Science.gov

Sample records for review identifying issues

  1. Thermal management in heavy vehicles : a review identifying issues and research requirements.

    SciTech Connect

    Wambsganss, M. W.

    1999-01-15

    Thermal management in heavy vehicles is cross-cutting because it directly or indirectly affects engine performance, fuel economy, safety and reliability, engine/component life, driver comfort, materials selection, emissions, maintenance, and aerodynamics. It follows that thermal management is critical to the design of large (class 6-8) trucks, especially in optimizing for energy efficiency and emissions reduction. Heat rejection requirements are expected to increase, and it is industry's goal to develop new, innovative, high-performance cooling systems that occupy less space and are lightweight and cost-competitive. The state of the art in heavy vehicle thermal management is reviewed, and issues and research areas are identified.

  2. Issues in Peer Review.

    ERIC Educational Resources Information Center

    Sawamura, Mark H.

    2001-01-01

    Based on concerns raised at a workshop at the Southern California College of Optometry, addresses critical issues in the process of peer review of faculty teaching and possible alternatives to these issues as applied to an optometric institution. (EV)

  3. Special Book Review Issue.

    ERIC Educational Resources Information Center

    Horvath, Clara, Ed.; And Others

    1996-01-01

    Reviews 32 books on the following topics: human resources and organizational development; guidance, assessment, and counseling; job search, networking, resumes, letters, and applications; careers in specific fields; transitions and retirement; and finding balance. (SK)

  4. PETC review: Issue 9

    SciTech Connect

    Santore, R.R.; Friedman, S.; Reiss, J.; Waehner, M.J.

    1993-12-31

    Since its beginning, Pittsburgh Energy Technology Center`s (PETC) primary function has been to study and conduct research on coal and its uses and applications. PETC has also been investigating ways in which natural gas can be employed to enhance the use of coal and to convert natural gas into liquid products that can be more readily transported and stored. This review contains five articles which reflect PETC`s mission: State-of-the-Art High Performance Power Systems [HIPPS]; Unconventional Fuel Uses of Natural Gas; Micronized Magnetite -- Beneficiation and Benefits; Reburning for NO{sub x} Reduction; and An Update of PETC`s Process Research Facility.

  5. Identifying Crucial Issues in Climate Science

    NASA Astrophysics Data System (ADS)

    Ikeda, Motoyoshi; Greve, Ralf; Hara, Toshika; Watanabe, Yutaka W.; Ohmura, Atsumu; Ito, Akihiko; Kawamiya, Michio

    2009-01-01

    Drastic Change in the Earth System During Global Warming; Sapporo, Japan, 24 June 2008; The Nobel Peace Prize awarded to the Intergovernmental Panel on Climate Change (IPCC) and former U.S. vice president Al Gore indicates that global warming is recognized as a real phenomenon critical to human beings. However, humanity's knowledge concerning global warming is based on an uncertainty larger than 50% in the warming rate during the past century. Therefore, scientific clarification is needed to understand important mechanisms that potentially produce positive feedbacks in the Earth system-such mechanisms must be better understood before scientists can develop more reliable predictions. To plan for the future, a symposium was organized at Japan's Hokkaido University in association with the G8 Summit, where the most recent updates on the five urgent issues in climate science were discussed. These issues, considered to be crucial as severe impacts on human society continue to rise, included (1) causes and magnitude of sea level rise; (2) decay of glaciers and the Greenland and Antarctic ice sheets; (3) disappearance of the summer Arctic sea ice; (4) carbon uptake or emission by the terrestrial ecosystem; and (5) marine ecosystem change resulting in carbon emissions.

  6. Critical Issues as Identified by Aspiring, Novice and Experienced Principals.

    ERIC Educational Resources Information Center

    Roberson, Thelma; Schweinle, William; Styron, Ron

    In spring 2003, more than 130 aspiring, novice, and experienced K-12 principals from public, private, and parochial schools were asked to identify in rank order the top 10 most critical issues facing schools. The issue most frequently identified as most critical was accountability, with staffing next, followed by discipline, time, funding,…

  7. Annual Review of Environmental Education. First Issue 1987.

    ERIC Educational Resources Information Center

    Annual Review of Environmental Education, 1987

    1987-01-01

    This document is the first issue of an annual journal produced by the Council of Environmental Education. It was designed to monitor the health of environmental education, help build coherence, identify gaps and issues, provide an evaluative review of the field, and present developments and practices in the field. Contained in this volume are…

  8. Recognizing and identifying people: A neuropsychological review.

    PubMed

    Barton, Jason J S; Corrow, Sherryse L

    2016-02-01

    Recognizing people is a classic example of a cognitive function that involves multiple processing stages and parallel routes of information. Neuropsychological data have provided important evidence for models of this process, particularly from case reports; however, the quality and extent of the data varies widely between studies. In this review we first discuss the requirements and logical basis of the types of neuropsychological evidence to support conclusions about the modules in this process. We then survey the adequacy of the current body of reports to address two key issues. First is the question of which cognitive operation generates a sense of familiarity: the current debate revolves around whether familiarity arises in modality-specific recognition units or later amodal processes. Key evidence on this point comes from the search for dissociations between familiarity for faces, voices and names. The second question is whether lesions can differentially affect the abilities to link diverse sources of person information (e.g., face, voice, name, biographic data). Dissociations of these linkages may favor a 'distributed-only' model of the organization of semantic knowledge, whereas a 'person-hub' model would predict uniform impairments of all linkages. While we conclude that there is reasonable evidence for dissociations in name, voice and face familiarity in regards to the first question, the evidence for or against dissociated linkages between information stores in regards to the second question is tenuous at best. We identify deficiencies in the current literature that should motivate and inform the design of future studies. PMID:26773237

  9. Fifth Annual EDUCAUSE Survey Identifies Current IT Issues

    ERIC Educational Resources Information Center

    Spicer, Donald Z.; DeBlois, Peter B.

    2004-01-01

    This year marks the fifth annual EDUCAUSE Current Issues Survey to identify what campus information technology leaders see as their most critical IT challenges. Thirty-five percent (571) of the 1,638 EDUCAUSE primary member representatives who were asked to participate responded to an e-mail invitation to complete the Web-based survey in December…

  10. Priority patient safety issues identified by perioperative nurses.

    PubMed

    Steelman, Victoria M; Graling, Paula R; Perkhounkova, Yelena

    2013-04-01

    Much of the work done by perioperative nurses focuses on patient safety. Perioperative nurses are aware that unreported near misses occur every day, and they use that knowledge to prioritize activities to protect the patient. The purpose of this study was to identify the highest priority patient safety issues reported by perioperative RNs. We sent a link to an anonymous electronic survey to all AORN members who had e-mail addresses in AORN's member database. The survey asked respondents to identify top perioperative patient safety issues. We received 3,137 usable responses and identified the 10 highest priority safety issues, including wrong site/procedure/patient surgery, retained surgical items, medication errors, failures in instrument reprocessing, pressure injuries, specimen management errors, surgical fires, perioperative hypothermia, burns from energy devices, and difficult intubation/airway emergencies. Differences were found among practice settings. The information from this study can be used to inform the development of educational programs and the allocation of resources to enhance safe perioperative patient care. PMID:23531307

  11. VLSI Technology: Impact and Promise. Identifying Emerging Issues and Trends in Technology for Special Education.

    ERIC Educational Resources Information Center

    Bayoumi, Magdy

    As part of a 3-year study to identify emerging issues and trends in technology for special education, this paper addresses the implications of very large scale integrated (VLSI) technology. The first section reviews the development of educational technology, particularly microelectronics technology, from the 1950s to the present. The implications…

  12. PETC Review, Issue 5, Spring 1992

    SciTech Connect

    Blaustein, B D; Reiss, J; Tarquinio, M A; Brown, J; Evans, E

    1992-04-01

    This issue of PETC Review contains short discussion on the following topics: advanced coal preparation processes, new scrubbers for flue gas desulfurization, PETC's Coal Preparation Process Research Facility, and PETC's Science Outreach Program. Supplemental sections on publications, highlights, calendars, etc. are also included. (VC)

  13. PETC Review, Issue 5, Spring 1992

    SciTech Connect

    Blaustein, B.D.; Reiss, J.; Tarquinio, M.A.; Brown, J.; Evans, E.

    1992-07-01

    This issue of PETC Review contains short discussion on the following topics: advanced coal preparation processes, new scrubbers for flue gas desulfurization, PETC`s Coal Preparation Process Research Facility, and PETC`s Science Outreach Program. Supplemental sections on publications, highlights, calendars, etc. are also included. (VC)

  14. School Counselors: A Review of Contemporary Issues

    ERIC Educational Resources Information Center

    Bain, Steve F.

    2012-01-01

    This article seeks to review the topic of school counselors and the contemporary issues surrounding this profession. An introduction to the profession and overview of its history provides a comprehensive basis on which to understand today's school counseling profession. An examination of contemporary themes of school counseling will include job…

  15. Peer Review of Grant Applications: A Simple Method to Identify Proposals with Discordant Reviews

    PubMed Central

    Giraudeau, Bruno; Leyrat, Clémence; Le Gouge, Amélie; Léger, Julie; Caille, Agnès

    2011-01-01

    Grant proposals submitted for funding are usually selected by a peer-review rating process. Some proposals may result in discordant peer-review ratings and therefore require discussion by the selection committee members. The issue is which peer-review ratings are considered as discordant. We propose a simple method to identify such proposals. Our approach is based on the intraclass correlation coefficient, which is usually used in assessing agreement in studies with continuous ratings. PMID:22110670

  16. Identity Management Systems in Healthcare: The Issue of Patient Identifiers

    NASA Astrophysics Data System (ADS)

    Soenens, Els

    According to a recent recommendation of the European Commission, now is the time for Europe to enhance interoperability in eHealth. Although interoperability of patient identifiers seems promising for matters of patient mobility, patient empowerment and effective access to care, we see that today there is indeed a considerable lack of interoperability in the field of patient identification. Looking from a socio-technical rather than a merely technical point of view, one can understand the fact that the development and implementation of an identity management system in a specific healthcare context is influenced by particular social practices, affected by socio-economical history and the political climate and regulated by specific data protection legislations. Consequently, the process of making patient identification in Europe more interoperable is a development beyond semantic and syntactic levels. In this paper, we gives some examples of today’s patient identifier systems in Europe, discuss the issue of interoperability of (unique) patient identifiers from a socio-technical point of view and try not to ignore the ‘privacy side’ of the story.

  17. Identifying Human Factors Issues in Aircraft Maintenance Operations

    NASA Technical Reports Server (NTRS)

    Veinott, Elizabeth S.; Kanki, Barbara G.; Shafto, Michael G. (Technical Monitor)

    1995-01-01

    Maintenance operations incidents submitted to the Aviation Safety Reporting System (ASRS) between 1986-1992 were systematically analyzed in order to identify issues relevant to human factors and crew coordination. This exploratory analysis involved 95 ASRS reports which represented a wide range of maintenance incidents. The reports were coded and analyzed according to the type of error (e.g, wrong part, procedural error, non-procedural error), contributing factors (e.g., individual, within-team, cross-team, procedure, tools), result of the error (e.g., aircraft damage or not) as well as the operational impact (e.g., aircraft flown to destination, air return, delay at gate). The main findings indicate that procedural errors were most common (48.4%) and that individual and team actions contributed to the errors in more than 50% of the cases. As for operational results, most errors were either corrected after landing at the destination (51.6%) or required the flight crew to stop enroute (29.5%). Interactions among these variables are also discussed. This analysis is a first step toward developing a taxonomy of crew coordination problems in maintenance. By understanding what variables are important and how they are interrelated, we may develop intervention strategies that are better tailored to the human factor issues involved.

  18. PETC Review, Issue 3, March 1991

    SciTech Connect

    Blaustein, B.; Reiss, J.; Robotti, S.; Brown, J.; Carter, C.; Evans, E.; Hammer, D.

    1991-03-01

    This issue of PETC Review presents brief discussion of the status of two DOE research program: (1)Coal Liquefaction and (2)Low-Cost Retrofit Technologies for Reducing SO{sub 2}, NO{sub x}, and Particulates as part of the Clean Coal Technology Program. Air Toxics and the 1990 Clean Air Act are also discussed with respect to Environmental Protection Agency regulations. Supplemental sections on events, special focuses, publication listing, etc. are also included.

  19. PETC Review, Issue 2, September 1990

    SciTech Connect

    Blaustein, B.; Reiss, J.; Riehle, B.; Brown, J.; Hammer, D.

    1990-09-01

    This issue of PETC Review provides short discussion on research programs in (1) combustion technology, (2) flue gas cleanup technology, (3) coal science and chemistry. An overview of the PETC New Fuels Evaluation Facility is given, the US Clean Coal Technology Program's activities in Poland are discussed, and the NOXSO flue gas cleanup process is outlined. Supplemental sections on events, special focuses, publication listings, etc. are also included.

  20. PETC Review, Issue 2, September 1990

    SciTech Connect

    Blaustein, B.; Reiss, J.; Riehle, B.; Brown, J.; Hammer, D.

    1990-09-01

    This issue of PETC Review provides short discussion on research programs in (1) combustion technology, (2) flue gas cleanup technology, (3) coal science and chemistry. An overview of the PETC New Fuels Evaluation Facility is given, the US Clean Coal Technology Program`s activities in Poland are discussed, and the NOXSO flue gas cleanup process is outlined. Supplemental sections on events, special focuses, publication listings, etc. are also included.

  1. Technical review of externalities issues. Final report

    SciTech Connect

    Niemeyer, V.

    1994-12-01

    Externalities has become the catchword for a major experiment in electric utility regulation. Together with increased competition as a means for economic regulation, this experiment represents a potential revolution in how electric utilities are regulated. It is very important for utilities and policy makers to understand the technical issues and arguments driving the externality experiment. This Technical Review presents four papers covering topics in economics that may play important roles in this revolution. The four papers are: Economic Issues in the Application of Externalities to Electricity Resource Selection; Climate Change, the Marginal Cost of Carbon Dioxide Emissions and the Implications for Carbon Dioxide Emissions Adders; Positive Externalities and Benefits from Electricity; and Socioeconomic Effects of Externality Adders for Electric Utility Emissions.

  2. PETC Review, Issue 1, March 1990

    SciTech Connect

    Blaustein, B.; Reiss, J.; Martin, G.; Hammer, D.; Mills, J.

    1990-03-01

    This issue of PETC Review contains short discussion on the following topics: (1) SO{sub 2} Control and Duct Injection: A Solution to Acid Rain''--research on duct injection; (2) Acid Rain Abatement and Advanced Coal Cleaning: A Precombustion Option''--research on selective agglomeration and advanced froth flotation; (3) Two-Stage Liquefaction of Coal''--PETC's efforts to further the viability of this technology; (4) Clean Coal Technology: Energy and the Environment''--the Clean Coal Technology Program is demonstrating technologies that show coal can be both efficient and environmentally acceptable. Supplemental sections on events, special focuses, calendars, publication lists, etc. are also included.

  3. PETC Review, Issue 1, March 1990

    SciTech Connect

    Blaustein, B.; Reiss, J.; Martin, G.; Hammer, D.; Mills, J.

    1990-03-01

    This issue of PETC Review contains short discussion on the following topics: (1)``SO{sub 2} Control and Duct Injection: A Solution to Acid Rain``--research on duct injection; (2)``Acid Rain Abatement and Advanced Coal Cleaning: A Precombustion Option``--research on selective agglomeration and advanced froth flotation; (3)``Two-Stage Liquefaction of Coal``--PETC`s efforts to further the viability of this technology; (4)``Clean Coal Technology: Energy and the Environment``--the Clean Coal Technology Program is demonstrating technologies that show coal can be both efficient and environmentally acceptable. Supplemental sections on events, special focuses, calendars, publication lists, etc. are also included.

  4. PETC Review, Issue 4, Fall 1991

    SciTech Connect

    Blaustein, B D; Reiss, J; Tarquinio, M A; Brown, J; Evans, E

    1991-10-01

    In this issue of PETC Review, short discussion is given on the following topics: (1) Combustion 2000''--a low-emission boiler system coupled to a high-performance power system; (2) Liquid Transportation Fuels from Coal, Part 2: Indirect Liquefaction''--outline research program; (3) A Computer Expert System to Reduce Power Plant Emissions''--a system being developed to predict the economic, operational, and environmental benefits of using commercially achievable cleaned coals; (4) PETC's Flow Analysis Laboratory Assists Artificial Heart Research''--PETC equipment used to study the flow of blood in artificial hearts. Supplemental sections on events, special focuses, calendars, publication lists, etc. are also included.

  5. PETC Review, Issue 4, Fall 1991

    SciTech Connect

    Blaustein, B.D.; Reiss, J.; Tarquinio, M.A.; Brown, J.; Evans, E.

    1991-12-31

    In this issue of PETC Review, short discussion is given on the following topics: (1) ``Combustion 2000``--a low-emission boiler system coupled to a high-performance power system; (2) ``Liquid Transportation Fuels from Coal, Part 2: Indirect Liquefaction``--outline research program; (3) ``A Computer Expert System to Reduce Power Plant Emissions``--a system being developed to predict the economic, operational, and environmental benefits of using commercially achievable cleaned coals; (4) ``PETC`s Flow Analysis Laboratory Assists Artificial Heart Research``--PETC equipment used to study the flow of blood in artificial hearts. Supplemental sections on events, special focuses, calendars, publication lists, etc. are also included.

  6. Analysis of Adverse Events in Identifying GPS Human Factors Issues

    NASA Technical Reports Server (NTRS)

    Adams, Catherine A.; Hwoschinsky, Peter V.; Adams, Richard J.

    2004-01-01

    The purpose of this study was to analyze GPS related adverse events such as accidents and incidents (A/I), Aviation Safety Reporting System (ASRS) reports and Pilots Deviations (PDs) to create a framework for developing a human factors risk awareness program. Although the occurrence of directly related GPS accidents is small the frequency of PDs and ASRS reports indicated there is a growing problem with situational awareness in terminal airspace related to different types of GPs operational issues. This paper addresses the findings of the preliminary research and a brief discussion of some of the literature on related GPS and automation issues.

  7. The IRS Work Plan: IRS Official Identifies Hot Issues.

    ERIC Educational Resources Information Center

    Owens, Marcus

    1993-01-01

    A federal tax official specializing in tax-exempt organizations discusses the relatively new use of coordinated examination audits. Significant issues being raised as the use of such audits expands are examined, including employment tax, contractors, withholding on students, unrelated business income, bond financing, the audit process, corporate…

  8. IDENTIFYING RECRUITMENT AND RETENTION ISSUES FOR THE NATIONAL CHILDREN'S STUDY

    EPA Science Inventory

    Recruitment and Retention Issues for the National Children's Study
    Danelle T Lobdell1, Suzanne Gilboa2, Pauline Mendola1 (1US EPA, NHEERL; 2UNC Chapel Hill)

    A better understanding of the most effective recruitment techniques and retention strategies for longitudinal, co...

  9. Key Issue: Identifying Professional Contexts to Support Highly Effective Teachers

    ERIC Educational Resources Information Center

    Hirsch, Eric

    2008-01-01

    Policymakers, practitioners, and researchers have long understood that teacher quality is the most important variable for the success of students. The context in which educators work is critical to their success and satisfaction; however, identifying and addressing the conditions that teachers want and need is difficult. Assessing context is not…

  10. PETC Review, Issue 6, Summer 1992

    SciTech Connect

    Santore, R.R.; Blaustein, B.D.; Reiss, J.; Brown, J.

    1992-10-01

    This issue of the PETC Review focuses on the Clean Coal Technology Demonstration Program. Several projects were completed recently and many more are beginning to generate data from operations, making this an ideal time to highlight this program. The program, which was initiated in 1986, now has 42 projects that represent a remarkable scope of activities ranging from the demonstration of improved retrofit components to the repowering of coal-fired electrical power plants with advanced systems. In 1986, when Congress committed the nation to this multi-billion dollar, multi-year demonstration program, the policy goals were clearly set forth and the funding was completely committed. I believe that defining and sticking to these goals and commitments has been critical to establishing substantial industry interest and investment, thereby enhancing the prospects for success. Both the public and private sectors were better able to establish priorities and to allocate resources to projects that best meet our nation`s energy and environmental needs. I believe that the Clean Coal Technology program will help fulfill the goals for coal that were recently reaffirmed in the National Energy Strategy: One Year Later-to maintain coal`s competitiveness and to create a favorable export market for US coal and coal technology.

  11. PETC Review, Issue 6, Summer 1992

    SciTech Connect

    Santore, R.R.; Blaustein, B.D.; Reiss, J.; Brown, J.

    1992-01-01

    This issue of the PETC Review focuses on the Clean Coal Technology Demonstration Program. Several projects were completed recently and many more are beginning to generate data from operations, making this an ideal time to highlight this program. The program, which was initiated in 1986, now has 42 projects that represent a remarkable scope of activities ranging from the demonstration of improved retrofit components to the repowering of coal-fired electrical power plants with advanced systems. In 1986, when Congress committed the nation to this multi-billion dollar, multi-year demonstration program, the policy goals were clearly set forth and the funding was completely committed. I believe that defining and sticking to these goals and commitments has been critical to establishing substantial industry interest and investment, thereby enhancing the prospects for success. Both the public and private sectors were better able to establish priorities and to allocate resources to projects that best meet our nation's energy and environmental needs. I believe that the Clean Coal Technology program will help fulfill the goals for coal that were recently reaffirmed in the National Energy Strategy: One Year Later-to maintain coal's competitiveness and to create a favorable export market for US coal and coal technology.

  12. Identifying Issues for Long-Term Data Understandability

    NASA Astrophysics Data System (ADS)

    Barkstrom, B. R.

    2001-12-01

    In the past decade, we have seen a serious effort to capture and make useful a record of Earth observations. While the EOSDIS effort has had some success, the longer term prospects for preserving our knowledge of how the Earth has changed must still overcome a number of difficult challenges. The first, and most important, may be moving from the expectation that we can produce a single system that will solve all of the difficulties. Rather, we need to begin to view what we do from the perspective of a continuously evolving digital library. There are several key issues we need to deal with in trying to bring about this shift in perception: {a.}{We need a stable data referencing approach - like a URI, but one that allows us to reference individual data elements and subsets, not just files or data products.} {b.}{We need more adaptive metadata - including metadata that allows us to tie together data sets maintained in different places by scientific tribes that are linguistically in different communities of discourse.} {c.}{We need more automated approaches to ensuring the documentation of data provenance and of the web of scientific discourse that goes on mostly in scientific journals.} {d.}{We need to find ways of preserving both the data and its web of meaning even while we have to transfer it from medium to medium and system to system. The easy part of the problem is transferring the data - and that's the part that's been discussed so far. The hard part is carrying the scholarly apparatus that allows us to accumulate knowledge about what's in the data.} {e.}{We need additional approaches to visualizing the connections between various data sets and of recording objects that experts find for deeper examination.}

  13. Genitourinary issues during spaceflight: a review.

    PubMed

    Jones, J A; Jennings, R; Pietryzk, R; Ciftcioglu, N; Stepaniak, P

    2005-12-01

    The genitourinary (GU) system is not uncommonly affected during previous spaceflights. GU issues that have been observed during spaceflight include urinary calculi, infections, retention, waste management, and reproductive. In-flight countermeasures for each of these issues are being developed to reduce the likelihood of adverse sequelae, due to GU issues during exploration-class spaceflight, to begin in 2018 with flights back to the Moon and on to Mars, according to the February 2004 Presendent's Vision for US Space Exploration. With implementation of a robust countermeasures program, GU issues should not have a significant threat for mission impact during future spaceflights. PMID:16391546

  14. Reviewing Academic Books: Are There Ethical Issues?

    ERIC Educational Resources Information Center

    Byrne, Edmund F.

    2002-01-01

    Discusses bias in academic book reviewing due to the hierarchy of perceived excellence promoted by the academic and publishing industries and that favors authors from the most prestigious universities. Focuses on pre-publication reviewing of philosophical work and considers anonymity in journal peer reviewing and transparency in academic book…

  15. Review of Social and Organizational Issues in Health Information Technology

    PubMed Central

    2015-01-01

    Objectives This paper reviews organizational and social issues (OSIs) in health information technology (HIT). Methods A review and synthesis of the literature on OSIs in HIT was conducted. Results Five overarching themes with respect to OSIs in HIT were identified and discussed: scope and frameworks for defining OSIs in HIT, context matters, process immaturity and complexity, trade-offs will happen and need to be discussed openly, and means of studying OSIs in HIT. Conclusions There is a wide body of literature that provides insight into OSIs in HIT, even if many of the studies are not explicitly labelled as such. The two biggest research needs are more explicit and theoretical studies of OSI in HITs and more research on integrating micro and macro perspectives of HIT use in organizations. PMID:26279951

  16. Identifying and quantifying urban recharge: a review

    NASA Astrophysics Data System (ADS)

    Lerner, David N.

    2002-02-01

    The sources of and pathways for groundwater recharge in urban areas are more numerous and complex than in rural environments. Buildings, roads, and other surface infrastructure combine with man-made drainage networks to change the pathways for precipitation. Some direct recharge is lost, but additional recharge can occur from storm drainage systems. Large amounts of water are imported into most cities for supply, distributed through underground pipes, and collected again in sewers or septic tanks. The leaks from these pipe networks often provide substantial recharge. Sources of recharge in urban areas are identified through piezometry, chemical signatures, and water balances. All three approaches have problems. Recharge is quantified either by individual components (direct recharge, water-mains leakage, septic tanks, etc.) or holistically. Working with individual components requires large amounts of data, much of which is uncertain and is likely to lead to large uncertainties in the final result. Recommended holistic approaches include the use of groundwater modelling and solute balances, where various types of data are integrated. Urban recharge remains an under-researched topic, with few high-quality case studies reported in the literature.

  17. Fixed or random effects meta-analysis? Common methodological issues in systematic reviews of effectiveness.

    PubMed

    Tufanaru, Catalin; Munn, Zachary; Stephenson, Matthew; Aromataris, Edoardo

    2015-09-01

    Systematic review aims to systematically identify, critically appraise, and summarize all relevant studies that match predefined criteria and answer predefined questions. The most common type of systematic review is that assessing the effectiveness of an intervention or therapy. In this article, we discuss some of the common methodological issues that arise when conducting systematic reviews and meta-analyses of effectiveness data, including issues related to study designs, meta-analysis, and the use and interpretation of effect sizes. PMID:26355603

  18. Virtual Reality and Its Potential Use in Special Education. Identifying Emerging Issues and Trends in Technology for Special Education.

    ERIC Educational Resources Information Center

    Woodward, John

    As part of a 3-year study to identify emerging issues and trends in technology for special education, this paper addresses the possible contributions of virtual reality technology to educational services for students with disabilities. An example of the use of virtual reality in medical imaging introduces the paper and leads to a brief review of…

  19. A review of ethical issues in transplantation.

    PubMed

    Rhodes, R

    1994-01-01

    Unavoidable and unique characteristics of the transplant surgeon's practice require difficult moral judgments. The two major areas of moral quandary are organ procurement and organ allocation. This paper outlines the key ethical issues in transplantation and draws attention to some of the recent literature that argues more specific issues in greater detail. The subjects discussed include brain death, living organ donation, procurement policies, organ sales, distributive justice, free riders (nondonators), duties and debts, and research. PMID:8183299

  20. Distributed Information System Development: Review of Some Management Issues

    NASA Astrophysics Data System (ADS)

    Mishra, Deepti; Mishra, Alok

    Due to the proliferation of the Internet and globalization, distributed information system development is becoming popular. In this paper we have reviewed some significant management issues like process management, project management, requirements management and knowledge management issues which have received much attention in distributed development perspective. In this literature review we found that areas like quality and risk management issues could get only scant attention in distributed information system development.

  1. Research Review: Issues in Magazine Journalism Education.

    ERIC Educational Resources Information Center

    King, Elliot

    1994-01-01

    Argues that, hobbled by an impoverished underlying model and a lack of resources, very little empirical research has explored magazine journalism education. Investigates the underlying model, reviews existing research, and offers an optimistic assessment about future research possibilities. (SR)

  2. Science and technology review, September 1998 issue

    SciTech Connect

    Smart, J

    1998-09-01

    This issue focuses on monitoring the Comprehensive Test Ban Treaty. A feature article on the history of the Laboratory is also included. Other articles highlight X-ray laser technology and the ground testing of microsatellites that emulates the free-floating environment of actual space flight

  3. Regents' Review. Volume 10, Issue 4

    ERIC Educational Resources Information Center

    Nevada System of Higher Education, 2008

    2008-01-01

    This issue of the newsletter includes: (1) CSN's Automotive Program: Training Tomorrow's Workforce Today; (2) Chair's Corner; (3) A Nation at Risk (editorial); (4) UNHSS Moves Forward With First Private Gift; and (5) Nevada Higher Education in the News. [Document published by the Board of Regents of the Nevada System of Higher Education.

  4. Review of Tax Policy and Reform Issues.

    ERIC Educational Resources Information Center

    MacPhail-Wilcox, Bettye

    1982-01-01

    Summarizes the activities of the 97th Congress on taxes. Reviews 1981 enactments and 1982 proposals regarding tax cuts, tax increases, indexing of tax brackets, interest earnings, depreciation, and business incentives. Examines tax administration problems and flat-rate tax proposals and discusses the progressive income tax. (Author/RW)

  5. Scientific review of great basin wildfire issues

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The University Nevada Reno, College of Agriculture and Resource Concepts Inc., co-sponsored a Great Basin Wildfire Forum in September 2007 to address a “Scientific Review of the Ecological and Management History of Great Basin Natural Resources and Recommendations to Achieve Ecosystem Restoration”. ...

  6. Scientific Review of Great Basin Wildfire Issues

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The University Nevada Reno, College of Agriculture and Resource Concepts Inc., co-sponsored a Great Basin Wildfire Forum in September 2007 to address a “Scientific Review of the Ecological and Management History of Great Basin Natural Resources and Recommendations to Achieve Ecosystem Restoration”. ...

  7. Delphi analysis: a technique for identifying and ranking environmental and natural resource policy issues

    SciTech Connect

    Leitch, J.A.; Leistritz, F.L.

    1984-01-01

    A Delphi-type survey and a consensus-building workshop were carried out to identify the most significant natural resource issues and problems emerging in the Great Plains and Rocky Mountain states. Approximately 107 issues initially were identified through a literature search and an inquiry Delphi round. Delphi round enabled the list to be narrowed to 25 issues. While consensus was found on the top 25 issues as a group, neither the Delphi panel nor the workshop participants agreed on the top five. Specific issues related to water and energy comprised the majority of those identified as most significant. Overall, the Delphi method appears to be a powerful and flexible tool for evaluating emerging environmental issues and problems. The analysis suggests that Delphi findings are quite robust with respect to minor changes in panel composition. Delphi thus appears to be an approach that may find increasing application in environmental policy analysis. 11 references, 3 figures, 4 tables.

  8. Peer review: issues in physical medicine and rehabilitation.

    PubMed

    Wagner, Amy K; Boninger, Michael L; Levy, Charles; Chan, Leighton; Gater, David; Kirby, R Lee

    2003-10-01

    Peer review, although the standard for evaluating scientific research, is not without flaws. Peer reviewers have been shown to be inconsistent and to miss major strengths and deficiencies in studies. Both reviewer and author biases, including conflicts of interest and positive outcome publication biases, are frequent topics of study and debate. Additional concerns have been raised regarding inappropriate authorship and adequate reporting of the ethical process involving human and animal experimentation. Despite these issues, a good peer review can provide positive feedback to authors and improve the quality of research reported in medical journals. This article reviews some issues and points of concern regarding the peer-review process, and it suggests guidelines for new (and established) reviewers in the area of physical medicine and rehabilitation. It also provides suggestions for editorial considerations and improvements in the peer-review process for physical medicine and rehabilitation research journals. PMID:14508411

  9. Gender issues in reproductive health: a review.

    PubMed

    Adinma, Echendu D; Adinma, Brian-D J I

    2011-01-01

    Gender, for its impact on virtually every contemporary life issue, can rightly be regarded as a foremost component of reproductive health. Reproductive health basically emphasises on people and their rights to sexuality, reproduction, and family planning, and the information to actualize these right, which has been inextricably linked to development at the International Conference on Population and Development (ICPD) held in Cairo, Egypt, in 1994. Women's sexual and reproductive rights became recognised as universal human right, violations of which occur in some reproductive health areas including gender concerns. Gender inequality and inequity encompass gender based violence as well as gender discrimination which cuts across the life cycle of the woman; attitudes, religious and cultural practices of various nations; and issues related to employment, economy, politics, and development. The redress of gender inequality is a collective responsibility of nations and supranational agencies. Nations should adopt a framework hinged on three pedestals--legal, institutional and policy, employing the three recommended approaches of equal treatment, positive action, and gender mainstreaming. PMID:21970255

  10. Clinical trial design issues raised during recombinant DNA advisory committee review of gene transfer protocols.

    PubMed

    Scharschmidt, Tiffany; Lo, Bernard

    2006-04-01

    Gene transfer clinical trial protocols are reviewed by the Recombinant DNA Advisory Committee (RAC). Identifying the design concerns and suggestions commonly raised during RAC review may help investigators and sponsors shorten the process of protocol development and improve the quality of gene transfer trials. We therefore examined 53 full public reviews of gene transfer clinical trial protocols performed by the RAC between December 2000 and June 2004 to determine what trial design concerns or suggestions RAC members raised during written review or public discussion or in the formal letter to investigators after the review was completed. We also determined how frequently these concerns were raised. We found that RAC members raised issues regarding selection of subjects in 89% of reviews, dose escalation in 77%, selection of safety end points in 76%, biological activity measures in 66%, and overall design in 60% of reviews. The most common issue raised by RAC reviewers was the need to exclude subjects at increased risk for adverse events. Furthermore, in 89% of reviews, at least one design issue pertaining to safety of participants was raised. In 91% of reviews, at least one design concern was presented as a written RAC recommendation or concern to the investigator after the public review. When submitting protocols for RAC review, investigators and sponsors might devote more attention to issues that RAC reviewers commonly raise. Such attention might help strengthen clinical trial protocols, shorten the protocol development process, and enhance the protection of research participants. PMID:16610932

  11. Homosexuality and Education: A Review of the Issue.

    ERIC Educational Resources Information Center

    Newton, David E.; Risch, Stephen J.

    1981-01-01

    In this three-part article, the authors outline some reasons that homosexuality is an issue which should concern educators, describe some pertinent facts about the origins and correlates of homosexual behavior, and review some specific issues about the presence of openly gay teachers in the public schools. (Author/SJL)

  12. Informal Reasoning Regarding Socioscientific Issues: A Critical Review of Research

    ERIC Educational Resources Information Center

    Sadler, Troy D.

    2004-01-01

    Socioscientific issues encompass social dilemmas with conceptual or technological links to science. The process of resolving these issues is best characterized by informal reasoning which describes the generation and evaluation of positions in response to complex situations. This article presents a critical review of research related to informal…

  13. Using focus groups to identify psychosocial issues of urban black individuals with diabetes.

    PubMed

    Anderson, R M; Barr, P A; Edwards, G J; Funnell, M M; Fitzgerald, J T; Wisdom, K

    1996-01-01

    The purpose of this focus group research was to identify issues that could serve as topics for a series of educational videos portraying psychosocial issues of urban black individuals with diabetes. Four focus groups involving 34 black adults were conducted in the Detroit area. Psychosocial issues were identified and rated in order of priority by an expert panel. The major psychosocial issues identified were the importance of food and eating in the black culture, the necessity for learning more about diabetes and its complications, learning to interact effectively with healthcare providers and systems, and the need for help and support in managing psychosocial issues related to diabetes. Black individuals with diabetes face unique psychosocial challenges. Focus groups are an effective method for obtaining relevant, culturally specific, in-depth information about living with diabetes from patients who are members of minority groups. PMID:8697953

  14. The Full Spectrum of Clinical Ethical Issues in Kidney Failure. Findings of a Systematic Qualitative Review

    PubMed Central

    Kahrass, Hannes; Strech, Daniel; Mertz, Marcel

    2016-01-01

    Background When treating patients with kidney failure, unavoidable ethical issues often arise. Current clinical practice guidelines some of them, but lack comprehensive information about the full range of relevant ethical issues in kidney failure. A systematic literature review of such ethical issues supports medical professionalism in nephrology, and offers a solid evidential base for efforts that aim to improve ethical conduct in health care. Aim To identify the full spectrum of clinical ethical issues that can arise for patients with kidney failure in a systematic and transparent manner. Method A systematic review in Medline (publications in English or German between 2000 and 2014) and Google Books (with no restrictions) was conducted. Ethical issues were identified by qualitative text analysis and normative analysis. Results The literature review retrieved 106 references that together mentioned 27 ethical issues in clinical care of kidney failure. This set of ethical issues was structured into a matrix consisting of seven major categories and further first and second-order categories. Conclusions The systematically-derived matrix helps raise awareness and understanding of the complexity of ethical issues in kidney failure. It can be used to identify ethical issues that should be addressed in specific training programs for clinicians, clinical practice guidelines, or other types of policies dealing with kidney failure. PMID:26938863

  15. Technology and Interactive Multimedia. Identifying Emerging Issues and Trends in Technology for Special Education.

    ERIC Educational Resources Information Center

    Ashton, Ray

    As part of a 3-year study to identify emerging issues and trends in technology for special education, this paper addresses the role of interactive multimedia, especially the digital, optical compact disc technologies, in providing instructional services to special education students. An overview identifies technological and economic trends,…

  16. Identifying and Resolving Issues in EnergyPlus and DOE-2 Window Heat Transfer Calculations

    SciTech Connect

    Booten, C.; Kruis, N.; Christensen, C.

    2012-08-01

    Issues in building energy software accuracy are often identified by comparative, analytical, and empirical testing as delineated in the BESTEST methodology. As described in this report, window-related discrepancies in heating energy predictions were identified through comparative testing of EnergyPlus and DOE-2. Multiple causes for discrepancies were identified, and software fixes are recommended to better align the models with the intended algorithms and underlying test data.

  17. A review of design issues specific to hypersonic flight vehicles

    NASA Astrophysics Data System (ADS)

    Sziroczak, D.; Smith, H.

    2016-07-01

    This paper provides an overview of the current technical issues and challenges associated with the design of hypersonic vehicles. Two distinct classes of vehicles are reviewed; Hypersonic Transports and Space Launchers, their common features and differences are examined. After a brief historical overview, the paper takes a multi-disciplinary approach to these vehicles, discusses various design aspects, and technical challenges. Operational issues are explored, including mission profiles, current and predicted markets, in addition to environmental effects and human factors. Technological issues are also reviewed, focusing on the three major challenge areas associated with these vehicles: aerothermodynamics, propulsion, and structures. In addition, matters of reliability and maintainability are also presented. The paper also reviews the certification and flight testing of these vehicles from a global perspective. Finally the current stakeholders in the field of hypersonic flight are presented, summarizing the active programs and promising concepts.

  18. Results From a Transitional-Year Program Director Survey: Identifying Crucial Issues and Concerns

    PubMed Central

    Craig, Steven R.; Smith, Hayden L.; Short, Matthew W.

    2012-01-01

    Background Transitional Year (TY) programs meet an important need by preparing residents for specialties that accept individuals after an initial preparatory year. To our knowledge, no surveys to date have been conducted to identify attributes of TY programs and concerns of TY program directors. Purpose The purpose of this study was to review TY program characteristics and identify critical issues and concerns of TY program directors (TYPDs). Methods A web-based, 22-question survey was sent to all 114 TYPDs of programs accredited by the Accreditation Council for Graduate Medical Education between January and April 2011. The survey included open-formatted and closed-formatted questions addressing program and institution demographics, program director time, administrative support, satisfaction, and future plans. Results The survey response rate was 86%. The median age of TY programs was 28 years, with few new programs. More than 80% of TY programs were conducted at community hospitals and university-affiliated community hospitals. Of the responding TYPDs, 17% had served less than 2 years, and 32% had served 10 years or more. Common sponsoring TY programs included internal medicine (88%), general surgery (42%), family medicine (25%), emergency medicine (24%), and pediatrics (18%). Overall, TYPDs were satisfied with their positions. They expressed concerns about inadequate time to complete duties, salary support, and administrative duties assigned to program coordinators. Forty-nine percent of TYPDs reported they planned to leave the position within the next 5 years. Conclusions Our survey provides useful information to assist institutions and the graduate medical education community in meeting the needs of TYPDs and strengthening TY programs. PMID:23451303

  19. Young Viewers/Film Review Supplement. Issue Number 2.

    ERIC Educational Resources Information Center

    Gaffney, Maureen, Ed.

    1980-01-01

    Designed for media specialists and educators, this issue reviews 19 short films produced between 1956 and 1978. Films range from 2 to 24 minutes in length and include both verbal and nonverbal live-action and animation films. Although most of the films are aimed at elementary-aged children, a few are also suitable for teenagers and adults. The…

  20. A Review of the Preservation Issues Associated with Digital Documents.

    ERIC Educational Resources Information Center

    Parkes, Mitchell

    1999-01-01

    Reviews issues associated with the preservation of digital documents and their long-term viability. Topics include characteristics of digital information; physical deterioration of digital documents; life spans of digital media; technological obsolescence; digital artifacts versus digital objects; access versus preservation; intellectual…

  1. Fear of Singing: Identifying and Assisting Singers with Chronic Anxiety Issues

    ERIC Educational Resources Information Center

    Barefield, Robert

    2012-01-01

    Singers are sometimes plagued by an ongoing sense of anxiety that has the potential to negatively affect their work. This article addresses the issue of chronic anxiety as distinct from the more frequently considered topic of performance anxiety. Strategies are outlined to help teachers identify and address this problem in to order to help…

  2. A Framework for Identifying Implementation Issues Affecting Extension Human Sciences Programming

    ERIC Educational Resources Information Center

    Abell, Ellen; Cummings, Rebekah; Duke, Adrienne M.; Marshall, Jennifer Wells

    2015-01-01

    Extension programs based on identified needs, relevant theory, and solid research too often fail to realize their objectives. Program implementation is acknowledged to contribute to program effectiveness, yet systematic attention has not been paid to the array of implementation issues that can complicate achieving program goals. We developed the…

  3. Ongoing ethical issues concerning authorship in biomedical journals: an integrative review.

    PubMed

    Kornhaber, Rachel Anne; McLean, Loyola M; Baber, Rodney J

    2015-01-01

    Health professionals publishing within the field of health sciences continue to experience issues concerning appropriate authorship, which have clinical, ethical, and academic implications. This integrative review sought to explore the key issues concerning authorship from a bioethical standpoint, aiming to explore the key features of the authorship debate. Studies were identified through an electronic search, using the PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Scopus databases of peer-reviewed research, published between 2009 and 2014, limited to English language research, with search terms developed to reflect the current issues of authorship. From among the 279 papers identified, 20 research papers met the inclusion criteria. Findings were compiled and then arranged to identify themes and relationships. The review incorporated a wide range of authorship issues encompassing equal-credited authors, honorary (guest/gift) and ghost authorship, perception/experiences of authorship, and guidelines/policies. This review suggests that the International Committee of Medical Journal Editors' (ICMJE) recommended guidelines for authorship are not reflected in current authorship practices within the domain of health sciences in both low-and high-impact-factor journals. This devaluing of the true importance of authorship has the potential to affect the validity of authorship, diminish the real contributions of the true authors, and negatively affect patient care. PMID:26257520

  4. Ongoing ethical issues concerning authorship in biomedical journals: an integrative review

    PubMed Central

    Kornhaber, Rachel Anne; McLean, Loyola M; Baber, Rodney J

    2015-01-01

    Health professionals publishing within the field of health sciences continue to experience issues concerning appropriate authorship, which have clinical, ethical, and academic implications. This integrative review sought to explore the key issues concerning authorship from a bioethical standpoint, aiming to explore the key features of the authorship debate. Studies were identified through an electronic search, using the PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Scopus databases of peer-reviewed research, published between 2009 and 2014, limited to English language research, with search terms developed to reflect the current issues of authorship. From among the 279 papers identified, 20 research papers met the inclusion criteria. Findings were compiled and then arranged to identify themes and relationships. The review incorporated a wide range of authorship issues encompassing equal-credited authors, honorary (guest/gift) and ghost authorship, perception/experiences of authorship, and guidelines/policies. This review suggests that the International Committee of Medical Journal Editors’ (ICMJE) recommended guidelines for authorship are not reflected in current authorship practices within the domain of health sciences in both low-and high-impact-factor journals. This devaluing of the true importance of authorship has the potential to affect the validity of authorship, diminish the real contributions of the true authors, and negatively affect patient care. PMID:26257520

  5. Identifying the Science and Technology Dimensions of Emerging Public Policy Issues through Horizon Scanning

    PubMed Central

    Parker, Miles; Acland, Andrew; Armstrong, Harry J.; Bellingham, Jim R.; Bland, Jessica; Bodmer, Helen C.; Burall, Simon; Castell, Sarah; Chilvers, Jason; Cleevely, David D.; Cope, David; Costanzo, Lucia; Dolan, James A.; Doubleday, Robert; Feng, Wai Yi; Godfray, H. Charles J.; Good, David A.; Grant, Jonathan; Green, Nick; Groen, Arnoud J.; Guilliams, Tim T.; Gupta, Sunjai; Hall, Amanda C.; Heathfield, Adam; Hotopp, Ulrike; Kass, Gary; Leeder, Tim; Lickorish, Fiona A.; Lueshi, Leila M.; Magee, Chris; Mata, Tiago; McBride, Tony; McCarthy, Natasha; Mercer, Alan; Neilson, Ross; Ouchikh, Jackie; Oughton, Edward J.; Oxenham, David; Pallett, Helen; Palmer, James; Patmore, Jeff; Petts, Judith; Pinkerton, Jan; Ploszek, Richard; Pratt, Alan; Rocks, Sophie A.; Stansfield, Neil; Surkovic, Elizabeth; Tyler, Christopher P.; Watkinson, Andrew R.; Wentworth, Jonny; Willis, Rebecca; Wollner, Patrick K. A.; Worts, Kim; Sutherland, William J.

    2014-01-01

    Public policy requires public support, which in turn implies a need to enable the public not just to understand policy but also to be engaged in its development. Where complex science and technology issues are involved in policy making, this takes time, so it is important to identify emerging issues of this type and prepare engagement plans. In our horizon scanning exercise, we used a modified Delphi technique [1]. A wide group of people with interests in the science and policy interface (drawn from policy makers, policy adviser, practitioners, the private sector and academics) elicited a long list of emergent policy issues in which science and technology would feature strongly and which would also necessitate public engagement as policies are developed. This was then refined to a short list of top priorities for policy makers. Thirty issues were identified within broad areas of business and technology; energy and environment; government, politics and education; health, healthcare, population and aging; information, communication, infrastructure and transport; and public safety and national security. PMID:24879444

  6. Identifying the science and technology dimensions of emerging public policy issues through horizon scanning.

    PubMed

    Parker, Miles; Acland, Andrew; Armstrong, Harry J; Bellingham, Jim R; Bland, Jessica; Bodmer, Helen C; Burall, Simon; Castell, Sarah; Chilvers, Jason; Cleevely, David D; Cope, David; Costanzo, Lucia; Dolan, James A; Doubleday, Robert; Feng, Wai Yi; Godfray, H Charles J; Good, David A; Grant, Jonathan; Green, Nick; Groen, Arnoud J; Guilliams, Tim T; Gupta, Sunjai; Hall, Amanda C; Heathfield, Adam; Hotopp, Ulrike; Kass, Gary; Leeder, Tim; Lickorish, Fiona A; Lueshi, Leila M; Magee, Chris; Mata, Tiago; McBride, Tony; McCarthy, Natasha; Mercer, Alan; Neilson, Ross; Ouchikh, Jackie; Oughton, Edward J; Oxenham, David; Pallett, Helen; Palmer, James; Patmore, Jeff; Petts, Judith; Pinkerton, Jan; Ploszek, Richard; Pratt, Alan; Rocks, Sophie A; Stansfield, Neil; Surkovic, Elizabeth; Tyler, Christopher P; Watkinson, Andrew R; Wentworth, Jonny; Willis, Rebecca; Wollner, Patrick K A; Worts, Kim; Sutherland, William J

    2014-01-01

    Public policy requires public support, which in turn implies a need to enable the public not just to understand policy but also to be engaged in its development. Where complex science and technology issues are involved in policy making, this takes time, so it is important to identify emerging issues of this type and prepare engagement plans. In our horizon scanning exercise, we used a modified Delphi technique. A wide group of people with interests in the science and policy interface (drawn from policy makers, policy adviser, practitioners, the private sector and academics) elicited a long list of emergent policy issues in which science and technology would feature strongly and which would also necessitate public engagement as policies are developed. This was then refined to a short list of top priorities for policy makers. Thirty issues were identified within broad areas of business and technology; energy and environment; government, politics and education; health, healthcare, population and aging; information, communication, infrastructure and transport; and public safety and national security. PMID:24879444

  7. Research Ethics Review: Identifying Public Policy and Program Gaps

    PubMed Central

    Strosberg, Martin A.; Gefenas, Eugenijus; Famenka, Andrei

    2014-01-01

    We present an analytical frame-work for use by fellows of the Fogarty International Center–sponsored Advanced Certificate Program in Research Ethics for Central and Eastern Europe to identify gaps in the public policies establishing research ethics review systems that impede them from doing their job of protecting human research subjects. The framework, illustrated by examples from post-Communist countries, employs a logic model based on the public policy and public management literature. This paper is part of a collection of papers analyzing the Fogarty International Center’s International Research Ethics Education and Curriculum program. PMID:24782068

  8. Institutional review board (IRB) and ethical issues in clinical research

    PubMed Central

    2012-01-01

    Clinical research has expanded tremendously in the past few decades and consequently there has been growing interest in the ethical guidelines that are being followed for the protection of human subjects. This review summarizes historical scandals and social responses chronologically from World War II to the Death of Ellen Roche (2001) to emphasize the lessons we must learn from history. International ethical guidelines for studies with human subjects are also briefly described in order to understand the circumstances of clinical research. The tasks and responsibilities of the institutions and investigators in human subject research to preserve the safety and welfare of research subjects are summarized. Next, several debated ethical issues and insights are arranged as controversial topics. This brief review and summary seeks to highlight important arguments and make suggestions to institutional review boards (IRBs) to contribute to the future evolution of ethics in clinical research as we advance forward. PMID:22323947

  9. Institutional review board (IRB) and ethical issues in clinical research.

    PubMed

    Kim, Won Oak

    2012-01-01

    Clinical research has expanded tremendously in the past few decades and consequently there has been growing interest in the ethical guidelines that are being followed for the protection of human subjects. This review summarizes historical scandals and social responses chronologically from World War II to the Death of Ellen Roche (2001) to emphasize the lessons we must learn from history. International ethical guidelines for studies with human subjects are also briefly described in order to understand the circumstances of clinical research. The tasks and responsibilities of the institutions and investigators in human subject research to preserve the safety and welfare of research subjects are summarized. Next, several debated ethical issues and insights are arranged as controversial topics. This brief review and summary seeks to highlight important arguments and make suggestions to institutional review boards (IRBs) to contribute to the future evolution of ethics in clinical research as we advance forward. PMID:22323947

  10. Ethical issues in rehabilitation: a qualitative analysis of dilemmas identified by occupational therapists.

    PubMed

    Foye, Sarah Jajesnica; Kirschner, Kristi L; Brady Wagner, Lynne C; Stocking, Carol; Siegler, Mark

    2002-01-01

    Little available research exists to address the range of ethical issues encountered by occupational therapists (OTs) in their daily clinical work. The few articles in the literature have tended to be case-based or anecdotal or have focused on professional issues rather than clinical issues. To characterize the array of clinical ethical issues in occupational therapy, we asked OTs in a free-standing academic rehabilitation hospital to describe in some detail up to three scenarios or situations from their clinical practice that raised morally troubling questions. A coding system was developed to preserve the richness of the detail but to allow for some categorization of the topics. A second section of the survey asked the therapists to rate whether various traditional ethics topics were of high, medium, or low interest to them. A third section asked that they identify the formats that would be most appealing to them for future educational interventions. Of the 56 therapists surveyed, 38 (or 68%) responded. The three self-generated topics mentioned most frequently by the therapists were (in decreasing order of frequency): reimbursement pressures, conflicts around goal setting, and patient/family refusal of team recommendations. The respondents were particularly interested in knowing more about patient-centered ethics topics, such as conflict resolution between teams and patients and the patient's role in decision making. Furthermore, they indicated a strong preference for interdisciplinary and interactive educational formats. PMID:14523711

  11. A review of breast cancer survivorship issues from survivors' perspectives.

    PubMed

    Cho, Jihyoung; Jung, So-Youn; Lee, Jung Eun; Shim, Eun-Jung; Kim, Nam Hyoung; Kim, Zisun; Sohn, Guiyun; Youn, Hyun Jo; Kim, Ku Sang; Kim, Hanna; Lee, Jong Won; Lee, Min Hyuk

    2014-09-01

    Despite the fact that more breast cancer survivors are currently enjoying longer lifespans, there remains limited knowledge about the factors and issues that are of greatest significance for these survivors, particularly from their perspectives. This review was based on the concept that the topics addressed should focus on the perspectives of current survivors and should be extended to future modalities, which physicians will be able to use to gain a better understanding of the hidden needs of these patients. We intended to choose and review dimensions other than the pathology and the disease process that could have been overlooked during treatment. The eight topics upon which we focused included: delay of treatment and survival outcome; sexual well-being; concerns about childbearing; tailored follow-up; presence of a family history of breast cancer; diet and physical activity for survivors and their families; qualitative approach toward understanding of breast cancer survivorship, and; mobile health care for breast cancer survivors. Through this review, we aimed to examine the present clinical basis of the central issues noted from the survivors' perspectives and suggest a direction for future survivorship-related research. PMID:25320616

  12. A review of contemporary modalities for identifying abnormal fetal growth.

    PubMed

    O'Connor, C; Stuart, B; Fitzpatrick, C; Turner, M J; Kennelly, M M

    2013-04-01

    Detecting aberrant fetal growth has long been an important goal of modern obstetrics. Failure to diagnose abnormal fetal growth results in perinatal morbidity or mortality. However, the erroneous diagnosis of abnormal growth may lead to increased maternal anxiety and unnecessary obstetric interventions. We review the aetiology of deviant fetal growth and its implications both for the neonatal period and later in adult life. We examine maternal factors that may influence fetal growth such as obesity, glycaemic control and body composition. We discuss novel ways to improve our detection of abnormal fetal growth with a view to optimising antenatal care and clinical outcomes. These include using customised centiles or individualised growth assessment methods to improve accuracy. The role of fetal subcutaneous measurements as a surrogate marker of the nutritional status of the baby is also discussed. Finally, we investigate the role of Doppler measurements in identifying growth-restricted babies. PMID:23550849

  13. Measuring persistence: A literature review focusing on methodological issues

    SciTech Connect

    Wolfe, A.K.; Brown, M.A.; Trumble, D.

