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Credit and Assistance SMALL BUSINESS ADMINISTRATION 8(a) BUSINESS DEVELOPMENT/SMALL DISADVANTAGED BUSINESS STATUS DETERMINATIONS 8(a) Business Development Miscellaneous Reporting Requirements § 124.601... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What reports does SBA...

  4. 13 CFR 124.601 - What reports does SBA require concerning parties who assist Participants in obtaining federal...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Credit and Assistance SMALL BUSINESS ADMINISTRATION 8(a) BUSINESS DEVELOPMENT/SMALL DISADVANTAGED BUSINESS STATUS DETERMINATIONS 8(a) Business Development Miscellaneous Reporting Requirements § 124.601... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false What reports does SBA...

  5. 13 CFR 124.601 - What reports does SBA require concerning parties who assist Participants in obtaining federal...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Credit and Assistance SMALL BUSINESS ADMINISTRATION 8(a) BUSINESS DEVELOPMENT/SMALL DISADVANTAGED BUSINESS STATUS DETERMINATIONS 8(a) Business Development Miscellaneous Reporting Requirements § 124.601... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false What reports does SBA...

  6. 13 CFR 124.601 - What reports does SBA require concerning parties who assist Participants in obtaining federal...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Credit and Assistance SMALL BUSINESS ADMINISTRATION 8(a) BUSINESS DEVELOPMENT/SMALL DISADVANTAGED BUSINESS STATUS DETERMINATIONS 8(a) Business Development Miscellaneous Reporting Requirements § 124.601... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false What reports does SBA...

  7. The Knotted Sky II: does BICEP2 require a nontrivial primordial power spectrum?

    SciTech Connect

    Abazajian, Kevork N.; Aslanyan, Grigor; Easther, Richard; Price, Layne C. E-mail: g.aslanyan@auckland.ac.nz E-mail: lpri691@aucklanduni.ac.nz

    2014-08-01

    An inflationary gravitational wave background consistent with BICEP2 is difficult to reconcile with a simple power-law spectrum of primordial scalar perturbations. Tensor modes contribute to the temperature anisotropies at multipoles with l∼< 100, and this effect — together with a prior on the form of the scalar perturbations — was the source of previous bounds on the tensor-to-scalar ratio. We compute Bayesian evidence for combined fits to BICEP2 and Planck for three nontrivial primordial spectra: a) a running spectral index, b) a cutoff at fixed wavenumber, and c) a spectrum described by a linear spline with a single internal knot. We find no evidence for a cutoff, weak evidence for a running index, and significant evidence for a ''broken'' spectrum. Taken at face-value, the BICEP2 results require two new inflationary parameters in order to describe both the broken scale invariance in the perturbation spectrum and the observed tensor-to-scalar ratio. Alternatively, this tension may be resolved by additional data and more detailed analyses.

  8. A DOE contractor`s perspective of environmental monitoring requirements at a low-level waste facility

    SciTech Connect

    Ferns, T.W.

    1989-11-01

    Environmental monitoring at a low-level waste disposal facility (LLWDF) should, (1) demonstrate compliance with environmental laws; (2) detect any spatial or temporal environmental changes; and (3) provide information on the potential or actual exposure of humans and/or the environment to disposed waste and/or waste by-products. Under the DOE Order system the LLWDF site manager has more freedom of implementation for a monitoring program than either the semi-prescriptive NRC, or the prescriptive EPA hazardous waste programs. This paper will attempt to compare and contrast environmental monitoring under the different systems (DOE, NRC, and EPA), and determine if the DOE might benefit from a more prescriptive system.

  9. The Clean Air Act Amendments of 1990: Hazardous Air Pollutant Requirements and the DOE Clean Coal Technology Program

    SciTech Connect

    Moskowitz, P.D.; DePhillips, M.; Fthenakis, V.M. ); Hemenway, A. )

    1991-01-01

    The purpose of the US Department of Energy -- Office of Fossil Energy (DOE FE) Clean Coal Technology Program (CCTP) is to provide the US energy marketplace with advanced, efficient, and environmentally sound coal-based technologies. The design, construction, and operation of Clean Coal Technology Demonstration Projects (CCTDP) will generate data needed to make informed, confident decisions on the commercial readiness of these technologies. These data also will provide information needed to ensure a proactive response by DOE and its industrial partners to the establishment of new regulations or a reactive response to existing regulations promulgated by the US Environmental Protection Agency (EPA). The objectives of this paper are to: (1) Present a preliminary examination of the potential implications of the Clean Air Act Amendments (CAAA) -- Title 3 Hazardous Air Pollutant requirements to the commercialization of CCTDP; and (2) help define options available to DOE and its industrial partners to respond to this newly enacted Legislation.

  10. The Clean Air Act Amendments of 1990: Hazardous Air Pollutant Requirements and the DOE Clean Coal Technology Program

    SciTech Connect

    Moskowitz, P.D.; DePhillips, M.; Fthenakis, V.M.; Hemenway, A.

    1991-12-31

    The purpose of the US Department of Energy -- Office of Fossil Energy (DOE FE) Clean Coal Technology Program (CCTP) is to provide the US energy marketplace with advanced, efficient, and environmentally sound coal-based technologies. The design, construction, and operation of Clean Coal Technology Demonstration Projects (CCTDP) will generate data needed to make informed, confident decisions on the commercial readiness of these technologies. These data also will provide information needed to ensure a proactive response by DOE and its industrial partners to the establishment of new regulations or a reactive response to existing regulations promulgated by the US Environmental Protection Agency (EPA). The objectives of this paper are to: (1) Present a preliminary examination of the potential implications of the Clean Air Act Amendments (CAAA) -- Title 3 Hazardous Air Pollutant requirements to the commercialization of CCTDP; and (2) help define options available to DOE and its industrial partners to respond to this newly enacted Legislation.

  11. 41 CFR 102-3.185 - What does this subpart require agencies to do?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... National Academy of Sciences or the National Academy of Public Administration? § 102-3.185 What does this... recommendation provided to an agency by the National Academy of Sciences (NAS) or the National Academy of Public Administration (NAPA) under an agreement between the agency and an academy, if such advice or recommendation......

  12. 41 CFR 102-3.185 - What does this subpart require agencies to do?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... National Academy of Sciences or the National Academy of Public Administration? § 102-3.185 What does this... recommendation provided to an agency by the National Academy of Sciences (NAS) or the National Academy of Public Administration (NAPA) under an agreement between the agency and an academy, if such advice or recommendation......

  13. 43 CFR 3602.14 - What kind of financial security does BLM require?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS...? (a) For contracts of $2,000 or more, BLM will require a performance bond of an amount sufficient to... post a performance bond. (b) BLM may require a performance bond for contracts of less than $2,000....

  14. 1994 Annual report on waste generation and waste minimization progress as required by DOE Order 5400.1, Hanford Site

    SciTech Connect

    1995-09-01

    Many Waste Minimization/Pollution Prevention successes at the Hanford Site occur every day without formal recognition. A few of the successful projects are: T-Plant helps facilities reuse equipment by offering decontamination services for items such as gas cylinders, trucks, and railcars, thus saving disposal and equipment replacement costs. Custodial Services reviewed its use of 168 hazardous cleaning products, and, through a variety of measures, replaced them with 38 safer substitutes, one for each task. Scrap steel contaminated with low level radioactivity from the interim stabilization of 107-K and 107-C was decontaminated and sold to a vendor for recycling. Site-wide programs include the following: the Pollution Prevention Opportunity Assessment (P2OA) program at the Hanford site was launched during 1994, including a training class, a guidance document, technical assistance, and goals; control over hazardous materials purchased was achieved by reviewing all purchase requisitions of a chemical nature; the Office Supply Reuse Program was established to redeploy unused or unwanted office supply items. In 1994, pollution prevention activities reduced approximately 274,000 kilograms of hazardous waste, 2,100 cubic meters of radioactive and mixed waste, 14,500,000 kilograms of sanitary waste, and 215,000 cubic meters off liquid waste and waste water. Pollution Prevention activities also saved almost $4.2 million in disposal, product, and labor costs. Overall waste generation increased in 1994 due to increased work and activity typical for a site with an environmental restoration mission. However, without any Waste Minimization/Pollution Prevention activities, solid radioactive waste generation at Hanford would have been 25% higher, solid hazardous waste generation would have been 30% higher, and solid sanitary waste generation would have been 60% higher.

  15. 1999 Annual Report on Waste Generation and Pollution Prevention Progress as Required by DOE Order 5400.1

    SciTech Connect

    SEGALL, P.

    2000-03-01

    Hanford's missions are to safely clean-up and manage the site's legacy wastes, and to develop and deploy science and technology. Through these missions Hanford will contribute to economic diversification of the region. Hanford's environmental management or clean-up mission is to protect the health and safety of the public, workers, and the environment; control hazardous materials; and utilize the assets (people, infrastructure, and site) for other missions. Hanford's science and technology mission is to develop and deploy science and technology in the service of the nation including stewardship of the Hanford Site. Pollution Prevention is a key to the success of these missions by reducing the amount of waste to be managed and identifying/implementing cost effective waste reduction projects. Hanford's original mission, the production of nuclear materials for the nation's defense programs, lasted more than 40 years, and like most manufacturing operations, Hanford's operations generated large quantities of waste and pollution. However, the by-products from Hanford operations pose unique problems like radiation hazards, vast volumes of contaminated water and soil, and many contaminated structures including reactors, chemical plants and evaporation ponds. The clean-up activity is an immense and challenging undertaking. Including characterization and decommissioning of 149 single shell storage tanks, treating 28 double shell tanks, safely disposing of over 2,100 metric tons of spent nuclear fuel stored on site, removing numerous structures, and dealing with significant solid waste, ground water, and land restoration issues.

  16. 1995 Annual report on waste generation and waste mainization progress as required by DOE order 5400.1, Hanford site

    SciTech Connect

    Betsch, M.D.

    1996-09-24

    While waste generation numbers are important, the true measure of success is waste minimized. Many Waste Minimization/Pollution Prevention (WMin/P2) successes at the Hanford Site occur every day without formal recognition as pollution prevention, as they have become part of a culture of best management practices. As an example, the success of the excess and reuse program, both informal and formal, documents the Wmin/P2 culture that exists in the pollution prevention representatives and employees at the facilities.

  17. 1997 annual report on waste generation and waste minimization progress as required by DOE Order 5400.1, Hanford Site

    SciTech Connect

    Segall, P.

    1998-04-13

    Hanford`s missions are to safely clean up and manage the site`s legacy wastes, and to develop and deploy science and technology. Through these missions Hanford will contribute to economic diversification of the region. Hanford`s environmental management or cleanup mission is to protect the health and safety of the public, workers, and the environment; control hazardous materials; and utilize the assets (people, infra structure, site) for other missions. Hanford`s science and technology mission is to develop and deploy science and technology in the service of the nation including stewardship of the Hanford Site. Pollution Prevention is a key to the success of these missions by reducing the amount of waste to be managed and identifying/implementing cost effective waste reduction projects. Hanford`s original mission, the production of nuclear materials for the nation`s defense programs, lasted more than 40 years, and like most manufacturing operations, Hanford`s operations generated large quantities of waste and pollution. However, the by-products from Hanford operations pose unique problems like radiation hazards, vast volumes of contaminated water and soil, and many contaminated structures including reactors, chemical plants and evaporation ponds. The cleanup activity is an immense and challenging undertaking, which includes characterization and decommissioning of 149 single shell storage tanks, treating 28 double shell tanks, safely disposing of over 2,100 metric tons of spent nuclear fuel stored on site, removing numerous structures, and dealing with significant solid waste, ground water, and land restoration issues.

  18. Preparation, review, and approval of implementation plans for nuclear safety requirements

    SciTech Connect

    Not Available

    1994-10-01

    This standard describes an acceptable method to prepare, review, and approve implementation plans for DOE Nuclear Safety requirements. DOE requirements are identified in DOE Rules, Orders, Notices, Immediate Action Directives, and Manuals.

  19. 40 CFR 763.122 - What does this subpart require me to do?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... standards in 29 CFR 1910.1001. (c) Repair, cleaning, or replacement of asbestos-containing clutch plates and...) Construction activities identified in 29 CFR 1926.1101(a), you must: (1) Comply with the OSHA standards in 29 CFR 1926.1101. (2) Submit notifications required for alternative control methods to the...

  20. 21 CFR 1271.45 - What requirements does this subpart contain?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Donor Eligibility § 1271.45 What... all donors of cells or tissue used in HCT/Ps, except as provided under § 1271.90. In the case of an embryo or of cells derived from an embryo, a donor-eligibility determination is required for both...

  1. 21 CFR 1271.45 - What requirements does this subpart contain?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Donor Eligibility § 1271.45 What... all donors of cells or tissue used in HCT/Ps, except as provided under § 1271.90. In the case of an embryo or of cells derived from an embryo, a donor-eligibility determination is required for both...

  2. 40 CFR 763.122 - What does this subpart require me to do?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... standards in 29 CFR 1910.1001. (c) Repair, cleaning, or replacement of asbestos-containing clutch plates and...) Construction activities identified in 29 CFR 1926.1101(a), you must: (1) Comply with the OSHA standards in 29 CFR 1926.1101. (2) Submit notifications required for alternative control methods to the...

