Genetics Home Reference: sepiapterin reductase deficiency

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Genetics Home Reference: adolescent idiopathic scoliosis

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Genetics Home Reference: transthyretin amyloidosis

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Genetics Home Reference: spinocerebellar ataxia type 3

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Genetics Home Reference: Brugada syndrome

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Genetics Home Reference: Friedreich ataxia

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Genetics Home Reference: frontonasal dysplasia

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Genetics Home Reference: Schwartz-Jampel syndrome

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Genetics Home Reference: congenital mirror movement disorder

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Genetics Home Reference: Apert syndrome

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Genetics Home Reference: hepatic veno-occlusive disease with immunodeficiency

MedlinePlus

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Genetics Home Reference: 1p36 deletion syndrome

MedlinePlus

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Evaluating Internet Health Information: A Tutorial from the National Library of Medicine

MedlinePlus

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Understanding Medical Words: A Tutorial from the National Library of Medicine

MedlinePlus

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Dialysis: MedlinePlus Health Topic

MedlinePlus

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Thumb sucking

MedlinePlus

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MedlinePlus FAQ: Disease or Condition Information

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Bone Density: MedinePlus Health Topic

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Wilms' Tumor: MedlinePlus Health Topic

MedlinePlus

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Genetics Home Reference: Mowat-Wilson syndrome

MedlinePlus

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78 FR 36552 - National Library of Medicine; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... of Committee: Biomedical Library and Informatics Review Committee. Date: November 14-15, 2013. Time...: National Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda, MD 20892...

77 FR 37684 - National Library of Medicine; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... privacy. Name of Committee: Biomedical Library and Informatics Review Committee. Date: November 15-16.... Place: National Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda...

78 FR 76848 - National Library of Medicine; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-19

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... privacy. Name of Committee: Biomedical Library and Informatics Review Committee. Date: March 6-7, 2014...: National Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda, MD 20892...

78 FR 18358 - National Library of Medicine; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-26

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... privacy. Name of Committee: Biomedical Library and Informatics Review Committee. Date: June 6-7, 2013...: National Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda, MD 20892...

76 FR 77239 - National Library of Medicine; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... privacy. Name of Committee: Biomedical Library and Informatics Review Committee. Date: March 1-2, 2012...: National Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda, MD 20892...

77 FR 17488 - National Library of Medicine ; Notice of Closed Meetings

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2012-03-26

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... privacy. Name of Committee: Biomedical Library and Informatics Review Committee Date: June 7-8, 2012. Time... Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda, MD 20892. Time...

75 FR 13136 - National Library of Medicine; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... personal privacy. Name of Committee: Biomedical Library and Informatics Review Committee. Date: June 10-11...: National Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda, MD 20892...

77 FR 17488 - National Library of Medicine Notice of Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-26

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... potential titles to be indexed by the National Library of Medicine and the discussions would likely to... . Place: National Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda...

76 FR 80953 - National Library of Medicine Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... of individual intramural programs and projects conducted by the National Library of Medicine... Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda, MD 20892. Closed: 12 p.m. to 2...

77 FR 39715 - National Library of Medicine; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-05

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... of individual intramural programs and projects conducted by the National Library of Medicine... Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda, MD 20892. Closed: 12:00 p.m...

76 FR 61106 - Notice of Intent To Prepare an Environmental Impact Statement

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-03

... Environmental Protection, Office of Research Facilities, NIH, B13/2S11, 9000 Rockville Pike, Bethesda, Maryland... Institutes of Health (NIH), one of the world's largest biomedical research facilities and the Federal government's focal point for medical and behavioral research. The NIH Animal Center at Poolesville is a major...

Effect of Hypohydration and Altitude Exposure on Aerobic Exercise Performance and Acute Mountain Sickness

DTIC Science & Technology

2010-09-01

code) 2010 Journal Article-Journal of Applied Physiology Effect of hypohydration and altitude exposure on aerobic exercise performance and acute...1563. Visit our website at http://www.the-aps.org/. Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. Copyright © 2010 by the American... Physiological Society. those papers emphasizing adaptive and integrative mechanisms. It is published 12 times a year (monthly) by the American

FASEB (Federation of American Societies for Experimental Biology) Summer Research on Neuronal Cell Cultures at Saxton’s River, Vermont on 12-17 August 1984.

DTIC Science & Technology

1984-08-17

AD-i5 81@ FASEB (FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY ) SUMMER..CU) FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY BET...UNIT NUMBERS Robert W. Krauss, Executive Director I * LEO Federation of American Societies for Experimental, NR 685-003 * Biology , 9650 Rockville Pike...Bethesda, MD 20814 *.CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE ’%Federation f American Societies for I Experimental Biology , 9650

77 FR 38341 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... Pike, Rockville, Maryland. Wednesday, July 11, 2012, Conference Room T2-B1, 11545 Rockville Pike... U.S.C. 552b(c)(4)] Thursday, July 12, 2012, Conference Room T2-B1, 11545 Rockville Pike, Rockville... Bottom,'' and (2) NUREG/CR-7040, ``Evaluation of JNES Equipment Fragility Tests for Use in Seismic...

77 FR 24229 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-23

... Pike, Rockville, Maryland. Thursday, May 10, 2012, Conference Room T2-B1, 11545 Rockville Pike...)]. 9:45 a.m.-11:45 a.m.: Selected Chapters of the Safety Evaluation Report (SER) with Open Items...)]. Friday, May 11, 2012, Conference Room T2-B1, 11545 Rockville Pike, Rockville, Maryland 8:30 a.m.-8:35 a.m...

76 FR 70778 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-15

... Pike, Rockville, Maryland. Thursday, December 1, 2011, Conference Room T2-B1, 11545 Rockville Pike... subsequent COL application for Levy County, Units 1 and 2, and the NRC staff's associated safety evaluation... pursuant to 5 U.S.C. 552b(c)(4).] Friday, December 2, 2011, Conference Room T2-B1, 11545 Rockville Pike...

Pikes Peak, Colorado

USGS Publications Warehouse

Brunstein, Craig; Quesenberry, Carol; Davis, John; Jackson, Gene; Scott, Glenn R.; D'Erchia, Terry D.; Swibas, Ed; Carter, Lorna; McKinney, Kevin; Cole, Jim

2006-01-01

For 200 years, Pikes Peak has been a symbol of America's Western Frontier--a beacon that drew prospectors during the great 1859-60 Gold Rush to the 'Pikes Peak country,' the scenic destination for hundreds of thousands of visitors each year, and an enduring source of pride for cities in the region, the State of Colorado, and the Nation. November 2006 marks the 200th anniversary of the Zebulon M. Pike expedition's first sighting of what has become one of the world's most famous mountains--Pikes Peak. In the decades following that sighting, Pikes Peak became symbolic of America's Western Frontier, embodying the spirit of Native Americans, early explorers, trappers, and traders who traversed the vast uncharted wilderness of the Western Great Plains and the Southern Rocky Mountains. High-quality printed paper copies of this poster are available at no cost from Information Services, U.S. Geological Survey (1-888-ASK-USGS).

77 FR 58420 - Advisory Committee On Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-20

... Pike, Rockville, Maryland. Thursday, October 4, 2012, Conference Room T2-B1, 11545 Rockville Pike....: Safety Evaluation Report (SER) Associated with WCAP-16793-NP, Revision 2, ``Evaluation of Long-Term..., ``Evaluation of JNES Equipment Fragility Tests for Use in Seismic Probabilistic Risk Assessments for U.S...

78 FR 18375 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-26

... Pike, Rockville, Maryland. Thursday, April 11, 2013, Conference Room T2-B1, 11545 Rockville Pike..., ``Westinghouse BWR ECCS Evaluation Model: Supplement 5--Application to the ABWR,'' Revision 0 (Open/Closed)--The...-17116-P, ``Westinghouse BWR Emergency Core Coolant System (ECCS) Evaluation Model: Supplement 5,'' and...

77 FR 51580 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-24

... Pike, Rockville, Maryland. Thursday, September 6, 2012, Conference Room T2-B1, 11545 Rockville Pike... p.m.-3:15 p.m.: Selected Chapters of the Safety Evaluation Reports (SERs) with Open Items Associated... and Peach Bottom,'' and (2) NUREG/CR-7040, ``Evaluation of JNES Equipment Fragility Tests for Use in...

78 FR 70078 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-22

... Pike, Rockville, Maryland. Wednesday, December 4, 2013, Conference Room T2-B1, 11545 Rockville Pike....: Selected Chapters of the Safety Evaluation Report (SER) With Open Items Associated With the Calvert Cliffs...)(4).] 10:45 a.m.-12:45 p.m.: Topical Report and Selected Chapters of the Safety Evaluation Reports...

Introduced northern pike predation on salmonids in southcentral Alaska

USGS Publications Warehouse

Sepulveda, Adam J.; Rutz, David S.; Ivey, Sam S.; Dunker, Kristine J.; Gross, Jackson A.

2013-01-01

Northern pike (Esox lucius) are opportunistic predators that can switch to alternative prey species after preferred prey have declined. This trophic adaptability allows invasive pike to have negative effects on aquatic food webs. In Southcentral Alaska, invasive pike are a substantial concern because they have spread to important spawning and rearing habitat for salmonids and are hypothesised to be responsible for recent salmonid declines. We described the relative importance of salmonids and other prey species to pike diets in the Deshka River and Alexander Creek in Southcentral Alaska. Salmonids were once abundant in both rivers, but they are now rare in Alexander Creek. In the Deshka River, we found that juvenile Chinook salmon (Oncorhynchus tshawytscha) and coho salmon (O. kisutch) dominated pike diets and that small pike consumed more of these salmonids than large pike. In Alexander Creek, pike diets reflected the distribution of spawning salmonids, which decrease with distance upstream. Although salmonids dominated pike diets in the lowest reach of the stream, Arctic lamprey (Lampetra camtschatica) and slimy sculpin (Cottus cognatus) dominated pike diets in the middle and upper reaches. In both rivers, pike density did not influence diet and pike consumed smaller prey items than predicted by their gape-width. Our data suggest that (1) juvenile salmonids are a dominant prey item for pike, (2) small pike are the primary consumers of juvenile salmonids and (3) pike consume other native fish species when juvenile salmonids are less abundant. Implications of this trophic adaptability are that invasive pike can continue to increase while driving multiple species to low abundance.

Introduced northern pike consumption of salmonids in Southcentral Alaska

USGS Publications Warehouse

Sepulveda, Adam J.; Rutz, David S.; Dupuis, Aaron W; Shields, Patrick A; Dunker, Kristine J.

2015-01-01

The impacts of introduced northern pike (Esox lucius) on salmonid populations have attracted much attention because salmonids are popular subsistence, sport and commercial fish. Concern over the predatory effects of introduced pike on salmonids is especially high in Southcentral Alaska, where pike were illegally introduced to the Susitna River basin in the 1950s. We used pike abundance, growth, and diet estimates and bioenergetics models to characterise the realised and potential consumptive impacts that introduced pike (age 2 and older) have on salmonids in Alexander Creek, a tributary to the Susitna River. We found that juvenile salmonids were the dominant prey item in pike diets and that pike could consume up to 1.10 metric tons (realised consumption) and 1.66 metric tons (potential consumption) of juvenile salmonids in a summer. Age 3–4 pike had the highest per capita consumption of juvenile salmonids, and age 2 and age 3–4 pike had the highest overall consumption of juvenile salmonid biomass. Using historical data on Chinook salmon and pike potential consumption of juvenile salmonids, we found that pike consumption of juvenile salmonids may lead to collapsed salmon stocks in Alexander Creek. Taken together, our results indicate that pike consume a substantial biomass of juvenile salmonids in Alexander Creek and that coexistence of pike and salmon is unlikely without management actions to reduce or eliminate introduced pike.

77 FR 68162 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Regulatory...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... Water Reactors,'' Revision 2, and Regulatory Guide 1.79.1, ``Initial Test Program of Emergency Core... White Flint North building, 11555 Rockville Pike, Rockville, MD. After registering with security, please...

75 FR 36429 - Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-25

.... Place: Legacy Hotel and Meeting Center, 1775 Rockville Pike, Rockville, MD 20852. Contact Person: Peter..., 301-435-6902, PETER[email protected] . (Catalogue of Federal Domestic Assistance Program Nos. 93.864...

The roles of PIKE in tumorigenesis

PubMed Central

Qi, Qi; Ye, Keqiang

2013-01-01

Tumorigenesis is the process by which normal cells evolve the capacity to evade and overcome the constraints usually placed upon their growth and survival. To ensure the integrity of organs and tissues, the balance of cell proliferation and cell death is tightly maintained. The proteins controlling this balance are either considered oncogenes, which promote tumorigenesis, or tumor suppressors, which prevent tumorigenesis. Phosphoinositide 3-kinase enhancer (PIKE) is a family of GTP-binding proteins that possess anti-apoptotic functions and play an important role in the central nervous system. Notably, accumulating evidence suggests that PIKE is a proto-oncogene involved in tumor progression. The PIKE gene (CENTG1) is amplified in a variety of human cancers, leading to the resistance against apoptosis and the enhancement of invasion. In this review, we will summarize the functions of PIKE proteins in tumorigenesis and discuss their potential implications in cancer therapy. PMID:23770988

21 CFR 201.25 - Bar code label requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857 (requests... Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Bar code label requirements. 201.25 Section 201.25...

77 FR 30029 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

..., Rockville, Maryland. Wednesday, June 6, 2012, Conference Room T2-B1, 11545 Rockville Pike, Rockville... evaluation of the Fukushima Dai-ichi accident. 12:45 p.m.-2:15 p.m.: Proposed Revision 1 to Regulatory Guide... proprietary, pursuant to 5 U.S.C. 552b(c)(4)]. Thursday, June 7, 2012, Conference Room T2-B1, 11545 Rockville...

10 CFR 73.26 - Transportation physical protection systems, subsystems, components, and procedures.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) Only containers weighing 5,000 lbs or more shall be shipped on open rail cars. (4) A voice... standards is available for inspection at the NRC Library, 11545 Rockville Pike, Rockville, Maryland 20852...

Phototaxis of larval and juvenile northern pike

USGS Publications Warehouse

Zigler, S.J.; Dewey, M.R.

1995-01-01

Age- Phi northern pike Esox lucius prefer vegetated habitats that are difficult to sample with standard towed gears. Light traps can be effective for sampling larval fishes in dense vegetation, given positive phototaxis of fish. We evaluated the phototactic response of young northern pike by comparing the catches of larvae and juveniles obtained with plexiglass traps deployed with a chemical light stick versus traps deployed without a light source (controls) in a laboratory raceway and in a vegetated pond. In the laboratory tests, catches of protolarvae and mesolarvae in lighted traps were 11-35 times greater than catches in control traps. The catches of juvenile northern pike in field and laboratory experiments were 3-15 times greater in lighted traps than in control traps, even though the maximum body width of the larger juveniles was similar to the width of the entrance slots of the traps (5 mm). Larval and juvenile northern pike were photopositive; thus, light traps should effectively sample age-0 northern pike for at least 6 weeks after hatching.

78 FR 32476 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital I&C...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

..., June 4, 2013--1:00 p.m. Until 5:00 p.m. The Subcommittee will review and discuss all cyber security... Flint North building, 11555 Rockville Pike, Rockville, MD. After registering with security, please...

75 FR 1831 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on AP1000...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-13

...-3, 2010, 11545 Rockville Pike, Room T2-B1, Rockville, Maryland. The meeting will be open to public... the Draft Safety Evaluation Report associated with the amendment to the Westinghouse AP1000 Design...

78 FR 70064 - Submission for OMB Review; 30-day Comment Request: Generic Clearance To Support Programs and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-22

... stating that the agency should spend more money on funding prevention research. An email response was sent... Institute, 11400 Rockville Pike, Room 707, Rockville, MD 20852 or call non-toll- free number 301-480-0541 or...

77 FR 64792 - Radio Broadcasting Services; Pike Road, AL

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-23

...] Radio Broadcasting Services; Pike Road, AL AGENCY: Federal Communications Commission. ACTION: Proposed... Corporation, Inc., proposing the allotment of Channel 228A at Pike Road, Alabama, as the community's second local service. A staff engineering analysis indicates that Channel 228A can be allotted to Pike Road...

77 FR 38761 - Radio Broadcasting Services; Pike Road, AL

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

... Broadcasting Services; Pike Road, AL AGENCY: Federal Communications Commission. ACTION: Proposal rule..., Inc., proposing the allotment of Channel 228A at Pike Road, Alabama, as the community's second local... Pike Road allotment. It is the Commission's policy to refrain from making an allotment to a community...

77 FR 2242 - Radio Broadcasting Services; Pike Road, AL

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-17

...] Radio Broadcasting Services; Pike Road, AL AGENCY: Federal Communications Commission. ACTION: Proposed... Corporation, Inc., proposing the allotment of Channel 228A at Pike Road, Alabama, as its second local service. A staff engineering analysis indicates that Channel 228A can be allotted to Pike Road consistent...

78 FR 24441 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Evolutionary...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-25

... Reactor (U.S. EPR) will hold a meeting on May 8-9, 2013, Room T-2B1, 11545 Rockville Pike, Rockville... License Application (COLA) associated with the U.S. EPR Design Control Document (DCD). The Subcommittee...

75 FR 7633 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR; Notice...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-22

... meeting on March 3, 2010, at 11545 Rockville Pike, T2-B3, Rockville, Maryland. The entire meeting will be... selected chapters (Chapters 4 and 5) of the Safety Evaluation Report with Open Items associated with the U...

75 FR 4882 - Meeting of the ACRS Subcommittee on EPR; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-29

... meeting on February 18-19, 2010, 11545 Rockville Pike, T2-B3, Rockville, Maryland. The entire meeting will..., 2010, 8:30 p.m.-5 p.m. The Subcommittee will review selected chapters of the Safety Evaluation Report...

78 FR 66029 - National Cancer Institute; Amended Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-04

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, October 03, 2013, 08:00 a.m. to October 04, 2013, 05:00 p.m., Hilton Rockville Hotel, 1750 Rockville Pike, Rockville,...

78 FR 31570 - National Cancer Institute: Amended Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute: Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, June 20, 2013, 03:00 p.m. to June 21, 2013, 06:00 p.m., Hilton Washington/Rockville, 1750 Rockville Pike, Rockville,...

78 FR 7794 - National Cancer Institute Amended; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute Amended; Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, March 11, 2013, 8:00 a.m. to March 12, 2013, 5:00 p.m., Hilton Washington/Rockville, 1750 Rockville Pike, Rockville,...

76 FR 17362 - Advisory Committee on the Medical Uses of Isotopes: Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-29

... badges and complete self evaluations. Date and Time for Open Sessions: April 11, 2011, from 9 a.m. to 5 p... Commission, Two White Flint North Building, Room T2-B3, 11545 Rockville Pike, Rockville, Maryland 20852. FOR...

75 FR 12804 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR; Notice...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-17

... meeting on April 6, 2010, at 11545 Rockville Pike, T2-B1, Rockville, Maryland. The entire meeting will be... Chapters 11 and 16 of the Safety Evaluation Report with Open Items associated with the U.S. EPR Design...

75 FR 7632 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the Subcommittee on Advanced Boiling...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-22

... March 2, 2010, at 11545 Rockville Pike, Rockville, Maryland, Room T2 B3. The meeting will be open to... chapters (1, 4, 11, 12, 15 and 18) of the Safety Evaluation Report with Open Items associated with the STP...

75 FR 73136 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

.... Place: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. Status: Public and.... Affirmation Session (Public Meeting) (Tentative). a. Tennessee Valley Authority (Watts Bar Nuclear Plant, Unit 2), Southern Alliance for Clean Energy's Petition for Interlocutory Review of LBP-10-12 (Denying...

75 FR 21046 - Advisory Committee on Reactor Safeguards

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-22

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards In accordance with the... on Reactor Safeguards (ACRS) will hold a meeting on May 6-8, 2010, 11545 Rockville Pike, Rockville....: Boiling Water Reactor (BWR) Owners Group (BWROG) Topical Report NEDC-33347P, ``Containment Overpressure...

10 CFR 60.4 - Communications and records.

Code of Federal Regulations, 2012 CFR

2012-01-01

... NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC... offices at 11555 Rockville Pike, Rockville, Maryland; or, where practicable, by electronic submission, for example, via Electronic Information Exchange, or CD-ROM. Electronic submissions must be made in a manner...

75 FR 33736 - List of Approved Spent Fuel Storage Casks: MAGNASTOR System, Revision 1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

... Management Programs, U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001, telephone (301) 415- 6219..., 11555 Rockville Pike, Rockville, Maryland. NRC's Agencywide Documents Access and Management System... M. McCausland, Office of Federal and State Materials and Environmental Management Programs, U.S...

78 FR 69459 - Vogtle Unit 3 Combined License

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-19

... AGENCY: Nuclear Regulatory Commission. ACTION: Determination of inspections, tests, analyses, and... the inspections, tests, and analyses have been successfully completed, and that the specified... public documents at the NRC's PDR, Room O1-F21, One White Flint North, 11555 Rockville Pike, Rockville...

78 FR 73894 - Vogtle Unit 4 Combined License

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-09

... AGENCY: Nuclear Regulatory Commission. ACTION: Determination of inspections, tests, analyses, and... the inspections, tests, and analyses have been successfully completed, and that the specified... public documents at the NRC's PDR, Room O1-F21, One White Flint North, 11555 Rockville Pike, Rockville...

75 FR 22817 - Emerging Infectious Diseases: Evaluation to Implementation for Transfusion and Transplantation...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

... Quantitative Risk Assessment: Blood Safety and Availability; Public Workshops AGENCY: Food and Drug... and Transplantation Safety'' (EID public workshop) and ``Quantitative Risk Assessment: Blood Safety... Research (HFM-302), Food and Drug Administration, 1401 Rockville Pike, Suite 550N, Rockville, MD 20852-1448...

78 FR 12331 - Request for Nominations for Voting and/or Nonvoting Consumer Representatives on Public Advisory...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-22

... Selection Process for Nominations for Voting and/or Nonvoting Consumer Representatives on Public Advisory... statements of interest from consumer organizations interested in participating in the selection process and... Evaluation and Vaccines and Related Biological Products. Research, 1401 Rockville Pike (HFM-71), Rockville...

78 FR 8202 - Meeting of the Joint ACRS Subcommittees on Thermal Hydraulic Phenomena and Materials, Metallurgy...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the Joint ACRS Subcommittees on Thermal Hydraulic Phenomena and Materials, Metallurgy and Reactor Fuels; Notice... Reactor Fuels will hold a meeting on February 20, 2013, Room T-2B1, 11545 Rockville Pike, Rockville...

75 FR 8154 - Advisory Committee on Reactor Safeguards

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-23

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards In accordance with the... on Reactor Safeguards (ACRS) will hold a meeting on March 4-6, 2010, 11545 Rockville Pike, Rockville....-12 p.m.: New Advanced Reactor Designs (Open)--The Committee will hear presentations by and hold...

76 FR 5218 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-28

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR); Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR) will hold a meeting on February 8, 2011, 11545 Rockville Pike, Rockville, MD...

76 FR 11525 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Reliability...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-02

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Reliability and Probabilistic Risk Assessment (PRA); Notice of Meeting The ACRS Subcommittee on Reliability and Probabilistic Risk Assessment (PRA), Room T-2B1, 11545 Rockville Pike, Rockville, Maryland...

78 FR 8360 - Addition of South Sudan to the Restricted Destinations List

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-06

... of information for this final rule. You can access information related to this rule, which the NRC... and Management System (ADAMS): You may access publicly available documents online in the NRC Library... White Flint North, 11555 Rockville Pike, Rockville, Maryland 20852. FOR FURTHER INFORMATION CONTACT...

77 FR 52371 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-29

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on September 5, 2012, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. [[Page 52372

77 FR 41985 - Use of Influenza Disease Models To Quantitatively Evaluate the Benefits and Risks of Vaccines: A...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-17

... Evaluation and Research (CBER) and suggestions for further development. The public workshop will include... Evaluation and Research (HFM-210), Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville... models to generate quantitative estimates of the benefits and risks of influenza vaccination. The public...

75 FR 32230 - Meetings; Sunshine Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-07

.... Place: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. Status: Public and closed. Additional Items To Be Considered: Wednesday, June 9, 2010 1:25 p.m. Affirmation Session (Public Meeting) (Tentative). a. Review of Final Rule Package, Export and Import of Nuclear Equipment and Material...

77 FR 30887 - Amendments to Sterility Test Requirements for Biological Products; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-24

... Biological Products; Correction AGENCY: Food and Drug Administration, HHS. ACTION: Final rule, correction... Evaluation and Research (HFM-17), Food and Drug Administration, 1401 Rockville Pike, Suite 200N, Rockville... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Parts 600, 610, and...

76 FR 60506 - Request for Notification From Industry Organizations Interested in Participating in the Selection...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

... Products Advisory Committee AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food... Biological Products Advisory Committee for the Center for Biologics Evaluation and Research (CBER) notify FDA... Evaluation and Research (HFM-71), Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448...

77 FR 7588 - Blood Products Advisory Committee; Cancellation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-13

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001] Blood Products Advisory Committee; Cancellation AGENCY: Food and Drug Administration, HHS. ACTION... Research (HFM-71), Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, Contact 1- 301...

Age and growth of pike (Esox lucius) in Chivyrkui Bay, Lake Baikal

USGS Publications Warehouse

Owens, Randall W.; Pronin, Nikolai M.

2000-01-01

The purpose of this study was to describe age and growth of pike (Esox lucius) in Lake Baikal. Pike were collected with gill nets and by angling in Chivyrkui Bay in late July-early August 1993 and by gill nets in June 1995. Total length (mm), weight (g), and sex were recorded and scales and cleithra were collected for aging. In 1993, pike, ages 1 to 3, ranged in length from 331 to 810 mm and in 1995 , pike, ages 2 to 10, ranged in length from 365 to 1,111 mm but only three percent were age 7 or older. Most growth in length occurred during the first two years of life. The length-weight relation for pike from Chivyrkui Bay was similar to that of pike from the St. Lawrence River. Calculated total length of pike from Lake Baikal equalled or exceeded the lengths of pike from lakes Erie or Ontario. Good agreement was found between ages from cleithra and from scales. Lengths at age in June 1995 (N=108) varied widely among pike. Females were generally larger than males at a given age among fish age-3 and older. When compared with the circumpolar growth standard, based on the von Bertalanffy growth curve, growth of Lake Baikal pike exceeded all other Asian populations, and equalled or exceeded many other northern hemisphere populations.

78 FR 31987 - Advisory Committee On Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Materials...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-28

... NUCLEAR REGULATORY COMMISSION Advisory Committee On Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels will hold a meeting on June 4, 2013, Room T-2B1, 11545 Rockville Pike, Rockville...

76 FR 34778 - Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Materials...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-14

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels will hold a meeting on June 23, 2011, Room T-2B3, 11545 Rockville Pike, Rockville...

78 FR 29159 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Materials...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-17

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels will hold a meeting on May 22, 2013, Room T-2B1, 11545 Rockville Pike, Rockville...

78 FR 34677 - Advisory Committee On Reactor Safeguards (ACRS); Meeting of the Acrs Subcommittee on Materials...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-10

... NUCLEAR REGULATORY COMMISSION Advisory Committee On Reactor Safeguards (ACRS); Meeting of the Acrs Subcommittee on Materials, Metallurgy & Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels will hold a meeting on June 17, 2013, Room T-2B1, 11545 Rockville Pike, Rockville...

21 CFR 203.37 - Investigation and notification requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... of Compliance, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New... Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Investigation and notification requirements. 203...

78 FR 27116 - Draft Guidance for Industry on Charging for Investigational Drugs Under an Investigational New...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-09

... Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 51, rm. 2201, Silver Spring, MD... Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville, MD 20852...: Colleen L. Locicero, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New...

75 FR 27840 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Radiation...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-18

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Radiation Protection and Nuclear Materials The ACRS Subcommittee on Radiation Protection and Nuclear Materials will hold a meeting on May 18, 2010, Room T-2B1, 11545 Rockville Pike, Rockville...

75 FR 27841 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Radiation...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-18

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Radiation Protection and Nuclear Materials The ACRS Subcommittee on Radiation Protection and Nuclear Materials will hold a meeting on May 18, 2010, Room T-2B1, 11545 Rockville Pike, Rockville...

75 FR 58447 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Radiation...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-24

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Radiation Protection and Nuclear Materials The ACRS Subcommittee on Radiation Protection and Nuclear Materials will hold a meeting on October 22, 2010, Room T-2B1, 11545 Rockville Pike, Rockville...

75 FR 51499 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Thermal...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Thermal Hydraulics Phenomena The ACRS Subcommittee on Thermal Hydraulics Phenomena will hold a meeting on September 7, 2010, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting...

75 FR 57536 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Thermal...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-21

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Thermal Hydraulic Phenomena The ACRS Subcommittee on Thermal Hydraulic Phenomena will hold a meeting on October 18, 2010, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting...

76 FR 24540 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Materials...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-02

... Nuclear Regulatory Commission Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels will hold a meeting on May 10, 2011, Room T-2B1, 11545 Rockville Pike, Rockville...

75 FR 7489 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-19

... review and evaluate grant applications. Place: Legacy Hotel and Meeting Center, 1775 Rockville Pike, Rockville, MD 20852. Contact Person: Lalita D. Palekar, PhD, Scientific Review Officer, Special Review and... Institute Special Emphasis Panel; NCI Cancer Nanotechnology Training (R25) and Career Development Award (K99...

76 FR 24924 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-03

... use of automated collection techniques or other forms of information technology? The public may examine and have copied for a fee publicly available documents, including the draft supporting statement, at the NRC's Public Document Room, O1-F21, One White Flint North, 11555 Rockville Pike, Rockville...

78 FR 34134 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-06

... action to submit an information collection request to the Office of Management and Budget (OMB) and... fee, publicly available documents, including the draft supporting statement, at the NRC's Public Document Room, Room O-1F21, One White Flint North, 11555 Rockville Pike, Rockville, Maryland 20852. OMB...

75 FR 68802 - Report on the Performance of Drug and Biologics Firms in Conducting Postmarketing Requirements...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-09

.... This notice is the Agency's report on the status of the studies and clinical trials that applicants... Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 22, Rm... and Research (HFM- 25), Food and Drug Administration, 1400 Rockville Pike, Rockville, MD 20852, 301...

77 FR 8885 - Draft Guidance for Industry on Biosimilars: Questions and Answers Regarding Implementation of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 51, Rm. 2201, Silver... Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Suite 200N, Rockville... Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 51, Rm...

77 FR 1089 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-09

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0002] Sunshine Act Meetings AGENCY: Agency Holding the Meetings: Nuclear Regulatory Commission DATES: Week of January 9, 2012. Place: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. Status: Public and Closed. Additional Items To Be Considered: Week of January 9, 2012 Wednesday,...

78 FR 52932 - Guidance for Institutional Review Boards, Clinical Investigators, and Sponsors: Institutional...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-27

... guidance to the Division of Drug Information, Center for Drug Evaluation and Research, Food and Drug... Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville, MD 20852...-regulated products in determining that the proposed research satisfies the criteria for approval contained...

77 FR 16278 - Advisory Committee on Reactor Safeguards: Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-20

..., 11545 Rockville Pike, Rockville, Maryland. Thursday, April 12, 2012, Conference Room T2-B1, 11545....: Selected Chapters of the Safety Evaluation Report (SER) with Open Items Associated with the Calvert Cliffs... chapters of the NRC staff's Safety Evaluation Report (SER) with open items associated with the Calvert...

77 FR 59678 - Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Advanced...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-28

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor; Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR) will hold a meeting on October 2, 2012, Room T-2B1, 11545 Rockville Pike, Rockville...

76 FR 34276 - Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Advanced...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-13

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor; Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR) will hold a meeting on June 21, 2011, Room T-2B1, 11545 Rockville Pike, Rockville...

21 CFR 203.70 - Application for a reward.

Code of Federal Regulations, 2010 CFR

2010-04-01

... for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver... Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Application for a reward. 203.70 Section 203.70...

77 FR 24745 - Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Thermal...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-25

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Thermal Hydraulic Phenomena; Notice of Meeting The ACRS Subcommittee on Thermal Hydraulic Phenomena will hold a meeting on May 8-9, 2012, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The...

76 FR 7882 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital I&C...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-11

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital I&C Systems The ACRS Subcommittee on Digital Instrumentation & Control (DI&C) Systems will hold a meeting on February 23, 2011, Room T-2B3, 11545 Rockville Pike, Rockville, Maryland. The...

77 FR 45699 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on August 14, 2012, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to...

78 FR 65008 - Advisory Committee On Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee On Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-30

... NUCLEAR REGULATORY COMMISSION Advisory Committee On Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee On Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on November 5, 2013, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to...

77 FR 68161 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on December 4, 2012, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to...

77 FR 74697 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-17

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on January 18, 2013, Room T-2B3, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to...

78 FR 50457 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-19

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on September 4, 2013, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to...

78 FR 27442 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-10

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on May 23, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public...

78 FR 51752 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on September 18, 2013, Room T-2B3, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open...

77 FR 59676 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-28

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on October 3, 2012, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to...

77 FR 64147 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-18

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on October 31, 2012, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to...

78 FR 22562 - Agency Information Collection Activities; Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-16

... submit an information collection request to the Office of Management and Budget (OMB) and solicitation of... fee publicly available documents, including the draft supporting statement, at the NRC's Public Document Room, Room O-1F21, One White Flint North, 11555 Rockville Pike, Rockville, Maryland 20852. The OMB...

78 FR 35329 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-12

... action to submit an information collection request to the Office of Management and Budget (OMB) and... fee publicly available documents, including the draft supporting statement, at the NRC's Public Document Room, Room O-1F21, One White Flint North, 11555 Rockville Pike, Rockville, Maryland 20852. The OMB...

77 FR 13339 - Report on the Performance of Drug and Biologics Firms in Conducting Postmarketing Requirements...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-06

.... This notice is the Agency's report on the status of the studies and clinical trials that applicants... Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 22, Rm... and Research (HFM-17), Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville, MD...

77 FR 20025 - Draft Guidance for Industry on Compliance Policy for Reporting Drug Sample Distribution...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-03

... Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 51, Rm. 2201, Silver Spring, MD... Evaluation and Research (CBER), Food and Drug Administration, 1401 Rockville Pike, Suite 200N, Rockville, MD... Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 51, Rm. 4288, Silver Spring, MD...

77 FR 26162 - Amendments to Sterility Test Requirements for Biological Products

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-03

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Parts 600, 610, and... AGENCY: Food and Drug Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug Administration...), Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville, MD 20852- 1448, 301-827-6210...

21 CFR 1.101 - Notification and recordkeeping.

Code of Federal Regulations, 2011 CFR

2011-04-01

... products and devices regulated by the Center for Biologics Evaluation and Research—Division of Case... Research, Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville, MD 20852-1448. (ii) For... Research—Division of New Drugs and Labeling Compliance, Center for Drug Evaluation and Research, Food and...

21 CFR 1.101 - Notification and recordkeeping.

Code of Federal Regulations, 2010 CFR

2010-04-01

... products and devices regulated by the Center for Biologics Evaluation and Research—Division of Case... Research, Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville, MD 20852-1448. (ii) For... Research—Division of New Drugs and Labeling Compliance, Center for Drug Evaluation and Research, Food and...