    1995-03-01

    This literature review was conducted as part of a larger project to produce a handbook on the measurement of persistence. The past decade has marked the development of the concept of persistence and a growing recognition that the long-term impacts of demand-side management (DSM) programs warrant careful assessment. Although Increasing attention has been paid to the topic of persistence, no clear consensus has emerged either about its definition or about the methods most appropriate for its measurement and analysis. This project strives to fill that gap by reviewing the goals, terminology, and methods of past persistence studies. It was conducted from the perspective of a utility that seeks to acquire demand-side resources and is interested in their long-term durability; it was not conducted from the perspective of the individual consumer. Over 30 persistence studies, articles, and protocols were examined for this report. The review begins by discussing the underpinnings of persistence studies: namely, the definitions of persistence and the purposes of persistence studies. Then. it describes issues relevant to both the collection and analysis of data on the persistence of energy and demand savings. Findings from persistence studies also are summarized. Throughout the review, four studies are used repeatedly to illustrate different methodological and analytical approaches to persistence so that readers can track the data collection. data analysis, and findings of a set of comprehensive studies that represent alternative approaches.

  14. Identifying Ethical Issues in Mental Health Research with Minors Adolescents: Results of a Delphi Study.

    PubMed

    Hiriscau, Elisabeta Ioana; Stingelin-Giles, Nicola; Wasserman, Danuta; Reiter-Theil, Stella

    2016-01-01

    Research with minors, especially for preventive purposes, e.g., suicide prevention, investigating risk or self-destructive behaviors such as deviance, drug abuse, or suicidal behavior, is ethically sensitive. We present a Delphi study exploring the ethical implications of the needs formulated by researchers in an international pre-conference who would benefit from ethics support and guidance in conducting Mental Health Research with minors. The resulting List of Ethical Issues (LEI) was submitted to a 2-rounds Delphi process via the Internet, including 34 multidisciplinary experts. In the first round, the experts reviewed the LEI and completed a questionnaire. Results from this round were analyzed and grouped in nine categories comprising 40 items. In the second round, the experts had to agree/disagree with the needs expressed in the LEI leading to a final list of 25 ethical issues considered relevant for Mental Health Research with minors such as: confidentiality of the sensitive data, competence for consenting alone and risk of harm and stigma related to the methodology used in research. It was shown that studies like SEYLE (Saving and Empowering Young Lives in Europe) trigger among researchers wishes to obtain specific recommendations helping to comply with standards for good practice in conducting research with minors. PMID:27187425

  15. Identifying Ethical Issues in Mental Health Research with Minors Adolescents: Results of a Delphi Study

    PubMed Central

    Hiriscau, Elisabeta Ioana; Stingelin-Giles, Nicola; Wasserman, Danuta; Reiter-Theil, Stella

    2016-01-01

    Research with minors, especially for preventive purposes, e.g., suicide prevention, investigating risk or self-destructive behaviors such as deviance, drug abuse, or suicidal behavior, is ethically sensitive. We present a Delphi study exploring the ethical implications of the needs formulated by researchers in an international pre-conference who would benefit from ethics support and guidance in conducting Mental Health Research with minors. The resulting List of Ethical Issues (LEI) was submitted to a 2-rounds Delphi process via the Internet, including 34 multidisciplinary experts. In the first round, the experts reviewed the LEI and completed a questionnaire. Results from this round were analyzed and grouped in nine categories comprising 40 items. In the second round, the experts had to agree/disagree with the needs expressed in the LEI leading to a final list of 25 ethical issues considered relevant for Mental Health Research with minors such as: confidentiality of the sensitive data, competence for consenting alone and risk of harm and stigma related to the methodology used in research. It was shown that studies like SEYLE (Saving and Empowering Young Lives in Europe) trigger among researchers wishes to obtain specific recommendations helping to comply with standards for good practice in conducting research with minors. PMID:27187425

  16. Summary of SMIRT20 Preconference Topical Workshop – Identifying Structural Issues in Advanced Reactors

    SciTech Connect

    William Richins; Stephen Novascone; Cheryl O'Brien

    2009-08-01

    Summary of SMIRT20 Preconference Topical Workshop – Identifying Structural Issues in Advanced Reactors William Richins1, Stephen Novascone1, and Cheryl O’Brien1 1Idaho National Laboratory, US Dept. of Energy, Idaho Falls, Idaho, USA, e-mail: William.Richins@inl.gov The Idaho National Laboratory (INL, USA) and IASMiRT sponsored an international forum Nov 5-6, 2008 in Porvoo, Finland for nuclear industry, academic, and regulatory representatives to identify structural issues in current and future advanced reactor design, especially for extreme conditions and external threats. The purpose of this Topical Workshop was to articulate research, engineering, and regulatory Code development needs. The topics addressed by the Workshop were selected to address critical industry needs specific to advanced reactor structures that have long lead times and can be the subject of future SMiRT technical sessions. The topics were; 1) structural/materials needs for extreme conditions and external threats in contemporary (Gen. III) and future (Gen. IV and NGNP) advanced reactors and 2) calibrating simulation software and methods that address topic 1 The workshop discussions and research needs identified are presented. The Workshop successfully produced interactive discussion on the two topics resulting in a list of research and technology needs. It is recommended that IASMiRT communicate the results of the discussion to industry and researchers to encourage new ideas and projects. In addition, opportunities exist to retrieve research reports and information that currently exists, and encourage more international cooperation and collaboration. It is recommended that IASMiRT continue with an off-year workshop series on select topics.

  17. 10 CFR Appendix Q to Part 50 - Pre-Application Early Review of Site Suitability Issues

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Pre-Application Early Review of Site Suitability Issues Q... FACILITIES Pt. 50, App. Q Appendix Q to Part 50—Pre-Application Early Review of Site Suitability Issues This... Reactor Safeguards of requests for early review of one or more site suitability issues relating to...

  18. 10 CFR Appendix Q to Part 50 - Pre-Application Early Review of Site Suitability Issues

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Pre-Application Early Review of Site Suitability Issues Q... FACILITIES Pt. 50, App. Q Appendix Q to Part 50—Pre-Application Early Review of Site Suitability Issues This... Reactor Safeguards of requests for early review of one or more site suitability issues relating to...

  19. 10 CFR Appendix Q to Part 50 - Pre-Application Early Review of Site Suitability Issues

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Pre-Application Early Review of Site Suitability Issues Q... FACILITIES Pt. 50, App. Q Appendix Q to Part 50—Pre-Application Early Review of Site Suitability Issues This... Reactor Safeguards of requests for early review of one or more site suitability issues relating to...

  20. Ethics and Neuropsychiatric Genetics: A Review of Major Issues

    PubMed Central

    Hoge, Steven K.; Appelbaum, Paul S.

    2012-01-01

    Advances in neuropsychiatric genetics hold great hopes for improved prevention, diagnosis, and treatment. However, the power of genetic testing to identify individuals at increased risk for disorders and to convey information about relatives creates a set of complex ethical issues. Public attitudes are inevitably affected by the shadow of eugenics, with its history of distorting scientific findings to serve socio-political ends. Nonetheless, the growing availability of genetic tests means that more patients will seek genetic information, and physicians must manage the process of informed consent to allow meaningful decisions. Patients should be helped to understand the often-limited predictive power of current knowledge, potential psychological impact, risks of stigma and discrimination, and possible implications for family members. Decisions for predictive testing of children raise additional concerns, including distortions of family dynamics and negative effects on children’s self-image; testing is best deferred until adulthood unless preventive interventions exist. Pharmacogenomic testing, part of personalized medicine, may bring collateral susceptibility information for which patients should be prepared. The implications of genetic findings for families raise the question of whether physicians have duties to inform family members of implications for their health. Finally, participation in research in neuropsychiatric genetics evokes a broad range of ethical concerns, including the contentious issue of the extent to which results should be returned to individual subjects. As genetic science becomes more widely applied, the public will become more sophisticated and will be likely to demand a greater role in determining social policy on these issues. PMID:22272758

  1. Identifying Lesbian, Gay, Bisexual, and Transgender Search Terminology: A Systematic Review of Health Systematic Reviews.

    PubMed

    Lee, Joseph G L; Ylioja, Thomas; Lackey, Mellanye

    2016-01-01

    Research on the health of lesbian, gay, bisexual, and transgender (LGBT) populations can provide important information to address existing health inequalities. Finding existing research in LGBT health can prove challenging due to the plethora of terminology used. We sought to describe existing search strategies and to identify more comprehensive LGBT search terminology. We iteratively created a search string to identify systematic reviews and meta-analyses about LGBT health and implemented it in Embase, PubMed/MEDLINE, and PsycINFO databases on May 28-29, 2015. We hand-searched the journal LGBT Health. Inclusion criteria were: systematic reviews and meta-analyses that addressed LGBT health, used systematic searching, and used independent coders for inclusion. The published search terminology in each record and search strings provided by authors on request were cross-referenced with our original search to identify additional terminology. Our search process identified 19 systematic reviews meeting inclusion criteria. The number of search terms used to identify LGBT-related records ranged from 1 to 31. From the included studies, we identified 46 new search terms related to LGBT health. We removed five search terms as inappropriate and added five search terms used in the field. The resulting search string included 82 terms. There is room to improve the quality of searching and reporting in LGBT health systematic reviews. Future work should attempt to enhance the positive predictive value of LGBT health searches. Our findings can assist LGBT health reviewers in capturing the diversity of LGBT terminology when searching. PMID:27219460

  2. Identifying Lesbian, Gay, Bisexual, and Transgender Search Terminology: A Systematic Review of Health Systematic Reviews

    PubMed Central

    Lee, Joseph G. L.; Ylioja, Thomas; Lackey, Mellanye

    2016-01-01

    Research on the health of lesbian, gay, bisexual, and transgender (LGBT) populations can provide important information to address existing health inequalities. Finding existing research in LGBT health can prove challenging due to the plethora of terminology used. We sought to describe existing search strategies and to identify more comprehensive LGBT search terminology. We iteratively created a search string to identify systematic reviews and meta-analyses about LGBT health and implemented it in Embase, PubMed/MEDLINE, and PsycINFO databases on May 28–29, 2015. We hand-searched the journal LGBT Health. Inclusion criteria were: systematic reviews and meta-analyses that addressed LGBT health, used systematic searching, and used independent coders for inclusion. The published search terminology in each record and search strings provided by authors on request were cross-referenced with our original search to identify additional terminology. Our search process identified 19 systematic reviews meeting inclusion criteria. The number of search terms used to identify LGBT-related records ranged from 1 to 31. From the included studies, we identified 46 new search terms related to LGBT health. We removed five search terms as inappropriate and added five search terms used in the field. The resulting search string included 82 terms. There is room to improve the quality of searching and reporting in LGBT health systematic reviews. Future work should attempt to enhance the positive predictive value of LGBT health searches. Our findings can assist LGBT health reviewers in capturing the diversity of LGBT terminology when searching. PMID:27219460

  3. Mobile healthcare applications: system design review, critical issues and challenges.

    PubMed

    Baig, Mirza Mansoor; GholamHosseini, Hamid; Connolly, Martin J

    2015-03-01

    Mobile phones are becoming increasingly important in monitoring and delivery of healthcare interventions. They are often considered as pocket computers, due to their advanced computing features, enhanced preferences and diverse capabilities. Their sophisticated sensors and complex software applications make the mobile healthcare (m-health) based applications more feasible and innovative. In a number of scenarios user-friendliness, convenience and effectiveness of these systems have been acknowledged by both patients as well as healthcare providers. M-health technology employs advanced concepts and techniques from multidisciplinary fields of electrical engineering, computer science, biomedical engineering and medicine which benefit the innovations of these fields towards healthcare systems. This paper deals with two important aspects of current mobile phone based sensor applications in healthcare. Firstly, critical review of advanced applications such as; vital sign monitoring, blood glucose monitoring and in-built camera based smartphone sensor applications. Secondly, investigating challenges and critical issues related to the use of smartphones in healthcare including; reliability, efficiency, mobile phone platform variability, cost effectiveness, energy usage, user interface, quality of medical data, and security and privacy. It was found that the mobile based applications have been widely developed in recent years with fast growing deployment by healthcare professionals and patients. However, despite the advantages of smartphones in patient monitoring, education, and management there are some critical issues and challenges related to security and privacy of data, acceptability, reliability and cost that need to be addressed. PMID:25476753

  4. Isoflavones and Prostate Cancer: A Review of Some Critical Issues

    PubMed Central

    Zhang, Hong-Yi; Cui, Jie; Zhang, Ye; Wang, Zhen-Long; Chong, Tie; Wang, Zi-Ming

    2016-01-01

    Objective: The purpose of this review is to discuss some critical issues of isoflavones protective against the development of prostate cancer (PCa). Data Sources: Data cited in this review were obtained primarily from PubMed and Embase from 1975 to 2015. Study Selection: Articles were selected with the search terms “isoflavone”, “Phytoestrogen”, “soy”, “genistin”, and “PCa”. Results: Isoflavones do not play an important role on prostate-specific antigen levels reduction in PCa patients or healthy men. The effect of isoflavones on sex hormone levels and PCa risk may be determined by equol converting bacteria in the intestine, specific polymorphic variation and concentrations of isoflavones. The intake of various types of phytoestrogens with lower concentrations in the daily diet may produce synergistic effects against PCa. Moreover, prostate tissue may concentrate isoflavones to potentially anti-carcinogenic levels. In addition, it is noteworthy that isoflavones may act as an agonist in PCa. Conclusions: Isoflavones play a protective role against the development of PCa. However, careful consideration should be given when isoflavones are used in the prevention and treatment of PCa. PMID:26831238

  5. Mental Health Needs of People Who Identify as Transgender: A Review of the Literature.

    PubMed

    McCann, Edward; Sharek, Danika

    2016-04-01

    Transgender people face many challenges in society including accessing and using healthcare systems. However, little is known about the specific mental health service needs and concerns of transgender people in this regard. The aim of the study was to establish the mental health service needs of transgender people through a review of relevant studies that address the experiences and views of this group. A comprehensive search of CINHAL, Cochrane, Google Scholar, PubMed, PsychInfo, PsychLit, Sociological Abstracts, Scopus, and Web of Science databases from inception to January 2014 was conducted. Studies were identified that met specific criteria that included: using qualitative methods, involving transgender people, and addressing issues related to mental health services. The search yielded 217 papers in total. Following the application of rigorous inclusion and exclusion criteria 33 papers were included for retrieval. Finally, 10 papers were considered suitable for the review. The data were analyzed and key themes identified. The review highlighted distinct challenges that exist in terms of mental health service provision. These included accessing appropriate services and treatments, responsiveness of practitioner's, the provision of family supports and potential mental health service developments. The review findings are discussed and key recommendations are made in terms of mental health nursing practice developments, education and research. PMID:26992883

  6. Identifying priority medicines policy issues for New Zealand: a general inductive study

    PubMed Central

    Babar, Zaheer-Ud-Din; Francis, Susan

    2014-01-01

    Objectives To identify priority medicines policy issues for New Zealand. Setting Stakeholders from a broad range of healthcare and policy institutions including primary, secondary and tertiary care. Participants Exploratory, semistructured interviews were conducted with 20 stakeholders throughout New Zealand. Primary and secondary outcome measures The interviews were digitally recorded, transcribed and coded into INVIVO 10, then compared and grouped for similarity of theme. Perceptions, experiences and opinions regarding New Zealand's medicines policy issues were recorded. Results A large proportion of stakeholders appeared to be unaware of New Zealand's (NZ) medicines policy. In general, the policy was considered to offer consistency to guide decision-making. In the context of Pharmaceutical Management Agency's (PHARMAC's) fixed budget for procuring and subsidising medicines, there was reasonable satisfaction with the range of medicines available—rare disorder medicines being the clear exception. Concerns raised were by whom and how decisions are made and whether desired health outcomes are being measured. Other concerns included inconsistencies in evidence and across health technologies. Despite attempts to improve the situation, lower socioeconomic groups (including rural residents) Māori and Pacific ethnicities and people with rare disorders face challenges with regards to accessing medicines. Other barriers include, convenience to and affordability of prescribers and the increase of prescription fees from NZ$3 to NZ$5. Concerns related to the PHARMAC of New Zealand included: a constraining budget; non-transparency of in-house analysis; lack of consistency in recommendations between the Pharmacology and Therapeutics Advisory Committee. Constraints and inefficiencies also exist in the submission process to access high-cost medicines. Conclusions The results suggest reasonable satisfaction with the availability of subsidised medicines. However, some of the

  7. Nephrologists as primary care providers: a review of the issues.

    PubMed

    Holley, J L

    1998-04-01

    Considering the role of nephrologists as primary care providers for their chronic dialysis patients requires exploration of a number of factors. These factors include the definition of a primary care provider, the time and expertise needed to provide primary care, the expectations of nephrologists and dialysis patients who give and receive primary care, the appropriate preventive care for end-stage renal disease (ESRD) patients, and the current and future roles of nephrologists within a changing health care environment. Unfortunately, few studies have addressed these issues, and there is little objective information on which to base guidelines and recommendations about nephrologist-directed primary care of ESRD patients. Most nephrologists spend a significant portion (30% to 35%) of their time caring for dialysis patients, and 90% report providing primary care to dialysis patients. Most dialysis patients view their nephrologist as their primary care provider. The increasingly aged and ill ESRD population will undoubtedly necessitate additional time and expertise for care from an understaffed nephrology work force. The increased use of advanced practice nurses and alliances with health care delivery systems under global capitation programs may develop into effective strategies to provide care for an increasing population of dialysis patients. The nonnephrologic health care needs, including specific and appropriate cancer screening and preventive health care protocols for ESRD patients whose life expectancies are significantly less than the general population, are unclear. The issues involved in considering nephrologists as primary caregivers for ESRD patients include these and other related factors, and will be discussed in this review. PMID:9531172

  8. A study to identify research issues in the area of electromagnetic measurements and signal handling of remotely sensed data

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Research issues in the area of electromagnetic measurements and signal handling of remotely sensed data are identified. The following seven issues are discussed; platform/sensor system position and velocity, platform/sensor attitudes and attitude rates, optics and antennas, detectors and associated electronics, sensor calibration, signal handling, and system design.

  9. 22 CFR 216.9 - Bilateral and multilateral studies and concise reviews of environmental issues.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... reviews of environmental issues. 216.9 Section 216.9 Foreign Relations AGENCY FOR INTERNATIONAL... environmental issues. Notwithstanding anything to the contrary in these procedures, the Administrator may... United States is a member or participant; or (b) Concise reviews of the environmental issues...

  10. 22 CFR 216.9 - Bilateral and multilateral studies and concise reviews of environmental issues.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... reviews of environmental issues. 216.9 Section 216.9 Foreign Relations AGENCY FOR INTERNATIONAL... environmental issues. Notwithstanding anything to the contrary in these procedures, the Administrator may... United States is a member or participant; or (b) Concise reviews of the environmental issues...

  11. 22 CFR 216.9 - Bilateral and multilateral studies and concise reviews of environmental issues.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... reviews of environmental issues. 216.9 Section 216.9 Foreign Relations AGENCY FOR INTERNATIONAL... environmental issues. Notwithstanding anything to the contrary in these procedures, the Administrator may... United States is a member or participant; or (b) Concise reviews of the environmental issues...

  12. Review of safety and mobility issues among older pedestrians.

    PubMed

    Tournier, Isabelle; Dommes, Aurélie; Cavallo, Viola

    2016-06-01

    Although old people make up an extremely vulnerable road-user group, older pedestrians' difficulties have been studied less extensively than those of older drivers, and more knowledge of this issue is still required. The present paper reviews current knowledge of older-adult problems with the main components of pedestrian activity, i.e., walking and obstacle negotiation, wayfinding, and road crossing. Compared to younger ones, old pedestrians exhibit declining walking skills, with a walking speed decrease, less stable balance, less efficient wayfinding strategies, and a greater number of unsafe road crossing behaviors. These difficulties are linked to age-related changes in sensorial, cognitive, physical, and self-perception abilities. It is now known that visual impairment, physical frailty, and attention deficits have a major negative impact on older pedestrians' safety and mobility, whereas the roles of self-evaluation and self-regulation are still poorly understood. All these elements must be taken into consideration, not only in developing effective safety interventions targeting older pedestrians, but also in designing roads and cars. Recent initiatives are presented here and some recommendations are proposed. PMID:26950033

  13. Review of a challenging clinical issue: Intrahepatic cholestasis of pregnancy

    PubMed Central

    Ozkan, Sebiha; Ceylan, Yasin; Ozkan, Orhan Veli; Yildirim, Sule

    2015-01-01

    Intrahepatic cholestasis of pregnancy (ICP) is a reversible pregnancy-specific cholestatic condition characterized by pruritus, elevated liver enzymes, and increased serum bile acids. It commences usually in the late second or third trimester, and quickly resolves after delivery. The incidence is higher in South American and Scandinavian countries (9.2%-15.6% and 1.5%, respectively) than in Europe (0.1%-0.2%). The etiology is multifactorial where genetic, endocrine, and environmental factors interact. Maternal outcome is usually benign, whereas fetal complications such as preterm labor, meconium staining, fetal distress, and sudden intrauterine fetal demise not infrequently lead to considerable perinatal morbidity and mortality. Ursodeoxycholic acid is shown to be the most efficient therapeutic agent with proven safety and efficacy. Management of ICP consists of careful monitoring of maternal hepatic function tests and serum bile acid levels in addition to the assessment of fetal well-being and timely delivery after completion of fetal pulmonary maturity. This review focuses on the current concepts about ICP based on recent literature data and presents an update regarding the diagnosis and management of this challenging issue. PMID:26109799

  14. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Procedures for issuing a decision on a registration review case. 155.58 Section 155.58 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures § 155.58 Procedures for issuing...

  15. 42 CFR 8.23 - Limitation on issues subject to review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Limitation on issues subject to review. 8.23 Section 8.23 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... Body § 8.23 Limitation on issues subject to review. The scope of review shall be limited to the...

  16. 42 CFR 8.23 - Limitation on issues subject to review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Limitation on issues subject to review. 8.23 Section 8.23 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... Body § 8.23 Limitation on issues subject to review. The scope of review shall be limited to the...

  17. Evolution as a Controversial Issue: A Review of Instructional Approaches

    ERIC Educational Resources Information Center

    Hermann, Ronald S.

    2008-01-01

    Although evolution has long been considered a controversial issue, little effort has been made to ensure that instructional approaches address the controversial nature of the issue. A framework for understanding the nature of controversy and some defining characteristics of controversial issues are provided. In light of this framework evolution is…

  18. Review of legal and institutional issues in the use of decentralized solar energy systems

    SciTech Connect

    Schweitzer, M.

    1980-04-01

    The legal and institutional issues involved in the use of decentralized solar energy systems are examined for the purpose of advising government planners and policymakers, the solar industry, solar researchers, and prospective solar users of present and potential impediments and incentives to solar commercialization. This information was gathered primarily through a comprehensive literature review, with supplementary data provided through interviews with representatives of organizations active in the solar field. Five major issue areas were identified in the course of this study: (1) prohibitions on the use of solar equipment, (2) regulation of the production and placement of solar systems, (3) access to sunlight, (4) financial incentives and impediments to the use of solar technologies, and (5) the public utility-solar user interface. Each can be important in its impacts on the incidence of solar usage. The major actors involved with the issues identified above represent both the private and public sectors. Important private sector participants include solar manufacturers and installers, labor unions, lending institutions, utility companies, solar users themselves, and other community property owners. In the public sector, local, state, and federal governments are all capable of acting in ways that can influence the solar commercialization effort. Implementation options are available for all levels of government seeking to take an active role in addressing the previously mentioned legal and institutional issues. The appropriate actions will vary from federal to state to local governments, but each level can be important in removing existing barriers and creating new incentives for solar use.

  19. Identifying the Discomfort: An Examination of Ethical Issues Encountered by MSW Students during Field Placement

    ERIC Educational Resources Information Center

    Dodd, Sarah-Jane

    2007-01-01

    The purpose of this descriptive study was to determine which ethical issues graduate social work students experienced most frequently during their field placement, the resources students used to resolve these issues, and whether such resources were helpful. The results indicate that conflicts concerning beneficence versus agency policy and…

  20. A review of the mental health issues of diabetes conference.

    PubMed

    Ducat, Lee; Rubenstein, Arthur; Philipson, Louis H; Anderson, Barbara J

    2015-02-01

    Individuals with type 1 diabetes are at increased risk for depression, anxiety disorder, and eating disorder diagnoses. People with type 1 diabetes are also at risk for subclinical levels of diabetes distress and anxiety. These mental/behavioral health comorbidities of diabetes are associated with poor adherence to treatment and poor glycemic control, thus increasing the risk for serious short- and long-term physical complications, which can result in blindness, amputations, stroke, cognitive decline, decreased quality of life, as well as premature death. When mental health comorbidities of diabetes are not diagnosed and treated, the financial cost to society and health care systems is catastrophic, and the human suffering that results is profound. This review summarizes state-of-the-art presentations and working group scholarly reports from the Mental Health Issues of Diabetes Conference (7-8 October 2013, Philadelphia, PA), which included stakeholders from the National Institutes of Health, people living with type 1 diabetes and their families, diabetes consumer advocacy groups, the insurance industry, as well as psychologists, psychiatrists, endocrinologists, and nurse practitioners who are all nationally and internationally recognized experts in type 1 diabetes research and care. At this landmark conference current evidence for the incidence and the consequences of mental health problems in type 1 diabetes was presented, supporting the integration of mental health screening and mental health care into routine diabetes medical care. Future research directions were recommended to establish the efficacy and cost-effectiveness of paradigms of diabetes care in which physical and mental health care are both priorities. PMID:25614689

  1. PETC Review. Issue 7, Winter 1992--1993

    SciTech Connect

    Santore, R.R.; Blaustein, B.D.; Friedman, S.; Reiss, J.; Brown, J.; Price, M.M.

    1993-02-01

    This issue of the PETC Review is devoted to explaining how the private sector can do business with DOE-and with PETC in particular-and how DOE works with academia, industry, and state and local groups to accomplish objectives of mutual interest. Over the past several years, the notion of ``cost-sharing`` has been receiving increased attention. Indeed, cost-shared RD&D is becoming the norm, not only within DOE but also among other government agencies, including the Department of Defense. It may surprise some of our readership to learn that RD&D cost-sharing is not a new government policy. In fact, it has been part of the DOE Acquisition Regulations from their inception in 1977. In lay terms, cost participation, a general kind of cost-sharing, is required for RD&D efforts in which the non-Federal participant`s goal is commercialization or in situations for which it is reasonable to expect that economic benefits will accrue to the participant as a result of the work. The policy is quite flexible and states that the degree of non-DOEcost participation depends on a number of factors, including the nature of the work performed and the extent of the project risk. As competition for RD&D funds increases, it is to be expected that cost-sharing requirements for development, and even for basic research, will increase. Nevertheless, we think that Federal support of RD&D will continue to be necessary to maintain this country`s leadership in science, technology, industry, and living standards.

  2. "Business Ethics Everywhere": An Experiential Exercise to Develop Students' Ability to Identify and Respond to Ethical Issues in Business

    ERIC Educational Resources Information Center

    Baker, Susan D.; Comer, Debra R.

    2012-01-01

    This article introduces an experiential exercise that enhances students' ability to identify ethical issues and to respond to them in ways that consider the relationship between organizational factors and ethical action. Students identify a required number of ethical incidents in their workplaces during a specified period. Students submit a…

  3. Identifying and removing duplicate records from systematic review searches

    PubMed Central

    Kwon, Yoojin; Lemieux, Michelle; McTavish, Jill; Wathen, Nadine

    2015-01-01

    Objective The purpose of this study was to compare effectiveness of different options for de-duplicating records retrieved from systematic review searches. Methods Using the records from a published systematic review, five de-duplication options were compared. The time taken to de-duplicate in each option and the number of false positives (were deleted but should not have been) and false negatives (should have been deleted but were not) were recorded. Results The time for each option varied. The number of positive and false duplicates returned from each option also varied greatly. Conclusion The authors recommend different de-duplication options based on the skill level of the searcher and the purpose of de-duplication efforts. PMID:26512216

  4. The full spectrum of ethical issues in the care of patients with ALS: a systematic qualitative review.

    PubMed

    Seitzer, F; Kahrass, H; Neitzke, G; Strech, D

    2016-02-01

    Dealing systematically with ethical issues in amyotrophic lateral sclerosis (ALS) care requires an unbiased awareness of all the relevant ethical issues. The aim of the study was to determine systematically and transparently the full spectrum of ethical issues in ALS care. We conducted a systematic review in Medline and Google Books (restricted to English and German literature published between 1993 and 2014). We applied qualitative text analysis and normative analysis to categorise the spectrum of ethical issues in ALS care. The literature review retrieved 56 references that together mentioned a spectrum of 103 ethical issues in ALS care. The spectrum was structured into six major categories that consist of first and second-order categories of ethical issues. The systematically derived spectrum of ethical issues in ALS care presented in this paper raises awareness and understanding of the complexity of ethical issues in ALS care. It also offers a basis for the systematic development of informational and training materials for health professionals, patients and their relatives, and society as a whole. Finally, it supports a rational and fair selection of all those ethical issues that should be addressed in health policies, position papers and clinical practice guidelines. Further research is needed to identify ways to systematically select the most relevant ethical issues not only in the clinical environment, but also for the development of clinical practice guidelines. PMID:26223806

  5. 36 CFR 216.8 - Availability of proposed Manual directives identified for formal public review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Manual directives identified for formal public review. 216.8 Section 216.8 Parks, Forests, and Public... SERVICE DIRECTIVES § 216.8 Availability of proposed Manual directives identified for formal public review. As a minimum, review copies of proposed Manual directives determined to be of substantial...

  6. Ethical Issues in Patient Safety Research: A Systematic Review of the Literature.

    PubMed

    Whicher, Danielle M; Kass, Nancy E; Audera-Lopez, Carmen; Butt, Mobasher; Jauregui, Iciar Larizgoitia; Harris, Kendra; Knoche, Jonathan; Saxena, Abha

    2015-09-01

    As many as 1 in 10 patients is harmed while receiving hospital care in wealthy countries. The risk of health care-associated infection in some developing countries is as much as 20 times higher. In response, in many global regions, increased attention has turned to the implementation of a broad program of safety research, encompassing a variety of methods. Although important international ethical guidelines for research exist, literature has been emerging in the last 20 years that begins to apply such guidelines to patient safety research specifically. This paper provides a review of the literature related to ethics, oversight, and patient safety research; identifies issues highlighted in articles as being of ethical relevance; describes areas of consensus regarding how to respond to these ethical issues; and highlights areas where additional ethical analysis and discussion are needed to provide guidance to those in the field. PMID:24618642

  7. IDENTIFYING RECRUITMENT AND RETENTION ISSUES AMONG NON-WHITE PARTICIPANTS FOR THE NATIONAL CHILDREN'S STUDY

    EPA Science Inventory

    Understanding potential stakeholders perspectives prior to recruitment may improve the effectiveness of a recruitment campaign as well as sustain participant retention. In early 2003, eighteen focus groups were conducted across the United States to address these issues, but non-...

  8. Review of performance, medical, and operational data on pilot aging issues

    NASA Technical Reports Server (NTRS)

    Stoklosa, J. H.

    1992-01-01

    An extensive review of the literature and studies relating to performance, medical, operational, and legal data regarding pilot aging issues was performed in order to determine what evidence there is, if any, to support mandatory pilot retirement. Popular misconceptions about aging, including the failure to distinguish between the normal aging process and disease processes that occur more frequently in older individuals, continue to contribute to much of the misunderstanding and controversy that surround this issue. Results: Review of medical data related to the pilot aging issue indicate that recent improvement in medical diagnostics and treatment technology have made it possible to identify to a high degree individuals who are at risk for developing sudden incapacitating illness and for treating those with disqualifying medical conditions. Performance studies revealed that after controlling for the presence of disease states, older pilots are able to perform as well as younger pilots on many performance tasks. Review of accident data showed that older, healthy pilots do not have higher accident rates than younger pilots, and indeeed, evidence suggests that older pilots have an advantage in the cockpit due to higher experience levels. The Man-Machine-Mission-Environment interface of factors can be managed through structured, supervised, and enhanced operations, maintenance, flight reviews, and safety procedures in order to ensure safe and productive operations by reducing the margin of error and by increasing the margin of safety. Conclusions: There is no evidence indicating any specific age as an arbitrary cut-off point for pilots to perform their fight duties. A combination of regular medical screening, performance evaluation, enhanced operational maintenance, and safety procedures can most effectively ensure a safe pilot population than can a mandatory retirement policy based on arbitrary age restrictions.

  9. A Review Approaches to Identify Enteric Bacterial Pathogens

    PubMed Central

    Amani, Jafar; Mirhosseini, Seyed Ali; Imani Fooladi, Abbas Ali

    2014-01-01

    Context: Diarrhea is a common disease across the world. According to WHO, every year about two billion cases of diarrhea are reported in the world. It occurs mainly in the tropical regions and is a main cause of morbidity and mortality, particularly in young children and adults. Evidence Acquisition: One of the major causes of diarrheal diseases is bacteria; detection of pathogenic bacteria is a global key to the prevention and identification of food-borne diseases and enteric infections (like diarrhea). Conclusions: Therefore, development of rapid diagnostic methods with suitable sensitivity and specificity is very important about this infectious disease. In this review, we will discuss some of the important diagnostic methods. PMID:25793091

  10. Open-system dynamics of entanglement: a key issues review.

    PubMed

    Aolita, Leandro; de Melo, Fernando; Davidovich, Luiz

    2015-04-01

    One of the greatest challenges in the fields of quantum information processing and quantum technologies is the detailed coherent control over each and every constituent of quantum systems with an ever increasing number of particles. Within this endeavor, harnessing of many-body entanglement against the detrimental effects of the environment is a major pressing issue. Besides being an important concept from a fundamental standpoint, entanglement has been recognized as a crucial resource for quantum speed-ups or performance enhancements over classical methods. Understanding and controlling many-body entanglement in open systems may have strong implications in quantum computing, quantum simulations of many-body systems, secure quantum communication or cryptography, quantum metrology, our understanding of the quantum-to-classical transition, and other important questions of quantum foundations.In this paper we present an overview of recent theoretical and experimental efforts to underpin the dynamics of entanglement under the influence of noise. Entanglement is thus taken as a dynamic quantity on its own, and we survey how it evolves due to the unavoidable interaction of the entangled system with its surroundings. We analyze several scenarios, corresponding to different families of states and environments, which render a very rich diversity of dynamical behaviors.In contrast to single-particle quantities, like populations and coherences, which typically vanish only asymptotically in time, entanglement may disappear at a finite time. In addition, important classes of entanglement display an exponential decay with the number of particles when subject to local noise, which poses yet another threat to the already-challenging scaling of quantum technologies. Other classes, however, turn out to be extremely robust against local noise. Theoretical results and recent experiments regarding the difference between local and global decoherence are summarized. Control and

  11. Evaluation of speech errors in Putonghua speakers with cleft palate: a critical review of methodology issues.

    PubMed

    Jiang, Chenghui; Whitehill, Tara L

    2014-04-01

    Speech errors associated with cleft palate are well established for English and several other Indo-European languages. Few articles describing the speech of Putonghua (standard Mandarin Chinese) speakers with cleft palate have been published in English language journals. Although methodological guidelines have been published for the perceptual speech evaluation of individuals with cleft palate, there has been no critical review of methodological issues in studies of Putonghua speakers with cleft palate. A literature search was conducted to identify relevant studies published over the past 30 years in Chinese language journals. Only studies incorporating perceptual analysis of speech were included. Thirty-seven articles which met inclusion criteria were analyzed and coded on a number of methodological variables. Reliability was established by having all variables recoded for all studies. This critical review identified many methodological issues. These design flaws make it difficult to draw reliable conclusions about characteristic speech errors in this group of speakers. Specific recommendations are made to improve the reliability and validity of future studies, as well to facilitate cross-center comparisons. PMID:24093158

  12. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures... pesticide's registration review docket the Agency's proposed decision and the bases for the decision. There... standard for registration and describe the basis for such proposed findings. (2) Identify proposed...

  13. Identifying experimental surrogates for Bacillus anthracis spores: a review

    PubMed Central

    2010-01-01

    Bacillus anthracis, the causative agent of anthrax, is a proven biological weapon. In order to study this threat, a number of experimental surrogates have been used over the past 70 years. However, not all surrogates are appropriate for B. anthracis, especially when investigating transport, fate and survival. Although B. atrophaeus has been widely used as a B. anthracis surrogate, the two species do not always behave identically in transport and survival models. Therefore, we devised a scheme to identify a more appropriate surrogate for B. anthracis. Our selection criteria included risk of use (pathogenicity), phylogenetic relationship, morphology and comparative survivability when challenged with biocides. Although our knowledge of certain parameters remains incomplete, especially with regards to comparisons of spore longevity under natural conditions, we found that B. thuringiensis provided the best overall fit as a non-pathogenic surrogate for B. anthracis. Thus, we suggest focusing on this surrogate in future experiments of spore fate and transport modelling. PMID:21092338

  14. 10 CFR Appendix Q to Part 50 - Pre-Application Early Review of Site Suitability Issues

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Pre-Application Early Review of Site Suitability Issues Q Appendix Q to Part 50 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Pt. 50, App. Q Appendix Q to Part 50—Pre-Application Early Review of Site Suitability Issues...

  15. 10 CFR Appendix Q to Part 50 - Pre-Application Early Review of Site Suitability Issues

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Pre-Application Early Review of Site Suitability Issues Q Appendix Q to Part 50 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Pt. 50, App. Q Appendix Q to Part 50—Pre-Application Early Review of Site Suitability Issues This appendix sets out procedures...

  16. Lessons from Adult Education: Identifying and Exploring Emerging Ethical Issues in Technologically Enhanced Performance

    ERIC Educational Resources Information Center

    Mabry, Christie Knittel; O'Driscoll, Tony

    2003-01-01

    Technologically Enhanced Performance (TEP) is the application of technology to improve the performance of knowledge workers. TEP is both an intellectual and ideological complement to the field of Adult Education. As such, much can be learned about ethical issues associated with implementing TEP from the established research and literature base in…

  17. Contemporary Civil Rights Challenges of "Brown vs. Board of Education": School Leaders Identify Current Issues

    ERIC Educational Resources Information Center

    Scott, Bradley

    2004-01-01

    School leaders from five states gathered recently to examine civil rights issues facing students today. The session was held by the Intercultural Development Research Association (IDRA) South Central Collaborative for Equity, which is the federally-funded equity assistance center for Arkansas, Louisiana, New Mexico, Oklahoma and Texas. The…

  18. Thirty-Five Years of Transition Topics: A Review of CDTEI Issues from 1978 to 2012

    ERIC Educational Resources Information Center

    Madaus, Joseph W.; Gelbar, Nicholas W.; Dukes, Lyman L., III; Faggella-Luby, Michael; Lalor, Adam R.; Kowitt, Jennifer S.

    2013-01-01

    A systematic review was conducted of 581 articles published in 76 issues of "Career Development and Transition for Exceptional Individuals" from the journal's initial issue in 1978 to the final issue of its 35th year in 2012. Articles were coded based on inclusion of original or secondary data and if not, what type of information…

  19. Identifying Educationally Influential Specialists: Issues Arising from the Use of "Classic" Criteria

    ERIC Educational Resources Information Center

    Wright, Frances C.; Ryan, David P.; Dodge, Jason E.; Last, Linda D.; Law, Calvin H. L.; Smith, Andrew J.

    2004-01-01

    Introduction: Educationally influential physicians (EIPs) are identified by their colleagues as people who (1) encourage learning and enjoy sharing their knowledge, (2) are clinical experts and always seem up to date, and (3) treat others as equals. We aimed to identify surgical and pathologist EIPs for colorectal cancer (CRC) in Ontario as part…

  20. Science and technology review, July-August 1998 issue

    SciTech Connect

    Smart, J

    1998-07-01

    On the occasion of Edward Teller's 90th birthday, S&TR has the pleasure of honoring Lawrence Livermore's co-founder and most influential scientist. Teller is known for his inventive work in physics, his concepts leading to thermonuclear explosions, and his strong stands on such issues as science education, the nation's strategic defense, the needs for science in the future, and sharing scientific information. The articles in this issue also show him, as always, tirelessly moving forward with his new and changing interests.

  1. Environmental Mass Spectrometry: Emerging Contaminants and Current Issues (2010 Review)

    EPA Science Inventory

    This biennial review covers developments in environmental mass spectrometry for emerging environmental contaminants over the period of 2008-2009. A few significant references that appeared between January and February 2010 are also included. Analytical Chemistry’s current polic...

  2. Corporal Punishment in American Schools: A Review of the Issues.

    ERIC Educational Resources Information Center

    Hess, Fritz

    1985-01-01

    Outlines the history of corporal punishment in American schools and the development of the debate on its application in the schools. Reviews court decisions since the 1970s that affect the controversy. Includes a list of references. (MD)

  3. Predicting Adolescent Drug Abuse: A Review of Issues, Methods and Correlates. Research Issues 11.

    ERIC Educational Resources Information Center

    Lettieri, Dan J., Ed.

    Presented are 18 papers on predicting adolescent drug abuse. The papers have the following titles: "Current Issues in the Epidemiology of Drug Abuse as Related to Psychosocial Studies of Adolescent Drug Use"; "The Quest for Interpersonal Predictors of Marihuana Abuse in Adolescents"; "Assessing the Interpersonal Determinants of Adolescent Drug…

  4. Ethical issues in autologous stem cell transplantation (ASCT) in advanced breast cancer: A systematic literature review

    PubMed Central

    2011-01-01

    Background An effectiveness assessment on ASCT in locally advanced and metastatic breast cancer identified serious ethical issues associated with this intervention. Our objective was to systematically review these aspects by means of a literature analysis. Methods We chose the reflexive Socratic approach as the review method using Hofmann's question list, conducted a comprehensive literature search in biomedical, psychological and ethics bibliographic databases and screened the resulting hits in a 2-step selection process. Relevant arguments were assembled from the included articles, and were assessed and assigned to the question list. Hofmann's questions were addressed by synthesizing these arguments. Results Of the identified 879 documents 102 included arguments related to one or more questions from Hofmann's question list. The most important ethical issues were the implementation of ASCT in clinical practice on the basis of phase-II trials in the 1990s and the publication of falsified data in the first randomized controlled trials (Bezwoda fraud), which caused significant negative effects on recruiting patients for further clinical trials and the doctor-patient relationship. Recent meta-analyses report a marginal effect in prolonging disease-free survival, accompanied by severe harms, including death. ASCT in breast cancer remains a stigmatized technology. Reported health-related-quality-of-life data are often at high risk of bias in favor of the survivors. Furthermore little attention has been paid to those patients who were dying. Conclusions The questions were addressed in different degrees of completeness. All arguments were assignable to the questions. The central ethical dimensions of ASCT could be discussed by reviewing the published literature. PMID:21496244

  5. Review of Issues Facing Congress. News from Capitol Hill.

    ERIC Educational Resources Information Center

    Heinz, Ann Simeo

    2001-01-01

    Discusses various topics that have faced the 107th U.S. Congress, such as tax cuts, judicial appointments, domestic issues, patients' bill of rights, stem cell research, election law, and campaign finance reform. Includes information on U.S. Senate and federal judicial appointments. Provides ideas for student learning activities. (CMK)

  6. International Review of Staff Appraisal Practices: Current Trends and Issues

    ERIC Educational Resources Information Center

    Williams, Richard; And Others

    1977-01-01

    Describes the purposes, form, and content of staff appraisal schemes in ten countries' public administrations and discusses a number of related trends and issues. Examines the effects of these trends in light of the organizations' experiences and draws attention to the inadequate monitoring and evaluation of staff appraisal schemes. (Author/JG)

  7. Review of Congressional Issues. News from Capitol Hill.

    ERIC Educational Resources Information Center

    Heinz, Ann Simeo

    2002-01-01

    Focuses on U.S. congressional issues in two categories: (1) enacted legislation, and (2) proposed legislation. Addresses topics such as the resolution related to Iraq, the Department of Homeland Security, Pledge of Allegiance, social security protection, elder justice, and women's rights. Includes learning activities. (CMK)

  8. A screening approach for identifying environmental justice issues in environmental impact statements

    SciTech Connect

    Schexnayder, S.S.

    1995-12-01

    Executive Order 12898 and the accompanying memorandum addressed to Federal agency heads, both issued on February 11, 1994, require NEPA processes to incorporate environmental justice. The NEPA processes affected are: (1) public involvement formats, (2) analyses of potential impacts. The Executive Order clearly indicates that research strategies and mitigation measure should be developed with the input of the populations mentioned in the Executive Order, i.e., minority and low-income populations. However, an enhanced public involvement process may not occur because the NEPA activity may have been underway before the Executive Order was issued or because the agency chooses not to change traditional public participation mechanisms. It is also possible that enhanced mechanisms may not effectively elicit involvement. In either case, analysis that considers environmental justice must proceed. These analyses could be highly data-intensive--requiring new or modified methodological approaches-- and time-intensive, particularly if the process elements of the executive order are interpreted broadly, Federal agencies and NEPA project managers already have expressed concern about the potential cost of conducting exhaustive environmental justice related analyses where they may not be warranted. Also, the time and resources required to conduct a full environmental justice analysis is counter to recent trends to streamline the NEPA process. In light of this, a process to screen for indicators of the potential for environmental justice issues has been developed. The method incorporates separate screens for human health impacts, socioeconomic impacts, and social structural impacts. Positive results of any screen indicates the need for full-scale, environmental-justice-related analysis of that category of impact. The screen is intended as a useful tool in implementing environmental justice in environmental impact statements.

  9. Usability Evaluation Survey for Identifying Design Issues in Civil Flight Deck

    NASA Astrophysics Data System (ADS)

    Ozve Aminian, Negin; Izzuddin Romli, Fairuz; Wiriadidjaja, Surjatin

    2016-02-01

    Ergonomics assessment for cockpit in civil aircraft is important as the pilots spend most of their time during flight on the seating posture imposed by its design. The improper seat design can cause discomfort and pain, which will disturb the pilot's concentration in flight. From a conducted survey, it is found that there are some issues regarding the current cockpit design. This study aims to highlight potential mismatches between the current cockpit design and the ergonomic design recommendations for anthropometric dimensions and seat design, which could be the roots of the problems faced by the pilots in the cockpit.

  10. 25 CFR 170.501 - What happens when the review process identifies areas for improvement?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What happens when the review process identifies areas for... WATER INDIAN RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads Program Facilities Program Reviews and Management Systems § 170.501 What happens when the review...

  11. 25 CFR 170.501 - What happens when the review process identifies areas for improvement?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What happens when the review process identifies areas for... WATER INDIAN RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads Program Facilities Program Reviews and Management Systems § 170.501 What happens when the review...

  12. 25 CFR 170.501 - What happens when the review process identifies areas for improvement?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What happens when the review process identifies areas for... WATER INDIAN RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads Program Facilities Program Reviews and Management Systems § 170.501 What happens when the review...

  13. 25 CFR 170.501 - What happens when the review process identifies areas for improvement?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What happens when the review process identifies areas for... WATER INDIAN RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads Program Facilities Program Reviews and Management Systems § 170.501 What happens when the review...

  14. 25 CFR 170.501 - What happens when the review process identifies areas for improvement?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What happens when the review process identifies areas for... WATER INDIAN RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads Program Facilities Program Reviews and Management Systems § 170.501 What happens when the review...

  15. Licensing of spent fuel dry storage and consolidated rod storage: A Review of Issues and Experiences

    SciTech Connect

    Bailey, W.J.

    1990-02-01

    The results of this study, performed by Pacific Northwest Laboratory (PNL) and sponsored by the US Department of Energy (DOE), respond to the nuclear industry's recommendation that a report be prepared that collects and describes the licensing issues (and their resolutions) that confront a new applicant requesting approval from the US Nuclear Regulatory Commission (NRC) for dry storage of spent fuel or for large-scale storage of consolidated spent fuel rods in pools. The issues are identified in comments, questions, and requests from the NRC during its review of applicants' submittals. Included in the report are discussions of (1) the 18 topical reports on cask and module designs for dry storage fuel that have been submitted to the NRC, (2) the three license applications for dry storage of spent fuel at independent spent fuel storage installations (ISFSIs) that have been submitted to the NRC, and (3) the three applications (one of which was later withdrawn) for large-scale storage of consolidated fuel rods in existing spent fuel storage pools at reactors that were submitted tot he NRC. For each of the applications submitted, examples of some of the issues (and suggestions for their resolutions) are described. The issues and their resolutions are also covered in detail in an example in each of the three subject areas: (1) the application for the CASTOR V/21 dry spent fuel storage cask, (2) the application for the ISFSI for dry storage of spent fuel at Surry, and (3) the application for full-scale wet storage of consolidated spent fuel at Millstone-2. The conclusions in the report include examples of major issues that applicants have encountered. Recommendations for future applicants to follow are listed. 401 refs., 26 tabs.

  16. A review of occupational safety and health issues relevant to the environmental restoration program: Selected case histories and associated issues

    SciTech Connect

    Lesperance, A.M.; Siegel, M.R.; McKinney, M.D.

    1992-10-01

    This report describes a study conducted by Pacific Northwest Laboratory (PNL) to determine the impact of occupational safety and health (OSH) issues on the environmental restoration process at US Department of Energy sites. PNL selected three remediation projects to study: (1) the 618-9 Burial Ground Expedited Removal Action at the Hanford Site, (2) the Chemical Consolidation Interim Response Action at the Weldon Spring Site, (3) and the 200 West Area Carbon Tetrachloride Expedited Removal Action and VOC-Arid Integration Demonstration at the Hanford Site. The first two case studies involve sites where a remediation activity has been complete. The third case study involves a remediation activity in its early stages of development. This study identifies OSH issues related to actual cleanup, time, documentation, training, and technology development. These issues need to be considered by DOE before making long-term planning efforts. Section 4.0 of this report describes recommendations for addressing these issues.

  17. Organisational Issues for E-Learning: Critical Success Factors as Identified by HE Practitioners

    ERIC Educational Resources Information Center

    McPherson, Maggie; Nunes, Miguel Baptista

    2006-01-01

    Purpose: The purpose of this paper is to report on a research project that identified organisational critical success factors (CSFs) for e-learning implementation in higher education (HE). These CSFs can be used as a theoretical foundation upon which to base decision-making and strategic thinking about e-learning. Design/methodology/approach: The…

  18. Key Issues in Empirically Identifying Chronically Low-Performing and Turnaround Schools

    ERIC Educational Resources Information Center

    Hansen, Michael

    2012-01-01

    One of the US Department of Education's key priorities is turning around the nation's persistently low-achieving schools, yet exactly how to identify low-performing schools is a task left to state policy makers, and a myriad of definitions have been utilized. In addition, exactly how to recognize when a school begins to turn around is not well…

  19. Speaking for America's Children: Child Advocates Identify Children's Issues and 2002 State Priorities.

    ERIC Educational Resources Information Center

    Foster, Catherine Crystal

    Despite the ongoing devolution of policymaking from the federal to the state and local level, there remains a belief that there is a single agenda for children. In summer 2001, the National Association of Child Advocates (NACA) surveyed its membership to determine if a national agenda for children exists. This paper identifies the key issues…

  20. 'Peer review' for scientific manuscripts: Emerging issues, potential threats, and possible remedies.