  3. 40 CFR 763.122 - What does this subpart require me to do?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... standards in 29 CFR 1910.1001. (c) Repair, cleaning, or replacement of asbestos-containing clutch plates and...) Construction activities identified in 29 CFR 1926.1101(a), you must: (1) Comply with the OSHA standards in 29 CFR 1926.1101. (2) Submit notifications required for alternative control methods to the...

  4. 40 CFR 763.122 - What does this subpart require me to do?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... standards in 29 CFR 1910.1001. (c) Repair, cleaning, or replacement of asbestos-containing clutch plates and...) Construction activities identified in 29 CFR 1926.1101(a), you must: (1) Comply with the OSHA standards in 29 CFR 1926.1101. (2) Submit notifications required for alternative control methods to the...

  5. 40 CFR 763.122 - What does this subpart require me to do?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... standards in 29 CFR 1910.1001. (c) Repair, cleaning, or replacement of asbestos-containing clutch plates and...) Construction activities identified in 29 CFR 1926.1101(a), you must: (1) Comply with the OSHA standards in 29 CFR 1926.1101. (2) Submit notifications required for alternative control methods to the...

  6. 32 CFR 555.9 - Reporting requirements for work in support of DOE.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... RESERVATIONS AND NATIONAL CEMETERIES CORPS OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY RESEARCH AND... assigned the responsibility of Principal Laboratory for Energy R&D. (a) All executed agreements subordinate... 32 National Defense 3 2012-07-01 2009-07-01 true Reporting requirements for work in support of...

  7. 32 CFR 555.9 - Reporting requirements for work in support of DOE.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... MILITARY RESERVATIONS AND NATIONAL CEMETERIES CORPS OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY.... CERL has been assigned the responsibility of Principal Laboratory for Energy R&D. (a) All executed... 32 National Defense 3 2013-07-01 2013-07-01 false Reporting requirements for work in support...

  8. 32 CFR 555.9 - Reporting requirements for work in support of DOE.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... MILITARY RESERVATIONS AND NATIONAL CEMETERIES CORPS OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY.... CERL has been assigned the responsibility of Principal Laboratory for Energy R&D. (a) All executed... 32 National Defense 3 2014-07-01 2014-07-01 false Reporting requirements for work in support...

  9. Static magnetic therapy does not decrease pain or opioid requirements: a randomized double-blind trial.

    PubMed

    Cepeda, M Soledad; Carr, Daniel B; Sarquis, Tony; Miranda, Nelcy; Garcia, Ricardo J; Zarate, Camilo

    2007-02-01

    A growing multibillion dollar industry markets magnetic necklaces, bracelets, bands, insoles, back braces, mattresses, etc., for pain relief, although there is little evidence for their efficacy. We sought to evaluate the effect of magnetic therapy on pain intensity and opioid requirements in patients with postoperative pain. We designed a randomized, double-blind, controlled trial. One-hundred-sixty-five patients older than 12 yr of age were randomized to magnetic (n = 81) or sham therapy (n = 84) upon reporting moderate-to-severe pain in the postanesthesia care unit. Devices were placed over the surgical incision and left in place for 2 h. Patients rated their pain intensity on a 0-10 scale every 10 min and received incremental doses of morphine until pain intensity was < or =4 of 10. Pain intensity levels were similar in both groups. The magnet group had on average 0.04 U more pain intensity (95% confidence interval, -0.4 to 0.5) than the sham group. Opioid requirements also were similar in both groups. The active magnet group required 1.5 mg more morphine (95% confidence interval, -1.8 to 4.0) than the sham magnet group. Magnetic therapy lacks efficacy in controlling acute postoperative pain intensity levels or opioid requirements and should not be recommended for pain relief in this setting. PMID:17242082

  10. GONAD: A Novel CRISPR/Cas9 Genome Editing Method that Does Not Require Ex Vivo Handling of Embryos.

    PubMed

    Gurumurthy, Channabasavaiah B; Takahashi, Gou; Wada, Kenta; Miura, Hiromi; Sato, Masahiro; Ohtsuka, Masato

    2016-01-01

    Transgenic technologies used for creating a desired genomic change in animals involve three critical steps: isolation of fertilized eggs, microinjection of transgenic DNA into them and their subsequent transfer to recipient females. These ex vivo steps have been widely used for over 3 decades and they were also readily adapted for the latest genome editing technologies such as ZFNs, TALENs, and CRISPR/Cas9 systems. We recently developed a method called GONAD (Genome editing via Oviductal Nucleic Acids Delivery) that does not require all the three critical steps of transgenesis and therefore relieves the bottlenecks of widely used animal transgenic technologies. Here we provide protocols for the GONAD system. PMID:26724720

  11. Does It Help to Use Mathematically Superfluous Brackets When Teaching the Rules for the Order of Operations?

    ERIC Educational Resources Information Center

    Gunnarsson, Robert; Sönnerhed, Wang Wei; Hernell, Bernt

    2016-01-01

    The hypothesis that mathematically superfluous brackets can be useful when teaching the rules for the order of operations is challenged. The idea of the hypothesis is that with brackets it is possible to emphasize the order priority of one operation over another. An experiment was conducted where expressions with mixed operations were studied,…

  12. Natural phenomena hazards assessment criteria for DOE sites: DOE Standard DOE-STD-1023-95

    SciTech Connect

    Chen, J.C.; Lu, S.C.; Boissonnade, A.C.

    1995-03-24

    This paper summarizes hazard assessment criteria (DOE-STD-1023-95) for Natural Phenomena Hazards (NPH) at DOE sites. The DOE has established policy and requirements for NPH mitigation for DOE sites and facilities using a graded approach by DOE Order 5480.28. The graded approach is implemented by five performance categories established for structures, systems, and components (SSCs) at DOE facilities based on criteria provided by DOE-STD-1021-93. In applying the design/evaluation criteria of DOE-STD-1020-94 for DOE facilities subjected to one of the natural phenomena hazards, the establishment of design basis load levels consistent with the corresponding performance category is required. This standard provides general criteria as well as specific criteria for natural phenomena hazard assessments to ensure that adequate design basis load levels are established for design and/or evaluation of DOE facilities.

  13. Tracheotomy does not affect reducing sedation requirements of patients in intensive care – a retrospective study

    PubMed Central

    Veelo, Denise P; Dongelmans, Dave A; Binnekade, Jan M; Korevaar, Johanna C; Vroom, Margreeth B; Schultz, Marcus J

    2006-01-01

    Introduction Translaryngeal intubated and ventilated patients often need sedation to treat anxiety, agitation and/or pain. Current opinion is that tracheotomy reduces sedation requirements. We determined sedation needs before and after tracheotomy of intubated and mechanically ventilated patients. Methods We performed a retrospective analysis of the use of morphine, midazolam and propofol in patients before and after tracheotomy. Results Of 1,788 patients admitted to our intensive care unit during the study period, 129 (7%) were tracheotomized. After the exclusion of patients who received a tracheotomy before or at the day of admittance, 117 patients were left for analysis. The daily dose (DD; the amount of sedatives for each day) divided by the mean daily dose (MDD; the mean amount of sedatives per day for the study period) in the week before and the week after tracheotomy was 1.07 ± 0.93 DD/MDD versus 0.30 ± 0.65 for morphine, 0.84 ± 1.03 versus 0.11 ± 0.46 for midazolam, and 0.62 ± 1.05 versus 0.15 ± 0.45 for propofol (p < 0.01). However, when we focused on a shorter time interval (two days before and after tracheotomy), there were no differences in prescribed doses of morphine and midazolam. Studying the course in DD/MDD from seven days before the placement of tracheotomy, we found a significant decline in dosage. From day -7 to day -1, morphine dosage (DD/MDD) declined by 3.34 (95% confidence interval -1.61 to -6.24), midazolam dosage by 2.95 (-1.49 to -5.29) and propofol dosage by 1.05 (-0.41 to -2.01). After tracheotomy, no further decrease in DD/MDD was observed and the dosage remained stable for all sedatives. Patients in the non-surgical and acute surgical groups received higher dosages of midazolam than patients in the elective surgical group. Time until tracheotomy did not influence sedation requirements. In addition, there was no significant difference in sedation between different patient groups. Conclusion In our intensive care unit, sedation

  14. Influence of Rabbit Sire Genetic Origin, Season of Birth and Parity Order on Doe and Litter Performance in an Organic Production System

    PubMed Central

    Zotte, Antonella Dalle; Paci, Gisella

    2013-01-01

    The aim of this study was to compare both the performance of litters derived from two sire genetic origins (SGO), Vienna Blue (VB) and Burgundy Fawn (BF), along successive seasons of birth (SB; winter, spring, summer and autumn), and doe reproductive performance in an organic production system. A total of fifty-eight does consisting of a mixture of crosses of several medium-large size breeds at different parity order (P, 1 = nulliparous; 2 = primiparous; ≥3 = multiparous) and twelve males (6 VB and 6 BF) were housed indoors at environmental conditions that followed seasonality. An extensive reproductive rhythm was used and kits were weaned at 46±6 d of age. Doe reproductive performance and the data of 105 litters (55 from VB and 50 from BF SGO) were recorded throughout the SB. No statistically significant differences related to SGO effect were observed. As regards parity order, multiparous does showed higher live weights (LW) (p<0.05), total born (p<0.01), total born alive (p<0.05) per delivery, and litter weight of born alive (p<0.05), but lower milk output at 21st d than primiparous does (p<0.05). The extensive reproductive rhythm mainly increased litter performance at birth in multiparous does but was not sufficient to permit a complete recovery of body reserves lost during lactation. Autumn SB negatively affected doe LW variation between deliveries. The number of pups born and born alive per delivery (p<0.05) and litter size at 21 d of age and at weaning (p<0.01) were lower during hot SB. Due to the lower litter size of pups born in summer and autumn, their individual weight at 21st d of age and daily individual growth rate 0 to 21 d were higher than those of pups born in winter (p<0.001). Litter performance at 21st d of age and individual pup pre-weaning growth rate were poorer for those born in spring than in other seasons due to the harmful effects of increased environmental temperatures. SB affected most of the performance traits of does and young

  15. The Anorectic Effect of CNTF Does Not Require Action in Leptin-Responsive Neurons

    PubMed Central

    Stefater, M. A.; MacLennan, A. J.; Lee, N.; Patterson, C. M.; Haller, A.; Sorrell, J.; Myers, M.; Woods, S. C.

    2012-01-01

    Leptin resistance is a feature of obesity that poses a significant therapeutic challenge. Any treatment that is effective to reduce body weight in obese patients must overcome or circumvent leptin resistance, which promotes the maintenance of excess body fat in obese individuals. Ciliary neurotrophic factor (CNTF) is unique in its ability to reduce food intake and body weight in obese, leptin-resistant humans and rodents. Although attempts to use CNTF as an obesity therapy failed due to the development of neutralizing antibodies to the drug, efforts to understand mechanisms for CNTF's anorectic effects provide an opportunity to develop new drugs for leptin-resistant individuals. CNTF and leptin share several structural, anatomic, and signaling properties, but it is not understood whether or how the two cytokines might interact to affect energy balance. Here, we conditionally deleted the CNTF receptor (CNTFR) subunit, CNTFRα, in cells expressing leptin receptors. We found that CNTFR signaling in leptin-responsive neurons is not required for endogenous maintenance of energy balance and is not required for the anorectic response to exogenous administration of a CNTF agonist. These results indicate that despite anatomical overlap for CNTF and leptin action, CNTF appears to act within a distinct neuronal population to elicit its potent anorectic effect. PMID:22518062

  16. Laparoendoscopic single site surgery in pediatric urology: does it require specialized tools?

    PubMed Central

    Patel, Nishant; Santomauro, Michael; Marietti, Sarah; Chiang, George

    2016-01-01

    ABSTRACT Purpose: To describe our experience utilizing Laparoendoscopic single site (LESS) surgery in pediatric urology. Materials and Methods: Retrospective chart review was performed on LESS urologic procedures from November 2009 through March 2013. A total of 44 patients underwent 54 procedures including: nephrectomy (23), orchiopexy (14), varicocelectomy (9), orchiectomy (2), urachal cyst excision (3), and antegrade continence enema (3) (ACE). Results: Median patient age was 6.9 years old. Estimated blood loss (EBL), ranged from less than 5cc to 47cc for a bilateral nephrectomy. Operative time varied from 56 mins for varicocelectomy to a median of 360 minutes for a bilateral nephroureterectomy. Incision length ranged between 2 and 2.5cm. In our initial experience we used a commercial port. However, as we progressed, we were able to perform the majority of our procedures via adjacent fascial punctures for instrumentation at the single incision site. One patient did require conversion to an open procedure as a result of bleeding. Three complications were noted (6.8%), with two Clavien Grade 3b complications. Two patients required additional procedures at 1-year follow-up. Conclusions: The use of LESS applies to many pediatric urologic procedures, ideally for ablative procedures or simple reconstructive efforts. The use of adjacent fascial puncture sites for instrumentation can obviate the need for a commercial port or multiple trocars. PMID:27256182

  17. Does thermodynamics require a new expansion after the Big Crunch of our cosmos

    NASA Astrophysics Data System (ADS)

    Recami, E.; Tonin-Zanchin, V.