21 CFR 807.90 - Format of a premarket notification submission.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville... to the Central Document Room, Center for Drug Evaluation and Research, Food and Drug Administration... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Format of a premarket notification submission. 807...

Impacts of Northern Pike on stocked Rainbow Trout in Pactola Reservoir, South Dakota

USGS Publications Warehouse

Scheibel, Natalie C.; Dembkowski, Daniel J.; Davis, Jacob L.; Chipps, Steven R.

2016-01-01

Establishment of nonnative Northern Pike Esox lucius in Pactola Reservoir, South Dakota, has prompted concern among biologists about the influence of this species on the lake’s intensively managed salmonid fisheries. Ancedotal information suggests that catch rates of Rainbow Trout Oncorhynchus mykiss have declined while mean size and abundance of Northern Pike has increased, although quantitative information on diet and growth of the Northern Pike population is lacking. To address potential interactions between Northern Pike and Rainbow Trout, we assessed size-dependent predation by Northern Pike on Rainbow Trout and determined the relative energetic contribution of stocked Rainbow Trout to Northern Pike growth using bioenergetics modeling. Stable isotopes combined with traditional diet analyses revealed that smaller Northern Pike (<600 mm TL) consumed primarily centrarchids and Rainbow Smelt Osmerus mordax, and Rainbow Trout contributed less than 10% to their annual energy consumption. In contrast, larger Northern Pike (≥600 mm TL) consumed primarily Rainbow Trout, which accounted for 56% of their annual energy consumption. Combining estimates of Northern Pike predation with production costs of catchable-size Rainbow Trout revealed that annual economic losses ranged from US$15,259 to $24,801 per year. Over its lifespan, an age-10 Northern Pike was estimated to consume ~117 Rainbow Trout worth approximately $340. Thus, Northern Pike predation substantially influences salmonid management initiatives and is likely a primary factor contributing to reduced Rainbow Trout abundance and return to anglers in Pactola Reservoir. Strategies for reducing Northern Pike predation on Rainbow Trout include increasing the size of stocked fish or altering the timing and spatial distribution of stocking events.

75 FR 27841 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-18

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR The ACRS Subcommittee on EPR will hold a meeting on May 21, 2010, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public attendance. The agenda for...

78 FR 65008 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Evolutionary...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-30

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Evolutionary Power Reactor; Notice of Meeting The ACRS Subcommittee on U.S. Evolutionary Power Reactor (U.S. EPR) will hold a meeting on November 6, 2013, Room T-2B1, 11545 Rockville Pike, Rockville...

75 FR 28075 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-19

... NUCLEAR REGULATORY COMMISSION [NRC-2010-0002] Sunshine Act Notice DATES: Weeks of May 17, 24, 31, June, 7, 14, 21, 2010. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland..., 2010. Week of May 24, 2010--Tentative Thursday, May 27, 2010 9:30 a.m. Briefing on the Results of the...

77 FR 28637 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-15

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on May 22- 23, 2012, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to...

77 FR 28903 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-16

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on May 22, 2012, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public...

77 FR 31676 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Fukushima; Notice of Meeting The ACRS Subcommittee on Fukushima will hold a meeting on June 20, 2012, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public...

76 FR 5220 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Future Plant...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-28

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Future Plant Designs The ACRS Subcommittee on Future Plant Designs will hold a meeting on February 9, 2011, at 11545 Rockville Pike, Room T-2B1, Rockville, Maryland. The entire meeting will be open...

76 FR 16016 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Future Plant...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-22

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Future Plant Designs The ACRS Subcommittee on Future Plant Designs will hold a meeting on April 5, 2011, at 11545 Rockville Pike, Room T-2B1, Rockville, Maryland. The entire meeting will be open...

10 CFR 63.4 - Communications and records.

Code of Federal Regulations, 2011 CFR

2011-01-01

... follows: (1) By mail addressed: ATTN: Document Control Desk; Director, Office of Nuclear Material Safety... the NRC's offices at 11555 Rockville Pike, Rockville, Maryland; ATTN: Document Control Desk: Director... obtained by visiting the NRC's Web site at http://www.nrc.gov/site-help/e-submittals.html; by e-mail to...

10 CFR 63.4 - Communications and records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... follows: (1) By mail addressed: ATTN: Document Control Desk; Director, Office of Nuclear Material Safety... the NRC's offices at 11555 Rockville Pike, Rockville, Maryland; ATTN: Document Control Desk: Director... obtained by visiting the NRC's Web site at http://www.nrc.gov/site-help/e-submittals.html; by e-mail to...

75 FR 15639 - Revision of the Requirements for Constituent Materials

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-30

... and Research (HFM-17), Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville, MD... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 610 [Docket No. FDA-2010-N-0099] RIN 0910-AG15 Revision of the Requirements for Constituent Materials AGENCY: Food and...

77 FR 64812 - National Institute of General Medical Sciences; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-23

... Hilton Bethesda, 8120 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Saraswathy Seetharam, Ph.D... Drive, Room 3An18K, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Brian R. Pike, Ph.D... Chemistry Research; 93.862, Genetics and Developmental Biology Research; 93.88, Minority Access to Research...

76 FR 10040 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-23

... Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852. (Telephone..., 6001 Executive Boulevard; MSC 9529, Neuroscience Center; Room 3203, Bethesda, MD 20892-9529. 301-496... Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852. (Telephone...

75 FR 20398 - The ACRS Subcommittee on Planning and Procedures will hold a meeting on May 5, 2010, in Room T...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-19

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Planning and Procedures The ACRS Subcommittee on Planning and Procedures will hold a meeting on May 5, 2010, in Room T-2B1, at 11545 Rockville Pike, Rockville, MD. The entire meeting will be open to...

77 FR 74696 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on AP-1000...

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2012-12-17

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on AP-1000; Notice of Meeting The ACRS Subcommittee on AP-1000 will hold a meeting on January 18, 2013, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public...

77 FR 67688 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital I&C...

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2012-11-13

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital I&C; Notice of Meeting The ACRS Subcommittee on Digital I&C will hold a meeting on November 16, 2012, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open...

78 FR 66968 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-07

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor; Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR) will hold a meeting on November 22, 2013, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The meeting will be...

77 FR 56240 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on US-APWR...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-12

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on US-APWR; Notice of Meeting The ACRS Subcommittee on US-APWR will hold a meeting on September 20, 2012, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public...

76 FR 63624 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-13

... Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call... Institute of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6151, MSC 9606, Bethesda..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person...

76 FR 28440 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-17

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person... Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda, MD..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person...

77 FR 64119 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-18

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person... Institute of Mental Health, NIH, Neuroscience Center/Room 6138/MSC 9608, 6001 Executive Boulevard, Bethesda... Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone...

77 FR 64527 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-22

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person... Institute of Mental Health, NIH, Neuroscience Center/Room 6138/MSC 9608, 6001 Executive Boulevard, Bethesda... Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone...

75 FR 18214 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person... Extramural Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda...: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852...

77 FR 10785 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-23

... Monday, October 17, 2011 (76 FR 64126-64127). Thursday, March 8, 2012, Conference Room T2-B1, 11545....: Selected Chapters of the Safety Evaluation Report (SER) with Open Items Associated with the US Evolutionary...)(4)] Friday, March 9, 2012, Conference Room T2-B1, 11545 Rockville Pike, Rockville, Maryland 8:30 a.m...

75 FR 15461 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-29

..., by telephone at 301- 415-6258, or by e-mail to INFOCOLLECTS.Resource@NRC.GOV . Dated at Rockville... free of charge at the NRC Public Document Room, One White Flint North, 11555 Rockville Pike, Room O-1.... Mail comments to NRC Clearance Officer, Tremaine Donnell (T-5 F53), U.S. Nuclear Regulatory Commission...

78 FR 17945 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Future Plant...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-25

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Future Plant Designs; Notice of Meeting The ACRS Subcommittee on Future Plant Designs will hold a meeting on April 9, 2013, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public attendance....

76 FR 64123 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Future Plant...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-17

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Future Plant Designs; Notice of Meeting The ACRS Subcommittee on Future Plant Designs will hold a meeting on November 2, 2011, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public...

77 FR 74698 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Future Plant...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-17

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Future Plant Designs; Notice of Meeting The ACRS Subcommittee on Future Plant Designs will hold a meeting on January 17, 2013, Room T-2B3, 11545 Rockville Pike, Rockville, Maryland. The meeting will be open to public attendance, wit...

78 FR 37595 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-21

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor; Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR) will hold a meeting on July 9, 2013, Room T-2B3, 11545 Rockville Pike, Rockville, Maryland. The meeting will be open to...

Pike Parvalbumin

NASA Technical Reports Server (NTRS)

1997-01-01

Parvalbumins are found in the muscles, endocrine glands, skin cells, and some neurons of vertebrates, but the role they play for musculature is not yet understood. Researchers are exploring theories of a correlation between parvalbumin concentration levels and the relaxation speed of mammalian muscles after contraction. An ultra-high resolution structure was achieved from samples grown on STS-83 and in July 1997, during STS-94, PCAM produced the largest crystals of pike parvalbumin grown to date. Principal Investigator: Dan Carter of New Century Pharmaceuticals.

Pikes Peak conceptual shuttle study : visitation trends and scenario planning

DOT National Transportation Integrated Search

2016-04-01

This study for the U.S. Forest Service provides a preliminary analysis and set of recommendations to support the agency's work moving forward to implement a shuttle system at Colorados popular Pikes Peak in Pike and San Isabel National Forests. Th...

76 FR 30404 - Advisory Committee On Reactor Safeguards; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-25

... Room T2-B1, 11545 Rockville Pike, Rockville, Maryland 8:30 a.m.-8:35 a.m.: Opening Remarks by the ACRS... Alloy Cladding.'' 10:45 a.m.-11:45 a.m.: Revised Safety Evaluation Report Associated with the License... to the safety evaluation report associated with the license renewal application for the Hope Creek...

75 FR 16203 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR; Notice...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-31

... hold a meeting on April 20-21, 2010, at 11545 Rockville Pike, T2- B1, Rockville, Maryland. The entire... review Chapters 4, 5 and 17 of the Safety Evaluation Report with Open Items associated with the staff's... a.m.-5 p.m. The Subcommittee will review Chapter 12 of the Safety Evaluation Report with Open Items...

10 CFR 73.4 - Communications.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., Washington, DC 20555-0001; (b) By hand delivery to the NRC's offices at 11555 Rockville Pike, Rockville...://www.nrc.gov/site-help/e-submittals.html; by e-mail to [email protected]; or by writing the Office... hand in accordance with this paragraph. [68 FR 58819, Oct. 10, 2003, as amended at 73 FR 5725, Jan. 31...

10 CFR 95.9 - Communications.

Code of Federal Regulations, 2010 CFR

2010-01-01

...-0001; (b) By hand delivery to the NRC's offices at 11555 Rockville Pike, Rockville, Maryland; or (c....gov/site-help/e-submittals.html; by e-mail to [email protected]; or by writing the Office of... 73 of this chapter or delivered by hand in accordance with § 95.39 of this chapter to the NRC...

75 FR 39056 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-07

... 301- 415-6258, or by e-mail to INFOCOLLECTS.Resource@NRC.GOV . Dated at Rockville, Maryland, this 28th... free of charge at the NRC Public Document Room, One White Flint North, 11555 Rockville Pike, Room O-1... comments: Go to http://www.regulations.gov and search for Docket No. NRC-2010-0233. Mail comments to NRC...

75 FR 20008 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

... 301- 415-6258, or by e-mail to INFOCOLLECTS.Resource@NRC.GOV . Dated at Rockville, Maryland, this 9th... be viewed free of charge at the NRC Public Document Room, One White Flint North, 11555 Rockville Pike... comments: Go to http://www.regulations.gov and search for Docket No. NRC-2010-0064. Mail comments to NRC...

78 FR 66029 - National Cancer Institute; Amended Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-04

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, October 09, 2013, 08:00 a.m. to October 10, 2013, 05:00 p.m., Hilton Washington/Rockville, 1750 Rockville Pike,...

78 FR 66374 - National Cancer Institute; Amended Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-05

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, October 15, 2013, 4:00 p.m. to October 16, 2013, 5:00 p.m., Hilton Washington/Rockville, 1750 Rockville Pike,...

78 FR 58322 - National Cancer Institute; Amended Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-23

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, November 06, 2013, 06:30 p.m. to November 07, 2013, 04:00 p.m., Hilton Washington/Rockville, 1750 Rockville Pike,...

Fishing for Northern Pike in Minnesota: A comparison of anglers and dark house spearers

USGS Publications Warehouse

Schroeder, Susan A.; Fulton, David C.

2014-01-01

In order to project fishing effort and demand of individuals targeting Northern Pike Esox lucius in Minnesota, it is important to understand the catch orientations, management preferences, and site choice preferences of those individuals. Northern Pike are specifically targeted by about 35% of the approximately 1.5 million licensed anglers in Minnesota and by approximately 14,000–15,000 dark house spearers. Dark house spearing is a traditional method of harvesting fish through the ice in winter. Mail surveys were distributed to three research strata: anglers targeting Northern Pike, dark house spearing license holders spearing Northern Pike, and dark house spearing license holders angling for Northern Pike. Dark house spearers, whether spearing or angling, reported a stronger orientation toward keeping Northern Pike than did anglers. Anglers reported a stronger orientation toward catching large Northern Pike than did dark house spearers when spearing or angling. Northern Pike regulations were the most important attribute affecting site choice for respondents in all three strata. Models for all strata indicated a preference for lakes without protected slot limits. However, protected slot limits had a stronger negative influence on lake preference for dark house spearing licensees (whether spearing or angling) than for anglers.

75 FR 9421 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person... Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Boulevard, Suite 3204, MSC 9529, Bethesda, MD.../Neuroscience Center, 6001 Executive Boulevard, Suite 3204, MSC 9529, Bethesda, MD 20892, (301) 496-0660...

The Bethesda System for Reporting Thyroid Cytopathology.

PubMed

Cibas, Edmund S; Ali, Syed Z

2009-11-01

To address terminology and other issues related to thyroid fine-needle aspiration (FNA), the National Cancer Institute (NCI) hosted The NCI Thyroid FNA State of the Science Conference. The conclusions regarding terminology and morphologic criteria from the NCI meeting led to the Bethesda Thyroid Atlas Project and form the framework for the Bethesda System for Reporting Thyroid Cytopathology. Participants of the Atlas Project were selected from among the committee members of the NCI FNA State of the Science Conference and other participants at the live conference. The terminology framework was based on a literature search of English language publications dating back to 1995 using PubMed as the search engine; online forum discussions ( http://thyroidfna.cancer.gov/forums/default.aspx ); and formal interdisciplinary discussions held on October 22 and 23, 2007, in Bethesda, MD. For clarity of communication, the Bethesda System for Reporting Thyroid Cytopathology recommends that each report begin with one of the six general diagnostic categories. Each of the categories has an implied cancer risk that links it to an appropriate clinical management guideline. The project participants hope that the adoption of this framework will facilitate communication among cytopathologists, endocrinologists, surgeons, and radiologists; facilitate cytologic-histologic correlation for thyroid diseases; facilitate research into the understanding of thyroid diseases; and allow easy and reliable sharing of data from different laboratories for national and international collaborative studies.

The northern pike, a prized native but disastrous invasive: Chapter 14

USGS Publications Warehouse

Rutz, David; Massengill, Robert L.; Sepulveda, Adam; Dunker, Kristine J.

2018-01-01

As the chapters in this book describe, the northern pike Esox lucius Linneaus, 1758 is a fascinating fish that plays an important ecological role in structuring aquatic communities (chapter 8), has the capacity to aid lake restoration efforts (chapter 11), and contributes substantially to local economies, both as a highlysought after sport fish (chapter 12) and as a commercial fishing resource (chapter 13). However, despite the magnificent attributes of this fish, there is another side to its story. Specifically, what happens when northern pike, a highly efficient predator, becomes established outside its natural range? To explore this question, this chapter will investigate observed consequences from many locations where northern pike (hereafter referred to as “pike”) have been introduced and discuss potential reasons why pike, under the right circumstances, can be considered an invasive species.

77 FR 9672 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-17

... Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6140, MSC 9608, Bethesda, MD 20892-9608, 301..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person... of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6151, MSC 9606, Bethesda, MD...

Vegetative substrates used by larval northern pike in Rainy and Kabetogama Lakes, Minnesota

Treesearch

Anne L. Timm; Rodney B. Pierce

2015-01-01

Our objective was to identify characteristics of aquatic vegetative communities used as larval northern pike nursery habitat in Rainy and Kabetogama lakes, glacial shield reservoirs in northern Minnesota. Quatrefoil light traps fished at night were used to sample larval northern pike in 11 potential nursery areas. Larval northern pike were most commonly sampled among...

Mechanical suppression of northern pike (Esox lucius) populations in small Arizona reservoirs

USGS Publications Warehouse

Kuzmenko, Yuliya; Spesiviy, Timofy; Bonar, Scott A.

2010-01-01

Introduced populations of northern pike Esox lucius have provided angling opportunities in the western United States (McMahon and Bennett 1996). However, the northern pike is a voracious piscivore and its large size, high fecundity, and broad physiological tolerance make it capable of drastically altering ecosystems it invades (Marchetti et al. 2004). Indeed, predation by northern pike has been shown to significantly alter fish community structure and put native fishes at a higher extinction risk (He and Kitchell 1990, Findlay et al. 2000). Predation by northern pike is viewed as a significant threat to native stocks of salmonids in Washington, British Columbia, and California (McMahon and Bennett 1996, California Department of Fish and Game [CDFG] 2003).

77 FR 57097 - Office of the Director, National Institutes of Health Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-17

... Pike, Rockville, MD 20852. Contact Person: Barbara J. Nelson, Ph.D., Scientific Review Officer, Office of Grants Management & Scientific Review, National Center for Advancing Translational, Sciences NCATS...

Core Values, Education and Research: A Response to Mark Pike

ERIC Educational Resources Information Center

Bragg, Sara; Allington, Daniel; Simmons, Katy; Jones, Ken

2011-01-01

This article presents the authors' response to the article by Mark Pike, which appeared in the "Oxford Review of Education" in December 2010. Pike's article focuses on Trinity Academy, one of four academies in the Emmanuel Schools Foundation (ESF): it is not a faith school, but sponsored by a Christian faith-based and business-oriented…

First detection of pike fry-like rhabdovirus in barbel and spring viraemia of carp virus in sturgeon and pike in aquaculture in the Czech Republic.

PubMed

Vicenova, Monika; Reschova, Stanislava; Pokorova, Dagmar; Hulova, Jana; Vesely, Tomas

2011-06-16

Rapid antigen detection enzyme-linked immunosorbent assay (ELISA) testing of cell cultures with organ homogenate from fish, collected from farms with a predominance of common carp or in natural aquaculture in the Czech Republic between 1995 and 2008, identified piscine vesiculovirus in 27 of 178 samples. Using reverse transcription semi-nested PCR, targeting a 550 nucleotide region of the glycoprotein (G) gene, piscine vesiculovirus was confirmed in 23 of the 27 organ samples diagnosed by ELISA as infected. PCR products were amplified and sequenced from 18 isolates from common carp Cyprinus carpio (family Cyprinidae), 2 isolates from northern pike Esox lucius (family Esocidae), and 1 isolate each from Siberian sturgeon Acipenser baerii (family Acipenseridae), common barbel Barbus barbus (family Cyprinidae), and koi carp Cyprinus carpio koi (family Cyprinidae). The sequences (based on 401 nucleotides) clustered into 2 genogroups. The majority of isolates (n = 22), including those from sturgeon and pike, grouped with the spring viraemia of carp virus (SVCV) Genogroup I and Subgroup Id. The 22 isolates could be further subdivided into 2 groups: Id1 (n = 20) and Id2 (n = 2). A marker (a non-conservative nucleotide substitution) for the Id1 SVCV group was identified. It was specifically found in all sequences of Id1 isolates when testing SVCV originating from different countries. The remaining isolate from barbel, was classified in the pike fry-like rhabdovirus Genogroup IV. This is the first confirmation of natural SVCV infection in sturgeon and pike, and pike fry-like rhabdovirus infection in barbel. In the case of the pike fry-like rhabdovirus, this is also its first identification in the Czech Republic. According to the presence/absence of evident clinical signs of rhabdoviral disease in the 3 infected hosts, only the sturgeon seemed to be susceptible to the monitored rhabdovirus.

77 FR 24972 - National Institute of Mental Health Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-26

..., Neuroscience Center, 6001 Executive Boulevard, Conference Room C/D/E, Rockville, MD 20852. Closed: 1:15 p.m. to..., Neuroscience Center, 6001 Executive Boulevard, Conference Room C/D/E, Rockville, MD 20852. Contact Person: Jane... Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6154, MSC 9609, Bethesda, MD 20892-9609, 301...

76 FR 51379 - National Institute of Mental Health Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-18

..., Neuroscience Center, 6001 Executive Boulevard, Conference Room C/D/E, Rockville, MD 20852. Closed: 1:30 p.m. to..., Neuroscience Center, 6001 Executive Boulevard, Conference Room C/D/E, Rockville, MD 20852. Contact Person: Jane..., NIH, Neuroscience Center, 6001 Executive Blvd., Room 6154, MSC 9609, Bethesda, MD 20892-9609, 301-443...

78 FR 52551 - National Institute of Mental Health; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-23

...), Neuroscience Center, 6001 Executive Boulevard, Conference Room C/D/E, Rockville, MD 20852. Closed: 2:30 p.m. to..., Neuroscience Center, 6001 Executive Boulevard, Conference Room C/D/E, Rockville, MD 20852. Contact Person: Jane... Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6154, MSC 9609, Bethesda, MD 20892-9609, 301...

77 FR 48998 - National Institute of Mental Health; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-15

... Neuroscience Center, 6001 Executive Boulevard, Conference Room C/D/E, Rockville, MD 20852. Closed: 2:30 p.m. to... Neuroscience Center, 6001 Executive Boulevard, Conference Room C/D/E, Rockville, MD 20852. Contact Person: Jane... Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6154, MSC 9609, Bethesda, MD 20892-9609, 301...

Growth, condition, diet, and consumption rates of northern pike in three Arizona reservoirs

USGS Publications Warehouse

Flinders, J.M.; Bonar, Scott A.

2008-01-01

Northern pike (Esox lucius L.) introductions are controversial in the western United States due to suspected impacts they might have on established sport fisheries and potential illegal introductions. Tbree Arizona reservoirs, Parker Canyon Lake, Upper Lake Mary and Long Lake were sampled to examine the diet, consumption dynamics, and growth of northern pike. Northern pike diets varied by season and reservoir. In Parker Canyon Lake, diets were dominated by rainbow trout in winter and spring and bluegill and green sunfish in the fall. In Long Lake the northern pike ate crayfish in spring and early summer and switched to young of the year common carp in summer and fall. Black crappie, golden shiners, and crayfish were the major prey in Upper Lake Mary during spring, but they switched to stocked rainbow trout in the fall. Northern pike growth was in the high range of growth reported throughout the United States. Estimated northern pike specific consumption rate (scr) of rainbow trout (g/g/d ?? 10-6) was greatest in Upper Lake Mary (scr = 329.1 ?? 23.7 g/g/d ?? 10-6) where stocked fingerling (280 mm TL) rainbow trout stocked in Long Lake (scr = 1.4 ?? 0.1 g/g/d ?? 10-6) and Parker Canyon Lake (scr = 287.2 ?? 15.1 g/g/d ?? 10-6) where catchable-sized rainbow trout were stocked. Managers should consider the cost-benefits of stocking fish >200 mm TL in lakes containing northern pike. ?? Copyright by the North American Lake Management Society 2008.

Biomarkers of contaminant exposure in northern pike (Esox lucius) from the Yukon River Basin, Alaska

USGS Publications Warehouse

Hinck, J.E.; Blazer, V.S.; Denslow, N.D.; Myers, M.S.; Gross, T.S.; Tillitt, D.E.

2007-01-01

As part of a larger investigation, northern pike (n = 158; Esox lucius) were collected from ten sites in the Yukon River Basin (YRB), Alaska, to document biomarkers and their correlations with organochlorine pesticide (total p,p'-DDT, total chlordane, dieldrin, and toxaphene), total polychlorinated biphenyls (PCBs), and elemental contaminant (arsenic, cadmium, copper, lead, total mercury, selenium, and zinc) concentrations. A suite of biomarkers including somatic indices, hepatic 7-ethoxyresorufin O-deethylase (EROD) activity, vitellogenin concentrations, steroid hormone (17B- ustradiol and 16-kebtestosteront) concentrations, splenic macrophage aggregates (MAs), oocyte atresia, and other microscopic anomalies in various tissues were documented in YRB pike. Mean condition factor (0.50 to 0.68), hepatosomatic index (1.00% to 3.56%), and splenosomatic index (0.09% to 0.18%) were not anomalous at any site nor correlated with any contaminant concentration. Mean EROD activity (0.71 to 17.51 pmol/min/mg protein) was similar to basal activity levels previously measured in pike and was positively correlated with selenium concentrations (r = 0.88, P < 0.01). Vitellogenin concentrations in female (0.09 to 5.32 mg/mL) and male (0.01 mg/mL in male pike from multiple sites indicated exposure to estrogenic compounds. Mean steroid hormone concentrations and percent oocyte atresia were not anomalous in pike from any YRB site. Few site differences were significant for mean MA density (1.86 to 6.42 MA/mm2), size (812 to 1481 ??m2), and tissue occupied (MA-%; 0.24% to 0.75%). A linear regression between MA-% and total PCBs was significant, although PCB concentrations were generally low in YRB pike (???63 ng/g), and MA-% values in female pike (0.24% to 0.54%) were lower than in male pike (0.32% to 0.75%) at similar PCB concentrations. Greater numbers of MAs were found as zinc concentrations increased in YRB female pike, but it is unlikely that this is a causative relationship

AQCESS (Automated Quality of Care Evaluation Support System) Ad Hoc Report Generator Quick Reference Guide.

DTIC Science & Technology

1986-06-01

GUIDE JJ TRIMIS Program Office 5401 Westbard Avenue Bethesda, Maryland 20816 W" V NDC Federal Systems. lnc.._" 1300 Piccard Drive .. -Rockville, Marylcn...Project/Teay iUnft1. DOD A A fri-Service Medical Information Systems Program office 11. Contract(C) orGaw a 5401 Westbard Avenue (C) Bethesda, MD 20816

Installation Restoration Program. Preliminary Assessment: 183rd Tactical Fighter Group, Illinois Air National Guard, Capital Airport, Springfield, Illinois

DTIC Science & Technology

1990-05-01

11140 Rockville Pike Rockville, Maryland 20852 Contract No. DLA 900-82-C-4426 Completed by Science & Technology, Inc. 704 South Illinois Avenue Suite C... Environments . .......... 111-19 IV. SITE EVALUATION...................v-i *A. Activity Review ................. v-i B. Disposal/Spill Site Identification...approximately 120 feet north of a small pond and creek located on the south side of the airport on airport property. The Base conducted operations at

Trophic ecology of northern pike and their effect on conservation of westslope cutthroat trout.

USGS Publications Warehouse

Walrath, John D.; Quist, Michael C.; Firehammer, Jon A.

2015-01-01

Westslope Cutthroat Trout Oncorhynchus clarkii lewisi in Coeur d’Alene Lake, Idaho, have declined in recent years; predation by Northern Pike Esox lucius, a nonnative sport fish, is thought to be a causative mechanism. The goal of this study was to describe the seasonal food habits of Northern Pike and determine their influence on Westslope Cutthroat Trout in Coeur d’Alene Lake by using a bioenergetics modeling approach. Fish were sampled monthly from March 2012 to May 2013 using pulsed-DC electrofishing and experimental gillnetting in four bays. Northern Pike catch rates from electrofishing were generally low but increased slightly each season and were highest in the southern portion of the lake; catch rates from gillnetting were approximately 50% higher during the two spring sampling periods compared with the summer and fall. Seasonal growth and food habits of 695 Northern Pike (TL = 16.2–108.0 cm; weight = 24–9,628 g) were analyzed. Diets primarily consisted of kokanee O. nerka, Westslope Cutthroat Trout, and Yellow PerchPerca flavescens. Results of a bioenergetics model estimated that Westslope Cutthroat Trout represented approximately 2–30% of the biomass consumed by age-1–4 Northern Pike. Total Westslope Cutthroat Trout biomass consumed by Northern Pike (2008–2011 year-classes) across all seasons sampled was estimated to be 1,231 kg (95% CI = 723–2,396 kg), and the total number consumed was 5,641 (95% CI = 3,311–10,979). The highest occurrence of Westslope Cutthroat Trout in Northern Pike diets was observed during spring. Thus, reducing Northern Pike predation on Westslope Cutthroat Trout would be one tool worth considering for conserving Westslope Cutthroat Trout populations in Coeur d’Alene Lake.

Pike International, LLC et al. Information Sheet

EPA Pesticide Factsheets

Pike International LLC, et al. (the Company) is located in New Haven, Connecticut. The Complaint involves the lease of, and renovation activities conducted at, property constructed prior to 1978, located in New Haven, Connecticut.

76 FR 22935 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on U.S...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-25

... Power Reactor (U.S. EPR) will hold a meeting on May 11, 2011, Room T-2B1, 11545 Rockville Pike.... EPR Design Control Document (DCD). The Subcommittee will hear presentations by and hold discussions...

Population structure and dynamics of northern pike and smallmouth bass in Coeur d’Alene Lake, Idaho.

USGS Publications Warehouse

Walrath, John D.; Quist, Michael C.; Firehammer, Jon A.

2015-01-01

Numerous species have been introduced to Coeur d'Alene Lake, Idaho over the last century, but minimal research has been completed to understand their population dynamics. The objective of this study was to describe the population demographics and dynamics of northern pike (Esox lucius) and smallmouth bass (Micropterus dolomieu), two important nonnative sport fishes in the system to provide information that will assist with guiding management decisions. The oldest northern pike was age 7 and the oldest smallmouth bass was age 11. Populations of both species exhibited very stable recruitment with a recruitment coefficient of determination of 0.99 for northern pike and 0.98 for smallmouth bass. Total annual mortality was estimated as 66% for northern pike and 42% for smallmouth bass. Growth of northern pike in Coeur d'Alene Lake was comparable to the 50–75th percentiles of growth exhibited by lentic northern pike populations across North America. Northern pike in Coeur d'Alene Lake were most similar to populations in the north-central and northeast United States with fast growth rates and short life spans. In contrast, smallmouth bass grew slowly and generally fell within the 5th percentile of lentic smallmouth bass populations in North America. Smallmouth bass in Coeur d'Alene Lake were similar to other populations in northern regions of the United States displaying slow growth rates with high longevity. Results of this study provide important insight on nonnative northern pike and smallmouth bass population dynamics.

METHYLMERCURY BIOACCUMULATION DEPENDENCE ON NORTHERN PIKE AGE AND SIZE IN TWENTY MINNESOTA LAKES

EPA Science Inventory

Mercury accumulation in northern pike muscle tissue (fillets) was found to be directly related to fish age and size. Measurements were made on 173 individual northern pike specimens from twenty lakes across Minnesota. Best fit regressions of mercury fillet concentration (wet wt.)...

Residue depletion of oxytetracycline from fillet tissues of northern pike and walleye

USGS Publications Warehouse

Bernardy, Jeffry A.; Vue, Chue; Gaikowski, Mark P.; Stehly, Guy R.; Gingerich, William H.; Moore, Allen

2003-01-01

The broad-spectrum antibacterial drug oxytetracycline (OTC) is used in the U.S. to treat certain diseases in salmonids and catfish. This study was conducted to support an extension of the OTC label to include all cool-water fish species cultured at U.S. public aquaculture facilities by satisfying human food safety requirements. Juvenile northern pike (Esox lucius; mean weight: 117 g) and walleye (Stizostedion vitreum; mean weight: 59 g) were fed OTC-medicated diets near the maximum legal treatment rate (82.7 mg OTC-HCl/kg fish/day for 10 days) and near the lower limit of the water temperature range for most disease outbreaks in these species (14 and 16 °C, respectively). Two trials were conducted simultaneously with northern pike, one using commercially medicated feed and the other using on-site OTC top-coated feed. A third trial was performed with walleye using on-site OTC top-coated feed. Fillet tissues were collected and OTC free base (OTC-base) concentrations were determined by high performance liquid chromatography. The maximum mean OTC-base concentrations in the fillet tissue were 319 ng/g in northern pike (skinless) and 721 ng/g in walleye (skin-on), both well below the current tolerance limit of 2000 ng/g OTC-base. The log-linear loss of OTC-base from the fillet tissues was monophasic, with terminal phase half-lives of 5.9 days in northern pike fed commercial medicated feed, 6.7 days in northern pike fed top-coated feed, and 10.5 days in walleye fed top-coated feed. The data supported a zero withdrawal time in juvenile northern pike and walleye fed OTC at the approved dose level for 10 days at water temperatures down to 14 and 16 °C respectively.

Meibomianitis

MedlinePlus

... less oil being made for the normal tear film. These people often have symptoms of dry eye. ... Guidelines Viewers & Players MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, ...

X-ray

MedlinePlus

... The images are recorded on a computer or film. Structures that are dense (such as bone) will ... Guidelines Viewers & Players MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, ...

Retrograde cystography

MedlinePlus

... of computed tomography, magnetic resonance imaging, and plain film. In: Wein AJ, Kavoussi LR, Partin AW, Peters ... Guidelines Viewers & Players MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, ...

Blocked tear duct

MedlinePlus

... may be closed or covered by a thin film, which causes a partial blockage. In adults, the ... Guidelines Viewers & Players MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, ...

Venogram - leg

MedlinePlus

... through the body to form an image on film. Structures that are dense (such as bone) will ... Guidelines Viewers & Players MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, ...

Extremity x-ray

MedlinePlus

... through the body to form an image on film. Structures that are dense (such as bone) will ... Guidelines Viewers & Players MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, ...

Abdominal x-ray

MedlinePlus

... are, or may be, pregnant. Alternative Names Abdominal film; X-ray - abdomen; Flat plate; KUB x-ray ... Guidelines Viewers & Players MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, ...

X-ray - skeleton

MedlinePlus

... pass through the body. A computer or special film records the images. Structures that are dense (such ... Guidelines Viewers & Players MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, ...

Patient Workload Profile: National Naval Medical Center (NNMC), Bethesda, MD.