    PubMed

    Das, A K

    2016-04-01

    Reviewers play a vital role in ensuring quality control of scientific manuscripts published in any journal. The traditional double blind peer review, although a time-tested method, has come under increasing criticism in the face of emerging trends in the review process with the primary concern being the delays in completion of the review process. Other issues are the inability to detect errors/fraud, lack of transparency, lack of reliability, potential for bias, potential for unethical practices, lack of objectivity, inconsistencies amongst reviewers, lack of recognition and motivation of reviewers. Alternative options to classical peer review being propagated are: open review, immediate self-publication using preprint servers, nonselective review focusing primarily on the scientific content, and post-publication review. These alternative review processes, however, may suffer from the inability to validate quality control. In addition, anecdotal instances of peer review frauds are being reported more often than earlier. Suggested means to ensure quality of peer review process includes:(a) each journal to have its own database of reviewers, (b) verification of email IDs of reviewers provided by authors along with details of their institutions, (c) ensure credibility of reviewers before requesting for review, (d) check for plagiarism at the editorial level, (e) editors to distinguish between a good review from a possible biased/bad review, and (f) give recognition for reviewers once in a year. To conclude, quickness of review and publication should not dictate the scientific publication process at the cost of quality of contents. PMID:27257328

  1. Emerging issues on comprehensive hemophilia care: preventing, identifying, and monitoring age-related comorbidities.

    PubMed

    Coppola, Antonio; Santoro, Cristina; Franchini, Massimo; Mannucci, Caterina; Mogavero, Selene; Molinari, Angelo Claudio; Schinco, Piercarla; Tagliaferri, Annarita; Santoro, Rita Carlotta

    2013-10-01

    Life expectancy for persons with hemophilia (PWH) has considerably increased in the last decades as a direct result of the availability of modern therapies to control the clotting defect. Because their life expectancy now matches that of the general population, PWH are experiencing age-related comorbidities, such as, cardiovascular diseases, metabolic syndrome, renal diseases, sexuality issues, malignancies, and neurologic problems, that until recently have been rarely seen in this group of patients. In this article, we present a summary of the current knowledge on the aging PWH along with the clinical approaches that may be integrated into the routine comprehensive care of these patients for preventing, diagnosing, and monitoring age-related comorbidities. In general, patients with and without hemophilia should receive similar care, with close collaboration between the physician treating PWH and the specialty expert treating the comorbid disease. PMID:24014070

  2. Water Analysis: Emerging Contaminants and Current Issues (2009 Review)

    EPA Science Inventory

    This biennial review covers developments in Water Analysis for Emerging Environmental Contaminants over the period of 2007-2008. A few significant references that appeared between January and February 2009 are also included. Analytical Chemistry’s current policy is to limit rev...

  3. Review of the Literature on Asian American Mental Health Issues.

    ERIC Educational Resources Information Center

    Le, Trang Ngoc

    Within the mental health treatment field there is an underutilization of services by Asian Americans. Researchers have questioned how to lessen the gap between the number of Asian Americans who need mental health services and the significantly lower number who successfully use these services. A review of current research points out that matching…

  4. An Index to the Caricatures in the "New York Review of Books" from Its Inception Through the Fifteenth Anniversary Issue (1963-1978).

    ERIC Educational Resources Information Center

    Drazan, Joseph Gerald; Sanguine, Phyllis

    This index identifies caricatures drawn by David Levine which are found in the "New York Review of Books" from its first issue in 1963 through the special fifteenth anniversary issue dated October 12, 1978. The index is arranged alphabetically by surname for each personality caricatured, with some cross references. The numbering system used refers…

  5. Electronic cigarettes: a review of safety and clinical issues.

    PubMed

    Weaver, Michael; Breland, Alison; Spindle, Tory; Eissenberg, Thomas

    2014-01-01

    This clinical case conference discusses 3 cases of patients using electronic cigarettes. Electronic cigarettes, also referred to as electronic nicotine delivery systems or "e-cigarettes," generally consist of a power source (usually a battery) and a heating element (commonly referred to as an atomizer) that vaporize a solution (e-liquid). The user inhales the resulting vapor. E-liquids contain humectants such as propylene glycol and/or vegetable glycerin, flavorings, and usually, but not always, nicotine. Each patient's information is an amalgamation of actual patients and is presented and then followed by a discussion of clinical issues. PMID:25089953

  6. High-power FEL design issues - a critical review

    SciTech Connect

    Litvinenko, V.N.; Madey, J.M.J.; O`Shea, P.G.

    1995-12-31

    The high-average power capability of FELs has been much advertised but little realized. In this paper we provide a critical analysis of the technological and economic issues associated with high-average power FEL operation from the UV to near IR. The project of IR FEL for the Siberian Center of photochemical researches is described. The distinguished features of this project are the use of the race-track microtron-recuperator and the {open_quotes}electron output of radiation{close_quotes}. The building for the machine is under reconstruction now. About half of hardware has been manufactured. The assembly of installation began.

  7. Issues in benchmarking human reliability analysis methods : a literature review.

    SciTech Connect

    Lois, Erasmia; Forester, John Alan; Tran, Tuan Q.; Hendrickson, Stacey M. Langfitt; Boring, Ronald L.

    2008-04-01

    There is a diversity of human reliability analysis (HRA) methods available for use in assessing human performance within probabilistic risk assessment (PRA). Due to the significant differences in the methods, including the scope, approach, and underlying models, there is a need for an empirical comparison investigating the validity and reliability of the methods. To accomplish this empirical comparison, a benchmarking study is currently underway that compares HRA methods with each other and against operator performance in simulator studies. In order to account for as many effects as possible in the construction of this benchmarking study, a literature review was conducted, reviewing past benchmarking studies in the areas of psychology and risk assessment. A number of lessons learned through these studies are presented in order to aid in the design of future HRA benchmarking endeavors.

  8. Issues in Benchmarking Human Reliability Analysis Methods: A Literature Review

    SciTech Connect

    Ronald L. Boring; Stacey M. L. Hendrickson; John A. Forester; Tuan Q. Tran; Erasmia Lois

    2010-06-01

    There is a diversity of human reliability analysis (HRA) methods available for use in assessing human performance within probabilistic risk assessments (PRA). Due to the significant differences in the methods, including the scope, approach, and underlying models, there is a need for an empirical comparison investigating the validity and reliability of the methods. To accomplish this empirical comparison, a benchmarking study comparing and evaluating HRA methods in assessing operator performance in simulator experiments is currently underway. In order to account for as many effects as possible in the construction of this benchmarking study, a literature review was conducted, reviewing past benchmarking studies in the areas of psychology and risk assessment. A number of lessons learned through these studies are presented in order to aid in the design of future HRA benchmarking endeavors.

  9. Review of Issues Associated with Safe Operation and Management of the Space Shuttle Program

    NASA Technical Reports Server (NTRS)

    Johnstone, Paul M.; Blomberg, Richard D.; Gleghorn, George J.; Krone, Norris J.; Voltz, Richard A.; Dunn, Robert F.; Donlan, Charles J.; Kauderer, Bernard M.; Brill, Yvonne C.; Englar, Kenneth G.; Himmel, Seymour C.; Fitch, Dennis E.; Parmet, Norman R.; McDonald, John F.McDonald; Stewart, John G.

    1996-01-01

    At the request of the President of the United States through the Office of Science and Technology Policy (OSTP), the NASA Administrator tasked the Aerospace Safety Advisory Panel with the responsibility to identify and review issues associated with the safe operation and management of the Space Shuttle program arising from ongoing efforts to improve and streamline operations. These efforts include the consolidation of operations under a single Space Flight Operations Contract (SFOC), downsizing the Space Shuttle workforce and reducing costs of operations and management. The Panel formed five teams to address the potentially significant safety impacts of the seven specific topic areas listed in the study Terms of Reference. These areas were (in the order in which they are presented in this report): Maintenance of independent safety oversight; implementation plan for the transition of Shuttle program management to the Lead Center; communications among NASA Centers and Headquarters; transition plan for downsizing to anticipated workforce levels; implementation of a phased transition to a prime contractor for operations; Shuttle flight rate for Space Station assembly; and planned safety and performance upgrades for Space Station assembly. The study teams collected information through briefings, interviews, telephone conversations and from reviewing applicable documentation. These inputs were distilled by each team into observations and recommendations which were then reviewed by the entire Panel.

  10. Review and Prioritization of Technical Issues Related to Burnup Credit for LWR Fuel

    SciTech Connect

    Parks, C V; DeHart, M D; Wagner, John C

    2000-03-13

    This report has been prepared to review relevant background information and provide technical discussion that will help initiate a PIRT (Phenomena Identification and Ranking Tables) process for use of burnup credit in light-water reactor (LWR) spent fuel storage and transport cask applications. The PIRT process will be used by the NRC Office of Nuclear Regulatory Research to help prioritize and guide a coordinated program of research and as a means to obtain input/feedback from industry and other interested parties. The review and discussion in this report are based on knowledge and experience gained from work performed in the United States and other countries. Current regulatory practice and perceived industry needs are also reviewed as a background for prioritizing technical needs that will facilitate safe practice in the use of burnup credit. Relevant physics and analysis phenomenon are identified, and an assessment of their importance to burnup credit implementation is given. Finally, phenomena that need to be better understood for effective licensing, together with technical issues that require resolution, are presented and discussed in the form of a prioritization ranking and initial draft program plan.

  11. Identifying Key Issues and Potential Solutions for Integrated Arrival, Departure, Surface Operations by Surveying Stakeholder Preferences

    NASA Technical Reports Server (NTRS)

    Aponso, Bimal; Coppenbarger, Richard A.; Jung, Yoon; Quon, Leighton; Lohr, Gary; O’Connor, Neil; Engelland, Shawn

    2015-01-01

    NASA's Aeronautics Research Mission Directorate (ARMD) collaborates with the FAA and industry to provide concepts and technologies that enhance the transition to the next-generation air-traffic management system (NextGen). To facilitate this collaboration, ARMD has a series of Airspace Technology Demonstration (ATD) sub-projects that develop, demonstrate, and transitions NASA technologies and concepts for implementation in the National Airspace System (NAS). The second of these sub-projects, ATD-2, is focused on the potential benefits to NAS stakeholders of integrated arrival, departure, surface (IADS) operations. To determine the project objectives and assess the benefits of a potential solution, NASA surveyed NAS stakeholders to understand the existing issues in arrival, departure, and surface operations, and the perceived benefits of better integrating these operations. NASA surveyed a broad cross-section of stakeholders representing the airlines, airports, air-navigation service providers, and industry providers of NAS tools. The survey indicated that improving the predictability of flight times (schedules) could improve efficiency in arrival, departure, and surface operations. Stakeholders also mentioned the need for better strategic and tactical information on traffic constraints as well as better information sharing and a coupled collaborative planning process that allows stakeholders to coordinate IADS operations. To assess the impact of a potential solution, NASA sketched an initial departure scheduling concept and assessed its viability by surveying a select group of stakeholders for a second time. The objective of the departure scheduler was to enable flights to move continuously from gate to cruise with minimal interruption in a busy metroplex airspace environment using strategic and tactical scheduling enhanced by collaborative planning between airlines and service providers. The stakeholders agreed that this departure concept could improve schedule

  12. Kosterlitz-Thouless physics: a review of key issues

    NASA Astrophysics Data System (ADS)

    Kosterlitz, J. Michael

    2016-02-01

    This article reviews, from a very personal point of view, the origins and the early work on transitions driven by topological defects such as vortices in the two dimensional planar rotor model and in 4Helium films and dislocations and disclinations in 2D crystals. I cover the early papers with David Thouless and describe the important insights but also the errors and oversights since corrected by other workers. I then describe some of the experimental verifications of the theory and some numerical simulations. Finally applications to superconducting arrays of Josephson junctions and to recent cold atom experiments are described.

  13. [MODERN ISSUES OF PUBLIC HEALTH:THE REVIEW].

    PubMed

    Mamyrbaev, A; Umarova, G

    2016-05-01

    The purpose of this review is the study of literature for the development of effective public health programs. The overall health of the population depends on complex of social and biological factors of the environment, which is measured by demographic indices, physical development, morbidity, disability and socioeconomic characteristics. Key health data, socioeconomic and demographic statistics of the region are presented. The complex tools necessary to answer the public health requirements of residents in a certain area are recommended. Monitoring of health and demographic situation is urgent, because it makes it possible to adjust the basis of social, ecological and economic processes in the given area. PMID:27348170

  14. Driving and Epilepsy: a Review of Important Issues.

    PubMed

    Kang, Joon Y; Mintzer, Scott

    2016-09-01

    Driving restrictions in people with epilepsy (PWE) is a highly contentious topic. The fundamental difficulty lies in achieving a balance between safety and practicality. The aim of this review is to provide an overview, history, and rationale behind current laws regarding driving restriction in PWE. We also discuss recent findings that may be helpful to practitioners during individual discussions with PWE including seizure recurrence risk after first seizure, recurrent seizure, and anticonvulsant with drawl and driving restrictions in patients with psychogenic non-epileptic seizures (PNES). PMID:27443647

  15. A Review on Potential Issues and Challenges in MR Imaging

    PubMed Central

    Kanakaraj, Jagannathan

    2013-01-01

    Magnetic resonance imaging is a noninvasive technique that has been developed for its excellent depiction of soft tissue contrasts. Instruments capable of ultra-high field strengths, ≥7 Tesla, were recently engineered and have resulted in higher signal-to-noise and higher resolution images. This paper presents various subsystems of the MR imaging systems like the magnet subsystem, gradient subsystem, and also various issues which arise due to the magnet. Further, it also portrays finer details about the RF coils and transceiver and also various limitations of the RF coils and transceiver. Moreover, the concept behind the data processing system and the challenges related to it were also depicted. Finally, the various artifacts associated with the MR imaging were clearly pointed out. It also presents a brief overview about all the challenges related to MR imaging systems. PMID:24381523

  16. Ethical issues in artificial nutrition and hydration: a review.

    PubMed

    Geppert, Cynthia M A; Andrews, Maria R; Druyan, Mary Ellen

    2010-01-01

    Healthcare professionals often face clinical and ethical challenges when charged with making decisions related to provision or lack of provision of artificial nutrition and hydration. The intent of this review is to supply a framework of clinical practices, ethical principles, legal precedents, and professional guidelines that will impart information and can assist decision making regarding artificial nutrition and hydration. Comprehensive understanding of the theory and practice of informed consent for competent adults, decisionally incompetent adults, and minors is necessary for making valid clinical judgments and for guiding patients and their families or surrogates in choosing options related to initiating, withholding, or withdrawing artificial nutrition and hydration. The framework offered in this review can serve as a basis for evaluation of appropriateness of artificial nutrition and hydration in 3 common conditions in which decision making is particularly challenging: terminal illness, advanced dementia, and a persistent vegetative state. The framework facilitates guidance for institutional policy makers and individual nutrition support professionals dealing with situations in which personal values often create ethical dilemmas related to artificial nutrition and hydration and its utility. PMID:19897766

  17. Superconductor digital electronics: Scalability and energy efficiency issues (Review Article)

    NASA Astrophysics Data System (ADS)

    Tolpygo, Sergey K.

    2016-05-01

    Superconductor digital electronics using Josephson junctions as ultrafast switches and magnetic-flux encoding of information was proposed over 30 years ago as a sub-terahertz clock frequency alternative to semiconductor electronics based on complementary metal-oxide-semiconductor (CMOS) transistors. Recently, interest in developing superconductor electronics has been renewed due to a search for energy saving solutions in applications related to high-performance computing. The current state of superconductor electronics and fabrication processes are reviewed in order to evaluate whether this electronics is scalable to a very large scale integration (VLSI) required to achieve computation complexities comparable to CMOS processors. A fully planarized process at MIT Lincoln Laboratory, perhaps the most advanced process developed so far for superconductor electronics, is used as an example. The process has nine superconducting layers: eight Nb wiring layers with the minimum feature size of 350 nm, and a thin superconducting layer for making compact high-kinetic-inductance bias inductors. All circuit layers are fully planarized using chemical mechanical planarization (CMP) of SiO2 interlayer dielectric. The physical limitations imposed on the circuit density by Josephson junctions, circuit inductors, shunt and bias resistors, etc., are discussed. Energy dissipation in superconducting circuits is also reviewed in order to estimate whether this technology, which requires cryogenic refrigeration, can be energy efficient. Fabrication process development required for increasing the density of superconductor digital circuits by a factor of ten and achieving densities above 107 Josephson junctions per cm2 is described.

  18. Review Article: Ethical Issues in the Study of Second Language Acquisition--Resources for Researchers

    ERIC Educational Resources Information Center

    Thomas, Margaret

    2009-01-01

    Two recent books provide varied resources for exploring ethical issues in the social sciences. Reflection on ethical issues aims to sensitize scholars to a range of consequences of their research, and to scholars' responsibilities to their discipline, their colleagues, and the public. This review article assesses the utility of these texts (and of…

  19. An integrative review of global nursing workforce issues.

    PubMed

    Nichols, Barbara L; Davis, Catherine R; Richardson, Donna R

    2010-01-01

    Migration has been a way of life since the beginning of time, with migrants seeking other lands for personal and professional betterment. Today, in an era of globalization, trade agreements and technological advances, an increase in migration is inevitable. All professions have been affected, but the migration of health professionals, particularly nurses, has been the most dramatic. However, the migration of nurses across national and international borders comes with many challenges: systematic tracking of migration flows, harmonization of standards, recognition of professional credentials, fair and equitable distribution of the global health care workforce, and the effect of migration on the health care infrastructure of both source and destination countries. The international migration of nurses to address shortages in developed countries has, in some instances, left source countries with insufficient resources to address their own health care needs. The increasing complexity of health care delivery, aging of the population and the nursing workforce, and the escalating global demand for nurses create on-going challenges for policy makers. Strategically addressing global nursing workforce issues is paramount to sustaining the health of nations. PMID:21639025

  20. Invited review: gender issues related to spaceflight: a NASA perspective.

    PubMed

    Harm, D L; Jennings, R T; Meck, J V; Powell, M R; Putcha, L; Sams, C P; Schneider, S M; Shackelford, L C; Smith, S M; Whitson, P A

    2001-11-01

    This minireview provides an overview of known and potential gender differences in physiological responses to spaceflight. The paper covers cardiovascular and exercise physiology, barophysiology and decompression sickness, renal stone risk, immunology, neurovestibular and sensorimotor function, nutrition, pharmacotherapeutics, and reproduction. Potential health and functional impacts associated with the various physiological changes during spaceflight are discussed, and areas needing additional research are highlighted. Historically, studies of physiological responses to microgravity have not been aimed at examining gender-specific differences in the astronaut population. Insufficient data exist in most of the discipline areas at this time to draw valid conclusions about gender-specific differences in astronauts, in part due to the small ratio of women to men. The only astronaut health issue for which a large enough data set exists to allow valid conclusions to be drawn about gender differences is orthostatic intolerance following shuttle missions, in which women have a significantly higher incidence of presyncope during stand tests than do men. The most common observation across disciplines is that individual differences in physiological responses within genders are usually as large as, or larger than, differences between genders. Individual characteristics usually outweigh gender differences per se. PMID:11641383

  1. Invited review: gender issues related to spaceflight: a NASA perspective

    NASA Technical Reports Server (NTRS)

    Harm, D. L.; Jennings, R. T.; Meck, J. V.; Powell, M. R.; Putcha, L.; Sams, C. P.; Schneider, S. M.; Shackelford, L. C.; Smith, S. M.; Whitson, P. A.

    2001-01-01

    This minireview provides an overview of known and potential gender differences in physiological responses to spaceflight. The paper covers cardiovascular and exercise physiology, barophysiology and decompression sickness, renal stone risk, immunology, neurovestibular and sensorimotor function, nutrition, pharmacotherapeutics, and reproduction. Potential health and functional impacts associated with the various physiological changes during spaceflight are discussed, and areas needing additional research are highlighted. Historically, studies of physiological responses to microgravity have not been aimed at examining gender-specific differences in the astronaut population. Insufficient data exist in most of the discipline areas at this time to draw valid conclusions about gender-specific differences in astronauts, in part due to the small ratio of women to men. The only astronaut health issue for which a large enough data set exists to allow valid conclusions to be drawn about gender differences is orthostatic intolerance following shuttle missions, in which women have a significantly higher incidence of presyncope during stand tests than do men. The most common observation across disciplines is that individual differences in physiological responses within genders are usually as large as, or larger than, differences between genders. Individual characteristics usually outweigh gender differences per se.

  2. A review of five tests to identify motor coordination difficulties in young adults.

    PubMed

    Hands, Beth; Licari, Melissa; Piek, Jan

    2015-01-01

    Difficulties with low motor competence in childhood and adolescence, such as that seen in Developmental Coordination Disorder (DCD), often persist into adulthood. Identification of DCD at all ages is particularly challenging and problematic because of the diversity of motor symptoms. Many tests of motor proficiency and impairment have been developed for children up to 12 years of age. Whilst identification of DCD is important during childhood, it is of equal importance to identify and monitor the impact of this impairment as an individual grows and develops. Currently there is no test specifically designed to support diagnosis and monitor change in the age range 16-30 years. In this article we review five tests that have been used to assess motor competence among young adults (Bruininks-Oseretsky Test of Motor Proficiency-2, McCarron Assessment of Neuromuscular Development, Movement Assessment Battery for Children-2, Tufts Assessment of Motor Performance and the Zurich Neuromotor Assessment). Key issues relevant to testing motor skills in older populations, such as the inclusion of age appropriate skills, are explored. While the BOT-2 provided the most evidence for valid and reliable measurement of Criterion A of the diagnostic criteria for DCD among this age group, no test adequately evaluated Criterion B. Further evaluation of motor skill assessment among the young adult population is needed. PMID:26057836

  3. TOPICAL REVIEW: Prosthetic interfaces with the visual system: biological issues

    NASA Astrophysics Data System (ADS)

    Cohen, Ethan D.

    2007-06-01

    The design of effective visual prostheses for the blind represents a challenge for biomedical engineers and neuroscientists. Significant progress has been made in the miniaturization and processing power of prosthesis electronics; however development lags in the design and construction of effective machine brain interfaces with visual system neurons. This review summarizes what has been learned about stimulating neurons in the human and primate retina, lateral geniculate nucleus and visual cortex. Each level of the visual system presents unique challenges for neural interface design. Blind patients with the retinal degenerative disease retinitis pigmentosa (RP) are a common population in clinical trials of visual prostheses. The visual performance abilities of normals and RP patients are compared. To generate pattern vision in blind patients, the visual prosthetic interface must effectively stimulate the retinotopically organized neurons in the central visual field to elicit patterned visual percepts. The development of more biologically compatible methods of stimulating visual system neurons is critical to the development of finer spatial percepts. Prosthesis electrode arrays need to adapt to different optimal stimulus locations, stimulus patterns, and patient disease states.

  4. Gynecological and reproductive issues for women in space: a review.

    PubMed

    Jennings, R T; Baker, E S

    2000-02-01

    Women have been an integral part of United States space crews since the initial flight of Dr. Sally Ride in 1983, and a total of 40 women have been selected as U.S. astronauts. This article examines the reproductive and gynecological aspects of selecting, training, medically certifying, and flying women in space. Gynecological data from the astronaut selection cycles in 1991 to 1997 are reviewed. In addition, the reproductive implications of delaying childbearing for a career as an astronaut and the impact of new technology such as assisted reproductive techniques are examined. The reproductive outcomes of U.S. female astronauts after spaceflight are also presented. Because women have gained considerable operational experience on the Shuttle and Mir, the unique operational considerations for preflight certification, menstruation control and hygiene, contraception, and urination are discussed. Medical and surgical implications for women on long-duration missions to remote locations are still evolving, and enabling technologies for health care delivery are being developed. There has been considerable progress in the development of zero-gravity surgical techniques, including laparoscopy, thoracoscopy, and laparotomy. The concepts of prevention of illness, conversion of surgical conditions to medically treatable conditions, and surgical intervention for long-duration spaceflights are explored in detail. There currently are no operational gynecological or reproductive constraints for women that would preclude their successful participation in the exploration of our nearby solar system. PMID:10674254

  5. PNL technical review of pressurized thermal-shock issues. [PWR

    SciTech Connect

    Pedersen, L.T.; Apley, W.J.; Bian, S.H.; Defferding, L.J.; Morgenstern, M.H.; Pelto, P.J.; Simonen, E.P.; Simonen, F.A.; Stevens, D.L.; Taylor, T.T.

    1982-07-01

    Pacific Northwest Laboratory (PNL) was asked to develop and recommend a regulatory position that the Nuclear Regulatory Commission (NRC) should adopt regarding the ability of reactor pressure vessels to withstand the effects of pressurized thermal shock (PTS). Licensees of eight pressurized water reactors provided NRC with estimates of remaining effective full power years before corrective actions would be required to prevent an unsafe operating condition. PNL reviewed these responses and the results of supporting research and concluded that none of the eight reactors would undergo vessel failure from a PTS event before several more years of operation. Operator actions, however, were often required to terminate a PTS event before it deteriorated to the point where failure could occur. Therefore, the near-term (less than one year) recommendation is to upgrade, on a site-specific basis, operational procedures, training, and control room instrumentation. Also, uniform criteria should be developed by NRC for use during future licensee analyses. Finally, it was recommended that NRC upgrade nondestructive inspection techniques used during vessel examinations and become more involved in the evaluation of annealing requirements.

  6. A Content and Methodological Review of Articles Concerning Multiracial Issues in Six Major Counseling Journals

    ERIC Educational Resources Information Center

    Edwards, Lisa M.; Pedrotti, Jennifer Teramoto

    2008-01-01

    This study describes a comprehensive content and methodological review of articles about multiracial issues in 6 journals related to counseling up to the year 2006. The authors summarize findings about the 18 articles that emerged from this review of the "Journal of Counseling Psychology," "Journal of Counseling & Development," "The Counseling…

  7. 42 CFR 8.23 - Limitation on issues subject to review.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Limitation on issues subject to review. 8.23 Section 8.23 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures for Review of Suspension or...

  8. 42 CFR 8.23 - Limitation on issues subject to review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Limitation on issues subject to review. 8.23 Section 8.23 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures for Review of Suspension or...

  9. 42 CFR 8.23 - Limitation on issues subject to review.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Limitation on issues subject to review. 8.23 Section 8.23 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures for Review of Suspension or...

  10. Current IT Issues, 2004

    ERIC Educational Resources Information Center

    Spicer, Donald Z.; Deblois, Peter B.

    2004-01-01

    This article features the EDUCAUSE Current Issues Survey. Administered by the EDUCAUSE Current Issues Committee, whose members review and recommend the set of issues to be presented each year, the survey identifies the issues that leaders in higher education information technology see as their most critical IT challenges. The Top-Ten current IT…

  11. Ethical issues of clinical trials in paediatric oncology from 2003 to 2013: a systematic review.

    PubMed

    Dupont, Jean-Claude K; Pritchard-Jones, Kathy; Doz, François

    2016-05-01

    A state-of-the art approach to the debates on ethical issues is key in order to gain guidance on research practices involving sick children and adolescents, as well as to identify research avenues in which it might be worth cooperating, to generate better or supplementary evidence. Based on a systematic literature search using MEDLINE, we report the main ethical developments in paediatric oncology clinical trials from 2003-13. The present knowledge about normative and empirical ethical demands in this setting is quantified and summarised in a list of 46 issues. This list primarily aims to provide readers with a comprehensive account of the main decision nodes and professional attitudes that enable families to make a safe, competent, and satisfactory decision about their child's enrolment, or non-participation, in cancer clinical trials. Our systematic Review shows how important it is for professionals to engage in a constant reflection on optimum trial designs, on the effect of offering trial participation on key family dynamics, and on the ways to understand families' needs and values accurately. In view of present scientific developments, we further emphasise the need to enhance societal awareness about research in children and adolescents, to prevent so-called research fatigue in small populations due to multiple solicitations or inadequate legal demands, and to reassess longstanding ethical certainties in the strictest view of promoting sick children's interests. This systematic Review allows a series of questions to be drawn to guide and encourage collective and individual endeavours that should lead to constant improvements in our research practices in paediatric clinical oncology research. PMID:27301046

  12. 42 CFR 137.301 - How are project and program environmental review costs identified?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Construction Nepa Process § 137.301 How are project and program environmental review costs identified? (a) The... identified during the performance of the construction project, the Self-Governance Tribe or, at the request... 42 Public Health 1 2010-10-01 2010-10-01 false How are project and program environmental...

  13. Mining Health-Related Issues in Consumer Product Reviews by Using Scalable Text Analytics

    PubMed Central

    Torii, Manabu; Tilak, Sameer S.; Doan, Son; Zisook, Daniel S.; Fan, Jung-wei

    2016-01-01

    In an era when most of our life activities are digitized and recorded, opportunities abound to gain insights about population health. Online product reviews present a unique data source that is currently underexplored. Health-related information, although scarce, can be systematically mined in online product reviews. Leveraging natural language processing and machine learning tools, we were able to mine 1.3 million grocery product reviews for health-related information. The objectives of the study were as follows: (1) conduct quantitative and qualitative analysis on the types of health issues found in consumer product reviews; (2) develop a machine learning classifier to detect reviews that contain health-related issues; and (3) gain insights about the task characteristics and challenges for text analytics to guide future research. PMID:27375358

  14. Mining Health-Related Issues in Consumer Product Reviews by Using Scalable Text Analytics.

    PubMed

    Torii, Manabu; Tilak, Sameer S; Doan, Son; Zisook, Daniel S; Fan, Jung-Wei

    2016-01-01

    In an era when most of our life activities are digitized and recorded, opportunities abound to gain insights about population health. Online product reviews present a unique data source that is currently underexplored. Health-related information, although scarce, can be systematically mined in online product reviews. Leveraging natural language processing and machine learning tools, we were able to mine 1.3 million grocery product reviews for health-related information. The objectives of the study were as follows: (1) conduct quantitative and qualitative analysis on the types of health issues found in consumer product reviews; (2) develop a machine learning classifier to detect reviews that contain health-related issues; and (3) gain insights about the task characteristics and challenges for text analytics to guide future research. PMID:27375358

  15. Techniques for identifying cross-disciplinary and 'hard-to-detect' evidence for systematic review.

    PubMed

    O'Mara-Eves, Alison; Brunton, Ginny; McDaid, David; Kavanagh, Josephine; Oliver, Sandy; Thomas, James

    2014-03-01

    Driven by necessity in our own complex review, we developed alternative systematic ways of identifying relevant evidence where the key concepts are generally not focal to the primary studies' aims and are found across multiple disciplines-that is, hard-to-detect evidence. Specifically, we sought to identify evidence on community engagement in public health interventions that aim to reduce health inequalities. Our initial search strategy used text mining to identify synonyms for the concept 'community engagement'. We conducted a systematic search for reviews on public health interventions, supplemented by searches of trials databases. We then used information in the reviews' evidence tables to gather more information about the included studies than was evident in the primary studies' own titles or abstracts. We identified 319 primary studies cited in reviews after full-text screening. In this paper, we retrospectively reflect on the challenges and benefits of the approach taken. We estimate that more than a quarter of the studies that were identified would have been missed by typical searching and screening methods. This identification strategy was highly effective and could be useful for reviews of broad research questions, or where the key concepts are unlikely to be the main focus of primary research. PMID:26054025

  16. Identifying national health research priorities in Timor-Leste through a scoping review of existing health data

    PubMed Central

    2013-01-01

    Health research is crucial to understand a country’s needs and to improve health outcomes. We conducted a scoping review and analysis of existing health data in Timor-Leste to identify the health research priorities of the country. Published and unpublished health research in Timor-Leste from 2001 to 2011 that reported objectives, methods and results were identified. Key findings were triangulated with data from national surveys and the Health Management Information System; 114 eligible articles were included in the analysis, the leading topics of which were communicable (malaria, tuberculosis, HIV and sexually transmitted diseases and dengue) and non-communicable (eye and mental health) diseases. There were 28 papers (25%) on safe motherhood, child health and nutrition, of which 20 (71%) were unpublished. The review of national indicators showed high infant, under-five and maternal mortality rates. Burden of disease is greatest in young children, with respiratory infections, febrile illnesses and diarrheal disease predominating. There is poor access to and utilization of health care. Childhood malnutrition is an important unresolved national health issue. There are several obstacles leading to under-utilization of health services. The following topics for future health research are suggested from the review: nutrition, safe motherhood, childhood illness (in particular identifying the causes and cause-specific burden of severe respiratory, febrile and diarrheal diseases) and access to and use of health services. PMID:23452321

  17. Identifying the Trends and Impact of Graduate Attributes on Employability: A Literature Review

    ERIC Educational Resources Information Center

    Osmani, Mohamad; Weerakkody, Vishanth; Hindi, Nitham M.; Al-Esmail, Rajab; Eldabi, Tillal; Kapoor, Kawaljeet; Irani, Zahir

    2015-01-01

    Graduate employability has become an issue since there are broad mismatches between the acquired graduate skills from university and the required skills by employers. While previous researches have outlined the salient skills that need to be embedded in graduate education, to date no studies have attempted to methodically identify and synthesize…

  18. Journal Reviewer Ratings: Issues of Particularistic Bias, Agreement, and Predictive Validity within the Manuscript Review Process

    ERIC Educational Resources Information Center

    Vecchio, Robert P.

    2006-01-01

    Reviewer evaluations and recommendations for 853 manuscript submissions, over a span of 4 years, are analyzed for evidence of particularistic bias, reviewer agreement, and predictive validity for forecasting a published manuscript's citation impact. Attributes of the submitters, their affiliated institutions, and the reviewers have little…

  19. Trichloroethylene and Cancer: Systematic and Quantitative Review of Epidemiologic Evidence for Identifying Hazards

    PubMed Central

    Scott, Cheryl Siegel; Jinot, Jennifer

    2011-01-01

    We conducted a meta-analysis focusing on studies with high potential for trichloroethylene (TCE) exposure to provide quantitative evaluations of the evidence for associations between TCE exposure and kidney, liver, and non-Hodgkin lymphoma (NHL) cancers. A systematic review documenting essential design features, exposure assessment approaches, statistical analyses, and potential sources of confounding and bias identified twenty-four cohort and case-control studies on TCE and the three cancers of interest with high potential for exposure, including five recently published case-control studies of kidney cancer or NHL. Fixed- and random-effects models were fitted to the data on overall exposure and on the highest exposure group. Sensitivity analyses examined the influence of individual studies and of alternative risk estimate selections. For overall TCE exposure and kidney cancer, the summary relative risk (RRm) estimate from the random effects model was 1.27 (95% CI: 1.13, 1.43), with a higher RRm for the highest exposure groups (1.58, 95% CI: 1.28, 1.96). The RRm estimates were not overly sensitive to alternative risk estimate selections or to removal of an individual study. There was no apparent heterogeneity or publication bias. For NHL, RRm estimates for overall exposure and for the highest exposure group, respectively, were 1.23 (95% CI: 1.07, 1.42) and 1.43 (95% CI: 1.13, 1.82) and, for liver cancer, 1.29 (95% CI: 1.07, 1.56) and 1.28 (95% CI: 0.93, 1.77). Our findings provide strong support for a causal association between TCE exposure and kidney cancer. The support is strong but less robust for NHL, where issues of study heterogeneity, potential publication bias, and weaker exposure-response results contribute uncertainty, and more limited for liver cancer, where only cohort studies with small numbers of cases were available. PMID:22163205

  20. A review of utility issues for the integration of wind electric generators

    NASA Technical Reports Server (NTRS)

    Reddoch, T. W.; Barnes, P. R.

    1982-01-01

    A review of issues and concerns of the electric utility industry for the integration of wind electric generation is offered. The issues have been categorized in three major areas: planning, operations, and dynamic interaction. Representative studies have been chosen for each area to illustrate problems and to alleviate some concerns. The emphasis of this paper is on individual large wind turbines (WTs) and WT arrays for deployment at the bulk level in a utility system.

  1. Integrative Literature Review: Methods in Identifying Exemplary Performance--A Review of the Literature and Implications for HRD

    ERIC Educational Resources Information Center

    Smith, Terri Freeman

    2008-01-01

    This literature review provides an analysis of relevant ASTD (American Society for Training & Development) competency studies in Workplace Learning and Performance (WLP) and other research findings related to the methodology used in identifying exemplary and average performers. These findings helped create the research model and methods used in…

  2. Mental Health Issues of Women After Release From Jail and Prison: A Systematic Review.

    PubMed

    Stanton, Ann E; Kako, Peninnah; Sawin, Kathleen J

    2016-05-01

    The aim of this review article is to gain an understanding of the mental health issues of women released from jail or prison. Thirty-six studies were synthesized using the biopsychosocial model. Results indicate that released women's mental health issues include psychiatric diagnoses, psychological trauma, substance use disorders; access to psychological medications and services; and motherhood challenges, support, access to basic needs, and criminalized behaviors. Nurses can promote released women's mental health through pre-release assessment and treatment of mental health issues and ensuring access to post-release resources.  Future research should examine released women's mental health experiences. PMID:27100407

  3. Pharmaceuticalisation and ethical review in South Asia: issues of scope and authority for practitioners and policy makers.

    PubMed

    Simpson, Bob; Khatri, Rekha; Ravindran, Deapica; Udalagama, Tharindi

    2015-04-01

    Ethical review by expert committee continues to be the first line of defence when it comes to protecting human subjects recruited into clinical trials. Drawing on a large scale study of biomedical experimentation across South Asia, and specifically on interviews with 24 ethical review committee [ERC] members across India, Sri Lanka and Nepal, this article identifies some of the tensions that emerge for ERC members as the capacity to conduct credible ethical review of clinical trials is developed across the region. The article draws attention to fundamental issues of scope and authority in the operation of ethical review. On the one hand, ERC members experience a powerful pull towards harmonisation and a strong alignment with international standards deemed necessary for the global pharmaceutical assemblage to consolidate and extend. On the other hand, they must deal with what is in effect the double jeopardy of ethical review in developing world contexts. ERC members must undertake review but are frequently made aware of their responsibility to protect interests that go beyond the 'human subject' and into the realms of development and national interest [for example, in relation to literacy and informed consent]. These dilemmas are indicative of broader questions about where ethical review sits in institutional terms and how it might develop to best ensure improved human subject protection given growth of industry-led research. PMID:24768272

  4. Top 10 IT Issues, 2007

    ERIC Educational Resources Information Center

    Camp, John S.; DeBlois, Peter B.

    2007-01-01

    The EDUCAUSE Current Issues Committee, whose members review and recommend the set of IT issues to be presented each year, conducted a Web-based survey in December 2006 to identify the five of thirty-one IT issues in each of four areas: (1) issues that are critical for strategic success; (2) issues that are expected to increase in significance; (3)…

  5. It Top-10 Issues 2006

    ERIC Educational Resources Information Center

    Dewey, Barbara I.; DeBlois, Peter B.

    2006-01-01

    The EDUCAUSE Current Issues Committee, whose members review and recommend the set of IT issues to be presented each year, conducted a Web-based survey in December 2005 to identify the five of thirty-one IT issues in each of four areas: (1) issues that are critical for strategic success; (2) issues that are expected to increase in significance; (3)…

  6. Review of Technical Issues Related to Predicting Isotopic Compositions and Source Terms for High-Burnup LWR Fuel

    SciTech Connect

    Gauld, I. C.; Parks, C. V.

    2000-12-11

    This report has been prepared to review the technical issues important to the prediction of isotopic compositions and source terms for high-burnup, light-water-reactor (LWR) fuel as utilized in the licensing of spent fuel transport and storage systems. The current trend towards higher initial 235U enrichments, more complex assembly designs, and more efficient fuel management schemes has resulted in higher spent fuel burnups than seen in the past. This trend has led to a situation where high-burnup assemblies from operating LWRs now extend beyond the area where available experimental data can be used to validate the computational methods employed to calculate spent fuel inventories and source terms. This report provides a brief review of currently available validation data, including isotopic assays, decay heat measurements, and shielded dose-rate measurements. Potential new sources of experimental data available in the near term are identified. A review of the background issues important to isotopic predictions and some of the perceived technical challenges that high-burnup fuel presents to the current computational methods are discussed. Based on the review, the phenomena that need to be investigated further and the technical issues that require resolution are presented. The methods and data development that may be required to address the possible shortcomings of physics and depletion methods in the high-burnup and high-enrichment regime are also discussed. Finally, a sensitivity analysis methodology is presented. This methodology is currently being investigated at the Oak Ridge National Laboratory as a computational tool to better understand the changing relative significance of the underlying nuclear data in the different enrichment and burnup regimes and to identify the processes that are dominant in the high-burnup regime. The potential application of the sensitivity analysis methodology to help establish a range of applicability for experimental

  7. Integrative Review of Social Presence in Distance Education: Issues and Challenges

    ERIC Educational Resources Information Center

    Chen, Xin; Fang, Youjia; Lockee, Barbara

    2015-01-01

    The purpose of this review is to provide an overview of the evolution of social presence research in the field of distance education and identified problems in investigating this construct. The researchers took an integrative review on existing social presence studies to answer three questions: (a) How definitions of social presence evolved since…

  8. Identifying Barriers in Implementing Outcomes-Based Assessment Program Review: A Grounded Theory Analysis

    ERIC Educational Resources Information Center

    Bresciani, Marilee J.

    2011-01-01

    The purpose of this grounded theory study was to identify the typical barriers encountered by faculty and administrators when implementing outcomes-based assessment program review. An analysis of interviews with faculty and administrators at nine institutions revealed a theory that faculty and administrators' promotion, tenure (if applicable),…

  9. Evaluating the Validity of Systematic Reviews to Identify Empirically Supported Treatments

    ERIC Educational Resources Information Center

    Slocum, Timothy A.; Detrich, Ronnie; Spencer, Trina D.

    2012-01-01

    The "best available evidence" is one of the three basic inputs into evidence-based practice. This paper sets out a framework for evaluating the quality of systematic reviews that are intended to identify empirically supported interventions as a way of summarizing the best available evidence. The premise of this paper is that the process of…

  10. Collaborative Consultation to Support Children with Pediatric Health Issues: A Review of the Biopsychoeducational Model

    ERIC Educational Resources Information Center

    Grier, Betsy Chesno; Bradley-Klug, Kathy L.

    2011-01-01

    Medical technology continues to improve, increasing life expectancies and capabilities of children with chronic illnesses and disabilities. Pediatric health issues have an impact on children's academic, emotional, behavioral, and social functioning. This article reviews a consultative Biopsychoeducational Model, based on a problem-solving process,…

  11. 77 FR 68790 - Program Comment Issued for Streamlining Section 106 Review for Actions Affecting Post-1945...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-16

    .../archive/NotesDocs/25-25%2815%29_FR.pdf ). (A) Reinforced concrete slab bridges (i) Reinforced concrete... Concrete and Steel Bridges AGENCY: Advisory Council on Historic Preservation. ACTION: Program Comment issued for streamlining Section 106 review for undertakings affecting post-1945 concrete and...

  12. Long-Distance Relationships in Dual-Career Commuter Couples: A Review of Counseling Issues.

    ERIC Educational Resources Information Center

    Rhodes, Angel R.

    2002-01-01

    The dual-career commuter couple is an alternative family configuration that continues to grow in number. Reviews the literature on dual-career commuter couples that has been published since 1982. Addresses the counseling issues of marital and family characteristics, commuting characteristics, and decision-making styles. Counseling implications and…

  13. 22 CFR 216.9 - Bilateral and multilateral studies and concise reviews of environmental issues.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Bilateral and multilateral studies and concise reviews of environmental issues. 216.9 Section 216.9 Foreign Relations AGENCY FOR INTERNATIONAL... United States and one or more foreign countries or by an international body or organization in which...

  14. Pre-Service Teacher Cohorts: Characteristics and Issues--A Review of the Literature

    ERIC Educational Resources Information Center

    Knorr, Ron

    2012-01-01

    Since their introduction to teacher education programs in the 1980s, teacher education cohorts have become a standard scheme of organization in teacher preparation programs. This literature review notes some common characteristics and issues in cohort operations. Cohorts contain a standard academic core, class scheduling, and timeline to program…

  15. Legal Issues inherent in space shuttle operations. [reviewed by NASA Deputy General Counsel

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The legal issues inherent in NASA's proceeding into the day-to-day operations of the space shuttle and other elements of the Space Transportation System are considered in light of the National Aeronautics and Space Act of 1958. Based on this review, it was concluded that there is no immediate need for substantive amendments to that legislation.

  16. American Indian Policy Review Commission Special Joint Task Force Report on Alaskan Native Issues.

    ERIC Educational Resources Information Center

    Congress of the U.S. Washington, DC. American Indian Policy Review Commission.

    Impact of the Alaskan Native Claims Settlement Act (ANCSA) on Alaskan Natives, particularly at village levels, is the focus of a joint task force report on Alaskan Native issues. Prepared for the American Indian Policy Review Commission, the report is the work of representatives from task forces on tribal government, federal, state, and tribal…

  17. 22 CFR 216.9 - Bilateral and multilateral studies and concise reviews of environmental issues.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Bilateral and multilateral studies and concise reviews of environmental issues. 216.9 Section 216.9 Foreign Relations AGENCY FOR INTERNATIONAL... United States and one or more foreign countries or by an international body or organization in which...

  18. Systematic Reviews Published in the October 2015 Issue of the Cochrane Library.

    PubMed

    Wiffen, Philip J

    2016-01-01

    The Cochrane Library of Systematic Reviews is published quarterly as a DVD and monthly online (http://www.thecochranelibrary.com). The October 2015 issue (fourth DVD for 2015) contains 6622 complete reviews, 2429 protocols for reviews in production, and 36,600 short summaries of systematic reviews published in the general medical literature (this short summary database is no longer being updated). In addition, there are citations of 848,000 randomized controlled trials, and 15,700 cited papers in the Cochrane Methodology Register. The Health Technology Assessment database contains some 15,000 citations. One hundred and nine new reviews have been published in the previous 3 months, of which six have potential relevance for practitioners in pain and palliative medicine. The impact factor of the Cochrane Library stands at 5.939. Readers are encouraged to access the full report for any articles of interest as only a brief commentary is provided. PMID:27007584

  19. A systematic review of ethical issues in vaccine studies involving pregnant women

    PubMed Central

    Beeler, Jennifer A.; Lambach, Philipp; Fulton, T. Roice; Narayanan, Divya; Ortiz, Justin R.; Omer, Saad B.

    2016-01-01

    ABSTRACT Background: Immunization during pregnancy can provide protection for mother and child. However, there have been only a limited number of studies documenting the efficacy and safety of this strategy. Aims: To determine the extent and nature of subject matter related to ethics in maternal immunization by systematically documenting the spectrum of ethical issues in vaccine studies involving pregnant women. Method: We conducted a systematic literature review of published works pertaining to vaccine and therapeutic studies involving pregnant women through searches of PubMed, EMBASE, Web of Science, the Cochrane Database, and ClinicalTrials.gov. We selected literature meeting the inclusion criteria published between 1988 and June 2014. We systematically abstracted subject matter pertaining to ethical issues in immunization studies during pregnancy. Immunization-specific ethical issues were matched and grouped into major categories and subcategories. Results: Seventy-seven published articles met the inclusion criteria. Published articles reported findings on data that had been collected in 26 countries, the majority of which were classified as high-income or upper-middle-income nations according to World Bank criteria. Review of these publications produced 60 immunization-specific ethical issues, grouped into six major categories. Notably, many studies demonstrated limited acknowledgment of key ethical issues including the rights and welfare of participants. Additionally, there was no discussion pertaining to the ethics of program implementation, including integration of maternal immunization programs into existing routine immunization programs. Conclusion: This review of ethical issues in immunization studies of pregnant women can be used to help inform future vaccine trials in this important population. Consistent documentation of these ethical issues by investigators will facilitate a broader and more nuanced discussion of ethics in immunization of pregnant

  20. Preliminary Review of Safety Assessment Issues at Savannah River Site, August 2011

    SciTech Connect

    Napier, Bruce A.; Rishel, Jeremy P.; Bixler, Nathan E.

    2011-09-19

    At the request of Savannah River Nuclear Solutions (SRNS) management, a review team composed of experts in atmospheric transport modeling for environmental radiation dose assessment convened at the Savannah River Site (SRS) on August 29-30, 2011. Several issues were presented at the meeting for discussion. This is a short summary that is organized in accordance with the primary issues discussed, which is not necessarily a chronological record. Issues include: SRS Meteorological Data and its Use in MACCS2; Deposition Velocities for Particles; Deposition Velocities for Tritium; MACCS2 Dispersion Coefficients; Use of Low Surface Roughness in Open Areas; Adequacy of Meteorological Tower and Instrumentation; Displacement Height; and Validity of MACCS2 Calculations at Close-in Distances. A longer report will be issued at a later date that expands upon these topics and recommendations.

  1. 76 FR 58846 - Final Interim Staff Guidance: Review of Evaluation To Address Gas Accumulation Issues in Safety...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... guidance documents. Disposition: On November 12, 2009 (74 FR 58323), the NRC staff issued proposed DC/COL....5.2, ``Containment Spray System'' of NUREG-0800, ``Standard Review Plan for the Review of...

  2. Identifying management competencies for health care executives: review of a series of Delphi studies.

    PubMed

    Hudak, R P; Brooke, P P; Finstuen, K

    2000-01-01

    This analysis reviews a selected body of research that identifies the essential areas of management expertise required of future health care executives. To ensure consistency, six studies are analyzed, utilizing the Delphi technique, to query a broad spectrum of experts in different fields and sites of health care management. The analysis identifies a number of management competencies, i.e., managerial capabilities, which current and aspiring health care executives, in various settings and with differing educational backgrounds, should possess to enhance the probability of their success in current and future positions of responsibility. In addition, this review identifies the skills (technical expertise), knowledge (facts and principles) and abilities (physical, mental or legal power) required to support achievement of these competencies. Leadership and resource management, including cost and finance dimensions, are the highest-rated requisite management competencies. The dominant skills, knowledge and abilities (SKAs) are related to interpersonal skills. The lowest-rated SKAs are related to job-specific, technical skills. Recommendations include the review of this research by formal and continuing education programs to determine the content of their courses and areas for future research. Similarly, current health care executives should assess this research to assist in identifying competency gaps. Lastly, this analysis recommends that the Delphi technique, as a valid and replicable methodology, be applied toward the study of non-executive health care managers, e.g., students, clinicians, mid-level managers and integrated systems administrators, to determine their requisite management competencies and SKAs. PMID:11183260

  3. Performance of a mixed filter to identify relevant studies for mixed studies reviews

    PubMed Central

    El Sherif, Reem; Pluye, Pierre; Gore, Genevieve; Granikov, Vera; Hong, Quan Nha

    2016-01-01

    Objective Mixed studies reviews include empirical studies with diverse designs. Given that identifying relevant studies for such reviews is time consuming, a mixed filter was developed. Methods The filter was used for six journals from three disciplines. For each journal, database records were coded “empirical” (relevant) when they mentioned a research question or objective, data collection, analysis, and results. We measured precision (proportion of retrieved documents being relevant), sensitivity (proportion of relevant documents retrieved), and specificity (proportion of nonrelevant documents not retrieved). Results Records were coded with and without the filter, and descriptive statistics were performed, suggesting the mixed filter has high sensitivity. PMID:26807052

  4. Risk-rated health insurance programs: a review of designs and important issues.

    PubMed

    Kaelin, M A; Barr, J K; Golaszewski, T; Warshaw, L J

    1992-01-01

    PURPOSE OF THE REVIEW. The purpose of this review is to assist those who work in the field of health promotion when considering the implementation of an individually risk-rated health insurance plan. It does so by introducing the reader to the concept of individually risk-rating health insurance; uncritically reviewing selected risk-rated health insurance plans; and exploring several issues related to plan implementation, administration, and appropriateness. SEARCH METHODS USED. The review is based on the authors' awareness of the literature in the fields of preventive medicine, health promotion, and employee benefits. The six individually risk-rated health insurance programs that are reviewed were chosen because they demonstrate how aspects of the National Association of Insurance Commissioners' Model have been implemented using various combinations of administrative procedures, verification strategies, and types of economic incentives or disincentives. This review is not intended to be a comprehensive review of the literature. SUMMARY OF IMPORTANT FINDINGS. Individually risk-rated health insurance programs have been established using a variety of administrative procedures, verification strategies, and types of economic incentives or disincentives. The frequency with which these programs are being established is increasing. As the number of risk-rated programs grows, it will be increasingly important to address the many issues that implementing such plans generate: How should lifestyle behaviors be verified? Will healthy lifestyles save money? Can employees fully control their risk factors? Is risk-rating socially responsible? MAJOR CONCLUSIONS. As risk-rating becomes more widespread, there will be a continuing need to address the business, medical, ethical, and legal issues these programs create and to refine them accordingly. The health promotion community has both an opportunity and obligation to see to it that individually risk-rated health insurance programs

  5. Ethical Issues Surrounding End-of-Life Care: A Narrative Review

    PubMed Central

    Karnik, Sameera; Kanekar, Amar

    2016-01-01

    End-of-life care decision making carries paramount importance due to the advancements in medical sciences. Since medical science has evolved over the time and now has a potentiality to reshape the circumstances during death and in turn prolong lives, various ethical issues surround end-of-life care. The purpose of this narrative review is to discuss issues such as autonomous decision making, importance of advance directives, rationing of care in futile treatments and costs involved in providing end-of-life care. Even though much progress has been made in this area continued advancement in medical science demands further research into this topic. PMID:27417612

  6. Ethical Issues Surrounding End-of-Life Care: A Narrative Review.

    PubMed

    Karnik, Sameera; Kanekar, Amar

    2016-01-01

    End-of-life care decision making carries paramount importance due to the advancements in medical sciences. Since medical science has evolved over the time and now has a potentiality to reshape the circumstances during death and in turn prolong lives, various ethical issues surround end-of-life care. The purpose of this narrative review is to discuss issues such as autonomous decision making, importance of advance directives, rationing of care in futile treatments and costs involved in providing end-of-life care. Even though much progress has been made in this area continued advancement in medical science demands further research into this topic. PMID:27417612

  7. eTBLAST: a web server to identify expert reviewers, appropriate journals and similar publications.