    Recently, a unifield geometrical approach to gravitational and strong interactions was proposed, based on the methods of General Relativity. According to it, hadrons can be regarded as black-hole type solutions of new field equations describing two tensorial metric-fields (the ordinary gravitational, and the strong one). By extending the Bekenstein-Hawking thermodynamics to those strong black-holes (SBH), it is shown: (1) that SBH thermodynamics seems to require a new expansion of our cosmos after its Big Crunch (this thermodynamical indication being rather unique, up to now, in showing that a recontraction of our cosmos has to be followed by a new creation); and (2) that a collapsing star with mass 2M sub(sun) less than = M less than 15M(sun), once overtaken the neutron-star phase, must re-explode reaching a diameter of at least a few light-days, thus failing to reach the black-hole state.

  18. Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2

    PubMed Central

    Schmidt, Paul J.; Fleming, Mark D.

    2012-01-01

    Hereditary hemochomatosis (HH) is caused by mutations in several genes, including HFE and transferrin receptor-2 (TFR2). Loss of either protein decreases expression of the iron regulatory hormone hepcidin by the liver, leading to inappropriately high iron uptake from the diet, and resulting in systemic iron overload. In tissue culture, overexpressed HFE and TFR2 physically interact. Hepatocellular overexpression of Hfe in vivo increases hepcidin expression, despite an associated decrease in Tfr2. On this basis, we hypothesized that Tfr2 would not be required for Hfe-dependent up-regulation of hepcidin. We show that hepatocellular overexpression of Hfe in Tfr2Y245X/Y245X mice leads to hepcidin induction eventuating in iron deficiency and a hypochromic, microcytic anemia. Furthermore, co-immunoprecipitation studies using liver lysates did not provide evidence for physical interaction between Hfe and Tfr2 in vivo. In conclusion, we demonstrate that Tfr2 is not essential for Hfe-mediated induction of hepcidin expression, supporting the possibility that TFR2 may regulate iron metabolism in an HFE-independent manner. PMID:22460705

  19. Isolation of a Hypomorphic skn-1 Allele That Does Not Require a Balancer for Maintenance

    PubMed Central

    Tang, Lanlan; Dodd, William; Choe, Keith

    2015-01-01

    In Caenorhabditis elegans, the transcription factor SKN-1 has emerged as a central coordinator of stress responses and longevity, increasing the need for genetic tools to study its regulation and function. However, current loss-of-function alleles cause fully penetrant maternal effect embryonic lethality, and must be maintained with genetic balancers that require careful monitoring and labor intensive strategies to obtain large populations. In this study, we identified a strong, but viable skn-1 hypomorphic allele skn-1(zj15) from a genetic screen for suppressors of wdr-23, a direct regulator of the transcription factor. skn-1(zj15) is a point mutation in an intron that causes mis-splicing of a fraction of mRNA, and strongly reduces wildtype mRNA levels of the two long skn-1a/c variants. The skn-1(zj15) allele reduces detoxification gene expression and stress resistance to levels comparable to skn-1 RNAi, but, unlike RNAi, it is not restricted from some tissues. We also show that skn-1(zj15) is epistatic to canonical upstream regulators, demonstrating its utility for genetic analysis of skn-1 function and regulation in cases where large numbers of worms are needed, a balancer is problematic, diet is varied, or RNAi cannot be used. PMID:26715089

  20. Hyphal growth in Candida albicans does not require induction of hyphal-specific gene expression

    PubMed Central

    Naseem, Shamoon; Araya, Esteban; Konopka, James B.

    2015-01-01

    Various stimuli, including N-acetylglucosamine (GlcNAc), induce the fungal pathogen Candida albicans to switch from budding to hyphal growth. Previous studies suggested that hyphal morphogenesis is stimulated by transcriptional induction of a set of genes that includes known virulence factors. To better understand hyphal development, we examined the role of GlcNAc metabolism using a triple mutant lacking the genes required to metabolize exogenous GlcNAc (hxk1Δ nag1Δ dac1Δ). Surprisingly, at low ambient pH (∼pH 4), GlcNAc stimulated this mutant to form hyphae without obvious induction of hyphal genes. This indicates that GlcNAc can stimulate a separate signal to induce hyphae that is independent of transcriptional responses. Of interest, GlcNAc could induce the triple mutant to express hyphal genes when the medium was buffered to a higher pH (>pH 5), which normally occurs after GlcNAc catabolism. Catabolism of GlcNAc raises the ambient pH rather than acidifying it, as occurs after dextrose catabolism. This synergy between alkalinization and GlcNAc to induce hyphal genes involves the Rim101 pH-sensing pathway; GlcNAc induced rim101Δ and dfg16Δ mutants to form hyphae, but hyphal gene expression was partially defective. These results demonstrate that hyphal morphogenesis and gene expression can be regulated independently, which likely contributes to pathogenesis at different host sites. PMID:25609092

  1. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family...

  2. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family...

  3. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family...

  4. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family...

  5. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family...

  6. 20 CFR 411.375 - Does a State VR agency continue to provide services under the requirements of the State plan...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Does a State VR agency continue to provide... Rehabilitation Agencies' Participation Participation in the Ticket to Work Program § 411.375 Does a State VR.... The State VR agency must continue to provide services under the requirements of the State...

  7. 42 CFR 83.10 - If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... under § 83.9, does this mean the class will be added to the Cohort? 83.10 Section 83.10 Public Health... for Adding Classes of Employees to the Cohort § 83.10 If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be added to the Cohort? Satisfying the...

  8. 42 CFR 83.10 - If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... under § 83.9, does this mean the class will be added to the Cohort? 83.10 Section 83.10 Public Health... for Adding Classes of Employees to the Cohort § 83.10 If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be added to the Cohort? Satisfying the...

  9. 42 CFR 83.10 - If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... under § 83.9, does this mean the class will be added to the Cohort? 83.10 Section 83.10 Public Health... for Adding Classes of Employees to the Cohort § 83.10 If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be added to the Cohort? Satisfying the...

  10. 42 CFR 83.10 - If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... under § 83.9, does this mean the class will be added to the Cohort? 83.10 Section 83.10 Public Health... for Adding Classes of Employees to the Cohort § 83.10 If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be added to the Cohort? Satisfying the...

  11. Summary of the Special Analysis of Savannah River Depleted Uranium Trioxide Demonstrating the Before and After Impacts on the DOE Order 435.1 Performance Objective and the Peak Dose

    SciTech Connect

    Shott, G.J.

    2011-01-15

    This report summarizes the special analysis (SA) of the Savannah River Depleted Uranium Trioxide waste stream (SVRSURANIUM03, Revision 1) demonstrating the before and after impacts of the waste stream to the DOE Order 435.1 performance objective at the disposal facility, and the peak dose. The Nevada Division of Environmental Protection (NDEP) requested this SA and asked the Nevada Site Office (NSO) to run the SA deterministically and assume that all the model conditions remain the same regardless of the length of time to the peak dose. Although the NDEP accepts that DOE Order 435.1 requires a compliance period of 1,000 years, it also requested to know what year, if any, the specific DOE performance objectives will be exceeded. Given the NDEP’s requested model conditions, the SA demonstrates the Rn-222 peak dose will occur in about 2 million years and will exceed the performance objective in about 6,000 years. The 0.25 mSv y-1 all-pathway performance objective was not exceeded for the resident scenario after reaching the 4 million year peak dose.

  12. Porcine epidemic diarrhea virus (PEDV) co-infection induced chlamydial persistence/stress does not require viral replication

    PubMed Central

    Schoborg, Robert V.; Borel, Nicole

    2014-01-01

    Chlamydiae may exist at the site of infection in an alternative replicative form, called the aberrant body (AB). ABs are produced during a viable but non-infectious developmental state termed “persistence” or “chlamydial stress.” As persistent/stressed chlamydiae: (i) may contribute to chronic inflammation observed in diseases like trachoma; and (ii) are more resistant to current anti-chlamydial drugs of choice, it is critical to better understand this developmental stage. We previously demonstrated that porcine epidemic diarrhea virus (PEDV) co-infection induced Chlamydia pecorum persistence/stress in culture. One critical characteristic of persistence/stress is that the chlamydiae remain viable and can reenter the normal developmental cycle when the stressor is removed. Thus, we hypothesized that PEDV-induced persistence would be reversible if viral replication was inhibited. Therefore, we performed time course experiments in which Vero cells were C. pecorum/PEDV infected in the presence of cycloheximide (CHX), which inhibits viral but not chlamydial protein synthesis. CHX-exposure inhibited PEDV replication, but did not inhibit induction of C. pecorum persistence at 24 h post-PEDV infection, as indicated by AB formation and reduced production of infectious EBs. Interestingly, production of infectious EBs resumed when CHX-exposed, co-infected cells were incubated 48–72 h post-PEDV co-infection. These data demonstrate that PEDV co-infection-induced chlamydial persistence/stress is reversible and suggest that this induction (i) does not require viral replication in host cells; and (ii) does not require de novo host or viral protein synthesis. These data also suggest that viral binding and/or entry may be required for this effect. Because the PEDV host cell receptor (CD13 or aminopeptidase N) stimulates cellular signaling pathways in the absence of PEDV infection, we suspect that PEDV co-infection might alter CD13 function and induce the chlamydiae to

  13. Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models.

    PubMed

    Chen, Su-Ren; Tang, J-X; Cheng, J-M; Hao, X-X; Wang, Y-Q; Wang, X-X; Liu, Y-X

    2016-01-01

    Wingless-related MMTV integration site (WNT) proteins and several other components of the WNT signalling pathway are expressed in the murine testes. However, mice mutant for WNT signalling effector β-catenin using different Cre drivers have phenotypes that are inconsistent with each other. The complexity and overlapping expression of WNT signalling cascades have prevented researchers from dissecting their function in spermatogenesis. Depletion of the Gpr177 gene (the mouse orthologue of Drosophila Wntless), which is required for the secretion of various WNTs, makes it possible to genetically dissect the overall effect of WNTs in testis development. In this study, the Gpr177 gene was conditionally depleted in germ cells (Gpr177(flox/flox), Mvh-Cre; Gpr177(flox/flox), Stra8-Cre) and Sertoli cells (Gpr177(flox/flox), Amh-Cre). No obvious defects in fertility and spermatogenesis were observed in these three Gpr177 conditional knockout (cKO) mice at 8 weeks. However, late-onset testicular atrophy and fertility decline in two germ cell-specific Gpr177 deletion mice were noted at 8 months. In contrast, we did not observe any abnormalities of spermatogenesis and fertility, even in 8-month-old Gpr177(flox/flox), Amh-Cre mice. Elevation of reactive oxygen species (ROS) was detected in Gpr177 cKO germ cells and Sertoli cells and exhibited an age-dependent manner. However, significant increase in the activity of Caspase 3 was only observed in germ cells from 8-month-old germ cell-specific Gpr177 knockout mice. In conclusion, GPR177 in Sertoli cells had no apparent influence on spermatogenesis, whereas loss of GPR177 in germ cells disrupted spermatogenesis in an age-dependent manner via elevating ROS levels and triggering germ cell apoptosis. PMID:27362799

  14. Curing of yeast [PSI+] prion by guanidine inactivation of Hsp104 does not require cell division.

    PubMed

    Wu, Yue-Xuan; Greene, Lois E; Masison, Daniel C; Eisenberg, Evan

    2005-09-01

    Propagation of the yeast prion [PSI+], a self-replicating aggregated form of Sup35p, requires Hsp104. One model to explain this phenomenon proposes that, in the absence of Hsp104, Sup35p aggregates enlarge but fail to replicate thus becoming diluted out as the yeast divide. To test this model, we used live imaging of Sup35p-GFP to follow the changes that occur in [PSI+] cells after the addition of guanidine to inactivate Hsp104. After guanidine addition there was initially an increase in aggregation of Sup35p-GFP; but then, before the yeast divided, the aggregates began to dissolve, and after approximately 6 h the Sup35-GFP looked identical to the Sup35-GFP in [psi+] cells. Although plating studies showed that the yeast were still [PSI+], this reduction in aggregation suggested that curing of [PSI+] by inactivation of Hsp104 might be independent of cell division. This was tested by measuring the rate of curing of [PSI+] cells in both dividing and nondividing cells. Cell division was inhibited by adding either alpha factor or farnesol. Remarkably, with both of these methods, we found that the rate of curing was not significantly affected by cell division. Thus, cell division is not a determining factor for curing [PSI+] by inactivating Hsp104 with guanidine. Rather, curing apparently occurs because Sup35-GFP polymers slowly depolymerize in the absence of Hsp104 activity. Hsp104 then counteracts this curing possibly by catalyzing formation of new polymers. PMID:16123122

  15. Does the Noun Phrase Accessibility Hierarchy Predict the Difficulty Order in the Acquisition of Japanese Relative Clauses?

