Science.gov

Sample records for research 1986-1999 progress

  1. Cle Elum Lake Anadromous Salmon Restoration Feasibility Study: Summary of Research, 1986-1999 Progress Report.

    SciTech Connect

    Dey, Douglas

    2000-04-01

    The focus of this research was to study the feasibility for anadromous salmonids to recolonize the habitat above reservoirs in the Yakima River without disruption to irrigation withdrawals. A primary concern was whether anadromous fish could successfully exit reservoirs and survive downstream passage through the Yakima and Columbia Rivers to the ocean.

  2. Photovoltaic concentrator research progress

    SciTech Connect

    Arvizu, D.E.

    1985-01-01

    This paper provides a review of progress in the DOE sponsored, Sandia managed Photovoltaic Concentrator Research Project. Research status, project goals and a discussion of concentrator economics is presented. Recent research accomplishments that will be discussed include 21% efficient baseline silicon cells by Applied Solar Energy Corporation and Sandia, 26% efficient GaAs cells by Varian Associates, and near 25% mechanically stacked multijunction GaAs/Si cells by Hughes Research, Applied Solar, and Sandia. In addition, improvements in breadboard module units (i.e. single lens/cell combination) such as a 19% GaAs unit by Varian and a near 17% silicon unit by ENTECH will be reviewed. This paper concludes that the photovoltaic concentrator option is making excellent progress toward competitive cost-effectiveness and provides a strong photovoltaic alternative.

  3. Progress in palaeotsunami research

    NASA Astrophysics Data System (ADS)

    Goff, James; Chagué-Goff, Catherine; Nichol, Scott; Jaffe, Bruce; Dominey-Howes, Dale

    2012-01-01

    The study of palaeotsunamis preserved in the sedimentary record has developed over the past three decades to a point where the criteria used to identify these events range from well-tested and accepted to new methods yet to receive wide application. In this paper we review progress with the development of these criteria and identify opportunities for refinements and for extending their application to new settings. The emphasis here is on promoting the use of multiple proxies, selected to best match the context of the site or region of interest. Ultimately, this requires that palaeotsunami research must be a multidisciplinary endeavour and indeed, extend beyond the geological sciences of sedimentology and stratigraphy and, to include knowledge and approaches from field such as archaeology, anthropology and sociology. We also argue that in some instances, despite the use of multiple proxies, the evidence for tsunami inundation of a coast simply may not be preserved.

  4. Recent progress in henipavirus research.

    PubMed

    Halpin, Kim; Mungall, Bruce A

    2007-09-01

    Following the discovery of two new paramyxoviruses in the 1990s, much effort has been placed on rapidly finding the reservoir hosts, characterising the genomes, identifying the viral receptors and formulating potential vaccines and therapeutic options for these viruses, Hendra and Nipah viruses caused zoonotic disease on a scale not seen before with other paramyxoviruses. Nipah virus particularly caused high morbidity and mortality in humans and high morbidity in pig populations in the first outbreak in Malaysia. Both viruses continue to pose a threat with sporadic outbreaks continuing into the 21st century. Experimental and surveillance studies identified that pteropus bats are the reservoir hosts. Research continues in an attempt to understand events that precipitated spillover of these viruses. Discovered on the cusp of the molecular technology revolution, much progress has been made in understanding these new viruses. This review endeavours to capture the depth and breadth of these recent advances. PMID:17629946

  5. Progress in photovoltaic concentrator research

    SciTech Connect

    Arvizu, D.E.

    1987-01-01

    This paper reviews the recent progress in photovoltaic concentrator research. In the past 18 months, several exciting new developments have been reported. Record efficiency concentrator silicon cells have been reported at Stanford University, with 28% efficient high resistivity cells, and at the University of New South Wales, with near 25% efficient low resistivity cells. Both groups also report record 22% one-sun efficiencies for these cells. Compound semiconductor cells have also made advances. Research on multijunction devices has led to a mechanically stacked concentrator cell with near 27% efficiency. Module improvements in commercial designs have taken the form of reduced cost and better component reliability. In addition, current research emphasis is on the development of new prototype modules that use the recent laboratory cell advances. Array efforts have centered around improving the tracking and control subsystems in accuracy, durability, and cost. Today, concentrator systems in high insolation areas are being offered at prices near $4/W/sub p/ ac for large MW sizes and at prices below those of flat plate systems ($8/W/sub p/) in hundred kW sizes. This paper will review these achievements and discuss the potential for concentrator technology to become a viable cost-effective bulk electrical power option.

  6. Progress in photovoltiac concentrator research

    SciTech Connect

    Arvizu, D.E.

    1986-10-01

    This paper reviews the recent progress in photovoltaic concentrator research. New record efficiency concentrator silicon cells have been reported at Stanford University, with 28% efficient high resistivity cells, and at the University of New South Wales, with near 25% efficient low resistivity cells. Both also report record 22% one-sun efficiencies. Compound semiconductor cells have also made advances. Research on multijunction devices has led to a mechanically stacked concentrator cell with near 27% efficiency. Module improvements have taken the form of reduced cost and better component reliability. In addition, a research emphasis is the development of new prototype modules that use the new laboratory cell advances. Array efforts have centered around improving the tracking and control subsystems in accuracy, durability, and cost. Today, concentrator systems in high insolation areas are being offered at prices near $4/W/sub p/ ac for large MW sizes and at prices below those of flat plate systems ($8/W/sub p/) in hundred kW sizes. This paper will review these achievements and discuss the potential for concentrator technology to become a viable cost-effective bulk electrical power option.

  7. Basic Research and Progress against Pediatric Cancer

    Cancer.gov

    An infographic about the importance of basic research for making progress against childhood cancers. The graphic shows the research milestones that led to the development and approval of Unituxin to treat neuroblastoma, a cancer seen mainly in children.

  8. Measuring research progress in photovoltaics

    NASA Technical Reports Server (NTRS)

    Jackson, B.; Mcguire, P.

    1986-01-01

    The role and some results of the project analysis and integration function in the Flat-plate Solar Array (FSA) Project are presented. Activities included supporting the decision-making process, preparation of plans for project direction, setting goals for project activities, measuring progress within the project, and the development and maintenance of analytical models.

  9. Progress in front propagation research

    NASA Astrophysics Data System (ADS)

    Fort, Joaquim; Pujol, Toni

    2008-08-01

    We review the progress in the field of front propagation in recent years. We survey many physical, biophysical and cross-disciplinary applications, including reduced-variable models of combustion flames, Reid's paradox of rapid forest range expansions, the European colonization of North America during the 19th century, the Neolithic transition in Europe from 13 000 to 5000 years ago, the description of subsistence boundaries, the formation of cultural boundaries, the spread of genetic mutations, theory and experiments on virus infections, models of cancer tumors, etc. Recent theoretical advances are unified in a single framework, encompassing very diverse systems such as those with biased random walks, distributed delays, sequential reaction and dispersion, cohabitation models, age structure and systems with several interacting species. Directions for future progress are outlined.

  10. Research Progress Report. Section I: Research Proposals.

    ERIC Educational Resources Information Center

    Peirce-Jones, John; And Others

    This document consists of seven research proposals for studies undertaken by the Child Development and Research Center at the University of Texas at Austin for 1967-68. Each of the proposals includes a discussion of the rationale, objective, basic design, sample population, data to be gathered, procedure or instruments to be used, relationships of…

  11. Progress In Electromagnetics Research Symposium (PIERS)

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The third Progress In Electromagnetics Research Symposium (PIERS) was held 12-16 Jul. 1993, at the Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California. More than 800 presentations were made, and those abstracts are included in this publication.

  12. [Research progress of small peptidomimetics].

    PubMed

    Wang, Jia; Sun, De-qun

    2015-08-01

    The study of peptide drugs has been an important direction in research and development of new drugs. However, lots of natural macromolecular peptides are limited in clinical use by their metabolic instability and low bioavailability. In recent years, the active small peptidomimetics open up a new hotspot of peptide drug development with the characteristics of low molecular weight, high bioactivity and structural modification. Many peptidomimetics are on the market or on the clinical study. This paper elaborated the small peptidomimetics approved by American Food and Drug Administration (FDA) from 2005 to 2014, and reviewed their researching status with source, synthetic method, chemical structure, marketing time, indication, clinical efficacy and safety. Research prospects in this field were discussed. PMID:26668991

  13. Private Pay Progression. Research Brief. Edition 6

    ERIC Educational Resources Information Center

    Anders, Jake

    2015-01-01

    While the issue of access to the professions is relatively well understood, there is limited understanding of the impact of entrants' backgrounds on success once in graduate employment. The research looks at the way social background continues to influence graduate pay and career progression once in professional employment. Key findings include:…

  14. [Research progress of rectoanal inhibitory reflex].

    PubMed

    Yin, Shuhui; Zhao, Ke

    2015-12-01

    The understanding of rectoanal inhibitory reflex (RAIR) is progressing for the latest 100 years. From the discovery of its important role in diagnosis of Hirschsprung's disease to all aspects of its development, reflex pathways, neural regulation and physiological functions, there have been more in-depth explorations. It is now recognized that a number of other diseases also have a more specific performance of RAIR. It has become an important and indispensable part to anorectal manometry. Research progress of rectoanal inhibitory reflex is reviewed in this article. PMID:26704013

  15. Occupational injury prevention research: progress and priorities.

    PubMed

    Stout, N A; Linn, H I

    2002-12-01

    The twentieth century witnessed remarkable reductions in the number and rate of occupational fatalities and injuries. However, many preventable injuries and deaths still occur. Barriers to progress in occupational injury prevention are discussed, along with strategies for overcoming them. In mining, the frequency of death has dramatically declined over the century. The latest figures from the BLS indicate that less than 6000 worker deaths from injury occurred in 2000. Catastrophic events have prompted increased attention, resources, and action on workplace hazards and risks, resulting in sweeping changes, including new protective laws. Science based approaches to prevention have contributed to progress. Multidisciplinary collaboration among injury prevention researchers, and collaboration and cooperation among multiple sectors, have improved the relevance and application of injury prevention research and development. Barriers to further progress include lack of evaluation of the effectiveness of prevention strategies and technologies, including cost effectiveness; lack of widespread implementation of known, effective prevention; and lack of efficient transfer and implementation of prevention knowledge and products to the workplace. Evaluation and implementation of prevention efforts are most successfully achieved in partnership between researchers and the industry at risk, which requires outreach efforts on the part of the occupational research community. PMID:12460949

  16. Teacher stress research: problems and progress.

    PubMed

    Pithers, R T

    1995-12-01

    There is a reasonably large body of published research evidence available which indicates that teaching is a 'highly' or 'extremely highly' stressful occupation for up to one-third of its professionals. Generalisations such as this one, however, are wrought with problems. These problems, for instance, range from confusion about the definition of stress through to how it is to be measured. They include methodological problems inherent in some of the research used to examine the area of teacher stress and as well include, for example, confusion about the effect of mediating variables in the production of stress and strain. This paper examines some of the more important pervasive research problems in current research on teacher stress and makes some suggestions for research progress. PMID:8580045

  17. Progress in research on Tourette syndrome

    PubMed Central

    Black, Kevin J.; Jankovic, Joseph; Hershey, Tamara; McNaught, Kevin St. P.; Mink, Jonathan W.; Walkup, John

    2014-01-01

    Tourette syndrome (TS) is a heritable neuropsychiatric disorder commonly complicated by obsessions and compulsions, but defined by frequent unwanted movements (motor tics) and vocalizations (phonic tics) that develop in childhood or adolescence. In recent years, research on TS has progressed rapidly on several fronts. Inspired by the Fifth International Scientific Symposium on Tourette Syndrome, the articles in this special issue review advances in the phenomenology, epidemiology, genetics, pathophysiology, and treatment of TS. PMID:25436182

  18. [Clinical research progress in infantile nystagmus syndrome].

    PubMed

    Zong, Yao; Wang, Li-hua

    2013-07-01

    Infantile nystagmus syndrome (INS) is an ocular motor disorder that presents at birth or early infancy. It is clinically characterized by involuntary and conjugated oscillation of the eyes, which often causes several complications such as amblyopia, lateral view, strabismus and torticollis. The etiology of INS is not fully understood, and this disease cannot be cured completely. This paper reviews the progress of research on the concept, etiology and pathogenesis, clinical manifestations, common examination methods, diagnosis and treatment of INS. PMID:24257363

  19. Research progress on the Kelly game

    NASA Astrophysics Data System (ADS)

    Zhang, Liang

    2010-08-01

    The growth-optimal portfolio optimization strategy has been investigated in many ways since firstly pioneered by Kelly. This paper firstly introduces the research progress of this so-called Kelly game. Based on the original Kelly game the optimality is shortly proofed. Especially generalized research is introduced such as the relation between M-V approach and the Kelly approach, the question of diversification, the influence of transaction fees and limited information, etc. Then the application of Kelly strategy is discussed with some conclusions.

  20. [Progress on the research of lactose intolerance].

    PubMed

    Chen, J; Sai, X Y

    2016-02-01

    Our group generalized the research development of lactose intolerance, both internationally and nationally. We systematically reviewed the pathogenesis, genetic polymorphisms of lactase deficiency, relevant progress of diagnostic methods and treatment. Through this systematic review, we undedrstood that there were insufficient research efforts made on understanding the epidemiological feature of lactose intolerance in this country. Relevant genetic mutations of people were also not clear, neither the development of simple and effective diagnosis method made. We should continue to extensively and deeply carry out the study regarding methods for early prevention and intervention on lactose intolerance. PMID:26917535

  1. Progress in Malassezia Research in Korea

    PubMed Central

    Kim, Soo Young; Lee, Yang Won; Choe, Yong Beom

    2015-01-01

    Yeasts of the genus Malassezia are part of the normal flora of human skin. However, they are also associated with various skin diseases. Since the introduction of Malassezia to the Korean Dermatologic Society two decades ago, remarkable progress has been made in our knowledge of this genus. In this paper, we review recent developments in Malassezia research, including taxonomy and methods for species identification, recent genome analyses, Malassezia species distribution in healthy conditions and in specific skin diseases, trials investigating the mechanisms underlying Malassezia-related diseases, as well as therapeutic options. This review will enhance our understanding of Malassezia yeasts and related skin diseases in Korea. PMID:26719632

  2. Research Progress and Accomplishments on ISS

    NASA Astrophysics Data System (ADS)

    Uri, John J.

    2002-01-01

    The first research payloads reached the International Space Station (ISS) more than two years ago, with research operating continuously since March 2001. Seven research racks are currently on-orbit, with three more arriving soon to expand science capabilities. Through the first five expeditions, more than 60 unique NASA-managed investigations from 11 nations have been supported, and several are continuing into later missions. More than 70,000 experiment-hours have been completed, employing more than 800 hours of crew time. These numbers are growing daily. The multidisciplinary program includes research in life sciences, physical sciences, biotechnology, Earth sciences, technology demonstrations, as well as commercial endeavors and educational activities. The Payload Operations and Integration Center monitors the onboard activities around the clock, working with numerous Principal Investigators and Payload Developers at their remote sites. Future years will see expansion of the station with research modules provided by Japan and the European Space Agency, which will be outfitted with additional research racks. This paper summarizes the amazing progress made so far.

  3. Recent Progress on Spherical Torus Research

    SciTech Connect

    Ono, Masayuki; Kaita, Robert

    2014-01-01

    The spherical torus or spherical tokamak (ST) is a member of the tokamak family with its aspect ratio (A = R0/a) reduced to A ~ 1.5, well below the normal tokamak operating range of A ≥ 2.5. As the aspect ratio is reduced, the ideal tokamak beta β (radio of plasma to magnetic pressure) stability limit increases rapidly, approximately as β ~ 1/A. The plasma current it can sustain for a given edge safety factor q-95 also increases rapidly. Because of the above, as well as the natural elongation κ, which makes its plasma shape appear spherical, the ST configuration can yield exceptionally high tokamak performance in a compact geometry. Due to its compactness and high performance, the ST configuration has various near term applications, including a compact fusion neutron source with low tritium consumption, in addition to its longer term goal of attractive fusion energy power source. Since the start of the two megaampere class ST facilities in 2000, National Spherical Torus Experiment (NSTX) in the US and Mega Ampere Spherical Tokamak (MAST) in UK, active ST research has been conducted worldwide. More than sixteen ST research facilities operating during this period have achieved remarkable advances in all of fusion science areas, involving fundamental fusion energy science as well as innovation. These results suggest exciting future prospects for ST research both near term and longer term. The present paper reviews the scientific progress made by the worldwide ST research community during this new mega-ampere-ST era.

  4. Progress in plant research in space

    NASA Technical Reports Server (NTRS)

    Dutcher, F. Ronald; Hess, Elizabeth L.; Halstead, Thora W.

    1994-01-01

    Progress is reviewed of spaceflight research conducted with plants between 1987 and 1992. Numerous plant experiments have been performed on spacecraft and sounding rockets in the past five years by scientists of the US, the former Soviet Union, Europe, and other areas. The experiments are categorized into three areas: gravity sensing, transduction, and response; development and reproduction; and metabolism, photosynthesis, and transport. The results of these experiments continue to demonstrate that gravity and/or other factors of spaceflight affect plants at the organismal, cellular, subcellular, and molecular levels, resulting in changes in orientation, development, metabolism, and growth. The challenge now is to truly dissect the effects of gravity from those of other spaceflight factors and to identify the basic mechanisms underlying gravity's effects.

  5. Antimatter Matters: Progress in Cold Antihydrogen Research

    NASA Astrophysics Data System (ADS)

    Yamazaki, Yasunori

    2012-11-01

    The purpose of cold antihydrogen research is briefly reviewed together with the latest developments of manipulating antihydrogen atoms. Two major progresses last year were the trapping of antihydrogen atoms in a magnetic bottle and synthesis of antihydrogen atoms in a cusp trap, where a spin-polarized antihydrogen beam can be extracted as an intensified beam. The magnetic bottle consists of an octupole coil and a pair of mirror coils, which improved the magnetic field uniformity near the axis, and so the stability of trapping antiprotons and positrons. Eventually, antihydrogen atoms were trapped for more than 1000s, which is ready to be testified with high precision laser spectroscopy. The cusp trap consists of a superconducting anti-Helmholtz coil and a stack of multiple ring electrodes. This success opens a new path to make a stringent test of the CPT symmetry via high precision microwave spectroscopy of ground-state hyperfine transitions of antihydrogen atoms.

  6. Recent progress on spherical torus research

    SciTech Connect

    Ono, Masayuki; Kaita, Robert

    2015-04-15

    The spherical torus or spherical tokamak (ST) is a member of the tokamak family with its aspect ratio (A = R{sub 0}/a) reduced to A ∼ 1.5, well below the normal tokamak operating range of A ≥ 2.5. As the aspect ratio is reduced, the ideal tokamak beta β (radio of plasma to magnetic pressure) stability limit increases rapidly, approximately as β ∼ 1/A. The plasma current it can sustain for a given edge safety factor q-95 also increases rapidly. Because of the above, as well as the natural elongation κ, which makes its plasma shape appear spherical, the ST configuration can yield exceptionally high tokamak performance in a compact geometry. Due to its compactness and high performance, the ST configuration has various near term applications, including a compact fusion neutron source with low tritium consumption, in addition to its longer term goal of an attractive fusion energy power source. Since the start of the two mega-ampere class ST facilities in 2000, the National Spherical Torus Experiment in the United States and Mega Ampere Spherical Tokamak in UK, active ST research has been conducted worldwide. More than 16 ST research facilities operating during this period have achieved remarkable advances in all fusion science areas, involving fundamental fusion energy science as well as innovation. These results suggest exciting future prospects for ST research both near term and longer term. The present paper reviews the scientific progress made by the worldwide ST research community during this new mega-ampere-ST era.

  7. Recent progress on spherical torus research

    NASA Astrophysics Data System (ADS)

    Ono, Masayuki; Kaita, Robert

    2015-04-01

    The spherical torus or spherical tokamak (ST) is a member of the tokamak family with its aspect ratio (A = R0/a) reduced to A ˜ 1.5, well below the normal tokamak operating range of A ≥ 2.5. As the aspect ratio is reduced, the ideal tokamak beta β (radio of plasma to magnetic pressure) stability limit increases rapidly, approximately as β ˜ 1/A. The plasma current it can sustain for a given edge safety factor q-95 also increases rapidly. Because of the above, as well as the natural elongation κ, which makes its plasma shape appear spherical, the ST configuration can yield exceptionally high tokamak performance in a compact geometry. Due to its compactness and high performance, the ST configuration has various near term applications, including a compact fusion neutron source with low tritium consumption, in addition to its longer term goal of an attractive fusion energy power source. Since the start of the two mega-ampere class ST facilities in 2000, the National Spherical Torus Experiment in the United States and Mega Ampere Spherical Tokamak in UK, active ST research has been conducted worldwide. More than 16 ST research facilities operating during this period have achieved remarkable advances in all fusion science areas, involving fundamental fusion energy science as well as innovation. These results suggest exciting future prospects for ST research both near term and longer term. The present paper reviews the scientific progress made by the worldwide ST research community during this new mega-ampere-ST era.

  8. Experimental Research Progress of the VASIMR Engine

    NASA Astrophysics Data System (ADS)

    Squire, J. P.; Díaz, F. R. Chang; Jacobson, V. T.; McCaskill, G. E.; Winter, D. S.

    2002-01-01

    The Advanced Space Propulsion Laboratory (ASPL) of NASA's Johnson Space Center is performing research on a Variable Specific Impulse MagnetoPlasma Rocket (VASIMR). The VASIMR is a high power, radio frequency (RF) driven magnetoplasma rocket, capable of very high exhaust velocities, > 100 km/s. In addition, its unique architecture allows in- flight mission-optimization of thrust and specific impulse to enhance performance and reduce trip time. A NASA-led research team involving industry, academia and government facilities is pursuing the development of this concept in the United States. The ASPL's experimental research focuses on three major areas: helicon plasma production, ion cyclotron resonant acceleration (ICRA) and plasma expansion in a magnetic nozzle. The VASIMR experiment (VX-10) performs experimental research that demonstrates the thruster concept at a total RF power on the order of 10 kW. A flexible four- magnet system, with a 1.3 Tesla maximum magnetic field strength, is computer controlled to study axial magnetic field profile shape effects. Power generated at 10 - 50 MHz with about 5 kW is used to perform helicon plasma source development. A 3 MHz RF transmitter capable of 100 kW is available for ICRA experiments. The primary diagnostics are: gas mass flow controllers, RF input power, Langmuir probes, Mach probe, retarding potential analyzers (RPA), microwave interferometer, neutral pressure measurements and plasma light emission. In addition, many thermocouples are attached inside the vacuum chamber to measure heat loads around the plasma discharge. Helicon research so far has been done with hydrogen, deuterium, helium, nitrogen, argon, xenon and mixtures of these gases. Optimization studies have been performed with the magnetic field axial profile shape, gas flow rate, gas tube geometry and RF frequency. The highest performing discharges are found with a high magnetic field choke downstream of the helicon antenna. Upwards of a 40% gas utilization is

  9. Research progress in China's Lop Nur

    NASA Astrophysics Data System (ADS)

    Dong, Zhibao; Lv, Ping; Qian, Guangqiang; Xia, Xuncheng; Zhao, Yuanje; Mu, Guijin

    2012-02-01

    China's Lop Nur is one of the world's largest playas, and is located in the driest part of Central Asia. Scientific explorations by Chinese and foreign researchers have been continuously conducted there since the mid- to late 1800 s, and much progress has been made, but many issues remain hotly debated. Particularly intense debate focuses on the formation, environmental evolution, drying date of the Lop Nur lake, and cause of the helical salt crusts recently revealed by remote-sensing images. In this paper, we review the status of this research to provide insights that can inform studies in other arid zones that resemble the Lop Nur. The Lop Nur depression is a secondary unit of the Tarim Block, controlled by faults and fractures formed by the Himalayan orogeny, but various competing explanations have been proposed for how these geological structures gave rise to the depression. The depression's formation date also remains unclear. Several boreholes have been created to reconstruct the environmental evolution at different time scales since the Quaternary, and deposition rates of lake sediments, especially since the Late Pleistocene, have averaged less than 1 mm annually. The drying date of the Lop Nur lake is also debated. The helical salt crust structures appear to have formed as the lake shrank, but how and when they formed is unclear. Huge potash reserves have been found, and large-scale potash fertilizer production has begun, but the origin of these deposits is debated. Understanding the factors causing environmental evolution in this region is a central issue that will help us to clarify these and other debated issues.

  10. Federal Government Research in Progress: Information for Science and Technology.

    ERIC Educational Resources Information Center

    Robinson, Judith Schiek; Aluri, Rao

    1983-01-01

    Offers overview of research in progress information systems which provide information on projects between inception and published reports, discussing demise of Smithsonian Science Information Exchange (SSIE), and efforts of National Technical Information Service to maintain SSIE files. A listing of 28 research in progress information systems and…

  11. RESEARCH IN INTERNATIONAL EDUCATION--RESEARCH IN PROGRESS AND RESEARCH RECENTLY COMPLETED, 1966-67 SURVEY.

    ERIC Educational Resources Information Center

    DAVIS, DOLORES; GIACALONE, CAROLYN

    THIS REPORT DESCRIBES RESEARCH STUDIES IN INTERNATIONAL EDUCATION--BOTH RESEARCH IN PROGRESS AND RESEARCH RECENTLY COMPLETED. INCLUDED ARE (1) THE AUTHORS' NAMES AND ADDRESSES, (2) A SUMMARY OF THE PURPOSE, SCOPE, METHOD, AND MAJOR FINDINGS OF STUDY, AND (4) THE ADDRESSES FROM WHICH COPIES MAY BE SECURED. THE CONTENTS ARE DIVIDED INTO 13 BROAD…

  12. Indian Institute of Geomagnetism: Progress in research

    NASA Astrophysics Data System (ADS)

    Progress and aspects is the study of the geomagnetic variations in the Indian region on quiet and disturbed days, equatorial electrojet field, electromagnetic induction in the earth, magnetic pulsations, aeronomy, radio scintillations, magnetosphere and solar wind, and solar-terrestrial relationships were reported.

  13. Progress in magnetic fusion energy research

    NASA Astrophysics Data System (ADS)

    Thomassen, Keith I.

    1993-03-01

    Remarkable scientific progress has been made in the Magnetic Fusion Energy Program since its inception 40 years ago. A key energy confinement parameter reflecting that progress has been improved 10,000,000-fold in that time. A formalized international collaborative effort of design and development for a 1000-MW experimental reactor (ITER) has been entered into by the United States, Russia, Japan, and the European Community. In the United States, a national project to build a superconducting steady-state advanced tokamak (SSAT) to improve the reactor prospects of fusion is underway. (The device has been newly renamed the Tokamak Physics Experiment.) Despite this very encouraging progress, the outlook for fusion as an energy source remains unclear, with both economic and technological attractiveness yet to be determined. However, with only limited options for long-term energy supplies, and with environmental consequences yet to play a more dominant role in our choices, the world can ill afford not to develop the potential of fusion in the decades to come.

  14. [Progress in epigenetic research on Alzheimer disease].

    PubMed

    Yang, Nannan; Wei, Yang; Xu, Qian; Tang, Beisha

    2016-04-01

    Alzheimer's disease (AD) is the most common neurodegenerative disorder, which features mainly with memory impairment as the initial symptom of progressive loss of cognitive function. Its main pathological changes include senile plaques and neurofibrillary tangles. The pathogenesis of AD is still unclear, though it may be connected with aging, genetic factors and environmental factors. Among these, aging and environmental factors can be modified by epigenetics. In this paper, advances in the study of epigenetic mechanisms related to the pathogenesis of AD are reviewed. PMID:27060329

  15. Progress and pitfalls in Shigella vaccine research

    PubMed Central

    Barry, Eileen M.; Pasetti, Marcela F.; Sztein, Marcelo B.; Fasano, Alessio; Kotloff, Karen L.; Levine, Myron M.

    2013-01-01

    Renewed awareness of the significant morbidity and mortality that Shigella causes among young children in developing countries combined with technological innovations in vaccinology has led to the development of novel vaccine strategies in the past five years. Along with advancement of classical vaccines in clinical trials and new sophisticated measurements of immunological responses, much new data has been produced lending promise to the potential for production of safe and effective Shigella vaccines. Herein we review the recent progress in Shigella vaccine development within the framework of persistent obstacles. PMID:23419287

  16. [The eosinophilic otitis media's research progress].

    PubMed

    Liu, Yang; Zhang, Zhiyuan

    2015-09-01

    The eosinophilic otitis media(EOM) is an intractable disease characterized by the presence of a highly viscous yellow effusion with extensive accumulation of eosinophils in the middle ear; granulation tissue can been discovered in the middle ear cavity; most of patients have association with bronchial asthma; resist to conventional treatment for otitis media; EOM patients show gradual deterioration of hearing and sometimes become deaf suddenly; effective treatment involves use of topical and oral steroids. This article summarizes the progress of the EOM's diagnosis and treatment. PMID:26647553

  17. Technical Seminar: "Progress in Aircraft Noise Research"""

    NASA Video Gallery

    Advances in aircraft noise research can be attributed to the development of new technologies and sustained collaboration with industry, universities and government organizations. Emphasis has been ...

  18. Research Progress and Accomplishments on ISS

    NASA Technical Reports Server (NTRS)

    Roe, Lesa B.; Uri, John J.

    2002-01-01

    The first research payloads reached the International Space Station (ISS) more than two years ago, with research operating continuously since March 2001. Seven research racks are currently on-orbit, with three more arriving soon to expand science capabilities. Through the first five expeditions, 60 unique NASA-managed investigations from 11 nations have been supported, many continuing into later missions. More than 90,000 experiment hours have been completed, and more than 1,000 hours of crew time have been dedicated to research, numbers that grow daily. The multidisciplinary program includes research in life sciences, physical sciences, biotechnology, Earth sciences, technology demonstrations as well as commercial endeavors and educational activities. The Payload Operations and Integration Center monitors the onboard activities around the clock, working with numerous Principal Investigators and Payload Developers at their remote sites. Future years will see expansion of the station with research modules provided by the European Space Agency and Japan, which will be outfitted with additional research racks. The first research payloads arrived at ISS more than two years ago, and continuous science has been ongoing for more than one and a half years. During this time, the research capabilities have been tremendously increased, even as assembly of the overall platform continues. Despite significant challenges along the way, ISS continues to successfully support a large number of investigations in a variety of research disciplines. The results of some of the early investigations are reaching the publication stage. The near future looms with new challenges, but experience to date and dedicated efforts give reason to be optimistic that the challenges will be overcome and that new and greater successes will be added to past ones.

  19. Measuring Math Growth: Implications for Progress Monitoring. Research Brief 5

    ERIC Educational Resources Information Center

    Alonzo, Julie; Irvin, P. Shawn

    2013-01-01

    Achievement growth in math is often framed in the context of monitoring student progress within a Response to Intervention (RTI) approach to teaching and learning. In this research brief we report on a study that examined initial status and within-year growth for fourth grade students who received short progress-monitoring assessments in math…

  20. [Otolith microchemistry of tuna species: research progress].

    PubMed

    Zhu, Guo-ping

    2011-08-01

    Microchemistry analysis of trace elements and isotopes in fishes' calcified substances is an emerging approach to analyze the population structure, life history, and migration environmental history of fishes. With the increasing improvement of the researches and applications of otolith microchemistry, this approach has been a good tool for studying the ecology of tuna species. Currently, the research contents of tuna species' otolith microchemistry mainly include trace elements and isotopes, and the former is the emphasis and hotspot in applied research, playing a vital role in the researches of population partitioning, natal origin, migration environmental history, and life history of tuna species, especially bluefin tuna. However, most of the researches are focusing on the variation of otolith's Sr/Ca ratio, and there is no final conclusion on the relationships between the fractionation of isotopes C and O in otolith and the temperature. For the sake of exploiting the huge value of otolith microchemistry, it would be necessary to strengthen the researches on the deposition mechanisms of trace elements in otolith, and to analyze the spatio-temporal variations of various trace elements in otolith by comprehensive research methods. PMID:22097389

  1. [Recent researching progress of Lepidium meyenii (Maca)].

    PubMed

    Zhou, Yan-yan; Zhao, Hai-yu; Si, Nan; Wang, Hong-jie; Gian, Bao-lin

    2015-12-01

    Maca as one of the star products in the international health care market in recent years, had a wide range of application value and promoted to all over the world. However, the basic research of Maca was not deep, lack of systematic and clear efficacy studies. Market products hype its aphrodisiac effect, which greatly impact more systematic in-depth research and exploration. Therefore, this paper briefly summarizes advance research in recent years including the status quo of the resources, growth cultivation, phytochemical, pharmacological effect and other aspects, which can provide reference for rational development and utilization of Maca. PMID:27141658

  2. X-48B Flight Research Progress Overview

    NASA Technical Reports Server (NTRS)

    Risch, Timothy K.

    2008-01-01

    This viewgraph presentation gives a general overview of the X-48B Flight research program. Major program accomplishments, a detailed description of the X-48B vehicle, along with flight tests, and wind tunnel tests are also described.

  3. Summary of research in progress at ICASE

    NASA Technical Reports Server (NTRS)

    1993-01-01

    This report summarizes research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, fluid mechanics, and computer science during the period October 1, 1992 through March 31, 1993.

  4. Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS

    PubMed Central

    Thompson, Alan; Baker, David; Baneke, Peer; Brown, Doug; Browne, Paul; Chandraratna, Dhia; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Feinstein, Anthony; Kapoor, Raj; Lee, Karen; Salvetti, Marco; Sharrock, Kersten; Toosy, Ahmed; Zaratin, Paola; Zuidwijk, Kim

    2012-01-01

    Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS. PMID:22917690

  5. Setting a research agenda for progressive multiple sclerosis: the International Collaborative on Progressive MS.

    PubMed

    Fox, Robert J; Thompson, Alan; Baker, David; Baneke, Peer; Brown, Doug; Browne, Paul; Chandraratna, Dhia; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Feinstein, Anthony; Kapoor, Raj; Lee, Karen; Salvetti, Marco; Sharrock, Kersten; Toosy, Ahmed; Zaratin, Paola; Zuidwijk, Kim

    2012-11-01

    Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS. PMID:22917690

  6. Research Finds Link Between Statin Use and Progressive Muscle Disease

    MedlinePlus

    ... Research Finds Link Between Statin Use and Progressive Muscle Disease Each year, millions of Americans take statins, ... people these benefits come at a cost: widespread muscle pain that persists as long as the drugs ...

  7. Molecular imaging promotes progress in orthopedic research.

    PubMed

    Mayer-Kuckuk, Philipp; Boskey, Adele L

    2006-11-01

    Modern orthopedic research is directed towards the understanding of molecular mechanisms that determine development, maintenance and health of musculoskeletal tissues. In recent years, many genetic and proteomic discoveries have been made which necessitate investigation under physiological conditions in intact, living tissues. Molecular imaging can meet this demand and is, in fact, the only strategy currently available for noninvasive, quantitative, real-time biology studies in living subjects. In this review, techniques of molecular imaging are summarized, and applications to bone and joint biology are presented. The imaging modality most frequently used in the past was optical imaging, particularly bioluminescence and near-infrared fluorescence imaging. Alternate technologies including nuclear and magnetic resonance imaging were also employed. Orthopedic researchers have applied molecular imaging to murine models including transgenic mice to monitor gene expression, protein degradation, cell migration and cell death. Within the bone compartment, osteoblasts and their stem cells have been investigated, and the organic and mineral bone phases have been assessed. These studies addressed malignancy and injury as well as repair, including fracture healing and cell/gene therapy for skeletal defects. In the joints, molecular imaging has focused on the inflammatory and tissue destructive processes that cause arthritis. As described in this review, the feasibility of applying molecular imaging to numerous areas of orthopedic research has been demonstrated and will likely result in an increase in research dedicated to this powerful strategy. Molecular imaging holds great promise in the future for preclinical orthopedic research as well as next-generation clinical musculoskeletal diagnostics. PMID:16843078

  8. Recent Progress in the Superconductivity Research Field

    NASA Astrophysics Data System (ADS)

    Ichinose, Ataru

    Major developments in the research field of superconductivity have been achieved in 2008. Since the discovery of high-Tc superconductors, their practical application has been studied by many researchers. Coated conductors consisting of an YBa2Cu3Oy superconducting layer deposited on metal tapes buffered oxide layers were developed in the NEDO project between FY2003 and FY2007. These technologies for coated conductors are expected to be applicable to electrical power equipment. A new NEDO project that started in FY2008 is focusing on the development of superconducting electric power equipment such as power cables, superconducting magnetic energy storage devices (SMES) and transformers. Furthermore, a new family of high-Tc superconductors, Fe-As-O-based superconductors, has been discovered. The highest reported critical temperature, Tc, has rapidly increased owing to the considerable effort of many researchers. A new social environment based on superconductivity technology might indeed be realized in the near future.

  9. Recent progress in snow and ice research

    SciTech Connect

    Richter-menge, J.A.; Colbeck, S.C.; Jezek, K.C. )

    1991-01-01

    A review of snow and ice research in 1987-1990 is presented, focusing on the effects of layers in seasonal snow covers, ice mechanics on fresh water and sea ice, and remote sensig of polar ice sheets. These topics provide useful examples of general needs in snow and ice research applicable to most areas, such as better representation in models of detailed processes, controlled laboratory experiments to quantify processes, and field studies to provide the appropriate context for interpretation of processes from remote sensing.

  10. Recent Progress in Aircraft Noise Research

    NASA Technical Reports Server (NTRS)

    Envia, Edmane; Thomas, Russell

    2007-01-01

    An overview of the acoustics research at NASA under the Subsonic Fixed Wing project is given. The presentation describes the rationale behind the noise reduction goals of the project in the context of the next generation air transportation system, and the emphasis placed on achieving these goals through a combination of the in-house and collaborative efforts with industry, universities and other government agencies. The presentation also describes the in-house research plan which is focused on the development of advanced noise and flow diagnostic techniques, next generation noise prediction tools, and novel noise reduction techniques that are applicable across a wide range of aircraft.

  11. Progress in rotor broadband noise research

    NASA Technical Reports Server (NTRS)

    Brooks, T. F.; Schlinker, R. H.

    1983-01-01

    The current status of research on various rotor broadband noise sources is reviewed. Theoretical modeling techniques which appear to have the most promise in the development of successful noise prediction capabilities are emphasized. The types of noise considered include: turbulence ingestion noise, blade self-noise due to turbulence passing the trailing edge, blade self-noise due to separated flow, and blade self-noise due to vortex shedding. Comparisons with experimental results are given, and present theoretical and experimental limitations are delineated to help identify areas of needed research.

  12. Progress in indium phosphide solar cell research

    NASA Technical Reports Server (NTRS)

    Weinberg, Irving; Swartz, Clifford K.; Hart, R. E., Jr.

    1989-01-01

    Progress, dating from the start of the Lewis program, is reviewed emphasizing processing techniques which have achieved the highest efficiencies in a given year. To date, the most significant achievement has been attainment of AM0 total area efficiencies approaching 19 percent. Although closed tube diffusion is not considered to be an optimum process, reasonably efficient 2cm x 2cm and 1cm x 2cm InP cells have been produced in quantity by this method with a satellite to be launched in 1990 using these cells. Proton irradiation of these relatively large area cells indicates radiation resistance comparable to that previously reported for smaller InP cells. A similar result is found for the initial proton irradiations of ITO/InP cells processed by D. C. sputtering. With respect to computer modelling, a comparison of n/p homojunction InP and GaAs cells of identical geometries and dopant concentrations has confirmed the superior radiation resistance of InP cells under 1 MeV electron irradiations.

  13. Nuclear structure research. Annual progress report

    SciTech Connect

    Wood, J.L.

    1993-10-31

    The most significant development this year has been the successful elucidation of the low-energy systematics of the very neutron-deficient Pr, Nd, Pm, and Sm isotopes. This includes an extensive set of Nilsson bandheads in {sup 133}Nd. Some serious errors in earlier decay scheme work were found. The results require some significant reassessments of mean-field calculations in this region. Part of our program continues to focus on shape coexistence and electric monopole (E0) transitions in nuclei. Following the discovery of coexisting ``gamma`` bands connected by E0 transitions in {sup 184}Pt, a similar behavior in {sup 186}Pt was established from {sup 186}Au decay data. This includes a pure E0 transition between states with J{sup {pi}} = 3{sup +}, just as was seen in {sup 184}Pt. Progress has been made in elucidating the low-energy systematics of the neutron-deficient Ir isotopes. A search for the population of the superdeformed band in {sup 194}Pb in the decay of {sup 194}Bi was unsuccessful. An extensive program of systematics for nuclei at and near N = Z has been initiated.

  14. Progress in heavy ion fusion research

    NASA Astrophysics Data System (ADS)

    Celata, C. M.; Bieniosek, F. M.; Henestroza, E.; Kwan, J. W.; Lee, E. P.; Logan, G.; Prost, L.; Seidl, P. A.; Vay, J.-L.; Waldron, W. L.; Yu, S. S.; Barnard, J. J.; Callahan, D. A.; Cohen, R. H.; Friedman, A.; Grote, D. P.; Lund, S. M.; Molvik, A.; Sharp, W. M.; Westenskow, G.; Davidson, Ronald C.; Efthimion, Philip; Gilson, Erik; Grisham, L. R.; Kaganovich, Igor; Qin, Hong; Startsev, Edward A.; Bernal, S.; Cui, Y.; Feldman, D.; Godlove, T. F.; Haber, I.; Harris, J.; Kishek, R. A.; Li, H.; O'Shea, P. G.; Quinn, B.; Reiser, M.; Valfells, A.; Walter, M.; Zou, Y.; Rose, D. V.; Welch, D. R.

    2003-05-01

    The U.S. Heavy Ion Fusion program has recently commissioned several new experiments. In the High Current Experiment [P. A. Seidl et al., Laser Part. Beams 20, 435 (2003)], a single low-energy beam with driver-scale charge-per-unit-length and space-charge potential is being used to study the limits to transportable current posed by nonlinear fields and secondary atoms, ions, and electrons. The Neutralized Transport Experiment similarly employs a low-energy beam with driver-scale perveance to study final focus of high perveance beams and neutralization for transport in the target chamber. Other scaled experiments—the University of Maryland Electron Ring [P. G. O'Shea et al., accepted for publication in Laser Part. Beams] and the Paul Trap Simulator Experiment [R. C. Davidson, H. Qin, and G. Shvets, Phys. Plasmas 7, 1020 (2000)]—will provide fundamental physics results on processes with longer scale lengths. An experiment to test a new injector concept is also in the design stage. This paper will describe the goals and status of these experiments, as well as progress in theory and simulation. A proposed future proof-of-principle experiment, the Integrated Beam Experiment, will also be described.

  15. UCLA accelerator research & development. Progress report

    SciTech Connect

    1997-09-01

    This report discusses work on advanced accelerators and beam dynamics at ANL, BNL, SLAC, UCLA and Pulse Sciences Incorporated. Discussed in this report are the following concepts: Wakefield acceleration studies; plasma lens research; high gradient rf cavities and beam dynamics studies at the Brookhaven accelerator test facility; rf pulse compression development; and buncher systems for high gradient accelerator and relativistic klystron applications.

  16. Progress in research on chlorate candle technology

    NASA Technical Reports Server (NTRS)

    Littman, J.

    1970-01-01

    Research and development program improves sodium chlorate candle formulation, production method, and igniter design. Cobalt is used as the fuel, dry processing methods are used to lower the water content, and a device based on pyrotechnic heater concepts is used as the igniter.

  17. [Research progress of Mongolian medicine digeda].

    PubMed

    Zhang, Chun-Hong; Chensuyile; Zhang, Na; Long, Ping; Li, Zhen-Hua; Zhu, Hong; Wang, Zhen-Wang; Li, Min-Hui

    2013-12-01

    Traditional Mongolian medicine Digeda processes a significant importance in clinical therapy with notably actions of heat-clear and detoxication effects. This paper intends to provide comprehensive insight into the species textual research, chemical constituents, qualitative identification, pharmacology and clinical application of Mongolian medicine Digeda to provide valuable data for further studies and the development of clinical applications of these medicinal plants. PMID:24791546

  18. DISEASES OF CORALS: RESEARCH PROGRESS, REEF PROSPECTS

    EPA Science Inventory

    Scleractinian corals have been the subject of intensive research during the past few decades to improve understanding of their role in supporting diverse tropical and subtropical marine communities and to examine factors responsible for their decline and loss of community biodive...

  19. Research 1970/1971: Annual Progress Report.

    ERIC Educational Resources Information Center

    Georgia Inst. of Tech., Atlanta. Science Information Research Center.

    The report presents a summary of science information research activities of the School of Information and Computer Science, Georgia Institute of Technology. Included are project reports on interrelated studies in science information, information processing and systems design, automata and systems theories, and semiotics and linguistics. Also…

  20. Educational Design Research: Signs of Progress

    ERIC Educational Resources Information Center

    Reeves, Thomas C.

    2015-01-01

    This special issue of the "Australasian Journal of Educational Technology" includes an introductory article by the guest editors and six papers that illustrate the potential of educational design research (EDR) to address important problems in higher education. In this final paper, reflections on the papers are made. Then the rationale…

  1. Progress of research on water vapor lidar

    NASA Technical Reports Server (NTRS)

    Wilkerson, T. D.

    1990-01-01

    Research is described on several aspects of stimulated Raman scattering (SRS) of 532 nm laser light in H2, D2, and CH4. The goals of this work are to develop a more thorough understanding of nonlinear processes involving the Raman effect and four-wave mixing, and to find the best way to generate radiation at several wavelengths simultaneously, for lidar applications. Issues addressed are conversion efficiency, optimization of operating conditions (gas pressure, confocal parameter, etc.) and the distribution of output pulse energy over three Stokes components, the first anti-Stokes component, and the zeroth order (pump) wavelength. The described research and results constitute another step in the development of SRS applications for NASA's atmospheric lidar program.

  2. Office of Industrial Technologies research in progress

    SciTech Connect

    Not Available

    1993-05-01

    The US Department of Energy (DOE) Office of Industrial Technologies (OIT) conducts research and development activities which focus on improving energy efficiency and providing for fuel flexibility within US industry in the area of industrial conservation. The mission of OIT is to increase the utilization of existing energy-efficient equipment and to find and promote new, cost-effective ways for industrial facilities to improve their energy efficiency and minimize waste products. To ensure advancement of the technological leadership of the United States and to improve the competitiveness of American industrial products in world markets, OIT works closely with industrial partners, the staffs of the national laboratories, and universities to identify research and development needs and to solve technological challenges. This report contains summaries of the currently active projects supported by the Office of Industrial Technologies.

  3. Biodiesel research progress 1992-1997

    SciTech Connect

    Tyson, K.S.

    1998-04-01

    The US Department of Energy (DOE) Office of Fuels Development began evaluating the potential of various alternative fuels, including biodiesel, as replacement fuels for traditional transportation fuels. Biodiesel is derived from a variety of biological materials from waste vegetable grease to soybean oil. This alkyl ester could be used as a replacement, blend, or additive to diesel fuel. This document is a comprehensive summary of relevant biodiesel and biodiesel-related research, development demonstration, and commercialization projects completed and/or started in the US between 1992 and 1997. It was designed for use as a reference tool to the evaluating biodiesel`s potential as a clean-burning alternative motor fuel. It encompasses, federally, academically, and privately funded projects. Research projects are presented under the following topical sections: Production; Fuel characteristics; Engine data; Regulatory and legislative activities; Commercialization activities; Economics and environment; and Outreach and education.

  4. Progress of research on water vapor lidar

    NASA Technical Reports Server (NTRS)

    Wilkerson, Thomas D.; Singh, U. N.

    1989-01-01

    Research is summarized on applications of stimulated Raman scattering (SRS) of laser light into near infrared wavelengths suitable for atmospheric monitoring. Issues addressed are conversion efficiency, spectral purity, optimization of operating conditions, and amplification techniques. A Raman cell was developed and built for the laboratory program, and is now available to NASA-Langley, either as a design or as a completed cell for laboratory or flight applications. The Raman cell has been approved for flight in NASA's DC-8 aircraft. The self-seeding SRS technique developed here is suggested as an essential improvement for tunable near-IR DIAL applications at wavelengths of order 1 micrometer or greater.

  5. [Research progress on wind erosion control].

    PubMed

    Yi, Xiao-Yong; Zhao, Ha-Lin; Li, Yu-Qiang

    2007-04-01

    Wind erosion is the main inducement and an important process of desertification, and also, a main environmental problem needed to be controlled in many countries and areas. Based on the formation mechanisms of wind erosion and some important research results, this paper reviewed the biological, chemical, and mechanical measures in wind erosion control, which could be applied individually or integrated together to decrease or prevent wind erosion. It was suggested that management should be strengthened to ensure a better effect in applying these measures to further improve ecological environment. PMID:17615892

  6. Research progress in dynamic security assessment

    SciTech Connect

    Not Available

    1982-12-01

    Areas discussed are power system modeling, state estimation, structure decomposition, state forecasting, clustering and security measure development. A detailed dynamic model of a multi-machine power system has been developed. A process state estimator was developed to estimate the long-term dynamic behavior of the power system. The algorithm is identical to the extended Kalman filter but has a modified process noise driving term. A two-stage structure estimation technique was proposed for identifying the power system network configuration. Two approaches to structure decomposition were investigated. A time-scale decomposition of the system equations, based on a singular perturbation approach, was evaluated using a detailed model of a generating system. Spatial decomposition was examined by applying an optimal network decomposition technique to a 39-bus test system. Stochastic approximation based approaches to estimator simplification were examined. Explicit expressions were obtained for the evolution of the first and second moments of the system state. Research into security measures proceeded in three directions. The first area involves viewing the security assessment problem as a hyperplane crossing problem for a stochastic process. The second approach examined the stability of an unforced linear system where the system coefficients are subject to future jumps. The third area of research has led to the formulation of a security measure suitable for on-line assessment of transient stability.

  7. High energy physics research. Technical progress report

    SciTech Connect

    Piroue, P.A.

    1992-10-01

    The goal of this research is to understand the fundamental constituents of matter and their interactions. At this time, the following activities are underway: e{sup {plus}}e{sup {minus}} interactions and Z{sup 0} physics at CERN; studies to upgrade the L3 detector at LHC; very high statistics charm physics at Fermilab; search for the H particle at BNL; search for the fifth force; rare kaon decay experiments at BNL; study of B-meson physics at hadron colliders; e{sup {plus}}e{sup {minus}} pair creation by light at SLAC; R&D related to SSC experiments and the GEM detector; and theoretical research in elementary particle physics and cosmology. The main additions to the activities described in detail in the original grant proposal are (1) an experiment at SLAC (E-144) to study strong-field QED effects in e-laser and {gamma}-laser collisions, and (2) a search for the H particle at BNL (E-188). The R&D efforts for the GEM detector have also considerably expanded. In this paper we give a brief status report for each activity currently under way.

  8. Progress in toroidal confinement and fusion research

    SciTech Connect

    Furth, H.P.

    1987-10-01

    During the past 30 years, the characteristic T/sub i/n tau/sub E/-value of toroidal-confinement experiments has advanced by more than seven orders of magnitude. Part of this advance has been due to an increase of gross machine parameters. Most of this advance has been due to an increase of gross machine parameters. Most of the advance is associated with improvements in the ''quality of plasma confinement.'' The combined evidence of spherator and tokamak research clarifies the role of magnetic-field geometry in determining confinement and points to the importance of shielding out plasma edge effects. A true physical understanding of anomalous transport remains to be achieved. 39 refs., 11 figs., 1 tab.

  9. [Research Progress in Norovirus Bioaccumulation in Shellfish].

    PubMed

    Zhou, Deqing; Su, Laijin; Zhao, Feng; Ma, Liping

    2015-05-01

    Noroviruses (NoVs) are one of the most important foodborne viral pathogens worldwide. Shellfish are the most common carriers of NoVs as they can concentrate and accumulate large amounts of the virus through filter feeding from seawater. Shellfish may selectively accumulate NoVs with different genotypes, and this bioaccumulation may depend on the season and location. Our previous studies found various histo-blood group antigens (HBGAs) in shellfish tissues. While HBGAs might be the main reason that NoVs are accumulated in shellfish, the detailed mechanism behind NoV concentration and bioaccumulation in shellfish is not clear. Here we review current research into NoV bioaccumulation, tissue distribution, seasonal variation, and binding mechanism in shellfish. This paper may provide insight into controlling NoV transmission and decreasing the risks associated with shellfish consumption. PMID:26470540

  10. [Research progress of fecal microbiota transplantation].

    PubMed

    Dai, Ting; Tang, Tongyu

    2015-07-01

    Intestinal microbial ecosystem is the most complex and the largest micro-ecosystem of the mammals. The use of antibiotics can lead to a lot of major changes of the flora, making the intestinal flora damaged and impacted, even developing Clostridium difficile infection. Fecal microbiota transplantation (FMT) as a special organ transplant therapy, which can rebuild the intestinal flora, has raised the clinical concerns. It has been used in the refractory Clostridium difficile, inflammatory bowel disease, irritable bowel syndrome, chronic fatigue syndrome, and some non-intestinal diseases related to the metabolic disorders. But this method of treatment has not become a normal treatment, and many clinicians and patients can not accept it. This paper reviews relevant literature in terms of origin, indications, mechanism, production process, current situation and future research, and provide a reference for the clinical application of the treatment of fecal microbiota transplantation. PMID:26211780

  11. Partnerships for progress in active living: from research to action

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The theme for the 2011 Active Living Research Annual Conference was "Partnerships for Progress in Active Living: From Research to Action." The rationale for this theme was simple: no person is an island. The theme recognizes that partnerships are essential to identify and implement solutions for co...

  12. Center for Research for Mothers and Children. 1988 Progress Report.

    ERIC Educational Resources Information Center

    National Inst. of Child Health and Human Development (NIH), Bethesda, MD. Center for Research for Mothers and Children.

    The 1988 Progress Report covers research activities of the five branches of the Center for Research for Mothers and Children of the National Institute of Child Health and Human Development. An introductory section briefly describes the Center, notes staff activities and Center sponsored conferences and workshops, and identifies highlights of…

  13. A Road Map for Learning Progressions Research in Geography

    ERIC Educational Resources Information Center

    Huynh, Niem Tu; Solem, Michael; Bednarz, Sarah Witham

    2015-01-01

    This article provides an overview of learning progressions (LP) and assesses the potential of this line of research to improve geography education. It presents the merits and limitations of three of the most common approaches used to conduct LP research and draws on one approach to propose a first draft of a LP on map reading and interpretation.…

  14. NCSX Construction Progress and Research Plans

    SciTech Connect

    Neilson, G. H.; Heitzenroeder, P.; Lyon, J.; Nelson, B.; Reiersen, W.; Zarnstorff, M.; Brooks, A.; Brown, T.; Cole, M.; Chrzanowski, J.; Fogarty, P.; Gettelfinger, G.; Goranson, P.; Raftopoulos, S.; Schmidt, J.; Stratton, B.; Simmons, R.; Strykowsky, R.; Viola, M.; Williams, M.; Williamson, D.