DTIC Science & Technology

1980-06-01

Diets Sucrose-Fructose Elimination Diet Medium-Chain Triglyceride (MCT) Barium Enema Preparation Diet Ketogenic Diet 125 mg Calcium Test Diet ...Traditional Ketogenic Diet 150 gm and 300 gm Carbohydrate Sodium Restricted Diets Test Diets Sodium Restricted, Calorie Restricted Fat Free Test Diet Diets 100...Rations Served - NNMC, Bethesda 89 7-2 Regular and Therapeutic Diets - NNMC, Bethesda 91 7-3 Regular and Therapeutic Rations Served

Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability

PubMed Central

Umar, Asad; Boland, C. Richard; Terdiman, Jonathan P.; Syngal, Sapna; de la Chapelle, Albert; Rüschoff, Josef; Fishel, Richard; Lindor, Noralane M.; Burgart, Lawrence J.; Hamelin, Richard; Hamilton, Stanley R.; Hiatt, Robert A.; Jass, Jeremy; Lindblom, Annika; Lynch, Henry T.; Peltomaki, Païvi; Ramsey, Scott D.; Rodriguez-Bigas, Miguel A.; Vasen, Hans F. A.; Hawk, Ernest T.; Barrett, J. Carl; Freedman, Andrew N.; Srivastava, Sudhir

2010-01-01

Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, neoplastic lesions, and microsatellite instability (MSI). Because cancers with MSI account for approximately 15% of all colorectal cancers and because of the need for a better understanding of the clinical and histologic manifestations of HNPCC, the National Cancer Institute hosted an international workshop on HNPCC in 1996, which led to the development of the Bethesda Guidelines for the identification of individuals with HNPCC who should be tested for MSI. To consider revision and improvement of the Bethesda Guidelines, another HNPCC workshop was held at the National Cancer Institute in Bethesda, MD, in 2002. In this commentary, we summarize the Workshop presentations on HNPCC and MSI testing; present the issues relating to the performance, sensitivity, and specificity of the Bethesda Guidelines; outline the revised Bethesda Guidelines for identifying individuals at risk for HNPCC; and recommend criteria for MSI testing. PMID:14970275

Trophic ecology of largemouth bass and northern pike in allopatric and sympatric assemblages in northern boreal lakes

USGS Publications Warehouse

Soupir, Craig A.; Brown, Michael L.; Kallemeyn, Larry W.

2000-01-01

Largemouth bass (Micropterus salmoides) and northern pike (Esox lucius) are top predators in the food chain in most aquatic environments that they occupy; however, limited information exists on species interactions in the northern reaches of largemouth bass distribution. We investigated the seasonal food habits of allopatric and sympatric assemblages of largemouth bass and northern pike in six interior lakes within Voyageurs National Park, Minnesota. Percentages of empty stomachs were variable for largemouth bass (38-54%) and northern pike (34.7-66.7%). Fishes (mainly yellow perch, Perca flavescens) comprised greater than 60% (mean percent mass, MPM) of the northern pike diet during all seasons in both allopatric and sympatric assemblages. Aquatic insects (primarily Odonata and Hemiptera) were important in the diets of largemouth bass in all communities (0.0-79.7 MPM). Although largemouth bass were observed in the diet of northern pike, largemouth bass apparently did not prey on northern pike. Seasonal differences were observed in the proportion of aquatic insects (P = 0.010) and fishes (P = 0.023) in the diets of northern pike and largemouth bass. Based on three food categories, jackknifed classifications correctly classified 77 and 92% of northern pike and largemouth bass values, respectively. Percent resource overlap values were biologically significant (greater than 60%) during at least one season in each sympatric assemblage, suggesting some diet overlap.

Bethesda 2014: improving on a paradigm shift.

PubMed

Wilbur, D C; Nayar, R

2015-12-01

The third iteration of the Bethesda System terminology manual was recently published. This update included changes in the reporting of benign endometrial cells, and guidance for special adequacy situations and for cases in which low grade squamous intraepithelial lesions are accompanied by some cells suggesting that a high grade lesion might also be present. In addition, the manual was increased in size to include more illustrations with special studies and comparisons to histology, a greatly increased reference list, and a new chapter devoted to the modern practice of risk-based management. The third edition of the Bethesda manual is meant to serve as a primary reference for the practice of gynecologic cytology designed to provide a uniform system of reporting Worldwide for clinical, teaching, and research purposes. © 2015 John Wiley & Sons Ltd.

Use of electronarcosis to immobilize juvenile and adult northern pike

USGS Publications Warehouse

Walker, M.K.; Yanke, E.A.; Gingerich, W.H.

1994-01-01

Electronarcosis, the immobilization of a fish after an electric current has been applied and discontinued, is a potential alternative to chemical anesthetics. Successful narcosis was defined as the immobilization of a fish for 1-15 min without causing physical damage. In the laboratory, AC successfully narcotized juvenile (13-19-cm standard length, SL) northern pike (Esox lucius) at selected voltages; however, AC voltages that produced narcosis or resulted in physical damage were variable and unpredictable. In contrast, 60-90-V pulsed DC (PDC) for 10-60 s successfully narcotized juvenile pike without inducing physical damage. Duration of narcosis was directly related to voltage and inversely related to fish length. In the hatchery, sexually mature northern pike (45-97 cm SL), collected from the Mississippi River, were successfully narcotized by 60-V PDC for 10 s. Duration of narcosis was unrelated to fish length or sex, and averaged 58 plus or minus 7 s (mean plus or minus SE). This allowed sufficient time to collect eggs or milt. All fish were swimming upright within 3 min after treatment, and no mortalities were observed over the next 24 h. Survival of eggs from fertilization to eye- up did not significantly differ between eggs collected from electronarcotized adults and adults anesthetized with MS-222 (tricaine methanesulfonate). Electronarcosis represents a possible alternative to chemical anesthetics for immobilizing northern pike broodstock without an apparent impact on egg survival.

77 FR 18248 - Meeting of the Advisory Committee on Minority Health

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

..., Bethesda, Maryland 20814. FOR FURTHER INFORMATION CONTACT: Ms. Monica A. Baltimore, Tower Building, 1101... Executive Director, ACMH, Tower Building, 1101 Wootton Parkway, Suite 600, Rockville, Maryland 20852, prior...

Comparing catch orientation among Minnesota walleye, northern pike, and bass anglers

USGS Publications Warehouse

Schroeder, Susan A.; Fulton, David C.

2013-01-01

We compared the catch orientations of Minnesota walleye (Sander vitreus), northern pike (Esox lucius), largemouth bass (Micropterus salmoides), and smallmouth bass (Micropterus dolomieu) anglers. Results were derived from 2009, 2010, and 2012 surveys of anglers targeting these different species. Consistent with previous research, we identified four dimensions of anglers’ catch orientation: (a) catching something, (b) catching big fish, (c) catching many fish, and (d) keeping fish. Walleye anglers were the most motivated to keep fish, while northern pike anglers were more oriented toward catching big fish. Largemouth bass anglers, and to a lesser extent smallmouth bass anglers, were also oriented toward catching big fish. Bass anglers reported the lowest interest in keeping fish. An orientation to keep fish was negatively related to more restrictive management actions, regardless of species. A stronger orientation to catch big fish was associated with support for increased harvest restrictions only for northern pike and smallmouth bass.

Residue depletion of oxytetracycline from fillet tissues of northern pike and walleye

USGS Publications Warehouse

Bernardy, J.A.; Vue, C.; Gaikowski, M.P.; Stehly, G.R.; Gingerich, W.H.; Moore, A.

2003-01-01

Iowa Department of Natural Resources Fisheries Bureau,Rathbun Research,15053 Hatchery Place,Moravia, IA 52571-8933,USA The broad-spectrum antibacterial drug oxytetracycline (OTC) is used in the U.S. to treat certain diseases in salmonids and catfish. This study was conducted to support an extension of the OTC label to include all cool-water fish species cultured at U.S. public aquaculture facilities by satisfying human food safety requirements. Juvenile northern pike (Esox lucius; mean weight: 117 g) and walleye (Stizostedion vitreum; mean weight: 59 g) were fed OTC-medicated diets near the maximum legal treatment rate (82.7 mg OTC-HCl/kg fish/day for 10 days) and near the lower limit of the water temperature range for most disease outbreaks in these species (14 and 16??C, respectively). Two trials were conducted simultaneously with northern pike, one using commercially medicated feed and the other using on-site OTC top-coated feed. A third trial was performed with walleye using on-site OTC top-coated feed. Fillet tissues were collected and OTC free base (OTC-base) concentrations were determined by high performance liquid chromatography. The maximum mean OTC-base concentrations in the fillet tissue were 319 ng/g in northern pike (skinless) and 721 ng/g in walleye (skin-on), both well below the current tolerance limit of 2000 ng/g OTC-base. The log-linear loss of OTC-base from the fillet tissues was monophasic, with terminal phase half-lives of 5.9 days in northern pike fed commercial medicated feed, 6.7 days in northern pike fed top-coated feed, and 10.5 days in walleye fed top-coated feed. The data supported a zero withdrawal time in juvenile northern pike and walleye fed OTC at the approved dose level for 10 days at water temperatures down to 14 and 16??C respectively. Published by Elsevier Science B.V.

The Bethesda System For Reporting Thyroid Cytopathology.

PubMed

Cibas, Edmund S; Ali, Syed Z

2009-11-01

To address terminology and other issues related to thyroid fine-needle aspiration (FNA), the National Cancer Institute (NCI) hosted the NCI Thyroid FNA State of the Science Conference. The conclusions regarding terminology and morphologic criteria from the NCI meeting led to the Bethesda Thyroid Atlas Project and form the framework for The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). For clarity of communication, TBSRTC recommends that each report begin with 1 of 6 general diagnostic categories. The project participants hope that the adoption of this flexible framework will facilitate communication among cytopathologists, endocrinologists, surgeons, radiologists, and other health care providers; facilitate cytologic-histologic correlation for thyroid diseases; facilitate research into the epidemiology, molecular biology, pathology, and diagnosis of thyroid diseases; and allow easy and reliable sharing of data from different laboratories for national and international collaborative studies.

77 FR 15112 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-14

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person... Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda, MD... [[Page 15113

75 FR 19979 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person.../Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda, MD 20892-9529, 301-496-5324... [[Page 19980

Potential of environmental DNA to evaluate Northern pike (Esox lucius) eradication efforts: An experimental test and case study

USGS Publications Warehouse

Dunker, Kristine J.; Sepulveda, Adam; Massengill, Robert L.; Olsen, Jeffrey B.; Russ, Ora L.; Wenburg, John K.; Antonovich, Anton

2016-01-01

Determining the success of invasive species eradication efforts is challenging because populations at very low abundance are difficult to detect. Environmental DNA (eDNA) sampling has recently emerged as a powerful tool for detecting rare aquatic animals; however, detectable fragments of DNA can persist over time despite absence of the targeted taxa and can therefore complicate eDNA sampling after an eradication event. This complication is a large concern for fish eradication efforts in lakes since killed fish can sink to the bottom and slowly decay. DNA released from these carcasses may remain detectable for long periods. Here, we evaluated the efficacy of eDNA sampling to detect invasive Northern pike (Esox lucius) following piscicide eradication efforts in southcentral Alaskan lakes. We used field observations and experiments to test the sensitivity of our Northern pike eDNA assay and to evaluate the persistence of detectable DNA emitted from Northern pike carcasses. We then used eDNA sampling and traditional sampling (i.e., gillnets) to test for presence of Northern pike in four lakes subjected to a piscicide-treatment designed to eradicate this species. We found that our assay could detect an abundant, free-roaming population of Northern pike and could also detect low-densities of Northern pike held in cages. For these caged Northern pike, probability of detection decreased with distance from the cage. We then stocked three lakes with Northern pike carcasses and collected eDNA samples 7, 35 and 70 days post-stocking. We detected DNA at 7 and 35 days, but not at 70 days. Finally, we collected eDNA samples ~ 230 days after four lakes were subjected to piscicide-treatments and detected Northern pike DNA in 3 of 179 samples, with a single detection at each of three lakes, though we did not catch any Northern pike in gillnets. Taken together, we found that eDNA can help to inform eradication efforts if used in conjunction with multiple lines of inquiry and sampling

Potential of Environmental DNA to Evaluate Northern Pike (Esox lucius) Eradication Efforts: An Experimental Test and Case Study

PubMed Central

Dunker, Kristine J.; Sepulveda, Adam J.; Massengill, Robert L.; Olsen, Jeffrey B.; Russ, Ora L.; Wenburg, John K.; Antonovich, Anton

2016-01-01

Determining the success of invasive species eradication efforts is challenging because populations at very low abundance are difficult to detect. Environmental DNA (eDNA) sampling has recently emerged as a powerful tool for detecting rare aquatic animals; however, detectable fragments of DNA can persist over time despite absence of the targeted taxa and can therefore complicate eDNA sampling after an eradication event. This complication is a large concern for fish eradication efforts in lakes since killed fish can sink to the bottom and slowly decay. DNA released from these carcasses may remain detectable for long periods. Here, we evaluated the efficacy of eDNA sampling to detect invasive Northern pike (Esox lucius) following piscicide eradication efforts in southcentral Alaskan lakes. We used field observations and experiments to test the sensitivity of our Northern pike eDNA assay and to evaluate the persistence of detectable DNA emitted from Northern pike carcasses. We then used eDNA sampling and traditional sampling (i.e., gillnets) to test for presence of Northern pike in four lakes subjected to a piscicide-treatment designed to eradicate this species. We found that our assay could detect an abundant, free-roaming population of Northern pike and could also detect low-densities of Northern pike held in cages. For these caged Northern pike, probability of detection decreased with distance from the cage. We then stocked three lakes with Northern pike carcasses and collected eDNA samples 7, 35 and 70 days post-stocking. We detected DNA at 7 and 35 days, but not at 70 days. Finally, we collected eDNA samples ~ 230 days after four lakes were subjected to piscicide-treatments and detected Northern pike DNA in 3 of 179 samples, with a single detection at each of three lakes, though we did not catch any Northern pike in gillnets. Taken together, we found that eDNA can help to inform eradication efforts if used in conjunction with multiple lines of inquiry and sampling

Potential of Environmental DNA to Evaluate Northern Pike (Esox lucius) Eradication Efforts: An Experimental Test and Case Study.

PubMed

Dunker, Kristine J; Sepulveda, Adam J; Massengill, Robert L; Olsen, Jeffrey B; Russ, Ora L; Wenburg, John K; Antonovich, Anton

2016-01-01

Determining the success of invasive species eradication efforts is challenging because populations at very low abundance are difficult to detect. Environmental DNA (eDNA) sampling has recently emerged as a powerful tool for detecting rare aquatic animals; however, detectable fragments of DNA can persist over time despite absence of the targeted taxa and can therefore complicate eDNA sampling after an eradication event. This complication is a large concern for fish eradication efforts in lakes since killed fish can sink to the bottom and slowly decay. DNA released from these carcasses may remain detectable for long periods. Here, we evaluated the efficacy of eDNA sampling to detect invasive Northern pike (Esox lucius) following piscicide eradication efforts in southcentral Alaskan lakes. We used field observations and experiments to test the sensitivity of our Northern pike eDNA assay and to evaluate the persistence of detectable DNA emitted from Northern pike carcasses. We then used eDNA sampling and traditional sampling (i.e., gillnets) to test for presence of Northern pike in four lakes subjected to a piscicide-treatment designed to eradicate this species. We found that our assay could detect an abundant, free-roaming population of Northern pike and could also detect low-densities of Northern pike held in cages. For these caged Northern pike, probability of detection decreased with distance from the cage. We then stocked three lakes with Northern pike carcasses and collected eDNA samples 7, 35 and 70 days post-stocking. We detected DNA at 7 and 35 days, but not at 70 days. Finally, we collected eDNA samples ~ 230 days after four lakes were subjected to piscicide-treatments and detected Northern pike DNA in 3 of 179 samples, with a single detection at each of three lakes, though we did not catch any Northern pike in gillnets. Taken together, we found that eDNA can help to inform eradication efforts if used in conjunction with multiple lines of inquiry and sampling

Evaluation of the Tri-Service Radiology System at the Naval Hospital, Bethesda.

DTIC Science & Technology

1983-02-11

02140 Prepared for ’TRMS Program Office 5401 Westbard Avenue Bethesda, Maryland 20816 DTIC February 11, 1983 ELECTE ~M AY 311 9 3J ADL Reference 86292B...TROI^IMGOPI AND ADRESS ORT OATZTRDIIS Program Office February 11, 1983 5401 Westbard Avenue 13. NUME A O .F GsBethesda, Maryland 20816 220 1. MONITORINO

76 FR 63308 - Data and Data Needs To Advance Risk Assessment for Emerging Infectious Diseases Relevant to Blood...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-12

... Biologics Evaluation and Research (HFM-210), Food and Drug Administration, 1401 Rockville Pike, Suite 200N... Person) at least 7 days in advance. SUPPLEMENTARY INFORMATION: Quantitative risk assessments (QRAs) are... and maintaining critical relationships both within the Center for Biologics Evaluation and Research...

75 FR 16353 - Revision of Organization and Conforming Changes to Regulations

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2010-04-01

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Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-23

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76 FR 71124 - Caddo Valley Railroad Company-Abandonment Exemption-in Pike and Clark Counties, AR

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. AB 1076 (Sub-No. 1X)] Caddo Valley Railroad Company--Abandonment Exemption--in Pike and Clark Counties, AR On October 27, 2011, Caddo... 17.55 miles, in Pike and Clark Counties, Ark. (the line).\\1\\ The line traverses United States Postal...

Diagnostic accuracy of circulating thyrotropin receptor messenger RNA combined with neck ultrasonography in patients with Bethesda III-V thyroid cytology.

PubMed

Aliyev, Altay; Patel, Jinesh; Brainard, Jennifer; Gupta, Manjula; Nasr, Christian; Hatipoglu, Betul; Siperstein, Allan; Berber, Eren

2016-01-01

The aim of this study was to analyze the usefulness of thyrotropin receptor messenger RNA (TSHR-mRNA) combined with neck ultrasonography (US) in the management of thyroid nodules with Bethesda III-V cytology. Cytology slides of patients with a preoperative fine needle aspiration (FNA) and TSHR-mRNA who underwent thyroidectomy between 2002 and 2011 were recategorized based on the Bethesda classification. Results of thyroid FNA, TSHR-mRNA, and US were compared with the final pathology. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. There were 12 patients with Bethesda III, 112 with Bethesda IV, and 58 with Bethesda V cytology. The sensitivity of TSHR-mRNA in predicting cancer was 33%, 65%, and 79 %, and specificity was 67%, 66%, and 71%, for Bethesda III, IV, and V categories, respectively. For the same categories, the PPV of TSHR-mRNA was 25%, 33%, and 79%, respectively; whereas the NPV was 75%, 88%, and 71%, respectively. The addition of neck US to TSHR-mRNA increased the NPV to 100% for Bethesda III, and 86%, for Bethesda IV, and 82% for Bethesda V disease. This study documents the potential usefulness of TSHR-mRNA for thyroid nodules with Bethesda III-V FNA categories. TSHR-mRNA may be used to exclude Bethesda IV disease. A large sample analysis is needed to determine its accuracy for Bethesda category III nodules. Copyright © 2016 Elsevier Inc. All rights reserved.

78 FR 3474 - Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Materials...

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2013-01-16

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels will hold a meeting on February 6, 2013, Room T-2B1, 11545 Rockville Pike...

76 FR 72451 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Materials...

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2011-11-23

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels will hold a meeting on December 15, 2011, Room T-2B1, 11545 Rockville Pike...

77 FR 76089 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced...

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2012-12-26

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor; Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR) will hold a meeting on January 16, 2013, Room T-2B3, 11545 Rockville Pike...

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77 FR 74698 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Materials...

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2012-12-17

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels will hold a meeting on January 16, 2013, Room T-2B3, 11545 Rockville Pike...

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... Subcommittee on Materials, Metallurgy & Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels will hold a meeting on January 14, 2014, Room T-2B1, 11545 Rockville Pike... NRC's research activities in materials and metallurgy. The Subcommittee will hear presentations by and...

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... NUCLEAR REGULATORY COMMISSION Advisory Committee On Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels will hold a meeting on September 19, 2013, Room T-2B3, 11545 Rockville Pike...

78 FR 79019 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Materials...

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... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels will hold a meeting on January 14, 2014, Room T-2B1, 11545 Rockville Pike...

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... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy & Reactor Fuels will hold a meeting on December 4, 2013, Room T-2B1, 11545 Rockville Pike...

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2011-11-07

... provides recommendations for the design of clinical trials for cancer vaccines conducted under an IND to... in this notice finalizes the draft guidance of the same title dated September 2009. DATES: Submit...), Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, 1401 Rockville Pike...

76 FR 78672 - National Library of Medicine; Notice of Meetings

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2011-12-19

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... titles to be indexed by the National Library of Medicine and the discussions would likely to...: Administrative. Place: National Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike...

76 FR 16016 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of The ACRS Subcommittee on Materials...

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2011-03-22

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of The ACRS Subcommittee on Materials, Metallurgy And Reactor Fuels; Notice of Meeting The ACRS Subcommittee on Materials, Metallurgy and Reactor Fuels will hold a meeting on April 6, 2011, Room T-2B3, 11545 Rockville Pike...

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2011-06-21

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Radiation Protection and Nuclear Materials Notice of Meeting The ACRS Subcommittee on Radiation Protection and Nuclear Materials will hold a meeting on June 20, 2011, Room T-2B1, 11545 Rockville Pike...

76 FR 55717 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Reliability...

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... Subcommittee on Reliability and Probabilistic Risk Assessment The ACRS Subcommittee on Reliability and Probabilistic Risk Assessment (PRA) will hold a meeting on September 20, 2011, Room T-2B1, 11545 Rockville Pike... Memorandum on Modifying the Risk-Informed Regulatory Guidance for New Reactors. The Subcommittee will hear...

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2010-09-29

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77 FR 50121 - Hospira, Inc.; Withdrawal of Approval of a New Drug Application for DEXTRAN 70

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2012-08-20

..., Center for Biologics Evaluation and Research (HFM-17), Food and Drug Administration, 1401 Rockville Pike... and Research, by the Commissioner of Food and Drugs, approval of NDA 080- 819, DEXTRAN 70 [6% Dextran... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0840...

Molecular and Phenotypic Evidence of a New Species of Genus Esox (Esocidae, Esociformes, Actinopterygii): The Southern Pike, Esox flaviae

PubMed Central

Lucentini, Livia; Puletti, Maria Elena; Ricciolini, Claudia; Gigliarelli, Lilia; Fontaneto, Diego; Lanfaloni, Luisa; Bilò, Fabiana; Natali, Mauro; Panara, Fausto

2011-01-01

We address the taxonomic position of the southern European individuals of pike, performing a series of tests and comparisons from morphology, DNA taxonomy and population genetics parameters, in order to support the hypothesis that two species of pike, and not only one, exist in Europe. A strong relationship emerged between a northern genotype supported by COI, Cytb, AFLP and specific fragments, and a phenotype with round spot skin colour pattern and a large number of scales in the lateral line, clearly separated from a southern genotype with other skin colour pattern and a low number of scales in the lateral line. DNA taxonomy, based on a coalescent approach (GMYC) from phylogenetic reconstructions on COI and Cytb together with AFLP admixture analysis, supported the existence of two independently evolving entities. Such differences are not simply due to geographic distances, as northern European samples are more similar to Canadian and Chinese samples than the southern Europe ones. Thus, given that the differences between the two groups of European pike are significant at the phenotypic, genotypic and geographical levels, we propose the identification of two pike species: the already known northern pike (Esox lucius) and the southern pike (E. flaviae n.sp.). The correct identification of these two lineages as independent species should give rise to a ban on the introduction of northern pikes in southern Europe for recreational fishing, due to potential problems of hybridisation. PMID:22164201

76 FR 71125 - Caddo Valley Railroad Company-Abandonment Exemption-in Clark, Pike, and Montgomery Counties, AR

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. AB 1076X] Caddo Valley Railroad Company--Abandonment Exemption--in Clark, Pike, and Montgomery Counties, AR Caddo Valley Railroad... milepost 479.2, at the end of the line near Birds Mill, a distance of 32.2 miles, in Clark, Pike, and...

Aquatic assessment of the Pike Hill Copper Mine Superfund site, Corinth, Vermont

USGS Publications Warehouse

Piatak, Nadine M.; Argue, Denise M.; Seal, Robert R.; Kiah, Richard G.; Besser, John M.; Coles, James F.; Hammarstrom, Jane M.; Levitan, Denise M.; Deacon, Jeffrey R.; Ingersoll, Christopher G.

2013-01-01

The Pike Hill Copper Mine Superfund site in Corinth, Orange County, Vermont, includes the Eureka, Union, and Smith mines along with areas of downstream aquatic ecosystem impairment. The site was placed on the U.S. Environmental Protection Agency (USEPA) National Priorities List in 2004. The mines, which operated from about 1847 to 1919, contain underground workings, foundations from historical structures, several waste-rock piles, and some flotation tailings. The mine site is drained to the northeast by Pike Hill Brook, which includes several wetland areas, and to the southeast by an unnamed tributary that flows to the south and enters Cookville Brook. Both brooks eventually drain into the Waits River, which flows into the Connecticut River. The aquatic ecosystem at the site was assessed using a variety of approaches that investigated surface-water quality, sediment quality, and various ecological indicators of stream-ecosystem health. The degradation of surface-water quality is caused by elevated concentrations of copper, and to a lesser extent cadmium, with localized effects caused by aluminum, iron, and zinc. Copper concentrations in surface waters reached or exceeded the USEPA national recommended chronic water-quality criteria for the protection of aquatic life in all of the Pike Hill Brook sampling locations except for the location farthest downstream, in half of the locations sampled in the tributary to Cookville Brook, and in about half of the locations in one wetland area located in Pike Hill Brook. Most of these same locations also contained concentrations of cadmium that exceeded the chronic water-quality criteria. In contrast, surface waters at background sampling locations were below these criteria for copper and cadmium. Comparison of hardness-based and Biotic Ligand Model (BLM)-based criteria for copper yields similar results with respect to the extent or number of stations impaired for surface waters in the affected area. However, the BLM

Evidence for overestimation of the prevalence of malignancy in indeterminate thyroid nodules classified as Bethesda category III.

PubMed

Iskandar, Mazen E; Bonomo, Giovanni; Avadhani, Vaidehi; Persky, Mark; Lucido, David; Wang, Beverly; Marti, Jennifer L

2015-03-01

Several recent analyses of indeterminate thyroid nodules classified as Bethesda III (follicular lesion of undetermined significance) have reported considerably greater rates of malignancy than those initially reported by the Bethesda System for Reporting Cytopathology (BSRTC). These values, however, may be overestimates owing to several sources of bias, such as referral, selection, and publication biases. Our aim was to analyze the prevalence of malignancy in Bethesda III and IV thyroid nodules in a comprehensive health system less prone to institutional referral bias, excluding incidental carcinomas, and we examine the literature for publication bias. We performed a retrospective analysis with pathologic re-review of 119 patients with Bethesda III/IV cytology undergoing surgery in a comprehensive health system by examining patient and nodule characteristics. A review of the literature was performed and analyzed for publication bias. The malignancy rate in resected thyroid nodules was 13% (6/48) for Bethesda III and 28% (20/71) for Bethesda IV. There were 9 of 119 patients (8%) with incidental microcarcinomas. Age <30 years was associated with an increased risk of malignancy (odds ratio, 25.8; P = .005). Sex, nodule size, and ultrasonographic features were not associated with risk of malignancy. Analysis of the literature was indicative of publication bias for Bethesda III cohorts, with reported rates positively skewed (P = .039). In a comprehensive health system, the rate of malignancy in Bethesda III nodules was similar to the range reported by the BSRTC. Recent reports of greater rates of malignancy may be attributable to institutional referral patterns, operative selection, inclusion of incidental microcarcinomas, and publication bias. Copyright © 2015 Elsevier Inc. All rights reserved.

Year-class formation of upper St. Lawrence River northern pike

USGS Publications Warehouse

Smith, B.M.; Farrell, J.M.; Underwood, H.B.; Smith, S.J.

2007-01-01

Variables associated with year-class formation in upper St. Lawrence River northern pike Esox lucius were examined to explore population trends. A partial least-squares (PLS) regression model (PLS 1) was used to relate a year-class strength index (YCSI; 1974-1997) to explanatory variables associated with spawning and nursery areas (seasonal water level and temperature and their variability, number of ice days, and last day of ice presence). A second model (PLS 2) incorporated four additional ecological variables: potential predators (abundance of double-crested cormorants Phalacrocorax auritus and yellow perch Perca flavescens), female northern pike biomass (as a measure of stock-recruitment effects), and total phosphorus (productivity). Trends in adult northern pike catch revealed a decline (1981-2005), and year-class strength was positively related to catch per unit effort (CPUE; R2 = 0.58). The YCSI exceeded the 23-year mean in only 2 of the last 10 years. Cyclic patterns in the YCSI time series (along with strong year-classes every 4-6 years) were apparent, as was a dampening effect of amplitude beginning around 1990. The PLS 1 model explained over 50% of variation in both explanatory variables and the dependent variable, YCSI first-order moving-average residuals. Variables retained (N = 10; Wold's statistic ??? 0.8) included negative YCSI associations with high summer water levels, high variability in spring and fall water levels, and variability in fall water temperature. The YCSI exhibited positive associations with high spring, summer, and fall water temperature, variability in spring temperature, and high winter and spring water level. The PLS 2 model led to positive YCSI associations with phosphorus and yellow perch CPUE and a negative correlation with double-crested cormorant abundance. Environmental variables (water level and temperature) are hypothesized to regulate northern pike YCSI cycles, and dampening in YCSI magnitude may be related to a

A radiation briefer's guide to the PIKE Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steadman, Jr, C R

1990-03-01

Gamma-radiation-exposure estimates to populations living immediately downwind from the Nevada Test Site have been required for many years by the US Department of Energy (DOE) before each containment-designed nuclear detonation. A highly unlikely worst-case'' scenario is utilized which assumes that there will be an accidental massive venting of radioactive debris into the atmosphere shortly after detonation. The Weather Service Nuclear Support Office (WSNSO) has supplied DOE with such estimates for the last 25 years using the WSNSO Fallout Scaling Technique (FOST), which employs a worst-case analog event that actually occurred in the past. The PIKE Model'' is the application ofmore » the FOST using the PIKE nuclear event as the analog. This report, which is primarily intended for WSNSO meteorologists who derive radiation estimates, gives a brief history of the model,'' presents the mathematical, radiological, and meteorological concepts upon which it is based, states its limitations, explains it apparent advantages over more sophisticated models, and details how it is used operationally. 10 refs., 31 figs., 7 tabs.« less

76 FR 32240 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-03

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital Instrumentation and Control Systems; Notice of Meeting The ACRS Subcommittee on Digital Instrumentation and Control Systems (DI&C) will hold a meeting on June 7, 2011, Room T-2B1, 11545 Rockville Pike...

76 FR 44964 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on U.S...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-27

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on U.S. Evolutionary Power Reactor; Notice of Meeting The ACRS Subcommittee on U.S. Evolutionary Power Reactor (U.S. EPR) will hold a meeting on August 18, 2011, Room T-2B3, 11545 Rockville Pike...

77 FR 74697 - Meeting of the ACRS, Subcommittee on U.S. Evolutionary Power Reactor; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-17

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS, Subcommittee on U.S. Evolutionary Power Reactor; Notice of Meeting The ACRS Subcommittee on U.S. Evolutionary Power Reactor (U.S. EPR) will hold a meeting on January 17, 2013, Room T-2B1, 11545 Rockville Pike...

75 FR 3501 - Advisory Committee on Reactor Safeguards

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2010-01-21

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards In accordance with the purposes of Sections 29 and 182b of the Atomic Energy Act (42 U.S.C. 2039, 2232b), the Advisory Committee on Reactor Safeguards (ACRS) will hold a meeting on February 4-6, 2010, 11545 Rockville Pike...

78 FR 17936 - National Cancer Institute Amended; Notice of Meeting

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2013-03-25

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute Amended; Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, April 24, 2013, 8:30 a.m.-4:30 p.m., 9000 Rockville Pike, Building 45...

78 FR 79699 - Cellular, Tissue, and Gene Therapies Advisory Committee; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-31

... Harvey, Food and Drug Administration, Center for Biologics Evaluation and Research, 1401 Rockville Pike... Biologics Evaluation and Research (CBER), FDA. On February 26, 2014, from 1 p.m. to approximately 5 p.m... and gene therapy products. CBER published guidance on this topic in July 2013 ( http://www.fda.gov...

21 CFR 201.25 - Bar code label requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... and Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 51, Silver Spring, MD...-600), Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike... 21 Food and Drugs 4 2011-04-01 2011-04-01 false Bar code label requirements. 201.25 Section 201.25...

Efficiency of the Bethesda System for Thyroid Cytopathology.

PubMed

Mora-Guzmán, Ismael; Muñoz de Nova, José Luis; Marín-Campos, Cristina; Jiménez-Heffernan, José Antonio; Cuesta Pérez, Juan Julián; Lahera Vargas, Marcos; Torres Mínguez, Emma; Martín-Pérez, Elena

2018-03-28

Fine-needle aspiration biopsies are a key tool for preoperative assessment of thyroid nodules, and the Bethesda system is the preferred method to report cytological analysis. The purpose of this study is to assess the efficiency of the Bethesda system to identify the malignancy risk of thyroid nodules. Patients who underwent thyroid surgery between June 2010 and June 2017 were included. Samples were classified into 6categories according to rates of malignancy associated with each diagnostic category. In order to investigate the correlation between categories, a statistical analysis compared the categories with pathology reports. Diagnostic indicators were calculated as a screening test (categories IV, V, VI as true-positive) and as a method to identify malignancy (V, VI as true-positive). In a series of 522 patients, we found 184 (35.2%) malignant tumours, papillary carcinoma being the most prevalent with 155 cases (84.2%). Malignant rates for diagnostic categories were: I, 0%; II, 1.5%; III, 6.4%; IV, 31%; V, 86.5%; VI, 100%. A robust correlation was identified between categories on statistical analysis. For the «screening test» analysis, sensitivity was 98.9%, specificity 84.4%, positive predictive value 69.6%, negative predictive value 99.5%, and diagnostic accuracy 88.2%. Analysing the accuracy to detect malignancy, values were: sensitivity 98.6%, specificity 97.6%, positive predictive value 93.5%, negative predictive value 99.5%, diagnostic accuracy 97.9%. The Bethesda system is a clear and reliable approach to report thyroid cytology and therefore is an effective tool to identify malignancy risk and guide clinical management. Copyright © 2018 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

76 FR 43333 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-20

...: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience Center.../NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda, MD 20892-9529, 301... Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call...

76 FR 58285 - National Institute of Mental Health Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... Officer, Division of Extramural Activities, National Institute of Mental Health, NIH, Neuroscience Center..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person... of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd, Room 6149, MSC 9608, Bethesda, MD...

76 FR 10380 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person... Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6151, MSC 9606, Bethesda, MD 20892.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience...

78 FR 39299 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-01

.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience... of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd, Room 6140, MSC 9608, Bethesda, MD... applications. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville...

76 FR 69747 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person... Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda, MD.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience...

77 FR 38847 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience... of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6140, MSC 9608, Bethesda, MD... Health,Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call...

78 FR 59944 - National Institute of Mental Health; Notice of Closed Meetings

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2013-09-30

... of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference... Activities, National Institute of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6140... Institute of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6149, MSC 9608, Bethesda...

76 FR 34717 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-14

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call) Contact Person... Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6151, MSC 9606, Bethesda, MD 20892.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience...

76 FR 60508 - National Institute of Mental Health Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience... of Mental Health, NIH, Neuroscience Center/Room 6138/MSC 9608, 6001 Executive Boulevard, Bethesda, MD..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person...