    PubMed

    Errami, Mounir; Wren, Jonathan D; Hicks, Justin M; Garner, Harold R

    2007-07-01

    Authors, editors and reviewers alike use the biomedical literature to identify appropriate journals in which to publish, potential reviewers for papers or grants, and collaborators (or competitors) with similar interests. Traditionally, this process has either relied upon personal expertise and knowledge or upon a somewhat unsystematic and laborious process of manually searching through the literature for trends. To help with these tasks, we report three utilities that parse and summarize the results of an abstract similarity search to find appropriate journals for publication, authors with expertise in a given field, and documents similar to a submitted query. The utilities are based upon a program, eTBLAST, designed to identify similar documents within literature databases such as (but not limited to) MEDLINE. These services are freely accessible through the Internet at http://invention.swmed.edu/etblast/etblast.shtml, where users can upload a file or paste text such as an abstract into the browser interface. PMID:17452348

  8. Intimate Partner Violence in Self-Identified Lesbians: A Systematic Review of Its Prevalence and Correlates.

    PubMed

    Badenes-Ribera, Laura; Bonilla-Campos, Amparo; Frias-Navarro, Dolores; Pons-Salvador, Gemma; Monterde-I-Bort, Hector

    2016-07-01

    This article presents the first systematic review on intimate partner violence (IPV) in self-identified lesbians in same-sex couples. Studies published from January 1990 to December 2013 were analyzed. Of the 687 studies reviewed, 59 were preselected, of which 14 studies were selected that met the inclusion and methodological quality criteria. A summary is presented of the characteristics of the studies, the participants, the prevalence of IPV victimization and perpetration, and its correlates. All the studies were carried out in the United States and used a nonprobabilistic sampling method. The majority of participants were White with a high educational level. The results indicate that all the forms of violence occur, but the most prevalent is emotional/psychological violence. The correlates positively associated with IPV are certain personality characteristics, fusion, previous IPV experience, a family history of violence, and alcohol consumption. This review finds significant limitations in the analyzed literature. Methodological recommendations are made for future studies. PMID:26018210

  9. Identifying low-value clinical practices in critical care medicine: protocol for a scoping review

    PubMed Central

    Niven, Daniel J; McCormick, T Jared; Straus, Sharon E; Hemmelgarn, Brenda R; Jeffs, Lianne P; Stelfox, Henry T

    2015-01-01

    Introduction Reducing unnecessary, low-value clinical practice (ie, de-adoption) is key to improving value for money in healthcare, especially among patients admitted to intensive care units (ICUs) where resource consumption exceeds other medical and surgical populations. Research suggests that low-value clinical practices are common in medicine, however systematically and objectively identifying them is a widely cited barrier to de-adoption. We will conduct a scoping review to identify low-value clinical practices in adult critical care medicine that are candidates for de-adoption. Methods and analysis We will systematically search the literature to identify all randomised controlled trials or systematic reviews that focus on diagnostic or therapeutic interventions in adult patients admitted to medical, surgical or specialty ICUs, and are published in 3 general medical journals with the highest impact factor (New England Journal of Medicine, The Lancet, Journal of the American Medical Association). 2 investigators will independently screen abstracts and full-text articles against inclusion criteria, and extract data from included citations. Included citations will be classified according to whether or not they represent a repeat examination of the given research question (ie, replication research), and whether the results are similar or contradictory to the original study. Studies with contradictory results will determine clinical practices that are candidates for de-adoption. Ethics and dissemination Our scoping review will use robust methodology to systematically identify a list of clinical practices in adult critical care medicine with evidence supporting their de-adoption. In addition to adding to advancing the study of de-adoption, this review may also serve as the launching point for clinicians and researchers in critical care to begin reducing the number of low-value clinical practices. Dissemination of these results to relevant stakeholders will include

  10. Psycho-Socio-Economic Issues Challenging Multidrug Resistant Tuberculosis Patients: A Systematic Review

    PubMed Central

    Thomas, Beena Elizabeth; Shanmugam, Poonguzhali; Malaisamy, Muniyandi; Ovung, Senthanro; Suresh, Chandra; Subbaraman, Ramnath; Adinarayanan, Srividya; Nagarajan, Karikalan

    2016-01-01

    Background Limited treatment options, long duration of treatment and associated toxicity adversely impact the physical and mental well-being of multidrug-resistant tuberculosis (MDR-TB) patients. Despite research advances in the microbiological and clinical aspects of MDR-TB, research on the psychosocial context of MDR-TB is limited and less understood. Methodology We searched the databases of PubMed, MEDLINE, Embase and Google Scholar to retrieve all published articles. The final manuscripts included in the review were those with a primary focus on psychosocial issues of MDR-TB patients. These were assessed and the information was thematically extracted on the study objective, methodology used, key findings, and their implications. Intervention studies were evaluated using components of the methodological and quality rating scale. Due to the limited number of studies and the multiple methodologies employed in the observational studies, we summarized these studies using a narrative approach, rather than conducting a formal meta-analysis. We used ‘thematic synthesis’ method for extracting qualitative evidences and systematically organised to broader descriptive themes. Results A total of 282 published articles were retrieved, of which 15 articles were chosen for full text review based on the inclusion criteria. Six were qualitative studies; one was a mixed methods study; and eight were quantitative studies. The included studies were divided into the following issues affecting MDR-TB patients: a) psychological issues b) social issues and economic issues c) psychosocial interventions. It was found that all studies have documented range of psychosocial and economic challenges experienced by MDR-TB patients. Depression, stigma, discrimination, side effects of the drugs causing psychological distress, and the financial constraints due to MDR-TB were some of the common issues reported in the studies. There were few intervention studies which addressed these

  11. Treatment of biodiversity issues in impact assessment of electricity power transmission lines: A Finnish case review

    SciTech Connect

    Soederman, Tarja . E-mail: tarja.soderman@ymparisto.fi

    2006-05-15

    The Environmental Impact Assessment (EIA) process concerning the route of a 400 kV power transmission line between Loviisa and Hikiae in southern Finland was reviewed in order to assess how biodiversity issues are treated and to provide suggestions on how to improve the effectiveness of treatment of biodiversity issues in impact assessment of linear development projects. The review covered the whole assessment process, including interviews of stakeholders, participation in the interest group meetings and review of all documents from the project. The baseline studies and assessment of direct impacts in the case study were detailed but the documentation, both the assessment programme and the assessment report, only gave a partial picture of the assessment process. All existing information, baseline survey and assessment methods should be addressed in the scoping phase in order to promote interaction between all stakeholders. In contrast to the assessment of the direct effects, which first emphasized impacts on the nationally important and protected flying squirrel but later expanded to deal with the assessment of impacts on ecologically important sites, the indirect and cumulative impacts of the power line were poorly addressed. The public was given the opportunity to become involved in the EIA process. However, they were more concerned with impacts on their properties and less so on biodiversity and species protection issues. This suggests that the public needs to become more informed about locally important features of biodiversity.

  12. Drug-related problems (DRPs) identified from geriatric medication safety review clinics.

    PubMed

    Chan, Ding-Cheng; Chen, Jen-Hau; Kuo, Hsu-Ko; We, Chiung-Jung; Lu, I-Shu; Chiu, Lee-Shu; Wu, Shwu-Chong

    2012-01-01

    Drug-related problems (DRPs) were identified from baseline data of 193 Medication Safety Review Clinic (MSRC) patients. MSRCs enroll older adults (≥ 65 years) with either (1) prescriptions of ≥ 8 chronic medications (drugs prescribed for ≥ 28 days) or (2) a visit to ≥ 3 different physicians at the two participating hospitals in Taipei, Taiwan from August to October 2007. The Pharmaceutical Care Network Europe (PCNE) Classification Version 5.01 was used to report DRPs. Mean age was 76.2 ± 6.2 years and 53% of participants were male. Participants had, on average, 9.0 ± 2.6 chronic conditions and took 8.9 ± 3.1 chronic medications and 1.7 ± 1.8 dietary supplements. Eighty-seven percent had at least one DRP. Being older, having orthostatic hypotension and taking more chronic medications were associated with higher likelihood of having at least one DRP. For the 1713 medications and 331 diet supplements reviewed, 427 DRPs were found, 490 causes (1.1 ± 0.4 per problem) identified and 1067 interventions proposed (2.5 ± 0.6 per problem). The most common DRP category was "drug not taken/administered" (35%), and the most common offending drug category was cardiovascular agents (33%). Prevalence of DRPs was high among geriatric outpatients prescribed multiple medications. Careful medication review is needed in routine clinical practice to improve prescription quality. PMID:21353318

  13. Workgroup report: review of fish bioaccumulation databases used to identify persistent, bioaccumulative, toxic substances.

    PubMed

    Weisbrod, Anne V; Burkhard, Lawrence P; Arnot, Jon; Mekenyan, Ovanes; Howard, Philip H; Russom, Christine; Boethling, Robert; Sakuratani, Yuki; Traas, Theo; Bridges, Todd; Lutz, Charles; Bonnell, Mark; Woodburn, Kent; Parkerton, Thomas

    2007-02-01

    Chemical management programs strive to protect human health and the environment by accurately identifying persistent, bioaccumulative, toxic substances and restricting their use in commerce. The advance of these programs is challenged by the reality that few empirical data are available for the tens of thousands of commercial substances that require evaluation. Therefore, most preliminary assessments rely on model predictions and data extrapolation. In November 2005, a workshop was held for experts from governments, industry, and academia to examine the availability and quality of in vivo fish bioconcentration and bioaccumulation data, and to propose steps to improve its prediction. The workshop focused on fish data because regulatory assessments predominantly focus on the bioconcentration of substances from water into fish, as measured using in vivo tests or predicted using computer models. In this article we review of the quantity, features, and public availability of bioconcentration, bioaccumulation, and biota-sediment accumulation data. The workshop revealed that there is significant overlap in the data contained within the various fish bioaccumulation data sources reviewed, and further, that no database contained all of the available fish bioaccumulation data. We believe that a majority of the available bioaccumulation data have been used in the development and testing of quantitative structure-activity relationships and computer models currently in use. Workshop recommendations included the publication of guidance on bioconcentration study quality, the combination of data from various sources to permit better access for modelers and assessors, and the review of chemical domains of existing models to identify areas for expansion. PMID:17384774

  14. Workplace-based assessment: a review of user perceptions and strategies to address the identified shortcomings.

    PubMed

    Massie, Jonathan; Ali, Jason M

    2016-05-01

    Workplace based assessments (WBAs) are now commonplace in postgraduate medical training. User acceptability and engagement is essential to the success of any medical education innovation. To this end, possessing an insight into trainee and trainer perceptions towards WBAs will help identify the major problems, permitting strategies to be introduced to improve WBA implementation. A review of literature was performed to identify studies examining trainee and trainer perceptions towards WBAs. Studies were excluded if non-English or sampling a non-medical/dental population. The identified literature was synthesised for the purpose of this critical narrative review. It is clear that there is widespread negativity towards WBAs in the workplace. This has negatively impacted on the effectiveness of WBA tools as learning aids. This negativity exists in trainees but also to an extent in their trainers. Insight gained from the literature reveals three dominant problems with WBA implementation: poor understanding as to the purpose of WBAs; insufficient time available for undertaking these assessments; and inadequate training of trainers. Approaches to addressing these three problems with WBA implementation are discussed. It is likely that a variety of solutions will be required. The prevalence of negativity towards WBAs is substantial in both trainees and trainers, eroding the effectiveness of learning that is consequent upon them. The educational community must now listen to the concerns being raised by the users and consider the range of strategies being proposed to improve the experiences of trainees, and their trainers. PMID:26003590

  15. The challenge of identifying non-intentionally added substances from food packaging materials: a review.

    PubMed

    Nerin, C; Alfaro, P; Aznar, M; Domeño, C

    2013-05-01

    Packaged food can contain non-intentionally added substances (NIAS) as a result of reaction and degradation processes or the presence of impurities in the raw materials used for the packaging production. This manuscript reviews the evidence of NIAS and their possible origin. One of the most challenging and difficult tasks when a sample of packaging materials arrives at the laboratory is knowing the procedure to apply for identifying the unknown compounds. This work proposes an analytical procedure for sample treatment, applicable to polymers as well as to migration samples, and for NIAS identification. The identification protocol comprises the determination of both volatile and non-volatile compounds. A review is presented of the most novel analytical techniques used for identification purposes, particularly high resolution mass spectrometry (HRMS). PMID:23601971

  16. Implementing a Continuum of Evidence-Based Psychosocial Interventions for People With Severe Mental Illness: Part 2—Review of Critical Implementation Issues

    PubMed Central

    Briand, Catherine; Menear, Matthew

    2014-01-01

    Objective: In North America and internationally, efforts have been made to reduce the gaps between knowledge of psychosocial evidence-based practices (EBPs) and the delivery of such services in routine mental health practice. Part 2 of this review identifies key issues for stakeholders to consider when implementing comprehensive psychosocial EBPs for people with severe mental illness (SMI). Method: A rapid review of the literature was conducted. Searches were carried out in MEDLINE and PsycINFO for reports published between 1990 and 2012 using key words related to SMI, and psychosocial practices and implementation. The Consolidated Framework for Implementation Research (CFIR) was used to structure findings according to key domains and constructs known to influence the implementation process. Results: The CFIR allowed us to identify 17 issues reflecting more than 30 constructs of the framework that were viewed as influential to the process of implementing evidence-based psychosocial interventions for people with SMI. Issues arising at different levels of influence (intervention, individual, organizational, and system) and at all phases of the implementation process (planning, engagement, execution, and evaluation) were found to play important roles in implementation. Conclusion: The issues identified in this review should be taken into consideration by stakeholders when engaging in efforts to promote uptake of new psychosocial EBPs and to widen the range of effective psychosocial services available in routine mental health care. PMID:25007111

  17. Identifying and tracking disaster victims: state-of-the-art technology review.

    PubMed

    Pate, Barbara L

    2008-01-01

    The failure of our nation to adequately track victims of Hurricane Katrina has been identified as a major weakness of national and local disaster preparedness plans. This weakness has prompted government and private industries to acknowledge that existing paper-based tracking systems are incapable of managing information during a large-scale disaster. In response to this need, efforts are under way to develop new technologies that allow instant access to identity and location information during emergency situations. The purpose of this article is to provide a review of state-of-the-art technologies, with implications and limitations for use during mass casualty incidents. PMID:18091082

  18. Advanced manufacturing technology effectiveness: A review of literature and some issues

    NASA Astrophysics Data System (ADS)

    Goyal, Sanjeev; Grover, Sandeep

    2012-09-01

    Advanced manufacturing technology (AMT) provides advantages to manufacturing managers in terms of flexibility, quality, reduced delivery times, and global competitiveness. Although a large number of publications had presented the importance of this technology, only a few had delved into related literature review. Considering the importance of this technology and the recent contributions by various authors, the present paper conducts a more comprehensive review. Literature was reviewed in a way that will help researchers, academicians, and practitioners to take a closer look at the implementation, evaluation, and justification of the AMT. The authors reviewed various papers, proposed a different classification scheme, and identified certain gaps that will provide hints for further research in AMT management.

  19. ICD-10 codes used to identify adverse drug events in administrative data: a systematic review

    PubMed Central

    Hohl, Corinne M; Karpov, Andrei; Reddekopp, Lisa; Stausberg, Jürgen

    2014-01-01

    Background Adverse drug events, the unintended and harmful effects of medications, are important outcome measures in health services research. Yet no universally accepted set of International Classification of Diseases (ICD) revision 10 codes or coding algorithms exists to ensure their consistent identification in administrative data. Our objective was to synthesize a comprehensive set of ICD-10 codes used to identify adverse drug events. Methods We developed a systematic search strategy and applied it to five electronic reference databases. We searched relevant medical journals, conference proceedings, electronic grey literature and bibliographies of relevant studies, and contacted content experts for unpublished studies. One author reviewed the titles and abstracts for inclusion and exclusion criteria. Two authors reviewed eligible full-text articles and abstracted data in duplicate. Data were synthesized in a qualitative manner. Results Of 4241 titles identified, 41 were included. We found a total of 827 ICD-10 codes that have been used in the medical literature to identify adverse drug events. The median number of codes used to search for adverse drug events was 190 (IQR 156–289) with a large degree of variability between studies in the numbers and types of codes used. Authors commonly used external injury (Y40.0–59.9) and disease manifestation codes. Only two papers reported on the sensitivity of their code set. Conclusions Substantial variability exists in the methods used to identify adverse drug events in administrative data. Our work may serve as a point of reference for future research and consensus building in this area. PMID:24222671

  20. Identifying Potential Types of Guidance for Supporting Student Inquiry When Using Virtual and Remote Labs in Science: A Literature Review

    ERIC Educational Resources Information Center

    Zacharia, Zacharias C.; Manoli, Constantinos; Xenofontos, Nikoletta; de Jong, Ton; Pedaste, Margus; van Riesen, Siswa A.; Kamp, Ellen T.; Mäeots, Mario; Siiman, Leo; Tsourlidaki, Eleftheria

    2015-01-01

    The aim of this review is to identify specific types of guidance for supporting student use of online labs, that is, virtual and remote labs, in an inquiry context. To do so, we reviewed the literature on providing guidance within computer supported inquiry learning (CoSIL) environments in science education and classified all identified guidance…

  1. Researching experiences of terminal cancer: a systematic review of methodological issues and approaches.

    PubMed

    Harris, F M; Kendall, M; Bentley, A; Maguire, R; Worth, A; Murray, S; Boyd, K; Brown, D; Kearney, N; Sheikh, A

    2008-07-01

    The objectives of this review were to assess the methods and approaches applied to end-of-life cancer research based on papers focusing on approaches or methodological issues related to seeking the views of people affected by terminal cancer. A comprehensive search of 10 databases (January 1980-February 2004) was undertaken. References were screened, quality assessed and data extracted by two reviewers. Analysis followed a meta-narrative approach. Fifteen papers were included. They discussed 'traditional' approaches, such as focus groups, interviews, surveys, as well as innovative approaches allied to the arts. They reveal that mixed methods are gaining popularity. The emotional demands placed on researchers and the ethical issues involved in this research area were also discussed. We concluded that researchers should embrace innovative approaches from other areas of social science, such as the use of arts-based techniques. This may facilitate recruitment of the hard-to-reach groups and engage with experiences that may be otherwise difficult to verbalize. Although researching the needs of the dying carries challenges, these are not the exclusive domain of the cancer field. This study reveals that diverse methods, from research-based drama to postal questionnaires, can enhance end-of-life research. However, this review reveals the need for more methodological work to be undertaken and disseminated. PMID:18485015

  2. Scale Issues in Remote Sensing: A Review on Analysis, Processing and Modeling

    PubMed Central

    Wu, Hua; Li, Zhao-Liang

    2009-01-01

    With the development of quantitative remote sensing, scale issues have attracted more and more the attention of scientists. Research is now suffering from a severe scale discrepancy between data sources and the models used. Consequently, both data interpretation and model application become difficult due to these scale issues. Therefore, effectively scaling remotely sensed information at different scales has already become one of the most important research focuses of remote sensing. The aim of this paper is to demonstrate scale issues from the points of view of analysis, processing and modeling and to provide technical assistance when facing scale issues in remote sensing. The definition of scale and relevant terminologies are given in the first part of this paper. Then, the main causes of scale effects and the scaling effects on measurements, retrieval models and products are reviewed and discussed. Ways to describe the scale threshold and scale domain are briefly discussed. Finally, the general scaling methods, in particular up-scaling methods, are compared and summarized in detail. PMID:22573986

  3. A review of potable water accessibility and sustainability issues in developing countries - case study of Uganda.

    PubMed

    Nayebare, Shedrack R; Wilson, Lloyd R; Carpenter, David O; Dziewulski, David M; Kannan, Kurunthachalam

    2014-01-01

    Providing sources of sustainable and quality potable water in Uganda is a significant public health issue. This project aimed at identifying and prioritizing possible actions on how sustainable high quality potable water in Uganda's water supply systems could be achieved. In that respect, a review of both the current water supply systems and government programs on drinking water in Uganda was completed. Aspects of quantity, quality, treatment methods, infrastructure, storage and distribution of water for different water systems were evaluated and compared with the existing water supply systems in the U.S., Latin America and the Caribbean, for purposes of generating feasible recommendations and opportunities for improvement. Uganda utilizes surface water, groundwater, and rainwater sources for consumption. Surface water covers 15.4% of the land area and serves both urban and rural populations. Lake Victoria contributes about 85% of the total fresh surface water. Potable water quality is negatively affected by the following factors: disposal of sewage and industrial effluents, agricultural pesticides and fertilizers, and surface run-offs during heavy rains. The total renewable groundwater resources in Uganda are estimated to be 29 million m3/year with about 20,000 boreholes, 3000 shallow-wells and 200,000 springs, serving more than 80% of the rural and slum communities. Mean annual rainfall in Uganda ranges from 500 mm to 2500 mm. Groundwater and rainwater quality is mainly affected by poor sanitation and unhygienic practices. There are significant regional variations in the accessibility of potable water, with the Northeastern region having the least amount of potable water from all sources. Uganda still lags behind in potable water resource development. Priorities should be placed mainly on measures available for improvement of groundwater and rainwater resource utilization, protection of watersheds, health education, improved water treatment methods and

  4. Key issues in automatic classification of defects in post-inspection review process of photomasks

    NASA Astrophysics Data System (ADS)

    Pereira, Mark; Maji, Manabendra; Pai, Ravi R.; B. V. R., Samir; Seshadri, R.; Patil, Pradeepkumar

    2012-11-01

    The mask inspection and defect classification is a crucial part of mask preparation technology and consumes a significant amount of mask preparation time. As the patterns on a mask become smaller and more complex, the need for a highly precise mask inspection system with high detection sensitivity becomes greater. However, due to the high sensitivity, in addition to the detection of smaller defects on finer geometries, the inspection machine could report large number of false defects. The total number of defects becomes significantly high and the manual classification of these defects, where the operator should review each of the defects and classify them, may take huge amount of time. Apart from false defects, many of the very small real defects may not print on the wafer and user needs to spend time on classifying them as well. Also, sometimes, manual classification done by different operators may not be consistent. So, need for an automatic, consistent and fast classification tool becomes more acute in more advanced nodes. Automatic Defect Classification tool (NxADC) which is in advanced stage of development as part of NxDAT1, can automatically classify defects accurately and consistently in very less amount of time, compared to a human operator. Amongst the prospective defects as detected by the Mask Inspection System, NxADC identifies several types of false defects such as false defects due to registration error, false defects due to problems with CCD, noise, etc. It is also able to automatically classify real defects such as, pin-dot, pin-hole, clear extension, multiple-edges opaque, missing chrome, chrome-over-MoSi, etc. We faced a large set of algorithmic challenges during the course of the development of our NxADC tool. These include selecting the appropriate image alignment algorithm to detect registration errors (especially when there are sub-pixel registration errors or misalignment in repetitive patterns such as line space), differentiating noise from

  5. A review of approaches to identifying patient phenotype cohorts using electronic health records

    PubMed Central

    Shivade, Chaitanya; Raghavan, Preethi; Fosler-Lussier, Eric; Embi, Peter J; Elhadad, Noemie; Johnson, Stephen B; Lai, Albert M

    2014-01-01

    Objective To summarize literature describing approaches aimed at automatically identifying patients with a common phenotype. Materials and methods We performed a review of studies describing systems or reporting techniques developed for identifying cohorts of patients with specific phenotypes. Every full text article published in (1) Journal of American Medical Informatics Association, (2) Journal of Biomedical Informatics, (3) Proceedings of the Annual American Medical Informatics Association Symposium, and (4) Proceedings of Clinical Research Informatics Conference within the past 3 years was assessed for inclusion in the review. Only articles using automated techniques were included. Results Ninety-seven articles met our inclusion criteria. Forty-six used natural language processing (NLP)-based techniques, 24 described rule-based systems, 41 used statistical analyses, data mining, or machine learning techniques, while 22 described hybrid systems. Nine articles described the architecture of large-scale systems developed for determining cohort eligibility of patients. Discussion We observe that there is a rise in the number of studies associated with cohort identification using electronic medical records. Statistical analyses or machine learning, followed by NLP techniques, are gaining popularity over the years in comparison with rule-based systems. Conclusions There are a variety of approaches for classifying patients into a particular phenotype. Different techniques and data sources are used, and good performance is reported on datasets at respective institutions. However, no system makes comprehensive use of electronic medical records addressing all of their known weaknesses. PMID:24201027

  6. Persons with intellectual disabilities in the criminal justice system: review of issues.

    PubMed

    Jones, Jessica

    2007-12-01

    Although the vast majority of individuals with intellectual disabilities (ID) are law-abiding citizens, there is a small percentage with offending behaviour that is considered antisocial, socially inappropriate, or defined as illegal. It has long been recognised that individuals with ID or mental-health needs who break the law should be dealt with differently from the general population. There have been an increasing number of empirical studies in this area; however, these have been plagued by various definitional and methodological issues. Prevalence estimates of offenders with ID are complicated by diagnostic variations and inconsistencies in the criminal justice process. International studies have shown a large range, from 2% to 40%, depending on methodological approaches. The following review will highlight the salient issues including prevalence of offending, characteristics of offenders, vulnerabilities within the legal system, assessment, and a brief overview of intervention and treatment approaches. PMID:17636203

  7. Non-invasive prenatal testing for fetal chromosome abnormalities: review of clinical and ethical issues

    PubMed Central

    Gekas, Jean; Langlois, Sylvie; Ravitsky, Vardit; Audibert, François; van den Berg, David Gradus; Haidar, Hazar; Rousseau, François

    2016-01-01

    Genomics-based non-invasive prenatal screening using cell-free DNA (cfDNA screening) was proposed to reduce the number of invasive procedures in current prenatal diagnosis for fetal aneuploidies. We review here the clinical and ethical issues of cfDNA screening. To date, it is not clear how cfDNA screening is going to impact the performances of clinical prenatal diagnosis and how it could be incorporated in real life. The direct marketing to users may have facilitated the early introduction of cfDNA screening into clinical practice despite limited evidence-based independent research data supporting this rapid shift. There is a need to address the most important ethical, legal, and social issues before its implementation in a mass setting. Its introduction might worsen current tendencies to neglect the reproductive autonomy of pregnant women. PMID:26893576

  8. One-Dimensional Oxide Nanostructures as Gas-Sensing Materials: Review and Issues

    PubMed Central

    Choi, Kyoung Jin; Jang, Ho Won

    2010-01-01

    In this article, we review gas sensor application of one-dimensional (1D) metal-oxide nanostructures with major emphases on the types of device structure and issues for realizing practical sensors. One of the most important steps in fabricating 1D-nanostructure devices is manipulation and making electrical contacts of the nanostructures. Gas sensors based on individual 1D nanostructure, which were usually fabricated using electron-beam lithography, have been a platform technology for fundamental research. Recently, gas sensors with practical applicability were proposed, which were fabricated with an array of 1D nanostructures using scalable micro-fabrication tools. In the second part of the paper, some critical issues are pointed out including long-term stability, gas selectivity, and room-temperature operation of 1D-nanostructure-based metal-oxide gas sensors. PMID:22319343

  9. Fitness for duty in the nuclear power industry: A review of technical issues

    SciTech Connect

    Moore, C.; Barnes, V.; Hauth, J.; Wilson, R.; Fawcett-Long, J.; Toquam, J.; Baker, K.; Wieringa, D.; Olson, J.; Christensen, J.

    1989-05-01

    This report presents information gathered and analyzed in support of the US Nuclear Regulatory Commission's (NRC's) efforts to develop a rule that will ensure that workers with unescorted access to protected areas of nuclear power plants are fit for duty. This report supplements information previously published in NUREG/CR-5227, Fitness for Duty in the Nuclear Power Industry: A Review of Technical Issues (Barnes et al., 1988). The primary potential fitness-for-duty concern addressed in both of these reports is impairment caused by substance abuse, although other fitness concerns are discussed. This report addresses issues pertaining to workers' use and misuse of alcohol, prescription drugs, and over-the-counter drugs as fitness-for-duty concerns; responds to several questions raised by NRC Commissioners; discusses subversion of the chemical testing process and methods of preventing such subversion; and examines concerns about the urinalysis cutoff levels used when testing for marijuana metabolites, amphetamines, and phencyclidine (PCP).

  10. Non-invasive prenatal testing for fetal chromosome abnormalities: review of clinical and ethical issues.

    PubMed

    Gekas, Jean; Langlois, Sylvie; Ravitsky, Vardit; Audibert, François; van den Berg, David Gradus; Haidar, Hazar; Rousseau, François

    2016-01-01

    Genomics-based non-invasive prenatal screening using cell-free DNA (cfDNA screening) was proposed to reduce the number of invasive procedures in current prenatal diagnosis for fetal aneuploidies. We review here the clinical and ethical issues of cfDNA screening. To date, it is not clear how cfDNA screening is going to impact the performances of clinical prenatal diagnosis and how it could be incorporated in real life. The direct marketing to users may have facilitated the early introduction of cfDNA screening into clinical practice despite limited evidence-based independent research data supporting this rapid shift. There is a need to address the most important ethical, legal, and social issues before its implementation in a mass setting. Its introduction might worsen current tendencies to neglect the reproductive autonomy of pregnant women. PMID:26893576

  11. To twist or poke? A method for identifying usability issues with the rotary controller and touch screen for control of in-vehicle information systems.

    PubMed

    Harvey, Catherine; Stanton, Neville A; Pickering, Carl A; McDonald, Mike; Zheng, Pengjun

    2011-07-01

    In-vehicle information systems (IVIS) can be controlled by the user via direct or indirect input devices. In order to develop the next generation of usable IVIS, designers need to be able to evaluate and understand the usability issues associated with these two input types. The aim of this study was to investigate the effectiveness of a set of empirical usability evaluation methods for identifying important usability issues and distinguishing between the IVIS input devices. A number of usability issues were identified and their causal factors have been explored. These were related to the input type, the structure of the menu/tasks and hardware issues. In particular, the translation between inputs and on-screen actions and a lack of visual feedback for menu navigation resulted in lower levels of usability for the indirect device. This information will be useful in informing the design of new IVIS, with improved usability. STATEMENT OF RELEVANCE: This paper examines the use of empirical methods for distinguishing between direct and indirect IVIS input devices and identifying usability issues. Results have shown that the characteristics of indirect input devices produce more serious usability issues, compared with direct devices and can have a negative effect on the driver-vehicle interaction. PMID:21770749

  12. Identifying the decision to be supported: a review of papers from environmental modelling and software

    USGS Publications Warehouse

    Sojda, Richard S.; Chen, Serena H.; El Sawah, Sondoss; Guillaume, Joseph H.A.; Jakeman, A.J.; Lautenbach, Sven; McIntosh, Brian S.; Rizzoli, A.E.; Seppelt, Ralf; Struss, Peter; Voinov, Alexey; Volk, Martin

    2012-01-01

    Two of the basic tenets of decision support system efforts are to help identify and structure the decisions to be supported, and to then provide analysis in how those decisions might be best made. One example from wetland management would be that wildlife biologists must decide when to draw down water levels to optimise aquatic invertebrates as food for breeding ducks. Once such a decision is identified, a system or tool to help them make that decision in the face of current and projected climate conditions could be developed. We examined a random sample of 100 papers published from 2001-2011 in Environmental Modelling and Software that used the phrase “decision support system” or “decision support tool”, and which are characteristic of different sectors. In our review, 41% of the systems and tools related to the water resources sector, 34% were related to agriculture, and 22% to the conservation of fish, wildlife, and protected area management. Only 60% of the papers were deemed to be reporting on DSS. This was based on the papers reviewed not having directly identified a specific decision to be supported. We also report on the techniques that were used to identify the decisions, such as formal survey, focus group, expert opinion, or sole judgment of the author(s). The primary underlying modelling system, e.g., expert system, agent based model, Bayesian belief network, geographical information system (GIS), and the like was categorised next. Finally, since decision support typically should target some aspect of unstructured decisions, we subjectively determined to what degree this was the case. In only 23% of the papers reviewed, did the system appear to tackle unstructured decisions. This knowledge should be useful in helping workers in the field develop more effective systems and tools, especially by being exposed to the approaches in different, but related, disciplines. We propose that a standard blueprint for reporting on DSS be developed for

  13. A review of nuclear thermal propulsion carbide fuel corrosion and key issues

    NASA Technical Reports Server (NTRS)

    Pelaccio, Dennis G.; El-Genk, Mohamed S.

    1994-01-01

    Corrosion (mass loss) of carbide nuclear fuels due to their exposure to hot hydrogen in nuclear thermal propulsion engine systems greatly impacts the performance, thrust-to-weight and life of such systems. This report provides an overview of key issues and processes associated with the corrosion of carbide materials. Additionally, past pertinent development reactor test observations, as well as related experimental work and analysis modeling efforts are reviewed. At the conclusion, recommendations are presented, which provide the foundation for future corrosion modeling and verification efforts.

  14. Final Review of Safety Assessment Issues at Savannah River Site, August 2011

    SciTech Connect

    Napier, Bruce A.; Rishel, Jeremy P.; Bixler, Nathan E.

    2011-12-15

    At the request of Savannah River Nuclear Solutions (SRNS) management, a review team composed of experts in atmospheric transport modeling for environmental radiation dose assessment convened at the Savannah River Site (SRS) on August 29-30, 2011. Though the meeting was prompted initially by suspected issues related to the treatment of surface roughness inherent in the SRS meteorological dataset and its treatment in the MELCOR Accident Consequence Code System Version 2 (MACCS2), various topical areas were discussed that are relevant to performing safety assessments at SRS; this final report addresses these topical areas.

  15. Mental health issues among migrant workers in Gulf Cooperation Council countries: literature review and case illustrations.

    PubMed

    Kronfol, Ziad; Saleh, Marwa; Al-Ghafry, Maha

    2014-08-01

    More than 15 million non-nationals are currently living and working in Gulf Cooperation Council (GCC) states. The majority are blue-collar or domestic workers coming from the Indian Subcontinent or South East Asia. They often work under very harsh conditions. There are reports of a high rate of psychosis and suicide among these people but no reliable data are available. To address this issue we conducted a literature search both in English and in Arabic to review the available articles on the psychological well-being of this population. Very few articles were found. We hereby review the available literature and contribute by presenting several brief vignettes to illustrate the various clinical aspects of this at risk population. We also discuss possible reasons for underreporting and underscore the need for more research in this area. PMID:25042963

  16. PETC review: A global role for energy. Issue 10, Summer 1994

    SciTech Connect

    Rhee, K.H.; Friedman, S.; Eastman, M.L.; Finseth, D.H.; Ruth, L.A.; Reiss, J.

    1994-10-01

    This issue contains five feature articles. `Build It and They Will Come` describes the international reputation of the Pittsburgh Energy Technology Center which prompts professionals from around the world to come to PETC for training, technical expertise, and collaboration on research projects. `PETC`s Overseas Activities` reviews international projects with which PETC staff have helped. The most prestigious of all conferences dedicated solely to the timely international exchange of basic scientific information on coal is described in `The 7th International Conference on Coal Science`. `What is Coal?` attempts to present a true picture of the nature and complexity of coal. `NOx Reduction by SCR/SNCR` reviews technologies which may be required to meet new NOx compliance standards.

  17. A review of equity issues in quantitative studies on health inequalities: the case of asthma in adults

    PubMed Central

    2011-01-01

    Background The term 'inequities' refers to avoidable differences rooted in injustice. This review examined whether or not, and how, quantitative studies identifying inequalities in risk factors and health service utilization for asthma explicitly addressed underlying inequities. Asthma was chosen because recent decades have seen strong increases in asthma prevalence in many international settings, and inequalities in risk factors and related outcomes. Methods A review was conducted of studies that identified social inequalities in asthma-related outcomes or health service use in adult populations. Data were extracted on use of equity terms (objective evidence), and discussion of equity issues without using the exact terms (subjective evidence). Results Of the 219 unique articles retrieved, 21 were eligible for inclusion. None used the terms equity/inequity. While all but one article traced at least partial pathways to inequity, only 52% proposed any intervention and 55% of these interventions focused exclusively on the more proximal, clinical level. Conclusions Without more in-depth and systematic examination of inequities underlying asthma prevalence, quantitative studies may fail to provide the evidence required to inform equity-oriented interventions to address underlying circumstances restricting opportunities for health. PMID:21749720

  18. A review of return to play issues and sports-related concussion.

    PubMed

    Doolan, Amy W; Day, Daniel D; Maerlender, Arthur C; Goforth, Michael; Gunnar Brolinson, P

    2012-01-01

    Mild traumatic brain injury in sports has become a significant public health concern which has not only received the general public's attention through multiple news media stories involving athletic concussions, but has also resulted in local, state, and national legislative efforts to improve recognition and management. The purpose of this article is to review the current literature for return to play (RTP) guidelines. State, regional, national, and professional legislation on sport-related concussion RTP management issues will be reviewed. This article will be helpful in developing a generalized systematic approach to concussion management and highlight specific RTP guidelines. The article will also touch upon specific contraindications to RTP, the role of neuropsychological testing in RTP, and other considerations and complications that affect an athlete's ability to return to competition. Finally, considerations for terminating an athlete's competitive season or ending a career after sustaining a concussion resulting in prolonged and protracted symptomatology or repeated concussions will be reviewed. PubMed and Google were searched using the key terms mentioned below. In addition, the author's library of concussion-related articles was reviewed for the relevant literature. PMID:21997390

  19. Current status of coastal zone issues and management in China: a review.

    PubMed

    Cao, Wenzhi; Wong, Ming H

    2007-10-01

    This paper identifies and examines social-economic and environmental issues recently emerged in China's coastal zone. Evaluation of management scheme and progress in perspectives of coordinated legislation, institutional arrangement, public participation, capacity building, and scientific research (mainly coastal planning and functional zoning) in China's coastal zone are made. The Chinese government has made a significant effort in developing legislation for the coastal zone. Jurisdictional and zoning boundaries, and allocating use rights for coastal and marine resources have been established. State Oceanic Administration is the leading agency responsible for China's ocean policymaking and overall management of ocean and coastal affairs. A demonstrated project for integrated coastal management in Xiamen has been implemented, and is characterized as "decentralization" approach in decision-making process. In view of the above, comprehensive coastal management in China is a big challenge, facing with many difficulties. Finally, recommendations are raised for tackling these issues for China's coastal zone management. PMID:17532045

  20. The quantitative genetics of indirect genetic effects: a selective review of modelling issues.

    PubMed

    Bijma, P

    2014-01-01

    Indirect genetic effects (IGE) occur when the genotype of an individual affects the phenotypic trait value of another conspecific individual. IGEs can have profound effects on both the magnitude and the direction of response to selection. Models of inheritance and response to selection in traits subject to IGEs have been developed within two frameworks; a trait-based framework in which IGEs are specified as a direct consequence of individual trait values, and a variance-component framework in which phenotypic variance is decomposed into a direct and an indirect additive genetic component. This work is a selective review of the quantitative genetics of traits affected by IGEs, with a focus on modelling, estimation and interpretation issues. It includes a discussion on variance-component vs trait-based models of IGEs, a review of issues related to the estimation of IGEs from field data, including the estimation of the interaction coefficient Ψ (psi), and a discussion on the relevance of IGEs for response to selection in cases where the strength of interaction varies among pairs of individuals. An investigation of the trait-based model shows that the interaction coefficient Ψ may deviate considerably from the corresponding regression coefficient when feedback occurs. The increasing research effort devoted to IGEs suggests that they are a widespread phenomenon, probably particularly in natural populations and plants. Further work in this field should considerably broaden our understanding of the quantitative genetics of inheritance and response to selection in relation to the social organisation of populations. PMID:23512010

  1. Economic evidence on identifying clinically actionable findings with whole-genome sequencing: a scoping review.

    PubMed

    Douglas, Michael P; Ladabaum, Uri; Pletcher, Mark J; Marshall, Deborah A; Phillips, Kathryn A

    2016-02-01

    The American College of Medical Genetics and Genomics (ACMG) recommends that mutations in 56 genes for 24 conditions are clinically actionable and should be reported as secondary findings after whole-genome sequencing (WGS). Our aim was to identify published economic evaluations of detecting mutations in these genes among the general population or among targeted/high-risk populations and conditions and identify gaps in knowledge. A targeted PubMed search from 1994 through November 2014 was performed, and we included original, English-language articles reporting cost-effectiveness or a cost-to-utility ratio or net benefits/benefit-cost focused on screening (not treatment) for conditions and genes listed by the ACMG. Articles were screened, classified as targeting a high-risk or general population, and abstracted by two reviewers. General population studies were evaluated for actual cost-effectiveness measures (e.g., incremental cost-effectiveness ratios (ICER)), whereas studies of targeted populations were evaluated for whether at least one scenario proposed was cost-effective (e.g., ICER of ≤$100,000 per life-year or quality-adjusted life-year gained). A total of 607 studies were identified, and 32 relevant studies were included. Identified studies addressed fewer than one-third (7 of 24; 29%) of the ACMG conditions. The cost-effectiveness of screening in the general population was examined for only 2 of 24 conditions (8%). The cost-effectiveness of most genetic findings that the ACMG recommends for return has not been evaluated in economic studies or in the context of screening in the general population. The individual studies do not directly address the cost-effectiveness of WGS. PMID:25996638

  2. Identifying and Responding to Ethical and Methodological Issues in After-Death Interviews with Next-of-Kin

    ERIC Educational Resources Information Center

    Williams, Beverly R.; Woodby, Lesa L.; Bailey, F. Amos; Burgio, Kathryn L.

    2008-01-01

    After-death research with next-of-kin can enhance our understanding of end-of-life care and translate into better services for dying persons and their survivors. This article describes ethical and methodological issues that emerged in a pilot of a face-to-face interview guide designed to elicit next-of-kin's perceptions of end-of-life care. The…

  3. Predictors of Extubation Failure in Neurocritical Patients Identified by a Systematic Review and Meta-Analysis

    PubMed Central

    Huang, Kaibin; Lin, Zhenzhou; Qiao, Weiguang; Pan, Suyue

    2014-01-01

    Background Prediction of extubation failure, particularly in neurocritical patients, is unique and controversial. We conducted a systematic review and meta-analysis to identify the risk factors for extubation failure in these patients. Methods A literature search of databases (MEDLINE, EMBASE, the Cochrane Library, and Web of Science) was performed up to August of 2013 to identify trials that evaluated extubation failure predictors. Included trials were either prospective or retrospective cohort studies. Results Nine studies involving 928 participants were included. The systematic review and meta-analysis revealed that the following were predictive for extubation failure: pneumonia, atelectasis, mechanical ventilation of >24 h, a low Glasgow Coma Scale score (7–9T) (OR = 4.96, 95% CI = 1.61–15.26, P = 0.005), the inability to follow commands (OR = 2.07, 95% CI = 1.15–3.71, P = 0.02), especially the command to close the eyes, thick secretion, and no intact gag reflex. Meanwhile, the following were not predictive for extubation failure: sex, secretion volume, coughing upon suctioning, and the inability to follow one command among showing two fingers, wiggling the toes, or coughing on command. Additionally, some traditional weaning parameters were shown to poorly predict extubation failure in neurocritical patients. Conclusions Besides pneumonia, atelectasis, and the duration of mechanical ventilation, other factors that should be taken into consideration in the prediction of extubation failure when neurocritical patients are weaned from tracheal intubation include neurologic abilities (Glasgow Coma Scale score and following commands), the secretion texture, and the presence of a gag reflex. PMID:25486091

  4. 10 CFR 2.621 - Acceptance and docketing of application for early review of site suitability issues in a combined...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Cfr Part 52 § 2.621 Acceptance and docketing of application for early review of site suitability... of site suitability issues in a combined license proceeding. 2.621 Section 2.621 Energy NUCLEAR... Procedures Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an...

  5. Identifying and solving lead issues from water systems with materials/device replacement in drinking water system configurations

    EPA Science Inventory

    Identifying and assessing lead contamination and exposure potentialin single-family residences is difficult enough, but doing the samekind of assessment and remediation in buildings, schools, and daycare centers is even more challenging. It is of particular importancebecause of t...

  6. Breast Cancer Survivorship: A Comprehensive Review of Long-Term Medical Issues and Lifestyle Recommendations

    PubMed Central

    Bodai, Balazs I; Tuso, Phillip

    2015-01-01

    Long-term survival rates after a diagnosis of breast cancer are steadily rising. This is good news, but clinicians must also recognize that this brings new challenges to the medical community. As breast cancer becomes a chronic condition rather than a life-threatening illness owing to advances in early diagnosis and more effective treatments, health care practitioners must recognize and manage the long-term sequelae of the constellation of therapeutic modalities. Survivors of breast cancer represent a unique and extremely complex group of patients; not only do they have the challenge of dealing with multiple long-term side effects of treatment protocols, but many are also forced to address the preexisting comorbidities of their therapies, which often include multiple other issues. Therapies have additional and/or additive side effects that may interfere with treatments directed toward the new primary diagnosis of breast cancer. Our mandate is to establish a smooth transition from patient with breast cancer to survivor of breast cancer while providing ongoing and future guidance. Certainly, the information and resources to accomplish this transition are readily available; however, they are scattered throughout the literature and therefore are not easily accessible or available to the primary care physician. It is imperative that the information available regarding survivorship issues be accessible in an organized and useful format. This article is a modest attempt to provide a comprehensive review of the long-term medical issues relevant to survivorship after the diagnosis and treatment of breast cancer. A predicted shortage of oncologists by 2020 is well-recognized. Therefore, the bulk of long-term care will become dependent on the primary care physician. This shift of care means that these physicians will need to be well educated in the long-term medical issues related to breast cancer treatment. PMID:25902343

  7. Mental health issues amongst medical students in Asia: a systematic review [2000–2015

    PubMed Central

    Sayampanathan, Andrew Arjun; Ho, Roger Chun-Man

    2016-01-01

    Background Studies have shown that the stress experienced by medical students is far greater than that experienced by other university students. In this study, we aim to understand the consequent mental health issues that are experienced by medical students, particularly in Asia, via a systematic review of the current literature. Methods Initial searches on MEDLINE, Embase and SpringerLink came up with a total of 1,033 unique articles. Studies not focusing on medical students alone, not mentioning mental health issues or not containing prevalence values were excluded. Results We included 14 articles in our analysis. ADs had a prevalence of 7.04% (100/1,420). Depression was prevalent in 11.0% (1,115/10,147) of students. A total of 12.9% (54/420) and 12.9% (41/319) of male and female medical students respectively were screened for depression. Preclinical students were also 1.63 times more likely to be depressed compared to clinical students, with 98.0% (48/49) pre-clinical students having screened for depression, compared to 60% (27/45) clinical students. Home staying medical students are 1.33 times more likely to be depressed compared to hostel-stayers, with 12.1% (29/239) of home stayers being depressed compared to 9.2% (37/402) of hostel stayers. Conclusions We found that mental health issues affect a significant proportion of medical students and they are more prevalent in certain subpopulations of medical students. Our data revealed that preclinical and home staying students can be more susceptible to depression. More research should be done regarding this issue. With such information, it is hoped that appropriate interventions can be designed to improve the mental health of medical students. PMID:27004219

  8. Hyperprolactinemia and medications for bipolar disorder: systematic review of a neglected issue in clinical practice.

    PubMed

    Pacchiarotti, Isabella; Murru, Andrea; Kotzalidis, Georgios D; Bonnin, C Mar; Mazzarini, Lorenzo; Colom, Francesc; Vieta, Eduard

    2015-08-01

    Drug-induced changes in serum prolactin (sPrl) levels constitute a relevant issue due to the potentially severe consequences on physical health of psychiatric patients such as sexual dysfunctions, osteoporosis and Prl-sensitive tumors. Several drugs have been associated to sPrl changes. Only antipsychotics have been extensively studied as sPrl-elevating agents in schizophrenia, but the extent to which bipolar disorder (BD) treatments affect sPrl levels is much less known. The objective of this systematic review is to summarize the evidence of the effects of drugs used in BD on Prl. This review followed the PRISMA statement. The MEDLINE/PubMed/Index Medicus, EMBASE, and Cochrane Library databases were systematically searched for articles in English appearing from any time to May 30, 2014. Twenty-six studies were included. These suggest that treatments for BD are less likely to be associated with Prl elevations, with valproate, quetiapine, lurasidone, mirtazapine, and bupropion reported not to change PRL levels significantly and lithium and aripiprazole to lower them in some studies. Taking into account the effects of the different classes of drugs on Prl may improve the care of BD patients requiring long-term pharmacotherapy. Based on the results of this review, lithium and valproate appear to be safer due to their low potential to elevate sPrL; among antipsychotics, quetiapine, lurasidone and aripiprazole appear to be similarly safe. PMID:25937241

  9. Professional Development in International Schools; Issues of Inclusion Identified by a Group of International School Teaching Assistants

    ERIC Educational Resources Information Center

    Tarry, Estelle; Cox, Anna

    2014-01-01

    With the growth in numbers of teaching assistants (TAs) in the UK, it has been identified through research carried out on behalf of the Council of British International Schools (COBIS) research that TAs in British international schools have specific and unmet training needs. Following the development of a course for TAs in international contexts,…

  10. Identifying and Solving Lead Issues from Water Systems with Materials/Device Replacement in Schools and other Buildings

    EPA Science Inventory

    Identifying and assessing lead contamination and exposure potential in single-family residences is difficult enough, but doing the same kind of assessment and remediation in buildings, schools, and day care centers is even more challenging. It is of particular importance because ...

  11. Identifying and Solving Lead Issues from Water Systems with Materials/Device Replacement in Schools and other Buildings - slides

    EPA Science Inventory

    Identifying and assessing lead contamination and exposure potential in single-family residences is difficult enough, but doing the same kind of assessment and remediation in buildings, schools, and day care centers is even more challenging. It is of particular importance because ...

  12. Identifying and assessing the risk of opioid abuse in patients with cancer: an integrative review

    PubMed Central

    Carmichael, Ashley-Nicole; Morgan, Laura; Del Fabbro, Egidio

    2016-01-01

    Background The misuse and abuse of opioid medications in many developed nations is a health crisis, leading to increased health-system utilization, emergency department visits, and overdose deaths. There are also increasing concerns about opioid abuse and diversion in patients with cancer, even at the end of life. Aims To evaluate the current literature on opioid misuse and abuse, and more specifically the identification and assessment of opioid-abuse risk in patients with cancer. Our secondary aim is to offer the most current evidence of best clinical practice and suggest future directions for research. Materials and methods Our integrative review included a literature search using the key terms “identification and assessment of opioid abuse in cancer”, “advanced cancer and opioid abuse”, “hospice and opioid abuse”, and “palliative care and opioid abuse”. PubMed, PsycInfo, and Embase were supplemented by a manual search. Results We found 691 articles and eliminated 657, because they were predominantly non cancer populations or specifically excluded cancer patients. A total of 34 articles met our criteria, including case studies, case series, retrospective observational studies, and narrative reviews. The studies were categorized into screening questionnaires for opioid abuse or alcohol, urine drug screens to identify opioid misuse or abuse, prescription drug-monitoring programs, and the use of universal precautions. Conclusion Screening questionnaires and urine drug screens indicated at least one in five patients with cancer may be at risk of opioid-use disorder. Several studies demonstrated associations between high-risk patients and clinical outcomes, such as aberrant behavior, prolonged opioid use, higher morphine-equivalent daily dose, greater health care utilization, and symptom burden. PMID:27330340

  13. Municipal solid waste incineration in China and the issue of acidification: A review.

    PubMed

    Ji, Longjie; Lu, Shengyong; Yang, Jie; Du, Cuicui; Chen, Zhiliang; Buekens, Alfons; Yan, Jianhua

    2016-04-01

    In China, incineration is essential for reducing the volume of municipal solid waste arising in its numerous megacities. The evolution of incinerator capacity has been huge, yet it creates strong opposition from a small, but vocal part of the population. The characteristics of Chinese municipal solid waste are analysed and data presented on its calorific value and composition. These are not so favourable for incineration, since the sustained use of auxiliary fuel is necessary for ensuring adequate combustion temperatures. Also, the emission standard for acid gases is more lenient in China than in the European Union, so special attention should be paid to the issue of acidification arising from flue gas. Next, the techniques used in flue gas cleaning in China are reviewed and the acidification potential by cleaned flue gas is estimated. Still, acidification induced by municipal solid waste incinerators remains marginal compared with the effects of coal-fired power plants. PMID:26941208

  14. Epistemic uncertainties and natural hazard risk assessment - Part 1: A review of the issues

    NASA Astrophysics Data System (ADS)

    Beven, K. J.; Aspinall, W. P.; Bates, P. D.; Borgomeo, E.; Goda, K.; Hall, J. W.; Page, T.; Phillips, J. C.; Rougier, J. T.; Simpson, M.; Stephenson, D. B.; Smith, P. J.; Wagener, T.; Watson, M.

    2015-12-01

    Uncertainties in natural hazard risk assessment are generally dominated by the sources arising from lack of knowledge or understanding of the processes involved. There is a lack of knowledge about frequencies, process representations, parameters, present and future boundary conditions, consequences and impacts, and the meaning of observations in evaluating simulation models. These are the epistemic uncertainties that can be difficult to constrain, especially in terms of event or scenario probabilities, even as elicited probabilities rationalized on the basis of expert judgements. This paper reviews the issues raised by trying to quantify the effects of epistemic uncertainties. Such scientific uncertainties might have significant influence on decisions that are made for risk management, so it is important to communicate the meaning of an uncertainty estimate and to provide an audit trail of the assumptions on which it is based. Some suggestions for good practice in doing so are made.