    2005-09-26

    Stellarators use 3D plasma and magnetic field shaping to produce a steady-state disruption-free magnetic confinement configuration. Compact stellarators have additional attractive properties — quasi-symmetric magnetic fields and low aspect ratio. The National Compact Stellarator Experiment (NCSX) is being constructed at the Princeton Plasma Physics Laboratory (PPPL) in partnership with the Oak Ridge National Laboratory (ORNL) to test the physics of a high-beta compact stellarator with a lowripple, tokamak-like magnetic configuration. The engineering challenges of NCSX stem from its complex geometry requirements. These issues are addressed in the construction project through manufacturing R&D and system engineering. As a result, the fabrication of the coil winding forms and vacuum vessel are proceeding in industry without significant technical issues, and preparations for winding the coils at PPPL are in place. Design integration, analysis, and dimensional control are functions provided by system engineering to ensure that the finished product will satisfy the physics requirements, especially accurate realization of the specified coil geometries. After completion of construction in 2009, a research program to test the expected physics benefits will start.

  15. DIII-D research program progress

    SciTech Connect

    Stambaugh, R.D.

    1990-11-01

    A summary of highlights of the research on the DIII-D tokamak in the last two years is given. At low q, toroidal beta ({beta}{sub T}) has reached 11%. At high q, {epsilon}{beta}{sub p} has reached 1.8. DIII-D data extending from one regime to the other show the beta limit is at least {beta}{sub T}(%) {ge} 3.5 I/aB (MA, m, T). Prospects for using H-mode in future devices have been enhanced. The discovery of negative edge electric fields and associated turbulence suppression have become part of an emerging theory of H-mode. Long pulse (10 second) H-mode with impurity control has been demonstrated. Radial sweeping of the divertor strike points and gas puffing under the X-point have lowered peak divertor plate heat fluxes a factor of 3 and 2 respectively. T{sub i} = 17 keV has been reached in a hot ion H-mode. Electron cyclotron current drive (ECCD) has produced up to 70 kA of driven current. Program elements now beginning are fast wave current drive (FWCD) and an advanced divertor program (ADP). 38 refs., 10 figs.

  16. Computational Approaches for Translational Clinical Research in Disease Progression

    PubMed Central

    McGuire, Mary F.; Iyengar, M. Sriram; Mercer, David W.

    2011-01-01

    Today, there is an ever-increasing amount of biological and clinical data available that could be used to enhance a systems-based understanding of disease progression through innovative computational analysis. In this paper we review a selection of published research regarding computational methodologies, primarily from systems biology, that support translational research from the molecular level to the bedside, with a focus on applications in trauma and critical care. Trauma is the leading cause of mortality in Americans under 45 years of age, and its rapid progression offers both opportunities and challenges for computational analysis of trends in molecular patterns associated with outcomes and therapeutic interventions. This review presents methods and domain-specific examples that may inspire the development of new algorithms and computational methods that utilize both molecular and clinical data for diagnosis, prognosis and therapy in disease progression. PMID:21712727

  17. Cold Fronts Research Programme: Progress, Future Plans, and Research Directions.

    NASA Astrophysics Data System (ADS)

    Ryan, B. F.; Wilson, K. J.; Garratt, J. R.; Smith, R. K.

    1985-09-01

    Following the analysis of data collected during Phases land II of the Cold Fronts Research Programme (CFRP) a conceptual model for the Australian summertime "cool change" has been proposed. The model provides a focus and a framework for the design of Phase III.The model is based on data gathered from a mesoscale network centered on Mount Gambier, South Australia, and includes the coastal waters to the west and relatively flat terrain to the east. The first objective of Phase III is to generalize the model so that it is applicable to the ocean waters to the far west of Mount Gambier and to the more rugged terrain farther to the east in the vicinity of Melbourne, Victoria. The remaining objectives concentrate on resolving unsatisfactory aspects of the model such as the evolution of convective lines and the relationship between the surface cold front and the upper-tropospheric cold pool and its associated jet stream.The integrated nature of the Cold Fronts Research Programme has meant that it has stimulated a wide range of research activities that extend beyond the field observations. The associated investigations include climatological, theoretical, and numerical modeling studies.

  18. Laboratory Directed Research and Development FY 2000 Annual Progress Report

    SciTech Connect

    Los Alamos National Laboratory

    2001-05-01

    This is the FY00 Annual Progress report for the Laboratory Directed Research and Development (LDRD) Program at Los Alamos National Laboratory. It gives an overview of the LDRD Program, summarizes progress on each project conducted during FY00, characterizes the projects according to their relevance to major funding sources, and provides an index to principal investigators. Project summaries are grouped by LDRD component: Directed Research and Exploratory Research. Within each component, they are further grouped into the ten technical categories: (1) atomic, molecular, optical, and plasma physics, fluids, and beams, (2) bioscience, (3) chemistry, (4) computer science and software engineering, (5) engineering science, (6) geoscience, space science, and astrophysics, (7) instrumentation and diagnostics, (8) materials science, (9) mathematics, simulation, and modeling, and (10) nuclear and particle physics.

  19. Environmental Research Division technical progress report, January 1984-December 1985

    SciTech Connect

    Not Available

    1986-05-01

    Technical progress in the various research and assessment activities of Argonne National Laboratory's Environmental Research Division is reported for the period 1984 to 1985. Textual, graphic, and tabular information is used to briefly summarize (in separate chapters) the work of the Division's Atmospheric Physics, Environmental Effects Research, Environmental Impacts, Fundamental Molecular Physics and Chemistry, and Waste Management Programs. Information on professional qualifications, awards, and outstanding professional activities of staff members, as well as lists of publications, oral presentations, special events organized, and participants in educational programs, are provided in appendices at the end of each chapter.

  20. Research progress of microbial corrosion of reinforced concrete structure

    NASA Astrophysics Data System (ADS)

    Li, Shengli; Li, Dawang; Jiang, Nan; Wang, Dongwei

    2011-04-01

    Microbial corrosion of reinforce concrete structure is a new branch of learning. This branch deals with civil engineering , environment engineering, biology, chemistry, materials science and so on and is a interdisciplinary area. Research progress of the causes, research methods and contents of microbial corrosion of reinforced concrete structure is described. The research in the field is just beginning and concerted effort is needed to go further into the mechanism of reinforce concrete structure and assess the security and natural life of reinforce concrete structure under the special condition and put forward the protective methods.

  1. [Progress in research of traditional Chinese medicine Citrus aurantium].

    PubMed

    Zhang, Xiao-xiao; Li, Zheng-yong; Ma, Yu-ling; Ma, Shuang-cheng

    2015-01-01

    Citrus aurantium is one of the most common traditional Chinese medicines. In this paper, the chemical components, content determination and pharmacological actions of C. aurantium were summarized for the comprehensive utilization of its resources. Because of the complicated resources of C. aurantium, only one single component as index couldn't reflect the quality and effects and comprehensive evaluation which concluding multiple components should be established in the future quality control. In recent years, the pharmacological effects research of C. aurantium has made tremendous progress, and it is important to explore new drugs from the development and utilization of the active ingredient of C. aurantium. In recent years, the pharmacological effects research of C. aurantium has made tremendous progress, and it is important to explore new drugs from the development and utilization of the active ingredient of C. aurantium. PMID:26080542

  2. [Research progress of alternative production approaches of salidroside].

    PubMed

    Wu, Xiu-Wen; Peng, Yu-Shuai; Wang, Ru-Feng

    2013-11-01

    Salidroside, one of the active components of Rhodiola plants, is a phenolic glycoside with significant biological activities. The investigation and development of alternative production approaches of salidroside is of high academic and application values due to the limited resource of Rhodiola plants, and from which the low yield of salidroside. This review summarized the research progress and perspective of the alternative production approaches of salidroside including both chemosynthetic and biosynthetic methods and pathways. PMID:24494549

  3. [Progress on space oral medicine research under microgravity environment].

    PubMed

    Jing, Chen; Xingqun, Cheng; Xin, Xu; Xuedong, Zhou; Yuqing, Li

    2016-02-01

    As an interdisciplinary of stomatology and space medicine, space oral medicine focuses mainly on oral diseases happened under space environment. With the manned space technology stepping into the new era, space oral medicine has been put under the spotlight. This article will review the historical events on this subject, summarize the newly progress especially on craniomaxillofacial bone, tooth-derived stem cell and oral microbiology researches and still put forward future prospect. PMID:27266206

  4. Research progress of stem cells on glaucomatous optic nerve injury.

    PubMed

    Zhou, Ya-Sha; Xu, Jian; Peng, Jun; Li, Ping; Wen, Xiao-Juan; Liu, Yue; Chen, Ke-Zhu; Liu, Jia-Qi; Wang, Ying; Peng, Qing-Hua

    2016-01-01

    Glaucoma, the second leading cause of blindness, is an irreversible optic neuropathy. The mechanism of optic nerve injury caused by glaucoma is undefined at present. There is no effective treatment method for the injury. Stem cells have the capacity of self-renewal and differentiation. These two features have made them become the research focus on improving the injury at present. This paper reviews the application progress on different types of stem cells therapy for optic nerve injury caused by glaucoma. PMID:27588279

  5. Research progress of stem cells on glaucomatous optic nerve injury

    PubMed Central

    Zhou, Ya-Sha; Xu, Jian; Peng, Jun; Li, Ping; Wen, Xiao-Juan; Liu, Yue; Chen, Ke-Zhu; Liu, Jia-Qi; Wang, Ying; Peng, Qing-Hua

    2016-01-01

    Glaucoma, the second leading cause of blindness, is an irreversible optic neuropathy. The mechanism of optic nerve injury caused by glaucoma is undefined at present. There is no effective treatment method for the injury. Stem cells have the capacity of self-renewal and differentiation. These two features have made them become the research focus on improving the injury at present. This paper reviews the application progress on different types of stem cells therapy for optic nerve injury caused by glaucoma. PMID:27588279

  6. Oil shale research and coordination. Progress report, 1980-1981

    SciTech Connect

    Chappell, W R

    1981-01-01

    Purpose is to evaluate the environmental and health consequences of the release of toxic trace elements by an oil shale industry. Emphasis is on the five elements As, Mo, F, Se, and B. Results of four years' research are summarized and the research results over the past year are reported in this document. Reports by the task force are included as appendices, together with individual papers on various aspects of the subject topic. Separate abstracts were prepared for the eleven individual papers. A progress report on the IWG oil shale risk analysis is included at the end of this document. (DLC)

  7. Marine meteorology research progress of China from 2003 to 2006

    NASA Astrophysics Data System (ADS)

    Wang, Dongxiao; Zhang, Yan; Zeng, Lili; Luo, Lin

    2009-01-01

    The progress in marine meteorology research achieved by scientists in China during the four-year period from 2003 to 2006 is summarized under four categories: marine disaster study, typhoon over the ocean, ocean-atmosphere monitoring technology, and ocean-atmosphere forecasting technology. Compared to the previous four years, many more first-hand datasets have been obtained and more scientific issues have been addressed. In particular, many contributions have been made by young scientists. A brief statement on the research strategy of marine meteorology in China for the coming years is given at the end.

  8. Engineering research progress report, October 1983-March 1984

    SciTech Connect

    Woo, H.H.; Cherniak, J.C.; Hymer, J.D.; Kamelgarn, M.B.

    1984-08-01

    Our intent in this progress report is to provide a summary of the activities pursued by members of the Mechanical Engineering (ME) Department's Engineering Research Program. The Program's mission is to do research for specific applications in mechanical-engineering fields that are of immediate or potential interest to the Laboratory. The FY84 Program comprises nine projects in four thrust areas in the ME Department. The thrust areas are: Surface Measurements and Characterization; Fabrication Technology; Materials Characterization and Behavior; and Computer-Aided Engineering. In the past, our research was supported almost exclusively by weapons programs; recently, however, we significantly increased our involvement in other Laboratory programs as well. In response to this change, we have established new procedures and guidelines for the submission, review, and selection of research proposals.

  9. Overview of research in progress at the Center of Excellence

    NASA Technical Reports Server (NTRS)

    Wandell, Brian A.

    1993-01-01

    The Center of Excellence (COE) was created nine years ago to facilitate active collaboration between the scientists at Ames Research Center and the Stanford Psychology Department. Significant interchange of ideas and personnel continues between Stanford and participating groups at NASA-Ames; the COE serves its function well. This progress report is organized into sections divided by project. Each section contains a list of investigators, a background statement, progress report, and a proposal for work during the coming year. The projects are: Algorithms for development and calibration of visual systems, Visually optimized image compression, Evaluation of advanced piloting displays, Spectral representations of color, Perception of motion in man and machine, Automation and decision making, and Motion information used for navigation and control.

  10. [Research progress on molecular genetics of forest musk deer].

    PubMed

    Jie, Hang; Zheng, Cheng-li; Wang, Jian-ming; Feng, Xiao-lan; Zeng, De-jun; Zhao, Gui-jun

    2015-11-01

    Forest musk deer is one of the large-scale farming musk deer animals with the largest population at the same time. The male musk deer can secrete valuable medicines, which has high medicinal and economic value. Due to the loss of habitat and indiscriminate hunting, the numbers of wild population specie and the distribution have been drastically reduced. Therefore, in-depth understanding of the molecular genetics progress of forest musk deer will pave a way for musk deer protection and breeding. In this review, the progress associated with the molecular marker, genetic classification, artificial breeding, musk secretion and disease in past decades were reviewed, in order to provide a theoretical basis for subsequent molecular genetic researches in forest musk deer. PMID:27097400

  11. Evacuated Window Glazing Research and Development: A Progress Report

    SciTech Connect

    Benson, D. K.; Tracy, C. E.; Jorgensen, G. J.

    1984-12-01

    This document summarizes progress during a nine-month period of an ongoing, exploratory research talk. The objective of the research is to evaluate the technical feasibility of a highly insulating, evacuated glazing for windows and other building apertures. Research includes engineering design and analysis of the glazing structure, materials development for its components, and the development of fabrication processes that could be used in the practical, mass production of such a glazing system. The targeted design performance goals are 70 percent solar weighted transmittance with less than 0.5 W/m2 K conductance (insulating R value greater than 12 F ft2 h/Btu) with an acceptable view quality.

  12. Animal research ethics in Africa: is Tanzania making progress?

    PubMed

    Seth, Misago; Saguti, Fredy

    2013-12-01

    The significance of animals in research cannot be over-emphasized. The use of animals for research and training in research centres, hospitals and schools is progressively increasing. Advances in biotechnology to improve animal productivity require animal research. Drugs being developed and new interventions or therapies being invented for cure and palliation of all sorts of animal diseases and conditions need to be tested in animals for their safety and efficacy at some stages of their development. Drugs and interventions for human use pass through a similar development process and must be tested pre-clinically in laboratory animals before clinical trials in humans can be conducted. Therefore, animals are important players in research processes which directly and indirectly benefit animals and humans. However, questions remain as to whether these uses of animals consider the best interests of animals themselves. Various research and training institutions in Tanzania have established some guidelines on animal use, including establishing animal ethics committees. However, most institutions have not established oversight committees. In institutions where there may be guidelines and policies, there are no responsible committees or units to directly oversee if and how these guidelines and policies are enforced; thus, implementation becomes difficult or impossible. This paper endeavours to raise some issues associated with the responsible use of animals in research and training in Tanzania and highlights suggestions for improvement of deficiencies that exist in order to bridge the gap between what ought to be practised and what is practised. PMID:23006770

  13. Research on human genetics in Iceland. Progress report

    SciTech Connect

    1980-10-31

    Records of the Icelandic Population are being used to investigate the possible inheritance of disabilities and diseases as well as other characters and the effect of environment on man. The progress report of research covers the period 1977 to 1980. The investigation was begun in 1965 by the Genetical Committee of the University of Iceland and the materials used are demographic records from the year 1840 to present and various medical information. The records are being computerized and linked together to make them effective for use in hereditary studies.

  14. Progress report on research on human genetics in Iceland

    SciTech Connect

    1980-10-31

    Records of the Icelandic population are being used to investigate the possible inheritance of disabilities and diseases as well as other characteristics and the effect of environment on man. The progress report of research covers the period from 1977 to 1980. The investigation was begun in 1965 by the Genetical Committee of the University of Iceland and the materials used are demographic records from the year 1840 to present and various medical information. The records are being computerized and linked together to make them effective for use in hereditary studies.

  15. FY2012 Progress Report for Energy Storage Research & Development

    SciTech Connect

    none,

    2013-01-01

    FY 2012 annual report of the energy storage research and development effort within the VT Office. An important step for the electrification of the nation’s light duty transportation sector is the development of more cost-effective, long lasting, and abuse-tolerant PEV batteries. In fiscal year 2012, battery R&D work continued to focus on the development of high-energy batteries for PEVs and very high power devices for hybrid vehicles. This document provides a summary and progress update of the VTP battery R&D projects that were supported in 2012.

  16. [Research Progress in Measurement of Human Accommodative Amplitude].

    PubMed

    Long, Erping; Lin, Haotian

    2015-09-01

    Accommodation is an important function of the human eye, which can change the parameters of ocular refractive system and also has a strong correlation with the development of myopia and presbyopia. Several subjective measurements have been applied in accommodation assessment such as push-up test, push-down test and minus-lens procedures. It can be measured objectively by measuring the change in refraction of the eye with dynamic retinoscopy or autorefractor. This article reviews the application of measurement of accommodative amplitude and research progress in accommodation, providing clinical information for further studies. PMID:26930838

  17. Recent Progress in Redox Flow Battery Research and Development

    SciTech Connect

    Wang, Wei; Luo, Qingtao; Li, Bin; Wei, Xiaoliang; Li, Liyu; Yang, Zhenguo

    2013-02-20

    With the increase need to seamlessly integrate the renewable energy with the current grid which itself is evolving into a more intelligent, efficient, and capable electrical power system, it is envisioned that the energy storage system will play a more prominent role in bridging the gap between the current technology and a clean sustainable future in grid reliability and utilization. Redox flow battery technology is leading the way in this perspective in providing a well balanced approach for current challenges. Recent progress in the research and development of redox flow battery technology is reviewed here with a focus on new chemistries and systems.

  18. Progress in research into the genes associated with venous thromboembolism

    PubMed Central

    Zhao, Lian-xing; Liu, Bo; Li, Chun-sheng

    2015-01-01

    BACKGROUND: Venous thromboembolism (VTE), including both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common, lethal disorder that affects hospitalized and non-hospitalized patients. This study aimed to review the progress in the research into VTE. DATA SOURCES: We reviewed the studies about VTE and verified different genetic polymoriphisms of VTE. RESULTS: The pathogenesis of VTE involves hereditary and acquired factors. Many studies indicated that the disorder of coagulation and fibirnolytic system is of utmost importance to this disease. Genetic polymoriphism-related VTE demonstrated significant differences among geographies and ethnicities. CONCLUSION: VTE has many risk factors, but genetic factors play an important role. PMID:26056539

  19. Estuarine Physical Processes Research: Some Recent Studies and Progress

    NASA Astrophysics Data System (ADS)

    Uncles, R. J.

    2002-12-01

    The literature on estuarine physical studies is vast, diverse and contains many valuable case studies in addition to pure, process-based research. This essay is an attempt to summarize both some of the more recent studies that have been undertaken during the last several years, as well as some of the trends in research direction and progress that they represent. The topics covered include field and theoretical studies on hydrodynamics, turbulence, salt and fine sediment transport and morphology. The development and ease-of-application of numerical and analytical models and technical software has been essential for much of the progress, allowing the interpretation of large amounts of data and assisting with the understanding of complex processes. The development of instrumentation has similarly been essential for much of the progress with field studies. From a process viewpoint, much more attention is now being given to interpreting intratidal behaviour, including the effects of tidal straining and suspended fine sediment on water column stratification, stability and turbulence generation and dissipation. Remote sensing from satellites and aircraft, together with fast sampling towed instruments and high frequency radar now provide unique, frequently high resolution views of spatial variability, including currents, frontal and plume phenomena, and tidal and wave-generated turbidity. Observations of fine sediment characteristics (floc size, aggregation mechanisms, organic coatings and settling velocity) are providing better parameterizations for sediment transport models. These models have enhanced our understanding both of the estuarine turbidity maximum and its relationship to fronts and intratidal hydrodynamic and sedimentological variability, as well as that of simple morphological features such as intertidal mudflats. Although few, interdisciplinary studies to examine the relationships between biology and estuarine morphology show that bivalve activity and the

  20. Laboratory directed research and development: FY 1997 progress report

    SciTech Connect

    Vigil, J.; Prono, J.

    1998-05-01

    This is the FY 1997 Progress Report for the Laboratory Directed Research and Development (LDRD) program at Los Alamos National Laboratory. It gives an overview of the LDRD program, summarizes work done on individual research projects, relates the projects to major Laboratory program sponsors, and provides an index to the principal investigators. Project summaries are grouped by their LDRD component: Competency Development, Program Development, and Individual Projects. Within each component, they are further grouped into nine technical categories: (1) materials science, (2) chemistry, (3) mathematics and computational science, (4) atomic and molecular physics and plasmas, fluids, and particle beams, (5) engineering science, (6) instrumentation and diagnostics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) bioscience.

  1. Research And Development Contributions to Aviation Progress (RADCAP): Executive summary

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Positive contributions of military aeronautical research and development programs to civil aviation are reviewed and some possible future contributions of those military programs are assessed. A summary is presented of detailed results concerned with: (1) review of the progress that has been made in aviation since 1925 and the significant technological advances that have been made; (2) an examination of current and planned military aeronautical research and technology programs and an assessment of their relevancy to the aeronautical R and D needs of civil aviation; (3) the relationship of the development base generated by military programs to the needs of civil airliner design, development, and production; (4) information on aeronautical R and D funding; and (5) the findings and observations of the RADCAP study.

  2. Laboratory Directed Research and Development FY 1998 Progress Report

    SciTech Connect

    John Vigil; Kyle Wheeler

    1999-04-01

    This is the FY 1998 Progress Report for the Laboratory Directed Research and Development (LDRD) Program at Los Alamos National Laboratory. It gives an overview of the LDRD Program, summarizes work done on individual research projects, relates the projects to major Laboratory program sponsors, and provides an index to the principle investigators. Project summaries are grouped by their LDRD component: Competency Development, Program Development, and Individual Projects. Within each component, they are further grouped into nine technical categories: (1) materials science, (2) chemistry, (3) mathematics and computational science, (4) atomic, molecular, optical, and plasma physics, fluids, and particle beams, (5) engineering science, (6) instrumentation and diagnostics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) bioscience.

  3. Research progress of cardioprotective agents for prevention of anthracycline cardiotoxicity

    PubMed Central

    Zhang, Jing; Cui, Xiaohai; Yan, Yan; Li, Min; Yang, Ya; Wang, Jiansheng; Zhang, Jia

    2016-01-01

    Anthracyclines, including doxorubicin, epirubicin, daunorubicin and aclarubicin, are widely used as chemotherapeutic agents in the treatment of hematologic and solid tumor, including acute leukemia, lymphoma, breast cancer, gastric cancer, soft tissue sarcomas and ovarian cancer. In the cancer treatment, anthracyclines also can be combined with other chemotherapies and molecular-targeted drugs. The combination of anthracyclines with other therapies is usually the first-line treatment. Anthracyclines are effective and potent agents with a broad antitumor spectrum, but may cause adverse reactions, including hair loss, myelotoxicity, as well as cardiotoxicity. We used hematopoietic stimulating factors to control the myelotoxicity, such as G-CSF, EPO and TPO. However, the cardiotoxicity is the most serious side effect of anthracyclines. Clinical research and practical observations indicated that the cardiotoxicity of anthracyclines is commonly progressive and irreversible. Especially to those patients who have the first time use of anthracyclines, the damage is common. Therefore, early detection and prevention of anthracyclines induced cardiotoxicity are particularly important and has already aroused more attention in clinic. By literature review, we reviewed the research progress of cardioprotective agents for prevention of anthracycline cardiotoxicity. PMID:27508008

  4. Research Progress in Pseudoxanthoma Elasticum and Related Ectopic Mineralization Disorders

    PubMed Central

    Li, Qiaoli; Arányi, Tamás; Váradi, András; Terry, Sharon F.; Uitto, Jouni

    2015-01-01

    Heritable ectopic mineralization disorders represent a phenotypically diverse group of conditions characterized by deposition of calcium phosphate complexes in soft connective tissues. The prototype of such conditions is pseudoxanthoma elasticum (PXE), and related conditions with overlapping clinical features include generalized arterial calcification of infancy (GACI) and arterial calcification due to CD73 deficiency (ACDC). Molecular genetic investigations have revealed mutations in the genes physiologically involved in generation of inorganic pyrophosphate (PPi) and phosphate (Pi), and the findings suggest a unifying pathomechanism relating to reduced PPi/Pi ratio. This hypothesis is based on the notion that PPi serves as a powerful inhibitor of mineralization while Pi is a pro-mineralization factor, and an appropriate PPi/Pi ratio is critical for prevention of ectopic mineralization under homeostatic conditions. PXE International, the premiere patient support organization, advocating on behalf of patients and families with PXE, sponsors regular research meetings evaluating the progress in this and related ectopic mineralization disorders. The latest meetings were held in September 2014 in Bethesda, MD and in September 2015 in Budapest, Hungary. This report summarizes the latest progress in research on PXE and related ectopic mineralization disorders, based on presentations and discussions in these meetings, with pharmacologic implications for currently intractable disorders. PMID:26902123

  5. [Research progress and direction of atmospheric brown carbon].

    PubMed

    Yan, Cai-Qing; Zheng, Mei; Zhang, Yuan-Hang

    2014-11-01

    Organic aerosol is one of the most important components of atmospheric aerosols. In recent years, organic aerosol has been found and proved to be light absorbing in UV-Visible region. Light absorbing organic carbon (also named as brown carbon) has been one of the forefronts in the field of atmospheric research. Its light absorption contributions to radiative forcing, regional air quality, and global climate change have drawn much attention. Regional air pollution is complex in China. Frequent visibility decline and severe regional haze episodes occurred since January 2013. Previous studies showed high amount of estimated columnar light-absorbing organic carbon in China, and according to current research findings, major sources of fine particulate matter in China (e. g. biomass burning and fossil fuel combustion) were also recognized as the main sources for brown carbon. Considering the high abundance of brown carbon in atmosphere, there is a great need to reconsider and reevaluate contributions of organic aerosol to light absorption, especially its role in haze formation and radiative forcing. However, up to now, basic researches on light absorbing organic carbon are still limited in China. This study aimed to elucidate the need for basic research on brown carbon, summarize previous studies and research progress from different aspects such as sources, composition, measurement, mass concentration distribution, optical property, radiative forcing of brown carbon, point out the existing problems and deficiencies, and put forward suggestions for future study. PMID:25639123

  6. Research Progress in the DOE/SERI Amorphous Silicon Research Project

    SciTech Connect

    Sabisky, E.; Wallace, W.; Stafford, B.; Sadlon, K.; Luft, W.

    1985-04-01

    The Amorphous Silicon Research Project (ASRP), established at the Solar Energy Research Institute (SERI) in 1983, is responsible for all U.S. DOE government-supported research activities in the field of amorphous silicon photovoltaics. The objectives and research directions of the project have been established by a Five-Year Research Plan developed at SERI in cooperation with the Department of Energy in 1984. In order to accomplish project goals, research is performed by a combination of i) multi-year programs consisting of multi-disciplinary research teams based on strong government/industry partnerships and ii) basic research performed in university, government, and industrial laboratories. A summary of recent research progress in the ASRP program is presented.

  7. [Research progress on techniques for artificial propagation of corals].

    PubMed

    Wang, Shu-hong; Hong, Wen-ting; Chen, Ji-xin; Chen, Yun; Wang, Yi-lei; Zhang, Zi-ping; Weng, Zhao-hong; Xie, Yang-jie

    2015-09-01

    The natural coral reef resources degrade rapidly because of climate change, environmental pollution and exploitation of aquarium species. Artificial propagation is an effective way to facilitate the reduction of wild harvesting, reef restoration, preservation of biodiversity. This paper reviewed the technique and research progresses focused on coral artificial propagation. We compared the advantages and disadvantages of sexual reproduction and asexual reproduction as well as in situ and ex situ propagation. Moreover, we summarized the important roles of irradiation, flow rate, nutrients, feed and other factors in coral propagation within recirculating aquaculture system (RAS). Irradiation is the key to successful ex situ coral culture and different species show different needs of radiation intensity and light spectrum. Therefore, artificial lighting in RAS, as well as. power and maintenance costs, are very important for ex situ coral aquaculture. In addition, corals are very sensitive to NH4+, NO3-, NO2- as well as phosphate in RAS, and many physical, chemical and biological methods are acquired to maintain low nutrients condition. Although RAS has progressed a lot in terms of irradiation, flow rate and nutrient control, future studies also should focus on sexual reproduction, genetic modification and disease control. PMID:26785577

  8. [Research Progress on Cytometric Bead Assay for Platelet Antibody Detection].

    PubMed

    Ling, Yun; Kong, Xin; Chen, Bao-An

    2015-08-01

    Anti-platelet specific antibody is one of the most important reasons leading to thrombocytopenia and megakaryocyte dysmaturity. The detection of platelet autoantibodies is an important step in the diagnosis of ITP because of the absence of specific clinic feature. The monoclonal antibody-specific immobilization of platelet antigens (MAIPA) has become a "gold standard" for determination of PLT specific antibody, which has high specificity and low sensitivity. However, this assay is time-consuming and tedious work. Routine use of this assay in hospital is difficult. Recently, some researches reporded the cytometric bead assay that has higher sensitivity than MAIPA, and so probably solves the problem of time-consuming partly, that also can use different beads for simultaneous detection. This review focuses on recent progress of the cytometric bead assay. PMID:26314475

  9. Progress in InP solar cell research

    NASA Technical Reports Server (NTRS)

    Weinberg, Irving; Brinker, David J.

    1988-01-01

    Progress, in the past year, in InP solar cell research is reviewed. Small area cells with AMO, total area efficiencies of 18.8 percent were produced by OMCVD and Ion Implantation. Larger area cells (2 and 4 sq cm) were processed on a production basis. One thousand of the 2 sq cm cells will be used to supply power to a small piggyback lunar orbiter scheduled for launch in February 1990. Laboratory tests of ITO/InP cells, under 10 MeV proton irradiation, indicate radiation resistance comparable to InP n/p homojunction cells. Computer modeling studies indicate that, for identical geometries and dopant concentrations, InP solar cells are significantly more radiation resistant than GaAs under 1 MeV electron irradiation. Additional computer modeling calculations were used to produce rectangular and circular InP concentrator cell designs for both the low concentration SLATS and higher concentration Cassegrainian Concentrators.

  10. [Research progress of methods for brain vigilance improvement].

    PubMed

    Zhu, Xianfeng; Liu, Yating; Zhang, Yi; Zhou, Peng; Wang, Mingshi

    2013-06-01

    Vigilance is defined as the ability to maintain attention or alertness over prolonged periods of time. Since Mid-20th century, following the increasing man-machine communication, high level of vigilance has been demanded in many areas including driving safety, medical care and therapy, aerospace and military affairs, etc. Therefore, finding quick methods to improve the level of vigilance has become a key issue in medical study. Based on physical regulation, chemical regulation and physiological regulation, the research progress has been summarized in this paper. We, furthermore, also try to predict the future trend in this academic area and develop some tentative ideas about seeking more effective and convenient ways to improve the level of brain vigilance. PMID:23865336

  11. Noncoding RNAs in gastric cancer: Research progress and prospects

    PubMed Central

    Zhang, Meng; Du, Xiang

    2016-01-01

    Noncoding RNAs (ncRNAs) have attracted much attention in cancer research field. They are involved in cellular development, proliferation, differentiation and apoptosis. The dysregulation of ncRNAs has been reported in tumor initiation, progression, invasion and metastasis in various cancers, including gastric cancer (GC). In the past few years, an accumulating body of evidence has deepened our understanding of ncRNAs, and several emerging ncRNAs have been identified, such as PIWI-interacting RNAs (piRNAs) and circular RNAs (circRNAs). The competing endogenous RNA (ceRNA) networks include mRNAs, microRNAs, long ncRNAs (lncRNAs) and circRNAs, which play critical roles in the tumorigenesis of GC. This review summarizes the recent hotspots of ncRNAs involved in GC pathobiology and their potential applications in GC. Finally, we briefly discuss the advances in the ceRNA network in GC. PMID:27547004

  12. [Research progress on anti-tumor effect of Huaier].

    PubMed

    Yang, Ai-lin; Hu, Zhong-dong; Tu, Peng-fei

    2015-12-01

    Huaier (Trametes robiniophila) has been widely used as an adjuvant drug for cancer treatment in China. The anti-cancer effect of Huaier extract has been confirmed in liver cancer, lung cancer, breast cancer, ovarian cancer, gastric cancer, and so on. The main mechanisms by which Huaier exerts an anti-neoplastic effect include inhibition of the growth and proliferation of cancer cells, induction of apoptosis of cancer cells, suppression of angiogenesis, inhibition of the invasion and migration of cancer cells, regulation of oncogenes and tumor suppressor genes expression, improving immunity, and reversal of drug resistance in cancer cells. In order to provide references for further study and clinical application on anti-tumor effect of Huaier, the latest research progress on anti-tumor effect of Huaier in recent years is summarized in this paper. PMID:27245026

  13. [Characteristics of molecular genetics and research progress on mitochondrial diseases].

    PubMed

    Zhang, Meng; Si, Yanmei; Zhao, Juan

    2016-10-01

    Mitochondrial diseases is a group of metabolic disorders caused by abnormal structure and dysfunction of mitochondrial DNA (mtDNA). Abnormalities of mtDNA include point mutations, deletions, and rearrangements and depletion of mtDNA. These may affect the ability of mitochondria to generate energy in cells of various tissues and organs. As many factors are involved in the regulation of mtDNA mutations, most mitochondrial diseases may manifest great genetic heterogeneity and a wide spectrum of clinical manifestations. On the other hand, for the low prevalence of single disease, these disorders may be easily missed or with delayed diagnosis. This review focuses on the pathological mutations and benign variations of mtDNA, and research progress on such disorders. PMID:27577231

  14. [Research Progress on Artemisinin Resistance in Plasmodium falciparum].

    PubMed

    Zhang, Yi-long; Pan, Wei-qing

    2015-12-01

    Artemisinin (ART) is a novel and effective antimalarial drug discovered in China. As recommended by the World Health Organization, the ART-based combination therapies (ACTs) have become the first-line drugs for the treatment of falciparum malaria. ART and its derivatives have contributed greatly to the effective control of malaria globally, leading to yearly decrease of malaria morbidity and mortality. However, there have recently been several reports on the resistance of Plasmodium falciparum to ART in Southeast Asia. This is deemed a serious threat to the global malaria control programs. In this paper, we reviewed recent research progress on ART resistance to P. falciparum, including new tools for resistance measurement, resistance-associated molecular markers, and the origin and spread of the ART-resistant parasite strains. PMID:27089770

  15. Recent research progress with phospholipase C from Bacillus cereus.

    PubMed

    Lyu, Yan; Ye, Lidan; Xu, Jun; Yang, Xiaohong; Chen, Weiwei; Yu, Hongwei

    2016-01-01

    Phospholipase C (PLC) catalyzes the hydrolysis of phospholipids to produce phosphate monoesters and diacylglycerol. It has many applications in the enzymatic degumming of plant oils. PLC Bc , a bacterial PLC from Bacillus cereus, is an optimal choice for this activity in terms of its wide substrate spectrum, high activity, and approved safety. Unfortunately, its large-scale production and reliable high-throughput screening of PLC Bc remain challenging. Herein, we summarize the research progress regarding PLC Bc with emphasis on the screening methods, expression systems, catalytic mechanisms and inhibitor of PLC Bc . This review hopefully will inspire new achievements in related areas, to promote the sustainable development of PLC Bc and its application. PMID:26437973

  16. [Research progress in post-fire debris flow].

    PubMed

    Di, Xue-ying; Tao, Yu-zhu

    2013-08-01

    The occurrence of the secondary disasters of forest fire has significant impacts on the environment quality and human health and safety. Post-fire debris flow is one of the most hazardous secondary disasters of forest fire. To understand the occurrence conditions of post-fire debris flow and to master its occurrence situation are the critical elements in post-fire hazard assessment. From the viewpoints of vegetation, precipitation threshold and debris flow material sources, this paper elaborated the impacts of forest fire on the debris flow, analyzed the geologic and geomorphic conditions, precipitation and slope condition that caused the post-fire debris flow as well as the primary mechanisms of debris-flow initiation caused by shallow landslide or surface runoff, and reviewed the research progress in the prediction and forecast of post-fire debris flow and the related control measures. In the future research, four aspects to be focused on were proposed, i. e., the quantification of the relationships between the fire behaviors and environmental factors and the post-fire debris flow, the quantitative research on the post-fire debris flow initiation and movement processes, the mechanistic model of post-fire debris flow, and the rapid and efficient control countermeasures of post-fire debris flow. PMID:24380363

  17. [Research progress in health impact of traffic noise].

    PubMed

    Huang, Jing; Guo, Bin; Guo, Xin-biao

    2015-06-18

    Traffic noise pollution problem is increasingly emerging with the rapid development of urban traffic. Researchers have paid close attention to the health effects of traffic noise. This review has summarized the recent research progress in the health effects of traffic noise both at home and abroad. Traffic noise can have various adverse health effects, and most of them are extra-auditory effects. The main aspects include that traffic noise can affect the cardiovascular system, which is verified by the evidence that exposure to traffic noise significantly increases the risk for cardiovascular diseases, such as high blood pressure, myocardial infarction, coronary heart disease, and so on. In addition, traffic noise can induce adverse effects on nervous system, leading to the increasing levels of anxiety, noise annoyance, and occurrence of insomnia. Furthermore, traffic noise is significantly associated with adverse pregnant outcomes, and can affect the endocrine system and digestive system. As traffic noise and traffic related air pollutants co-exist in the traffic environment, whether there are joint effects between these two factors have become areas of research focus nowadays. Although there is sufficient evidence that traffic noise has adverse health effects, inadequacies still existe. Analysis of the shortages of current studies and the prospects of the future studies are pointed out in this review. PMID:26080892

  18. [Research progress on water footprint in agricultural products].

    PubMed

    Lu, Yang; Liu, Xiu-wei; Zhang, Xi-ying

    2015-10-01

    Water is one of the important resources in human activities. Scientifically and rationally evaluating the effects of human activities on water resources is important for sustainable water resource management. The innovative concepts of water footprint (WF) distinguished the human water consumption into green water, blue water and grey water which extended the evaluation methods in sustainable utilization of water resources. Concepts of WF based on virtual water (VW) and based on life cycle assessment (LCA) both combined water quality and water quantity are now the focuses in agricultural water management researches. Theory of WF based on VW includes the calculation of green, blue and grey WF as well as the evaluation of the sustainability of water environment. Theory of WF based on LCA reflects the overall impact of consumptive and degradative water use on the environment. The purpose of this article was to elaborate the research progresses in theoretical calculation methods and environmental sustainability assessment of the two water footprint theories and then to analyze the differentiation of these two methodologies in describing the consumptive water use in agriculture and its effects on environment. Finally, some future research aspects on water footprint were provided. PMID:26995933

  19. SCN8A encephalopathy: Research progress and prospects.

    PubMed

    Meisler, Miriam H; Helman, Guy; Hammer, Michael F; Fureman, Brandy E; Gaillard, William D; Goldin, Alan L; Hirose, Shinichi; Ishii, Atsushi; Kroner, Barbara L; Lossin, Christoph; Mefford, Heather C; Parent, Jack M; Patel, Manoj; Schreiber, John; Stewart, Randall; Whittemore, Vicky; Wilcox, Karen; Wagnon, Jacy L; Pearl, Phillip L; Vanderver, Adeline; Scheffer, Ingrid E

    2016-07-01

    On April 21, 2015, the first SCN8A Encephalopathy Research Group convened in Washington, DC, to assess current research into clinical and pathogenic features of the disorder and prepare an agenda for future research collaborations. The group comprised clinical and basic scientists and representatives of patient advocacy groups. SCN8A encephalopathy is a rare disorder caused by de novo missense mutations of the sodium channel gene SCN8A, which encodes the neuronal sodium channel Nav 1.6. Since the initial description in 2012, approximately 140 affected individuals have been reported in publications or by SCN8A family groups. As a result, an understanding of the severe impact of SCN8A mutations is beginning to emerge. Defining a genetic epilepsy syndrome goes beyond identification of molecular etiology. Topics discussed at this meeting included (1) comparison between mutations of SCN8A and the SCN1A mutations in Dravet syndrome, (2) biophysical properties of the Nav 1.6 channel, (3) electrophysiologic effects of patient mutations on channel properties, (4) cell and animal models of SCN8A encephalopathy, (5) drug screening strategies, (6) the phenotypic spectrum of SCN8A encephalopathy, and (7) efforts to develop a bioregistry. A panel discussion of gaps in bioregistry, biobanking, and clinical outcomes data was followed by a planning session for improved integration of clinical and basic science research. Although SCN8A encephalopathy was identified only recently, there has been rapid progress in functional analysis and phenotypic classification. The focus is now shifting from identification of the underlying molecular cause to the development of strategies for drug screening and prioritized patient care. PMID:27270488

  20. Progress in Research on Diurnal and Semidiurnal Earth Rotation Change

    NASA Astrophysics Data System (ADS)

    Xu, X.; Dong, D.; Zhou, Y.

    2014-12-01

    We mainly focus on the progress of research on high frequency changes in the earth rotation. Firstly, we review the development course and main motivating factors of the diurnal and semidiurnal earth rotation change. In recent decades, earth orientation has been monitored with increasing accuracy by advanced space-geodetic techniques, including lunar and satellite laser ranging, very long baseline interferometry and the global positioning system. We are able to obtain the Earth Rotation Parameters (ERP, polar motion and rotation rate changes) by even 1 to 2 hours observation data, form which obvious diurnal and semidiurnal signals can be detected, and compare them with the predicted results by the ocean model. Both the amplitude and phase are in good agreement in the main diurnal and semidiurnal wave frequency, especially for the UT1, whose compliance is 90%, and 60% for polar motion, there are 30% motivating factor of the diurnal and semidiurnal polar motion have not been identified. Then we comprehensively review the different types of global ocean tidal correction models since the last eighties century, as well as the application research on diurnal and semidiurnal polar motion and UT1, the current ocean tidal correction models have 10% to 20% uncertainty, and need for further refinement.

  1. Progress in Research on Diurnal and Semidiurnal Earth Rotation Change

    NASA Astrophysics Data System (ADS)

    Xu, Xueqing

    2015-08-01

    We mainly focus on the progress of research on high frequency changes in the earth rotation. Firstly, we review the development course and main motivating factors of the diurnal and semidiurnal earth rotation change. In recent decades, earth orientation has been monitored with increasing accuracy by advanced space-geodetic techniques, including lunar and satellite laser ranging, very long baseline interferometry and the global positioning system. We are able to obtain the Earth Rotation Parameters (ERP, polar motion and rotation rate changes) by even 1 to 2 hours observation data, form which obvious diurnal and semidiurnal signals can be detected, and compare them with the predicted results by the ocean model. Both the amplitude and phase are in good agreement in the main diurnal and semidiurnal wave frequency, especially for the UT1, whose compliance is 90%, and 60% for polar motion, there are 30% motivating factor of the diurnal and semidiurnal polar motion have not been identified. Then we comprehensively review the different types of global ocean tidal correction models since the last eighties century, as well as the application research on diurnal and semidiurnal polar motion and UT1, the current ocean tidal correction models have 10% to 20% uncertainty, and need for further refinement.

  2. Compact Toroidal Hybrid Research Program: Recent Progress and Future Plans

    NASA Astrophysics Data System (ADS)

    Maurer, D. A.; Cianciosa, M.; Hanson, J. D.; Hartwell, G. J.; Hebert, J. D.; Herfindal, J. L.; Knowlton, S. F.; Archmiller, M. C.; Traverso, P.; Pandya, M.; Ma, X.

    2012-10-01

    Understanding the control and avoidance of major disruptions in current carrying toroidal plasmas is important in mitigating the effects of rapid loss of confinement in future devices. The Compact Toroidal Hybrid (CTH) experiment is investigating the passive avoidance of disruptions with the addition of a small amount of vacuum transform provided by external coils. In ohmically-driven stellarator plasmas no disruptions of any kind are observed if the vacuum transform exceeds ˜ 0.11. Recent progress on the suppression of low-qa (high a), density limit, and vertically unstable plasma disruptions is overviewed. Interpretation of these results makes use of 3D equilibrium reconstructions using the V3FIT code [1]. Several new diagnostic tools have recently been developed and implemented on CTH. These new research tools include multi-chord interferometry, bolometry, Hα emission detection, a two-color soft x-ray camera, and upgraded magnetic sensor arrays. In addition to these diagnostic improvements, a new 200 kW gyrotron system will provide additional heating power for stellarator target plasmas. Future research directions and plans will also be discussed. [4pt] [1] J. D. Hanson, S. P. Hirshman, S. F. Knowlton, L. L. Lao, E. A. Lazarus, J. M. Shields, Nucl. Fusion, 49 (2009) 075031

  3. History of Physics Education Research as a Model for Geoscience Education Research Community Progress

    NASA Astrophysics Data System (ADS)

    Slater, T. F.

    2011-12-01

    Discipline-based Education Research (DBER) is a research field richly combining a deep understanding of how to teach a particular discipline with an evolving understanding how people learn that discipline. At its center, DBER has an overarching goal of improving the teaching and learning of a discipline by focusing on understanding the underlying mental mechanisms learners use as they develop expertise. Geoscience Education Research, or GER, is a young but rapidly advancing field which is poised to make important contributions to the teaching and learning of earth and space science. Nascent geoscience education researchers could accelerate their community's progress by learning some of the lessons from the more mature field of Physics Education Research, PER. For the past three decades, the PER community has been on the cutting edge of DBER. PER started purely as an effort among traditionally trained physicists to overcome students' tenaciously held misconceptions about force, motion, and electricity. Over the years, PER has wrestled with the extent to which they included the faculty from the College of Education, the value placed on interpretive and qualitative research methods, the most appropriate involvement of professional societies, the nature of its PhD programs in the College of Science, and how to best disseminate the results of PER to the wider physics teaching community. Decades later, as a more fully mature field, PER still struggles with some of these aspects, but has learned important lessons in how its community progresses and evolves to be successful, valuable, and pertinent.

  4. Research progress of terahertz wave technology in food inspection

    NASA Astrophysics Data System (ADS)

    Yan, Zhanke; Ying, Yibin; Zhang, Hongjian; Yu, Haiyan

    2006-10-01

    Food safety and quality concern have become more and more significant in recent years. There is therefore an increasing focus on new technologies that can be applied to food quality evaluation or safety inspection, either to simplify or speed up the checking process, or to provide additional functionality. For example, the technique of near infrared (NIR) spectroscopy has been used for the authentication of agricultural products and food samples. Terahertz (THz) radiation, or THz wave, is electromagnetic wave lies between mid-infrared and microwave radiation. During the past decade, THz waves have been used to characterize the electronic, vibrational and compositional properties of solid, liquid and gas phase materials. The main two applications in which THz fields involved are THz spectroscopy and THz imaging. Terahertz wave technology, as a new area of research, has shown its wide prospects in imaging, diagnosis, detection, and monitoring, etc. Recently, THz technology has gained a lot of attention from biological spectral analysis to bio-medical imaging due to its unique features compared with microwave and optical waves. In this paper, a brief review is given to summarize the progress of THz techqiues in the field of food inspection. The properties of THz wave, its uniqueness in sensing and imaging applications, and the prospect of this novel technology in food industry were discussed.

  5. Recent progress in artificial organ research at Tohoku University.

    PubMed

    Yambe, Tomoyuki; Yoshizawa, Makoto; Tanaka, Akira; Abe, Ken-ichi; Kawano, Satoyuki; Matsuki, Hidetoshi; Maruyama, Shigenao; Amae, Shintato; Wada, Naoshi; Kamiyama, Takamichi; Takagi, Toshiyuki; Luo, Run; Hayashi, Junko; Kovalev, Yuri A; X D Sha, Dan; Nanka, Shunsuke; Saijo, Yoshifumi; Mibiki, Yoshiyuki; Shibata, Mune-ichi; Nitta, Shin-ichi

    2003-01-01

    Tohoku University has developed various artificial organs over the last 30 years. Pneumatic driven ventricular assist devices with a silicone ball valve have been designed by the flow visualization method, and clinical trials have been performed in Tohoku University Hospital. On the basis of these developments, a pneumatic driven total artificial heart has been developed and an animal experimental evaluation was conducted. The development of artificial organs in Tohoku University has now progressed to the totally implantable type using the transcutaneous energy transmission system with amorphous fibers for magnetic shielding. Examples of implantable systems include a vibrating flow pump for ventricular assist device, an artificial myocardium by the use of shape memory alloy with Peltier elements, and an artificial sphincter for patients with a stoma. An automatic control system for artificial organs had been developed for the ventricular assist devices including a rotary blood pump to avoid suction and to maintain left and right heart balance. Based upon the technology of automatic control algorithm, a new diagnostic tool for evaluating autonomic nerve function has been developed as a branch of artificial organ research and this new machine has been tested in Tohoku University Hospital. Tohoku University is following a variety of approaches aimed at innovation in artificial organs and medical engineering fields. PMID:12534706

  6. Ceramic breeder research and development: progress and focus

    NASA Astrophysics Data System (ADS)

    van der Laan, J. G.; Kawamura, H.; Roux, N.; Yamaki, D.

    2000-12-01

    The world-wide efforts on ceramic breeder materials in the last two years concerned Li2O, Li4SiO4, Li2TiO3 and Li2ZrO3, with a clear emphasis on the development of Li2TiO3. Pebble-manufacturing processes have been developed up to a 10 kg scale. Characterisation of materials has advanced. A jump-wise progress is observed in the characterisation of pebble-beds, in particular of their thermo-mechanical behaviour. Thermal property data are still limited. A number of breeder materials have been or are being irradiated in material test reactors like HFR and JMTR. The EXOTIC-8 series of in-pile experiments is a major source of tritium release data. This paper discusses the technical advancements and proposes a focus for further research and development (R&D) : pebble-bed mechanical and thermal behaviour and its interactions with the blanket structure as a function of temperature, burn-up, irradiation dose and time; tritium release and retention properties; determination of the key factors limiting blanket life.

  7. [Recent progresses in RNA N6-methyladenosine research].

    PubMed

    Li, Yu-Li; Yu, Jun; Song, Shu-Hui

    2013-12-01

    RNA modifications, especially methylation of the N6 position of adenosine (A)--m6A, represent an emerging research territory in RNA biology. m6A is a post-transcriptional modification of RNAs, which is catalyzed by the mRNA: m6A methyltransferase complex containing three individual components and is the most common form found in the internal sequences of mRNAs in eukaryotes. Latest study showed that the fat mass and obesity-associated protein could remove the methyl group, indicating that the modification is reversible. Importantly, inhibiting or silencing the methyltransferase will cause significant changes of phenotypes. However, due to limited detection methods, the mechanism of m6A has not been figured out yet. Next-generation sequencing combining with IP (immunoprecipitation) technologies makes it possible to detect m6A modifications in a large scale. Here, we reviewed recent progresses of m6A studies including the discovery of m6A, mechanism of biosynthesis, tissue and genome distribution, detection methodology and possible biological functions. We also compared three IP-seq technologies that are currently widely used, and summarized the challenges in m6A studies. PMID:24645343

  8. Texas Experimental Tokamak, a plasma research facility: Technical progress report

    SciTech Connect

    Wootton, A.J.

    1995-08-01

    In the year just past, the authors made major progress in understanding turbulence and transport in both core and edge. Development of the capability for turbulence measurements throughout the poloidal cross section and intelligent consideration of the observed asymmetries, played a critical role in this work. In their confinement studies, a limited plasma with strong, H-mode-like characteristics serendipitously appeared and received extensive study though a diverted H-mode remains elusive. In the plasma edge, they appear to be close to isolating a turbulence drive mechanism. These are major advances of benefit to the community at large, and they followed from incremental improvements in diagnostics, in the interpretation of the diagnostics, and in TEXT itself. Their general philosophy is that the understanding of plasma physics must be part of any intelligent fusion program, and that basic experimental research is the most important part of any such program. The work here demonstrates a continuing dedication to the problems of plasma transport which continue to plague the community and are an impediment to the design of future devices. They expect to show here that they approach this problem consistently, systematically, and effectively.

  9. [Research progress on free radicals in human body].

    PubMed

    Wang, Q B; Xu, F P; Wei, C X; Peng, J; Dong, X D

    2016-08-10

    Free radicals are the intermediates of metabolism, widely exist in the human bodies. Under normal circumstances, the free radicals play an important role in the metabolic process on human body, cell signal pathway, gene regulation, induction of cell proliferation and apoptosis, so as to maintain the normal growth and development of human body and to inhibit the growth of bacteria, virus and cancer. However, when organic lesion occurs affected by external factors or when equilibrium of the free radicals is tipped in the human body, the free radicals will respond integratedly with lipids, protein or nucleic acid which may jeopardize the health of human bodies. This paper summarizes the research progress of the free radicals conducted in recent years, in relations to the perspective of the types, origins, test methods of the free radicals and their relationship with human's health. In addition, the possible mechanisms of environmental pollutants (such as polycyclic aromatic hydrocarbons) mediating oxidative stress and free radicals scavenging in the body were also summarized. PMID:27539355

  10. Progress and Prospect of Physics Research and Education in Taiwan

    NASA Astrophysics Data System (ADS)

    Raynien Kwo, J.