    ERIC Educational Resources Information Center

    Ozeki, Hiromi; Shirai, Yasuhiro

    2007-01-01

    Although Keenan and Comrie's (1977) noun phrase accessibility hierarchy (NPAH) has been shown to predict the difficulty order of relative clauses (RCs) in SLA, most studies of the NPAH have been on European languages. This paper tests the prediction for Japanese. Study 1 analyzes RCs in an oral interview corpus from 90 learners of Japanese at four…

  16. A discussion of higher order software concepts as they apply to functional requirements and specifications. [space shuttles and guidance

    NASA Technical Reports Server (NTRS)

    Hamilton, M.

    1973-01-01

    The entry guidance software functional requirements (requirements design phase), its architectural requirements (specifications design phase), and the entry guidance software verified code are discussed. It was found that the proper integration of designs at both the requirements and specifications levels are of high priority consideration.

  17. Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity

    PubMed Central

    Lin, Tao; Gao, Lihui; Zhang, Chuhua; Odeh, Evelyn; Jacobs, Mary B.; Coutte, Loïc; Chaconas, George; Philipp, Mario T.; Norris, Steven J.

    2012-01-01

    The identification of genes important in the pathogenesis of Lyme disease Borrelia has been hampered by exceedingly low transformation rates in low-passage, infectious organisms. Using the infectious, moderately transformable B. burgdorferi derivative 5A18NP1 and signature-tagged versions of the Himar1 transposon vector pGKT, we have constructed a defined transposon library for the efficient genome-wide investigation of genes required for wild-type pathogenesis, in vitro growth, physiology, morphology, and plasmid replication. To facilitate analysis, the insertion sites of 4,479 transposon mutants were determined by sequencing. The transposon insertions were widely distributed across the entire B. burgdorferi genome, with an average of 2.68 unique insertion sites per kb DNA. The 10 linear plasmids and 9 circular plasmids had insertions in 33 to 100 percent of their predicted genes. In contrast, only 35% of genes in the 910 kb linear chromosome had incapacitating insertions; therefore, the remaining 601 chromosomal genes may represent essential gene candidates. In initial signature-tagged mutagenesis (STM) analyses, 434 mutants were examined at multiple tissue sites for infectivity in mice using a semi-quantitative, Luminex-based DNA detection method. Examples of genes found to be important in mouse infectivity included those involved in motility, chemotaxis, the phosphoenolpyruvate phosphotransferase system, and other transporters, as well as putative plasmid maintenance genes. Availability of this ordered STM library and a high-throughput screening method is expected to lead to efficient assessment of the roles of B. burgdorferi genes in the infectious cycle and pathogenesis of Lyme disease. PMID:23133514

  18. The Switch Regulating Transcription of the Escherichia coli Biotin Operon Does Not Require Extensive Protein-Protein Interactions

    PubMed Central

    Solbiati, José; Cronan, John E.

    2009-01-01

    Transcription of the Escherichia coli biotin (bio) operon is regulated by BirA, a protein that is not only the repressor that regulates bio operon expression by DNA binding but also the enzyme that covalently attaches biotin to its cognate acceptor proteins. Binding of BirA to the bio operator requires dimerization of the protein that is triggered by BirA-catalyzed synthesis of biotinoyl-adenylate (bio-AMP), the obligatory intermediate of the attachment reaction. The current model postulates that the unmodified acceptor protein binds the monomeric BirA:bio-AMP complex and thereby blocks assembly (dimerization) of the form of BirA that binds DNA. We report that expression of fusion proteins that carry synthetic biotin accepting peptide sequences was as effective as the natural acceptor protein in derepression of bio operon transcription. These peptide sequences have sequences that are remarkably dissimilar to that of the natural acceptor protein and thus our data argue that the regulatory switch does not require the extensive protein-protein interactions postulated in the current model. PMID:20142036

  19. 25 CFR 30.102 - Does the Act require the Secretary of the Interior to develop a definition of AYP for Bureau...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... develop a definition of AYP for Bureau-funded schools? 30.102 Section 30.102 Indians BUREAU OF INDIAN... § 30.102 Does the Act require the Secretary of the Interior to develop a definition of AYP for Bureau-funded schools? Yes, the Act requires the Secretary to develop a definition of AYP through...

  20. Downregulation of Mouse Hepatic CYP3A Protein by 3-Methylcholanthrene Does Not Require Cytochrome P450-Dependent Metabolism

    PubMed Central

    Lee, Chunja; Ding, Xinxin

    2013-01-01

    The aryl hydrocarbon receptor (AHR)–dependent induction of cytochromes P450 (P450) such as CYP1A1 by 3-methylcholanthrene (MC) and related polycyclic aromatic hydrocarbons is well characterized. We reported previously that MC treatment triggers a pronounced downregulation, particularly at the protein level, of mouse hepatic Cyp3a11, a counterpart of the key human drug-metabolizing enzyme CYP3A4. To determine whether this effect of MC requires hepatic microsomal P450 activity, we studied liver Cpr-null (LCN) mice with hepatocyte-specific conditional deletion of the NADPH-cytochrome P450 oxidoreductase gene. In vehicle-treated animals, basal levels of CYP3A11 mRNA and CYP3A protein immunoreactivity were elevated by approximately 9-fold in LCN mice compared with wild-type (WT) mice, whereas CYP3A catalytic activity was profoundly compromised in LCN mice. MC treatment caused suppression of CYP3A11 mRNA, CYP3A protein immunoreactivity, and CYP3A catalytic activity in WT mice, and the MC effects at the mRNA and protein levels were maintained in LCN mice. Flavin-containing monooxygenase-3 (Fmo3) induction by MC was suggested previously to occur via an AHR-dependent mechanism requiring conversion of the parent compound to DNA-damaging reactive metabolites; however, hepatic FMO3 mRNA levels were dramatically increased by MC in both WT and LCN mice. MC did not function as a mechanism-based inactivator of CYP3A enzymes in hepatic microsomes prepared from untreated WT mice, under conditions in which 1-aminobenzotriazole caused marked NADPH-dependent loss of total P450 content and CYP3A catalytic activity. These results indicate that MC downregulates mouse hepatic CYP3A protein via a pretranslational mechanism that does not require hepatic microsomal P450-dependent activity. PMID:23846873

  1. Guide to good practices for timely orders to operators

    SciTech Connect

    1998-12-01

    This Guide to Good Practices is written to enhance understanding of, and provide direction for, Timely Orders to Operators, Chapter XV of Department of Energy (DOE) Order 5480.19, Conduct of Operations Requirements for DOE Facilities. The practices in this guide should be considered when planning or reviewing Timely Orders to Operators programs. Contractors are advised to adopt procedures that meet the intent of DOE Order 5480.19. Timely Orders to Operators is an element of an effective Conduct of Operations program. The complexity and array of activities performed in DOE facilities dictate the necessity for timely orders to operators to promote safe and efficient operations.

  2. Quality assurance grading guidelines for research and development at DOE facilities

    SciTech Connect

    Powell, T.B.; Morris, R.N.

    1993-01-01

    The quality assurance (QA) requirements for the US Department of Energy (DOE) are established in DOE Order 5700.6C. This order is applicable for all DOE departmental elements, management, and maintenance and operating contractors and requires that documented Quality Assurance Programs (QAPs) are prepared at all levels; it has one attachment. The DOE Office of Energy Research (DOE-ER) has issued a standard to ensure implementation of the full intent of this order in the ER community.

  3. Delta Opioid activation of the Mitogen-activated protein kinase cascade does not require transphosphorylation of Receptor Tyrosine Kinases

    PubMed Central

    Kramer, H Kenneth; Onoprishvili, Irma; Andria, Matthew L; Hanna, Kayane; Sheinkman, Karina; Haddad, Lisa B; Simon, Eric J

    2002-01-01

    Background In this study, we investigated the mechanism(s) by which delta opioids induce their potent activation of extracellular signal-regulated protein kinases (ERKs) in different cell lines expressing the cloned δ-opioid receptor (δ-OR). While it has been known for some time that OR stimulation leads to the phosphorylation of both ERK isoforms, the exact progression of events has remained elusive. Results Our results indicate that the transphosphorylation of an endogenous epidermal growth factor receptor (EGFR) in the human embryonic kidney (HEK-293) cell line does not occur when co-expressed δ-ORs are stimulated by the δ-opioid agonist, D-Ser-Leu-enkephalin-Thr (DSLET). Moreover, neither pre-incubation of cultures with the selective EGFR antagonist, AG1478, nor down-regulation of the EGFR to a point where EGF could no longer activate ERKs had an inhibitory effect on ERK activation by DSLET. These results appear to rule out any structural or catalytic role for the EGFR in the δ-opioid-mediated MAPK cascade. To confirm these results, we used C6 glioma cells, a cell line devoid of the EGFR. In δ-OR-expressing C6 glioma cells, opioids produce a robust phosphorylation of ERK 1 and 2, whereas EGF has no stimulatory effect. Furthermore, antagonists to the RTKs that are endogenously expressed in C6 glioma cells (insulin receptor (IR) and platelet-derived growth factor receptor (PDGFR)) were unable to reduce opioid-mediated ERK activation. Conclusion Taken together, these data suggest that the transactivation of resident RTKs does not appear to be required for OR-mediated ERK phosphorylation and that the tyrosine-phosphorylated δ-OR, itself, is likely to act as its own signalling scaffold. PMID:11897012

  4. 34 CFR 636.11 - How does an applicant request a waiver of the planning consortium requirement?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false How does an applicant request a waiver of the planning... Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION URBAN COMMUNITY SERVICE PROGRAM How Does One Apply for an Award? § 636.11 How does an applicant request a waiver of the...

  5. 34 CFR 636.11 - How does an applicant request a waiver of the planning consortium requirement?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false How does an applicant request a waiver of the planning... Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION URBAN COMMUNITY SERVICE PROGRAM How Does One Apply for an Award? § 636.11 How does an applicant request a waiver of the...

  6. 34 CFR 636.11 - How does an applicant request a waiver of the planning consortium requirement?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false How does an applicant request a waiver of the planning... Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION URBAN COMMUNITY SERVICE PROGRAM How Does One Apply for an Award? § 636.11 How does an applicant request a waiver of the...

  7. 34 CFR 636.11 - How does an applicant request a waiver of the planning consortium requirement?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false How does an applicant request a waiver of the planning... Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION URBAN COMMUNITY SERVICE PROGRAM How Does One Apply for an Award? § 636.11 How does an applicant request a waiver of the...

  8. 34 CFR 636.11 - How does an applicant request a waiver of the planning consortium requirement?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false How does an applicant request a waiver of the planning... Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION URBAN COMMUNITY SERVICE PROGRAM How Does One Apply for an Award? § 636.11 How does an applicant request a waiver of the...

  9. 10 CFR 490.602 - Special orders.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Special orders. 490.602 Section 490.602 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.602 Special orders. (a) DOE may require by general or special orders that any person— (1) File,...

  10. 10 CFR 490.602 - Special orders.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Special orders. 490.602 Section 490.602 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.602 Special orders. (a) DOE may require by general or special orders that any person— (1) File,...

  11. 10 CFR 490.602 - Special orders.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Special orders. 490.602 Section 490.602 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.602 Special orders. (a) DOE may require by general or special orders that any person— (1) File,...

  12. 10 CFR 490.602 - Special orders.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Special orders. 490.602 Section 490.602 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.602 Special orders. (a) DOE may require by general or special orders that any person— (1) File,...

  13. 10 CFR 490.602 - Special orders.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Special orders. 490.602 Section 490.602 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.602 Special orders. (a) DOE may require by general or special orders that any person— (1) File,...

  14. Teaching to the Test…or Testing to Teach: Exams Requiring Higher Order Thinking Skills Encourage Greater Conceptual Understanding

    ERIC Educational Resources Information Center

    Jensen, Jamie L.; McDaniel, Mark A.; Woodard, Steven M.; Kummer, Tyler A.

    2014-01-01

    In order to test the effect of exam-question level on fostering student conceptual understanding, low-level and high-level quizzes and exams were administered in two sections of an introductory biology course. Each section was taught in a high-level inquiry based style but was assigned either low-level questions (memory oriented) on the quizzes…

  15. 77 FR 16091 - Order Modifying Licenses With Regard to Requirements for Mitigation Strategies for Beyond-Design...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ... would be available if the loss of power, motive force, and normal access to the ultimate heat sink to... accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires... (ac) power and loss of normal access to the ultimate heat sink and have adequate capacity to...

  16. 48 CFR 8.405-1 - Ordering procedures for supplies, and services not requiring a statement of work.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... surveying at least three schedule contractors through the GSA Advantage! on-line shopping service, by... placed on a competitive basis in accordance with (d)(2) and (3) of this section, unless this requirement... brand-name specifications, the contracting officer shall post the RFQ on e-Buy along with...

  17. 48 CFR 8.405-1 - Ordering procedures for supplies, and services not requiring a statement of work.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... surveying at least three schedule contractors through the GSA Advantage! on-line shopping service, by... placed on a competitive basis in accordance with (d)(2) and (3) of this section, unless this requirement... brand-name specifications, the contracting officer shall post the RFQ on e-Buy along with...