  15. Human–environment interactions in urban green spaces — A systematic review of contemporary issues and prospects for future research

    SciTech Connect

    Kabisch, Nadja; Qureshi, Salman; Haase, Dagmar

    2015-01-15

    Scientific papers on landscape planning underline the importance of maintaining and developing green spaces because of their multiple environmental and social benefits for city residents. However, a general understanding of contemporary human–environment interaction issues in urban green space is still incomplete and lacks orientation for urban planners. This review examines 219 publications to (1) provide an overview of the current state of research on the relationship between humans and urban green space, (2) group the different research approaches by identifying the main research areas, methods, and target groups, and (3) highlight important future prospects in urban green space research. - Highlights: • Reviewed literature on urban green pins down a dearth of comparative studies. • Case studies in Africa and Russia are marginalized – the Europe and US dominate. • Questionnaires are used as major tool followed by GIS and quantitative approaches. • Developing countries should contribute in building an urban green space agenda. • Interdisciplinary, adaptable and pluralistic approaches can satiate a knowledge gap.

  16. Use of technology assessment databases to identify the issues associated with adoption of structural health monitoring practices.

    SciTech Connect

    Roach, Dennis Patrick; Smith, Bryce; Neidigk, Stephen

    2010-09-01

    The goal is to create a systematic method and structure to compile, organize, and summarize SHM related data to identify the level of maturity and rate of evolution and have a quick and ongoing evaluation of the current state of SHM among research institutions and industry. Hundreds of technical publication and conference proceedings were read and analyzed to compile the database. Microsoft Excel was used to create a useable interface that could be filtered to compare any of the entered data fields.

  17. Informed consent in psychiatry clinical research: A conceptual review of issues, challenges, and recommendations

    PubMed Central

    Gupta, Umesh Chandra; Kharawala, Saifuddin

    2012-01-01

    Obtaining informed consent in psychiatry clinical research involving subjects with diminished mental abilities and impaired consent capacity has been a challenge for researchers, posing many ethical concerns and procedural hurdles due to participants’ cognitive deficits and impaired ability to judge reality. Regulations seem inadequate and provide limited guidance, not sufficient to address all the ethical issues inherent in different situations related to obtaining consent from decisionally impaired persons. Researchers are struggling to find a balance between risk-benefit ratio, research advancement, and autonomy of study subjects. Inspired to improve the consent process in psychiatry clinical research, many studies have been conducted focusing on various informed consent-related ethical concerns, with the aim of developing appropriate strategies and optimizing the informed consent procedure in psychiatry clinical research, overcoming the ethical concerns. This article critically reviews the various ethical issues and consent challenges, their underlying reasons, and investigates the appropriate strategies and practices needed to be adopted while obtaining informed consent from subjects with impaired consent capacity, participating in psychiatry clinical research. PMID:22347696

  18. +Ophitoxaemia and myocardial infarction--the issues during primary angioplasty: a review.

    PubMed

    Gupta, Prabha Nini; Thomas, Jinesh; Francis, Preetham Kumar; Shylaja, Sajith Vamadevan

    2014-01-01

    'The Big four' are the most poisonous snakes in India, and especially in Kerala. These include the cobra, the viper, the krait and the sea snake. Most of the poisonous snakebites in India occur in Kerala. We believe there are only a few reports of myocardial infarction after snakebites and most of these are viper bites. We believe this is the second case of primary angioplasty for a snakebite. There are at least a few potential issues in performing a primary angioplasty in a snakebite case, namely (1) Is it a thrombus or a spasm? (2) Are the bleeding parameters deranged? Will the patient tolerate tirofiban and other glycoprotein (GB) 2b3a inhibitors? Will he develop dangerous bleeding due to the high dose of heparin needed? Further, would we save the patient from myocardial infarction only to lose him to renal failure, both due to the nephrotoxicity of the venom, the kidney being further damaged by the contrast media used for the angioplasty? We discuss all these issues as they crossed our mind, and hope it will help further treatment in others. We would like to review the available literature on these points and describe a recent case of ours. PMID:25342187

  19. Review of Cross-Cultural Issues Related to Quality of Life After Spinal Cord Injury

    PubMed Central

    Tate, Denise

    2014-01-01

    Quality of life (QOL) is a dynamic concept that means different things to different people, both in the general public and within the research community. Because of this, a common definition of QOL has been hard to achieve. This article reviews cross-cultural issues related to QOL research in spinal cord injury (SCI). Many factors influence QOL for persons with SCI, including observable and objective indicators and subjective self-report ones. The World Health Organization’s International Classification of Function, Disability and Health is used in this article as a framework to better understand how these factors may influence QOL. A number of important steps are summarized with respect to measurement issues in QOL. A comparison between data from 2 countries (United States and Brazil) using the International SCI QOL Basic Data Set shows similarities in scores and good reliability in the Brazilian sample. Substantial, significant correlations were observed among the SCI QOL Basic Data Set items and the WHOQOL-BREF within the US sample. The article ends with a set of recommendations for the development of cross-cultural measures of QOL for use in the SCI population. PMID:25484564

  20. Corrosion issues in joining lightweight materials: A review of the latest achievements

    NASA Astrophysics Data System (ADS)

    Montemor, M. F.

    2016-02-01

    Multimaterials assemblies and, in particular, assemblies made of lightweight components are of utmost relevance in many technical applications. These assemblies include multimetal, metal-polymer, metal-adhesive, and metal-composites combinations, among others. Presently, the transportation sector is looking for lighter materials that allow for reducing fuel consumption and the environmental footprint. Aluminum and magnesium alloys, as well as composites and polymers, are considered strategic for such purposes, and their joining in metal-metal or hybrid assemblies has been explored to develop lightweight components. These multimaterial assemblies are often exposed to aggressive environments in which moisture and aggressive species are present. Under these conditions corrosion phenomena are a major source of material failures. Depending on the nature of the metals and nonmetals and of the joining process, the mechanism and extent of corrosion can vary significantly. Thus, it is essential to understand the impact of corrosion in joined materials and to know which counter-measures can be adopted to mitigate corrosion events in the system of concern. This chapter aims at reviewing the latest results of studies focused in corrosion issues in the joining of lightweight materials. It describes the most common corrosion phenomena observed in joined materials, and it emphasizes corrosion issues in assemblies that combine different metals and that combine metals with nonmetals. Moreover, it overviews the state-of-the-art in corrosion protection strategies that can be applied and, finally, it overlooks the future trends.

  1. Using online reviews by restaurant patrons to identify unreported cases of foodborne illness - New York City, 2012-2013.

    PubMed

    Harrison, Cassandra; Jorder, Mohip; Stern, Henri; Stavinsky, Faina; Reddy, Vasudha; Hanson, Heather; Waechter, HaeNa; Lowe, Luther; Gravano, Luis; Balter, Sharon

    2014-05-23

    While investigating an outbreak of gastrointestinal disease associated with a restaurant, the New York City Department of Health and Mental Hygiene (DOHMH) noted that patrons had reported illnesses on the business review website Yelp (http://www.yelp.com) that had not been reported to DOHMH. To explore the potential of using Yelp to identify unreported outbreaks, DOHMH worked with Columbia University and Yelp on a pilot project to prospectively identify restaurant reviews on Yelp that referred to foodborne illness. During July 1, 2012-March 31, 2013, approximately 294,000 Yelp restaurant reviews were analyzed by a software program developed for the project. The program identified 893 reviews that required further evaluation by a foodborne disease epidemiologist. Of the 893 reviews, 499 (56%) described an event consistent with foodborne illness (e.g., patrons reported diarrhea or vomiting after their meal), and 468 of those described an illness within 4 weeks of the review or did not provide a period. Only 3% of the illnesses referred to in the 468 reviews had also been reported directly to DOHMH via telephone and online systems during the same period. Closer examination determined that 129 of the 468 reviews required further investigation, resulting in telephone interviews with 27 reviewers. From those 27 interviews, three previously unreported restaurant-related outbreaks linked to 16 illnesses met DOHMH outbreak investigation criteria; environmental investigation of the three restaurants identified multiple food-handling violations. The results suggest that online restaurant reviews might help to identify unreported outbreaks of foodborne illness and restaurants with deficiencies in food handling. However, investigating reports of illness in this manner might require considerable time and resources. PMID:24848215

  2. Analytical strategies used to identify the readers of histone modifications: A review.

    PubMed

    Wang, Ye; Han, Yanpu; Fan, Enguo; Zhang, Kai

    2015-09-01

    The so-called "readers" of histone post-translational modifications (HPTMs) refer to proteins or complexes that are recruited to HPTMs thus eventually regulate gene transcription. To identify these "readers", mass spectrometry plays an essential role following various enriching strategies. These enriching methods include the use of modified histone peptides/proteins or chemically synthesized histones/nucleosomes containing desired HPTMs to enrich the readers of HPTMs. Despite the peptide- or protein-based assay is straightforward and easy to perform for most labs, this strategy has limited applications for those weak or combinational interactions among various HPTMs and false-positive results are a potential big problem. While the results derived from synthesized histone proteins/nucleosomes is more reliable as it mimics the real chromatic conditions thus is able to analyze the binders of those cross-talked HPTMs, usually the synthesis is so difficult that their applications are impeded for high throughput analysis. In this review, an overview of these analytical techniques is provided and their advantages and disadvantages are discussed. PMID:26388362

  3. Identifying Effective Methods for Teaching Sex Education to Individuals With Intellectual Disabilities: A Systematic Review

    PubMed Central

    Schaafsma, Dilana; Kok, Gerjo; Stoffelen, Joke M. T.; Curfs, Leopold M. G.

    2015-01-01

    Sex education for individuals with intellectual disabilities is important. However, our knowledge about effective methods for teaching sex education to this population is limited. We report the results of a systematic review identifying methods for sex education programs aimed at individuals with intellectual disabilities. In all, 20 articles were included that met the criteria set in terms of topic—the effectiveness of sex education programs—and population of interest—individuals with intellectual disabilities. In these articles, methods for increasing knowledge and for improving skills and attitudes were reported. However, the studies revealed that generalization of skills to real-life situations was often not achieved. There are indications that the maintenance of knowledge and skills still needs extra attention. Moreover, detailed descriptions of the program materials, program goals, and methods used in the programs were often lacking in the reports. Although there is some evidence for methods that may improve knowledge, attitudes, and skills with regard to sex education aimed at individuals with intellectual disabilities, due to the lack of detailed descriptions provided it is unclear under which conditions these methods work. We therefore suggest that authors provide additional detail about methods in future publications or in online supplements. PMID:25085114

  4. Water resources and environmental input-output analysis and its key study issues: a review

    NASA Astrophysics Data System (ADS)

    YANG, Z.; Xu, X.

    2013-12-01

    Used to study the material and energy flow in socioeconomic system, Input-Output Analysis(IOA) had been an effective analysis tool since its appearance. The research fields of Input-Output Analysis were increasingly expanded and studied in depth with the development of fundamental theory. In this paper, starting with introduction of theory development, the water resources input-output analysis and environmental input-output analysis had been specifically reviewed, and two key study issues mentioned as well. Input-Occupancy-Output Analysis and Grey Input-Output Analysis whose proposal and development were introduced firstly could be regard as the effective complements of traditional IOA theory. Because of the hypotheses of homogeneity, stability and proportionality, Input-Occupancy-Output Analysis and Grey Input-Output Analysis always had been restricted in practical application inevitably. In the applied study aspect, with investigation of abundant literatures, research of water resources input-output analysis and environmental input-output analysis had been comprehensively reviewed and analyzed. The regional water resources flow between different economic sectors had been systematically analyzed and stated, and several types of environmental input-output analysis models combined with other effective analysis tools concluded. In two perspectives in terms of external and inland aspect, the development of water resources and environmental input-output analysis model had been explained, and several typical study cases in recent years listed respectively. By the aid of sufficient literature analysis, the internal development tendency and study hotspot had also been summarized. In recent years, Chinese literatures reporting water resources consumption analysis and virtue water study had occupied a large share. Water resources consumption analysis had always been the emphasis of inland water resources IOA. Virtue water study had been considered as the new hotspot of

  5. Microalgae biofuels: A critical review of issues, problems and the way forward.

    PubMed

    Lam, Man Kee; Lee, Keat Teong

    2012-01-01

    Culturing of microalgae as an alternative feedstock for biofuel production has received a lot of attention in recent years due to their fast growth rate and ability to accumulate high quantity of lipid and carbohydrate inside their cells for biodiesel and bioethanol production, respectively. In addition, this superior feedstock offers several environmental benefits, such as effective land utilization, CO(2) sequestration, self-purification if coupled with wastewater treatment and does not trigger food versus fuel feud. Despite having all these 'theoretical' advantages, review on problems and issues related to energy balance in microalgae biofuel are not clearly addressed until now. Base on the maturity of current technology, the true potential of microalgae biofuel towards energy security and its feasibility for commercialization are still questionable. Thus, this review is aimed to depict the practical problems that are facing the microalgae biofuel industry, covering upstream to downstream activities by accessing the latest research reports and critical data analysis. Apart from that, several interlink solutions to the problems will be suggested with the purpose to bring current microalgae biofuel research into a new dimension and consequently, to revolutionize the entire microalgae biofuel industry towards long-term sustainability. PMID:22166620

  6. Mental health issues among pregnant women in correctional facilities: a systematic review.

    PubMed

    Mukherjee, Soumyadeep; Pierre-Victor, Dudith; Bahelah, Raed; Madhivanan, Purnima

    2014-01-01

    Incarceration-induced stress makes pregnant women in correctional facilities a high-risk group for mental health problems, resulting in adverse maternal and fetal outcomes. A systematic review was conducted to examine the prevalence and correlates of mental health issues among pregnant inmates. Databases searched included PubMed, Medline, CINAHL Plus, PsycINFO, National Criminal Justice Reference System, Social Work Abstracts, Cochrane and Campbell libraries, which were searched for studies published in English from 1950 till July 2013. Eleven studies were included of pregnant women in correctional facilities and addressed at least one mental illness. Quality score was assigned to these eligible articles. Due to heterogeneity, a narrative review was performed. All of the studies were conducted in the United States, with quality scores ranging from 7 to 10 out of 10. Only one of these studies used mixed methods, the rest were quantitative. Tobacco use among pregnant inmates exceeded 50%, with some studies reporting as high as 84%. Alcohol use was common; 36% of the inmates used illicit drugs in one study. Depression and anxiety levels were high-some studies reported depression among 80% of inmates. Findings suggest that mental health among pregnant prisoners is a huge concern that has not been adequately addressed. PMID:25190332

  7. Ethical Issues Raised by Private Practice Physiotherapy Are More Diverse than First Meets the Eye: Recommendations from a Literature Review

    PubMed Central

    Drolet, Marie-Josée; Williams-Jones, Bryn

    2015-01-01

    ABSTRACT Purpose: Physiotherapy in private practice differs from physiotherapy practised in a public setting in several ways, the most evident of which is the for-profit nature of private physiotherapy clinics; these differences can generate distinct and challenging ethical issues. The objectives of this article are to identify ethical issues encountered by physiotherapists in private practice settings and to identify potential solutions and recommendations to address these issues. Method: After a literature search of eight databases, 39 studies addressing ethical issues in a private practice context were analyzed. Results: A total of 25 ethical issues emerging from the included studies were classified into three main categories: (1) business and economic issues (e.g., conflicts of interests, inequity in a managed care context, lack of time affecting quality of care); (2) professional issues (e.g., professional autonomy, clinical judgment, treatment effectiveness, professional conduct); and (3) patients' rights and welfare issues (e.g., confidentiality, power asymmetries, paternalism vs. patient autonomy, informed consent). Recommendations as to how physiotherapists could better manage these issues were then identified and categorized. Conclusions: The physiotherapy community should reflect on the challenges raised by private practice so that professionals can be supported—through education, research, and good governance—in providing the best possible care for their patients. PMID:25931663

  8. Identifying circulating microRNAs as biomarkers of cardiovascular disease: a systematic review

    PubMed Central

    Navickas, Rokas; Gal, Diane; Laucevičius, Aleksandras; Taparauskaitė, Agnė; Zdanytė, Monika; Holvoet, Paul

    2016-01-01

    The aim of the present study is to identify microRNAs (miRs) with high potential to be used as biomarkers in plasma and/or serum to clinically diagnose, or provide accurate prognosis for survival in, patients with atherosclerosis, coronary artery disease, and acute coronary syndrome (ACS). A systematic search of published original research yielded a total of 72 studies. After review of the risk of bias of the published studies, according to Cochrane Collaboration and the QUADUAS Group standards, 19 studies were selected. Overall 52 different miRs were reported. In particular, miR-133a/b (5 studies), miR-208a/b (6 studies), and miR-499 (7 studies) were well studied and found to be significant diagnostic and/or prognostic markers across different cardiovascular disease progression stages. miR-1 and miR-145b are potential biomarkers of ACS; miR-1 with higher sensitivity for all acute myocardial infarction (AMI), and miR-145 for STEMI and worse outcome of AMI. But when miRs were studied across different ACS study populations, patients had varying degrees of coronary stenosis, which was identified as an important confounder that limited the ability to quantitatively pool the study results. The identified miRs were found to regulate endothelial function and angiogenesis (miR-1, miR-133), vascular smooth muscle cell differentiation (miR-133, miR-145), communication between vascular smooth muscle and endothelial cell to stabilize plaques (miR-145), apoptosis (miR-1, miR-133, miR-499), cardiac myocyte differentiation (miR-1, miR-133, miR-145, miR-208, miR-499), and to repress cardiac hypertrophy (miR-133). Their role in these processes may be explained by regulation of shared RNA targets such as cyclin-dependent kinase inhibitor 1A (or p21), ETS proto-oncogene 1, fascin actin-bundling protein 1, hyperpolarization-activated cyclic nucleotide-gated potassium channel 4, insulin-like growth factor 1 receptor LIM and SH3 protein 1, purine nucleoside phosphorylase, and transgelin

  9. Identifying circulating microRNAs as biomarkers of cardiovascular disease: a systematic review.

    PubMed

    Navickas, Rokas; Gal, Diane; Laucevičius, Aleksandras; Taparauskaitė, Agnė; Zdanytė, Monika; Holvoet, Paul

    2016-09-01

    The aim of the present study is to identify microRNAs (miRs) with high potential to be used as biomarkers in plasma and/or serum to clinically diagnose, or provide accurate prognosis for survival in, patients with atherosclerosis, coronary artery disease, and acute coronary syndrome (ACS). A systematic search of published original research yielded a total of 72 studies. After review of the risk of bias of the published studies, according to Cochrane Collaboration and the QUADUAS Group standards, 19 studies were selected. Overall 52 different miRs were reported. In particular, miR-133a/b (5 studies), miR-208a/b (6 studies), and miR-499 (7 studies) were well studied and found to be significant diagnostic and/or prognostic markers across different cardiovascular disease progression stages. miR-1 and miR-145b are potential biomarkers of ACS; miR-1 with higher sensitivity for all acute myocardial infarction (AMI), and miR-145 for STEMI and worse outcome of AMI. But when miRs were studied across different ACS study populations, patients had varying degrees of coronary stenosis, which was identified as an important confounder that limited the ability to quantitatively pool the study results. The identified miRs were found to regulate endothelial function and angiogenesis (miR-1, miR-133), vascular smooth muscle cell differentiation (miR-133, miR-145), communication between vascular smooth muscle and endothelial cell to stabilize plaques (miR-145), apoptosis (miR-1, miR-133, miR-499), cardiac myocyte differentiation (miR-1, miR-133, miR-145, miR-208, miR-499), and to repress cardiac hypertrophy (miR-133). Their role in these processes may be explained by regulation of shared RNA targets such as cyclin-dependent kinase inhibitor 1A (or p21), ETS proto-oncogene 1, fascin actin-bundling protein 1, hyperpolarization-activated cyclic nucleotide-gated potassium channel 4, insulin-like growth factor 1 receptor LIM and SH3 protein 1, purine nucleoside phosphorylase, and transgelin

  10. Bladder Cancer in HIV-infected Adults: An Emerging Issue? Case-Reports and Systematic Review

    PubMed Central

    Chawki, Sylvain; Ploussard, Guillaume; Montlahuc, Claire; Verine, Jérome; Mongiat-Artus, Pierre; Desgrandchamps, François; Molina, Jean-Michel

    2015-01-01

    Objectives Non-AIDS-related malignancies now represent a frequent cause of death among HIV-infected patients. Albeit bladder cancer is one of the most common malignancies worldwide, it has been rarely reported among HIV-infected patients. We wished to assess the prevalence and characteristics of bladder cancer in HIV-infected patients. Methods We conducted a single center retrospective study from 1998 to 2013 in a university hospital in Paris. Cases of bladder cancer among HIV-infected patients were identified using the electronic records of the hospital database and of the HIV-infected cohort. Patient characteristics and outcomes were retrieved from patients charts. A systematic review of published cases of bladder cancers in patients with HIV-infection was also performed. Results During the study period we identified 15 HIV-infected patients (0.2% of the cohort) with a bladder cancer. Patients were mostly men (73%) and smokers (67%), with a median age of 56 years at cancer diagnosis. Bladder cancer was diagnosed a median of 14 years after HIV-infection. Most patients were on ART (86%) with median current and nadir CD4 cell counts of 506 and 195 cells/mm3, respectively. Haematuria (73%) was the most frequent presenting symptom and HPV-associated lesions were seen in 6/10 (60%) patients. Histopathology showed transitional cell carcinoma in 80% and a high proportion of tumors with muscle invasion (47%) and high histologic grade (73%). One-year survival rate was 74.6%. The systematic review identified 13 additional cases of urothelial bladder cancers which shared similar features. Conclusions Bladder cancers in HIV-infected patients remain rare but may occur in relatively young patients with a low nadir CD4 cell count, have aggressive pathological features and can be fatal. PMID:26642314

  11. Space Shuttle Orbiter corrosion history, 1981-1993: A review and analysis of issues involving structures and subsystems

    NASA Technical Reports Server (NTRS)

    1995-01-01

    This report summarizes past corrosion issues experienced by the NASA space shuttle orbiter fleet. Design considerations for corrosion prevention and inspection methods are reviewed. Significant corrosion issues involving structures and subsystems are analyzed, including corrective actions taken. Notable successes and failures of corrosion mitigation systems and procedures are discussed. The projected operating environment used for design is contrasted with current conditions in flight and conditions during ground processing.

  12. A review of quality of life in Alzheimer's disease. Part 2: Issues in assessing drug effects.

    PubMed

    Salek, S S; Walker, M D; Bayer, A J

    1998-12-01

    There are numerous methods available for assessing patients with Alzheimer's disease (AD) or other forms of dementia. Quality-of-life (QOL) assessment is unique among these methods. The subjective nature of quality of life provides healthcare professionals with the opportunity of incorporating the value systems of patients and their carers into their assessments. A systematic review was carried out to assess the published data (and some unpublished data) on QOL assessment tools and instruments that claim to measure quality of life in dementia. A number of measures or methods used in the literature for assessing the quality of life of patients with dementing illnesses were identified. It was decided to present the resultant review in 2 parts that correspond to the 2 main groups into which the instruments were categorised. The first (part 1), looked at measures used to assess the impact of disease as well as instruments at a developmental or testing stage. The second (part 2), includes instruments that claim to measure quality of life in studies documenting the impact of a drug in this therapeutic area. This second group consists mainly of instruments identified as being used to assess quality of life during clinical trials in dementia/AD. As in part 1, this part of the review was unable to identify any validated methods of assessing the quality of life of both patients with dementia and their carers at the same time. The ideal instrument must show that it can reliably, reproducibly and comprehensively assess quality of life for both patients with dementia and their carers. It should also demonstrate that it can measure quality of life effectively using a practical administration technique that does not place any unnecessary burden on either informal carers, other healthcare workers involved or the patient themselves. In addition, any measure intended for use in assessing the impact of drug treatment on quality of life must demonstrate sensitivity to change, also

  13. A review of gay, lesbian, bisexual, and transgender youth issues for the pediatrician.

    PubMed

    Steever, John B; Cooper-Serber, Emma

    2013-02-01

    CME EDUCATIONAL OBJECTIVES: 1.Review common gay, lesbian, bisexual, and transgender (GLBT) terminology and discuss sexual constructs as they are currently understood.2.Determine the prevalence of GLBT youth and identify health disparities in the GLBT population.3.Provide strategies to develop an accepting atmosphere for GLBT youth in the pediatric practice, including the maintenance of ongoing health and appropriate screening for at-risk behaviors. Gay, lesbian, bisexual, and transgendered individuals have always been present in human society.1,2 References to same-sex couples and activity have been noted as far back as 600 B.C. on ancient Japanese and Chinese pottery. Ancient Greek and Roman art is full of depictions of same-sex couples; some scholars believe that Alexander the Great was gay.3. PMID:23379402

  14. A brief review on relaxor ferroelectrics and selected issues in lead-free relaxors

    NASA Astrophysics Data System (ADS)

    Ahn, Chang Won; Hong, Chang-Hyo; Choi, Byung-Yul; Kim, Hwang-Pill; Han, Hyoung-Su; Hwang, Younghun; Jo, Wook; Wang, Ke; Li, Jing-Feng; Lee, Jae-Shin; Kim, Ill Won

    2016-06-01

    Relaxor ferroelectricity is one of the most widely investigated but the least understood material classes in the condensed matter physics. This is largely due to the lack of experimental tools that decisively confirm the existing theoretical models. In spite of the diversity in the models, they share the core idea that the observed features in relaxors are closely related to localized chemical heterogeneity. Given this, this review attempts to overview the existing models of importance chronologically, from the diffuse phase transition model to the random-field model and to show how the core idea has been reflected in them to better shape our insight into the nature of relaxor-related phenomena. Then, the discussion will be directed to how the models of a common consensus, developed with the so-called canonical relaxors such as Pb(Mg1/3Nb2/3)O3 (PMN) and (Pb, La)(Zr, Ti)O3 (PLZT), are compatible with phenomenological explanations for the recently identified relaxors such as (Bi1/2Na1/2)TiO3 (BNT)-based lead-free ferroelectrics. This review will be finalized with a discussion on the theoretical aspects of recently introduced 0-3 and 2-2 ferroelectric/relaxor composites as a practical tool for strain engineering.

  15. 42 CFR 405.1104 - Request for MAC review when an ALJ does not issue a decision timely.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Request for MAC review when an ALJ does not issue a... under § 405.1016 may request MAC review if— (1) The appellant files a written request with the ALJ to... escalation or 5 calendar days from the end of the applicable adjudication period set forth in § 405.1016....

  16. Liposome Delivery Systems for Inhalation: A Critical Review Highlighting Formulation Issues and Anticancer Applications.

    PubMed

    Rudokas, Mindaugas; Najlah, Mohammad; Alhnan, Mohamed Albed; Elhissi, Abdelbary

    2016-01-01

    This is a critical review on research conducted in the field of pulmonary delivery of liposomes. Issues relating to the mechanism of nebulisation and liposome composition were appraised and correlated with literature reports of liposome formulations used in clinical trials to understand the role of liposome size and composition on therapeutic outcome. A major highlight was liposome inhalation for the treatment of lung cancers. Many in vivo studies that explored the potential of liposomes as anticancer carrier systems were evaluated, including animal studies and clinical trials. Liposomes can entrap anticancer drugs and localise their action in the lung following pulmonary delivery. The safety of inhaled liposomes incorporating anticancer drugs depends on the anticancer agent used and the amount of drug delivered to the target cancer in the lung. The difficulty of efficient targeting of liposomal anticancer aerosols to the cancerous tissues within the lung may result in low doses reaching the target site. Overall, following the success of liposomes as inhalable carriers in the treatment of lung infections, it is expected that more focus from research and development will be given to designing inhalable liposome carriers for the treatment of other lung diseases, including pulmonary cancers. The successful development of anticancer liposomes for inhalation may depend on the future development of effective aerosolisation devices and better targeted liposomes to maximise the benefit of therapy and reduce the potential for local and systemic adverse effects. PMID:26938856

  17. Clinical review: Balancing the therapeutic, safety, and economic issues underlying effective antipseudomonal carbapenem use

    PubMed Central

    Slama, Thomas G

    2008-01-01

    Antipseudomonal carbapenems have played a useful role in our antimicrobial armamentarium for 20 years. However, a review of their use during that period creates concern that their clinical effectiveness is critically dependent on attainment of an appropriate dosing range. Unfortunately, adequate carbapenem dosing is missed for many reasons, including benefit/risk misconceptions, a narrow therapeutic window for imipenem and meropenem (due to an increased rate of seizures at higher doses), increasingly resistant pathogens requiring higher doses than are typically given, and cost containment issues that may limit their use. To improve the use of carbapenems, several initiatives should be considered: increase awareness about appropriate treatment with carbapenems across hospital departments; determine optimal dosing regimens for settings where multidrug resistant organisms are more likely encountered; use of, or combination with, an alternative antimicrobial agent having more favorable pharmacokinetic, pharmacodynamic, or adverse event profile; and administer a newer carbapenem with lower propensity for resistance development (for example, reduced expression of efflux pumps or greater stability against carbapenemases). PMID:18983709

  18. In vivo X-ray fluorescence of lead in bone: review and current issues.

    PubMed Central

    Todd, A C; Chettle, D R

    1994-01-01

    Bone lead measurements can assess long-term lead dosimetry because the residence time of lead in bone is long. Bone lead measurements thus complement blood and plasma lead measurements, which reflect more short-term exposure. Although the noninvasive, in vivo measurement of lead in bone by X-ray fluorescence (XRF) has been under development since the 1970s, its use is still largely confined to research institutions. There are three principal methods used that vary both in the how lead X-rays are fluoresced and in which lead X-rays are fluoresced. Several groups have reported the independent development of in vivo measurement systems, the majority adopting the 109Cd K XRF method because of its advantages: a robust measurement, a lower detection limit (compared to 57Co K XRF), and a lower effective (radiation) dose (compared to L XRF) when calculated according to the most recent guidelines. These advantages, and the subsequent widespread adoption of the 109Cd method, are primarily consequences of the physics principles of the technique. This paper presents an explanation of the principles of XRF, a description of the practical measurement systems, a review of the human bone lead studies performed to date; and a discussion of some issues surrounding future application of the methods. Images p172-a PMID:8033846

  19. Psychiatric morbidity following motor vehicle accidents: a review of methodological issues.

    PubMed

    Blaszczynski, A; Gordon, K; Silove, D; Sloane, D; Hillman, K; Panasetis, P

    1998-01-01

    Motor vehicle accidents (MVAs), even those of a nonserious nature, appear to increase the risk of severe psychiatric morbidity in survivors. The present review examines the evidence indicating the levels of psychiatric morbidity in MVA survivors. Although no consistent profile has emerged, the most commonly reported symptoms are depression, anxiety, irritability, driving phobia, anger, sleep disturbances, and headache, with rates of posttraumatic stress disorder (PTSD) across studies of 0% to 100%. Variability in the type and severity of psychiatric outcomes may be due, in part, to methodological inadequacies in many studies, particularly the use of biased population samples, inclusion of subjects exposed to varied types of accidents, an absence of a clear definition of PTSD, a reliance on clinical judgment rather than the use of objective psychometric measures, the failure to include ratings of injury severity, and the absence of assessments for past exposure to traumatic events or preexisting posttraumatic reactions. The most important concern relates to the use of nonrepresentative samples, usually patients referred for medicolegal assessment in whom issues of compensation are of central importance. Gender and age differences distinguish the compensation group from the general population of MVA survivors, who therefore may also differ in the vulnerability to posttraumatic morbidity. It is argued that more systematic research on unselected subject samples is critical to establish epidemiological data on the true nature and extent of psychiatric morbidity following MVAs. PMID:9606576

  20. Xylitol: a review on bioproduction, application, health benefits, and related safety issues.

    PubMed

    Ur-Rehman, Salim; Mushtaq, Zarina; Zahoor, Tahir; Jamil, Amir; Murtaza, Mian Anjum

    2015-01-01

    Xylitol is a pentahydroxy sugar-alcohol which exists in a very low quantity in fruits and vegetables (plums, strawberries, cauliflower, and pumpkin). On commercial scale, xylitol can be produced by chemical and biotechnological processes. Chemical production is costly and extensive in purification steps. However, biotechnological method utilizes agricultural and forestry wastes which offer the possibilities of economic production of xylitol by reducing required energy. The precursor xylose is produced from agricultural biomass by chemical and enzymatic hydrolysis and can be converted to xylitol primarily by yeast strain. Hydrolysis under acidic condition is the more commonly used practice influenced by various process parameters. Various fermentation process inhibitors are produced during chemical hydrolysis that reduce xylitol production, a detoxification step is, therefore, necessary. Biotechnological xylitol production is an integral process of microbial species belonging to Candida genus which is influenced by various process parameters such as pH, temperature, time, nitrogen source, and yeast extract level. Xylitol has application and potential for food and pharmaceutical industries. It is a functional sweetener as it has prebiotic effects which can reduce blood glucose, triglyceride, and cholesterol level. This review describes recent research developments related to bioproduction of xylitol from agricultural wastes, application, health, and safety issues. PMID:24915309

  1. Identifying Opportunities for Virtual Reality Simulation in Surgical Education: A Review of the Proceedings from the Innovation, Design, and Emerging Alliances in Surgery (IDEAS) Conference: VR Surgery

    PubMed Central

    Olasky, Jaisa; Sankaranarayanan, Ganesh; Seymour, Neal E.; Magee, J. Harvey; Enquobahrie, Andinet; Lin, Ming C.; Aggarwal, Rajesh; Brunt, L. Michael; Schwaitzberg, Steven D.; Cao, Caroline G. L.; De, Suvranu; Jones, Daniel B.

    2015-01-01

    Objectives To conduct a review of the state of virtual reality (VR) simulation technology, to identify areas of surgical education that have the greatest potential to benefit from it, and to identify challenges to implementation. Background Data Simulation is an increasingly important part of surgical training. VR is a developing platform for using simulation to teach technical skills, behavioral skills, and entire procedures to trainees and practicing surgeons worldwide. Questions exist regarding the science behind the technology and most effective usage of VR simulation. A symposium was held to address these issues. Methods Engineers, educators, and surgeons held a conference in November 2013 both to review the background science behind simulation technology and to create guidelines for its use in teaching and credentialing trainees and surgeons in practice. Results Several technologic challenges were identified that must be overcome in order for VR simulation to be useful in surgery. Specific areas of student, resident, and practicing surgeon training and testing that would likely benefit from VR were identified: technical skills, team training and decision-making skills, and patient safety, such as in use of electrosurgical equipment. Conclusions VR simulation has the potential to become an essential piece of surgical education curriculum but depends heavily on the establishment of an agreed upon set of goals. Researchers and clinicians must collaborate to allocate funding toward projects that help achieve these goals. The recommendations outlined here should guide further study and implementation of VR simulation. PMID:25925424

  2. A reassessment of the potential for an alpha-mode containment failure and a review of the current understanding of broader fuel-coolant interaction issues. Second steam explosion review group workshop

    SciTech Connect

    Basu, S.; Ginsberg, T.

    1996-08-01

    This report summarizes the review and evaluation by experts of the current understanding of the molten fuel-coolant interaction (FCI) issues covering the complete spectrum of interactions, i.e., from mild quenching to very energetic interactions including those that could lead to the alpha-mode containment failure. Of the eleven experts polled, all but two concluded that the alpha-mode failure issue was resolved from a risk perspective, meaning that this mode of failure is of very low probability, that it is of little or no significance to the overall risk from a nuclear power plant, and that any further reduction in residual uncertainties is not likely to change the probability in an appreciable manner. To a lesser degree, discussions also took place on the broader FCI issues such as mild quenching of core melt during non-explosive FCI, and shock loading of lower head and ex-vessel support structures arising from explosive localized FCIs. These latter issues are relevant with regard to determining the efficacy of certain accident management strategies for operating reactors as well as for advanced light water reactors. The experts reviewed the status of understanding of the FCI phenomena in the context of these broader issues, identified residual uncertainties in the understanding, and recommended future research (both experimental and analytical) to reduce the uncertainties.

  3. Neurobehavioral Deficits and Parkinsonism in Occupations with Manganese Exposure: A Review of Methodological Issues in the Epidemiological Literature

    PubMed Central

    Park, Robert M.

    2013-01-01

    Exposure to manganese (Mn) is associated with neurobehavioral effects. There is disagreement on whether commonly occurring exposures in welding, ferroalloy, and other industrial processes produce neurologically significant neurobehavioral changes representing parkinsonism. A review of methodological issues in the human epidemiological literature on Mn identified: (1) studies focused on idiopathic Parkinson disease without considering manganism, a parkinsonian syndrome; (2) studies with healthy worker effect bias; (3) studies with problematic statistical modeling; and (4) studies arising from case series derived from litigation. Investigations with adequate study design and exposure assessment revealed consistent neurobehavioral effects and attributable subclinical and clinical signs and symptoms of impairment. Twenty-eight studies show an exposure-response relationship between Mn and neurobehavioral effects, including 11 with continuous exposure metrics and six with three or four levels of contrasted exposure. The effects of sustained low-concentration exposures to Mn are consistent with the manifestations of early manganism, i.e., consistent with parkinsonism. This is compelling evidence that Mn is a neurotoxic chemical and there is good evidence that Mn exposures far below the current US standard of 5.0 mg/m3 are causing impairment. PMID:24106642

  4. Protocol for a Systematic Review of Telehealth Privacy and Security Research to Identify Best Practices.

    PubMed

    Watzlaf, Valerie J M; Dealmeida, Dilhari R; Zhou, Leming; Hartman, Linda M

    2015-01-01

    Healthcare professionals engaged in telehealth are faced with complex US federal regulations (e.g., HIPAA/HITECH) and could benefit from the guidance provided by best practices in Privacy and Security (P&S). This article describes a systematic review protocol to address this need. The protocol described herein uses the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The PRISMA-P contains 17 items that are considered essential, as well as minimum components to include in systematic reviews. PICOS (participants, interventions, comparisons, outcome(s) and study design of the systematic review) are also relevant to the development of best practices in P&S in telehealth systems. A systematic process can best determine what information should be included and how this information should be retrieved, condensed, analyzed, organized, and disseminated. PMID:27563383

  5. Protocol for a Systematic Review of Telehealth Privacy and Security Research to Identify Best Practices

    PubMed Central

    WATZLAF, VALERIE J.M.; DEALMEIDA, DILHARI R.; ZHOU, LEMING; HARTMAN, LINDA M.

    2015-01-01

    Healthcare professionals engaged in telehealth are faced with complex US federal regulations (e.g., HIPAA/HITECH) and could benefit from the guidance provided by best practices in Privacy and Security (P&S). This article describes a systematic review protocol to address this need. The protocol described herein uses the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The PRISMA-P contains 17 items that are considered essential, as well as minimum components to include in systematic reviews. PICOS (participants, interventions, comparisons, outcome(s) and study design of the systematic review) are also relevant to the development of best practices in P&S in telehealth systems. A systematic process can best determine what information should be included and how this information should be retrieved, condensed, analyzed, organized, and disseminated. PMID:27563383

  6. EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (External Review Draft)

    EPA Science Inventory

  1. Using Community-Based Participatory Research to Identify Environmental Justice Issues in an Inner-City Community and Inform Urban Planning.

    PubMed

    Mansyur, Carol Leler; Jeng, Hueiwang Anna; Holloman, Erica; DeBrew, Linwood

    2016-01-01

    The Southeast CARE Coalition has been using community-based participatory research to examine environmental degradation in the Southeast Community, Newport News, Virginia. A survey was developed to collect assessment data. Up to 66% of respondents were concerned about environmental problems in their community. Those with health conditions were significantly more likely to identify specific environmental problems. The top 5 environmental concerns included coal dust, air quality, crime, water quality, and trash. The community-based participatory research process is building community capacity and participation, providing community input into strategic planning, and empowering community members to take control of environmental justice issues in their community. PMID:27214672

  2. Behavioral Issues Associated With Long Duration Space Expeditions: Review and Analysis of Astronaut Journals

    NASA Technical Reports Server (NTRS)

    Struster, Jack

    2010-01-01

    Personal journals maintained by NASA astronauts during six-month expeditions onboard the International Space Station were analyzed to obtain information concerning a wide range of behavioral and human factors issues. Astronauts wrote most about their work, followed by outside communications (with mission control, family, and friends), adjustment to the conditions, interactions with crew mates, recreation/leisure, equipment (installation, maintenance), events (launches, docking, hurricanes, etc.), organization/management, sleep, and food. The study found evidence of a decline in morale during the third quarters of the missions and identified key factors that contribute to sustained adjustment and optimal performance during long-duration space expeditions. Astronauts reported that they benefited personally from writing in their journals because it helped maintain perspective on their work and relations with others. Responses to questions asked before, during, and after the expeditions show that living and working onboard the ISS is not as difficult as the astronauts anticipate before starting their six-month tours of duty. Recommendations include application of study results and continuation of the experiment to obtain additional data as crew size increases and operations evolve.

  3. Cumulative risk assessment lessons learned: a review of case studies and issue papers.

    PubMed

    Gallagher, Sarah S; Rice, Glenn E; Scarano, Louis J; Teuschler, Linda K; Bollweg, George; Martin, Lawrence

    2015-02-01

    Cumulative risk assessments (CRAs) examine potential risks posed by exposure to multiple and sometimes disparate environmental stressors. CRAs are more resource intensive than single chemical assessments, and pose additional challenges and sources of uncertainty. CRAs may examine the impact of several factors on risk, including exposure magnitude and timing, chemical mixture composition, as well as physical, biological, or psychosocial stressors. CRAs are meant to increase the relevance of risk assessments, providing decision makers with information based on real world exposure scenarios that improve the characterization of actual risks and hazards. The U.S. Environmental Protection Agency has evaluated a number of CRAs, performed by or commissioned for the Agency, to seek insight into CRA concepts, methods, and lessons learned. In this article, ten case studies and five issue papers on key CRA topics are examined and a set of lessons learned are identified for CRA implementation. The lessons address the iterative nature of CRAs, importance of considering vulnerability, need for stakeholder engagement, value of a tiered approach, new methods to assess multiroute exposures to chemical mixtures, and the impact of geographical scale on approach and purpose. PMID:25462315

  4. Phenotypic spectrum of mosaic trisomy 18: two new patients, a literature review, and counseling issues.

    PubMed

    Tucker, Megan E; Garringer, Holly J; Weaver, David D

    2007-03-01

    Mosaic trisomy 18 occurs when two different cell lines exist in the same individual; one cell line has two copies of chromosome 18, while the other has three copies. Here we present two new patients with mosaic trisomy 18, summarize 31 reported cases from the literature, and discuss management and counseling themes. Our first patient is an 8(1/2)-year-old female with normal intelligence and no significant dysmorphic features other than short stature and cubitus valgus. The second patient is a 21-month-old male with developmental delay, several dysmorphic features, including a patent ductus arteriosus, and normal growth. In general, the phenotype of individuals with mosaic trisomy 18 varies greatly. Some individuals have the complete trisomy 18, Edwards syndrome phenotype with early death while others are phenotypically completely normal. The latter group is exemplified by four normal appearing adults with mosaic trisomy 18 who were identified only after giving birth to children with complete trisomy 18. Further, a wide range of anomalies have been reported, most at low frequencies, including microcephaly, delayed bone age, brachydactyly, congenital heart defects, developmental delay, short stature, and premature ovarian failure. Intellectual capabilities range from profound mental retardation to above average intelligence. There appears to be no correlation with the percentage of trisomic cells in either fibroblasts or leukocytes and the individual's phenotype or intellectual function. We also discuss a variety of counseling issues including long-term survival, reproductive capacity of individuals with mosaic trisomy 18, and recurrence risks. PMID:17266111

  5. 42 CFR 137.301 - How are project and program environmental review costs identified?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE... development to identify program and project related costs associated with carrying out environmental responsibilities for proposed projects. The goal in this process is to identify the costs associated with...

  6. Stress in Female-Identified Transgender Youth: A Review of the Literature on Effects and Interventions

    ERIC Educational Resources Information Center

    Ignatavicius, Stephanie

    2013-01-01

    Female-identified transgender youth (FIT youth) have a male birth sex but identify as female, placing them outside of socially acceptable standards and increasing the challenges of adolescence. They face numerous potential sources of stress and have a higher likelihood of experiencing negative mental health outcomes due to lack of support, lack of…

  7. A Review of Elementary School-Based Substance Use Prevention Programs: Identifying Program Attributes

    ERIC Educational Resources Information Center

    Hopfer, S.; Davis, D.; Kam, J. A.; Shin, Y.; Elek, E.; Hecht, M. L.

    2010-01-01

    This article takes a systematic approach to reviewing substance use prevention programs introduced in elementary school (K-6th grade). Previous studies evaluating such programs among elementary school students showed mixed effects on subsequent substance use and related psychosocial factors. Thirty published evaluation studies of 24 elementary…

  8. Identifying the Potential Organizational Impact of an Educational Peer Review Program

    ERIC Educational Resources Information Center

    Toth, Kate E.; McKey, Colleen A.

    2010-01-01

    The literature on educational peer review (EPR) has focused on evaluating EPR's impact on faculty and/or student learning outcomes; no literature exists on the potential organizational impact. A qualitative (case study) research design explored perceptions of 17 faculty and 10 administrators within a school of nursing in an Ontario university…

  9. Using systematic reviews for evidence-based health promotion: basic methodology issues.

    PubMed

    Buendía-Rodríguez, Jefferson A; Sánchez-Villamil, Juana P

    2006-12-01

    Systematic reviews and evidence-based recommendations are becoming increasingly important for decision-making in health and medicine. Systematic reviews of population-health interventions are challenging and methods will continue evolving. This paper provides an overview of how evidence-based approaches in public health and health promotion are being reviewed to provide a basis for Colombian Guide to Health Promotion, analysing limitations and recommendations for future reviews. PMID:17361581

  10. Periodic Judicial Review of Children in Foster Care: Issues Related to Effective Implementation.

    ERIC Educational Resources Information Center

    Davidson, Howard A.

    In 1974, the National Council of Juvenile and Family Court Judges initiated a special project to promote, in courts throughout the country, periodic review of the status of all children in foster care. This paper explains the development of these judicial review systems, describes several alternative review mechanisms, and discusses key issues…

  11. Issues of Cultural Appropriateness and Pedagogical Efficacy: Exploring Peer Review in a Second Language Writing Class

    ERIC Educational Resources Information Center

    Hu, Guangwei; Lam, Sandra Tsui Eu

    2010-01-01

    This paper reports on a study designed to investigate (a) whether peer review is an effective pedagogical activity with adult Chinese students in the teaching of second language (L2) academic writing and (b) how factors such as perceptions of the influence of peer reviewers' L2 proficiency, previous experience with peer review, feedback…

  12. Reviewing the Verdict: Issues of the Police, Justice, Change [and] Instructor's Guide.

    ERIC Educational Resources Information Center

    Croddy, Marshall

    This document consists of a study unit and an accompanying teacher's guide prepared to assist teachers and community groups in discussing some of the legal and constitutional issues raised by the verdict in the Rodney King beating case. The study unit's first section, "Trial and Verdict," examines such issues as the public perceptions of the state…

  13. Race and Ethnicity: Issues for Adolescents with Chronic Illnesses and Disabilities. Cydline Reviews.

    ERIC Educational Resources Information Center

    Minnesota Univ., Minneapolis. National Center for Youth with Disabilities.

    This abstract bibliography lists selected resources for addressing race and ethnicity issues with adolescents who have chronic illnesses and disabilities. References are dated from 1980 to 1991. First, 18 references provide general information about the issues of cultural competence and cultural diversity for health care professionals, educators,…

  14. Identifying Critical Success Factors for TQM and Employee Performance in Malaysian Automotive Industry: A Literature Review

    NASA Astrophysics Data System (ADS)

    Nadia Dedy, Aimie; Zakuan, Norhayati; Zaidi Bahari, Ahamad; Ariff, Mohd Shoki Md; Chin, Thoo Ai; Zameri Mat Saman, Muhamad

    2016-05-01

    TQM is a management philosophy embracing all activities through which the needs and expectations of the customer and the community and the goals of the companies are satisfied in the most efficient and cost effective way by maximizing the potential of all workers in a continuing drive for total quality improvement. TQM is very important to the company especially in automotive industry in order for them to survive in the competitive global market. The main objective of this study is to review a relationship between TQM and employee performance. Authors review updated literature on TQM study with two main targets: (a) evolution of TQM considering as a set of practice, (b) and its impacts to employee performance. Therefore, two research questions are proposed in order to review TQM constructs and employee performance measure: (a) Is the set of critical success factors associated with TQM valid as a whole? (b) What is the critical success factors should be considered to measure employee performance in automotive industry?

  15. Open-system dynamics of entanglement:a key issues review

    NASA Astrophysics Data System (ADS)

    Aolita, Leandro; de Melo, Fernando; Davidovich, Luiz

    2015-04-01

    One of the greatest challenges in the fields of quantum information processing and quantum technologies is the detailed coherent control over each and every constituent of quantum systems with an ever increasing number of particles. Within this endeavor, harnessing of many-body entanglement against the detrimental effects of the environment is a major pressing issue. Besides being an important concept from a fundamental standpoint, entanglement has been recognized as a crucial resource for quantum speed-ups or performance enhancements over classical methods. Understanding and controlling many-body entanglement in open systems may have strong implications in quantum computing, quantum simulations of many-body systems, secure quantum communication or cryptography, quantum metrology, our understanding of the quantum-to-classical transition, and other important questions of quantum foundations. In this paper we present an overview of recent theoretical and experimental efforts to underpin the dynamics of entanglement under the influence of noise. Entanglement is thus taken as a dynamic quantity on its own, and we survey how it evolves due to the unavoidable interaction of the entangled system with its surroundings. We analyze several scenarios, corresponding to different families of states and environments, which render a very rich diversity of dynamical behaviors. In contrast to single-particle quantities, like populations and coherences, which typically vanish only asymptotically in time, entanglement may disappear at a finite time. In addition, important classes of entanglement display an exponential decay with the number of particles when subject to local noise, which poses yet another threat to the already-challenging scaling of quantum technologies. Other classes, however, turn out to be extremely robust against local noise. Theoretical results and recent experiments regarding the difference between local and global decoherence are summarized. Control and

  16. Workplace-Based Assessment: A Review of User Perceptions and Strategies to Address the Identified Shortcomings

    ERIC Educational Resources Information Center

    Massie, Jonathan; Ali, Jason M.

