Sample records for russak rita nmmela

  1. Lens proteome map and alpha-crystallin profile of the catfish Rita rita.

    PubMed

    Mohanty, Bimal Prasanna; Bhattacharjee, Soma; Das, Manas Kumar

    2011-02-01

    Crystallins are a diverse group of proteins that constitute nearly 90% of the total soluble proteins of the vertebrate eye lens and these tightly packed crystallins are responsible for transparency of the lens. These proteins have been studied in different model and non-model species for understanding the modifications they undergo with ageing that lead to cataract, a disease of protein aggregation. In the present investigation, we studied the lens crystallin profile of the tropical freshwater catfish Rita rita. Profiles of lens crystallins were analyzed and crystallin proteome maps of Rita rita were generated for the first time. alphaA-crystallins, member of the alpha-crystallin family, which are molecular chaperons and play crucial role in maintaining lens transparency were identified by 1- and 2-D immunoblot analysis with anti-alphaA-crystallin antibody. Two protein bands of 19-20 kDa were identified as alphaA-crystallins on 1-D immunoblots and these bands separated into 10 discrete spots on 2-D immunoblot. However, anti-alphaB-crystallin and antiphospho-alphaB-crystallin antibodies were not able to detect any immunoreactive bands on 1- and 2-D immunoblots, indicating alphaB-crystallin was either absent or present in extremely low concentration in Rita rita lens. Thus, Rita rita alpha-crystallins are more like that of the catfish Clarias batrachus and the mammal kangaroo in its alphaA- and alphaB-crystallin content (contain low amount from 5-9% of alphaB-crystallin) and unlike the dogfish, zebrafish, human, bovine and mouse alpha-crystallins (contain higher amount of alphaB-crystallin from 25% in mouse and bovine to 85% in dogfish). Results of the present study can be the baseline information for stimulating further investigation on Rita rita lens crystallins for comparative lens proteomics. Comparing and contrasting the alpha-crystallins of the dogfish and Rita rita may provide valuable information on the functional attributes of alphaA- and alphaB-isoforms, as

  2. Complete mitochondrial genome of the Freshwater Catfish Rita rita (Siluriformes, Bagridae).

    PubMed

    Lashari, Punhal; Laghari, Muhammad Younis; Xu, Peng; Zhao, Zixia; Jiang, Li; Narejo, Naeem Tariq; Deng, Yulin; Sun, Xiaowen; Zhang, Yan

    2015-01-01

    The complete mitochondrial genome of Catfish, Rita rita, was isolated by LA PCR (TakaRa LAtaq, Dalian, China); and sequenced by Sanger's method to obtain the complete mitochondrial genome, which is listed Critically Endangered and Red Listed species. The complete mitogenome was 16,449 bp in length and contains 13 typical vertebrate protein-coding genes, 2 rRNA and 22 tRNA genes. The whole genome base composition was estimated to be 33.40% A, 27.43% C, 14.26% G and 24.89% T. The complete mitochondrial genome of catfish, Rita rita provides the basis for genetic breeding and conservation studies.

  3. Chk2 mediates RITA-induced apoptosis.

    PubMed

    de Lange, J; Verlaan-de Vries, M; Teunisse, A F A S; Jochemsen, A G

    2012-06-01

    Reactivation of the p53 tumor-suppressor protein by small molecules like Nutlin-3 and RITA (reactivation of p53 and induction of tumor cell apoptosis) is a promising strategy for cancer therapy. The molecular mechanisms involved in the responses to RITA remain enigmatic. Several groups reported the induction of a p53-dependent DNA damage response. Furthermore, the existence of a p53-dependent S-phase checkpoint has been suggested, involving the checkpoint kinase Chk1. We have recently shown synergistic induction of apoptosis by RITA in combination with Nutlin-3, and we observed concomitant Chk2 phosphorylation. Therefore, we investigated whether Chk2 contributes to the cellular responses to RITA. Strikingly, the induction of apoptosis seemed entirely Chk2 dependent. Transcriptional activity of p53 in response to RITA required the presence of Chk2. A partial rescue of apoptosis observed in Noxa knockdown cells emphasized the relevance of p53 transcriptional activity for RITA-induced apoptosis. In addition, we observed an early p53- and Chk2-dependent block of DNA replication upon RITA treatment. Replicating cells seemed more prone to entering RITA-induced apoptosis. Furthermore, the RITA-induced DNA damage response, which was not a secondary effect of apoptosis induction, was strongly attenuated in cells lacking p53 or Chk2. In conclusion, we identified Chk2 as an essential mediator of the cellular responses to RITA.

  4. Chk2 mediates RITA-induced apoptosis

    PubMed Central

    de Lange, J; Verlaan-de Vries, M; Teunisse, A F A S; Jochemsen, A G

    2012-01-01

    Reactivation of the p53 tumor-suppressor protein by small molecules like Nutlin-3 and RITA (reactivation of p53 and induction of tumor cell apoptosis) is a promising strategy for cancer therapy. The molecular mechanisms involved in the responses to RITA remain enigmatic. Several groups reported the induction of a p53-dependent DNA damage response. Furthermore, the existence of a p53-dependent S-phase checkpoint has been suggested, involving the checkpoint kinase Chk1. We have recently shown synergistic induction of apoptosis by RITA in combination with Nutlin-3, and we observed concomitant Chk2 phosphorylation. Therefore, we investigated whether Chk2 contributes to the cellular responses to RITA. Strikingly, the induction of apoptosis seemed entirely Chk2 dependent. Transcriptional activity of p53 in response to RITA required the presence of Chk2. A partial rescue of apoptosis observed in Noxa knockdown cells emphasized the relevance of p53 transcriptional activity for RITA-induced apoptosis. In addition, we observed an early p53- and Chk2-dependent block of DNA replication upon RITA treatment. Replicating cells seemed more prone to entering RITA-induced apoptosis. Furthermore, the RITA-induced DNA damage response, which was not a secondary effect of apoptosis induction, was strongly attenuated in cells lacking p53 or Chk2. In conclusion, we identified Chk2 as an essential mediator of the cellular responses to RITA. PMID:22158418

  5. Antibacterial properties of the skin mucus of the freshwater fishes, Rita rita and Channa punctatus.

    PubMed

    Kumari, U; Nigam, A K; Mitial, S; Mitial, A K

    2011-07-01

    The skin mucus of Rita rita and Channa punctatus was investigated to explore the possibilities of its antibacterial properties. Skin mucus was extracted in acidic solvents (0.1% trifluoroacetic acid and 3% acetic acid) and in triple distilled water (aqueous medium). The antibacterial activity of the mucus extracts was analyzed, using disc diffusion method, against five strains of bacteria--the Gram-positive Staphylococcus aureus and Micrococcus luteus; and the Gram negative Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi. In both Rita rita and Channa punctatus, the skin mucus extracted in acidic solvents as well as in aqueous medium show antibacterial activity against Staphylococcus aureus and Micrococcus luteus. Nevertheless, the activity is higher in acidic solvents than that in aqueous medium. The acidic mucus extracts of Rita rita, show antibacterial activity against Salmonella typhi as well. The results suggest that fish skin mucus have bactericidal properties and thus play important role in the protection of fish against the invasion of pathogens. Fish skin mucus could thus be regarded as a potential source of novel antibacterial components.

  6. Proteomic profiling of white muscle from freshwater catfish Rita rita.

    PubMed

    Mohanty, Bimal Prasanna; Mitra, Tandrima; Banerjee, Sudeshna; Bhattacharjee, Soma; Mahanty, Arabinda; Ganguly, Satabdi; Purohit, Gopal Krishna; Karunakaran, Dhanasekar; Mohanty, Sasmita

    2015-06-01

    Muscle tissues contribute 34-48 % of the total body mass in fish. Proteomic analysis enables better understanding of the skeletal muscle physiology and metabolism. A proteome map reflects the general fingerprinting of the fish species and has the potential to identify novel proteins which could serve as biomarkers for many aspects of aquaculture including fish physiology and growth, flesh quality, food safety and aquatic environmental monitoring. The freshwater catfish Rita rita of the family Bagridae inhabiting the tropical rivers and estuaries is an important food fish with high nutritive value and is also considered a species of choice in riverine pollution monitoring. Omics information that could enhance utility of this species in molecular research is meager. Therefore, in the present study, proteomic analysis of Rita rita muscle has been carried out and functional genomics data have been generated. A reference muscle proteome has been developed, and 23 protein spots, representing 18 proteins, have been identified by MALDI-TOF/TOF-MS and LC-MS/MS. Besides, transcript information on a battery of heat shock proteins (Hsps) has been generated. The functional genomics information generated could act as the baseline data for further molecular research on this species.

  7. Realizing the full potential of a RITA spectrometer

    NASA Astrophysics Data System (ADS)

    Lefmann, K.; Niedermayer, Ch.; Abrahamsen, A. B.; Bahl, C. R. H.; Christensen, N. B.; Jacobsen, H. S.; Larsen, T. L.; Häfliger, P.; Filges, U.; Rønnow, H. M.

    2006-11-01

    The “re-invented triple-axis spectrometer (RITA) concept has existed for a decade. Recent developments at RITA-2 at PSI, have revealed more of the potential of this instrument class. We demonstrate the performance of the multi-blade imaging mode, which has been applied e.g. to studies of dispersion relations and emphasize the power of this mode in combination with the low background of RITA-2. In addition, we present other ways of utilizing the position sensitive detector in a RITA instrument. Simulations of a planned upgrade of the guide-monochromator system at RITA-2 have shown a potential to increase the flux at the sample position by a factor 5.

  8. Morphological observation and length-weight relationship of critically endangered riverine catfish Rita rita (Hamilton).

    PubMed

    Amin, M R; Mollah, M F A; Taslima, K; Muhammadullah

    2014-01-15

    The experiment was conducted to investigate the morphological status of the critically endangered riverine catfish Rita rita using morphometric and meristic traits. About 158 species of Rita were collected from the old Brahmaputra river in Mymensingh district and were studied in the laboratory of the Fisheries Biology and Genetics Department, Bangladesh Agricultural University. Measurement of length and weight of Rita were recorded by using measuring scale and electric balance respectively. Significant curvilinear relationship existed between total length and other morphometric characters and between head length and other characters of the head. Relationships between total length and various body measurements of the fish were highly significant (p < 0.01) except the relationship between total length and pelvic fin length of male fish (p < 0.05). In case of meristic characters-dorsal fin rays, pelvic fin rays, pectoral fin rays, anal fin rays, caudal fin rays, number of vertebrae and branchiostegal rays were found to be more or less similar except slight differences. The values of condition factors (k) in the total length body-weight relationships for female and male were found to be 0.41 and 0.38, respectively. The mean values of relative condition factors (kn) were 1.0 and 1.005 for female and male, respectively.

  9. RITA inhibits growth of human hepatocellular carcinoma through induction of apoptosis.

    PubMed

    Wang, Haihe; Chen, Guofu; Wang, Hongzhi; Liu, Chunbo

    2013-01-01

    RBP-J-interacting and tubulin-associated (RITA) is a novel RBP-J-interacting protein that downregulates Notch-mediated transcription. The current study focuses on the antitumor effect of RITA in human hepatocellular carcinoma (HCC) and aims to explore its molecular mechanism. Thirty paired HCC and adjacent non-tumoral liver samples were analyzed by real-time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). RITA overexpression was induced by transfection of a pcDNA3.1-Flag-RITA plasmid into HepG2 cells. RITA knockdown was achieved by siRNA transfection. mRNA and protein expression of target genes were quantified by qRT-PCR and Western blotting, respectively. Cell proliferation and apoptosis were measured using MTT assay and flow cytometry. Our results demonstrate that adjacent nontumoral liver samples exhibited increased RITA expression compared to HCC tissues (p < 0.05); RITA levels were associated with tumor differentiation status. Overexpression of RITA suppressed cell proliferation and promoted early apoptosis, while its silencing promoted cell growth dramatically (p < 0.05). RITA overexpression upregulated p53 and reduced cyclin E levels, whereas silencing of RITA had the opposite effect on p53 and cyclin E expression. Our in vitro results represent the first evidence that RITA might suppress tumor growth and induce apoptosis in HCCs, and may be a potent antitumoral agent for HCC treatment that deserves further exploration.

  10. Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance.

    PubMed

    Bu, Yiwen; Cai, Guoshuai; Shen, Yi; Huang, Chenfei; Zeng, Xi; Cao, Yu; Cai, Chuan; Wang, Yuhong; Huang, Dan; Liao, Duan-Fang; Cao, Deliang

    2016-12-28

    Inactivation of p53 occurs frequently in various cancers. RITA is a promising anticancer small molecule that dissociates p53-MDM2 interaction, reactivates p53 and induces exclusive apoptosis in cancer cells, but acquired RITA resistance remains a major drawback. This study found that the site-differential phosphorylation of nuclear factor-κB (NF-κB) RelA/p65 creates a barcode for RITA chemosensitivity in cancer cells. In naïve MCF7 and HCT116 cells where RITA triggered vast apoptosis, phosphorylation of RelA/p65 increased at Ser536, but decreased at Ser276 and Ser468; oppositely, in RITA-resistant cells, RelA/p65 phosphorylation decreased at Ser536, but increased at Ser276 and Ser468. A phosphomimetic mutation at Ser536 (p65/S536D) or silencing of endogenous RelA/p65 resensitized the RITA-resistant cells to RITA while the phosphomimetic mutant at Ser276 (p65/S276D) led to RITA resistance of naïve cells. In mouse xenografts, intratumoral delivery of the phosphomimetic p65/S536D mutant increased the antitumor activity of RITA. Furthermore, in the RITA-resistant cells ATP-binding cassette transporter ABCC6 was upregulated, and silencing of ABCC6 expression in these cells restored RITA sensitivity. In the naïve cells, ABCC6 delivery led to RITA resistance and blockage of p65/S536D mutant-induced RITA sensitivity. Taken together, these data suggest that the site-differential phosphorylation of RelA/p65 modulates RITA sensitivity in cancer cells, which may provide an avenue to manipulate RITA resistance. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  11. AmeriFlux US-SRC Santa Rita Creosote

    DOE Data Explorer

    Kurc, Shirley [University of Arizona

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-SRC Santa Rita Creosote. Site Description - Part of the Santa Rita Experimental Range since 1901; Site vegetation has been dominated by Creosote bush since at least 1934

  12. Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics.

    PubMed

    Steinhäuser, K; Klöble, P; Kreis, N-N; Ritter, A; Friemel, A; Roth, S; Reichel, J M; Michaelis, J; Rieger, M A; Louwen, F; Oswald, F; Yuan, J

    2017-04-01

    Deregulation of mitotic microtubule (MT) dynamics results in defective spindle assembly and chromosome missegregation, leading further to chromosome instability, a hallmark of tumor cells. RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signaling pathway. Intriguingly, deregulated RITA is involved in primary hepatocellular carcinoma and other malignant entities. We were interested in the potential molecular mechanisms behind its involvement. We show here that RITA binds to tubulin and localizes to various mitotic MT structures. RITA coats MTs and affects their structures in vitro as well as in vivo. Tumor cell lines deficient of RITA display increased acetylated α-tubulin, enhanced MT stability and reduced MT dynamics, accompanied by multiple mitotic defects, including chromosome misalignment and segregation errors. Re-expression of wild-type RITA, but not RITA Δtub ineffectively binding to tubulin, restores the phenotypes, suggesting that the role of RITA in MT modulation is mediated via its interaction with tubulin. Mechanistically, RITA interacts with tubulin/histone deacetylase 6 (HDAC6) and its suppression decreases the binding of the deacetylase HDAC6 to tubulin/MTs. Furthermore, the mitotic defects and increased MT stability are also observed in RITA -/- mouse embryonic fibroblasts. RITA has thus a novel role in modulating MT dynamics and its deregulation results in erroneous chromosome segregation, one of the major reasons for chromosome instability in tumor cells.

  13. RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles.

    PubMed

    Pietkiewicz, Adrian L; Zhang, Yuqi; Rahimi, Marwa N; Stramandinoli, Michael; Teusner, Matthew; McAlpine, Shelli R

    2017-04-13

    The established cytotoxic agent RITA contains a thiophene-furan-thiophene backbone and two terminal alcohol groups. Herein we investigate the effect of using thiazoles as the backbone in RITA-like molecules and modifying the terminal groups of these trithiazoles, thereby generating 41 unique structures. Incorporating side chains with varied steric bulk allowed us to investigate how size and a stereocenter impacted biological activity. Subjecting compounds to growth inhibition assays on HCT-116 cells showed that the most potent compounds 7d , 7e , and 7h had GI 50 values of 4.4, 4.4, and 3.4 μM, respectively, versus RITA (GI 50 of 800 nM). Analysis of these compounds in apoptosis assays proved that 7d , 7e , and 7h were as effective as RITA at inducing apoptosis. Evaluating the impact of 7h on proteins targeted by RITA (p53, c-Myc, and Mcl-1) indicated that it acts via a different mechanism of action to that of RITA. RITA suppressed Mcl-1 protein via p53, whereas compound 7h suppressed Mcl-1 expression via an alternative mechanism independent of p53.

  14. AmeriFlux US-SRG Santa Rita Grassland

    DOE Data Explorer

    Scott, Russell [United States Department of Agriculture

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-SRG Santa Rita Grassland. Site Description - Semidesert C4 grassland, lies in Pasture 1 on the Santa Rita Experimental Range. This is the companion site for US-SRM, but has much less mesquite encroachment.

  15. Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless.

    PubMed

    Brockmann, Birgit; Mastel, Helena; Oswald, Franz; Maier, Dieter

    2014-12-01

    Notch signalling mediates intercellular communication, which is effected by the transcription factor CSL, an acronym for vertebrate CBF1/RBP-J, Drosophila Suppressor of Hairless [Su(H)] and C. elegans Lag1. Nuclear import of CBF1/RBP-J depends on co-activators and co-repressors, whereas the export relies on RITA. RITA is a tubulin and CBF1/RBP-J binding protein acting as a negative regulator of Notch signalling in vertebrates. RITA protein is highly conserved in eumatazoa, but no Drosophila homologue was yet identified. In this work, the activity of human RITA in the fly was addressed. To this end, we generated transgenic flies that allow a tissue specific induction of human RITA, which was demonstrated by Western blotting and in fly tissues. Unexpectedly, overexpression of RITA during fly development had little phenotypic consequences, even when overexpressed simultaneously with either Su(H) or the Notch antagonist Hairless. We demonstrate the in vivo binding of human RITA to Su(H) and to tubulin by co-immune precipitation. Moreover, RITA and tubulin co-localized to some degree in several Drosophila tissues. Overall our data show that human RITA, albeit binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly, suggesting that a nuclear export mechanism of Su(H), if existent in Drosophila, does not depend on RITA. © 2015 The Authors.

  16. Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin.

    PubMed

    Wiegering, Armin; Matthes, Niels; Mühling, Bettina; Koospal, Monika; Quenzer, Anne; Peter, Stephanie; Germer, Christoph-Thomas; Linnebacher, Michael; Otto, Christoph

    2017-04-01

    Colorectal carcinoma (CRC) is the most common cancer of the gastrointestinal tract with frequently dysregulated intracellular signaling pathways, including p53 signaling. The mainstay of chemotherapy treatment of CRC is 5-fluorouracil (5FU) and oxaliplatin. The two anticancer drugs mediate their therapeutic effect via DNA damage-triggered signaling. The small molecule reactivating p53 and inducing tumor apoptosis (RITA) is described as an activator of wild-type and reactivator of mutant p53 function, resulting in elevated levels of p53 protein, cell growth arrest, and cell death. Additionally, it has been shown that RITA can induce DNA damage signaling. It is expected that the therapeutic benefits of 5FU and oxaliplatin can be increased by enhancing DNA damage signaling pathways. Therefore, we highlighted the antiproliferative response of RITA alone and in combination with 5FU or oxaliplatin in human CRC cells. A panel of long-term established CRC cell lines (n=9) including p53 wild-type, p53 mutant, and p53 null and primary patient-derived, low-passage cell lines (n=5) with different p53 protein status were used for this study. A substantial number of CRC cells with pronounced sensitivity to RITA (IC 50 <3.0 μmol/l) were identified within established (4/9) and primary patient-derived (2/5) CRC cell lines harboring wild-type or mutant p53 protein. Sensitivity to RITA appeared independent of p53 status and was associated with an increase in antiproliferative response to 5FU and oxaliplatin, a transcriptional increase of p53 targets p21 and NOXA, and a decrease in MYC mRNA. The effect of RITA as an inducer of DNA damage was shown by a strong elevation of phosphorylated histone variant H2A.X, which was restricted to RITA-sensitive cells. Our data underline the primary effect of RITA, inducing DNA damage, and demonstrate the differential antiproliferative effect of RITA to CRC cells independent of p53 protein status. We found a substantial number of RITA-sensitive CRC

  17. Looking at the future with Rita.

    PubMed

    Bentivoglio, M

    2013-11-12

    This paper on Rita Levi-Montalcini (1909-2012), who received in 1986 the Nobel Prize in Physiology or Medicine for the discovery of nerve growth factor, focuses on aspects of her advocacy and her commitment to education in which she has been especially active in the last part of her long life. With passionate confidence on the capabilities of the aging brain (together with severe admonition against the pursuit of immortality), she encouraged contributions of senior citizens to the society. Always projected into the future, with enduring faith in the potential of young individuals, in education as a key to development, in the capabilities of women, in the importance of gender equality, Rita established in 2001 the Rita Levi-Montalcini Foundation for the education of African women. Her legacy on engagement for a better 'global village' should not be forgotten by the neuroscience community.

  18. Serous goblet cells: the protein secreting cells in the oral cavity of a catfish, Rita rita (Hamilton, 1822) (Bagridae, Siluriformes).

    PubMed

    Yashpal, Madhu; Mittal, Ajay Kumar

    2014-02-01

    Serous goblet cells in the oral epithelium of Rita rita are characterized by the presence of distinct eosinophilic granules occupying large parts of the cytoplasm. In R. rita, a range of histochemical results reveal that these cells are involved in proteinaceous secretions, and thus likely contribute to various functions analogous to those of mammalian saliva. The secretions of these cells have also been associated with specific functions and are discussed in relation to their physiological importance with special reference to their roles in lubrication, alteration in viscosity, various functions of mucus such as handling, maneuvering and driving of food items toward the esophagus, maintaining taste sensitivity and protection of the oral epithelium. In addition, the serous goblet cells may also be considered as the primary defensive cell of the oral epithelium of R. rita. The results significantly add to very limited set of literature on the serous goblet cells and provide noteworthy information on the mucous secretions in the oral cavity of fish. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. Retention of Displaced Students after Hurricanes Katrina and Rita

    ERIC Educational Resources Information Center

    Coco, Joshua Christian

    2017-01-01

    The purpose of the study was to investigate the strategies that university leaders implemented to improve retention of displaced students in the aftermaths of Hurricanes Katrina and Rita. The universities that participated in this study admitted displaced students after Hurricanes Katrina and Rita. This study utilized a qualitative…

  20. [RITA combined with temozolomide inhibits the proliferation of human glioblastoma U87 cells].

    PubMed

    He, Xiao-Yan; Feng, Xiao-Li; Song, Xin-Pei; Zeng, Huan-Chao; Cao, Zhong-Xu; Xiao, Wei-Wei; Zhang, Bao; Wu, Qing-Hua

    2016-10-20

    To observe the effect of RITA, a small molecule that targets p53, combined with temozolomide (TMZ) on proliferation, colony formation and apoptosis of human glioblastoma U87 cells and explore the underlying mechanism. Cultured U87 cells were treated with RITA (1, 5, 10, 20 µmol/L), TMZ, or RITA+TMZ (half dose) for 24, 48 or 72 h. MTS assay were used to detect the cell proliferation, and the cell proliferation rate and inhibitory rate were calculated. The effect of combined treatments was evaluated by the q value. The expressions of p53, p21 and other apoptosis-associated genes were detected by qRT-PCR and Western blotting; cell apoptosis was assayed using flow cytometry with Annexin V/PI double staining; colony formation of the cells was detected with crystal violet staining. MTS assay showed that RITA at the 4 doses more potently inhibited U87 cell viability than TMZ at 72 h (P=0.000) with inhibitory rates of 25.94%-41.38% and 3.84%-8.20%, respectively. RITA combined with TMZ caused a more significant inhibition of U87 cells (29.21%-52.11%) than RITA (P<0.01) and TMZ (P=0.000) alone. At the doses above 5 µmol/L, the combined treatments with RITA+TMZ for 48 h resulted in q values exceeding 1.2 and showed an obvious synergistic effect of the drugs. Both RITA and TMZ, especially the latter, significantly increased the expressions of p53, p21, puma, and other apoptosis-associated genes to accelerate apoptosis and inhibit the growth and colony formation of U87 cells, and the effect was more obvious with a combined treatment. RITA inhibits the growth of human glioblastoma cells and enhance their sensitivity to TMZ by up-regulating p53 expression, and when combined, RITA and TMZ show a synergistic effect to cause a stronger cell inhibition.

  1. RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.

    PubMed

    Gottlieb, Aline; Althoff, Kristina; Grunewald, Laura; Thor, Theresa; Odersky, Andrea; Schulte, Marc; Deubzer, Hedwig E; Heukamp, Lukas; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes H; Künkele, Annette

    2017-04-25

    Current therapy of medulloblastoma, the most common malignant brain tumor of childhood, achieves 40-70% survival. Secondary chemotherapy resistance contributes to treatment failure, where TP53 pathway dysfunction plays a key role. MDM2 interaction with TP53 leads to its degradation. Reactivating TP53 functionality using small-molecule inhibitors, such as RITA, to disrupt TP53-MDM2 binding may have therapeutic potential. We show here that RITA decreased viability of all 4 analyzed medulloblastoma cell lines, regardless of TP53 functional status. The decrease in cell viability was accompanied in 3 of the 4 medulloblastoma cell lines by accumulation of TP53 protein in the cells and increased CDKN1A expression. RITA treatment in mouse models inhibited medulloblastoma xenograft tumor growth. These data demonstrate that RITA treatment reduces medulloblastoma cell viability in both in vitro and in vivo models, and acts independently of cellular TP53 status, identifying RITA as a potential therapeutic agent to treat medulloblastoma.

  2. RITA displays anti-tumor activity in medulloblastomas independent of TP53 status

    PubMed Central

    Gottlieb, Aline; Althoff, Kristina; Grunewald, Laura; Thor, Theresa; Odersky, Andrea; Schulte, Marc; Deubzer, Hedwig E.; Heukamp, Lukas; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes H.; Künkele, Annette

    2017-01-01

    Current therapy of medulloblastoma, the most common malignant brain tumor of childhood, achieves 40–70% survival. Secondary chemotherapy resistance contributes to treatment failure, where TP53 pathway dysfunction plays a key role. MDM2 interaction with TP53 leads to its degradation. Reactivating TP53 functionality using small-molecule inhibitors, such as RITA, to disrupt TP53-MDM2 binding may have therapeutic potential. We show here that RITA decreased viability of all 4 analyzed medulloblastoma cell lines, regardless of TP53 functional status. The decrease in cell viability was accompanied in 3 of the 4 medulloblastoma cell lines by accumulation of TP53 protein in the cells and increased CDKN1A expression. RITA treatment in mouse models inhibited medulloblastoma xenograft tumor growth. These data demonstrate that RITA treatment reduces medulloblastoma cell viability in both in vitro and in vivo models, and acts independently of cellular TP53 status, identifying RITA as a potential therapeutic agent to treat medulloblastoma. PMID:28427187

  3. The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells.

    PubMed

    Chuang, Hui-Ching; Yang, Liang Peng; Fitzgerald, Alison L; Osman, Abdullah; Woo, Sang Hyeok; Myers, Jeffrey N; Skinner, Heath D

    2014-01-01

    TP53 is the most commonly mutated gene in head and neck cancer (HNSCC), with mutations being associated with resistance to conventional therapy. Restoring normal p53 function has previously been investigated via the use of RITA (reactivation of p53 and induction of tumor cell apoptosis), a small molecule that induces a conformational change in p53, leading to activation of its downstream targets. In the current study we found that RITA indeed exerts significant effects in HNSCC cells. However, in this model, we found that a significant outcome of RITA treatment was accelerated senescence. RITA-induced senescence in a variety of p53 backgrounds, including p53 null cells. Also, inhibition of p53 expression did not appear to significantly inhibit RITA-induced senescence. Thus, this phenomenon appears to be partially p53-independent. Additionally, RITA-induced senescence appears to be partially mediated by activation of the DNA damage response and SIRT1 (Silent information regulator T1) inhibition, with a synergistic effect seen by combining either ionizing radiation or SIRT1 inhibition with RITA treatment. These data point toward a novel mechanism of RITA function as well as hint to its possible therapeutic benefit in HNSCC.

  4. Simulations and experiments on RITA-2 at PSI

    NASA Astrophysics Data System (ADS)

    Klausen, S. N.; Lefmann, K.; McMorrow, D. F.; Altorfer, F.; Janssen, S.; Lüthy, M.

    The cold-neutron triple-axis spectrometer RITA-2 designed and built at Riso National Laboratory was installed at the neutron source SINQ at Paul Scherrer Institute in April/May 2001. In connection with the installation of RITA-2, computer simulations were performed using the neutron ray-tracing package McStas. The simulation results are compared to real experimental results obtained with a powder sample. Especially, the flux at the sample position and the resolution function of the spectrometer are investigated.

  5. Surface ultrastructure of the gill filaments and the secondary lamellae of the catfish, Rita rita, and the carp, Cirrhinus mrigala.

    PubMed

    Kumari, Usha; Mittal, Swati; Mittal, Ajay Kumar

    2012-04-01

    Surface ultrastructures of gill filaments and secondary lamellae of Rita rita and Cirrhinus mrigala, inhabiting different ecological habitat, were investigated to unravel adaptive modifications. R. rita is a sluggish, bottom dwelling carnivorous catfish, which inhabits regions of river with accumulations of dirty water. It retains its viability for long time if taken out of water. C. mrigala is an active bottom dwelling Indian major carp, which lives in relatively clean water and dies shortly after taken out of water. In R. rita, gill septa between gill filaments are reduced. Microridges on epithelial cells covering gill filaments are often continuous and arranged concentrically. Secondary lamellae are extensive. The epithelium appears corrugated, show irregular elevations and shallow depressions, and microridges on epithelial cells appear fragmented. In C. mrigala, in contrast, the gill septa are extensive. Microridges on epithelial cells covering gill filaments are fragmented. Secondary lamellae are less extensive. The epithelium appears smooth and microridges on epithelial cells are relatively inconspicuous. These differences have been considered adaptive modification in relation to habit and ecological niches inhabited by two fish species. Presence of mucous goblet cells on gill filaments is discussed in relation to their functions including precipitation of the sediments and preventing clogging of gill filaments. Infrequent mucous goblet cells in the epithelium of secondary lamellae in two fish species are considered an adaptation, minimizing thickness of the epithelium to reduce barrier between blood and water for favoring gasses exchange with increased efficiency. Copyright © 2011 Wiley-Liss, Inc.