  18. 48 CFR 8.405-1 - Ordering procedures for supplies, and services not requiring a statement of work.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... surveying at least three schedule contractors through the GSA Advantage! on-line shopping service, by... placed on a competitive basis in accordance with (d)(2) and (3) of this section, unless this requirement... brand-name specifications, the contracting officer shall post the RFQ on e-Buy along with...

  19. 48 CFR 8.405-1 - Ordering procedures for supplies, and services not requiring a statement of work.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... multiple award schedule(s) an opportunity to submit a quote; or (ii) Provide the RFQ to as many schedule... ensure that quotes will be received from at least three contractors that can fulfill the requirements. When fewer than three quotes are received from schedule contractors that can fulfill the...

  20. Selection of a Propulsion System for Jason-CS in Order to Fulfil Space Debris Mitigation Requirements for ESA Project

    NASA Astrophysics Data System (ADS)

    Barthen, Bjoern; Beck, Jan; Duske, Norbert; Francis, Richard; Koeble, Klaus-Peter

    2013-08-01

    For two decades, the mission Topex-Poseidon and its successor mission Jason/Ocean Surface Topography Mission provide satellite data for the analysis of sea topography, wave heights and wind speeds. For the continuation of service mission Jason-CS, ESA's choice to rely on the CryoSat-2 platform design permits re-use of a well established product and proven processes. An industrial consortium led by Astrium GmbH has built the satellite CryoSat-2 which for over three years successfully provides altimeter measurements of the polar ice cap thickness evolutions. This platform is perfectly suited for accommodation of the Jason-CS instruments. Unlike CryoSat-2, Jason-CS is required to perform a post-mission disposal according to the Requirements for Space Debris Mitigation for ESA Projects. This paper discusses different technologies in terms of efficiency, feasibility and accommodation, aiming at minimizing necessary spacecraft design modifications.

  1. Measurement and Development of Humanware and Technoware Competencies in Order to Meet Pintle Chain Product Requirements in Bandung Manufacture Polytechnic

    NASA Astrophysics Data System (ADS)

    Akbar, Jodi; Akbar, Muhammad; Irianto, Dradjad

    2016-02-01

    Politeknik Manufaktur Bandung (Bandung Manufacture Polytechnic) is a polytechnic education that is not only to educate their students, but also manufactures order from customers at its teaching factory. This polytechnic is usually not responsive with the number of reject due to amateur operators from newcomer students. However, customers will be displeased if the reject rate is too high which can cause delay of delivery. At the foundry section, pintle chain is a product that has the highest amount of quantity but the lowest product standard fulfilment. Realizing this problem, it is a strong need to give more focus on quality improvement. The polytechnic considers that bad quality is not only related to low level of humanware (operator) but also related to low level of technoware (machine and equipment). In this research, QFD model was used as a tool for identifying target of improvement of non conforming factors of humanware and technoware using UNESCAP's technometric model. An improvement was done by implementing new scheduling strategy at foundry unit in order to minimize waiting time from molding to pouring process because of deterioration problem. This strategy provides an opportunity to reduce completion times about 50% and waiting time about 95% compared to the existing scheduling strategy.

  2. 14 CFR 382.27 - May a carrier require a passenger with a disability to provide advance notice in order to obtain...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false May a carrier require a passenger with a disability to provide advance notice in order to obtain certain specific services in connection with a flight? 382.27 Section 382.27 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL...

  3. 25 CFR 39.214 - What is the minimum number of instructional hours required in order to be considered a full-time...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What is the minimum number of instructional hours required in order to be considered a full-time educational program? 39.214 Section 39.214 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN SCHOOL EQUALIZATION...

  4. 25 CFR 39.214 - What is the minimum number of instructional hours required in order to be considered a full-time...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What is the minimum number of instructional hours required in order to be considered a full-time educational program? 39.214 Section 39.214 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN SCHOOL EQUALIZATION...

  5. 25 CFR 39.214 - What is the minimum number of instructional hours required in order to be considered a full-time...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What is the minimum number of instructional hours required in order to be considered a full-time educational program? 39.214 Section 39.214 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN SCHOOL EQUALIZATION...

  6. 25 CFR 39.214 - What is the minimum number of instructional hours required in order to be considered a full-time...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the minimum number of instructional hours required in order to be considered a full-time educational program? 39.214 Section 39.214 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN SCHOOL EQUALIZATION...

  7. 25 CFR 39.214 - What is the minimum number of instructional hours required in order to be considered a full-time...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What is the minimum number of instructional hours required in order to be considered a full-time educational program? 39.214 Section 39.214 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN SCHOOL EQUALIZATION...

  8. 20 CFR 661.207 - How does the State Board meet its requirement to conduct business in an open manner under the...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false How does the State Board meet its requirement to conduct business in an open manner under the âsunshine provisionâ of WIA section 111(g)? 661.207 Section 661.207 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR...

  9. 20 CFR 661.307 - How does the Local Board meet its requirement to conduct business in an open manner under the...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... to conduct business in an open manner under the âsunshine provisionâ of WIA section 117(e)? 661.307...) STATEWIDE AND LOCAL GOVERNANCE OF THE WORKFORCE INVESTMENT SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Local Governance Provisions § 661.307 How does the Local Board meet its requirement to...

  10. 20 CFR 661.307 - How does the Local Board meet its requirement to conduct business in an open manner under the...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to conduct business in an open manner under the âsunshine provisionâ of WIA section 117(e)? 661.307... AND LOCAL GOVERNANCE OF THE WORKFORCE INVESTMENT SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Local Governance Provisions § 661.307 How does the Local Board meet its requirement to conduct...

  11. 20 CFR 661.307 - How does the Local Board meet its requirement to conduct business in an open manner under the...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... to conduct business in an open manner under the âsunshine provisionâ of WIA section 117(e)? 661.307...) STATEWIDE AND LOCAL GOVERNANCE OF THE WORKFORCE INVESTMENT SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Local Governance Provisions § 661.307 How does the Local Board meet its requirement to...

  12. 20 CFR 661.307 - How does the Local Board meet its requirement to conduct business in an open manner under the...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... to conduct business in an open manner under the âsunshine provisionâ of WIA section 117(e)? 661.307... AND LOCAL GOVERNANCE OF THE WORKFORCE INVESTMENT SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Local Governance Provisions § 661.307 How does the Local Board meet its requirement to conduct...

  13. 20 CFR 661.307 - How does the Local Board meet its requirement to conduct business in an open manner under the...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... to conduct business in an open manner under the âsunshine provisionâ of WIA section 117(e)? 661.307...) STATEWIDE AND LOCAL GOVERNANCE OF THE WORKFORCE INVESTMENT SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Local Governance Provisions § 661.307 How does the Local Board meet its requirement to...

  14. 14 CFR 39.9 - What if I operate an aircraft or use a product that does not meet the requirements of an...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false What if I operate an aircraft or use a product that does not meet the requirements of an airworthiness directive? 39.9 Section 39.9 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT...

  15. 20 CFR 664.320 - Does the requirement that at least 30 percent of youth funds be used to provide activities to out...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of youth funds be used to provide activities to out-of-school youth apply to all youth funds? 664.320... ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Out-of-School Youth § 664.320 Does the requirement that at least 30 percent of youth funds be used to provide activities to out-of-school youth apply...

  16. 20 CFR 664.320 - Does the requirement that at least 30 percent of youth funds be used to provide activities to out...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of youth funds be used to provide activities to out-of-school youth apply to all youth funds? 664.320... ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Out-of-School Youth § 664.320 Does the requirement that at least 30 percent of youth funds be used to provide activities to out-of-school youth apply...

  17. Cross-Modal Plasticity in Higher-Order Auditory Cortex of Congenitally Deaf Cats Does Not Limit Auditory Responsiveness to Cochlear Implants

    PubMed Central

    Baumhoff, Peter; Tillein, Jochen; Lomber, Stephen G.; Hubka, Peter; Kral, Andrej

    2016-01-01

    over the unused cortex and reassigns it to the remaining senses. Therefore, cross-modal plasticity might conflict with restoration of auditory function with cochlear implants. It is unclear whether the cross-modally reorganized auditory areas lose auditory responsiveness. We show that the presence of cross-modal plasticity in a higher-order auditory area does not reduce auditory responsiveness of that area. Visual reorganization was moderate, spatially scattered and there were no interactions between cross-modally reorganized visual and auditory inputs. These results indicate that cross-modal reorganization is less detrimental for neurosensory restoration than previously thought. PMID:27277796

  18. Quantifying and Addressing the DOE Material Reactivity Requirements with Analysis and Testing of Hydrogen Storage Materials & Systems

    SciTech Connect

    Khalil, Y. F

    2015-01-05

    The objective of this project is to examine safety aspects of candidate hydrogen storage materials and systems being developed in the DOE Hydrogen Program. As a result of this effort, the general DOE safety target will be given useful meaning by establishing a link between the characteristics of new storage materials and the satisfaction of safety criteria. This will be accomplished through the development and application of formal risk analysis methods, standardized materials testing, chemical reactivity characterization, novel risk mitigation approaches and subscale system demonstration. The project also will collaborate with other DOE and international activities in materials based hydrogen storage safety to provide a larger, highly coordinated effort.

  19. High-order adaptive optics requirements for direct detection of extrasolar planets: Application to the SPHERE instrument.

    PubMed

    Fusco, T; Rousset, G; Sauvage, J-F; Petit, C; Beuzit, J-L; Dohlen, K; Mouillet, D; Charton, J; Nicolle, M; Kasper, M; Baudoz, P; Puget, P

    2006-08-21

    The detection of extrasolar planets implies an extremely high-contrast, long-exposure imaging capability at near infrared and probably visible wavelengths. We present here the core of any Planet Finder instrument, that is, the extreme adaptive optics (XAO) subsystem. The level of AO correction directly impacts the exposure time required for planet detection. In addition, the capacity of the AO system to calibrate all the instrument static defects ultimately limits detectivity. Hence, the extreme AO system has to adjust for the perturbations induced by the atmospheric turbulence, as well as for the internal aberrations of the instrument itself. We propose a feasibility study for an extreme AO system in the frame of the SPHERE (Spectro-Polarimetry High-contrast Exoplanet Research) instrument, which is currently under design and should equip one of the four VLT 8-m telescopes in 2010. PMID:19529118

  20. Standard for developing and issuing DOE safety guides and implementation guides

    SciTech Connect

    Not Available

    1994-07-01

    This standard establishes the style, format, content, and process for preparing and issuing DOE guides. It is intended for use by all DOE components, including contractors. The DOE guides provide information on DOE`s expectations on meeting the provisions of rules, orders, notices, manuals, immediate action directives, and regulatory standards (requirements documents) or policies.

  1. DOE standard: Firearms safety

    SciTech Connect

    1996-02-01

    Information in this document is applicable to all DOE facilities, elements, and contractors engaged in work that requires the use of firearms as provided by law or contract. The standard in this document provides principles and practices for implementing a safe and effective firearms safety program for protective forces and for non-security use of firearms. This document describes acceptable interpretations and methods for meeting Order requirements.

  2. A practical exercise in assessing order compliance

    SciTech Connect

    Hallinan, E.J.

    1993-04-01

    Two orders impacting DOE nuclear safety analyses were issued in 1992: DOE 5480.22, ``Technical Safety Requirements,`` and DOE 5480.23, ``Nuclear Safety Analysis Reports.`` Both orders required submitting plans and schedules for compliance with the new requirements by 6 months from the issuance dates. These assessments resulted in a major effort by the Westinghouse Savannah River Co. (WSRC) for some 30 current and future safety analyses that span three Program Secretarial Offices. Further, the local field office expressed a vital interest in determining the shape of compliance for site nuclear operations. Thus, a team of about 20 people were involved in: Interpreting and obtaining concurrence with implementation issues; identifying applicable nuclear facilities; baselining the status of compliance with previous requirements; comparing new to previous requirements; scheduling future activities to achieve compliance with the new requirements; estimating baseline and additional costs; and obtaining management approvals.

  3. A practical exercise in assessing order compliance

    SciTech Connect

    Hallinan, E.J.

    1993-01-01

    Two orders impacting DOE nuclear safety analyses were issued in 1992: DOE 5480.22, Technical Safety Requirements,'' and DOE 5480.23, Nuclear Safety Analysis Reports.'' Both orders required submitting plans and schedules for compliance with the new requirements by 6 months from the issuance dates. These assessments resulted in a major effort by the Westinghouse Savannah River Co. (WSRC) for some 30 current and future safety analyses that span three Program Secretarial Offices. Further, the local field office expressed a vital interest in determining the shape of compliance for site nuclear operations. Thus, a team of about 20 people were involved in: Interpreting and obtaining concurrence with implementation issues; identifying applicable nuclear facilities; baselining the status of compliance with previous requirements; comparing new to previous requirements; scheduling future activities to achieve compliance with the new requirements; estimating baseline and additional costs; and obtaining management approvals.

  4. Power requirements for cosmic ray propagation models involving re-acceleration and a comment on second-order Fermi acceleration theory

    NASA Astrophysics Data System (ADS)

    Thornbury, Andrew; Drury, Luke O'C.