    2016-01-01

    Workplace based assessments (WBAs) are now commonplace in postgraduate medical training. User acceptability and engagement is essential to the success of any medical education innovation. To this end, possessing an insight into trainee and trainer perceptions towards WBAs will help identify the major problems, permitting strategies to be…

  17. Identifying Transition Teacher Competencies through Literature Review and Surveys of Experts and Practitioners

    ERIC Educational Resources Information Center

    Morgan, Robert L.; Callow-Heusser, Catherine A.; Horrocks, Erin L.; Hoffmann, Audrey N.; Kupferman, Scott

    2014-01-01

    We first conducted a synthesis of literature to identify essential transition teacher competencies to guide curriculum development for a personnel preparation program. The synthesis yielded a list of 67 competencies needed by transition teachers. Using the 67 competencies, we next created an electronic survey in which respondents were asked to…

  18. The Use of the Rorschach to Identify Schizophrenia: A Review of the Literature.

    ERIC Educational Resources Information Center

    Entwistle, David Nelson

    Rorschach's use of inkblots as a diagnostic tool has been quite useful in aiding in the diagnosis of schizophrenia. In developing his Comprehensive System for the Rorschach, John Exner (1974) included an index designed to identify schizophrenic subjects. The Schizophrenia Index has evolved to reflect ongoing research. In its current state, the…

  19. A Review and Comparison of Diagnostic Instruments to Identify Students' Misconceptions in Science

    ERIC Educational Resources Information Center

    Gurel, Derya Kaltakci; Eryilmaz, Ali; McDermott, Lillian Christie

    2015-01-01

    Different diagnostic tools have been developed and used by researchers to identify students' conceptions. The present study aimed to provide an overview of the common diagnostic instruments in science to assess students' misconceptions. Also the study provides a brief comparison of these common diagnostic instruments with their strengths and…

  20. PsycINFO search strategies identified methodologically sound therapy studies and review articles for use by clinicians and researchers

    PubMed Central

    Eady, Angela May; Wilczynski, Nancy L.; Haynes, R. Brian

    2008-01-01

    Objective: This study evaluated search strategies for finding high-quality studies on treatment and systematic reviews in PsycINFO. Study design and setting: 64 journals were hand searched at McMaster University. Methodologic criteria were applied to clinically relevant articles to identify “pass” and “fail” articles. 4,985 candidate terms were compiled: 7,463 combinations for therapy articles and 5,246 combinations for reviews. Candidate search strategy results were compared with hand searches. The proposed strategies served as “diagnostic tests” for sound studies; the hand searches were the “gold standard.” Sensitivity, specificity, precision, and accuracy were calculated. Results: 233 (32.5%) of 716 treatment articles met criteria for scientific merit, and 58 (11.5%) of 506 review articles met criteria for systematic reviews. For treatment studies, combined terms had a peak sensitivity of 97.9% (specificity 52.2%). Maximum specificity was 97.7% (sensitivity 51.5%). Sensitivity and specificity were each 79% when optimizing both while minimizing their difference. For review articles, combined terms had a peak sensitivity of 81.0% (specificity 54.4%). Maximum specificity was 98.1% (sensitivity 51.7%). Sensitivity and specificity were each 65% when optimizing both while minimizing their difference. Conclusions: Empirically derived search strategies can achieve high sensitivity and specificity for retrieving sound treatment studies and review articles from PsycINFO. PMID:18083460

  1. Measurement of gait speed in older adults to identify complications associated with frailty: A systematic review.

    PubMed

    Pamoukdjian, Frederic; Paillaud, Elena; Zelek, Laurent; Laurent, Marie; Lévy, Vincent; Landre, Thierry; Sebbane, Georges

    2015-11-01

    Several frailty screening tests in older cancer patients were developed but their statistical performance is low. We aimed to assess whether measurement of usual gait speed (GS) alone could be used as a frailty screening test in older cancer patients. This systematic review was conducted on "pub med" between 1984 and 2014 and included reviews and original studies. Eligibility criteria were: GS over a short distance, alone or included in composite walking tests (Timed Get Up and Go test: TGUG, Short Physical Performance Battery: SPPB) in older people (aged 65 and over) living in a community setting and predictive value of GS on medical complications associated with frailty. 46 articles were finally selected. GS alone is consensual and recommended for screening sarcopenia in elderly. A slow GS is predictive of early death, disability, falls and hospitalization/institutionalization in older people living in a community setting. GS alone is comparable to composite walking tests that do not provide additional information on the medical complications associated with frailty. Despite few studies in geriatric oncology, GS seems to predict overall survival and disability. We suggest GS over 4m (at a threshold of 1m/s) as a new frailty screening test in older cancer patients (65 and over) to guide the implementation of a comprehensive geriatric assessment during the initial management phase or during follow-up. Prospective cohort studies are needed to validate this algorithm and compare it with other screening tool. PMID:26362356

  2. Analytical chemistry of the persistent organic pollutants identified in the Stockholm Convention: A review.

    PubMed

    Xu, Weiguang; Wang, Xian; Cai, Zongwei

    2013-08-01

    Persistent organic pollutants (POPs) are major environmental concern due to their persistence, long-range transportability, bio-accumulation and potentially adverse effects on living organisms. Analytical chemistry plays an essential role in the measurement of POPs and provides important information on their distribution and environmental transformations. Much effort has been devoted during the last two decades to the development of faster, safer, more reliable and more sensitive analytical techniques for these pollutants. Since the Stockholm Convention (SC) on POPs was adopted 12 years ago, analytical methods have been extensively developed. This review article introduces recent analytical techniques and applications for the determination of POPs in environmental and biota samples, and summarizes the extraction, separation and instrumental analyses of the halogenated POPs. Also, this review covers important aspects for the analyses of SC POPs (e.g. lipid determination and quality assurance/quality control (QA/QC)), and finally discusses future trends for improving the POPs analyses and for potential new POPs. PMID:23870403

  3. Personality Development in Two Cultures. A Selective Review on Research Aims and Issues.

    ERIC Educational Resources Information Center

    Thomae, Hans

    1979-01-01

    Summarizes the major forms of cross-cultural research on personality development and discusses their contribution to developmental research. Also discusses some major issues in research on acculturation. (Author/SS)

  4. Issues in the incorporation of economic perspectives and evidence into Cochrane reviews

    PubMed Central

    2013-01-01

    Background Methods for systematic reviews of the effects of health interventions have focused mainly on addressing the question of 'What works?’ or 'Is this intervention effective in achieving one or more specific outcomes?’ Addressing the question 'Is it worth it given the resources available?’ has received less attention. This latter question can be addressed by applying an economic lens to the systematic review process. This paper reflects on the value and desire for the consideration by end users for coverage of an economic perspective in a Cochrane review and outlines two potential approaches and future directions. Methods Two frameworks to guide review authors who are seeking to include an economic perspective are outlined. The first involves conducting a full systematic review of economic evaluations that is integrated into a review of intervention effects. The second involves developing a brief economic commentary. The two approaches share a set of common stages but allow the tailoring of the economic component of the Cochrane review to the skills and resources available to the review team. Results The number of studies using the methods outlined in the paper is limited, and further examples are needed both to explore the value of these approaches and to further develop them. The rate of progress will hinge on the organisational leadership, capacity and resources available to the CCEMG, author teams and other Cochrane entities. Particular methodological challenges to overcome relate to understanding the key economic trade-offs and casual relationships for a given decision problem and informing the development of evaluations designed to support local decision-makers. Conclusions Methods for incorporating economic perspectives and evidence into Cochrane intervention reviews are established. Their role is not to provide a precise estimate of 'cost-effectiveness’ but rather to help end-users of Cochrane reviews to determine the implications of the

  5. Use of stable isotopes to identify sources of methane in Appalachian Basin shallow groundwaters: a review.

    PubMed

    Hakala, J Alexandra

    2014-09-20

    Development of unconventional shale gas reservoirs in the Appalachian Basin has raised questions regarding the potential for these activities to affect shallow groundwater resources. Geochemical indicators, such as stable carbon and hydrogen isotopes of methane, stable carbon isotopes of ethane, and hydrocarbon ratios, have been used to evaluate methane sources however their utility is complicated by influences from multiple physical (e.g., mixing) and geochemical (e.g., redox) processes. Baseline sampling of shallow aquifers prior to development, and measurement of additional geochemical indicators within samples from across the Appalachian Basin, may aid in identifying natural causes for dissolved methane in shallow groundwater versus development-induced pathways. PMID:25033440

  6. Higher Vocational Education in China: A Preliminary Critical Review of Developments and Issues in Liaoning Province

    ERIC Educational Resources Information Center

    Durden, G. R.; Yang, G.

    2006-01-01

    Purpose: This paper addresses the increasingly important economy of China and its associated higher vocational education and training (HVE) system. More specifically, the paper aims to present the findings of a critical review of recent developments in the HVE system in Liaoning province. Design/methodology/approach: As part of this review,…

  7. At Issue: A Comprehensive Review and Synthesis of the Literature on Late Registration

    ERIC Educational Resources Information Center

    Tompkins, Patrick; Williams, Mitchell R.

    2015-01-01

    Using a literature review taxonomy described by Cooper and Hedges (2009), an analysis of 32 publicly available studies of late registrations was conducted to provide researchers and policymakers with an assessment of the extent, quality, and major findings of the studies. The reviewer asserted that few high-quality studies have been conducted on…

  8. Editorial Peer Review for Electronic Journals: Current Issues and Emerging Models.

    ERIC Educational Resources Information Center

    Weller, Anne C.

    2000-01-01

    This article reviews the evolution and growth of electronic journals, and describes the various emerging models of editorial peer review in an electronic environment. Studies to date have focused on attitudes toward electronic journals and citation patterns of electronic journals. Future trends and levels of acceptance of the new models are…

  9. A Review of the Literature on English as a Second Language (ESL) Issues

    ERIC Educational Resources Information Center

    Archibald, John; Bashutski, Kara; Guo, Yan; Jaques, Carly; Johnson, Carla; McPherson, Michelle; Roessingh, Hetty; Shea, Christine

    2008-01-01

    This is a review of the literature that supports content-based language learning. The articles and books reviewed cover recent literature as well as a number of key contributions that date as far back as the late 1980s. There are many commonalities between the earlier works and those of more recent origins since the authors grapple with similar…

  10. Information Processing in Bacteria: Memory, Computation, and Statistical Physics: a Key Issues Review

    PubMed Central

    Lan, Ganhui; Tu, Yuhai

    2016-01-01

    Outline Living systems have to constantly sense their external environment and adjust their internal state in order to survive and reproduce. Biological systems, from as complex as the brain to a single E. coli cell, have to process these information in order to make appropriate decisions. How do biological systems sense the external signals? How do they process the information? How do they respond to the signals? Through years of intense study by biologists, many key molecular players and their interactions have been identified in different biological machineries that carry out these signaling functions. However, an integrated, quantitative understanding of the whole system is still lacking for most cellular signaling pathways, not to say the more complicated neural circuits. To study signaling processes in biology, the key thing to measure is the input-output relationship. The input is the signal itself, such as chemical concentration, external temperature, light (intensity and frequency), and more complex signal such as the face of a cat. The output can be protein conformational changes and covalent modifications (phosphorylation, methylation, etc.), gene expression, cell growth and motility, as well as more complex output such as neuron firing patterns and behaviors of higher animals. Due to the inherent noise in biological systems, the measured input-output dependence is often noisy. These noisy data can be analysed by using powerful tools and concepts from information theory such as mutual information, channel capacity, and maximum entropy hypothesis. This information theory approach has been successfully used to reveal the underlying correlations between key components of the biological networks, to set bounds for the network performance, and to understand possible network architecture in generating the observed correlations. Many such examples appear in recent literature [1, 2, 3, 4, 5, 6]. See [7] for a recent review and references therein. Although

  11. Review of Seismic Hazard Issues Associated with Auburn Dam Project, Sierra Nevada Foothills, California

    USGS Publications Warehouse

    Schwartz, D.P.; Joyner, W.B.; Stein, R.S.; Brown, R.D.; McGarr, A.F.; Hickman, S.H.; Bakun, W.H.

    1996-01-01

    Summary -- The U.S. Geological Survey was requested by the U.S. Department of the Interior to review the design values and the issue of reservoir-induced seismicity for a concrete gravity dam near the site of the previously-proposed Auburn Dam in the western foothills of the Sierra Nevada, central California. The dam is being planned as a flood-control-only dam with the possibility of conversion to a permanent water-storage facility. As a basis for planning studies the U.S. Army Corps of Engineers is using the same design values approved by the Secretary of the Interior in 1979 for the original Auburn Dam. These values were a maximum displacement of 9 inches on a fault intersecting the dam foundation, a maximum earthquake at the site of magnitude 6.5, a peak horizontal acceleration of 0.64 g, and a peak vertical acceleration of 0.39 g. In light of geological and seismological investigations conducted in the western Sierran foothills since 1979 and advances in the understanding of how earthquakes are caused and how faults behave, we have developed the following conclusions and recommendations: Maximum Displacement. Neither the pre-1979 nor the recent observations of faults in the Sierran foothills precisely define the maximum displacement per event on a fault intersecting the dam foundation. Available field data and our current understanding of surface faulting indicate a range of values for the maximum displacement. This may require the consideration of a design value larger than 9 inches. We recommend reevaluation of the design displacement using current seismic hazard methods that incorporate uncertainty into the estimate of this design value. Maximum Earthquake Magnitude. There are no data to indicate that a significant change is necessary in the use of an M 6.5 maximum earthquake to estimate design ground motions at the dam site. However, there is a basis for estimating a range of maximum magnitudes using recent field information and new statistical fault

  12. Assessing the outcomes of participatory research: protocol for identifying, selecting, appraising and synthesizing the literature for realist review

    PubMed Central

    2011-01-01

    Background Participatory Research (PR) entails the co-governance of research by academic researchers and end-users. End-users are those who are affected by issues under study (e.g., community groups or populations affected by illness), or those positioned to act on the knowledge generated by research (e.g., clinicians, community leaders, health managers, patients, and policy makers). Systematic reviews assessing the generalizable benefits of PR must address: the diversity of research topics, methods, and intervention designs that involve a PR approach; varying degrees of end-user involvement in research co-governance, both within and between projects; and the complexity of outcomes arising from long-term partnerships. Methods We addressed the above mentioned challenges by adapting realist review methodology to PR assessment, specifically by developing inductively-driven identification, selection, appraisal, and synthesis procedures. This approach allowed us to address the non-uniformity and complexity of the PR literature. Each stage of the review involved two independent reviewers and followed a reproducible, systematic coding and retention procedure. Retained studies were completed participatory health interventions, demonstrated high levels of participation by non-academic stakeholders (i.e., excluding studies in which end-users were not involved in co-governing throughout the stages of research) and contained detailed descriptions of the participatory process and context. Retained sets are being mapped and analyzed using realist review methods. Results The librarian-guided search string yielded 7,167 citations. A total of 594 citations were retained after the identification process. Eighty-three papers remained after selection. Principle Investigators (PIs) were contacted to solicit all companion papers. Twenty-three sets of papers (23 PR studies), comprising 276 publications, passed appraisal and are being synthesized using realist review methods. Discussion

  13. Modeling energy-sector issues of developing and industrializing countries

    SciTech Connect

    Macal, C.M.; Cirillo, R.R.

    1983-01-01

    This paper identifies important energy-planning issues in industrializing and developing countries based on the Argonne experience in energy-planning studies for Egypt, Korea, Portugal, Argentina, and Jamaica. Modeling approaches are reviewed for applicability to these issues.

  14. Critical narrative review to identify educational strategies promoting physical activity in preschool.

    PubMed

    Kreichauf, S; Wildgruber, A; Krombholz, H; Gibson, E L; Vögele, C; Nixon, C A; Douthwaite, W; Moore, H J; Manios, Y; Summerbell, C D

    2012-03-01

    The aim of this narrative review is critically to evaluate educational strategies promoting physical activity that are used in the preschool setting in the context of obesity prevention programmes. Literature search was conducted between April and August 2010 in English and German databases (PubMED, PsychINFO, PSYNDEX, ERIC, FIS Bildung). Outcomes considered were time and intensity of physical activity, motor skills or measures of body composition. A total of 19 studies were included. Ten studies added physical activity lessons into their curriculum, one study provided more time for free play, eight studies focused on the social and play environment. Studies reporting positive outcomes implemented physical activity sessions that lasted at least 30 min d(-1). Several studies showed that children are most active in the first 10-15 min. The existence or installation of playground markings or fixed play equipment had no effect, whereas the presence or addition of portable play equipment was positively correlated with moderate-to-vigorous physical activity. Teacher training may be a key element for successful interventions. To overcome time constraints, a suggested solution is to integrate physical activity into daily routines and other areas of the preschool curriculum. PMID:22309068

  15. Identifying Organizational Identification as a Basis for Attitudes and Behaviors: A Meta-Analytic Review.

    PubMed

    Lee, Eun-Suk; Park, Tae-Youn; Koo, Bonjin

    2015-09-01

    Organizational identification has been argued to have a unique value in explaining individual attitudes and behaviors in organizations, as it involves the essential definition of entities (i.e., individual and organizational identities). This review seeks meta-analytic evidence of the argument by examining how this identity-relevant construct functions in the nexus of attitudinal/behavioral constructs. The findings show that, first, organizational identification is significantly associated with key attitudes (job involvement, job satisfaction, and affective organizational commitment) and behaviors (in-role performance and extra-role performance) in organizations. Second, in the classic psychological model of attitude-behavior relations (Fishbein & Ajzen, 1975), organizational identification is positioned as a basis from which general sets of those attitudes and behaviors are engendered; organizational identification has a direct effect on general behavior above and beyond the effect of general attitude. Third, the effects of organizational identification are moderated by national culture, a higher-level social context wherein the organization is embedded, such that the effects are stronger in a collectivistic culture than in an individualistic culture. Theoretical and practical implications of the findings and future research directions are discussed. PMID:25984729

  16. Is choline PET useful for identifying intraprostatic tumour lesions? A literature review.

    PubMed

    Chan, Joachim; Syndikus, Isabel; Mahmood, Shelan; Bell, Lynn; Vinjamuri, Sobhan

    2015-09-01

    More than 80% of patients with intermediate-risk or high-risk localized prostate cancer are cured with radiation doses of 74-78 Gy, but high doses increase the risk for late bowel and bladder toxicity among long-term survivors. Dose painting, defined as dose escalation to areas in the prostate containing the tumour, rather than to the whole gland, minimizes dose to normal tissues and hence toxicity. It requires accurate identification of the location and size of these lesions, for which functional MRI is the current gold standard. Many studies have assessed the use of choline PET in staging newly diagnosed patients. This review will discuss important imaging variables affecting the accuracy of choline PET scans, how choline PET contributes to tumour identification and is used in radiotherapy planning and how PET can improve the patient pathway involving prostate radiotherapy. In summary, the available literature shows that the accuracy of choline PET improves with higher tracer doses and delayed imaging (although the optimal uptake time is unclear), and tumour identification by MRI is improved by the addition of PET imaging. We propose future research with prolonged choline uptake time and multiphase imaging, which may further improve accuracy. PMID:25955523

  17. A comprehensive review of the Kumbh Mela: identifying risks for spread of infectious diseases.

    PubMed

    Sridhar, S; Gautret, P; Brouqui, P

    2015-02-01

    The Kumbh Mela in India is the largest mass gathering in the world which witnessed close to 100 million visitors in 2013. An event of this magnitude presents challenges. Increased population density, reduced hygienic conditions and exposure to environmental pollutants pave the way for easy transmission of pathogens. Due to the possibility of epidemics, the primary focus should be on identifying the potential risk factors and implementing appropriate preventive measures. The context of religion and psychology of the pilgrims is also closely associated with the evolution of the risk factors and so forms an important part of the discussion. We provide a brief background to the Kumbh Mela with a description of the existing and potential risk factors that require our attention. PMID:25682278

  18. A Review of Some Print Instructional Materials on Women and Women's Issues

    ERIC Educational Resources Information Center

    Fentress, Myrtle A.

    1975-01-01

    This essay review of materials on women and women's studies includes reference books, biographies, autobiographies, anthologies, pamphlets and booklets, social studies programs, simulations and games, and radio shows. (JR)

  19. Standards for the Global Information Infrastructure (GII): A Review of Recent Developments, Ongoing Efforts, Future Directions and Issues.

    ERIC Educational Resources Information Center

    Needleman, Mark H.

    1996-01-01

    Reviews developments related to standards in electronic and networked information. Discusses traditional library and Internet communities, and notes the importance of having a supporting infrastructure in place. Topics include: Z39.50; Z39.56 Serial Item/Contribution Identifier (SICI); Interlibrary Loan (ILL) Protocol; character set standards;…

  20. Major Elements and Issues in Performance Management System: A Literature Review

    ERIC Educational Resources Information Center

    Bae, Eul-Kyoo

    2006-01-01

    Due to rapidly changing business environment, HRD practitioners are unprecedentedly demanded to actively participate in improving organizational effectiveness as performance management specialist. The purpose of this study was to examine and discuss major elements and issues in performance management system through an extensive literature review…

  1. Psychological Testing and Psychological Assessment: A Review of Evidence and Issues.

    ERIC Educational Resources Information Center

    Meyer, Gregory J.; Finn, Stephen E.; Eyde, Lorraine D.; Kay, Gary G.; Moreland, Kevin L.; Dies, Robert R.; Eisman, Elena J.; Kubiszyn, Tom W.; Reed, Geoffrey M.

    2001-01-01

    Summarizes issues associated with psychological assessment, concluding that: psychological test validity is strong and is comparable to medical test validity; distinct assessment methods provide unique sources of information; and clinicians who rely solely on interviews are prone to incomplete understandings. Suggests that multimethod assessment…

  2. Language Issues in Literacy and Bilingual/Multicultural Education. Harvard Educational Review Reprint. Series No. 22.

    ERIC Educational Resources Information Center

    Minami, Masahiko, Ed.; Kennedy, Bruce P., Ed.

    This collection of articles related to language issues and literacy and bilingual and multicultural education include the following: "Three Processes in the Child's Acquisition of Syntax" (Roger Brown and Ursula Bellugi); "Pre-School Children's Knowledge of English Phonology" (Charles Read); "Stages in Language Development and Reading Exposure"…

  3. What Do People Know about Key Environmental Issues? A Review of Environmental Knowledge Surveys

    ERIC Educational Resources Information Center

    Robelia, Beth; Murphy, Tony

    2012-01-01

    This paper presents results from 15 little publicized state and national environmental surveys in the US that used similar questions. Our analysis reveals trends in adult understanding of environmental issues. These trends indicate that many may have difficulty making informed decisions about environmental policy as citizens, voters, and…

  4. TPV energy conversion: A review of material and cell related issues

    SciTech Connect

    Bhat, I.B.; Borrego, J.M.; Gutmann, R.J.; Ostrogorsky, A.G.

    1996-08-01

    This paper presents an overview of thermophotovoltaic (TPV) energy conversion using low band gap semiconductor photovoltaic cells. Physics of PN junctions related to TPV cells is described and the factors that affect overall cell efficiencies are outlined. Current status of bulk and epitaxial growth of TPV materials and cell fabrication issues are also described.

  5. Sports and Athletics: Issues for Adolescents with Chronic Illnesses and Disabilities. CYDLINE Reviews.

    ERIC Educational Resources Information Center

    Minnesota Univ., Minneapolis. National Center for Youth with Disabilities.

    This annotated bibliography focuses on issues in sports and athletics for adolescents and young adults with chronic illnesses and disabilities. The listings are drawn from the National Resource Library of the National Center for Youth with Disabilities, which includes journals, books, and non-published materials. The section on bibliographic…

  6. Trends and Issues in Educational Technologies: A Review of Recent Research in TOJET

    ERIC Educational Resources Information Center

    Alper, Ayfer; Gulbahar, Yasemin

    2009-01-01

    The aim of this research study is to investigate the articles published between 2003-2007 in "Turkish Online Journal of Educational Technology" ("TOJET") in order to reveal the trends and issues addressed in this electronic journal for the field of educational technology. The specific purposes of this article are to reveal: (1) the methodologies…

  7. Legal Issues for Adolescents with Chronic Illnesses and Disabilities and Their Families. CYDLINE Reviews.

    ERIC Educational Resources Information Center

    Minnesota Univ., Minneapolis. National Center for Youth with Disabilities.

    This collection of annotated bibliographies focuses on a broad spectrum of legal issues, and is drawn from a national database of current programs and literature regarding adolescents with chronic illnesses and other disabilities. Bibliographic materials listed include documents and articles concerning the following: consent and confidentiality…

  8. Self-Esteem: Issues for Adolescents with Chronic Illnesses and Disabilities. CYDLINE Reviews.

    ERIC Educational Resources Information Center

    Minnesota Univ., Minneapolis. National Center for Youth with Disabilities.

    This annotated bibliography focuses on issues of self-esteem in adolescents with disabilities, which is seen as closely related to development of critical social skills. References have been drawn from the National Center for Youth with Disabilities' National Resource Library, a database about youth with chronic illnesses and disabilities. The…

  9. Recreation and Leisure: Issues for Adolescents with Chronic Illnesses and Disabilities. CYDLINE Reviews.

    ERIC Educational Resources Information Center

    Minnesota Univ., Minneapolis. National Center for Youth with Disabilities.

    This bibliography presents 162 annotated references (including bibliographic materials, training and educational materials, and programs) about issues of recreation and leisure for adolescents and young adults with chronic illnesses and disabilities. Each reference usually contains a full bibliographic citation, a brief descriptive abstract, and…

  10. Identifying Factors Influencing Pancreatic Cancer Management to Inform Quality Improvement Efforts and Future Research: A Scoping Systematic Review.

    PubMed

    Gagliardi, Anna R; Soong, Daniel; Gallinger, Steven

    2016-02-01

    Pancreatic cancer (PC) patients appear to receive suboptimal care. We conducted a systematic review to identify factors that influence PC management which are amenable to quality improvement. MEDLINE, EMBASE, and the references of eligible studies were searched from 1996 to July 2014. Two authors independently selected and reviewed eligible studies. Identified factors were mapped onto a framework of determinants of care delivery and outcomes. Methodological quality of studies was assessed using Downs and Black criteria. Most of the 33 eligible studies were population-based observational studies conducted in the United States. Patient (age, socioeconomic status, race) and institutional (case volume, academic status) factors influence care delivery and outcomes (complications, mortality, readmission, survival). Two studies implemented interventions to improve quality of care (centralization to high-volume hospitals, multidisciplinary care). One study examined system determinants (referral wait times). No studies examined the influence of guideline or provider characteristics. The overall lack of health services research in PC is striking. Factors and interventions identified here can be used to plan PC quality improvement programs. Further research is needed to explore the influence of guideline and provider factors on PC management and evaluate the impact of quality improvement interventions. PMID:26752254

  11. Information processing in bacteria: memory, computation, and statistical physics: a key issues review

    NASA Astrophysics Data System (ADS)

    Lan, Ganhui; Tu, Yuhai

    2016-05-01

    Living systems have to constantly sense their external environment and adjust their internal state in order to survive and reproduce. Biological systems, from as complex as the brain to a single E. coli cell, have to process these data in order to make appropriate decisions. How do biological systems sense external signals? How do they process the information? How do they respond to signals? Through years of intense study by biologists, many key molecular players and their interactions have been identified in different biological machineries that carry out these signaling functions. However, an integrated, quantitative understanding of the whole system is still lacking for most cellular signaling pathways, not to say the more complicated neural circuits. To study signaling processes in biology, the key thing to measure is the input-output relationship. The input is the signal itself, such as chemical concentration, external temperature, light (intensity and frequency), and more complex signals such as the face of a cat. The output can be protein conformational changes and covalent modifications (phosphorylation, methylation, etc), gene expression, cell growth and motility, as well as more complex output such as neuron firing patterns and behaviors of higher animals. Due to the inherent noise in biological systems, the measured input-output dependence is often noisy. These noisy data can be analysed by using powerful tools and concepts from information theory such as mutual information, channel capacity, and the maximum entropy hypothesis. This information theory approach has been successfully used to reveal the underlying correlations between key components of biological networks, to set bounds for network performance, and to understand possible network architecture in generating observed correlations. Although the information theory approach provides a general tool in analysing noisy biological data and may be used to suggest possible network architectures in

  12. Information processing in bacteria: memory, computation, and statistical physics: a key issues review.

    PubMed

    Lan, Ganhui; Tu, Yuhai

    2016-05-01

    Living systems have to constantly sense their external environment and adjust their internal state in order to survive and reproduce. Biological systems, from as complex as the brain to a single E. coli cell, have to process these data in order to make appropriate decisions. How do biological systems sense external signals? How do they process the information? How do they respond to signals? Through years of intense study by biologists, many key molecular players and their interactions have been identified in different biological machineries that carry out these signaling functions. However, an integrated, quantitative understanding of the whole system is still lacking for most cellular signaling pathways, not to say the more complicated neural circuits. To study signaling processes in biology, the key thing to measure is the input-output relationship. The input is the signal itself, such as chemical concentration, external temperature, light (intensity and frequency), and more complex signals such as the face of a cat. The output can be protein conformational changes and covalent modifications (phosphorylation, methylation, etc), gene expression, cell growth and motility, as well as more complex output such as neuron firing patterns and behaviors of higher animals. Due to the inherent noise in biological systems, the measured input-output dependence is often noisy. These noisy data can be analysed by using powerful tools and concepts from information theory such as mutual information, channel capacity, and the maximum entropy hypothesis. This information theory approach has been successfully used to reveal the underlying correlations between key components of biological networks, to set bounds for network performance, and to understand possible network architecture in generating observed correlations. Although the information theory approach provides a general tool in analysing noisy biological data and may be used to suggest possible network architectures in

  13. Information processing in bacteria: memory, computation, and statistical physics: a key issues review

    NASA Astrophysics Data System (ADS)

    Lan, Ganhui; Tu, Yuhai

    2016-05-01

    Living systems have to constantly sense their external environment and adjust their internal state in order to survive and reproduce. Biological systems, from as complex as the brain to a single E. coli cell, have to process these data in order to make appropriate decisions. How do biological systems sense external signals? How do they process the information? How do they respond to signals? Through years of intense study by biologists, many key molecular players and their interactions have been identified in different biological machineries that carry out these signaling functions. However, an integrated, quantitative understanding of the whole system is still lacking for most cellular signaling pathways, not to say the more complicated neural circuits. To study signaling processes in biology, the key thing to measure is the input-output relationship. The input is the signal itself, such as chemical concentration, external temperature, light (intensity and frequency), and more complex signals such as the face of a cat. The output can be protein conformational changes and covalent modifications (phosphorylation, methylation, etc), gene expression, cell growth and motility, as well as more complex output such as neuron firing patterns and behaviors of higher animals. Due to the inherent noise in biological systems, the measured input-output dependence is often noisy. These noisy data can be analysed by using powerful tools and concepts from information theory such as mutual information, channel capacity, and the maximum entropy hypothesis. This information theory approach has been successfully used to reveal the underlying correlations between key components of biological networks, to set bounds for network performance, and to understand possible network architecture in generating observed correlations. Although the information theory approach provides a general tool in analysing noisy biological data and may be used to suggest possible network architectures in

  14. Validity and utility of ICD-10 administrative health data for identifying ST- and non-ST-elevation myocardial infarction based on physician chart review

    PubMed Central

    Patel, Alka B.; Quan, Hude; Welsh, Robert C.; Deckert-Sookram, Jessica; Tymchak, Wayne; Sookram, Sunil; Surdhar, Ian; Kaul, Padma

    2015-01-01

    Background: Health care administrative databases are useful for assessing the population-level burden of disease and examining issues related to access, costs and quality of care. In these databases, the diagnoses and procedures are coded with the use of the World Health Organization International Classification of Diseases (ICD). We examined the validity of 2 ICD-10 coding definitions for categorizing patients with acute myocardial infarction (MI) as having ST-elevation MI (STEMI) or non-ST-elevation MI (non-STEMI). Methods: Charts of patients with acute MI discharged between April and June 2007 from 3 hospitals in Edmonton, were reviewed to define the acute MI subtype (i.e., STEMI v. non-STEMI). The agreement between clinician chart review and STEMI/non-STEMI classification based on the standard (ICD-10 I21.x) and the supplementary electrocardiogram (ECG) codes (R94.3x) was determined. We assessed the effect of these alternative definitions on in-hospital mortality estimates by applying them to the data for all patients with acute MI admitted to hospital in the province from April 2007 to March 2010. Results: Of the 297 patients, 49.2% were identified as having STEMI based on chart review, 44.4% using the standard definition, and 44.1% using the ECG definition. Both the standard and ECG definitions provided high agreement (92% for STEMI and 100% for non-STEMI) with the chart review classification. In the larger population-level cohort (n = 15 148), use of the standard definition or the ECG definition did not affect in-hospital mortality estimates for patients with STEMI and those with non-STEMI. Interpretation: The standard definition appears equivalent to the definition using supplementary ECG codes to subcategorize patients with acute MI as having STEMI or non-STEMI. These findings may be relevant for the development of later versions of ICD codes.

  15. Nuclear Regulatory Commission activities to prepare for reviewing license applications and issuing licenses

    SciTech Connect

    Uleck, R.B.; DeFino, C.V.

    1991-12-31

    The Low-Level Radioactive Waste Policy Amendments Act of 1985 (LLRWPAA) assigned States the responsibility to provide for disposal of commercial low-level radioactive waste (LLRW) by 1993. The LLRWPAA also required the US Nuclear Regulatory Commission (NRC) to establish procedures and develop the technical review capability to process license applications for new LLRW disposal facilities. Under the LLRWPAA, NRC is required, to the extent practicable, to complete its review of an LLRW disposal facility license application within 15 months of its submittal by a State. This provision of the LLRWPAA helps ensure that NRC, in addition to protecting public health and safety and the environment, facilitates States` achievement of LLRWPAA milestones for new facility development. A timely NRC review is needed for States to accomplish their objective of having new disposal facilities in operation on the dates prescribed in the LLRWPAA. To help assure NRC and States` compliance with the provisions of the LLRWPAA, NRC has developed a licensing review strategy that includes: (1) the further development of regulatory guidance, (2) enhancement of licensing review capability, and (3) prelicensing regulatory consultation with potential applicants.

  16. Fetal growth: a review of terms, concepts and issues relevant to obstetrics.

    PubMed

    Mayer, C; Joseph, K S

    2013-02-01

    The perinatal literature includes several potentially confusing and controversial terms and concepts related to fetal size and growth. This article discusses fetal growth from an obstetric perspective and addresses various issues including the physiologic mechanisms that determine fetal growth trajectories, known risk factors for abnormal fetal growth, diagnostic and prognostic issues related to restricted and excessive growth and temporal trends in fetal growth. Also addressed are distinctions between fetal growth 'standards' and fetal growth 'references', and between fetal growth charts based on estimated fetal weight vs those based on birth weight. Other concepts discussed include the incidence of fetal growth restriction in pregnancy (does the frequency of fetal growth restriction increase or decrease with increasing gestation?), the obstetric implications of studies showing associations between fetal growth and adult chronic illnesses (such as coronary heart disease) and the need for customizing fetal growth standards. PMID:22648955

  17. E-waste: a problem or an opportunity? Review of issues, challenges and solutions in Asian countries.

    PubMed

    Herat, Sunil; Agamuthu, P

    2012-11-01

    Safe management of electronic and electrical waste (e-waste/WEEE) is becoming a major problem for many countries around the world. In particular, developing countries face a number of issues with the generation, transboundary movement and management of e-waste. It is estimated that the world generates around 20-50 million tonnes of e-waste annually, most of it from Asian countries. Improper handling of e-waste can cause harm to the environment and human health because of its toxic components. Several countries around the world are now struggling to deal with this emerging threat. Although the current emphasis is on end-of-life management of e-waste activities, such as reuse, servicing, remanufacturing, recycling and disposal, upstream reduction of e-waste generation through green design and cleaner production is gaining much attention. Environmentally sound management (ESM) of e-waste in developing countries is absent or very limited. Transboundary movement of e-waste is a major issue throughout the region. Dealing with the informal recycling sector is a complex social and environmental issue. There are significant numbers of such challenges faced by these countries in achieving ESM of e-waste. This article aims to present a review of challenges and issues faced by Asian countries in managing their e-waste in a sustainable way. PMID:22851536

  18. How to Identify Students for School-based Depression Intervention: Can School Record Review Be Substituted for Universal Depression Screening?

    PubMed Central

    Kuo, Elena S.; Stoep, Ann Vander; Herting, Jerald R.; Grupp, Katherine; McCauley, Elizabeth

    2013-01-01

    Problem Early identification and intervention is critical for reducing the adverse effects of depression on academic and occupational performance. Cost-effective approaches are needed for identifying adolescents at high depression risk. This study evaluated the utility of school record review versus universal school-based depression screening for determining eligibility for an indicated depression intervention program implemented in the middle school setting. Methods Algorithms derived from grades, attendance, suspensions, and basic demographic information were evaluated with regard to their ability to predict students’ depression screening scores. Findings The school information-based algorithms proved poor proxies for individual students’ depression screening results. However, school records showed promise for identifying low, medium, and high yield subgroups on the basis of which efficient screening targeting decisions could be made. Conclusions Study results will help to guide school nurses who coordinate indicated depression intervention programs in school settings as they evaluate options of approaches for determining which students are eligible for participation. PMID:23351107

  19. A Literature Review of Gender Issues in Supervision: Power Differentials and Dual Relationship.

    ERIC Educational Resources Information Center

    Downs, Louis

    This review of recent literature suggests that there exist gender-based problems in counselor training supervision. Several of these problems are discussed in this paper. Though opinions of counselors appear, for the most part, to support stereotypes, actual measurements of supervisor behaviors suggest that stereotypical definitions may not always…

  20. Cancer and Intellectual Disability: A Review of Some Key Contextual Issues

    ERIC Educational Resources Information Center

    Hogg, James; Tuffrey-Wijne, Irene

    2008-01-01

    Research into the health of people with intellectual disabilities has increasingly focused on the occurrence of cancer in this population. Information on the incidence and prevalence of cancer is reviewed in both institutional and community settings. Examples of environmental causation are considered including "Helicobacter pylori."…

  1. Books against Television? Making an Issue of Television in Early Childhood Education. Book Review.

    ERIC Educational Resources Information Center

    Weber, Sandra; Brody, Marie-Helene

    2002-01-01

    Presents a critical, comparative review of three popular books about children and television. Raises questions and concerns about the multiple roles that television can assume in children's lives and the roles that adults can play in mediating children's experiences. Focuses on three key themes/concerns: changing functions of television, the…

  2. Practitioner Review: Adolescent Alcohol Use Disorders--Assessment and Treatment Issues

    ERIC Educational Resources Information Center

    Perepletchikova, Francheska; Krystal, John H.; Kaufman, Joan

    2008-01-01

    Background: Alcohol use disorders in adolescents are associated with significant morbidity and mortality. Over the past decade, there has been a burgeoning of research on adolescent alcohol use disorders. Methods: A summary of the alcohol assessment tools is provided, and randomized studies reviewed and synthesized to provide an overview of state…

  3. Appraising the Economic And Social Effects of Advertising. A Review of Issues and Evidence.

    ERIC Educational Resources Information Center

    Pearce, Michael; And Others

    Three major aspects of advertising/marketing communications are reviewed comprehensively in this report. Consumer behavior with its associated attitudes and purchasing behavior are discussed in regard to the choices of specific brands within major product categories. The relationship between advertising and the structure of markets is considered…

  4. Special Education Law: A Review and Analysis. FOCUS on Legal Issues for School Administrators, 1999.

    ERIC Educational Resources Information Center

    Dayton, John; Arnau, Lea M.

    This review explains special education law in a manner comprehensible for educators who may be unfamiliar with the many statutes, regulations, and cases in this area of law. It provides a brief history of special education law with an emphasis on court cases and legislation that established the rights of children with disabilities. It examines the…

  5. Issues in Early Core French: A Selective and Preliminary Review of the Literature, 1975-1981.

    ERIC Educational Resources Information Center

    Stern, H. H.

    This literature review looked at core French (programs of French as a second language taught as a subject) as opposed to immersion French in terms of starting grade, instructional time, instructional materials, children could bring bilingual experience to learning French, starting age is less important than sometimes argued. Neither starting age…

  6. College Alcohol Abuse: A Review of the Problems, Issues, and Prevention Approaches.

    ERIC Educational Resources Information Center

    Vicary, Judith R.; Karshin, Christine M.

    2002-01-01

    Reviews the extent of underage drinking and alcohol abuse by college students currently and in an historical perspective. Profiles of those individuals and groups most at risk for problem drinking are suggested. Provides examples of efforts to prevent or reduce collegiate drinking, including campus-community coalitions, environmental management…

  7. Issues in Business and Medical Education: Brief Literature Review on Strategic Management of Health Care Institutions.

    ERIC Educational Resources Information Center

    Smith, Alan D.

    The literature on the use of strategic management principles by health care organizations is reviewed. After considering basic concepts of strategic management and managerial problems in nonprofit organizations, strategic planning and management of health care organizations are covered. Attention is directed to the health care environment,…

  8. Bioavailability as an issue in risk assessment and management of food cadmium: A review

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The bioavailability of cadmium (Cd) from food could be an important determinant of the risk potential of dietary Cd to the consumer. This review summarizes recent work that describes the effects of marginal deficiencies of the essential nutrients zinc (Zn), iron (Fe), and calcium (Ca) on the enhance...

  9. A Review of Exercise as Intervention for Sedentary Hazardous Drinking College Students: Rationale and Issues

    ERIC Educational Resources Information Center

    Weinstock, Jeremiah

    2010-01-01

    College students have high rates of alcohol problems despite a number of intervention initiatives designed to reduce alcohol use. Substance use, including heavy drinking, often occurs at the expense of other, substance-free, activities. This review examines the promotion of one specific substance-free activity--exercise--as an intervention for…

  10. Direct Behavior Rating: A Review of the Issues and Research in Its Development

    ERIC Educational Resources Information Center

    Chafouleas, Sandra M.

    2011-01-01

    The conceptual foundation for Direct Behavior Rating as a behavior assessment method is reviewed. A contemporary definition of Direct Behavior Rating is framed as combining strengths of systematic direct observation and behavior rating scales, which may result in a usable and defensible assessment tool for educators engaged in formative purposes.…

  11. SUMMARY REVIEW OF THE HEALTH EFFECTS ASSOCIATED WITH COPPER: HEALTH ISSUE ASSESSMENT

    EPA Science Inventory

    The Health Assessment Summary Document is a brief review of the scientific knowledge on copper. The emphasis of the document is on inhalation exposure from atmospheric copper and the environmental, ecological and health effects from the species of copper expected to be present in...

  12. ISSUES AND PROBLEMS IN CONTEMPORARY EDUCATIONAL ADMINISTRATION, A REVIEW OF RELATED LITERATURE. SUPPLEMENTARY REPORT.

    ERIC Educational Resources Information Center

    GOLDHAMMER, KEITH; AND OTHERS

    SOME 138 ARTICLES, RESEARCH REPORTS, AND UNPUBLISHED ITEMS, DATING FROM 1953 TO 1966, CONTRIBUTED TO THE DEVELOPMENT OF A RATIONALE FOR A MAJOR STUDY OF PROBLEMS FACING PUBLIC SCHOOL SUPERINTENDENTS. BRIEF REVIEWS COORDINATE THE MATERIAL UNDER SIX MAIN HEADINGS--(1) EDUCATIONAL CHANGE, (2) NEGOTIATIONS AND TEACHER MILITANCY, (3) ASPECTS OF…

  13. A Multistate Review of Professional Teaching Standards. Summary. Issues & Answers. REL 2009-No. 075

    ERIC Educational Resources Information Center

    White, Melissa Eiler; Makkonen, Reino; Stewart, Kari Becker

    2009-01-01

    This document presents a summary of a larger report that reviews teaching standards in six states (California, Florida, Illinois, North Carolina, Ohio, and Texas) focuses on the structure, target audience, and selected content of the standards to inform California's revision of its teaching standards. The report was developed at the request of key…

  14. The Issue of Binding Arbitration in the Public Schools. Public Review of Educational Policy (PREP).

    ERIC Educational Resources Information Center

    Pennsylvania School Boards Association, Inc., Harrisburg.

    Intended primarily for educators, legislators, and the general public in the state of Pennsylvania, this public affairs brochure addresses the question of whether binding arbitration should be legislated in that state as a means of resolving labor disputes between a local school district and its employees. The brochure reviews the history of…

  15. Psychological issues relevant to astronaut selection for long-duration space flight: a review of the literature.

    PubMed

    Collins, Daniel L

    2003-01-01

    This technical paper reviews the current literature on psychological issues relevant to astronaut selection for long-duration space flights. Interpersonal problems have been and remain a recurring problem for both short and long-duration space flights. Even after completion of the space mission, intense psychological aftereffects are reported. The specific behavioral problems experienced during United States and Soviet Union space flights are reviewed, specifically addressing contentious episodes and impaired judgments that occurred during the Mercury, Apollo, and Skylab missions. Psychological tests used in the selection process for the space program have focused primarily on the detection of gross psychopathologies in potential candidates. Although these psychological instruments excluded some people from becoming astronauts, the battery of tests failed to predict which individuals would manifest behavioral aberrations in judgment, cooperative functioning, overt irritability, or destructive interpersonal actions. PMID:14552348

  16. A review on technologies and their usage in solid waste monitoring and management systems: Issues and challenges.

    PubMed

    Hannan, M A; Abdulla Al Mamun, Md; Hussain, Aini; Basri, Hassan; Begum, R A

    2015-09-01

    In the backdrop of prompt advancement, information and communication technology (ICT) has become an inevitable part to plan and design of modern solid waste management (SWM) systems. This study presents a critical review of the existing ICTs and their usage in SWM systems to unfold the issues and challenges towards using integrated technologies based system. To plan, monitor, collect and manage solid waste, the ICTs are divided into four categories such as spatial technologies, identification technologies, data acquisition technologies and data communication technologies. The ICT based SWM systems classified in this paper are based on the first three technologies while the forth one is employed by almost every systems. This review may guide the reader about the basics of available ICTs and their application in SWM to facilitate the search for planning and design of a sustainable new system. PMID:26072186

  17. Non-equilibrium physics and evolution—adaptation, extinction, and ecology: a Key Issues review

    NASA Astrophysics Data System (ADS)

    Kussell, E.; Vucelja, M.

    2014-10-01

    Evolutionary dynamics in nature constitute an immensely complex non-equilibrium process. We review the application of physical models of evolution, by focusing on adaptation, extinction, and ecology. In each case, we examine key concepts by working through examples. Adaptation is discussed in the context of bacterial evolution, with a view toward the relationship between growth rates, mutation rates, selection strength, and environmental changes. Extinction dynamics for an isolated population are reviewed, with emphasis on the relation between timescales of extinction, population size, and temporally correlated noise. Ecological models are discussed by focusing on the effect of spatial interspecies interactions on diversity. Connections between physical processes—such as diffusion, turbulence, and localization—and evolutionary phenomena are highlighted.

  18. Non-equilibrium physics and evolution--adaptation, extinction, and ecology: a key issues review.

    PubMed

    Kussell, E; Vucelja, M

    2014-10-01

    Evolutionary dynamics in nature constitute an immensely complex non-equilibrium process. We review the application of physical models of evolution, by focusing on adaptation, extinction, and ecology. In each case, we examine key concepts by working through examples. Adaptation is discussed in the context of bacterial evolution, with a view toward the relationship between growth rates, mutation rates, selection strength, and environmental changes. Extinction dynamics for an isolated population are reviewed, with emphasis on the relation between timescales of extinction, population size, and temporally correlated noise. Ecological models are discussed by focusing on the effect of spatial interspecies interactions on diversity. Connections between physical processes--such as diffusion, turbulence, and localization--and evolutionary phenomena are highlighted. PMID:25303141

  19. Establishing Minimum Flow Requirements Based on Benthic Vegetation: What are Some Issues Related to Identifying Quantity of Inflow and Tools Used to Quantify Ecosystem Response?

    NASA Astrophysics Data System (ADS)

    Hunt, M. J.; Nuttle, W. K.; Cosby, B. J.; Marshall, F. E.

    2005-05-01

    Establishing minimum flow requirements in aquatic ecosystems is one way to stipulate controls on water withdrawals in a watershed. The basis of the determination is to identify the amount of flow needed to sustain a threshold ecological function. To develop minimum flow criteria an understanding of ecological response in relation to flow is essential. Several steps are needed including: (1) identification of important resources and ecological functions, (2) compilation of available information, (3) determination of historical conditions, (4) establishment of technical relationships between inflow and resources, and (5) identification of numeric criteria that reflect the threshold at which resources are harmed. The process is interdisciplinary requiring the integration of hydrologic and ecologic principles with quantitative assessments. The tools used quantify the ecological response and key questions related to how the quantity of flow influences the ecosystem are examined by comparing minimum flow determination in two different aquatic systems in South Florida. Each system is characterized by substantial hydrologic alteration. The first, the Caloosahatchee River is a riverine system, located on the southwest coast of Florida. The second, the Everglades- Florida Bay ecotone, is a wetland mangrove ecosystem, located on the southern tip of the Florida peninsula. In both cases freshwater submerged aquatic vegetation (Vallisneria americana or Ruppia maritima), located in areas of the saltwater- freshwater interface has been identified as a basis for minimum flow criteria. The integration of field studies, laboratory studies, and literature review was required. From this information we developed ecological modeling tools to quantify and predict plant growth in response to varying environmental variables. Coupled with hydrologic modeling tools questions relating to the quantity and timing of flow and ecological consequences in relation to normal variability are addressed.

  20. Significant Issues Confronting Vocational Education: Implications for UCVE Institutions.

    ERIC Educational Resources Information Center

    Khaleel, Ibrahim Adamu

    A study identified significant issues currently confronting vocational education and described what role(s) the University Council for Vocational Education (UCVE) might pursue relative to each issue. To identify significant issues, a literature review, analysis, and consensus building were used. A Delphi method was used to build consensus on the…

  1. How molecular motors extract order from chaos (a key issues review)

    NASA Astrophysics Data System (ADS)

    Hoffmann, Peter M.

    2016-03-01

    Molecular motors are the workhorses of living cells. Seemingly by ‘magic’, these molecules are able to complete purposeful tasks while being immersed in a sea of thermal chaos. Here, we review the current understanding of how these machines work, present simple models based on thermal ratchets, discuss implications for statistical physics, and provide an overview of ongoing research in this important and fascinating field of study.

  2. How molecular motors extract order from chaos (a key issues review).

    PubMed

    Hoffmann, Peter M

    2016-03-01

    Molecular motors are the workhorses of living cells. Seemingly by 'magic', these molecules are able to complete purposeful tasks while being immersed in a sea of thermal chaos. Here, we review the current understanding of how these machines work, present simple models based on thermal ratchets, discuss implications for statistical physics, and provide an overview of ongoing research in this important and fascinating field of study. PMID:26863000

  3. The Mode Effect: A Literature Review of Human and Technological Issues in Computerized Testing

    ERIC Educational Resources Information Center

    Leeson, Heidi V.

    2006-01-01

    In addition to the potential that computer-based testing (CBT) offers, empirical evidence has found that identical computerized and paper-and-pencil tests have not produced equivalent test-taker performance. Referred to as the "mode effect," previous literature has identified many factors that may be responsible for such differential performance.…

  4. Service Delivery to Young Handicapped Children in Rural Areas: A Review of Issues and Practices.

    ERIC Educational Resources Information Center

    Nash, Tina Eaton; And Others

    The paper examines barriers faced by educators and administrators in serving young handicapped children in rural areas and suggests approaches to overcoming these barriers. Among problems identified are transportation; funding shortages due to a lower tax base and higher levels of poverty; unemployment, and seasonal employment; staff shortages;…

  5. Review of the Australian Apprenticeship and Traineeship Literature: References and Their Key Issues. Australian Apprenticeships.

    ERIC Educational Resources Information Center

    Saunders, S.

    This volume is a survey of more than 125 Australian apprenticeship and traineeship references from 1985-99. Each item identifies author/editor/organization, date, title, organization and place of publication or development. A "key" provides a descriptive phrase relating to the reference type, such as an industry-body paper on training delivery (to…

  6. Psychometric Issues in Organizational Stressor Research: A Review and Implications for Sport Psychology

    ERIC Educational Resources Information Center

    Arnold, Rachel; Fletcher, David

    2012-01-01

    Organizational stressors can potentially elicit a number of undesirable consequences for sport performers. It is, therefore, imperative that psychologists better understand the demands that athletes encounter via their exploration and assessment. However, although researchers have identified a wide range of organizational stressors in competitive…

  7. Anticoagulation Management and Monitoring during Pediatric Extracorporeal Life Support: A Review of Current Issues

    PubMed Central

    Ryerson, Lindsay M.; Lequier, Laurence L.

    2016-01-01

    Anticoagulation is an imperfect science and is even more complicated in neonates and young children. The addition of the extracorporeal life support (ECLS) foreign circuit adds an additional layer of complexity. Anticoagulation goals during ECLS are to maintain a clot-free circuit and a hemostatically balanced patient. Unfractionated heparin (UFH) is the default gold standard anticoagulant as no large studies have been performed on any other anticoagulants. This review will focus on the advantages and disadvantages of the various methods to monitor UFH anticoagulation, discuss alternative anticoagulants, and examine bleeding and thrombotic complications during ECLS.

  8. Polymer Matrix Composites: A Perspective for a Special Issue of Polymer Reviews

    SciTech Connect

    Kessler, Michael R.

    2012-09-04

    Polymer matrix composites, with their high specific strength and stiffness, are used in a wide range of applications from large wind turbine blades to microelectronics. This perspective article provides a brief primer on polymer matrix composites, discusses some of their advantages and limitations, and describes a number of emerging trends in the field. In addition, it introduces four review articles on the topics of recent developments in carbon fibers, natural fiber reinforced composites, evaluation of the interface between the fiber reinforcement and polymer matrix, and carbon nanotube reinforced polymers.

  9. Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia

    PubMed Central

    Matsumoto, Rae R.; Seminerio, Michael J.; Turner, Ryan C.; Robson, Matthew J.; Nguyen, Linda; Miller, Diane B.; O’Callaghan, James P.

    2015-01-01

    Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine. PMID:24836729

  10. Simulating reduced gravity: a review of biomechanical issues pertaining to human locomotion.

    PubMed

    Davis, B L; Cavanagh, P R

    1993-06-01

    In the decade preceding Apollo missions to the Moon, extensive studies were conducted on human locomotion in reduced gravity. These investigations focused primarily on issues of maneuverability and energy expenditure and not on musculoskeletal loading, which is of more interest to planners of long-duration space missions. The techniques have included water immersion, parabolic aircraft flights, supine and erect cable suspension and centrifugal methods. The practical implications of the findings from these studies are: 1) the present shuttle treadmill running surface would not suffice if one wanted to run with a natural style at levels greater than 0.6 G; 2) in terms of attempting to replicate typical ground reaction force profiles during locomotor exercise at reduced gravity levels, it appears as though it is easier to match the peak rates of change of force (maxDFDT) than it is to match values for the peak force magnitudes (maxGRF). PMID:8338506

  11. EFL/ESL Textbook Selection in Korea and East Asia - Relevant Issues and Literature Review

    NASA Astrophysics Data System (ADS)

    Meurant, Robert C.

    EFL/ESL departments periodically face the problem of textbook selection. Cogent issues are that non-native speakers will use L2 English mainly to communicate with other non-native English speakers, so an American accent is becoming less important. L2 English will mainly be used in computer-mediated communication, hence the importance of L2 Digital Literacy. The convergence of Information Communication Technologies is radically impacting Second Language Acquisition, which is integrating web-hosted Assessment and Learning Management Systems. EFL/ESL textbooks need to be compatible with blended learning, prepare students for a globalized world, and foster autonomous learning. I summarize five papers on EFL/ESL textbook evaluation and selection, and include relevant material for adaptation. Textbooks are major sources of contact with the target language, so selection is an important decision. Educators need to be systematic and objective in their approach, adopting a selection process that is open, transparent, accountable, participatory, informed and rigorous.