    2010-03-01

    Started about two decades ago, the global trend of shifting industrial manufacture power from western developed countries toward developing countries in Asia has in turn become the impetus in building up physical science and research in these areas. A very good example is the remarkable progress of physical research and education in Taiwan, in terms of quantity and quality. The continuous elevation of Taiwan's high education into graduate level plus the government's strong commitment to research and development on a level of 2.62 % GDP have led to an impressive physics program with an annual budget ˜32 million USD from National Science Council in supporting 568 PIs. The investigation scope encompasses high energy and astrophysics, nano and condensed matter, and semiconductor, optoelectronic physics, etc. The former is vigorously conducted via international collaborative efforts of LHC, KEK, ALMA, Pan-STARRS, etc. The latter is driven by vital Taiwan high tech industry mostly semiconductor IC and optoelectronics flourished during this period. The early trend of outflows of BS physics majors to western world for advanced studies has reversed dramatically. Nearly 80% of the BS students continue their MS and PhD degrees in Taiwan, attracted by lucrative job markets of high tech industry. In addition, healthy inflow of high-quality science manpower of well trained PhDs and senior scholars returning to homeland has strengthened the competitiveness. Overall, the physics community in Taiwan is thriving. The annual Physical Society meeting is expanding at a rate of 6%, reaching ˜1800 attendants and 1200 papers, and dedicated to promotions of female physicists and students. The publication quantity of Taiwan in top journals of PRs and PRL is ranked among top 20^th for all fields of physics, and ranked the 6^th in APL. Clearly Taiwan has now emerged as a strong power in applied science, not limited by its population size. Concerted efforts on scientific exchanges are being

  11. A Portfolio Analysis Tool for Measuring NASAs Aeronautics Research Progress toward Planned Strategic Outcomes

    NASA Technical Reports Server (NTRS)

    Tahmasebi, Farhad; Pearce, Robert

    2016-01-01

    Description of a tool for portfolio analysis of NASA's Aeronautics research progress toward planned community strategic Outcomes is presented. The strategic planning process for determining the community Outcomes is also briefly described. Stakeholder buy-in, partnership performance, progress of supporting Technical Challenges, and enablement forecast are used as the criteria for evaluating progress toward Outcomes. A few illustrative examples are also presented.

  12. Thermonuclear Fusion Research Progress and the Way to the Reactor

    NASA Astrophysics Data System (ADS)

    Koch, Raymond

    2006-06-01

    The paper reviews the progress of fusion research and its prospects for electricity generation. It starts with a reminder of the principles of thermonuclear fusion and a brief discussion of its potential role in the future of the world energy production. The reactions allowing energy production by fusion of nuclei in stars and on earth and the conditions required to sustain them are reviewed. At the high temperatures required for fusion (hundred millions kelvins), matter is completely ionized and has reached what is called its 4th state: the plasma state. The possible means to achieve these extreme temperatures is discussed. The remainder of the paper focuses on the most promising of these approaches, magnetic confinement. The operating principles of the presently most efficient machine of this type — the tokamak — is described in some detail. On the road to producing energy with fusion, a number of obstacles have to be overcome. The plasma, a fluid that reacts to electromagnetic forces and carries currents and charges, is a complex medium. Fusion plasma is strongly heated and is therefore a good example of a system far from equilibrium. A wide variety of instabilities can grow in this system and lead to self-organized structures and spontaneous cycles. Turbulence is generated that degrades the confinement and hinders easy achievement of long lasting hot plasmas. Physicists have learned how to quench turbulence, thereby creating sort of insulating bottles inside the plasma itself to circumvent this problem. The recent history of fusion performance is outlined and the prospect of achieving power generation by fusion in a near future is discussed in the light of the development of the "International Tokamak Experimental Reactor" project ITER.

  13. [Research progress of microbial haloalkane dehalogenase--a review].

    PubMed

    Li, Anzhang; Shao, Zongze

    2015-04-01

    Haloalkane dehalogenases are key enzymes for biodegradation of halogenated aliphatic compounds, widely distributed in various microbial species of wide geographical distributions, and of significance in practical application such as bioremediation and industrial biocatalysis. Twenty haloalkane dehalogenases have been biochemically characterized so far. In recent years, progresses have been made in the enzymatic characteristics, protein structures, and phylogenetic diversity. We reviewed the progresses of haloalkane dehalogenase in structure and function, diversity and application potential. PMID:26211311

  14. The Organization and Management of Interdisciplinary Research, A Progress Report.

    ERIC Educational Resources Information Center

    Birnbaum, Philip H.

    1982-01-01

    A discussion of the state of interdisciplinary research (IDR) in academia, government, and industry in North America and Europe focuses on current issues and themes, organizational structure, researchers, input-output processes, the process of IDR, outputs, and future research needs. Descriptive research on IDR and normative research for…

  15. Collisional processes of interest in the MFE plasma research. Progress report No. 1

    SciTech Connect

    Olson, R E

    1980-01-31

    Research on this contract can be divided into two general topics: (1) D/sup -/ formation collision processes, and (2) the determination of scattering cross sections used to diagnose plasma properties. Research progress during the last four months is presented.

  16. Advanced Reactor Safety Research Division. Quarterly progress report, January 1-March 31, 1980

    SciTech Connect

    Agrawal, A.K.; Cerbone, R.J.; Sastre, C.

    1980-06-01

    The Advanced Reactor Safety Research Programs quarterly progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the USNRC Division of Reactor Safety Research. The projects reported each quarter are the following: HTGR Safety Evaluation, SSC Code Development, LMFBR Safety Experiments, and Fast Reactor Safety Code Validation.

  17. [The research progress of transcatheter aortic valve replacement].

    PubMed

    Cheng, Maobo; Shi, Xinli; Jia, Jianxiong; Miao, Jingjing; Liu, Wei; Nie, Feilong

    2014-09-01

    During the past years transcatheter aortic valve replacement has evolved to a promising technique for the treatment of the patients who suffered from severe aortic stenosis, the progress and basic consideration on clinical study have been summarized in the article. PMID:25597083

  18. Research program in elementary-particle theory, 1983. Progress report

    SciTech Connect

    Sudarshan, E C.G.; Ne'eman, Y

    1983-08-01

    Progress is reviewed on the following topics: physics of ultra high energies and cosmology; phenomenology of particle physics; quantum field theory, supersymmetry and models of particles; and geometric formulations and algebraic models. Recent DOE reports resulting from the contract are listed. (WHK)

  19. A Year of Unprecedented Progress in Down Syndrome Basic Research

    ERIC Educational Resources Information Center

    Reeves, Roger H.; Garner, Craig C.

    2007-01-01

    The years 2006 and 2007 saw the publication of three new and different approaches to prevention or amelioration of Down syndrome effects on the brain and cognition. We describe the animal model systems that were critical to this progress, review these independent breakthrough studies, and discuss the implications for therapeutic approaches…

  20. Research on Automatic Classification, Indexing and Extracting. Annual Progress Report.

    ERIC Educational Resources Information Center

    Baker, F.T.; And Others

    In order to contribute to the success of several studies for automatic classification, indexing and extracting currently in progress, as well as to further the theoretical and practical understanding of textual item distributions, the development of a frequency program capable of supplying these types of information was undertaken. The program…

  1. Beyond Constructivism: The Progressive Research Programme into Learning Science

    ERIC Educational Resources Information Center

    Taber, Keith S.

    2006-01-01

    In this paper, it is suggested that while there are a variety of frames or perspectives that guide research into learning science, a pre-paradigmatic field need not be a "free-for-all". Lakatos suggested that academic research fields were characterised by research programmes (RP), which offered heuristic guidance to researchers, and which…

  2. FY2011 Progress Report for Energy Storage Research & Development

    SciTech Connect

    none,

    2012-01-31

    The FY 2011 Progress Report for Energy Storage R&D focuses on advancing the development of batteries to enable a large market penetration of hybrid and electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush.

  3. [Research progress on molecular genetics of male homosexuality].

    PubMed

    Tu, Dan; Xu, Ruiwei; Zhao, Guanglu; Wang, Binbin; Feng, Tiejian

    2016-08-01

    Sexual orientation is influenced by both environmental factors and biological factors. Family and twin studies have shown that genetic factors play an important role in the formation of male homosexuality. Genome-wide scan also revealed candidate chromosomal regions which may be associated with male homosexuality, but so far no clearly related genes have been found. This article reviews the progress of relevant studies and candidate genes which are related to male homosexuality. PMID:27455023

  4. Recent Progress on Nutraceutical Research in Prostate Cancer

    PubMed Central

    Li, Yiwei; Ahmad, Aamir; Kong, Dejuan; Bao, Bin; Sarkar, Fazlul H.

    2014-01-01

    Recently, nutraceuticals have received increasing attention as the agents for cancer prevention and supplement with conventional therapy. Prostate Cancer (PCa) is most frequently diagnosed cancer and second leading cause of cancer-related death in men in US. Growing evidences from epidemiological studies, in vitro experimental studies, animal studies, and clinical trials have shown that nutraceuticals could be very useful for the prevention and treatment of PCa. Several nutraceuticals including isoflavone, indole-3-carbinol, 3,3’-diindolylmethane, lycopene, (-)-epigallocatechin-3-gallate, and curcumin are known to down-regulate the signal transductions in AR, Akt, NF-κB, and other signal transduction pathways which are vital for the development of PCa and the progression of PCa from androgen-sensitive to castrate-resistant PCa. Therefore, nutraceutical treatment in combination with conventional therapeutics could achieve better treatment outcome in prostate cancer therapy. Interestingly, some nutraceuticals could regulate the function of cancer stem cell (CSC) related miRNAs and associated molecules, leading to the inhibition of prostatic CSCs which are responsible for drug-resistance, tumor progression, and recurrence of PCa. Hence, nutraceuticals may serve as powerful agents for the prevention of PCa progression and they could also be useful in combination with chemotherapeutics or radiotherapy. Such strategy could become a promising newer approach for the treatment of metastatic PCa with better treatment outcome by improving overall survival. PMID:24375392

  5. Research on Speech Perception. Progress Report No. 12.

    ERIC Educational Resources Information Center

    Pisoni, David B.; And Others

    Summarizing research activities in 1986, this is the twelfth annual report of research on speech perception, analysis, synthesis, and recognition conducted in the Speech Research Laboratory of the Department of Psychology at Indiana University. The report contains the following 23 articles: "Comprehension of Digitally Encoded Natural Speech Using…

  6. Research on Speech Perception. Progress Report No. 15.

    ERIC Educational Resources Information Center

    Pisoni, David B.

    Summarizing research activities in 1989, this is the fifteenth annual report of research on speech perception, analysis, synthesis, and recognition conducted in the Speech Research Laboratory of the Department of Psychology at Indiana University. The report contains the following 21 articles: "Perceptual Learning of Nonnative Speech Contrasts:…

  7. Development and Progression of a Model: Prospective Research Compliance Monitoring

    ERIC Educational Resources Information Center

    Fedor, Carol; Ferrazzano Yaussy, Cristina; Cola, Philip A.

    2008-01-01

    Recent trends in Human Research Protection Programs (HRPPs) have contributed to the rising emphasis on prospective monitoring of clinical research and education programs. Therefore, internal efforts and resources to monitor investigator compliance and site performance have become an important focus in the conduct of clinical research. Once the…

  8. Marine research in Greece and the additional Greek marine research centres: Progress and present situation

    NASA Astrophysics Data System (ADS)

    Haritonidis, S.

    1995-03-01

    Greece, as is known, has a coastline of 17 000 km, and over 2000 small and large islands. As expected, the quest of humankind for new sources of matter and energy has been focussed on the sea, with fishery being its primary interest. A number of philosophers and scientists have been involved in the study of this vast ecosystem since ancient times (Aristotle). The political, social and geographical upheavals witnessed in the Greek area, have, however resulted in bringing all these activities to a halt. The first contemporary research work commenced at the end of the 18th century/beginning of the 19th — with marine flora and fauna as its starting point. The first investigations had, of course, been limited to random collections of marine material done in the frame of international exploratory expeditions. Studies became more systematic by the end of the 19th and beginning of the 20th century, with priority being given to the animal kingdom (fish, molluscs, etc.). Investigation of the marine phytobenthos (macrophyceae, phytoplankton) was to follow. The past 40 years research has been more extensive, not limited only to biogeographical evaluations, but also having expanded to physiological and ecological levels. The relevant institutes of Greek universities have all the while watched and contributed to this effort. Today, this kind of research is being supported by the N.M.R.C., the Center of Marine Research, University of Crete, and two research boats which sail the Greek seas. In the ever-changing world, the study of marine flora and fauna has certainly made great progress; however, there are still two big problems to be faced. The first deals with increasing pollution of the seas, the second, with the difficulties in finding and affording adequate financial resources that would enable a more detailed and complete execution of this research work.

  9. Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, January 1--March 31, 1989

    SciTech Connect

    Weiss, A.J.

    1989-08-01

    This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems Research of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through December 31, 1988.

  10. Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, October 1--December 31, 1988

    SciTech Connect

    Weiss, A J; Azarm, A; Baum, J W; Boccio, J L; Carew, J; Diamond, D J; Fitzpatrick, R; Ginsberg, T; Greene, G A; Guppy, J G; Haber, S B

    1989-07-01

    This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems Research of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through September 30, 1988.

  11. Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, January 1--June 30, 1988

    SciTech Connect

    Baum, J W; Boccio, J L; Diamond, D; Fitzpatrick, R; Ginsberg, T; Greene, G A; Guppy, J G; Hall, R E; Higgins, J C; Weiss, A J

    1988-12-01

    This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems Research of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through December 31, 1987.

  12. Progress in amorphous silicon multijunction research at solarex

    SciTech Connect

    Arya, R.R.; Carlson, D.E.; Yang, L.; Chen, L.F.; Willing, F.; Rajan, K.; Jansen, K.; Poplawski, C.; Bradley, D.; Wood, G.

    1997-02-01

    Large strides have been made at Solarex inadvancing amorphous silicon multijunction technology to a maturity level where large-area commercial modules are technically and economically viable. Tandem junction modules (4ft{sup 2}) have been demonstrated with average stabilized efficiency of 8{percent}. While maintaining stabilized efficiency the a-Si alloy deposition time has been reduced by 28{percent} and the material usage reduced by 38{percent}. Progress has also been made in understanding and improving ZnO front contact and stability. {copyright} {ital 1997 American Institute of Physics.}

  13. Accelerating Regulatory Progress in Multi-Institutional Research

    PubMed Central

    Paolino, Andrea R.; Lauf, Sherry Lee; Pieper, Lisa E.; Rowe, Jared; Vargas, Ileana M.; Goff, Melissa A.; Daley, Matthew F.; Tuzzio, Leah; Steiner, John F.

    2014-01-01

    Purpose: Multi-institutional collaborations are necessary in order to create large and robust data sets that are needed to answer important comparative effectiveness research (CER) questions. Before scientific work can begin, a complex maze of administrative and regulatory requirements must be efficiently navigated to avoid project delays. Innovation: Staff from research, regulatory, and administrative teams involved in three HMO Research Network (HMORN) multi-institutional collaborations developed and employed novel approaches: to secure and maintain Institutional Review Board (IRB) approvals; to enable data sharing, and to expedite subawards for two data-only minimal risk studies. These novel approaches accelerated required processes and approvals while maintaining regulatory, human subjects, and institutional protections. Credibility: Outcomes from the processes described here are compared with processes outlined in the research and regulatory literature and with processes that have been used in previous multisite research collaborations. Conclusion and Discussion: Research, regulatory, and administrative staff are essential contributors to the success of multi-institutional collaborations. Their flexibility, creativity, and effective communication skills can lead to the development of efficient approaches to achieving the necessary oversight for these complex projects. Elements of these specific strategies can be adapted and used by other research networks. Other efforts in these areas should be evaluated and shared. The processes that help develop a “learning research system” play an important and complementary role in sustaining multi-institutional research collaborations. PMID:25848593

  14. Laboratory directed research and development. FY 1995 progress report

    SciTech Connect

    Vigil, J.; Prono, J.

    1996-03-01

    This document presents an overview of Laboratory Directed Research and Development Programs at Los Alamos. The nine technical disciplines in which research is described include materials, engineering and base technologies, plasma, fluids, and particle beams, chemistry, mathematics and computational science, atmic and molecular physics, geoscience, space science, and astrophysics, nuclear and particle physics, and biosciences. Brief descriptions are provided in the above programs.

  15. 2002 Gordon Research Conference on CATALYSIS. Final Progress Report

    SciTech Connect

    2002-06-28

    The Gordon Research Conference (GRC) on CATALYSIS was held at Colby-Sawyer College from 6/23/02 thru 6/28/02. The Conference was well-attended with 118 participants. The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students.

  16. 2002 Gordon Research Conference on Mutagenesis. Final Progress Report

    SciTech Connect

    2002-08-02

    The Gordon Research Conference (GRC) on MUTAGENESIS was held at Bates College from 7/28/02 thru 8/2/02. The Conference was well-attended with 157 participants. The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students.

  17. Practice and Progression in Second Language Research Methods

    ERIC Educational Resources Information Center

    Mackey, Alison

    2014-01-01

    Since its inception, the field of second language research has utilized methods from a number of areas, including general linguistics, psychology, education, sociology, anthropology and, recently, neuroscience and corpus linguistics. As the questions and objectives expand, researchers are increasingly pushing methodological boundaries to gain a…

  18. Research on Youth Violence: Progress by Replacement, Not Addition.

    ERIC Educational Resources Information Center

    Hoagwood, Kimberly

    2000-01-01

    This article discusses the need to concentrate more educational research into efficacy studies on the effectiveness of specific preventive and treatment interventions targeted at disruptive behavior disorders. Other research needs are highlighted such as underlying mechanisms by which aggressive behavior develops, involvement in gangs, positive…

  19. UCLA Particle Physics Research Group annual progress report

    SciTech Connect

    Nefkens, B.M.K.

    1983-11-01

    The objectives, basic research programs, recent results, and continuing activities of the UCLA Particle Physics Research Group are presented. The objectives of the research are to discover, to formulate, and to elucidate the physics laws that govern the elementary constituents of matter and to determine basic properties of particles. The research carried out by the Group last year may be divided into three separate programs: (1) baryon spectroscopy, (2) investigations of charge symmetry and isospin invariance, and (3) tests of time reversal invariance. The main body of this report is the account of the techniques used in our investigations, the results obtained, and the plans for continuing and new research. An update of the group bibliography is given at the end.

  20. Research progress and accomplishments on International Space Station

    NASA Technical Reports Server (NTRS)

    Roe, Lesa B.; Uri, John J.

    2003-01-01

    The first research payloads reached the International Space Station (ISS) more than two years ago, with research operating continuously since March 2001. Seven research racks are currently on-orbit, with three more arriving soon to expand science capabilities. Through the first five expeditions, 60 unique NASA-managed investigations from 11 nations have been supported, many continuing into later missions. More than 90,000 experiment hours have been completed, and more than 1,000 hours of crew time have been dedicated to research, numbers that grow daily. The multidisciplinary program includes research in life sciences, physical sciences, biotechnology, Earth sciences, technology demonstrations as well as commercial endeavors and educational activities. The Payload Operations and Integration Center monitors the onboard activities around the clock, working with numerous Principal Investigators and Payload Developers at their remote sites. Future years will see expansion of the station with research modules provided by the European Space Agency and Japan, which will be outfitted with additional research racks. c2003 American Institute of Aeronautics and Astronautics. Published by Elsevier Science Ltd. All rights reserved.

  1. Research progress and accomplishments on International Space Station.

    PubMed

    Roe, Lesa B; Uri, John J

    2003-01-01

    The first research payloads reached the International Space Station (ISS) more than two years ago, with research operating continuously since March 2001. Seven research racks are currently on-orbit, with three more arriving soon to expand science capabilities. Through the first five expeditions, 60 unique NASA-managed investigations from 11 nations have been supported, many continuing into later missions. More than 90,000 experiment hours have been completed, and more than 1,000 hours of crew time have been dedicated to research, numbers that grow daily. The multidisciplinary program includes research in life sciences, physical sciences, biotechnology, Earth sciences, technology demonstrations as well as commercial endeavors and educational activities. The Payload Operations and Integration Center monitors the onboard activities around the clock, working with numerous Principal Investigators and Payload Developers at their remote sites. Future years will see expansion of the station with research modules provided by the European Space Agency and Japan, which will be outfitted with additional research racks. PMID:14649287

  2. Environmental Research Division technical progress report: January 1986--October 1987

    SciTech Connect

    Not Available

    1988-07-01

    Technical process in the various research activities of Argonne National Laboratory's Environmental Research Division is reported for the period 1986-1987. Textual, graphic, and tabular information is used to briefly summarize (in separate chapters) the work of the Division's Atmospheric Physics, Environmental Effects Research, Fundamental Molecular Physics and Chemistry, and Organic Geochemistry and Environmental Instrumentation Programs. Information on professional qualifications, awards, and outstanding professional activities of staff members, as well as lists of publications, oral presentations, special events organized, and participants in educational programs, are provided in appendices at the end of each chapter. Individual projects under each division are processed separately for the data bases.

  3. Experimental progress in magnetic-mirror fusion research

    NASA Astrophysics Data System (ADS)

    Simonen, T. C.

    1981-08-01

    This paper discusses experimental progress in the control, confinement, and understanding of magnetic-mirror confined plasmas. A summary is given of the data base established in previous experiments on which magnetic-mirror principles are based. It includes a detailed description of present tandem and field-reversed mirror experimental results. The discussion also includes the concepts and parameters of experiments now under construction; it is shown how these experiments can both test new thermal-barrier concepts and bridge the gap between existing facilities and eventual power producers. Consideration is given to small-scale physics-oriented experiments, aimed at testing new ideas and refining the knowledge of mirror confinement. The paper concludes with an extensive bibliography of reports from the field of magnetic-mirror fusion.

  4. [Research progress of tumor infiltrating lymphocytes in breast cancer].

    PubMed

    Huang, Jiahui; Chen, Xiaosong; Shen, Kunwei

    2015-09-01

    Breast cancer is a heterogeneous disease. The formation and progression of tumor and the sensitivity to treatment differs from patient to patient. In addition to the widely used molecular subtype, novel markers are needed to better personalize the treatment of breast cancer. Tumor infiltrating lymphocyte (TIL) have been consistently documented in breast cancer lesions especially in triple negative and human epidermal growth factor receptor-2 positive breast cancer. Several clinical trials have revealed that TIL are associated with prognosis and can predict therapeutic efficacy of special therapy. TIL could be divided to different subtypes including CD8 + TIL, CD4 + TIL, cytotoxic T lymphocyte-associated antigen-4 + TIL, programmed death-1 + TIL. They play different roles in the process of anti-tumor immunity and can predict different prognosis. Screening out special TIL subtype which is well associated with prognosis and therapeutic efficacy and developing targeting immunotherapy can help to improve outcomes of breast cancer patients. PMID:26654152

  5. Recent progress in cloud physics research in China

    NASA Astrophysics Data System (ADS)

    Ma, Jianzhong; Guo, Xueliang; Zhao, Chunsheng; Zhang, Yijun; Hu, Zhijin

    2007-11-01

    A review of China cloud physics research during 2003 2006 is made in this paper. The studies on cloud field experiments and observation, cloud physics and precipitation, including its theoretical applications in hail suppression and artificial rain enhancement, cloud physics and lightning, and clouds and climate change are included. Due primarily to the demand from weather modification activities, the issue of cloud physics and weather modification has been addressed in China with many field experiments and model studies. While cloud physics and weather modification is still an important research field, the interaction between aerosol, cloud and radiation processes, which is the key issue of current climate change research, has become a new research direction in China over the past four years.

  6. Progress in materials and structures at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Glasgow, T. K.; Lauver, R. W.; Halford, G. R.; Davies, R. L.

    1980-01-01

    The development of power and propulsion system technology is discussed. Specific emphasis is placed on the following: high temperature materials; composite materials; advanced design and life prediction; and nondestructive evaluation. Future areas of research are also discussed.

  7. [Pharmaceutical research progress of rhynchophylla based on chemical stability].

    PubMed

    Hao, Bo; Yang, Xiu-Juan; Feng, Yi; Hong, Yan-Long

    2014-12-01

    Rhynchophylla is a Chinese herb commonly used in clinical practice. It's also the primary herb of some famous Chinese herbal compound such as Tianma Gouteng decoction, and Lingyang Gouteng decoction. According the record from many previous materia medica literatures, rhynchophylla should be added later during decoction. Pharmaceutical research showed that rhynchophylla alkaloids were not stable. Which has resulted in many problems in the research and its application. For example, there was not a quantitative determination method in "Chinese Pharmacopoeia" of past and present versions, which seriously impacted its quality control and product application. Firstly, records from previous materia medica literatures and "Chinese Pharmacopoeia" were systematically sorted based on the chemical stability of rhynchophylla. Secondly, pharmaceutical research including chemical compositions and their stability, pharmacological effects, extraction process and quality analysis, was reviewed after reference of literatures published at home and abroad in recent decades. Positive reference and evidence for further research and development of rhynchophylla will be provided in the article. PMID:25911796

  8. Progress through Collaboration - Office of Cancer Clinical Proteomics Research

    Cancer.gov

    The National Cancer Institute (NCI), through the Office of Cancer Clinical Proteomics Research (OCCPR), has signed two Memorandums of Understanding (MOUs) in the areas of sharing proteomics reagents and protocols and also in regulatory science.

  9. RESEARCH PROGRESS AND HARDWARE SYSTEMS AT DIII-D

    SciTech Connect

    PETERSEN,P.I; THE DIII-D TEAM

    2003-10-01

    OAK-B135 During the last two years significant progress has been made in the scientific understanding of DIII-D plasmas. Much of this progress has been enabled by the addition of new hardware systems. The electron cyclotron (EC) system has been upgraded from 3 MW to 6 MW, by adding three 1 MW gyrotrons with diamond windows and three steerable launchers (PPPL). The new gyrotrons have been tested to 1.0 MW for 5 s. The system has been used to control the 3/2 and 2/1 neoclassical tearing modes and to locally heat the plasma and thereby indirectly control the current density. Electron cyclotron current drive ECCD has been used to directly affect the current density. A Li-beam diagnostic has been brought on-line for measuring the edge current density using Zeeman splitting. A set of 12 coils (1-coils), consisting of six picture frame coils each above and below the midplane, with a capability of 7 kA for 10 s has been installed inside the DIII-D vessel. These coils, along with the existing six C-coils, are used to apply non-axisymmetric fields to the plasma for both exciting and controlling plasma instabilities. The DIII-D digital plasma control system is now used to not just control the shape and location of the plasma but also the electron temperature, density, the NTMs, RWMs, plasma beta and disruption mitigation. Plasma disruption experiments are extended to mitigation of real time detected disruptions on DIII-D.

  10. UCLA Particle and Nuclear Physics Research Group, 1993 progress report

    SciTech Connect

    Nefkens, B.M.K.; Clajus, M.; Price, J.W.; Tippens, W.B.; White, D.B.

    1993-09-01

    The research programs of the UCLA Particle and Nuclear Physics Research Group, the research objectives, results of experiments, the continuing activities and new initiatives are presented. The primary goal of the research is to test the symmetries and invariances of particle/nuclear physics with special emphasis on investigating charge symmetry, isospin invariance, charge conjugation, and CP. Another important part of our work is baryon spectroscopy, which is the determination of the properties (mass, width, decay modes, etc.) of particles and resonances. We also measure some basic properties of light nuclei, for example the hadronic radii of {sup 3}H and {sup 3}He. Special attention is given to the eta meson, its production using photons, electrons, {pi}{sup {plus_minus}}, and protons, and its rare and not-so-rare decays. In Section 1, the physics motivation of our research is outlined. Section 2 provides a summary of the research projects. The status of each program is given in Section 3. We discuss the various experimental techniques used, the results obtained, and we outline the plans for the continuing and the new research. Details are presented of new research that is made possible by the use of the Crystal Ball Detector, a highly segmented NaI calorimeter and spectrometer with nearly 4{pi} acceptance (it was built and used at SLAC and is to be moved to BNL). The appendix contains an update of the bibliography, conference participation, and group memos; it also indicates our share in the organization of conferences, and gives a listing of the colloquia and seminars presented by us.

  11. Maryland controlled fusion research program. Progress report, November 1, 1991--October 31, 1992

    SciTech Connect

    Griem, H.R.; Liu, C.S.

    1992-07-01

    In this paper, we summarize the technical progress in four major areas of tokamak research: (a) L/H transition and edge turbulence and transport; (b) active control of microturbulence and transport; (c) major disruptions; and (d) the sawtooth crash.

  12. Supporting Progressive Change: The James R. Squire Office of Policy Research

    ERIC Educational Resources Information Center

    Farrell, Edmund J.

    2004-01-01

    The NCTE has established a center of policy research to honor the legacy of James R. Squire in order to support progressive reform in English language arts education. James R. Squire's life and work are discussed in detail.

  13. Health and Safety Research Division progress report, July 1, 1984-September 30, 1985

    SciTech Connect

    Not Available

    1986-01-01

    This report summarizes progress made for the period July 1984 through September 1985. Sections describe research in health studies, dosimetry and biophysical transport, biological and radiation physics, chemical physics, and risk analysis. (ACR)

  14. Contracts for field projects and supporting research on enhanced oil recovery. Progress review No. 89

    SciTech Connect

    1998-04-01

    Summaries are presented for the DOE contracts related to supported research for thermal recovery of petroleum, geoscience technology, and field demonstrations in high-priority reservoir classes. Data included for each project are: title, contract number, principal investigator, research organization, beginning date, expected completion date, amount of award, objectives of the research, and summary of technical progress.

  15. Research on Speech Perception. Progress Report No. 9, January 1983-December 1983.

    ERIC Educational Resources Information Center

    Pisoni, David B.; And Others

    Summarizing research activities from January 1983 to December 1983, this is the ninth annual report of research on speech perception, analysis and synthesis conducted in the Speech Research Laboratory of the Department of Psychology at Indiana University. The report includes extended manuscripts, short reports, and progress reports. The report…

  16. Research in Progress--Update April 1990. Occasional Paper InTER/14/90.

    ERIC Educational Resources Information Center

    Boots, Maureen, Comp.

    This document contains abstracts of 29 research projects in progress in Great Britain divided into six sections: (1) the current phase of Information Technology in Education Research (InTER) programs on groupwork with computers, tools for exploratory learning, conceptual change in science, and bubble dialogue as an ethnographic research tool; (2)…

  17. Research Results Ultra-fast Energy Transfer from Monomer to Dimer within a Trimeric Molecule New Progress in Heterogeneous Catalysis Research Key Progress in Research on Terrestrial Carbon Cycle in China A New Progress in Research on the Mechanism of Bio-Invasion New Findings in Anti-viral infection and Control of Inflammation Major Headway in Avian Origin Research New Progress in Gold-Nanoparticle-Based Biochips Topological Insulator Research Made Important Progress Major Progress in Biodiversity Achieved New Developments of Direct Methods in Protein Crystallography Major Progress in China-UK Collaboration on the Causal Relationship between Volcanic Activity and Biological Distinction News in Brief: NSFC set up "Research Fund for Young Foreign Scholars" How Often Does Human DNA Mutate? Research Progress on Colossal Anisotropic Magneto Resistive Effect

    NASA Astrophysics Data System (ADS)

    2009-01-01

    Ultra-fast Energy Transfer from Monomer to Dimer within a Trimeric Molecule New Progress in Heterogeneous Catalysis Research Key Progress in Research on Terrestrial Carbon Cycle in China A New Progress in Research on the Mechanism of Bio-Invasion New Findings in Anti-viral infection and Control of Inflammation Major Headway in Avian Origin Research New Progress in Gold-Nanoparticle-Based Biochips Topological Insulator Research Made Important Progress Major Progress in Biodiversity Achieved New Developments of Direct Methods in Protein Crystallography Major Progress in China-UK Collaboration on the Causal Relationship between Volcanic Activity and Biological Distinction News in Brief: NSFC set up "Research Fund for Young Foreign Scholars" How Often Does Human DNA Mutate? Research Progress on Colossal Anisotropic Magneto Resistive Effect

  18. Research in progress: FY 1992. Summaries of projects

    SciTech Connect

    Not Available

    1993-08-01

    The Biological and Environmental Research (BER) Program of OHER has two main missions: (1) to develop the knowledge base necessary to identify, understand, and anticipate the long-term health and environmental consequences of energy use and development and (2) to utilize the Department`s unique scientific and technological capabilities to solve major scientific problems in medicine, biology, and the environment. These missions reflect a commitment to develop the beneficial uses of advanced energy technologies while at the same time assuring that any potentially adverse health and environmental impacts of the Nation`s energy policies are fully identified and understood. The BER Program includes research in atmospheric, marine, and terrestrial processes, including the linkage between the use in greenhouse gases, carbon dioxide, and regional and global climate change; in molecular and subcellular mechanisms underlying human somatic and genetic processes and their responses to energy-related environmental toxicants; in nuclear medicine, structural biology, the human genome, measurement sciences and instrumentation, and other areas that require the unique capabilities of the Department`s laboratory system. The principal areas of research are Health Research and Environmental Research.

  19. Theory, Modeling and Simulation: Research progress report 1994--1995

    SciTech Connect

    Garrett, B.C.; Dixon, D.A.; Dunning, T.H.

    1997-01-01

    The Pacific Northwest National Laboratory (PNNL) has established the Environmental Molecular Sciences Laboratory (EMSL). In April 1994, construction began on the new EMSL, a collaborative research facility devoted to advancing the understanding of environmental molecular science. Research in the Theory, Modeling, and Simulation (TM and S) program will play a critical role in understanding molecular processes important in restoring DOE`s research, development, and production sites, including understanding the migration and reactions of contaminants in soils and ground water, developing processes for isolation and processing of pollutants, developing improved materials for waste storage, understanding the enzymatic reactions involved in the biodegradation of contaminants, and understanding the interaction of hazardous chemicals with living organisms. The research objectives of the TM and S program are fivefold: to apply available electronic structure and dynamics techniques to study fundamental molecular processes involved in the chemistry of natural and contaminated systems; to extend current electronic structure and dynamics techniques to treat molecular systems of future importance and to develop new techniques for addressing problems that are computationally intractable at present; to apply available molecular modeling techniques to simulate molecular processes occurring in the multi-species, multi-phase systems characteristic of natural and polluted environments; to extend current molecular modeling techniques to treat ever more complex molecular systems and to improve the reliability and accuracy of such simulations; and to develop technologies for advanced parallel architectural computer systems. Research highlights of 82 projects are given.

  20. Exploratory energy research program at the University of Michigan. Progress report

    SciTech Connect

    Kerr, W.

    1980-12-08

    A DOE grant to the University of Michigan for an Exploratory Energy Research Program is being used by the U-M Office of Energy Research (OER) to support faculty research and grad student research assistantships. Progress on activity during the first six months of the program is described and brief status reports on 20 energy-related faculty research projects in the physical, engineering, biological, and behavioral sciences are presented.

  1. Recent Progress on Sonic Boom Research at NASA

    NASA Technical Reports Server (NTRS)

    Loubeau, Alexandra

    2012-01-01

    Sonic boom research conducted at NASA through the Supersonics Project of the Fundamental Aeronautics Program is oriented toward understanding the potential impact of sonic boom noise on communities from new low-boom supersonic aircraft designs. Encompassing research in atmospheric propagation, structural response, and human response, NASA research contributes to knowledge in key areas needed to support development of a new noise-based standard for supersonic aircraft certification. Partnerships with several industry, government, and academic institutions have enabled the recent execution of several acoustic field studies on sonic booms. An overview of recent activities funded by NASA includes: focus boom model development and experimental validation, field experiments of structural transmission of sonic booms into large buildings, and low boom community response testing.

  2. Research in actinide chemistry. Progress report, 1990--1993

    SciTech Connect

    Choppin, G.R.

    1993-04-01

    This research studies the behavior of the actinide elements in aqueous solution. The high radioactivity of the transuranium actinides limits the concentrations which can be studied and, consequently, limits the experimental techniques. However, oxidation state analogs (trivalent lanthanides, tetravalent thorium, and hexavalent uranium) do not suffer from these limitations. Behavior of actinides in the environment are a major USDOE concern, whether in connection with long-term releases from a repository, releases from stored defense wastes or accidental releases in reprocessing, etc. Principal goal of our research was expand the thermodynamic data base on complexation of actinides by natural ligands (e.g., OH{sup {minus}}, CO{sub 3}{sup 2{minus}}, PO{sub 4}{sup 3{minus}}, humates). The research undertakes fundamental studies of actinide complexes which can increase understanding of the environmental behavior of these elements.

  3. Laboratory-directed research and development: FY 1996 progress report

    SciTech Connect

    Vigil, J.; Prono, J.

    1997-05-01

    This report summarizes the FY 1996 goals and accomplishments of Laboratory-Directed Research and Development (LDRD) projects. It gives an overview of the LDRD program, summarizes work done on individual research projects, and provides an index to the projects` principal investigators. Projects are grouped by their LDRD component: Individual Projects, Competency Development, and Program Development. Within each component, they are further divided into nine technical disciplines: (1) materials science, (2) engineering and base technologies, (3) plasmas, fluids, and particle beams, (4) chemistry, (5) mathematics and computational sciences, (6) atomic and molecular physics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) biosciences.

  4. [Research progress on emotion recognition based on physiological signals].

    PubMed

    Zhang, Di; Wan, Baikun; Ming, Dong

    2015-02-01

    Emotion recognition will be prosperious in multifarious applications, like distance education, healthcare, and human-computer interactions, etc. Emotions can be recognized from the behavior signals such as speech, facial expressions, gestures or the physiological signals such as electroencephalogram and electrocardiogram. Contrast to other methods, the physiological signals based emotion recognition can achieve more objective and effective results because it is almost impossible to be disguised. This paper introduces recent advancements in emotion research using physiological signals, specified to its emotion model, elicitation stimuli, feature extraction and classification methods. Finally the paper also discusses some research challenges and future developments. PMID:25997298

  5. Follicular transport route--research progress and future perspectives.

    PubMed

    Knorr, Fanny; Lademann, Jürgen; Patzelt, Alexa; Sterry, Wolfram; Blume-Peytavi, Ulrike; Vogt, Annika

    2009-02-01

    The important role of hair follicles as penetration pathways and reservoir structures for topically applied compounds has been validated in numerous animal models as well as in humans. Follicular penetration rates are modulated by regional variations in size and proportions and the functional status. Advances have especially been made in the targeting of hair follicle-associated cell populations including antigen-presenting cells and stem cells. Improved investigative methods based on differential stripping, spectrophotometry and confocal laser scanning microscopy have led to the determination of the penetration profiles and kinetics for a multiplicity of drugs and drug delivery systems. The observation that particulate delivery systems aggregate and remain in hair follicle openings and their penetration along the follicular duct occurs in a size-dependent manner, which has led to advanced concepts of targeted drug delivery of bioactive compounds in the field of solid particles, as well as semi-solid particles, such as liposomes. This review summarizes the recent progress in this field, and underlines the necessity for pilot studies in human volunteers to further the development of clinical applications for follicular targeting. PMID:19041720

  6. [Low grade lymphoma: research progress and questions about treatment].

    PubMed

    Ishizawa, Kenichi

    2015-10-01

    Treatment options for follicular lymphoma (FL) are considered when patients have limited stage, low tumor burden advanced stage, and high tumor burden advanced stage disease. Although patients with limited stage FL are managed with radiotherapy (24-36 Gy), watchful waiting (WW), rituximab monotherapy, and rituximab combined with chemotherapy need to be evaluated. In patients with low tumor burdens, WW is regarded as the standard management. The usefulness of rituximab monotherapy was also recently suggested. Rituximab combined with chemotherapy improved overall survival (OS) in patients with high tumor burdens and the optimal reference regimen might be R-CHOP or rituximab combined with bendamustine. As to efficacy, improved relapse-free survival, with rituximab maintenance, has been shown. In patients with primary macroglobulinemia, fludarabine improved both progression-free survival and OS as compared with chlorambucil. As to extra-nodal marginal-zone B cell lymphoma, the addition of rituximab to chlorambucil improves both the response rate and event-free survival. Large clinical trials of lenalidomide, idelalisib, and ibrutinib are now ongoing. PMID:26458443

  7. Recent progress in injectable bone repair materials research

    NASA Astrophysics Data System (ADS)

    Chen, Zonggang; Zhang, Xiuli; Kang, Lingzhi; Xu, Fei; Wang, Zhaoling; Cui, Fu-Zhai; Guo, Zhongwu

    2015-12-01

    Minimally invasive injectable self-setting materials are useful for bone repairs and for bone tissue regeneration in situ. Due to the potential advantages of these materials, such as causing minimal tissue injury, nearly no influence on blood supply, easy operation and negligible postoperative pain, they have shown great promises and successes in clinical applications. It has been proposed that an ideal injectable bone repair material should have features similar to that of natural bones, in terms of both the microstructure and the composition, so that it not only provides adequate stimulus to facilitate cell adhesion, proliferation and differentiation but also offers a satisfactory biological environment for new bone to grow at the implantation site. This article reviews the properties and applications of injectable bone repair materials, including those that are based on natural and synthetic polymers, calcium phosphate, calcium phosphate/polymer composites and calcium sulfate, to orthopedics and bone tissue repairs, as well as the progress made in biomimetic fabrication of injectable bone repair materials.

  8. Center for Research for Mothers and Children: 1983 Progress Report.

    ERIC Educational Resources Information Center

    National Inst. of Child Health and Human Development (NIH), Bethesda, MD.

    Described in this report are the extramural activities for fiscal year 1983 of the Center for Research for Mothers and Children (CRMC). The CRMC is designed to advance knowledge about fetal development, pregnancy, and birth; to identify the prerequisites of optimal growth and development through infancy, childhood, and adolescence; and to…

  9. Research program in elementary particle theory, 1980. Progress report

    SciTech Connect

    Sudarshan, E. C.G.; Ne'eman, Y.

    1980-01-01

    Research is reported for these subject areas: particle physics in relativistic astrophysics and cosmology; phenomenology of weak and electromagnetic interactions; strong interaction physics, QCD, and quark-parton physics; quantum field theory, quantum mechanics and fundamental problems; groups, gauges, and grand unified theories; and supergeometry, superalgebra, and unification. (GHT)

  10. Black Faculty at Research Universities: Has Significant Progress Occurred?

    ERIC Educational Resources Information Center

    Modica, Jonathon L.; Mamiseishvili, Ketevan

    2010-01-01

    Changes in the representation, career advancement, and workplace perceptions of Black faculty at research universities in the United States over time, in comparison to White faculty were examined. Based on the analysis of data from the 1993, 1999, and 2004 National Study of Postsecondary Faculty (NSOPF) surveys, we found that although the overall…

  11. Progress in grain pearl millet research and market developments

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pearl millet (Pennisetum glaucum [L.] R. Br.) has historically been grown only for forage and hay in the southern United States. However, recent research and technology transfer activities are resulting in continued improvements in grain hybrids adapted to the southeast and the emergence of new mark...

  12. Materials research and beam line operation utilizing NSLS. Progress report

    SciTech Connect

    Liedl, G.L.

    1993-06-01

    MATRIX, a participating research team of Midwest x-ray scattering specialists, continues to operate beam line X-18A at NSLS. Operations of this line now provides state-of-the-art capabilities to a wide range of people in the Materials Science and Engineering research community. Improvements of the beam line continue to be a focus of MATRIX. Throughout this past year the emphasis has been shifting towards improvement in ``user friendly`` aspects. Simplified control operations and a shift to single-user personal computer has been a major part of the effort. Over the past year all 232 operational days were fully utilized. Beam line tests coupled with MATRIX members combined to use 284 days. General user demand for use of the beam line continues to be strong and four groups were provided 48 operating days. Research production has been growing as NSLS and the beam line become a more stable type of operation. For 1992 the MATRIX group published six articles. To date, for 1993 the same group has published, submitted, or has in preparation nine articles. Recent research milestones include: the first quantitative structural information on the as-quenched and early stages of decomposition of supersaturated Al-Li alloys; the first quantitative diffuse scattering measurements on a complex system (Co substitute for Cu YBCO superconductor); demonstration of capabilities of a new UHV surface diffraction chamber with in-situ characterization and temperature control (30-1300K); feasibility of phasing structure factors in a quasicrystal using multiple Bragg scattering.

  13. Soil & Tillage Research: Publication history and assessment of progress

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The journal, Soil and Tillage Research, is concerned with the changes in physical, chemical and biological properties and processes of the soil environment brought about by soil tillage and field traffic, their effects on both below- and above-ground environmental quality, crop establishment, root d...

  14. Child Development Research Unit Progress Report, February, 1970.

    ERIC Educational Resources Information Center

    University Coll., Nairobi (Kenya).

    To insure the most accurate research, it is necessary to have teams of scientists from the culture being studied and from a contrasting culture. The indigenous members of the team provide a sensitivity to nuances of meaning and interpretations of intent of behavior that cannot easily be recognized by an outsider. The outsider team members will…

  15. [Advanced Gas Turbine Systems Research]. Technical Quarterly Progress Report

    SciTech Connect

    1998-09-30

    Major Accomplishments by Advanced Gas Turbine Systems Research (AGTSR) during this reporting period are highlighted below and amplified in later sections of this report: AGTSR distributed 50 proposals from the 98RFP to the IRB for review, evaluation and rank-ordering during the summer; AGTSR conducted a detailed program review at DOE-FETC on July 24; AGTSR organized the 1998 IRB proposal review meeting at SCIES on September 15-16; AGTSR consolidated all the IRB proposal scores and rank-orderings to facilitate the 98RFP proposal deliberations; AGTSR submitted meeting minutes and proposal short-list recommendation to the IRB and DOE for the 98RFP solicitation; AGTSR reviewed two gas turbine related proposals as part of the CU RFP State Project for renovating the central energy facility; AGTSR reviewed and cleared research papers with the IRB from the University of Pittsburgh, Wisconsin, and Minnesota; AGTSR assisted GTA in obtaining university stakeholder support of the ATS program from California, Pennsylvania, and Colorado; AGTSR assisted GTA in distributing alert notices on potential ATS budget cuts to over 150 AGTSR performing university members; AGTSR submitted proceedings booklet and organizational information pertaining to the OAI hybrid gas turbine workshop to DOE-FETC; For DOE-FETC, AGTSR updated the university consortium poster to include new members and research highlights; For DOE-FETC, the general AGTSR Fact Sheet was updated to include new awards, workshops, educational activity and select accomplishments from the research projects; For DOE-FETC, AGTSR prepared three fact sheets highlighting university research supported in combustion, aero-heat transfer, and materials; For DOE-FETC, AGTSR submitted pictures on materials research for inclusion in the ATS technology brochure; For DOE-FETC, AGTSR submitted a post-2000 roadmap showing potential technology paths AGTSR could pursue in the next decade; AGTSR distributed the ninth newsletter UPDATE to DOE, the

  16. [Research progress of probe design software of oligonucleotide microarrays].

    PubMed

    Chen, Xi; Wu, Zaoquan; Liu, Zhengchun

    2014-02-01

    DNA microarray has become an essential medical genetic diagnostic tool for its high-throughput, miniaturization and automation. The design and selection of oligonucleotide probes are critical for preparing gene chips with high quality. Several sets of probe design software have been developed and are available to perform this work now. Every set of the software aims to different target sequences and shows different advantages and limitations. In this article, the research and development of these sets of software are reviewed in line with three main criteria, including specificity, sensitivity and melting temperature (Tm). In addition, based on the experimental results from literatures, these sets of software are classified according to their applications. This review will be helpful for users to choose an appropriate probe-design software. It will also reduce the costs of microarrays, improve the application efficiency of microarrays, and promote both the research and development (R&D) and commercialization of high-performance probe design software. PMID:24804514

  17. Progress on the pharmacological research of puerarin: a review.

    PubMed

    Wei, Shu-Yong; Chen, Yi; Xu, Xiao-Yu

    2014-06-01

    Contemporary pharmacological research has demonstrated that puerarin, the most important phytoestrogen extracted from Pueraria lobata(Willd.) Ohwi, has protecting functions on the cardiovascular system, nervous system, osteoporosis, liver injury, and inflammation in vivo and in vitro. Most of these research studies focused on inhibiting oxidative stress and apoptosis through regulating various bioactivators and signal pathways. Among these, superoxide dismutase (SOD), endothelial nitric oxide synthase (eNOS) and malondialdehyde (MDA), and PI3K/Akt, MAPK, and NF-κB are of great importance. The data cited in this review were mainly obtained from articles listed in PubMed and Elsevier SDOL published from 1959 to 2013, and the search term used was "puerarin". PMID:24969520

  18. [Research progress on wetland ecosystem service and its valuation].

    PubMed

    Fu, Jiao-Yan; Ding, Zhen-Hua

    2007-03-01

    With the recognition on the significance of wetland, wetland ecosystem service was come under more and more attention, and its valuation could give the policymakers a scientific support in punishing wetland destroyers and compensating its losers. This paper introduced the definitions of wetland ecosystem service, its function and value, summarized their valuation approaches, including market value approach, production function method, opportunity cost approach, shadow project approach, productivity variety approach, human capital approach, travel cost approach, hedonic value approach, contingent value approach and ecological value approach, and discussed the factors affecting the valuation results of these approaches as well as the existing problems in related researches. The further research directions in these fields were also prospected. PMID:17552213

  19. [Research progress on index system of regional ecological risk assessment].

    PubMed

    Meng, Ji-Jun; Zhao, Chun-Hong

    2009-04-01

    Regional ecological risk assessment (RERA) covers the assessments of multiple risk sources, receptors, and endpoints, while the selection of assessment indices is quite complicated, being a hotspot in regional environment management research. Domestic and international researches on RERA revealed that three processes in RERA are of vital, i.e., risk probability assessment measured by risk probability index, status and value assessment of ecosystem at regional scale indicated by ecological index, and vulnerability assessment of each ecosystem in a region under risk measured by vulnerability index. The main problems in the establishment of RERA index system are the strong subjectivity and poor comparability, and thus, the index system should be set up in the three key processes under the principles of objectivity, integration, hierarchy, and comparability. Due to the fact that the status and value assessment of ecosystem is most complicated, the index system should be formulated by compulsory and optional components to increase the comparability of RERA results between regions. PMID:19565785

  20. [Research progress of trans-cinnamaldehyde pharmacological effects].

    PubMed

    Zhang, Li-qing; Zhang, Zhan-gang; Fu, Yan; Xu, Ying

    2015-12-01

    Trans-cinnamaldehyde, the main component of volatile oil from cassia twig or Cinnamomum cassia, which is a traditional Chinese herbal medicine. Trans-cinnamaldehyde is a kind olefine aldehyde of organic compounds and has many pharmacological properties, such as anti-inflammatory, anti-tumor, anti-bacterial, antidiabetic, anti-obesity, and neuroprotection etc. The compound has preventive and therapeutic effects on the nervous system, cardiovascular, cancer, diabetes and other diseases. Trans-cinnamaldehyde, as a preventive care of nature medicine, has great clinical and market potential. This paper gives a review about the pharmacological effects and mechanism of trans-cinnamaldehyde researched in the latest five years. We hope to provide some basic information for further research on trans-cinnamaldehyde. PMID:27141665

  1. [Research progress of quantitative analysis for respiratory sinus arrhythmia].

    PubMed

    Sun, Congcong; Zhang, Zhengbo; Wang, Buqing; Liu, Hongyun; Ang, Qing; Wang, Weidong

    2011-12-01

    Respiratory sinus arrhythmia (RSA) is known as fluctuations of heart rate associated with breathing. It has been increasingly used as a noninvasive index of cardiac vagal tone in psychophysiological research recently. Its analysis is often influenced or distorted by respiratory parameters, posture and action, etc. This paper reviews five methods of quantification, including the root mean square of successive differences (RMSSD), peak valley RSA (pvRSA), cosinor fitting, spectral analysis, and joint timing-frequency analysis (JTFA). Paced breathing, analysis of covariance, residua method and msRSA per liter tidal volume are adjustment strategies of measurement and analysis of RSA in this article as well. At last, some prospects of solutions of the problems of RSA research are given. PMID:22295719

  2. [Research hotspot and progress of preoperative chemoradiotherapy for rectal cancer].

    PubMed

    Peng, Jianhong; Pan, Zhizhong

    2016-06-01

    Preoperative chemoradiotherapy (CRT) has become an important component of comprehensive treatment for rectal cancer. Although local recurrent risk has been remarkably reduced by CRT, distant metastasis remains the main cause of therapeutic failure. Therefore, more and more studies focused on controlling distant metastasis in order to prolong long-term survival. Recently, CRT has achieved certain progression in rectal cancer: (1)Patients with stage T3 should be classified into specific subgroups to formulate individualized treatment regimen. For stage T3a, it is feasible to perform surgery alone or administrate low intensity preoperative CRT; for stage T3b and T3c, conventional preoperative CRT should be performed in order to reduce the risk of recurrence postoperatively. (2)With regard to combined regimen for chemotherapy, oral capecitabine superiors to intravenous bolus 5-fluorouracil (5-FU) and is comparable to continuous intravenous infusion 5-FU with a better safety. Therefore, capecitabine is recommended for older patients and those with poor tolerance to chemotherapy. Compared to single 5-FU concurrent CRT, addition of oxaliplatin into preoperative CRT may result in a higher survival benefit in Chinese patients. As to the application of irinotecan, bevacizumab or cetuximab, unless there are more evidence to confirm their efficacy and safety from randomized controlled trial, they should not be recommended for adding to preoperative CRT routinely. (3)On the optimization in CRT pattern, the application values of induction chemotherapy before concurrent CRT, consolidation chemotherapy after concurrent CRT, neoadjuvant sandwich CRT, neoadjuvant chemotherapy alone and short-course preoperative radiotherapy remain further exploration. (4)On the treatment strategy for clinical complete response (cCR) after CRT, whether "wait and see" strategy is able to be adopted, it is still a hot topic with controversy. PMID:27353093

  3. [The research progress of succinic acid fermentation strains].

    PubMed

    Wang, Qing-Zhao; Zhao, Xue-Ming

    2007-07-01

    The potential of succinic acid as an important chemical intermediates had been realized and fermentation is one of the best ways to make it possible in economical aspect. Fermentation organism is the key part of the fermentation method. The updated research developments of fermentation organisms and the fermentation characteristics and problems of them were reviewed and analyzed in this paper. Finally,the development future of fermenation organism was forecasted. PMID:17822024

  4. [Research progress on application of gold magnetic nanocomposite in biomedicine].