    2014-08-01

    We derive an analytic expression for the power transferred from interstellar turbulence to the Galactic cosmic rays in propagation models which include re-acceleration. This is used to estimate the power required in such models and the relative importance of the primary acceleration as against re-acceleration. The analysis provides a formal mathematical justification for Fermi's heuristic account of second-order acceleration in his classic 1949 paper.

  5. 31 CFR 30.7 - Q-7: How does a TARP recipient comply with the certification and disclosure requirements under...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... pursuant to Item 407(e) of Regulation S-K under the Federal securities laws (17 CFR 229.407(e)) and to... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Q-7: How does a TARP recipient comply... Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION...

  6. 31 CFR 30.7 - Q-7: How does a TARP recipient comply with the certification and disclosure requirements under...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... pursuant to Item 407(e) of Regulation S-K under the Federal securities laws (17 CFR 229.407(e)) and to... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Q-7: How does a TARP recipient comply... Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION...

  7. 31 CFR 30.7 - Q-7: How does a TARP recipient comply with the certification and disclosure requirements under...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... pursuant to Item 407(e) of Regulation S-K under the Federal securities laws (17 CFR 229.407(e)) and to... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Q-7: How does a TARP recipient comply... Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION...

  8. 31 CFR 30.7 - Q-7: How does a TARP recipient comply with the certification and disclosure requirements under...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... pursuant to Item 407(e) of Regulation S-K under the Federal securities laws (17 CFR 229.407(e)) and to... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Q-7: How does a TARP recipient comply... Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION...

  9. 41 CFR 102-118.25 - Does GSA still require my agency to submit its overall transportation policies for approval?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT General Introduction... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Does GSA still...

  10. 31 CFR 30.7 - Q-7: How does a TARP recipient comply with the certification and disclosure requirements under...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... pursuant to Item 407(e) of Regulation S-K under the Federal securities laws (17 CFR 229.407(e)) and to... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Q-7: How does a TARP recipient comply... Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION...

  11. 20 CFR 655.1110 - What requirements does the NRDAA impose in the filing of an Attestation?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Requirements Must a Facility Meet to Employ H-1C Nonimmigrant Workers as Registered Nurses? § 655.1110 What...) requires a prospective employer of H-1C nurses to attest to the following: (1) That it qualifies as a “facility” (See § 655.1111); (2) That employment of H-1C nurses will not adversely affect the wages...

  12. Seed germination of GA-insensitive sleepy1 mutants does not require RGL2 protein disappearance in Arabidopsis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Seed germination is a complex developmental process regulated by phytohormones. The phytohormone abscisic acid (ABA) inhibits seed germination, whereas gibberellin (GA) stimulates seed germination. In tomato and Arabidopsis, GA is clearly required for seed germination. Recent evidence suggests tha...

  13. Compliance with the Clean Air Act Title VI Stratospheric Ozone Protection Program requirements at U.S. DOE Oak Ridge Reservation Facilities

    SciTech Connect

    Humphreys, M.P.; Atkins, E.M.

    1999-07-01

    The Title VI Stratospheric Ozone Protection Program of the Clean Air Act (CAA) requires promulgation of regulations to reduce and prevent damage to the earth's protective ozone layer. Regulations pursuant to Title VI of the CAA are promulgated in the Code of Federal Regulations (CFR) at Title 40 CFR, Part 822. The regulations include ambitious production phaseout schedules for ozone depleting substances (ODS) including chlorofluorocarbons (CFCs), hydrochlorofluorocarbons (HCFCs), halons, carbon tetrachloride, and methyl chloroform under 40 CFR 82, Subpart A. The regulations also include requirements for recycling and emissions reduction during the servicing of refrigeration equipment and technician certification requirements under Subpart F; provisions for servicing of motor vehicle air conditioners under Subpart B; a ban on nonessential products containing Class 1 ODS under Subpart C; restrictions on Federal procurement of ODS under Subpart D; labeling of products using ODS under Subpart E; and the Significant New Alternatives Policy Program under Subpart G. This paper will provide details of initiatives undertaken at US Department of Energy (DOE) Oak Ridge Reservation (ORR) Facilities for implementation of requirements under the Title VI Stratospheric Ozone Protection Program. The Stratospheric Ozone Protection Plans include internal DOE requirements for: (1) maintenance of ODS inventories; (2) ODS procurement practices; (3) servicing of refrigeration and air conditioning equipment; (4) required equipment modifications or replacement; (5) technician certification training; (6) labeling of products containing ODS; (7) substitution of chlorinated solvents; and (8) replacement of halon fire protection systems. The plans also require establishment of administrative control systems which assure that compliance is achieved and maintained as the regulations continue to develop and become effective.

  14. Implementation of the Clean Air Act, Title V operating permit program requirements for the U.S. DOE Oak Ridge Reservation facilities

    SciTech Connect

    Humphreys, M.P.

    1998-12-31

    Title V of the Clean Air Act (CAA) establishes a new permit program requiring major sources and sources subject to Title III (Hazardous Air Pollutants) to obtain a state operating permit. Historically, most states have issued operating permits for individual emission units. Under the Title V permit program, a single permit will be issued for all of the emission units at the facility much like the current National Pollutant Discharge Elimination System (NPDES) permit program. The permit will specify all reporting, monitoring, and record-keeping requirements for the facility. Sources required to obtain permits include (a) major sources that emit 100 tons per year or more of any criteria air contaminant, (b) any source subject to the HAP provisions of Title III, (c) any source subject to the acid rain provisions of Title IV, (d) any source subject to New Source Performance Standards, and (e) any source subject to new source review under the nonattainment or Prevention of Significant Deterioration provisions. The State of Tennessee Title V Operating Permit Program was approved by EPA on August 28, 1996. This paper will provide details of initiatives underway at US Department of Energy (DOE) Oak Ridge Reservation (ORR) Facilities for implementation of requirements under the Title V Operating Permit Program. The ORR encompasses three DOE Facilities: the Y-12 Plant, Oak Ridge National Laboratory (ORNL), and the East Tennessee Technology Park (ETTP). The Y-12 Plant manufactures component parts for the national nuclear weapons program; the ORNL is responsible for research and development activities including nuclear engineering, engineering technologies, and the environmental sciences; and the ETTP conducts a variety of research and development activities and is the home of a mixed waste incinerator. Each of the three DOE Facilities is considered a major source under Title V of the CAA.

  15. Does the orbit-averaged theory require a scale separation between periodic orbit size and perturbation correlation length?

    SciTech Connect

    Zhang, Wenlu; Lin, Zhihong

    2013-10-15

    Using the canonical perturbation theory, we show that the orbit-averaged theory only requires a time-scale separation between equilibrium and perturbed motions and verifies the widely accepted notion that orbit averaging effects greatly reduce the microturbulent transport of energetic particles in a tokamak. Therefore, a recent claim [Hauff and Jenko, Phys. Rev. Lett. 102, 075004 (2009); Jenko et al., ibid. 107, 239502 (2011)] stating that the orbit-averaged theory requires a scale separation between equilibrium orbit size and perturbation correlation length is erroneous.

  16. 34 CFR 462.13 - What criteria and requirements does the Secretary use for determining the suitability of tests?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) and 1 CFR part 51. You may obtain a copy from the American Psychological Association, Inc., 750 First... consider a test suitable for use in the NRS, the test or the test publisher, if applicable, must meet the following criteria and requirements: (a) The test must measure the NRS educational functioning levels...

  17. 34 CFR 462.13 - What criteria and requirements does the Secretary use for determining the suitability of tests?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) and 1 CFR part 51. You may obtain a copy from the American Psychological Association, Inc., 750 First... consider a test suitable for use in the NRS, the test or the test publisher, if applicable, must meet the following criteria and requirements: (a) The test must measure the NRS educational functioning levels...

  18. 34 CFR 462.13 - What criteria and requirements does the Secretary use for determining the suitability of tests?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) and 1 CFR part 51. You may obtain a copy from the American Psychological Association, Inc., 750 First... consider a test suitable for use in the NRS, the test or the test publisher, if applicable, must meet the following criteria and requirements: (a) The test must measure the NRS educational functioning levels...

  19. 34 CFR 462.13 - What criteria and requirements does the Secretary use for determining the suitability of tests?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) and 1 CFR part 51. You may obtain a copy from the American Psychological Association, Inc., 750 First... consider a test suitable for use in the NRS, the test or the test publisher, if applicable, must meet the following criteria and requirements: (a) The test must measure the NRS educational functioning levels...

  20. 34 CFR 462.13 - What criteria and requirements does the Secretary use for determining the suitability of tests?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) and 1 CFR part 51. You may obtain a copy from the American Psychological Association, Inc., 750 First... consider a test suitable for use in the NRS, the test or the test publisher, if applicable, must meet the following criteria and requirements: (a) The test must measure the NRS educational functioning levels...

  1. How Does the New TANF Work Requirement "Work" in Rural Minority Communities? A Case Study of the Northern Cheyenne Nation

    ERIC Educational Resources Information Center

    Whiting, Erin Feinauer; Ward, Carol; Villa, Rita Hiwalker; Davis, Judith

    2005-01-01

    In August of 1996 Congress passed the Personal Responsibility and Work Opportunity Reconciliation Act (PRWORA), which President Bill Clinton then signed into law. This essay will address the question, how have American Indian reservation residents fared in relation to the new work requirements? The authors are interested in the consequences of…

  2. 7 CFR 400.171 - Qualifying when a state does not require that an Annual Statutory Financial Statement be filed.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Annual Statutory Financial Statement be filed. 400.171 Section 400.171 Agriculture Regulations of the... filing an Annual Statutory Financial Statement must, in addition to the requirements of § 400.170 (a), (b), (c) and (d), submit an Annual Statutory Financial Statement audited by a Certified Public...

  3. 13 CFR 124.603 - What reports regarding the continued business operations of former Participants does SBA require?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Credit and Assistance SMALL BUSINESS ADMINISTRATION 8(a) BUSINESS DEVELOPMENT/SMALL DISADVANTAGED BUSINESS STATUS DETERMINATIONS 8(a) Business Development Miscellaneous Reporting Requirements § 124.603... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false What reports regarding...

  4. 13 CFR 124.603 - What reports regarding the continued business operations of former Participants does SBA require?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Credit and Assistance SMALL BUSINESS ADMINISTRATION 8(a) BUSINESS DEVELOPMENT/SMALL DISADVANTAGED BUSINESS STATUS DETERMINATIONS 8(a) Business Development Miscellaneous Reporting Requirements § 124.603... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What reports regarding...

  5. 13 CFR 124.603 - What reports regarding the continued business operations of former Participants does SBA require?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Credit and Assistance SMALL BUSINESS ADMINISTRATION 8(a) BUSINESS DEVELOPMENT/SMALL DISADVANTAGED BUSINESS STATUS DETERMINATIONS 8(a) Business Development Miscellaneous Reporting Requirements § 124.603... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false What reports regarding...

  6. 13 CFR 124.603 - What reports regarding the continued business operations of former Participants does SBA require?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Credit and Assistance SMALL BUSINESS ADMINISTRATION 8(a) BUSINESS DEVELOPMENT/SMALL DISADVANTAGED BUSINESS STATUS DETERMINATIONS 8(a) Business Development Miscellaneous Reporting Requirements § 124.603... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false What reports regarding...

  7. 13 CFR 124.603 - What reports regarding the continued business operations of former Participants does SBA require?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Credit and Assistance SMALL BUSINESS ADMINISTRATION 8(a) BUSINESS DEVELOPMENT/SMALL DISADVANTAGED BUSINESS STATUS DETERMINATIONS 8(a) Business Development Miscellaneous Reporting Requirements § 124.603... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false What reports regarding...

  8. Diverting stoma with anterior resection for rectal cancer: does it reduce overall anastomotic leakage and leaks requiring laparotomy?

    PubMed Central

    Cong, Zhi-Jie; Hu, Liang-Hao; Zhong, Ming; Chen, Lu

    2015-01-01

    Anastomotic leakage (AL) after resection for rectal carcinoma accelerates morbidity and mortality rates, extends hospital stay, and increases treatment costs, particularly when requiring laparotomy. The role of a protective diverting stoma (DS) in avoiding leakage has repeatedly been discussed, but prospective randomized studies on this subject are rare and their results contradictory. The MEDLINE database was searched for studies of AL requiring laparotomy and of the associated rate of protective DSs in initial anterior resection (AR) to review these studies systematically. The collected data were used to determine the average rate of AL requiring laparotomy after rectal cancer surgery in the DS group compared with that in the non-DS group. A total of 930 abstracts were retrieved from MEDLINE; 15 articles on AR and 22 on low/ultralow AR (LAR) were included in the review and analysis. The overall rate of AL requiring laparotomy was 6.57% (813/12, 376) in the AR studies and 4.13% (157/3, 802) in the LAR studies. In the AR studies, the pooled AL rate in the DS group was higher than that in the non-DS group (12.30% vs. 9.16%, P < 0.001). However, the pooled rate of AL requiring laparotomy in the DS group was lower than that in the non-DS group (3.69% vs. 7.42%, P < 0.001). In the LAR studies, the pooled AL rate in the DS group was lower than that in the non-DS group (7.74% vs. 9.64%, P = 0.045). The pooled rate of AL requiring laparotomy in the DS group was also lower than that in the non-DS group (2.67% vs. 5.21%, P < 0.001). By contrast, the pooled rate of definitive stomas and mortality caused by AL did not have any statistical difference between the DS and non-DS groups in both AR studies (definitive stomas: 0% vs. 0.65%; mortality: 0.95% vs. 1.19%) and LAR studies (definitive stomas: 1.03% vs. 1.01%; mortality: 0.35% vs. 0.36%). Protective DSs significantly decrease the rate of AL in LAR. AL requiring surgical correction was significantly reduced in the DS group

  9. Radiation Exposures for DOE and DOE Contractor Employees - 1990. Twenty-third annual report

    SciTech Connect

    Smith, M. H.; Hui, T. E.; Millet, W. H.; Scholes, V. A.