  12. A review on technologies and their usage in solid waste monitoring and management systems: Issues and challenges

    SciTech Connect

    Hannan, M.A.; Abdulla Al Mamun, Md.; Hussain, Aini; Basri, Hassan; Begum, R.A.

    2015-09-15

    Highlights: • Classification of available technologies for SWM system in four core category. • Organization of technology based SWM systems in three main groups. • Summary of SWM systems with target application, methodology and functional domain. • Issues and challenges are highlighted for further design of a sustainable system. - Abstract: In the backdrop of prompt advancement, information and communication technology (ICT) has become an inevitable part to plan and design of modern solid waste management (SWM) systems. This study presents a critical review of the existing ICTs and their usage in SWM systems to unfold the issues and challenges towards using integrated technologies based system. To plan, monitor, collect and manage solid waste, the ICTs are divided into four categories such as spatial technologies, identification technologies, data acquisition technologies and data communication technologies. The ICT based SWM systems classified in this paper are based on the first three technologies while the forth one is employed by almost every systems. This review may guide the reader about the basics of available ICTs and their application in SWM to facilitate the search for planning and design of a sustainable new system.

  13. [Literature review of the influences on error rates when identifying equids with transponder and hot-iron branding].

    PubMed

    Campe, Amely; Schulz, Sophia; Bohnet, Willa

    2016-01-01

    Although equids have had to be tagged with a transponder since 2009, breeding associations in Germany disagree as to which method is best suited for identification (with or without hot iron branding). Therefore, the aim of this systematic literature review was to gain an overview of how effective identification is using transponders and hot iron branding and as to which factors influence the success of identification. Existing literature showed that equids can be identified by means of transponders with a probability of 85-100%, whereas symbol brandings could be identified correctly in 78-89%, whole number brandings in 0-87% and single figures in 37-92% of the readings, respectively. The successful reading of microchips can be further optimised by a correctly operated implantation process and thorough training of the applying persons. affect identification with a scanner. The removal of transponders for manipulation purposes is virtually impossible. Influences during the application of branding marks can hardly, if at all, be standardised, but influence the subsequent readability relevantly. Therefore, identification by means of hot branding cannot be considered sufficiently reliable. Impaired quality of identification can be reduced during reading but cannot be counteracted. Based on the existing studies it can be concluded that the transponder method is the best suited of the investigated methods for clearly identifying equids, being forgery-proof and permanent. It is not to be expected that applying hot branding in addition to microchips would optimise the probability of identification relevantly. PMID:26904892

  14. A Review of Fetal ECG Signal Processing; Issues and Promising Directions

    PubMed Central

    Sameni, Reza; Clifford, Gari D.

    2010-01-01

    The field of electrocardiography has been in existence for over a century, yet despite significant advances in adult clinical electrocardiography, signal processing techniques and fast digital processors, the analysis of fetal ECGs is still in its infancy. This is, partly due to a lack of availability of gold standard databases, partly due to the relatively low signal-to-noise ratio of the fetal ECG compared to the maternal ECG (caused by the various media between the fetal heart and the measuring electrodes, and the fact that the fetal heart is simply smaller), and in part, due to the less complete clinical knowledge concerning fetal cardiac function and development. In this paper we review a range of promising recording and signal processing techniques for fetal ECG analysis that have been developed over the last forty years, and discuss both their shortcomings and advantages. Before doing so, however, we review fetal cardiac development, and the etiology of the fetal ECG. A selection of relevant models for the fetal/maternal ECG mixture is also discussed. In light of current understanding of the fetal ECG, we then attempt to justify recommendations for promising future directions in signal processing, and database creation. PMID:21614148

  15. Infantile autism and childhood schizophrenia: review of the issues from the sociocultural point of view.

    PubMed

    Sanua, V D

    1983-01-01

    After presenting an historical overview of the development of the concept of childhood psychosis, this paper discusses the various etiologies which have been offered to explain severe disturbances of childhood. Reference is made to the nature/nurture polemic. In spite of the general belief that the etiology is biologically determined, particularly in infantile autism, the actual evidence tends to be meagre. Furthermore, the literature includes a number of studies which have been found to be methodically weak and which seem to disclaim the intellectual and socioeconomic superiority of the parents of autistic children, contrary to Kanner's original finding that such superiority exists. The link between social class and autism, according to Cantwell's review, does not appear to fit a purely biological causation of autism. This remains an awkward finding which still demands an explanation. The contention of this paper is that contradictory findings could be explained, as stated by Kanner, by the 'inordinate' use of the label 'autism' to include various types of children's severe disorders, even brain-damaged children. Furthermore this review emphasizes the fact that a total neglect of sociocultural variables in the study of such children has led to confounding results. A careful reading of the literature and correspondence with numerous psychiatrists around the world have led the author to believe that infantile autism is more prevalent in highly technological countries where there is extensive geographical and economic mobility coupled with the nuclearization of the family. This paper offers supportive evidence for this speculation. PMID:6359455

  16. Quantum mechanics of excitation transport in photosynthetic complexes: a key issues review.

    PubMed

    Levi, Federico; Mostarda, Stefano; Rao, Francesco; Mintert, Florian

    2015-07-01

    For a long time microscopic physical descriptions of biological processes have been based on quantum mechanical concepts and tools, and routinely employed by chemical physicists and quantum chemists. However, the last ten years have witnessed new developments on these studies from a different perspective, rooted in the framework of quantum information theory. The process that more, than others, has been subject of intense research is the transfer of excitation energy in photosynthetic light-harvesting complexes, a consequence of the unexpected experimental discovery of oscillating signals in such highly noisy systems. The fundamental interdisciplinary nature of this research makes it extremely fascinating, but can also constitute an obstacle to its advance. Here in this review our objective is to provide an essential summary of the progress made in the theoretical description of excitation energy dynamics in photosynthetic systems from a quantum mechanical perspective, with the goal of unifying the language employed by the different communities. This is initially realized through a stepwise presentation of the fundamental building blocks used to model excitation transfer, including protein dynamics and the theory of open quantum system. Afterwards, we shall review how these models have evolved as a consequence of experimental discoveries; this will lead us to present the numerical techniques that have been introduced to quantitatively describe photo-absorbed energy dynamics. Finally, we shall discuss which mechanisms have been proposed to explain the unusual coherent nature of excitation transport and what insights have been gathered so far on the potential functional role of such quantum features. PMID:26194028

  17. Quantum mechanics of excitation transport in photosynthetic complexes: a key issues review

    NASA Astrophysics Data System (ADS)

    Levi, Federico; Mostarda, Stefano; Rao, Francesco; Mintert, Florian

    2015-07-01

    For a long time microscopic physical descriptions of biological processes have been based on quantum mechanical concepts and tools, and routinely employed by chemical physicists and quantum chemists. However, the last ten years have witnessed new developments on these studies from a different perspective, rooted in the framework of quantum information theory. The process that more, than others, has been subject of intense research is the transfer of excitation energy in photosynthetic light-harvesting complexes, a consequence of the unexpected experimental discovery of oscillating signals in such highly noisy systems. The fundamental interdisciplinary nature of this research makes it extremely fascinating, but can also constitute an obstacle to its advance. Here in this review our objective is to provide an essential summary of the progress made in the theoretical description of excitation energy dynamics in photosynthetic systems from a quantum mechanical perspective, with the goal of unifying the language employed by the different communities. This is initially realized through a stepwise presentation of the fundamental building blocks used to model excitation transfer, including protein dynamics and the theory of open quantum system. Afterwards, we shall review how these models have evolved as a consequence of experimental discoveries; this will lead us to present the numerical techniques that have been introduced to quantitatively describe photo-absorbed energy dynamics. Finally, we shall discuss which mechanisms have been proposed to explain the unusual coherent nature of excitation transport and what insights have been gathered so far on the potential functional role of such quantum features.

  18. Working but Poor in America. AFL-CIO Reviews the Issues. Report No. 84.

    ERIC Educational Resources Information Center

    Parente, Frank

    In 1993, 10.4 million people were classified as being among the working poor. Of those individuals living in poverty, 2.4 million worked year round at full-time jobs and 7.4 million lived in a household containing someone who was employed full time throughout the year. A U.S. Bureau of Labor Statistics report identified low earnings, involuntary…

  19. Literature review to identify factors that support implementation of evidence-based practice in residential aged care.

    PubMed

    Masso, Malcolm; McCarthy, Grace

    2009-06-01

    The aim was to undertake a review of the literature on change management, quality improvement, evidence-based practice and diffusion of innovations to identify key factors that might influence the uptake and continued use of evidence in residential aged care. The key factors will be used to shape and inform the evaluation of the Encouraging Best Practice in Residential Aged Care Program which commenced in Australia in 2007. MEDLINE, CINAHL and the Cochrane Database of Systematic Reviews were searched using combinations of search terms. Searching focused on existing literature reviews, discussions of relevant conceptual and theoretical frameworks and primary studies that have examined the implementation of evidence-based practice in residential aged care. Keyword searching was supplemented with snowball searching (following up on the references cited in the papers identified by the search), searching by key authors in the field and hand searching of a small number of journals. In general, the period covered by the searches was from 2002 to 2008. The findings from the literature are often equivocal. Analysis and consolidation of factors derived from the literature that might influence the implementation of evidence-based practice resulted in the identification of eight factors: (i) a receptive context for change; (ii) having a model of change to guide implementation; (iii) adequate resources; (iv) staff with the necessary skills; (v) stakeholder engagement, participation and commitment; (vi) the nature of the change in practice; (vii) systems in place to support the use of evidence; and (viii) demonstrable benefits of the change. Most of the literature included in the review is from studies in healthcare and hence the generalisability to residential aged care is largely unknown. However, the focus of this research is on clinical care, within the context of residential aged care, hence the healthcare literature is relevant. The factors are relatively broad and cover

  20. Contemporary issues concerning informed consent in Japan based on a review of court decisions and characteristics of Japanese culture

    PubMed Central

    2014-01-01

    Background Since Japan adopted the concept of informed consent from the West, its inappropriate acquisition from patients in the Japanese clinical setting has continued, due in part to cultural aspects. Here, we discuss the current status of and contemporary issues surrounding informed consent in Japan, and how these are influenced by Japanese culture. Discussion Current legal norms towards informed consent and information disclosure are obscure in Japan. For instance, physicians in Japan do not have a legal duty to inform patients of a cancer diagnosis. To gain a better understanding of these issues, we present five court decisions related to informed consent and information disclosure. We then discuss Japanese culture through reviews of published opinions and commentaries regarding how culture affects decision making and obtaining informed consent. We focus on two contemporary problems involving informed consent and relevant issues in clinical settings: the misuse of informed consent and persistence in obtaining consent. For the former issue, the phrase "informed consent" is often used to express an opportunity to disclose medical conditions and recommended treatment choices. The casual use of the expression "informed consent" likely reflects deep-rooted cultural influences. For the latter issue, physicians may try to obtain a signature by doing whatever it takes, lacking a deep understanding of important ethical principles, such as protecting human dignity, serving the patient’s best interest, and doing no harm in decision-making for patients. There is clearly a misunderstanding of the concept of informed consent and a lack of complete understanding of ethical principles among Japanese healthcare professionals. Although similar in some respects to informed consent as it originated in the United States, our review makes it clear that informed consent in Japan has clear distinguishing features. Summary Japanese healthcare professionals should aim to understand

  1. Horizontal gaze nystagmus: a review of vision science and application issues.

    PubMed

    Rubenzer, Steven J; Stevenson, Scott B

    2010-03-01

    The Horizontal Gaze Nystagmus (HGN) test is one component of the Standardized Field Sobriety Test battery. This article reviews the literature on smooth pursuit eye movement and gaze nystagmus with a focus on normative responses, the influence of alcohol on these behaviors, and stimulus conditions similar to those used in the HGN sobriety test. Factors such as age, stimulus and background conditions, medical conditions, prescription medications, and psychiatric disorder were found to affect the smooth pursuit phase of HGN. Much less literature is available for gaze nystagmus, but onset of nystagmus may occur in some sober subjects at 45 degrees or less. We conclude that HGN is limited by large variability in the underlying normative behavior, from methods and testing environments that are often poorly controlled, and from a lack of rigorous validation in laboratory settings. PMID:20102467

  2. Dematerialization and Deformalization of the EFL/ESL Textbook - Literature Review and Relevant Issues

    NASA Astrophysics Data System (ADS)

    Meurant, Robert C.

    Rapid development and critical convergence of Information Communication Technologies is radically impacting education, particularly in second language acquisition, where the sudden availability of multimedia content and immediacy of distance communication offer specific advantage. The language classroom is evolving to integrate computer-mediated learning and communication with traditional schooling; digitization and the Internet mean the textbook is evolving from inert hard copy that is consumed, to dynamic e-texts that students participate in. The emergence of English as a Global Language, with the primary role of English on the Internet, means that the transition from fixed hard copy to fluid online digital environment is particularly evident in EFL/ESL. I review research, trace ways in which this transition occurs, and speculate on how, under the impact of ICTs and their convergence, the EFL/ESL textbook will reform, and may even disappear as a stand-alone entity.

  3. Review of wet environment types on Mars with focus on duration and volumetric issues.

    PubMed

    Kereszturi, Akos

    2012-06-01

    The astrobiological significance of certain environment types on Mars strongly depends on the temperature, duration, and chemistry of liquid water that was present there in the past. Recent works have focused on the identification of signs of ancient water on Mars, as it is more difficult to estimate the above-mentioned parameters. In this paper, two important factors are reviewed, the duration and the volume of water at different environment types on past and present Mars. Using currently available information, we can only roughly estimate these values, but as environment types show characteristic differences in this respect, it is worth comparing them and the result may have importance for research in astrobiology. Impact-induced and geothermal hydrothermal systems, lakes, and valley networks were in existence on Mars over the course of from 10(2) to 10(6) years, although they would have experienced substantially different temperature regimes. Ancient oceans, as well as water in outflow channels and gullies, and at the microscopic scale as interfacial water layers, would have had inherently different times of duration and overall volume: oceans may have endured from 10(4) to 10(6) years, while interfacial water would have had the smallest volume and residence time of liquid phase on Mars. Martian wet environments with longer residence times of liquid water are believed to have existed for that amount of time necessary for life to develop on Earth between the Late Heavy Bombardment and the age of the earliest fossil record. The results of this review show the necessity for more detailed analysis of conditions within geothermal heat-induced systems to reconstruct the conditions during weathering and mineral alteration, as well as to search for signs of reoccurring wet periods in ancient crater lakes. PMID:22794300

  4. Robotic invasion of operation theatre and associated anaesthetic issues: A review.

    PubMed

    Kakar, Prem N; Das, Jyotirmoy; Roy, Preeti Mittal; Pant, Vijaya

    2011-01-01

    A Robotic device is a powered, computer controlled manipulator with artificial sensing that can be reprogrammed to move and position tools to carry out a wide range of tasks. Robots and Telemanipulators were first developed by the National Aeronautics and Space Administration (NASA) for use in space exploration. Today's medical robotic systems were the brainchild of the United States Department of Defence's desire to decrease war casualties with the development of 'telerobotic surgery'. The 'master-slave' telemanipulator concept was developed for medical use in the early 1990s where the surgeon's (master) manual movements were transmitted to end-effector (slave) instruments at a remote site. Since then, the field of surgical robotics has undergone massive transformation and the future is even brighter. As expected, any new technique brings with it risks and the possibility of technical difficulties. The person who bears the brunt of complications or benefit from a new invention is the 'Patient'. Anaesthesiologists as always must do their part to be the patient's 'best man' in the perioperative period. We should be prepared for screening and selection of patients in a different perspective keeping in mind the steep learning curves of surgeons, long surgical hours, extreme patient positioning and other previously unknown anaesthetic challenges brought about by the surgical robot. In this article we have tried to track the development of surgical robots and consider the unique anaesthetic issues related to robot assisted surgeries. PMID:21431048

  5. Robotic invasion of operation theatre and associated anaesthetic issues: A review

    PubMed Central

    Kakar, Prem N; Das, Jyotirmoy; Roy, Preeti Mittal; Pant, Vijaya

    2011-01-01

    A Robotic device is a powered, computer controlled manipulator with artificial sensing that can be reprogrammed to move and position tools to carry out a wide range of tasks. Robots and Telemanipulators were first developed by the National Aeronautics and Space Administration (NASA) for use in space exploration. Today’s medical robotic systems were the brainchild of the United States Department of Defence’s desire to decrease war casualties with the development of ‘telerobotic surgery’. The ‘master-slave’ telemanipulator concept was developed for medical use in the early 1990s where the surgeon’s (master) manual movements were transmitted to end-effector (slave) instruments at a remote site. Since then, the field of surgical robotics has undergone massive transformation and the future is even brighter. As expected, any new technique brings with it risks and the possibility of technical difficulties. The person who bears the brunt of complications or benefit from a new invention is the ‘Patient’. Anaesthesiologists as always must do their part to be the patient’s ‘best man’ in the perioperative period. We should be prepared for screening and selection of patients in a different perspective keeping in mind the steep learning curves of surgeons, long surgical hours, extreme patient positioning and other previously unknown anaesthetic challenges brought about by the surgical robot. In this article we have tried to track the development of surgical robots and consider the unique anaesthetic issues related to robot assisted surgeries. PMID:21431048

  6. Cobenefits of replacing car trips with alternative transportation: a review of evidence and methodological issues.

    PubMed

    Xia, Ting; Zhang, Ying; Crabb, Shona; Shah, Pushan

    2013-01-01

    It has been reported that motor vehicle emissions contribute nearly a quarter of world energy-related greenhouse gases and cause nonnegligible air pollution primarily in urban areas. Reducing car use and increasing ecofriendly alternative transport, such as public and active transport, are efficient approaches to mitigate harmful environmental impacts caused by a large amount of vehicle use. Besides the environmental benefits of promoting alternative transport, it can also induce other health and economic benefits. At present, a number of studies have been conducted to evaluate cobenefits from greenhouse gas mitigation policies. However, relatively few have focused specifically on the transport sector. A comprehensive understanding of the multiple benefits of alternative transport could assist with policy making in the areas of transport, health, and environment. However, there is no straightforward method which could estimate cobenefits effect at one time. In this paper, the links between vehicle emissions and air quality, as well as the health and economic benefits from alternative transport use, are considered, and methodological issues relating to the modelling of these cobenefits are discussed. PMID:23956758

  7. Cobenefits of Replacing Car Trips with Alternative Transportation: A Review of Evidence and Methodological Issues

    PubMed Central

    Zhang, Ying; Crabb, Shona

    2013-01-01

    It has been reported that motor vehicle emissions contribute nearly a quarter of world energy-related greenhouse gases and cause nonnegligible air pollution primarily in urban areas. Reducing car use and increasing ecofriendly alternative transport, such as public and active transport, are efficient approaches to mitigate harmful environmental impacts caused by a large amount of vehicle use. Besides the environmental benefits of promoting alternative transport, it can also induce other health and economic benefits. At present, a number of studies have been conducted to evaluate cobenefits from greenhouse gas mitigation policies. However, relatively few have focused specifically on the transport sector. A comprehensive understanding of the multiple benefits of alternative transport could assist with policy making in the areas of transport, health, and environment. However, there is no straightforward method which could estimate cobenefits effect at one time. In this paper, the links between vehicle emissions and air quality, as well as the health and economic benefits from alternative transport use, are considered, and methodological issues relating to the modelling of these cobenefits are discussed. PMID:23956758

  8. Renormalization group invariance and optimal QCD renormalization scale-setting: a key issues review

    NASA Astrophysics Data System (ADS)

    Wu, Xing-Gang; Ma, Yang; Wang, Sheng-Quan; Fu, Hai-Bing; Ma, Hong-Hao; Brodsky, Stanley J.; Mojaza, Matin

    2015-12-01

    A valid prediction for a physical observable from quantum field theory should be independent of the choice of renormalization scheme—this is the primary requirement of renormalization group invariance (RGI). Satisfying scheme invariance is a challenging problem for perturbative QCD (pQCD), since a truncated perturbation series does not automatically satisfy the requirements of the renormalization group. In a previous review, we provided a general introduction to the various scale setting approaches suggested in the literature. As a step forward, in the present review, we present a discussion in depth of two well-established scale-setting methods based on RGI. One is the ‘principle of maximum conformality’ (PMC) in which the terms associated with the β-function are absorbed into the scale of the running coupling at each perturbative order; its predictions are scheme and scale independent at every finite order. The other approach is the ‘principle of minimum sensitivity’ (PMS), which is based on local RGI; the PMS approach determines the optimal renormalization scale by requiring the slope of the approximant of an observable to vanish. In this paper, we present a detailed comparison of the PMC and PMS procedures by analyzing two physical observables R e+e- and Γ(H\\to b\\bar{b}) up to four-loop order in pQCD. At the four-loop level, the PMC and PMS predictions for both observables agree within small errors with those of conventional scale setting assuming a physically-motivated scale, and each prediction shows small scale dependences. However, the convergence of the pQCD series at high orders, behaves quite differently: the PMC displays the best pQCD convergence since it eliminates divergent renormalon terms; in contrast, the convergence of the PMS prediction is questionable, often even worse than the conventional prediction based on an arbitrary guess for the renormalization scale. PMC predictions also have the property that any residual dependence on

  9. A review on biomass classification and composition, cofiring issues and pretreatment methods

    SciTech Connect

    Jaya Shankar Tumuluru; Shahab Sokhansanj; Christopher T. Wright; Richard D. Boardman

    2011-08-01

    Presently around the globe there is a significant interest in using biomass for power generation as power generation from coal continues to raise environmental concerns. Biomass alone can be used for generation of power which can bring lot of environmental benefits. However the constraints of using biomass alone can include high investments costs for biomass feed systems and also uncertainty in the security of the feedstock supply due to seasonal variations and in most of the countries biomass is dispersed and the infrastructure for biomass supply is not well established. Alternatively cofiring biomass along with coal offer advantages like (a) reducing the issues related to biomass quality and buffers the system when there is insufficient feedstock quantity and (b) costs of adapting the existing coal power plants will be lower than building new systems dedicated only to biomass. However with the above said advantages there exists some technical constrains including low heating and energy density values, low bulk density, lower grindability index, higher moisture and ash content to successfully cofire biomass with coal. In order to successfully cofire biomass with coal, biomass feedstock specifications need to be established to direct pretreatment options that may include increasing the energy density, bulk density, stability during storage and grindability. Impacts on particle transport systems, flame stability, pollutant formation and boiler tube fouling/corrosion must also be minimized by setting feedstock specifications including composition and blend ratios if necessary. Some of these limitations can be overcome by using pretreatment methods. This paper discusses the impact of feedstock pretreatment methods like sizing, baling, pelletizing, briquetting, washing/leaching, torrefaction, torrefaction and pelletization and steam explosion in attainment of optimum feedstock characteristics to successfully cofire biomass with coal.

  10. Prescription privileges for psychologists: a comprehensive review and critical analysis of current issues and controversies.

    PubMed

    Lavoie, Kim L; Barone, Silvana

    2006-01-01

    The debate over whether clinical psychologists should be granted the right to prescribe psychoactive medications has received considerable attention over the past 2 decades in North America and, more recently, in the UK. Proponents of granting prescription privileges to clinical psychologists argue that mental healthcare services are in crisis and that the mental health needs of society are not being met. They attribute this crisis primarily to the inappropriate prescribing practices of general practitioners and a persistent shortage of psychiatrists. It is believed that, as they would increase the scope of the practice of psychology, prescription privileges for psychologists would enhance mental health services by increasing public access to qualified professionals who are able to prescribe. The profession of psychology remains divided on the issue, and opponents have been equally outspoken in their arguments. The purpose of the present article is to place the pursuit of prescription privileges for psychologists in context by discussing the historical antecedents and major forces driving the debate. The major arguments put forth for and against prescription privileges for psychologists are presented, followed by a critical analysis of the validity and coherence of those arguments. Through this analysis, the following question is addressed. Is there currently sufficient empirical support for the desirability, feasibility, safety and cost effectiveness of granting prescription privileges to psychologists? Although proponents of granting prescription privileges to psychologists present several compelling arguments in favour of this practice, there remains a consistent lack of empirical evidence for the desirability, feasibility, safety and cost effectiveness of this proposal. More research is needed before we can conclude that prescription privileges for psychologists are a safe and logical solution to the problems facing the mental healthcare system. PMID:16396524

  11. NRC staff review of licensee responses to pressure-locking and thermal-binding issue

    SciTech Connect

    Rathbun, H.J.

    1996-12-01

    Commercial nuclear power plant operating experience has indicated that pressure locking and thermal binding represent potential common mode failure mechanisms that can cause safety-related power-operated gate valves to fail in the closed position, thus rendering redundant safety-related systems incapable of performing their safety functions. In Generic Letter (GL) 95-07, {open_quotes}Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves,{close_quotes} the U.S. Nuclear Regulatory Commission (NRC) staff requested that nuclear power plant licensees take certain actions to ensure that valves susceptible to pressure locking or thermal binding are capable of performing their safety functions within the current licensing bases of the facility. The NRC staff has received summary information from licensees in response to GL 95-07 describing actions they have taken to prevent the occurrence of pressure locking and thermal binding. The NRC staff has developed a systematic process to help ensure uniform and consistent review of licensee submittals in response to GL 95-07.

  12. A review of contamination issues associated with an orbiting Space Station external environment

    NASA Technical Reports Server (NTRS)

    Smith, A. C.

    1985-01-01

    Techniques for measuring, modeling, and limiting the effluent contamination of external spacecraft and instrument surfaces are reviewed, with an emphasis on their application to the Space Station. The major factors addressed by contamination studies are outlined; typical contamination sources are characterized; the critical measurement parameters are defined (molecular column density, background spectral intensity from UV to IR, particle size and velocity distribution, molecular deposition on ambient and cryogenic surfaces, molecular return flux for gaseous species, particulate deposition on surfaces, and optical-surface degradation); and measurement instrumentation is described. Contamination limits for quiescent operation periods of the Space Station are proposed, including column density 10 to the 11th/sq cm for H2O + CO2, 10 to the 13th/sq cm for O2 + N2, and 10 to the 10th/sq cm for other species; particle release no greater than 15-micron particle/orbit/0.00001 sr FOV for a 1-m telescope, and surface deposition 4 pg/sq cm sec for 298-K surfaces and 10 pg/sq cm sec for 4-K surfaces.

  13. Multi-resolution simulation of biomolecular systems: a review of methodological issues.

    PubMed

    Meier, Katharina; Choutko, Alexandra; Dolenc, Jozica; Eichenberger, Andreas P; Riniker, Sereina; van Gunsteren, Wilfred F

    2013-03-01

    Theoretical-computational modeling with an eye to explaining experimental observations in regard to a particular chemical phenomenon or process requires choices concerning essential degrees of freedom and types of interactions and the generation of a Boltzmann ensemble or trajectories of configurations. Depending on the degrees of freedom that are essential to the process of interest, for example, electronic or nuclear versus atomic, molecular or supra-molecular, quantum- or classical-mechanical equations of motion are to be used. In multi-resolution simulation, various levels of resolution, for example, electronic, atomic, supra-atomic or supra-molecular, are combined in one model. This allows an enhancement of the computational efficiency, while maintaining sufficient detail with respect to particular degrees of freedom. The basic challenges and choices with respect to multi-resolution modeling are reviewed and as an illustration the differential catalytic properties of two enzymes with similar folds but different substrates with respect to these substrates are explored using multi-resolution simulation at the electronic, atomic and supra-molecular levels of resolution. PMID:23417997

  14. Fitness for duty in the nuclear power industry: A review of technical issues

    SciTech Connect

    Barnes, V.; Fleming, I.; Grant, T.; Hauth, J.; Hendrickson, J.; Kono, B.; Moore, C.; Olson, J.; Saari, L.; Toquam, J.; Wieringa, D.; Yost, P.; Hendrickson, P.; Moon, D.; Scott, W.

    1988-09-01

    This report presents information gathered and analyzed in support of the United States Nuclear Regulatory Commission's (NRC's) efforts to develop a rule that will ensure that workers with unescorted access to protected areas in nuclear power plants are fit for duty. The primary potential fitness-for-duty concern addressed in the report is impairment caused by substance abuse, although other sources of impairment on the job are discussed. The report examines the prevalence of fitness-for-duty problems and discusses the use and effects of illicit drugs, prescription drugs, over-the-counter preparations and alcohol. The ways in which fitness-for-duty concerns are being addressed in both public- and private-sector industries are reviewed, and a description is provided of fitness-for-duty practices in six organizations that, like the nuclear industry, are regulated and whose operations can affect public health and safety. Methods of ensuring fitness for duty in the nuclear industry are examined in detail. The report also addresses methods of evaluating the effectiveness of fitness-for-duty programs in the nuclear power industry.

  15. Qualitative Risk Assessment for an LNG Refueling Station and Review of Relevant Safety Issues

    SciTech Connect

    Siu, N.; Herring, J.S.; Cadwallader, L.; Reece, W.; Byers, J.

    1998-02-01

    This report is a qualitative assessment of the public and worker risk involved with the operation of a liquefied natural gas (LNG) vehicle refueling facility. This study includes facility maintenance and operations, tank truck deliveries, and end-use vehicle fueling; it does not treat the risks of LNG vehicles on roadways. Accident initiating events are identified by using a Master Logic Diagram, a Failure Modes and Effects Analysis, and historical operating experiences. The event trees were drawn to depict possible sequences of mitigating events following the initiating events. The phenomenology of LNG and other vehicle fuels is discussed to characterize the hazard posed by LNG usage. Based on the risk modeling and analysis, recommendations are given to improve the safety of LNG refueling stations in the areas of procedures and training, station design, and the dissemination of ``best practice`` information throughout the LNG community.

  16. Interim qualitative risk assessment for an LNG refueling station and review of relevant safety issues

    SciTech Connect

    Siu, N.; Herring, S.; Cadwallader, L.; Reece, W.; Byers, J.

    1997-07-01

    This report is a qualitative assessment of the public and worker risk involved with the operation of a liquefied natural (LNG) vehicle refueling facility. This study includes facility maintenance and operations, tanker truck delivers and end-use vehicle fueling; it does not treat the risks of LNG vehicles on roadways. Accident initiating events are identified by using a Master Logic Diagram, a Failure Modes and Effects analysis and historical operating experiences. The event trees were drawn to depict possible sequences of mitigating events following the initiating events. The phenomenology of LNG and other vehicle fuels is discussed to characterize the hazard posed by LNG usage. Based on the risk modeling and analysis, recommendations are given to improve the safety of LNG refueling stations in the areas of procedures and training, station design, and the dissemination of best practice information throughout the LNG community.

  17. Sexuality in eating disorders patients: etiological factors, sexual dysfunction and identity issues. A systematic review.

    PubMed

    Castellini, Giovanni; Lelli, Lorenzo; Ricca, Valdo; Maggi, Mario

    2016-02-01

    The scientific community appears to be less interested in sexuality of eating disorders (EDs) as compared to other psychiatric or medical comorbidities. However, a clear association between sexual problems and ED psychopathology was reported from different perspectives. The overarching goal of this systematic review was to evaluate the general approach of the scientific literature toward the topic of sexuality and EDs. In particular, four different categories of research have been individuated, encompassing the role of puberty, and sexual abuse in the pathogenesis of the disorders, sexual dysfunctions, and the association between sexual orientation and EDs psychopathology. Timing of puberty with its hormonal consequences and the changes in the way persons perceive their own body represent a crucial period of life for the onset of the disorder. Sexual abuse, and especially childhood sexual abuse are well-recognized risk factors for the development of ED, determining a worse long-term outcome. Recent research overcome the approach that considers sexual activity of EDs patients, in terms of hypersexuality and dangerous sexual behaviors, considering the sexuality of EDs persons in terms of sexual desire, satisfaction, orgasm and pain. Results from this line of research are promising, and describe a clear relationship between sexual dysfunction and the core psychopathological features of EDs, such as body image disturbances. Finally, the analysis of the literature showed an association between sexual orientation and gender dysphoria with EDs psychopathology and pathological eating behaviors, confirming the validity of research developing new models of maintaining factors of EDs related to the topic of self-identity. PMID:26812878

  18. A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker.

    PubMed

    Heinzelmann-Schwarz, Viola A; Nixdorf, Sheri; Valadan, Mehrnaz; Diczbalis, Monica; Olivier, Jake; Otton, Geoff; Fedier, André; Hacker, Neville F; Scurry, James P

    2014-04-01

    Vulvar melanoma is the second most common vulvar cancer. Patients with vulvar melanoma usually present with the disease at a late stage and have a poor prognosis. The prognostic predictors reported in the literature are not unequivocal and the role of lichen sclerosus and c-KIT mutations in the aetiology of vulvar melanoma is unclear. Breslow staging currently seems to be the most adequate predictor of prognosis. We thus performed a clinicopathological and literature review to identify suitable predictors of prognosis and survival and investigated the expression of c-KIT (by immunohistochemistry) in patients with vulvar melanoma (n=33) from the Gynaecological Cancer Centres of the Royal Hospital for Women (Sydney, Australia) and John Hunter Hospital (Newcastle, Australia). Our series of 33 patients fitted the expected clinical profile of older women: delayed presentation, high stage, limited response to treatment and poor prognosis. We identified 3 patients (9.1%) with lichen sclerosus associated with melanoma in situ, although no lichen sclerosus was found in the areas of invasive melanoma. No patient had vulvar nevi. We identified a) Breslow's depth, b) an absence of any of the pathological risk factors, such as satellitosis, in-transit metastasis, lymphovascular space invasion (LVSI) and dermal mitosis, c) removal of inguino-femoral lymph nodes, d) lateral margin of >1 cm, and e) c-KIT expression as valuable prognostic predictors for disease-free survival. We conclude that c-KIT expression is, apart from Breslow's depth, another valuable predictor of prognosis and survival. Lichen sclerosus may be associated with vulvar melanoma. PMID:24535703

  19. A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker

    PubMed Central

    HEINZELMANN-SCHWARZ, VIOLA A.; NIXDORF, SHERI; VALADAN, MEHRNAZ; DICZBALIS, MONICA; OLIVIER, JAKE; OTTON, GEOFF; FEDIER, ANDRÉ; HACKER, NEVILLE F.; SCURRY, JAMES P.

    2014-01-01

    Vulvar melanoma is the second most common vulvar cancer. Patients with vulvar melanoma usually present with the disease at a late stage and have a poor prognosis. The prognostic predictors reported in the literature are not unequivocal and the role of lichen sclerosus and c-KIT mutations in the aetiology of vulvar melanoma is unclear. Breslow staging currently seems to be the most adequate predictor of prognosis. We thus performed a clinicopathological and literature review to identify suitable predictors of prognosis and survival and investigated the expression of c-KIT (by immunohistochemistry) in patients with vulvar melanoma (n=33) from the Gynaecological Cancer Centres of the Royal Hospital for Women (Sydney, Australia) and John Hunter Hospital (Newcastle, Australia). Our series of 33 patients fitted the expected clinical profile of older women: delayed presentation, high stage, limited response to treatment and poor prognosis. We identified 3 patients (9.1%) with lichen sclerosus associated with melanoma in situ, although no lichen sclerosus was found in the areas of invasive melanoma. No patient had vulvar nevi. We identified a) Breslow’s depth, b) an absence of any of the pathological risk factors, such as satellitosis, in-transit metastasis, lymphovascular space invasion (LVSI) and dermal mitosis, c) removal of inguino-femoral lymph nodes, d) lateral margin of >1 cm, and e) c-KIT expression as valuable prognostic predictors for disease-free survival. We conclude that c-KIT expression is, apart from Breslow’s depth, another valuable predictor of prognosis and survival. Lichen sclerosus may be associated with vulvar melanoma. PMID:24535703

  20. Why do few food-allergic adolescents treat anaphylaxis with adrenaline?--Reviewing a pressing issue.

    PubMed

    Marrs, Tom; Lack, Gideon

    2013-05-01

    Food allergic adolescents are at higher risk of fatal anaphylaxis than other children. Both allergen avoidance and maintaining access to adrenaline auto-injectors (AAI) are key goals in effective food allergy management, for which written guidance is often supplied. However, adolescents are rarely sufficiently prepared to use adrenaline during anaphylaxis. It is likely that further didactic education would bring limited improvement in management in this population. Focused discussion of each adolescent's perspectives and current management practice may allow more effective behavioural strategies to be adopted. Key areas for appraisal include subjects' experiences after previous allergen exposure with reference to worst response, recognising specific symptoms requiring AAI administration, and appropriate priority being given to timeliness of administering adrenaline. Behavioural strategies should be discussed to increase AAI accessibility. Rigor of allergen avoidance should not be compromised by false reassurance of proximity to emergency medication or medical services. Food allergic adolescents are motivated by the psychological impact of their condition, which often makes them feel different to their peers and may result in bullying. Methods of appropriately empowering adolescents may be considered, such as involvement of close friends and lay organisations to support appropriate management. Open discussion is crucial in engaging with adolescents' reasoning for adopting their chosen management strategies. Further research is warranted to identify cognitive patterns associated with high-risk behaviour, and to design appropriate interventions for the augmentation of adolescent self-management skills. PMID:23173610

  1. Summary review of health effects associated with naphthalene: health issue assessment

    SciTech Connect

    Not Available

    1987-11-01

    Naphthalene is released into ambient air via industrial gaseous and particulate emissions, tobacco use, and through consumer use. The data base concerning exposure of humans via inhalation and associated health effects is virtually nonexistent. Overexposure often results in acute hemolytic anemia and has been associated with cataract formation. There are no available dose-response data. In laboratory animals, two principal target tissues have been identified: non-ciliated bronchiolar epithelial (Clara) cells and eye tissue. The metabolite(s) responsible for Clara cell damage is unknown. There are no published studies involving inhalation exposure. Administration of naphthalene by routes other than inhalation has been shown to produce cataracts in rats, rabbits, and one mouse strain. Animal strains with pigmented eyes develop cataracts faster and more severely than albino strains. The likely causative agent is polyphenol oxydase, found only in pigmented eyes, that catalyzes the formation of 1,2-naphthoquione which binds to lens tissue. Negative results have been reported for gene mutations (Salmonella), unscheduled DNA synthesis in rat hepatocytes and microneuclei in mouse bone marrow. Limited teratology studies in rats and rabbits reported no gross abnormalities. In a single dose (300 mg/kg) study in mice, both maternal and fetal toxicity were reported.

  2. Healthcare Laundry and Textiles in the United States: Review and Commentary on Contemporary Infection Prevention Issues.

    PubMed

    Sehulster, Lynne M

    2015-09-01

    Healthcare professionals have questions about the infection prevention effectiveness of contemporary laundry processes for healthcare textiles (HCTs). Current industrial laundry processes achieve microbial reductions via physical, chemical, and thermal actions, all of which result in producing hygienically clean HCTs. European researchers have demonstrated that oxidative laundry additives have sufficient potency to meet US Environmental Protection Agency benchmarks for sanitizers and disinfectants. Outbreaks of infectious diseases associated with laundered HCTs are extremely rare; only 12 such outbreaks have been reported worldwide in the past 43 years. Root cause analyses have identified inadvertent exposure of clean HCTs to environmental contamination (including but not limited to exposure to dust in storage areas) or a process failure during laundering. To date, patient-to-patient transmission of infection has not been associated with hygienically clean HCTs laundered in accordance with industry process standards. Occupationally acquired infection involved mishandling of soiled HCTs and failure to use personal protective equipment properly. Laboratory studies of antimicrobial treatments for HCTs demonstrate a wide range of activity from 1 to 7 log10 reduction of pathogens under various experimental conditions. Clinical studies are needed to evaluate potential use of these treatments for infection prevention. Microbiological testing of clean HCTs for certification purposes is now available in the United States. Key features (eg, microbial sampling strategy, numbers of textiles sampled) and justification of the testing are discussed. PMID:26082994

  3. Psychosocial oncofertility issues faced by adolescents and young adults over their lifetime: a review of the research.

    PubMed

    Crawshaw, Marilyn

    2013-03-01

    This review considers psychosocial oncofertility research relevant to adolescents and young adults over their lifetime. There is growing awareness of the fertility preservation needs of younger males including lowering practical barriers and attending to emotional impact. Despite decisional challenges facing females--the experimental nature of procedures, time involved and potential involvement of partners/donors (for embryo cryopreservation)--findings suggest they too benefit from fertility information at diagnosis and access to fertility specialists. Studies consistently report that fertility concerns affect well-being, relationships and life planning. Both genders thus want fertility issues to be raised proactively by professionals in the years following diagnosis: to help them make informed decisions at a time relevant to them, develop coping strategies for current and future related areas and to be referred to specialist and/or therapeutic help if needed. Little is known about why cancer survivors are less likely to marry or have children, or about their parenthood experiences. PMID:23009083

  4. Emerging issue of e-waste in Pakistan: A review of status, research needs and data gaps.

    PubMed

    Iqbal, Mehreen; Breivik, Knut; Syed, Jabir Hussain; Malik, Riffat Naseem; Li, Jun; Zhang, Gan; Jones, Kevin C

    2015-12-01

    This review article focuses on the current situation of e-waste in Pakistan with the emphasis on defining the major e-waste recycling sites, current and future domestic generation of e-waste, hidden flows or import of e-waste and discusses various challenges for e-waste management. Needed policy interventions and possible measures to be taken at governmental level are discussed to avoid the increasing problem of e-waste in the country. Our findings highlight that there is still a general lack of reliable data, inventories and research studies addressing e-waste related issues in the context of environmental and human health in Pakistan. There is therefore a critical need to improve the current knowledge base, which should build upon the research experience from other countries which have experienced similar situations in the past. Further research into these issues in Pakistan is considered vital to help inform future policies/control strategies as already successfully implemented in other countries. PMID:26433180

  5. A Comparison of Anonymous versus Identifiable e-Peer Review on College Student Writing Performance and the Extent of Critical Feedback

    ERIC Educational Resources Information Center

    Lu, Ruiling; Bol, Linda

    2007-01-01

    Peer review has become commonplace in composition courses and is increasingly employed in the context of telecommunication technology. The purpose of this experiment was to compare the effects of anonymous and identifiable electronic peer (e-peer) review on college student writing performance and the extent of critical peer feedback. Participants…

  6. Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis

    PubMed Central

    Nebenzahl-Guimaraes, Hanna; Jacobson, Karen R.; Farhat, Maha R.; Murray, Megan B.

    2014-01-01

    Background Improving our understanding of the relationship between the genotype and the drug resistance phenotype of Mycobacterium tuberculosis will aid the development of more accurate molecular diagnostics for drug-resistant tuberculosis. Studies that use direct genetic manipulation to identify the mutations that cause M. tuberculosis drug resistance are superior to associational studies in elucidating an individual mutation's contribution to the drug resistance phenotype. Methods We systematically reviewed the literature for publications reporting allelic exchange experiments in any of the resistance-associated M. tuberculosis genes. We included studies that introduced single point mutations using specialized linkage transduction or site-directed/in vitro mutagenesis and documented a change in the resistance phenotype. Results We summarize evidence supporting the causal relationship of 54 different mutations in eight genes (katG, inhA, kasA, embB, embC, rpoB, gyrA and gyrB) and one intergenic region (furA-katG) with resistance to isoniazid, the rifamycins, ethambutol and fluoroquinolones. We observed a significant role for the strain genomic background in modulating the resistance phenotype of 21 of these mutations and found examples of where the same drug resistance mutations caused varying levels of resistance to different members of the same drug class. Conclusions This systematic review highlights those mutations that have been shown to causally change phenotypic resistance in M. tuberculosis and brings attention to a notable lack of allelic exchange data for several of the genes known to be associated with drug resistance. PMID:24055765

  7. Review of Department Identified Contracts and Grants for Public Relations Services. Final Inspection Report. ED-OIG/I13-F0012

    ERIC Educational Resources Information Center

    US Department of Education, 2005

    2005-01-01

    The objective of this inspection was to review the materials produced under 20 contracts and 15 grants issued by the Department of Education (Department) to determine whether any of the contracts and grants resulted in covert propaganda. It has been concluded that none of the grants resulted in covert propaganda under the existing guidance of the…

  8. Development and application of the Safe Performance Index as a risk-based methodology for identifying major hazard-related safety issues in underground coal mines

    NASA Astrophysics Data System (ADS)

    Kinilakodi, Harisha

    The underground coal mining industry has been under constant watch due to the high risk involved in its activities, and scrutiny increased because of the disasters that occurred in 2006-07. In the aftermath of the incidents, the U.S. Congress passed the Mine Improvement and New Emergency Response Act of 2006 (MINER Act), which strengthened the existing regulations and mandated new laws to address the various issues related to a safe working environment in the mines. Risk analysis in any form should be done on a regular basis to tackle the possibility of unwanted major hazard-related events such as explosions, outbursts, airbursts, inundations, spontaneous combustion, and roof fall instabilities. One of the responses by the Mine Safety and Health Administration (MSHA) in 2007 involved a new pattern of violations (POV) process to target mines with a poor safety performance, specifically to improve their safety. However, the 2010 disaster (worst in 40 years) gave an impression that the collective effort of the industry, federal/state agencies, and researchers to achieve the goal of zero fatalities and serious injuries has gone awry. The Safe Performance Index (SPI) methodology developed in this research is a straight-forward, effective, transparent, and reproducible approach that can help in identifying and addressing some of the existing issues while targeting (poor safety performance) mines which need help. It combines three injury and three citation measures that are scaled to have an equal mean (5.0) in a balanced way with proportionate weighting factors (0.05, 0.15, 0.30) and overall normalizing factor (15) into a mine safety performance evaluation tool. It can be used to assess the relative safety-related risk of mines, including by mine-size category. Using 2008 and 2009 data, comparisons were made of SPI-associated, normalized safety performance measures across mine-size categories, with emphasis on small-mine safety performance as compared to large- and

  9. The Psychology of Confessions: A Review of the Literature and Issues.

    PubMed

    Kassin, Saul M; Gudjonsson, Gisli H

    2004-11-01

    Recently, in a number of high-profile cases, defendants who were prosecuted, convicted, and sentenced on the basis of false confessions have been exonerated through DNA evidence. As a historical matter, confession has played a prominent role in religion, in psychotherapy, and in criminal law-where it is a prosecutor's most potent weapon. In recent years, psychologists from the clinical, personality, developmental, cognitive, and social areas have brought their theories and research methods to bear on an analysis of confession evidence, how it is obtained, and what impact it has on judges, juries, and other people. Drawing on individual case studies, archival reports, correlational studies, and laboratory and field experiments, this monograph scrutinizes a sequence of events during which confessions may be obtained from criminal suspects and used as evidence. First, we examine the preinterrogation interview, a process by which police target potential suspects for interrogation by making demeanor-based judgments of whether they are being truthful. Consistent with the literature showing that people are poor lie detectors, research suggests that trained and experienced police investigators are prone to see deception at this stage and to make false-positive errors, disbelieving people who are innocent, with a great deal of confidence. Second, we examine the Miranda warning and waiver, a process by which police apprise suspects of their constitutional rights to silence and to counsel. This important procedural safeguard is in place to protect the accused, but researchers have identified reasons why it may have little impact. One reason is that some suspects do not have the capacity to understand and apply these rights. Another is that police have developed methods of obtaining waivers. Indeed, innocent people in particular tend to waive their rights, naively believing that they have nothing to fear or hide and that their innocence will set them free. Third, we examine

  10. Identifying Computer-Supported Collaborative Learning (CSCL) Research in Selected Journals Published from 2003 to 2012: A Content Analysis of Research Topics and Issues

    ERIC Educational Resources Information Center

    Zheng, Lanqin; Huang, Ronghuai; Yu, Junhui

    2014-01-01

    This study aims to identity the emerging research trends in the field of computed-supported collaborative learning (CSCL) so as to provide insights for researchers and educators into research topics and issues for further exploration. This paper analyzed the research topics, methods and technology adoption of CSCL from 2003 to 2012. A total of 706…

  11. After-Action Reports: Capturing Lessons Learned and Identifying Areas for Improvement. Lessons Learned from School Crises and Emergencies. Volume 2, Issue 1, 2007

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    "Lessons Learned" is a series of publications that are a brief recounting of actual school emergencies and crises. This issue of "Lessons Learned" addresses after-action reports, which are an integral part of the emergency preparedness planning continuum and support effective crisis response. After-action reports have a threefold purpose. They…

  12. Identifying Issues and Concerns with the Use of Interval-Based Systems in Single Case Research Using a Pilot Simulation Study

    ERIC Educational Resources Information Center

    Ledford, Jennifer R.; Ayres, Kevin M.; Lane, Justin D.; Lam, Man Fung

    2015-01-01

    Momentary time sampling (MTS), whole interval recording (WIR), and partial interval recording (PIR) are commonly used in applied research. We discuss potential difficulties with analyzing data when these systems are used and present results from a pilot simulation study designed to determine the extent to which these issues are likely to be…

  13. The Sociological Study of Suicide: Methodological Issues.

    ERIC Educational Resources Information Center

    Stack, Steven

    1987-01-01

    Reviews methodological issues in the sociological study of suicide, distinguishing between micro and macro approaches. Focusing on critical assessment of macro-level methodology, identifies three recurrent problems: (1) measurement issues on four key variables; (2) problems studying effect of mass media suicide stories; and (3) reasons to adopt…

  14. Emerging Environmental Issues.

    NASA Astrophysics Data System (ADS)

    Munn, Ted; Timmerman, Peter; Whyte, Anne

    2000-07-01

    Emerging environmental issues are issues that may someday be of concern but that have not yet been generally recognized. A review of such issues that have occurred over the last 50 years reveals that many of them have erupted rather suddenly (e.g., stratospheric ozone depletion, acid rain). However, some issues were recognized long ago by the scientific community (e.g., land degradation, overconsumption of freshwater), but for economic or other reasons governments have refused to act. The authors of this study were commissioned by the United Nations Environment Program and the Scientific Committee on Problems of the Environment to carry out a global survey of emerging environmental issues, using the responses received to questionnaires that were sent to scientists, managers, and policy makers around the world. It had been hoped that a short list of priority issues could be identified but the number of issues was very long. However, the issues could be divided into four major classes: 1) Transformations of old issues; continually evolving, and in most cases broadening, in response to increasing scientific and technological knowledge and to changing socioeconomic, cultural, and environmental conditions. 2) Policy issues, the long-term environmental consequences of which may already be of concern. 3) Accidents waiting to happen, for example, chemical time bombs. 4) Surprises in the nonlinear responses of ecosystems to new and different stresses, as well as in the nature of socioeconomic drivers of environmental change. In a subsequent study, the authors applied the lessons learned in the global study to an examination of emerging environmental issues in the province of Ontario, Canada.

  15. Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues.

    PubMed

    Tzschentke, T M

    1998-12-01

    This review gives an overview of recent findings and developments in research on brain mechanisms of reward and reinforcement from studies using the place preference conditioning paradigm, with emphasis on those studies that have been published within the last decade. Methodological issues of the paradigm (such as design of the conditioning apparatus, biased vs unbiased conditioning, state dependency effects) are discussed. Results from studies using systemic and local (intracranial) drug administration, natural reinforcers, and non-drug treatments and from studies examining the effects of lesions are presented. Papers reporting on conditioned place aversion (CPA) experiments are also included. A special emphasis is put on the issue of tolerance and sensitization to the rewarding properties of drugs. Transmitter systems that have been investigated with respect to their involvement in brain reward mechanisms include dopamine, opioids, acetylcholine, GABA, serotonin, glutamate, substance P, and cholecystokinin, the motivational significance of which has been examined either directly, by using respective agonist or antagonist drugs, or indirectly, by studying the effects of these drugs on the reward induced by other drugs. For a number of these transmitters, detailed studies have been conducted to delineate the receptor subtype(s) responsible for the mediation of the observed drug effects, particularly in the case of dopamine, the opioids, serotonin and glutamate. Brain sites that have been implicated in the mediation of drug-induced place conditioning include the 'traditional' brain reward sites, ventral tegmental area and nucleus accumbens, but the medial prefrontal cortex, ventral pallidum, amygdala and the pedunculopontine tegmental nucleus have also been shown to play important roles in the mediation of place conditioning induced by drugs or natural reinforcers. Thus, although the paradigm has also been criticized because of some inherent methodological problems

  16. Issues associated with manipulator-based waste retrieval from Hanford underground storage tanks with a preliminary review of commercial concepts

    SciTech Connect

    Berglin, E.J.

    1996-09-17

    Westinghouse Hanford Company (WHC) is exploring commercial methods for retrieving waste from the underground storage tanks at the Hanford site in south central Washington state. WHC needs data on commercial retrieval systems equipment in order to make programmatic decisions for waste retrieval. Full system testing of retrieval processes is to be demonstrated in phases through September 1997 in support of programs aimed to Acquire Commercial Technology for Retrieval (ACTR) and at the Hanford Tanks Initiative (HTI). One of the important parts of the integrated testing will be the deployment of retrieval tools using manipulator-based systems. WHC requires an assessment of a number of commercial deployment systems that have been identified by the ACTR program as good candidates to be included in an integrated testing effort. Included in this assessment should be an independent evaluation of manipulator tests performed to date, so that WHC can construct an integrated test based on these systems. The objectives of this document are to provide a description of the need, requirements, and constraints for a manipulator-based retrieval system; to evaluate manipulator-based concepts and testing performed to date by a number of commercial organizations; and to identify issues to be resolved through testing and/or analysis for each concept.