    PubMed

    Xue, Yang; Zhao, Lingyun; Tang, Jingtian; Yao, Cuiping

    2014-04-01

    This paper provides a brief overview of the current research activities which focused on the bio-application of gold magnetic nanocomposite particles. By combining the magnetic characteristics of the iron oxide core with the unique features of nano-gold particles such as targeting by surface modification and optical properties, such composite nanoparticles have a wide range of applications in cancer hyperthermia, CT and MRI imaging, bio-separation, bio sensors, gene diagnosis, drug targeting and many other biomedical fields. PMID:25039160

  5. Progress in thermal comfort research over the last twenty years.

    PubMed

    de Dear, R J; Akimoto, T; Arens, E A; Brager, G; Candido, C; Cheong, K W D; Li, B; Nishihara, N; Sekhar, S C; Tanabe, S; Toftum, J; Zhang, H; Zhu, Y

    2013-12-01

    Climate change and the urgency of decarbonizing the built environment are driving technological innovation in the way we deliver thermal comfort to occupants. These changes, in turn, seem to be setting the directions for contemporary thermal comfort research. This article presents a literature review of major changes, developments, and trends in the field of thermal comfort research over the last 20 years. One of the main paradigm shift was the fundamental conceptual reorientation that has taken place in thermal comfort thinking over the last 20 years; a shift away from the physically based determinism of Fanger's comfort model toward the mainstream and acceptance of the adaptive comfort model. Another noticeable shift has been from the undesirable toward the desirable qualities of air movement. Additionally, sophisticated models covering the physics and physiology of the human body were developed, driven by the continuous challenge to model thermal comfort at the same anatomical resolution and to combine these localized signals into a coherent, global thermal perception. Finally, the demand for ever increasing building energy efficiency is pushing technological innovation in the way we deliver comfortable indoor environments. These trends, in turn, continue setting the directions for contemporary thermal comfort research for the next decades. PMID:23590514

  6. Materials research and beam line operation utilizing NSLS. Progress report

    SciTech Connect

    Liedl, G.L.

    1991-10-01

    MATRIX, a participating research team of Midwest x-ray scattering specialists, continues to operate beam line X-18A at NSLS. Operations of this line now provides state-of-the-art capabilities to a wide range of people in the Materials Science and Engineering research community. Improvements of the beam line continue to be a focus of MATRIX. Throughout this past year the emphasis has been shifting towards improvement in ``user friendly`` aspects. Simplified control operations and a shift to single-user personal computer has been a major part of the effort. Over the past year the full 242 operational days were utilized. Beam line test and evaluation consumed 21 days with eight MATRIX groups combining to use 170 days. General user demand for use of the beam line continues to be strong and three groups were provided 51 operating days. Research production has been growing as NSLS and the beam line become a more stable type of operation. For 1990 the MATRIX group published nine articles. To data for 1991 the same group has published, submitted, or has in preparation twelve articles. Among the milestones achieved last year on MATRIX member obtained the first data from a new ultra high vacuum chamber with low temperature capability. This is a unique capability at NSLS. Another member demonstrated grazing incidence small angle x-ray scattering capability for kinetic studies of film growth.

  7. Safety research programs sponsored by Office of Nuclear Regulatory Research: Progress report, July 1--September 30, 1988

    SciTech Connect

    Weiss, A J

    1989-02-01

    This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through June 30, 1988. 71 figs., 24 tabs.

  8. Progress of Interoperability in Planetary Research for Geospatial Data Analysis

    NASA Astrophysics Data System (ADS)

    Hare, T. M.; Gaddis, L. R.

    2015-12-01

    For nearly a decade there has been a push in the planetary science community to support interoperable methods of accessing and working with geospatial data. Common geospatial data products for planetary research include image mosaics, digital elevation or terrain models, geologic maps, geographic location databases (i.e., craters, volcanoes) or any data that can be tied to the surface of a planetary body (including moons, comets or asteroids). Several U.S. and international cartographic research institutions have converged on mapping standards that embrace standardized image formats that retain geographic information (e.g., GeoTiff, GeoJpeg2000), digital geologic mapping conventions, planetary extensions for symbols that comply with U.S. Federal Geographic Data Committee cartographic and geospatial metadata standards, and notably on-line mapping services as defined by the Open Geospatial Consortium (OGC). The latter includes defined standards such as the OGC Web Mapping Services (simple image maps), Web Feature Services (feature streaming), Web Coverage Services (rich scientific data streaming), and Catalog Services for the Web (data searching and discoverability). While these standards were developed for application to Earth-based data, they have been modified to support the planetary domain. The motivation to support common, interoperable data format and delivery standards is not only to improve access for higher-level products but also to address the increasingly distributed nature of the rapidly growing volumes of data. The strength of using an OGC approach is that it provides consistent access to data that are distributed across many facilities. While data-steaming standards are well-supported by both the more sophisticated tools used in Geographic Information System (GIS) and remote sensing industries, they are also supported by many light-weight browsers which facilitates large and small focused science applications and public use. Here we provide an

  9. Progressive Research and Outreach at the WestRock Observatory

    NASA Astrophysics Data System (ADS)

    Brown, Johnny Eugene; Lantz Caughey, Austin; O'Keeffe, Brendon; Johnson, Michael; Murphy Williams, Rosa Nina

    2016-01-01

    The WestRock Observatory (WRO), located in Columbus State University's Coca-Cola Space Science Center (CCSSC), is dedicated to education and research in astronomy through hands-on engagement and public participation. The WRO has recently received funding to upgrade the PlaneWave CDK 24-inch Corrected Dall-Kirkham Astrograph telescope. Recent additions to the telescope include an all-new Apogee Alta F16 CCD camera complete with a filter wheel (with narrowband and broadband filters) and a Minor Planet Center Observatory Code (W22). These new upgrades have allowed Astrophysics students to conduct unique research ranging from high precision minor planet astrometry, to broad- and narrow-band imaging of nebulae, to light curve analysis for variable star photometry. These new endeavours, in conjunction with an existing suite of Solar telescopes, gives the WRO the ability to live-stream solar and night-time observing. These streams are available both online and through interactive displays at the CCSSC making the WRO an educational outreach program for a worldwide public audience and a growing astronomical community.Current funding is allowing students to get even more research experience than previously attainable further enabling the expansion of our publicly available gallery of nebula and galaxy images. Support and funding for the acquirement,installation, and upgrading of the new PlaneWave CDK24 has been provided by the International Museum and Library Services via the Museums for America Award Additionally, individual NASA Space Grant Scholarships have helped to secure a number of student interns partially responsible for recent improvements.

  10. [Research progress on phosphorus budgets and regulations in reservoirs].

    PubMed

    Shen, Xiao; Li, Xu; Zhang, Wang-shou

    2014-12-01

    Phosphorus is an important limiting factor of water eutrophication. A clear understanding of its budget and regulated method is fundamental for reservoir ecological health. In order to pro- mote systematic research further and improve phosphorus regulation system, the budget balance of reservoir phosphorus and its influencing factors were concluded, as well as conventional regulation and control measures. In general, the main phosphorus sources of reservoirs include upstream input, overland runoff, industrial and domestic wastewater, aquaculture, atmospheric deposition and sediment release. Upstream input is the largest phosphorus source among them. The principal output path of phosphorus is the flood discharge, the emission load of which is mainly influenced by drainage patterns. In addition, biological harvest also can export a fraction of phosphorus. There are some factors affecting the reservoir phosphorus balance, including reservoirs' function, hydrological conditions, physical and chemical properties of water, etc. Therefore, the phosphorus budgets of different reservoirs vary greatly, according to different seasons and regions. In order to reduce the phosphorus loading in reservoirs, some methods are carried out, including constructed wetlands, prefix reservoir, sediment dredging, biomanipulation, etc. Different methods need to be chosen and combined according to different reservoirs' characteristics and water quality management goals. Thus, in the future research, it is reasonable to highlight reservoir ecological characteristics and proceed to a complete and systematic analysis of the inherent complexity of phosphorus budget and its impact factors for the reservoirs' management. Besides, the interaction between phosphorus budget and other nutrients in reservoirs also needs to be conducted. It is fundamental to reduce the reservoirs' phosphorus loading to establish a scientific and improved management system based on those researches. PMID:25876422

  11. Recent progress in InP solar cell research

    NASA Technical Reports Server (NTRS)

    Weinberg, Irving; Brinker, D. J.; Jain, R. K.; Swartz, C. K.

    1991-01-01

    Significant new developments in InP solar cell research are reviewed. Recent accomplishments include monolithic multibandgap two junction cells (three and two terminal) using InP as the top cell and lattice matched GaInAs and GaInAsP as the bottom, low bandgap component. Concentrator cells include the three terminal multibandgap cell and n + p cell using an InP substrate. The review also includes small scale production of ITO/InP cells and results for n + p InP and ITO/InP cells in space on board the LIPS 3 satellite.

  12. [Research Progress in Black Queen Cell Virus Causing Disease].

    PubMed

    Yang, Qian; Zhang, Jian; Song, Zhanyun; Zheng, Yan; Wang, Xianghui; Sui, Jiachen; Wang, Zhenguo; Mou, Jun

    2015-05-01

    In nature, honeybees are the most important pollinators. They play a vital role in both protecting the diversity of natural ecosystems, and maintaining the yield-improving effects of agroecosystems. But in recent years, epidemic disease in bees has caused huge losses. Black Queen Cell Virus (BQCV) is a bee pathogen that was first reported in 1955. It mainly infects bee larvae and pupae, making their bodies turn dark and black, and causing a massive decrease in the bee population. More specifically, the virus makes the exterior of the cell walls in the larvae and pupae turn black. BQCV is a seasonal epidemic, spread by means horizontal and vertical transmission, and is often unapparent. BQCV not only infects a variety of bee species, but also spiders, centipedes and other arthropods. It can also be coinfected with other honeybee viruses. In recent years, research has shown that the Nosema intestinal parasite plays an important role in BQCV transmission and bees carrying Nosema that become infected with BQCV have increased mortality. Here we summarize current research on the incidence, prevalence, geographical distribution and transmission of BQCV. PMID:26470541

  13. Research Progress Concerning Fungal and Bacterial β-Xylosidases.

    PubMed

    Bosetto, Adilson; Justo, Priscila Innocenti; Zanardi, Bruna; Venzon, Simoni Spohr; Graciano, Luciana; dos Santos, Elaine Luzia; Simão, Rita de Cássia Garcia

    2016-02-01

    In the present review, we briefly summarize the biotechnological applications of microbial β-xylosidases in the processing of agro-industrial residues into fuels and chemicals and report the importance of using immobilization techniques to study the enzyme. The advantages of utilizing genes that encode β-xylosidases are readily apparent in the bioconversion of abundant, inexpensive, and renewable resources into economically important products, such as xylitol and bioethanol. We highlight recent research characterizing fungal and bacterial β-xylosidases, including the use of classical biochemical methods such as purification, heterologous recombinant protein expression, and metagenomic approaches to discovery β-xylosidases, with focus on enzyme molecular and kinetic properties. In addition, we discuss the relevance of using experimental design optimization methodologies to increase the efficacy of these enzymes for use with residual biomass. Finally, we emphasize more extensively the advances in the regulatory mechanisms governing β-xylosidase gene expression and xylose metabolism in gram-negative and gram-positive bacteria and fungi. Unlike previous reviews, this revision covers recent research concerning the various features of bacterial and fungal β-xylosidases with a greater emphasis on their biochemical characteristics and how the genes that encode these enzymes can be better exploited to obtain products of biotechnological interest via the application of different technical approaches. PMID:26536888

  14. Nuclear research with the electromagnetic probe. Final progress report

    SciTech Connect

    Meziani, Z.E.

    1994-10-01

    This is the final report on the research carried at Stanford University under contract DE-FG03-88ER40439. All the work accomplished under this grant is reported in the publications listed as part of the Principal Investigator bibliography at the end of this report. In the last few years our research was directed at some of the forefront questions in nuclear physics. We investigated the nuclear medium effects on the intrinsic properties of bound nucleons, specifically the ectromagnetic form factors. For these studies we performed a number of specialized electron scattering experiments with specific sensitivity to nuclear medium effects. At the next level of structure, elementary constituents of matter are quarks and gluons. Defining the energy regime where the quark-gluon description of nuclear systems becomes more relevant than the nucleon-meson description is of great importance in thoroughly understanding the nuclear structure. To explore this transition region, we studied the scaling region in the disintegration of the deuteron, the simplest nuclear system with high energy photons. Finally we focused on the investigation of the nucleon internal spin structure along with the test of the Bjoerken sum rule a fundamental sum rule of QCD.

  15. Cylindrospermopsin: A Decade of Progress on Bioaccumulation Research

    PubMed Central

    Kinnear, Susan

    2010-01-01

    Cylindrospermopsin (CYN) is rapidly being recognised as one of the most globally important of the freshwater algal toxins. The ever-expanding distribution of CYN producers into temperate zones is heightening concern that this toxin will represent serious human, as well as environmental, health risks across many countries. Since 1999, a number of studies have demonstrated the ability for CYN to bioaccumulate in freshwater organisms. This paper synthesizes the most current information on CYN accumulation, including notes on the global distribution of CYN producers, and a précis of CYN’s ecological and human effects. Studies on the bioaccumulation of CYN are systematically reviewed, together with an analysis of patterns of accumulation. A discussion on the factors influencing bioaccumulation rates and potential is also provided, along with notes on detection, monitoring and risk assessments. Finally, key gaps in the existing research are identified for future study. PMID:20411114

  16. Progress in the research and development of photonic structure devices

    NASA Astrophysics Data System (ADS)

    Pham, Van Hoi; Bui, Huy; Van Nguyen, Thuy; Nguyen, The Anh; Son Pham, Thanh; Pham, Van Dai; Cham Tran, Thi; Trang Hoang, Thu; Ngo, Quang Minh

    2016-03-01

    In this paper we review the results of the research and development of photonic structure devices performed in the Institute of Materials Science in the period from 2010-2015. We have developed a configuration of 1D photonic crystal (PC) microcavities based on porous silicon (PS) layers and applied them to optical sensing devices that can be used for the determination of organic content with a very low concentration in different liquid environments. Various important scientific and technological applications of photonic devices such as the ultralow power operation of microcavity lasers, the inhibition of spontaneous emissions and the manipulation of light amplification by combining the surface plasmonic effect and the microcavity are expected. We developed new kinds of photonic structures for optical filters based on guided-mode resonances in coupled slab waveguide gratings, which have great potential for application in fiber-optic communication and optical sensors.

  17. Research in nuclear chemistry. Progress report. [Bio Rex-70

    SciTech Connect

    Choppin, Gregory R.

    1980-01-01

    The research is concerned primarily with complexes in aqueous solution of actinide elements. Actinides in the trivalent oxidation state have been studied more than species in other valence states. Similar systems have also been investigated for the trivalent lanthanides. Since 15 lanthanides can be studied using a wider variety of techniques than feasible with the actinides (e.g., NMR), comparison of these closely related families of elements using the greater amount and variety of lanthanide data provides better understanding of actinide behavior. The studies have included measurements of the thermodynamic parameters of complexation for both inorganic and organic ligands, of the kinetics of complexation, of the spectroscopic properties of complex species using f reverse arrow f electronic transitions, of the nuclear magnetic resonance spectroscopy of the complexed ligands and of binding to natural polyelectrolytes such as humic acid.

  18. Progress in Technology Research and Development for NCSX

    NASA Astrophysics Data System (ADS)

    Neilson, G.; Chrzanowski, J.; Heitzenroeder, P.; Raftopoulos, S.; Reiersen, W.; Viola, M.; Goranson, P.; Lyon, J.; Nelson, B.; Williamson, D.

    2003-10-01

    The physics mission of the National Compact Stellarator Experiment imposes demanding requirements on the manufacturing technologies for the modular coils and vacuum vessel. These components must satisfy complex three-dimensional shape specifications to high accuracy while meeting their performance requirements. A research and development program is being carried out by PPPL, ORNL, and industry to demonstrate the necessary technologies. Advanced numerical modeling, metrology, and manufacturing methods are being developed to optimize the fabrication of the modular coil winding forms (by casting and machining) and vacuum vessel (by forming and welding). Coil winding developments include flexible cable design, epoxy impregnation of complex-shaped windings, metrology, composite materials properties, and dimensional control during the winding process.

  19. [Research progress on current pharmacokinetic evaluation of Chinese herbal medicines].

    PubMed

    Li, Guofu; Zhao, Haoru; Yang, Jin

    2011-03-01

    In order to prove safety and efficacy, herbal medicines must undergo the rigorous scientific researches such as pharmacokinetic and bioavailability, before they are put on the market in the foreign countries. Botanical Drug Products promulgated by the US FDA could guide industry sponsors to develop herbal drugs, which was also an important reference for investigating Chinese herbal medicines. This paper reviews and discusses novel approaches for how to assess systemic exposure and pharmacokinetic of Chinese herbal medicines, which were in line with FDA guidance. This mainly focus on identifying pharmacokinetic markers of botanical products, integral pharmacokinetic study of multiple components, Biopharmaceutics drug disposition classification system, and population pharmacokinetic-pharmacodynamic study in herb-drug interaction. PMID:21657088

  20. [Research progress in microbial methane oxidation coupled to denitrification].

    PubMed

    Zhu, Jing; Yuan, Meng-Dong; Liu, Jing-Jing; Huang, Xiao-Xiao; Wu, Wei-Xiang

    2013-12-01

    Methane oxidation coupled to denitrification is an essential bond to connect carbon- and nitrogen cycling. To deeply research this process will improve our understanding on the biochemical cycling of global carbon and nitrogen. As an exogenous gaseous carbon source of denitrification, methane can both regulate the balance of atmospheric methane to effectively mitigate the greenhouse effect caused by methane, and reduce the cost of exogenous carbon source input in traditional wastewater denitrification treatment process. As a result, great attention has being paid to the mechanical study of the process. This paper mainly discussed the two types of methane oxidation coupled to denitrification, i. e., aerobic methane oxidation coupled to denitrification (AME-D) and anaerobic methane oxidation coupled to denitrification (ANME-D), with the focus on the microbiological coupling mechanisms and related affecting factors. The existing problems in the engineering application of methane oxidation coupled to denitrification were pointed out, and the application prospects were approached. PMID:24697087

  1. [Research in elementary particles and interactions]. Technical progress report

    SciTech Connect

    Adair, R.; Sandweiss, J.; Schmidt, M.

    1992-05-01

    Research of the Yale University groups in the areas of elementary particles and their interactions are outlined. Work on the following topics is reported: development of CDF trigger system; SSC detector development; study of heavy flavors at TPL; search for composite objects produced in relativistic heavy-ion collisions; high-energy polarized lepton-nucleon scattering; rare K{sup +} decays; unpolarized high-energy muon scattering; muon anomalous magnetic moment; theoretical high-energy physics including gauge theories, symmetry breaking, string theory, and gravitation theory; study of e{sup +}e{sup {minus}} interactions with the SLD detector at SLAC; and the production and decay of particles containing charm and beauty quarks.

  2. Nitrilases in nitrile biocatalysis: recent progress and forthcoming research

    PubMed Central

    2012-01-01

    Over the past decades, nitrilases have drawn considerable attention because of their application in nitrile degradation as prominent biocatalysts. Nitrilases are derived from bacteria, filamentous fungi, yeasts, and plants. In-depth investigations on their natural sources function mechanisms, enzyme structure, screening pathways, and biocatalytic properties have been conducted. Moreover, the immobilization, purification, gene cloning and modifications of nitrilase have been dwelt upon. Some nitrilases are used commercially as biofactories for carboxylic acids production, waste treatment, and surface modification. This critical review summarizes the current status of nitrilase research, and discusses a number of challenges and significant attempts in its further development. Nitrilase is a significant and promising biocatalyst for catalytic applications. PMID:23106943

  3. Progress in Open Rotor Research: A U.S. Perspective

    NASA Technical Reports Server (NTRS)

    Van Zante, Dale E.

    2015-01-01

    In response to the 1970s oil crisis, NASA created the Advanced Turboprop Project (ATP) to mature technologies for high-speed propellers to enable large reductions in fuel burn relative to turbofan engines of that era. Both single rotation and contra-rotation concepts were designed and tested in ground based facilities as well as flight. Some novel concepts configurations that were not well publicized at the time, were proposed as part of the effort. The high-speed propeller concepts did provide fuel burn savings, albeit with some acoustics and structural challenges to overcome. When fuel prices fell, the business case for radical new engine configurations collapsed and the research emphasis returned to high bypass ducted configurations. With rising oil prices and increased environmental concerns there is renewed interest in high-speed propeller based engine architectures. Contemporary analysis tools for aerodynamics and aeroacoustics have enabled a new era of blade designs that have both high efficiency and acceptable noise characteristics. A recent series of tests in the U.S. have characterized the aerodynamic performance and noise from these modern contra-rotating propeller designs. Additionally the installation and noise shielding aspects for conventional airframes and blended wing bodies have been studied. Historical estimates of propfan performance have relied on legacy propeller performance and acoustics data. Current system studies make use of the modern propeller data with higher fidelity installation effects data to estimate the performance of a contemporary aircraft system with favorable results. This paper presents the current state of high-speed propeller open rotor research within the U.S. from an overall viewpoint of the various efforts ongoing. The current projections for the technology are presented.

  4. Progress in Open Rotor Research: A U.S. Perspective

    NASA Technical Reports Server (NTRS)

    Van Zante, Dale E.

    2015-01-01

    In response to the 1970s oil crisis, NASA created the Advanced Turboprop Project (ATP) to mature technologies for high-speed propellers to enable large reductions in fuel burn relative to turbofan engines of that era. Both single rotation and contra- rotation concepts were designed and tested in ground based facilities as well as flight. Some novel concepts/configurations were proposed as part of the effort. The high-speed propeller concepts did provide fuel burn savings, albeit with some acoustics and structural challenges to overcome. When fuel prices fell, the business case for radical new engine configurations collapsed and the research emphasis returned to high bypass ducted configurations. With rising oil prices and increased environmental concerns there is renewed interest in high-speed propeller based engine architectures. Contemporary analysis tools for aerodynamics and aeroacoustics have enabled a new era of blade designs that have both high efficiency and lower noise characteristics. A recent series of tests in the U.S. have characterized the aerodynamic performance and noise from these modern contra-rotating propeller designs. Additionally the installation and noise shielding aspects for conventional airframes and blended wing bodies have been studied. Historical estimates of 'propfan' performance have relied on legacy propeller performance and acoustics data. Current system studies make use of the modern propeller data and higher fidelity installation effects data to estimate the performance of a contemporary aircraft system. Contemporary designs have demonstrated high net efficiency, approximately 86%, at 0.78 Mach, and low noise, greater than 15 EPNdB cumulative margin to Chapter 4 when analyzed on a NASA derived aircraft/mission. This paper presents the current state of high-speed propeller/open rotor research within the U.S. from an overall viewpoint of the various efforts ongoing. The remaining technical challenges to a production engine include

  5. (Mis)Understanding Human Beings: Theory, Value, and Progress in Education Research

    ERIC Educational Resources Information Center

    Hostetler, Karl

    2010-01-01

    There is renewed interest in what can be called an "experimentist" approach to education research. The claim is that if researchers would focus on experiments and "evidence-based" policies and practices, irreversible progress in education can be achieved. This experimentist approach cannot provide the understanding of knowledge and human beings…

  6. Contracts for field projects and supporting research on enhanced oil recovery. Progress review number 87

    SciTech Connect

    1997-10-01

    Approximately 30 research projects are summarized in this report. Title of the project, contract number, company or university, award amount, principal investigators, objectives, and summary of technical progress are given for each project. Enhanced oil recovery projects include chemical flooding, gas displacement, and thermal recovery. Most of the research projects though are related to geoscience technology and reservoir characterization.

  7. A decade of conservation effects assessment research by USDA-ARS: Progress overview and future outlook

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Ten years ago, the USDA-Agricultural Research Service (ARS) began a series of watershed assessment studies as part of the Conservation Effects Assessment Project (CEAP). In this overview, we review a decade of research progress in 14 watersheds dominated by rain-fed croplands, to introduce a special...

  8. Health and Safety Research Division. Progress report, October 1, 1979-March 31, 1981

    SciTech Connect

    Not Available

    1981-08-01

    Research progress for the period October 1, 1979 through March 31, 1981 is reported. Research conducted by the Office of Integrated Assessments and Policy Analysis, Health Studies Section, Technology Assessments Section, Biological and Radiation Physics Section, and Chemical Physics Section is summarized. (ACR)

  9. Water Reactor Safety Research Division quarterly progress report, January 1-March 31, 1980

    SciTech Connect

    Romano, A.J.

    1980-06-01

    The Water Reactor Safety Research Programs Quarterly Report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the USNRC Division of Reactor Safety Research. The projects reported each quarter are the following: LWR Thermal Hydraulic Development, Advanced Code Evaluation, TRAC Code Assessment, and Stress Corrosion Cracking of PWR Steam Generator Tubing.

  10. Water Reactor Safety Research Division. Quarterly progress report, April 1-June 30, 1980

    SciTech Connect

    Abuaf, N.; Levine, M.M.; Saha, P.; van Rooyen, D.

    1980-08-01

    The Water Reactor Safety Research Programs quarterly report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the USNRC Division of Reactor Safety Research. The projects reported each quarter are the following: LWR Thermal Hydraulic Development, Advanced Code Evlauation, TRAC Code Assessment, and Stress Corrosion Cracking of PWR Steam Generator Tubing.

  11. Research on Spoken Language Processing. Progress Report No. 21 (1996-1997).

    ERIC Educational Resources Information Center

    Pisoni, David B.

    This 21st annual progress report summarizes research activities on speech perception and spoken language processing carried out in the Speech Research Laboratory, Department of Psychology, Indiana University in Bloomington. As with previous reports, the goal is to summarize accomplishments during 1996 and 1997 and make them readily available. Some…

  12. [Research progress on the risk factors of geographic tongue].

    PubMed

    Huamei, Yang; Yu, Zhou; Xin, Zeng; Ga, Liao; Qianming, Chen

    2015-02-01

    Geographic tongue, also called benign migratory glossitis, is a common and superficial benign inflammatory disorder that affects the tongue epithelium. The majority of geographic tongue lesions typically manifest as irregular central erythematous patches. These lesions, which are caused by the loss of filiform papillae, are defined by an elevated whitish band-like border that can change location, size, and pattern over a period of time. Histological observations of the oral mucosa affected by geographic tongue revealed nonspecific inflammation. Some reports described cases of migratory stomatitis, wherein lesions simultaneously manifested on the extra lingual oral mucosa. This condition is also called ectopic geographic tongue, which is clinically and histologically similar to the type normally confined to the tongue. In most cases, patients are asymptomatic and do not require treatment. The condition may spontaneously exhibit periods of remission and exacerbation with good prognosis. The specific etiology of geographic tongue remains unknown. Geographic tongue is age-related and is prevalent among young individuals. Various etiological factors that have been suggested in literature include immunological factors, genetic factors, atopic or allergic tendency, emotional stress, tobacco consumption, hormonal disturbances, and zinc deficiency. Geographic tongue may coexist with other disorders, such as fissured tongue, psoriasis, diabetes mellitus, gastroin- testinal diseases, burning mouth syndrome, and Down syndrome. Experts currently disagree on whether geographic tongue is an oral manifestation of psoriasis. Moreover, some scholars suggest that geographic tongue is a prestage of fissured tongue. The objective of this review is to summarize current research on risk factors of geographic tongue. PMID:25872308

  13. Research progress in the genetics of hyperuricaemia and gout.

    PubMed

    Min, Zheng; Junwu, Ma

    2016-04-01

    Gout is one of the most common inflammatory arthritis caused by hyperuricaemia, which is affected by both genetic factors and environmental factors. Early researches show that a few of rare monogenic mutations, such as PRPS1 and HPRT1 mutations, lead to abnormal purine anabolism and then cause hyperuricaemia and gout. In recent years, genome-wide association studies (GWAS) have identified dozens of susceptibility loci and/or candidate genes associated with hyperuricemia and gout. Loss-of-function mutations in SLC2A9, SLC22A11, and SLC22A12 cause hereditary hypouricaemia, while their overexpression may increase the reabsorption of uric acid. In contrast, loss-of-function mutations in ABCG2, SLC17A1, and SLC17A3 cause urate underexcretion of renal and intestinal. These variations leading to blood uric acid excretion disorder (excess reabsorption and underexcretion) are the main genetic factors affecting hyperuicemia and gout. Moreover, to some degree, inhibins-activins growth factor system, transcription factors, cytoskeleton and gene-environment interaction can also affect the level of blood uric acid. In addition, two risk genes, RFX3 and KCNQ1, which might impair immune response and lead to functional deficiency of beta cell were recently discovered to influence hyperuiceamia and gout in Han Chinese. This paper systematically reviews genetic studies on hyperuricaemia and gout to improve our understanding of pathogenesis of hyperuricaemia and gout. PMID:27103454

  14. Highlights of recent progress in plant lipid research.

    PubMed

    Lessire, R; Cahoon, E; Chapman, K; Dyer, J; Eastmond, P; Heinz, E

    2009-06-01

    Raw fossil material reserves are not inexhaustible and as prices continue to raise it is necessary to find new sources of alternative and renewable energy. Oils from oleaginous field crops (sunflower and rape) with properties close to those of fossil fuel could constitute an alternative source of energy for the production of raw materials. This is the context in which the 18th International Symposium on Plant lipids (ISPL) was held in Bordeaux from 20th to 25th July 2008 at "La Cité Mondiale". The 18th ISPL gathered 270 researchers from 33 countries. Sixty nine oral communications and 136 posters were presented during the 12 sessions of the Symposium. The sessions have covered all the different aspects of the Plant Lipid field including: Surface lipids: suberin, cutin and waxes, Fatty acids, Glycerolipids, Plant lipids as renewable sources of energy, Seed oils and bioengineering of metabolic pathways, Lipid catabolism, Models for lipid studies: lower plants, micro-organisms and others, Modifications of proteins by lipids, Sphingolipids, sterols and isoprenoids, Lipid signaling and plant stress responses, Lipid trafficking and membrane dynamics, New methods and technologies: functional lipidomics, fluxome, modelling. During the ISPL 2008 Bordeaux, important and new information was reported in the different fields. A selection of these results is presented here. PMID:19328004

  15. Current Progress of Genetically Engineered Pig Models for Biomedical Research

    PubMed Central

    Gün, Gökhan

    2014-01-01

    Abstract The first transgenic pigs were generated for agricultural purposes about three decades ago. Since then, the micromanipulation techniques of pig oocytes and embryos expanded from pronuclear injection of foreign DNA to somatic cell nuclear transfer, intracytoplasmic sperm injection-mediated gene transfer, lentiviral transduction, and cytoplasmic injection. Mechanistically, the passive transgenesis approach based on random integration of foreign DNA was developed to active genetic engineering techniques based on the transient activity of ectopic enzymes, such as transposases, recombinases, and programmable nucleases. Whole-genome sequencing and annotation of advanced genome maps of the pig complemented these developments. The full implementation of these tools promises to immensely increase the efficiency and, in parallel, to reduce the costs for the generation of genetically engineered pigs. Today, the major application of genetically engineered pigs is found in the field of biomedical disease modeling. It is anticipated that genetically engineered pigs will increasingly be used in biomedical research, since this model shows several similarities to humans with regard to physiology, metabolism, genome organization, pathology, and aging. PMID:25469311

  16. Research progress of genome editing and derivative technologies in plants.

    PubMed

    Qiwei, Shan; Caixia, Gao

    2015-10-01

    Genome editing technologies using engineered nucleases have been widely used in many model organisms. Genome editing with sequence-specific nuclease (SSN) creates DNA double-strand breaks (DSBs) in the genomic target sites that are primarily repaired by the non-homologous end joining (NHEJ) or homologous recombination (HR) pathways, which can be employed to achieve targeted genome modifications such as gene mutations, insertions, replacements or chromosome rearrangements. There are three major SSNs─zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats/CRISPR-associated 9 (CRISPR/Cas9) system. In contrast to ZFN and TALEN, which require substantial protein engineering to each DNA target, the CRISPR/Cas9 system requires only a change in the guide RNA. For this reason, the CRISPR/Cas9 system is a simple, inexpensive and versatile tool for genome engineering. Furthermore, a modified version of the CRISPR/Cas9 system has been developed to recruit heterologous domains that can regulate endogenous gene expression, such as activation, depression and epigenetic regulation. In this review, we summarize the development and applications of genome editing technologies for basic research and biotechnology, as well as highlight challenges and future directions, with particular emphasis on plants. PMID:26496748

  17. Research progress on the proliferation and differentiation of

    NASA Astrophysics Data System (ADS)

    An, A.; Tan, B.

    Space environments such as microgravity magnetic field radiation and heavy metal ions affects the development and functions of human and mammalian cells To study these influences and the corresponding metabolisms is in favour of knowing about the development and differentiation process of organism cells In recent years researches on the differentiation of stem cells induced in vitro provide a new pathway for the repair of tissue lesion and therapy of human diseases Stem cells are potential in capable of differentiating into different functional cells But there has no reliable methods to induce the stem cells differentiating forward specific cells and to gain enough cells for transplantation which limited their application on clinical therapy It has been indicated that microgravity influenced embryonic development hematopoietic and mesenchymal stem cells and so on Hematopoietic stem cell migration and its differentiation were affected by microgravity The specific differentiation of hematopoietic stem cells was inhibited under microgravity The expression of proteins regulating cell cycle period also changed Mesenchymal stem cells provide a source of cells for the repair of musculoskeletal tissue in ground experiment While under microgravity the proliferation and differentiation of mesenchymal stem cells were influenced along with the differentiated cells function changed Furthermore in the differentiation process of stem cells under microgravity the mechanism of signal transport was also affected and the specific differentiation

  18. AB017. Basic research progress in microenergy medicine

    PubMed Central

    Xin, Zhongcheng

    2016-01-01

    In the last decade, the convergence of life sciences, physical sciences, and engineering has brought a host of opportunities and innovations for biomedical informatics and health care in microenergy medicine, and it is called the third revolution in the field of life science research. Low-energy shock wave therapy (LESWT), a form of physical therapy in energy medicine, was shown to markedly improve erectile function in patients with organic ED, as well as in diabetic rats. In addition, LESWT has been demonstrated to facilitate elongation of myelinated axons, with consequent neurologic functional recovery in a rat model. Low-intensity pulsed ultrasound (LIPUS) is a form of ultrasound that delivered at a much lower intensity than traditional ultrasound energy and output in the mode of pulse wave. LIPUS have been demonstrated to have a rage of biological effects on tissues, including promoting bone-fracture healing, accelerating soft-tissue regeneration, inhibiting inflammatory responses and so on. Recent studies showed that biological effects of LIPUS in healing morbid body tissues may be mainly associated with the upregulation of cell proliferation and promoting multilineage differentiation of mesenchyme stem/progenitor cell lines. Therapeutic magnetic field, a good paradigm of convergence medicine, has been demonstrated to have beneficial results in benign prostatic hyperplasia (BPH), human breast carcinoma, peripheral nerve regeneration, hand osteoarthritis, osteonecrosis, and nucleic acid delivery. Magnetic field has been proven to be a safe, non-invasive method for numerous cell and tissue modifications, especially in musculoskeletal system.

  19. A Tool for Measuring NASA's Aeronautics Research Progress Toward Planned Strategic Community Outcomes

    NASA Technical Reports Server (NTRS)

    Tahmasebi, Farhad; Pearce, Robert

    2016-01-01

    Description of a tool for portfolio analysis of NASA's Aeronautics research progress toward planned community strategic Outcomes is presented. For efficiency and speed, the tool takes advantage of a function developed in Excels Visual Basic for Applications. The strategic planning process for determining the community Outcomes is also briefly discussed. Stakeholder buy-in, partnership performance, progress of supporting Technical Challenges, and enablement forecast are used as the criteria for evaluating progress toward Outcomes. A few illustrative examples of using the tool are also presented.

  20. Observational and research progress of the M51 galaxy

    NASA Astrophysics Data System (ADS)

    Chen, Zhu; Williams, Peter

    2006-12-01

    -wavelength observations and recent research results of M51, discuss the improvements and drawbacks of its simulation results and also summarize the available observations of NGC 5195.

  1. Trauma research in Qatar: a literature review and discussion of progress after establishment of a trauma research centre.

    PubMed

    El-Menyar, A; Asim, M; Zarour, A; Abdelrahman, H; Peralta, R; Parchani, A; Al-Thani, H

    2016-11-01

    A structured research programme is one of the main pillars of a trauma care system. Despite the high rate of injury-related mortalities, especially road traffic accidents, in Qatar, little consideration has been given to research in trauma. This review aimed to analyse research publications on the subject of trauma published from Qatar and to discuss the progress of clinical research in Qatar and the Gulf Cooperation Council countries with special emphasis on trauma research. A literature search using PubMed and Google Scholar search engines located 757 English-language articles within the fields of internal medicine, surgery and trauma originating from Qatar between the years 1993 and 2013. A steep increase in the number of trauma publications since 2010 could be linked to the setting up of a trauma research centre in Qatar in 2011. We believe that establishing a research unit has made a major impact on research productivity, which ultimately benefits health care. PMID:26857718

  2. Annual research progress report, FY 1980. Annual report 1 Oct 79-30 Sep 80

    SciTech Connect

    Marshall, J.D.

    1980-10-01

    During Fiscal Year 1980 progress was attained at the Letterman Army Institute of Research in the following research areas: Basic and applied studies on blood, blood products and blood substitutes; physiology of hemorrhagic shock, pharmacological intervention of shock; the determination of coherent radiation exposure thresholds causing damage to the eye, definition and treatment for laser injuries of the skin and eye; military stress and combat effectiveness; evaluation and toxicology of insect repellents; defense against chemical agents. The progress made in this fiscal year is described in the reports of the work units presented.

  3. Mathematics and statistics research department. Progress report, period ending June 30, 1981

    SciTech Connect

    Lever, W.E.; Kane, V.E.; Scott, D.S.; Shepherd, D.E.

    1981-09-01

    This report is the twenty-fourth in the series of progress reports of the Mathematics and Statistics Research Department of the Computer Sciences Division, Union Carbide Corporation - Nuclear Division (UCC-ND). Part A records research progress in biometrics research, materials science applications, model evaluation, moving boundary problems, multivariate analysis, numerical linear algebra, risk analysis, and complementary areas. Collaboration and consulting with others throughout the UCC-ND complex are recorded in Part B. Included are sections on biology and health sciences, chemistry, energy, engineering, environmental sciences, health and safety research, materials sciences, safeguards, surveys, and uranium resource evaluation. Part C summarizes the various educational activities in which the staff was engaged. Part D lists the presentations of research results, and Part E records the staff's other professional activities during the report period.

  4. US Army Research Office research in progress, July 1, 1991--June 30, 1992

    SciTech Connect

    Not Available

    1992-12-31

    The US Army Research Office, under the US Army Materiel Command (AMC), is responsible for coordinating and supporting research in the physical and engineering sciences, in materials science, geosciences, biology, and mathematics. This report describes research directly supported by the Army Research Projects Agency, and several AMC and other Army commands. A separate section is devoted to the research program at the US Army Research, Development and Standardization Group - United Kingdom. The present volume includes the research program in physics, chemistry, biological sciences, mathematics, engineering sciences, metallurgy and materials science, geosciences, electronics, and the European Research Program. It covers the 12-month period from 1 July 1991 through 30 June 1992.

  5. Mathematics and statistics research progress report, period ending June 30, 1983

    SciTech Connect

    Beauchamp, J. J.; Denson, M. V.; Heath, M. T.; Lever, W. E.; Wilson, D. G.

    1983-08-01

    This report is the twenty-sixth in the series of progress reports of Mathematics and Statistics Research of the Computer Sciences organization, Union Carbide Corporation Nuclear Division. Part A records research progress in analysis of large data sets, applied analysis, biometrics research, computational statistics, materials science applications, numerical linear algebra, and risk analysis. Collaboration and consulting with others throughout the Oak Ridge Department of Energy complex are recorded in Part B. Included are sections on biological sciences, energy, engineering, environmental sciences, health and safety, and safeguards. Part C summarizes the various educational activities in which the staff was engaged. Part D lists the presentations of research results, and Part E records the staff's other professional activities during the report period.

  6. Mathematics and Statistics Research Department progress report, period ending June 30, 1982

    SciTech Connect

    Denson, M.V.; Funderlic, R.E.; Gosslee, D.G.; Lever, W.E.

    1982-08-01

    This report is the twenty-fifth in the series of progress reports of the Mathematics and Statistics Research Department of the Computer Sciences Division, Union Carbide Corporation Nuclear Division (UCC-ND). Part A records research progress in analysis of large data sets, biometrics research, computational statistics, materials science applications, moving boundary problems, numerical linear algebra, and risk analysis. Collaboration and consulting with others throughout the UCC-ND complex are recorded in Part B. Included are sections on biology, chemistry, energy, engineering, environmental sciences, health and safety, materials science, safeguards, surveys, and the waste storage program. Part C summarizes the various educational activities in which the staff was engaged. Part D lists the presentations of research results, and Part E records the staff's other professional activities during the report period.

  7. The Family Development Research Program: A Program for Prenatal, Infant and Early Childhood Enrichment. Progress Report.

    ERIC Educational Resources Information Center

    Lally, J. Ronald

    This progress report on the Family Development Research Program for 108 low-income families, conducted at Syracuse University Children's Center, provides information on a longitudinal comparison instituted when the program children reached 36 months of age. The families of the children were matched to control families on a number of variables.…

  8. Autism Research and Services for Young Children: History, Progress and Challenges

    ERIC Educational Resources Information Center

    Thompson, Travis

    2013-01-01

    For three decades after Leo Kanner's first clinical description, research progress in understanding and treating autism was minimal but since the late 1960s the growth of autism discoveries has been exponential, with a remarkable number of new findings published over the past two decades, in particular. These advances were made possible first by…

  9. Health and Safety Research Division progress report, April 1, 1981-September 30, 1982

    SciTech Connect

    Not Available

    1983-02-01

    Research progress for the reporting period is briefly summarized for the following sections: (1) health studies, (2) technology assessments, (3) biological and radiation physics, (4) chemical physics, (5) Office of Risk Analysis, and (6) health and environmental risk and analysis. (ACR)

  10. Health and Safety Research Division progress report for the period October 1, 1991--March 31, 1993

    SciTech Connect

    Berven, B.A.

    1993-09-01

    This is a progress report from the Health and Safety Research Division of Oak Ridge National Laboratory. Information is presented in the following sections: Assessment Technology, Biological and Radiation Physics, Chemical Physics, Biomedical and Environmental Information Analysis, Risk Analysis, Center for Risk Management, Associate Laboratories for Excellence in Radiation Technology (ALERT), and Contributions to National and Lead Laboratory Programs and Assignments--Environmental Restoration.

  11. FY2011 Annual Progress Report for Advanced Combustion Engine Research and Development

    SciTech Connect

    none,

    2011-12-01

    Annual Progress Report for the Advanced Combustion Engine Research and Development (R&D) subprogram supporting the mission of the Vehicle Technologies Program by removing the critical technical barriers to commercialization of advanced internal combustion engines (ICEs) for passenger and commercial vehicles that meet future federal emissions regulations.

  12. Efficacy of Abbreviated Progressive Muscle Relaxation Training: A Quantitative Review of Behavioral Medicine Research.

    ERIC Educational Resources Information Center

    Carlson, Charles R.; Hoyle, Rick H.

    1993-01-01

    Conducted quantitative review of research in which abbreviated progressive muscle relaxation training (APRT) was used as intervention for psychophysiological and stress-related disorders. Calculated strength of association between APRT and outcome measures for 29 experiments published after 1980. APRT was most strongly associated with improvement…

  13. Research in the geosciences related to resource assessment. Interim progress report

    SciTech Connect

    Kivelson, M.G.

    1980-07-18

    Research progress is reported in the following subject areas: (1) development of a field data acquisition and processing system for use in exploration geophysics; (2) analysis of seismic data from Imperial Valley and Mt. Etna; and (3) the genesis of uranium ore deposits. (ACR)

  14. Researchers' Bibliography for Raven's Progressive Matrices and Mill Hill Vocabulary Scales.

    ERIC Educational Resources Information Center

    Court, J. H., Comp.

    This annotated bibliography enables researchers who are using Raven's Progressive Matrices or the Mill Hill Vocabulary Scales to become familiar with other work that used these tests. The bibliography derives from Raven's own collection of sources, updated to the end of 1971. The major division of material is by tests rather than subject areas;…

  15. Savannah River Ecology Laboratory annual technical progress report of ecological research, period ending July 31, 1993

    SciTech Connect

    Vaitkus, M.R.; Wein, G.R.; Johnson, G.

    1993-11-01

    This progress report gives an overview of research programs at the Savannah River Site. Topics include; environmental operations support, wood stork foraging and breeding, defense waste processing, environmental stresses, alterations in the environment due to pollutants, wetland ecology, biodiversity, pond drawdown studies, and environmental toxicology.

  16. Los Alamos Life Sciences Division's biomedical and environmental research programs. Progress report, January-December 1980

    SciTech Connect

    Holland, L.M.; Stafford, C.G.; Bolen, S.K.

    1981-09-01

    Highlights of research progress accomplished in the Life Sciences Division during the year ending December 1980 are summarized. Reports from the following groups are included: Toxicology, Biophysics, Genetics; Environmental Pathology, Organic Chemistry, and Environmental Sciences. Individual abstracts have been prepared for 46 items for inclusion in the Energy Data Base. (RJC)

  17. Health and Safety Research Division progress report for the period April 1, 1990--September 30, 1991

    SciTech Connect

    Kaye, S.V.

    1992-03-01

    This is a brief progress report from the Health and Safety Research Division of Oak Ridge National Laboratory. Information is presented in the following sections: Assessment Technology including Measurement Applications and Development, Pollutant Assessments, Measurement Systems Research, Dosimetry Applications Research, Metabolism and Dosimetry Research and Nuclear Medicine. Biological and Radiation Physics including Atomic, Molecular, and High Voltage Physics, Physics of Solids and Macromolecules, Liquid and Submicron Physics, Analytic Dosimetry and Surface Physics and Health Effects. Chemical Physics including Molecular Physics, Photophysics and Advanced Monitoring Development. Biomedical and Environmental Information Analysis including Human Genome and Toxicology, Chemical Hazard Evaluation and Communication, Environmental Regulations and Remediation and Information Management Technology. Risk Analysis including Hazardous Waste.

  18. Remote sensing of suspended sediment water research: principles, methods, and progress

    NASA Astrophysics Data System (ADS)

    Shen, Ping; Zhang, Jing

    2011-12-01

    In this paper, we reviewed the principle, data, methods and steps in suspended sediment research by using remote sensing, summed up some representative models and methods, and analyzes the deficiencies of existing methods. Combined with the recent progress of remote sensing theory and application in water suspended sediment research, we introduced in some data processing methods such as atmospheric correction method, adjacent effect correction, and some intelligence algorithms such as neural networks, genetic algorithms, support vector machines into the suspended sediment inversion research, combined with other geographic information, based on Bayesian theory, we improved the suspended sediment inversion precision, and aim to give references to the related researchers.

  19. Progress in aeronautical research and technology applicable to civil air transports

    NASA Technical Reports Server (NTRS)

    Bower, R. E.

    1981-01-01

    Recent progress in the aeronautical research and technology program being conducted by the United States National Aeronautics and Space Administration is discussed. Emphasis is on computational capability, new testing facilities, drag reduction, turbofan and turboprop propulsion, noise, composite materials, active controls, integrated avionics, cockpit displays, flight management, and operating problems. It is shown that this technology is significantly impacting the efficiency of the new civil air transports. The excitement of emerging research promises even greater benefits to future aircraft developments.

  20. [Recent research progress on the biomining bacteria of Acidithiobacillus caldus--a review].

    PubMed

    Pang, Xin; Chen, Dandan; Lin, Jianqun; Liu, Xiangmei; Lin, Jianqiang; Yan, Wangming

    2009-11-01

    Acidithiobacillus caldus (A. caldus) is one of the predominant biomining bacteria, which shows application prospect in biological metallurgy. It can enhance the biomining efficiency together with iron oxidation bacteria in mixed biomining system. Based on the published papers and our study on this bacterium, we described the research progress on it from four aspects, including the biomining mechanism, arsenic-resistant mechanism, genome study and genetic reconstruction. Furthermore, we discussed the prospects of research on A. caldus. PMID:20112666

  1. Design-Based Research: A Decade of Progress in Education Research?

    ERIC Educational Resources Information Center

    Anderson, Terry; Shattuck, Julie

    2012-01-01

    Design-based research (DBR) evolved near the beginning of the 21st century and was heralded as a practical research methodology that could effectively bridge the chasm between research and practice in formal education. In this article, the authors review the characteristics of DBR and analyze the five most cited DBR articles from each year of this…

  2. Progress of applied superconductivity research at Materials Research Laboratories, ITRI (Taiwan)

    NASA Technical Reports Server (NTRS)

    Liu, R. S.; Wang, C. M.

    1995-01-01

    A status report based on the applied high temperature superconductivity (HTS) research at Materials Research Laboratories (MRL), Industrial Technology Research Institute (ITRI) is given. The aim is to develop fabrication technologies for the high-TC materials appropriate to the industrial application requirements. To date, the majorities of works have been undertaken in the areas of new materials, wires/tapes with long length, prototypes of magnets, large-area thin films, SQUID's and microwave applications.

  3. Research in theoretical elementary particle physics at the University of Florida: Task A. Annual progress report

    SciTech Connect

    Field, R.D.; Ramond, P.M.; Sikivie, P.; Thorn, C.B.

    1994-12-01

    This is the Annual Progress Report of the theoretical particle theory group at the University of Florida under DOE Grant DE-FG05-86ER40272. At present our group consists of four Full Professors (Field, Ramond, Thorn, Sikivie), one Associate Professor (Woodard), and two Assistant Professors (Qiu, Kennedy). In addition, we have four postdoctoral research associates and seven graduate students. The research of our group covers a broad range of topics in theoretical high energy physics including both theory and phenomenology. Included in this report is a summary of the last several years, an outline of our current research program.

  4. Mass Distribution and Mass Transport in the Earth System: Recent Scientific Progress Due to Interdisciplinary Research

    NASA Astrophysics Data System (ADS)

    Kusche, Jürgen; Klemann, Volker; Sneeuw, Nico

    2014-11-01

    This Special Issue on "Mass Distribution and Mass Transport in the Earth System: Recent Scientific Progress due to Interdisciplinary Research" reports a number of findings resulting from a collaborative effort run from 2006 until 2013, in the framework of the DFG Priority Program 1257 "Mass Distribution and Mass Transport in the Earth System". Contributions have been arranged along five lines, i.e. (1) improvements in geodesy: satellite mass monitoring through gravimetry and altimetry, (2) applications in large-scale hydrology, (3) applications in solid Earth research, (4) applications in cryospheric research, (5) applications in ocean sciences.

  5. UCLA accelerator research and development. Progress report, [November 1, 1991--July 31, 1992

    SciTech Connect

    Cline, D.B.

    1992-09-01

    This progress report covers work supported by the above DOE grant over the period November 1, 1991 to July 31, 1992. The work is a program of experimental and theoretical studies in advanced particle accelerator research and development for high energy physics applications. The program features research at particle beam facilities in the United States and includes research on novel high power sources, novel focussing systems (e.g. plasma lens), beam monitors, novel high brightness, high current gun systems, and novel flavor factories in particular the {phi} Factory.

  6. Health and Safety Research Division progress report, October 1, 1988--March 31, 1990

    SciTech Connect

    Not Available

    1990-09-01

    The Health and Safety Research Division (HASRD) of the Oak Ridge National Laboratory (ORNL) continues to maintain an outstanding program of basic and applied research displaying a high level of creativity and achievement as documented by awards, publications, professional service, and successful completion of variety of projects. Our focus is on human health and the scientific basis for measurement and assessment of health-related impacts of energy technologies. It is our custom to publish a division progress report every 18 months that summarizes our programmatic progress and other measures of achievement over the reporting period. Since it is not feasible to summarize in detail all of our work over the period covered by this report (October 1, 1988, to March 30, 1990), we intend this document to point the way to the expensive open literature that documents our findings. During the reporting period the Division continued to maintain strong programs in its traditional areas of R D, but also achieved noteworthy progress in other areas. Much of the Division's work on site characterization, development of new field instruments, compilation of data bases, and methodology development fits into this initiative. Other new work in tunneling microscopy in support of DOE's Human Genome Program and the comprehensive R D work related to surface-enhanced Raman spectroscopy have attained new and exciting results. These examples of our progress and numerous other activities are highlighted in this report.

  7. Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

    PubMed Central

    Heaney, Liam G; Djukanovic, Ratko; Woodcock, Ashley; Walker, Samantha; Matthews, John G; Pavord, Ian D; Bradding, Peter; Niven, Robert; Brightling, Chris E; Chaudhuri, Rekha; Arron, Joseph R; Choy, David F; Cowan, Douglas; Mansur, Adel; Menzies-Gow, Andrew; Adcock, Ian; Chung, Kian F; Corrigan, Chris; Coyle, Peter; Harrison, Timothy; Johnston, Sebastian; Howarth, Peter; Lordan, James; Sabroe, Ian; Bigler, Jeannette; Smith, Dirk; Catley, Matthew; May, Richard; Pierre, Lisa; Stevenson, Chris; Crater, Glenn; Keane, Frank; Costello, Richard W; Hudson, Val; Supple, David; Hardman, Tim

    2016-01-01

    The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite biomarker strategy to optimise CS dose; this will also address what proportion of patients with severe asthma have persistent symptoms without eosinophilic airways inflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies. PMID:26205878

  8. Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

    PubMed

    Heaney, Liam G; Djukanovic, Ratko; Woodcock, Ashley; Walker, Samantha; Matthews, John G; Pavord, Ian D; Bradding, Peter; Niven, Robert; Brightling, Chris E; Chaudhuri, Rekha; Arron, Joseph R; Choy, David F; Cowan, Douglas; Mansur, Adel; Menzies-Gow, Andrew; Adcock, Ian; Chung, Kian F; Corrigan, Chris; Coyle, Peter; Harrison, Timothy; Johnston, Sebastian; Howarth, Peter; Lordan, James; Sabroe, Ian; Bigler, Jeannette; Smith, Dirk; Catley, Matthew; May, Richard; Pierre, Lisa; Stevenson, Chris; Crater, Glenn; Keane, Frank; Costello, Richard W; Hudson, Val; Supple, David; Hardman, Tim

    2016-02-01

    The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite biomarker strategy to optimise CS dose; this will also address what proportion of patients with severe asthma have persistent symptoms without eosinophilic airways inflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies. PMID:26205878

  9. Collisional processes of interest in MFE plasma research. Progress report No. 4, June 1-July 31, 1980

    SciTech Connect

    Olson, R E

    1980-07-31

    Research on this contract can be divided into two general topics: (1) H/sup -/ formation collisions processes, and (2) the determination of scattering cross sections used to diagnose plasma properties. Research progress during the last two months is presented.