Pike Esox Lucius Distribution and Feeding Comparisons in Natural and Historically Channelized River Sections

NASA Astrophysics Data System (ADS)

Ivanovs, Kaspars

2016-12-01

During the last century a large portion of small and medium-sized rivers in Latvia were channelized, hydroelectric power stations were also built, which led to changes in the hydrodynamic conditions, geomorphological structure, as well as a change in the fish fauna. Fish are an integral part of any community in natural or man-made bodies of water. They actively participate in maintaining the system, balancing/equilibrium, energy, substance transformation and biomass production. They are able to influence other organisms in the ecosystem in which they live. The aim of the paper "Pike distribution and feeding comparisons in natural and historically channelized river sections" is to find out what pike feed on in different environments in Latvian rivers, such as natural and straightened river sections, as well as what main factors determine the composition of their food. Several points were assessed during the course of the study: the impact of environmental conditions on the feeding habits and the distribution of pike; the general feeding habits of predators in Latvian rivers; the feeding differences of predators in natural and straightened river sections; and lastly, rhithral and pothamal habitats were compared. The study was based on data from 2014 and 2015 on fish fauna monitoring. During the study, 347 pike were collected from 136 plots using electrofishing method.

78 FR 32279 - Advisory Committee On Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-29

... NUCLEAR REGULATORY COMMISSION Advisory Committee On Reactor Safeguards; Notice of Meeting In accordance with the purposes of Sections 29 and 182b of the Atomic Energy Act (42 U.S.C. 2039, 2232b), the Advisory Committee on Reactor Safeguards (ACRS) will hold a meeting on June 5-7, 2013, 11545 Rockville Pike...

77 FR 2076 - National Institute of Mental Health Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-13

... Institute of Mental Health, NIH Neuroscience Center, 6001 Executive Blvd., Room 6153, MSC 9608, Bethesda, MD... Institutes of Health Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference... Activities, National Institute of Mental Health, NIH Neuroscience Center, 6001 Executive Blvd., Room 6148...

76 FR 16432 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Virtual Meeting). Contact Person: JoAnn.../ NIH/DHHS/Neuroscience Center, 6001 Executive Boulevard, Suite 3208, MSC 9529, Bethesda, MD 20892-9529..., Clinical Research Related to Neurological Disorders; 93.854, Biological Basis Research in the Neurosciences...

76 FR 18230 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

... Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852. (Telephone Conference Call... Boulevard; MSC 9529, Neuroscience Center, Room 3203, Bethesda, MD 20892-9529, 301-496- 5388, [email protected] Neurological Disorders; 93.854, Biological Basis Research in the Neurosciences, National Institutes of Health...

75 FR 39548 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-09

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person... Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, Msc 9529, Bethesda, MD... Neurosciences, National Institutes of Health, HHS) Dated: July 1, 2010. Jennifer Spaeth, Director, Office of...

76 FR 10381 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call) Contact Person..., Neuroscience Center; Room 3203, Bethesda, MD 20892-9529, 301-496- 5388, [email protected] . [[Page 10382..., Clinical Research Related to Neurological Disorders; 93.854, Biological Basis Research in the Neurosciences...

78 FR 64227 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-28

... review and evaluate grant applications. Place: National Institutes of Health, Neuroscience Center, 6001..., Neuroscience Center, 6001 Executive BLVD, Room 6140, MSC 9608, Bethesda, MD 20892-9608, 301-443-9734, millerda... applications. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville...

75 FR 8373 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience... Health, NIH, Neuroscience Center, 6001 Executive Boulevard, Room 6132, MSC 9608, Bethesda, MD 20852-9608... Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6148, MSC 9609, Rockville, MD 20852...

77 FR 19025 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-29

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person... Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda, MD... Neurosciences, National Institutes of Health, HHS) Dated: March 23, 2012. Jennifer S. Spaeth, Director, Office...

76 FR 10382 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call) Contact Person... Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Boulevard, Suite 3208, MSC 9529, Bethesda, MD..., Clinical Research Related to Neurological Disorders; 93.854, Biological Basis Research in the Neurosciences...

76 FR 52961 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-24

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person..., Neuroscience Center, Room 3203, Bethesda, MD 20892-9529, 301-496- 5388, [email protected] . This notice is... Research Related to Neurological Disorders; 93.854, Biological Basis Research in the Neurosciences...

76 FR 41273 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person... Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda, MD..., Clinical Research Related to Neurological Disorders; 93.854, Biological Basis Research in the Neurosciences...

76 FR 17141 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-28

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person..., NINDS/ NIH/DHHS/Neuroscience Center, 6001 Executive Boulevard, Suite 3208, MSC 9529, Bethesda, MD 20892....854, Biological Basis Research in the Neurosciences, National Institutes of Health, HHS) Dated: March...

75 FR 82094 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on U.S...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on U.S. Evolutionary Power Reactor (U.S. EPR); Notice of Meeting The ACRS Subcommittee on U.S. Evolutionary Power Reactor (U.S. EPR) will hold a meeting on January 12, 2011, Room T-2B1, 11545 Rockville Pike...

Using bioenergetics modeling to estimate consumption of native juvenile salmonids by nonnative northern pike in the Upper Flathead River System, Montana

USGS Publications Warehouse

Muhlfeld, C.C.; Bennett, D.H.; Kirk, Steinhorst R.; Marotz, B.; Boyer, M.

2008-01-01

Introductions of nonnative northern pike Esox lucius have created recreational fisheries in many waters in the United States and Canada, yet many studies have shown that introduced northern pike may alter the composition and structure of fish communities through predation. We estimated the abundance of nonnative northern pike (2002-2003) and applied food habits data (1999-2003) to estimate their annual consumption of native bull trout Salvelinus confluentus and westslope cutthroat trout Oncorhynchus clarkii lewisi juveniles in the upper Flathead River system, Montana. Population estimates were generally consistent among years and ranged from 1,200 to 1,300 individuals. Westslope cutthroat trout were present in the diet of younger (???600 mm) and older (>600 mm) northern pike during all seasons and bull trout were found only in larger northern pike during all seasons but summer. Bioenergetics modeling estimated that the northern pike population annually consumed a total of 8.0 metric tons (mt) of fish flesh; the highest biomass was composed of cyprinids (4.95 mt) followed by whitefishes Prosopium spp. (1.02 mt), bull trout (0.80 mt), westslope cutthroat trout (0.68 mt), yellow perch Perca flavescens (0.41 mt),1 and other fishes (centrarchids and cottids; 0.14 mt). Numerically, the northern pike population consumed more than 342,000 fish; cyprinids and catostomids comprised approximately 82% of prey fish (278,925), whereas over 13,000 westslope cutthroat trout and nearly 3,500 bull trout were eaten, comprising about 5% of the prey consumed. Our results suggest that predation by introduced northern pike is contributing to the lower abundance of native salmonids in the system and that a possible benefit might accrue to native salmonids by reducing these predatory interactions. ?? Copyright by the American Fisheries Society 2008.

77 FR 63847 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-17

..., Neuroscience Center, 6001 Executive Blvd., Room 6148, MSC 9609, Rockville, MD 20852-9609, 301-402-6807, libbeym...: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience Center... Institute of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6151, MSC 9606, Bethesda...

75 FR 13768 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-23

... Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852. Contact Person: Phillip F. Wiethorn, Scientific Review Administrator, DHHS/NIH/NINDS/DER/SRB, 6001 Executive Boulevard; MSC 9529, Neuroscience..., Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529,Bethesda, MD 20892-9529, 301-496-4056, lyonse...

76 FR 17660 - National Institute of Mental Health; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-30

... Health, Neuroscience Center, 6001 Executive Boulevard, Conference Room C/D/E, Rockville, MD 20852. Open...: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Conference Room C/D/E..., NIH, Neuroscience Center, 6001 Executive Blvd., Room 6154, MSC 9609, Bethesda, MD 20892-9609, 301-443...

75 FR 27350 - National Institute of Mental Health; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-14

... Neuroscience Diversity Undergraduate Research Education Applications. Date: June 8, 2010. Time: 11 a.m. to 4 p..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call) Contact Person... of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6149, MSC 9608, Bethesda, MD...

76 FR 52716 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-23

... Register on Thursday, October 21, 2010 (75 FR 65038-65039). Thursday, September 8, 2011, Conference Room T2... low-level waste disposal and site- specific analysis. 1:15 p.m.-3:15 p.m.: Safety Evaluation Report... U.S.C. 552b(c)(4).] Friday, September 9, 2011, Conference Room T2-B1, 11545 Rockville Pike...

76 FR 16457 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... Thursday, October 21, 2010 (74 FR 65038-65039). Thursday, April 7, 2011, Conference Room T2-B1, 11545....: Selected Chapters of the Safety Evaluation Report (SER) with Open Items Associated with the Calvert Cliffs... pursuant to 5 U.S.C. 552b(c)(4).] Friday, April 8, 2011, Conference Room T2-B1, 11545 Rockville Pike...

Fine scale habitat use by age-1 stocked muskellunge and wild northern pike in an upper St. Lawrence River bay

USGS Publications Warehouse

Farrell, John M.; Kapuscinski, Kevin L.; Underwood, Harold

2014-01-01

Radio telemetry of stocked muskellunge (n = 6) and wild northern pike (n = 6) was used to track late summer and fall movements from a common release point in a known shared nursery bay to test the hypothesis that age-1 northern pike and stocked muskellunge segregate and have different habitat affinities. Water depth, temperature, substrate and aquatic vegetation variables were estimated for each muskellunge (n = 103) and northern pike (n = 131) position and nested ANOVA comparisons by species indicated differences in habitat use. Muskellunge exhibited a greater displacement from the release point and used habitat in shallower water depths (mean = 0.85 m, SE = 0.10) than northern pike (mean = 1.45 m, SE = 0.08). Both principal components analysis (PCA) and principal components ordination (PCO) were used to interpret underlying gradients relative to fish positions in two-dimensional space. Our analysis indicated that a separation of age-1 northern pike and muskellunge occurred 7 d post-release. This first principal component explained 48% of the variation in habitat use. Northern pike locations were associated with deeper habitats that generally had softer silt substrates and dense submersed vegetation. Muskellunge locations post-acclimation showed greater association with shallower habitats containing firmer sandy and clay substrates and emergent vegetation. The observed differences in habitat use suggest that fine-scale ecological separation occurred between these stocked muskellunge and wild northern pike, but small sample sizes and potential for individual variation limit extension of these conclusions. Further research is needed to determine if these patterns exist between larger samples of fishes over a greater range of habitats.

75 FR 6675 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6151, MSC 9606, Bethesda, MD 20892-9606, 301... review and evaluate grant applications. Place: National Institutes of Health, Neuroscience Center, 6001..., Neuroscience Center, 6001 Executive Blvd., Room 6154, MSC 9609, Rockville, MD 20892-9609, 301-443-0004, sechu...

75 FR 61227 - Sunshine Act: Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-04

... on Security Issues (Closed--Ex. 1). Week of November 1, 2010--Tentative Tuesday, November 2, 2010 9..., 2010 1:30 p.m.--NRC All Employees Meeting (Public Meeting), Marriott Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m.--Briefing on Medical Issues (Public...

75 FR 62894 - Sunshine Federal Register Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-13

..., October 26, 2010 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1). Week of November 1, 2010... Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m. Briefing on Medical Issues (Public Meeting), (Contact: Michael Fuller, 301-415-0520). This meeting will be...

77 FR 65728 - Notice of Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-30

....nrc.gov. Thursday, November 29, 2012 2:30 p.m. Briefing on Security issues (Closed Ex-1) Week of... Meeting (Public Meeting), Marriott Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Thursday, November 8, 2012 9:30 a.m. Discussion of Management Issues (Closed--Ex. 2). Week of November 12...

75 FR 64367 - Sunshine Federal Register Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-19

..., October 26, 2010 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1) Week of November 1, 2010--Tentative... Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m. Briefing on Medical Issues (Public Meeting). (Contact: Michael Fuller, 301-415-0520.) This meeting will be...

75 FR 11895 - National Institute of General Medical Sciences; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

... confidential trade secrets or commercial property such as patentable material, and personal information... Sciences Special Emphasis Panel, Modeling the Scientific Workforce. Date: April 5, 2010. Time: 1 p.m. to 3..., Natcher Building, 45 Center Drive, Room 3AN.34, Bethesda, MD 20892. Contact Person: Brian R. Pike, PhD...

HEAT EXCHANGER BUILDING, TRA644. NORTHEAST CORNER. CAMERA IS ON PIKE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HEAT EXCHANGER BUILDING, TRA-644. NORTHEAST CORNER. CAMERA IS ON PIKE STREET FACING SOUTHWEST. ATTACHED STRUCTURE AT RIGHT OF VIEW IS ETR COMPRESSOR BUILDING, TRA-643. INL NEGATIVE NO. HD46-36-4. Mike Crane, Photographer, 4/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Locations & Contacts | Cancer Prevention Fellowship Program

Cancer.gov

The Principles and Practice of Cancer Prevention and Control course is held in July. The Molecular Prevention course is held in early August. Both courses will be held in Bethesda or Rockville, Maryland. Lectures are usually scheduled Monday through Friday, from 9:00 a.m. to 3:30 p.m. (lecture times may vary year to year).

78 FR 66024 - National Cancer Institute; Amended Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-04

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, October 16, 2013, 08:00 a.m. to October 17, 2013, 05:00 p.m., Bethesda North Marriott, Rockville, MD which was...

The effects of pulse pressure from seismic water gun technology on Northern Pike

USGS Publications Warehouse

Gross, Jackson A.; Irvine, Kathryn M.; Wilmoth, Siri K.; Wagner, Tristany L.; Shields, Patrick A; Fox, Jeffrey R.

2013-01-01

We examined the efficacy of sound pressure pulses generated from a water gun for controlling invasive Northern Pike Esox lucius. Pulse pressures from two sizes of water guns were evaluated for their effects on individual fish placed at a predetermined random distance. Fish mortality from a 5,620.8-cm3 water gun (peak pressure source level = 252 dB referenced to 1 μP at 1 m) was assessed every 24 h for 168 h, and damage (intact, hematoma, or rupture) to the gas bladder, kidney, and liver was recorded. The experiment was replicated with a 1,966.4-cm3 water gun (peak pressure source level = 244 dB referenced to 1 μP at 1 m), but fish were euthanized immediately. The peak sound pressure level (SPLpeak), peak-to-peak sound pressure level (SPLp-p), and frequency spectrums were recorded, and the cumulative sound exposure level (SELcum) was subsequently calculated. The SPLpeak, SPLp-p, and SELcum were correlated, and values varied significantly by treatment group for both guns. Mortality increased and organ damage was greater with decreasing distance to the water gun. Mortality (31%) by 168 h was only observed for Northern Pike exhibiting the highest degree of organ damage. Mortality at 72 h and 168 h postexposure was associated with increasing SELcum above 195 dB. The minimum SELcum calculated for gas bladder rupture was 199 dB recorded at 9 m from the 5,620.8-cm3 water gun and 194 dB recorded at 6 m from the 1,966.4-cm3water gun. Among Northern Pike that were exposed to the large water gun, 100% of fish exposed at 3 and 6 m had ruptured gas bladders, and 86% exposed at 9 m had ruptured gas bladders. Among fish that were exposed to pulse pressures from the smaller water gun, 78% exhibited gas bladder rupture. Results from these initial controlled experiments underscore the potential of water guns as a tool for controlling Northern Pike.

Complete sequences of 4 viral hemorrhagic septicemia virus IVb isolates and their virulence in northern pike fry

USGS Publications Warehouse

Getchell, Rodman G.; Cornwell, Emily R.; Bogdanowicz, Steven; Andres, Jose; Batts, William N.; Kurath, Gael; Breyta, Rachel; Choi, Joanna G.; Farrell, John M.; Bowser, Paul R.

2017-01-01

Four viral hemorrhagic septicemia virus (VHSV) genotype IVb isolates were sequenced, their genetic variation explored, and comparative virulence assayed with experimental infections of northern pike Esox lucius fry. In addition to the type strain MI03, the complete 11183 bp genome of the first round goby Neogobius melanostomus isolate from the St. Lawrence River, and the 2013 and 2014 isolates from gizzard shad Dorosoma cepedianum die-offs in Irondequoit Bay, Lake Ontario and Dunkirk Harbor, Lake Erie were all deep sequenced on an Illumina platform. Mutations documented in the 11 yr since the MI03 index case from Lake St. Clair muskellunge Esox masquinongy showed 87 polymorphisms among the 4 isolates. Twenty-six mutations were non-synonymous and located at 18 different positions within the matrix protein, glycoprotein, non-virion protein, and RNA polymerase genes. The same 4 isolates were used to infect northern pike fry by a single 1 h bath exposure. Cumulative percent mortality varied from 42.5 to 62.5%. VHSV was detected in 57% (41/72) of the survivors at the end of the 21-d trial, suggesting that the virus was not rapidly cleared. Lesions were observed in many of the moribund and dead northern pike, such as hemorrhaging in the skin and fins, as well as hydrocephalus. Mean viral load measured from the trunk and visceral tissues of MI03-infected pike was significantly higher than the quantities detected in fish infected with the most recent isolates of genotype IVb, but there were no differences in cumulative mortality observed.

Complete sequences of 4 viral hemorrhagic septicemia virus IVb isolates and their virulence in northern pike fry.

PubMed

Getchell, Rodman G; Cornwell, Emily R; Bogdanowicz, Steven; Andrés, Jose; Batts, William N; Kurath, Gael; Breyta, Rachel; Choi, Joanna G; Farrell, John M; Bowser, Paul R

2017-11-21

Four viral hemorrhagic septicemia virus (VHSV) genotype IVb isolates were sequenced, their genetic variation explored, and comparative virulence assayed with experimental infections of northern pike Esox lucius fry. In addition to the type strain MI03, the complete 11183 bp genome of the first round goby Neogobius melanostomus isolate from the St. Lawrence River, and the 2013 and 2014 isolates from gizzard shad Dorosoma cepedianum die-offs in Irondequoit Bay, Lake Ontario and Dunkirk Harbor, Lake Erie were all deep sequenced on an Illumina platform. Mutations documented in the 11 yr since the MI03 index case from Lake St. Clair muskellunge Esox masquinongy showed 87 polymorphisms among the 4 isolates. Twenty-six mutations were non-synonymous and located at 18 different positions within the matrix protein, glycoprotein, non-virion protein, and RNA polymerase genes. The same 4 isolates were used to infect northern pike fry by a single 1 h bath exposure. Cumulative percent mortality varied from 42.5 to 62.5%. VHSV was detected in 57% (41/72) of the survivors at the end of the 21-d trial, suggesting that the virus was not rapidly cleared. Lesions were observed in many of the moribund and dead northern pike, such as hemorrhaging in the skin and fins, as well as hydrocephalus. Mean viral load measured from the trunk and visceral tissues of MI03-infected pike was significantly higher than the quantities detected in fish infected with the most recent isolates of genotype IVb, but there were no differences in cumulative mortality observed.

Genetic structure of pike (Esox lucius) reveals a complex and previously unrecognized colonization history of Ireland

PubMed Central

Pedreschi, Debbi; Kelly-Quinn, Mary; Caffrey, Joe; O’Grady, Martin; Mariani, Stefano; Phillimore, Albert

2014-01-01

Aim We investigated genetic variation of Irish pike populations and their relationship with European outgroups, in order to elucidate the origin of this species to the island, which is largely assumed to have occurred as a human-mediated introduction over the past few hundred years. We aimed thereby to provide new insights into population structure to improve fisheries and biodiversity management in Irish freshwaters. Location Ireland, Britain and continental Europe. Methods A total of 752 pike (Esox lucius) were sampled from 15 locations around Ireland, and 9 continental European sites, and genotyped at six polymorphic microsatellite loci. Patterns and mechanisms of population genetic structure were assessed through a diverse array of methods, including Bayesian clustering, hierarchical analysis of molecular variance, and approximate Bayesian computation. Results Varying levels of genetic diversity and a high degree of population genetic differentiation were detected. Clear substructure within Ireland was identified, with two main groups being evident. One of the Irish populations showed high similarity with British populations. The other, more widespread, Irish strain did not group with any European population examined. Approximate Bayesian computation suggested that this widespread Irish strain is older, and may have colonized Ireland independently of humans. Main conclusions Population genetic substructure in Irish pike is high and comparable to the levels observed elsewhere in Europe. A comparison of evolutionary scenarios upholds the possibility that pike may have colonized Ireland in two ‘waves’, the first of which, being independent of human colonization, would represent the first evidence for natural colonization of a non-anadromous freshwater fish to the island of Ireland. Although further investigations using comprehensive genomic techniques will be necessary to confirm this, the present results warrant a reappraisal of current management strategies

Genetic structure of pike (Esox lucius) reveals a complex and previously unrecognized colonization history of Ireland.

PubMed

Pedreschi, Debbi; Kelly-Quinn, Mary; Caffrey, Joe; O'Grady, Martin; Mariani, Stefano; Phillimore, Albert

2014-03-01

We investigated genetic variation of Irish pike populations and their relationship with European outgroups, in order to elucidate the origin of this species to the island, which is largely assumed to have occurred as a human-mediated introduction over the past few hundred years. We aimed thereby to provide new insights into population structure to improve fisheries and biodiversity management in Irish freshwaters. Ireland, Britain and continental Europe. A total of 752 pike ( Esox lucius ) were sampled from 15 locations around Ireland, and 9 continental European sites, and genotyped at six polymorphic microsatellite loci. Patterns and mechanisms of population genetic structure were assessed through a diverse array of methods, including Bayesian clustering, hierarchical analysis of molecular variance, and approximate Bayesian computation. Varying levels of genetic diversity and a high degree of population genetic differentiation were detected. Clear substructure within Ireland was identified, with two main groups being evident. One of the Irish populations showed high similarity with British populations. The other, more widespread, Irish strain did not group with any European population examined. Approximate Bayesian computation suggested that this widespread Irish strain is older, and may have colonized Ireland independently of humans. Population genetic substructure in Irish pike is high and comparable to the levels observed elsewhere in Europe. A comparison of evolutionary scenarios upholds the possibility that pike may have colonized Ireland in two 'waves', the first of which, being independent of human colonization, would represent the first evidence for natural colonization of a non-anadromous freshwater fish to the island of Ireland. Although further investigations using comprehensive genomic techniques will be necessary to confirm this, the present results warrant a reappraisal of current management strategies for this species.

Multiple isotope analyses of the pike tapeworm Triaenophorus nodulosus reveal peculiarities in consumer-diet discrimination patterns.

PubMed

Behrmann-Godel, J; Yohannes, E

2015-03-01

Previous studies of dietary isotope discrimination have led to the general expectation that a consumer will exhibit enriched stable isotope levels relative to its diet. Parasite-host systems are specific consumer-diet pairs in which the consumer (parasite) feeds exclusively on one dietary source: host tissue. However, the small numbers of studies previously carried out on isotopic discrimination in parasite-host (ΔXP-HT) systems have yielded controversial results, showing some parasites to be isotopically depleted relative to their food source, while others are enriched or in equilibrium with their hosts. Although the mechanism for these deviations from expectations remains to be understood, possible influences of specific feeding niche or selection for only a few nutritional components by the parasite are discussed. ΔXP-HT for multiple isotopes (δ13C, δ15N, δ34S) were measured in the pike tapeworm Triaenophorus nodulosus and two of its life-cycle fish hosts, perch Perca fluviatilis and pike Esox lucius, within which T. nodulosus occupies different feeding locations. Variability in the value of ΔXP-HT calculated for the parasite and its different hosts indicates an influence of feeding location on isotopic discrimination. In perch liver ΔXP-HT was relatively more negative for all three stable isotopes. In pike gut ΔXP-HT was more positive for δ13C, as expected in conventional consumer-diet systems. For parasites feeding on pike gut, however, the δ15N and δ34S isotope values were comparable with those of the host. We discuss potential causes of these deviations from expectations, including the effect of specific parasite feeding niches, and conclude that ΔXP-HT should be critically evaluated for trophic interactions between parasite and host before general patterns are assumed.

Length-weight relationship of northern pike, Esox lucius, from East Harbor, Ohio

USGS Publications Warehouse

Brown, Edward H.; Clark, Clarence F.

1965-01-01

The northern pike is one of Ohio's largest game fish but is well known to comparatively few anglers. Large numbers of the big fish spawn in the Ohio marshes adjacent to Lake Erie. Movements related to spawning reach a peak in late March or early April. Later the spawning population disperses and is seldom represented in catches by experimental gear or by anglers. The short period of availability was used to obtain life history information in March of 1951 through 1953. No comprehensive length-weight data for this species have previously been published from this area. East Harbor is a sandspit pond separated from Lake Erie by a large sand bar. Waters and fish populations of the harbor and lake can mix freely through a permanent connecting channel. The larger part of the 850 surface acres of the harbor is normally less than 8 feet deep. The male northern pike averaged 20.5 inches in length and ranged from 13.5 to 28.5 inches. The conspicuously larger females averaged 26.0 inches and ranged from 15.5 to 37.5 inches.

Detracking with Vigilance: By Opening the High-Level Doors to All, Rockville Centre Closes the Gap in Achievement and Diplomas

ERIC Educational Resources Information Center

Garrity, Delia

2004-01-01

Can a diverse suburban high school on Long Island eliminate academic tracks and still produce high-achieving students? The answer in Rockville Centre, New York, is decidedly yes. Statistics tell part of the story: 60 percent of the senior class at South Side High School is enrolled in Advanced Placement calculus, including 40 percent of the…

Evaluation of the Efficacy of Iodophor Disinfection of Walleye and Northern Pike Eggs to Eliminate Viral Hemorrhagic Septicemia Virus

USGS Publications Warehouse

Tuttle-Lau, M.T.; Phillips, K.A.; Gaikowski, M.P.

2009-01-01

Viral hemorrhagic septicemia virus (VHSv) is a serious fish pathogen that has been responsible for large-scale fish kills in the Great Lakes since 2005. It causes high mortality and resulting outbreaks have severe economic consequences for aquaculture. Iodophor disinfection of salmonid eggs is a standard hatchery practice to reduce the risk of pathogen transfer during gamete collection ('spawning') operations and is thus a leading candidate for reducing VHSv transmission during and after spawning of nonsalmonid fishes. However, before it is incorporated by hatcheries during nonsalmonid fish spawning efforts, its safety and effectiveness needs to be evaluated. The USGS Fact Sheet 2009-3107, 'Evaluation of the Efficacy of Iodophor Disinfection of Walleye and Northern Pike Eggs to Eliminate Viral Hemorrhagic Septicemia Virus' presents the results of a study to assess the effectiveness of iodophor disinfection for eliminating VHSv (strain IVb) from fertilized eggs of walleye and northern pike intentionally challenged with VHSv following egg fertilization. Walleye and northern pike egg survival (hatch) following iodophor egg disinfection also was assessed.

Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-γ1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma

PubMed Central

Jiang, Yi; Liao, Liyan; Shrestha, Chandrama; Ji, Shangli; Chen, Ying; Peng, Jian; Wang, Larry; Liao, Eryuan; Xie, Zhongjian

2015-01-01

Oral squamous cell carcinoma (OSCC) is one of the most lethal malignant tumors. The cadherin/catenin cell-cell adhesion complex plays a major role in cancer development and progression. p120-catenin (p120) is a cytoplasmic molecule closely associated with E-cadherin which activates phospholipase C-γ1 (PLC-γ1). Our previous studies indicate that activation of PLC-γ1 plays a critical role in epidermal growth factor (EGF)-induced migration and proliferation of squamous cell carcinoma (SCC) cells and phosphatidylinositol 3-kinase enhancer (PIKE) is highly expressed in SCC cells and mediates EGFR-dependent SCC cell proliferation. Our current study was to determine whether the expression of E-cadherin, p120, PLC-γ1, and PIKE, is associated with OSCC. To address this issue, we assessed levels and localization of E-cadherin, p120, PLC-γ1, and PIKE in specimen of 92 patients with OSCC by immunohistochemistry. The results showed that the expression of E-cadherin, and p120 negatively correlated with the tumor differentiation and the expression of PLC-γ1 and PIKE positively correlated with the tumor differentiation. The expression of PLC-γ1 and PIKE in OSCC stage T3 + T4 or in OSCC with lymph node metastasis was significantly higher than that in OSCC stage T1 + T2 or in OSCC without lymph node metastasis. The expression of p120 positively correlated with levels of E-cadherin but negatively correlated with levels of PLC-γ1 and PIKE in OSCC. These data indicate that increased expression of PLC-γ1 and PIKE and decreased expression of E-cadherin and p120 are associated with the aggressiveness of OSCC. PMID:26464646

Mercury elimination rates for adult northern pike Esox lucius: evidence for a sex effect

USGS Publications Warehouse

Madenjian, Charles P.; Blanchfield, Paul J.; Hrenchuk, Lee E.; Van Walleghem, Jillian L. A.

2014-01-01

We examined the effect of sex on mercury elimination in fish by monitoring isotope-enriched mercury concentrations in the muscle tissue of three adult female and three adult male northern pike Esox lucius, which had accumulated the isotope-enriched mercury via a whole-lake manipulation and were subsequently moved to a clean lake. Mercury elimination rates for female and male northern pike were estimated to be 0.00034 and 0.00073 day−1, respectively. Thus, males were capable of eliminating mercury at more than double the rate than that of females. To the best of our knowledge, our study represents the first documentation of mercury elimination rates varying between the sexes of fish. This sex difference in elimination rates should be taken into account when comparing mercury accumulation between the sexes of fish from the same population. Further, our findings should eventually lead to an improved understanding of mechanisms responsible for mercury elimination in vertebrates.

Post-glacial dispersal patterns of Northern pike inferred from an 8800 year old pike (Esox cf. lucius) skull from interior Alaska

NASA Astrophysics Data System (ADS)

Wooller, Matthew J.; Gaglioti, Benjamin; Fulton, Tara L.; Lopez, Andres; Shapiro, Beth

2015-07-01

The biogeography of freshwater fish species during and after late-Pleistocene glaciations relate to how these species are genetically organized today, and the management of these often disjunct populations. Debate exists concerning the biogeography and routes of dispersal for Northern pike (Esox lucius) after the last glaciation. A hypothesis to account for the relatively low modern genetic diversity for E. lucius is post-glacial radiation from refugia, including lakes from within the un-glaciated portions of eastern Beringia. We report the remains of a Northern pike (E. cf. lucius) skull, including bones, teeth, bone collagen and ancient DNA. The remains were preserved at a depth of between 440 and 446 cm in a 670 cm long core of sediment from Quartz Lake, which initiated at ˜11,200 cal yr BP in interior Alaska. A calibrated accelerator mass spectrometer (AMS) radiocarbon age of the collagen extracted from the preserved bones indicated that the organism was dated to 8820 cal yr BP and is bracketed by AMS values from analyses of terrestrial plant macrofossils, avoiding any potential aquatic reservoir effect that could have influenced the radiocarbon age of the bones. Scanning electron microscope images of the specimen show the hinged tooth anatomy typically of E. lucius. Molar C:N (3.5, 1σ = 0.1) value of the collagen from the specimen indicated well-preserved collagen and its mean stable nitrogen isotope value is consistent with the known predatory feeding ecology of E. lucius. Ancient DNA in the bones showed that the specimen was identical to modern E. lucius. Our record of E. lucius from interior Alaska is consistent with a biogeographic scenario involving rapid dispersal of this species from glacial refugia in the northern hemisphere after the last glaciation.

Relationship of young-of-the-year northern pike to aquatic vegetation types in backwaters of the upper Mississippi River

USGS Publications Warehouse

Holland, L.E.; Huston, M.L.

1984-01-01

The association of young-of-the-year northern pike (Esox lucius) with different aquatic plant types (e.g., submerged, emergent, floating) was studied to evaluate the impacts of a potential loss of backwaters on available fish nursery habitats in the upper Mississippi River. Eight biweekly collections were made at each of six representative lentic habitats in Navigation Pool 7. In the spring, average catches of northern pike from areas with submerged vegetation were nearly three times greater than from areas with emergent vegetation, and more than 10 times greater than from an area with no vegetation. This pattern was consistent until late summer, when the young became more common in the more highly oxygenated, less heavily vegetated waters. Food and growth were examined as possible indicators for the selection of areas with submerged vegetation over other habitats. Food varied among fish in the different vegetation types; however, no significant patterns of improved growth or condition were apparent. Young northern pike apparently were successful, opportunistic feeders. Although preference for habitats with submerged vegetation was seemingly not related to food, the overall production of young was clearly best in these habitats.

Mineralogy and provenance of clays in miarolitic cavities of the Pikes Peak Batholith, Colorado

USGS Publications Warehouse

Kile, D.E.

2005-01-01

Clay samples from 105 cavities within miarolitic granitic pegmatites throughout the Pikes Peak batholith, in Colorado, were analyzed by powder X-ray diffraction (XRD). Smectite (beidellite), illite, and kaolinite were found within the cavities. Calculation of crystallite-thickness distribution (CTD), mean thickness of the crystallites, and variance in crystallite thickness, as deduced from XRD patterns, allowed a determination of provenance and mode of formation for illite and smectite. Authigenic miarolitic-cavity illite and smectite show lognormal CTDs and larger mean thicknesses of crystallites than do their soil-derived counterparts; non-lognormal illite in a cavity results from mixing of cavity and soil illite. Analysis of mean thickness and thickness variance shows that crystal growth of illite is initiated by a nucleation event of short duration, followed by surface-controlled kinetics. Crystallization of the miarolitic cavity clays is presumed to occur by neoformation from hydrothermal fluids. The assessment of provenance allows a determination of regional and local distributions of clay minerals in miarolitic cavities within the Pikes Peak batholith.

Baseline assessment of groundwater quality in Pike County, Pennsylvania, 2015

USGS Publications Warehouse

Senior, Lisa A.; Cravotta, Charles A.

2017-12-29

The Devonian-age Marcellus Shale and the Ordovician-age Utica Shale, which have the potential for natural gas development, underlie Pike County and neighboring counties in northeastern Pennsylvania. In 2015, the U.S. Geological Survey, in cooperation with the Pike County Conservation District, conducted a study that expanded on a previous more limited 2012 study to assess baseline shallow groundwater quality in bedrock aquifers in Pike County prior to possible extensive shale-gas development. Seventy-nine water wells ranging in depths from 80 to 610 feet were sampled during June through September 2015 to provide data on the presence of methane and other aspects of existing groundwater quality in the various bedrock geologic units throughout the county, including concentrations of inorganic constituents commonly present at low values in shallow, fresh groundwater but elevated in brines associated with fluids extracted from geologic formations during shale-gas development. All groundwater samples collected in 2015 were analyzed for bacteria, dissolved and total major ions, nutrients, selected dissolved and total inorganic trace constituents (including metals and other elements), radon-222, gross alpha- and gross beta-particle activity, dissolved gases (methane, ethane, and propane), and, if sufficient methane was present, the isotopic composition of methane. Additionally, samples from 20 wells distributed throughout the county were analyzed for selected man-made volatile organic compounds, and samples from 13 wells where waters had detectable gross alpha activity were analyzed for radium-226 on the basis of relatively elevated gross alpha-particle activity.Results of the 2015 study show that groundwater quality generally met most drinking-water standards for constituents and properties included in analyses, but groundwater samples from some wells had one or more constituents or properties, including arsenic, iron, manganese, pH, bacteria, sodium, chloride, sulfate

Clinico-pathological Correlation of Thyroid Nodule Ultrasound and Cytology Using the TIRADS and Bethesda Classifications.