  6. The p53-Reactivating Small Molecule RITA Induces Senescence in Head and Neck Cancer Cells

    PubMed Central

    Chuang, Hui-Ching; Yang, Liang Peng; Fitzgerald, Alison L.; Osman, Abdullah; Woo, Sang Hyeok; Myers, Jeffrey N.; Skinner, Heath D.

    2014-01-01

    TP53 is the most commonly mutated gene in head and neck cancer (HNSCC), with mutations being associated with resistance to conventional therapy. Restoring normal p53 function has previously been investigated via the use of RITA (reactivation of p53 and induction of tumor cell apoptosis), a small molecule that induces a conformational change in p53, leading to activation of its downstream targets. In the current study we found that RITA indeed exerts significant effects in HNSCC cells. However, in this model, we found that a significant outcome of RITA treatment was accelerated senescence. RITA-induced senescence in a variety of p53 backgrounds, including p53 null cells. Also, inhibition of p53 expression did not appear to significantly inhibit RITA-induced senescence. Thus, this phenomenon appears to be partially p53-independent. Additionally, RITA-induced senescence appears to be partially mediated by activation of the DNA damage response and SIRT1 (Silent information regulator T1) inhibition, with a synergistic effect seen by combining either ionizing radiation or SIRT1 inhibition with RITA treatment. These data point toward a novel mechanism of RITA function as well as hint to its possible therapeutic benefit in HNSCC. PMID:25119136

  7. Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA.

    PubMed

    Zhao, Carolyn Y; Grinkevich, Vera V; Nikulenkov, Fedor; Bao, Wenjie; Selivanova, Galina

    2010-05-01

    Expression of mutant p53 correlates with poor prognosis in many tumors, therefore strategies aimed at reactivation of mutant p53 are likely to provide important benefits for treatment of tumors that are resistant to chemotherapy and radiotherapy. We have previously identified and characterized a small molecule RITA which binds p53 and induces a conformational change which prevents the binding of p53 to several inhibitors, including its own destructor MDM2. In this way, RITA rescues the tumor suppression function of wild type p53. Here, we demonstrate that RITA suppressed the growth and induced apoptosis in human tumor cell lines of a diverse origin carrying mutant p53 proteins. RITA restored transcriptional transactivation and transrepression function of several hot spot p53 mutants. The ability of RITA to rescue the activity of different p53 mutants suggests its generic mechanism of action. Thus, RITA is a promising lead for the development of anti-cancer drugs that reactivate the tumor suppressor function of p53 in cancer cells irrespective whether they express mutant or wild type p53.

  8. RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.

    PubMed

    Wacker, Stephan Armin; Alvarado, Cristobal; von Wichert, Götz; Knippschild, Uwe; Wiedenmann, Jörg; Clauss, Karen; Nienhaus, Gerd Ulrich; Hameister, Horst; Baumann, Bernd; Borggrefe, Tilman; Knöchel, Walter; Oswald, Franz

    2011-01-05

    The evolutionarily conserved Notch signal transduction pathway regulates fundamental cellular processes during embryonic development and in the adult. Ligand binding induces presenilin-dependent cleavage of the receptor and a subsequent nuclear translocation of the Notch intracellular domain (NICD). In the nucleus, NICD binds to the recombination signal sequence-binding protein J (RBP-J)/CBF-1 transcription factor to induce expression of Notch target genes. Here, we report the identification and functional characterization of RBP-J interacting and tubulin associated (RITA) (C12ORF52) as a novel RBP-J/CBF-1-interacting protein. RITA is a highly conserved 36 kDa protein that, most interestingly, binds to tubulin in the cytoplasm and shuttles rapidly between cytoplasm and nucleus. This shuttling RITA exports RBP-J/CBF-1 from the nucleus. Functionally, we show that RITA can reverse a Notch-induced loss of primary neurogenesis in Xenopus laevis. Furthermore, RITA is able to downregulate Notch-mediated transcription. Thus, we propose that RITA acts as a negative modulator of the Notch signalling pathway, controlling the level of nuclear RBP-J/CBF-1, where its amounts are limiting.

  9. RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems.

    PubMed

    Shin, Daiha; Kim, Eun Hye; Lee, Jaewang; Roh, Jong-Lyel

    2017-10-01

    Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53-MDM2 interaction, thereby reactivating p53 in tumors. RITA can induce exclusive apoptosis in cancer cells independently of the p53 pathway; however, the resistance of cancer cells remains a major drawback. Here, we found a novel resistance mechanism of RITA treatment and an effective combined treatment to overcome RITA resistance in head and neck cancer (HNC) cells. The effects of RITA and 3-methyladenine (3-MA) were tested in different HNC cell lines, including cisplatin-resistant and acquired RITA-resistant HNC cells. The effects of each drug alone and in combination were assessed by measuring cell viability, apoptosis, cell cycle, glutathione, reactive oxygen species, protein expression, genetic inhibition of p62 and Nrf2, and a mouse xenograft model of cisplatin-resistant HNC. RITA induced apoptosis of HNC cells at different levels without significantly inhibiting normal cell viability. Following RITA treatment, RITA-resistant HNC cells exhibited a sustained expression of other autophagy-related proteins, overexpressed p62, and displayed activation of the Keap1-Nrf2 antioxidant pathway. The autophagy inhibitor 3-MA sensitized resistant HNC cells to RITA treatment via the dual inhibition of molecules related to the autophagy and antioxidant systems. Silencing of the p62 gene augmented the combined effects. The effective antitumor activity of RITA plus 3-MA was also confirmed in vivo in mouse xenograft models transplanted with resistant HNC cells, showing increased oxidative stress and DNA damage. The results indicate that RITA plus 3-MA can help overcome RITA resistance in HNC cells. This study revealed a novel RITA resistant mechanism associated with the sustained induction of autophagy, p62 overexpression, and Keap1-Nrf2 antioxidant system activation. The combined treatment of RITA with the autophagy inhibitor 3-methyladenine overcomes RITA resistance via dual

  10. Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy.

    PubMed

    Rödel, Franz; Steinhäuser, Kerstin; Kreis, Nina-Naomi; Friemel, Alexandra; Martin, Daniel; Wieland, Ulrike; Rave-Fränk, Margret; Balermpas, Panagiotis; Fokas, Emmanouil; Louwen, Frank; Rödel, Claus; Yuan, Juping

    2018-02-01

    RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signalling pathway and its deregulation is involved in the pathogenesis of several tumour entities. RITA's impact on the response of anal squamous cell carcinoma (SCC) to anticancer treatment, however, remains elusive. In our retrospective study immunohistochemical evaluation of RITA was performed on 140 pre-treatment specimens and was correlated with clinical and histopathologic characteristics and clinical endpoints cumulative incidence of local control (LC), distant recurrence (DC), disease-free survival (DFS) and overall survival (OS). We observed significant inverse correlations between RITA expression and tumour grading, the levels of HPV-16 virus DNA load, CD8 (+) tumour infiltrating lymphocytes and programmed death protein (PD-1) immunostaining. In univariate analyses, elevated levels of RITA expression were predictive for decreased local control (p = 0.001), decreased distant control (p = 0.040), decreased disease free survival (p = 0.001) and overall survival (p < 0.0001), whereas in multivariate analyses RITA expression remained significant for decreased local control (p = 0.009), disease free survival (p = 0.032) and overall survival (p = 0.012). These data indicate that elevated levels of pretreatment RITA expression are correlated with unfavourable clinical outcome in anal carcinoma treated with concomitant chemoradiotherapy. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Pilot study of radiofrequency interstitial tumor ablation (RITA) for the treatment of radio-recurrent prostate cancer.

    PubMed

    Shariat, Shahrokh F; Raptidis, Grigorios; Masatoschi, Muramoto; Bergamaschi, Franco; Slawin, Kevin M

    2005-11-01

    To prospectively evaluate the feasibility, safety, morbidity, and preliminary efficacy of radiofrequency interstitial tumor ablation (RITA) for the focal treatment of patients with local prostate cancer recurrence. Eleven patients with biopsy-proven, hormone-naïve, clinically localized prostate cancer were enrolled in a prospective phase I/II trial. Eight patients had failed prior radiation therapy and three were not candidates for curative primary therapy (median Gleason score 7 and 6, respectively). Median follow-up was 20 months. All patients were treated with RITA in an office setting, under intravenous sedation and were discharged after the procedure. Radiofrequency energy was applied via needles placed transperineally under transrectal ultrasound guidance. The placement of 1/4 lesions was aborted in two patients due to increasing rectal temperature. Complications included transient macrohematuria (19%), bladder spasms (9%), and dysuria (9%). Serum PSA levels decreased after RITA >50% in 90% of patients, > 70% in 72% of patients, and > 80% in 46% of patients. The mean PSA doubling time after RITA was slower than that before RITA (37 +/- 22 months vs. 14 +/- 13 months, P = 0.008). At 12 months after RITA, 50% of patients with sufficient follow-up had no residual cancer on repeat systematic 12-core biopsy cores and 67% were cancer-free in biopsy cores sampled from the RITA-treated areas. RITA treatment is a minimal invasive, rapid, user-friendly, office-based procedure that is well tolerated. Focal ablation with RITA results in effective local disease control in patients with non-metastatic prostate cancer recurrence. Larger, prospective, multicenter clinical studies are needed to confirm these findings. Copyright 2005 Wiley-Liss, Inc

  12. A century of vegetation change on the Santa Rita Experimental Range

    Treesearch

    Mitchel P. McClaran

    2003-01-01

    We know more about vegetation change on the Santa Rita Experimental Range since 1903 than is known about any other 20,000-ha area in the world. This record is only possible because important techniques of measuring vegetation changes were developed on the Santa Rita, such as repeat photography and the line intercept transect method, and because they were applied often...

  13. RITA enhances chemosensivity of pre-B ALL cells to doxorubicin by inducing p53-dependent apoptosis.

    PubMed

    Kazemi, Ahmad; Safa, Majid; Shahbazi, Atefeh

    2011-07-01

    The use of low-molecular-weight, non-peptidic molecules that disrupt the interaction between the p53 tumor suppressor and its negative regulator MDM2 has provided a promising alternative for the treatment of different types of cancer. Here, we used small-molecule reactivation of p53 and induction of tumor cell apoptosis (RITA) to sensitize leukemic NALM-6 cells to doxorubicin by upregulating p53 protein. RITA alone effectively inhibited NALM-6 cells viability in dose-dependent manner as measured by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide assay and induced apoptosis as evaluated by flow cytometry, whereas RITA in combination with doxorubicin enhanced NALM-6 cells to doxorubicin-sensitivity and promoted doxorubicin induced apoptosis. Levels of p53 protein and its proapoptotic target genes, quantified by western blot and real-time PCR respectively, showed that expression of p53 was significantly increased after RITA treatment. Using p53 inhibitors PFT-alpha and PFT-mu it was shown that p53-mediated apoptosis induced by RITA can be regulated by both p53-transcription-dependent and -independent pathways. Moreover, RITA-induced apoptosis was accompanied by the activation of caspase-3 and PARP cleavage. Therefore, exploiting synergistic effects between RITA and chemotherapeutics might be an effective clinical strategy for leukemia chemotherapy.

  14. The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer.

    PubMed

    Roh, Jong-Lyel; Ko, Jung Ho; Moon, Soo Jin; Ryu, Chang Hwan; Choi, Jun Young; Koch, Wayne M

    2012-12-01

    We evaluated whether the restoration of p53 function by the p53-reactivating small molecule RITA (reactivation of p53 and induction of tumor cell apoptosis enhances cisplatin-induced cytotoxicity and apoptosis in head-and-neck cancer (HNC). RITA induced prominent accumulation and reactivation of p53 in a wild-type TP53-bearing HNC cell line. RITA showed maximal growth suppression in tumor cells showing MDM2-dependent p53 degradation. RITA promoted apoptosis in association with upregulation of p21, BAX, and cleaved caspase-3; notably, the apoptotic response was blocked by pifithrin-α, demonstrating its p53 dependence. With increasing concentrations, RITA strongly induced apoptosis rather than G2-phase arrest. In combination therapy, RITA enhanced cisplatin-induced growth inhibition and apoptosis of HNC cells invitro and in vivo. Our data suggest that the restoration of p53 tumor-suppressive function by RITA enhances the cytotoxicity and apoptosis of cisplatin, an action that may offer an attractive strategy for treating HNC. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  15. Spectral reflectance and soil morphology characteristics of Santa Rita Experimental Range soils

    Treesearch

    A. Karim Batchily; Donald F. Post; R. B. Bryant; Donald J. Breckenfeld

    2003-01-01

    The Santa Rita Experimental Range (SRER) soils are mostly transported alluvial sediments that occur on the piedmont slope flanking the Santa Rita Mountains in Arizona. The major geomorphic land forms are alluvial fans or fan terraces, but there are also areas of residual soils formed on granite and limestone bedrock, basin floor, stream terraces, and flood plains. The...

  16. Ambient Assisted Living and ageing: preliminary results of RITA project.

    PubMed

    Aquilano, Michela; Cavallo, Filippo; Bonaccorsi, Manuele; Esposito, Raffaele; Rovini, Erika; Filippi, Massimo; Esposito, Dario; Dario, Paolo; Carrozza, Maria Chiara

    2012-01-01

    The ageing of population is a social phenomenon that most of worldwide countries are facing. They are, and will be even more in the future, indeed trying to find solutions for improving quality of life of their elderly citizens. The project RITA wants to demonstrate that an update of the current socio-medical services with an Ambient Assisted Living (AAL) approach could improve the service efficiency and the quality of life of both elderly and caregiver. This paper presents the preliminary results obtained in RITA.

  17. Conversacion sobre "Tres tristes tigres". Una entrevista de Rita Guibert (A Conversation about "Three Sad Tigers". An Interview with Rita Guibert)

    ERIC Educational Resources Information Center

    Cabrera Infante, Guillermo

    1971-01-01

    Interview took place in London, England, on October 5, 1970 between Cuban writer Guillermo Cabrera Infante and journalist Rita Guibert. Special issue dedicated to contemporary Spanish American literature. (DS)

  18. AmeriFlux US-SRM Santa Rita Mesquite

    DOE Data Explorer

    Scott, Russell [United States Department of Agriculture

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-SRM Santa Rita Mesquite. Site Description - Semidesert grassland encroached by mesquite (Prosopis velutina) trees. Please see Scott et al. 2009 JGR-Biogeo, 114, G04004

  19. Reflection on Lessons Learned: An Analysis of the Adverse Outcomes Observed During the Hurricane Rita Evacuation.

    PubMed

    Baker, Karen

    2018-02-01

    In September 2005, nearly 3.7 million people evacuated the Texas coastline in advance of Hurricane Rita's landfall, making the event the largest emergency evacuation in US history. The Rita evacuation underscored the importance of planning for domestic mass-evacuation events, as the evacuation itself led to over 100 of the at least 119 deaths attributed to the storm. In the days preceding Rita's landfall, several cascading, interrelated circumstances precipitated such adverse outcomes. This article explores the series of events leading up to the evacuation's poor outcomes, the response following Rita to amend evacuation plans, and how Texas successfully implemented these changes during later storms to achieve better outcomes. (Disaster Med Public Health Preparedness. 2018;12:115-120).

  20. IGF-1R/MDM2 relationship confers enhanced sensitivity to RITA in Ewing sarcoma cells.

    PubMed

    Di Conza, Giusy; Buttarelli, Marianna; Monti, Olimpia; Pellegrino, Marsha; Mancini, Francesca; Pontecorvi, Alfredo; Scotlandi, Katia; Moretti, Fabiola

    2012-06-01

    Ewing sarcoma is one of the most frequent bone cancers in adolescence. Although multidisciplinary therapy has improved the survival rate for localized tumors, a critical step is the development of new drugs to improve the long-term outcome of recurrent and metastatic disease and to reduce side effects of conventional therapy. Here, we show that the small molecule reactivation of p53 and induction of tumor cell apoptosis (RITA, NSC652287) is highly effective in reducing growth and tumorigenic potential of Ewing sarcoma cell lines. These effects occur both in the presence of wt-p53 as well as of mutant or truncated forms of p53, or in its absence, suggesting the presence of additional targets in this tumor histotype. Further experiments provided evidence that RITA modulates an important oncogenic mark of these cell lines, insulin-like growth factor receptor 1 (IGF-1R). Particularly, RITA causes downregulation of IGF-1R protein levels. MDM2 degradative activity is involved in this phenomenon. Indeed, inhibition of MDM2 function by genetic or pharmacologic approaches reduces RITA sensitivity of Ewing sarcoma cell lines. Overall, these data suggest that in the cell context of Ewing sarcoma, RITA may adopt additional mechanism of action besides targeting p53, expanding its field of application. Noteworthy, these results envisage the promising utilization of RITA or its derivative as a potential treatment for Ewing sarcomas. ©2012 AACR

  1. Hurricane Rita TrackRadar Image with Topographic Overlay

    NASA Image and Video Library

    2005-09-22

    The Gulf Coast from the Mississippi Delta through the Texas coast is shown in this satellite image from NASA Terra spacecraft, and the predicted storm track for Hurricane Rita acquired in February, 2000.

  2. NASA Data Helps Track Heat Potential Fueling Rita

    NASA Image and Video Library

    2005-09-26

    Tropical Cyclone Heat Potential TCHP field in the Gulf of Mexico during September 22, 2005. The path of Hurricane Rita is indicated with circles spaced every 3 hours with their size and color representing intensity see legend.

  3. Satellite Altimetry Outreach During Hurricane Rita: Lessons Learned

    NASA Astrophysics Data System (ADS)

    Leben, R.; Born, G. H.; Srinivasan, M.

    2006-07-01

    The 2005 hurricane season was th e most costly on record with estimated d amages in th e U.S. of over 100 billion. What may hav e been lost in the signif icant after math of these storms is the pr imary role th at Gulf of Mexico oceanography played in this very active hurricane season. The four most destructive storms - Dennis (1.84 B), Katrin a (80B), Rita (9.4B) , and Wilma ($14.4 B) - all interacted w ith deep warm ocean currents in th e Gulf contributing to the intensity of these storms and their destructive po ten tial. In the aftermath of Hurrican e K atr ina and during Hurricane Rita we made a concer ted effort to tell this story through satellite altimetry ou treach activ ities at the Un iversity of Colorado, Boulder .

  4. Land Area Change and Fractional Water Maps in the Chenier Plain, Louisiana, following Hurricane Rita (2005)

    USGS Publications Warehouse

    Palaseanu-Lovejoy, Monica; Kranenburg, Christine J.; Brock, John C.

    2010-01-01

    In this study, we estimated the changes in land and water coverage of a 1,961-square-kilometer (km2) area in Louisiana's Chenier Plain. The study area is roughly centered on the Sabine National Wildlife Refuge, which was impacted by Hurricane Rita on September 24, 2005. The objective of this study is twofold: (1) to provide pre- and post-Hurricane Rita moderate-resolution (30-meter (m)) fractional water maps based upon multiple source images, and (2) to quantify land and water coverage changes due to Hurricane Rita.

  5. Positional stabilization of communications satellites - The RITA ion propulsion system is ready for commercial use

    NASA Astrophysics Data System (ADS)

    The radiofrequency ion thruster assembly (RITA) intended for service aboard the new Artemis communications satellite will operate for three hours twice a day, in order to furnish orbital position adjustments that keep antennas accurately pointed toward the earth. These engines are, despite such frequent and sustained use, projected to eject no more than 30 kG of Xe over the course of a decade. RITA operation is also extremely reliable and, due to its very low propellant consumption, is the basis of a long satellite service life. RITA will be among the 15 experiments that are to be performed by ESA's Eureca research satellite.

  6. Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma.

    PubMed

    Saha, Manujendra N; Jiang, Hua; Yang, Yijun; Zhu, Xiaoyun; Wang, Xiaoming; Schimmer, Aaron D; Qiu, Lugui; Chang, Hong

    2012-01-01

    The low frequency of p53 alterations e.g., mutations/deletions (∼10%) in multiple myeloma (MM) makes this tumor type an ideal candidate for p53-targeted therapies. RITA is a small molecule which can induce apoptosis in tumor cells by activating the p53 pathway. We previously showed that RITA strongly activates p53 while selectively inhibiting growth of MM cells without inducing genotoxicity, indicating its potential as a drug lead for p53-targeted therapy in MM. However, the molecular mechanisms underlying the pro-apoptotic effect of RITA are largely undefined. Gene expression analysis by microarray identified a significant number of differentially expressed genes associated with stress response including c-Jun N-terminal kinase (JNK) signaling pathway. By Western blot analysis we further confirmed that RITA induced activation of p53 in conjunction with up-regulation of phosphorylated ASK-1, MKK-4 and c-Jun. These results suggest that RITA induced the activation of JNK signaling. Chromatin immunoprecipitation (ChIP) analysis showed that activated c-Jun binds to the activator protein-1 (AP-1) binding site of the p53 promoter region. Disruption of the JNK signal pathway by small interfering RNA (siRNA) against JNK or JNK specific inhibitor, SP-600125 inhibited the activation of p53 and attenuated apoptosis induced by RITA in myeloma cells carrying wild type p53. On the other hand, p53 transcriptional inhibitor, PFT-α or p53 siRNA not only inhibited the activation of p53 transcriptional targets but also blocked the activation of c-Jun suggesting the presence of a positive feedback loop between p53 and JNK. In addition, RITA in combination with dexamethasone, known as a JNK activator, displays synergistic cytotoxic responses in MM cell lines and patient samples. Our study unveils a previously undescribed mechanism of RITA-induced p53-mediated apoptosis through JNK signaling pathway and provides the rationale for combination of p53 activating drugs with JNK

  7. Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma

    PubMed Central

    Saha, Manujendra N.; Jiang, Hua; Yang, Yijun; Zhu, Xiaoyun; Wang, Xiaoming; Schimmer, Aaron D.; Qiu, Lugui; Chang, Hong

    2012-01-01

    The low frequency of p53 alterations e.g., mutations/deletions (∼10%) in multiple myeloma (MM) makes this tumor type an ideal candidate for p53-targeted therapies. RITA is a small molecule which can induce apoptosis in tumor cells by activating the p53 pathway. We previously showed that RITA strongly activates p53 while selectively inhibiting growth of MM cells without inducing genotoxicity, indicating its potential as a drug lead for p53-targeted therapy in MM. However, the molecular mechanisms underlying the pro-apoptotic effect of RITA are largely undefined. Gene expression analysis by microarray identified a significant number of differentially expressed genes associated with stress response including c-Jun N-terminal kinase (JNK) signaling pathway. By Western blot analysis we further confirmed that RITA induced activation of p53 in conjunction with up-regulation of phosphorylated ASK-1, MKK-4 and c-Jun. These results suggest that RITA induced the activation of JNK signaling. Chromatin immunoprecipitation (ChIP) analysis showed that activated c-Jun binds to the activator protein-1 (AP-1) binding site of the p53 promoter region. Disruption of the JNK signal pathway by small interfering RNA (siRNA) against JNK or JNK specific inhibitor, SP-600125 inhibited the activation of p53 and attenuated apoptosis induced by RITA in myeloma cells carrying wild type p53. On the other hand, p53 transcriptional inhibitor, PFT-α or p53 siRNA not only inhibited the activation of p53 transcriptional targets but also blocked the activation of c-Jun suggesting the presence of a positive feedback loop between p53 and JNK. In addition, RITA in combination with dexamethasone, known as a JNK activator, displays synergistic cytotoxic responses in MM cell lines and patient samples. Our study unveils a previously undescribed mechanism of RITA-induced p53-mediated apoptosis through JNK signaling pathway and provides the rationale for combination of p53 activating drugs with JNK

  8. Upper Ocean Response to Hurricanes Katrina and Rita (2005) from Multi-sensor Satellites

    NASA Astrophysics Data System (ADS)

    Gierach, M. M.; Bulusu, S.

    2006-12-01

    Analysis of satellite observations and model simulations of the mixed layer provided an opportunity to assess the biological and physical effects of hurricanes Katrina and Rita (2005) in the Gulf of Mexico. Oceanic cyclonic circulation was intensified by the hurricanes' wind field, maximizing upwelling, surface cooling, and deepening the mixed layer. Two areas of maximum surface chlorophyll-a concentration and sea surface cooling were detected with peak intensities ranging from 2-3 mg m-3 and 4-6°C, along the tracks of Katrina and Rita. The temperature of the mixed layer cooled approximately 2°C and the depth of the mixed layer deepened by approximately 33-52 m. The forced deepening of the mixed layer injected nutrients into the euphotic zone, generating phytoplankton blooms 3-5 days after the passage of Katrina and Rita (2005).

  9. Combined VLF and VHF lightning observations of Hurricane Rita landfall

    NASA Astrophysics Data System (ADS)

    Henderson, B. G.; Suszcynsky, D. M.; Wiens, K. C.; Hamlin, T.; Jeffery, C. A.; Orville, R. E.

    2009-12-01

    Hurricane Rita displayed abundant lightning in its northern eyewall as it made landfall at 0740 UTC 24 Sep 2005 near the Texas/Louisiana border. For this work, we combined VHF and VLF lightning data from Hurricane Rita, along with radar observations from Gulf Coast WSR-88D stations, for the purpose of demonstrating the combined utility of these two spectral regions for hurricane lightning monitoring. Lightning is a direct consequence of the electrification and breakdown processes that take place during the convective stages of thunderstorm development. As Rita approached the Gulf coast, the VHF lightning emissions were distinctly periodic with a period of 1.5 to 2 hours, which is consistent with the rotational period of hurricanes. VLF lightning emissions, measured by LASA and NLDN, were present in some of these VHF bursts but not all of them. At landfall, there was a significant increase in lightning emissions, accompanied by a significant convective surge observed in radar. Furthermore, VLF and VHF lightning source heights clearly increase as a function of time. The evolution of the IC/CG ratio is consistent with that seen in thunderstorms, showing a dominance of IC activity during storm development, followed by an increase in CG activity at the storm’s peak. The periodic VHF lightning events are correlated with increases in convective growth (quantified by the volume of radar echo >40 dB) above 7 km altitude. VLF can discriminate between lightning types, and in the LASA data, Rita landfall lightning activity was dominated by Narrow Bi-polar Events (NBEs)—high-energy, high-altitude, compact intra-cloud discharges. The opportunity to locate NBE lightning sources in altitude may be particularly useful in quantifying the vertical extent (strength) of the convective development and in possibly deducing vertical charge distributions.

  10. Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.

    PubMed

    Tabaja, Nassif; Yuan, Zhenyu; Oswald, Franz; Kovall, Rhett A

    2017-06-23

    The Notch pathway is a cell-to-cell signaling mechanism that is essential for tissue development and maintenance, and aberrant Notch signaling has been implicated in various cancers, congenital defects, and cardiovascular diseases. Notch signaling activates the expression of target genes, which are regulated by the transcription factor CSL (CBF1/RBP-J, Su(H), Lag-1). CSL interacts with both transcriptional corepressor and coactivator proteins, functioning as both a repressor and activator, respectively. Although Notch activation complexes are relatively well understood at the structural level, less is known about how CSL interacts with corepressors. Recently, a new RBP-J (mammalian CSL ortholog)-interacting protein termed RITA has been identified and shown to export RBP-J out of the nucleus, thereby leading to the down-regulation of Notch target gene expression. However, the molecular details of RBP-J/RITA interactions are unclear. Here, using a combination of biochemical/cellular, structural, and biophysical techniques, we demonstrate that endogenous RBP-J and RITA proteins interact in cells, map the binding regions necessary for RBP-J·RITA complex formation, and determine the X-ray structure of the RBP-J·RITA complex bound to DNA. To validate the structure and glean more insights into function, we tested structure-based RBP-J and RITA mutants with biochemical/cellular assays and isothermal titration calorimetry. Whereas our structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J. Taken together, these results provide molecular insights into the mechanism of RITA-mediated regulation of Notch signaling, contributing to our understanding of how CSL functions as a transcriptional repressor of Notch target genes. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  11. "I'm a Cansino": Transformation, Ethnicity, and Authenticity in the Construction of Rita Hayworth, American Love Goddess.

    ERIC Educational Resources Information Center

    McLean, Adrienne L.

    1993-01-01

    Examines how and why Margarita Carmen Cansino became Rita Hayworth. Challenges widely held scholarly assumptions about how the discourse contemporary to Rita Hayworth and her films portrayed and promulgated her transformation, particularly with reference to her ethnicity. (RS)

  12. 44 CFR 206.209 - Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major disaster declarations DR-1603, DR... determinations related to Hurricanes Katrina and Rita (Major disaster declarations DR-1603, DR-1604, DR-1605, DR...

  13. 44 CFR 206.209 - Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major disaster declarations DR-1603, DR... determinations related to Hurricanes Katrina and Rita (Major disaster declarations DR-1603, DR-1604, DR-1605, DR...

  14. 44 CFR 206.209 - Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major disaster declarations DR-1603, DR... determinations related to Hurricanes Katrina and Rita (Major disaster declarations DR-1603, DR-1604, DR-1605, DR...

  15. 44 CFR 206.209 - Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major disaster declarations DR-1603, DR... determinations related to Hurricanes Katrina and Rita (Major disaster declarations DR-1603, DR-1604, DR-1605, DR...