  10. [Current Research of the Roles of IL-35 in Tumor Progression].

    PubMed

    Huang, Chongbiao; Tian, Ye; Cui, Yan; Xu, Jie; Xin, Liang; Yang, Xueling; Qi, Daliang

    2016-04-20

    Interleukin(IL)-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the field of immunology. Like other IL-12 superfamily members, IL-35 was a heterodimer which was composed of an α chain P35 and a β chain Epstein-Barr virus induced gene 3 (EBI3). Recent research work revealed two distinct roles of IL-35. Firstly, IL-35 is highly expressed in some kinds of inflammatory diseases and autoimmune diseases and plays import roles in the pathogenesis. Secondly, IL-35 is positively expressed in some cancers and plays some roles in the process of tumor progression. Here we demonstrate the structure and the signalling of IL-35. We reviewed the the roles of IL-35 in promoting tumor progression. PMID:27118652

  11. Recent progress and future direction of cancer epidemiological research in Japan.

    PubMed

    Sobue, Tomotaka

    2015-06-01

    In 2006, the Cancer Control Act was approved and a Basic Plan, to Promote the Cancer Control Program at the national level, was developed in 2007. Cancer research is recognized as a fundamental component to provide evidence in cancer control program. Cancer epidemiology plays central role in connecting research and policy, since it directly deals with data from humans. Research for cancer epidemiology in Japan made substantial progress, in the field of descriptive studies, cohort studies, intervention studies and activities for summarizing evidences. In future, promoting high-quality large-scale intervention studies, individual-level linkage studies, simulation models and studies for elderly population will be of great importance, but at the same time research should be promoted in well-balanced fashion not placing too much emphasis on one particular research field. PMID:25762798

  12. Aeroelasticity at the NASA Langley Research Center Recent progress, new challenges

    NASA Technical Reports Server (NTRS)

    Hanson, P. W.

    1985-01-01

    Recent progress in aeroelasticity, particularly at the NASA Langley Research Center is reviewed to look at the questions answered and questions raised, and to attempt to define appropriate research emphasis needed in the near future and beyond. The paper is focused primarily on the NASA Langley Research Center (LaRC) Program because Langley is the lead NASA center for aerospace structures research, and essentially is the only one working in depth in the area of aeroelasticity. Historical trends in aeroelasticity are reviewed broadly in terms of technology and staffing particularly at the LaRC. Then, selected studies of the Loads and Aeroelasticity Division at LaRC and others over the past three years are presented with attention paid to unresolved questions. Finally, based on the results of these studies and on perceptions of design trends and aircraft operational requirements, future research needs in aeroelasticity are discussed.

  13. Applied nuclear science research and development progress report, June 1, 1985-November 30, 1985

    SciTech Connect

    Arthur, E.D.; Mutschlecner, A.D.

    1986-04-01

    This six month progress report reviews activities in nuclear reaction research. Specific content includes theory and evaluation of nuclear cross sections for neutron, proton, and deuteron reactions for a number of isotopes; the processing and testing of nuclear cross section data; studies of neutron activation, fission products and actinides; and short notes on applications. Data are included in graphic and tabular form and include experimental, evaluated, and theoretical calculations and spectra. 136 refs., 81 figs., 17 tabs. (DWL)

  14. Maryland Controlled Fusion Research Program. Progress report, November 1, 1992--October 31, 1995

    SciTech Connect

    Antonsen, T.M. Jr.; Drake, J.F.; Guzdar, P.; Hassam, A.; Liu, C.S.; Ott, E.

    1995-05-01

    In the past three years, members of the Maryland Plasma Theory Group have made significant contributions to the national fusion theory program, and, in many cases, these theoretical developments helped to interpret experimental results and to design new experimental programs. In this report, they summarize the technical progress in four major areas of tokamak research: (a) L/H transition and edge turbulence and transport; (b) active control of micro-turbulence and transport; (c) major disruptions; and (d) the sawtooth crash.

  15. Maryland controlled fusion research program. Progress report, November 1, 1992--October 31, 1993

    SciTech Connect

    Antonsen, T.M. Jr.; Drake, J.F.; Finn, J.M.; Guzdar, P.; Hassam, A.; Liu, C.S.; Ott, E.

    1993-05-01

    In recent years, members of the Maryland Plasma Theory Group have made significant contributions to the national fusion theory program, and, in many cases, these theoretical developments helped to interpret experimental results and to design new experimental programs. In this paper, we summarize the technical progress in four major areas of tokamak research: (a) L/H transition and edge turbulence and transport; (b) active control of micro-turbulence and transport; (c) major disruptions; and (d) the sawtooth crash.

  16. [Progress of researches on lysozyme and its expression in Oncomelania hupensis].

    PubMed

    Zhu, Xiu-an; Huang, Han-tao; Du, Kang; Wang, An-yun; Zhao, Jin-song

    2016-02-01

    Lysozyme generally exists in animals, plants and microorganisms, and it is used as a natural anti-infection material and one of the important non-specific immune factors in organisms. This paper reviews the progress of researches on its classification, gene structure and function, and expression regulation in Oncomelania hupensis, and on the factors affecting its activities in recent years, in order to further discuss its distribution in O. hupensis. PMID:27356422

  17. [Progress in research of detection assay for pathogens causing community acquirerd pneumonia].

    PubMed

    Jiang, L X; Ren, H Y; Zhou, H J; Chen, Y; Shao, Z J; Qin, T

    2016-07-01

    Community-acquired pneumonia(CAP)is a common respiratory infectious disease. The etiologic diagnosis of CAP remains an uneasy task. Early etiologic diagnosis is critical for proper treatment and might improve the prognosis. So, it is important to identify pathogens causing CAP in early time and accurate way with sensitive and effective method. This paper summarizes the recent progress in the research of the detection assay for CAP. PMID:27453123

  18. Access to Archived Astronaut Data for Human Research Program Researchers: Update on Progress and Process Improvements

    NASA Technical Reports Server (NTRS)

    Lee, L. R.; Montague, K. A.; Charvat, J. M.; Wear, M. L.; Thomas, D. M.; Van Baalen, M.

    2016-01-01

    Since the 2010 NASA directive to make the Life Sciences Data Archive (LSDA) and Lifetime Surveillance of Astronaut Health (LSAH) data archives more accessible by the research and operational communities, demand for astronaut medical data has increased greatly. LSAH and LSDA personnel are working with Human Research Program on many fronts to improve data access and decrease lead time for release of data. Some examples include the following: Feasibility reviews for NASA Research Announcement (NRA) data mining proposals; Improved communication, support for researchers, and process improvements for retrospective Institutional Review Board (IRB) protocols; Supplemental data sharing for flight investigators versus purely retrospective studies; Work with the Multilateral Human Research Panel for Exploration (MHRPE) to develop acceptable data sharing and crew consent processes and to organize inter-agency data coordinators to facilitate requests for international crewmember data. Current metrics on data requests crew consenting will be presented, along with limitations on contacting crew to obtain consent. Categories of medical monitoring data available for request will be presented as well as flow diagrams detailing data request processing and approval steps.

  19. The latest progress in sugarcane molecular genetics research at the USDA-ARS, Sugarcane Research Laboratory

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In 2005, two sugar molecular genetics tools were developed in the USDA-ARS, Southeast Area, Sugarcane Research Laboratory at Houma, LA. One is the high throughput fluorescence- and capillary electrophoregrams (CE)-based SSR genotyping tool and the other is single pollen collection and SSR genotyping...

  20. Aerospace Sponsored Research. Progress report, 1 October 1990-30 September 1991

    SciTech Connect

    Not Available

    1991-12-01

    The structure and mission of The Aerospace Corporation's research and development program is coordinated with, and complementary to, that of the Air Force laboratories and other organizations actively working in space-system-related technology. This report presents brief summaries of the results and progress achieved by the Aerospace Sponsored Research program during the period 1 Oct. 1990 through 30 Sep. 1991. The following areas are discussed: electronics and optics; materials properties and processing; space and atmospheric environment; space communication and navigation; surveillance from space; spacecraft and launch vehicle design and operation; spacecraft survivability; and systems architecture, planning, and analysis. Separate abstracts have been prepared for articles in this report.

  1. [Progress in research of reasons for women engaging in commercial sex].

    PubMed

    Du, Yihui; Wang, Zhiping; Fu, Jihua

    2016-01-01

    With the development of economy, increase of cultural exchanges and changes of people's ideology in China, the number of female sex workers (FSWs) increased rapidly under the influence of various social factors. The diverse motivations for women engaging in commercial sex have been observed. Foreign researchers have conducted some surveys of factors associated with female commercial sex, while few such studies were conducted among FSWs in China. This paper summarizes the progress in the research of reasons for women engaging in commercial sex both at home and abroad to provide evidence for future study. PMID:26822661

  2. [Research progress of polyethylene inserts wear measurement and evaluation in total knee arthroplasty].

    PubMed

    Zhao, Feng; Wang, Chuan; Fan, Yubo

    2015-01-01

    Wear of polyethylene (PE) tibial inserts is a significant cause of implant failure of total knee arthroplasty (TKA). PE inserts wear measurement and evaluation is the key in TKA researches. There are many methods to measure insert wear. Qualitative methods such as observation are used to determine the wear and its type. Quantitative methods such as gravimetric analysis, coordinate measuring machines (CMM) and micro-computed tomography (micro-CT) are used to measure the mass, volume and geometry of wear. In this paper, the principle, characteristics and research progress of main insert wear evaluation method were introduced and the problems and disadvantages were analyzed. PMID:26027291

  3. NASA's Human Research Program at The Glenn Research Center: Progress and Opportunities

    NASA Technical Reports Server (NTRS)

    Nall, Marsha; Griffin, DeVon; Myers, Jerry; Perusek, Gail

    2008-01-01

    The NASA Human Research Program is aimed at correcting problems in critical areas that place NASA human spaceflight missions at risk due to shortfalls in astronaut health, safety and performance. The Glenn Research Center (GRC) and partners from Ohio are significant contributors to this effort. This presentation describes several areas of GRC emphasis, the first being NASA s path to creating exercise hardware requirements and protocols that mitigate the effects of long duration spaceflight. Computational simulations will be a second area that is discussed. This includes deterministic models that simulate the effects of spaceflight on the human body, as well as probabilistic models that bound and quantify the probability that adverse medical incidents will happen during an exploration mission. Medical technology development for exploration will be the final area to be discussed.

  4. Applied Analytical Combustion/emissions Research at the NASA Lewis Research Center - a Progress Report

    NASA Technical Reports Server (NTRS)

    Deur, J. M.; Kundu, K. P.; Nguyen, H. L.

    1992-01-01

    Emissions of pollutants from future commercial transports are a significant concern. As a result, the Lewis Research Center (LeRC) is investigating various low emission combustor technologies. As part of this effort, a combustor analysis code development program was pursued to guide the combustor design process, to identify concepts having the greatest promise, and to optimize them at the lowest cost in the minimum time.

  5. Declassification Productivity Research Center: Progress report number 9, April 1--June 30, 1998

    SciTech Connect

    1998-07-01

    This report documents the progress achieved by the Declassification Productivity Research Center (DPRC) during the third quarter of its third year of operations. The DPRC was established at The George Washington University (GWU) as an independent world-class research capability and computer facility to support the DOE Declassification Productivity Initiative (DPI). The original intent of DOE was to provide seed funding for the DPRC, which might be supplemented by other interested agencies as opportunities for research were identified and projects funded. The goal of DPI is to increase the flow of unrestricted government information to the public. To this end, the work at GWU involves both basic and applied research in the areas of (1) system-level declassification process analysis and modeling, (2) development of computer systems to automate declassification processes, including text analysis and interpretation, (3) coordination/integration of new technology into the processes, and (4) development and promulgation of inter-operability and document transfer standards.

  6. High Pressure Low NOx Emissions Research: Recent Progress at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Chi-Ming, Lee; Tacina, Kathleen M.; Wey, Changlie

    2007-01-01

    In collaboration with U.S. aircraft engine companies, NASA Glenn Research Center has contributed to the advancement of low emissions combustion systems. For the High Speed Research Program (HSR), a 90% reduction in nitrogen oxides (NOx) emissions (relative to the then-current state of the art) has been demonstrated in sector rig testing at General Electric Aircraft Engines (GEAE). For the Advanced Subsonic Technology Program (AST), a 50% reduction in NOx emissions relative to the 1996 International Civil Aviation Organization (ICAO) standards has been at demonstrated in sector rigs at both GEAE and Pratt & Whitney (P&W). During the Ultra Efficient Engine Technology Program (UEET), a 70% reduction in NOx emissions, relative to the 1996 ICAO standards, was achieved in sector rig testing at Glenn in the world class Advanced Subsonic Combustion Rig (ASCR) and at contractor facilities. Low NOx combustor development continues under the Fundamental Aeronautics Program. To achieve these reductions, experimental and analytical research has been conducted to advance the understanding of emissions formation in combustion processes. Lean direct injection (LDI) concept development uses advanced laser-based non-intrusive diagnostics and analytical work to complement the emissions measurements and to provide guidance for concept improvement. This paper describes emissions results from flametube tests of a 9- injection-point LDI fuel/air mixer tested at inlet pressures up to 5500 kPa. Sample results from CFD and laser diagnostics are also discussed.

  7. Four centuries on from Bacon: progress in building health research systems to improve health systems?

    PubMed

    Hanney, Stephen R; González-Block, Miguel A

    2014-01-01

    In 1627, Francis Bacon's New Atlantis described a utopian society in which an embryonic research system contributed to meeting the needs of the society. In this editorial, we use some of the aspirations described in New Atlantis to provide a context within which to consider recent progress in building health research systems to improve health systems and population health. In particular, we reflect on efforts to build research capacity, link research to policy, identify the wider impacts made by the science, and generally build fully functioning research systems to address the needs identified. In 2014, Health Research Policy and Systems has continued to publish one-off papers and article collections covering a range of these issues in both high income countries and low- and middle-income countries. Analysis of these contributions, in the context of some earlier ones, is brought together to identify achievements, challenges and possible ways forward. We show how 2014 is likely to be a pivotal year in the development of ways to assess the impact of health research on policies, practice, health systems, population health, and economic benefits.We demonstrate how the increasing focus on health research systems will contribute to realising the hopes expressed in the World Health Report, 2013, namely that all nations would take a systematic approach to evaluating the outputs and applications resulting from their research investment. PMID:25249030

  8. Carbon Dioxide Effects Research and Assessment Program. Carbon Dioxide Research Progress Report, fiscal year 1979

    SciTech Connect

    Dahlman, R. C.; Gross, T.; Machta, L.; Elliott, W.; MacCracken, M.

    1980-04-01

    Research on the global carbon cycle and the effects of increased carbon dioxide on the global climate system is reported. Environmental and societal effects related to CO/sub 2/ and environmental control technology for CO/sub 2/ are also discussed. Lists of research projects and reports and publications of the Carbon Dioxide and Climate Research Program are included. An expanded CO/sub 2/ monitoring network is providing increased coverage for interpretation of patterns of sources and sinks seasonal variability, and documentation of the global growth of CO/sub 2/. Modeling studies emphasized that knowledge of the transport and mixing of surface ocean waters is important in understanding deep oceanic circulation. Initial studies in the equatorial Pacific are helping quantify estimates of the amount of outgassing CO/sub 2/ from tropical waters. During fiscal year 1979, there was a substantial increase in appreciation of the role of the ocean in controlling not only atmospheric CO/sub 2/ concentrations but also the climatic response to changes in concentration. Model simulations of the effect of doubled CO/sub 2/ concentration carried out with fixed ocean temperatures a situation that is possible during perhaps the next 20 years, showed relatively small summer heating over land areas. On the other hand, simulations in which the oceanic temperatures could come into instantaneous equilibrium with atmospheric conditions continued to show global temperature increases of 3 +- 1.5/sup 0/C, accentuated at high latitudes. To improve understanding of possible regional climate changes, there were increased efforts to reconstruct regional climatic patterns prevailing during past warm periods that might serve as analogs of future climatic conditions. Particular attention was directed to the climates of the United States and other countries bordering the North Atlantic Ocean during the warm period 5000 to 7000 years ago.

  9. progressive problemshifts between different research programs in science education: A lakatosian perspective

    NASA Astrophysics Data System (ADS)

    Niaz, Mansoor

    Given the importance of epistemology and philosophy of science, the Lakatos (1970) methodology is particularly suited to evaluate competing research programs in science education. This article has two objectives: (a) to evaluate critically the interpretations of Gilbert and Swift (1985) and Rowell and Dawson (1989), and (b) to postulate a progressive problemshift between Piaget's epistemic subject and Pascual-Leone's metasubject. Regarding the Gilbert and Swift interpretation, it is concluded that the alternative conceptions movement at its present stage of development cannot explain the previous success of its rival (Piagetian school) nor supersede it by a further display of heuristic power as required by Lakatos. If we accept the Rowell and Dawson thesis it would amount to the postulation of Piagetian and integrated (Piagetian and schema) theories as rival research programs. It appears that the Rowell and Dawson approach would enrich Piagetian theory with descriptive content rather than explanatory constructs, and thus would not lead to a progressive problemshift. It is concluded that Pascual-Leone's theory extends Piaget's negative heuristic by introducing antecedent variables, and at the same time enriches the positive heuristic by introducing metasubjective task analysis, which leads to a progressive problemshift.

  10. Accelerating Progress in Eating Disorders Prevention: A Call for Policy Translation Research and Training.

    PubMed

    Austin, S Bryn

    2016-01-01

    The public health burden of eating disorders is well documented, and over the past several decades, researchers have made important advances in the prevention of eating disorders and related problems with body image. Despite these advances, however, several critical limitations to the approaches developed to date leave the field far from achieving the large-scale impact that is needed. This commentary provides a brief review of what achievements in prevention have been made and identifies the gaps that limit the potential for greater impact on population health. A plan is then offered with specific action steps to accelerate progress in high-impact prevention, most compellingly by promoting a shift in priorities to policy translation research and training for scholars through the adoption of a triggers-to-action framework. Finally, the commentary provides an example of the application of the triggers-to-action framework as practiced at the Strategic Training Initiative for the Prevention of Eating Disorders, a program based at the Harvard T. H. Chan School of Public Health and Boston Children's Hospital. Much has been achieved in the nearly 30 years of research carried out for the prevention of eating disorders and body image problems, but several critical limitations undermine the field's potential for meaningful impact. Through a shift in the field's priorities to policy translation research and training with an emphasis on macro-environmental influences, the pace of progress in prevention can be accelerated and the potential for large-scale impact substantially improved. PMID:25880718

  11. Recent Progress in Low-Temperature Research from the Davis Lab at the University of Alberta

    NASA Astrophysics Data System (ADS)

    Davis, John P.; Rojas, Xavier; Yang, Yikai; Duh, Andrej; Popowich, Greg

    2013-03-01

    In this talk I will briefly describe our recent progress towards new low-temperature experiments at the University of Alberta in the Davis Lab. We are currently setting up two nuclear demagnetization fridges - one new cryostat that has two independent 9 T magnets (the second magnet being useful for a double demag stage or combined high field and low temperature experiments). The other fridge is an older unit that is extensively refurbished, with all new pumping systems. We are planning numerous experiments at the intersection of low-temperature physics and nanoscience, including quantum properties of nanomechancial resonators and quantum fluids in confined geometries. Concerning the latter, we have fabricated high quality microfluidic devices suitable for low-temperature research. We will discuss our progress towards quantum fluids measurements using these devices. Generous support from the University of Alberta, Faculty of Science, CFI, NSERC, nanoBridge, CIFAR, and CSEE.

  12. Measuring progress in multirobot research with rating methods--the RoboCup example.

    PubMed

    Shmilovici, Armin; Ramkddam, Foaid; Lopez, Beatriz; de la Rosa, Josep Lluis

    2004-04-01

    Rating the intelligence of artificially made systems is important for measuring progress in scientific and engineering methods. Unfortunately, there is currently no universal agreement about what is considered an intelligent system, and how to measure its intelligence. This research focus on measuring the progress in the robotic technologies deployed for the RoboCup competitions, since one of the original premises of those competitions was to advance the development of intelligent robotic systems. A method used for rating the competence of human chess players is adapted for measuring the advancement in the competence of robotic teams. The results indicate significant yearly improvements in the capabilities of the robotic teams. The same method can be used to indirectly quantify the benefits in specific technology choices. PMID:15376876

  13. Task A: Research in theoretical elementary particle physics at the University of Florida; Annual progress report

    SciTech Connect

    Field, R.D.; Ramond, P.M.; Sikivie, P.; Thorn, C.B.

    1993-11-01

    This is the Annual Progress Report of the theoretical particle theory group at the University of Florida under DoE Grant DE-FG05-86ER40272. At present our group consists of four Full Professors (Field, Ramond, Thorn, Sikivie) and three Assistant Professors (Qiu, Woodard, Kennedy). Dallas Kennedy recently joined our group increasing the Particle Theory faculty to seven. In addition, we have three postdoctoral research associates, an SSC fellow, and eight graduate students. The research of our group covers a broad range of topics in theoretical high energy physics with balance between theory and phenomenology. Included in this report is a summary of the last several years of operation of the group and an outline of our current research program.

  14. Anticipation - the underlying science of sport. Report on research in progress

    NASA Astrophysics Data System (ADS)

    Nadin, Mihai

    2015-05-01

    Professional sport practitioners intuitively acknowledge anticipation. Sports researchers sometimes discuss it. Still, there is little data-based evidence to characterize the role anticipation plays in human performance. Even less documented is the distinction between reaction and anticipation. This text presents the real-time quantification environment developed as an AnticipationScope™. Based on a very large data harvest from this experimental set-up, hypotheses regarding the role of anticipation in sport are advanced. The conclusion is that while preparation and reaction play an important role in sports performance, in the final analysis anticipation distinguishes the professional from other sport practitioners. Work in progress is presented with the aim of engaging the community of researchers in the design of alternative methods for quantifying anticipation and for processing the data. Generalization from sport to human performance is one of the intended outcomes of this research.

  15. New Researches and Application Progress of Commonly Used Optical Molecular Imaging Technology

    PubMed Central

    Chen, Zhi-Yi; Yang, Feng; Lin, Yan; Zhou, Qiu-Lan; Liao, Yang-Ying

    2014-01-01

    Optical molecular imaging, a new medical imaging technique, is developed based on genomics, proteomics and modern optical imaging technique, characterized by non-invasiveness, non-radiativity, high cost-effectiveness, high resolution, high sensitivity and simple operation in comparison with conventional imaging modalities. Currently, it has become one of the most widely used molecular imaging techniques and has been applied in gene expression regulation and activity detection, biological development and cytological detection, drug research and development, pathogenesis research, pharmaceutical effect evaluation and therapeutic effect evaluation, and so forth, This paper will review the latest researches and application progresses of commonly used optical molecular imaging techniques such as bioluminescence imaging and fluorescence molecular imaging. PMID:24696850

  16. Designing and measuring the progress and impact of health research capacity strengthening initiatives

    PubMed Central

    2015-01-01

    Strengthening capacity in poorer countries to generate multi-disciplinary health research and to utilise research findings, is one of the most effective ways of advancing the countries' health and development. This paper explores current knowledge about how to design health research capacity strengthening (RCS) programmes and how to measure their progress and impact. It describes a systematic, evidence-based approach for designing such programmes and highlights some of the key challenges that will be faced in the next 10 years. These include designing and implementing common frameworks to facilitate comparisons among capacity strengthening projects, and developing monitoring indicators that can capture their interactions with knowledge users and their impact on changes in health systems.

  17. [Recent progress in nuclear magnetic resonance spectrum for drug research and development].

    PubMed

    Zhong, Jun; Jiang, Xue-mei

    2015-01-01

    In the process of modern drug research, the new methods and technologies which can detect drug molecules' chemical composition, structure and interaction with biomolecules are always the key scientific problems people care about. Spectra (including IR, UV and NMR) are the most common analytical methods, of which NMR can obtain detailed parameter about the nucleus of organic molecules through researching the laws of nuclear transition in the impact of surrounding chemical environment. The parameter contains rich information about the chemical composition, structure and interaction with other molecules of organic molecules. In many complex environments, such as liquid, solid or gas state, even biological in situ environment, NMR can provide molecules' chemical composition, atomic-resolution three-dimensional structure, information of interaction with each other and dynamic process, especially the information about drug interacting with biomacromolecules. In recent years, the applications of nuclear magnetic resonance spectrum in drug research and development are more and more widespread. This paper reviewed its recent progress in structure and dynamic of targeted biological macromolecules, drug design and screening and drug metabolism in drug research and development. In the first part, we gave a brief introduction of nuclear magnetic resonance technology and its applications in drug research. In the second part, we explained the basic principles briefly and summarized progress in methods and techniques for drug research. In the third part, we discussed applications of nuclear magnetic resonance ir structure and dynamic of targeted biological macromolecules, drug design and screening and drug metabolism in detail. The conclusions were stated in the last part. PMID:25993865

  18. Advanced Research and Technology Development Fossil Energy Materials Program. Quarterly progress report ending June 30, 1984

    SciTech Connect

    Not Available

    1984-08-01

    The objective of the AR and TD Fossil Energy Materials Program is to conduct research and development on materials for fossil energy applications with a focus on the longer-term and generic needs of the various fossil fuel technologies. The program includes research aimed toward a better understanding of materials behavior in fossil energy environments and the development of new materials capable of substantial enhancement of plant operations and reliability. The management of the Program has been decentralized to DOE Oak Ridge Operations Office (ORO) and the Oak Ridge National Laboratory (ORNL) as technical support contractor. A substantial portion of the work on the AR and TD Fossil Energy Materials Program is performed by participating subcontractor organizations. The ORNL Fossil Energy Materials Program Office compiles and issues this combined quarterly progress report from camera-ready copies submitted by each of the participating subcontractor organizations. This report of activities on the program is organized in accordance with a work breakdown structure defined in the AR and TD Fossil Energy Materials Program Plan for FYs 1982 to 1986, in which projects are organized according to fossil energy technologies. It is the intent of the AR and TD Fossil Energy Materials Program to sponsor materials research which is generic to a number of fossil energy technologies. We hope this series of AR and TD Fossil Energy Materials Program quarterly progress reports will aid in the dissemination of information developed on the program.

  19. [Research progress on biology and ecology of Harmonia axyridis Pallas (Coleoptera: Coccinellidae)].

    PubMed

    Wang, Su; Zhang, Run-Zhi; Zhang, Fan

    2007-09-01

    Harmonia axyridis Pallas (Coleoptera: Coccinellidae) with its native in Asia is one of the most important predatory ladybird beetles, and used worldwide as a biological control agent. This paper summarized the recent decades research progress at home and abroad on its life history, reproductive strategies, and predatory and cannibalism behaviors, and analysed the prospects of its utilization. Based on the review of its artificial reproduction, insecticide interaction, and impact as an invasive species, some useful measures were suggested to prevent the beetle from its potential risk to ecological banlance. PMID:18062323

  20. FY2009 Annual Progress Report for Advanced Combustion Engine Research and Development

    SciTech Connect

    none,

    2009-12-01

    Fiscal Year 2009 Annual Progress Report for the Advanced Combustion Engine Research and Development (R&D) subprogram. The Advanced Combustion Engine R&D subprogram supports the mission of the VTP program by removing the critical technical barriers to commercialization of advanced internal combustion engines (ICEs) for passenger and commercial vehicles that meet future Federal emissions regulations. Dramatically improving the efficiency of ICEs and enabling their introduction in conventional as well as hybrid electric vehicles is the most promising and cost-effective approach to increasing vehicle fuel economy over the next 30 years.

  1. FY 2014 Annual Progress Report - Advanced Combustion Engine Research and Development (Book)

    SciTech Connect

    Not Available

    2014-11-01

    In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

  2. Progress of the RERTR (Reduced Enrichment Research and Test Reactor) Program in 1989

    SciTech Connect

    Travelli, A.

    1989-01-01

    The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. After a brief summary of the results which the RERTR Program, in collaboration with its many international partners, had achieved by the end of 1988, the major events, findings, and activities of 1989 are reviewed. The scope of the RERTR Program activities was curtailed, in 1989, by an unexpected legislative restriction which limited the ability of the Arms Control and Disarmament Agency to adequately fund the program. Nevertheless, the thrust of the major planned program activities was maintained, and meaningful results were obtained in several areas of great significance for future work. 15 refs., 12 figs.

  3. [Research progress on medicinal resources of Mylabris and close origin species].

    PubMed

    Zhang, Jianhui; Chen, Jianwei; Li, Xiang

    2009-03-01

    The paper summarizes the research progress on the medicinal resources of Mylabris and close origin species in recent years. Besides the 45 species in 7 genus within Meloidae insects which contain cantharidin, there are also more 9 species in 7 close origin genus containing cantharidin which include Zanna, Fulgora and Lycorma within Fulgoridae of Homoptera, Oxocopis, Heliocis Xanthochroa and Oedemera within Oedemeridae of Coleoptera. New medicinal resources of cantharidin are redundant, there are biological relationships in the biosynthesis of cantharidin, the emerge of cantharidin is related to ecology and there is more attention on the new methods of utilizing Mylabris resources such as living body extraction. PMID:19623996

  4. Nuclear Physics Research at the University of Richmond progress report, November 1, 1992--October 31, 1993

    SciTech Connect

    Vineyard, M.F.; Gilfoyle, G.P.; Major, R.W.

    1993-12-31

    Summarized in this report is the progress achieved during the period from November 1, 1992 to October 31, 1993 under Contract Number DE-FG05-88ER40459. The experimental work described in this report is in electromagnetic and heavy-ion nuclear physics. The effort in electromagnetic nuclear physics is in preparation for the research program at the Continuous Electron Beam Accelerator Facility (CEBAF) and is focussed on the construction and use of the CEBAF Large Acceptance Spectrometer (CLAS). The heavy-ion experiments were performed at the Argonne National Laboratory ATLAS facility and the University of Pennsylvania.

  5. A progress report on the development of an augmentor wing jet STOL research aircraft.

    NASA Technical Reports Server (NTRS)

    Quigley, H. C.; Sinclair, S. R. M.; Nark, T. C., Jr.; O'Keefe, J. V.

    1971-01-01

    The development of the aircraft has progressed to the point where the design of the modifications to the de Havilland C-8A Buffalo is complete and the engines are being tested. The predicted performance shows that the aircraft will be able to take off and land in less than 1500 ft. Simulation studies indicate that the handling qualities of the aircraft, with stability augmentation, will be acceptable for STOL research missions. Special techniques were required, however, for flight path control and transition from cruise to landing configuration .

  6. The Progress of Research Project for Magnetized Target Fusion in China

    NASA Astrophysics Data System (ADS)

    Yang, Xian-Jun

    2015-11-01

    The fusion of magnetized plasma called Magnetized Target Fusion (MTF) is a hot research area recently. It may significantly reduce the cost and size. Great progress has been achieved in past decades around the world. Five years ago, China initiated the MTF project and has gotten some progress as follows: 1. Verifying the feasibility of ignition of MTF by means of first principle and MHD simulation; 2. Generating the magnetic field over 1400 Tesla, which can be suppress the heat conduction from charged particles, deposit the energy of alpha particle to promote the ignition process, and produce the stable magnetized plasma for the target of ignition; 3. The imploding facility of FP-1 can put several Mega Joule energy to the solid liner of about ten gram in the range of microsecond risen time, while the simulating tool has been developed for design and analysis of the process; 4. The target of FRC can be generated by ``YG 1 facility'' while some simulating tools have be developed. Next five years, the above theoretical work and the experiments of MTF may be integrated to step up as the National project, which may make my term play an important lead role and be supposed to achieve farther progress in China. Supported by the National Natural Science Foundation of China under Grant No 11175028.

  7. Decontamination Systems Information and Research Program. Quarterly technical progress report, January 1--March 31, 1994

    SciTech Connect

    Not Available

    1994-05-01

    West Virginia University (WVU) and the US DOE Morgantown Energy Technology Center (METC) entered into a Cooperative Agreement on August 29, 1992 entitled ``Decontamination Systems Information and Research Programs.`` Stipulated within the Agreement is the requirement that WVU submit to METC a series of Technical Progress Reports on a quarterly basis. This report comprises the first Quarterly Technical Progress Report for Year 2 of the Agreement. This report reflects the progress and/or efforts performed on the sixteen (16) technical projects encompassed by the Year 2 Agreement for the period of January 1 through March 31, 1994. In situ bioremediation of chlorinated organic solvents; Microbial enrichment for enhancing in-situ biodegradation of hazardous organic wastes; Treatment of volatile organic compounds (VOCs) using biofilters; Drain-enhanced soil flushing (DESF) for organic contaminants removal; Chemical destruction of chlorinated organic compounds; Remediation of hazardous sites with steam reforming; Soil decontamination with a packed flotation column; Use of granular activated carbon columns for the simultaneous removal of organics, heavy metals, and radionuclides; Monolayer and multilayer self-assembled polyion films for gas-phase chemical sensors; Compact mercuric iodide detector technology development; Evaluation of IR and mass spectrometric techniques for on-site monitoring of volatile organic compounds; A systematic database of the state of hazardous waste clean-up technologies; Dust control methods for insitu nuclear and hazardous waste handling; Winfield Lock and Dam remediation; and Socio-economic assessment of alternative environmental restoration technologies.

  8. National Institute for Petroleum and Energy Research monthly progress report for August 1993

    SciTech Connect

    Not Available

    1993-09-01

    Brief progress reports are presented under the following tasks: energy production research; fuels research; and supplemental Government programs. Energy production research includes: reservoir assessment and characterization; TORIS research support; development of improved microbial flooding methods; development of improved chemical flooding methods; development of improved alkaline flooding methods; development of improved alkaline flooding methods; mobility control and sweep improvement in chemical flooding; gas flood performance prediction improvement; mobility control, profile modification, and sweep improvement in gas flooding; three-phase relative permeability research; thermal processes for light oil recovery; thermal processes for heavy oil recovery; and imaging techniques applied to the study of fluids in porous media. Fuels research covers; development of analytical methodology for analysis of heavy crudes; and thermochemistry and thermophysical properties of organic nitrogen- and diheteroatom-containing compounds. Supplemental Government program includes: feasibility study of heavy oil recovery in the Midcontinent region: Oklahoma, Kansas, and Missouri; surfactant-enhanced alkaline flooding field project; process-engineering property measurements on heavy petroleum components; development and application of petroleum production technologies; upgrade PBO crude oil database; simulation analysis of steam-foam projects; DOE education initiative project; technology transfer to independent producers; compilation and analysis of outcrop data from the Muddy and Almond formations; implementation of oil and gas technology transfer initiative; horizontal well production from fractured reservoirs; chemical EOR workshop; and organization of UNITAR 6th International conference of Heavy Crude and Tar Sands.

  9. [National Institute for Petroleum and Energy Research] monthly progress report for July 1993

    SciTech Connect

    Not Available

    1993-08-01

    Brief progress reports are presented under the following tasks: energy production research; fuels research; and supplemental Government programs. Energy production research includes: reservoir assessment and characterization; TORIS research support; development of improved microbial flooding methods; development of improved chemical flooding methods; development of improved alkaline flooding methods; mobility control and sweep improvement in chemical flooding; gas flood performance prediction improvement; mobility control, profile modification, and sweep improvement in gas flooding; three-phase relative permeability research; thermal processes for light oil recovery; thermal processes for heavy oil recovery; and imaging techniques applied to the study of fluids in porous media. Fuels research covers; development of analytical methodology for analysis of heavy crudes; and thermochemistry and thermophysical properties of organic nitrogen- and diheteroatom-containing compounds. Supplemental Government program includes: microbial-enhanced waterflooding field project; feasibility study of heavy oil recovery in the Midcontinent region: Oklahoma, Kansas, and Missouri; surfactant-enhanced alkaline flooding field project; process-engineering property measurements on heavy petroleum components; development and application of petroleum production technologies; upgrade PBO crude oil database; simulation analysis of steam-foam projects; DOE education initiative project; technology transfer to independent producers; compilation and analysis of outcrop data from the Muddy and Almond formations; implementation of oil and gas technology transfer initiative; horizontal well production from fractured reservoirs; chemical EOR workshop; and organization of UNITAR 6th International conference of Heavy Crude and Tar Sands.

  10. Contracts for field projects and supporting research on enhanced oil recovery. Progress review quarter ending September 30, 1993

    SciTech Connect

    Not Available

    1994-08-01

    Progress reports are presented for the following tasks: chemical flooding--supporting research; gas displacement--supporting research; thermal recovery--supporting research; geoscience technology; resource assessment technology; and field demonstrations in high-priority reservoir classes. A list of available publications is also included.

  11. Contracts for field projects and supporting research on enhanced oil recovery. Progress review No. 71, quarter ending June 30, 1992

    SciTech Connect

    Not Available

    1993-06-01

    Progress reports are presented for the following tasks: chemical flooding--supporting research; gas displacement--supporting research; thermal recovery--supporting research; geoscience technology; resource assessment technology; microbial technology; and novel technology. A list of available publication is also provided.

  12. Substitutes for Bear Bile for the Treatment of Liver Diseases: Research Progress and Future Perspective

    PubMed Central

    Li, Sha; Tan, Hor Yue; Wang, Ning; Hong, Ming; Li, Lei; Cheung, Fan; Feng, Yibin

    2016-01-01

    Bear bile has been a well-known Chinese medicine for thousands of years. Because of the endangered species protection, the concept on substitutes for bear bile was proposed decades ago. Based on their chemical composition and pharmacologic actions, artificial bear bile, bile from other animals, synthetic compounds, and medicinal plants may be the promising candidates to replace bear bile for the similar therapeutic purpose. Accumulating research evidence has indicated that these potential substitutes for bear bile have displayed the same therapeutic effects as bear bile. However, stopping the use of bear bile is a challenging task. In this review, we extensively searched PubMed and CNKI for literatures, focusing on comparative studies between bear bile and its substitutes for the treatment of liver diseases. Recent research progress in potential substitutes for bear bile in the last decade is summarized, and a strategy for the use of substitutes for bear bile is discussed carefully. PMID:27087822

  13. Progress report for the CCT-WG5 high temperature fixed point research plan

    SciTech Connect

    Machin, G.; Woolliams, E. R.; Anhalt, K.; Bloembergen, P.; Sadli, M.; Yamada, Y.

    2013-09-11

    An overview of the progress in High Temperature Fixed Point (HTFP) research conducted under the auspices of the CCT-WG5 research plan is reported. In brief highlights are: Provisional long term stability of HTFPs has been demonstrated. Optimum construction methods for HTFPs have been established and high quality HTFPs of Co-C, Pt-C and Re-C have been constructed for thermodynamic temperature assignment. The major sources of uncertainty in the assignment of thermodynamic temperature have been identified and quantified. The status of absolute radiometric temperature measurement has been quantified through the circulation of a set of HTFPs. The measurement campaign to assign low uncertainty thermodynamic temperatures to a selected set of HTFPs will begin in mid-2012. It is envisaged that this will be complete by 2015 leading to HTFPs becoming routine reference standards for radiometry and high temperature metrology.

  14. [Current research status and progress of stem cells therapy for degenerative intervertebral disc regeneration].

    PubMed

    Xie, Guangyou; Lu, Furong; Yang, Haitao

    2014-12-01

    Low back pain caused by intervertebral disc degeneration is a common clinical chronic disease. The regenerative ability of intervertebral disc tissue is extremely poor. Meanwhile, current treating methods can not fundamentally solve such problems. With the increasing awareness of the mechanism of disc degeneration and the rapid development of the fields of cellular and molecular biology, gene and materials engineering, using stem cells and tissue engineering technology to slow down or reverse the progress of disc degeneration may become possible. The author reviewed the application of stem cells for treating degenerative discs from present researching status and concepts for the future in the combination of researches reported both at home and abroad. PMID:25868271

  15. [Measurement and estimation methods and research progress of snow evaporation in forests].

    PubMed

    Li, Hui-Dong; Guan, De-Xin; Jin, Chang-Jie; Wang, An-Zhi; Yuan, Feng-Hui; Wu, Jia-Bing

    2013-12-01

    Accurate measurement and estimation of snow evaporation (sublimation) in forests is one of the important issues to the understanding of snow surface energy and water balance, and it is also an essential part of regional hydrological and climate models. This paper summarized the measurement and estimation methods of snow evaporation in forests, and made a comprehensive applicability evaluation, including mass-balance methods (snow water equivalent method, comparative measurements of snowfall and through-snowfall, snow evaporation pan, lysimeter, weighing of cut tree, weighing interception on crown, and gamma-ray attenuation technique) and micrometeorological methods (Bowen-ratio energy-balance method, Penman combination equation, aerodynamics method, surface temperature technique and eddy covariance method). Also this paper reviewed the progress of snow evaporation in different forests and its influencal factors. At last, combining the deficiency of past research, an outlook for snow evaporation rearch in forests was presented, hoping to provide a reference for related research in the future. PMID:24697085

  16. Substitutes for Bear Bile for the Treatment of Liver Diseases: Research Progress and Future Perspective.

    PubMed

    Li, Sha; Tan, Hor Yue; Wang, Ning; Hong, Ming; Li, Lei; Cheung, Fan; Feng, Yibin

    2016-01-01

    Bear bile has been a well-known Chinese medicine for thousands of years. Because of the endangered species protection, the concept on substitutes for bear bile was proposed decades ago. Based on their chemical composition and pharmacologic actions, artificial bear bile, bile from other animals, synthetic compounds, and medicinal plants may be the promising candidates to replace bear bile for the similar therapeutic purpose. Accumulating research evidence has indicated that these potential substitutes for bear bile have displayed the same therapeutic effects as bear bile. However, stopping the use of bear bile is a challenging task. In this review, we extensively searched PubMed and CNKI for literatures, focusing on comparative studies between bear bile and its substitutes for the treatment of liver diseases. Recent research progress in potential substitutes for bear bile in the last decade is summarized, and a strategy for the use of substitutes for bear bile is discussed carefully. PMID:27087822

  17. Progress of the Swedish-Australian research collaboration on uncooled smart IR sensors

    NASA Astrophysics Data System (ADS)

    Liddiard, Kevin C.; Ringh, Ulf; Jansson, Christer; Reinhold, Olaf

    1998-10-01

    Progress is reported on the development of uncooled microbolometer IR focal plane detector arrays (IRFPDA) under a research collaboration between the Swedish Defence Research Establishment (FOA), and the Defence Science and Technology Organization (DSTO), Australia. The paper describes current focal plane detector arrays designed by Electro-optic Sensor Design (EOSD) for readout circuits developed by FOA. The readouts are fabricated in 0.8 micrometer CMOS, and have a novel signal conditioning and 16 bit parallel ADC design. The arrays are post-processed at DSTO on wafers supplied by FOA. During the past year array processing has been carried out at a new microengineering facility at DSTO, Salisbury, South Australia. A number of small format 16 X 16 arrays have been delivered to FOA for evaluation, and imaging has been demonstrated with these arrays. A 320 X 240 readout with 320 parallel 16 bit ADCs has been developed and IRFPDAs for this readout have been fabricated and are currently being evaluated.

  18. Language Research in Progress: Report No. 7, January 1969; A Cross-Referenced List of Documented Language Research Projects Current April 1968 - November 1968.

    ERIC Educational Resources Information Center

    Hayes, Alfred S.; Vis, Joan

    This document is the seventh report in the Language Research in Progress (LRIP) series, and lists a wide variety of language-related research projects current between April 1968 and November 1968. Research projects terminated in the six months prior to publication are included as well. Approximately 250 projects in the U.S. and abroad are…

  19. Recent progresses in atmospheric remote sensing research in China —Chinese national report on atmospheric remote sensing research in China during 1999 2003

    NASA Astrophysics Data System (ADS)

    Qiu, Jinhuan; Chen, Hongbin

    2004-06-01

    Progresses of atmospheric remote sensing research in China during 1999 2003 are summarily introduced. This research includes: (1) microwave remote sensing of the atmosphere; (2) Lidar remote sensing; (3) remote sensing of aerosol optical properties; and (4) other research related to atmospheric remote sensing, including GPS remote sensing of precipitable water vapor and radiation model development.

  20. Progress and Prospects in Human Genetic Research into Age-Related Hearing Impairment

    PubMed Central

    Sugiura, Saiko; Ueda, Hiromi; Nakashima, Tsutomu

    2014-01-01

    Age-related hearing impairment (ARHI) is a complex, multifactorial disorder that is attributable to confounding intrinsic and extrinsic factors. The degree of impairment shows substantial variation between individuals, as is also observed in the senescence of other functions. This individual variation would seem to refute the stereotypical view that hearing deterioration with age is inevitable and may indicate that there is ample scope for preventive intervention. Genetic predisposition could account for a sizable proportion of interindividual variation. Over the past decade or so, tremendous progress has been made through research into the genetics of various forms of hearing impairment, including ARHI and our knowledge of the complex mechanisms of auditory function has increased substantially. Here, we give an overview of recent investigations aimed at identifying the genetic risk factors involved in ARHI and of what we currently know about its pathophysiology. This review is divided into the following sections: (i) genes causing monogenic hearing impairment with phenotypic similarities to ARHI; (ii) genes involved in oxidative stress, biologic stress responses, and mitochondrial dysfunction; and (iii) candidate genes for senescence, other geriatric diseases, and neurodegeneration. Progress and prospects in genetic research are discussed. PMID:25140308

  1. Evaluative studies in nuclear medicine research. Progress report, October 1, 1979-June 30, 1980

    SciTech Connect

    Potchen, E.J.

    1980-07-01

    Effort since the last progress report (September 1979) has been directed toward assessing the potential short and long term benefits of continued development and application and medical research of emission computed tomograhy (ECT). This report contains a review of existing ECT technology, including functional descriptions of current and proposed image systems, for both sngle-photon ECT (SPECT) and positron ECT (PECT) approaches. Medical research and clinical topics to which ECT has been, or may be, applied are presented. One such area of investigation involves the effects of stroke. The application of ECT to laboratory research, and to clinical diagnosis and prognosis, of stroke may result in improved management of the disease. An illustration of the potential savings in the cost of management of stroke due to the effects of applied ECT research is included. The results represent a compilation of data collected from conversations with, and conference presentations by, ECT users, researchers and image system designers, and from a review of the literature.

  2. [Research progress of dual inhibitors targeting HIV-1 reverse transcriptase and integrase].

    PubMed

    Liu, Hong; Zhan, Peng; Liu, Xin-Yong

    2013-04-01

    Both reverse transcriptase (RT) and integrase (IN) play crucial roles in the life cycle of HIV-1, which are also key targets in the area of anti-HIV drug research. Reverse transcriptase inhibitors are involved in the most employed drugs used to treat AIDS patients and HIV-infected people, while one of the integrase inhibitors has already been approved by US FDA to appear on the market. Great achievement has been made in the research on both, separately. Recently, much more attention of medicinal chemistry researchers has been attracted to the strategies of multi-target drugs. Compounds with excellent potency against both HIV RT and IN, evidently defined as dual inhibitors targeting both enzymes, have been obtained through considerable significant exploration, which can be classified into two categories according to different strategies. Combinatorial chemistry approach together with high throughput screening methods and multi-target-based virtual screening strategy have been useful tools for identifying selective anti-HIV compounds for long times; Rational drug design based on pharmacophore combination has also led to remarkable results. In this paper, latest progress of both categories in the discovery and structural modification will be covered, with a view to contribute to the career of anti-HIV research. PMID:23833931

  3. Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis

    PubMed Central

    YAN, WAN-JUN; MA, XING-CONG; GAO, XIAO-YAN; XUE, XING-HUAN; ZHANG, SHU-QUN

    2016-01-01

    Breast cancer is one of the most commonly occurring female malignant tumors. According to the 2012 GLOBOCAN statistics, produced by the International Agency for Research On Cancer (‘IARC’), nearly 1.7 million women were diagnosed with breast cancer, with 522,000 related deaths: An increase in the incidence of breast cancer and associated mortality by nearly 18% from 2008. Metastasis is the final step in breast cancer progression, and represents the most common cause of mortality in patients with breast cancer. Therefore, a search for low-toxicity, safe and effective anti-breast cancer drugs in the form of natural compounds has become an intense focus of research. Baicalein, a widely used Chinese herbal medicine, has extensive antitumor activity. The present review briefly describes the research that has been performed on the association between baicalein and breast cancer metastasis, and further illustrates the influence of baicalein on the underlying mechanisms of breast cancer metastasis, adding a novel theory basis for baicalein antitumor research. In conclusion, baicalein may represent a promising target for the prevention and therapy of breast cancer. PMID:27073644

  4. The origins and progress of genomics research on Tef (Eragrostis tef).

    PubMed

    Girma, Dejene; Assefa, Kebebew; Chanyalew, Solomon; Cannarozzi, Gina; Kuhlemeier, Cris; Tadele, Zerihun

    2014-06-01

    Tef, Eragrostis tef (Zucc.) Trotter, is the most important cereal in Ethiopia. Tef is cultivated by more than five million small-scale farmers annually and constitutes the staple food for more than half of the population of 80 million. The crop is preferred by both farmers and consumers due to its beneficial traits associated with its agronomy and utilization. The genetic and phenotypic diversity of tef in Ethiopia is a national treasure of potentially global importance. In order for this diversity to be effectively conserved and utilized, a better understanding at the genomic level is necessary. In the recent years, tef has become the subject of genomic research in Ethiopia and abroad. Genomic-assisted tef improvement holds tremendous potential for improving productivity, thereby benefiting the smallholder farmers who have cultivated and relied on the crop for thousands of years. It is hoped that such research endeavours will provide solutions to some of the age-old problems of tef's husbandry. In this review, we provide a brief description of the genesis and progress of tef genomic research to date, suggest ways to utilize the genomic tools developed so far, discuss the potential of genomics to enable sustainable conservation and use of tef genetic diversity and suggest opportunities for the future research. PMID:24891040

  5. Advanced Gas Turbine Systems Research, Technical Quarterly Progress Report. October 1, 1998--December 31, 1998

    SciTech Connect

    1999-01-19

    Major accomplishments during this reporting period by the Advanced Gas Turbine Systems Research (AGTSR) are: AGTSR submitted FY99 program continuation request to DOE-FETC for $4M; AGTSR submitted program and workshop Formation to the Collaborative Advanced Gas Turbine (CAGT) initiative; AGTSR distributed research accomplishment summaries to DOE-FETC in the areas of combustion, aero-heat transfer, and materials; AGTSR reviewed and cleared research papers with the IRB from Arizona State, Cornell, Wisconsin, Minnesota, Pittsburgh, Clemson, Texas and Georgia Tech; AGTSR prepared background material for DOE-FETC on three technology workshops for distribution at the DOE-ATS conference in Washington, DC; AGTSR coordinated two recommendations for reputable firms to conduct an economic impact analysis in support of new DOE gas turbine initiatives; AGTSR released letters announcing the short-list winners/non-winners from the 98RFP solicitation AGTSR updated fact sheet for 1999 and announced four upcoming workshops via the SCIES web page AGTSR distributed formation to EPRI on research successes, active university projects, and workshop offerings in 1999 AGTSR continued to conduct telephone debriefings to non-winning PI's born the 98RFP solicitation AGTSR distributed completed quarterly progress report assessments to the IRB experts in the various technology areas AGTSR provided Formation to GE-Evandale on the active combustion control research at Georgia Tech AGTSR provided information to AlliedSignal and Wright-Pat Air Force Base on Connecticut's latest short-listed proposal pertaining to NDE of thermal barrier coatings AGTSR submitted final technical reports from Georgia Tech - one on coatings and the other on active combustion control - to the HU3 for review and evaluation AGTSR coordinated the format, presentation and review of 28 university research posters for the ATS Annual Review Meeting in November, 1998 AGTSR published a research summary paper at the ATS Annual

  6. Research in high energy physics. Progress report, 1 July 1993--30 June 1994

    SciTech Connect

    Rosen, J.; Block, M.; Buchholz, D.

    1994-07-01

    Progress on Task A centered around data analysis. E835 is now approved. It will extend E760 studies, exploring new charmonium states and featuring an upgraded detector system plus operation at 4--6 times higher luminosity. Results are given on E760 analysis. Task B has 10 papers that have either appeared in print, or have been prepared for publication. They break down into four categories; experimental physics, theoretical physics, and computer computational techniques. They are described here along with an exciting new experimental proposal to use Da{Phi}ne, the {Phi} factory that is being constructed at Frascati National Laboratory. Progress for Task C which includes participating in the D0 project at TeV I, and the photoproduction experiment, E687, at TeV II is given. While Northwestern is not participating in the top quark physics group at D0, they have been involved in the data analysis and the discussions that led to the limits on the top quark mass. Task D comprises the shared services for the Northwestern DOE contract. This includes the maintenance and operation of all computers within the HEP group. The projects supported by Task D during the past year are given. Task E progress was to resolve the apparent conflict between EMC, SMC, and SLAC results on nucleon structure functions and Bjorken sum rules. Task F covered research in hadronic decay of the tau, thermal field theory, plasma effects in astrophysics, and heavy quarkonium. Task G covers E665, a general purpose muon scattering experiment which can detect both the scattered muon and most charged and neutral hadrons produced in the forward region. The Northwest group has collaborated very closely in the past year with the Harvard group on analyses of structure functions and vector meson production in the 1991 data sample.

  7. The RERTR (Reduced Enrichment Research and Test Reactor) Program: Progress and plans

    SciTech Connect

    Travelli, A.

    1987-01-01

    The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. After a brief summary of the results which the RERTR Program, in collaboration with its many international partners, had achieved by the end of 1986, the activities, results, and new developments which occurred in 1987 are reviewed. Irradiation of the second miniplate series, concentrating on U/sub 3/Si/sub 2/-Al and U/sub 3/Si-Al fuels, was completed and postirradiation examinations were performed on many of its miniplates. The whole-core ORR demonstration with U/sub 3/Si/sub 2/-Al fuel at 4.8 g U/cm/sup 3/ was completed at the end of March with excellent results and with 29 elements estimated to have reached at least 40% average burnup. Good progress was made in the area of LEU usage for the production of fission /sup 99/Mo, and in the coordination of safety evaluations related to LEU conversions of US university reactors. Planned activities include testing and demonstrating advanced fuels intended to allow use of reduced enrichment uranium in very-high-performance reactors. Two candidate fuels are U/sub 3/Si-Al with 19.75% enrichment and U/sub 3/Si/sub 2/-Al with 45% enrichment. Demonstration of these fuels will include irradiation of full-size elements and, possibly, a full-core demonstration. Achievement of the final program goals is still projected for 1990. This progress could not have been possible without the close international cooperation which has existed from the beginning, and which is essential to the ultimate success of the RERTR Program.