PubMed

Singaporewalla, R M; Hwee, J; Lang, T U; Desai, V

2017-07-01

Clinico-pathological correlation of thyroid nodules is not routinely performed as until recently there was no objective classification system for reporting thyroid nodules on ultrasound. We compared the Thyroid Imaging Reporting and Data System (TIRADS) of classifying thyroid nodules on ultrasound with the findings on fine-needle aspiration cytology (FNAC) reported using the Bethesda System. A retrospective analysis of 100 consecutive cases over 1 year (Jan-Dec 2015) was performed comparing single-surgeon-performed bedside thyroid nodule ultrasound findings based on the TIRADS classification to the FNAC report based on the Bethesda Classification. TIRADS 1 (normal thyroid gland) and biopsy-proven malignancy referred by other clinicians were excluded. Benign-appearing nodules were reported as TIRADS 2 and 3. Indeterminate or suspected follicular lesions were reported as TIRADS 4, and malignant-appearing nodules were classified as TIRADS 5 during surgeon-performed bedside ultrasound. All the nodules were subjected to ultrasound-guided FNAC, and TIRADS findings were compared to Bethesda FNAC Classification. Of the 100 cases, 74 were considered benign or probably benign, 20 were suspicious for malignancy, and 6 were indeterminate on ultrasound. Overall concordance rate with FNAC was 83% with sensitivity and specificity of 70.6 and 90.4%, respectively. The negative predictive value was 93.8%. It is essential for clinicians performing bedside ultrasound thyroid and guided FNAC to document their sonographic impression of the nodule in an objective fashion using the TIRADS classification and correlate with the gold standard cytology to improve their learning curve and audit their results.

Surface-Water Hydrology and Quality at the Pike Hill Superfund Site, Corinth, Vermont, October 2004 to December 2005

USGS Publications Warehouse

Kiah, Richard G.; Deacon, Jeffrey R.; Piatak, Nadine M.; Seal, Robert R.; Coles, James F.; Hammarstrom, Jane M.

2007-01-01

The hydrology and quality of surface water in and around the Pike Hill Brook watershed, in Corinth, Vermont, was studied from October 2004 to December 2005 by the U.S. Geological Survey in cooperation with the U.S. Environmental Protection Agency (USEPA). Pike Hill was mined intermittently for copper from 1847 to 1919 and the site is known to be contributing trace elements and acidity to Pike Hill Brook and an unnamed tributary to Cookville Brook. The site has been listed as a Superfund site since 2004. Streamflow, specific conductance, pH, and water temperature were measured continuously and monthly at three sites on Pike Hill Brook to determine the variation in these parameters over an annual cycle. Synoptic water-quality sampling was done at 10 stream sites in October 2004, April 2005, and June 2005 and at 13 stream sites in August 2005 to characterize the quality of surface water in the watershed on a seasonal and spatial basis, as well as to assess the effects of wetlands on water quality. Samples for analysis of benthic macroinvertebrate populations were collected at 11 stream sites in August 2005. Water samples were analyzed for 5 major ions and 32 trace elements. Concentrations of trace elements at sites in the Pike Hill Brook watershed exceeded USEPA National Recommended Water Quality Criteria acute and chronic toxicity standards for aluminum, iron, cadmium, copper, and zinc. Concentrations of copper exceeded the chronic criteria in an unnamed tributary to Cookville Brook in one sample. Concentrations of sulfate, calcium, aluminum, iron, cadmium, copper, and zinc decreased with distance from a site directly downstream from the mine (site 1), as a result of dilution and through sorption and precipitation of the trace elements. Maximum concentrations of aluminum, iron, cadmium, copper, and zinc were observed during spring snowmelt. Concentrations of sulfate, calcium, cadmium, copper, and zinc, and instantaneous loads of calcium and aluminum were

Malignancy Rate in Thyroid Nodules Classified as Bethesda Category III (AUS/FLUS)

PubMed Central

Ho, Allen S.; Sarti, Evan E.; Jain, Kunal S.; Wang, Hangjun; Nixon, Iain J.; Shaha, Ashok R.; Shah, Jatin P.; Kraus, Dennis H.; Ghossein, Ronald; Fish, Stephanie A.; Wong, Richard J.; Lin, Oscar

2014-01-01

Background: The Bethesda System for Reporting Thyroid Cytopathology is the standard for interpreting fine needle aspiration (FNA) specimens. The “atypia of undetermined significance/follicular lesion of undetermined significance” (AUS/FLUS) category, known as Bethesda Category III, has been ascribed a malignancy risk of 5–15%, but the probability of malignancy in AUS/FLUS specimens remains unclear. Our objective was to determine the risk of malignancy in thyroid FNAs categorized as AUS/FLUS at a comprehensive cancer center. Methods: The management of 541 AUS/FLUS thyroid nodule patients treated at Memorial Sloan–Kettering Cancer Center between 2008 and 2011 was analyzed. Clinical and radiologic features were examined as predictors for surgery. Target AUS/FLUS nodules were correlated with surgical pathology. Results: Of patients with an FNA initially categorized as AUS/FLUS, 64.7% (350/541) underwent immediate surgery, 17.7% (96/541) had repeat FNA, and 17.6% (95/541) were observed. Repeat FNA cytology was unsatisfactory in 5.2% (5/96), benign in 42.7% (41/96), AUS/FLUS in 38.5% (37/96), suspicious for follicular neoplasm in 5.2% (5/96), suspicious for malignancy in 4.2% (4/96), and malignant in 4.2% (4/96). Of nodules with two consecutive AUS/FLUS diagnoses that were resected, 26.3% (5/19) were malignant. Among all index AUS/FLUS nodules (triaged to surgery, repeat FNA, or observation), malignancy was confirmed on surgical pathology in 26.6% [CI 22.4–31.3]. Among AUS/FLUS nodules triaged to surgery, the malignancy rate was 37.8% [CI 33.1–42.8]. Incidental cancers were found in 22.3% of patients. On univariate logistic regression analysis, factors associated with triage to surgery were younger patient age (p<0.0001), increasing nodule size (p<0.0001), and nodule hypervascularity (p=0.032). Conclusions: In patients presenting to a comprehensive cancer center, malignancy rates in nodules with AUS/FLUS cytology are higher than previously estimated, with 26

Groundwater-Quality Assessment, Pike County, Pennsylvania, 2007

USGS Publications Warehouse

Senior, Lisa A.

2009-01-01

Pike County, a 545 square-mile area in northeastern Pennsylvania, has experienced the largest relative population growth of any county in the state from 1990 to 2000 and its population is projected to grow substantially through 2025. This growing population may result in added dependence and stresses on water resources, including the potential to reduce the quantity and degrade the quality of groundwater and associated stream base flow with changing land use. Groundwater is the main source of drinking water in the county and is derived primarily from fractured-rock aquifers (shales, siltstones, and sandstones) and some unconsolidated glacial deposits that are recharged locally from precipitation. The principal land uses in the county as of 2005 were public, residential, agricultural, hunt club/private recreational, roads, and commercial. The public lands cover a third of the county and include national park, state park, and other state lands, much of which are forested. Individual on-site wells and wastewater disposal are common in many residential areas. In 2007, the U.S. Geological Survey, in cooperation with the Pike County Conservation District, began a study to provide current information on groundwater quality throughout the county that will be helpful for water-resource planning. The countywide reconnaissance assessment of groundwater quality documents current conditions with existing land uses and may serve as a baseline of groundwater quality for future comparison. Twenty wells were sampled in 2007 throughout Pike County to represent groundwater quality in the principal land uses (commercial, high-density and moderate-density residential with on-site wastewater disposal, residential in a sewered area, pre-development, and undeveloped) and geologic units (five fractured-rock aquifers and one glacial unconsolidated aquifer). Analyses selected for the groundwater samples were intended to identify naturally occurring constituents from the aquifer or

Assessment of the water balance over France using regionalized Turc-Pike formula

NASA Astrophysics Data System (ADS)

Le Lay, Matthieu; Garçon, Rémy; Gailhard, Joël; Garavaglia, Federico

2016-04-01

With extensive use of hydrological models over a wide range of hydro-climatic contexts, bias in hydro-climatic data may lead to unreliable models and thus hydrological forecasts and projections. This issue is particularly pregnant when considering mountainous areas with great uncertainties on precipitations, or when considering complex unconservative catchments (e.g. karstic systems). The Turc-Pike water balance formula, analogous to the classical Budyko formula, is a simple and efficient mathematical formulation relating long-term average streamflow to long-term average precipitation and potential evaporation. In this study, we propose to apply this framework to assess and eventually adjust the water-balance before calibrating an operational hydrologic model (MORDOR model). Considering a large set of 350 french catchments, the Turc-Pike formula is regionalized based on ecohydrologic criterions to handle various hydro-climatic contexts. This interannual regional model is then applied to assess the water-balance over numerous catchments and various conditions, such as karstic, snow-driven or glaciarized and even anthropized catchments. Results show that it is possible to obtain pretty realistic corrections of meteorological inputs (precipitations, temperature or potential evaporation) or hydrologic surface (or runoff). These corrections can often be confirmed a posteriori by exogenous information. Positive impacts on hydrologic model's calibration are also demonstrated. This methodology is now operational for hydrologic applications at EDF (Electricité de France, French electric utility company), and therefore applied on hundreds of catchments.

Visual pigment molecular evolution in the Trinidadian pike cichlid (Crenicichla frenata): a less colorful world for neotropical cichlids?

PubMed

Weadick, Cameron J; Loew, Ellis R; Rodd, F Helen; Chang, Belinda S W

2012-10-01

The Trinidadian pike cichlid (Crenicichla frenata) is a major predator of the guppy (Poecilia reticulata), a model system for visual ecology research, and visual predation by the pike cichlid is known to select for male guppies with reduced short-wavelength reflectance. However, an early study of the pike cichlid's visual system suggested a lack of short-wavelength-sensitive cone photoreceptors, a surprising finding as many African cichlids have highly developed short-wavelength vision. In this study, we found evidence for only four expressed cone opsins (LWS, RH2a, SWS2a, and SWS2b), plus one pseudogene (RH2b). Taken together with our microspectrophotometry data, which revealed the presence of three types of cone photoreceptor, including one sensitive to short-wavelength light, this would indicate a broader spectral capacity than previously believed from earlier visual studies of this fish. Relative to the highly diverse African cichlids, however, this Neotropical cichlid appears to have a greatly reduced opsin complement, reflecting both gene loss along the Neotropical lineage (lacking functional RH2b and, possibly, SWS1 opsins) and gene duplication within the African clade (which possesses paralogous RH2aα and RH2aβ opsins). Molecular evolutionary analyses show that positive selection has shaped the SWS2b and RH1 opsins along the Neotropical lineage, which may be indicative of adaptive evolution to alter nonspectral aspects of opsin biology. These results represent the first molecular evolutionary study of visual pigments in a Neotropical cichlid and thus provide a foundation for further study of a morphologically and ecologically diverse clade that has been understudied with respect to the link between visual ecology and diversification.

Passing of northern pike and common carp through experimental barriers designed for use in wetland restoration

USGS Publications Warehouse

French, John R. P.; Wilcox, Douglas A.; Nichols, S. Jerrine

1999-01-01

Restoration plans for Metzger Marsh, a coastal wetland on the south shore of western Lake Erie, incorporated a fish-control system designed to restrict access to the wetland by large common carp (Cyprinus carpio). Ingress fish passageways in the structure contain slots into which experimental grates of varying size and shape can be placed to selectively allow entry and transfer of other large fish species while minimizing the number of common carp to be handled. We tested different sizes and shapes of grates in experimental tanks in the laboratory to determine the best design for testing in the field. We also tested northern pike (Esox lucius) because lack of access to wetland spawning habitat has greatly reduced their populations in western Lake Erie. Based on our results, vertical bar grates were chosen for installation because common carp were able to pass through circular grates smaller than body height by compressing their soft abdomens; they passed through rectangular grates on the diagonal. Vertical bar grates with 5-cm spacing that were installed across much of the control structure should limit access of common carp larger than 34 cm total length (TL) and northern pike larger than 70 cm. Vertical bar grates selected for initial field trials in the fish passageway had spacings of 5.8 and 6.6 cm, which increased access by common carp to 40 and 47 cm TL and by northern pike to 76 and 81 cm, respectively. The percentage of potential common carp biomass (fish seeking entry) that must be handled in lift baskets in the passageway increased from 0.9 to 4.8 to 15.4 with each increase in spacing between bars. Further increases in spacing would greatly increase the number of common carp that would have to be handled. The results of field testing should be useful in designing selective fish-control systems for other wetland restoration sites adjacent to large water bodies.

Predicted high-water elevations for selected flood events at the Albert Pike Recreation Area, Ouachita National Forest

Treesearch

D.A. Marion

2012-01-01

The hydraulic characteristics are determined for the June 11, 2010, flood on the Little Missouri River at the Albert Pike Recreation Area in Arkansas. These characteristics are then used to predict the high-water elevations for the 10-, 25-, 50-, and 100-year flood events in the Loop B, C, and D Campgrounds of the recreation area. The peak discharge and related...

Five Year Follow-Up of a Randomized Controlled Trial on Warming and Humidification of Insufflation Gas in Laparoscopic Colonic Surgery—Impact on Small Bowel Obstruction and Oncologic Outcomes

PubMed Central

Sammour, Tarik; Hill, Andrew G.

2015-01-01

Warming and humidification of insufflation gas has been shown to reduce adhesion formation and tumor implantation in the laboratory setting, but clinical evidence is lacking. We aimed to test the hypothesis that warming and humidification of insufflation CO2 would lead to reduced adhesion formation, and improve oncologic outcomes in laparoscopic colonic surgery. This was a 5-year follow-up of a multicenter, double-blinded, randomized, controlled trial investigating warming and humidification of insufflation gas. The study group received warmed (37°C), humidified (98%) insufflation carbon dioxide, and the control group received standard gas (19°C, 0%). All other aspects of patient care were standardized. Admissions for small bowel obstruction were recorded, as well as whether management was operative or nonoperative. Local and systemic cancer recurrence, 5-year overall survival, and cancer specific survival rates were also recorded. Eighty two patients were randomized, with 41 in each arm. Groups were well matched at baseline. There was no difference between the study and control groups in the rate of clinical small bowel obstruction (5.7% versus 0%, P 0.226); local recurrence (6.5% versus 6.1%, P 1.000); overall survival (85.7% versus 82.1%, P 0.759); or cancer-specific survival (90.3% versus 87.9%, P 1.000). Warming and humidification of insufflation CO2 in laparoscopic colonic surgery does not appear to confer a clinically significant long term benefit in terms of adhesion reduction or oncological outcomes, although a much larger randomized controlled trial (RCT) would be required to confirm this. ClinicalTrials.gov Trial identifier: NCT00642005; US National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA. PMID:25875541

Five year follow-up of a randomized controlled trial on warming and humidification of insufflation gas in laparoscopic colonic surgery--impact on small bowel obstruction and oncologic outcomes.

PubMed

Sammour, Tarik; Hill, Andrew G

2015-04-01

Warming and humidification of insufflation gas has been shown to reduce adhesion formation and tumor implantation in the laboratory setting, but clinical evidence is lacking. We aimed to test the hypothesis that warming and humidification of insufflation CO2 would lead to reduced adhesion formation, and improve oncologic outcomes in laparoscopic colonic surgery. This was a 5-year follow-up of a multicenter, double-blinded, randomized, controlled trial investigating warming and humidification of insufflation gas. The study group received warmed (37°C), humidified (98%) insufflation carbon dioxide, and the control group received standard gas (19°C, 0%). All other aspects of patient care were standardized. Admissions for small bowel obstruction were recorded, as well as whether management was operative or nonoperative. Local and systemic cancer recurrence, 5-year overall survival, and cancer specific survival rates were also recorded. Eighty two patients were randomized, with 41 in each arm. Groups were well matched at baseline. There was no difference between the study and control groups in the rate of clinical small bowel obstruction (5.7% versus 0%, P 0.226); local recurrence (6.5% versus 6.1%, P 1.000); overall survival (85.7% versus 82.1%, P 0.759); or cancer-specific survival (90.3% versus 87.9%, P 1.000). Warming and humidification of insufflation CO2 in laparoscopic colonic surgery does not appear to confer a clinically significant long term benefit in terms of adhesion reduction or oncological outcomes, although a much larger randomized controlled trial (RCT) would be required to confirm this. ClinicalTrials.gov Trial identifier: NCT00642005; US National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA.

Uptake and transport of manganese in primary and secondary olfactory neurones in pike.

PubMed

Tjälve, H; Mejàre, C; Borg-Neczak, K

1995-07-01

gamma-spectrometry and autoradiography were used to examine the axoplasmic flow of manganese in the olfactory nerves and to study the uptake of the metal in the brain after application of 54Mn2+ in the olfactory chambers of pikes. The results show that the 54Mn2+ is taken up in the olfactory receptor cells and is transported at a constant rate along the primary olfactory neurones into the brain. The maximal velocity for the transported 54Mn2+ was 2.90 +/- 0.21 mm/hr (mean +/- S.E.) at 10 degrees, which was the temperature used in the experiments. The 54Mn2+ accumulated in the entire olfactory bulbs, although most marked in central and caudal parts. The metal was also seen to migrate into large areas of the telencephalon, apparently mainly via the secondary olfactory axons present in the medial olfactory tract. A transfer along fibres of the medial olfactory tract probably also explains the labelling which was seen in the diencephalon down to the hypothalamus. The results also showed that there is a pathway connecting the two olfactory bulbs of the pike and that this can carry the metal. Our data further showed a marked accumulation of 54Mn2+ in the meningeal epithelium and in the contents of the meningeal sacs surrounding the olfactory bulbs. It appears from our study that manganese has the ability to pass the synaptic junctions between the primary and the secondary olfactory neurones in the olfactory bulbs and to migrate along secondary olfactory pathways into the telencephalon and the diencephalon.(ABSTRACT TRUNCATED AT 250 WORDS)

Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

PubMed Central

2014-01-01

A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at providing a comprehensive overview of the state of microbiome research, but more importantly to identify and discuss gaps, challenges and opportunities in this nascent field. This report summarizes the presentations but also describes what is needed for human microbiome research to move forward and deliver medical translational applications.

Two-dimensional simulation of the June 11, 2010, flood of the Little Missouri River at Albert Pike Recreational Area, Ouachita National Forest, Arkansas

USGS Publications Warehouse

Wagner, Daniel M.

2013-01-01

In the early morning hours of June 11, 2010, substantial flooding occurred at Albert Pike Recreation Area in the Ouachita National Forest of west-central Arkansas, killing 20 campers. The U.S. Forest Service needed information concerning the extent and depth of flood inundation, the water velocity, and flow paths throughout Albert Pike Recreation Area for the flood and for streamflows corresponding to annual exceedence probabilities of 1 and 2 percent. The two-dimensional flow model Fst2DH, part of the Federal Highway Administration’s Finite Element Surface-water Modeling System, and the graphical user interface Surface-water Modeling System (SMS) were used to perform a steady-state simulation of the flood in a 1.5-mile reach of the Little Missouri River at Albert Pike Recreation Area. Peak streamflows of the Little Missouri River and tributary Brier Creek served as inputs to the simulation, which was calibrated to the surveyed elevations of high-water marks left by the flood and then used to predict flooding that would result from streamflows corresponding to annual exceedence probabilities of 1 and 2 percent. The simulated extent of the June 11, 2010, flood matched the observed extent of flooding at Albert Pike Recreation Area. The mean depth of inundation in the camp areas was 8.5 feet in Area D, 7.4 feet in Area C, 3.8 feet in Areas A, B, and the Day Use Area, and 12.5 feet in Lowry’s Camp Albert Pike. The mean water velocity was 7.2 feet per second in Area D, 7.6 feet per second in Area C, 7.2 feet per second in Areas A, B, and the Day Use Area, and 7.6 feet per second in Lowry’s Camp Albert Pike. A sensitivity analysis indicated that varying the streamflow of the Little Missouri River had the greatest effect on simulated water-surface elevation, while varying the streamflow of tributary Brier Creek had the least effect. Simulated water-surface elevations were lower than those modeled by the U.S. Forest Service using the standard-step method, but the

Microbiological properties and biogenic amines of whole pike-perch (Sander lucioperca, linnaeus 1758): a perspective on fish safety during postharvest handling practices and frozen storage.

PubMed

Ehsani, Ali; Jasour, Mohammad Sedigh

2012-12-01

The biogenic amines (tyramine, histamine, cadaverine, and puterscine) and microbiological properties (mesophilic, psychrotrophic, and Pseudomonas spp.) of whole pike-perch (Sander lucioperca) was investigated during 2 d prestorage icing and 90 d frozen storage (-24 °C). At the end of ice storage, a noticeable increase only was found for puterscine level (P < 0.05), and microbial loads of fish increased in comparison with fresh fish (P < 0.05). During the frozen storage, as time passed, a continuous increase of biogenic amines and decrease of bacterial load (except for Pseudomonas spp. at the last 30 d) was detected (P < 0.05). The total contents of biogenic amines ranged from 6.24 to 91.76 μg/g during the investigated period. Puterscine was the major amine detected in pike-perch and its concentration varied between 1.75 and 56.95 μg/g; due to a more step-wise increase it was a good quality indicator. At the end of storage, all of the obtained values are below the tolerable maximum amounts based on available regulations. Based on biogenic amines content and microbial load, it could be concluded that pike-perch can be consumed without any health risks after 2 d icing condition and 90 d frozen storage. © 2012 Institute of Food Technologists®

[Implementation of cytology images classification--the Bethesda 2001 System--in a group of screened women from Podlaskie region--effect evaluation].

PubMed

Zbroch, Tomasz; Knapp, Paweł Grzegorz; Knapp, Piotr Andrzej

2007-09-01

Increasing knowledge concerning carcinogenesis within cervical epithelium has forced us to make continues modifications of cytology classification of the cervical smears. Eventually, new descriptions of the submicroscopic cytomorphological abnormalities have enabled the implementation of Bethesda System which was meant to take place of the former Papanicolaou classification although temporarily both are sometimes used simultaneously. The aim of this study was to compare results of these two classification systems in the aspect of diagnostic accuracy verified by further tests of the diagnostic algorithm for the cervical lesion evaluation. The study was conducted in the group of women selected from general population, the criteria being the place of living and cervical cancer age risk group, in the consecutive periods of mass screening in Podlaski region. The performed diagnostic tests have been based on the commonly used algorithm, as well as identical laboratory and methodological conditions. Performed assessment revealed comparable diagnostic accuracy of both analyzing classifications, verified by histological examination, although with marked higher specificity for dysplastic lesions with decreased number of HSIL results and increased diagnosis of LSILs. Higher number of performed colposcopies and biopsies were an additional consequence of TBS classification. Results based on Bethesda System made it possible to find the sources and reasons of abnormalities with much greater precision, which enabled causing agent treatment. Two evaluated cytology classification systems, although not much different, depicted higher potential of TBS and better, more effective communication between cytology laboratory and gynecologist, making reasonable implementation of The Bethesda System in the daily cytology screening work.

Time for Decisions: Visualizing the Future. Proceedings of the Annual NEAIR Conference (39th, Bethesda, Maryland, November 3-6, 2012)

ERIC Educational Resources Information Center

Carson, Cristi, Ed.

2012-01-01

The NEAIR (North East Association for Institutional Research) 2012 Conference Proceedings is a compilation of papers presented at the Bethesda, Maryland conference. Papers in this document include: (1) Can a Marketing Campaign Increase Response Rates to Online Course Evaluations? (Kimberly Puhala); (2) Developing Community College Peer…

The effects of season on fatty acid composition and ω3/ω6 ratios of northern pike ( Esox lucius L., 1758) muscle lipids

NASA Astrophysics Data System (ADS)

Mert, Ramazan; Bulut, Sait; Konuk, Muhsin

2015-01-01

In the present study, the effects of season on fatty acid composition, total lipids, and ω3/ω6 ratios of northern pike muscle lipids in Kizilirmak River (Kirikkale, Turkey) were investigated. A total of 35 different fatty acids were determined in gas chromatography. Among these, palmitic, oleic, and palmitoleic acids had the highest proportion. The main polyunsaturated fatty acids (PUFAs) were found to be docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid. There were more PUFAs than monounsaturated fatty acids (MUFA) in all seasons. Similarly, the percentages of ω3 fatty acids were higher than those of total ω6 fatty acids in the fatty acid composition. ω3/ω6 ratios were calculated as 1.53, 1.32, 1.97, and 1.71 in spring, summer, autumn and winter, respectively. Overall, we found that the fatty acid composition and ω3/ω6 fatty acid ratio in the muscle of northern pike were significantly influenced by season.

mGluR5 stimulating Homer–PIKE formation initiates icariin induced cardiomyogenesis of mouse embryonic stem cells by activating reactive oxygen species

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Limin; Huang, Yujie; Zhang, Yingying

2013-06-10

Icariin (ICA) has been reported to facilitate cardiac differentiation of mouse embryonic stem (ES) cells; however, the mechanism by which ICA induced cardiomyogenesis has not been fully elucidated yet. Here, an underlying signaling network including metabotropic glutamate receptor 5 (mGluR5), Homer, phosphatidylinositol 3-Kinase Enhancer (PIKE), phosphatidylinositol 3-Kinase (PI3K), reactive oxygen species (ROS) and nuclear factor-kappaB (NF-κB) was investigated in ICA induced cardiomyogenesis. Our results showed that the co-expression of mGluR5 together with α-actinin or Troponin T in embryoid bodies (EBs) treated with ICA was elevated to 10.86% and 9.62%, compared with the case in the control (4.04% and 3.45%, respectively).more » Exposure of EBs to ICA for 2 h remarkably increased the dimeric form of mGluR5, which was inhibited by small interfering RNA targeting mGluR5 (si-mGluR5). Moreover, the extracellular glutamate concentration in ICA treatment medium was elevated to 28.9±3.5 μM. Furthermore, the activation of mGluR5 by ICA triggered the formation of Homer–PIKE complex and activated PI3K, stimulating ROS generation and NF-κB nuclear translocation. Knockdown of mGluR5 or inhibition of PI3K by LY294002 blocked ICA induced cardiomyogenesis via repressing mGluR5 pathway, reducing ROS and NF-κB activation. These results revealed that the inducible mechanisms of ICA were related to activate mGluR5 pathway. -- Highlights: • ICA increased mGluR5 expression in cardiac differentiation of ES cells. • ICA enhanced the glutamate level and the receptor mGluR5 dimerization, stimulating the formation of Homer–PIKE complex. • Knockdown of mGluR5 or inhibition of PI3K by LY294002 inhibited ICA induced ROS generation and NF-κB nuclear translocation.« less

A ribonuclease protection assay can distinguish spring viremia of carp virus from pike fry rhabdovirus

USGS Publications Warehouse

Ahne, W.; Kurath, G.; Winton, J.R.

1998-01-01

Thirteen rhabdovirus isolates from 10 teleost fish species as well as reference strains of spring viraemia of carp virus (SVCV) and pike fry rhabdovirus (PFRV) cross-reacted in an indirect immunofluorescence assay and were thus indistinguishable by this method. A ribonuclease protection assay (RPA) using a super(32)P-labeled RNA probe made from a cloned copy of the full length SVCV glycoprotein (G) gene was able to discriminate clearly between the type strains of SVCV and PFRV and among the 13 rhabdovirus isolates. Results for the RPA were generally in agreement with standard serum neutralisation assays; however, the RPA was also able to detect genomic differences between isolates of SVCV. These results have implications for fish disease control programs for SVCV.

Geochemical Characterization of Mine Waste, Mine Drainage, and Stream Sediments at the Pike Hill Copper Mine Superfund Site, Orange County, Vermont

USGS Publications Warehouse

Piatak, Nadine M.; Seal, Robert R.; Hammarstrom, Jane M.; Kiah, Richard G.; Deacon, Jeffrey R.; Adams, Monique; Anthony, Michael W.; Briggs, Paul H.; Jackson, John C.

2006-01-01

The Pike Hill Copper Mine Superfund Site in the Vermont copper belt consists of the abandoned Smith, Eureka, and Union mines, all of which exploited Besshi-type massive sulfide deposits. The site was listed on the U.S. Environmental Protection Agency (USEPA) National Priorities List in 2004 due to aquatic ecosystem impacts. This study was intended to be a precursor to a formal remedial investigation by the USEPA, and it focused on the characterization of mine waste, mine drainage, and stream sediments. A related study investigated the effects of the mine drainage on downstream surface waters. The potential for mine waste and drainage to have an adverse impact on aquatic ecosystems, on drinking- water supplies, and to human health was assessed on the basis of mineralogy, chemical concentrations, acid generation, and potential for metals to be leached from mine waste and soils. The results were compared to those from analyses of other Vermont copper belt Superfund sites, the Elizabeth Mine and Ely Copper Mine, to evaluate if the waste material at the Pike Hill Copper Mine was sufficiently similar to that of the other mine sites that USEPA can streamline the evaluation of remediation technologies. Mine-waste samples consisted of oxidized and unoxidized sulfidic ore and waste rock, and flotation-mill tailings. These samples contained as much as 16 weight percent sulfides that included chalcopyrite, pyrite, pyrrhotite, and sphalerite. During oxidation, sulfides weather and may release potentially toxic trace elements and may produce acid. In addition, soluble efflorescent sulfate salts were identified at the mines; during rain events, the dissolution of these salts contributes acid and metals to receiving waters. Mine waste contained concentrations of cadmium, copper, and iron that exceeded USEPA Preliminary Remediation Goals. The concentrations of selenium in mine waste were higher than the average composition of eastern United States soils. Most mine waste was

[On-site fine-needle aspiration cytology of thyroid nodules. Quality assurance of the Bethesda System for Reporting Thyroid Cytopathology (2008)].

PubMed

Bak, Mihály; Péter, Ilona; Nyári, Tibor; Simon, Péter; Újlaky, Mátyás; Boér, András; Kásler, Miklós

2015-10-11

The methods available for the diagnosis of thyroid nodules include physical examination, imaging, laboratory and fine-needle aspiration cytology tests. The aim of this study was to determine the quality assurance of fine-needle aspiration cytology of thyroid nodules. Cytology results were rated to 6 categories according to the Bethesda System for Reporting Thyroid Cytopathology (2008) (I. nondiagnostic; II. benign; III. atypia of undetermined significance; IV. follicular neoplasia; V. suspicious for malignancy; VI. malignant). All cytology reports were compared with the final histology diagnosis. A total of 1384 patient with thyroid nodule underwent fine-needle aspiration biopsy cytology. Smears were classified I. inadequate in 214 (15.9%); II. benign 986; III. atypical 56; IV. follicular neoplasm 41; V. suspicious for malignancy 18; VI. malignant 33 cases. Two hundred and twenty seven (16.8%) of the cases were operated and histologically verified. The positive predictive value in the benign category was 98.25% and in the malignant 88.46%. The sensitivity of the follicular neoplasm was 66.67%. The results suggest that fine-needle aspiration cytology of thyroid nodules using the Bethesda System for Reporting Thyroid Cytopathology has a high diagnostic accuracy. The auditing values of the results meet the proposed threshold values.

Suggested nomenclature change and new reference locality for Dequeen Formation, Pike County, Arkansas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ham, T.L.; Landry, R.J.

1983-09-01

The DeQueen Formation of the Trinity Group, Comanchean Cretaceous, crops out in southwestern Arkansas and southeastern Oklahoma. The outcrop, located in the Highland gypsum quarry of Pike County, southwestern Arkansas, is described in detail in this paper and presented as a reference locality. Data from the locality provide the basis for a nomenclature change from the DeQueen Limestone Member to the DeQueen Formation. The formation consists of 64.23% clastic sediments, 24.72% gypsum, and 11.05% limestone. Hopper salt casts, ripple marks, scattered pyrite and marcasite nodules, celestite, and chickenwire gypsum can also be found. The DeQueen Formation is underlain by claysmore » and the Ultima Thule Gravel lentil, while the top is unconformably overlain by Upper Cretaceous Tokio gravels. The general paleoenvironment represents a normally low-energy subtidal environment ranging from brackish to normal to hypersaline waters in a lagoonal setting that shallows upward.« less

Presence and Formation Mechanism of Foodborne Carbonaceous Nanostructures from Roasted Pike Eel ( Muraenesox cinereus).

PubMed

Bi, Jingran; Li, Yao; Wang, Haitao; Song, Yukun; Cong, Shuang; Yu, Chenxu; Zhu, Bei-Wei; Tan, Mingqian

2018-03-21

Foodborne nanostructures have gained more and more attention in recent years. In this paper, the presence and physicochemical properties of carbonaceous nanostructures (CNSs) from roasted pike eel ( Muraenesox cinereus) were reported. The monodispersed CNSs are strongly photoluminescent under the illustration of ultraviolet (UV) light, with a fluorescent quantum yield of 80.16%, and display excitation-dependent emission behavior. The formation of CNSs is believed to go through a process of morphology evolution, including polymerization, pyrolysis, nucleation, growth, emergence, and blossom. The optical properties of the CNSs were shown to be affected by the roasting temperature. Furthermore, cellular uptake of the CNSs was investigated, and it is shown that the CNSs were clearly absorbed into live cells and were mainly distributed within the cell cytoplasm and not in the cell nucleus. This work is among the very first reports on CNSs present in roasted fish, providing valuable insights into the formation mechanism of such nanostructures and showcasing the biodistribution of these food-originated CNSs in live cells.

National Dam Safety Program. Bowling Green Dam, (MO 10262) Mississippi - Kaskaskia - St. Louis Basin, Pike County, Missouri. Phase I Inspection Report.

DTIC Science & Technology

1978-12-01

4 L-7 hiI<±b fd .rvc~ a .3",d,! i:; ba ’-ii~ y :nztructl~n :).L a -- flattctod r~-%3 i Pazo u-3 and r.). 1yzj. f r 3n- the road-rmy, S11eet 13...Program " Final Report Bowling Green Reservoir Dam (MO 10262) 6. PERFORMING-ORG. REPORT NUMBER Pike County, Missouri 7. AUTHOR( a ) S. CONTRACT OR GRANT...if possible. If a classification is required, identify the classified items on the page by the appropriate symbol. CC; -ETION GUIDE General. Make

Micas from the Pikes Peak batholith and its cogenetic granitic pegmatites, Colorado: Optical properties, composition, and correlation with pegmatite evolution

USGS Publications Warehouse

Kile, D.E.; Foord, E.E.