  16. How Schools Responded to Student Mental Health Needs Following Hurricanes Katrina and Rita. Fact Sheet

    ERIC Educational Resources Information Center

    RAND Corporation, 2007

    2007-01-01

    This fact sheet summarizes a study that examined how schools in the U.S. Gulf Coast region perceived the mental health needs of students after Hurricanes Katrina and Rita and how schools responded. According to the report, despite strong initial efforts to support the mental health needs of students displaced by Hurricanes Katrina and Rita, many…

  17. RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38

    PubMed Central

    Weilbacher, A; Gutekunst, M; Oren, M; Aulitzky, W E; van der Kuip, H

    2014-01-01

    Significant advances have been made in the development of small molecules blocking the p53/MDM2 interaction. The Mdm2 inhibitor Nutlin-3 is restricted to tumors carrying wtp53. In contrast, RITA, a compound that binds p53, has recently been shown also to restore transcriptional functions of mtp53. As more than 50% of solid tumors carry p53 mutations, RITA promises to be a more effective therapeutic strategy than Nutlin-3. We investigated effects of RITA on apoptosis, cell cycle and induction of 45 p53 target genes in a panel of 14 cell lines from different tumor entities with different p53 status as well as primary lymphocytes and fibroblasts. Nine cell strains expressed wtp53, four harbored mtp53, and three were characterized by the loss of p53 protein. A significant induction of cell death upon RITA was observed in 7 of 16 cell lines. The nonmalignant cells in our panel were substantially less sensitive. We found that in contrast to Nultin-3, RITA is capable to induce cell death not only in tumor cells harboring wtp53 and mtp53 but also in p53-null cells. Importantly, whereas p53 has a central role for RITA-mediated effects in wtp53 cells, neither p53 nor p63 or p73 were essential for the RITA response in mtp53 or p53-null cells in our panel demonstrating that besides the known p53-dependent action of RITA in wtp53 cells, RITA can induce cell death also independently of p53 in cells harboring defective p53. We identified an important role of both p38 and JNK/SAPK for sensitivity to RITA in these cells leading to a typical caspase- and BAX/BAK-dependent mitochondrial apoptosis. In conclusion, our data demonstrate that RITA can induce apoptosis through p38 and JNK/SAPK not only in tumor cells harboring wtp53 and mtp53 but also in p53-null cells, making RITA an interesting tumor-selective drug. PMID:25010984

  18. RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38.

    PubMed

    Weilbacher, A; Gutekunst, M; Oren, M; Aulitzky, W E; van der Kuip, H

    2014-07-10

    Significant advances have been made in the development of small molecules blocking the p53/MDM2 interaction. The Mdm2 inhibitor Nutlin-3 is restricted to tumors carrying wtp53. In contrast, RITA, a compound that binds p53, has recently been shown also to restore transcriptional functions of mtp53. As more than 50% of solid tumors carry p53 mutations, RITA promises to be a more effective therapeutic strategy than Nutlin-3. We investigated effects of RITA on apoptosis, cell cycle and induction of 45 p53 target genes in a panel of 14 cell lines from different tumor entities with different p53 status as well as primary lymphocytes and fibroblasts. Nine cell strains expressed wtp53, four harbored mtp53, and three were characterized by the loss of p53 protein. A significant induction of cell death upon RITA was observed in 7 of 16 cell lines. The nonmalignant cells in our panel were substantially less sensitive. We found that in contrast to Nultin-3, RITA is capable to induce cell death not only in tumor cells harboring wtp53 and mtp53 but also in p53-null cells. Importantly, whereas p53 has a central role for RITA-mediated effects in wtp53 cells, neither p53 nor p63 or p73 were essential for the RITA response in mtp53 or p53-null cells in our panel demonstrating that besides the known p53-dependent action of RITA in wtp53 cells, RITA can induce cell death also independently of p53 in cells harboring defective p53. We identified an important role of both p38 and JNK/SAPK for sensitivity to RITA in these cells leading to a typical caspase- and BAX/BAK-dependent mitochondrial apoptosis. In conclusion, our data demonstrate that RITA can induce apoptosis through p38 and JNK/SAPK not only in tumor cells harboring wtp53 and mtp53 but also in p53-null cells, making RITA an interesting tumor-selective drug.

  19. Children and Trauma: A Post-Katrina and Rita Response

    ERIC Educational Resources Information Center

    Hebert, Barbara B.; Ballard, Mary B.

    2007-01-01

    Many children have struggled to cope with the traumatic experiences brought about by hurricanes Katrina and Rita. This article recounts how the authors intervened in the lives of children and families after the storms. (Contains 3 figures.)

  20. Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents

    PubMed Central

    Michaelis, M; Rothweiler, F; Agha, B; Barth, S; Voges, Y; Löschmann, N; von Deimling, A; Breitling, R; Wilhelm Doerr, H; Rödel, F; Speidel, D; Cinatl, J

    2012-01-01

    Adaptation of wild-type p53 expressing UKF-NB-3 cancer cells to the murine double minute 2 inhibitor nutlin-3 causes de novo p53 mutations at high frequency (13/20) and multi-drug resistance. Here, we show that the same cells respond very differently when adapted to RITA, a drug that, like nutlin-3, also disrupts the p53/Mdm2 interaction. All of the 11 UKF-NB-3 sub-lines adapted to RITA that we established retained functional wild-type p53 although RITA induced a substantial p53 response. Moreover, all RITA-adapted cell lines remained sensitive to nutlin-3, whereas only five out of 10 nutlin-3-adapted cell lines retained their sensitivity to RITA. In addition, repeated adaptation of the RITA-adapted sub-line UKF-NB-3rRITA10 μM to nutlin-3 resulted in p53 mutations. The RITA-adapted UKF-NB-3 sub-lines displayed no or less pronounced resistance to vincristine, cisplatin, and irradiation than nutlin-3-adapted UKF-NB-3 sub-lines. Furthermore, adaptation to RITA was associated with fewer changes at the expression level of antiapoptotic factors than observed with adaptation to nutlin-3. Transcriptomic analyses indicated the RITA-adapted sub-lines to be more similar at the gene expression level to the parental UKF-NB-3 cells than nutlin-3-adapted UKF-NB-3 sub-lines, which correlates with the observed chemotherapy and irradiation sensitivity phenotypes. In conclusion, RITA-adapted cells retain functional p53, remain sensitive to nutlin-3, and display a less pronounced resistance phenotype than nutlin-3-adapted cells. PMID:22476102

  1. Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents.

    PubMed

    Michaelis, M; Rothweiler, F; Agha, B; Barth, S; Voges, Y; Löschmann, N; von Deimling, A; Breitling, R; Doerr, H Wilhelm; Rödel, F; Speidel, D; Cinatl, J

    2012-04-05

    Adaptation of wild-type p53 expressing UKF-NB-3 cancer cells to the murine double minute 2 inhibitor nutlin-3 causes de novo p53 mutations at high frequency (13/20) and multi-drug resistance. Here, we show that the same cells respond very differently when adapted to RITA, a drug that, like nutlin-3, also disrupts the p53/Mdm2 interaction. All of the 11 UKF-NB-3 sub-lines adapted to RITA that we established retained functional wild-type p53 although RITA induced a substantial p53 response. Moreover, all RITA-adapted cell lines remained sensitive to nutlin-3, whereas only five out of 10 nutlin-3-adapted cell lines retained their sensitivity to RITA. In addition, repeated adaptation of the RITA-adapted sub-line UKF-NB-3(r)RITA(10 μM) to nutlin-3 resulted in p53 mutations. The RITA-adapted UKF-NB-3 sub-lines displayed no or less pronounced resistance to vincristine, cisplatin, and irradiation than nutlin-3-adapted UKF-NB-3 sub-lines. Furthermore, adaptation to RITA was associated with fewer changes at the expression level of antiapoptotic factors than observed with adaptation to nutlin-3. Transcriptomic analyses indicated the RITA-adapted sub-lines to be more similar at the gene expression level to the parental UKF-NB-3 cells than nutlin-3-adapted UKF-NB-3 sub-lines, which correlates with the observed chemotherapy and irradiation sensitivity phenotypes. In conclusion, RITA-adapted cells retain functional p53, remain sensitive to nutlin-3, and display a less pronounced resistance phenotype than nutlin-3-adapted cells.

  2. The Recent Infection Testing Algorithm (RITA) in clinical practice: a survey of HIV clinicians in England and Northern Ireland.

    PubMed

    Garrett, Nj; Lattimore, S; Gilbart, Vl; Aghaizu, A; Mensah, G; Tosswill, J; Murphy, G; Delpech, V

    2012-08-01

    In order to estimate HIV incidence among high-risk groups, in January 2009 the Health Protection Agency introduced the Recent Infection Testing Algorithm (RITA) in England and Northern Ireland (E&NI), currently the only regions to inform patients of RITA results. This survey of HIV specialists aimed to investigate the role of RITA in patient management and explore clinicians' views on its role in clinical practice and during partner notification. An online questionnaire was distributed to HIV specialists via the British HIV Association membership email list in February 2011. Forty-two HIV specialists from 32 HIV centres responded to the survey among 90 centres enrolled in the programme (response rate 36%). Testing for recent infection was considered standard of care by 83% of respondents, 80% felt confident in interpreting results and 92% discussed results with patients, particularly in the context of a possible HIV seroconversion illness (96%) or when deciding when to start antiretroviral therapy (70%). A third (36%) of specialists were initially concerned that RITA results may cause additional anxiety among patients; however, no adverse events were reported. The majority (90%) felt that results could assist with contact tracing by prioritizing patients with likely recent infection. However, only a few centres have currently incorporated RITA into their HIV partner notification protocols. RITA has been introduced into clinical practice with no reported patient adverse events. Access to results at centre level should be improved. National guidance regarding use of RITA as a tool for contact tracing is required. © 2012 British HIV Association.

  3. Te Rita Papesch: Case Study of an Exemplary Learner of Maori as an Additional Language

    ERIC Educational Resources Information Center

    Ratima, Matiu Tai; Papesch, Te Rita

    2014-01-01

    This paper presents a case study of the life experiences of one exemplar adult second language Maori learner--Te Rita Papesch. Te Rita was one of 17 participants who were interviewed as a part of the first author's PhD study which sought to answer the question: what factors lead to the development of proficiency in te reo Maori amongst adult…

  4. Revegetation practices on the Santa Rita Experimental Range

    Treesearch

    Bruce D. Munda; Mark J. Pater

    2003-01-01

    This paper discusses the revegetation activites on the Santa Rita Experimental Range since 1903. Revegetation research includes experiments to evaluate adaptation, seedbed preparation, and sowing methods. We also discuss criteria used to determine if a site has the potential for a successful revegetation. Successful revegetation was initially based on plant emergence...

  5. Shelf sediment transport during hurricanes Katrina and Rita

    NASA Astrophysics Data System (ADS)

    Xu, Kehui; Mickey, Rangley C.; Chen, Qin; Harris, Courtney K.; Hetland, Robert D.; Hu, Kelin; Wang, Jiaze

    2016-05-01

    Hurricanes can greatly modify the sedimentary record, but our coastal scientific community has rather limited capability to predict hurricane-induced sediment deposition. A three-dimensional sediment transport model was developed in the Regional Ocean Modeling System (ROMS) to study seabed erosion and deposition on the Louisiana shelf in response to Hurricanes Katrina and Rita in the year 2005. Sensitivity tests were performed on both erosional and depositional processes for a wide range of erosional rates and settling velocities, and uncertainty analysis was done on critical shear stresses using the polynomial chaos approximation method. A total of 22 model runs were performed in sensitivity and uncertainty tests. Estimated maximum erosional depths were sensitive to the inputs, but horizontal erosional patterns seemed to be controlled mainly by hurricane tracks, wave-current combined shear stresses, seabed grain sizes, and shelf bathymetry. During the passage of two hurricanes, local resuspension and deposition dominated the sediment transport mechanisms. Hurricane Katrina followed a shelf-perpendicular track before making landfall and its energy dissipated rapidly within about 48 h along the eastern Louisiana coast. In contrast, Hurricane Rita followed a more shelf-oblique track and disturbed the seabed extensively during its 84-h passage from the Alabama-Mississippi border to the Louisiana-Texas border. Conditions to either side of Hurricane Rita's storm track differed substantially, with the region to the east having stronger winds, taller waves and thus deeper erosions. This study indicated that major hurricanes can disturb the shelf at centimeter to meter levels. Each of these two hurricanes suspended seabed sediment mass that far exceeded the annual sediment inputs from the Mississippi and Atchafalaya Rivers, but the net transport from shelves to estuaries is yet to be determined. Future studies should focus on the modeling of sediment exchange between

  6. Santa Rita Experimental Range digital database: user's guide

    Treesearch

    Mitchel P. McClaran; Deborah L. Angell; Craig Wissler

    2002-01-01

    Long-term measurements and repeat photograph collections have been collected in a systematic manner on the approximately 21,000 ha Santa Rita Experimental Range (SRER) since its establishment in 1903. This research facility, located in the Desert Grassland vegetation of southern Arizona, was administered by the U.S. Department of Agriculture until 1988, when it was...

  7. Resilience of Professional Counselors Following Hurricanes Katrina and Rita

    ERIC Educational Resources Information Center

    Lambert, Simone F.; Lawson, Gerard

    2013-01-01

    Professional counselors who provided services to those affected by Hurricanes Katrina and Rita completed the K6+ (screen for severe mental illness), the Posttraumatic Growth Inventory, and the Professional Quality of Life Scale. Results indicated that participants who survived the hurricanes had higher levels of posttraumatic growth than…

  8. RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses.

    PubMed

    Saha, Manujendra N; Jiang, Hua; Mukai, Asuka; Chang, Hong

    2010-11-01

    Mutations or deletions of p53 are relatively rare in multiple myeloma (MM), at least in newly diagnosed patients. Thus, restoration of p53 tumor suppressor function in MM by blocking the inhibitory role of murine double minute 2 (MDM2) is a promising and applicable therapeutic strategy. RITA and nutlin are two new classes of small molecule MDM2 inhibitors that prevent the p53-MDM2 interaction. Earlier reports showed p53-dependent activity of RITA in solid tumors as well as in leukemias. We and others recently described nutlin-induced apoptosis in MM cells, but it remains unclear whether RITA exerts antimyeloma activity. Here, we found that RITA activates the p53 pathway and induces apoptosis in MM cell lines and primary MM samples, preferentially killing myeloma cells. The activation of p53 induced by RITA was mediated through modulation of multiple apoptotic regulatory proteins, including upregulation of a proapoptotic protein (NOXA), downregulation of an antiapoptotic protein, Mcl-1, and activation of caspases through extrinsic pathways. Moreover, a number of key p53-mediated apoptotic target genes were identified by gene expression profiling and further validated by quantitative real-time PCR. Importantly, the combination of RITA with nutlin displayed a strong synergism on growth inhibition with the combination index ranging from 0.56 to 0.82 in MM cells. Our data support further clinical evaluation of RITA as a potential novel therapeutic intervention in MM. ©2010 AACR.

  9. Vortex Rossby Waves in Hurricanes Katrina and Rita (2005)

    NASA Astrophysics Data System (ADS)

    Judt, F.; Chen, S. S.

    2007-12-01

    Radar observations in hurricanes reveal inner spiraling rainbands emanating from the eyewall and propagating outward. Theoretical analysis indicated that these inner bands are azimuthally and radially propagating vortex Rossby waves (VRW). The outward propagating waves convey PV from the inner core to outer regions and thus lead to PV redistribution within a hurricane. It has been hypothesized that the outward propogating VRWs may play a role in interacting with an existing secondary PV ring in the outer region of a hurricane, which could lead to a development of concentric eyewalls. However, the lack of simultaneous observations over the inner-core and rainband regions is a major difficulty in our understanding of the complex interaction. The importance of VRWs in hurricane intensity change remains to be a question. This study aims to address the question using high- resolution model (MM5) forecasts of Hurricanes Katrina and Rita during the Hurricane Rainbands and Intensity Change Experiment (RAINEX) in 2005. The two major hurricanes went through a similar rapid intensification over the Gulf of Mexico. Both RAINEX observations and model forecast fields showed that Rita developed a secondary eyewall and went through an eyewall replacement before landfall, whereas Katrina did not. We analyze the model output at 1.67 km grid-resolution with 12-min time intervals. Azimuthally and radially propagating VRWs were found in the PV, rainrate, and vertical velocity fields in both storms. In the case of Katrina, no secondary PV maximum exists due to the lack of highly circular rainbands. Thus the VRWs propagate outward smoothly over a relatively long distance. No VRW activity has been found beyond 80-100 km radius in Katrina. This result indicates that interaction between the VRWs and outer PV disturbance must take place within this region, otherwise no effect concerning the importance of VRW would occur. The stagnation radius depends on the background PV- gradient which

  10. Cultural resources of the Santa Rita Experimental Range

    Treesearch

    John H. Madsen

    2003-01-01

    The Santa Rita Experimental Range is a vast open space with few signs of houses or human habitation, but at one time it was quite the opposite scene. Archaeological surface inspections reveal heavy use of the Range dating back hundreds of years. This paper will review the history of cultural resource management on the Range and provide a timeline of local cultural...

  11. Recent results on qualification of the RITA components for the ARTEMIS satellite

    NASA Astrophysics Data System (ADS)

    Bassner, H.; Berg, H.-P.; Kukies, R.

    1992-07-01

    An improved version of RITA, a radiofrequency ion thruster assembly, is planned to be used as part of the Ion Propulsion Package of an experimental communication satellite, ARTEMIS, now under development in Europe. The Ion Propulsion Package will be used to perform north/south stationkeeping as a responsible subsystem during 10 years of satellite operation. For this purpose, the thrust level of RITA has been increased from 10 to 15 mN. A complete redesign of the Power Supply and Control Unit will simplify the control of the thruster and neutralizer and decrease the number of parts in this electronic unit. The RF generator has been redesigned using latest technology. Results of lifetime and function tests are reported.

  12. Seismic Reflection Imaging of the Tucson Basin and Subsurface Relations Between the Catalina Detachment System and the Santa Rita Fault, SE Arizona

    NASA Astrophysics Data System (ADS)

    Wagner, F. T.; Johnson, R. A.

    2003-12-01

    Industry seismic reflection data collected in SE Arizona in the 1970's imaged the structure of the Tucson basin, the low-angle Catalina detachment fault, and the Santa Rita fault. Recent reprocessing of these data, including detailed near-surface statics compensation and modern event-migration techniques, have served to better focus the subsurface images. The Tucson basin occupies an area of approximately 2600 km2 and is bounded to the northeast by the Catalina-Rincon metamorphic core complex and to the south by the Santa Rita Mountains. The basin is characterized by an apparent half-graben structure down dropped along the eastern side and filled with up to 3700 m of Oligocene to recent volcanic and sedimentary rocks. In the northern portion of the basin, the gently-dipping ( ˜30 degrees) Catalina detachment fault is imaged from the western flank of the core complex dipping to the southwest beneath the Tucson basin. The detachment surface is evident to several seconds two-way-time in the seismic data and is characterized by broad corrugations parallel to extension with wavelengths of tens of kilometers. In the southern portion of the basin, the Santa Rita fault is imaged at the northwest side of the Santa Rita Mountains and dips ˜20 degrees to the northwest beneath the Tucson basin. Large, rotated hanging-wall blocks are also imaged above both the Catalina detachment and Santa Rita faults. While the Catalina detachment fault is no longer active, geomorphic analysis of fault scarps along the western flank of the Santa Rita Mountains supports recent (60-100 ka) movement on the Santa Rita fault. Preliminary results indicate that the Santa Rita fault terminates against the Catalina detachment fault beneath the central basin, suggesting that the recent movement observed on this fault may be, in part, a reactivation of the older fault surface.

  13. Recognizing history in range ecology: 100 years of science and management on the Santa Rita Experimental Range

    Treesearch

    Nathan F. Sayre

    2003-01-01

    At the centennial of the Santa Rita Experimental Range, historical analysis is called for on two levels. First, as a major site in the history of range ecology, the Santa Rita illuminates past successes and failures in science and management and the ways in which larger social, economic, and political factors have shaped scientific research. Second, with the turn away...

  14. Metal concentrations in schoolyard soils from New Orleans, Louisiana before and after Hurricanes Katrina and Rita.

    PubMed

    Presley, Steven M; Abel, Michael T; Austin, Galen P; Rainwater, Thomas R; Brown, Ray W; McDaniel, Les N; Marsland, Eric J; Fornerette, Ashley M; Dillard, Melvin L; Rigdon, Richard W; Kendall, Ronald J; Cobb, George P

    2010-06-01

    The long-term environmental impact and potential human health hazards resulting from Hurricanes Katrina and Rita throughout much of the United States Gulf Coast, particularly in the New Orleans, Louisiana, USA area are still being assessed and realized after more than four years. Numerous government agencies and private entities have collected environmental samples from throughout New Orleans and found concentrations of contaminants exceeding human health screening values as established by the United States Environmental Protection Agency (USEPA) for air, soil, and water. To further assess risks of exposure to toxic concentrations of soil contaminants for citizens, particularly children, returning to live in New Orleans following the storms, soils collected from schoolyards prior to Hurricane Katrina and after Hurricane Rita were screened for 26 metals. Concentrations exceeding USEPA Regional Screening Levels (USEPA-RSL), total exposure, non-cancer endpoints, for residential soils for arsenic (As), iron (Fe), lead (Pb), and thallium (Tl) were detected in soil samples collected from schoolyards both prior to Hurricane Katrina and after Hurricane Rita. Approximately 43% (9/21) of schoolyard soils collected prior to Hurricane Katrina contained Pb concentrations greater than 400mgkg(-1), and samples from four schoolyards collected after Hurricane Rita contained detectable Pb concentrations, with two exceeding 1700mgkg(-1). Thallium concentrations exceeded USEPA-RSL in samples collected from five schoolyards after Hurricane Rita. Based upon these findings and the known increased susceptibility of children to the effects of Pb exposure, a more extensive assessment of the soils in schoolyards, public parks and other residential areas of New Orleans for metal contaminants is warranted. 2010 Elsevier Ltd. All rights reserved.

  15. RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling.

    PubMed

    Zhu, Hong; Abulimiti, Muyasha; Liu, Huan; Su, Xiang-Jiang; Liu, Cai-Hong; Pei, Hai-Ping

    2015-09-01

    Radiation therapy is the most widely used treatment for patients with cervical cancer. Recent studies have shown that endoplasmic reticulum (ER) stress induces apoptosis and sensitizes tumor cells to radiotherapy, which reportedly induces ER stress in cells. Classical key tumor suppressor p53 is involved in the response to a variety of cellular stresses, including those incurred by ionizing irradiation. A recent study demonstrated that small-molecule RITA (reactivation of p53 and induction of tumor cell apoptosis) increased the radiosensitivity of tumor cells expressing mutant p53 (mtp53). In the present study, we explored the effects and the underlying mechanisms of RITA in regards to the radiosensitivity and ER stress in mtp53-expressing human cervix cancer cells. Treatment with 1 µM of RITA for 24 h before irradiation markedly decreased survival and increased apoptosis in C-33A and HT-3 cells; the effects were not significantly altered by knockdown of p53. In the irradiated C-33A and HT-3 cells, RITA significantly increased the expression of IRE1α, the spliced XBP1 mRNA level, as well as apoptosis; the effects were abolished by knockdown of IRE1α. Transcriptional pulse-chase assays revealed that RITA significantly increased the stability of IRE1α mRNA in the irradiated C-33A and HT-3 cells. In contrast, the same RITA treatment did not show any significant effect on sham-irradiated cells. In conclusion, the present study provides initial evidence that RITA upregulates the expression level of IRE1α by increasing the stability of IRE1α mRNA in irradiated mtp53-expressing cervical cancer cells; the effect leads to enhanced IRE1α/XBP1 ER stress signaling and increased apoptosis in the cells. The present study offers novel insight into the pharmacological potential of RITA in the radiotherapy for cervical cancer.

  16. Efficient synthesis of RITA and its analogues: derivation of analogues with improved antiproliferative activity via modulation of p53/miR-34a pathway.

    PubMed

    Lin, Jinshun; Jin, Xiuli; Bu, Yiwen; Cao, Deliang; Zhang, Nannan; Li, Shangfu; Sun, Qinsheng; Tan, Chunyan; Gao, Chunmei; Jiang, Yuyang

    2012-12-28

    A novel approach to synthesize RITA by practical palladium-catalyzed C-C bond-forming Suzuki reactions at room temperature was developed, which was used for deriving a series of substituted tricyclic α-heteroaryl (furan/thiophene) analogues of RITA under mild conditions. These novel analogues showed notable antiproliferative activity against cancer cell lines with wild-type p53 (i.e., HCT116, A549, MCF-7 and K562), but much less activity in HCT116/p53(-/-) cells. In particular, compound 1f demonstrated promising antiproliferative activity compared to RITA, with IC(50) = 28 nM in MCF-7 vs. 54 nM for RITA, and cancer cell selectivity. Compound 1f markedly activated p53 in HCT116 cells at 100 nM, triggering apoptosis. Importantly, we found that both RITA and compound 1f induced G(0)/G(1) cell cycle arrest by up-regulating miR-34a, which in turn down-regulated the expression of cell cycle-related proteins CDK4 and E2F1. In summary, this study reports an effective synthetic approach for RITA and its analogues, and elucidates a novel antiproliferative mechanism of these compounds.

  17. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.

    PubMed

    Zhao, Carolyn Ying; Szekely, Laszlo; Bao, Wenjie; Selivanova, Galina

    2010-04-15

    Proteasomal degradation of p53 by human papilloma virus (HPV) E6 oncoprotein plays a pivotal role in the survival of cervical carcinoma cells. Abrogation of HPV-E6-dependent p53 destruction can therefore be a good strategy to combat cervical carcinomas. Here, we show that a small-molecule reactivation of p53 and induction of tumor cell apoptosis (RITA) is able to induce the accumulation of p53 and rescue its tumor suppressor function in cells containing high-risk HPV16 and HPV18 by inhibiting HPV-E6-mediated proteasomal degradation. RITA blocks p53 ubiquitination by preventing p53 interaction with E6-associated protein, required for HPV-E6-mediated degradation. RITA activates the transcription of proapoptotic p53 targets Noxa, PUMA, and BAX, and repressed the expression of pro-proliferative factors CyclinB1, CDC2, and CDC25C, resulting in p53-dependent apoptosis and cell cycle arrest. Importantly, RITA showed substantial suppression of cervical carcinoma xenografts in vivo. These results provide a proof of principle for the treatment of cervical cancer in a p53-dependent manner by using small molecules that target p53. (c)2010 AACR.

  18. Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer

    PubMed Central

    Espinoza-Fonseca, L Michel

    2005-01-01

    Background The use of low-molecular-weight, non-peptidic molecules that disrupt the interaction between the p53 tumor suppressor and its negative regulator MDM2 has provided a promising alternative for the treatment of different types of cancer. Among these compounds, RITA (reactivation of p53 and induction of tumor cell apoptosis) has been shown to be effective in the selective induction of apoptosis, and this effect is due to its binding to the p53 tumor suppressor. Since biological systems are highly dynamic and MDM2 may bind to different regions of p53, new alternatives should be explored. On this basis, the computational "blind docking" approach was employed in this study to see whether RITA would bind to MDM2. Results It was observed that RITA binds to the MDM2 p53 transactivation domain-binding cleft. Thus, RITA can be used as a lead compound for designing improved "multi-target" drugs. This novel strategy could provide enormous benefits to enable effective anti-cancer strategies. Conclusion This study has demonstrated that a single molecule can target at least two different proteins related to the same disease. PMID:16174299

  19. p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA.

    PubMed

    Hedström, Elisabeth; Eriksson, Sofi; Zawacka-Pankau, Joanna; Arnér, Elias S J; Selivanova, Galina

    2009-11-01

    Thioredoxin reductase 1 (TrxR1) is a key regulator in many redox-dependent cellular pathways, and is often overexpressed in cancer. Several studies have identified TrxR1 as a potentially important target for anticancer therapy. The low molecular weight compound RITA (NSC 652287) binds p53 and induces p53-dependent apoptosis. Here we found that RITA also targets TrxR1 by non-covalent binding, followed by inhibition of its activity in vitro and by inhibition of TrxR activity in cancer cells. Interestingly, a novel approximately 130 kDa form of TrxR1, presumably representing a stable covalently linked dimer, and an increased generation of reactive oxygen species (ROS) were induced by RITA in cancer cells in a p53-dependent manner. Similarly, the gold-based TrxR inhibitor auranofin induced apoptosis related to oxidative stress, but independently of p53 and without apparent induction of the approximately 130 kDa form of TrxR1. In contrast to the effects observed in cancer cells, RITA did not inhibit TrxR or ROS formation in normal fibroblasts (NHDF). The inhibition of TrxR1 can sensitize tumor cells to agents that induce oxidative stress and may directly trigger cell death. Thus, our results suggest that a unique p53-dependent effect of RITA on TrxR1 in cancer cells might synergize with p53-dependent induction of pro-apoptotic genes and oxidative stress, thereby leading to a robust induction of cancer cell death, without affecting non-transformed cells.

  20. Lightcurves for Shape Modeling: 852 Wladilena, 1089 Tama, and 1180 Rita

    NASA Astrophysics Data System (ADS)

    Polishook, David

    2012-10-01

    The folded lightcurves and synodic periods of 852 Wladilena, 1089 Tama, and 1180 Rita are reported. The data are used by Hanus et al. (2012) to derive the rotation axis and to construct a shape model by applying the inversion lightcurve technique.

  1. Swamp tours in Louisiana post Hurricane Katrina and Hurricane Rita

    Treesearch

    Dawn J. Schaffer; Craig A. Miller

    2007-01-01

    Hurricanes Katrina and Rita made landfall in southern Louisiana during August and September 2005. Prior to these storms, swamp tours were a growing sector of nature-based tourism that entertained visitors while teaching about local flora, fauna, and culture. This study determined post-hurricane operating status of tours, damage sustained, and repairs made. Differences...

  2. Historical and recent flora of the Santa Rita Experimental Range

    Treesearch

    Alvin L. Medina

    2003-01-01

    The historical flora of the Santa Rita Experimental Range was composed from historical lists of plants collected by various investigators since 1903. Plant accessions were verified from lists of plant specimens housed at the Rocky Mountain Research Station herbarium in Flagstaff, AZ, and the Rocky Mountain National Herbarium in Laramie, WY. Recent additions (1980 to...

  3. The impact of Hurricane Rita on an academic institution: lessons learned.

    PubMed

    Beggan, Dominic M

    2010-01-01

    This paper examines the impact of Hurricane Rita on one of the many universities along the Gulf Coast of the United States: Lamar University in Beaumont, Texas. Hurricane Rita, which made landfall between Sabine Pass, Texas, and Johnson's Bayou, Louisiana, on 24 September 2005, is the fourth strongest Atlantic Ocean hurricane on record and the most intense tropical cyclone ever observed in the Gulf of Mexico. This paper assesses the tasks that confronted the administration, faculty, and students of Lamar University in the days and weeks after the event. It concludes that the one factor that will influence more than any other the degree of success after any disaster is whether all levels of the administrative command institutionalise, endorse, promote, and encourage the adopted recovery plan. The research seeks to share valuable insights on the vulnerabilities that academic institutions face during natural disasters and to highlight some of the many lessons learned.

  4. Effects of hurricanes Katrina and Rita on the chemistry of bottom sediments in Lake Pontchartrain, Louisiana, USA

    USGS Publications Warehouse

    Van Metre, P.C.; Horowitz, A.J.; Mahler, B.J.; Foreman, W.T.; Fuller, C.C.; Burkhardt, M.R.; Elrick, K.A.; Furlong, E.T.; Skrobialowski, S.C.; Smith, J.J.; Wilson, J.T.; Zaugg, S.D.