    1993-11-01

    All U.S. Department of Energy and DOE contractors are required by DOE Order 5484.1, Chapter IV, to submit occupational radiation exposure records to a central depository. For 1990, data were required to be submitted for all employees who were required to be monitored in accordance with DOE Order 5480.11 and for all visitors who had a positive exposure. The data required included the total effective dose equivalent, external penetrating whole-body dose equivalent, internal dose equivalent, the shallow dose equivalent, neutron dose equivalent, and extremity dose equivalent. Data regarding the exposed individuals included the individual's age, sex, and occupation category. This report is a summary of data reported by DOE and DOE contractors for the calendar year 1990.

  10. Delayed action does not always require the ventral stream: a study on a patient with visual form agnosia.

    PubMed

    Hesse, Constanze; Schenk, Thomas

    2014-05-01

    It has been suggested that while movements directed at visible targets are processed within the dorsal stream, movements executed after delay rely on the visual representations of the ventral stream (Milner & Goodale, 2006). This interpretation is supported by the observation that a patient with ventral stream damage (D.F.) has trouble performing accurate movements after a delay, but performs normally when the target is visible during movement programming. We tested D.F.'s visuomotor performance in a letter-posting task whilst varying the amount of visual feedback available. Additionally, we also varied whether D.F. received tactile feedback at the end of each trial (posting through a letter box vs posting on a screen) and whether environmental cues were available during the delay period (removing the target only vs suppressing vision completely with shutter glasses). We found that in the absence of environmental cues patient D.F. was unaffected by the introduction of delay and performed as accurately as healthy controls. However, when environmental cues and vision of the moving hand were available during and after the delay period, D.F.'s visuomotor performance was impaired. Thus, while healthy controls benefit from the availability of environmental landmarks and/or visual feedback of the moving hand, such cues seem less beneficial to D.F. Taken together our findings suggest that ventral stream damage does not always impact the ability to make delayed movements but compromises the ability to use environmental landmarks and visual feedback efficiently. PMID:24657477

  11. Comparison and Analysis of Regulatory and Derived Requirements for Certain DOE Spent Nuclear Fuel Shipments; Lessons Learned for Future Spent Fuel Transportation Campaigns

    SciTech Connect

    Kramer, George L., Ph.D.; Fawcett, Rick L.; Rieke, Philip C.

    2003-02-27

    Radioactive materials transportation is stringently regulated by the Department of Transportation and the Nuclear Regulatory Commission to protect the public and the environment. As a Federal agency, however, the U.S. Department of Energy (DOE) must seek State, Tribal and local input on safety issues for certain transportation activities. This interaction has invariably resulted in the imposition of extra-regulatory requirements, greatly increasing transportation costs and delaying schedules while not significantly enhancing the level of safety. This paper discusses the results an analysis of the regulatory and negotiated requirements established for a July 1998 shipment of spent nuclear fuel from foreign countries through the west coast to the Idaho National Engineering and Environmental Laboratory (INEEL). Staff from the INEEL Nuclear Materials Engineering and Disposition Department undertook the analysis in partnership with HMTC, to discover if there were instances where requirements derived from stakeholder interactions duplicate, contradict, or otherwise overlap with regulatory requirements. The study exhaustively lists and classifies applicable Department of Transportation (DOT) and Nuclear Regulatory Commission (NRC) regulations. These are then compared with a similarly classified list of requirements from the Environmental Impact Statements (EIS) and those developed during stakeholder negotiations. Comparison and analysis reveals numerous attempts to reduce transportation risk by imposing more stringent safety measures than those required by DOT and NRC. These usually took the form of additional inspection, notification and planning requirements. There are also many instances of overlap with, and duplication of regulations. Participants will gain a greater appreciation for the need to understand the risk-oriented basis of the radioactive materials regulations and their effectiveness in ensuring safety when negotiating extra-regulatory requirements.

  12. Inactivation of Retinoblastoma Protein Does Not Overcome the Requirement for Human Cytomegalovirus UL97 in Lamina Disruption and Nuclear Egress

    PubMed Central

    Reim, Natalia I.; Wang, Depeng; Lin, Alison; Sharma, Mayuri; Ericsson, Maria; Pesola, Jean M.; Golan, David E.

    2013-01-01

    Human cytomegalovirus (HCMV) encodes one conventional protein kinase, UL97. During infection, UL97 phosphorylates the retinoblastoma tumor suppressor protein (pRb) on sites ordinarily phosphorylated by cyclin-dependent kinases (CDK), inactivating the ability of pRb to repress host genes required for cell cycle progression to S phase. UL97 is important for viral DNA synthesis in quiescent cells, but this function can be replaced by human papillomavirus type 16 E7, which targets pRb for degradation. However, viruses in which E7 replaces UL97 are still defective for virus production. UL97 is also required for efficient nuclear egress of viral nucleocapsids, which is associated with disruption of the nuclear lamina during infection, and phosphorylation of lamin A/C on serine 22, which antagonizes lamin polymerization. We investigated whether inactivation of pRb might overcome the requirement of UL97 for these roles, as pRb inactivation induces CDK1, and CDK1 phosphorylates lamin A/C on serine 22. We found that lamin A/C serine 22 phosphorylation during HCMV infection correlated with expression of UL97 and was considerably delayed in UL97-null mutants, even when E7 was expressed. E7 failed to restore gaps in the nuclear lamina seen in wild-type but not UL97-null virus infections. In electron microscopy analyses, a UL97-null virus expressing E7 was as impaired as a UL97-null mutant in cytoplasmic accumulation of viral nucleocapsids. Our results demonstrate that pRb inactivation is insufficient to restore efficient viral nuclear egress of HCMV in the absence of UL97 and instead argue further for a direct role of UL97 in this stage of the infectious cycle. PMID:23427156

  13. Federal Environmental Reporting Requirements Handbook

    SciTech Connect

    1990-05-01

    The Environmental Reporting Requirements Handbook has been developed by DOE Headquarters' Environmental Guidance Division (EH-231) in order to assist DOE Field Organizations in the identification of the various reporting the notification requirements mandated by Federal environmental laws, regulations, and Executive Orders. The Handbook makes a distinction between ''routine'' and ''non-routine'' reporting/notification requirements. Routine reporting requirements include the submission of documents that are required either on a regular basis, such as annual or biennial reports, or periodic notifications that result from what would be considered ''normal'' operations, such as Material Safety Data Sheet (MSDS) updates that are required when new information not contained on previous MSDS submissions is discovered. Non-routine reporting requirements are generally associated with occurrences that represent significant deviations from regulated or planned performance; examples include the unintentional discharge of oil or hazardous substances.

  14. Long-term maintenance of hematopoietic stem cells does not require contact with embryo-derived stromal cells in cocultures.

    PubMed

    Oostendorp, Robert A J; Robin, Catherine; Steinhoff, Christine; Marz, Stefanie; Bräuer, Rosalinde; Nuber, Ulrike A; Dzierzak, Elaine A; Peschel, Christian

    2005-01-01

    We recently established that two midgestation-derived stromal clones--UG26-1B6, urogenital ridge-derived, and EL08-1D2, embryonic liver-derived--support the maintenance of murine adult bone marrow and human cord blood hematopoietic repopulating stem cells (HSCs). In this study, we investigate whether direct HSC-stroma contact is required for this stem cell maintenance. Adult bone marrow ckit+ Ly-6C- side population (K6-SP) cells and stromal cells were cocultured under contact or noncontact conditions. These experiments showed that HSCs were maintained for at least 4 weeks in culture and that direct contact between HSCs and stromal cells was not required. To find out which factors might be involved in HSC maintenance, we compared the gene expression profile of EL08-1D2 and UG26-1B6 with four HSC-nonsupportive clones. We found that EL08-1D2 and UG26-1B6 both expressed 21 genes at a higher level, including the putative secreted factors fibroblast growth factor-7, insulin-like growth factor-binding proteins 3 and 4, pleiotrophin, pentaxin-related, and thrombospondin 2, whereas 11 genes, including GPX-3 and HSP27, were expressed at a lower level. In summary, we show for the first time long-term maintenance of adult bone marrow HSCs in stroma noncontact cultures and identify some secreted molecules that may be involved in this support. PMID:15917480

  15. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.

    PubMed

    Lee, Seung-Hye; Le Pichon, Claire E; Adolfsson, Oskar; Gafner, Valérie; Pihlgren, Maria; Lin, Han; Solanoy, Hilda; Brendza, Robert; Ngu, Hai; Foreman, Oded; Chan, Ruby; Ernst, James A; DiCara, Danielle; Hotzel, Isidro; Srinivasan, Karpagam; Hansen, David V; Atwal, Jasvinder; Lu, Yanmei; Bumbaca, Daniela; Pfeifer, Andrea; Watts, Ryan J; Muhs, Andreas; Scearce-Levie, Kimberly; Ayalon, Gai

    2016-08-01

    The spread of tau pathology correlates with cognitive decline in Alzheimer's disease. In vitro, tau antibodies can block cell-to-cell tau spreading. Although mechanisms of anti-tau function in vivo are unknown, effector function might promote microglia-mediated clearance. In this study, we investigated whether antibody effector function is required for targeting tau. We compared efficacy in vivo and in vitro of two versions of the same tau antibody, with and without effector function, measuring tau pathology, neuron health, and microglial function. Both antibodies reduced accumulation of tau pathology in Tau-P301L transgenic mice and protected cultured neurons against extracellular tau-induced toxicity. Only the full-effector antibody enhanced tau uptake in cultured microglia, which promoted release of proinflammatory cytokines. In neuron-microglia co-cultures, only effectorless anti-tau protected neurons, suggesting full-effector tau antibodies can induce indirect toxicity via microglia. We conclude that effector function is not required for efficacy, and effectorless tau antibodies may represent a safer approach to targeting tau. PMID:27475227

  16. MuSK induced experimental autoimmune myasthenia gravis does not require IgG1 antibody to MuSK.

    PubMed

    Küçükerden, Melike; Huda, Ruksana; Tüzün, Erdem; Yılmaz, Abdullah; Skriapa, Lamprini; Trakas, Nikos; Strait, Richard T; Finkelman, Fred D; Kabadayı, Sevil; Zisimopoulou, Paraskevi; Tzartos, Socrates; Christadoss, Premkumar

    2016-06-15

    Sera of myasthenia gravis (MG) patients with muscle-specific receptor kinase-antibody (MuSK-Ab) predominantly display the non-complement fixing IgG4 isotype. Similarly, mouse IgG1, which is the analog of human IgG4, is the predominant isotype in mice with experimental autoimmune myasthenia gravis (EAMG) induced by MuSK immunization. The present study was performed to determine whether IgG1 anti-MuSK antibody is required for immunized mice to develop EAMG. Results demonstrated a significant correlation between clinical severity of EAMG and levels of MuSK-binding IgG1+, IgG2+ and IgG3+ peripheral blood B cells in MuSK-immunized wild-type (WT) mice. Moreover, MuSK-immunized IgG1 knockout (KO) and WT mice showed similar EAMG severity, serum MuSK-Ab levels, muscle acetylcholine receptor concentrations, neuromuscular junction immunoglobulin and complement deposit ratios. IgG1 and IgG3 were the predominant anti-MuSK isotypes in WT and IgG1 KO mice, respectively. These observations demonstrate that non-IgG1 isotypes can mediate MuSK-EAMG pathogenesis. PMID:27235354

  17. Phosphorylation of the Saccharomyces cerevisiae La protein does not appear to be required for its functions in tRNA maturation and nascent RNA stabilization.