1998-01-01

Optical properties are presented for 66 samples of mica covering the range from annite ??? biotite ??? zinnwaldite ??? ferroan lepidolite and ferroan muscovite from occurrences of granitic pegmatite (NYF type) throughout the Pikes Peak batholith (PPB) in Colorado. Chemical composition was determined for 34 of these samples. The optical data are correlated with composition, mode of occurrence, and relation to pegmatite paragenesis. Optical properties of the trioctahedral micas show a consistent trend of decreasing ?? index of refraction, from an average of 1.693 in annite of the host granite to 1.577 in zinnwaldite and ferroan lepidolite of the miarolitic cavities, which correlates with a progressively decreasing content of Fe. A comparison of optical and compositional data for micas from localities throughout the PPB indicates a variation in geochemical evolution among pegmatites of different districts, and between the Pikes Peak Granite and its late satellite plutons. Analyses of mica samples taken from cross-sections through individual pegmatites reveal a decrease in index of refraction and total iron that unambiguously document a progressive geochemical evolution within a given pegmatite. Such data, in addition to field evidence, indicate that micas enclosed within massive quartz are paragenetically older than those within miarolitic cavities; minerals within miarolitic cavities represent the final stages of primary crystallization. A general model of pegmatite paragenesis is proposed that hypothesizes formation of miarolitic cavities as a consequence of pegmatite configuration and inclination, as well as early crystallization of massive quartz that confines the silicate melt and volatile phase, resulting in closed-system crystallization with a concomitant increase in pressure, consequent episodic cavity-rupture events, and corresponding changes in mica composition.

The Bethesda system for reporting thyroid cytopathology in Colombia: Correlation with histopathological diagnoses in oncology and non-oncology institutions

PubMed Central

Melo-Uribe, Mario Alexander; Sanabria, Álvaro; Romero-Rojas, Alfredo; Pérez, Gabriel; Vargas, Elga Johanna; Abaúnza, María Claudia; Gutiérrez, Víctor

2015-01-01

Aim: To determine the correlation between the results of thyroid fine-needle aspirations interpreted using the Bethesda system and final histopathological reports for patients at an oncology hospital (OH) and non-oncology hospitals (NOHs). Materials and Methods: A retrospective, cross-sectional, descriptive study was performed to compare the cytology and histopathology results for patients with thyroid nodules in three Colombian hospitals. The final correlation of diagnoses between the two methods is reported. In Colombia, the health system provides the existence of general care hospitals and hospitals specializing in care of patients with cancer. Results: A total of 196 reports were reviewed, of which 53% were from OH and 47% were from NOHs. A greater proportion of category V (37.5%) was diagnosed at the OH, whereas NOHs diagnosed a greater proportion of category II (42.3%). The global correlation between diagnoses made using cytology and histopathology was 93.3% for categories V and VI (based on the final malignant diagnosis) and 86.9% for benign category II. Significant differences between institution types were observed when category IV and V and malignant histopathology were compared (56.3% OH vs. 23.5% NOH; P = 0.05 for category IV, 97.4% OH vs. 82.3% NOH; P = 0.03 for category V), while no significant difference between institution types was observed when category II and final benign diagnosis were compared (P = 0.6). Conclusions: The Bethesda system for thyroid cytology correlates adequately with final histopathological diagnosis in Colombia. Significant differences were identified in the diagnostic correlation for malignant lesions between the OH and NOHs in categories IV and V caused by selection bias of the population. PMID:25948937

Introduction of the Bethesda System to Mainland China with a Web-based tutorial.

PubMed

Yuan, Qin; Chang, Alexander Russell; Ng, Ho Keung

2003-01-01

To validate the use of a Web-based tutorial to introduce the Bethesda System (TBS) to Mainland Chinese laboratories. Digitized color images of the diagnostic features in 20 Pap smears were displayed on a Web page. Participants were asked to give each smear a diagnosis using the reporting nomenclature employed in their laboratory or one that was familiar to them. This was followed by teaching images of each smear accompanied by text in English and Chinese that highlighted important features for making a diagnosis using TBS. Participants then reviewed the 20 original Pap smears and rendered a diagnosis using TBS. Pathologists and cytotechnologists at 17 laboratories located in 10 cities completed the exercise. The average diagnostic accuracy for the 20 Pap smears before and after the tutorial was 76% and 88%, respectively. Web-based tutorials can be used for disseminating cytologic information to widely dispersed laboratories in China and help enhance the practice of cytology, currently an underutilized diagnostic technique. However, such difficulties as lack of Internet connections in the laboratory, outdated computers and a lack of interest in cytology need to be overcome to ensure success.

Geochemistry, petrology, and palynology of the Pond Creek coal bed, northern Pike and southern Martin counties, Kentucky

USGS Publications Warehouse

Hower, J.C.; Ruppert, L.F.; Eble, C.F.; Clark, W.L.

2005-01-01

The geochemistry, petrology, and palynology of the Duckmantian-age Pond Creek coal bed were investigated in northern Pike and southern Martin counties, eastern Kentucky. The coal bed exhibits significant vertical variation in the investigated geochemical parameters, with many diagenetic overprints of the original geochemistry. Included in the range of geochemical signatures are the presence of elements, particularly TiO2 and Zr, suggesting the detrital influences at the time of deposition of a low-vitrinite durain; a high CaO zone with elevated B/Be, both suggesting marine influence, in a lithotype in the middle of the coal bed; and the postdepositional emplacement of pyrite in the uppermost lithotype. Individual lithotypes, each representing distinct depositional environments, all complicated to some degree by diagentic overprints, comprise the complex history of the coal bed. ?? 2004 Elsevier B.V. All rights reserved.

Citizen science data suggest that a novel rig improves landing rate and reduces injury and handling time in recreational angling with artificial lures in Baltic pike (Esox lucius).

PubMed

Bursell, Jens Jakob; Arlinghaus, Robert

2018-01-01

The optimal terminal gear in hook-and-line recreational fishing maximizes landing rates and minimizes injury to the fish because some fish will be released after capture. We designed a novel rig configuration in artificial lure fishing for top predators and examined its effectiveness in angling for Baltic northern pike ( Esox lucius ) using a citizen science approach based on observational data collected from volunteer anglers in the field. The novel rig included two changes to traditional rig designs common to artificial lure angling. First, hooks were mounted in a way giving better hook exposure and eliminating lever-arm effects from the lure to the hooks once a fish is hooked. This construction allowed the second change, being a shift to hooks 4-5 sizes smaller than those used on traditional hook mounts. We analysed observational data collected by volunteer anglers using either the novel rig or a standard rig mount in two types of artificial lures (softbait and hardbait) of the same size (about 17 cm). Using N  = 768 pike contacts as input data, we showed the landing rates of pike targeted with artificial lures significantly and substantially increased from 45% with normal-rigs to 85% when the same lure types were fished with the novel rig configuration. Lure type and water temperature had no effects on landing rates. Moreover, hardbaits on normal-rigs produced significantly more injury, bleeding and elevated unhooking time compared to fish captured on hardbaits with release-rigs. We conclude that simple changes to traditional hook sizes and mounts in lure fishing may benefit both anglers and the fishes that are to be released and that citizen science projects with volunteer anglers are able to provide good data in proof-of-concept studies. Further experimental studies are needed to differentiate hook size from hook mount effects because both variables were confounded in the results of the observational data presented here.

Huffmanela hamo sp. n. (Nematoda: Trichosomoididae: Huffmanelinae) from the dagger-tooth pike conger Muraenesox cinereus off Japan.

PubMed

Justine, Jean-Lou; Iwaki, Takashi

2014-06-01

Huffmanela hamo sp. n. is described from eggs only, which were found in black spots in the somatic musculature of a dagger-tooth pike conger, Muraenesox cinereus (Forsskål), caught off Japan. The eggs are 66-77 microm (mean 72 microm) in length and 33-38 microm (mean 35 microm) in width. The surface of the eggs is smooth and bears neither envelope nor filaments. The species is distinguished from other members of the genus by the dimensions of its eggs and the characteristics of their surface. This is the first species of Huffmanela Moravec, 1987 to be described from an anguilliform fish, and the twentieth nominal species in the genus. Similar black spots with eggs were reported four times in ten years from this fish caught off Japan; although eggs could not be examined, it is likely that the same species was involved in all cases.

2006 Bethesda International Consensus recommendations on the immunophenotypic analysis of hematolymphoid neoplasia by flow cytometry: optimal reagents and reporting for the flow cytometric diagnosis of hematopoietic neoplasia.

PubMed

Wood, Brent L; Arroz, Maria; Barnett, David; DiGiuseppe, Joseph; Greig, Bruce; Kussick, Steven J; Oldaker, Teri; Shenkin, Mark; Stone, Elizabeth; Wallace, Paul

2007-01-01

Immunophenotyping by flow cytometry has become standard practice in the evaluation and monitoring of patients with hematopoietic neoplasia. However, despite its widespread use, considerable variability continues to exist in the reagents used for evaluation and the format in which results are reported. As part of the 2006 Bethesda Consensus conference, a committee was formed to attempt to define a consensus set of reagents suitable for general use in the diagnosis and monitoring of hematopoietic neoplasms. The committee included laboratory professionals from private, public, and university hospitals as well as large reference laboratories that routinely operate clinical flow cytometry laboratories with an emphasis on lymphoma and leukemia immunophenotyping. A survey of participants successfully identified the cell lineage(s) to be evaluated for each of a variety of specific medical indications and defined a set of consensus reagents suitable for the initial evaluation of each cell lineage. Elements to be included in the reporting of clinical flow cytometric results for leukemia and lymphoma evaluation were also refined and are comprehensively listed. The 2006 Bethesda Consensus conference represents the first successful attempt to define a set of consensus reagents suitable for the initial evaluation of hematopoietic neoplasia. Copyright 2007 Clinical Cytometry Society.

Recommendations for a barrier island breach management plan for Fire Island National Seashore, including the Otis Pike High Dune Wilderness Area, Long Island, New York

USGS Publications Warehouse

Williams, S. Jeffress; Foley, Mary K.

2007-01-01

4. Economic costs and benefits of artificial closure. This report for breach management presents protocols which specify when breach closures within the FIIS might be desirable and necessary, as well as provides recommendations for structural breach closure engineering operations which are indented to minimize negative impacts to the natural wilderness values and cultural resources within the FIIS, particularly the Otis Pike Wilderness Area. The goal of the plan is to strike a balance between protecting natural resources and allowing natural processes to operate and avoiding loss of life and excessive property damage.

Multimodal assessment of visual attention using the Bethesda Eye & Attention Measure (BEAM).

PubMed

Ettenhofer, Mark L; Hershaw, Jamie N; Barry, David M

2016-01-01

Computerized cognitive tests measuring manual response time (RT) and errors are often used in the assessment of visual attention. Evidence suggests that saccadic RT and errors may also provide valuable information about attention. This study was conducted to examine a novel approach to multimodal assessment of visual attention incorporating concurrent measurements of saccadic eye movements and manual responses. A computerized cognitive task, the Bethesda Eye & Attention Measure (BEAM) v.34, was designed to evaluate key attention networks through concurrent measurement of saccadic and manual RT and inhibition errors. Results from a community sample of n = 54 adults were analyzed to examine effects of BEAM attention cues on manual and saccadic RT and inhibition errors, internal reliability of BEAM metrics, relationships between parallel saccadic and manual metrics, and relationships of BEAM metrics to demographic characteristics. Effects of BEAM attention cues (alerting, orienting, interference, gap, and no-go signals) were consistent with previous literature examining key attention processes. However, corresponding saccadic and manual measurements were weakly related to each other, and only manual measurements were related to estimated verbal intelligence or years of education. This study provides preliminary support for the feasibility of multimodal assessment of visual attention using the BEAM. Results suggest that BEAM saccadic and manual metrics provide divergent measurements. Additional research will be needed to obtain comprehensive normative data, to cross-validate BEAM measurements with other indicators of neural and cognitive function, and to evaluate the utility of these metrics within clinical populations of interest.

Implementation of the Bethesda System for Reporting Thyroid Cytopathology: observations from the 2011 thyroid supplemental questionnaire of the College of American Pathologists.

PubMed

Auger, Manon; Nayar, Ritu; Khalbuss, Walid E; Barkan, Güliz A; Benedict, Cynthia C; Tambouret, Rosemary; Schwartz, Mary R; Howell, Lydia P; Souers, Rhona J; Hartley, David A; Thomas, Nicole; Moriarty, Ann T

2013-11-01

Although information about the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has been widely disseminated since its inception in 2007, the extent of its implementation and impact on daily practice has not been formally evaluated. To assess the extent of uptake of TBSRTC across pathology laboratories and to evaluate its impact on daily practice by collating participant responses to the 2011 supplemental thyroid questionnaire of the College of American Pathologists. A questionnaire was designed to gather information about various aspects of TBSRTC and mailed in June 2011 to 2063 laboratories participating in the College of American Pathologists cytopathology interlaboratory comparison program. The participating laboratories' answers were collated and summarized. Seven hundred and seventy-seven laboratories (37.6%) returned the survey. Although 60.9% (n = 451) and 17.1% (n = 127) of laboratories reported using TBSRTC or planning to use it in the near future, respectively, 22% (n = 163) had no plans to implement TBSRTC. Of the latter, 32% (n = 70) stated that they were unaware of this classification system. The majority (78.3%, n = 343) of the laboratories used TBSRTC as published in the Thyroid Bethesda System atlas, whereas 21.7% (n = 95) used it with minor modifications. Most reported that the use of TBSRTC had caused either no change (n = 67, 15.2%) or only minor changes (n = 353, 80.2%) in the terminology and diagnostic criteria previously used in their laboratories. According to the collected data, TBSRTC is generally well implemented in pathology laboratories. However, because approximately a third of those not using this terminology are not aware of it, additional educational efforts regarding TBSRTC are warranted.

[Atypical urothelial cells (AUC): A Bethesda-derived wording applicable to urinary cytopathology].

PubMed

Piaton, Eric; Advenier, Anne-Sophie; Benaïm, Gilles; Petrucci, Myriam Decaussin; Lechevallier, Florence Mege; Ruffion, Alain

2011-02-01

To investigate (1) whether sparse nuclear atypias involving deep urothelial cells have a diagnostic or prognostic value in urinary cytology, and (2) whether the terms atypical urothelial cells "of undetermined significance" (AUC-US) or "cannot exclude high grade" (AUC-H) might be used to standardize urinary cytology reports. Atypical urothelial cells (AUC) were defined as deep cells with nuclear abnormalities (increased N/C ratio, eccentric nucleus, hyperchromatism and/or irregular shape) in small number not allowing their categorization as malignant, high grade. We studied 435 urinary samples from 126 patients with AUC at any step of their clinical history, followed up over a 10-year period (1999-2009). Every case was compared with histopathology within 6 months and to long term follow-up including cystoscopy and histopathology combined. A total of 183 AUC was recorded. AUC were associated with negative, benign or low grade histological results in 36 of 106 cases (33.9 %) within 6 months, but a high grade was simultaneously documented in 70 cases (66 %). AUC preceded high-grade lesions in 66 cases (36.1 % of all AUC) in a mean interval of 10.5±12.0 months. Overall, AUC were associated with or predictive of high-grade lesions in 135 cases (73.8 %). AUC have a diagnostic and prognostic value. Applying the terms AUC-US and AUC-H to urinary cytopathology reports would allow, as for the Bethesda system for cervical or vaginal cytologic diagnoses, better appreciation of the risk of progression to high grade tumours in cases with atypias. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

Ultrasound guided FNA of thyroid performed by cytopathologists enhances Bethesda diagnostic value.

PubMed

Wu, Maoxin; Choi, YoonSun; Zhang, Zesong; Si, Quisheng; Salem, Fadi; Szporn, Arnold; Zhang, David; Burstein, David; Teng, Marita; Miles, Brett A; Genden, Eric

2016-10-01

Ultrasound (US) guided fine needle aspiration (FNA) biopsy of thyroid are examined and reported by cytopathologists based usually on The Bethesda System for Reporting Thyroid Cytopathology (BTC) regardless of the procedure's performers. This study is designed to determine whether there is any performer-dependent difference. Six hundred and fifty-one thyroid US-FNAs in correlation with surgical follow-up (SFU) were studied. The statistical analysis was performed using the surgical pathology diagnosis as the gold standard. Among the 283 cases performed by cytopathologists, there were 8 (2.8%) nondiagnostic (BTC I), 197 (69.6%) benign (BTC II), 31 (11%) atypical (BTC III), 14 (5%) suspicious for follicular neoplasm (BTC IV), 12 (4.2%) suspicious for malignancy (BTC V), and 21 (7.4%) positive for malignancy (BTC VI), and there were 55 (19.4%) cases with SFU. The 368 cases performed by others showed 76 (21%) BTC I, 238 (65%) BTC II, 26 (7%) BTC III, 10 (3%) BTC IV, 9 (2.5%) BTC V 5, and 9 (2.5%) BTC VI, and there were 26 (7%) cases with SFU. The cytopathologist group achieved better sensitivity (91.3 vs.78%); slightly better specificity (83.3 vs. 82%); better positive predictive value (87.5 vs. 70%); similar negative predictive value (88.2 vs. 88%); and better overall accuracy (87.8 vs. 81%) compared with the non-cytopathologist group. Overall the difference for all statistical values is significant different (P = 0.041). US-FNA performed by cytopathologists showed a lower unsatisfactory rate and significantly better overall statistical values. Cytopathologists may play an important role in thyroid patient care. Diagn. Cytopathol. 2016;44:787-791. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Phylogenomics of pike cichlids (Cichlidae: Crenicichla): the rapid ecological speciation of an incipient species flock.

PubMed

Burress, E D; Alda, F; Duarte, A; Loureiro, M; Armbruster, J W; Chakrabarty, P

2018-01-01

The rapid rise of phenotypic and ecological diversity in independent lake-dwelling groups of cichlids is emblematic of the East African Great Lakes. In this study, we show that similar ecologically based diversification has occurred in pike cichlids (Crenicichla) throughout the Uruguay River drainage of South America. We collected genomic data from nearly 500 ultraconserved element (UCEs) loci and >260 000 base pairs across 33 species, to obtain a phylogenetic hypothesis for the major species groups and to evaluate the relationships and genetic structure among five closely related, endemic, co-occurring species (the Uruguay River species flock; URSF). Additionally, we evaluated ecological divergence of the URSF based on body and lower pharyngeal jaw (LPJ) shape and gut contents. Across the genus, we recovered novel relationships among the species groups. We found strong support for the monophyly of the URSF; however, relationships among these species remain problematic, likely because of the rapid and recent evolution of this clade. Clustered co-ancestry analysis recovered most species as well delimited genetic groups. The URSF species exhibit species-specific body and LPJ shapes associated with specialized trophic roles. Collectively, our results suggest that the URSF consists of incipient species that arose via ecological speciation associated with the exploration of novel trophic roles. © 2017 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2017 European Society For Evolutionary Biology.

Supplementation of lactobacilli improves growth, regulates microbiota composition and suppresses skeletal anomalies in juvenile pike-perch (Sander lucioperca) reared in recirculating aquaculture system (RAS): A pilot study.

PubMed

Ljubobratovic, Uros; Kosanovic, Dejana; Vukotic, Goran; Molnar, Zsuzsanna; Stanisavljevic, Nemanja; Ristovic, Tijana; Peter, Geza; Lukic, Jovanka; Jeney, Galina

2017-12-01

This research aimed to test the effects of lactobacilli, applied to cultured pike-perch, either through hydrolyzed OTOHIME fish diet, or through Artemia nauplii, on fish growth, microbiota balance and skeletal development. On the 12th Day Post Hatching (DPH) fish were divided into following treatment groups: two groups received the combination of OTOHIME and nauplii enriched either with Lactobacillus paracasei BGHN14+Lactobacillus rhamnosus BGT10 or with Lactobacillus reuteri BGGO6-55+Lactobacillus salivarius BGHO1, and one group received OTOHIME hydrolyzed by BGHN14+BGT10 and non-enriched nauplii. Control group received non-enriched nauplii and non-hydrolyzed OTOHIME. The treatment lasted 14days and fish were sacrificed on the 26th DPH for the assessment of digestive enzyme activity and microbiota composition. Individual total lengths and individual body weights were recorded at the end of the treatments, on the 26th DPH, and also on the 45th DPH, in parallel with the evaluation of skeletal deformities and fish survival. Our results indicated positive effect of Artemia enriched with BGGO6-55+BGHO1 on fish growth, skeletal development and trypsin to chymotrypsin activity ratio (T/C), as an indicator of protein digestibility. Hydrolysis of OTOHIME was also associated with better skeletal development, higher T/C values and lower levels of Aeromonas and Mycobacterium spp., which are important fish pathogens. Though additional testing in larger cohort studies is needed, these observations are promising in terms of usage of probiotics for improved environmentally friendly production of pike-perch in Recirculating Aquaculture System (RAS). Copyright © 2017 Elsevier Ltd. All rights reserved.

Review of the Bethesda System for Reporting Thyroid Cytopathology: a local study in Bohol Island, Philippines.

PubMed

Salillas, Annette L; Sun, Faye Candice S; Almocera, Emelisa G

2015-01-01

The aim of this study was to evaluate the adaptability and reproducibility of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) in a local setting and to determine the risk of malignancy for each category. A retrospective cross-sectional study of 80 thyroid fine-needle aspiration cytology cases using the BSRTC with corresponding histopathology was done between September 2009 and December 2012. Agreement scores were calculated using kappa statistics. Consensus among two readers was attained for 73 cases (91.25%). No disagreement was noted for the malignant cases. The strength of agreement was very good, with a kappa statistic of 0.90. The risk of malignancy observed histologically was as follows: benign 3%, atypia of undetermined significance (AUS) 50%, suspicious for follicular/Hürthle cell neoplasm 50%, suspicious for malignancy 78%, and malignant 100%. In this study, there is an outstanding reproducibility for the classification scheme. The application of the BSRTC as the standardized reporting is readily adaptable and therefore its application in larger medical centers is highly recommended. Our findings of a higher risk of malignancy seen in AUS (50%) and malignant (100%) categories in those who underwent surgical resection corroborated other published studies. Conveying this risk to clinical colleagues is important and will facilitate optimal patient care. © 2015 S. Karger AG, Basel.

Bethesda Conference #36 and the European Society of Cardiology Consensus Recommendations revisited a comparison of U.S. and European criteria for eligibility and disqualification of competitive athletes with cardiovascular abnormalities.

PubMed

Pelliccia, Antonio; Zipes, Douglas P; Maron, Barry J

2008-12-09

Aspiration to reduce the risks of athletic field deaths prompted the American Heart Association and European Society of Cardiology (ESC) to establish consensus guidelines for eligibility/disqualification decisions in competitive athletes with cardiovascular abnormalities. Since 2005, the Bethesda Conference #36 and the ESC consensus documents have been relied upon by physicians from different parts of the world. The 2 consensus documents emanate from largely different cultural, social, and legal backgrounds existing in the U.S. and Europe and, although several recommendations are similar, in some instances the Bethesda Conference #36 and the ESC consensus documents suggest different approaches to disqualification decisions and implications for clinical practice, raising the possibility that confusion and discrepancies will contaminate the management of competitive athletes with cardiovascular disease. In the present article, the differences between the 2 documents are critically viewed, with special attention to genetic cardiovascular diseases relevant to sudden death in young athletes, through the prism of different cultural backgrounds, societal attitudes, and also perceptions regarding exposure to legal liability in the U.S. and Europe. In conclusion, it seems appropriate at some time to consider assembling updated recommendations for sports eligibility/disqualification that assimilate both the U.S. and European perspectives, with the aspiration of creating a unique and authoritative document applicable to the global sports medicine community.

Petrology and geochemistry of late-stage intrusions of the A-type, mid-Proterozoic Pikes Peak batholith (Central Colorado, USA): Implications for petrogenetic models

USGS Publications Warehouse

Smith, D.R.; Noblett, J.; Wobus, R.A.; Unruh, D.; Douglass, J.; Beane, R.; Davis, C.; Goldman, S.; Kay, G.; Gustavson, B.; Saltoun, B.; Stewart, J.

1999-01-01

The ~1.08 Ga anorogenic, A-type Pikes Peak batholith (Front Range, central Colorado) is dominated by coarse-grained, biotite ?? amphibole syenogranites and minor monzogranites, collectively referred to as Pikes Peak granite (PPG). The batholith is also host to numerous small, late-stage plutons that have been subdivided into two groups (e.g. Wobus, 1976. Studies in Colorado Field Geology, Colorado School of Mines Professional Contributions, Colorado): (1) a sodic series (SiO2= ~44-78 wt%; K/Na=0.32-1.36) composed of gabbro, diabase, syenite/quartz syenite and fayalite and sodic amphibole granite; and (2) a potassic series (SiO2= ~ 70-77 wt%; K/Na=0.95-2.05), composed of biotite granite and minor quartz monzonite. Differences in major and trace element and Nd isotopic characteristics for the two series indicate different petrogenetic histories. Potassic granites of the late-stage intrusions appear to represent crustal anatectic melts derived from tonalite sources, based on comparison of their major element compositions with experimental melt products. In addition, Nd isotopic characteristics of the potassic granites [??(Nd)(1.08 Ga) = -0.2 to -2.7] overlap with those for tonalites/granodiorites [ca 1.7 Ga Boulder Creek intrusions; ??(Nd)(1.08 Ga) = -2.4 to -3.6] exposed in the region. Some of the partial melts evolved by fractionation dominated by feldspar. The late-stage potassic granites share geochemical characteristics with most of the PPG, which is also interpreted to have an anatectic origin involving tonalitic crust. The origin of monzogranites associated with the PPG remains unclear, but mixing between granitic and mafic or intermediate magmas is a possibility. Syenites and granites of the sodic series cannot be explained as crustal melts, but are interpreted as fractionation products of mantle-derived mafic magmas with minor crustal input. High temperature and low oxygen fugacity estimates (e.g. Frost et al., 1988. American Mineralogist 73, 727-740) support

Occurrence and attempted mitigation of carbon dioxide in a home constructed on reclaimed coal-mine spoil, Pike County, Indiana

USGS Publications Warehouse

Robinson, Bret A.

2010-01-01

In recent years carbon dioxide intrusion has become recognized as a potentially serious health threat where homes are constructed on or near reclaimed surface coal mines. When carbon dioxide invades the living space of a home, it can collect near the floor, displace the oxygen there, and produce an oxygen-deficient environment. In this investigation, several lines of inquiry were pursued to determine the environmental factors that most influence carbon dioxide intrusion at a Pike County, Ind., home where this phenomenon is known to occur. It was found that carbon dioxide intrusion events at the home are most closely tied to rapid drops in barometric pressure and rainfall. Other researchers have shown that windy conditions and periods of cold weather also can contribute to soil-gas intrusion to structures. From this, a conceptual model was developed to illustrate the influence of these four meteorological conditions. Additionally, three mitigation methods-block-wall depressurization, block-wall and sub-slab depressurization, and block-wall and sub-slab pressurization-were applied successively to the study-site home, and environmental data were collected to evaluate the effectiveness of each mitigation method. In each case, it was found that these methods did not ensure a safe environment when meteorological conditions were favorable for carbon dioxide intrusion.

Estimated probabilities and volumes of postwildfire debris flows—A prewildfire evaluation for the Pikes Peak area, El Paso and Teller Counties, Colorado

USGS Publications Warehouse

Elliott, John G.; Ruddy, Barbara C.; Verdin, Kristine L.; Schaffrath, Keelin R.

2012-01-01

Debris flows are fast-moving, high-density slurries of water, sediment, and debris that can have enormous destructive power. Although debris flows, triggered by intense rainfall or rapid snowmelt on steep hillsides covered with erodible material, are a common geomorphic process in some unburned areas, a wildfire can transform conditions in a watershed with no recent history of debris flows into conditions that pose a substantial hazard to residents, communities, infrastructure, aquatic habitats, and water supply. The location, extent, and severity of wildfire and the subsequent rainfall intensity and duration cannot be known in advance; however, hypothetical scenarios based on empirical debris-flow models are useful planning tools for conceptualizing potential postwildfire debris flows. A prewildfire study to determine the potential for postwildfire debris flows in the Pikes Peak area in El Paso and Teller Counties, Colorado, was initiated in 2010 by the U.S. Geological Survey, in cooperation with the City of Colorado Springs, Colorado Springs Utilities. The study was conducted to provide a relative measure of which subwatersheds might constitute the most serious potential debris-flow hazards in the event of a large-scale wildfire and subsequent rainfall.

Application of the Bethesda System for Reporting Thyroid Cytopathology in the Eastern Province of Saudi Arabia: A Follow-Up Study.

PubMed

Alabdulqader, Noof A; Shareef, Sameera Q; Ali, Jassim A; Yousef, Mohammad M; Al-Abbadi, Mousa A

2015-01-01

This is a follow-up study to our previous analysis of thyroid aspirates utilizing the Bethesda System for Reporting Thyroid Cytology (BSRTC). The same study design was utilized for 2 years comparing 2 periods. A total of 251 thyroid aspirates from 218 patients were reviewed and deemed comparable to the previous cohort. The variance and consequently the number of interpretations dropped from 26 to 11 with a statistically significant 58% reduction and more consistency. Our unsatisfactory rate dropped from 22 to 10% (reduction of 55%). The risk of malignancy in this follow-up study showed a similar trend: an increase in risk with each step up in the BSRTC categories starting from the 'nondiagnostic' and up to 'malignant'. Few of our benign cases ended up with resection. We noticed sensitivity to the word 'follicular' in this benign category; therefore we propose a modification of the current BSRTC system by omitting the word 'follicular' from the benign category. We strongly believe that this modification harbors no serious damage to the intentions of BSRTC. This follow-up study has shown that the previous awareness campaign about the implementation has worked and can be considered a valid performance improvement program. © 2015 S. Karger AG, Basel.

Water quality, hydrology, and the effects of changes in phosphorus loading to Pike Lake, Washington County, Wisconsin, with special emphasis on inlet-to-outlet short-circuiting

USGS Publications Warehouse

Rose, William J.; Robertson, Dale M.; Mergener, Elizabeth A.

2004-01-01

Simulations using water-quality models within the Wisconsin Lake Model Suite (WiLMS) indicated Pike Lake's response to 13 different phosphorus-loading scenarios. These scenarios included a base 'normal' year (2000) for which lake water quality and loading were known, six different percentage increases or decreases in phosphorus loading from controllable sources, and six different loading scenarios corresponding to specific management actions. Model simulations indicate that a 50-percent reduction in controllable loading sources would be needed to achieve a mesotrophic classification with respect to phosphorus, chlorophyll a, and Secchi depth (an index of water clarity). Model simulations indicated that short-circuiting of phosphorus from the inlet to the outlet was the main reason the water quality of the lake is good relative to the amount of loading from the Rubicon River and that changes in the percentage of inlet-to-outlet short-circuiting have a significant influence on the water quality of the lake.

Diagnostic Thyroidectomy May Be Preferable in Patients With Suspicious Ultrasonography Features After Cytopathology Diagnosis of AUS/FLUS in the Bethesda System

PubMed Central

Lee, Yong Sang; Kim, Hyeung Kyoo; Chang, Hojin; Kim, Seok Mo; Kim, Bup-Woo; Chang, Hang-Seok; Park, Cheong Soo

2015-01-01

Abstract Atypia/follicular lesion of undetermined significance (AUS/FLUS) is a new category in the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) for which repeat fine-needle aspiration cytology (FNAC) is recommended. The aim of this study was to identify specific ultrasonography and clinical predictors of malignancy in a subset of thyroid nodules associated with cytology diagnoses of AUS/FLUS. Between January 2011 and December 2102, 5440 patients underwent thyroid surgery at our institution. Of these, 213 patients were diagnosed AUS/FLUS at the preoperative cytopathology diagnosis. The frequency of FNAC and ultrasonography images was compared between patients with cancerous and benign tumors based on their final pathology. Of the 213 patients, 158 (74.2%) were diagnosed with thyroid carcinoma in their final pathology reports. In univariate and multivariate analyses, the frequency of FNAC was not significantly correlated with the cancer diagnosis. Hypoechogenicity (odds ratio 2.521, P = 0.007) and microcalcification (odds ratio 3.247, P = 0.005) were statistically correlated with cancer risk. Although AUS/FLUS in cytopathology is recommended for repeating FNAC in BSRTC, we proposed that thyroid nodules with ultrasonography findings that suggest the possibility of cancer should undergo thyroidectomy with diagnostic intent. PMID:26705204

Cytological Diagnosis of Follicular Variant of Papillary Thyroid Carcinoma before and after the Bethesda System for Reporting Thyroid Cytopathology.

PubMed

Fazeli, Roghayeh; VandenBussche, Christopher J; Bishop, Justin A; Ali, Syed Z

2016-01-01

The follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common subtype of papillary carcinoma after the classical variant. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has been introduced to standardize the practice of thyroid fine needle aspiration (FNA) reporting. We evaluated the impact of TBSRTC on the FNA interpretation of histologically proven FVPTCs. Cytology reports of 455 histologically proven FVPTCs were reviewed. The rate of each TBSRTC category was compared between pre- and post-TBSRTC eras. The distribution of FNA diagnoses for pre-TBSRTC cases included suspicious for follicular neoplasm (SFN; n = 51, 28.7%), papillary thyroid carcinoma (PTC; n = 47, 26.4%), suspicious for malignancy (SFM; n = 32, 18%), atypia of undetermined significance (AUS; n = 23, 13%), benign (n = 18, 10.1%), and nondiagnostic (ND; n = 7, 4%). Post-TBSRTC diagnoses were: AUS (n = 68, 24.6%), PTC (n = 64, 23.1%), SFM (n = 50, 18%), SFN and benign (n = 42, 15.2%) and ND (n = 11, 4%). SFN rate decreased significantly from 28.7 to 15.2% (p = 0.001) and AUS increased from 12.9 to 24.5% (p = 0.003). Following implementation of TBSRTC, the frequency of AUS diagnoses on FNA prior to surgical resection increased. Given that the rate of FVPTC diagnoses on thyroidectomy increased over the same period, this suggests that the use of AUS has resulted in greater surgical resection of FVPTC. © 2016 S. Karger AG, Basel.

Polybrominated diphenyl ethers (PBDEs) and their methoxylated derivatives in pike from Swedish waters with emphasis on temporal trends, 1967-2000.

PubMed

Kierkegaard, A; Bignert, A; Sellström, U; Olsson, M; Asplund, L; Jansson, B; De Wit, C A

2004-07-01

Temporal trends of five tetra- to hexabromodiphenyl ethers [BDE47, BDE99, BDE100, BDE153 and BDE154) and two methoxy-tetraBDEs [6-methoxy-2,2',4,4'- tetraBDE (6-MeO-BDE47) and 2'-methoxy-2,3',4,5'- tetraBDE (2'-MeO-BDE68)] in pike from Lake Bolmen for the years 1967-2000, are presented. All BDE congeners show increasing trends up to the mid-1980s (Sigma5PBDE from 60 to 1600 pg/g wet weight in 1989, i.e. a more than 25-fold increase), and then decrease or level off. The decreasing trends of PBDEs after the 1980s were considerably slower in the present study than was found in a study of an environmental matrix from the Baltic Proper covering the same time period. This difference suggests local sources near Lake Bolmen. The MeO-BDEs show initially decreasing concentrations, which for 6-MeO-BDE47 continues until the early 1990s. The concentrations of 6-MeO-BDE47 in herring from five locations along the Swedish coast increased from south to north in the Baltic Sea. No correlation between the concentrations of the BDE congeners and the MeO-BDEs was observed, indicating sources other than PBDEs for these compounds. The presence of MeO-BDEs in fish from lakes with different characteristics suggests a natural production not favoured by eutrophication, or dependent on sampling season and geographical location.