    2006-01-01

    The effects of Hurricanes Katrina and Rita and the subsequent unwatering of New Orleans, Louisiana, on the sediment chemistry of Lake Pontchartrain were evaluated by chemical analysis of samples of street mud and suspended and bottom sediments. The highest concentrations of urban-related elements and compounds (e.g., Pb, Zn, polycyclic aromatic hydrocarbons, and chlordane) in bottom sediments exceeded median concentrations in U.S. urban lakes and sediment-quality guidelines. The extent of the elevated concentrations was limited, however, to within a few hundred meters of the mouth of the 17th Street Canal, similar to results of historical assessments. Chemical and radionuclide analysis of pre- and post-Hurricane Rita samples indicates that remobilization of near-shore sediment by lake currents and storms is an ongoing process. The effects of Hurricanes Katrina and Rita on the sediment chemistry of Lake Pontchartrain are limited spatially and are most likely transitory. ?? 2006 American Chemical Society.

  5. Soil and ecological sites of the Santa Rita Experimental Range

    Treesearch

    Donald J. Breckenfeld; Daniel Robinett

    2003-01-01

    A soil survey and rangeland resource inventory of the Santa Rita Experimental Range (SRER) was conducted by staff from the Tucson office of the Natural Resources Conservation Service (NRCS) during April and May of 1997. Thirty-two soils series and taxadjuncts were mapped on the SRER and delineated in 24 different mapping units. These soils all occur in an Aridic and...

  6. Sir John and Lady Rita Cornforth: a distinguished chemical partnership.

    PubMed

    Purchase, Rupert; Hanson, James R

    2015-01-01

    This review describes the life of Sir John Cornforth AC CBE FRS, who was awarded the Nobel Prize for Chemistry in 1975. It covers his early life in Australia, his work in Oxford, the National Institute for Medical Research, the Milstead Laboratory of Chemical Enzymology and the University of Sussex, together with the contributions made by his wife, Lady Rita Cornforth.

  7. A Green Prison: The Santa Rita Jail Campus Microgrid

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marnay, Chris; DeForest, Nicholas; Lai, Judy

    2012-01-22

    A large microgrid project is nearing completion at Alameda County’s twenty-two-year-old 45 ha 4,000-inmate Santa Rita Jail, about 70 km east of San Francisco. Often described as a green prison, it has a considerable installed base of distributed energy resources (DER) including an eight-year old 1.2 MW PV array, a five-year old 1 MW fuel cell with heat recovery, and considerable efficiency investments. A current US$14 M expansion adds a 2 MW-4 MWh Li-ion battery, a static disconnect switch, and various controls upgrades. During grid blackouts, or when conditions favor it, the Jail can now disconnect from the grid andmore » operate as an island, using the on-site resources described together with its back-up diesel generators. In other words, the Santa Rita Jail is a true microgrid, or μgrid, because it fills both requirements, i.e. it is a locally controlled system, and it can operate both grid connected and islanded. The battery’s electronics includes Consortium for Electric Reliability Technology (CERTS) Microgrid technology. This enables the battery to maintain energy balance using droops without need for a fast control system.« less

  8. Integration& Operation of a Microgrid at Santa Rita Jail

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chevron Energy Solutions; Alameda County; DeForest, Nicholas

    2011-05-01

    Santa Rita Jail is a 4,500 inmate facility located in Dublin CA, approximately 40 miles (65 km) east of San Francisco. Over the past decade, a series of Distributed Energy Resources (DER) installations and efficiency measures have been undertaken to transform the 3MW facility into a"Green Jail". These include a 1.2MW rated rooftop PV system installed in 2002, a 1MW molten carbonate fuel cell with CHP, and retrofits to lighting and HVAC systems to reduce peak loads. With the upcoming installation of a large-scale battery and fast static disconnect switch, Santa Rita Jail will become a true microgrid, with fullmore » CERTS Microgrid functionality. Consequently, the jail will be able to seamlessly disconnect from the grid and operate as an island in the event of a disturbance, reconnecting again once the disturbance has dissipated. The extent to which that jail is capable of islanding is principally dependant on the energy capacity of the battery-one focus of this investigation. Also presented here are overviews of the DER currently installed at the jail, as well as the value it provides by offsetting the purchase of electricity under the current Pacific Gas& Electric (PG&E) tariff.« less

  9. A randomized comparison of the Saphenous Vein Versus Right Internal Thoracic Artery as a Y-Composite Graft (SAVE RITA) trial: One-year angiographic results and mid-term clinical outcomes.

    PubMed

    Kim, Ki-Bong; Hwang, Ho Young; Hahn, Seokyung; Kim, Jun Sung; Oh, Se Jin

    2014-09-01

    The Saphenous Vein Versus Right Internal Thoracic Artery as a Y-Composite Graft (SAVE RITA) trial was designed to evaluate the noninferiority of the saphenous vein (SV) compared with the right internal thoracic artery ([R]ITA) used as a Y-composite graft. A total of 224 patients who had undergone off-pump revascularization for multivessel coronary artery disease using the SV or RITA as a Y-composite graft based on the in situ left ITA were assigned randomly to the SV Y-composite graft (SV group, n = 112) or free RITA Y-composite graft (RITA group, n = 112). The primary endpoint was the 1-year angiographic patency rate of the second limb conduits (SV or RITA). Postoperative 1-year coronary angiograms were performed in 215 patients (SV group, 108; RITA group, 107). The overall graft patency rate was 97.4% (745 of 765) at 1 year (97.9% in the SV group vs 96.9% in the RITA group, P = .362). The primary endpoint of the study, the 1-year patency rate of the SV composite grafts, was 97.1% (238 of 245) and was noninferior to that of the RITA composite grafts (97.1% [198 of 204]) with a 95% lower confidence limit of -2.6% (P < .001 for noninferiority). The graft qualities, evaluated using the FitzGibbon patency grades, were also similar between the 2 groups (P = .948). No statistically significant differences were found in the overall survival rates between the 2 groups at 1 and 4 years (P = .998). Also, no statistically significant differences were found between the 2 groups in the freedom from major adverse cardiac and cerebrovascular event rates at 1 and 4 years (P = .597). The SV composite grafts were noninferior to the RITA composite grafts in terms of the 1-year angiographic patency rates. Copyright © 2014 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

  10. The RITA spectrometer at Risø - design considerations and recent results

    NASA Astrophysics Data System (ADS)

    Clausen, K. N.; McMorrow, D. F.; Lefmann, K.; Aeppli, G.; Mason, T. E.; Schröder, A.; Issikii, M.; Nohara, M.; Takagi, H.

    In the new cold triple axis spectrometer RITA at Risø we have improved the front end by extensive use of state of the art optical elements and better shielding material. The analyser system is situated in one large open tank and consists of seven individually orientable PG(002) crystal analyser blades, and a 170 mm by 120 mm 2 areas sensitive micro-strip detector. In comparison to the old TAS6 spectrometer we have obtained a factor 2-5 gain in intensity on the sample, a substantially lower background, much more flexibility for optimising the instrument and the possibility to go beyond simple point-by-point inspection. The excellent performance of RITA in the standard TAS mode is exemplified by a study of the dynamics of ≈ 15 nm hematite (α-Fe 2O 3) nano-particles, and utilisation of horizontal and vertical focusing modes to study two dimensional systems is illustrated by a study of the spin fluctuations in the high Tc superconductor La 1.83Sr 0.17CuO 4.

  11. Secondary eyewall formation in WRF simulations of Hurricanes Rita and Katrina (2005)

    NASA Astrophysics Data System (ADS)

    Abarca, Sergio F.; Corbosiero, Kristen L.

    2011-04-01

    An analysis is presented of two high-resolution hurricane simulations of Katrina and Rita (2005) that exhibited secondary eyewall formation (SEF). The results support the notion of vortex Rossby waves (VRWs) having an important role in SEF and suggest that VRW activity is a defining aspect of the moat. SEF occurs at a radius of ˜65 (80) km in Katrina (Rita), close to the hypothesized stagnation radius of VRWs. VRW activity appears to be the result of eye-eyewall mixing events, themselves a product of the release of barotropic instability. The convection in the radial region that becomes the moat is mainly in the form of VRWs propagating radially outward from the primary eyewall until the negative radial gradient of potential vorticity is no longer conducive for their propagation. These convectively coupled waves, originating and being expelled from the eyewall, are rotation dominated and have the coherency necessary to survive their passage through the strain-dominated region outside the eyewall.

  12. Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu).

    PubMed

    Luan, Jinwei; Li, Xianglan; Guo, Rutao; Liu, Shanshan; Luo, Hongyu; You, Qingshan

    2016-06-01

    Next generation sequencing and bio-informatic analyses were conducted to investigate the mechanism of reactivation of p53 and induction of tumor cell apoptosis (RITA)-enhancing X-ray susceptibility in FaDu cells. The cDNA was isolated from FaDu cells treated with 0 X-ray, 8 Gy X-ray, or 8 Gy X-ray + RITA. Then, cDNA libraries were created and sequenced using next generation sequencing, and each assay was repeated twice. Subsequently, differentially expressed genes (DEGs) were identified using Cuffdiff in Cufflinks and their functions were predicted by pathway enrichment analyses. Genes that were constantly up- or down-regulated in 8 Gy X-ray-treated FaDu cells and 8 Gy X-ray + RITA-treated FaDu cells were obtained as RITA genes. Afterward, the protein-protein interaction (PPI) relationships were obtained from the STRING database and a PPI network was constructed using Cytoscape. Furthermore, ClueGO was used for pathway enrichment analysis of genes in the PPI network. Total 2,040 and 297 DEGs were identified in FaDu cells treated with 8 Gy X-ray or 8 Gy X-ray + RITA, respectively. PARP3 and NEIL1 were enriched in base excision repair, and CDK1 was enriched in p53 signaling pathway. RFC2 and EZH2 were identified as RITA genes. In the PPI network, many interaction relationships were identified (e.g., RFC2-CDK1, EZH2-CDK1 and PARP3-EZH2). ClueGO analysis showed that RFC2 and EZH2 were related to cell cycle. RFC2, EZH2, CDK1, PARP3 and NEIL1 may be associated, and together enhance the susceptibility of FaDu cells treated with RITA to the deleterious effects of X-ray.

  13. Interaction of Environmental Moisture, Rainbands, and Inner-Core Dynamics in Hurricanes Katrina and Rita

    NASA Astrophysics Data System (ADS)

    Ortt, D.; Chen, S. S.

    2007-12-01

    The interaction of the environmental water vapor distribution around a tropical cyclone (TC), rainbands, and inner- core dynamics can affect hurricane structure and intensity change, which is not well understood. Although previous studies have addressed various aspects of this problem, a full three way interaction and its implications for hurricane intensity change has not been documented. Using data collected during the Hurricane Rainband and Intensity Experiment (RAINEX) in Hurricanes Katrina and Rita, the three way interaction of the environment moisture, rainbands, and inner-core dynamics can be evaluated. The TRMM TMI total precipitable water (PW) data with 1/4 degree horizontal resolution, TRMM TMI rainrate data with a 4 km horizontal resolution and the GPS dropsondes with a ½ second temporal resolution are used to characterize the environmental moisture. The high resolution model output from the real-time MM5 forecasts of Hurricanes Katrina and Rita are used to investigate the complex interactions in both storms. The model forecasts were made using a vortex-following nested grid with horizontal resolutions of 15, 5, and 1.67km, respectively. There were 28 vertical sigma levels. The Goddard microphysics scheme was used. The TRMM PW and the GPS dropsonde data show strong moisture gradients in the outer rainband region in Rita with a dry outer environment, which may contribute to the development of outer rainbands with a high circularity. It created a secondary ring of potential vorticity (PV). In addition, the vortex Rossby waves (VRW) propagating radialy outward from the eyewall were unable to propagate beyond the secondary ring of PV. The combination of these VRW and the environmental water vapor distribution may play a role in enhancing the rainbands that developed into a secondary eyewall, which leads to a temporary weakening of the hurricane. In contrast, Katrina had a relative weak moisture gradient surrounding the storm. There were not persistent outer

  14. Gambel and scaled quail diets on the Santa Rita Experimental Range

    Treesearch

    Alvin L. Medina

    2003-01-01

    Diets of Gambel (Lophortyx gambelii Gambel) and scaled quail (Callipepla squamata Vigors) from 1982 to 1984 were examined on the Santa Rita Experimental Range in southern Arizona. Quail selected some foods yearlong and others on a seasonal basis, but exhibited a preference for the seeds and leaves of forbs and insects. Seeds of bristlegrasses were selected primarily...

  15. The Impact of Hurricanes Katrina and Rita on Louisiana School Nurses

    ERIC Educational Resources Information Center

    Broussard, Lisa; Myers, Rachel; Meaux, Julie

    2008-01-01

    In the fall of 2005, the coast of Louisiana was devastated by two hurricanes, Katrina and Rita. Not only did these natural disasters have detrimental effects for those directly in their path, the storms had an impact on the lives of everyone in Louisiana. The professional practice of many Louisiana school nurses was affected by several factors,…

  16. Wildlife ecology and management, Santa Rita Experimental Range (1903 to 2002)

    Treesearch

    Paul R. Krausman; Michael L. Morrison

    2003-01-01

    The Santa Rita Experimental Range (SRER), established in 1903, is a natural laboratory used to better understand desert grasslands. We reviewed the literature to summarize studies that have been conducted on wildlife at SRER from 1903 to 2002 and to provide recommendations on expanding contemporary research at SRER. Research related to wild vertebrates has been limited...

  17. Damage to offshore infrastructure in the Gulf of Mexico by hurricanes Katrina and Rita

    NASA Astrophysics Data System (ADS)

    Cruz, A. M.; Krausmann, E.

    2009-04-01

    The damage inflicted by hurricanes Katrina and Rita to the Gulf-of-Mexico's (GoM) oil and gas production, both onshore and offshore, has shown the proneness of industry to Natech accidents (natural hazard-triggered hazardous-materials releases). In order to contribute towards a better understanding of Natech events, we assessed the damage to and hazardous-materials releases from offshore oil and natural-gas platforms and pipelines induced by hurricanes Katrina and Rita. Data was obtained through a review of published literature and interviews with government officials and industry representatives from the affected region. We also reviewed over 60,000 records of reported hazardous-materials releases from the National Response Center's (NRC) database to identify and analyze the hazardous-materials releases directly attributed to offshore oil and gas platforms and pipelines affected by the two hurricanes. Our results show that hurricanes Katrina and Rita destroyed at least 113 platforms, and severely damaged at least 53 others. Sixty percent of the facilities destroyed were built 30 years ago or more prior to the adoption of the more stringent design standards that went into effect after 1977. The storms also destroyed 5 drilling rigs and severely damaged 19 mobile offshore drilling units (MODUs). Some 19 MODUs lost their moorings and became adrift during the storms which not only posed a danger to existing facilities but the dragging anchors also damaged pipelines and other infrastructure. Structural damage to platforms included toppling of sections, and tilting or leaning of platforms. Possible causes for failure of structural and non-structural components of platforms included loading caused by wave inundation of the deck. Failure of rigs attached to platforms was also observed resulting in significant damage to the platform or adjacent infrastructure, as well as damage to equipment, living quarters and helipads. The failures are attributable to tie-down components

  18. Wetland Sedimentation from Hurricanes Katrina and Rita

    NASA Astrophysics Data System (ADS)

    Turner, R. Eugene; Baustian, Joseph J.; Swenson, Erick M.; Spicer, Jennifer S.

    2006-10-01

    More than 131 × 106 metric tons (MT) of inorganic sediments accumulated in coastal wetlands when Hurricanes Katrina and Rita crossed the Louisiana coast in 2005, plus another 281 × 106 MT when accumulation was prorated for open water area. The annualized combined amount of inorganic sediments per hurricane equals (i) 12% of the Mississippi River's suspended load, (ii) 5.5 times the inorganic load delivered by overbank flooding before flood protection levees were constructed, and (iii) 227 times the amount introduced by a river diversion built for wetland restoration. The accumulation from hurricanes is sufficient to account for all the inorganic sediments in healthy saltmarsh wetlands.

  19. Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma.

    PubMed

    Di Marzo, Domenico; Forte, Iris Maria; Indovina, Paola; Di Gennaro, Elena; Rizzo, Valeria; Giorgi, Francesca; Mattioli, Eliseo; Iannuzzi, Carmelina Antonella; Budillon, Alfredo; Giordano, Antonio; Pentimalli, Francesca

    2014-01-01

    Malignant mesothelioma, a very aggressive tumor associated to asbestos exposure, is expected to increase in incidence, and unfortunately, no curative modality exists. Reactivation of p53 is a new attractive antitumoral strategy. p53 is rarely mutated in mesothelioma, but it is inactivated in most tumors by the lack of p14(ARF). Here, we evaluated the feasibility of this approach in pleural mesothelioma by testing RITA and nutlin-3, two molecules able to restore p53 function through a different mechanism, on a panel of mesothelioma cell lines representing the epithelioid (NCI-H28, NCI-H2452, IST-MES 2), biphasic (MSTO-211H), and sarcomatoid (NCI-H2052) histotypes compared with the normal mesothelial HMC-hTERT. RITA triggered robust caspase-dependent apoptosis specifically in epithelioid and biphasic mesothelioma cell lines, both through wild-type and mutant p53, concomitant to p21 downregulation. Conversely, nutlin-3 induced a p21-dependent growth arrest, rather than apoptosis, and was slightly toxic on HMC-hTERT.   Interestingly, we identified a previously undetected point mutation of p53 (p.Arg249Ser) in IST-MES 2, and showed that RITA is also able to reactivate this p53 mutant protein and its apoptotic function. RITA reduced tumor growth in a MSTO-211H-derived xenograft model of mesothelioma and synergized with cisplatin, which is the mainstay of treatment for this tumor. Our data indicate that reactivation of p53 and concomitant p21 downregulation effectively induce cell death in mesothelioma, a tumor characterized by a high intrinsic resistance to apoptosis. Altogether, our findings provide the preclinical framework supporting the use of p53-reactivating agents alone, or in combination regimens, to improve the outcome of patients with mesothelioma.

  20. Effects of marsh pond terracing on coastal wintering waterbirds before and after Hurricane Rita.

    PubMed

    O'Connell, Jessica L; Nyman, John A

    2011-11-01

    From February to March 2005-2006, we surveyed wintering waterbirds to test effects of terracing on coastal pond use before and after Hurricane Rita. Marsh terracing is intended to slow coastal marsh loss in the Chenier Plain by slowing marsh erosion and encouraging vegetation expansion. Terraces also increase marsh edge in ponds, possibly benefiting waterbirds. We monitored paired terraced and unterraced ponds in three sites within southwestern Louisiana's Chenier Plain. Waterbirds were 75% more numerous in terraced than unterraced ponds. Waterbird richness was similar among ponds when corrected for number of individuals, suggesting terracing increased bird density but did not provide habitat unique from unterraced ponds. Birds were 93% more numerous following Hurricane Rita, mostly due to an influx of migrating waterfowl. Year round residents were similar in number before and after Hurricane Rita. Resident richness did not differ among years after correcting for number of observed individuals. Wading and dabbling foragers were more abundant in terraced ponds and these two guilds represented 74% of birds observed. We detected no difference among ponds for other guilds, i.e., probing, aerial, and diving foragers. Increasing proportion of mash edge increased bird density disproportionately: On average ponds with 10% edge had 6 birds observed and ponds with 30% edge had 16 birds observed. Terraces increased habitat interspersion and were an effective tool for increasing numbers of wintering waterfowl and wading birds. The extent to which terraces were sustainable following hurricane forces is unknown.

  1. Effects of Marsh Pond Terracing on Coastal Wintering Waterbirds Before and After Hurricane Rita

    NASA Astrophysics Data System (ADS)

    O'Connell, Jessica L.; Nyman, John A.

    2011-11-01

    From February to March 2005-2006, we surveyed wintering waterbirds to test effects of terracing on coastal pond use before and after Hurricane Rita. Marsh terracing is intended to slow coastal marsh loss in the Chenier Plain by slowing marsh erosion and encouraging vegetation expansion. Terraces also increase marsh edge in ponds, possibly benefiting waterbirds. We monitored paired terraced and unterraced ponds in three sites within southwestern Louisiana's Chenier Plain. Waterbirds were 75% more numerous in terraced than unterraced ponds. Waterbird richness was similar among ponds when corrected for number of individuals, suggesting terracing increased bird density but did not provide habitat unique from unterraced ponds. Birds were 93% more numerous following Hurricane Rita, mostly due to an influx of migrating waterfowl. Year round residents were similar in number before and after Hurricane Rita. Resident richness did not differ among years after correcting for number of observed individuals. Wading and dabbling foragers were more abundant in terraced ponds and these two guilds represented 74% of birds observed. We detected no difference among ponds for other guilds, i.e., probing, aerial, and diving foragers. Increasing proportion of mash edge increased bird density disproportionately: On average ponds with 10% edge had 6 birds observed and ponds with 30% edge had 16 birds observed. Terraces increased habitat interspersion and were an effective tool for increasing numbers of wintering waterfowl and wading birds. The extent to which terraces were sustainable following hurricane forces is unknown.

  2. REMOTE SENSING DAMAGE ASSESSMENT OF CHEMICAL PLANTS AND REFINERIES FOLLOWING HURRICANES KATRINA AND RITA

    EPA Science Inventory

    The massive destruction brought by Hurricanes Katrina and Rita also impacted the many chemical plants and refineries in the region. The achievement of this rapid analysis capability highlights the advancement of this technology for air quality assessment and monitoring. Case st...

  3. Ritacestus gen. n. (Cestoda: Proteocephalidea) and redescription of R. ritaii comb. n., a parasite of Rita rita (Siluriformes) in India.

    PubMed

    de Chambrier, Alain; Scholz, Tomás; Ash, Anirban; Kar, Pradip Kumar

    2011-11-01

    A new genus, Ritacestus, is proposed to accommodate Ritacestus ritaii (Verma, 1926) comb. n. (syn. Proteocephalus ritaii), a parasite of the catfish Rita rita (Hamilton) in India. The new genus, which is placed in the Gangesiinae, is characterized by (i) a small, subspherical scolex formed by four large lobes separated from one another by longitudinal grooves, with a large, widely oval to pyriform rostellum-like apical organ, larger than suckers and possessing an apical hemispherical depression; (ii) paramuscular and cortical position of some vitelline follicles (most follicles are situated medullary); (iii) ventral and dorsal bands of vitelline follicles usually uninterrupted ventral to terminal genitalia and reaching to the posterior margin of proglottides; (iv) the vagina always anterior to the cirrus-sac; (v) a large size of the body (length up to 51 cm); and (vi) development of the uterus of type 2. In its morphology, especially shape of the scolex and apical organ, and paramuscular and cortical position of some vitelline follicles, Ritacestus resembles Postgangesia Akhmerov, 1969, but differs in the presence of a genital atrium (both genital pores of Postgangesia are separate), the anterior position of the vagina (almost always posterior in the latter genus), position of vitelline follicles in cross sections (dorsal and ventral bands in Ritacestus versus only a lateral band in the latter genus), and dorsal excretory canals indistinguishable in mature and gravid proglottides of R. ritaii (well developed in Postgangesia spp.). The type and only species of the genus, R. ritaii, is redescribed on the basis of new material from the type host from the Ganges River basin in India and its neotype is designated.

  4. External factors impacting hospital evacuations caused by Hurricane Rita: the role of situational awareness.

    PubMed

    Downey, Erin L; Andress, Knox; Schultz, Carl H

    2013-06-01

    The 2005 Gulf Coast hurricane season was one of the most costly and deadly in US history. Hurricane Rita stressed hospitals and led to multiple, simultaneous evacuations. This study systematically identified community factors associated with patient movement out of seven hospitals evacuated during Hurricane Rita. This study represents the second of two systematic, observational, and retrospective investigations of seven acute care hospitals that reported off-site evacuations due to Hurricane Rita. Participants from each hospital included decision makers that comprised the Incident Management Team (IMT). Investigators applied a standardized interview process designed to assess evacuation factors related to external situational awareness of community activities during facility evacuation due to hurricanes. The measured outcomes were responses to 95 questions within six sections of the survey instrument. Investigators identified two factors that significantly impacted hospital IMT decision making: (1) incident characteristics affecting a facility's internal resources and challenges; and (2) incident characteristics affecting a facility's external evacuation activities. This article summarizes the latter and reports the following critical decision making points: (1) Emergency Operations Plans (EOP) were activated an average of 85 hours (3 days, 13 hours) prior to Hurricane Rita's landfall; (2) the decision to evacuate the hospital was made an average of 30 hours (1 day, 6 hours) from activation of the EOP; and (3) the implementation of the evacuation process took an average of 22 hours. Coordination of patient evacuations was most complicated by transportation deficits (the most significant of the 11 identified problem areas) and a lack of situational awareness of community response activities. All evacuation activities and subsequent evacuation times were negatively impacted by an overall lack of understanding on the part of hospital staff and the IMT regarding how to

  5. Sediment deposition from Hurricane Rita on Hackberry Beach chenier in southwestern Louisiana: Chapter 6E in Science and the storms-the USGS response to the hurricanes of 2005

    USGS Publications Warehouse

    Faulkner, Stephen; Barrow, Wylie; Doyle, Thomas; Baldwin, Michael; Michot, Thomas; Wells, Christopher; Jeske, Clint

    2007-01-01

    Hurricane Rita significantly impacted the chenier forests of southwestern Louisiana, an important habitat for Neotropical migratory birds. Sediment deposition was measured along transects at Hackberry Beach chenier, and Rita's effects on chenier structure and morphology were determined.

  6. Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro.

    PubMed

    Burmakin, Mikhail; Shi, Yao; Hedström, Elisabeth; Kogner, Per; Selivanova, Galina

    2013-09-15

    Restoration of the p53 function in tumors is a promising therapeutic strategy due to the high potential of p53 as tumor suppressor and the fact that established tumors depend on p53 inactivation for their survival. Here, we addressed the question whether small molecule RITA can reactivate p53 in neuroblastoma and suppress the growth of neuroblastoma cells in vitro and in vivo. The ability of RITA to inhibit growth and to induce apoptosis was shown in seven neuroblastoma cell lines. Mechanistic studies were carried out to determine the p53 dependence and the molecular mechanism of RITA-induced apoptosis in neuroblastoma, using cell viability assays, RNAi silencing, co-immunoprecipitation, qPCR, and Western blotting analysis. In vivo experiments were conducted to study the effect of RITA on human neuroblastoma xenografts in mice. RITA induced p53-dependent apoptosis in a set of seven neuroblastoma cell lines, carrying wild-type or mutant p53; it activated p53 and triggered the expression of proapoptotic p53 target genes. Importantly, p53 activated by RITA inhibited several key oncogenes that are high-priority targets for pharmacologic anticancer strategies in neuroblastoma, including N-Myc, Aurora kinase, Mcl-1, Bcl-2, Wip-1, MDM2, and MDMX. Moreover, RITA had a strong antitumor effect in vivo. Reactivation of wild-type and mutant p53 resulting in the induction of proapoptotic factors along with ablation of key oncogenes by compounds such as RITA may be a highly effective strategy to treat neuroblastoma. ©2013 AACR.

  7. Public Response to Hurricane Rita Forecasts Along the Texas Coast: An Undergraduate Research Study Linking Science and Society

    NASA Astrophysics Data System (ADS)

    Morss, R. E.; Zhang, F.

    2006-12-01

    One mechanism for creating more usable science is familiarizing scientists with societal use of and needs for scientific information. We will describe an effort to so in the university educational system, through a semester-long class for meteorology students that involved a research project on public perception and use of hurricane forecasts. Hurricane Rita made landfall near the Texas-Louisiana border in September 2005, causing major damage and disruption. As Rita approached the Gulf Coast, significant uncertainties in the track and intensity forecasts, combined with the aftermath of Hurricane Katrina, led to major evacuations along the Texas coast and significant traffic jams in the broader Houston area. In the spring semester of 2006, seven undergraduate and three graduate meteorology students at Texas A&M University participated in a student research project to investigate the societal impacts of Hurricane Rita and its forecasts. The research team, including the students, developed a structured interview questionnaire to explore coastal residents' hurricane preparation and evacuation decisions and their use and perception of Hurricane Rita forecasts. The students then conducted 120 in-person interviews in the Texas Gulf Coast cities of Galveston, Port Arthur, and Houston. The study was designed to both answer key research questions and provide students with first- hand knowledge about how the public perceives hurricane risk and uses weather forecasts. We will report findings from the survey, as well as the educational benefits described by the students. We hope that the project can serve as a model for classroom-based student research projects at other universities, to give more science students opportunities to learn first-hand about people's perceptions and use of scientific information.

  8. Lessons learned from the deadly sisters: drug and alcohol treatment disruption, and consequences from Hurricanes Katrina and Rita.

    PubMed

    Maxwell, Jane Carlisle; Podus, Deborah; Walsh, David

    2009-01-01

    This paper reports on the effects of Hurricanes Katrina and Rita on drug and alcohol treatment in Texas in 2005-2006. Findings are based on a secondary analysis of administrative data on 567 hurricane-related admissions and on interview data from a sample of 20 staff in 11 treatment programs. Katrina evacuees differed from Rita clients in terms of demographics and primary problem substances and treatment needs, while the experiences of program staff and needed changes to improve disaster readiness were more similar. Additional systematic research is needed to document the intermediate and long-term impacts of the storms in these and other affected areas.

  9. Sweet resin bush on the Santa Rita Experimental Range: An eradication effort

    Treesearch

    Larry D. Howery; Bruce D. Munda; Dan G. Robinett; Harry H. Buck

    2003-01-01

    Sweet resin bush (Euryops subcarnosus DC ssp. vulgaris B. Nord; or, Euryops multifidis (L. f.) DC.), a South African shrub introduced to Arizona in the 1930s, was discovered on the Santa Rita Experimental Range (SRER) in 1998. Due to the threat of spread of this invasive plant and its potential to cause adverse environmental and economic effects, and because it posed a...

  10. Hope in "Rita Hayworth and Shawshank Redemption": a human becoming hermeneutic study.

    PubMed

    Parse, Rosemarie Rizzo

    2007-04-01

    This article is the report of the human becoming hermeneutic method study on "Rita Hayworth and Shawshank Redemption" (the short story, the screenplay, and the film). The study unfolded during the Parse-King dialogue that answered the research question what is hope as humanly lived? Emergent meanings were discovered that enhanced knowledge and understanding of hope in general and expanded the human becoming school of thought.