  8. Status of the RERTR program: overview, progress and plans. [Reduced Enrighment Research and Test Reactor

    SciTech Connect

    Travelli, A.

    1985-01-01

    The status of the US Reduced Enrichment Research and Test Reactor (RERTR) Program is reviewed. After a summary of the accomplishments which the RERTR Program had achieved by the end of 1984 with its many international partners, emphasis is placed on the progress achieved during 1985 and on current plans and schedules. A new miniplate series, concentrating on U/sub 3/Si/sub 2/-Al and U/sub 3/Si-Al fuels, was fabricated and is well into irradiation. The whole-core ORR demonstration is scheduled to begin in November 1985, with U/sub 3/Si/sub 2/-Al fuel at 4.8 g U/cm/sup 3/. Altogether, 921 full-size test and prototype elements have been ordered for fabrication with reduced enrichment and the new technologies. Qualification of U/sub 3/Si-Al fuel with approx.7 g U/cm/sup 3/ is still projected for 1989. This progress could not have been achieved without the close international cooperation which has existed since the beginning, and whose continuation and intensification will be essential to the achievement of the long-term RERTR goals.

  9. Experimental and theoretical high energy physics research. Annual progress report, September 1, 1991--September 31, 1992

    SciTech Connect

    Not Available

    1992-10-01

    Progress in the various components of the UCLA High-Energy Physics Research program is summarized, including some representative figures and lists of resulting presentations and published papers. Principal efforts were directed at the following: (I) UCLA hadronization model, PEP4/9 e{sup +}e{sup {minus}} analysis, {bar P} decay; (II) ICARUS and astroparticle physics (physics goals, technical progress on electronics, data acquisition, and detector performance, long baseline neutrino beam from CERN to the Gran Sasso and ICARUS, future ICARUS program, and WIMP experiment with xenon), B physics with hadron beams and colliders, high-energy collider physics, and the {phi} factory project; (III) theoretical high-energy physics; (IV) H dibaryon search, search for K{sub L}{sup 0} {yields} {pi}{sup 0}{gamma}{gamma} and {pi}{sup 0}{nu}{bar {nu}}, and detector design and construction for the FNAL-KTeV project; (V) UCLA participation in the experiment CDF at Fermilab; and (VI) VLPC/scintillating fiber R & D.

  10. Recent progress in genetic and epigenetic research on type 2 diabetes

    PubMed Central

    Kwak, Soo Heon; Park, Kyong Soo

    2016-01-01

    Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. During the past decade, progress in genetic association studies has enabled the identification of at least 75 independent genetic loci for T2DM, thus allowing a better understanding of the genetic architecture of T2DM. International collaborations and large-scale meta-analyses of genome-wide association studies have made these achievements possible. However, whether the identified common variants are causal is largely unknown. In addition, the detailed mechanism of how these genetic variants exert their effect on the pathogenesis of T2DM requires further investigation. Currently, there are ongoing large-scale sequencing studies to identify rare, functional variants for T2DM. Environmental factors also have a crucial role in the development of T2DM. These could modulate gene expression via epigenetic mechanisms, including DNA methylation, histone modification and microRNA regulation. There is evidence that epigenetic changes are important in the development of T2DM. Recent studies have identified several DNA methylation markers of T2DM from peripheral blood and pancreatic islets. In this review, we will briefly summarize the recent progress in the genetic and epigenetic research on T2DM and discuss how environmental factors, genetics and epigenetics can interact in the pathogenesis of T2DM. PMID:26964836

  11. Research progress of oncogene and tumor suppressor gene in bladder cancer.

    PubMed

    Zhang, X; Han, C; He, J

    2015-12-01

    Bladder cancer is amongst the most common malignant tumor of the urinary tract system and has the worst outcomes. The factors related to the occurrence and progression of this urological cancer has received considerable research attention. The discovery of marker genes enhances the sensitivity and specificity of early diagnosis and treatment of bladder cancer. Furthermore, these genes can be used as targets for antitumor drugs. Biomarkers that prospectively evaluate disease aggressiveness, progression risk, probability of recurrence and overall prognosis could improve patient care. Integration of molecular markers with conventional pathologic staging of bladder cancers may refine clinical decision making for the selection of adjuvant and salvage therapy. In the past decade, numerous bladder cancer biomarkers have been identified, including various tumor suppressor genes, oncogenes, growth factors, growth factor receptors, hormone receptors, proliferation and apoptosis markers, cell adhesion molecules, stromal factors, and oncoproteins. Several studies on the biological characters and mechanism of the related proteins have provided a theoretical basis for the diagnosis and treatment of bladder cancer. In this review article, we summarized the status of the current studies in this field. PMID:25634585

  12. [Research Progress on role of Abnormal Tryptophan Metabolism in Immune Thrombocytopenia].

    PubMed

    Li, Zhao-Jian; Liu, Xiao-Qian; Xu, Jun-Qing; Chu, Xiao-Xia

    2015-12-01

    Immune thrombocytopenia (ITP) is a common acquired autoimmune hematological disorders. Platelet autoantibodies lead to the decrease of platelet production and (or) increase of its destruction. The latest researches showed that the abnormal tryptophan metabolism mediated by indoleamine-2, 3-dioxygenase(IDO) is related with the pathogenesis of ITP. The patients with ITP show less expression of IDO, reduction of Treg cells and increase of autoreactive T cells and autoantibodies. CTLA-4-Ig can improve the expression of IDO in the patients with ITP, which also can inhibit the proliferation and activation of self-reactive T cells. Thus, clarifying the abnormal tryptophan metabolism mediated by IDO may provide a new idea for improving the understand of the pathogenesis and treatment of ITP. This review focuses on reasearch progress of the tryptophan metabolism mediated by IDO and ITP. PMID:26708916

  13. Progress of nitride fuel cycle research for transmutation of minor actinides

    SciTech Connect

    Arai, Yasuo; Akabori, Mitsuo; Minato, Kazuo

    2007-07-01

    Recent progress of nitride fuel cycle research for transmutation of MA is summarized. Preparation of MA-bearing nitride pellets, such as (Np,Am)N, (Am,Pu)N and (Np,Pu,Am,Cm)N, was carried out. Irradiation behavior of U-free nitride fuel was investigated by the irradiation test of (Pu,Zr)N and PuN+TiN fuels, in which ZrN and TiN were added as a possible diluent material. Further, pyrochemical process of spent nitride fuel was developed by electrorefining in a molten chloride salt and subsequent re-nitridation of actinides in liquid Cd cathode electro-deposits. Nitride fuel cycle for transmutation of MA has been demonstrated in a laboratory scale by the experimental study with MA and Pu. (authors)

  14. Texas Experimental Tokamak: A plasma research facility. Technical progress report, November 1, 1993--October 31, 1994

    SciTech Connect

    Wootton, A.J.

    1994-07-01

    The purpose is to operate and maintain TEXT Upgrade as a complete facility for applied tokamak physics in order to elucidate the mechanisms of working gas, impurity, and thermal transport in tokamaks and in particular to understand the role of turbulence. So that they can continue to study the physics that is most relevant to the fusion program, TEXT completed a significant device upgrade this year. The new capabilities of the device and new and innovative diagnostics were exploited in all main program areas including: (1) configuration studies; (2) electron cyclotron heating physics; (3) improved confinement modes; (4) edge physics/impurity studies; (5) central turbulence and transport; and (6) transient transport. Details of the progress in each of the research areas are described.

  15. Accelerator research studies. Technical progress report, June 1, 1991--May 31, 1992

    SciTech Connect

    Not Available

    1992-02-01

    The Accelerator Research Studies program at the University of Maryland, sponsored by the Department of Energy under grant number DE-FG05-91ER40642, is currently in the first year of a three-year funding cycle. The program consists of the following three tasks: TASK A, Study of Transport and Longitudinal Compression of Intense, High-Brightness Beams, TASK B, Study of Collective Ion Acceleration by Intense Electron Beams and Pseudospark Produced High Brightness Electron Beams; TASK C, Study of a Gyroklystron High-power Microwave Source for Linear Colliders. In this report we document the progress that has been made during the past year for each of the three tasks.

  16. [Research progress on genotype and genotype-associated pathogenesis of Toxoplasma gondii].

    PubMed

    Wang, Lin; Shen, Ji-Long

    2013-08-01

    Toxoplasmosis is a disease caused by the protozoan Toxoplasma gondii, which is widely prevalent in animals and human throughout the world. It causes serious harm to human health and the development of animal husbandry. T. gondii isolates were considered a single species without geographical boundaries. However, high diversity has been revealed within and between T. gondii populations collected from around the world defined by the multi-locus enzyme electrophoresis (MLEE), polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or microsatellite analysis. Different strains of T. gondii may exhibit differences in virulence to mice. This paper summarizes the research progress on the genotypes from T. gondii isolates in different geographic regions around the world, and the relationship between genotype and virulence of T. gondii. PMID:24812887

  17. Research progress on the brewing techniques of new-type rice wine.

    PubMed

    Jiao, Aiquan; Xu, Xueming; Jin, Zhengyu

    2017-01-15

    As a traditional alcoholic beverage, Chinese rice wine (CRW) with high nutritional value and unique flavor has been popular in China for thousands of years. Although traditional production methods had been used without change for centuries, numerous technological innovations in the last decades have greatly impacted on the CRW industry. However, reviews related to the technology research progress in this field are relatively few. This article aimed at providing a brief summary of the recent developments in the new brewing technologies for making CRW. Based on the comparison between the conventional methods and the innovative technologies of CRW brewing, three principal aspects were summarized and sorted, including the innovation of raw material pretreatment, the optimization of fermentation and the reform of sterilization technology. Furthermore, by comparing the advantages and disadvantages of these methods, various issues are addressed related to the prospect of the CRW industry. PMID:27542505

  18. [Research progress in strategy of lateral femoral offset reconstruction in total hip arthroplasty].

    PubMed

    Fan, Qiu-ping; Wang, Bo; Ji, Wei-ping

    2016-02-01

    As an important indicator of total hip arthroplasty (THA) the rate and degree of offset reconstruction play an important role in improving the prognosis and life quality of patients. The reconstruction of femoral offset is closely related to reserved length of calcar femorale, the head and neck length of prosthesis, angle degree of neck shaft and whether lower limb is isometric. Reconstruction strategy includes making a meticulous and standard measurement before the surgery, predicting the reserved length of calcar femorale, selecting a prosthesis with approximate anatomical neck-shaft angle and reconstructing offset by adjusting the head and neck length of the prosthetic during the operation. The aim of this article was to introduce the research progress and influence of offset on hip function, prosthetic wear and postoperative complications such as pain, limp and unequal leg length, and to discuss the reconstruction strategy. PMID:27141794

  19. Accelerator research studies. Technical progress report, June 1, 1992--May 31, 1993

    SciTech Connect

    Not Available

    1993-03-01

    The Accelerator Research Studies program at the University of Maryland, sponsored by the Department of Energy under grant number DE-FG05-91ER40642, is currently in the second year of a three-year funding cycle. The program consists of the following three tasks: TASK A, ``Study of Transport and Longitudinal Compression of Intense, High-Brightness Beams,`` (P.I., M. Reiser); TASK B, ``Study of Collective Ion Acceleration by Intense Electron Beams and Pseudospark Produced High Brightness Electron Beams,`` (Co-P.I.`s, W.W. Destler, M. Reiser, M.J. Rhee, and C.D. Striffler); TASK C, ``Study of a Gyroklystron High-Power Microwave Source for Linear Colliders,`` (Co-P.I.`s, V.L. Granatstein, W. Lawson, M. Reiser, and C.D. Striffler). In this report we document the progress that has been made during the past year for each of the three tasks.

  20. [Research progress in roles of high-risk human papillomavirus E2 protein].

    PubMed

    Wu, En-Qi; Tang, Yuan-Yu

    2014-03-01

    High-risk human papillomavirus (HPV) is the principal cause of various cancers including cervical cancer, anal cancer, vulvar cancer, and some head and neck cancers. In the viral life cycle, by interacting with both viral and host DNA and proteins, the HPV E2 protein plays a pivotal role in viral transcriptional regulation and DNA replication, and it is also associated with modification of various cellular processes, including host gene transcription, RNA processing, apoptosis, ubiquitination, and intracellular trafficking, to create a convenient environment for a replicative cycle of the virus and contribute to the HPV pathogenesis. Elucidating the roles of E2 protein throughout the viral life cycle will improve our understanding of the viral life cycle and pathogenesis and help us identify novel antiviral agents with therapeutic potential. This article reviews the research progress in the structure, roles, and activity of high-risk HPV E2 protein, particularly that of HPV-16. PMID:24923176

  1. Nuclear excitations and reaction mechanisms: a research proposal (renewal) and report of progress

    SciTech Connect

    Fallieros, S.; Levin, F.S.

    1981-07-31

    Research progress is reported on the following subjects: (1) diamagnetism, gauge transformations and sum rules, (2) quantal motion in an electric field, (3) a theorem concerning quadrupole absorption and scattering of photons, (4) excitation of natural parity states by Raman scattering in nuclei, (5) retarded E1 transitions and isoscaler giant dipole resonances, (6) low energy photon scattering from nuclei, (7) few-body models of nuclear reactions, (8) three- and four-nucleon configuration space calculations, (9) time-dependent few-body calculations, (10) atomic and molecular structure calculations, (11) bound state approximations, (12) extended Faddeev theory, (13) configuration-space techniques, and (14) time-dependent approach to scattering problems. (WHK)

  2. Design for energy efficiency: Energy efficient industrialized housing research program. Progress report

    SciTech Connect

    Kellett, R.; Berg, R.; Paz, A.; Brown, G.Z.

    1991-03-01

    Since 1989, the U.S. Department of Energy has sponsored the Energy Efficient Industrialized Housing research program (EEIH) to improve the energy efficiency of industrialized housing. Two research centers share responsibility for this program: The Center for Housing Innovation at the University of Oregon and the Florida Solar Energy Center, a research institute of the University of Central Florida. Additional funding is provided through the participation of private industry, state governments and utilities. The program is guided by a steering committee comprised of industry and government representatives. This report summarizes Fiscal Year (FY) 1990 activities and progress, and proposed activities for FY 1991 in Task 2.1 Design for Energy Efficiency. This task establishes a vision of energy conservation opportunities in critical regions, market segments, climate zones and manufacturing strategies significant to industrialized housing in the 21st Century. In early FY 1990, four problem statements were developed to define future housing demand scenarios inclusive of issues of energy efficiency, housing design and manufacturing. Literature surveys were completed to assess seven areas of influence for industrialized housing and energy conservation in the future. Fifty-five future trends were identified in computing and design process; manufacturing process; construction materials, components and systems; energy and environment; demographic context; economic context; and planning policy and regulatory context.

  3. Progress in burns research: a review of advances in burn pathophysiology.

    PubMed

    Jewo, P I; Fadeyibi, I O

    2015-06-30

    Severe burns trigger a wide range of responses in the victim. Initial vascular changes are followed by hypermetabolic, inflammatory and immunologic changes. The prolonged hypermetabolic response is associated with an elevated resting rate of energy consumption, tissue wasting and altered substrate kinetics. There is increased blood glucose though insulin levels are above normal. The cortisol level is raised and, together with catecholamine, drives the metabolic response. The immune system is typically weakened. There is elevation in blood levels of a wide range of cytokines from activated cells. These agents drive a prolonged inflammatory response which can lead to tissue damage and multiple organ failure. Dynamic fluid resuscitation regimens have cut down mortality from shock in the early post-burn period. However, unbalanced activity of pro- and anti-inflammatory cytokines can leave patients in an immuno-suppressed state that affects outcomes. So far, many treatments, such as propranolol, a cardio-protector, and anabolic agents, such as oxandrolone and growth hormone, have been tried with mixed results. This review focuses on research that elucidated burn pathophysiology. Some clinical areas in which treatment centred on correcting altered physiology were also included. We have highlighted both the challenges and significant findings. Finally, this paper draws attention to the gaps between progress in basic research and clinical application and suggests areas where further research and funding could be focused. PMID:27252608

  4. Complement research in the 18th-21st centuries: Progress comes with new technology.

    PubMed

    Sim, R B; Schwaeble, W; Fujita, T

    2016-10-01

    The complement system has been studied for about 120 years. Progress in defining this large and complex system has been dependent on the research technologies available, but since the introduction of protein chromatography, electrophoresis, and antibody-based assay methods in the 1950s and 60s, and sequencing of proteins and DNA in the 70s and 80s, there has been very rapid accumulation of data. With more recent improvements in 3D structure determination (nmr and X-ray crystallography), the structures of most of the complement proteins have now been solved. Complement research since 1990 has been greatly stimulated by the discoveries of the multiple proteins in the lectin pathway, the strong association of Factor H, C3, Factor B allelic variants with adult macular degeneration and atypical haemolytic uremic syndrome, and the introduction of the anti-C5 monoclonal antibody as a therapy for paroxysmal nocturnal hemoglobinuria and atypical haemolytic uremic syndrome. Potential new roles for complement in tissue development and the search for novel therapeutics suggest a very active future for complement research. PMID:27371361

  5. NRL HIFAR research program annual progress report FY92/93

    SciTech Connect

    1993-12-31

    Progress during this reporting period has spanned several areas ranging from studies of fundamental intense-beam transport physics, including comparisons of simulations with experimental results, to accelerator system design and simulation code development. Performance of the research described here has continued to benefit from the close collaboration with personnel at LBL and LLNL. In addition, studies of the longitudinal and transverse physics, which are jointly supported by the Division of High Energy Physics of the US Department of Energy, have benefitted from collaboration with personnel at the University of Maryland associated with the Maryland transport experiment. The research results supported by this program have been, and will be, actively reported to the scientific community through papers presented at conferences and published in conference proceedings as well as in the refereed literature. The work which has been documented for publication is described, in detail, in copies of the referenced material provided in the Appendix. This work is also summarized briefly in the next section. An additional section describing, in depth, research which has not yet been prepared for publication, is also included. This work investigates the basic nonlinear physics which is important to the design of large aperture magnetic quadrupole transport systems, as well as the numerical requirements for reliable simulation of that physics.

  6. Progress in burns research: a review of advances in burn pathophysiology

    PubMed Central

    Jewo, P.I.; Fadeyibi, I.O.

    2015-01-01

    Summary Severe burns trigger a wide range of responses in the victim. Initial vascular changes are followed by hypermetabolic, inflammatory and immunologic changes. The prolonged hypermetabolic response is associated with an elevated resting rate of energy consumption, tissue wasting and altered substrate kinetics. There is increased blood glucose though insulin levels are above normal. The cortisol level is raised and, together with catecholamine, drives the metabolic response. The immune system is typically weakened. There is elevation in blood levels of a wide range of cytokines from activated cells. These agents drive a prolonged inflammatory response which can lead to tissue damage and multiple organ failure. Dynamic fluid resuscitation regimens have cut down mortality from shock in the early post-burn period. However, unbalanced activity of pro- and anti-inflammatory cytokines can leave patients in an immuno-suppressed state that affects outcomes. So far, many treatments, such as propranolol, a cardio-protector, and anabolic agents, such as oxandrolone and growth hormone, have been tried with mixed results. This review focuses on research that elucidated burn pathophysiology. Some clinical areas in which treatment centred on correcting altered physiology were also included. We have highlighted both the challenges and significant findings. Finally, this paper draws attention to the gaps between progress in basic research and clinical application and suggests areas where further research and funding could be focused. PMID:27252608

  7. 94-1 Research and Development Project lead laboratory support: Fiscal year 1997. Progress report

    SciTech Connect

    McKee, S.D.

    1996-12-01

    On May 26, 1994, the Defense Nuclear Facilities Safety Board (DNFSB) issued Recommendation 94-1, which expressed the board`s concern about nuclear materials left in the manufacturing pipeline after the US halted its nuclear weapons production activities. The DNFSB emphasized the need for remediation of these materials. As part of Recommendation 94-1, the DNFSB defined research objectives as follows: that a research program be established to fill any gaps in the information base needed for choosing among the alternate processes to be used in safe conversion of various types of fissile materials to optimal forms for safe interim storage and the longer-term disposition. To achieve this objective a research and technology development program with two elements is needed: a technology-specific program that is focused on treating and storing materials safety, with concomitant development of storage criteria and surveillance requirements, centered around 3- and 8-year targets; and a core technology program to augment the knowledge base about general chemical and physical processing and storage behavior and to assure safe interim material storage until disposition policies are formulated. The paper reports the progress on the following: materials identification and surveillance; stabilization process development; surveillance and monitoring; core technologies; and project management.

  8. Progress in research, control and elimination of helminth infections in Asia.

    PubMed

    Utzinger, Jürg; Brattig, Norbert W; Leonardo, Lydia; Zhou, Xiao-Nong; Bergquist, Robert

    2015-01-01

    Global health has substantially improved over the past 20 years. In low- and middle-income countries, in particular, great strives have been made in the control of communicable diseases, including helminth infections. Nevertheless, the most marginalised communities still suffer from infectious diseases that are intimately connected with poverty and lack of access to essential commodities and services, such as clean water, improved sanitation and sufficient food. A two-pronged approach is thus necessary: (i) intensifying control in remaining high-endemicity areas and pockets of high transmission; and (ii) moving from morbidity control to interruption of disease transmission in low-endemicity areas with the goal of local elimination. The latter will require new tools and strategies, going hand-in-hand with strong partnerships and new strategic alliances. In this special issue of Acta Tropica, 35 articles are featured that, together, provide an up-to-date overview of the latest progress made in research, control and elimination of helminth infections in East and Southeast Asia. The first 12 articles expound tools and approaches for improved detection, surveillance and monitoring of helminth infections. Control and elimination approaches for the most important helminth infections are revisited in the next 20 articles. The three remaining articles are cross-cutting pieces examining the interface of agriculture, environment and helminth infections and providing a rationale for integrated, multi-sectorial control approaches that are necessary for sustaining helminthiasis control and progressively moving towards elimination. An interesting aspect revealed through an in-depth analysis of the provenance of the 35 contributions is that the People's Republic of China emerges as a key player in global health, which is documented through its prominent role in research and control of helminth infection and networking throughout Asia. Policy implications are discussed and will

  9. Research progress in rehabilitation treatment of stroke patients: A bibliometric analysis☆

    PubMed Central

    Feng, Xiaodong; Liu, Chengmei; Guo, Qingchuan; Bai, Yanjie; Ren, Yafeng; Ren, Binbin; Bai, Junmin; Chen, Lidian

    2013-01-01

    Background: Stroke presents as a transient or chronic brain dysfunction and is associated with high morbidity and high mortality. The doctors and scientists would like to argue how to enhance the validity of the rehabilitation treatment and how to further improve the level of treatment on stroke. Objective: The aim of this study was to quantitatively analyze the current worldwide progress in research on stroke rehabilitation treatment based on Web of Science database and ClinicalTrial.gov in the past 10 years. Methods: We conducted a quantitative analysis of clinical trial articles regarding stroke rehabilitation published in English from 2003 to 2013 and indexed in the National Institutes of Health Clinical Trials registry and Web of Science databases. Data were downloaded on March 15, 2013. Results: (1) From 2003 to 2013, 2 654 clinical trials investigating stroke were indexed in ClinicalTrials.gov. There were only 58 clinical trials registered in 2003, and there was a marked increase from 2005. A total of 605 clinical trials on the rehabilitation of stroke were conducted in the past 10 years. (2) The analysis showed that most of the trials in the field were registered by North American institutions. With respect to the Asian countries, China and Taiwan area of China also published a reasonable proportion of the trials, but comparatively speaking, the number of trials is really rare. Most of the interventions were drugs, followed by the devices, and behavioral interventions were ranked third. (3) In the past 10 years, there were 4 052 studies on stroke indexed by Web of Science database. Conclusion: From perspective of research progress, we found that the number of clinical trials and papers on stroke rehabilitation has increased significantly in the past 10 years, between them a remarkable positive correlation exists. PMID:25206438

  10. Learning Journeys: Learners' Voice. North East Learners' Views on Progress and Achievement in Literacy and Numeracy. Summary Research Report

    ERIC Educational Resources Information Center

    Gregson, Maggie; Spedding, Trish; Banks, Andy; Stewart, Jennifer; Staley, Jim; Edmonds, Catherine

    2004-01-01

    This report describes the processes and findings of a north east Learning and Skills Development Agency (LSDA) research project. This was a collaborative research study, which followed from a similar, much larger project in the north west, which looked into how learners view their own progress and achievement in the acquisition of literacy and…

  11. Twenty-Seventh Quarterly Progress Report of the Research Coordinating Unit (RCU) in Wisconsin. October 1, 1972-December 31, 1972.

    ERIC Educational Resources Information Center

    Wisconsin State Board of Vocational, Technical, and Adult Education, Madison. Research Coordinating Unit.

    A progress report (covering the period October 1, 1972--December 31, 1972) of the Research Coordinating Unit (RCU) of the Wisconsin Board of Vocational, Technical and Adult Education, the report briefly describes activities relating to the accomplishment of objectives and lists research activities. Objectives relate to the stimulation,…

  12. Research progress of on-the-go soil parameter sensors based on NIRS

    NASA Astrophysics Data System (ADS)

    An, Xiaofei; Meng, Zhijun; Wu, Guangwei; Guo, Jianhua

    2014-11-01

    Both the ever-increasing prices of fertilizer and growing ecological concern over chemical run-off into sources of drinking water have brought the issues of precision agriculture and site-specific management to the forefront of present technological development within agriculture and ecology. Soil is an important and basic element in agriculture production. Acquisition of soil information plays an important role in precision agriculture. The soil parameters include soil total nitrogen, phosporus, potassium, soil organic matter, soil moisture, electrical conductivity and pH value and so on. Field rapid acquisition to all the kinds of soil physical and chemical parameters is one of the most important research directions. And soil parameter real-time monitoring is also the trend of future development in precision agriculture. While developments in precision agriculture and site-specific management procedures have made significant in-roads on these issues and many researchers have developed effective means to determine soil properties, routinely obtaining robust on-the-go measurements of soil properties which are reliable enough to drive effective fertilizer application remains a challenge. NIRS technology provides a new method to obtain soil parameter with low cost and rapid advantage. In this paper, research progresses of soil on-the-go spectral sensors at domestic and abroad was combed and analyzed. There is a need for the sensing system to perform at least six key indexes for any on-the-go soil spectral sensor to be successful. The six indexes are detection limit, specificity, robustness, accuracy, cost and easy-to-use. Both the research status and problems were discussed. Finally, combining the national conditions of china, development tendency of on-the-go soil spectral sensors was proposed. In the future, on-the-go soil spectral sensors with reliable enough, sensitive enough and continuous detection would become popular in precision agriculture.

  13. Research progress on mechanisms of male sterility in plants based on high-throughput RNA sequencing.

    PubMed

    Yongming, Liu; Ling, Zhang; Tao, Qiu; Zhuofan, Zhao; Moju, Cao

    2016-08-01

    Male sterility is defined as failing to produce functional pollen during stamen development in plants, and it plays a crucial role in plant reproductive research and hybrid seed production in utilization of crop heterosis. High throughput RNA sequencing (RNA-seq) has been used widely in the study of different fields of life science, as it readily detects all the mRNA and non-coding RNA in cells. Recently, RNA-seq has been reported to be applied in different species and kinds of pollen abortion types in plants, which has contributed to the understanding of the molecular mechanism and metabolic networks of male sterility at the transcription level. In this review, we summarize research progress on the mechanisms of male sterility in plants, focusing on RNA-seq analysis encompassing strategies of RNA library construction, differentially expressed genes and functional characteristics of noncoding RNAs involved in stamen abortion. Furthermore, we also discuss application of transcriptome sequencing technology to elucidate pollen abortion mechanisms and map fertility-related genes. We hope to provide references to the study of male sterility in plants. PMID:27531606

  14. Clusterin: Review of research progress and looking ahead to direction in hepatocellular carcinoma

    PubMed Central

    Xiu, Peng; Dong, Xiao-Feng; Li, Xin-Ping; Li, Jie

    2015-01-01

    Liver cancer, a large proportion of which is hepatocellular carcinoma (HCC), is diagnosed in more than 700000 people each year worldwide. Liver cancer is particularly prevalent in Asia, Sub-Saharan Africa and the South Pacific, where hepatitis B and hepatitis C infection rates are very high. However, due to resistance to chemotherapy, patients with intermediate and advanced-stage disease cannot benefit from this treatment. Clusterin, which is overexpressed in many different cancers, is a stress-induced cytoprotective protein that confers treatment resistance. Custirsen (OGX-011) is a novel 2’-methoxyethyl modified phosphorothioate antisense oligonucleotide that targets secretory clusterin protein expression and is currently in clinical trials for patients with different cancers. In recent years, a number of different clinical trials have been performed, and two phase III clinical trials of custirsen evaluating combinations with chemotherapy in patients with metastatic castration-resistant prostate cancer and metastatic non-small cell lung cancer are currently in progress. The aims of this review are to summarize the current state of research on clusterin, predict future research directions and analyze the potential of the clinical application of custirsen in HCC. PMID:26217078

  15. Amorphous silicon research: Phase II. Annual technical progress report, August 1, 1995--July 31, 1996

    SciTech Connect

    Guha, S

    1996-10-01

    This report describes the research performed during Phase II of a three-phase, three-year program under NREL Subcontract No. ZAN-4-13318-02. The research program is intended to expand, enhance and accelerate knowledge and capabilities for the development of high-performance, two-terminal multijunction hydrogenated amorphous silicon (a-Si:H) alloy modules. It is now well recognized that a multifunction, multibandgap approach has the potential of achieving the highest stable efficiency in a-Si:H alloy solar cells. In this approach, the bandgap of the materials of the component cell is varied in order to capture a wide spectrum of the solar photons. Significant progress has been made in the development of materials and cell design in the last few years, and a stable module efficiency of 10.2% has been demonstrated over one-square-foot area using a triple-junction approach in which the bottom two component cells use hydrogenated amorphous silicon-germanium (a-SiGe:H) alloy. In order to meet the Department of Energy goal of achievement of 12% stable module efficiency, it is necessary to make further improvements in each of the component cells. This has been the thrust of the current program.

  16. Research progress of plant population genomics based on high-throughput sequencing.

    PubMed

    Yunsheng, Wang

    2016-08-01

    Population genomics, a new paradigm for population genetics, combine the concepts and techniques of genomics with the theoretical system of population genetics and improve our understanding of microevolution through identification of site-specific effect and genome-wide effects using genome-wide polymorphic sites genotypeing. With the appearance and improvement of the next generation high-throughput sequencing technology, the numbers of plant species with complete genome sequences increased rapidly and large scale resequencing has also been carried out in recent years. Parallel sequencing has also been done in some plant species without complete genome sequences. These studies have greatly promoted the development of population genomics and deepened our understanding of the genetic diversity, level of linking disequilibium, selection effect, demographical history and molecular mechanism of complex traits of relevant plant population at a genomic level. In this review, I briely introduced the concept and research methods of population genomics and summarized the research progress of plant population genomics based on high-throughput sequencing. I also discussed the prospect as well as existing problems of plant population genomics in order to provide references for related studies. PMID:27531607

  17. [Research Progress on Co-stimulating Molecule B7-H3 in Hematological Malignancies].

    PubMed

    Zhang, Wei; Wang, Jing; Ke, Xiao-Yan

    2015-12-01

    Costimulatory molecule B7-H3 is a new member of the B7 immunoregulatory family identified in 2001. Although B7-H3 mRNA is widely detected in a variety of lymphoid and nonlymphoid organs, but the B7-H3 protein is distributed limitedly, generally absent or low expressed in normal tissues. The triggering receptor expressed on myeloid cell (TREM)-like transcript 2 (TLT-2) is a possible receptor for B7-H3, but it is not confirmed. B7-H3 has an important immunologic function having costimulatory or coinhibitory immunoregulatory effects in adaptive immune responses, but its exact mechanism remains contentious. The recent studies reported that aberrant overexpression of B7-H3 was found in a wide range of solid cancer tissues and cells, and associated with more advanced disease and poor prognosis, and directly performed nonimmunological functions in oncogenesis. However, more and more studies demonstrate that B7-H3 also plays an important role in progression of hematologic malignancies. The overexpression of B7-H3 is significantly associated with the malignant degree, relapse, progression and prognosis in haematological malignancies. Thus, B7-H3 represents a novel diagnostic marker and potential therapeutic target for cancers. The immunotherapy targeting to B7-H3 become one of the hotspots of recent researches, and some monoclonal antibodies have already entered into clinical trials. This review summarizes the available data on the relationship between B7-H3 and hematologic malignancies, and further focusing on B7-H3 as a potential therapeutic target in these tumors. PMID:26708906

  18. The RERTR (Reduced Enrichment Research and Test Reactor) program: A progress report

    SciTech Connect

    Travelli, A.

    1986-11-01

    The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. After a brief summary of the results which the RERTR Program, in collaboration with its many international partners, had achieved by the end of 1985, the activities, results, and new developments which occurred in 1986 are reviewed. The second miniplate series, concentrating on U/sub 3/Si/sub 2/-Al and U/sub 3/Si-Al fuels, was expanded and its irradiation continued. Postirradiation examinations of several of these miniplates and of six previously irradiated U/sub 3/Si/sub 2/-Al full-size elements were completed with excellent results. The whole-core ORR demonstration with U/sub 3/Si/sub 2/-Al fuel at 4.8 g U/cm/sup 3/ is well under way and due for completion before the end of 1987. DOE removed an important barrier to conversions by announcing that the new LEU fuels will be accepted for reprocessing. New DOE prices for enrichment and reprocessing services were calculated to have minimal effect on HEU reactors, and to reduce by about 8 to 10% the total fuel cycle costs of LEU reactors. New program activities include preliminary feasibility studies of LEU use in DOE reactors, evaluation of the feasibility to use LEU targets for the production of fission-product /sup 99/Mo, and responsibility for coordinating safety evaluations related to LEU conversions of US university reactors, as required by NRC. Achievement of the final program goals is projected for 1990. This progress could not have been achieved without close international cooperation, whose continuation and intensification are essential to the achievement of the ultimate goals of the RERTR Program.

  19. Proceedings of RIKEN BNL Research Center Workshop: Progress in High-pT Physics at RHIC

    SciTech Connect

    Bazilevsky, A.; Bland, L.; Vogelsang, W.

    2010-03-17

    This volume archives the presentations at the RIKEN BNL Research Center workshop 'Progress in High-PT Physics at RHIC', held at BNL in March 2010. Much has been learned from high-p{sub T} physics after 10 years of RHIC operations for heavy-ion collisions, polarized proton collisions and d+Au collisions. The workshop focused on recent progress in these areas by both theory and experiment. The first morning saw review talks on the theory of RHIC high-p{sub T} physics by G. Sterman and J. Soffer, and on the experimental results by M. Tannenbaum. One of the most exciting recent results from the RHIC spin program is the first observation of W bosons and their associated single-spin asymmetry. The new preliminary data were reported on the first day of our workshop, along with a theoretical perspective. There also were detailed discussions on the global analysis of polarized parton distributions, including the knowledge on gluon polarization and the impact of the W-data. The main topic of the second workshop day were single-transverse spin asymmetries and their analysis in terms of transverse-momentum dependent parton distributions. There is currently much interest in a future Drell-Yan program at RHIC, thanks to the exciting physics opportunities this would offer. This was addressed in some of the talks. There also were presentations on the latest results on transverse-spin physics from HERMES and BELLE. On the final day of the workshop, the focus shifted toward forward and small-x physics at RHIC, which has become a cornerstone of the whole RHIC program. Exciting new data were presented and discussed in terms of their possible implications for our understanding of strong color-field phenomena in QCD. In the afternoon, there were discussions of nuclear parton distributions and jet observables, among them fragmentation. The workshop was concluded with outlooks toward the near-term (LHC, JLab) and longer-term (EIC) future. The workshop has been a great success. We had

  20. Research progress on electronic phase separation in low-dimensional perovskite manganite nanostructures

    PubMed Central

    2014-01-01

    Perovskite oxide manganites with a general formula of R1-x AxMnO3 (where R is a trivalent rare-earth element such as La, Pr, Sm, and A is a divalent alkaline-earth element such as Ca, Sr, and Ba) have received much attention due to their unusual electron-transport and magnetic properties, which are indispensable for applications in microelectronic, magnetic, and spintronic devices. Recent advances in the science and technology have resulted in the feature sizes of microelectronic devices based on perovskite manganite oxides down-scaling into nanoscale dimensions. At the nanoscale, low-dimensional perovskite manganite oxide nanostructures display novel physical properties that are different from their bulk and film counterparts. Recently, there is strong experimental evidence to indicate that the low-dimensional perovskite manganite oxide nanostructures are electronically inhomogeneous, consisting of different spatial regions with different electronic orders, a phenomenon that is named as electronic phase separation (EPS). As the geometry sizes of the low-dimensional manganite nanostructures are reduced to the characteristic EPS length scale (typically several tens of nanometers in manganites), the EPS is expected to be strongly modulated, leading to quite dramatic changes in functionality and more emergent phenomena. Therefore, reduced dimensionality opens a door to the new functionalities in perovskite manganite oxides and offers a way to gain new insight into the nature of EPS. During the past few years, much progress has been made in understanding the physical nature of the EPS in low-dimensional perovskite manganite nanostructures both from experimentalists and theorists, which have a profound impact on the oxide nanoelectronics. This nanoreview covers the research progresses of the EPS in low-dimensional perovskite manganite nanostructures such as nanoparticles, nanowires/nanotubes, and nanostructured films and/or patterns. The possible physical origins of the

  1. Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness.

    PubMed

    Xia, Wenjun; Liu, Fei; Ma, Duan

    2016-06-01

    Hearing impairment is considered as the most prevalent impairment worldwide. Almost 600 million people in the world suffer from mild or moderate hearing impairment, an estimated 10% of the human population. Genetic factors play an important role in the pathogenesis of this disorder. Hereditary hearing loss is divided into syndromic hearing loss (associated with other anomalies) and non-syndromic hearing loss (not associated with other anomalies). Approximately 80% of genetic deafness is non-syndromic. On the basis of the frequency of hearing loss, hereditary non-syndromic hearing loss can be divided into high-, mid-, low-, and total-frequency hearing loss. An audiometric finding of mid-frequency sensorineural hearing loss, or a "bowl-shaped" audiogram, is uncommon. Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic midfrequency deafness genes, namely, DFNA10 (EYA4), DFNA8/12 (TECTA), DFNA13 (COL11A2), DFNA44 (CCDC50), have been reported to date. This review summarizes the research progress of the four genes to draw attention to mid-frequency deafness genes. PMID:27142990

  2. Research Progress on Extremely Red Objects at z≈11,2

    NASA Astrophysics Data System (ADS)

    Fang, Guan-Wen; Wang, Min; Ma, Zhong-Yang; Chen, Yang; Kong, Xu

    2015-07-01

    The extremely red objects (EROs) refer to one kind of galaxies selected by using the color indices in optical and near-infrared wavebands (such as I-K>4 mag). The studies indicate that the EROs are comprised of two classes: one stands for the dust-reddened star-forming galaxies with high redshifts, which are reddened by a large amount of dust, they are mainly the younger spiral galaxies and irregular galaxies with stars forming, and called the DGs, another one stands for the high-redshift elliptical galaxies, which are dominated by old stellar populations (≥ 1 Ga), with no or only with weak star formations, and simply called the OGs. The both classes of EROs are very possibly the precursors of nearby massive galaxies, and only represent the different evolutionary histories respectively. This paper has introduced the research progress on the physical properties of different classes of EROs, such as the morphology and structure, spectral feature, clustering, redshift distribution and galaxy count, as well as the direction of future studies in this field.

  3. Research progress in the key device and technology for fiber optic sensor network

    NASA Astrophysics Data System (ADS)

    Liu, Deming; Sun, Qizhen; Lu, Ping; Xia, Li; Sima, Chaotan

    2016-03-01

    The recent research progress in the key device and technology of the fiber optic sensor network (FOSN) is introduced in this paper. An architecture of the sensor optical passive network (SPON), by employing hybrid wavelength division multiplexing/time division multiplexing (WDM/TDM) techniques similar to the fiber communication passive optical network (PON), is proposed. The network topology scheme of a hybrid TDM/WDM/FDM (frequency division multiplexing) three-dimension fiber optic sensing system for achieving ultra-large capacity, long distance, and high resolution sensing performance is performed and analyzed. As the most important device of the FOSN, several kinds of light source are developed, including the wideband multi-wavelength fiber laser operating at C band, switchable and tunable 2 μm multi-wavelength fiber lasers, ultra-fast mode-locked fiber laser, as well as the optical wideband chaos source, which have very good application prospects in the FOSN. Meanwhile, intelligent management techniques for the FOSN including wideband spectrum demodulation of the sensing signals and real-time fault monitoring of fiber links are presented. Moreover, several typical applications of the FOSN are also discussed, such as the fiber optic gas sensing network, fiber optic acoustic sensing network, and strain/dynamic strain sensing network.

  4. Progress in research April 1, 1993--March 31, 1994, Texas A and M University Cyclotron Institute

    SciTech Connect

    1994-07-01

    The period 1 April 1993--31 March 1994 has seen a number of significant developments of the research program as will be noted by the large increase in individual projects reviewed in this annual report. Among the highlights of the K500 experimental program in Sections 1, 2, and 4 are the investigations of excitation energy deposition and of fission dynamics employing both GDR and particle emission probes, measurements of isospin equilibration, studies of (d, {sup 2}He) reactions with the proton spectrometer and of the {beta} decay of {sup 57}Cu with MARS, and the precise studies of ionic charge state distributions using x-ray measurements. Progress in theoretical studies of the nuclear spectral function and the decay of many body systems, on the properties of mesons in hot hadronic matter and on the determination of astrophysical S-factors from experimental studies of very peripheral reactions are presented in Section 3. The status of the LAMPF based MEGA experiment and of the CERN based NA66 experiment, both of which involve institute scientists, is also briefly presented in this report. The shift to a seven day a week operation coupled with installation of cryopanels and more careful temperature control of the cooling water system have resulted in significant improvements in the operational efficiency and beam capabilities. Operating statistics are presented in Section 5.

  5. Research progress of optical H2O sensor with a DFB diode laser

    NASA Astrophysics Data System (ADS)

    Lv, Guangping; Chang, Jun; Wang, Qingpu; Wang, Qiang; Wei, Wei

    2014-06-01

    In the field of near infrared H2O sensing, the acquisition of the absorption signal usually is from a noisy background, thus it is important to adopt an effective signal demodulation method. This study introduced the research progress in the field of trace water vapor detection, covering different individual gas detection techniques. On the basis of the conventional double-beam differential absorption, the division method in voltage and the dual-peak method based on the differential value of two adjacent absorption lines have been studied. Voltage division has an excellent stability to temperature variation, mechanical extrusion, and fiber bend loss. The dual-peak method proved a linear relation with the water vapor concentration, and this method provided a way to measure the concentration at high pressure. Furthermore, the so called balanced ratiometer detection (BRD) was introduced. It has an outstanding self-adjusting capability, and it can also avoid an excess phase difference caused by the current-to-voltage converting circuit, thus this method has a high sensitivity. In addition, the second harmonic technique applied to gas detection was introduced, and for the high-frequency modulation via driving current, 1/ f was suppressed apparently; as a result, this technique realized a better sensitive detection by one to two orders of magnitude.

  6. [Research Progress on the Interaction Effects and Its Neural Mechanisms between Physical Fatigue and Mental Fatigue].

    PubMed

    Zhang, Lixin; Zhang, Chuncui; He, Feng; Zhao, Xin; Qi, Hongzhi; Wan, Baikun; Ming, Dong

    2015-10-01

    Fatigue is an exhaustion state caused by prolonged physical work and mental work, which can reduce working efficiency and even cause industrial accidents. Fatigue is a complex concept involving both physiological and psychological factors. Fatigue can cause a decline of concentration and work performance and induce chronic diseases. Prolonged fatigue may endanger life safety. In most of the scenarios, physical and mental workloads co-lead operator into fatigue state. Thus, it is very important to study the interaction influence and its neural mechanisms between physical and mental fatigues. This paper introduces recent progresses on the interaction effects and discusses some research challenges and future development directions. It is believed that mutual influence between physical fatigue and mental fatigue may occur in the central nervous system. Revealing the basal ganglia function and dopamine release may be important to explore the neural mechanisms between physical fatigue and mental fatigue. Future effort is to optimize fatigue models, to evaluate parameters and to explore the neural mechanisms so as to provide scientific basis and theoretical guidance for complex task designs and fatigue monitoring. PMID:26964325

  7. Jointly sponsored research program. Quarterly technical progress report, October--December 1993

    SciTech Connect

    Deans, H.A.

    1994-05-01

    This is a progress report on work performed by Western Research Institute for the U.S. DOE, Morgantown Energy Technology Center in the period October- December 1993. Tasks addressed include: development and demonstration of a practical electric downhole steam generator for thermal recovery of heavy oil and tar; wetting behavior of selected crude oil/brine/rock systems; coal gasification, power generation, and product market study; the impact of leachate from clean coal technology waste on the stability of clay liners; investigation of coprocessing of heavy oil, automobile shredder residue, and coal; injection into coal seams for simultaneous CO{sub 2} mitigation and enhanced recovery of coalbed methane; optimization of carbonizer operations in the FMC coke process; chemical sensor and field screening technology development; demonstration of the koppelman {open_quotes}series c{close_quotes} process using a batch test unit with Powder River Basin coal as feed; remote chemical sensor development; market assessment and technical feasibility study of PFBC ash use; solid-state NMR analysis and interpretation of naturally and artificially matured kerogens; Crow{trademark} field demonstration with bell lumber and pole; {open_quotes}B{close_quotes} series pilot plant tests; in situ treatment of manufactured gas plant contaminated soils demonstration program.

  8. Current progress in stem cell research and its potential for islet cell transplantation.

    PubMed

    Leung, P S; Ng, K Y

    2013-01-01

    Diabetes is characterized by insulin deficiency concomitant with hyperglycemia due to reduced islet cell mass and/or dysfunction. Currently, insulin replacement is the first-line treatment option for patients with type 1 and a severe form of type 2 diabetes. Treatment by insulin injection is generally effective but nonphysiological, and has the potential of producing chronic complications. On the other hand, islet transplantation can maintain normoglycemia without hypoglycemic side effects, potentially freeing diabetic patients of insulin dependence. In practice, islet transplantation remains hindered by the lack of organ donors and transplant rejection concerns. Recent advances in stem cell research and regenerative medicine, however, offer promise for the clinical application of islet cell transplantation. This review article offers a critical appraisal of current molecular induction approaches, such as directed differentiation, microenvironment induction, and genetic modification, which mimic islet cell development by inducing a variety of stem cells; they include embryonic stem cells, induced pluripotent stem cells, and various tissue-derived stem cells to become functional and transplantable insulin-producing islet cells. Despite good progress, several obstacles remain to be overcome before islet transplantation can be translated into a therapy for human patients, including, but are not limited to, immunogenicity and risk of tumorogenesis. PMID:22834839

  9. A review of major progresses in mesoscale dynamic research in China since 1999

    NASA Astrophysics Data System (ADS)

    Zhou, Xiaoping; Lu, Hancheng; Ni, Yunqi; Tan, Zhemin

    2004-06-01

    Mesoscale research conducted by Chinese meteorologists during the past four years is reviewed. Advances in theoretical studies include (a) mesoscale quasi-balanced and semi-balanced dynamics, derived through scale analysis and the perturbation method which are suitable for describing mesoscale vortices; (b) subcritical instability and vortex-sheet instability; (c) frontal adjustment mechanism and the effect of topography on frontgenesis; and (d) slantwise vorticity development theories, the slantwise vortex equation, and moist potential vorticity (MPV) anomalies with precipitation-related heat and mass sinks and MPV impermeability theorem. From the MPV conservation viewpoint, the transformation mechanism between different scale weather systems is analyzed. Based on the data analysis, a new dew-point front near the periphery of the West Pacific subtropical high is identified. In the light of MPV theory and Q-vector theory, some events associated with torrential rain systems and severe storms are analyzed and diagnosed. Progress in mesoscale numerical simulation has been made in the development of meso-α, meso-β vortices, meso-γ-scale downbursts and precipitation produced by deep convective systems with MM5 and other mesoscale models.

  10. Exploratory research on solvent refined coal liquefaction. Annual technical progress report, January 1-December 31, 1979

    SciTech Connect

    1980-09-01

    This report summarizes the progress of the Exploratory Research on Solvent Refined Coal Liquefaction project by The Pittsburg and Midway Coal Mining Co.'s Merriam Laboratory during 1979. In a series of experiments with varying feed gas composition, low levels (5 to 10 mole %) of carbon monoxide had little effect on the SRC II processing of Pittsburgh Seam coal (Powhatan No. 5 Mine) while higher levels (20 to 40 mole %) resulted in a general degradation of operability and reduced oil yields. Addition of finely divided (approx. 1 ..mu..m) pyrite to the reactive Powhatan coal had little effect on oil yields although the molecular weight of the distillation residue was apparently decreased. When finely divided pyrite and magnetite were added to the less reactive coals from the Loveridge and Blacksville No. 1 Mines (also Pittsburgh Seam), however, substantial increases in oil yields and product quality were obtained. In a comparison of upflow and downflow dissolver configurations with Powhatan coal in the SRC II mode, there was no difference in yields or product quality. A study characterizing specific reactors revealed a significantly higher conversion in the SRC I mode with a reactor approximating plug flow conditions compared to a completely backmixed reactor. In the SRC II mode there was only a slightly higher oil yield with the plug flow reactor.

  11. Replicative Nature of Indian Research, Essence of Scientific Temper, and Future of Scientific Progress*

    PubMed Central

    Singh, Ajai R.; Singh, Shakuntala A.

    2004-01-01

    A lot of Indian research is replicative in nature. This is because originality is at a premium here and mediocrity is in great demand. But replication has its merit as well because it helps in corroboration. And that is the bedrock on which many a fancied scientific hypothesis or theory stands, or falls. However, to go from replicative to original research will involve a massive effort to restructure the Indian psyche and an all round effort from numerous quarters. The second part of this paper deals with the essence of scientific temper,which need not have any basic friendship, or animosity, with religion, faith, superstition and other such entities. A true scientist follows two cardinal rules. He is never unwilling to accept the worth of evidence, howsoever damning to the most favourite of his theories. Second, and perhaps more important, for want of evidence, he withholds comment. He says neither yes nor no. Where will Science ultimately lead Man is the third part of this essay. One argument is that the conflict between Man and Science will continue tilleither of them is exhausted or wiped out. The other believes that it is Science which has to be harnessed for Man and not Man used for Science. And with the numerous checks and balances in place, Science will remain an effective tool for man's progress. The essential value-neutrality of Science will have to be supplemented by the values that man has upheld for centuries as fundamental, and which religious thought and moral philosophy have continuously professed. PMID:22815607

  12. Autism research and services for young children: history, progress and challenges.

    PubMed

    Thompson, Travis

    2013-03-01

    For three decades after Leo Kanner's first clinical description, research progress in understanding and treating autism was minimal but since the late 1960s the growth of autism discoveries has been exponential, with a remarkable number of new findings published over the past two decades, in particular. These advances were made possible first by the discovery and dissemination of early intensive behavioural intervention (EIBI) for young children with autism that created the impetus for earlier accurate diagnosis. Other factors influencing the rapid growth in autism research were the first accepted diagnostic test for autism, the Autism Diagnostic Interview and Observation Schedule (ADI and ADOS). Developments in brain imaging and genetic technology combined to create a fuller understanding of the heterogeneity of autism, its multiple aetiologies, very early onset and course, and strategies for treatment. For a significant proportion of children with autism, it appears EIBI may be capable of promoting brain connectivity in specific cerebral areas, which is one of autism's underlying challenges. Disagreements about the most appropriate early intervention approach between developmental and behavioural psychologists have been unproductive and not contributed to advancing the field. Naturalistic behavioural and structured discrete trial methods are being integrated with developmental strategies with promising outcomes. Over these past 30 years, young people with autism have gone from receiving essentially no proactive treatment, resulting in lives languishing in institutions, to today, when half of children receiving EIBI treatment subsequently participate in regular classrooms alongside their peers. The future has entirely changed for young people with autism. Autism has become an eminently treatable condition. The time is overdue to set aside philosophical quarrels regarding theories of child development and apply what we know for the benefit of children with autism

  13. Panel discussion: Progress and plans for magnetic fusion: Summary of comments on recent progress in fusion research at the Oak Ridge National Laboratory

    SciTech Connect

    Sheffield, J.

    1989-01-01

    Progress in fusion research is marked not so much by a few giant steps as by a continual number of small steps, which yield a steady advance toward the goal of producing a fusion reactor. During the past year, there have been two such steps in the Oak Ridge National Laboratory (ORNL) program: the experimental demonstration of access to the second stable region of beta in the Advanced Toroidal Facility (ATF); and the acceleration of a frozen hydrogen pellet by an intense electron beam. This paper discusses these steps.

  14. Research progress of perovskite materials in photocatalysis- and photovoltaics-related energy conversion and environmental treatment.

    PubMed

    Wang, Wei; Tadé, Moses O; Shao, Zongping

    2015-08-01

    photocatalytic activity and/or light adsorption capability. Comments on current and future challenges are also provided. The main purpose of this review paper is to provide a current summary of recent progress in perovskite materials for use in these important areas and to provide some useful guidelines for future development in these hot research areas. PMID:25976276

  15. The Status, Potential and Research Progress of CO2 Storage Worldwide

    NASA Astrophysics Data System (ADS)

    Basava-Reddi, L.; Camps, A.