Stability Analysis of Finite Difference Approximations to Hyperbolic Systems, and Problems in Applied and Computational Matrix Theory

DTIC Science & Technology

1988-07-08

Marcus and C. Baczynski), Computer Science Press, Rockville, Maryland, 1986. 3. An Introduction to Pascal and Precalculus , Computer Science Press...Science Press, Rockville, Maryland, 1986. 35. An Introduction to Pascal and Precalculus , Computer Science Press, Rockville, Maryland, 1986. 36

77 FR 54919 - National Institute on Drug Abuse; Notice of Closed Meetings

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The Pikes Peak batholith, Colorado front range, and a model for the origin of the gabbro-anorthosite-syenite-potassic granite suite

USGS Publications Warehouse

Barker, F.; Wones, D.R.; Sharp, W.N.; Desborough, G.A.

1975-01-01

This study of the Pikes Peak batholith includes the mineralogy and petrology of quartz syenite at West Creek and of fayalite-bearing and fayalite-free biotite granite near Mount Rosa; major element chemistry of the batholith; comparisons with similar postorogenic, intracratonic, sodic to potassic intrusives; and genesis of the batholith. The batholith is elongate in plan, 50 by 100 km, composite, and generally subalkalic. It was emplaced at shallow depth 1,040 m. y. ago, sharply transects its walls and may have breached its roof. Biotite granite and biotite-hornblende granite are predominant; quartz syenite, fayalite granite and riebeckite granite are present in minor amounts. Fayalite-bearing and fayalite-free quartz syenite, fayalite-biotite granite and riebeckite granite show a well-defined sodic differentiation trend; the less sodic fayalite-free granites exhibit a broader compositional range and no sharp trends. Crystallization was largely at PH2O < Ptotal; PH2O approached Ptotal only at late stages. Aplite residual to fayalite-free biotite granite in the north formed at about 1,500 bars, or 5 km depth. Feldspar assemblages indicate late stages of crystallization at about 720??C. In the south ilmenite and manganian fayalite indicate fO2 of 10-17 or 10-18 bars. Biotite and fayalite compositions and the 'granite minimum' imply completion of crystallization at about 700??C and 1,500 bars. Nearby fayalite-free biotite granite crystallized at higher water fugacity. All types of syenite and granite contain 5-6% K2O through a range of SiO2 of 63-76%. Average Na2O percentages in quartz syenite are 6.2, fayalite granite 4.2, and fayalite-free granite 3.3 MgO contents are low, 0.03-0.4%; FeO averages 1.9-2.5%. FeO/Fe2O3 ratios are high. Fluorine ranges from 0.3 to 0.6%. The Pikes Peak intrusives are similar in mode of emplacement, composition, and probably genesis to rapakivi intrusives of Finland, the Younger Granites of Nigeria, Cape Ann Granite and Beverly Syenite

U.S. Northern Command > Newsroom > Speeches

Science.gov Websites

. Boccardi speaks at the Pikes Peak Veterans Council Memorial Day ceremony May 29, 2017. May 31, 2017 Pikes Peak Veterans Council, Memorial Day Speech PETERSON AFB, Colo. - Special Thanks to the Pikes Peak

Papanicolaou smear findings in solid-organ transplant recipients compared with normal subjects according to the Bethesda 2001 system.

PubMed

Ok Atılgan, Alev; Tepeoğlu, Merih; Haberal, A Nihan; Durukan, Elif; Kuşcu, Esra; Haberal, Mehmet

2015-04-01

Solid-organ transplant recipients are at increased risk of developing cancer including cervical cancer compared with woman in the general population, mostly due to long-term immunosuppressive therapy. The Papanicolaou smear remains the primary method of screening cervical pathology including preinvasive and invasive lesions. The objective of this study was to evaluate Pap smear findings in solid-organ transplant recipients, determine the prevalence of abnormal smears, and compare these patients with the general population. We retrospectively examined 111 women patients who received liver or kidney transplant between January 1990 to December 2012 at Başkent University Ankara Hospital. Pap smear findings were compared with normal control patients matched for same age and technical procedure of cervical cytology. To selection of control patients, propensity score matching program was performed. All Pap smears were re-examined according to Bethesda 2001 criteria. In 111 transplant patients, 2 patients (1.8%) had atypical squamous cells of undetermined significance, 8 patients (7.2%) had low-grade squamous intraepithelial lesion, 15 patients (13.5%) had Candida infection, 2 patients (1.8%) had Trichomonas vaginalis, 1 patient (0.9%) had herpes simplex infection, 13 patients (11.7%) had bacterial vaginosis, 15 patients (13.5%) had reactive changes due to inflammation, and 18 patients (16.2%) had atrophy. When we compared our results with the control group, there were statistically significant differences (P ≤ .05) between the 2 groups in epithelial cell abnormalities (low-grade squamous intraepithelial lesion), Candida infection, bacterial vaginosis, and atrophy. Pap smear screening potentially may help recognize cervical preinvasive and invasive lesions. The risk of developing cervical intraepithelial neoplasia is greater in transplant recipients because of immunosuppressive therapy. The incidence of low-grade squamous intraepithelial lesion was significantly greater

Thyroid fine-needle aspiration reporting rates and outcomes before and after Bethesda implementation within a combined academic and community hospital system.

PubMed

Harvey, Aaron M; Mody, Dina R; Amrikachi, Mojgan

2013-11-01

The current study compares data from our hospital system before and after the 2008 implementation of the Bethesda System for Reporting Thyroid Cytology (BSRTC). To show the effects the BSRTC has had on the reporting rates and outcomes for thyroid lesions. A search for thyroid fine-needle aspiration biopsies (FNABs) was performed for 2002-2005 (before BSRTC) and 2009-2011 (after BSRTC). Diagnostic outcomes were reviewed for cases with available follow-up. For 2002-2005, cytology reports for 3302 thyroid FNABs were reviewed, and 309 (9.4%) were classified as suspicious. For 2009-2011, cytology reports for 3432 thyroid FNABs were reviewed; 72 (2.1%) were classified as "atypia of undetermined significance or follicular lesion of undetermined significance" (AUS/FLUS), and 142 (4.1%) were classified as suspicious. Follow-up material was available for 31 AUS/FLUS cases (43.0%), and 6 of these cases (19%) were malignant. Follow-up material was available for 60 cases (42.3%) classified as suspicious, and 23 of these cases (38%) were malignant. The AUS/FLUS rate of 2.1% at our institution is at the lower range of the <7% recommended by the BSRTC, and our rate of 19% for risk of malignancy for AUS/FLUS is slightly above the BSRTC recommendation of 5% to 15%. Implementation of the BSRTC did not significantly affect our institution's reporting rates, most likely because an essentially similar classification system was employed before implementation of the BSRTC.

Slope-area thresholds of road-induced gully erosion and consequent hillslope-channel interactions

Treesearch

Harry Alexander Katz; J. Michael Daniels; Sandra Ryan-Burkett

2014-01-01

Pikes Peak Highway is a partially paved road between Cascade, Colorado and the summit of Pikes Peak. Significant gully erosion is occurring on the hillslopes due to the concentration of surface runoff, the rearrangement of drainage pathways along the road surface and adjacent drainage ditches, and the high erodibility of weathered Pikes Peak granite that underlies the...

76 FR 73644 - Meeting of the Advisory Committee on Minority Health

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Gerstmann-Straussler-Scheinker Disease

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Water-quality data for the Ohio River from New Cumberland Dam to Pike Island Dam, West Virginia and Ohio, June-November 1992

USGS Publications Warehouse

Miller, Kimberly F.; Faulkenburg, C.W.; Chambers, D.B.; Waldron, M.C.

1995-01-01

This report contains water-quality data for the Ohio River, collected during the summer and fall of 1992, from river mile 51.1 (3.3 miles upstream from New Cumberland Dam) to river mile 84.0 (0.2 miles upstream from Pike Island Dam). The data were collected to assess the effects of hydropower development on water quality. Water quality was determined by a combination of repeated synoptic field measurements and laboratory analyses. Synoptic measurements were made along a longitudinal transect with 18 mid-channel sampling sites; cross-sectional transects of water quality were measured at 5 of these sites. Water-quality measurements also were made at two sites located on the back-channel (Ohio) side of Browns Island. Water temperature, dissolved oxygen concentration, pH, and specific conductance were measured at each longitudinal-transect and back-channel sampling site. Longitudinal-transect and back-channel stations were sampled at three depths (about 3.3 feet below the surface of the water, middle of the water column, and near the bottom of the river). Cross-sectional transects consisted of three or four detailed vertical pro- files of the same characteristics. Water samples were collected from three depths at the mid-channel vertical profile in each cross-sectional transect and were analyzed for concentrations of phyto- plankton photosynthetic pigments chlorophyll a and chlorophyll b. Estimates of the depth of light penetration (Secchi disk transparency) were made at pigment-sampling locations whenever light and river-surface conditions were appropriate. Synoptic sampling usually was completed in 12 hours or less and was repeated seven times between June 25 and November 6, 1992.

Winter movements of four fish species near a thermal plume in northern Minnesota

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ross, M.J.; Winter, J.D.

1981-01-01

During winter 1975, 17 yellow perch (Perca flavescens), 6 northern pike (Esox lucius), 3 walleyes (Stizostedion vitreum), and 2 largemouth bass (Micropterus salmoides) were equipped with radio frequency transmitters to compare their winter movements near the thermal plume of a power plant. The mean home range sizes, in hectares, were northern pike 19.0; yellow perch 13.4; largemouth bass 3.7; walleye 2.2. Northern pike and yellow perch had mean home range sizes larger than the discharge area. Mean water depths at fish locations were as follows: largemouth bass 0.8 m; northern pike 1.2 m; yellow perch 1.6 m; walleye 3.5 m.more » Largemouth bass preferred the warmest locations near the discharge point. Yellow perch were most often located in the peripheral areas of the discharge bay while walleyes were most often located in the deeper center area. Northern pike moved over the entire discharge area. All species except largemouth bass moved freely between discharge-affected and unaltered waters. The average numbers of movements per individual per week between heated and unheated areas were the following: northern pike 0.8; yellow perch 1.2; walleye 1.1; largemouth bass, 0.« less

Heterogeneity in Positive Predictive Value of RAS Mutations in Cytologically Indeterminate Thyroid Nodules.

PubMed

Nabhan, Fadi; Porter, Kyle; Lupo, Mark A; Randolph, Gregory W; Patel, Kepal N; Kloos, Richard T

2018-06-01

RAS mutations are common in the available mutational analysis of cytologically indeterminate (Cyto-I) thyroid nodules. However, their reported positive predictive value (PPV) for cancer is widely variable. The reason for this variability is unknown, and it causes clinical management uncertainty. A systematic review was performed, evaluating the PPV for cancer in RAS mutation positive Cyto-I nodules, and variables that might affect residual heterogeneity across the different studies were considered. PubMed was searched through February 22, 2017, including studies that evaluated at least one type of RAS mutation in Cyto-I nodules, including any (or all) of the Bethesda III/IV/V categories or their equivalents and where the histological diagnosis was available. The PPV residual heterogeneity was investigated after accounting for Bethesda classification, blindedness of the histopathologist to the RAS mutational status, Bethesda category-specific cancer prevalence for each study, and which RAS genes and codons were tested. This was studied using five meta-regression models fit to different sets of Bethesda classification categories: Bethesda III, IV, or V (III/IV/V); Bethesda III or IV (III/IV); Bethesda III only; Bethesda IV only; and Bethesda V only. Of 1831 studies, 23 were eligible for data inclusion. Wide ranges of PPV were found at 0-100%, 28-100%, and 0-100% in Bethesda III, IV, and V, respectively. Residual heterogeneity remained moderately high for PPV after accounting for the above moderators for Bethesda III/IV/V (21 studies; I 2  = 59.5%) and Bethesda III/IV (19 studies; I 2  = 66.0%), with significant Cochran's Q-test for residual heterogeneity (p < 0.001). Among individual Bethesda categories, residual heterogeneity was: Bethesda III (eight studies; I 2  = 89.0%), IV (12 studies; I 2  = 53.5%), and V (10 studies; I 2  = 34.4%), with significant Cochran's Q-test for Bethesda III (p < 0.001) and IV (p = 0.04). The PPV of RAS

78 FR 20927 - Tobacco Products Scientific Advisory Committee; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-08

...., Rockville, MD 20850, 1-877-287- 1373. Contact Person: Caryn Cohen, Center for Tobacco Products, Food and Drug Administration, 9200 Corporate Blvd., Rockville, MD 20850, 1-877- 287-1373 (choose option 5..., an order from [[Page 20928

77 FR 12858 - National Institute on Drug Abuse; Notice of Closed Meetings

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2012-03-02

... grant applications. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard...: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852..., Neuroscience Center, 6001 Executive Boulevard Rockville, MD 20852 (Telephone Conference Call). Contact Person...

76 FR 7575 - National Institute on Drug Abuse; Notice of Closed Meetings

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2011-02-10

... evaluate grant applications. Place: National Institutes of Health, Neuroscience Center, 6001 Executive... Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Virtual Meeting... Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Virtual Meeting). Contact...

76 FR 572 - National Institute of Mental Health; Notice of Closed Meetings

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2011-01-05

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76 FR 78671 - National Institute on Drug Abuse; Notice of Closed Meetings

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2011-12-19

..., Neuroscience Center, 6001 Executive Boulevard Rockville, MD 20852 (Telephone Conference Call). Contact Person... proposals. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard Rockville, MD... proposals. Place: National Institutes of Health, Neuroscience Center, 6001 Executive [[Page 78672...

78 FR 57167 - National Institute on Deafness and Other Communication Disorders; Notice of Closed Meetings

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2013-09-17

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77 FR 35411 - National Institute of Mental Health; Notice of Closed Meetings

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2012-06-13

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77 FR 72362 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

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2012-12-05

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78 FR 2414 - National Institute of Mental Health; Notice of Closed Meetings

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2013-01-11

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Directory of Organizational Technical Report Acronym Codes (DOTRAC)

DTIC Science & Technology

1994-07-01

TM - Technical memo report........................................................... TMR- Technical news bulletin...BETHESDA 418182 MD DTRC- TM -12 DAVID TAYLOR RESEARCH CENTER BETHESDA 418631 MD SHIP SYSTEMS INTEGRATION DEPT DTRC- TM -14 DAVID TAYLOR RESEARCH CENTER...BETHESDA 419277 MD SHIP ELECTROMAGNETIC SIGNATURES DEPT DTRC- TM -15 DAVID TAYLOR RESEARCH CENTER BETHESDA 418173 MD SHIP HYDROMECHANICS DEPT DTRC- TM -16 DAVID

21 CFR 500.1410 - N-methyl-2-pyrrolidone.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Administration, 7519 Standish Pl., Rockville, MD 20855, 240-276-9120; or go to http://www.fda.gov/AboutFDA..., Rockville, MD 20852, (301) 827-6860, between 9 a.m. and 4 p.m., Monday through Friday or at the National...

Body downsizing caused by non-consumptive social stress severely depresses population growth rate

PubMed Central

Edeline, Eric; Haugen, Thrond O.; Weltzien, Finn-Arne; Claessen, David; Winfield, Ian J.; Stenseth, Nils Chr.; Vøllestad, L. Asbjørn

2010-01-01

Chronic social stress diverts energy away from growth, reproduction and immunity, and is thus a potential driver of population dynamics. However, the effects of social stress on demographic density dependence remain largely overlooked in ecological theory. Here we combine behavioural experiments, physiology and population modelling to show in a top predator (pike Esox lucius) that social stress alone may be a primary driver of demographic density dependence. Doubling pike density in experimental ponds under controlled prey availability did not significantly change prey intake by pike (i.e. did not significantly change interference or exploitative competition), but induced a neuroendocrine stress response reflecting a size-dependent dominance hierarchy, depressed pike energetic status and lowered pike body growth rate by 23 per cent. Assuming fixed size-dependent survival and fecundity functions parameterized for the Windermere (UK) pike population, stress-induced smaller body size shifts age-specific survival rates and lowers age-specific fecundity, which in Leslie matrices projects into reduced population rate of increase (λ) by 37–56%. Our models also predict that social stress flattens elasticity profiles of λ to age-specific survival and fecundity, thus making population persistence more dependent on old individuals. Our results suggest that accounting for non-consumptive social stress from competitors and predators is necessary to accurately understand, predict and manage food-web dynamics. PMID:19923130

Diffusion MRI and the Detection of Alterations Following Traumatic Brain Injury

DTIC Science & Technology

2017-06-13

Bioengineering, National Institutes of Health , Bethesda, Maryland 2Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National...Institute of Child Health and Human Development, National Institutes of Health , Bethesda, Maryland 3Henry M. Jackson Foundation for the Advancement of...Military Medicine, Inc, Bethesda, Maryland 4Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda

75 FR 37450 - Draft Guidance: The Judicious Use of Medically Important Antimicrobial Drugs in Food-Producing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-29

... (HFV-12), Center for Veterinary Medicine, Food and Drug Administration, 7519 Standish Pl., Rockville..., Rockville, MD 20852. FOR FURTHER INFORMATION CONTACT: William T. Flynn, Center for Veterinary Medicine (HFV... Food-Producing Animals.'' Antimicrobial drugs have been widely used in human and veterinary medicine...

75 FR 3740 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-22

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852. (Telephone Conference Call.) Contact Person... Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6154, MSC 9609, Rockville, MD 20892... Activities, National Institute of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6148...

21 CFR 600.2 - Mailing addresses.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (HFM-99), Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville... biological products regulated by the Center for Drug Evaluation and Research (CDER). Unless otherwise stated... Research, Food and Drug Administration, 12229 Wilkins Ave., Rockville, MD 20852. Examples of such...

21 CFR 600.2 - Mailing addresses.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (HFM-99), Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville... biological products regulated by the Center for Drug Evaluation and Research (CDER). Unless otherwise stated... Research, Food and Drug Administration, 12229 Wilkins Ave., Rockville, MD 20852. Examples of such...

11. VIEW NORTH, WOODLYNNE AVENUE ISLAND FROM 130 SOUTH ISLAND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. VIEW NORTH, WOODLYNNE AVENUE ISLAND FROM 130 SOUTH ISLAND - White Horse Pike Rond Point, Intersection of Crescent Boulevard (U.S. Route 130), White Horse Pike (U.S. Route 30), & Clay Avenue, Collingswood, Camden County, NJ

78 FR 47715 - National Human Genome Research Institute; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-06

... space available. Individuals who plan to attend and need special assistance, such as sign language...: National Institutes of Health, Terrace Level Conference Room, 5635 Fishers Lane, Rockville, MD 20892. Open... Institutes of Health, Terrace Level Conference Room, 5635 Fishers Lane, Rockville, MD 20892. Closed...

13. VIEW SOUTH, ROUTE 130 SOUTH FROM ROUTE 130 SOUTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. VIEW SOUTH, ROUTE 130 SOUTH FROM ROUTE 130 SOUTH ISLAND - White Horse Pike Rond Point, Intersection of Crescent Boulevard (U.S. Route 130), White Horse Pike (U.S. Route 30), & Clay Avenue, Collingswood, Camden County, NJ

12. VIEW EAST, ROUTE 30 EAST FROM ROUTE 130 SOUTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. VIEW EAST, ROUTE 30 EAST FROM ROUTE 130 SOUTH ISLAND - White Horse Pike Rond Point, Intersection of Crescent Boulevard (U.S. Route 130), White Horse Pike (U.S. Route 30), & Clay Avenue, Collingswood, Camden County, NJ

Mineralogical and geochemical evolution of micas from miarolitic pegmatites of the anorogenic pikes peak batholith, Colorado

USGS Publications Warehouse

Foord, E.E.; Cerny, P.; Jackson, L.L.; Sherman, David M.; Eby, R.K.

1995-01-01

A suite of 29 micas from miarolitic pegmatites associated with granitic units of the anorogenic Pikes Peak batholith (1.08-1.02 Ga), Colorado range in composition, and follow in paragenetic sequence, from 1M siderophyllite (N = 1), and 3T or 2M1 lithian biotite (N = 5) to 1M zinnwaldite (N = 20) and 1M ferroan lepidolite (N = 1). Locally, 1M (?) phlogopite (N = 1) and ferroan 2M1 muscovite (N = 1) are also present. Pervasive, late-stage hydrothermal alteration along with possible supergene weathering of many of these micas produced vermiculite. Additionally, some vugs and cavities were filled with chlorite and/or smectite. Early crystallized micas form tapered columnar crystals in graphic pegmatite, growing toward, and adjacent to the miarolitic cavity zone which contains the later crystallized micas. Principal associated minerals are quartz, microcline perthite (mostly amazonite), and albite, with local topaz or fluorite, and rarely tourmaline (schorl-elbaite). Progressively younger micas of the main crystallization sequence display increasing Si, Li, F, and Al/Ga, and decreasing total Fe, Mg, and octahedral occupancy. The zinc content of all micas is considerably elevated, whereas Mn, Rb, Cs, and Sc are moderate and T1 is very low. Early siderophyllite and lithian biotite show a narrow range of FeO/Fe2O3 (5.6-8.0), whereas later zinnwaldite is much more variable (2.4-40.3). Annite of the host granite and early graphic pegmatite is compositionally homogeneous, but most mica crystals from cavities show remarkable compositional and abrupt, sharp and distinct color zoning. Most cavity-grown zinnwaldite crystals show a decrease, from core to rim, in total Fe and Mg, whereas Si, Li and F increase and Mn, Rb, Cs and Na are essentially constant. A few to more than 100 color zones have been identified in some mica crystals. The zones are well correlated with the Ti content (<0.2 wt. % TiO2 colorless, 0.4-0.6 wt.% TiO2 red-brown). The total Fe content may or may not

78 FR 28865 - Request for Comment on the Federal Guidelines for Opioid Treatment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-16

..., Room 7-1044, Rockville, MD 20857. Please allow sufficient time for mailed comments to be received... Federal Register Representative, Division of Pharmacologic Therapies, 1 Choke Cherry Road, Room 7-1044... Representative, Division of Pharmacologic Therapies, 1 Choke Cherry Road, Room 7-1044, Rockville, MD 20850. To...

78 FR 13689 - National Institute of General Medical Sciences; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... Person: Brian R. Pike, Ph.D., Scientific Review Officer, Office of Scientific Review, National Institute... R. Pike, Ph.D., Scientific Review Officer, National Institute of General Medical Sciences, National..., Cell Biology and Biophysics Research; 93.859, Pharmacology, Physiology, and Biological Chemistry...

75 FR 70304 - Advisory Committee on Reactor Safeguards

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-17

..., Rockville, Maryland. Thursday, December 2, 2010, Conference Room T2-B1, Two White Flint North, Rockville... opening remarks regarding the conduct of the meeting. 8:35 a.m.-10 a.m.: Final Safety Evaluation Report... Kewaunee, Inc., regarding the final safety evaluation report associated with the License Renewal...

21 CFR 109.30 - Tolerances for polychlorinated biphenyls (PCB's).

Code of Federal Regulations, 2010 CFR

2010-04-01

... incorporated by reference. Copies are available from the Division of Dockets Management (HFA-305), Food and... Management (HFA-305), Food and Drug Administration, 5630 Fishers Lane, rm. 1061, Rockville, MD 20852. (d) Any... Division of Dockets Management, Food and Drug Administration, 5630 Fishers Lane, rm. 1061, Rockville, MD...

Effects of anesthesia and surgery on serial blood gas values and lactate concentrations in yellow perch (Perca flavescens), walleye pike (Sander vitreus), and koi (Cyprinus carpio).

PubMed

Hanley, Christopher S; Clyde, Victoria L; Wallace, Roberta S; Paul-Murphy, Joanne; Patterson, Tamatha A; Keuler, Nicholas S; Sladky, Kurt K

2010-05-15

OBJECTIVE-To evaluate serial blood gas values and lactate concentrations in 3 fish species undergoing surgery and to compare blood lactate concentrations between fish that survived and those that died during the short-term postoperative period. DESIGN-Prospective cohort study. Animals-10 yellow perch, 5 walleye pike, and 8 koi. PROCEDURES-Blood samples were collected from each fish at 3 time points: before anesthesia, during anesthesia, and immediately after surgery. Blood gas values and blood lactate concentrations were measured. Fish were monitored for 2 weeks postoperatively. RESULTS-All walleye and koi survived, but 2 perch died. Blood pH significantly decreased in perch from before to during anesthesia, but increased back to preanesthesia baseline values after surgery. Blood Pco(2) decreased significantly in perch from before anesthesia to immediately after surgery, and also from during anesthesia to immediately after surgery, whereas blood Pco(2) decreased significantly in koi from before to during anesthesia. Blood Po(2) increased significantly in both perch and koi from before to during anesthesia, and also in koi from before anesthesia to immediately after surgery. For all 3 species, blood lactate concentrations increased significantly from before anesthesia to immediately after surgery. Blood lactate concentration (mean +/- SD) immediately after surgery for the 8 surviving perch was 6.06 +/- 1.47 mmol/L, which was significantly lower than blood lactate concentrations in the 2 nonsurviving perch (10.58 and 10.72 mmol/L). CONCLUSIONS AND CLINICAL RELEVANCE-High blood lactate concentrations following surgery in fish may be predictive of a poor short-term postoperative survival rate.

Summary of breakout session f: facility and equipment decontamination strategies.

PubMed

Norwood, Laurie P; Suvarna, Kalavati

2011-01-01

CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1-3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA).

PDA Cell Substrate Task Force: Emerging Technologies for Virus Detection Technical Document--A Progress Report.

PubMed

King, Kathryn; Wiebe, Michael

2011-01-01

CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1-3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA).

76 FR 60849 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-30

... of Health, Two Democracy Plaza, 6707 Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference..., National Institutes of Health, Room 753, 6707 Democracy Boulevard, Bethesda, MD 20892-2542, (301) 594-8898..., Two Democracy Plaza, 6707 Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference Call...

78 FR 12768 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-25

... Institutes of Health, Two Democracy Plaza, 6707 Democracy Boulevard, Bethesda, MD 20892, (Telephone..., DEA, NIDDK, National Institutes of Health, Room 754, 6707 Democracy Boulevard, Bethesda, MD 20892-5452... Health, Two Democracy Plaza, 6707 Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference Call...

Higher-order organisation of extremely amplified, potentially functional and massively methylated 5S rDNA in European pikes (Esox sp.).

PubMed

Symonová, Radka; Ocalewicz, Konrad; Kirtiklis, Lech; Delmastro, Giovanni Battista; Pelikánová, Šárka; Garcia, Sonia; Kovařík, Aleš

2017-05-18

Pikes represent an important genus (Esox) harbouring a pre-duplication karyotype (2n = 2x = 50) of economically important salmonid pseudopolyploids. Here, we have characterized the 5S ribosomal RNA genes (rDNA) in Esox lucius and its closely related E. cisalpinus using cytogenetic, molecular and genomic approaches. Intragenomic homogeneity and copy number estimation was carried out using Illumina reads. The higher-order structure of rDNA arrays was investigated by the analysis of long PacBio reads. Position of loci on chromosomes was determined by FISH. DNA methylation was analysed by methylation-sensitive restriction enzymes. The 5S rDNA loci occupy exclusively (peri)centromeric regions on 30-38 acrocentric chromosomes in both E. lucius and E. cisalpinus. The large number of loci is accompanied by extreme amplification of genes (>20,000 copies), which is to the best of our knowledge one of the highest copy number of rRNA genes in animals ever reported. Conserved secondary structures of predicted 5S rRNAs indicate that most of the amplified genes are potentially functional. Only few SNPs were found in genic regions indicating their high homogeneity while intergenic spacers were more heterogeneous and several families were identified. Analysis of 10-30 kb-long molecules sequenced by the PacBio technology (containing about 40% of total 5S rDNA) revealed that the vast majority (96%) of genes are organised in large several kilobase-long blocks. Dispersed genes or short tandems were less common (4%). The adjacent 5S blocks were directly linked, separated by intervening DNA and even inverted. The 5S units differing in the intergenic spacers formed both homogeneous and heterogeneous (mixed) blocks indicating variable degree of homogenisation between the loci. Both E. lucius and E. cisalpinus 5S rDNA was heavily methylated at CG dinucleotides. Extreme amplification of 5S rRNA genes in the Esox genome occurred in the absence of significant pseudogenisation

75 FR 75482 - Draft Guidance for Industry on Residual Solvents in Animal Drug Products; Questions and Answers...

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2010-12-03

... Administration, 7519 Standish Pl., Rockville, MD 20855. Send one self-addressed adhesive label to assist that..., Center for Veterinary Medicine (HFV-145), Food and Drug Administration, 7500 Standish Pl., Rockville, MD... seen in the Division of Dockets Management between 9 a.m. and 4 p.m., Monday through Friday. V...

78 FR 11896 - Center for Scientific Review; Notice of Closed Meetings

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2013-02-20

... Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: Nancy Sheard, SCD, Scientific Review...: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person..., Bethesda, MD 20892, (Virtual Meeting). Contact Person: Heidi B Friedman, Ph.D., Scientific Review Officer...

75 FR 76019 - National Institute of Biomedical Imaging and Bioengineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-07

... strategic plan. Place: Bethesda Marriott Suites, 6711 Democracy Boulevard, Independence Room (2nd Level... proposals. Place: Bethesda Marriott Suites, 6711 Democracy Boulevard, Independence Room (2nd Level), Bethesda, MD 20817. Contact Person: Anthony Demsey, PhD, Director, National Institute of Biomedical Imaging...

78 FR 66027 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

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2013-11-04

...: National Institutes of Health, Two Democracy Plaza, 6707 Democracy Boulevard, Bethesda, MD 20892..., DEA, NIDDK, National Institutes of Health, Room 750, 6707 Democracy Boulevard, Bethesda, MD 20892-2542... applications. Place: National Institutes of Health, Two Democracy Plaza, 6707 Democracy Boulevard, Bethesda, MD...

75 FR 20853 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting

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2010-04-21

... National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the..., Eunice Kennedy Shriver, National Institute of Child Health & Human Development, NIH, DHHS, 6100 Executive... Initiatives. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD...

76 FR 66075 - Center for Scientific Review Notice of Closed Meetings

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2011-10-25

... applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting..., Bethesda, MD 20892, (Virtual Meeting). Contact Person: Michael H. Chaitin, PhD, Scientific Review Officer... Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: John C Pugh, PhD...

77 FR 2987 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

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2012-01-20

..., National Institutes of Health, Room 761, 6707 Democracy Boulevard, Bethesda, MD 20892-5452, (301) 594-4719... Democracy Plaza, 6707 Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference Call). Contact Person... Health, Room 756, 6707 Democracy Boulevard, Bethesda, MD 20892-5452, (301) 594-7682, [email protected

Water-quality data for the Ohio River from New Cumberland Dam to Pike Island Dam, West Virginia and Ohio, May-October 1993

USGS Publications Warehouse

Miller, K.F.; Messinger, Terence; Waldron, M.C.; Faulkenburg, C.W.

1996-01-01

This report contains water-quality data for the Ohio River from river mile 51.1 (3.3 miles upstream from New Cumberland Dam) to river mile 84.0 (0.2 miles upstream from Pike Island Dam) that were collected during the summer and fall of 1993. The data were collected to establish the water quality of the Ohio River and to use in assessing the proposed effects of hydropower development on the water quality of the Ohio River. Water quality was determined by a combination of repeated synoptic field measurements, continuous-record monitoring, and laboratory analyses. Synoptic measurements were made along a longitudinal transect with 18 mid-channel sampling sites; cross-sectional transects of water-quality measurements were made at 5 of these sites. Water-quality measurements also were made at two sites located on the back-channel (Ohio) side of Browns Island. At each longitudinal-transect and back-channel sampling site, measurements were made of specific conductance, pH, water temperature, and dissolved oxygen conentration. Longitudinal-transect and back-channel stations were sampled at four depths (at the surface, about 3.3 feet below the surface, middle of the water column, and near the bottom of the river). Cross-sectional transects consisted of three to four detailed vertical profiles of the same characteristics. Water samples were collected from three depths at the mid-channel vertical profile in each cross-sectional transect and were analyzed for concentrations of phytoplankton photosynthetic pigments chlorophyll a and chlorophyll b. Estimates of the depth of light penetration (Secchi-disk transparency) were made at pigment-sampling locations whenever light and river-surface conditions were appropriate. Synoptic sampling usually was completed in 12 hours or less and was repeated 10 times from May through October 1993. Continuous-record monitoring of water quality consisted of hourly measurements of specific conductance, pH, water temperature, and dissolved oxygen

77 FR 56624 - Sunshine Act Meeting Notice

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2012-09-13

... CONSUMER PRODUCT SAFETY COMMISSION Sunshine Act Meeting Notice TIME AND DATE: Wednesday, September 19, 2012, 10 a.m.-12 p.m. PLACE: Room 420, Bethesda Towers, 4330 East West Highway, Bethesda..., Office of the Secretary, U.S. Consumer Product Safety Commission, 4330 East West Highway, Bethesda, MD...

75 FR 12766 - National Center on Minority Health and Health Disparities; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-17

..., Bethesda, MD 20892. (Virtual Meeting) Contact Person: Prabha L. Atreya, PhD, Chief, Office of Scientific... Health, 6706 Democracy Blvd. 800, Bethesda, MD 20892. (Virtual Meeting) Contact Person: Prabha L. Atreya... Democracy Boulevard, Suite 800, Bethesda, MD 20892. (Virtual Meeting) Contact Person: Prabha L. Atreya, PhD...

77 FR 31629 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

... Institutes of Health, Two Democracy Plaza, 6707 Democracy Boulevard, Bethesda, MD 20892 (Telephone Conference..., National Institutes of Health, Room 756, 6707 Democracy Boulevard, Bethesda, MD 20892-5452, (301) 594-7682... 760, 6707 Democracy Boulevard, Bethesda, MD 20892-5452, (301) 594-3993, [email protected] . Name of...

77 FR 7138 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-10

... CONSUMER PRODUCT SAFETY COMMISSION Sunshine Act Meeting Notice TIME AND DATE: Wednesday, February 15, 2012, 10 a.m.-12 p.m. PLACE: Room 410, Bethesda Towers, 4330 East West Highway, Bethesda... of the Secretary, U.S. Consumer Product Safety Commission, 4330 East West Highway, Bethesda, MD 20814...

The Bethesda system for reporting thyroid cytopathology: An experience of 1,382 cases in a community practice setting with the implication for risk of neoplasm and risk of malignancy.

PubMed

Wu, Howard Her-Juing; Rose, Crystal; Elsheikh, Tarik M

2012-05-01

The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has provided a set of uniform diagnostic terminology including benign (B), atypia of undetermined significance (AUS), follicular neoplasm (FN), suspicious for malignancy (SM), malignancy (M), and nondiagnostic (ND) for the interpretation of thyroid fine-needle aspiration (FNA). We applied this terminology on our 1,382 thyroid aspirates in a community practice setting, which included 539 cases of B (39%), 376 cases of AUS (27.2%), 116 cases of FN (8.4%), 37 cases of malignant (2.7%), 36 cases of SM (2.6%), and 278 cases of ND (20.1%). Two hundred twenty-one cases (16%) of thyroid FNA had corresponding follow-up thyroidectomies. Each diagnostic category represented a unique association with risk of malignancy and risk of neoplasm. Based on histologic follow-up, the risk of neoplasm (including benign and malignant neoplasm) was B 14%, AUS 44%, FN 67%, SM 77%, and M 100% and the risk of malignancy was B 3%, AUS 6%, FN 22%, SM 56%, and M 100%. The classification and follow-up recommendation of TBSRTC are appropriate for each category. Both B and AUS are low-risk lesions with low probability of malignancy. FN predicts a higher rate for neoplasm but an intermediate rate for malignancy while SM carries a high risk for malignancy. Copyright © 2011 Wiley-Liss, Inc.