  11. In Brief: Rita Colwell receives National Medal of Science

    NASA Astrophysics Data System (ADS)

    Kumar, Mohi

    2007-07-01

    Rita Colwell, director of the U.S. National Science Foundation from 1998 to 2004, was awarded a U.S. National Medal of Science in a White House ceremony on 27 July 2007. Colwell, currently a professor of microbiology and biotechnology at the University of Maryland at College Park and a professor at Johns Hopkins University Bloomberg School of Public Health, received the award for her research on global infectious diseases and marine microbes, specifically the bacterium that causes pandemic cholera. The National Medal of Science is the United States' highest honor for scientific achievement. Colwell currently serves on AGU's development board.

  12. 75 FR 22770 - Gary E. Hall and Rita Hall; Notice of Availability of Environmental Assessment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 13652-000-Montana] Gary E. Hall and Rita Hall; Notice of Availability of Environmental Assessment April 22, 2010. In accordance with the National Environmental Policy Act of 1969, as amended, and the Federal Energy Regulatory...

  13. Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation.

    PubMed

    Ma, Teng; Yamada, Shumpei; Ichwan, Solachuddin J A; Iseki, Sachiko; Ohtani, Kiyoshi; Otsu, Megumi; Ikeda, Masa-Aki

    2012-01-20

    The p53 tumor suppressor protein plays key roles in protecting cells from tumorigenesis. Phosphorylation of p53 at Ser46 (p53Ser46) is considered to be a crucial modification regulating p53-mediated apoptosis. Because the activity of p53 is impaired in most human cancers, restoration of wild-type p53 (wt-p53) function by its gene transfer or by p53-reactivating small molecules has been extensively investigated. The p53-reactivating compounds Nutlin-3 and RITA activate p53 in the absence of genotoxic stress by antagonizing the action of its negative regulator Mdm2. Although controversial, Nutlin-3 was shown to induce p53-mediated apoptosis in a manner independent of p53 phosphorylation. Recently, RITA was shown to induce apoptosis by promoting p53Ser46 phosphorylation. Here we examined whether Nutlin-3 or RITA can overcome resistance to p53-mediated apoptosis in p53-resistant tumor cell lines lacking the ability to phosphorylate p53Ser46. We show that Nutlin-3 did not rescue the apoptotic defect of a Ser46 phosphorylation-defective p53 mutant in p53-sensitive tumor cells, and that RITA neither restored p53Ser46 phosphorylation nor induced apoptosis in p53Ser46 phosphorylation-deficient cells retaining wt-p53. Furthermore, treatment with Nutlin-3 or RITA together with adenoviral p53 gene transfer also failed to induce apoptosis in p53Ser46 phosphorylation-deficient cells either expressing or lacking wt-p53. These results indicate that neither Nutlin-3 nor RITA in able to induce p53-mediated apoptosis in the absence of p53Ser46 phosphorylation. Thus, the dysregulation of this phosphorylation in tumor cells may be a critical factor that limits the efficacy of these p53-based cancer therapies. Copyright © 2011 Elsevier Inc. All rights reserved.

  14. RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53abnormal myeloma cells independently of the p53 pathway.

    PubMed

    Surget, Sylvanie; Descamps, Géraldine; Brosseau, Carole; Normant, Vincent; Maïga, Sophie; Gomez-Bougie, Patricia; Gouy-Colin, Nadège; Godon, Catherine; Béné, Marie C; Moreau, Philippe; Le Gouill, Steven; Amiot, Martine; Pellat-Deceunynck, Catherine

    2014-06-14

    The aim of this study was to evaluate the efficacy of the p53-reactivating drugs RITA and nutlin3a in killing myeloma cells. A large cohort of myeloma cell lines (n = 32) and primary cells (n = 21) was used for this study. This cohort contained cell lines with various TP53 statuses and primary cells with various incidences of deletion of chromosome 17. Apoptosis was evaluated using flow cytometry with Apo2.7 staining of the cell lines or via the loss of the myeloma-specific marker CD138 in primary cells. Apoptosis was further confirmed by the appearance of a subG1 peak and the activation of caspases 3 and 9. Activation of the p53 pathway was monitored using immunoblotting via the expression of the p53 target genes p21, Noxa, Bax and DR5. The involvement of p53 was further studied in 4 different p53-silenced cell lines. Both drugs induced the apoptosis of myeloma cells. The apoptosis that was induced by RITA was not related to the TP53 status of the cell lines or the del17p status of the primary samples (p = 0.52 and p = 0.80, respectively), and RITA did not commonly increase the expression level of p53 or p53 targets (Noxa, p21, Bax or DR5) in sensitive cells. Moreover, silencing of p53 in two TP53(mutated) cell lines failed to inhibit apoptosis that was induced by RITA, which confirmed that RITA-induced apoptosis in myeloma cells was p53 independent. In contrast, apoptosis induced by nutlin3a was directly linked to the TP53 status of the cell lines and primary samples (p < 0.001 and p = 0.034, respectively) and nutlin3a increased the level of p53 and p53 targets in a p53-dependent manner. Finally, we showed that a nutlin3a-induced DR5 increase (≥ 1.2-fold increase) was a specific and sensitive marker (p < 0.001) for a weak incidence of 17p deletion within the samples (≤ 19%). These data show that RITA, in contrast to nutlin3a, effectively induced apoptosis in a subset of MM cells independently of p53. The findings and could be of interest for patients with a

  15. RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53abnormal myeloma cells independently of the p53 pathway

    PubMed Central

    2014-01-01

    Background The aim of this study was to evaluate the efficacy of the p53-reactivating drugs RITA and nutlin3a in killing myeloma cells. Methods A large cohort of myeloma cell lines (n = 32) and primary cells (n = 21) was used for this study. This cohort contained cell lines with various TP53 statuses and primary cells with various incidences of deletion of chromosome 17. Apoptosis was evaluated using flow cytometry with Apo2.7 staining of the cell lines or via the loss of the myeloma-specific marker CD138 in primary cells. Apoptosis was further confirmed by the appearance of a subG1 peak and the activation of caspases 3 and 9. Activation of the p53 pathway was monitored using immunoblotting via the expression of the p53 target genes p21, Noxa, Bax and DR5. The involvement of p53 was further studied in 4 different p53-silenced cell lines. Results Both drugs induced the apoptosis of myeloma cells. The apoptosis that was induced by RITA was not related to the TP53 status of the cell lines or the del17p status of the primary samples (p = 0.52 and p = 0.80, respectively), and RITA did not commonly increase the expression level of p53 or p53 targets (Noxa, p21, Bax or DR5) in sensitive cells. Moreover, silencing of p53 in two TP53mutated cell lines failed to inhibit apoptosis that was induced by RITA, which confirmed that RITA-induced apoptosis in myeloma cells was p53 independent. In contrast, apoptosis induced by nutlin3a was directly linked to the TP53 status of the cell lines and primary samples (p < 0.001 and p = 0.034, respectively) and nutlin3a increased the level of p53 and p53 targets in a p53-dependent manner. Finally, we showed that a nutlin3a-induced DR5 increase (≥1.2-fold increase) was a specific and sensitive marker (p < 0.001) for a weak incidence of 17p deletion within the samples (≤19%). Conclusion These data show that RITA, in contrast to nutlin3a, effectively induced apoptosis in a subset of MM cells independently of p53. The findings and could be

  16. Vascular plants and a brief history of the Kiowa and Rita Blanca National Grasslands

    Treesearch

    Donald L. Hazlett; Michael H. Schiebout; Paulette L. Ford

    2009-01-01

    Administered by the USDA Forest Service, the Kiowa and Rita Blanca National Grasslands occupy 230,000 acres of public land extending from northeastern New Mexico into the panhandles of Oklahoma and Texas. A mosaic of topographic features including canyons, plateaus, rolling grasslands and outcrops supports a diverse flora. Eight hundred twenty six (826) species of...

  17. saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.

    PubMed

    Portnoy, Victoria; Lin, Szu Hua Sharon; Li, Kathy H; Burlingame, Alma; Hu, Zheng-Hui; Li, Hao; Li, Long-Cheng

    2016-03-01

    Small activating RNAs (saRNAs) targeting specific promoter regions are able to stimulate gene expression at the transcriptional level, a phenomenon known as RNA activation (RNAa). It is known that RNAa depends on Ago2 and is associated with epigenetic changes at the target promoters. However, the precise molecular mechanism of RNAa remains elusive. Using human CDKN1A (p21) as a model gene, we characterized the molecular nature of RNAa. We show that saRNAs guide Ago2 to and associate with target promoters. saRNA-loaded Ago2 facilitates the assembly of an RNA-induced transcriptional activation (RITA) complex, which, in addition to saRNA-Ago2 complex, includes RHA and CTR9, the latter being a component of the PAF1 complex. RITA interacts with RNA polymerase II to stimulate transcription initiation and productive elongation, accompanied by monoubiquitination of histone 2B. Our results establish the existence of a cellular RNA-guided genome-targeting and transcriptional activation mechanism and provide important new mechanistic insights into the RNAa process.

  18. "Making Lemonade from Lemons:" Early Childhood Teacher Educators' Programmatic Responses to Hurricanes Katrina and Rita

    ERIC Educational Resources Information Center

    DiCarlo, Cynthia F.; Burts, Diane C.; Buchanan, Teresa K.; Aghayan, Carol; Benedict, Joan

    2007-01-01

    This article describes how early childhood teacher education faculty at one university responded in the aftermath of hurricanes Katrina and Rita and used the disaster to enhance their undergraduate and graduate programs. They explain how they modeled developmentally appropriate practices while responding to community needs. Four companion articles…

  19. Archive and laboratory embedded in the landscape: Future of the Santa Rita Experimental Range

    Treesearch

    Thomas E. Sheridan

    2003-01-01

    The Santa Rita Experimental Range (SRER) is both an archive of past ecological research and a laboratory for continuing research embedded in the southern Arizona landscape. The scientific questions being asked there have changed over the last 100 years, but SRER with its monitoring stations and its legacy of repeat photography still offers a unique opportunity to study...

  20. Rangeland livestock production: Developing the concept of sustainability on the Santa Rita Experimental Range

    Treesearch

    George B. Ruyle

    2003-01-01

    The Santa Rita Experimental Range (SRER) was established in 1903 at the behest of concerned stockmen and researchers as the first facility in the United States set aside to study range livestock production. At the time, severe overgrazing of the public domain had seriously reduced carrying capacities of Southwestern rangelands. Researchers on the SRER developed and...

  1. Katrina and Rita were lit up with lightning

    NASA Astrophysics Data System (ADS)

    Shao, X.-M.; Harlin, J.; Stock, M.; Stanley, M.; Regan, A.; Wiens, K.; Hamlin, T.; Pongratz, M.; Suszcynsky, D.; Light, T.

    Hurricanes generally produce very little lightning activity compared to other noncyclonic storms, and lightning is especially sparse in the eye wall and inner regions within tens of kilometers surrounding the eye [Molinari et al., 1994, 1999]. (The eye wall is the wall of clouds that encircles the eye of the hurricane.) Lightning can sometimes be detected in the outer, spiral rainbands, but the lightning occurrence rate varies significantly from hurricane to hurricane as well as within an individual hurricane's lifetime.Hurricanes Katrina and Rita hit the U.S. Gulf coasts of Louisiana, Mississippi, and Texas, and their distinctions were not just limited to their tremendous intensity and damage caused. They also differed from typical hurricanes in their lightning production rate.

  2. The effect of proximity to hurricanes Katrina and Rita on subsequent hurricane outlook and optimistic bias.

    PubMed

    Trumbo, Craig; Lueck, Michelle; Marlatt, Holly; Peek, Lori

    2011-12-01

    This study evaluated how individuals living on the Gulf Coast perceived hurricane risk after Hurricanes Katrina and Rita. It was hypothesized that hurricane outlook and optimistic bias for hurricane risk would be associated positively with distance from the Katrina-Rita landfall (more optimism at greater distance), controlling for historically based hurricane risk and county population density, demographics, individual hurricane experience, and dispositional optimism. Data were collected in January 2006 through a mail survey sent to 1,375 households in 41 counties on the coast (n = 824, 60% response). The analysis used hierarchal regression to test hypotheses. Hurricane history and population density had no effect on outlook; individuals who were male, older, and with higher household incomes were associated with lower risk perception; individual hurricane experience and personal impacts from Katrina and Rita predicted greater risk perception; greater dispositional optimism predicted more optimistic outlook; distance had a small effect but predicted less optimistic outlook at greater distance (model R(2) = 0.21). The model for optimistic bias had fewer effects: age and community tenure were significant; dispositional optimism had a positive effect on optimistic bias; distance variables were not significant (model R(2) = 0.05). The study shows that an existing measure of hurricane outlook has utility, hurricane outlook appears to be a unique concept from hurricane optimistic bias, and proximity has at most small effects. Future extension of this research will include improved conceptualization and measurement of hurricane risk perception and will bring to focus several concepts involving risk communication. © 2011 Society for Risk Analysis.

  3. Positive Traits versus Previous Trauma: Racially Different Correlates with PTSD Symptoms among Hurricane Katrina-Rita Volunteers

    ERIC Educational Resources Information Center

    Ai, Amy L.; Plummer, Carol; Kanno, Hanae; Heo, Grace; Appel, Hoa B.; Simon, Cassandra E.; Spigner, Clarence

    2011-01-01

    This study compared risks and protective factors for acquiring symptoms of posttraumatic stress disorder (PTSD) between African-American (n = 299) and European-American (n = 206) student volunteers 3 months after Hurricanes Katrina and Rita (H-KR). Respondents retrospectively provided information on peritraumatic emotional reactions and previous…

  4. Transformative experiences for Hurricanes Katrina and Rita disaster volunteers.

    PubMed

    Clukey, Lory

    2010-07-01

    The massive destruction caused by Hurricanes Katrina and Rita in 2005 provided an opportunity for many volunteers to be involved with disaster relief work. Exposure to devastation and personal trauma can have long-lasting and sometimes detrimental effects on people providing help. This qualitative study explored the experience of volunteer relief workers who provided disaster relief services after the hurricanes. Three major themes emerged: emotional reactions that included feelings of shock, fatigue, anger and grief as well as sleep disturbances; frustration with leadership; and life-changing personal transformation. Stress reactions were noted but appeared to be mitigated by feelings of compassion for the victims and personal satisfaction in being able to provide assistance. Suggestions are provided for further research.

  5. Missed by the Mass Media: The Houma, Pointe-au-Chien, and Hurricanes Katrina and Rita

    ERIC Educational Resources Information Center

    Collins, Robert Keith

    2008-01-01

    This case study investigates the media discourse from Houma and Pointe-au-Chien tribal leaders in Louisiana on their experiences with Hurricanes Katrina and Rita. One section briefly engages the discourse as discernable from the reports found in Native American and non-Native American news media. Included is a brief yet close examination of these…

  6. Children's Reactions to Katrina and Rita: A Ph.D. Student's Reflection after Observing His Own Children

    ERIC Educational Resources Information Center

    Durham, R. Sean

    2007-01-01

    A graduate student in early childhood education discusses observations of his children during and after Hurricanes Rita and Katrina struck the Gulf Coast. He relates his use of responsive parenting and provides examples of his children's learning and play that emerged after the storms. He reflects upon how aspects of developmentally appropriate…

  7. Dissolved and colloidal trace elements in the Mississippi River delta outflow after Hurricanes Katrina and Rita

    NASA Astrophysics Data System (ADS)

    Shim, Moo-Joon; Swarzenski, Peter W.; Shiller, Alan M.

    2012-07-01

    The Mississippi River delta outflow region is periodically disturbed by tropical weather systems including major hurricanes, which can terminate seasonal bottom water hypoxia and cause the resuspension of shelf bottom sediments which could result in the injection of trace elements into the water column. In the summer of 2005, Hurricanes Katrina and Rita passed over the Louisiana Shelf within a month of each other. Three weeks after Rita, we collected water samples in the Mississippi River delta outflow, examining the distributions of trace elements to study the effect of Hurricanes Katrina and Rita. We observed limited stratification on the shelf and bottom waters that were no longer hypoxic. This resulted, for instance, in bottom water dissolved Mn being lower than is typically observed during hypoxia, but with concentrations still compatible with Mn-O2 trends previously reported. Interestingly, for no element were we able to identify an obvious effect of sediment resuspension on its distribution. In general, elemental distributions were compatible with previous observations in the Mississippi outflow system. Co and Re, which have not been reported for this system previously, showed behavior consistent with other systems: input for Co likely from desorption and conservative mixing for Re. For Cs, an element for which there is little information regarding its estuarine behavior, conservative mixing was also observed. Our filtration method, which allowed us to distinguish the dissolved (<0.02 μm) from colloidal (0.02-0.45 μm) phase, revealed significant colloidal fractions for Fe and Zn, only. For Fe, the colloidal phase was the dominant fraction and was rapidly removed at low salinity. Dissolved Fe, in contrast, persisted out to mid-salinities, being removed in a similar fashion to nitrate. This ability to distinguish the smaller Fe (likely dominantly organically complexed) from larger colloidal suspensates may be useful in better interpreting the bioavailablity

  8. Restoration of the Mississippi Delta: Lessons from Hurricanes Katrina and Rita

    NASA Astrophysics Data System (ADS)

    Day, John W.; Boesch, Donald F.; Clairain, Ellis J.; Kemp, G. Paul; Laska, Shirley B.; Mitsch, William J.; Orth, Kenneth; Mashriqui, Hassan; Reed, Denise J.; Shabman, Leonard; Simenstad, Charles A.; Streever, Bill J.; Twilley, Robert R.; Watson, Chester C.; Wells, John T.; Whigham, Dennis F.

    2007-03-01

    Hurricanes Katrina and Rita showed the vulnerability of coastal communities and how human activities that caused deterioration of the Mississippi Deltaic Plain (MDP) exacerbated this vulnerability. The MDP formed by dynamic interactions between river and coast at various temporal and spatial scales, and human activity has reduced these interactions at all scales. Restoration efforts aim to re-establish this dynamic interaction, with emphasis on reconnecting the river to the deltaic plain. Science must guide MDP restoration, which will provide insights into delta restoration elsewhere and generally into coasts facing climate change in times of resource scarcity.

  9. Impact of hurricanes katrina and rita on the anesthesiology workforce.

    PubMed

    Hutson, Larry R; Vega, Jorge; Schubert, Armin

    2011-01-01

    Hurricanes Katrina and Rita impacted a large portion of the medical community in Louisiana. We attempt to determine their impact on the anesthesiology workforce in Louisiana. In May 2006, a survey was mailed to 368 Louisiana anesthesiologists, collecting demographic data, retirement plans, impact of Hurricanes Katrina and Rita, position vacancies, practice conditions, and the general state of healthcare in their area. All 3 anesthesiology residency programs in the state were contacted regarding their recent graduates. The 2010 RAND survey of the anesthesiology workforce was reviewed with respect to findings relevant to the state and region. One hundred seventy surveys were returned, yielding a 46.2% response rate. Among the respondents, 13.9% intended to retire within 5 years and another 24% in 5 to 10 years. Since 2005, 63.9% had seen an increase in their daily caseload, 46.9% saw an increase in work hours, and 36.8% stated that their practices were trying to hire new anesthesiologists and were having difficulty filling these positions. Since 2005, the number of anesthesiology residents in Louisiana had declined by almost 50%, and the number of graduates remaining to practice in Louisiana had decreased by 43% from 7 to 4 annually. Our 2006 survey provided qualitative evidence for a shortage of anesthesiologists in the state of Louisiana after the natural disasters in 2005 that was likely to worsen as residency output plummeted, fewer residents stayed in the state, and projected retirement increased. The regional data from the RAND survey a year later confirmed the impressions from our survey, with an estimate of an anesthesiologist shortage as high as 39% of the workforce. State membership surveys may serve as accurate barometers in the wake of major environmental upheavals affecting regional anesthesiology workforce conditions.

  10. The monochromatic imaging mode of a RITA-type neutron spectrometer

    NASA Astrophysics Data System (ADS)

    Bahl, C. R. H.; Andersen, P.; Klausen, S. N.; Lefmann, K.

    2004-12-01

    The imaging monochromatic mode of a neutron spectrometer with a multi-bladed RITA analyser system is so far unexplored. We present analytical calculations that define the mode. It is shown that the mode can be realised for PG (0 0 2) analyser crystals, from incident energies of about 3.2 meV and up, allowing the important cases of 3.7, 5.0 and 13.7 meV. Due to beam divergence, the neutron rays from neighbouring analyser blades are found to overlap slightly. Hence, the optimal use of the monochromatic imaging mode would be found by employing an adjustable radial collimator to limit the spread of the ray from each analyser blade.

  11. Mapping hurricane rita inland storm tide

    USGS Publications Warehouse

    Berenbrock, C.; Mason, R.R.; Blanchard, S.F.

    2009-01-01

    Flood-inundation data are most useful for decision makers when presented in the context of maps of affected communities and (or) areas. But because the data are scarce and rarely cover the full extent of the flooding, interpolation and extrapolation of the information are needed. Many geographic information systems provide various interpolation tools, but these tools often ignore the effects of the topographic and hydraulic features that influence flooding. A barrier mapping method was developed to improve maps of storm tide produced by Hurricane Rita. Maps were developed for the maximum storm tide and at 3-h intervals from midnight (00:00 hours) through noon (12:00 hours) on 24 September 2005. The improved maps depict storm-tide elevations and the extent of flooding. The extent of storm-tide inundation from the improved maximum storm-tide map was compared with the extent of flood inundation from a map prepared by the Federal Emergency Management Agency (FEMA). The boundaries from these two maps generally compared quite well especially along the Calcasieu River. Also a cross-section profile that parallels the Louisiana coast was developed from the maximum storm-tide map and included FEMA high-water marks. ?? 2009 Blackwell Publishing Ltd.

  12. Mapping Hurricane Rita inland storm tide

    USGS Publications Warehouse

    Berenbrock, Charles; Mason, Jr., Robert R.; Blanchard, Stephen F.; Simonovic, Slobodan P.

    2009-01-01

    Flood-inundation data are most useful for decision makers when presented in the context of maps of effected communities and (or) areas. But because the data are scarce and rarely cover the full extent of the flooding, interpolation and extrapolation of the information are needed. Many geographic information systems (GIS) provide various interpolation tools, but these tools often ignore the effects of the topographic and hydraulic features that influence flooding. A barrier mapping method was developed to improve maps of storm tide produced by Hurricane Rita. Maps were developed for the maximum storm tide and at 3-hour intervals from midnight (0000 hour) through noon (1200 hour) on September 24, 2005. The improved maps depict storm-tide elevations and the extent of flooding. The extent of storm-tide inundation from the improved maximum storm-tide map was compared to the extent of flood-inundation from a map prepared by the Federal Emergency Management Agency (FEMA). The boundaries from these two maps generally compared quite well especially along the Calcasieu River. Also a cross-section profile that parallels the Louisiana coast was developed from the maximum storm-tide map and included FEMA high-water marks.

  13. EMC tests on the RITA Ion Propulsion Assembly for the ARTEMIS satellite

    NASA Astrophysics Data System (ADS)

    Mueller, H.; Kukies, R.; Bassner, H.

    1992-07-01

    Objectives and results of EMC tests performed on the RITA Ion Propulsion Assembly to demonstrate its compatibility with the requirements of ARTEMIS are discussed. The tested configuration included the RIT 10 thruster, neutralizer, RF generator, power supply and control unit, and electrical ground support equipment. Test results show that the RIT 10 thruster fulfils the EMC requirements for radiated emission in the critical frequency ranges (L/S/KU bands). The emitted E- and H-fields are not expected to disturb the satellite electronics, and no special shielding or other measures to protect the antennas are needed.

  14. Mapping and Visualization of Storm-Surge Dynamics for Hurricane Katrina and Hurricane Rita

    USGS Publications Warehouse

    Gesch, Dean B.

    2009-01-01

    The damages caused by the storm surges from Hurricane Katrina and Hurricane Rita were significant and occurred over broad areas. Storm-surge maps are among the most useful geospatial datasets for hurricane recovery, impact assessments, and mitigation planning for future storms. Surveyed high-water marks were used to generate a maximum storm-surge surface for Hurricane Katrina extending from eastern Louisiana to Mobile Bay, Alabama. The interpolated surface was intersected with high-resolution lidar elevation data covering the study area to produce a highly detailed digital storm-surge inundation map. The storm-surge dataset and related data are available for display and query in a Web-based viewer application. A unique water-level dataset from a network of portable pressure sensors deployed in the days just prior to Hurricane Rita's landfall captured the hurricane's storm surge. The recorded sensor data provided water-level measurements with a very high temporal resolution at surveyed point locations. The resulting dataset was used to generate a time series of storm-surge surfaces that documents the surge dynamics in a new, spatially explicit way. The temporal information contained in the multiple storm-surge surfaces can be visualized in a number of ways to portray how the surge interacted with and was affected by land surface features. Spatially explicit storm-surge products can be useful for a variety of hurricane impact assessments, especially studies of wetland and land changes where knowledge of the extent and magnitude of storm-surge flooding is critical.

  15. Traumatic Loss and Natural Disaster: A Case Study of a School-Based Response to Hurricanes Katrina and Rita

    ERIC Educational Resources Information Center

    Clettenberg, Stacey; Gentry, Judy; Held, Matthew; Mock, Lou Ann

    2011-01-01

    This article tracks the trajectory and impact of Hurricanes Katrina and Rita on the communities of Houston/Harris County, Texas, USA, the schools, children, and families; along with the community partnerships that addressed the trauma and upheaval. Following the influx of individuals and families who were displaced by Hurricanes Katrina and Rita…

  16. Dissolved and colloidal trace elements in the Mississippi River Delta outflow after Hurricanes Katrina and Rita

    USGS Publications Warehouse

    Shim, Moo-Joon; Swarzenski, Peter W.; Shiller, Alan M.

    2012-01-01

    The Mississippi River delta outflow region is periodically disturbed by tropical weather systems including major hurricanes, which can terminate seasonal bottom water hypoxia and cause the resuspension of shelf bottom sediments which could result in the injection of trace elements into the water column. In the summer of 2005, Hurricanes Katrina and Rita passed over the Louisiana Shelf within a month of each other. Three weeks after Rita, we collected water samples in the Mississippi River delta outflow, examining the distributions of trace elements to study the effect of Hurricanes Katrina and Rita. We observed limited stratification on the shelf and bottom waters that were no longer hypoxic. This resulted, for instance, in bottom water dissolved Mn being lower than is typically observed during hypoxia, but with concentrations still compatible with Mn–O2 trends previously reported. Interestingly, for no element were we able to identify an obvious effect of sediment resuspension on its distribution. In general, elemental distributions were compatible with previous observations in the Mississippi outflow system. Co and Re, which have not been reported for this system previously, showed behavior consistent with other systems: input for Co likely from desorption and conservative mixing for Re. For Cs, an element for which there is little information regarding its estuarine behavior, conservative mixing was also observed. Our filtration method, which allowed us to distinguish the dissolved (<0.02 μm) from colloidal (0.02–0.45 μm) phase, revealed significant colloidal fractions for Fe and Zn, only. For Fe, the colloidal phase was the dominant fraction and was rapidly removed at low salinity. Dissolved Fe, in contrast, persisted out to mid-salinities, being removed in a similar fashion to nitrate. This ability to distinguish the smaller Fe (likely dominantly organically complexed) from larger colloidal suspensates may be useful in better interpreting the

  17. Satellite Images and Aerial Photographs of the Effects of Hurricanes Katrina and Rita on Coastal Louisiana

    USGS Publications Warehouse

    Barras, John A.

    2007-01-01

    Introduction Hurricane Katrina made landfall on the eastern coastline of Louisiana on August 29, 2005; Hurricane Rita made landfall on the western coastline of Louisiana on September 24, 2005. Comparison of Landsat Thematic Mapper (TM) satellite imagery acquired before and after the landfalls of Katrina and Rita and classified to identify land and water demonstrated that water area increased by 217 mi2 (562 km2) in coastal Louisiana as a result of the storms. Approximately 82 mi2 (212 km2) of new water areas were in areas primarily impacted by Hurricane Katrina (Mississippi River Delta basin, Breton Sound basin, Pontchartrain basin, and Pearl River basin), whereas 99 mi2 (256 km2) were in areas primarily impacted by Hurricane Rita (Calcasieu/Sabine basin, Mermentau basin, Teche/Vermilion basin, Atchafalaya basin, and Terrebonne basin). Barataria basin contained new water areas caused by both hurricanes, resulting in some 18 mi2 (46.6 km2) of new water areas. The fresh marsh and intermediate marsh communities' land areas decreased by 122 mi2 (316 km2) and 90 mi2 (233.1 km2), respectively, and the brackish marsh and saline marsh communities' land areas decreased by 33 mi2 (85.5 km2) and 28 mi2 (72.5 km2), respectively. These new water areas represent land losses caused by direct removal of wetlands. They also indicate transitory changes in water area caused by remnant flooding, removal of aquatic vegetation, scouring of marsh vegetation, and water-level variation attributed to normal tidal and meteorological variation between satellite images. Permanent losses cannot be estimated until several growing seasons have passed and the transitory impacts of the hurricanes are minimized. The purpose of this study was to provide preliminary information on water area changes in coastal Louisiana acquired shortly after the landfalls of both hurricanes (detectable with Landsat TM imagery) and to serve as a regional baseline for monitoring posthurricane wetland recovery. The land

  18. Initial management of hospital evacuations caused by Hurricane Rita: a systematic investigation.

    PubMed

    Downey, Erin L; Andress, Knox; Schultz, Carl H

    2013-06-01

    Hurricanes remain a major threat to hospitals throughout the world. The authors attempted to identify the planning areas that impact hospital management of evacuations and the challenges faced when sheltering-in-place. This observational, retrospective cohort study examined acute care institutions from one hospital system impacted by Hurricane Rita in 2005. Investigators used a standardized survey instrument and interview process, previously used in the hospital evacuation context, to examine hospitals' initial internal situational awareness and subsequent decision making that resulted in evacuation due to Hurricane Rita. Participants from each hospital included representatives from senior leadership and clinical and nonclinical staff that comprised the Incident Management Team (IMT). The main measured outcomes were responses to 95 questions contained in the survey. Seven of ten eligible hospitals participated in the study. All facilities evacuated the sickest patients first. The most significant factors prompting evacuation were the issuing of mandatory evacuation orders, storm dynamics (category, projected path, storm surge), and loss of regional communications. Hospitals that sheltered-in-place experienced staff shortages, interruptions to electrical power, and loss of water supplies. Three fully-evacuated institutions experienced understaffing of 40%-60%, and four hospitals sustained depressed staffing levels for over four weeks. Five hospitals lost electricity for a mean of 4.8 days (range .5-11 days). All facilities continued to receive patients to their Emergency Departments (EDs) while conducting their own evacuation. Hospital EDs should plan for continuous patient arrival during evacuation. Emergency Operation Plans (EOPs) that anticipate challenges associated with evacuation will help to maximize initial decision making and management during a crisis situation. Hospitals that shelter-in-place face critical shortages and must provide independent patient

  19. Mold exposure and health effects following hurricanes Katrina and Rita.

    PubMed

    Barbeau, Deborah N; Grimsley, L Faye; White, LuAnn E; El-Dahr, Jane M; Lichtveld, Maureen

    2010-01-01

    The extensive flooding in the aftermath of Hurricanes Katrina and Rita created conditions ideal for indoor mold growth, raising concerns about the possible adverse health effects associated with indoor mold exposure. Studies evaluating the levels of indoor and outdoor molds in the months following the hurricanes found high levels of mold growth. Homes with greater flood damage, especially those with >3 feet of indoor flooding, demonstrated higher levels of mold growth compared with homes with little or no flooding. Water intrusion due to roof damage was also associated with mold growth. However, no increase in the occurrence of adverse health outcomes has been observed in published reports to date. This article considers reasons why studies of mold exposure after the hurricane do not show a greater health impact.