  17. Informed-Consent Issues with Adolescent Health Behavior Research

    ERIC Educational Resources Information Center

    Olds, R. Scott

    2003-01-01

    Objective: To identify the informed-consent issues when conducting adolescent health behavior research. Methods: A literature review was conducted across diverse academic fields about the informed-consent issues that were relevant to adolescent health behavior research. Results: Issues included defining consent, assent and permission, minimal…

  18. Historical review of clinical vaccine studies at Oswaldo Cruz Institute and Oswaldo Cruz Foundation - technological development issues

    PubMed Central

    Martins, Reinaldo de Menezes; Possas, Cristina de Albuquerque; Homma, Akira

    2015-01-01

    This paper presents, from the perspective of technological development and production, the results of an investigation examining 61 clinical studies with vaccines conducted in Brazil between 1938-2013, with the participation of the Oswaldo Cruz Institute (IOC) and the Oswaldo Cruz Foundation (Fiocruz). These studies have been identified and reviewed according to criteria, such as the kind of vaccine (viral, bacterial, parasitic), their rationale, design and methodological strategies. The results indicate that IOC and Fiocruz have accumulated along this time significant knowledge and experience for the performance of studies in all clinical phases and are prepared for the development of new vaccines products and processes. We recommend national policy strategies to overcome existing regulatory and financing constraints. PMID:25742271

  19. Review of recent studies and issues regarding the P300-based complex trial protocol for detection of concealed information.

    PubMed

    Rosenfeld, J Peter; Hu, Xiaoqing; Labkovsky, Elena; Meixner, John; Winograd, Michael R

    2013-11-01

    In this review, the evolution of new P300-based protocols for detection of concealed information is summarized. The P300-based complex trial protocol (CTP) is described as one such countermeasure (CM)-resistant protocol. Recent lapses in diagnostic accuracy (from 90% to 75%) with CTPs applied to mock crime protocols are summarized, as well as recent enhancements to the CTP which have restored accuracy. These enhancements include 1) use of performance feedback during testing, 2) use of other ERP components such as N200 in diagnosis, 3) use of auxiliary tests, including the autobiographical implicit association test, as leading to restored diagnostic accuracy, and 4) a study of the mechanisms underlying CMs. A novel, doubly efficient version of the CTP involving presentation of two probes in one trial is described as a new way to improve accuracy to levels above 90% in mock crime situations. Finally, a thorough analysis of the legal issues surrounding use of the CTP in U.S. is given. PMID:24012907

  20. Detecting and overcoming systematic bias in high-throughput screening technologies: a comprehensive review of practical issues and methodological solutions.

    PubMed

    Caraus, Iurie; Alsuwailem, Abdulaziz A; Nadon, Robert; Makarenkov, Vladimir

    2015-11-01

    Significant efforts have been made recently to improve data throughput and data quality in screening technologies related to drug design. The modern pharmaceutical industry relies heavily on high-throughput screening (HTS) and high-content screening (HCS) technologies, which include small molecule, complementary DNA (cDNA) and RNA interference (RNAi) types of screening. Data generated by these screening technologies are subject to several environmental and procedural systematic biases, which introduce errors into the hit identification process. We first review systematic biases typical of HTS and HCS screens. We highlight that study design issues and the way in which data are generated are crucial for providing unbiased screening results. Considering various data sets, including the publicly available ChemBank data, we assess the rates of systematic bias in experimental HTS by using plate-specific and assay-specific error detection tests. We describe main data normalization and correction techniques and introduce a general data preprocessing protocol. This protocol can be recommended for academic and industrial researchers involved in the analysis of current or next-generation HTS data. PMID:25750417

  1. Identifying and Supporting English Learner Students with Learning Disabilities: Key Issues in the Literature and State Practice. REL 2015-086

    ERIC Educational Resources Information Center

    Burr, Elizabeth; Haas, Eric; Ferriere, Karen

    2015-01-01

    While the literature on learning disabilities and on second-language acquisition is relatively extensive within the field of education, less is known about the specific characteristics and representation of English learner students with learning disabilities. Because there are no definitive resources and processes for identifying and determining…

  2. How Eight State Education Agencies in the Northeast and Islands Region Identify and Support Low-Performing Schools and Districts. Issues & Answers. REL 2009-No. 068

    ERIC Educational Resources Information Center

    Hergert, Leslie F.; Gleason, Sonia Caus; Urbano, Carole

    2009-01-01

    This report describes and analyzes how eight state education agencies in the Northeast and Islands Region (Connecticut, Maine, Massachusetts, New Hampshire, New York, Puerto Rico, Rhode Island, and Vermont) identify and support low-performing schools and districts under the No Child Left Behind Act of 2001 (NCLB). Data collection for the report…

  3. How Eight State Education Agencies in the Northeast and Islands Region Identify and Support Low-Performing Schools and Districts. Summary. Issues & Answers. REL 2009-No. 068

    ERIC Educational Resources Information Center

    Hergert, Leslie F.; Gleason, Sonia Caus; Urbano, Carole

    2009-01-01

    This document presents a summary of the report, "How Eight State Education Agencies in the Northeast and Islands Region Identify and Support Low-Performing Schools and Districts." This larger report describes and analyzes how eight state education agencies in the Northeast and Islands Region (Connecticut, Maine, Massachusetts, New Hampshire, New…

  4. Molten Salts for High Temperature Reactors: University of Wisconsin Molten Salt Corrosion and Flow Loop Experiments -- Issues Identified and Path Forward

    SciTech Connect

    Piyush Sabharwall; Matt Ebner; Manohar Sohal; Phil Sharpe; Thermal Hydraulics Group

    2010-03-01

    Considerable amount of work is going on regarding the development of high temperature liquid salts technology to meet future process needs of Next Generation Nuclear Plant. This report identifies the important characteristics and concerns of high temperature molten salts (with lesson learned at University of Wisconsin-Madison, Molten Salt Program) and provides some possible recommendation for future work

  5. Identifying Children and Adolescents with Depression: Review of the Stimulus Drawing Task and Draw a Story Research

    ERIC Educational Resources Information Center

    Silver, Rawley

    2009-01-01

    This paper reviews a body of research on the author's Silver Drawing Test (SDT) and Draw A Story (DAS) art-based assessments, which span 40 years of development. The original impetus for the assessment is described and studies are reviewed that examined relationships between depression, abuse, and aggression; cognitive skills; interrater and…

  6. Utility interconnection issues for wind power generation

    NASA Technical Reports Server (NTRS)

    Herrera, J. I.; Lawler, J. S.; Reddoch, T. W.; Sullivan, R. L.

    1986-01-01

    This document organizes the total range of utility related issues, reviews wind turbine control and dynamic characteristics, identifies the interaction of wind turbines to electric utility systems, and identifies areas for future research. The material is organized at three levels: the wind turbine, its controls and characteristics; connection strategies as dispersed or WPSs; and the composite issue of planning and operating the electric power system with wind generated electricity.

  7. The monitoring, evaluation, reporting, and verification of climate change mitigation projects: Discussion of issues and methodologies and review of existing protocols and guidelines

    SciTech Connect

    Vine, E.; Sathaye, J.

    1997-12-01

    Because of concerns with the growing threat of global climate change from increasing emissions of greenhouse gases, the US and other countries are implementing, by themselves or in cooperation with one or more other nations (i.e., joint implementation), climate change mitigation projects. These projects will reduce greenhouse gas (GHG) emissions or sequester carbon, and will also result in non-GHG impacts (i.e., environmental, economic, and social impacts). Monitoring, evaluating, reporting, and verifying (MERV) guidelines are needed for these projects in order to accurately determine their net GHG, and other, benefits. Implementation of MERV guidelines is also intended to: (1) increase the reliability of data for estimating GHG benefits; (2) provide real-time data so that mid-course corrections can be made; (3) introduce consistency and transparency across project types and reporters; and (4) enhance the credibility of the projects with stakeholders. In this paper, the authors review the issues and methodologies involved in MERV activities. In addition, they review protocols and guidelines that have been developed for MERV of GHG emissions in the energy and non-energy sectors by governments, nongovernmental organizations, and international agencies. They comment on their relevance and completeness, and identify several topics that future protocols and guidelines need to address, such as (1) establishing a credible baseline; (2) accounting for impacts outside project boundaries through leakage; (3) net GHG reductions and other impacts; (4) precision of measurement; (5) MERV frequency; (6) persistence (sustainability) of savings, emissions reduction, and carbon sequestration; (7) reporting by multiple project participants; (8) verification of GHG reduction credits; (9) uncertainty and risk; (10) institutional capacity in conducting MERV; and (11) the cost of MERV.

  8. Analysis of warning letters issued by the US Food and Drug Administration to clinical investigators, institutional review boards and sponsors: a retrospective study.

    PubMed

    Shetty, Yashashri C; Saiyed, Aafreen A

    2015-05-01

    The US Food and Drug Administration (FDA) issues warning letters to all research stakeholders if unacceptable deficiencies are found during site visits. Warning letters issued by the FDA between January 2011 and December 2012 to clinical investigators and institutional review boards (IRBs) were reviewed for various violation themes and compared to similar studies in the past. Warning letters issued to sponsors between January 2005 and December 2012 were analysed for the first time for a specific set of violations using descriptive statistics. Failure to protect subject safety and to report adverse events to IRBs was found to be significant compared to prior studies for clinical investigators, while failure to follow standard operating procedures and maintain documentation was noted as significant in warning letters to IRBs. Failure to maintain minutes of meeting and to follow written procedures for continuing review were new substantial violations in warning letters issued to IRBs. Forty-six warning letters were issued to sponsors, the most common violations being failure to follow a monitoring schedule (58.69%), failure to obtain investigator agreement (34.78%), failure to secure investigators' compliance (30.43%), and failure to maintain data records and ship documents to investigators (30.43%). Appropriate methods for handling clinical trial procedural violations should be developed and implemented worldwide. PMID:24965716

  9. A Literary Review of One Versus Two Factor Theories of Learning as the Issue Relates to Operant Conditioning of the Autonomic Nervous System.

    ERIC Educational Resources Information Center

    Christ, Susann

    This paper reviews several issues regarding one- versus two-factor theories of learning. First, the traditional distinctions between classical and operant conditioning are presented. This includes both theoretical and experimental contrasts. Second, empirical evidence in support for a one-factor theory is examined. Numerous research studies…

  10. Academic Accommodations for Postsecondary Students with Mental Health Disabilities in Ontario, Canada: A Review of the Literature and Reflections on Emerging Issues

    ERIC Educational Resources Information Center

    Condra, Mike; Dineen, Mira; Gills, Helen; Jack-Davies, Anita; Condra, Eleanor

    2015-01-01

    An increasing number of students with mental health disabilities (MHDs) are enrolling at Canadian colleges and universities. This review examines the challenges and complexities of meeting the unique needs of these students at Ontario's postsecondary institutions, with a specific focus on the issue of academic accommodations. These complexities…

  11. Controlling the Costs of Education in Eastern Africa: A Review of Data, Issues, and Policies. World Bank Staff Working Papers No. 702.

    ERIC Educational Resources Information Center

    Wolff, Laurence

    Data and issues on costs of primary, secondary, and higher education in Eastern Africa are presented. Practical recommendations for controlling or reducing costs while paying attention to effects on quality and equity are made. For each level of education the report reviews student-teacher ratios, teacher salaries, non-teaching costs, and…

  12. Physical activity promotion in Latin American populations: a systematic review on issues of internal and external validity

    PubMed Central

    2014-01-01

    The purpose of this review was to determine the degree to which physical activity interventions for Latin American populations reported on internal and external validity factors using the RE-AIM framework (reach & representativeness, effectiveness, adoption, implementation, maintenance). We systematically identified English (PubMed; EbscoHost) and Spanish (SCIELO; Biblioteca Virtual en Salud) language studies published between 2001 and 2012 that tested physical activity, exercise, or fitness promotion interventions in Latin American populations. Cross-sectional/descriptive studies, conducted in Brazil or Spain, published in Portuguese, not including a physical activity/fitness/exercise outcome, and with one time point assessment were excluded. We reviewed 192 abstracts and identified 46 studies that met the eligibility criteria (34 in English, 12 in Spanish). A validated 21-item RE-AIM abstraction tool was used to determine the quality of reporting across studies (0-7 = low, 8-14 = moderate, and 15-21 = high). The number of indicators reported ranged from 3–14 (mean = 8.1 ± 2.6), with the majority of studies falling in the moderate quality reporting category. English and Spanish language articles did not differ on the number of indicators reported (8.1 vs. 8.3, respectively). However, Spanish articles reported more across reach indicators (62% vs. 43% of indicators), while English articles reported more across effectiveness indicators (69% vs 62%). Across RE-AIM dimensions, indicators for reach (48%), efficacy/effectiveness (67%), and implementation (41%) were reported more often than indicators of adoption (25%) and maintenance (10%). Few studies reported on the representativeness of participants, staff that delivered interventions, or the settings where interventions were adopted. Only 13% of the studies reported on quality of life and/or potential negative outcomes, 20% reported on intervention fidelity, and 11% on cost of implementation

  13. Lessons from a recent adoption study to identify some of the service needs of, and issues for, donor offspring wanting to know about their donors.

    PubMed

    Crawshaw, Marilyn

    2002-02-01

    This paper draws on some of the major findings of a recent large-scale study of over 400 adult adopted people, who either searched for origins information or were sought out by birth relatives, to identify the potential profile of donor offspring seeking origins information. It is predicted that more women than men will search, that people who search will be in their twenties or older, and that the age at which searching begins may be delayed by the effects of the social stigma attached to gamete donation and by the greater likelihood of accidental disclosure in adulthood resulting from the higher incidence of secrecy about donor assisted conception. Two of the single triggers for adopted people to begin searching (as opposed to multiple triggers) - becoming a parent and the death of adoptive parents - may also be among the triggers for donor offspring to begin searching. The search may be complicated further when undertaken after accidental disclosure. Finally, it is argued that some donor offspring will experience a normative urge for identity completion and seeking relationships similar to that experienced by adopted people. This urge may stem from the fact that some donor offspring attach an identity to their donor that extends beyond needing factual details about their physical characteristics (though not necessarily a desire to establish a relationship). Some donor offspring are likely to encounter a desire for face-to-face contact, regardless of whether a face-to-face meeting was the original intention. The need for services to help donor offspring, donors, family members and others affected by the situation is identified. PMID:11897902

  14. Radioactive waste isolation in salt: Peer review of the Office of Nuclear Waste Isolation's draft report on an issues hierarchy and data needs for site characterization

    SciTech Connect

    Harrison, W.; Fenster, D.F.; Ditmars, J.D.; Paddock, R.A.; Rote, D.M.; Hambley, D.F.; Seitz, M.G.; Hull, A.B.

    1986-12-01

    At the request of the Salt Repository Project (SRPO), Argonne National Laboratory conducted an independent peer review of a report by the Battelle Office of Nuclear Waste Isolation entitled ''Salt Repository Project Issues Hierarchy and Data Needs for Site Characterization (Draft).'' This report provided a logical structure for evaluating the outstanding questions (issues) related to selection and licensing of a site as a high-level waste repository. It also provided a first estimate of the information and data necessary to answer or resolve those questions. As such, this report is the first step in developing a strategy for site characterization. Microfiche copies of ''Draft Issues Hierarchy, Resolution Strategy, and Information Needs for Site Characterization and Environmental/Socioeconomic Evaluation - July, 1986'' and ''Issues Hierarchy and Data Needs for Site Characterization - February, 1985'' are included in the back pocket of this report.

  15. On estimation and identifiability issues of sex-linked inheritance with a case study of pigmentation in Swiss barn owl (Tyto alba).

    PubMed

    Larsen, Camilla T; Holand, Anna M; Jensen, Henrik; Steinsland, Ingelin; Roulin, Alexandre

    2014-05-01

    Genetic evaluation using animal models or pedigree-based models generally assume only autosomal inheritance. Bayesian animal models provide a flexible framework for genetic evaluation, and we show how the model readily can accommodate situations where the trait of interest is influenced by both autosomal and sex-linked inheritance. This allows for simultaneous calculation of autosomal and sex-chromosomal additive genetic effects. Inferences were performed using integrated nested Laplace approximations (INLA), a nonsampling-based Bayesian inference methodology. We provide a detailed description of how to calculate the inverse of the X- or Z-chromosomal additive genetic relationship matrix, needed for inference. The case study of eumelanic spot diameter in a Swiss barn owl (Tyto alba) population shows that this trait is substantially influenced by variation in genes on the Z-chromosome ([Formula: see text] and [Formula: see text]). Further, a simulation study for this study system shows that the animal model accounting for both autosomal and sex-chromosome-linked inheritance is identifiable, that is, the two effects can be distinguished, and provides accurate inference on the variance components. PMID:24967075

  16. On estimation and identifiability issues of sex-linked inheritance with a case study of pigmentation in Swiss barn owl (Tyto alba)

    PubMed Central

    Larsen, Camilla T; Holand, Anna M; Jensen, Henrik; Steinsland, Ingelin; Roulin, Alexandre

    2014-01-01

    Genetic evaluation using animal models or pedigree-based models generally assume only autosomal inheritance. Bayesian animal models provide a flexible framework for genetic evaluation, and we show how the model readily can accommodate situations where the trait of interest is influenced by both autosomal and sex-linked inheritance. This allows for simultaneous calculation of autosomal and sex-chromosomal additive genetic effects. Inferences were performed using integrated nested Laplace approximations (INLA), a nonsampling-based Bayesian inference methodology. We provide a detailed description of how to calculate the inverse of the X- or Z-chromosomal additive genetic relationship matrix, needed for inference. The case study of eumelanic spot diameter in a Swiss barn owl (Tyto alba) population shows that this trait is substantially influenced by variation in genes on the Z-chromosome ( and ). Further, a simulation study for this study system shows that the animal model accounting for both autosomal and sex-chromosome-linked inheritance is identifiable, that is, the two effects can be distinguished, and provides accurate inference on the variance components. PMID:24967075

  17. Use of the EFPA Test Review Model by the UK and Issues Relating to the Internationalization of Test Standards

    ERIC Educational Resources Information Center

    Lindley, Patricia A.; Bartram, Dave

    2012-01-01

    In this article, we present the background to the development of test reviewing by the British Psychological Society (BPS) in the United Kingdom. We also describe the role played by the BPS in the development of the EFPA test review model and its adaptation for use in test reviewing in the United Kingdom. We conclude with a discussion of lessons…

  18. Undergraduate Latina/o Students: A Systematic Review of Research Identifying Factors Contributing to Academic Success Outcomes

    ERIC Educational Resources Information Center

    Crisp, Gloria; Taggart, Amanda; Nora, Amaury

    2015-01-01

    A systematic review was conducted to produce an up-to-date and comprehensive summary of qualitative and quantitative evidence specific to the factors related to undergraduate Latina/o student academic success outcomes during college. The purpose of the study was to make sense of and provide critique to this rapidly growing body of research, as…

  19. Use of the MMPI-I in Identifying Personality Characteristics of Anorexia Nervosa, Restrictor Subtype: A Review of the Literature.

    ERIC Educational Resources Information Center

    Regardie, Cynthia Ramos

    In recent decades, the incidence of eating disorders has sharply increased. This paper reviews literature published between 1969 through 1992 which addresses personality characteristics of individuals with anorexia nervosa, restrictor subtype, utilizing the Minnesota Multiphasic Personality Inventory (MMPI-I). The current literature and research…

  20. A Review of Declared Factors Identified by Parents of Children with Autism Spectrum Disorders (ASD) in Making Intervention Decisions

    ERIC Educational Resources Information Center

    Carlon, Sarah; Carter, Mark; Stephenson, Jennifer

    2013-01-01

    The range of interventions available for children with autism spectrum disorders (ASD) has increased in recent years. This has led to an interest in the decision-making process related to intervention choices for parents of children with ASD. The present paper reviewed 16 studies examining the factors declared by parents as affecting their…

  1. 10 CFR 2.603 - Acceptance and docketing of application for early review of site suitability issues in a...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... of site suitability issues in a construction permit proceeding. 2.603 Section 2.603 Energy NUCLEAR... Partial Decisions on Site Suitability Issues in Connection With an Application for a Construction Permit... Authorizations Early Partial Decisions on Site Suitability-Construction Permit § 2.603 Acceptance and...

  2. 10 CFR 2.621 - Acceptance and docketing of application for early review of site suitability issues in a combined...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Authorizations Early Partial Decisions on Site Suitability-Combined License Under 10 Cfr Part 52 § 2.621... of site suitability issues in a combined license proceeding. 2.621 Section 2.621 Energy NUCLEAR... Partial Decisions on Site Suitability Issues in Connection With an Application for a Construction...

  3. 10 CFR 2.603 - Acceptance and docketing of application for early review of site suitability issues in a...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... of site suitability issues in a construction permit proceeding. 2.603 Section 2.603 Energy NUCLEAR... Procedures Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an Application... Issuance of Limited Work Authorizations Early Partial Decisions on Site Suitability-Construction Permit §...

  4. 10 CFR 2.603 - Acceptance and docketing of application for early review of site suitability issues in a...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... of site suitability issues in a construction permit proceeding. 2.603 Section 2.603 Energy NUCLEAR... Partial Decisions on Site Suitability Issues in Connection With an Application for a Construction Permit... Authorizations Early Partial Decisions on Site Suitability-Construction Permit § 2.603 Acceptance and...

  5. 10 CFR 2.621 - Acceptance and docketing of application for early review of site suitability issues in a combined...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Authorizations Early Partial Decisions on Site Suitability-Combined License Under 10 Cfr Part 52 § 2.621... of site suitability issues in a combined license proceeding. 2.621 Section 2.621 Energy NUCLEAR... Partial Decisions on Site Suitability Issues in Connection With an Application for a Construction...

  6. A review of foundational methods for checking the structural identifiability of models: Results for rainfall-runoff

    NASA Astrophysics Data System (ADS)

    Shin, Mun-Ju; Guillaume, Joseph H. A.; Croke, Barry F. W.; Jakeman, Anthony J.

    2015-01-01

    Checking for model identifiability has several advantages as outlined in the paper. We illustrate the use of several screening methods for assessing structural identifiability that should serve as a valuable precursor to model redesign and more sophisticated uncertainty analyses. These are: global evolutionary optimisation algorithms (EAs) that are being used increasingly to estimate parameters of models because of their flexibility; one and two-dimensional discrete model response plots with the latter showing trajectories of convergence/non-convergence; quadratic response surface approximations; and sensitivity analysis of combinations of parameters using Polynomial Chaos Expansion model emulation. Each method has a role to play in understanding the nature of non-identifiability. We illustrate the utility and complementary value of these methods for conceptual rainfall-runoff processes with real and 'exact' daily flow data, hydrological models of increasing complexity, and different objective functions. We conclude that errors in data are not primarily the cause of the parameter identification problem and objective function selection gives only a partial solution. Model structure reveals itself to be a major problem for the two more complex models examined, as characterised by the dotty/1D, 2D projection and eigen plots. The Polynomial Chaos Expansion method helps reveal which interactions between parameters could affect the model identifiability. Structural non-identifiability is seen to pervade even at modest levels of model complexity.

  7. Issues and recommendations related to replacement of CFC-114 at the uranium enrichment gaseous diffusion plant. Task title: Chlorofluorocarbon (CFC) Program Review, Final report, August 1, 1991--October 1, 1992

    SciTech Connect

    Anderson, B.L.; Banaghan, E.

    1993-03-31

    The operating uranium enrichment gaseous diffusion plants (GDPs) in Portsmouth, Ohio and Paducah, Kentucky, which are operated for the United States Department for Energy by Martin Marietta Energy Systems (MMES), currently use a chlorofluorocarbon (CFC-114) as the primary process stream coolant. Due to recent legislation embodied in the Clean Air Act, the production of this and other related chlorofluorocarbons (CFCS) are to be phased out with no production occurring after 1995. Since the plants lose approximately 500,000 pounds per year of this process stream coolant through various leaks, the GDPs are faced with the challenge of identifying a replacement coolant that will allow continued operation of the plants. MMES formed the CFC Task Team to identify and solve the various problems associated with identifying and implementing a replacement coolant. This report includes a review of the work performed by the CFC Task Team, and recommendations that were formulated based on this review and upon original work. The topics covered include; identifying a replacement coolant, coolant leak detection and repair efforts, coolant safety concerns, coolant level sensors, regulatory issues, and an analytical decision analysis.

  8. "RiDE" Themed Issue--On Disability: Creative Tensions in Applied Theatre--An Extended Review

    ERIC Educational Resources Information Center

    Roulstone, Alan

    2010-01-01

    The year 2009 witnessed the publication of a themed edition of "Research in Drama Education" on disability (vol. 14, no. 1). This is a "first", and the author comes to this review as a disability studies academic with no background in writing on drama or the arts more generally, and this was the preferred approach to reviewing expressed by the…

  9. USDA Nutrition Evidence Library: methodology used to identify topics and develop systematic review questions for the birth-to-24-mo population.

    PubMed

    Obbagy, Julie E; Blum-Kemelor, Donna M; Essery, Eve V; Lyon, Joan M G; Spahn, Joanne M

    2014-03-01

    The USDA's Nutrition Evidence Library (NEL) specializes in conducting food- and nutrition-related systematic reviews that are used to inform federal government decision making. To ensure the utility of NEL systematic reviews, the most relevant topics must be addressed, questions must be clearly focused and appropriate in scope, and review frameworks must reflect the state of the science. Identifying the optimal topics and questions requires input from a variety of stakeholders, including scientists with technical expertise, as well as government policy and program leaders. The objective of this article is to describe the rationale and NEL methodology for identifying topics and developing systematic review questions implemented as part of the "Evaluating the evidence base to support the inclusion of infants and children from birth to 24 months of age in the Dietary Guidelines for Americans--the B-24 Project." This is the first phase of a larger project designed to develop dietary guidance for the birth to 24-mo population in the United States. PMID:24452234

  10. Invited review paper: Some outstanding issues in the study of great megathrust earthquakes-The Cascadia example

    NASA Astrophysics Data System (ADS)

    Wang, Kelin; Tréhu, Anne M.

    2016-08-01

    Because of a combination of new observational tools and a flurry of large megathrust earthquakes, tremendous progress has been made in recent years towards understanding the process of great subduction earthquakes at Cascadia and other subduction zones around the world. This review article attempts to clarify some of widely used geodynamic concepts and identify the most important scientific questions for future research related to megathrust behaviour. It is important to specify how the megathrust seismogenic zone has been defined when comparing data and models. Observations and concepts currently used to define the seismogenic zone include: (A) the stability transition in rate-and-state dependent friction; (B) the slip zone of large interplate earthquakes; (C) the distribution of small-medium earthquakes; and (D) the geodetically-determined zone of fault locking. Land-based geodetic measurements indicate that the Cascadia megathrust is locked to some extent, but the degree of locking is not well constrained. The near absence of detectable interplate seismicity, with the exception of a segment near 44.5°N and near the Mendocino Triple Junction, is presently interpreted to indicate full locking along most of Cascadia. Resolving the locking state requires seafloor geodetic measurements. The slip behaviour of the shallowest segment of the megathrust and its tsunamigenic potential are complex and variable. Structural studies combined with modeling have the potential to improve our understanding of the signature left in the structure by the slip history. For several reasons, but mostly because of interseismic viscoelastic stress relaxation, the downdip limit of megathrust locking cannot be reliably constrained by geodetic data. Independent information is needed on the composition and thermal state of fault zone materials. The spatial relationship between the seismogenic zone and the zone of Episodic Tremor and Slip (ETS) remains controversial. Observations from the

  11. Methods used to identify and measure resource use in economic evaluations: a systematic review of questionnaires for older people.

    PubMed

    Martin, Adam; Jones, Alex; Mugford, Miranda; Shemilt, Ian; Hancock, Ruth; Wittenberg, Raphael

    2012-08-01

    This paper presents the findings of a systematic review of full or partial economic evaluations that included questions to service users or their carers to elicit information on the types, amounts or costs of community-based formal social care support provided to people 65 years and older. We have found that studies seldom report use of published validated questions for eliciting information from older people in the UK about their use of formal social care services. Given the political prominence of the debate over funding social care for older people, there remains a need for analysis of policy options. This requires reliable data on the receipt and payment for care. We recommend the development of improved questions on care that are clear, robust and up-to-date with developments in policy and practice. PMID:21751293

  12. Ethical issues in research involving minority populations: the process and outcomes of protocol review by the Ethics Committee of the Faculty of Tropical Medicine, Mahidol University, Thailand

    PubMed Central

    2013-01-01

    Background Recruiting minorities into research studies requires special attention, particularly when studies involve “extra-vulnerable” participants with multiple vulnerabilities, e.g., pregnant women, the fetuses/neonates of ethnic minorities, children in refugee camps, or cross-border migrants. This study retrospectively analyzed submissions to the Ethics Committee of the Faculty of Tropical Medicine (FTM-EC) in Thailand. Issues related to the process and outcomes of proposal review, and the main issues for which clarification/revision were requested on studies, are discussed extensively. Methods The study data were extracted from proposals and amendments submitted to the FTM-EC during the period October 2009 – September 2012, and then analyzed qualitatively and quantitatively. The main issues for clarification/revision were analyzed by thematic content analysis. Results 373 proposals were submitted; 44 studies involved minority groups with 21 extra-vulnerable minorities. All clinical and 2/3 of non-clinical studies submitted for initial review underwent full-board review. For combined clinical and non-clinical study submissions, 92.1% were referred back to the investigators and approved after clarification/revision, while 2.7% were deferred due to major/critical changes, and 2.1% not approved due to substantial violations of ethical principles. The main issues needing clarification/revision differed between all studies and those involving minorities: participant information sheet (62.2% vs. 86.4%), informed consent/assent form (51.2% vs. 86.4%), and research methodology (80.7% vs. 84.1%), respectively. The main ethical issues arising during the meetings, regarding studies involving minorities, included ensuring no exploitation, coercion, or pressure on the minority to participate; methodology not affecting their legal status; considering ethnicity and cultural structure; and providing appropriate compensation. Conclusion Delays in the approval or non

  13. A Comparative Review of Hydrologic Issues Involved in Geologic Storage of CO2 and Injection Disposal of Liquid Waste

    SciTech Connect

    Tsang, C.-F.; Birkholzer, J.; Rutqvist, J.

    2008-04-15

    The paper presents a comparison of hydrologic issues and technical approaches used in deep-well injection and disposal of liquid wastes, and those issues and approaches associated with injection and storage of CO{sub 2} in deep brine formations. These comparisons have been discussed in nine areas: (1) Injection well integrity; (2) Abandoned well problems; (3) Buoyancy effects; (4) Multiphase flow effects; (5) Heterogeneity and flow channeling; (6) Multilayer isolation effects; (7) Caprock effectiveness and hydrogeomechanics; (8) Site characterization and monitoring; and (9) Effects of CO{sub 2} storage on groundwater resources There are considerable similarities, as well as significant differences. Scientifically and technically, these two fields can learn much from each other. The discussions presented in this paper should help to focus on the key scientific issues facing deep injection of fluids. A substantial but by no means exhaustive reference list has been provided for further studies into the subject.

  14. Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker's pneumoconiosis: a comprehensive review.

    PubMed

    Gulumian, M; Borm, P J A; Vallyathan, V; Castranova, V; Donaldson, K; Nelson, G; Murray, J

    2006-01-01

    Clinical detection of silicosis is currently dependent on radiological and lung function abnormalities, both late manifestations of disease. Markers of prediction and early detection of pneumoconiosis are imperative for the implementation of timely intervention strategies. Understanding the underlying mechanisms of the etiology of coal workers pneumoconiosis (CWP) and silicosis was essential in proposing numerous biomarkers that have been evaluated to assess effects following exposure to crystalline silica and/or coal mine dust. Human validation studies have substantiated some of these proposed biomarkers and argued in favor of their use as biomarkers for crystalline silica- and CWP-induced pneumoconiosis. A number of "ideal" biological markers of effect were identified, namely, Clara cell protein-16 (CC16) (serum), tumor necrosis factor-alpha (TNF-alpha) (monocyte release), interleukin-8 (IL-8) (monocyte release), reactive oxygen species (ROS) measurement by chemiluminescence (neutrophil release), 8-isoprostanes (serum), total antioxidant levels measured by total equivalent antioxidant capacity (TEAC), glutathione, glutathione peroxidase activity, glutathione S-transferase activity, and platelet-derived growth factor (PDGF) (serum). TNF-alpha polymorphism (blood cellular DNA) was identified as a biomarker of susceptibility. Further studies are planned to test the validity and feasibility of these biomarkers to detect either high exposure to crystalline silica and early silicosis or susceptibility to silicosis in gold miners in South Africa. PMID:16990219

  15. Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker's pneumoconiosis: A comprehensive review

    SciTech Connect

    Gulumian, M.; Borm, P.J.A.; Vallyathan, V.; Castranova, V.; Donaldson, K.; Nelson, G.; Murray, J.

    2006-09-15

    Clinical detection of silicosis is currently dependent on radiological and lung function abnormalities, both late manifestations of disease. Markers of prediction and early detection of pneumoconiosis are imperative for the implementation of timely intervention strategies. Understanding the underlying mechanisms of the etiology of coal workers pneumoconiosis (CWP) and silicosis was essential in proposing numerous biomarkers that have been evaluated to assess effects following exposure to crystalline silica and/or coal mine dust. Human validation studies have substantiated some of these proposed biomarkers and argued in favor of their use as biomarkers for crystalline silica-and CWP-induced pneumoconiosis. A number of 'ideal' biological markers of effect were identified, namely, Clara cell protein-16 (CC16) (serum), tumor necrosis factor-alpha (TNF-alpha) (monocyte release), interleukin-8 (IL-8) (monocyte release), reactive oxygen species (ROS) measurement by chemiluminescence (neutrophil release), 8-isoprostanes (serum), total antioxidant levels measured by total equivalent antioxidant capacity (TEAC), glutathione, glutathione peroxidase activity, glutathione S-transferase activity, and platelet-derived growth factor (PDGF) (serum). TNF-alpha polymorphism (blood cellular DNA) was identified as a biomarker of susceptibility. Further studies are planned to test the validity and feasibility of these biomarkers to detect either high exposure to crystalline silica and early silicosis or susceptibility to silicosis in gold miners in South Africa.

  16. Statistical Analyses of Scatterplots to Identify Important Factors in Large-Scale Simulations, 1: Review and Comparison of Techniques

    SciTech Connect

    Kleijnen, J.P.C.; Helton, J.C.

    1999-03-24

    The robustness of procedures for identifying patterns in scatterplots generated in Monte Carlo sensitivity analyses is investigated. These procedures are based on attempts to detect increasingly complex patterns in the scatterplots under consideration and involve the identification of (i) linear relationships with correlation coefficients, (ii) monotonic relationships with rank correlation coefficients, (iii) trends in central tendency as defined by means, medians and the Kruskal-Wallis statistic, (iv) trends in variability as defined by variances and interquartile ranges, and (v) deviations from randomness as defined by the chi-square statistic. The following two topics related to the robustness of these procedures are considered for a sequence of example analyses with a large model for two-phase fluid flow: the presence of Type I and Type II errors, and the stability of results obtained with independent Latin hypercube samples. Observations from analysis include: (i) Type I errors are unavoidable, (ii) Type 11errors can occur when inappropriate analysis procedures are used, (iii) physical explanations should always be sought for why statistical procedures identify variables as being important, and (iv) the identification of important variables tends to be stable for independent Latin hypercube samples.

  17. The US framework for understanding, preventing, and caring for the mental health needs of service members who served in combat in Afghanistan and Iraq: a brief review of the issues and the research.

    PubMed

    Castro, Carl Andrew

    2014-01-01

    This paper reviews the psychological health research conducted in the United States in support of combat veterans from Iraq and Afghanistan, using the Military Psychological Health Research Continuum, which includes foundational science, epidemiology, etiology, prevention and screening, treatment, follow-up care, and services research. The review is limited to those studies involving combat veterans and military families. This review discusses perplexing issues regarding the impact of combat on the mental health of service members such as risk and resilience factors of mental health, biomarkers of posttraumatic stress syndrome (PTSD), mental health training, psychological screening, psychological debriefing, third location decompression, combat and suicide, the usefulness of psychotherapy and drug therapy for treating PTSD, role of advanced technology, telemedicine and virtual reality, methods to reduce stigma and barriers to care, and best approaches to the dissemination of evidence-based interventions. The mental health research of special populations such as women, National Guardsmen and reservists, and military families is also presented. The review concludes by identifying future areas of research. PMID:25206943

  18. The US framework for understanding, preventing, and caring for the mental health needs of service members who served in combat in Afghanistan and Iraq: a brief review of the issues and the research

    PubMed Central

    Castro, Carl Andrew

    2014-01-01

    This paper reviews the psychological health research conducted in the United States in support of combat veterans from Iraq and Afghanistan, using the Military Psychological Health Research Continuum, which includes foundational science, epidemiology, etiology, prevention and screening, treatment, follow-up care, and services research. The review is limited to those studies involving combat veterans and military families. This review discusses perplexing issues regarding the impact of combat on the mental health of service members such as risk and resilience factors of mental health, biomarkers of posttraumatic stress syndrome (PTSD), mental health training, psychological screening, psychological debriefing, third location decompression, combat and suicide, the usefulness of psychotherapy and drug therapy for treating PTSD, role of advanced technology, telemedicine and virtual reality, methods to reduce stigma and barriers to care, and best approaches to the dissemination of evidence-based interventions. The mental health research of special populations such as women, National Guardsmen and reservists, and military families is also presented. The review concludes by identifying future areas of research. PMID:25206943

  19. A Review of Methods Applied by the U.S. Geological Survey in the Assessment of Identified Geothermal Resources

    USGS Publications Warehouse

    Williams, Colin F.; Reed, Marshall J.; Mariner, Robert H.

    2008-01-01

    The U. S. Geological Survey (USGS) is conducting an updated assessment of geothermal resources in the United States. The primary method applied in assessments of identified geothermal systems by the USGS and other organizations is the volume method, in which the recoverable heat is estimated from the thermal energy available in a reservoir. An important focus in the assessment project is on the development of geothermal resource models consistent with the production histories and observed characteristics of exploited geothermal fields. The new assessment will incorporate some changes in the models for temperature and depth ranges for electric power production, preferred chemical geothermometers for estimates of reservoir temperatures, estimates of reservoir volumes, and geothermal energy recovery factors. Monte Carlo simulations are used to characterize uncertainties in the estimates of electric power generation. These new models for the recovery of heat from heterogeneous, fractured reservoirs provide a physically realistic basis for evaluating the production potential of natural geothermal reservoirs.

  20. Teaching for Change: Addressing Issues of Difference in the College Classroom. Reprint Series No. 25. Harvard Educational Review.

    ERIC Educational Resources Information Center

    Geismar, Kathryn, Ed.; Nicoleau, Guitele, Ed.

    Contributors to this collection of essays describe how they address issues of race, gender, and class in their college courses as they attempt to ensure that their curricula and class discussions represent the perspectives of all students. Essays include: (1) "Introduction" (Kathryn Giesmar and Guitele Nicoleau); (2) "Dialogue across Differences:…

  1. Immunotoxicity of the colour additive caramel colour III; a review on complicated issues in the safety evaluation of a food additive.

    PubMed

    Houben, G F; Penninks, A H

    1994-08-12

    Food additives can be regarded as the safest constituents of our daily food. Nevertheless, complicated issues with respect to their safety evaluation do also occur. In this review paper, some of these issues are illustrated by the description and evaluation of the research on the immunotoxicity of the food additive Caramel Colour III. Caramel Colour III is commonly used as a color additive in many products for human consumption. Toxicity studies conducted in the seventies demonstrated that administration of Caramel Colour III can cause a reduction in total white blood cell counts in rats, due to reduced lymphocyte counts. Studies reviewed in this paper demonstrated several other effects of Caramel Colour III on the immune system of rodents, including disturbed immune functions and changed resistance in infection models. In addition, studies in rats demonstrated that most of the effects occur only when the animals are fed a diet low in vitamin B6. The imidazole derivative 2-acetyl-4(5)-(1,2,3,4-tetrahydroxy-butyl)-imidazole (THI) was found to be responsible for the immunotoxicity. Issues such as the mechanism of action of THI and the role of vitamin B6 are discussed. Finally, the results of a human intervention study and the observed effect levels of THI in rats are discussed in terms of safety of the use of Caramel Colour III in our daily food supply. PMID:8079366

  2. 40 CFR 21.12 - State issued statements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false State issued statements. 21.12 Section 21.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL SMALL BUSINESS § 21.12 State... as identified in § 21.12(a)(4) of this section, EPA shall review the application and issue...

  3. Supervision, support and mentoring interventions for health practitioners in rural and remote contexts: an integrative review and thematic synthesis of the literature to identify mechanisms for successful outcomes

    PubMed Central

    2014-01-01

    Objective To identify mechanisms for the successful implementation of support strategies for health-care practitioners in rural and remote contexts. Design This is an integrative review and thematic synthesis of the empirical literature that examines support interventions for health-care practitioners in rural and remote contexts. Results This review includes 43 papers that evaluated support strategies for the rural and remote health workforce. Interventions were predominantly training and education programmes with limited evaluations of supervision and mentoring interventions. The mechanisms associated with successful outcomes included: access to appropriate and adequate training, skills and knowledge for the support intervention; accessible and adequate resources; active involvement of stakeholders in programme design, implementation and evaluation; a needs analysis prior to the intervention; external support, organisation, facilitation and/or coordination of the programme; marketing of the programme; organisational commitment; appropriate mode of delivery; leadership; and regular feedback and evaluation of the programme. Conclusion Through a synthesis of the literature, this research has identified a number of mechanisms that are associated with successful support interventions for health-care practitioners in rural and remote contexts. This research utilised a methodology developed for studying complex interventions in response to the perceived limitations of traditional systematic reviews. This synthesis of the evidence will provide decision-makers at all levels with a collection of mechanisms that can assist the development and implementation of support strategies for staff in rural and remote contexts. PMID:24521004

  4. Dietary Issues Inpatients Face With Being Vegetarian

    PubMed Central

    Potter-Dunlop, Julie A.; Tse, Alice M.

    2016-01-01

    This article reviews the literature from 1985 through 2010 on research related to the dietary issues vegetarian inpatients may encounter in the acute care setting. A thematic portrayal of vegetarianism in the context of the inpatient setting is described. Implications for future research and nursing practice are identified. PMID:22157507

  5. At Issue: The Relationship between Student Loans and Low-Income Students' Baccalaureate Attainment: A Literature Review

    ERIC Educational Resources Information Center

    Yu, Hongwei

    2014-01-01

    The study conducts a review on the linkage between student loans and low-income students' baccalaureate degree achievement. Specifically, this study synthesizes literature on low-income students' borrowing patterns, low-income students' baccalaureate degree achievement, as well as the relationship between these two topics. Future research should…

  6. A Review of Agile and Lean Manufacturing as Issues in Selected International and National Research and Development Programs and Roadmaps

    ERIC Educational Resources Information Center

    Castro, Helio; Putnik, Goran D.; Shah, Vaibhav

    2012-01-01

    Purpose: The aim of this paper is to analyze international and national research and development (R&D) programs and roadmaps for the manufacturing sector, presenting how agile and lean manufacturing models are addressed in these programs. Design/methodology/approach: In this review, several manufacturing research and development programs and…

  7. Comprehensive Employment and Training Act. Review and Oversight. Part I: Background and First Year Results. Part II: Public Policy Issues.

    ERIC Educational Resources Information Center

    Employment and Training Administration (DOL), Washington, DC.

    This report reviews the establishment and early performance of the comprehensive manpower system established by the Comprehensive Employment and Training Act (CETA). The report is divided into two major sections. Part 1 examines the background and first year results of the CETA program. The legislative and programmatic antecedents to CETA are…

  8. Reviewing the Evidence on How Teacher Professional Development Affects Student Achievement. Issues & Answers. REL 2007-No. 033

    ERIC Educational Resources Information Center

    Yoon, Kwang Suk; Duncan, Teresa; Lee, Silvia Wen-Yu; Scarloss, Beth; Shapley, Kathy L.

    2007-01-01

    The Regional Educational Laboratory - Southwest (REL Southwest) conducted a systematic and comprehensive review of the research-based evidence on the effects of professional development (PD) on growth in student achievement in three core academic subjects (reading/ELA, mathematics, and science). The primary goal of this study was to address the…

  9. Education for Public Health Capacity in the Nursing Workforce: Findings from a Review of Education and Practice Issues.

    ERIC Educational Resources Information Center

    Latter, Sue; Speller, Viv; Westwood, Greta; Latchem, Susan

    2003-01-01

    Literature review and interviews with nine public health and nursing education informants in Britain indicated that, although National Health Service policy highlights public health, clinical placements in this area are limited and curriculum content needs to be applicable to public health. Needs assessments show skills gaps in practicing nurses…

  10. Strength-based well-being indicators for Indigenous children and families: A literature review of Indigenous communities' identified well-being indicators.

    PubMed

    Rountree, Jennifer; Smith, Addie

    2016-01-01

    Mainstream child and family well-being indicators frequently are based on measuring health, economic, and social deficits, and do not reflect Indigenous holistic and strength-based definitions of health and well-being. The present article is a review of literature that features Indigenous communities' self-identified strength-based indicators of child and family well-being. The literature search included Indigenous communities from across the world, incorporating findings from American Indians and Alaska Natives, First Nations, Native Hawaiians, Māori, Aboriginal Australians, and Sámi communities. Sorting the identified indicators into the quadrants of the Relational Worldview, an Indigenous framework for well-being based on medicine wheel teachings that views health and well-being as a balance among physical, mental, contextual, and spiritual factors, the authors discuss the findings. PMID:27383093

  11. Reviews

    NASA Astrophysics Data System (ADS)

    2001-11-01

    BOOK REVIEW Search for Life BOOK REVIEW Health Physics BOOK REVIEW Language and Literacy in Science Education BOOK REVIEW Science Web Reader—Physics Correction GCSE BOOK REVIEW Physics for Higher Tier GCSE BOOK REVIEW Modular Science GCSE BOOK REVIEW Modular Science for AQA: Foundation level and Higher level GCSE BOOK REVIEW Physics for OCR A GCSE BOOK REVIEW Physics Matters, 3rd edition GCSE BOOK REVIEW Physics GCSE BOOK REVIEW Science Foundations: Physics (new edition) GCSE BOOK REVIEW Target Science: Physics Foundation Tier GCSE BOOK REVIEW Target Science: Physics Foundation Tier: AQA WEB WATCH Medical physics organizations

  12. Energy infrastructure of the United States and projected siting needs: Scoping ideas, identifying issues and options. Documentation report for Chapter 2: Draft report of the Working Group on Energy Facility Siting to the Secretary

    SciTech Connect

    Not Available

    1993-12-01

    This report documents the sources and derivation of the energy demand and infrastructure estimates found in Chapter 2 of ENERGY INFRASTRUCTURE OF THE UNITED STATES AND PROJECTED SITING NEEDS: SCOPING IDEAS, IDENTIFYING ISSUES AND OPTIONS Draft Report of the Department of Energy Working Group on Energy Facility Siting to the Secretary. The first part of this report provides an explanation in narrative form of each table, figure, or infrastructure estimate in Chapter 2, including a complete list of references and personal contacts. Appendix A contains a print out of the calculations used to derive the figures, including references to data sources. Appendix B contains the results of a sensitivity analysis that uses an alternative energy use forecast as its basis. This report should only be used in conjunction with the full contents of Chapter 2.

  13. Research on Racial Issues in American Higher Education.

    ERIC Educational Resources Information Center

    Bennett, Christine I.

    This review of racial issues in American higher education identifies the quest for community amid diversity as the major challenges facing colleges and universities today. The literature reviewed is organized into three parts: (1) the demographics of equity and access in higher education; (2) the legacy of racism in higher education; and (3) the…

  14. Considerations on the aquaculture development and on the use of veterinary drugs: special issue for fluoroquinolones--a review.

    PubMed

    Quesada, Silvia Pilco; Paschoal, Jonas Augusto Rizzato; Reyes, Felix Guillermo Reyes

    2013-09-01

    Aquaculture has become an important source of fish available for human consumption. In order to achieve greater productivity, intensive fish cultivation systems are employed, which can cause greater susceptibility to diseases caused by viruses, bacteria, fungi, and parasites. Antimicrobial substances are compounds used in livestock production with the objectives of inhibiting the growth of microorganisms and treatment or prevention of diseases. It is well recognized that the issues of antimicrobial use in food animals are of global concern about its impact on food safety. This paper present an overview of the aquaculture production in the whole world, raising the particularities in Brazil, highlighting the importance of the use of veterinary drugs in this system of animal food production, and address the potential risks arising from their indiscriminate use and their impacts on aquaculture production as they affect human health and the environment. The manuscript also discusses the analytical methods commonly used in the determination of veterinary drug residues in fish, with special issue for fluroquinolones residues and with emphasis on employment of LC-MS/MS analytical technique. PMID:23909512

  15. Issues Validation: A New Environmental Scanning Technique for Family Life Educators.

    ERIC Educational Resources Information Center

    Weigel, Randy R.; And Others

    1992-01-01

    Three-state study used Issues Validation, environmental scanning process for family life educators that combines literature reviews, professional and public opinion, and survey research to identify issues facing families and youth. Samples of residents, local advisory committees, and community professionals ranked 30 issues facing families and…

  16. Climate change and global agriculture: Recent findings and issues

    SciTech Connect

    Reilly, J.

    1995-08-01

    This paper (a) reviews existing findings on the global impacts of climate change on agriculture, (b) identifies limitations of these findings, and (c) discusses three issues of interest on the Intergovernmental Panel on Climate Change (IPCC). The three issues are as follows: regional effects versus global efficiency: the issue of hunger; climate change, agriculture and economic development; cost and disruption of adaptation to climate change. 45 refs., 3 tabs.

  17. Advanced alarm systems: Display and processing issues

    SciTech Connect

    O`Hara, J.M.; Wachtel, J.; Perensky, J.

    1995-05-01

    This paper describes a research program sponsored by the US Nuclear Regulatory Commission to address the human factors engineering (HFE) deficiencies associated with nuclear power plant alarm systems. The overall objective of the study is to develop HFE review guidance for alarm systems. In support of this objective, human performance issues needing additional research were identified. Among the important issues were alarm processing strategies and alarm display techniques. This paper will discuss these issues and briefly describe our current research plan to address them.

  18. A Retrospective Review of Forensic Odontology Reports Written by the Joint POW/MIA Accounting Command Central Identification Laboratory for Remains Identified from the Korean War.

    PubMed

    Shiroma, Calvin Y

    2016-01-01

    As of August 2014, the Joint POW/MIA Accounting Command has identified the remains of 1980 previously unknown U.S. service members; 280 were from the Korean War. To determine the accuracy and completeness of the available antemortem (AM) dental records, a review of the AM/postmortem (AM/PM) dental record comparisons from 233 Forensic Odontology Reports written in support of remains identified from the Korean War was performed. Seventy-two AM/PM comparisons resulted in exact dental chartings while 161 contained discrepancies which were explainable. Explainable discrepancies include undocumented treatment (103), incorrectly charted third molars as missing (82), differing opinions of specific molars present/missing (20), and erroneous treatment documentation and/or misidentification of teeth present/missing (22, other than molars). Reassessment has revealed varying levels of completeness for our available AM dental records, the need to thoroughly review our computerized comparisons, adjust our comparisons to include molar pattern variations/third molars, and updating our database comparison program. PMID:27404405

  19. Identifying effective behavioural models and behaviour change strategies underpinning preschool- and school-based obesity prevention interventions aimed at 4-6-year-olds: a systematic review.

    PubMed

    Nixon, C A; Moore, H J; Douthwaite, W; Gibson, E L; Vogele, C; Kreichauf, S; Wildgruber, A; Manios, Y; Summerbell, C D

    2012-03-01

    The aim of this comprehensive systematic review was to identify the most effective behavioural models and behaviour change strategies, underpinning preschool- and school-based interventions aimed at preventing obesity in 4-6-year-olds. Searching was conducted from April 1995 to April 2010 using MEDLINE, EMBASE, CINAHL, PsycINFO and The Cochrane Library. Epidemiological studies relevant to the research question with controlled assignment of participants were included in the review, if they had follow-up periods of 6 months or longer. Outcomes included markers of weight gain; markers of body composition; physical activity behaviour changes and dietary behaviour changes. Twelve studies were included in the review. The most commonly used model was social cognitive theory (SCT)/social learning theory (SLT) either as a single model or in combination with other behavioural models. Studies that used SCT/SLT in the development of the intervention had significant favourable changes in one, or more, outcome measures. In addition, interventions that (i) combined high levels of parental involvement and interactive school-based learning; (ii) targeted physical activity and dietary change; and (iii) included long-term follow-up, appeared most effective. It is suggested that interventions should also be focused on developing children's (and parents') perceived competence at making dietary and physical changes. PMID:22309069

  20. Issues in the review of a license application for an above grade low-level radioactive waste disposal facility

    SciTech Connect

    Ringenberg, J.D.

    1993-03-01

    In December 1987, Nebraska was selected by the Central Interstate Compact (CIC) Commission as the host state for the construction of a low-level radioactive waste disposal facility. After spending a year in the site screening process, the Compact`s developer, US Ecology, selected three sites for detailed site characterization. These sites were located in Nemaha, Nuckolls and Boyd Counties. One year later the Boyd County site was selected as the preferred site and additional site characterization studies were undertaken. On July 29, 1990, US Ecology submitted a license application to the Nebraska Department of Environmental Control (now Department of Environmental Quality-NDEQ). This paper will present issues that the NDEQ has dealt with since Nebraska`s selection as the host state for the CIC facility.