    2012-04-01

    Energy demand continues to grow and is expected to have increased by 35% by 2035, and CO2 emissions continue to increase with a current pathway to 650ppm by 2050. Carbon dioxide capture and storage (CCS) is considered to be an important carbon dioxide mitigation technology. The IEA CCS Technology Roadmap 2009 based on the 'blue map' scenario predicts that to reach CO2 reduction targets 100 commercial CCS projects is desired by 20201, compared to the G8 target of 20 CCS projects by 2020. A recent analysis of current storage projects and future projections shows the G8 target is possible if adequate resourcing is provided and if CO2-EOR projects are included; however the IEA Roadmap CCS target may be unattainable2. With sufficient funding, 50 projects are achievable by 2025 and 100 projects by 2028 inclusive of CO2-EOR projects, the latter requiring 6 billion Euros of total investment. Project lead times are long, which could be up to 15 years for deep saline formation storage projects, and without sufficient funding the gap between targets and the current number of projects will widen. However, there has been progress. 74 CCS projects have been identified by the Global CCS Institute with 14 large scale integrated projects in the operate and execute phase expressing a total storage capacity of 33 Mtpa: 3 more projects in the execute phase since 2009, and 10 more have announced they will be ready for a final investment decision in the next 12 months hence ready to move to the execute phase3. Explanations of project suspension or cancellation have been predominated by non-technical issues; however there are technical challenges remaining; including injectivity and uncertainty in capacity, particularly for deep saline formations; all of which are being considered by the CCS research community. Other considerations that are currently being assessed are subsurface resource interaction, which includes potential interactions of CO2 storage with hydrocarbon production

  16. Electronics Research Laboratory, Plasma Theory and Simulation Group annual progress report, January 1, 1989--December 31, 1989

    SciTech Connect

    Birdsall, C.K.

    1989-12-31

    This is a brief progress report, covering our research in general plasma theory and simulation, plasma-wall physics theory and simulation, and code development. Reports written in this period are included with this mailing. A publications list plus abstracts for two major meetings are included.

  17. Uranium recovery research sponsored by the Nuclear Regulatory Commission at Pacific Northwest Laboratory. Quarterly progress report, June-September 1983

    SciTech Connect

    Foley, M.G.; Deutsch, W.J.; Gee, G.W.; Hartley, J.N.; Kalkwarf, D.R.; Mayer, D.W.; Nelson, R.W.; Opitz, B.E.; Peterson, S.R.; Serne, R.J.

    1983-11-01

    This report documents progress for the following major research projects: stabilization, engineering, and monitoring alternatives assessment for improving regulation of uranium recovery operations and waste management; attenuation of radon emission from uranium tailings; assessment of leachate movement from uranium mill tailings; and methods of minimizing ground-water contaminants from in-situ leach uranium mining.

  18. National flow cytometry and sorting research resource. Annual progress report, July, 1, 1994--June 30, 1995, Year 12

    SciTech Connect

    Jett, J.H.

    1995-04-27

    Research progress utilizing flow cytometry is described. Topics include: rapid kinetics flow cytometry; characterization of size determinations for small DNA fragments; statistical analysis; energy transfer measurements of molecular confirmation in micelles; and enrichment of Mus spretus chromosomes by dual parameter flow sorting and identification of sorted fractions by fluorescence in-situ hybridization onto G-banded mouse metaphase spreads.

  19. Contracts for field projects and supporting research on enhanced oil recovery. Progress review number 83, quarter ending June 30, 1995

    SciTech Connect

    1996-08-01

    Summaries of 41 research projects on enhanced recovery are presented under the following sections: (1) chemical flooding; (2) gas displacement; (3) thermal recovery; (4) geoscience technology; (5) resource assessment technology; and (6) reservoir classes. Each presentation gives the title of the project, contract number, research facility, contract date, expected completion data, amount of the award, principal investigator, and DOE program manager, and describes the objectives of the project and a summary of the technical progress.

  20. Savannah River Ecology Laboratory, Annual Technical Progress Report of Ecological Research, June 30, 2002

    SciTech Connect

    Paul M. Bertsch,

    2002-06-30

    The Savannah River Ecology Laboratory (SREL) is a research unit of The University of Georgia (UGA) and has been conducting ecological research on the Savannah River Site (SRS) near Aiken, South Carolina for 50 years. The overall mission of the Laboratory is to acquire and communicate knowledge of ecological processes and principles. SREL conducts fundamental and applied ecological research, as well as education and outreach programs, under a Cooperative Agreement with the U.S. Department of Energy (DOE). The Laboratory's research mission during the 2002 fiscal year was fulfilled with the publication of 76 journal articles and book chapters by faculty, technical staff, students, and visiting scientists. An additional 50 journal articles have been submitted or are in press. Other noteworthy events took place as faculty members, staff, and graduate students received awards. These are described in the section titled Special Accomplishments of Faculty, Staff, Students, and Administration on page 51. Notable scientific accomplishments include work conducted on contaminant transport, stable isotopes, sandhills ecology, and phytoremediation: (1) A collaborative study between Dr. Tom Hinton at SREL and scientists at SRTC demonstrated the feasibility of using illite clay to sequester 137Cs in sediments along the P and R reactor cooling canal system, where approximately 3,000 acres of land are contaminated. Overall, the study showed significant decreases in cesium concentrations and bioavailability following the addition of illite with no sign of harm to the ecosystem. While the cesium remains sequestered from the biosphere, its radioactivity decays and the process progresses from contaminant immobilization to remediation. (2) SREL's stable isotope laboratory is now fully functional. Stable isotope distributions in nature can provide important insights into many historical and current environmental processes. Dr. Christopher Romanek is leading SREL's research in this area

  1. Progress in research, April 1, 1991--March 31, 1992, Texas A and M University Cyclotron Institute

    SciTech Connect

    1992-06-01

    Reports on research activities, facility operation, and facility development of the Texas A and M Cyclotron Institute for the period 1 April 1991--31 March 1992 are presented in this document. During the report period, the ECR-K500 Cyclotron Combination operated 4,377 hours. Of this time, 832 hours was used for beam development, 942 hours was used for tuning and optics, and the beam was available for experiments 2,603 hours. This time was used in a variety of studies including elastic and inelastic scattering, projectile break-up, the production and decay of giant resonances, fusion and fission dynamics, intermediate mass fragment emission, e{sup +}e{sup {minus}} production and molecular dissociation. In addition, studies of surfaces and metastable states in highly charged ions were carried out using the ECR source. Completion of two 19-element BaF{sub 2} arrays, of the focal plane detector for the proton spectrometer and installation of the HiLi multidetector have provided significant new experimental capabilities which have been further enhanced by major additions to the computer network. Progress on the Mass Achromat Recoil Spectrometer (MARS) is such that first operation of that device should occur this summer. Funding for installation of the MDM spectrometer was obtained at the beginning of this year. As this report is being completed, the Enge Split Pole Spectrometer is being disassembled and removed to make room for the MDM spectrometer. The split-pole will be shipped to CEBAF for use in experiments there. Installation of the MDM should be completed within the next year. Also expected in the next year is a 92 element plastic-CsI ball.

  2. Nuclear physics research at the University of Richmond. Progress report, November 1, 1994--October 31, 1995

    SciTech Connect

    Vineyard, M.F.; Gilfoyle, G.P.; Major, R.W.

    1995-12-31

    Summarized in this report is the progress achieved during the period from November 1, 1994 to October 31, 1995. The experimental work described in this report is in electromagnetic and heavy-ion nuclear physics. The effort in electromagnetic nuclear physics is in preparation for the research program at the Continuous Electron Beam Accelerator Facility (CEBAF) and is focused on the construction and use of the CEBAF Large Acceptance Spectrometer (CLAS). The heavy-ion experiments were performed at the Argonne National Laboratory ATLAS facility and SUNY, Stony Brook. The physics interests driving these efforts at CEBAF are in the study of the structure, interactions, and nuclear-medium modifications of mesons and baryons. This year, an extension of the experiment to measure the magnetic form factor of the neutron was approved by the CEBAF Program Advisory Committee Nine (PAC9) for beam at 6 GeV. The authors also submitted updates to PAC9 on the experiments to measure inclusive {eta} photoproduction in nuclei and electroproduction of the {Lambda}, {Lambda}*(1520), and f{sub 0}(975). In addition to these experiments, the authors collaborated on a proposal to measure rare radiative decays of the {phi} meson which was also approved by PAC9. Their contributions to the construction of the CLAS include the development of the drift-chamber gas system, drift-chamber software, and controls software. Major has been leading the effort in the construction of the gas system. In the last year, the Hall B gas shed was constructed and the installation of the gas system components built at the University of Richmond has begun. Over the last six years, the efforts in low-energy heavy-ion physics have decreased due to the change in focus to electromagnetic nuclear physics at CEBAF. Most of the heavy-ion work is completed and there are now new experiments planned. Included in this report are two papers resulting from collaborations on heavy-ion experiments.

  3. University of Florida, University research program in robotics. Annual technical progress report

    SciTech Connect

    Crane, C.D. III; Tulenko, J.S.

    1994-05-01

    Progress is reported in the areas of environmental hardening, database, world modeling, vision, man-machine interface, advanced liquid metal reactor inspection robot, and articulated transporter/manipulator system (ATMS) development.

  4. "Progressive Problemshifts" between Different Research Programs in Science Education: A Lakatosian Perspective.

    ERIC Educational Resources Information Center

    Niaz, Mansoor

    1993-01-01

    Concludes that Pascual-Leone's theory extends Piaget's negative heuristic by introducing antecedent variables and at the same time enriches the positive heuristic by introducing metasubjective task analysis, which leads to a progressive problemshift. (Author/PR)

  5. [The research progress in determining lignocellulosic content by near infrared reflectance spectroscopy technology].

    PubMed

    Du, Juan; An, Dong; Xia, Tian; Huang, Yan-Hua; Li, Hong-Chao; Zhang, Yun-Wei

    2013-12-01

    Near infrared reflectance spectroscopy technology, as a new analytic method, can be used to determine the content of lignin, cellulose and hemi-cellulose which is faster, effective, easier to operate, and more accurate than the traditional wet chemical methods. Nowadays it has been widely used in measuring the composition of lignocelluloses in woody plant and herbaceous plant. The domestic and foreign research progress in determining the lignin, cellulose and hemi-cellulose content in woody plant ( wood and bamboo used as papermaking raw materials and wood served as potential biomass energy) and herbaceous plant (forage grass and energy grass) by near infrared reflectance spectroscopy technology is comprehensively summarized and the advances in method studies of measuring the composition of lignocelluloses by near infrared reflectance spectroscopy technology are summed up in three aspects, sample preparation, spectral data pretreatment and wavelength selection methods, and chemometric analysis respectively. Four outlooks are proposed combining the development statues of wood, forage grass and energy grass industry. First of all, the authors need to establish more feasible and applicable models for a variety of uses which can be used for more species from different areas, periods and anatomical parts. Secondly, comprehensive near infrared reflectance spectroscopy data base of grass products quality index needs to be improved to realize on-line quality and process control in grassproducts industry, which can guarantee the quality of the grass product. Thirdly, the near infrared reflectance spectroscopy quality index model of energy plant need to be built which can not only contribute to breed screening, but also improve the development of biomass industry. Besides, modeling approaches are required to be explored and perfected any further. Finally, the authors need to try our best to boost the advancement in the determination method of lignin, cellulose and hemi

  6. Out-of-hospital cardiac arrest: 10 years of progress in research and treatment.

    PubMed

    Hollenberg, J; Svensson, L; Rosenqvist, M

    2013-06-01

    Cardiac disease is the most common cause of mortality in Western countries, with most deaths due to out-of-hospital cardiac arrest (OHCA). In Sweden, 5000-10 000 OHCAs occur annually. During the last decade, the time from cardiac arrest to start of cardiopulmonary resuscitation (CPR) and defibrillation has increased, whereas survival has remained unchanged or even increased. Resuscitation of OHCA patients is based on the 'chain-of-survival' concept, including early (i) access, (ii) CPR, (iii) defibrillation, (iv) advanced cardiac life support and (v) post-resuscitation care. Regarding early access, agonal breathing, telephone-guided CPR and the use of 'track and trigger systems' to detect deterioration in patients' condition prior to an arrest are all important. The use of compression-only CPR by bystanders as an alternative to standard CPR in OHCA has been debated. Based on recent findings, guidelines recommend telephone-guided chest compression-only CPR for untrained rescuers, but trained personnel are still advised to give standard CPR with both compressions and ventilation, and the method of choice for this large group remains unclear and demands for a randomized study. Data have shown the benefit of public access defibrillation for dispatched rescuers (e.g. police and fire fighters) but data are not as strong for the use of automated defibrillators (AEDs) by trained or untrained rescuers. Postresuscitation, use of therapeutic hypothermia, the importance of specific prognostic survival factors in the intensive care unit and the widespread use of percutaneous coronary intervention have all been considered. Despite progress in research and improved treatment regimens, most patients do not survive OHCA. Particular areas of interest for improving survival include (i) identification of high-risk patients prior to their arrest (e.g. early warning symptoms and genes); (ii) increased use of bystander CPR training (e.g. in schools) and simplified CPR techniques; (iii

  7. Nondestructive Evaluation (NDE) research progress in 1988: Proceedings from the ninth annual EPRI NDE information meeting

    SciTech Connect

    Avioli, M.J. Jr.; Dau, G.J.; Liu, S.N.; Stein, J.; Welty, C.S.

    1989-05-01

    The increasing cost of equipment for power generating plants and the potential increases in productivity and safety analysis through rapidly developing Nondestructive Evaluation (NDE) technology led EPRI to initiate a Nondestructive Evaluation Program in 1974. To date, the major focus has been on light water reactor inspection problems; however, increased application to other systems is now underway. This report presents a comprehensive review of the EPRI effort in the NDE area. Most of the report consists of contractor-supplied progress reports on each current project. An organizational plan of the program is presented in overview. In addition, organization from several viewpoints is presented, e.g., in-service inspection operators, R and D personnel, and utility representatives. As the tenth in a planned series of annual progress reports of EPRI-funded NDE activities, this report also serves as the proceedings of the Ninth Annual EPRI NDE Information Meeting held in Charlotte, North Carolina, on November 15--16, 1988. It summarizes significant progress made since the previous EPRI Special Report NP-5490-SR was issued in June 1988. Section 1 contains information about the program organization, and the sections that follow contain contractor-supplied progress reports on each current project. The progress reports are grouped by plant components -- pipe, pressure vessel, and steam generator and boiler tubes. In addition, Part 5 is devoted to discussions of technology transfer.

  8. Nondestructive evaluation research progress in 1989: Proceedings from the tenth annual EPRI NDE information meeting

    SciTech Connect

    Avioli, M.J. Jr.; Behravesh, M.M.; Gehl, S.M.; Liu, S.N.; Stein, J.; Welty, C.S. )

    1990-06-01

    The increasing cost of equipment for power generating plants and the potential increases in productivity and safety available through rapidity developing nondestructive evaluation (NDE) technology led EPRI to initiate a Nondestructive Evaluation Program in 1974. To date, the major focus has been on light water reactor (LWR) inspection problems; however, increased application to other systems is now under way. This report presents a comprehensive review of the EPRI effort in the NDE area. Most of the report consists of contractor-supplied progress reports on each current project. An organizational plan of the program is presented in overview. In addition, organization from several viewpoints is presented, e.g., in-service inspection operators, R D personnel, and utility representatives. As the eleventh in a planned series of annual progress reports of EPRI-funded NDE activities, this report also serves as the proceedings of the Tenth Annual EPRI NDE Information Meeting held in Palo Alto, California, on November 14-15, 1989. It summarizes significant progress made since the previous EPRI Special Report NP-6075-SR was issued in May 1989. Section 1 contains information about the program organization, and the sections that follow contain contractor-supplied progress reports on each current project. The progress reports are grouped by plant components -- pipe and nozzle, pressure vessel, and boilers and steam generators. In addition, Part 5 is devoted to discussions of technology transfer. The individual papers have been cataloged separately.

  9. Chemistry and materials science progress report. Weapons-supporting research and laboratory directed research and development: FY 1995

    SciTech Connect

    1996-04-01

    This report covers different materials and chemistry research projects carried out a Lawrence Livermore National Laboratory during 1995 in support of nuclear weapons programs and other programs. There are 16 papers supporting weapons research and 12 papers supporting laboratory directed research.

  10. Contracts for field projects and supporting research on enhanced oil recovery and improved drilling technology. Progress review No. 34, quarter ending March 31, 1983

    SciTech Connect

    Linville, B.

    1983-07-01

    Progress achieved for the quarter ending March 1983 are presented for field projects and supporting research for the following: chemical flooding; carbon dioxide injection; and thermal/heavy oil. In addition, progress reports are presented for: resource assessment technology; extraction technology; environmental and safety; microbial enhanced oil recovery; oil recovered by gravity mining; improved drilling technology; and general supporting research. (ATT)

  11. Effectiveness of Lee Silverman Voice Treatment (LSVT)[R] on Hypernasality in Non-Progressive Dysarthria: The Need for Further Research

    ERIC Educational Resources Information Center

    Wenke, Rachel J.; Theodoros, Deborah; Cornwell, Petrea

    2010-01-01

    Background: Hypernasality is a common feature of non-progressive dysarthria. However, limited research has investigated the effectiveness of treatments for this impairment. Preliminary research has revealed positive effects on nasalance when using increased loudness in certain non-progressive dysarthric speakers. However, the long-term effects of…

  12. Progress in muscular dystrophy research with special emphasis on gene therapy

    PubMed Central

    SUGITA, Hideo; TAKEDA, Shin’ichi

    2010-01-01

    Duchenne muscular dystrophy (DMD) is an X-linked, progressive muscle-wasting disease caused by mutations in the DMD gene. Since the disease was described by physicians in the 19th century, information about the subject has been accumulated. One author (Sugita) was one of the coworkers who first reported that the serum creatine kinase (CK) level is elevated in progressive muscular dystrophy patients. Even 50 years after that first report, an elevated serum CK level is still the most useful marker in the diagnosis of DMD, a sensitive index of the state of skeletal muscle, and useful to evaluate therapeutic effects. In the latter half of this article, we describe recent progress in the therapy of DMD, with an emphasis on gene therapies, particularly exon skipping. PMID:20689232

  13. CMC Research at NASA Glenn in 2015: Recent Progress and Plans

    NASA Technical Reports Server (NTRS)

    Grady, Joseph E.

    2015-01-01

    An overview of recent research in Ceramic Matrix Composite materials at NASA Glenn Research Center. For presentation at the July 16, 2015 GRC Dialogue Day with Ohio Academia, as part of the establishment of the Ohio Federal Research Network.

  14. Fundamental combustion and diagnostics research at Sandia. Progress report, April-June 1980

    SciTech Connect

    Gusinow, M.A.

    1980-09-01

    The combustion research emphasizes basic research into fundamental problems associated with combustion. The overall program addresses detailed chemistry of combustion, fundamental processes associated with laminar and turbulent flames, development of research techniques specifically applicable to combustion environments, and operation of the user-oriented Combustion Research Facility. The first section of this report contains activities in Combustion Research, the second section contains activities in Molecular Physics and Spectroscopy, and the third section contains activities in Diagnostics Research.

  15. Contracts for field projects and supporting research on enhanced oil recovery. Progress review number 86, quarter ending March 31, 1996

    SciTech Connect

    1997-05-01

    Summaries are presented for 37 enhanced oil recovery contracts being supported by the Department of Energy. The projects are grouped into gas displacement methods, thermal recovery methods, geoscience technology, reservoir characterization, and field demonstrations in high-priority reservoir classes. Each summary includes the objectives of the project and a summary of the technical progress, as well as information on contract dates, size of award, principal investigator, and company or facility doing the research.

  16. Research in elementary particle physics. Progress report, March 1, 1993--February 28, 1994

    SciTech Connect

    Chan, Lai-Him; Haymaker, R.; Imlay, R.; McNeil, R.; Metcalf, W.; Svoboda, R.

    1993-10-01

    Theoretical work on effective action expansion, low-energy models of hadrons and lattice gauge theories is reported. The progress on the electron-proton experiment ZEUS in Germany, LSND neutrino experiment at LAMPF, the Dumand experiment in Hawaii, and the Super Kamiokande experiment in Japan is described. Results from IMB are described.

  17. Education, Industrialization and Technical Progress in Mexico. IIEP Research Report No. 6.

    ERIC Educational Resources Information Center

    Padua, Jorge

    This report attempts to analyze the contributions of the educational system and job training programs to industrialization and technical progress in the Conubal zone of the Lower Balsas River of Mexico. The first of the study's three sections consists of two chapters that provide general background. Chapter 1, "Theories of Development and the Role…

  18. Using Parents and Teachers to Monitor Progress among Children with ASD: A Review of Intervention Research

    ERIC Educational Resources Information Center

    Witmer, Sara E.; Nasamran, Amy; Parikh, Purvi J.; Schmitt, Heather A.; Clinton, Marianne C.

    2015-01-01

    Despite growing knowledge of the effectiveness of various interventions for children with autism spectrum disorders (ASD), it is never clear whether a particular intervention will be effective for a specific child with ASD. Careful monitoring of an individual child's progress is necessary to know whether an intervention is effective. In this…

  19. Applications of computer modeling to fusion research. Progress report, 1988--1989

    SciTech Connect

    Dawson, J.M.

    1989-12-31

    Progress achieved during this report period is presented on the following topics: Development and application of gyrokinetic particle codes to tokamak transport, development of techniques to take advantage of parallel computers; model dynamo and bootstrap current drive; and in general maintain our broad-based program in basic plasma physics and computer modeling.

  20. Progress on stem cell research towards the treatment of Parkinson's disease

    PubMed Central

    2012-01-01

    Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive accumulation of Lewy body inclusions along with selective destruction of dopaminergic (DA) neurons in the nigrostriatal tract of the brain. Genetic studies have revealed much about the pathophysiology of PD, enabling the identification of both biomarkers for diagnosis and genetic targets for therapeutic treatment, which are evolved in tandem with the development of stem cell technologies. The discovery of induced pluripotent stem (iPS) cells facilitates the derivation of stem cells from adult somatic cells for personalized treatment and thus overcomes not only the limited availability of human embryonic stem cells but also ethical concerns surrounding their use. Non-viral, non-integration, or non-DNA-mediated reprogramming technologies are being developed. Protocols for generating midbrain DA neurons are undergoing constant refinement. The iPS cell-derived DA neurons provide cellular models for investigating disease progression in vitro and for screening molecules of novel therapeutic potential and have beneficial effects on improving the behavior of parkinsonian animals. Further progress in the development of safer non-viral/non-biased reprogramming strategies and the subsequent generation of homogenous midbrain DA neurons shall pave the way for clinical trials. A combined approach of drugs, cell replacement, and gene therapy to stop disease progression and to improve treatment may soon be within our reach. PMID:22494990

  1. [Recent advance in research of benign adult familial myoclonus epilepsy (BAFME): is BAFME a progressive disorder?].

    PubMed

    Hitomi, Takefumi; Takahashi, Ryosuke; Ikeda, Akio

    2014-01-01

    Benign adult familial myoclonus epilepsy (BAFME) is an adult onset, autosomal dominant disease characterized by cortical tremor and infrequent generalized seizures. BAFME was considered as non-progressive, but cortical tremor worsened in some of the aged patients. We investigated the disease progression of BAFME. Cortical tremor significantly worsened and amplitudes of giant somatosensory evoked potential significantly increased with age in BAFME. These findings suggest that a progressive increase of cortical hyperexcitability causes exaggeration of cortical tremor. The clinical anticipation, defined as earlier onset age of either cortical tremor or generalized seizures or new appearance of those symptoms in the next generation, was observed in all studied BAFME families. In addition, a higher degree of clinical anticipation was associated with maternal transmission than with paternal transmission. Despite a unknown causative gene for BAFME, our finding suggests that BAFME and diseases with unstable expanding repeats including those in non-coding regions, might share a similar molecular mechanism because such diseases often show clinical anticipation with maternal transmission. As mentioned above, at least some part of the symptoms and pathophysiology progress with aging or over generation in BAFME. PMID:25672731

  2. Competency Progression and Completion: How Is the Policy Being Enacted in Three Trades? Research Report

    ERIC Educational Resources Information Center

    Clayton, Berwyn; Guthrie, Hugh; Every, Pam; Harding, Regan

    2015-01-01

    This paper examines how competency progression and completion is implemented in practice in three trades. In particular, it focuses on: interactions between teachers and/or assessors and workplace supervisors; the different approaches used to integrate on- and off-the job training; assessment and signoff practices; and the ways by which workplace…

  3. FY2013 Progress Report for Advanced Combustion Engine Research and Development

    SciTech Connect

    none,

    2013-12-01

    Annual progress report on the work of the the Advanced Combustion Engine Program. The Advanced Combustion Engine Program supports the Vehicle Technologies Office mission by addressing critical technical barriers to commercializing higher efficiency, very low emissions, advanced combustion engines for passenger and commercial vehicles that meet future federal emissions regulations.

  4. Chemistry research and development. Progress report, December 1978-May 1979. [Component, pilot plant, instrumentation

    SciTech Connect

    Miner, F. J.

    1980-06-30

    Progress and activities are reported on component development, pilot plant development, and instrumentation and statistical systems. Specific items studied include processing of pond sludge, transport of radioactive materials and wastes, corrosion, decontamination and cleaning, fluidized-bed incineration, Pu contamination of soils, chemical analysis, radiometric analysis, security. (DLC)

  5. Applied Nuclear Science Research and Development progress report, June 1, 1984-May 31, 1985

    SciTech Connect

    Arthur, E.D.; Mutschlecner, A.D.

    1985-09-01

    This progress report describes the activities of the Los Alamos Applied Nuclear Science Group for June 1, 1984 through May 31, 1985. The topical content includes the theory and evaluation of nuclear cross sections; neutron cross section processing and testing; neutron activation, fission products and actinides; and core neutronics code development and application. 70 refs., 31 figs., 15 tabs. (WRF)

  6. Applied nuclear data research and development. Semiannual progress report, April 1-September 30, 1983

    SciTech Connect

    Arthur, E.D.

    1984-06-01

    This progress report describes the activities of the Los Alamos Nuclear Data Group for April 1, 1983 through September 30, 1983. Topics covered include theory and evaluation of nuclear cross sections; nuclear cross-section processing and testing; neutron activation; fission products, and actinides; and core neutronics code development in support of LMFBR carbide core assessment. (GHT)

  7. Gas Bubble Trauma Monitoring and Research of Juvenile Salmonids, 1994-1995 Progress Report.

    SciTech Connect

    Hans, Karen M.

    1997-07-01

    This report describes laboratory and field monitoring studies of gas bubble trauma (GBT) in migrating juvenile salmonids in the Snake and Columbia rivers. The first chapter describes laboratory studies of the progression of GBT signs leading to mortality and the use of the signs for GBT assessment. The progression and severity of GBT signs in juvenile salmonids exposed to different levels of total dissolved gas (TDG) and temperatures was assessed and quantified. Next, the prevalence, severity, and individual variation of GBT signs was evaluated to attempt to relate them to mortality. Finally, methods for gill examination in fish exposed to high TDG were developed and evaluated. Primary findings were: (1) no single sign of GBT was clearly correlated with mortality, but many GBT signs progressively worsened; (2) both prevalence and severity of GBT signs in several tissues is necessary; (3) bubbles in the lateral line were the earliest sign of GBT, showed progressive worsening, and had low individual variation but may develop poorly during chronic exposures; (4) fin bubbles had high prevalence, progressively worsened, and may be a persistent sign of GBT; and (5) gill bubbles appear to be the proximate cause of death but may only be relevant at high TDG levels and are difficult to examine. Chapter Two describes monitoring results of juvenile salmonids for signs of GBT. Emigrating fish were collected and examined for bubbles in fins and lateral lines. Preliminary findings were: (1) few fish had signs of GBT, but prevalence and severity appeared to increase as fish migrated downstream; (2) there was no apparent correlation between GBT signs in the fins, lateral line, or gills; (3) prevalence and severity of GBT was suggestive of long-term, non-lethal exposure to relatively low level gas supersaturated water; and (4) it appeared that GBT was not a threat to migrating juvenile salmonids. 24 refs., 26 figs., 3 tabs.

  8. Advanced research and technology development fossil energy materials program. Quarterly progress report for the period ending September 30, 1981

    SciTech Connect

    Bradley, R.A.

    1981-12-01

    This is the fourth combined quarterly progress report for those projects that are part of the Advanced Research and Technology Development Fossil Energy Materials Program. The objective is to conduct a program of research and development on materials for fossil energy applications with a focus on the longer-term and generic needs of the various fossil fuel technologies. The program includes research aimed toward a better understanding of materials behavior in fossil energy environments and the development of new materials capable of substantial enhancement of plant operations and reliability. Work performed on the program generally falls into the Applied Research and Exploratory Development categories as defined in the DOE Technology Base Review, although basic research and engineering development are also conducted. A substantial portion of the work on the AR and TD Fossil Energy Materials Program is performed by participating cntractor organizations. All subcontractor work is monitored by Program staff members at ORNL and Argonne National Laboratory. This report is organized in accordance with a work breakdown structure defined in the AR and TD Fossil Energy Materials Program Plan for FY 1981 in which projects are organized according to fossil energy technologies. We hope this series of AR and TD Fossil Energy Materials Program quarterly progress reports will aid in the dissemination of information developed on the program.

  9. Progress and status of the IAEA coordinated research project: production of Mo-99 using LEU fission or neutron activation

    SciTech Connect

    Goldman, Ira N.; Adelfang, Pablo E-mail: P.Adelfang@iaea.org; Ramamoorthy, Natesan

    2008-07-15

    Since late 2004, the IAEA has developed and implemented a Coordinated Research Project (CRP) to assist countries interested in initiating indigenous, small-scale production of Mo-99 to meet local nuclear medicine requirements. The objective of the CRP is to provide interested countries with access to non-proprietary technologies and methods to produce Mo-99 using LEU foil or LEU mini-plate targets, or for the utilization of n,gamma neutron activation, e.g. through the use of gel generators. The project has made further progress since the RERTR 2006 meeting, with a Technical Workshop on Operational Aspects of Mo99 Production held 28-30 November 2006 in Vienna and the Second Research Coordination Meeting held in Bucharest, Romania 16-20 April 2007. The paper describes activities carried out as noted above, and as well as the provision of LEU foils to a number of participants, and the progress by a number of groups in preparing for LEU target assembly and disassembly, irradiation, chemical processing, and waste management. The participants' progress in particular on thermal hydraulics computations required for using LEU targets is notable, as also the progress in gel generator plant operations in India and Kazakhstan. Poland has joined as a new research agreement holder and an application by Egypt to be a contract holder is undergoing internal review in the IAEA and is expected to be approved. The IAEA has also participated in several open meetings of the U.S. National Academy of Sciences Study on Producing Medical Radioisotopes without HEU, which will also be discussed in the paper. (author)

  10. Materials Compatibility and Lubricants Research on CFC-refrigerant substitutes. Quarterly progress report, 1 July 1992--30 September 1992

    SciTech Connect

    Hourahan, G.C.; Szymurski, S.R.

    1992-10-01

    The Materials Compatibility and Lubricants Research (MCLR) program supports critical research to accelerate the introduction of CFC-refrigerant substitutes. The MCLR program addresses refrigerant and lubricant properties and materials compatibility. The primary elements of the work include data collection and dissemination, materials compatibility testing, and methods development. The work is guided by an Advisory Committee consisting of technical experts from the refrigeration and air-conditioning industry and government agencies. Under the current MCLR pregrain the Air-Conditioning and Refrigeration Technology Institute, Inc., (ARTI) is contracting and managing several research projects and a data collection and dissemination effort. Preliminary results is from these projects are reported in technical progress reports prepared by each researcher.

  11. Frederick W. Alt received the 2015 Szent-Györgi Prize for Progress in Cancer Research.

    PubMed

    Scully, Peter; Zhao, Jie; Ba, Sujuan

    2016-01-01

    The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award established by the National Foundation for Cancer Research (NFCR)-a leading cancer research charitable organization in the United States that is committed to supporting scientific research and public education relating to the prevention, early diagnosis, better treatments, and ultimately, a cure for cancer. Each year, the Szent-Györgyi Prize honors an outstanding researcher, nominated by colleagues or peers, who has contributed outstanding, significant research to the fight against cancer, and whose accomplishments have helped improve treatment options for cancer patients. The Prize also promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer treatments. This report highlights the pioneering work led by the 2015 Prize winner, Dr. Frederick Alt. Dr. Alt's work in the area of cancer genetics over four decades has helped to shape the very roots of modern cancer research. His work continues to profoundly impact the approaches that doctors around the globe use to diagnose and treat cancer. In particular, his seminal discoveries of gene amplification and his pioneering work on molecular mechanisms of DNA damage repair have helped to usher in the era of genetically targeted therapy and personalized medicine. PMID:26843073

  12. Progress and Prospect: A Bibliometric Analysis of Research Papers by Korean Allergists Over Recent Five Years (2009-2013)

    PubMed Central

    Song, Woo-Jung; Jee, Hye Mi; Suh, Dong In; Yang, Hyeon-Jong; Yoon, Jong-seo; Yu, Jinho; Kim, Sang-Heon; Ye, Young-Min; Kim, Tae-Bum; Shin, Seung Youp; Li, Kapsok

    2015-01-01

    Since the establishment of the academic society in 1972, Korean allergists have made continuous efforts to elucidate pathogenic mechanisms and therapeutic advances for allergic diseases. The present study aimed to summarize recent progress and explore future prospects of research performance by Korean allergists. We performed a comprehensive bibliometric analysis for research papers published in the Science Citation Index (SCI) or SCI-expanded journals by Korean allergists between 2009 and 2013. Research performance was quantitatively analyzed for the numbers of papers by publication year, research type, and main topic. In addition, the performance was also examined for qualitative indices, such as impact factor and citation number. A total of 1,091 papers were identified. The number of publication increased continuously, with an annual increase rate of 12.3%. Clinical and basic studies were the most frequent types of research, and recently the number of epidemiological studies has increased. By research topic, asthma was the most commonly studied, accounting for 20.9% of the total number of publications. Notably, the amount of rhinitis/rhinosinusitis research has risen steeply in 2013. Qualitative analyses also indicated continuous progress; the median impact factor of published journals increased from 1.918 in 2009 to 2.746 in 2013, yielding an annual increase rate of 7.4%. In conclusion, the present analyses identified a continuous increase in the research performance of Korean allergists over a recent 5 year period (2009-2013), both quantitatively and qualitatively. A more significant contribution is expected in the forthcoming era. PMID:26122510

  13. Progress and Prospect: A Bibliometric Analysis of Research Papers by Korean Allergists Over Recent Five Years (2009-2013).

    PubMed

    Song, Woo Jung; Jee, Hye Mi; Suh, Dong In; Yang, Hyeon Jong; Yoon, Jong Seo; Yu, Jinho; Kim, Sang Heon; Ye, Young Min; Kim, Tae Bum; Shin, Seung Youp; Li, Kapsok; Kim, Cheol Woo

    2015-09-01

    Since the establishment of the academic society in 1972, Korean allergists have made continuous efforts to elucidate pathogenic mechanisms and therapeutic advances for allergic diseases. The present study aimed to summarize recent progress and explore future prospects of research performance by Korean allergists. We performed a comprehensive bibliometric analysis for research papers published in the Science Citation Index (SCI) or SCI-expanded journals by Korean allergists between 2009 and 2013. Research performance was quantitatively analyzed for the numbers of papers by publication year, research type, and main topic. In addition, the performance was also examined for qualitative indices, such as impact factor and citation number. A total of 1,091 papers were identified. The number of publication increased continuously, with an annual increase rate of 12.3%. Clinical and basic studies were the most frequent types of research, and recently the number of epidemiological studies has increased. By research topic, asthma was the most commonly studied, accounting for 20.9% of the total number of publications. Notably, the amount of rhinitis/rhinosinusitis research has risen steeply in 2013. Qualitative analyses also indicated continuous progress; the median impact factor of published journals increased from 1.918 in 2009 to 2.746 in 2013, yielding an annual increase rate of 7.4%. In conclusion, the present analyses identified a continuous increase in the research performance of Korean allergists over a recent 5 year period (2009-2013), both quantitatively and qualitatively. A more significant contribution is expected in the forthcoming era. PMID:26122510

  14. Computation and graphics in mathematical research. Progress report, June 1, 1991--May 31, 1992

    SciTech Connect

    Hoffman, D.A.; Spruck, J.

    1992-08-13

    This report discusses: The description of the GANG Project and results for prior research; the center for geometry, analysis, numerics and graphics; description of GANG Laboratory; software development at GANG; and mathematical and scientific research activities.

  15. FY2009 Annual Progress Report for Energy Storage Research and Development

    SciTech Connect

    none,

    2010-01-19

    The energy storage research and development effort within the VT Program is responsible for researching and improving advanced batteries and ultracapacitors for a wide range of vehicle applications, including HEVs, PHEVs, EVs, and fuel cell vehicles (FCVs).

  16. Research in theoretical physics. Annual progress report, April 1, 1992--March 31, 1993

    SciTech Connect

    Domokos, G.; Kovesi-Domokos, S.

    1992-12-01

    Progress made in the following areas is summarized: simulation of extensive air showers induced by interactions existing beyond the currently accepted ``Standard Model`` of elementary particle interactions; search for physics beyond the ``Standard Model`` in gluonic inclusive decays of heavy quarks; obtaining limits on the applicability of the special theory of relativity; an improved method of obtaining upper limits on the masses of primaries of extensive air showers associated with point sources in the sky. 8 figs., 1 tab., 73 refs.

  17. [Treatment research progress on the treatment of neurofibromatosis type 2-associated vestibular schwannoma].

    PubMed

    Zhao, Yingchao; Yang, Qin; Jiang, Yao

    2015-05-01

    Neurofibromatosis type 2 (NF2) is a dominantly inherited genetic condition. Bilateral vestibular schwannoma, which are benign tumors, composed of neoplastic Schwann cells that arise from the eighth cranial nerve, are the hallmark of NF2. Standard approaches for treatment of growing vestibular schwannoma include observation, surgical removal and radiation therapy. Molecular targeted therapies also present great prosperity in recent years. In this review, we summarize the latest progresses on the treatment of NF2-associated vestibular schwannoma. PMID:26596021

  18. U.C. Davis high energy particle physics research: Technical progress report -- 1990

    SciTech Connect

    1990-12-31

    Summaries of progress made for this period is given for each of the following areas: (1) Task A--Experiment, H1 detector at DESY; (2) Task C--Experiment, AMY detector at KEK; (3) Task D--Experiment, fixed target detectors at Fermilab; (4) Task F--Experiment, PEP detector at SLAC and pixel detector; (5) Task B--Theory, particle physics; and (6) Task E--Theory, particle physics.

  19. Shale oil value enhancement research. First quarterly technical progress report, March 1, 1993--May 31, 1993

    SciTech Connect

    Bunger, J.W.; Russell, C.P.; Devineni, P.A.V.; Cogswell, D.E.; Wiser, J.W.

    1993-06-25

    Concurrent progress is being made in all key areas, namely, separation, characterization and market assessment. The market area, not one of our traditionally strong areas, has been going better than expected. We believe this is due mainly to the emerging interest in new and unconventional materials. The characterization work has been progressing solidly with the fundamental Z-BASIC correlations providing information not heretofore available in the chemical literature. Our agreement with Hewlett-Packard regarding the purchase of equipment at a reduced price is complete and the gc-ms will be ordered shortly. The separation work has progressed satisfactorily although an unexpected amount of time has been required for ``facilities`` and ``equipment`` related issues. Some of these issues have dealt with safety and regulatory compliance when storing larger quantities of samples. These now seem to be solved. We have a lot of direct experience in shale oil separations dating back to the OXY project and before. Also, we will streamline our work by going to prepacked micro-separation tools for some of our separation characterization work. This will allow us to stay on schedule. Overall, we are on schedule with the project. All administration requirements are in place and the accounting and financial records are current.

  20. Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility.

    PubMed

    Zaveri, Nurulain T

    2016-08-11

    In the two decades since the discovery of the nociceptin opioid receptor (NOP) and its ligand, nociceptin/orphaninFQ (N/OFQ), steady progress has been achieved in understanding the pharmacology of this fourth opioid receptor/peptide system, aided by genetic and pharmacologic approaches. This research spawned an explosion of small-molecule NOP receptor ligands from discovery programs in major pharmaceutical companies. NOP agonists have been investigated for their efficacy in preclinical models of anxiety, cough, substance abuse, pain (spinal and peripheral), and urinary incontinence, whereas NOP antagonists have been investigated for treatment of pain, depression, and motor symptoms in Parkinson's disease. Translation of preclinical findings into the clinic is guided by PET and receptor occupancy studies, particularly for NOP antagonists. Recent progress in preclinical NOP research suggests that NOP agonists may have clinical utility for pain treatment and substance abuse pharmacotherapy. This review discusses the progress toward validating the NOP-N/OFQ system as a therapeutic target. PMID:26878436

  1. Review of Physics Research Programs at LAMPF. Progress report, January-December 1983

    SciTech Connect

    Allred, J.C.

    1984-04-01

    Research and development summaries are presented under the main headings: research, proton storage ring construction and research program development, status of LAMPF II, facility and experimental development, and accelerator operations. Complete lists are given for experiments run in 1983, new prospects, and active and complete experiments by channel. (WHK)

  2. Progress on Establishing a World Education Research Association Continues at Third International Meeting

    ERIC Educational Resources Information Center

    Educational Researcher, 2008

    2008-01-01

    Representatives of 28 education research associations from around the world convened in New York on March 29-30, 2008 at a third meeting to advance the goal of establishing a world education research association (informally called "WERA"). The agenda centered on the nature and form of a world education research association, with discussions…

  3. University of Illinois at Urbana-Champaign, Materials Research Laboratory progress report for FY 1992

    SciTech Connect

    Not Available

    1992-07-01

    This interdisciplinary laboratory in the College of Engineering support research in areas of condensed matter physics, solid state chemistry, and materials science. These research programs are developed with the assistance of faculty, students, and research associates in the departments of Physics, Materials Science and Engineering, chemistry, Chemical Engineering, Electrical Engineering, Mechanical Engineering, and Nuclear Engineering.

  4. Declassification Productivity Research Center annual progress report {number_sign}8, September 26, 1996--September 25, 1997

    SciTech Connect

    1997-11-01

    This report describes the progress achieved by the Declassification Productivity Research Center (DPRC) during the second year of operations. This report is submitted in lieu of a fourth quarterly performance report as the Grant continues into its third year. The intent of this report is to address progress against the statement of work (SOW) of the Grant. Accordingly, its format follows that of the SOW, and describes the DPRC research activities this past year and the resulting products. The DPRC was established as an independent, world-class research capability and computer facility to support the DOE Declassification Productivity Initiative (DPI). The goal of DPI is to increase the flow of unrestricted government information to the public. To this end, the work involves both basic and applied research in the areas of (1) system-level declassification process analysis and modeling, (2) development of computer systems to automate declassification processes, including text analysis and interpretation, (3) coordination/integration of new technology among into the processes, and (4) development and promulgation of inter-operability and document transfer standards.

  5. James P. Allison received the 2014 Szent-Györgi Prize for Progress in Cancer Research

    PubMed Central

    Zhao, Jie; Scully, Peter; Ba, Sujuan

    2014-01-01

    The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award established by the National Foundation for Cancer Research (NFCR)—a leading cancer research charitable organization in the United States that is committed to supporting innovative cancer research on the global scale that aims to cure cancer. Each year, the Szent-Györgyi Prize honors an outstanding researcher whose original discoveries have expanded our understanding of cancer and resulted in notable advances in cancer prevention, diagnosis, or treatment. The prize also promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer treatments. This report highlights the history and mission of the Szent-Györgyi Prize, its role in promoting discovery-oriented cancer research, and the pioneering work led by the 2014 prize winner, Dr. James Allison. Dr. Allison's work in the area of cancer immunotherapy led to the successful development of immune checkpoint therapy, and the first drug approved by the United States Food and Drug Administration for the treatment of metastatic melanoma. PMID:25189714

  6. Recent progress in research pertaining to estimates of gas-side heat transfer in an aircraft gas turbine

    NASA Technical Reports Server (NTRS)

    Graham, Robert W.

    1989-01-01

    A decade ago several important fundamental heat transfer phenomena were identified which were considered basic to the ability to predict heat transfer loads in aircraft gas turbines. The progress in addressing these fundamentals over the past ten years is assessed. Much reseach effort has been devoted to their study in university, industry and government labs and significant progress has been achieved. Advances in computer technology have enabled the modeling of complex 3-D fluid flow in gas turbines so necessary for heat transfer calculations. Advances in instrumentation plus improved data acquisition have brought about more reliable data sets. While much has advanced in the 1980's, much challenging research remains to be done. Several of these areas are suggested.

  7. Transactivation of Epidermal Growth Factor Receptor by G Protein-Coupled Receptors: Recent Progress, Challenges and Future Research

    PubMed Central

    Wang, Zhixiang

    2016-01-01

    Both G protein-coupled receptors (GPCRs) and receptor-tyrosine kinases (RTKs) regulate large signaling networks, control multiple cell functions and are implicated in many diseases including various cancers. Both of them are also the top therapeutic targets for disease treatment. The discovery of the cross-talk between GPCRs and RTKs connects these two vast signaling networks and complicates the already complicated signaling networks that regulate cell signaling and function. In this review, we focus on the transactivation of epidermal growth factor receptor (EGFR), a subfamily of RTKs, by GPCRs. Since the first report of EGFR transactivation by GPCR, significant progress has been made including the elucidation of the mechanisms underlying the transactivation. Here, we first provide a basic picture for GPCR, EGFR and EGFR transactivation by GPCR. We then discuss the progress made in the last five years and finally provided our view of the future challenge and future researches needed to overcome these challenges. PMID:26771606

  8. Consolidation in an Individual Transferable Quota Regime: Lessons from New Zealand, 1986-1999

    NASA Astrophysics Data System (ADS)

    Yandle, Tracy; Dewees, Christopher M.

    2008-06-01

    Market-based approaches to environmental regulation (such as tradable permits or transferable quotas) are frequently offered as innovative solutions to many environmental problems. Globally, one of the most well-established forms of this approach is individual transferable quotas (or ITQs) in fisheries management. Within the natural resource management community, there is considerable debate over the effects ITQs have on the fishing industry and fisher behavior although this approach is not well-established in the United States. The previously imposed moratorium on ITQs in the United States has expired and the 2006 reauthorization of the Magnuson-Stevens Act explicitly provides for limited access privileges (LAPs). A variety of fishers, regulators, and conservation organizations are enthusiastically seeking to introduce ITQ management. With debate over whether and how ITQs should be used in American fisheries reinvigorated, it is timely to examine the evidence on the social and economic effects of ITQs in other nations’ fisheries. After briefly summarizing the debate on ITQs, we examine the case of New Zealand, one of the earliest and longest-lived ITQ-based fisheries regimes. We use multiple data sources and methods to analyze the extent to which industry consolidation and aggregation has occurred, including surveys of industry participants, expert interviews, reviews of academic reports and analyses, analysis of trade publications, and direct analysis of quota ownership patterns. This analysis shows a more complex outcome than recent debates in the ITQ literature would predict. These findings suggest that policy makers considering ITQs can learn from the experiences of other countries related to key issues such as quota allocation, aggregation limits, transferability, cost recovery, and resource sustainability when designing ITQ and other LAP systems. It is also important to explicitly identify economic and social objectives and then carefully design ITQ regimes to meet these objectives.

  9. How to integrate biological research into society and exclude errors in biomedical publications? Progress in theoretical and systems biology releases pressure on experimental research

    PubMed Central

    Volkov, Vadim

    2014-01-01

    This brief opinion proposes measures to increase efficiency and exclude errors in biomedical research under the existing dynamic situation. Rapid changes in biology began with the description of the three dimensional structure of DNA 60 years ago; today biology has progressed by interacting with computer science and nanoscience together with the introduction of robotic stations for the acquisition of large-scale arrays of data. These changes have had an increasing influence on the entire research and scientific community. Future advance demands short-term measures to ensure error-proof and efficient development. They can include the fast publishing of negative results, publishing detailed methodical papers and excluding a strict connection between career progression and publication activity, especially for younger researchers. Further development of theoretical and systems biology together with the use of multiple experimental methods for biological experiments could also be helpful in the context of years and decades. With regards to the links between science and society, it is reasonable to compare both these systems, to find and describe specific features for biology and to integrate it into the existing stream of social life and financial fluxes. It will increase the level of scientific research and have mutual positive effects for both biology and society. Several examples are given for further discussion. PMID:24748913

  10. University of Illinois at Urbana-Champaign, Materials Research Laboratory progress report for FY 1991

    SciTech Connect

    Not Available

    1991-10-01

    The Materials Research Laboratory at the University of Illinois is an interdisciplinary laboratory operated in the College of Engineering. Its focus is the science of materials and it supports research in the areas of condensed matter physics, solid state chemistry, and materials science. This report addresses topics such as: an MRL overview; budget; general programmatic and institutional issues; new programs; research summaries for metallurgy, ceramics, solid state physics, and materials chemistry.

  11. The Preclinical Research Progress of Stem Cells Therapy in Parkinson's Disease.

    PubMed

    Zhang, Jun; Wang, Xianyun; Li, Jing; Huang, Rui; Yu, Xuerui; Dong, Ci; Liu, Pujuan; Zhang, Fan; Hu, Jie; Qi, Yixin; Zhang, Jing; Li, Quanhai; Yan, Baoyong

    2016-01-01

    Parkinson's disease (PD) is a type of degenerative disorder of the basal ganglia, causing tremor at rest, muscle rigidity hypokinesia, and dementia. The effectiveness of drug treatments gradually diminishes because the conversion to dopamine within the brain is increasingly disrupted by the progressive degeneration of the dopaminergic terminals. After long-term treatment, most patients with PD suffer from disability that cannot be satisfactorily controlled. To solve these issues, stem cells have recently been used for cell therapy of PD. In this review, the characteristics of different stem cells and their therapeutic effects on PD treatment will be discussed. PMID:27379248

  12. Progress of research on plasma facing materials in University of Science and Technology Beijing

    NASA Astrophysics Data System (ADS)

    Ge, Chang-Chun; Zhou, Zhang-Jian; Song, Shu-Xiang; Du, Juan; Zhong, Zhi-Hong

    2007-06-01

    In this paper, we report some new progress on plasma facing materials in University of Science and Technology Beijing (USTB), China. They include fabrication of tungsten coating with ultra-fine grain size by atmosphere plasma spraying; fabrication of tungsten with ultra-fine grain size by a newly developed method named as resistance sintering under ultra-high pressure; using the concept of functionally graded materials to join tungsten to copper based heat sink; joining silicon doped carbon to copper by brazing using a Ti based amorphous filler and direct casting.

  13. The research progress on Hodograph Method of aerodynamic design at Tsinghua University

    NASA Technical Reports Server (NTRS)

    Chen, Zuoyi; Guo, Jingrong

    1991-01-01

    Progress in the use of the Hodograph method of aerodynamic design is discussed. It was found that there are some restricted conditions in the application of Hodograph design to transonic turbine and compressor cascades. The Hodograph method is suitable not only to the transonic turbine cascade but also to the transonic compressor cascade. The three dimensional Hodograph method will be developed after obtaining the basic equation for the three dimensional Hodograph method. As an example of the Hodograph method, the use of the method to design a transonic turbine and compressor cascade is discussed.

  14. [The research progress of relationship between the obstructive sleep apnea hypopnea syndrome and asthma].

    PubMed

    Wang, Jinfeng; Xie, Yuping; Ma, Wei

    2015-02-01

    Obstructive sleep apnea hypopnea syndrome (OSAHS) is characterized by repeated episodes of upper airway obstruction that results in brief periods of breathing cessation (apnea) or a marked reduction in airflow (hypopnea) during sleep. Asthma is a chronic inflammatory disease of the airways characterized by revesible air-flow obstruction and bronchial hyperresponsiveness. This article reviewed related reseaches progress of relationship between the obstructive sleep apnea hypopnea syndrom and asthma in the vascular endothelial growth factor, systemic inflammation, leptin, obesity, gastroesophageal reflux disease and upper airway diseases, excessive daytime sleepiness and asthma control. PMID:26121849

  15. The Preclinical Research Progress of Stem Cells Therapy in Parkinson's Disease

    PubMed Central

    Wang, Xianyun; Li, Jing; Huang, Rui; Yu, Xuerui; Dong, Ci; Liu, Pujuan; Zhang, Fan; Hu, Jie; Qi, Yixin; Zhang, Jing

    2016-01-01

    Parkinson's disease (PD) is a type of degenerative disorder of the basal ganglia, causing tremor at rest, muscle rigidity hypokinesia, and dementia. The effectiveness of drug treatments gradually diminishes because the conversion to dopamine within the brain is increasingly disrupted by the progressive degeneration of the dopaminergic terminals. After long-term treatment, most patients with PD suffer from disability that cannot be satisfactorily controlled. To solve these issues, stem cells have recently been used for cell therapy of PD. In this review, the characteristics of different stem cells and their therapeutic effects on PD treatment will be discussed. PMID:27379248

  16. Research program in particle physics. Progress report, January 1, 1993--December 1993

    SciTech Connect

    Sudarshan, E.C.G.; Dicus, D.A.; Ritchie, J.L.; Lang, K.

    1993-05-01

    This report is the progress report for DOE funded support of particle physics work at the University of Texas, Austin. Support was divided between theoretical and experimental programs, and each is reviewed separately in the report. Theoretical effort was divided between three general areas: quantum gravity and mathematical physics; phenomenology; and quantum mechanics and quantum field theory. Experimental effort was primarily directed toward AGS experiments at Brookhaven, to look for rare kaon decays. AGS experiments 791 and 871 are described, along with BNL experiment 888.

  17. Decontamination Systems Information and Research Program. Quarterly technical progress report, July 1--September 30, 1993

    SciTech Connect

    Not Available

    1993-10-01

    Progress reports are presented for the following projects: systematic assessment of the state of hazardous waste clean-up technologies; site remediation technologies--drain-enhanced soil flushing (DESF) for organic contaminants removal; excavation systems for hazardous waste sites; chemical destruction of polychlorinated biphenyls; development of organic sensors--monolayer and multilayer self-assembled films for chemical sensors; Winfield Lock and Dam remediation; Winfield cleanup survey; assessment of technologies for hazardous waste site remediation--non-treatment technologies and pilot scale test facility implementation; assessment of environmental remediation storage technology; assessment of environmental remediation excavation technology; assessment of environmental remediation monitoring technology; and remediation of hazardous sites with steam reforming.

  18. Decontamination Systems Information and Research Program. Quarterly technical progress report, January 1--March 31, 1993

    SciTech Connect

    Not Available

    1993-04-01

    This reports reports the progress/efforts performed on six technical projects: 1. systematic assessment of the state of hazardous waste clean-up technologies; 2. site remediation technologies (SRT):drain- enhanced soil flushing for organic contaminants removal; 3. SRT: in situ bio-remediation of organic contaminants; 4. excavation systems for hazardous waste sites: dust control methods for in-situ nuclear waste handling; 5. chemical destruction of polychlorinated biphenyls; and 6. development of organic sensors: monolayer and multilayer self-assembled films for chemical sensors.