  20. Hurricane Rita and the destruction of Holly Beach, Louisiana: Why the chenier plain is vulnerable to storms

    USGS Publications Warehouse

    Sallenger, A.H.; Wright, C.W.; Doran, K.; Guy, K.; Morgan, K.

    2009-01-01

    Hurricane Rita devastated gulf-front communities along the western Louisiana coast in 2005. LIDAR (light detection and ranging) topographic surveys and aerial photography collected before and after the storm showed the loss of every structure within the community of Holly Beach. Average shoreline change along western Louisiana's 140-km-long impacted shore was -23.3 ?? 30.1 m of erosion, although shoreline change in Holly Beach was substantially less, and erosion was not pervasive where the structures were lost. Before the storm, peak elevations of the dunes, or berms in the absence of dunes, along the impacted shore averaged 1.6 m. The storm surge, which reached 3.5 m just east of Holly Beach, completely inundated the beach systems along the impacted western Louisiana shore. The high surge potential and low land elevations make this coast extremely vulnerable to hurricanes. In fact, most of the western Louisiana shore impacted by Rita will be completely inundated by the storm surge of a worst-case Saffi r-Simpson category 1 hurricane. All of this shore will be inundated by worst-case category 2-5 storms. ?? 2009 The Geological Society of America.

  1. San Antonio Mental Health Disaster Consortium: Hurricanes Katrina and Rita, a personal perspective.

    PubMed

    Marshall, Margaret Cole

    2007-02-01

    This is the personal perspective of the author's experience during Hurricanes Katrina and Rita. As a member of a professional mental health volunteer organization, this chronicles 3 months' experience in the local shelters. Difficulties with organizational support and structure hampered the effectiveness and functioning of this volunteer organization in the shelters. To identify lessons learned from this experience. It is essential to identify where each mental health volunteer group fits into the organizational structure and what the role of each is. Volunteers need to be scheduled and relieved at regular intervals to rest so as to prevent stress reactions.

  2. Inelastic neutron scattering experiments with the monochromatic imaging mode of the RITA-II spectrometer

    NASA Astrophysics Data System (ADS)

    Bahl, C. R. H.; Lefmann, K.; Abrahamsen, A. B.; Rønnow, H. M.; Saxild, F.; Jensen, T. B. S.; Udby, L.; Andersen, N. H.; Christensen, N. B.; Jakobsen, H. S.; Larsen, T.; Häfliger, P. S.; Streule, S.; Niedermayer, Ch.

    2006-05-01

    Recently a monochromatic multiple data taking mode has been demonstrated for diffraction experiments using a RITA type cold neutron spectrometer with a multi-bladed analyser and a position-sensitive detector. Here, we show how this mode can be used in combination with a flexible radial collimator to perform real inelastic neutron scattering experiments. We present the results from inelastic powder, single crystal dispersion and single crystal constant energy mapping experiments. The advantages and complications of performing these experiments are discussed along with a comparison between the imaging mode and the traditional monochromatic focussing mode.

  3. Mineral, Energy, and Fertilizer Resources of the North Coast of Peru: Perspective from the Santa Rita B Archaeological Site

    USGS Publications Warehouse

    Brooks, William E.; Kent, Jonathan D.; Willett, Jason C.

    2004-01-01

    The Santa Rita B archaeological site is in the Chao Valley, approximately 65 km southeast of Trujillo, northern Peru. Location of Santa Rita B at the emergence of several drainages from the Andean cordillera is an important factor in the almost continuous occupation of the site over the past 3,000 years. Mineral resources are abundant throughout the Andes; however, the north coast of Peru was an important center for pre-Columbian mining, metallurgy, and craftsmanship. Success of the Chavin, Moche, Chimu, and other north coast cultures is directly related to the availability and exploitation of mineral and energy resources that include: gold (?silver), as electrum, mainly from placers, and copper from local oxide and carbonate occurrences and from sulfides related to copper porphyry occurrences in the cordillera. An alloy of these three metals is referred to as tumbaga, which is the primary material for Andean metalcraft. Anthracite was used for mirrors by north coast cultures and is available near Rio Chicama, Rio Santa, and east of Santa Rita B. These outcrops are a part of the Alto Chicama, Peru's largest coalfield, which extends from Rio Chicama, in the north, for 200 km southward to Rio Santa. Charcoal from the algorrobo tree and llama dung are considered to be the common pre-Columbian energy sources for cooking and metalwork; however, availability and the higher heat content of anthracite indicate that it was used in metallurgical applications. Bitumen is available from petroleum seeps near Talara, north of the study area, and may have been used as glue or as cement. Hematite, goethite, limonite, and manganese oxides from clay-altered volcanic rock may have provided color and material for ceramics. Guano from the Islas Gua?apes, Chinchas, and Ballestas was used as fertilizer for cotton and other crops.

  4. Mental Health, Substance Use, and Adaptive Coping among Social Work Students in the Aftermath of Hurricanes Katrina and Rita

    ERIC Educational Resources Information Center

    Lemieux, Catherine M.; Plummer, Carol A.; Richardson, Roslyn; Simon, Cassandra E.; Ai, Amy L.

    2010-01-01

    The current study examined mental health symptomology, substance use, and adaptive coping among 416 social work students following Hurricanes Katrina and Rita. Among participants, 47% scored at or above the clinical level for depression, with 6% of students showing clinical PTSD-like symptoms, and 16.9% reporting substance use. Two thirds (66.9%)…

  5. Rising Above the Water: New Orleans Implements Energy Efficiency and Sustainability Practices Following Hurricanes Katrina and Rita (Fact Sheet)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This fact sheet describes the technical assistance that the U.S. Department of Energy, through its National Renewable Energy Laboratory, provided to New Orleans, Louisiana, which helped the city incorporate energy efficiency into its rebuilding efforts for K-12 schools and homes following Hurricanes Katrina and Rita. NREL also provided support and analysis on energy policy efforts.

  6. When the Saints Come Marching In. Effects of Hurricanes Katrina and Rita on Student Evacuees. NBER Working Paper No. 14385

    ERIC Educational Resources Information Center

    Sacerdote, Bruce

    2008-01-01

    I examine academic performance and college going for public school students affected by Hurricanes Katrina and Rita. Students who are forced to switch schools due to the hurricanes experience sharp declines in test scores in the first year following the hurricane. However, by the second and third years after the disaster, Katrina evacuees…

  7. Monitoring Inland Storm Surge and Flooding from Hurricane Rita

    USGS Publications Warehouse

    McGee, Benton D.; Tollett, Roland W.; Mason, Jr., Robert R.

    2006-01-01

    Pressure transducers (sensors) and high-water marks were used to document the inland water levels related to storm surge generated by Hurricane Rita in southwestern Louisiana and southeastern Texas. On September 22-23, 2005, an experimental monitoring network of sensors was deployed at 33 sites over an area of about 4,000 square miles to record the timing, extent, and magnitude of inland hurricane storm surge and coastal flooding. Sensors were programmed to record date and time, temperature, and barometric or water pressure. Water pressure was corrected for changes in barometric pressure and salinity. Elevation surveys using global-positioning systems and differential levels were used to relate all storm-surge water-level data, reference marks, benchmarks, sensor measuring points, and high-water marks to the North American Vertical Datum of 1988 (NAVD 88). The resulting data indicated that storm-surge water levels over 14 feet above NAVD 88 occurred at three locations, and rates of water-level rise greater than 5 feet per hour occurred at three locations near the Louisiana coast.

  8. RITA--Registry of Industrial Toxicology Animal data: the application of historical control data for Leydig cell tumors in rats.

    PubMed

    Nolte, Thomas; Rittinghausen, Susanne; Kellner, Rupert; Karbe, Eberhard; Kittel, Birgit; Rinke, Matthias; Deschl, Ulrich

    2011-11-01

    Historical data for Leydig cell tumors from untreated or vehicle treated rats from carcinogenicity studies collected in the RITA database are presented. Examples are given for analyses of these data for dependency on variables considered to be of possible influence on the spontaneous incidence of Leydig cell tumors. In the 7453 male rats available for analysis, only one case of a Leydig cell carcinoma was identified. The incidence of Leydig cell adenomas differed markedly between strains. High incidences of close to 100% have been found in F344 rats, while the mean incidence was 4.2% in Sprague-Dawley rats and 13.7% in Wistar rats. Incidences in Wistar rats were highly variable, primarily caused by different sources of animals. Mean incidences per breeder varied from 2.8 to 39.9%. Analyses for the dependency on further parameters have been performed in Wistar rats. In breeders G and I, the Leydig cell tumor incidence decreased over the observation period and with increasing mean terminal body weight. The incidence of Leydig cell tumors increased with mean age at necropsy and was higher in studies with dietary admixture compared to gavage studies. These parameters had no effect on Leydig cell tumor incidence in breeders A and B. Animals from almost all breeders had a considerably higher mean age at necropsy when bearing a Leydig cell adenoma than animals without a Leydig cell adenoma. Studies with longitudinal trimming of the testes had a higher incidence than studies with transverse trimming. The observed dependencies and breeder differences are discussed and explanations are given. Consequences for the use of historical control data are outlined. With the retrospective analyses presented here we were able to confirm the published features of Leydig cell adenomas and carcinomas. This indicates that the RITA database is a valuable tool for analyses of tumors for their biological features. Furthermore, it demonstrates that the RITA database is highly beneficial for

  9. Multi-proxy Characterization of Two Recent Storm Deposits Attributed to Hurricanes Rita and Ike in the Chenier Plain of Southwestern Louisiana

    NASA Astrophysics Data System (ADS)

    Yao, Q.; Liu, K. B.; Ryu, J.

    2017-12-01

    The Chenier Plain in southwestern Louisiana owes its origin to dynamic depositional processes that are dominated by delta-switching of the Mississippi River to the east, while frequent hurricane activities also play an important role in its geomorphology and sedimentary history. However, despite several studies in the literature, the sediment-stratigraphic characteristics of recent or historic hurricane deposits are still not well documented from the Chenier Plain. In 2005 and 2008, Hurricane Rita (category 3) and Ike (category 2) made landfall on the coasts of Louisiana and Texas. Remote sensing images confirm that the Rockefeller Wildlife Refuge, located at the east end of the Louisiana Chenier Plain, was heavily impacted by both hurricanes. We analyzed the lithology and chemical stratigraphy of three 30 cm sediment monoliths (ROC-1, ROC-2, and ROC-3) recovered from a coastal saltmarsh in the Rockefeller Wildlife Refuge to identify the event deposits attributed to these two storms. Each monolith contains 2 distinct light-colored clastic sediment layers imbedded in brown organic clay. The loss-on-ignition and X-ray fluorescence results show that the hurricane layers have increased contents of Ca, Sr, Zr, and carbonates and decreased contents of water and organics. Surprisingly, despite its greater intensity and more severe impacts, Hurricane Rita left a much thinner storm deposit than did Hurricane Ike in all monoliths. Satellite data reveal that Hurricane Rita caused significant coastal erosion and shoreline recession, rendering the sampling sites much closer to the beach and ocean and therefore more prone to storm surges and overwash deposition than when Hurricane Ike struck three years later. Our results suggest that site-to-sea distance, which affects a study site's paleotempestological sensitivity, can play a bigger role in affecting the thicknesses of storm deposits than the intensity of the hurricane.

  10. Drug Resistance to Inhibitors of the Human Double Minute-2 E3 Ligase is Mediated by Point Mutations of p53, but can be Overcome with the p53 Targeting Agent RITA

    PubMed Central

    Jones, Richard J.; Bjorklund, Chad C.; Baladandayuthapani, Veerabhadran; Kuhn, Deborah J.; Orlowski, Robert Z.

    2012-01-01

    The human double minute (HDM)-2 E3 ubiquitin ligase plays a key role in p53 turnover, and has been validated pre-clinically as a target in multiple myeloma (MM) and mantle cell lymphoma (MCL). HDM-2 inhibitors are entering clinical trials, and we therefore sought to understand potential mechanisms of resistance in lymphoid models. Wild-type p53 H929 MM and Granta-519 MCL cells resistant to MI-63 or Nutlin were generated by exposing them to increasing drug concentrations. MI-63-resistant H929 and Granta-519 cells were resistant to Nutlin, while Nutlin-resistant cells displayed cross-resistance to MI-63. These cells also showed cross-resistance to bortezomib, doxorubicin, cisplatin, and melphalan, but remained sensitive to the small molecule inhibitor RITA. HDM-2 inhibitor-resistant cells harbored increased p53 levels, but neither genotoxic nor non-genotoxic approaches to activate p53 induced HDM-2 or p21. Resequencing revealed wild-type HDM-2, but mutations were found in the p53 DNA binding and dimerization domains. In resistant cells, RITA induced a G2/M arrest, up-regulation of p53 targets HDM-2, PUMA, and NOXA, and PARP cleavage. Combination regimens with RITA and MI-63 resulted in enhanced cell death compared to RITA alone. These findings support the possibility that p53 mutation could be a primary mechanism of acquired resistance to HDM-2 inhibitors in MCL and MM. Furthermore, they suggest that simultaneous restoration of p53 function and HDM-2 inhibition is a rational strategy for clinical translation. PMID:22933706

  11. Santa Rita Experimental Range: 100 years (1903 to 2003) of accomplishments and contributions; conference proceedings; 2003 October 30-November 1; Tucson, AZ

    Treesearch

    Mitchel P. McClaran; Peter F. Ffolliott; Carleton B. Edminster

    2003-01-01

    The purpose of this conference was to celebrate the 100 years of accomplishments and contributions of the Santa Rita Experimental Range, the longest continuously operating research area dedicated to the sustainable management of North American rangelands. The conference consisted of one-and-a-half days of invited synthesis papers and contributed poster presentations...

  12. Satellite Assessment of Bio-Optical Properties of Northern Gulf of Mexico Coastal Waters Following Hurricanes Katrina and Rita.

    PubMed

    Lohrenz, Steven E; Cai, Wei-Jun; Chen, Xiaogang; Tuel, Merritt

    2008-07-10

    The impacts of major tropical storms events on coastal waters include sediment resuspension, intense water column mixing, and increased delivery of terrestrial materials into coastal waters. We examined satellite imagery acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS) ocean color sensor aboard the Aqua spacecraft following two major hurricane events: Hurricane Katrina, which made landfall on 29 August 2005, and Hurricane Rita, which made landfall on 24 September. MODIS Aqua true color imagery revealed high turbidity levels in shelf waters immediately following the storms indicative of intense resuspension. However, imagery following the landfall of Katrina showed relatively rapid return of shelf water mass properties to pre-storm conditions. Indeed, MODIS Aqua-derived estimates of diffuse attenuation at 490 nm (K_490) and chlorophyll (chlor_a) from mid-August prior to the landfall of Hurricane Katrina were comparable to those observed in mid-September following the storm. Regions of elevated K_490 and chlor_a were evident in offshore waters and appeared to be associated with cyclonic circulation (cold-core eddies) identified on the basis of sea surface height anomaly (SSHA). Imagery acquired shortly after Hurricane Rita made landfall showed increased water column turbidity extending over a large area of the shelf off Louisiana and Texas, consistent with intense resuspension and sediment disturbance. An interannual comparison of satellite-derived estimates of K_490 for late September and early October revealed relatively lower levels in 2005, compared to the mean for the prior three years, in the vicinity of the Mississippi River birdfoot delta. In contrast, levels above the previous three year mean were observed off Texas and Louisiana 7-10 d after the passage of Rita. The lower values of K_490 near the delta could be attributed to relatively low river discharge during the preceding months of the 2005 season. The elevated levels off Texas and

  13. Hurricanes Katrina and Rita: Temporary Emergency Impact Aid Provided Education Support for Displaced Students. Report to the Congressional Requesters. GAO-11-839

    ERIC Educational Resources Information Center

    Scott, George A.

    2011-01-01

    In August and September 2005, Hurricanes Katrina and Rita devastated large portions of the U.S. Gulf Coast, resulting in nearly 2,000 deaths and severe damage to 305,000 houses and apartments. Thousands of families relocated to communities throughout the United States and enrolled their children in local public or private schools. Some families…

  14. Soil temperature and moisture dynamics after experimental irrigation on two contrasting soils on the Santa Rita Experimental Range: Implications for mesquite establishment

    Treesearch

    Nathan B. English; David G. Williams; Jake F. Weltzin

    2003-01-01

    We established a large-scale manipulative experiment in a semidesert grassland on the Santa Rita Experimental Range to determine how the recruitment and physiology of woody plants (Prosopis velutina Woot.) are affected by invasive grasses, seasonal precipitation regimes, and underlying soil characteristics. We established 72 2.8-m2 plots beneath six large rainout...

  15. Nonlinear terms in storm surge predictions: Effect of tide and shelf geometry with case study from Hurricane Rita

    NASA Astrophysics Data System (ADS)

    Rego, JoãO. L.; Li, Chunyan

    2010-06-01

    This study applied the finite volume coastal ocean model (FVCOM) to the storm surge induced by Hurricane Rita along the Louisiana-Texas coast. The model was calibrated for tides and validated with observed water levels. Peak water levels were shown to be lower than expected for a landfall at high tide. For low- and high-tide landfalls, nonlinear effects due to tide-surge coupling were constructive and destructive to total storm tide, respectively, and their magnitude reached up to 70% of the tidal amplitude in the Rita application. Tide-surge interaction was further examined using a standard hurricane under idealized scenarios to evaluate the effects of various shelf geometries, tides, and landfall timings (relative to tide). Nonlinearity was important between landfall position and locations within 2.5 × radius of maximum winds. On an idealized wide continental shelf, nonlinear effects reached up to 80% of the tidal amplitude with an S2 tide and up to 47% with a K1 tide. Increasing average depths by 4 m reduced nonlinear effects to 41% of the tidal amplitude; increasing the slope by a factor of 3 produced nonlinearities of just 26% of tide (both with a K1 tide). The nonlinear effect was greatest for landfalls at low tide, followed by landfalls at high tide and then by landfalls at midebb or midflood.

  16. The Hurricane Rainband and Intensity Change Experiment (RAINEX): Observations and Modeling of Hurricanes Katrina, Ophelia, and Rita (2005)

    NASA Astrophysics Data System (ADS)

    Houze, R. A.

    2006-12-01

    The Hurricane Rainband and Intensity Change Experiment (RAINEX) used three P3 aircraft aided by high- resolution numerical modeling and satellite communications to investigate the 2005 Hurricanes Katrina, Ophelia, and Rita. The aim was to increase the understanding of tropical cyclone intensity change by interactions between a tropical cyclone's inner core and rainbands. All three aircraft had dual-Doppler radars, with the ELDORA radar on board the Naval Research Laboratory's P3 aircraft, providing particularly detailed Doppler radar data. Numerical model forecasts helped plan the aircraft missions, and innovative communications and data transfer in real time allowed the flights to be coordinated from a ground-based operations center. The P3 aircraft released approximately 600 dropsondes in locations targeted for optimal coordination with the Doppler radar data, as guided by the operations center. The storms were observed in all stages of development, from Tropical Depression to Category 5 hurricane. The data from RAINEX are readily available through an online Field Catalog and RAINEX Data Archive. The RAINEX dataset is illustrated by a preliminary analysis of Hurricane Rita, which was documented by multi-aircraft flights on five days: 1) while a tropical storm, 2) while rapidly intensifying to a Category 5 hurricane, 3) during an eyewall replacement, 4) when the hurricane became asymmetric upon encountering environmental shear, and 5) just prior to landfall.

  17. Drug resistance to inhibitors of the human double minute-2 E3 ligase is mediated by point mutations of p53, but can be overcome with the p53 targeting agent RITA.

    PubMed

    Jones, Richard J; Bjorklund, Chad C; Baladandayuthapani, Veerabhadran; Kuhn, Deborah J; Orlowski, Robert Z

    2012-10-01

    The human double minute (HDM)-2 E3 ubiquitin ligase plays a key role in p53 turnover and has been validated preclinically as a target in multiple myeloma (MM) and mantle cell lymphoma (MCL). HDM-2 inhibitors are entering clinical trials, and we therefore sought to understand potential mechanisms of resistance in lymphoid models. Wild-type p53 H929 MM and Granta-519 MCL cells resistant to MI-63 or Nutlin were generated by exposing them to increasing drug concentrations. MI-63-resistant H929 and Granta-519 cells were resistant to Nutlin, whereas Nutlin-resistant cells displayed cross-resistance to MI-63. These cells also showed cross-resistance to bortezomib, doxorubicin, cisplatin, and melphalan, but remained sensitive to the small molecule inhibitor RITA (reactivation of p53 and induction of tumor cell apoptosis). HDM-2 inhibitor-resistant cells harbored increased p53 levels, but neither genotoxic nor nongenotoxic approaches to activate p53 induced HDM-2 or p21. Resequencing revealed wild-type HDM-2, but mutations were found in the p53 DNA binding and dimerization domains. In resistant cells, RITA induced a G(2)-M arrest, upregulation of p53 targets HDM-2, PUMA, and NOXA, and PARP cleavage. Combination regimens with RITA and MI-63 resulted in enhanced cell death compared with RITA alone. These findings support the possibility that p53 mutation could be a primary mechanism of acquired resistance to HDM-2 inhibitors in MCL and MM. Furthermore, they suggest that simultaneous restoration of p53 function and HDM-2 inhibition is a rational strategy for clinical translation.

  18. The burden of rare cancers in Italy: the surveillance of rare cancers in Italy (RITA) project.

    PubMed

    Trama, Annalisa; Mallone, Sandra; Ferretti, Stefano; Meduri, Francesca; Capocaccia, Riccardo; Gatta, Gemma

    2012-01-01

    The project Surveillance of rare cancers in Italy (RITA) provides, for the first time, estimates of the burden of rare cancers in Italy based on the list of rare cancers proposed in collaboration with the European project Surveillance of Rare Cancers in Europe (RARECARE). RITA analyzed data from Italian population-based cancer registries (CR). The period of diagnosis was 1988 to 2002, and vital status information was available up to December 31, 2003. Incidence rates were estimated for the period 1995-2002, survival for the years 2000-2002 (with the period method of Brenner), and complete prevalence at January 1, 2003. Rare cancers are those with an incidence <6/100,000/year. In Italy, every year there are 60,000 new diagnoses of rare cancers corresponding to 15% of all new cancer diagnoses. Five-year relative survival was on the average worse for rare cancers (53%) than for common cancers (73%). A total of 770,000 patients were living in Italy in 2008 with a diagnosis of a rare cancer, 22% of the total cancer prevalence. Our estimates constitute a useful base for further research and support the idea that rare cancers are a public health problem that deserves attention. Centers of expertise for rare cancers that pool cases, expertise and resources could ensure an adequate clinical management for these diseases. Our data also showed that cancer registries are suitable sources of data to estimate incidence, prevalence and survival for rare cancers and should continue to monitoring rare cancers in Italy.

  19. Homage to Rita Levi-Montalcini, the queen of modern neuroscience.

    PubMed

    Aloe, Luigi; Chaldakov, George N

    2013-08-01

    The first cell growth factor, nerve growth factor (NGF), was discovered by Rita Levi-Montalcini (RLM) in the early 1950s. Originally identified as neurite outgrowth-stimulating factor, later studies revealed that non-neuronal cells, including immune cells, endothelial cells, cardiomyocytes, pancreatic beta cells, prostate epithelial and adipose tissue cells, were also targets for and/or sources of NGF. Nerve growth factor is well recognised as mediating multiple biological phenomena, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other members of the neurotrophin family are implicated in the pathogenesis of a large spectrum of neuronal and non-neuronal diseases, ranging from Alzheimer's and other neurodegenerative diseases to atherosclerosis and cardiometabolic disorders. Recent studies have demonstrated the therapeutic potentials of NGF in these conditions, including ocular and cutaneous diseases. NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma and urinary bladder syndromes. Here, we briefly describe the 'unpredictable' ideogenesis of the discovery of NGF, a eureka in the neuroscience. © 2013 International Federation for Cell Biology.

  20. Airborne mapping of chemical plumes in the aftermath of Hurricanes Katrina and Rita

    NASA Astrophysics Data System (ADS)

    Lewis, Paul E.; Thomas, Mark J.; Kroutil, Robert T.; Combs, Roger; Cummings, Alan S.; Miller, Dave; Curry, Tim; Shen, Sylvia S.

    2006-05-01

    Infrared airborne spectral measurements were collected over the Gulf Coast area during the aftermath of Hurricanes Katrina and Rita. These measurements allowed surveillance for potentially hazardous chemical vapor releases from industrial facilities caused by storm damage. Data was collected with a mid-longwave infrared multispectral imager and a hyperspectral Fourier transform infrared spectrometer operating in a low altitude aircraft. Signal processing allowed detection and identification of targeted spectral signatures in the presence of interferents, atmospheric contributions, and thermal clutter. Results confirmed the presence of a number of chemical vapors. All detection results were immediately passed along to emergency first responders on the ground. The chemical identification, location, and vapor species concentration information were used by the emergency response ground teams for identification of critical plume releases and subsequent mitigation.

  1. Effects of Stress After Hurricanes Katrina and Rita on Pubertal Disorders in Children

    PubMed Central

    Ponnapakkam, Adharsh; Gensure, Robert

    2008-01-01

    Hurricanes Katrina and Rita caused widespread damage that resulted in increased stress levels for families living in the New Orleans area. This study examined the relationship between this stress and the onset of puberty in children by conducting a retrospective chart review of patients referred before and after the storm to a pediatric endocrine practice in New Orleans. The total number of new patients referred and the incidence of diagnoses that are unlikely to be affected by stress (ie, thyroid disease and premature adrenarche) were essentially unchanged. On the other hand, the incidence of central precocious puberty decreased by 52% after the storm, while the incidence of pubertal delay increased by 9% in the post storm period. This study thus provides evidence that stress delays the onset of puberty in children. PMID:21603464

  2. Soviet Perceptions of War and Peace,

    DTIC Science & Technology

    1981-01-01

    Scott and Harriet Fast Scott Publications for a Purpose ...................................... 98 Continuity and Change in Soviet Perceptions...and Harriet Scott examine Soviet military strategies and forces; I address and provide a historical overview of the concept of peaceful coexistence...15. Marshal V.D. Sokolovskiy, ed., Soviet Military Strategy, 3d ed. edited by Harriet F. Scott (New York: Crane, Russak and Co., 1975), pp. 334-361

  3. Satellite Assessment of Bio-Optical Properties of Northern Gulf of Mexico Coastal Waters Following Hurricanes Katrina and Rita

    PubMed Central

    Lohrenz, Steven E.; Cai, Wei-Jun; Chen, Xiaogang; Tuel, Merritt

    2008-01-01

    The impacts of major tropical storms events on coastal waters include sediment resuspension, intense water column mixing, and increased delivery of terrestrial materials into coastal waters. We examined satellite imagery acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS) ocean color sensor aboard the Aqua spacecraft following two major hurricane events: Hurricane Katrina, which made landfall on 29 August 2005, and Hurricane Rita, which made landfall on 24 September. MODIS Aqua true color imagery revealed high turbidity levels in shelf waters immediately following the storms indicative of intense resuspension. However, imagery following the landfall of Katrina showed relatively rapid return of shelf water mass properties to pre-storm conditions. Indeed, MODIS Aqua-derived estimates of diffuse attenuation at 490 nm (K_490) and chlorophyll (chlor_a) from mid-August prior to the landfall of Hurricane Katrina were comparable to those observed in mid-September following the storm. Regions of elevated K_490 and chlor_a were evident in offshore waters and appeared to be associated with cyclonic circulation (cold-core eddies) identified on the basis of sea surface height anomaly (SSHA). Imagery acquired shortly after Hurricane Rita made landfall showed increased water column turbidity extending over a large area of the shelf off Louisiana and Texas, consistent with intense resuspension and sediment disturbance. An interannual comparison of satellite-derived estimates of K_490 for late September and early October revealed relatively lower levels in 2005, compared to the mean for the prior three years, in the vicinity of the Mississippi River birdfoot delta. In contrast, levels above the previous three year mean were observed off Texas and Louisiana 7-10 d after the passage of Rita. The lower values of K_490 near the delta could be attributed to relatively low river discharge during the preceding months of the 2005 season. The elevated levels off Texas and

  4. Land area change and fractional water maps in the Chenier Plain, Louisiana, following hurricane Rita

    NASA Astrophysics Data System (ADS)

    Palaseanu-Lovejoy, M.; Kranenburg, C.; Brock, J. C.

    2009-12-01

    The objective of this study is to develop a fractional water map at 30-m resolution scale using QuickBird and/or IKONOS high-resolution imagery as dependent variable to investigate the impact of hurricane Rita in the Chenier Plain, Louisiana. Eleven different indices were tested to obtain a high-resolution land / water classification on QuickBird (acquired on 05/23/2003) and IKONOS (acquired on 03/25/2006) images. The percent area covered by water in the high resolution images varied from 22 to 26% depending on the index used , with the simple ratio index (red band / NIR band) accounting for the lowest percent and the blue ratio index (blue band / sum(all bands)) for the highest percent. Using the ERDAS NLCD (National Land Cover Data) Mapping tool module, 100, 000 stratified random sample points with minimum 1000 points per stratum were selected from the high resolution dependent variable as training information for the independent variable layers. The rules for the regression tree were created using the data mining software Rulequest Cubist v. 2.05. This information was used to generate a fractional water map for the entire Landsat scene. The increase in water areas of about 10 - 15% between 2003 to 2006, as well as temporary changes in the water - land configurations are attributed to remnant flooding and removal of aquatic vegetation caused by hurricane Rita, and water level variations caused by tidal and / or meteorological variations between the acquisition dates of the satellite images. This analysis can assist in monitoring post-hurricane wetland recovery and assess trends in land loss due to extreme storm events, although estimation of permanent land loss cannot be made until wetland areas have the opportunity to recover from hurricane impacts.