    PubMed Central

    Long, K S; Cedervall, T; Walch-Solimena, C; Noe, D A; Huddleston, M J; Annan, R S; Wolin, S L

    2001-01-01

    An abundant nuclear phosphoprotein, the La autoantigen, is the first protein to bind all newly synthesized RNA polymerase III transcripts. Binding by the La protein to the 3' ends of these RNAs stabilizes the nascent transcripts from exonucleolytic degradation. In the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, the La protein is required for the normal pathway of tRNA maturation. Experiments in which the human protein was expressed in S. pombe have suggested that phosphorylation of the La protein regulates tRNA maturation. To dissect the role of phosphorylation in La protein function, we used mass spectrometry to identify three sites of serine phosphorylation in the S. cerevisiae La protein Lhp1p. Mutant versions of Lhp1p, in which each of the serines was mutated to alanine, were expressed in yeast cells lacking Lhp1p. Using two-dimensional gel electrophoresis, we determined that we had identified and mutated all major sites of phosphorylation in Lhp1p. Lhp1p lacking all three phosphorylation sites was functional in several yeast strains that require Lhp1p for growth. Northern blotting revealed no effects of Lhp1p phosphorylation status on either pre-tRNA maturation or stabilization of nascent RNAs. Both wild-type and mutant Lhp1 proteins localized to both nucleoplasm and nucleoli, demonstrating that phosphorylation does not affect subcellular location. Thus, although La proteins from yeast to humans are phosphoproteins, phosphorylation does not appear to be required for any of the identified functions of the S. cerevisiae protein. PMID:11720288

  18. Pyrophosphate-Mediated Iron Acquisition from Transferrin in Neisseria meningitidis Does Not Require TonB Activity

    PubMed Central

    Biville, Francis; Brézillon, Christophe; Giorgini, Dario; Taha, Muhamed-Kheir

    2014-01-01

    The ability to acquire iron from various sources has been demonstrated to be a major determinant in the pathogenesis of Neisseria meningitidis. Outside the cells, iron is bound to transferrin in serum, or to lactoferrin in mucosal secretions. Meningococci can extract iron from iron-loaded human transferrin by the TbpA/TbpB outer membrane complex. Moreover, N. meningitidis expresses the LbpA/LbpB outer membrane complex, which can extract iron from iron-loaded human lactoferrin. Iron transport through the outer membrane requires energy provided by the ExbB-ExbD-TonB complex. After transportation through the outer membrane, iron is bound by periplasmic protein FbpA and is addressed to the FbpBC inner membrane transporter. Iron-complexing compounds like citrate and pyrophosphate have been shown to support meningococcal growth ex vivo. The use of iron pyrophosphate as an iron source by N. meningitidis was previously described, but has not been investigated. Pyrophosphate was shown to participate in iron transfer from transferrin to ferritin. In this report, we investigated the use of ferric pyrophosphate as an iron source by N. meningitidis both ex vivo and in a mouse model. We showed that pyrophosphate was able to sustain N. meningitidis growth when desferal was used as an iron chelator. Addition of a pyrophosphate analogue to bacterial suspension at millimolar concentrations supported N. meningitidis survival in the mouse model. Finally, we show that pyrophosphate enabled TonB-independent ex vivo use of iron-loaded human or bovine transferrin as an iron source by N. meningitidis. Our data suggest that, in addition to acquiring iron through sophisticated systems, N. meningitidis is able to use simple strategies to acquire iron from a wide range of sources so as to sustain bacterial survival. PMID:25290693

  19. Technical Cooperation Among Developing Countries (TCDC); What Does It Mean for Education Towards A New International Economic Order (N.I.E.O.)?

    ERIC Educational Resources Information Center

    Kutsch, Gerhard

    In this paper, one of a series of Unesco technical reports, the author examines the idea of "technical cooperation among developing countries" (TCDC) and how it might lead to a "new international economic order" (NIEO). The first part of the paper contains a short history of TCDC. TCDC is seen by many as a self-help cooperative venture restricted…

  20. Does the Order of Item Difficulty of the Addenbrooke's Cognitive Examination Add Anything to Subdomain Scores in the Clinical Assessment of Dementia?

    PubMed Central

    McGrory, Sarah; Starr, John M.; Shenkin, Susan D.; Austin, Elizabeth J.; Hodges, John R.

    2015-01-01

    Background The Addenbrooke's Cognitive Examination (ACE) is used to measure cognition across a range of domains in dementia. Identifying the order in which cognitive decline occurs across items, and whether this varies between dementia aetiologies could add more information to subdomain scores. Method ACE-Revised data from 350 patients were split into three groups: Alzheimer's type (n = 131), predominantly frontal (n = 119) and other frontotemporal lobe degenerative disorders (n = 100). Results of factor analysis and Mokken scaling analysis were compared. Results Principal component analysis revealed one factor for each group. Confirmatory factor analysis found that the one-factor model fit two samples poorly. Mokken analyses revealed different item ordering in terms of difficulty for each group. Conclusion The different patterns for each diagnostic group could aid in the separation of these different types of dementia. PMID:25999982

  1. DOE Standard: Fire protection design criteria

    SciTech Connect

    Not Available

    1999-07-01

    The development of this Standard reflects the fact that national consensus standards and other design criteria do not comprehensively or, in some cases, adequately address fire protection issues at DOE facilities. This Standard provides supplemental fire protection guidance applicable to the design and construction of DOE facilities and site features (such as water distribution systems) that are also provided for fire protection. It is intended to be used in conjunction with the applicable building code, National Fire Protection Association (NFPA) Codes and Standards, and any other applicable DOE construction criteria. This Standard replaces certain mandatory fire protection requirements that were formerly in DOE 5480.7A, ``Fire Protection``, and DOE 6430.1A, ``General Design Criteria``. It also contains the fire protection guidelines from two (now canceled) draft standards: ``Glove Box Fire Protection`` and ``Filter Plenum Fire Protection``. (Note: This Standard does not supersede the requirements of DOE 5480.7A and DOE 6430.1A where these DOE Orders are currently applicable under existing contracts.) This Standard, along with the criteria delineated in Section 3, constitutes the basic criteria for satisfying DOE fire and life safety objectives for the design and construction or renovation of DOE facilities.

  2. 48 CFR 13.302-4 - Termination or cancellation of purchase orders.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... action is required (i.e., the purchase order shall be considered canceled). (2) If the contractor does... cancellation of purchase orders. 13.302-4 Section 13.302-4 Federal Acquisition Regulations System FEDERAL... Acquisition Methods 13.302-4 Termination or cancellation of purchase orders. (a) If a purchase order that...

  3. 48 CFR 13.302-4 - Termination or cancellation of purchase orders.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... action is required (i.e., the purchase order shall be considered canceled). (2) If the contractor does... cancellation of purchase orders. 13.302-4 Section 13.302-4 Federal Acquisition Regulations System FEDERAL... Acquisition Methods 13.302-4 Termination or cancellation of purchase orders. (a) If a purchase order that...

  4. 48 CFR 13.302-4 - Termination or cancellation of purchase orders.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... action is required (i.e., the purchase order shall be considered canceled). (2) If the contractor does... cancellation of purchase orders. 13.302-4 Section 13.302-4 Federal Acquisition Regulations System FEDERAL... Acquisition Methods 13.302-4 Termination or cancellation of purchase orders. (a) If a purchase order that...

  5. Environmental Requirements Management

    SciTech Connect

    Cusack, Laura J.; Bramson, Jeffrey E.; Archuleta, Jose A.; Frey, Jeffrey A.

    2015-01-08

    CH2M HILL Plateau Remediation Company (CH2M HILL) is the U.S. Department of Energy (DOE) prime contractor responsible for the environmental cleanup of the Hanford Site Central Plateau. As part of this responsibility, the CH2M HILL is faced with the task of complying with thousands of environmental requirements which originate from over 200 federal, state, and local laws and regulations, DOE Orders, waste management and effluent discharge permits, Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) response and Resource Conservation and Recovery Act (RCRA) corrective action documents, and official regulatory agency correspondence. The challenge is to manage this vast number of requirements to ensure they are appropriately and effectively integrated into CH2M HILL operations. Ensuring compliance with a large number of environmental requirements relies on an organization’s ability to identify, evaluate, communicate, and verify those requirements. To ensure that compliance is maintained, all changes need to be tracked. The CH2M HILL identified that the existing system used to manage environmental requirements was difficult to maintain and that improvements should be made to increase functionality. CH2M HILL established an environmental requirements management procedure and tools to assure that all environmental requirements are effectively and efficiently managed. Having a complete and accurate set of environmental requirements applicable to CH2M HILL operations will promote a more efficient approach to: • Communicating requirements • Planning work • Maintaining work controls • Maintaining compliance

  6. Intermittent-access binge consumption of sweet high-fat liquid does not require opioid or dopamine receptors in the nucleus accumbens.

    PubMed

    Lardeux, Sylvie; Kim, James J; Nicola, Saleem M

    2015-10-01

    Binge eating disorders are characterized by episodes of intense consumption of high-calorie food. In recently developed animal models of binge eating, rats given intermittent access to such food escalate their consumption over time. Consumption of calorie-dense food is associated with neurochemical changes in the nucleus accumbens, including dopamine release and alterations in dopamine and opioid receptor expression. Therefore, we hypothesized that binge-like consumption on intermittent access schedules is dependent on opioid and/or dopamine neurotransmission in the accumbens. To test this hypothesis, we asked whether injection of dopamine and opioid receptor antagonists into the core and shell of the accumbens reduced consumption of a sweet high-fat liquid in rats with and without a history of intermittent binge access to the liquid. Although injection of a μ opioid agonist increased consumption, none of the antagonists (including μ opioid, δ opioid, κ opioid, D1 dopamine and D2 dopamine receptor antagonists, as well as the broad-spectrum opioid receptor antagonist naltrexone) reduced consumption, and this was the case whether or not the animals had a prior history of intermittent access. These results suggest that consumption of sweet, fatty food does not require opioid or dopamine receptor activation in the accumbens even under intermittent access conditions that resemble human binge episodes. PMID:26097003

  7. Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis

    PubMed Central

    Amoyel, Marc; Sanny, Justina; Burel, Michael; Bach, Erika A.

    2013-01-01

    The Drosophila testis harbors two types of stem cells: germ line stem cells (GSCs) and cyst stem cells (CySCs). Both stem cell types share a physical niche called the hub, located at the apical tip of the testis. The niche produces the JAK/STAT ligand Unpaired (Upd) and BMPs to maintain CySCs and GSCs, respectively. However, GSCs also require BMPs produced by CySCs, and as such CySCs are part of the niche for GSCs. Here we describe a role for another secreted ligand, Hedgehog (Hh), produced by niche cells, in the self-renewal of CySCs. Hh signaling cell-autonomously regulates CySC number and maintenance. The Hh and JAK/STAT pathways act independently and non-redundantly in CySC self-renewal. Finally, Hh signaling does not contribute to the niche function of CySCs, as Hh-sustained CySCs are unable to maintain GSCs in the absence of Stat92E. Therefore, the extended niche function of CySCs is solely attributable to JAK/STAT pathway function. PMID:23175633

  8. The Fe-type nitrile hydratase from Comamonas testosteroni Ni1 does not require an activator accessory protein for expression in Escherichia coli

    SciTech Connect

    Kuhn, Misty L.; Martinez, Salette; Gumataotao, Natalie; Bornscheuer, Uwe; Liu, Dali; Holz, Richard C.

    2012-10-10

    We report herein the functional expression of an Fe-type nitrile hydratase (NHase) without the co-expression of an activator protein or the Escherichia coli chaperone proteins GroES/EL. Soluble protein was obtained when the {alpha}- and {beta}-subunit genes of the Fe-type NHase Comamonas testosteroni Ni1 (CtNHase) were synthesized with optimized E. coli codon usage and co-expressed. As a control, the Fe-type NHase from Rhodococcus equi TG328-2 (ReNHase) was expressed with (ReNHase{sup +Act}) and without (ReNHase{sup -Act}) its activator protein, establishing that expression of a fully functional, metallated ReNHase enzyme requires the co-expression of its activator protein, similar to all other Fe-type NHase enzymes reported to date, whereas the CtNHase does not. The X-ray crystal structure of CtNHase was determined to 2.4 {angstrom} resolution revealing an {alpha}{beta} heterodimer, similar to other Fe-type NHase enzymes, except for two important differences. First, two His residues reside in the CtNHase active site that are not observed in other Fe-type NHase enzymes and second, the active site Fe(III) ion resides at the bottom of a wide solvent exposed channel. The solvent exposed active site, along with the two active site histidine residues, are hypothesized to play a role in iron incorporation in the absence of an activator protein.

  9. The F4 fimbrial chaperone FaeE is stable as a monomer that does not require self-capping of its pilin-interactive surfaces.

    PubMed

    Van Molle, Inge; Moonens, Kristof; Buts, Lieven; Garcia-Pino, Abel; Panjikar, Santosh; Wyns, Lode; De Greve, Henri; Bouckaert, Julie

    2009-05-01

    Many Gram-negative bacteria use the chaperone-usher pathway to express adhesive surface structures, such as fimbriae, in order to mediate attachment to host cells. Periplasmic chaperones are required to shuttle fimbrial subunits or pilins through the periplasmic space in an assembly-competent form. The chaperones cap the hydrophobic surface of the pilins through a donor-strand complementation mechanism. FaeE is the periplasmic chaperone required for the assembly of the F4 fimbriae of enterotoxigenic Escherichia coli. The FaeE crystal structure shows a dimer formed by interaction between the pilin-binding interfaces of the two monomers. Dimerization and tetramerization have been observed previously in crystal structures of fimbrial chaperones and have been suggested to serve as a self-capping mechanism that protects the pilin-interactive surfaces in solution in the absence of the pilins. However, thermodynamic and biochemical data show that FaeE occurs as a stable monomer in solution. Other lines of evidence indicate that self-capping of the pilin-interactive interfaces is not a mechanism that is conservedly applied by all periplasmic chaperones, but is rather a case-specific solution to cap aggregation-prone surfaces. PMID:19390146

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