  19. Energy-conserving technologies for industry: a summary of recent progress in research and development

    SciTech Connect

    Monarch, M.; Alston, T.; Macal, K.; Macal, C.; Tatar, J.; Hersh, H.; Blomquist, C.; Singh, M.; Larsen, R.

    1984-01-01

    Fifty-six summary sheets on energy-conserving industrial technologies were prepared. These summaries describe Office of Industrial Programs (OIP) energy-conservation and waste-recovery projects that have progressed to the point of potential industrial application. Possibilities for cross-industry applications are pointed out in many of the summary sheets. Each summary includes the following types of information: industrial application, process energy savings, conventional situation, new technology, R and D project development and status, technical information, economic analysis, and industry-wide savings.

  20. Exploratory energy research program of the University of Hawaii at Manoa. Progress report

    SciTech Connect

    Not Available

    1984-01-01

    Progress is reported from the University of Hawaii on: UHM rooftop solar energy laboratory; solar pond cleansing techniques; combustion properties of biomass pyrolysis products; high-temperature solar concentrator absorber; biological abatement of hydrogen sulfide during geothermal energy production; geothermal systems on submarine rift zones of the Hawaiian chain; nitrogenous products of OTEC chlorination; interaction of hydrogen and deuterium with transition metals and their alloys at high pressures; shallow magma chambers and geothermal potential of Haleakala, Maui; effects of OTEC waste water on phytoplankton; sodium-lithium geothermometer; breaking wave forces on OTEC pipes; seismic and thermal properties on basalts. (PSB)

  1. Research in elementary particle physics. Progress report, March 1, 1992--February 28, 1993

    SciTech Connect

    Chan, Lai-Him; Haymaker, R.; Imlay, R.; McNeil, R.; Metcalf, W.; Svoboda, R.

    1992-10-01

    We describe theoretical work on effective action expansion on an effective low energy theory of hadrons and lattice gauge theories. The high energy experimental group at Louisiana State University has analyzed data on a neutrino oscillation experiment at LAMPF. The LSND neutrino experiment is preparing to take data in 1993. IMB data has been analyzed. Preparations for a beam test at KEK for IMB are in progress. Dumand is preparing to test one string of the detector early next summer. The ZEUS electron proton colliding beam experiment has started to take data. Early results have been reported.

  2. Research in progress and other activities of the Institute for Computer Applications in Science and Engineering

    NASA Technical Reports Server (NTRS)

    1993-01-01

    This report summarizes research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics and computer science during the period April 1, 1993 through September 30, 1993. The major categories of the current ICASE research program are: (1) applied and numerical mathematics, including numerical analysis and algorithm development; (2) theoretical and computational research in fluid mechanics in selected areas of interest to LaRC, including acoustic and combustion; (3) experimental research in transition and turbulence and aerodynamics involving LaRC facilities and scientists; and (4) computer science.

  3. Research in progress in applied mathematics, numerical analysis, fluid mechanics, and computer science

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This report summarizes research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, fluid mechanics, and computer science during the period October 1, 1993 through March 31, 1994. The major categories of the current ICASE research program are: (1) applied and numerical mathematics, including numerical analysis and algorithm development; (2) theoretical and computational research in fluid mechanics in selected areas of interest to LaRC, including acoustics and combustion; (3) experimental research in transition and turbulence and aerodynamics involving LaRC facilities and scientists; and (4) computer science.

  4. Chemistry {ampersand} Materials Science progress report summary of selected research and development topics, FY97

    SciTech Connect

    Newkirk, L.

    1997-12-01

    This report contains summaries of research performed in the Chemistry and Materials Science division. Topics include Metals and Ceramics, High Explosives, Organic Synthesis, Instrument Development, and other topics.

  5. Western Research Institute: Annual technical progress report, October 1986--September 1987

    SciTech Connect

    Not Available

    1987-10-01

    Accomplishments for the year are presented for the following five areas of research: oil shale, tar sand, underground coal gasification, advanced process technology, and advanced fuel research. Oil shale research covers: chemical and physical characterization of reference shales; oil shale retorting studies; and environmental base studies for oil shale. Tar sand covers: reference resource (tar sand deposits) evaluation; chemical and physical propeerties of reference tar sand; recovery processes; mathematical modeling; product evaluation; and environmental base studies. Underground coal gasification covers environmental impact assessment and groundwater impact mitigation. Advanced process technology includes advanced process analysis (contaminant control and new technology) and advanced mitigation concepts. Advanced fuels research is on jet fuels from coal. (AT).

  6. Computation and graphics in mathematical research. Progress report, September 15, 1992--September 15, 1993

    SciTech Connect

    Hoffman, D.A.; Spruck, J.

    1993-06-01

    Current research is described on: grain boundaries and dislocations in compound polymers, boundary value problems for hypersurfaces constant Gaussian curvature, and discrete computational geometry. 19 refs, 4 figs.

  7. Progress in human embryonic stem cell research in the United States between 2001 and 2010.

    PubMed

    Vakili, Keyvan; McGahan, Anita M; Rezaie, Rahim; Mitchell, Will; Daar, Abdallah S

    2015-01-01

    On August 9th, 2001, the federal government of the United States announced a policy restricting federal funds available for research on human embryonic stem cell (hESCs) out of concern for the "vast ethical mine fields" associated with the creation of embryos for research purposes. Until the policy was repealed on March 9th, 2009, no U.S. federal funds were available for research on hESCs extracted after August 9, 2001, and only limited federal funds were available for research on a subset of hESC lines that had previously been extracted. This paper analyzes how the 2001 U.S. federal funding restrictions influenced the quantity and geography of peer-reviewed journal publications on hESC. The primary finding is that the 2001 policy did not have a significant aggregate effect on hESC research in the U.S. After a brief lag in early 2000s, U.S. hESC research maintained pace with other areas of stem cell and genetic research. The policy had several other consequences. First, it was tied to increased hESC research funding within the U.S. at the state level, leading to concentration of related activities in a relatively small number of states. Second, it stimulated increased collaborative research between US-based scientists and those in countries with flexible policies toward hESC research (including Canada, the U.K., Israel, China, Spain, and South Korea). Third, it encouraged independent hESC research in countries without restrictions. PMID:25812114

  8. The impact of regulations, safety considerations and physical limitations on research progress at maximum biocontainment.

    PubMed

    Shurtleff, Amy C; Garza, Nicole; Lackemeyer, Matthew; Carrion, Ricardo; Griffiths, Anthony; Patterson, Jean; Edwin, Samuel S; Bavari, Sina

    2012-12-01

    We describe herein, limitations on research at biosafety level 4 (BSL-4) containment laboratories, with regard to biosecurity regulations, safety considerations, research space limitations, and physical constraints in executing experimental procedures. These limitations can severely impact the number of collaborations and size of research projects investigating microbial pathogens of biodefense concern. Acquisition, use, storage, and transfer of biological select agents and toxins (BSAT) are highly regulated due to their potential to pose a severe threat to public health and safety. All federal, state, city, and local regulations must be followed to obtain and maintain registration for the institution to conduct research involving BSAT. These include initial screening and continuous monitoring of personnel, controlled access to containment laboratories, accurate and current BSAT inventory records. Safety considerations are paramount in BSL-4 containment laboratories while considering the types of research tools, workflow and time required for conducting both in vivo and in vitro experiments in limited space. Required use of a positive-pressure encapsulating suit imposes tremendous physical limitations on the researcher. Successful mitigation of these constraints requires additional time, effort, good communication, and creative solutions. Test and evaluation of novel vaccines and therapeutics conducted under good laboratory practice (GLP) conditions for FDA approval are prioritized and frequently share the same physical space with important ongoing basic research studies. The possibilities and limitations of biomedical research involving microbial pathogens of biodefense concern in BSL-4 containment laboratories are explored in this review. PMID:23342380

  9. Nondestructive Evaluation (NDE) Research Progress in 1988, Proceedings From the Ninth Annual EPRI NDE Information Meeting

    SciTech Connect

    1989-05-01

    Nondestructive evaluation (NDE) research has led to improved technologies and new procedures for inspecting electric generating plant components. This review of 1988 EPRI research discusses NDE procedures for pressure vessel and containment weld examinations, assessments of the eddy-current technology for steam generators, and integrated ultrasonic techniques for examining cast austenitic stainless components.

  10. Research in progress in applied mathematics, numerical analysis, and computer science

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Research conducted at the Institute in Science and Engineering in applied mathematics, numerical analysis, and computer science is summarized. The Institute conducts unclassified basic research in applied mathematics in order to extend and improve problem solving capabilities in science and engineering, particularly in aeronautics and space.

  11. Recycling research progress at the forest products laboratory. Forest Service general technical report

    SciTech Connect

    1995-09-01

    This document summarizes accomplishments of USDA Forest Service researchers in the area of recycling. Specifically, it describes work in economic assessment paper recycling, recycled housing and industrial applications of recycle materials, other recycled applications, and technology transfer. The literature list includes the references cited in the text and additional publications regarding Forest Service recycling research.

  12. The Impact of Regulations, Safety Considerations and Physical Limitations on Research Progress at Maximum Biocontainment

    PubMed Central

    Shurtleff, Amy C.; Garza, Nicole; Lackemeyer, Matthew; Carrion, Ricardo; Griffiths, Anthony; Patterson, Jean; Edwin, Samuel S.; Bavari, Sina

    2012-01-01

    We describe herein, limitations on research at biosafety level 4 (BSL-4) containment laboratories, with regard to biosecurity regulations, safety considerations, research space limitations, and physical constraints in executing experimental procedures. These limitations can severely impact the number of collaborations and size of research projects investigating microbial pathogens of biodefense concern. Acquisition, use, storage, and transfer of biological select agents and toxins (BSAT) are highly regulated due to their potential to pose a severe threat to public health and safety. All federal, state, city, and local regulations must be followed to obtain and maintain registration for the institution to conduct research involving BSAT. These include initial screening and continuous monitoring of personnel, controlled access to containment laboratories, accurate and current BSAT inventory records. Safety considerations are paramount in BSL-4 containment laboratories while considering the types of research tools, workflow and time required for conducting both in vivo and in vitro experiments in limited space. Required use of a positive-pressure encapsulating suit imposes tremendous physical limitations on the researcher. Successful mitigation of these constraints requires additional time, effort, good communication, and creative solutions. Test and evaluation of novel vaccines and therapeutics conducted under good laboratory practice (GLP) conditions for FDA approval are prioritized and frequently share the same physical space with important ongoing basic research studies. The possibilities and limitations of biomedical research involving microbial pathogens of biodefense concern in BSL-4 containment laboratories are explored in this review. PMID:23342380

  13. Systematic Review of Design-Based Research Progress: Is a Little Knowledge a Dangerous Thing?

    ERIC Educational Resources Information Center

    McKenney, Susan; Reeves, Thomas C.

    2013-01-01

    Sufficient attention and resources have been allocated to design-based research (DBR) to warrant review concerning if and how its potential has been realized. Because the DBR literature clearly indicates that this type of research strives toward both the development of an intervention to address a problem in practice and empirical investigation…

  14. Assigning Inquiry: How Handouts for Research Assignments Guide Today's College Students. Project Information Literacy Progress Report

    ERIC Educational Resources Information Center

    Head, Alison J.; Eisenberg, Michael B.

    2010-01-01

    A report of findings from a content analysis of 191 course-related research assignment handouts distributed to undergraduates on 28 college campuses across the U.S., as part of Project Information Literacy. A majority of handouts in the sample emphasized standards about the mechanics of compiling college research papers, more so than guiding…

  15. Research on Screening and Diagnosis in Autism: A Work in Progress.

    ERIC Educational Resources Information Center

    Bristol-Power, Marie M.; Spinella, Giovanna

    1999-01-01

    This article summarizes results of a 1998 conference which reviewed research on screening and diagnosis of autism spectrum disorders and identifies promising areas of research especially the search for the ultimate diagnostic indicator, infant screening and diagnosis, the role of sensory-motor disorders, diagnosis of co-occurring disorders,…

  16. National Institute for Petroleum and Energy Research monthly progress report for December 1990

    SciTech Connect

    Not Available

    1991-01-22

    Research programs from the National Institute for Petroleum and Energy Research (NIPER) are briefly described. Topics include enhanced recovery, studies on reservoir rock, microbial EOR, development of analytical techniques for petroleum analysis, and imaging techniques applied to fluids study in porous media. (CBS)

  17. Medical Education and Research Costs (MERC). Study Recommendations and Progress Report to the Legislature.

    ERIC Educational Resources Information Center

    Minnesota State Dept. of Health, St. Paul.

    This report discusses the activities of Minnesota's Medical Education and Research Costs (MERC) project, which was undertaken to gather data on the costs of medical education and health care research conducted by hospitals, medical centers, and health maintenance organizations and to develop mechanisms to assess the costs across the health care…

  18. Advanced Research and Technology Development Fossil Energy Materials Program. Quarterly progress report for the period ending September 30, 1983

    SciTech Connect

    Not Available

    1983-11-01

    The objective of the AR and TD Fossil Energy Materials Program is to conduct research and development on materials for fossil energy applications with a focus on the longer-term and generic needs of the various fossil fuel technologies. The program includes research aimed toward a better understanding of materials behavior in fossil energy environments and the development of new materials capable of substantial enhancement of plant operations and reliability. The management of the Program has been decentralized to DOE Oak Ridge Operations Office (ORO) and the Oak Ridge National Laboratory (ORNL) as technical support contractor. The ORNL Fossil Energy Materials Program Office compiles and issues this combined quarterly progress report from camera-ready copies submitted by each of the participating subcontractor organizations. This report of activities on the program is organized in accordance with a work breakdown structure defined in the AR and TD Fossil Energy Materials Program Plan for FYs 1982 to 1986 in which projects are organized according to fossil energy technologies. It is the intent of the AR and TD Fossil Energy Materials Program to sponsor materials research which is generic to a number of fossil energy technologies. We hope this series of AR and TD Fossil Energy Materials Program quarterly progress reports will aid in the dissemination of information developed on the program.

  19. The Radiological Research Accelerator Facility. Progress report, December 1, 1992--November 30, 1993

    SciTech Connect

    Hall, E.J.; Marino, S.A.

    1993-05-01

    The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generate a variety of well-characterized radiation beams for research in radiobiology, radiological physics, and radiation chemistry. It is part of the Center for Radiological Research (CRR) - formerly the Radiological Research Laboratory of Columbia University, and its operation is supported as a National Facility by the US Department of Energy (DOE). As such, RARAF is available to all potential users on an equal basis and scientists outside the CRR are encouraged to submit proposals for experiments at RARAF. The operation of the Van de Graaff is supported by the DOE, but the research projects themselves must be supported separately. This report provides a listing and brief description of experiments performed at RARAF during the May 1, 1992 through April 30, 1993.

  20. Matchmaking, metrics and money: a pathway to progress in translational research.

    PubMed

    Krontiris, Theodore G; Rubenson, David

    2008-10-01

    In the 24 years since the founding of BioEssays, the level of translational research, as well as the expectations for its success, have burgeoned. Based on our analysis of current and projected US efforts to establish effective centers of translational research, our own institutional experience and discussions with academic research center leaders and institutional research executives, we have arrived at several critical conclusions about how best to foster disease-based research on the institutional, national and international level, what summary statistics may best serve as a measurement of successful practice, roughly how much more money will be required to fund the ongoing venture in the US and how to organize and promote this vision. PMID:18800381

  1. Progress in X-ray Microcalorimeter Research for Solar Physics at LMSAL

    NASA Astrophysics Data System (ADS)

    Stern, R. A.; Deiker, S.; Martinez-Galarce, D.; Rausch, A.; Shing, L.; Boerner, P.; Cabrera, B.; Leman, S.; Brink, P.; Chakraborty, S.; Irwin, K.; Barbee, T. W., II

    2005-05-01

    LMSAL has begun a laboratory research program to develop TES (Transition Edge Sensor) microcalorimeter arrays for use in solar physics. We are currently testing TES arrays supplied by NIST. In addition, we have recently been funded under NASA's Solar and Heliospheric Research Program to begin work with NIST on position-sensitive X-ray strip detectors for solar physics applications. We are also collaborating with Stanford, LLNL, and NIST on a solar sounding rocket to perform soft X-ray imaging spectroscopy. In this poster, we will discuss the current status of this research and its applicability to future Explorers and Roadmap missions in the Sun-Solar System Connection research area. This work was supported in part by the Lockheed Martin Independent Research Program.

  2. A Review on Bioactivities of Perilla: Progress in Research on the Functions of Perilla as Medicine and Food

    PubMed Central

    2013-01-01

    Perilla is a useful pharmaceutical and food product and is empirically consumed by humans. However, its properties have not been evaluated extensively. In this review, we summarize the progress made in research, focusing on the bioactivities of perilla. There are many in vitro and animal studies on the cytostatic activity and antiallergic effects, respectively, of perilla and its constituents. However, its influence on humans remains unclear. Hence, investigating and clarifying the physiological effects of perilla and its constituents on humans are imperative in the future to adhere to the ideals of evidence-based medicine. PMID:24319488

  3. Research project on CO{sub 2}-induced climate change. Annual progress report, March 1, 1994--February 28, 1995

    SciTech Connect

    Cess, R.D.; Hameed, S.

    1995-01-01

    This summarizes current progress in the research project at SUNY Stony Brook on CO2-induced climate change. Three tasks are described, corresponding to the task categories in the USDOE/PRC CAS cooperative project on climate change. Task 1, led by Dr. Robert Cess, concerns the intercomparison of CO2 related climatic warming in contemporary general circulation models. Task 2, directed by Dr. Sultan Hameed, looks at understanding the natural variability in climatic data and comparing its significant features between observations and model simulations. Task 3, also directed by Dr. Hameed focuses on analysis of historical climate data developed at the institute of Geography of the Chinese Academy of Sciences.

  4. Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research

    PubMed Central

    Gonzalez, Liara M.; Moeser, Adam J.

    2014-01-01

    Research in the field of ischemia-reperfusion injury continues to be plagued by the inability to translate research findings to clinically useful therapies. This may in part relate to the complexity of disease processes that result in intestinal ischemia but may also result from inappropriate research model selection. Research animal models have been integral to the study of ischemia-reperfusion-induced intestinal injury. However, the clinical conditions that compromise intestinal blood flow in clinical patients ranges widely from primary intestinal disease to processes secondary to distant organ failure and generalized systemic disease. Thus models that closely resemble human pathology in clinical conditions as disparate as volvulus, shock, and necrotizing enterocolitis are likely to give the greatest opportunity to understand mechanisms of ischemia that may ultimately translate to patient care. Furthermore, conditions that result in varying levels of ischemia may be further complicated by the reperfusion of blood to tissues that, in some cases, further exacerbates injury. This review assesses animal models of ischemia-reperfusion injury as well as the knowledge that has been derived from each to aid selection of appropriate research models. In addition, a discussion of the future of intestinal ischemia-reperfusion research is provided to place some context on the areas likely to provide the greatest benefit from continued research of ischemia-reperfusion injury. PMID:25414098

  5. 2001 Gordon Research Conference on Organometallic Chemistry. Final progress report [agenda and attendee list

    SciTech Connect

    Burns, Carol

    2001-07-27

    The Gordon Research Conference on Organometallic Chemistry was held at Salve Regina University, Newport, Rhode Island, July 22-27, 2001. The conference had 133 participants. The attendees represented the spectrum of endeavor in this field, coming from academia, industry, and government laboratories, and included US and foreign scientists, senior researchers, young investigators, and students. Emphasis was place on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions; poster sessions were held.

  6. Biomedical research with cyclotron produced radionuclides. Progress report, February 1, 1981-December 31, 1981

    SciTech Connect

    Laughlin, J.S.

    1981-09-01

    Progress is reported in the following areas: evaluation of chemotherapeutic regimens in solid tumors using /sup 13/N-labelled amino acids; organ imaging with /sup 13/N-labelled L-amino acids; imaging with /sup 111/In-labelled-autologous platelets; synthesis and biological studies of /sup 111/In-labelled ammonia and L-amino acids; synthesis and evaluation for pancreatic imaging of /sup 11/C-labelled amino acides; radioisotope monitoring of myocardiol function; synthesis of /sup 11/C-labelled precursor compounds; reduction of radiation exposure through automation and remote control; development of an anhydrous /sup 18/F target; evaluation of radiolabelled 5-fluorouracils for scintigraphy; and methods of data analysis, modeling, and unproving instrumentation for positron-emission tomography. (EDB)

  7. (Research in the theory of condensed matter and elementary particles. ) Progress report

    SciTech Connect

    Not Available

    1986-01-01

    Progress is summarized in these areas: a new formulation of two dimensional critical phenomena and string theory, supersymmetric critical phenomena and string compactification, conformal field theory on orbifolds, Gaussian models with twisted boundary conditions, modular invariance and supersymmetric critical phenomena, critical indices, conformal invariance, and current algebra, renormalization group fixed points and the string equation of motion, fermionic string field theory, N = 2 super Riemann surfaces, the spinor field in covariant superstring theory, covariant quantization of superstrings, models of aggregation, and quasi-supersymmetry in the BCS mechanism. Further work is proposed in the areas of two dimensional critical phenomena, two dimensional conformal field theory and string theory, the physics of computation, models of aggregation, and the many vortex Aharonov-Bohm problem. 57 refs. (LEW)

  8. [Research progress in the study of protective effect of tanshinone IIA on cerebral ischemic stroke].

    PubMed

    Li, De-chuan; Bao, Xiu-qi; Sun, Hua; Zhang, Dan

    2015-06-01

    Danshen is one of the traditional Chinese herbal medicines and nas a long history or being used clinically in the treatment of cardiovascular and cerebrovascular conditions such as coronary heart disease and angina pectoris. Tanshinone IIA is a derivative of phenanthrene-quinone isolated from Danshen. It has been reported to be the major bioactive compound of Danshen and has diverse biological effects. Recent studies demonstrated that tanshinone IIA had neuroprotective effects on experimental ischemic stroke through its antiinflammatory, anti-oxidant, anti-apoptosis effects and its inhibitory effect on excitatory amino acid toxicity. In this review, we summarized all the recent progresses on the protective effect of tanshinone IIA on cerebral ischemic stroke. Hopefully, this article will throw some light on further study and application of tanshinone IIA. PMID:26521431

  9. Base program on energy related research. Quarterly technical progress report, August--October 1993

    SciTech Connect

    Not Available

    1993-12-31

    Progress reports are presented for the following area of studies: oil and gas; advanced systems applications; environmental technologies; and applied energy science. Oil and gas includes the following tasks: CROW{sup TM} process modeling; and miscible-immiscible gas injection processes. Advanced systems applications covers: development and optimization of a process for the production of a premium solid fuel from Western U.S. coals; development of an on-line alkali monitoring probe; optimization of the recycle oil process for Eastern oil shale; and process support and development. Tasks in the environmental technologies are: solid waste management; and remediation of contaminated soils. Applied energy science covers heavy oil/plastics co-processing.

  10. Quarterly technical progress report, October-December 1982 on Energy Conversion Research and Development Programs

    SciTech Connect

    Not Available

    1983-10-01

    In this quarterly technical progress report, UTSI reports on the continued design work for the low mass flow train superheater. The detailed design of this component continued and the overall arrangement drawing for the superheater and air heater was finalized. The air heater procurement reached the point of contract award, but the actual purchase order award was held up pending receipt of additional funding from the Department of Energy. Testing activity reported includes two additional tests in the LMF1C series, which concludes this test series. Test data are presented, along with preliminary analyses for the combustor, nozzle, diagnostic channel, diffuser, radiant furnace/secondary combustor and Materials Test Module. In addition to the nitrogen oxide test measurements, corrosion and erosion rates for the boiler tube specimens and the materials test module are reported.

  11. [Research guidance studies]. Quarterly progress report, October 1--December 31, 1997

    SciTech Connect

    Gray, D.; Tomlinson, G.

    1997-12-31

    The overall objectives of this contract are to: (1) evaluate the technical and economic merits of current direct and indirect coal liquefaction technologies and other similar emerging technologies such as coal-waste coprocessing, natural gas conversion, and biomass conversion technologies, (2) monitor progress in these technologies, (3) conduct specific and generic project economic and technical feasibility studies based on these technologies, (4) identify long-range R and D areas that have the greatest potential for process improvements, and (5) preliminarily investigate best configurations and associated costs for refining coal-derived and other non-conventional liquids in existing petroleum refineries. During this quarter, work was continued in the area of coal/oil coprocessing with existing petroleum refineries.

  12. Research in progress at the Institute for Computer Applications in Science and Engineering

    NASA Technical Reports Server (NTRS)

    1987-01-01

    This report summarizes research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis, and computer science during the period April 1, 1987 through October 1, 1987.

  13. Research in Chemical Kinetics: Progress Report, January 1, 1978 to September 30, 1978

    DOE R&D Accomplishments Database

    Rowland, F. S.

    1978-01-01

    Research was conducted on the following topics: stratospheric chemistry of chlorinated molecules, atmospheric chemistry of methane, atmospheric chemistry of cosmogenic tritium, reactions of energetic and thermal radioactive atoms, methylene chemistry, and laboratory simulation of chemical reactions in Jupiter atmosphere. (DLC)

  14. Research in elementary particle physics. Technical progress report, June 1, 1991--May 31, 1992

    SciTech Connect

    Kirsch, L.E.; Schnitzer, H.J.; Bensinger, J.R.; Blocker, C.A.

    1992-08-01

    This report discusses research in the following areas of high energy physics: B meson mixing; CDF response to low energy jets; jet scaling behavior; search for pair produced leptoquarks at CDF; SSC program; quantum field theory; and neural networks. (LSP).

  15. Community-level climate change vulnerability research: trends, progress, and future directions

    NASA Astrophysics Data System (ADS)

    McDowell, Graham; Ford, James; Jones, Julie

    2016-03-01

    This study systematically identifies, characterizes, and critically evaluates community-level climate change vulnerability assessments published over the last 25 years (n = 274). We find that while the field has advanced considerably in terms of conceptual framing and methodological approaches, key shortcomings remain in how vulnerability is being studied at the community-level. We argue that vulnerability research needs to more critically engage with the following: methods for evaluating future vulnerability, the relevance of vulnerability research for decision-making, interdependencies between social and ecological systems, attention to researcher / subject power dynamics, critical interpretation of key terms, and consideration of the potentially positive opportunities presented by a changing climate. Addressing these research needs is necessary for generating knowledge that supports climate-affected communities in navigating the challenges and opportunities ahead.

  16. [Research progress in biological basis of cold and heat essence of Chinese medicine].

    PubMed

    Yin, Yu-Ting; Li, Xiao-Wan; Dong, Yang; Shi, Jian-Rong

    2012-12-01

    Cold-heat problem is one core of traditional Chinese medicine theory. This paper summarizes the experimental research related to the biological basis of cold-heat essence in cold-heat syndrome, cold-heat body constitution and cold-heat property of Chinese herbs. In view of the classical physiological and biochemical indices, gene expression, protein expression and metabolic differences, differences in cold-heat syndrome or cold-heat constitution are mainly based on neurotransmitter, thyroid function, sex hormone, cyclic nucleotide system, and energy metabolism relating to the corresponding gene and protein expression. Furthermore, this paper analyses the change of correlation indices that accompany with a dynamic development process of "constitution-syndrome-herbal intervention", implying that the research of biological basis of cold-heat essence has turned from single index to multiple indices, and from dispersion research to system research. PMID:23257124

  17. Progress of cancer research on astrocyte elevated gene-1/Metadherin (Review).

    PubMed

    Huang, Yong; Li, LE-Ping

    2014-08-01

    Tumor development is initiated by an accumulation of numerous genetic and epigenetic alterations that promote tumor initiation, invasion and metastasis. Astrocyte elevated gene-1 [AEG-1; also known as Metadherin (MTDH) and Lysine-rich CEACAM1 co-isolated (LYRIC)] has emerged in recent years as a potentially crucial mediator of tumor malignancy, and a key converging point of a complex network of oncogenic signaling pathways. AEG-1/MTDH has a multifunctional role in tumor development that has been found to be involved in the following signaling cascades: i) The Ha-Ras and PI3K/Akt pathways; ii) the nuclear factor-κB signaling pathway; iii) the ERK/mitogen-activated protein kinase and Wnt/β-catenin pathways; and iv) the Aurora-A kinase signaling pathway. Studies have established that AEG-1/MTDH is crucial in tumor progression, including transformation, the evasion of apoptosis, invasion, angiogenesis and metastasis. In addition, recent clinical studies have convincingly associated AEG-1/MTDH with tumor progression and poor prognosis in a number of cancer types, including hepatocellular, esophageal squamous cell, gallbladder and renal cell carcinomas, breast, non-small cell lung, prostate, gastric and colorectal cancers, and glioma, melanoma, neuroblastoma and osteosarcoma. AEG-1/MTDH may be used as a biomarker to identify subgroups of patients who require more intensive treatments and who are likely to benefit from AEG-1/MTDH-targeted therapies. The therapeutic targeting of AEG-1/MTDH may simultaneously block metastasis, suppress tumor growth and enhance the efficacy of chemotherapeutic treatments. PMID:25009642

  18. CMC Research at NASA Glenn in 2014: Recent Progress and Plans

    NASA Technical Reports Server (NTRS)

    Grady, Joseph E.

    2014-01-01

    As part of NASA's Aeronautical Sciences project, Glenn Research Center has developed advanced fiber and matrix constituents for a 2700F CMC for turbine engine applications. Fiber, matrix and CMC development activities will be reviewed and the improvements in the properties and durability of each will be summarized. Plans for 2014 will be summarized, including fabrication and durability testing of the 2700F CMC and status updates on research collaborations underway with AFRL and DOE

  19. FY2010 Annual Progress Report for Energy Storage Research and Development

    SciTech Connect

    none,

    2011-01-28

    The energy storage research and development effort within the VT Program is responsible for researching and improving advanced batteries and ultracapacitors for a wide range of vehicle applications, including HEVs, PHEVs, EVs, and fuel cell vehicles (FCVs). Over the past few years, the emphasis of these efforts has shifted from high-power batteries for HEV applications to high-energy batteries for PHEV and EV applications.

  20. Jupiter Oxygen Corporation/Albany Research Center Crada Progress Report, September

    SciTech Connect

    Turner, Paul C.; Schoenfield, Mark

    2004-09-13

    The Albany Research Center (ARC) has developed a new Integrated Pollutant Removal (IPR) process for fossil-fueled boilers. Pursuant to a cooperative research and development agreement (CRADA) with Jupiter Oxygen Corporation, ARC currently is studying the IPR process as applied to the oxygen fuel technology developed by Jupiter. As discussed further below, these two new technologies are complementary. This interim report summarizes the study results to date and outlines the potential activities under the next phase of the CRADA with Jupiter.

  1. Proceedings of the technical review on advances in geothermal reservoir technology---Research in progress

    SciTech Connect

    Lippmann, M.J.

    1988-09-01

    This proceedings contains 20 technical papers and abstracts describing most of the research activities funded by the Department of Energy (DOE's) Geothermal Reservoir Technology Program, which is under the management of Marshall Reed. The meeting was organized in response to several requests made by geothermal industry representatives who wanted to learn more about technical details of the projects supported by the DOE program. Also, this gives them an opportunity to personally discuss research topics with colleagues in the national laboratories and universities.

  2. [National Institute for Petroleum and Energy Research], monthly progress report for March 1993

    SciTech Connect

    Not Available

    1993-04-01

    Accomplishments for the month of April are described briefly under tasks for: Energy Production Research; Fuels Research; and Supplemental Government Program. Energy Production Research includes: reservoir assessment and characterization; TORIS research support; development of improved microbial flooding methods; development of improved chemical flooding methods; development of improved alkaline flooding methods; mobility control and sweep improvement in chemical flooding; gas flood performance prediction improvement; mobility control, profile modification, and sweep improvement in gas flooding; three-phase relative permeability research; thermal processes for light oil recovery; thermal processes for heavy oil recovery; and imaging techniques applied to the study of fluids in porous media. Fuels Research includes: development of analytical methodology for analysis of heavy crudes; and thermochemistry and thermophysical properties of organic nigrogen- and diheteroatom-containing compounds. Supplemental Government Program includes: microbial-enhanced waterflooding field project; feasibility study of heavy oil recovery in the midcontinent region--Oklahoma, Kansas, and Missouri; surfactant- enhanced alkaline flooding field project; process- engineering property measurements on heavy petroleum components; development and application of petroleum production technologies; upgrade BPO crude oil data base; simulation analysis of steam-foam projects; DOE education initiative project; field application of foams of oil production symposium; technology transfer to independent producers; compilations and analysis of outcrop data from the Muddy and Almond formations; and horizontal well production from fractured reservoirs.

  3. Embryonic stem cell research: the relevance of ethics in the progress of science.

    PubMed

    Ruiz-Canela, Miguel

    2002-05-01

    Experimentation with embryonic stem (ES) cells has become an important breakthrough in medical research. However, it is also a source of controversy, because it requires the destruction of the human embryos used to derive ES cells. This paper deals with some of the ethical issues concerning ES cell research. To begin with, the terms used in the debate on the ethical status of the human embryo need to be defined. Apart from the presumed benefits of ES cell research, we should also consider such issues as the strong opposition to this research by a large part of society, who argue in favour of protecting and respecting human embryos; the fragility and defenseless of human embryos; and the contradiction in terms inherent in the statement that human embryos must be treated with respect. Secondly, we should focus on possible conflicts between the financial, scientific, and ethical aspects of this debate. Thirdly, the significance of social and political debate requires clear and complete information that takes all consequences into account. Finally, the paper suggests how multipotent adult stem cell research may be an optimal and realistic alternative to ES cell research. PMID:12011787

  4. [National Institute for Petroleum and Energy Research] monthly progress report, January 1993

    SciTech Connect

    Not Available

    1993-03-01

    Accomplishments for the month of January are briefly described for the following tasks: energy production research; fuels research; and supplemental government programs. Energy production research includes: reservoir assessment and characterization; TORI research support; development of improved microbial flooding methods; development of improved chemical flooding methods; development of improved alkaline flooding methods; mobility control and sweep improvement in chemical flooding; gas flood performance prediction improvement; mobility control, profile modifications, and sweep improvement in gas flooding; three-phase relative permeability research; thermal processes for light oil recovery; thermal processes for heavy oil recovery; and imaging techniques applied to the study of fluid in porous media. Fuel research includes: development of analytical methodology for analysis of heavy crudes; and thermochemistry and thermophysical properties of organic nitrogen and diheteroatom containing compounds. supplemental Government program includes: microbial-enhanced waterflooding field project; feasibility study of heavy oil recovery in the midcontinent region--Oklahoma, Kansas, and Missouri; surfactant- enhanced alkaline flooding field project; process-engineering property measurements on heavy petroleum components; development and application of petroleum production technologies; upgrade BPO crude oil data base; simulation analysis of steam-foam projects; DOE education initiative project; field application of foams for oil production symposium; technology transfer to independent producers; and compilations and analysis of outcrop data from the Muddy and Almond formations.

  5. National Institute for Petroleum and Energy Research monthly progress report, May 1993

    SciTech Connect

    Not Available

    1993-06-01

    Accomplishments for the month of May are described briefly under tasks for: Energy Production Research; Fuels Research; and Supplemental Government Program. Energy Production Research includes: reservoir assessment and characterization; TORIS research support; development of improved microbial flooding methods; development of improved chemical flooding methods; development of improved alkaline flooding methods; mobility control and sweep improvement in chemical flooding; gas flood performance prediction improvement; mobility control, profile modification, and sweep improvement in gas flooding; three-phase relative permeability research; thermal processes for light oil recovery; thermal processes for heavy oil recovery; and imaging techniques applied to the study of fluids in porous media. Fuels Research covers: development of analytical methodology for analysis of heavy crudes; and thermochemistry and thermophysical properties of organic nitrogen- and diheteratom-containing compounds. Supplemental Government Program covers: microbial-enhanced waterflooding field project; feasibility study of heavy oil recovery in the midcontinent region--Oklahoma, Kansas, and Missouri; surfactant-enhanced alkaline flooding field project; process-engineering property measurements on heavy petroleum components; development and application of petroleum production technologies; upgrade BPO crude oil data base; simulation analysis of steam-foam projects; DOE education initiative project; field application of foams for oil production symposium; technology transfer to independent producers; compilation and analysis of outcrop data from the Muddy and Almond formations; implementation of oil and gas technology transfer initiative; horizontal well production from fractured reservoirs; and chemical EOR workshop.

  6. (National Institute for Petroleum and Energy Research) monthly progress report for June 1992

    SciTech Connect

    Not Available

    1992-08-01

    Accomplishments for this period are described briefly under tasks for: Energy Production Research; Fuels Research; and Supplemental Government Program. Energy Production Research includes: reservoir assessment and characterization; TORIS research support; development of improved microbial flooding methods; surfactant flooding methods; development of improved alkaline flooding methods; mobility control and sweep improvement in chemical flooding; gas flood performance prediction improvement; mobility control, profile modification, and sweep improvement in gas flooding; three-phase relative permeability research; thermal processes for light oil recovery; thermal processes for heavy oil recovery; and imaging techniques applied to the study of fluid in porous media. Fuels research includes; development of analytical methodology for analysis of heavy crudes; and thermochemistry and thermophysical properties of organic nitrogen- and diheteroatom-containing compounds. Supplemental Government Program includes: microbial-enhanced waterflooding field project; feasibility study of heavy oil recovery in the midcontinent region--Oklahoma, Kansas, and Missouri; surfactant-enhanced alkaline flooding field project; development of methods for mapping distribution of clays in petroleum reservoirs; summary of geological and production characteristics of class 1, unstructured, deltaic reservoirs; third international reservoir characterization technical conference; process-engineering property measurements on heavy petroleum components; development and application of petroleum production technologies; upgrade BPO crude oil data base; simulation analysis of steam-foam projects; and analysis of the U. S. oil resource base and estimate of future recoverable oil.

  7. [National Institute for Petroleum and Energy Research] monthly progress report for June 1992

    SciTech Connect

    Not Available

    1992-08-01

    Accomplishments for this period are described briefly under tasks for: Energy Production Research; Fuels Research; and Supplemental Government Program. Energy Production Research includes: reservoir assessment and characterization; TORIS research support; development of improved microbial flooding methods; surfactant flooding methods; development of improved alkaline flooding methods; mobility control and sweep improvement in chemical flooding; gas flood performance prediction improvement; mobility control, profile modification, and sweep improvement in gas flooding; three-phase relative permeability research; thermal processes for light oil recovery; thermal processes for heavy oil recovery; and imaging techniques applied to the study of fluid in porous media. Fuels research includes; development of analytical methodology for analysis of heavy crudes; and thermochemistry and thermophysical properties of organic nitrogen- and diheteroatom-containing compounds. Supplemental Government Program includes: microbial-enhanced waterflooding field project; feasibility study of heavy oil recovery in the midcontinent region--Oklahoma, Kansas, and Missouri; surfactant-enhanced alkaline flooding field project; development of methods for mapping distribution of clays in petroleum reservoirs; summary of geological and production characteristics of class 1, unstructured, deltaic reservoirs; third international reservoir characterization technical conference; process-engineering property measurements on heavy petroleum components; development and application of petroleum production technologies; upgrade BPO crude oil data base; simulation analysis of steam-foam projects; and analysis of the U. S. oil resource base and estimate of future recoverable oil.

  8. Capsule Pipeline Research Center. 3-year Progress report, September 1, 1993--August 31, 1994

    SciTech Connect

    Not Available

    1994-04-01

    The Capsule Pipeline Research Center is devoted to performing research in capsule pipelines so that this emerging technology can be developed for early use to transport solids including coal, grain, other agricultural products, solid wastes, etc. Important research findings and accomplishments during the first-three years include: success in making durable binderless coal logs by compaction, success in underwater extrusion of binderless coal logs, success in compacting and extruding coal logs with less than 3% hydrophobic binder at room temperature, improvement in the injection system and the pump-bypass scheme, advancement in the state-of-the-art of predicting the energy loss (pressure drop) along both stationary and moving capsules, demonstrated the effectiveness of using polymer for drag reduction in CLP, demonstrated the influence of zeta potential on coal log fabrication, improved understanding of the water absorption properties of coal logs, better understanding of the mechanism of coal log abrasion (wear), completed a detailed economic evaluation of the CLP technology and compared coal transportation cost by CLP to that by rail, truck and slurry pipelines, and completion of several areas of legal research. The Center also conducted important technology transfer activities including workshops, work sessions, company seminars, involvement of companies in CLP research, issuance of newsletters, completion of a video tape on CLP, and presentation of research findings at numerous national and international meetings.

  9. Western Research Institute quarterly technical progress report, July--September 1993

    SciTech Connect

    Not Available

    1993-12-31

    Accomplishments for the quarter are described briefly for the following areas of research: oil shale; tar sand; coal; advanced exploratory process technology; and jointly sponsored research. Oil shale research covers process studies. Tar sand research is on recycle oil pyrolysis and extraction (ROPE{sup TM}) Process. Coal research includes: coal combustion; integrated coal processing concepts; and solid waste management. Advanced exploratory process technology includes: advanced process concepts; advanced mitigation concepts; and oil and gas technology. Jointly sponsored research covers: CROW{sup TM} field demonstration with Bell Lumber and Pole; operation and evaluation of the CO{sub 2} HUFF-N-PUFF Process; fly ash binder for unsurfaced road aggregates; solid state NMR analysis of Mesaverde group, Greater Green River Basin, tight gas sands; characterization of petroleum residua; shallow oil production using horizontal wells with enhanced oil recovery techniques; surface process study for oil recovery using a thermal extraction process; oil field waste cleanup using tank bottom recovery process; remote chemical sensor development; in situ treatment of manufactured gas plant contaminated soils demonstration program; solid state NMR analysis of Mowry formation shale from different sedimentary basins; solid state NMR analysis of naturally and artificially matured kerogens; and development of an effective method for the clean-up of natural gas.

  10. [National Institute for Petroleum and Energy Research] monthly progress report, July 1992

    SciTech Connect

    Not Available

    1992-09-01

    Accomplishments for the month of July are described briefly under tasks for: Energy Production Research; Fuels Research; and Supplemental Government Program. Energy Production Research includes: reservoir assessment and characterization; TORIS research support; development of improved microbial flooding methods; surfactant flooding methods; development of improved alkaline flooding methods; mobility control and sweep improvement in chemical flooding; gas flood performance prediction improvement; mobility control, profile modification, and sweep improvement in gas flooding; three-phase relative permeability research; thermal processes for light oil recovery; thermal processes for heavy oil recovery; and imaging techniques applied to the study of fluids in porous media. Fuel Research includes: development of analytical methodology for analysis of heavy crudes; and thermochemistry and thermophysical properties of organic nitrogen- and diheteroatom-containing compounds. Supplement Government Program includes: microbial-enhanced waterflooding field project; feasibility study of heavy oil recovery in the midcontinent region--Oklahoma, Kansas, and Missouri; surfactant-enhanced alkaline flooding field project; development of methods for mapping distribution of clays in petroleum reservoirs; summary of geological and production characteristics of class 1. unstructured, deltaic reservoirs; third international reservoir characterization technical conference; process-engineering property measurements on heavy petroleum components; development and application of petroleum production technologies; upgrade BPO crude oil data base; simulation analysis of steam-foam projects; analysis of the US oil resource base and estimate of future recoverable oil; DOE education initiative project; and technology transfer to independent producers.

  11. (National Institute for Petroleum and Energy Research) monthly progress report, July 1992

    SciTech Connect

    Not Available

    1992-09-01

    Accomplishments for the month of July are described briefly under tasks for: Energy Production Research; Fuels Research; and Supplemental Government Program. Energy Production Research includes: reservoir assessment and characterization; TORIS research support; development of improved microbial flooding methods; surfactant flooding methods; development of improved alkaline flooding methods; mobility control and sweep improvement in chemical flooding; gas flood performance prediction improvement; mobility control, profile modification, and sweep improvement in gas flooding; three-phase relative permeability research; thermal processes for light oil recovery; thermal processes for heavy oil recovery; and imaging techniques applied to the study of fluids in porous media. Fuel Research includes: development of analytical methodology for analysis of heavy crudes; and thermochemistry and thermophysical properties of organic nitrogen- and diheteroatom-containing compounds. Supplement Government Program includes: microbial-enhanced waterflooding field project; feasibility study of heavy oil recovery in the midcontinent region--Oklahoma, Kansas, and Missouri; surfactant-enhanced alkaline flooding field project; development of methods for mapping distribution of clays in petroleum reservoirs; summary of geological and production characteristics of class 1. unstructured, deltaic reservoirs; third international reservoir characterization technical conference; process-engineering property measurements on heavy petroleum components; development and application of petroleum production technologies; upgrade BPO crude oil data base; simulation analysis of steam-foam projects; analysis of the US oil resource base and estimate of future recoverable oil; DOE education initiative project; and technology transfer to independent producers.

  12. Chemistry and Materials Science progress report, first half FY 1992. Weapons-Supporting Research and Laboratory Directed Research and Development

    SciTech Connect

    Not Available

    1992-07-01

    This report contains sections on: Fundamentals of the physics and processing of metals; interfaces, adhesion, and bonding; energetic materials; plutonium research; synchrotron radiation-based materials science; atomistic approach to the interaction of surfaces with the environment: actinide studies; properties of carbon fibers; buried layer formation using ion implantation; active coherent control of chemical reaction dynamics; inorganic and organic aerogels; synthesis and characterization of melamine-formaldehyde aerogels; structural transformation and precursor phenomena in advanced materials; magnetic ultrathin films, surfaces, and overlayers; ductile-phase toughening of refractory-metal intermetallics; particle-solid interactions; electronic structure evolution of metal clusters; and nanoscale lithography induced chemically or physically by modified scanned probe microscopy.

  13. Design Research on Mathematics Education: Investigating the Progress of Indonesian Fifth Grade Students' Learning on Multiplication of Fractions with Natural Numbers

    ERIC Educational Resources Information Center

    Shanty, Nenden Octavarulia; Hartono, Yusuf; Putri, Ratu Ilma Indra; de Haan, Dede

    2011-01-01

    This study aimed at investigating the progress of students' learning on multiplication fractions with natural numbers through the five activity levels based on Realistic Mathematics Education (RME) approach proposed by Streefland. Design research was chosen to achieve this research goal. In design research, the Hypothetical Learning Trajectory…

  14. [Declassification productivity initiative]. Declassification Productivity Research Center progress report {number_sign}8, 1 January 1998--31 March 1998

    SciTech Connect

    1998-04-01

    The Declassification Productivity Research Center (DPRC) was established as an independent, world-class research capability and computer facility to support the DOE Declassification Productivity Initiative (DPI). The goal of DPI is to increase the flow of unrestricted government information to the public. This report documents progress during the second quarter of DPRC`s third year of operations. The DPRC has made very good progress this quarter, and has also begun several new projects with potential benefits for the declassification community. After significant delays, work is now progressing well on the Federal Intelligent Document Understanding Laboratory (FIDUL) project. The DPRC has become a familiar, respected member of the declassification community because of its efforts in the Declassification Productivity Management Council`s (DPMC`s) Automation Working Group (AWG). The DPRC provided a lead role and coordinating efforts in delivery of the AWG Electronic Document Interchange Standard (EDIS), and the associated (DPTC developed) (1) Document Interchange System (DIS) and (2) Document Review/Redaction System (DRS). These two PC based application systems are being offered free of charge, along with several other government-developed computer application programs, to smaller agencies which do not have the resources to purchase or develop such systems to support their declassification activities. The DPRC has also moved into a bigger facility at the GWU Virginia campus, which provides more space for expansion and for setting up the long envisioned DPRC Declassification Test Laboratory. Finally, the DPRC has also helped to develop a World Wide Web-based design concept and an operational prototype database system for one-stop coordination of multi-agency equity reviews. The Equity Notification Database (or END) is being developed to resolve difficulties being experienced by agencies engaged in and responsible for the review of documents with multiple equities.

  15. Notes on the progress and plans for educational research in the Socialist Republic of Vietnam

    NASA Astrophysics Data System (ADS)

    Fraser, Stewart E.

    1984-03-01

    Educational research in Vietnam is directed primarily by the National Institute of Educational Science (NIES), which consists of some thirteen specialised research departments. The Institute investigates various long-term aspects of educational policy reform, curriculum innovation and methodological approaches to education as well as more specialised fields such as `national-ethnic minorities' and `population education'. The major tasks of educational research in Vietnam have to be predicated on the demands of a developing society wishing to modernise its educational structure qualitatively while coping quantitatively with enormous population growth and a situation where school-age children currently comprise some 30% of the total population. Hence, harsh demographic realities and limited economic resources have to be offset, where possible, by efficient utilisation of the intellectual capital of the people and by the establishment of realistic educational priorities on the part of the government. These are amongst the major considerations of the NIES and are exemplified by the kind of research publications already emanating from the Institute as well as by the recently announced five-year plan for research development during the period 1981-1985.

  16. Nevada`s energy research strategy. Progress report, September 30, 1991--September 29, 1992

    SciTech Connect

    McNelis, D.N.

    1992-10-01

    This document was produced by the University and Community College System of Nevada (UCCSN) under a grant from the US Department of Energy (DOE) Office of Energy Research as part of the DOE-Experimental Program for the Simulation of Competitive Research (DOE-EPSCoR). The document develops Nevada`s strategies for the UCCSN to broaden and deepen energy-related research over the next five years in hydrology sciences, environmental biology and chemistry, chemical physics, and global change. A strategy was also developed to support energy-related research with education and human resources in science, math and engineering. A key concept of these strategies is continued success under the DOE-EPSCOR program. Participation in the Environmental Restoration and Waste Management, Civilian Radioactive Waste Management, Basic Energy Science and Global Climate Change programs in collaboration with the Nevada Test Site and DOE multi-program laboratories is also part of Nevada`s strategy for success in energy-related research.

  17. Savannah River Ecology Laboratory. Annual technical progress report of ecological research, period ending July 31, 1994

    SciTech Connect

    Not Available

    1994-07-31

    The Savannah River Ecology Laboratory (SREL) is a research unit of the University of Georgia (UGA) that is managed in conjunction with the University`s Institute of Ecology. The laboratory`s overall mission is to acquire and communicate knowledge of ecological processes and principles. SREL conducts basic and applied ecological research, as well as education and outreach programs, under an M&O contract with the US Department of Energy at the Savannah River Site. Significant accomplishments were made during the year ending July 31, 1994 in the areas of research, education and service. Reviewed in this document are research projects in the following areas: Environmental Operations Support (impacted wetlands, streams, trace organics, radioecology, database synthesis, wild life studies, zooplankton, safety and quality assurance); wood stork foraging and breeding ecology; defence waste processing facility; environmental risk assessment (endangered species, fish, ash basin studies); ecosystem alteration by chemical pollutants; wetlands systems; biodiversity on the SRS; Environmental toxicology; environmental outreach and education; Par Pond drawdown studies in wildlife and fish and metals; theoretical ecology; DOE-SR National Environmental Research Park; wildlife studies. Summaries of educational programs and publications are also give.

  18. [National Institute for Petroleum and Energy Research] monthly progress report for April 1992

    SciTech Connect

    Not Available

    1992-06-01

    Accomplishments for this period are described briefly under tasks for: Energy Production Research; Fuels Research; and Supplemental Government Program. Energy Production Research includes: reservoir assessment and characterization; TORIS research support; development of improved alkaline flooding methods, surfactant flooding methods; mobility control and sweep improvement in chemical flooding; gas flood performance prediction improvement; mobility control, profile modification, and sweep improvement in gas flooding; three-phase relative permeability; thermal processes for light oil recovery; thermal processes for heavy oil recovery; and imaging techniques applied to the study of fluids in porous media. Fuel Research includes: development of analytical methodology for analysis of heavy crudes; and thermochemistry and thermophysical properties of organic nitrogen- and diheteroatom-containing compounds. Supplemental Government Programs covers; field projects in microbial-enhanced waterflooding and surfactant-enhanced alkaline flooding; feasibility study of heavy oil recovery in the midcontinent region -- Oklahoma, Kansas, and Missouri; development of methods for mapping distribution of clays in petroleum reservoirs; summary of geological and production characteristics of class 1, unstructured, deltaic reservoirs; and process-engineering property measurements on heavy petroleum components.

  19. (National Institute for Petroleum and Energy Research) monthly progress report for April 1992

    SciTech Connect

    Not Available

    1992-06-01

    Accomplishments for this period are described briefly under tasks for: Energy Production Research; Fuels Research; and Supplemental Government Program. Energy Production Research includes: reservoir assessment and characterization; TORIS research support; development of improved alkaline flooding methods, surfactant flooding methods; mobility control and sweep improvement in chemical flooding; gas flood performance prediction improvement; mobility control, profile modification, and sweep improvement in gas flooding; three-phase relative permeability; thermal processes for light oil recovery; thermal processes for heavy oil recovery; and imaging techniques applied to the study of fluids in porous media. Fuel Research includes: development of analytical methodology for analysis of heavy crudes; and thermochemistry and thermophysical properties of organic nitrogen- and diheteroatom-containing compounds. Supplemental Government Programs covers; field projects in microbial-enhanced waterflooding and surfactant-enhanced alkaline flooding; feasibility study of heavy oil recovery in the midcontinent region -- Oklahoma, Kansas, and Missouri; development of methods for mapping distribution of clays in petroleum reservoirs; summary of geological and production characteristics of class 1, unstructured, deltaic reservoirs; and process-engineering property measurements on heavy petroleum components.

  20. Community Coordinated Modeling Center: Paving the Way for Progress in Space Science Research to Operational Space Weather Forecasting

    NASA Astrophysics Data System (ADS)

    Kuznetsova, M. M.; Maddox, M. M.; Mays, M. L.; Mullinix, R.; MacNeice, P. J.; Pulkkinen, A. A.; Rastaetter, L.; Shim, J.; Taktakishvili, A.; Zheng, Y.; Wiegand, C.

    2013-12-01

    Community Coordinated Modeling Center (CCMC) was established at the dawn of the millennium as an essential element on the National Space Weather Program. One of the CCMC goals was to pave the way for progress in space science research to operational space weather forecasting. Over the years the CCMC acquired the unique experience in preparing complex models and model chains for operational environment, in developing and maintaining powerful web-based tools and systems ready to be used by space weather service providers and decision makers as well as in space weather prediction capabilities assessments. The presentation will showcase latest innovative solutions for space weather research, analysis, forecasting and validation and review on-going community-wide initiatives enabled by CCMC applications.