  5. Rita Roars Through a Warm Gulf September 22, 2005

    NASA Image and Video Library

    2005-09-22

    This sea surface height map of the Gulf of Mexico, with the Florida peninsula on the right and the Texas-Mexico Gulf Coast on the left, is based on altimeter data from four satellites including NASA’s Topex/Poseidon and Jason. Red indicates a strong circulation of much warmer waters, which can feed energy to a hurricane. This area stands 35 to 60 centimeters (about 13 to 23 inches) higher than the surrounding waters of the Gulf. The actual track of a hurricane is primarily dependent upon steering winds, which are forecasted through the use of atmospheric models. However, the interaction of the hurricane with the upper ocean is the primary source of energy for the storm. Hurricane intensity is therefore greatly affected by the upper ocean temperature structure and can exhibit explosive growth over warm ocean currents and eddies. Eddies are currents of water that run contrary to the direction of the main current. According to the forecasted track through the Gulf of Mexico, Hurricane Rita will continue crossing the warm waters of a Gulf of Mexico circulation feature called the Loop Current and then pass near a warm-water eddy called the Eddy Vortex, located in the north central Gulf, south of Louisiana. http://photojournal.jpl.nasa.gov/catalog/PIA06427

  6. Potential consequences of saltwater intrusion associated with Hurricanes Katrina and Rita: Chapter 6C in Science and the storms-the USGS response to the hurricanes of 2005

    USGS Publications Warehouse

    Steyer, Gregory D.; Perez, Brian C.; Piazza, Sarai C.; Suir, Glenn

    2007-01-01

    Hurricanes Katrina and Rita pushed salt water from the Gulf of Mexico well inland into freshwater marsh communities in coastal Louisiana. This paper describes the spatial extent of saltwater intrusion and provides an initial assessment of impacts (salt stress) to coastal marsh vegetation communities.

  7. Lead distributions and risks in New Orleans following Hurricanes Katrina and Rita.

    PubMed

    Abel, Michael T; Cobb, George P; Presley, Steven M; Ray, Gary L; Rainwater, Thomas R; Austin, Galen P; Cox, Stephen B; Anderson, Todd A; Leftwich, Blair D; Kendall, Ronald J; Suedel, Burton C

    2010-07-01

    During the last four years, significant effort has been devoted to understanding the effects that Hurricanes Katrina and Rita had on contaminant distribution and redistribution in New Orleans, Louisiana, USA, and the surrounding Gulf Coast area. Elevated concentrations were found for inorganic contaminants (including As, Fe, Pb, and V), several organic pollutants (polycyclic aromatic hydrocarbons, pesticides, and volatiles) and high concentration of bioaerosols, particularly Aeromonas and Vibrio. Data from different research groups confirm that some contaminant concentrations are elevated, that existing concentrations are similar to historical data, and that contaminants such as Pb and As may pose human health risks. Two data sets have been compiled in this article to serve as the foundation for preliminary risk assessments within greater New Orleans. Research from the present study suggests that children in highly contaminated areas of New Orleans may experience Pb exposure from soil ranging from 1.37 microg/d to 102 microg/d. These data are critical in the evaluation of children's health. Copyright (c) 2010 SETAC.

  8. Gravity and Magnetic Surveys Over the Santa Rita Fault System, Southeastern Arizona

    USGS Publications Warehouse

    Hegmann, Mary

    2001-01-01

    Gravity and magnetic surveys were performed in the northeast portion of the Santa Rita Experimental Range, in southeastern Arizona, to identify faults and gain a better understanding of the subsurface geology. A total of 234 gravity stations were established, and numerous magnetic data were collected with portable and truck-mounted proton precession magnetometers. In addition, one line of very low frequency electromagnetic data was collected together with magnetic data. Gravity anomalies are used to identify two normal faults that project northward toward a previously identified fault. The gravity data also confirm the location of a second previously interpreted normal fault. Interpretation of magnetic anomaly data indicates the presence of a higher-susceptibility sedimentary unit located beneath lowersusceptibility surficial sediments. Magnetic anomaly data identify a 1-km-wide negative anomaly east of these faults caused by an unknown source and reveal the high variability of susceptibility in the Tertiary intrusive rocks in the area.

  9. Recent infection testing algorithm (RITA) applied to new HIV diagnoses in England, Wales and Northern Ireland, 2009 to 2011.

    PubMed

    Aghaizu, A; Murphy, G; Tosswill, J; DeAngelis, D; Charlett, A; Gill, O N; Ward, H; Lattimore, S; Simmons, Rd; Delpech, V

    2014-01-16

    In 2009, Public Health England (PHE) introduced the routine application of a recent infection testing algorithm (RITA) to new HIV diagnoses, where a positive RITA result indicates likely acquisition of infection in the previous six months. Laboratories submit serum specimens to PHE for testing using the HIV 1/2gO AxSYM assay modified for the determination of HIV antibody avidity. Results are classified according to avidity index and data on CD₄ count, antiretroviral treatment and the presence of an AIDS-defining illness. Between 2009 and 2011, 38.4% (6,966/18,134) of new HIV diagnoses in England, Wales and Northern Ireland were tested. Demographic characteristics of those tested were similar to all persons with diagnosed HIV. Overall, recent infection was 14.7% (1,022/6,966) and higher among men who have sex with men (MSM) (22.3%, 720/3,223) compared with heterosexual men and women (7.8%, 247/3,164). Higher proportions were among persons aged 15-24 years compared with those ≥50 years (MSM 31.2% (139/445) vs 13.6% (42/308); heterosexual men and women 17.3% (43/249) vs 6.2% (31/501)). Among heterosexual men and women, black Africans were least likely to have recent infection compared with whites (4.8%, 90/1,892 vs 13.3%, 97/728; adjusted odds ratio: 0.6; 95% CI: 0.4-0.9). Our results indicate evidence of ongoing HIV transmission during the study period, particularly among MSM.

  10. Characterization of airborne molds, endotoxins, and glucans in homes in New Orleans after Hurricanes Katrina and Rita.

    PubMed

    Rao, Carol Y; Riggs, Margaret A; Chew, Ginger L; Muilenberg, Michael L; Thorne, Peter S; Van Sickle, David; Dunn, Kevin H; Brown, Clive

    2007-03-01

    In August and September 2005, Hurricanes Katrina and Rita caused breeches in the New Orleans, LA, levee system, resulting in catastrophic flooding. The city remained flooded for several weeks, leading to extraordinary mold growth in homes. To characterize the potential risks of mold exposures, we measured airborne molds and markers of molds and bacteria in New Orleans area homes. In October 2005, we collected air samples from 5 mildly water-damaged houses, 15 moderately to heavily water-damaged houses, and 11 outdoor locations. The air filters were analyzed for culturable fungi, spores, (1-->3,1-->6)-beta-D-glucans, and endotoxins. Culturable fungi were significantly higher in the moderately/heavily water-damaged houses (geometric mean=67,000 CFU/m3) than in the mildly water-damaged houses (geometric mean=3,700 CFU/m3) (P=0.02). The predominant molds found were Aspergillus niger, Penicillium spp., Trichoderma, and Paecilomyces. The indoor and outdoor geometric means for endotoxins were 22.3 endotoxin units (EU)/m3 and 10.5 EU/m3, respectively, and for (1-->3,1-->6)-beta-D-glucans were 1.7 microg/m3 and 0.9 microg/m3, respectively. In the moderately/heavily water-damaged houses, the geometric means were 31.3 EU/m3 for endotoxins and 1.8 microg/m3 for (1-->3,1-->6)-beta-D-glucans. Molds, endotoxins, and fungal glucans were detected in the environment after Hurricanes Katrina and Rita in New Orleans at concentrations that have been associated with health effects. The species and concentrations were different from those previously reported for non-water-damaged buildings in the southeastern United States.

  11. Impacts of Hurricane Rita on the beaches of western Louisiana: Chapter 5D in Science and the storms-the USGS response to the hurricanes of 2005

    USGS Publications Warehouse

    Stockdon, Hilary F.; Fauver, Laura A.; Sallenger,, Asbury H.; Wright, C. Wayne

    2007-01-01

    Hurricane Rita made landfall as a category 3 storm in western Louisiana in late September 2005, 1 month following Hurricane Katrina's devastating landfall in the eastern part of the State. Large waves and storm surge inundated the lowelevation coastline, destroying many communities and causing extensive coastal change including beach, dune, and marsh erosion.

  12. The Law and Emergencies: Surveillance for Public Health–Related Legal Issues During Hurricanes Katrina and Rita

    PubMed Central

    Weiss, Rachel I.; McKie, Karen L.; Goodman, Richard A.

    2007-01-01

    Law influenced every aspect of the public health response to Hurricanes Katrina and Rita, from evacuation orders, to waivers of medical licensing requirements, to the clean-up of public health threats on private property. We used public health surveillance of news reports to identify and characterize legal issues arising during the disaster response in 5 Gulf Coast states. Data collected from news reports of the events in real time were followed-up by interviews with selected state legal and emergency management officials. Our analysis indicates the value of surveillance during and after emergency responses in identifying public health–related legal issues and helps to inform the strengthening of legal preparedness frameworks for future disasters. PMID:17413083

  13. After Hurricanes Katrina and Rita: Gender Differences in Health and Religiosity in Middle-Aged and Older Adults

    PubMed Central

    Brown, Jennifer Silva; Cherry, Katie E.; Marks, Loren D.; Jackson, Erin M.; Volaufova, Julia; Lefante, Christina; Jazwinski, S. Michal

    2011-01-01

    We examined health-related quality of life in adults in the Louisiana Healthy Aging Study (LHAS) after Hurricanes Katrina and Rita that made landfall on the United States Gulf Coast region in 2005. Analyses of pre- and post-disaster SF-36 scores yielded declines in physical function and bodily pain. Mental health scores were lower for women than men. Gender differences were observed in religious beliefs and religious coping, favoring women. Religious beliefs and religious coping were negatively correlated with physical function, implying that stronger reliance on religiosity as a coping mechanism may be more likely among those who are less physically capable. PMID:20924874

  14. After Hurricanes Katrina and Rita: gender differences in health and religiosity in middle-aged and older adults.

    PubMed

    Brown, Jennifer Silva; Cherry, Katie E; Marks, Loren D; Jackson, Erin M; Volaufova, Julia; Lefante, Christina; Jazwinski, S Michal

    2010-11-01

    We examined health-related quality of life in adults in the Louisiana Health Aging Study (LHAS) after Hurricanes Katrina and Rita (HK/R) that made landfall on the U.S. Gulf Coast region in 2005. Analyses of pre- and post-disaster SF-36 scores yielded changes in physical function and bodily pain. Mental health scores were lower for women than men. Gender differences were observed in religious beliefs and religious coping, favoring women. Religious beliefs and religious coping were negatively correlated with physical function, implying that stronger reliance on religiosity as a coping mechanism may be more likely among those who are less physically capable.

  15. Somatic experiencing treatment with social service workers following Hurricanes Katrina and Rita.

    PubMed

    Leitch, M Laurie; Vanslyke, Jan; Allen, Marisa

    2009-01-01

    In a disaster, social service workers are often survivors themselves.This study examines whether somatic intervention using a brief (one to two session) stabilization model now called the Trauma Resiliency Model (TRM), which uses the skills of Somatic Experiencing (SE), can reduce the postdisaster symptoms of social service workers involved in postdisaster service delivery.The study was implemented with a nonrandom sample of 142 social service workers who were survivors of Hurricanes Katrina and Rita in New Orleans and Baton Rouge, Louisiana, two to three months after the disasters. Ninety-one participants received SE/TRM and were compared with a matched comparison group of 51 participants through the use of propensity score matching. All participants first received group psychoeducation. Results support the benefits of the brief intervention inspired by SE. The treatment group showed statistically significant gains in resiliency indicators and decreases in posttraumatic stress disorder symptoms. Although psychological symptoms increased in both groups at the three to four month follow-up, the treatment group's psychological symptoms were statistically lower than those of the comparison group.

  16. The multiple life of nerve growth factor: tribute to rita levi-montalcini (1909-2012).

    PubMed

    Aloe, Luigi; Chaldakov, George N

    2013-03-01

    At the end of the 19(th) century, it was envisaged by Santiago Ramon y Cajal, but not, proven, that life at the neuronal level requires trophic support. The proof was obtained in the early 1950's by work initiated by Rita Levi-Montalcini (RLM) discovering the nerve growth factor (NGF). Today, NGF and its relatives, collectively designated neurotrophins, are well recognized as mediators of multiple biological phenomena in health and disease, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other neurotrophins are implicated in the pathogenesis of a large spectrum of neuronal and non-neuronal diseases, from Alzheimer's and other neurodegenerative diseases to atherosclerosis and other cardiometabolic diseases. Recent studies demonstrated the therapeutic potentials of NGF in these diseases, including ocular and cutaneous diseases. Furthermore, NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma, and urinary bladder syndromes. Altogether, NGF's multiple potential in health and disease is briefly described here.

  17. Schools' mental health responses after Hurricanes Katrina and Rita.

    PubMed

    Jaycox, Lisa H; Tanielian, Terri L; Sharma, Priya; Morse, Lindsey; Clum, Gretchen; Stein, Bradley D

    2007-10-01

    After the displacement of students following Hurricanes Katrina and Rita, schools in several states enrolled many students with potential mental health needs. This study sought to understand how schools perceived the mental health needs of these students and what mental health programs they implemented. Mental health personnel at 19 public schools or school systems and 11 private or parochial schools in Louisiana, Alabama, Texas, and Mississippi were interviewed at two time points (spring and fall-winter of 2006). Schools undertook diverse approaches to interventions, depending on the preexisting mental health infrastructure and personnel, the perceived needs of students, and the barriers or facilitators in each system. Interviewees described a rapid and comprehensive approach to the crisis in the immediate aftermath. Shortly afterward, some schools perceived little need for mental health services and refocused on their academic missions. Other school systems perceived student need but were unable to implement trauma-focused programs because staff were not prepared to deliver such services and funding was lacking. However, some systems and schools were able to implement new programs or extend programs to displaced students. Implementation challenges included difficulty communicating with parents, burnout among staff and program implementers, and efforts to balance the needs of the displaced students with those of the preexisting student population. Despite significant efforts to support students affected by the hurricanes, schools were limited in their ability to implement disaster-focused programs. Extension of crisis plans to include precrisis training in mental health programming for students and staff who have ongoing difficulties after a disaster or crisis may be beneficial.

  18. A prospective study of religiousness and psychological distress among female survivors of Hurricanes Katrina and Rita.

    PubMed

    Chan, Christian S; Rhodes, Jean E; Pérez, John E

    2012-03-01

    This prospective study examined the pathways by which religious involvement affected the post-disaster psychological functioning of women who survived Hurricanes Katrina and Rita. The participants were 386 low-income, predominantly Black, single mothers. The women were enrolled in the study before the hurricane, providing a rare opportunity to document changes in mental health from before to after the storm, and to assess the protective role of religious involvement over time. Results of structural equation modeling indicated that, controlling for level of exposure to the hurricanes, pre-disaster physical health, age, and number of children, pre-disaster religiousness predicted higher levels of post-disaster (1) social resources and (2) optimism and sense of purpose. The latter, but not the former, was associated with better post-disaster psychological outcome. Mediation analysis confirmed the mediating role of optimism and sense of purpose.

  19. Bacteriological water quality in the Lake Pontchartrain basin Louisiana following Hurricanes Katrina and Rita, September 2005

    USGS Publications Warehouse

    Stoeckel, Donald M.; Bushon, Rebecca N.; Demcheck, Dennis K.; Skrobialowski, Stanley C.; Kephart, Christopher M.; Bertke, Erin E.; Mailot, Brian E.; Mize, Scott V.; Fendick, Robert B.

    2005-01-01

    The U.S. Geological Survey (USGS), in collaboration with the Louisiana Department of Environmental Quality, monitored bacteriological quality of water at 22 sites in and around Lake Pontchartrain, La., for three consecutive weeks beginning September 13, 2005, following hurricanes Katrina and Rita and the associated flooding. Samples were collected and analyzed by USGS personnel from the USGS Louisiana Water Science Center and the USGS Ohio Water Microbiology Laboratory. Fecal-indicator bacteria (Escherichia coli, enterococci, and fecal coliform) concentrations ranged from the detection limit to 36,000 colony-forming units per 100 milliliters. Data are presented in tabular form and as plots of data in the context of available historical data and water-quality standards and criteria for each site sampled. Quality-control data were reviewed to ensure that methods performed as expected in a mobile laboratory setting.

  20. A Prospective Study of Religiousness and Psychological Distress Among Female Survivors of Hurricanes Katrina and Rita

    PubMed Central

    Rhodes, Jean E.; Pérez, John E.

    2013-01-01

    This prospective study examined the pathways by which religious involvement affected the post-disaster psychological functioning of women who survived Hurricanes Katrina and Rita. The participants were 386 low-income, predominantly Black, single mothers. The women were enrolled in the study before the hurricane, providing a rare opportunity to document changes in mental health from before to after the storm, and to assess the protective role of religious involvement over time. Results of structural equation modeling indicated that, controlling for level of exposure to the hurricanes, pre-disaster physical health, age, and number of children, pre-disaster religiousness predicted higher levels of post-disaster (1) social resources and (2) optimism and sense of purpose. The latter, but not the former, was associated with better post-disaster psychological outcome. Mediation analysis confirmed the mediating role of optimism and sense of purpose. PMID:21626083

  1. Eye of the storm: analysis of shelter treatment records of evacuees to Acadiana from Hurricanes Katrina and Rita.

    PubMed

    Caillouet, L Philip; Paul, P Joseph; Sabatier, Steven M; Caillouet, Kevin A

    2012-01-01

    The objective of this study is to gain insight into the medical needs of disaster evacuees, through a review of experiential data collected in evacuation shelters in the days and weeks following Hurricanes Katrina and Rita in 2005, to better prepare for similar events in the future. Armed with the information and insights provided herein, it is hoped that meaningful precautions and decisive actions can be taken by individuals, families, institutions, communities, and officials should the Louisiana Gulf Coast-or any other area with well-known vulnerabilities-be faced with a future emergency. Demographic and clinical data that were recorded on paper documents during triage and treatment in evacuation shelters were later transcribed into a computerized database management system, with cooperation of the Department of Health Information Management at The University of Louisiana at Lafayette. Analysis of those contemporaneously collected data was undertaken later by the Louisiana Center for Health Informatics. Evacuation shelters, Parish Health Units, and other locations including churches and community centers were the venue for ad hoc clinics in the Acadiana region of Louisiana. The evacuee-patients-3,329 of them-whose information is reflected in the subject dataset were among two geographically distinct but similarly distressed groups: 1) evacuees from Hurricane Katrina that devastated New Orleans and other locales near Louisiana and neighboring states in late August 2005 and 2) evacuees from Hurricane Rita that devastated Southwest Louisiana and neighboring areas of Texas in September 2005. Patient data were collected by physicians, nurses, and other volunteers associated with the Operation Minnesota Lifeline (OML) deployment during the weeks following the events. Volunteer clinicians from OML provided triage and treatment services and documented those services as paper medical records. As the focus of the OML "mission of mercy" was entirely on direct individually

  2. Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX

    PubMed Central

    Spinnler, C; Hedström, E; Li, H; de Lange, J; Nikulenkov, F; Teunisse, A F A S; Verlaan-de Vries, M; Grinkevich, V; Jochemsen, A G; Selivanova, G

    2011-01-01

    Inactivation of the p53 tumour suppressor, either by mutation or by overexpression of its inhibitors Hdm2 and HdmX is the most frequent event in cancer. Reactivation of p53 by targeting Hdm2 and HdmX is therefore a promising strategy for therapy. However, Hdm2 inhibitors do not prevent inhibition of p53 by HdmX, which impedes p53-mediated apoptosis. Here, we show that p53 reactivation by the small molecule RITA leads to efficient HdmX degradation in tumour cell lines of different origin and in xenograft tumours in vivo. Notably, HdmX degradation occurs selectively in cancer cells, but not in non-transformed cells. We identified the inhibition of the wild-type p53-induced phosphatase 1 (Wip1) as the major mechanism important for full engagement of p53 activity accomplished by restoration of the ataxia telangiectasia mutated (ATM) kinase-signalling cascade, which leads to HdmX degradation. In contrast to previously reported transactivation of Wip1 by p53, we observed p53-dependent repression of Wip1 expression, which disrupts the negative feedback loop conferred by Wip1. Our study reveals that the depletion of both HdmX and Wip1 potentiates cell death due to sustained activation of p53. Thus, RITA is an example of a p53-reactivating drug that not only blocks Hdm2, but also inhibits two important negative regulators of p53 – HdmX and Wip1, leading to efficient elimination of tumour cells. PMID:21546907

  3. Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX.

    PubMed

    Spinnler, C; Hedström, E; Li, H; de Lange, J; Nikulenkov, F; Teunisse, A F A S; Verlaan-de Vries, M; Grinkevich, V; Jochemsen, A G; Selivanova, G

    2011-11-01

    Inactivation of the p53 tumour suppressor, either by mutation or by overexpression of its inhibitors Hdm2 and HdmX is the most frequent event in cancer. Reactivation of p53 by targeting Hdm2 and HdmX is therefore a promising strategy for therapy. However, Hdm2 inhibitors do not prevent inhibition of p53 by HdmX, which impedes p53-mediated apoptosis. Here, we show that p53 reactivation by the small molecule RITA leads to efficient HdmX degradation in tumour cell lines of different origin and in xenograft tumours in vivo. Notably, HdmX degradation occurs selectively in cancer cells, but not in non-transformed cells. We identified the inhibition of the wild-type p53-induced phosphatase 1 (Wip1) as the major mechanism important for full engagement of p53 activity accomplished by restoration of the ataxia telangiectasia mutated (ATM) kinase-signalling cascade, which leads to HdmX degradation. In contrast to previously reported transactivation of Wip1 by p53, we observed p53-dependent repression of Wip1 expression, which disrupts the negative feedback loop conferred by Wip1. Our study reveals that the depletion of both HdmX and Wip1 potentiates cell death due to sustained activation of p53. Thus, RITA is an example of a p53-reactivating drug that not only blocks Hdm2, but also inhibits two important negative regulators of p53 - HdmX and Wip1, leading to efficient elimination of tumour cells.

  4. Cosmetics or Radical Surgery? What’s Right For the Top Levels of the U.S Defense Establishment as it Downsizes?

    DTIC Science & Technology

    1993-04-15

    1992. Thompson, W. Scott, and Donaldson D. Frizzell, ed. The Lessons of Viet Nam . New York: Crane, Russak & Company, 1977. Thurman, General Maxwell R...Depuftt .f Deawss. w SOY Or qifMade Thk 4amest may wt be IS-ýi ft 1W 0Mp•"s u ftbwsbee.demadby lbs appespdAdks Of enls COSMETICS OR RADICAL SURGERY...Classification) Cosmetics or Radical Surgery? What’s Right for the Top Levels of the U.S. Defense Establishment as It Downsizes? 12. PERSONAL AUTHOR(S) LTC

  5. Distribution Patterns of Land Surface Water from Hurricanes Katrina and Rita

    NASA Image and Video Library

    2005-10-12

    The above images, derived from NASA QuikScat satellite data, show the extensive pattern of rain water deposited by Hurricanes Katrina and Rita on land surfaces over several states in the southern and eastern United States. These results demonstrate the capability of satellite scatterometers to monitor changes in surface water on land. The color scale depicts increases in radar backscatter (in decibels) between the current measurement and the mean of measurements obtained during the previous two weeks. The backscatter can be calibrated to measure increases in surface soil moisture resulting from rainfall. The yellow color corresponds to an increase of approximately 10 percent or more in surface soil moisture according to the calibration site of Lonoke, Ark. The two hurricanes deposited excessive rainfall over extensive regions of the Mississippi River basin. Basins the size of the Mississippi can take up to several weeks before such excess rainfall significantly increases the amount of river discharge in large rivers such as the Mississippi. With hurricane season not over until November 30, the potential exists for significant flooding, particularly if new rain water is deposited by new hurricanes when river discharge peaks up as a result of previous rainfalls. River discharge should be closely monitored to account for this factor in evaluating potential flood conditions in the event of further hurricanes. http://photojournal.jpl.nasa.gov/catalog/PIA03029

  6. Nephrologic Impact of Hurricanes Katrina and Rita in Areas Not Directly Affected.

    PubMed

    Dossabhoy, Neville R; Qadri, Mashood; Beal, Lauren M

    2015-01-01

    Hurricanes Katrina and Rita resulted in enormous loss of life and disrupted the delivery of health care in areas affected by them. In causing mass movements of patients, natural disasters can overwhelm the resources of nephrology communities in areas not suffering direct damage. The following largely personal account evaluates the impact these hurricanes had upon the nephrology community, patients and health care providers alike, in areas not directly affected by the storms. Mass evacuation of hundreds of dialysis patients to surrounding areas overwhelmed the capacity of local hemodialysis centers. Non-availability of medical records in patients arriving without a supply of their routine medications led to confusion and sub-optimal treatment of conditions such as hypertension and congestive heart failure. Availability of cadaveric organs for transplantation was reduced in the surrounding areas, as the usual lines of communication and transportation were severed for several weeks. All of these issues led to prolong waiting times for patients on the transplant list. The hurricanes severely disrupted usual supply lines of medications to hospitals; certain rare conditions may be seen in higher numbers as a result of the shortages induced. We present the interesting surge in cases of acute kidney injury secondary to use of intravenous immune globulin.

  7. Changes in microbial community structure in the wake of Hurricanes Katrina and Rita

    PubMed Central

    Amaral-Zettler, Linda A.; Rocca, Jennifer D.; LaMontagne, Michael G.; Dennett, Mark R.; Gast, Rebecca J.

    2009-01-01

    Hurricanes have the potential to alter the structures of coastal ecosystems and generate pathogen-laden floodwaters that threaten public health. To examine the impact of hurricanes on urban systems, we compared microbial community structures in samples collected after Hurricane Katrina and before and after Hurricane Rita. We extracted environmental DNA and sequenced small-subunit ribosomal RNA (SSU rRNA) gene clone libraries to survey microbial communities in floodwater, water and sediment samples collected from Lake Charles, Lake Pontchartrain, the 17th Street and Industrial Canals in New Orleans and raw sewage. Correspondence Analysis showed that microbial communities associated with sediments formed one cluster while communities associated with lake and Industrial Canal water formed a second. Communities associated with water from the 17th Street Canal and floodwaters collected in New Orleans showed similarity to communities in raw sewage and contained a number of sequences associated with possible pathogenic microbes. This suggests that a distinct microbial community developed in floodwaters following Hurricane Katrina and that microbial community structures as a whole might be sensitive indicators of ecosystem health and serve as “sentinels” of water quality in the environment. PMID:19174873

  8. Changes in microbial community structure in the wake of Hurricanes Katrina and Rita.

    PubMed

    Amaral-Zettler, Linda A; Rocca, Jennifer D; Lamontagne, Michael G; Dennett, Mark R; Gast, Rebecca J

    2008-12-15

    Hurricanes have the potential to alter the structures of coastal ecosystems and generate pathogen-laden floodwaters thatthreaten public health. To examine the impact of hurricanes on urban systems, we compared microbial community structures in samples collected after Hurricane Katrina and before and after Hurricane Rita. We extracted environmental DNA and sequenced small-subunit rRNA (SSU rRNA) gene clone libraries to survey microbial communities in floodwater, water, and sediment samples collected from Lake Charles, Lake Pontchartrain, the 17th Street and Industrial Canals in New Orleans, and raw sewage. Correspondence analysis showed that microbial communities associated with sediments formed one cluster while communities associated with lake and Industrial Canal water formed a second. Communities associated with water from the 17th Street Canal and floodwaters collected in New Orleans showed similarity to communities in raw sewage and contained a number of sequences associated with possible pathogenic microbes. This suggests that a distinct microbial community developed in floodwaters following Hurricane Katrina and that microbial community structures as a whole might be sensitive indicators of ecosystem health and serve as "sentinels" of water quality in the environment.

  9. Data access and dissemination for emergency response and long-term recovery efforts related to Hurricanes Katrina and Rita: Chapter 4B in Science and the storms-the USGS response to the hurricanes of 2005

    USGS Publications Warehouse

    Wilson, Scott; Cretini, Chris

    2007-01-01

    The U.S. Geological Survey's (USGS) National Wetlands Research Center (NWRC) responded to Hurricanes Katrina and Rita by providing geospatial support to Federal, State, and local partners. The NWRC used its data and information management systems to deliver aerial photography and maps to emergency responders in a time of critical need.

  10. Multicenter Phase II Study with Weekly Bendamustine and Paclitaxel as First- or Later-Line Therapy in Patients with Metastatic Breast Cancer: RiTa II Trial.

    PubMed

    Loibl, Sibylle; Doering, Gabriele; Müller, Lothar; Grote-Metke, Albert; Müller, Roberto; Tomé, Oliver; Wiest, Wolfgang; Maisch, Andrea; Nekljudova, Valentina; von Minckwitz, Gunter

    2011-12-01

    The combination of bendamustine (B) and paclitaxel (P) as anthracycline-free treatment option in patients with advanced breast cancer has been evaluated in the previous RiTa I trial. The regimen of weekly B 70 mg/m(2) and P 90 mg/m(2) with a pause every 4th week was established as an effective regimen with low toxicity. The aim of the present RiTa II study was to investigate the potential of BP as anthracycline-free combination therapy. The primary objective was to determine the progression-free survival (PFS); secondary endpoints were safety, tolerability, overall response rate (ORR) and overall survival (OS). 26 patients were available, 15 received BP as first-line, 11 as beyond first-line treatment. 27% patients had triple-negative breast cancer (TNBC). Median PFS and OS were 7.3 months (95% confidence interval (CI): 5.5-10.9) and 14.9 months (95% CI: 9.9-22.9), respectively. The 1-year PFS rate was 20.3% and the 1-year OS rate 71.2%. The ORR was 42.3%, including 4 complete and 7 partial remissions. TNBC patients reached an ORR of 71.4%. Anthracycline-pretreated patients showed an ORR of 43.8%, confirming bendamustine's lack of cross-resistance to anthracycline agents. BP represents a favorable option with moderate toxicity in pretreated metastatic breast cancer and offers a possibility for application in anthracycline-pretreated and TNBC patients.

  11. Post-hurricane Rita mosquito surveillance and the efficacy of Air Force aerial applications for mosquito control in east Texas.