78 FR 5191 - National Institute on Aging; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-24

... review and evaluate grant applications. Place: DoubleTree by Hilton Hotel Bethesda, 8120 Wisconsin Avenue.... to 2:00 p.m. Agenda: To review and evaluate grant applications. Place: DoubleTree by Hilton Hotel... applications. Place: DoubleTree by Hilton Hotel Bethesda, 8120 Wisconsin Avenue, Bethesda, MD 20814. Contact...

78 FR 3883 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-17

... CONSUMER PRODUCT SAFETY COMMISSION Sunshine Act Meeting Notice TIME AND DATE: Wednesday, January 23, 2013, 10:00 a.m.--11:00 a.m. PLACE: Room 420, Bethesda Towers, 4330 East West Highway, Bethesda..., Office of the Secretary, U.S. Consumer Product Safety Commission, 4330 East West Highway, Bethesda, MD...

Outcomes of Bethesda Categories III and IV Thyroid Nodules Over 5 Years and Performance of the Afirma Gene Expression Classifier: A Single-Institution Study.

PubMed

Deaver, Kelsi E; Haugen, Bryan R; Pozdeyev, Nikita; Marshall, Carrie B

2018-05-23

The second edition Bethesda System for Reporting Thyroid Cytology estimates 6-18% malignancy rate of category III (B3) and 10-40% for category IV (B4) nodules; however, reported malignancy rates have considerable variability among institutions. Use of molecular classifiers (including Afirma Gene Expression Classifier, GEC) can be utilized in management of thyroid nodules. Our objective was to analyze malignancy rates of B3 and B4 nodules and determine clinical outcomes of GEC Benign nodules. A retrospective analysis of 2019 thyroid FNAs was performed at the University of Colorado from 2011-2015, including molecular, surgical, and clinical follow-up. Of 2019 FNAs analyzed, 231 (11.4%) were diagnosed as B3 and 80 (4.0%) as B4. GEC was obtained in 54.1% of B3 cases, with nearly half (48.8%) having a Benign result. Surgery was performed in 40.7% B3 cases with a 24.5% malignancy rate, ranging 8-38% by year. In the B4 group, 52.5% underwent molecular testing with 28.6% as GEC Benign. 68.8% of B4 cases underwent surgery with a 20% malignancy rate, ranging 0-42% by year. 73 GEC Benign cases were reviewed: 5 (6.8%) underwent surgery, with none demonstrating malignancy in the target nodule. Size remained stable for most GEC Benign nodules: 75.9% (B3) and 71.4% (B4) with no malignancy on repeat FNA. Our 5-year review demonstrated that malignancy rates of B3 and B4 nodules showed year-to-year variability. We suggest that clinicians use a multi-year average of their institution's malignancy rates to optimally manage patients. Follow-up for GEC Benign cases thus far supports their indolent nature. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

78 FR 21131 - National Center for Advancing Translational Sciences; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-09

... Institutes of Health, 6701 Democracy Blvd., Democracy 1, Room 1084, Bethesda, MD 20892-4874, 301-435-0829...., Democracy 1, Room 1084, Bethesda, MD 20892-4874, 301-435-0829, [email protected] . Name of Committee: National...), National Institutes of Health, 6701 Democracy Blvd., Democracy 1, Room 1084, Bethesda, MD 20892-4874, 301...

New species of Braggia (Hemiptera: Aphididae) on buckwheat in western North America

Treesearch

K. S. Pike; G. Graf; R. G. Foottit; H. E. L. Maw; P. Stary; R. Hammon; D. G. Miller

2009-01-01

Species of Braggia Gillette and Palmer (Hemiptera: Aphididae: Aphidinae: Aphidini) feed on various buckwheat, Eriogonum Michx. (Polygonaceae), species in western North America. Two new species, Braggia columbiana Pike n. sp. from Washington and Oregon and Braggia longicauda Pike n. sp. from Washington, Oregon, and northern California, are proposed. Descriptions,...

Asphalt deposits and oil conditions in southwestern Arkansas: Chapter J in Contributions to economic geology, 1918, Part II, Mineral fuels

USGS Publications Warehouse

Miser, Hugh D.; Purdue, Albert Homer

1919-01-01

Seven asphalt deposits, three of which are in Pike County and four in Sevier County, in southwestern Arkansas, were examined by the writers during the progress of the field work for the De Queen-Caddo Gap folio, which is now in preparation. These deposits are all found at or near the same horizon in the Trinity formation. Only one has so far been developed into a mine from which asphalt has been shipped in commercial quantity. This deposit, which has been described by Hayes, 1 is about 2£ miles south-southeast of Pike, in Pike County. Of the other six deposits only three have been prospected.

Stability Operations: Getting It Right in the Global War on Terrorism

DTIC Science & Technology

2005-03-18

the United States of America (Washington, D.C.: The White House, September 2002), 1 " John Pike, "Where are the Legions? [ SPQR ] Global Deployments of...for a Postconflict Stability Force. Washington, D.C.: United States Institute of Peace Press, 2004. Pike, John. "Where Are the Legions? [ SPQR ] Global

The Segments and Tones of Soyaltepec Mazatec

ERIC Educational Resources Information Center

Beal, Heather D.

2011-01-01

This dissertation describes the segments and tones of Soyaltepec Mazatec, an Oto-Manguean language of southern Mexico virtually undescribed in the literature with the exception of Pike (1956). The preliminary work done by Pike and subsequent analyses by Goldsmith (1990) and Pizer (1994) are reviewed giving evidence that the system is complex and…

Brain-Computer Interfaces: A Gentle Introduction

NASA Astrophysics Data System (ADS)

Graimann, Bernhard; Allison, Brendan; Pfurtscheller, Gert

Stardate 3012.4: The U.S.S. Enterprise has been diverted from its original course to meet its former captain Christopher Pike on Starbase 11. When Captain Jim Kirk and his crew arrive, they find out that Captain Pike has been severely crippled by a radiation accident. As a consequence of this accident Captain Pike is completely paralyzed and confined to a wheelchair controlled by his brain waves. He can only communicate through a light integrated into his wheelchair to signal the answers "yes" or "no". Commodore Mendez, the commander of Starbase 11, describes the condition of Captain Pike as follows: "He is totally unable to move, Jim. His wheelchair is constructed to respond to his brain waves. He can turn it, move it forwards, backwards slightly. Through a flashing light he can say 'yes' or 'no'. But that's it, Jim. That is as much as the poor ever can do. His mind is as active as yours and mine, but it's trapped in a useless vegetating body. He's kept alive mechanically. A battery driven heart. …"

Prevalence and Correlates of Suicidal Behavior Among New Soldiers in the U.S. Army: Results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)

DTIC Science & Technology

2014-01-01

of Psy- chiatry, Uniformed Services University of the Health Sciences , Bethesda, Maryland 2Institute for Social Research, University of Michigan, Ann...Mental Health, Bethesda, Maryland 9Departments of Social and Behavioral Sciences , and Epidemi- ology, Harvard School of Public Health, Boston...Department of Psychiatry, Uniformed Services Uni- versity of the Health Sciences , 4301 Jones Bridge Road, Bethesda, MD 20814. E-mail: robert.ursano

Morphometric analysis of early Eocene Corbisema skeletons (Silicoflagellata) in Mors, Denmark

NASA Astrophysics Data System (ADS)

Tsutsui, Hideto; Jordan, Richard W.; Nishiwaki, Niichi; Nishida, Shiro

2018-02-01

A two-dimensional morphometric programme, recently designed to measure fossil skeletons of the silicoflagellate genus Corbisema, was used to investigate specimens of the C. apiculata-C. triacantha complex found in a sample from the Fur Formation on the island of Mors, Jutland, Denmark. The semi-automated programme measured the lengths of the basal sides and radial spines, the basal side curvature, and the location of the pikes (if present) from a photographic database (N = 469). As a result, two distinct morphological groups were revealed based on their radial spine length : basal side length ratio and the presence or absence of pikes: group A (ratio of 1 : 1.3, no pikes) and group B, with the latter subdivided into B1 (ratio of 1 : 7, with pikes) and B2 (ratio of 1 : 6, no pikes). Group A (C. triacantha sensu lato) possesses a small basal ring with relatively straight basal sides and long radial spines, while group B has a large basal ring with curved basal sides and short radial spines. In B1 specimens (C. apiculata sensu stricto) the pikes are positioned 0 to 1 µm away from the junction point of the strut and basal ring. This would suggest that B1 double skeletons are likely to be in the Star-of-David configuration, while A and B2 double skeletons (which lack pikes) are likely to be in the corner-to-corner configuration. Compared with the previously published biometric studies of extant Stephanocha (Stephanocha speculum complex in the Southern Ocean and S. medianoctisol in the Arctic Ocean), the results are somewhat different: although C. triacantha sensu lato (group A) is similar to the modern species of Stephanocha, the latter have smaller basal ring diameters, whereas specimens of C. apiculata sensu lato (types B1 and B2) have large basal rings. If their cell diameters are calculated, B1 is the largest, with S. speculum being the smallest - about half the size of B1. This could suggest that the relationship between radial spine length and mean basal ring

Geohydrology of, and nitrogen and chloride in, the glacial aquifer, Milford-Matamoras area, Pike County, Pennsylvania

USGS Publications Warehouse

Senior, L.A.

1994-01-01

The glacial aquifer that underlies the Routes 209 and 6 corridor between Milford and Matamoras, Pa., is one of the most productive in Pike County. The aquifer is comprised of unconsolidated glacial outwash and kame-terrace deposits that lie within a glacially carved valley now occupied by the Delaware River. Most businesses and residences along this narrow, 7-mile-long corridor rely on individual wells for water supply and septic systems for waste-water disposal. A study of nutrients and chloride in ground water in the glacial aquifer was conducted to determine the effect of these constituents contributed from septic systems and road runoff on ground-water quality. Sources of nutrients and chloride in the recharge zone upgradient of the aquifer include road and parking-lot runoff, septic systems, and precipitation. Nitrate and chloride from these sources can infiltrate and move in the direction of ground-water flow in the saturated zone of the aquifer. A water-table map based on 29 water levels measured in August 1991 indicates that the direction of ground-water flow is from the edges of the valley toward t he Delaware River but is nearly parallel to the Delaware River in the central area of the valley. The average concentrations of nitrogen and chloride in recharge and total annual loads of nitrogen and chloride to ground water were estimated for six areas with different population densities. These estimates assumed a recharge rate to the glacial aquifer of 20 inches per year and a 15 percent loss of chloride and nitrogen in the atmospheric precipitation to surface runoff. The estimated average concentration of nitrogen in recharge ranged from 2.5 to 10 mg/L (milligrams per liter), which corresponds to a total annual load of nitrogen as ammonium released from septic tanks and present in precipitation was oxidized to nitrate as the dominant nitrogen species in ground water. Contributions of nitrogen from septic tanks were greater than contributions from runoff

Center for the Study of Traumatic Stress 2010 Annual Report: Improving Psychological Health and Resilience Through Trauma Research, Education and Consultation

DTIC Science & Technology

2011-01-01

Health Sciences 4301 Jones Bridge Road Bethesda, MD 20814-4799 Craig H. Llewellyn , M.D. professor Department of Military and emergency Medicine F...Health Sciences,4301 Jones Bridge Road,Bethesda,MD,20814-4799 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND...F. edward Hebert School of Medicine uniformed Services university 4301 Jones Bridge Road Bethesda, MD20814-4799 BG (ret) William T. Bester, RN, MSN

PATHFINDER. Volume 8, Number 5. September/October 2010

DTIC Science & Technology

2010-10-01

Office of Corporate Communications,4600 Sangamore Road, Mail Stop D-54,Bethesda,MD, 20816 -5003 8. PERFORMING ORGANIZATION REPORT NUMBER 9...Agency Office of Corporate Communications 4600 Sangamore Road, Mail Stop D-54 Bethesda, MD 20816 -5003 Telephone: (301) 227-9123, DSN 287-9123 E...Stop D-120, 4600 Sangamore Rd., Bethesda, MD 20816 -5003. Destroy IAW DoDD 5030.59. Removal of this caveat is prohibited. UNCLASSIFIED//LIMITED

Chemical Warfare Study: Summary Report

DTIC Science & Technology

1985-02-01

Performed under subcontract for INSTITUTE FOR DEFENSE ANALYSES Burdeshaw Associates, Ltd. 4701 Sangamore Road Bethesda, Maryland 20816 February 1985...Associates, Ltd. 4701 Sangamore Road Bethesda, Maryland 20816 11. CONTROLUNG OFFICE NAME AND ADDRESS Office of the 0nder Secretary of Defense for...Associates, Ltd. 4701 Sangamore Road Bethesda, Maryland 20816 February 1985 IDA INSTITUTE FOR DEFENSE ANALYSES Contract MDA 903 84 C 0031 Task T-3-200 o

78 FR 25752 - National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-02

..., Two Democracy Plaza, 951, 6707 Democracy Boulevard, Bethesda, MD 20892, (Virtual Meeting). Contact..., Two Democracy Plaza, Suite 920, 6707 Democracy Boulevard, Bethesda, MD 20892, (Virtual Meeting...

Climate and Physiography Predict Mercury Concentrations in Game Fish Species in Quebec Lakes Better than Anthropogenic Disturbances.

PubMed

Lucotte, Marc; Paquet, Serge; Moingt, Matthieu

2016-05-01

The fluctuations of mercury levels (Hg) in fish consumed by sport fishers in North-Eastern America depend upon a plethora of interrelated biological and abiological factors. To identify the dominant factors ultimately controlling fish Hg concentrations, we compiled mercury levels (Hg) during the 1976-2010 period in 90 large natural lakes in Quebec (Canada) for two major game species: northern pike (Esox lucius) and walleye (Sander vitreus). Our statistical analysis included 28 geographic information system variables and 15 climatic variables, including sulfate deposition. Higher winter temperatures explained 36% of the variability in higher walleye growth rates, in turn accounting for 54% of the variability in lower Hg concentrations. For northern pike, the dominance of a flat topography in the watershed explained 31% of the variability in lower Hg concentrations. Higher mean annual temperatures explained 27% of the variability in higher pike Hg concentrations. Pelagic versus littoral preferred habitats for walleye and pike respectively could explain the contrasted effect of temperature between the two species. Heavy logging could only explain 2% of the increase in walleye Hg concentrations. The influence of mining on fish Hg concentrations appeared to be masked by climatic effects.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larsson, P.; Okla, L.; Collvin, L.

Levels of persistent pollutants, including PCBs, [Sigma]DDT, and [gamma]-hexachlorocyclohexane, were examined in a pike population inhabiting a eutrophic lake in southern Scandinavia. For females, levels of persistent pollutants decreased linearly with age, weight, or length. This decline was ascribed to the seasonal elimination of the lipophilic pollutants in roe, which contained up to 10 times higher fat levels compared to muscle and over 10 times the amounts of pollutants. Male pike contained higher levels of pollutants than females, probably due to the lower elimination via gonadal products, as germinal tissue constitutes only 2% of the male total body weight andmore » has a lower fat content than ovaries. Female germinal tissue can account for as much as 15% of the body weight. No major fat deposits other than those in germinal tissue were found in pike, which also had a low muscle fat content, suggesting that the importance of roe elimination in removing pollutants may be greater in pike than in salmonids. Uptake of persistent pollutants can vary greatly within a species, owing to differences in sex, age, and so forth, as well as between species, owing to differences in fat deposition strategies.« less

75 FR 21005 - National Advisory Council on the National Health Service Corps; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-22

... (BCRS), discuss recruitment and marketing strategies for the NHSC, and address current workforce issues.... Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852, Phone...

Stress and Coping with War: Support Providers and Casualties of Operations Desert Shield/Storm

DTIC Science & Technology

1992-07-01

DEPARTMENT OF PSYCHIATRY F. EDWARD HEBERT SCHOOL OF MEDICINE UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES BETHESDA, MARYLAND 20814-4799 2v 92...NUMBER Uniformed Services University of the Health Sciences 4301 Jones Bridge Road Bethesda, MD 20814-4799 .TF-S~br6 Ftlf*,i’.* riIiPIi;; A;i or fIAMr...STORM DPRMN .... PSYCHIATRY ,I- F. EDWARD HEBERT SCHOOL OF MEDICINE UNIFORMED SERVICES UNIVERSTIY OF THE HEALTH SCIENCES BETHESDA, MARYLAND 20814-4799

National Oceanographic Fleet Platform Characteristics

DTIC Science & Technology

1992-01-01

Hydrographic/Topographic Center, (Attn: MCC Mail Stop D44), 4600 Sangamore Road, Bethesda, Maryland 20816 -5003, commercial (301) 227-3147 or 7 LEX 898334, DMAHTC...Stop D44), 4600 Sangamore Road, Bethesda, Maryland 20816 -5003, commercial (301) 227-3147 or TELEX 898334, DMAHTC, Washington, DC. Military users may use...Mail Stop D44), 4600 Sangamore Road, Bethesda, Maryland 20816 -5003, commercial (301) 227-3147 or TELEX 898334, DMAHTC, Washington, DC. Military users

75 FR 9910 - National Center for Research Resources; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-04

... applications. Place: 6701 Democracy Blvd., Democracy 1, 1082, Bethesda, MD (Virtual Meeting). Contact Person... Research Resources, Office of Review, 6701 Democracy Blvd, Rm. 1082, Bethesda, MD 20892, 301-435-0811...

76 FR 27069 - National Cancer Institute; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

... Interactions. Place: Double Tree by Hilton Hotel Bethesda, The Grand Ball Room, 8120 Wisconsin Avenue, Bethesda... show one form of identification (for example, a government-issued photo ID, driver's license, or...

77 FR 59940 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-01

...: National Institutes of Health, One Democracy Plaza, 6701 Democracy Boulevard, Bethesda, MD 20892... Branch, DEA, NIDDK, National Institutes of Health, Room 758, 6707 Democracy Boulevard, Bethesda, MD 20892... applications. [[Page 59941

Toward a National Standards Strategy Conference Report

DTIC Science & Technology

1999-02-01

conducted by the CDRH (FDA) identifies four discernible characteristics relative to products and technology in the next decade. 1. Medical hardware seems...Altman FDA/ CDRH 2094 Gaither Rd. HFZ-80 Rockville, MD 20850 USA Telephone: 301/594-4766 Fax: 301/827-0193 Email: mra@cdrh.fda.gov F. Alan Andersen...642^948 Fax: 212/840-2298 Email: amarasco@ansi.org B-10 Donald Marlowe FDA/ CDRH /OST/OD 12725 Twinbrook Pkwy. HFZ-100 Rockville, MD 20850 USA

75 FR 18216 - National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

..., Democracy II, 6707 Democracy Blvd, Suite 900, Bethesda, MD 20892. Contact Person: John K. Hayes, PhD, Scientific Review Officer, 6707 Democracy Boulevard, Suite 959, Democracy Two, Bethesda, MD 20892, 301-451...

77 FR 59934 - National Center for Advancing Translational Sciences; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-01

... of Health, 6701 Democracy Blvd., Room 1082, Bethesda, MD 20892-4874, 301-435- 0811, [email protected], National Institutes of Health, 6701 Democracy Blvd., Room 1082, Bethesda, MD 20892-4874, 301-435- 0811...

76 FR 11798 - National Center for Research Resources; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-03

... Blvd., 1064, Bethesda, MD 20892-4874 (Telephone Conference Call). Contact Person: Guo Zhang, PhD... Health, 6701 Democracy Blvd., Dem. 1, Room 1064, MSC 4874, Bethesda, MD 20892-4874, 301-435-0812, zhanggu...

76 FR 36556 - National Center for Research Resources; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

... proposals. Place: National Institutes of Health/NCRR/OR, Democracy 1, 6701 Democracy Blvd., 1064, Bethesda... Democracy Plaza, Room 1064, MSC 4874, Bethesda, MD 20892-4874, 301-435-0812, [email protected] . Name of...

75 FR 43993 - National Institute of Biomedical Imaging and Bioengineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-27

... Level), Bethesda, MD 20817. Contact Person: Anthony Demsey, PhD, Director, National Institute of... Level), Bethesda, MD 20817. Closed: 1 p.m. to 3 p.m. Agenda: To review and evaluate grant applications...

Biogeochemical environments of streambed-sediment pore waters withand without arsenic enrichment in a sedimentary rock terrain, New Jersey Piedmont, USA

USGS Publications Warehouse

Mumford, Adam C.; Barringer, Julia L.; Reilly, Pamela A.; Eberl, Dennis D.; Blum, Alex E.; Young, Lily Y.

2015-01-01

Release of arsenic (As) from sedimentary rocks has resulted in contamination of groundwater in aquifers of the New Jersey Piedmont Physiographic Province, USA; the contamination also may affect the quality of the region's streamwater to which groundwater discharges. Biogeochemical mechanisms involved in the release process were investigated in the streambeds of Six Mile Run and Pike Run, tributaries to the Millstone River in the Piedmont. At Six Mile Run, streambed pore water and shallow groundwater were low or depleted in oxygen, and contained As at concentrations greater than 20μg/L. At Pike Run, oxidizing conditions were present in the streambed, and the As concentration in pore water was 2.1μg/L. The 16S rRNA gene and the As(V) respiratory reductase gene, arrA, were amplified from DNA extracted from streambed pore water at both sites and analyzed, revealing that distinct bacterial communities that corresponded to the redox conditions were present at each site. Anaerobic enrichment cultures were inoculated with pore water from gaining reaches of the streams with acetate and As(V). As(V) was reduced by microbes to As(III) in enrichments with Six Mile Run pore water and groundwater, whereas no reduction occurred in enrichments with Pike Run pore water. Cloning and sequencing of the arrA gene indicated 8 unique operational taxonomic units (OTUs) at Six Mile Run and 11 unique OTUs at Pike Run, which may be representative of the arsenite oxidase gene arxA. Low-oxygen conditions at Six Mile Run have favored microbial As reduction and release, whereas release was inhibited by oxidizing conditions at Pike Run.

The use of the Bethesda terminology in thyroid fine-needle aspiration results in a lower rate of surgery for nonmalignant nodules: a report from a reference center in Turkey.

PubMed

Ozluk, Yasemin; Pehlivan, Esmehan; Gulluoglu, Mine G; Poyanli, Arzu; Salmaslioglu, Artur; Colak, Nese; Kapran, Yersu; Yilmazbayhan, Dilek

2011-12-01

The Bethesda system (BS) for reporting thyroid fine-needle aspiration (FNA), which classifies nodules as nondiagnostic (ND), benign (B), atypia/follicular lesion of undetermined significance (AUS/FLUS), suspicious for follicular neoplasm (SFN/FN), suspicious for malignancy (SFM), or malignant (M), uses clinically valuable management guidelines. The authors employed a similar in-house classification system (IS) for thyroid FNAs, using the categories of ND, B, suspicious follicular cells (SFC), follicular lesion/neoplasm (FL/FN), SFM, and M. The authors compared IS and BS, and assessed the utility of BS in clinical practice. A total of 581 nodules with cytological/histological follow-up were examined and indeterminate lesions by BS were reclassified. The sensitivity and specificity for malignancy using IS were similar to that of BS (77% vs 99%). However, when SFN/FN and SFM were both considered positive, the results for IS and BS were as follows: sensitivity, 85% versus 85%; specificity, 87% versus 94%; and diagnostic accuracy, 86% versus 90%, respectively. Discrepancies between cytological and histological data were evident in 35 cases among all categories of BS except AUS/FLUS. The rate of surgery for nonmalignant nodules was lesser (20% vs 9%) by BS. Among 34 AUS/FLUS cases with follow-up data, hypocellularity was the case in 11 (46%) nonneoplastic and 10 (100%) neoplastic nodules. The use of BS results in a lower rate of surgery for nonmalignant nodules even though patients with borderline cytopathologic features are still encountered. AUS/FLUS category can be separated into subgroups according to the factors causing difficulties in the interpretation. There is a need of accumulation of AUS/FLUS cases to do further evaluations and studies.

Fish introductions reveal the temperature dependence of species interactions

PubMed Central

Hein, Catherine L.; Öhlund, Gunnar; Englund, Göran

2014-01-01

A major area of current research is to understand how climate change will impact species interactions and ultimately biodiversity. A variety of environmental conditions are rapidly changing owing to climate warming, and these conditions often affect both the strength and outcome of species interactions. We used fish distributions and replicated fish introductions to investigate environmental conditions influencing the coexistence of two fishes in Swedish lakes: brown trout (Salmo trutta) and pike (Esox lucius). A logistic regression model of brown trout and pike coexistence showed that these species coexist in large lakes (more than 4.5 km2), but not in small, warm lakes (annual air temperature more than 0.9–1.5°C). We then explored how climate change will alter coexistence by substituting climate scenarios for 2091–2100 into our model. The model predicts that brown trout will be extirpated from approximately half of the lakes where they presently coexist with pike and from nearly all 9100 lakes where pike are predicted to invade. Context dependency was critical for understanding pike–brown trout interactions, and, given the widespread occurrence of context-dependent species interactions, this aspect will probably be critical for accurately predicting climate impacts on biodiversity. PMID:24307673

Before-after, control-impact analysis of evidence for the impacts of water level on Walleye, Northern Pike and Yellow Perch in lakes of the Rainy-Namakan complex (MN, USA and ON, CA).

PubMed

Larson, James H; Maki, Ryan P; Vondra, Benjamin A; Peterson, Kevin E

2018-01-01

Water level (WL) fluctuations in lakes influence many aspects of ecosystem processes. Concern about the potential impact of WL fluctuations on fisheries was one of the factors that motivated the decision in 2000 to alter the management of WL in the Rainy-Namakan reservoir complex (on the border between the U.S. state of Minnesota and the Canadian province of Ontario). We used a Before-After, Control-Impact (BACI) framework to identify potential impacts of the change in WL management to Walleye, Northern Pike and Yellow Perch catch per unit effort (CPUE). The CPUE of these species from 1990-1999 and from 2005-2014 were compared in four impact lakes (Lake Kabetogama, Namakan Lake, Rainy Lake and Sand Point Lake) and two control lakes (Lake of the Woods and Lake Vermilion) using a simple Bayesian model. Changes in fish CPUE in the impact lakes were often similar to changes that occurred in at least one control lake. The only change that was not similar to changes in control lakes was an increase of Yellow Perch in Lake Kabetogama. The two control lakes often differed substantially from each other, such that if only one had been available our conclusions about the role of WL management on fisheries would be very different. In general, identifying cause-and-effect relationships in observational field data is very difficult, and the BACI analysis used here does not specify a causative mechanism, so co-occurring environmental and management changes may obscure the effect of WL management.

Mapping, Charting and Geodesy Handbook

DTIC Science & Technology

1994-07-15

Air-526 at (703) 604-3380 ext 8102 or 8118 [DSN 664, -.Of a copy of DMAI 8660.10 write DMA, Attn: AMO, Stop D-2, 4600 Sangamore Rd., Bethesda MD 20816 ...Instructions, Lists, and Handbooks from DMA, Attn: AMO, Stop D-2, 4600 Sangamore Rd., Bethesda MD 20816 or call (301) 227-2026 DSN [287] or fax (301) 227...DMA Combat Support Center Attn: CCOR, Stop D-16 6001 MacArthur Blvd. Bethesda, MD 20816 fax (301) 227-2498 DSN 287-2498 3. NOT SO ROUTINE ORDERING

76 FR 15988 - National Institute of Biomedical Imaging and Bioengineering; Notice of Meeting

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2011-03-22

... assistance, such as sign language interpretation or other reasonable accommodations, should notify the... plan. Place: Bethesda Marriott Suites, 6711 Democracy Boulevard, Independence Room (2nd Level... proposals. Place: Bethesda Marriott Suites, 6711 Democracy Boulevard, Independence Room (2nd Level...

77 FR 14405 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

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2012-03-09

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of...: National Institutes of Health, Two Democracy Plaza, 6707 Democracy Boulevard, Bethesda, MD 20892... Branch, DEA, NIDDK, National Institutes of Health, Room 758, 6707 Democracy Boulevard, Bethesda, MD 20892...

76 FR 69748 - National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting

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2011-11-09

... Grossman, DDS, Scientific Review Officer, National Institute of Biomedical Imagin and Bioengineering... Bethesda Metro Station, Bethesda, MD 20814. Contact Person: Ruth Grossman, DDS, Scientific Review Officer...Continental Chicago, 505 North Michigan Avenue, Chicago, IL. Contact Person: Ruth Grossman, DDS, Scientific...

77 FR 16248 - Center for Scientific Review; Notice of Closed Meetings

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2012-03-20

... (Virtual Meeting). Contact Person: Kenneth A Roebuck, Ph.D., Scientific Review Officer, Center for... Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Robert Freund, Ph.D., Scientific.... Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting...

Pathfinder, v7 n1, Jan/Feb 2009. Making an Intelligence Difference

DTIC Science & Technology

2009-02-01

ORGANIZATION NAME(S) AND ADDRESS(ES) National Geospatial-Intelligence Agency,Office of Corporate Communications,4600 Sangamore Road ,Bethesda,MD, 20816 ...Published by the National Geospatial-Intelligence Agency Office of Corporate Communications 4600 Sangamore Road, Mail Stop D-54 Bethesda, MD 20816

Coexistence of behavioural types in an aquatic top predator: a response to resource limitation?

PubMed

Kobler, Alexander; Klefoth, Thomas; Mehner, Thomas; Arlinghaus, Robert

2009-10-01

Intra-population variation in behaviour unrelated to sex, size or age exists in a variety of species. The mechanisms behind behavioural diversification have only been partly understood, but density-dependent resource availability may play a crucial role. To explore the potential coexistence of different behavioural types within a natural fish population, we conducted a radio telemetry study, measuring habitat use and swimming activity patterns of pike (Esox lucius), a sit-and-wait predatory fish. Three behavioural types co-occurred in the study lake. While two types of fish only selected vegetated littoral habitats, the third type opportunistically used all habitats and increased its pelagic occurrence in response to decreasing resource biomasses. There were no differences in size, age or lifetime growth between the three behavioural types. However, habitat-opportunistic pike were substantially more active than the other two behavioural types, which is energetically costly. The identical growth rates exhibited by all behavioural types indicate that these higher activity costs of opportunistic behaviour were compensated for by increased prey consumption in the less favourable pelagic habitat resulting in approximately equal fitness of all pike groups. We conclude that behavioural diversification in habitat use and activity reduces intraspecific competition in preferred littoral habitats. This may facilitate the emergence of an ideal free distribution of pike along resource gradients.

76 FR 23829 - Center for Scientific Review; Notice of Closed Meetings

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2011-04-28

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Telephone... Review, National Institutes of Health, 6701 Rockledge Drive, Room 2176, MSC 7818, Bethesda, MD 20892, 301...

77 FR 55851 - Center for Scientific Review; Notice of Closed Meetings

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2012-09-11

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892... Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5217A, MSC 7846, Bethesda, MD...

75 FR 1796 - Center for Scientific Review; Notice of Closed Meetings

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2010-01-13

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... grant applications. Place: National Institute of Health, 6710 Rockledge Drive, Bethesda, MD 20892... Review, National Institutes of Health, 6701 Rockledge Drive, Room 2212, MSC 7890, Bethesda, MD 20892...

78 FR 48880 - Center for Scientific Review; Notice of Closed Meetings

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2013-08-12

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892... Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5194, MSC 7846, Bethesda, MD...

76 FR 16798 - National Institutes of Health

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2011-03-25

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review.... Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Telephone Conference..., National Institutes of Health, 6701 Rockledge Drive, Room 4136, MSC 7850, Bethesda, MD 20892, (301) 435...

75 FR 20852 - Center for Scientific Review; Notice of Closed Meetings

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2010-04-21

...: Biological Chemistry and Macromolecular Biophysics. Date: May 26-27, 2010. Time: 11 a.m. to 10 p.m. Agenda..., Bethesda, MD 20892 (Virtual Meeting). Contact Person: Donald L. Schneider, PhD, Scientific Review Officer..., Bethesda, MD 20892 (Telephone Conference Call). [[Page 20853

77 FR 293 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-04

...., as amended. The grant applications and the discussions could disclose confidential trade secrets or... with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of... grant applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue...

78 FR 38999 - Center for Scientific Review; Notice of Closed Meetings

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2013-06-28

..., (Virtual Meeting). Contact Person: Elena Smirnova, Ph.D., Scientific Review Officer, Center for Scientific... of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: Kenneth A... Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: Krish...

77 FR 66623 - National Institute on Minority Health and Health Disparities; Notice of Closed Meeting

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2012-11-06

... and Health Disparities Special Emphasis Panel; NIMHD Community-Based Participatory Research (CBPR... Marriott Suites, 6711 Democracy Boulevard, Bethesda, MD 20817. Contact Person: Robert Nettey, M.D., Chief... of Health, 6707 Democracy Blvd., Suite 800, Bethesda, MD 20892, (301) 496-3996, [email protected

77 FR 48527 - Center for Scientific Review; Notice of Closed Meetings

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2012-08-14

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 4150, MSC 7806, Bethesda, MD... Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person...

75 FR 61766 - Center For Scientific Review; Notice of Closed Meetings

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2010-10-06

... grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892... Review, National Institutes of Health, 6701 Rockledge Drive, Room 3211, MSC 7808, Bethesda, MD 20892, 301..., Member Conflict: Child Psychopathology and Developmental Disabilities. Date: October 25, 2010. Time: 9 a...

78 FR 40756 - Center for Scientific Review; Notice of Closed Meetings

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2013-07-08

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892... Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5186, MSC 7846, Bethesda, MD...

Drug Testing: MedlinePlus Lab Test Information

MedlinePlus

... Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Resource Guide: Screening for Drug Use in General Medical ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated on 11 October 2017

77 FR 19677 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-02

... Institutes of Health, Two Democracy Plaza, 6707 Democracy Boulevard, Bethesda, MD 20892 (Telephone Conference..., National Institutes of Health, Room 760, 6707 Democracy Boulevard, Bethesda, MD 20892-5452, (301) 594-3993... and evaluate grant applications. Place: National Institutes of Health, Two Democracy Plaza, 6707...

78 FR 41939 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-12

...: National Institutes of Health, Two Democracy Plaza, 6707 Democracy Boulevard, Bethesda, Md 20892 (Telephone..., Dea, Niddk, National Institutes of Health, Room 748, 6707 Democracy Boulevard, Bethesda, MD 20892-5452... evaluate grant applications. Place: National Institutes of Health, Two Democracy Plaza, 6707 Democracy...

Pathfinder. Volume 8, Number 4, July/August 2010

DTIC Science & Technology

2010-08-01

Intelligence Agency,4600 Sangamore Road, Mail Stop D-54,Bethesda,MD, 20816 -5003 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING...Intelligence Agency Office of Corporate Communications 4600 Sangamore Road, Mail Stop D-54 Bethesda, MD 20816 -5003 Telephone: (301) 227-7388