    PubMed

    Breidenbaugh, Mark S; Haagsma, Karl A; Walker, Wes W; Sanders, David M

    2008-06-01

    Post-Hurricane Rita mosquito surveillance was carried out in 4 east Texas counties to determine mosquito abundance, species composition, and need for mosquito control. Subsequently, aerial applications of naled (Dibrom) for mosquito control were made by the Air Force Aerial Spray Flight, while continued surveillance documented the efficacy of the applications. Psorophora columbiae was the predominant species in landing counts. Twenty-two mosquito species were represented in light trap collections with Aedes atlanitcus/tormentor, Culex nigripalpus, Ae. vexans, and Ps. columbiae making up 91% of the total. A total of 102,001 ha (252,052 acres) were aerially treated based on high mosquito abundance, exposure of first responders and residents to nuisance biting, and local interruption of electric utilities. A significant 90% decline in mosquito abundance was observed posttreatment.

  12. Dissolved and Colloidal Trace Elements in the Mississippi River Delta Outflow after Hurricanes Katrina and Rita

    NASA Astrophysics Data System (ADS)

    Shim, M.; Swarzenski, P. W.; Shiller, A. M.

    2010-12-01

    The Mississippi River (MR) plays an important role as a major fluvial source of dissolved and particulate materials for the Gulf of Mexico (GOM). This region is periodically disturbed by tropical weather systems including major hurricanes. Such storms have the potential to stir up the normally stratified water column of the Louisiana Shelf and thus can serve as a mechanism for the abrupt termination of seasonal bottom water hypoxia. Additionally, strong tropical systems can cause the resuspension of shelf bottom sediments which could result in the injection of trace elements into the water column. In the summer of 2005, two major hurricanes, Katrina and Rita, passed over the Louisiana Shelf within a month of each other. Three weeks after Rita, we participated in a survey of the waters of the Mississippi River delta outflow, examining the distributions of trace elements (including Ba, Co, Cr, Cs, Cu, Fe, Mn, Ni, Re, U, V, and Zn) in a comparison with previous results in this area. We indeed observed that there was limited stratification on the shelf and that bottom waters were no longer hypoxic. This resulted, for instance, in bottom water dissolved Mn being lower than is typically observed during hypoxia, but with concentrations still compatible with Mn-O2 trends previously reported. Interestingly, for no element were we able to identify an obvious effect of sediment resuspension on its distribution. In general, elemental distributions were compatible with previous observations in the Mississippi outflow system. Co and Re, which have not been reported for this system previously, showed behavior consistent with other systems: input for Co likely from desorption and conservative mixing for Re. For Cs, an element for which there is little information regarding its estuarine behavior, conservative mixing was also observed. Our filtration method, which allowed us to distinguish the dissolved (<0.02 µm) from colloidal (0.02 - 0.45 µm) phase, revealed significant

  13. Emplacement of the Santa Rita Flat pluton as a pluton-scale saddle reef

    NASA Astrophysics Data System (ADS)

    Vines, John A.; Law, Richard D.

    2000-12-01

    Regional mapping indicates that the Middle Jurassic Santa Rita Flat pluton, exposed in the Inyo Range of eastern California, is situated within the core of a south-plunging synform defined by bedding in the surrounding metasedimentary wall rocks, which dip beneath the pluton. However, bedding in rocks preserved above the pluton defines a south-plunging antiform. Anisotropy of magnetic susceptibility analysis revealed that magnetic foliation within the pluton also defines a south-plunging antiform, and the accompanying magnetic lineation plunges subparallel to the axis of this antiform. Our data indicate that the pluton was initially intruded as a sill in the hinge zone of the enveloping synform. Subsequent vertical inflation of the sill resulted in upward doming of the overlying roof and formation of the antiform now observed at the current erosion level in the pluton and preserved roof rocks. Emplacement of the pluton at 164 ± 1.5 Ma (U-Pb zircon age) overlaps in time with regional thrust faulting and folding ca. 185 148 Ma recognized in the southern Inyo Range. We speculate that space for initial emplacement of the pluton was produced during folding by layer-parallel slip and hinge-zone dilation, producing a saddle reef-like structure.

  14. Effects of hurricanes Katrina and Rita on Louisiana black bear habitat

    USGS Publications Warehouse

    Clark, Joseph D.; Murrow, Jennifer L.

    2012-01-01

    The Louisiana black bear (Ursus americanus luteolus) is comprised of 3 subpopulations, each being small, geographically isolated, and vulnerable to extinction. Hurricanes Katrina and Rita struck the Louisiana and Mississippi coasts in 2005, potentially altering habitat occupied by this federally threatened subspecies. We used data collected on radio-telemetered bears from 1993 to 1995 and pre-hurricane landscape data to develop a habitat model based on the Mahalanobis distance (D2) statistic. We then applied that model to post-hurricane landscape data where the telemetry data were collected (i.e., occupied study area) and where bear range expansion might occur (i.e., unoccupied study area) to quantify habitat loss or gain. The D2 model indicated that quality bear habitat was associated with areas of high mast-producing forest density, low water body density, and moderate forest patchiness. Cross-validation and testing on an independent data set in central Louisiana indicated that prediction and transferability of the model were good. Suitable bear habitat decreased from 348 to 345 km2 (0.9%) within the occupied study area and decreased from 34,383 to 33,891 km2 (1.4%) in the unoccupied study area following the hurricanes. Our analysis indicated that bear habitat was not significantly degraded by the hurricanes, although changes that could have occurred on a microhabitat level would be more difficult to detect at the resolution we used. We suggest that managers continue to monitor the possible long-term effects of these hurricanes (e.g., vegetation changes from flooding, introduction of toxic chemicals, or water quality changes).

  15. A Green Prison: Santa Rita Jail Creeps Towards Zero Net Energy (ZNE)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marnay, Chris; DeForest, Nicholas; Stadler, Michael

    2011-03-18

    A large project is underway at Alameda County's twenty-year old 45 ha 4,000-inmate Santa Rita Jail, about 70 km east of San Francisco. Often described as a green prison, it has a considerable installed base of distributed energy resources including a seven-year old 1.2 MW PV array, a four-year old 1 MW fuel cell with heat recovery, and efficiency investments. A current US$14 M expansion will add approximately 2 MW of NaS batteries, and undetermined wind capacity and a concentrating solar thermal system. This ongoing effort by a progressive local government with considerable Federal and State support provides some excellentmore » lessons for the struggle to lower building carbon footprint. The Distributed Energy Resources Customer Adoption Model (DER-CAM) finds true optimal combinations of equipment and operating schedules for microgrids that minimize energy bills and/or carbon emissions without 2 of 12 significant searching or rules-of-thumb prioritization, such as"efficiency first then on-site generation." The results often recommend complex systems, and sensitivities show how policy changes will affect choices. This paper reports an analysis of the historic performance of the PV system and fuel cell, describes the complex optimization applied to the battery scheduling, and shows how results will affect the jail's operational costs, energy consumption, and carbon footprint. DER-CAM is used to assess the existing and proposed DER equipment in its ability to reduce tariff charges.« less

  16. Impacts of Hurricanes Katrina and Rita on the microbial landscape of the New Orleans area

    PubMed Central

    Sinigalliano, C. D.; Gidley, M. L.; Shibata, T.; Whitman, D.; Dixon, T. H.; Laws, E.; Hou, A.; Bachoon, D.; Brand, L.; Amaral-Zettler, L.; Gast, R. J.; Steward, G. F.; Nigro, O. D.; Fujioka, R.; Betancourt, W. Q.; Vithanage, G.; Mathews, J.; Fleming, L. E.; Solo-Gabriele, H. M.

    2007-01-01

    Floodwaters in New Orleans from Hurricanes Katrina and Rita were observed to contain high levels of fecal indicator bacteria and microbial pathogens, generating concern about long-term impacts of these floodwaters on the sediment and water quality of the New Orleans area and Lake Pontchartrain. We show here that fecal indicator microbe concentrations in offshore waters from Lake Pontchartrain returned to prehurricane concentrations within 2 months of the flooding induced by these hurricanes. Vibrio and Legionella species within the lake were more abundant in samples collected shortly after the floodwaters had receded compared with samples taken within the subsequent 3 months; no evidence of a long-term hurricane-induced algal bloom was observed. Giardia and Cryptosporidium were detected in canal waters. Elevated levels of fecal indicator bacteria observed in sediment could not be solely attributed to impacts from floodwaters, as both flooded and nonflooded areas exhibited elevated levels of fecal indicator bacteria. Evidence from measurements of Bifidobacterium and bacterial diversity analysis suggest that the fecal indicator bacteria observed in the sediment were from human fecal sources. Epidemiologic studies are highly recommended to evaluate the human health effects of the sediments deposited by the floodwaters. PMID:17488814

  17. The effects of hurricane Rita and subsequent drought on alligators in southwest Louisiana.

    PubMed

    Lance, Valentine A; Elsey, Ruth M; Butterstein, George; Trosclair, Phillip L; Merchant, Mark

    2010-02-01

    Hurricane Rita struck the coast of southwest Louisiana in September 2005. The storm generated an enormous tidal surge of approximately four meters in height that inundated many thousands of acres of the coastal marsh with full strength seawater. The initial surge resulted in the deaths of a number of alligators and severely stressed those who survived. In addition, a prolonged drought (the lowest rainfall in 111 years of recorded weather data) following the hurricane resulted in highly saline conditions that persisted in the marsh for several months. We had the opportunity to collect 11 blood samples from alligators located on Holly Beach less than a month after the hurricane, but were unable to collect samples from alligators on Rockefeller Wildlife Refuge until February 2006. Conditions at Rockefeller Refuge did not permit systematic sampling, but a total of 201 samples were collected on the refuge up through August 2006. The blood samples were analyzed for sodium, potassium, chloride, osmolality, and corticosterone. Blood samples from alligators sampled on Holly Beach in October 2005, showed a marked elevation in plasma osmolality, sodium, chloride, potassium, corticosterone, and an elevated heterophil/lymphocyte ratio. Blood samples from alligators on Rockefeller Refuge showed increasing levels of corticosterone as the drought persisted and elevated osmolality and electrolytes. After substantial rainfall in July and August, these indices of osmotic stress returned to within normal limits. (c) 2009 Wiley-Liss, Inc.

  18. The effects of Hurricanes Katrina and Rita on seabed polycyclic aromatic hydrocarbon dynamics in the Gulf of Mexico.

    PubMed

    Mitra, Siddhartha; Lalicata, Joseph J; Allison, Mead A; Dellapenna, Timothy M

    2009-06-01

    To assess the extent to which Hurricanes Katrina and Rita affected polycyclic aromatic hydrocarbons (PAH) in the Gulf of Mexico (GOM), sediment cores were analyzed in late 2005 from: a shallow shelf, a deeper shelf, and a marsh station. Sediment geochronology, fabric, and geochemistry show that the 2005 storms deposited approximately 10cm of sediment to the surface of a core at 5-12A. Bulk carbon geochemistry and PAH isomers in this top layer suggest that the source of sediment to the top portion of core 5-12A was from a relatively more marine area. Particulate PAHs in the marsh core (04M) appeared unaffected by the storms while sediments in the core from Station 5-1B (deeper shelf) were affected minimally (some possible storm-derived deposition). Substantial amounts of PAH-laden particles may have been displaced from the seabed in shallow areas of the water column in the GOM by these 2005 storms.

  19. Galls and gall makers in plants from the Pé-de-Gigante Cerrado Reserve, Santa Rita do Passa Quatro, SP, Brazil.

    PubMed

    Urso-Guimarães, M V; Scareli-Santos, C

    2006-02-01

    Thirty-six morphologically different types of galls were obtained in leaves, leaflets, veins, petioles, stems, tendrils and flower buds from twenty-five species of plants in the Pé-de-Gigante Reserve, municipality of Santa Rita do Passa Quatro, state of São Paulo, Brazil. The host plant species belong to the closely related families Anacardiaceae, Annonaceae, Asteraceae, Bignoniaceae, Caryocaraceae, Erythroxylaceae, Fabaceae, Malpighiaceae, Melastomataceae, Myrtaceae, Ochnaceae, Polygalaceae, Sapindaceae, Sapotaceae, and Smilacaceae. The most common gall makers included Cecidomyiidae (Diptera), Pteromalidae (Hymenoptera) and Diaspididae (Sternorrhyncha-Hemiptera). This is the first report of galls found in the following plant genera: Gochnatia (Asteraceae), Distictela (Bignoniaceae), Banisteriopsis (Malpighiaceae), Ouratea (Ochnaceae), and Bredemeyera (Polygalaceae). The results of this work contribute to the body of knowledge about the relationship among host plants, gall makers, and the gall morphology of Pé-de-Gigante Cerrado Reserve.

  20. Chemical constituents in sediment in Lake Pontchartrain and in street mud and canal sediment in New Orleans, Louisiana, following Hurricanes Katrina and Rita, 2005

    USGS Publications Warehouse

    Van Metre, Peter C.; Wilson, Jennifer T.; Horowitz, Arthur J.; Skrobialowski, Stanley C.; Foreman, William T.; Fuller, Christopher C.; Burkhardt, Mark R.; Elrick, Kent A.; Mahler, Barbara J.; Smith, James J.; Zaugg, Steven D.

    2007-01-01

    Samples of street mud, suspended and bottom sediment in canals discharging to Lake Ponchartrain, and suspended and bottom sediment in the lake were collected and analyzed for chemical constituents to help evaluate the effects of Hurricanes Katrina and Rita and the subsequent unwatering of New Orleans, Louisiana. The approach used for sampling and analysis of chemical data for the study is presented herein. Radionuclides, major and trace elements, and numerous organic compounds in sediment were analyzed. The organic compounds include organochlorine pesticides, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, urban waste indicator compounds, and current-use pesticides. Methods for the analysis of urban waste indicator compounds and current-use pesticides in sediment were developed only recently.

  1. Hurricanes Katrina and Rita and the Department of Veterans Affairs: a conceptual model for understanding the evacuation of nursing homes.

    PubMed

    Dobalian, Aram; Claver, Maria; Fickel, Jacqueline J

    2010-01-01

    Hurricanes Katrina and Rita exposed significant flaws in US preparedness for catastrophic events and the nation's capacity to respond to them. These flaws were especially evident in the affected disaster areas' nursing homes, which house a particularly vulnerable population of frail older adults. Although evacuation of a healthcare facility is a key preparedness activity, there is limited research on factors that lead to effective evacuation. Our review of the literature on evacuation is focused on developing a conceptual framework to study future evacuations rather than as a comprehensive assessment of prior work. This paper summarizes what is known thus far about disaster response activities of nursing homes following natural and human-caused disasters, describes a conceptual model to guide future inquiry regarding this topic, and suggests future areas of research to further understand the decision-making process of nursing home facilitators regarding evacuating nursing home residents. To demonstrate the utility of the conceptual model and to provide guidance about effective practices and procedures, this paper focuses on the responses of Veterans Health Administration (VHA) nursing homes to the 2 hurricanes. Quarantelli's conceptual framework, as modified by Perry and Mushkatel, is useful in guiding the development of central hypotheses related to the decision-making that occurred in VA nursing homes and other healthcare facilities following Hurricanes Katrina and Rita. However, we define evacuation somewhat differently to account for the fact that evacuation may, in some instances, be permanent. Thus, we propose modifying this framework to improve its applicability beyond preventive evacuation. We need to better understand how disaster plans can be adapted to meet the needs of frail elders and other residents in nursing homes. Moreover, we must address identified gaps in the scientific literature with respect to health outcomes by tracking outcomes over time

  2. Hurricane Rita Track Radar Image with Topographic Overlay

    NASA Technical Reports Server (NTRS)

    2005-01-01

    [figure removed for brevity, see original site] Animation

    About the animation: This simulated view of the potential effects of storm surge flooding on Galveston and portions of south Houston was generated with data from the Shuttle Radar Topography Mission. Although it is protected by a 17-foot sea wall against storm surges, flooding due to storm surges caused by major hurricanes remains a concern. The animation shows regions that, if unprotected, would be inundated with water. The animation depicts flooding in one-meter increments.

    About the image: The Gulf Coast from the Mississippi Delta through the Texas coast is shown in this satellite image from NASA's Moderate Resolution Imaging Spectroradiometer (MODIS) overlain with data from the Shuttle Radar Topography Mission (SRTM), and the predicted storm track for Hurricane Rita. The prediction from the National Weather Service was published Sept. 22 at 4 p.m. Central Time, and shows the expected track center in black with the lighter shaded area indicating the range of potential tracks the storm could take.

    Low-lying terrain along the coast has been highlighted using the SRTM elevation data, with areas within 15 feet of sea level shown in red, and within 30 feet in yellow. These areas are more at risk for flooding and the destructive effects of storm surge and high waves.

    Data used in this image were acquired by the Shuttle Radar Topography Mission aboard the Space Shuttle Endeavour, launched on Feb. 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between

  3. Hazardous substances releases associated with Hurricanes Katrina and Rita in industrial settings, Louisiana and Texas.

    PubMed

    Ruckart, Perri Zeitz; Orr, Maureen F; Lanier, Kenneth; Koehler, Allison

    2008-11-15

    The scientific literature concerning the public health response to the unprecedented hurricanes striking the Gulf Coast in August and September 2005 has focused mainly on assessing health-related needs and surveillance of injuries, infectious diseases, and other illnesses. However, the hurricanes also resulted in unintended hazardous substances releases in the affected states. Data from two states (Louisiana and Texas) participating in the Hazardous Substances Emergency Events Surveillance (HSEES) system were analyzed to describe the characteristics of hazardous substances releases in industrial settings associated with Hurricanes Katrina and Rita. HSEES is an active multi-state Web-based surveillance system maintained by the Agency for Toxic Substances and Disease Registry (ATSDR). In 2005, 166 hurricane-related hazardous substances events in industrial settings in Louisiana and Texas were reported. Most (72.3%) releases were due to emergency shut downs in preparation for the hurricanes and start-ups after the hurricanes. Emphasis is given to the contributing causal factors, hazardous substances released, and event scenarios. Recommendations are made to prevent or minimize acute releases of hazardous substances during future hurricanes, including installing backup power generation, securing equipment and piping to withstand high winds, establishing procedures to shutdown process operations safely, following established and up-to-date start-up procedures and checklists, and carefully performing pre-start-up safety reviews.

  4. Recovery Migration After Hurricanes Katrina and Rita: Spatial Concentration and Intensification in the Migration System.

    PubMed

    Curtis, Katherine J; Fussell, Elizabeth; DeWaard, Jack

    2015-08-01

    Changes in the human migration systems of the Gulf of Mexico coastline counties affected by Hurricanes Katrina and Rita provide an example of how climate change may affect coastal populations. Crude climate change models predict a mass migration of "climate refugees," but an emerging literature on environmental migration suggests that most migration will be short-distance and short-duration within existing migration systems, with implications for the population recovery of disaster-stricken places. In this research, we derive a series of hypotheses on recovery migration predicting how the migration system of hurricane-affected coastline counties in the Gulf of Mexico was likely to have changed between the pre-disaster and the recovery periods. We test these hypotheses using data from the Internal Revenue Service on annual county-level migration flows, comparing the recovery period migration system (2007-2009) with the pre-disaster period (1999-2004). By observing county-to-county ties and flows, we find that recovery migration was strong: the migration system of the disaster-affected coastline counties became more spatially concentrated, while flows within it intensified and became more urbanized. Our analysis demonstrates how migration systems are likely to be affected by the more intense and frequent storms anticipated by climate change scenarios, with implications for the population recovery of disaster-affected places.

  5. Disaster-related exposures and health effects among US Coast Guard responders to Hurricanes Katrina and Rita: a cross-sectional study.

    PubMed

    Rusiecki, Jennifer A; Thomas, Dana L; Chen, Ligong; Funk, Renée; McKibben, Jodi; Dayton, Melburn R

    2014-08-01

    Disaster responders work among poorly characterized physical and psychological hazards with little understood regarding health consequences of their work. A survey administered to 2834 US Coast Guard responders to Hurricanes Katrina and Rita provided data on exposures and health effects. Prevalence odds ratios (PORs) evaluated associations between baseline characteristics, missions, exposures, and health effects. Most frequent exposures were animal/insect vector (n = 1309; 46%) and floodwater (n = 817; 29%). Most frequent health effects were sunburn (n = 1119; 39%) and heat stress (n = 810; 30%). Significant positive associations were for mold exposure and sinus infection (POR = 10.39); carbon monoxide and confusion (POR = 6.27); lack of sleep and slips, trips, falls (POR = 3.34) and depression (POR = 3.01); being a Gulf-state responder and depression (POR = 3.22). Increasing protection for disaster responders requires provisions for adequate sleep, personal protective equipment, and access to medical and psychological support.

  6. The Walnut Gulch - Santa Rita Wildland Watershed-Scale LTAR Sites

    NASA Astrophysics Data System (ADS)

    Goodrich, D. C.; Heilman, P.; Scott, R. L.; Nearing, M. A.; Moran, M. S.; Nichols, M.; Vivoni, E. R.; Archer, S. R.; Biederman, J.; Naito, A. T.

    2015-12-01

    The 150 km2 Walnut Gulch Experimental Watershed (WGEW), a Long-Term Agroecosystem Research (LTAR) site, near Tombstone, Arizona was established in 1953 by the USDA-ARS Southwest Watershed Research Center in Tucson. It is one of the most intensively instrumented semiarid experimental watersheds in the world with elevation ranging from 1220 to 1950 m with mean annual temperature and precipitation equal to 17.7°C and 312 mm. Desert shrubs dominate the lower two thirds of the watershed and grasses the upper third. Spatial variation in precipitation is measured with a network of 88 weighing-type recording rain gauges. Surface runoff is quantified over a range of scales (0.002 to 0.06 km2) to characterize interactions between rainfall intensity, soils and vegetation at nine sub-watersheds. Channel network processes and rainfall spatial variability are studied using 11 nested watersheds (2 to 150 km2). Sediment from the small sub-watersheds is sampled. Meteorological, soil moisture and temperature, and energy/water/CO2 flux measurements are made within two vegetation/soil complexes. Parallel investigations dating back to 1974 have also been conducted on eight small experimental watersheds at the Santa Rita Experimental Range (SRER) 80 km west of Walnut Gulch. In contrast to the creosote bush-grass WGEW, the mesquite-grass SRER is publicly owned, which ensures control and consistent reporting of management for research purposes. A key LTAR objective is to contrast a "business as usual" to an alternate management strategy presumed to have the potential of significantly improving forage and livestock production and diversification of ecosystem services. Consequently, a new ARS-U. of Arizona-Arizona State U. partnership will assess the watershed-scale impacts of brush management, a common land use practice typically applied in conjunction with livestock grazing, on a suite of ecosystem services at the SRER including provisioning (forage production, water yield), supporting

  7. Longitudinal Assessment of Cognitive and Psychosocial Functioning After Hurricanes Katrina and Rita: Exploring Disaster Impact on Middle-Aged, Older, and Oldest-Old Adults.

    PubMed

    Cherry, Katie E; Brown, Jennifer Silva; Marks, Loren D; Galea, Sandro; Volaufova, Julia; Lefante, Christina; Su, L Joseph; Welsh, David A; Jazwinski, S Michal

    2011-12-01

    The authors examined the effects of Hurricanes Katrina and Rita (HKR) on cognitive and psychosocial functioning in a lifespan sample of adults 6 to 14 months after the storms. Participants were recruited from the Louisiana Healthy Aging Study (LHAS). Most were assessed during the immediate impact period and retested for this study. Analyses of pre-and post-disaster cognitive data confirmed that storm-related decrements in working memory for middle-aged and older adults observed in the immediate impact period had returned to pre-hurricane levels in the post-disaster recovery period. Middle-aged adults reported more storm-related stressors and greater levels of stress than the two older groups at both waves of testing. These results are consistent with a burden perspective on post-disaster psychological reactions.

  8. Cheniere forest as stopover habitat for migrant landbirds: Immediate effects of Hurricane Rita: Chapter 6D in Science and the storms-the USGS response to the hurricanes of 2005

    USGS Publications Warehouse

    Barrow, Wylie; Chadwick, Paul; Couvillion, Brady R.; Doyle, Thomas; Faulkner, Stephen; Jeske, Clint; Michot, Tommy; Randall, Lori; Wells, Chris; Wilson, Scott

    2007-01-01

    It is not known whether en route fall migratory birds (August-October) are likely to suffer more from direct or secondary effects of hurricanes. On September 24, 2005, Hurricane Rita wreaked havoc on Louisiana's coast by toppling trees over vast areas and by stripping away microhabitats that harbor the invertebrates and produce the fruits upon which migrant landbirds depend (e.g., canopy foliage, vine tangles, epiphytes, leaf litter, and thickets of perennial plant species). Such transient effects of a hurricane on wildlife food resources are poorly understood, but these effects may have longterm consequences for some wildlife species.

  9. Recovery Migration after Hurricanes Katrina and Rita: Spatial Concentration and Intensification in the Migration System

    PubMed Central

    Fussell, Elizabeth; DeWaard, Jack

    2015-01-01

    Changes in the human migration systems of Hurricane Katrina- and Rita-affected Gulf of Mexico coastline counties provide an example of how climate change may affect coastal populations. Crude climate change models predict a mass migration of “climate refugees,” but an emerging literature on environmental migration suggests most migration will be short-distance and short-duration within existing migration systems, with implications for the population recovery of disaster-struck places. In this research, we derive a series of hypotheses on recovery migration predicting how the migration system of hurricane-affected coastline counties in the Gulf of Mexico was likely to have changed between the pre-disaster and the recovery periods. We test these hypotheses using data from the Internal Revenue Service on annual county-level migration flows, comparing the recovery period migration system (2007–2009) to the pre-disaster period (1999–2004). By observing county-to-county ties and flows we find that recovery migration was strong, as the migration system of the disaster-affected coastline counties became more spatially concentrated while flows within it intensified and became more urbanized. Our analysis demonstrates how migration systems are likely to be affected by the more intense and frequent storms anticipated by climate change scenarios with implications for the population recovery of disaster-affected places. PMID:26084982

  10. Land area changes in coastal Louisiana after Hurricanes Katrina and Rita: Chapter 5B in Science and the storms-the USGS response to the hurricanes of 2005

    USGS Publications Warehouse

    Barras, John A.

    2007-01-01

    Comparison of classified Landsat Thematic Mapper (TM) satellite imagery acquired before and after the landfalls of Hurricanes Katrina (August 29, 2005) and Rita (September 24, 2005) demonstrated that water area increased by 217 mi2 (562 km2) in coastal Louisiana. Approximately 82 mi2 (212 km2) of new water areas were in areas primarily impacted by Katrina (Mississippi River Delta basin, Breton Sound basin, Pontchartrain basin, Pearl River basin), whereas 117 mi2 (303 km2) were in areas primarily impacted by Rita (Calcasieu/ Sabine basin, Mermentau basin, Teche/Vermilion basin, Atchafalaya basin, Terrebonne basin). Barataria basin contained new water areas caused by both hurricanes, resulting in some 18 mi2 (46.6 km2) of new water areas. The fresh marsh and intermediate marsh communities' land areas decreased by 122 mi2 (316 km2) and 90 mi2 (233.1 km2), respectively. The brackish marsh and saline marsh communities' land areas decreased by 33 mi2 (85.5 km2) and 28 mi2 (72.5 km2), respectively. These new water areas identify permanent losses caused by direct removal of wetlands. They also indicate transitory water area changes caused by remnant flooding, removal of aquatic vegetation, scouring of marsh vegetation, and water-level variation attributed to normal tidal and meteorological variation between satellite images. Permanent losses cannot be estimated until several growing seasons have passed and the transitory impacts of the hurricanes are minimized. The purpose of this study was to provide preliminary information on water area changes in coastal Louisiana acquired shortly after both hurricanes' landfalls (detectable with Landsat TM imagery) and to serve as a regional baseline for monitoring posthurricane wetland recovery.

  11. Geomorphic and ecological effects of Hurricanes Katrina and Rita on coastal Louisiana marsh communities

    USGS Publications Warehouse

    Piazza, Sarai C.; Steyer, Gregory D.; Cretini, Kari F.; Sasser, Charles E.; Visser, Jenneke M.; Holm, Guerry O.; Sharp, Leigh A.; Evers, D. Elaine; Meriwether, John R.

    2011-01-01

    Hurricanes Katrina and Rita made landfall in 2005, subjecting the coastal marsh communities of Louisiana to various degrees of exposure. We collected data after the storms at 30 sites within fresh (12), brackish/intermediate (12), and saline (6) marshes to document the effects of saltwater storm surge and sedimentation on marsh community dynamics. The 30 sites were comprised of 15 pairs. Most pairs contained one site where data collection occurred historically (that is, prestorms) and one Coastwide Reference Monitoring System site. Data were collected from spring 2006 to fall 2007 on vegetative species composition, percentage of vegetation cover, aboveground and belowground biomass, and canopy reflectance, along with discrete porewater salinity, hourly surface-water salinity, and water level. Where available, historical data acquired before Hurricanes Katrina and Rita were used to compare conditions and changes in ecological trajectories before and after the hurricanes. Sites experiencing direct and indirect hurricane influences (referred to in this report as levels of influence) were also identified, and the effects of hurricane influence were tested on vegetation and porewater data. Within fresh marshes, porewater salinity was greater in directly impacted areas, and this heightened salinity was reflected in decreased aboveground and belowground biomass and increased cover of disturbance species in the directly impacted sites. At the brackish/intermediate marsh sites, vegetation variables and porewater salinity were similar in directly and indirectly impacted areas, but porewater salinity was higher than expected throughout the study. Interestingly, directly impacted saline marsh sites had lower porewater salinity than indirectly impacted sites, but aboveground biomass was greater at the directly impacted sites. Because of the variable and site-specific nature of hurricane influences, we present case studies to help define postdisturbance baseline conditions in

  12. Hurricane Rita surge data, southwestern Louisiana and southeastern Texas, September to November 2005

    USGS Publications Warehouse

    McGee, Benton D.; Goree, Burl B.; Tollett, Roland W.; Woodward, Brenda K.; Kress, Wade H.

    2006-01-01

    Pressure transducers and high-water marks were used to document the inland water levels related to storm surge generated by Hurricane Rita in southwestern Louisiana and southeastern Texas. On September 22-23, 2005, an experimental monitoring network consisting of 47 pressure transducers (sensors) was deployed at 33 sites over an area of about 4,000 square miles to record the timing, extent, and magnitude of inland hurricane storm surge and coastal flooding. Sensors were programmed to record date and time, temperature, and barometric or water pressure. Water pressure was corrected for changes in barometric pressure and salinity. Elevation surveys using global-positioning systems and differential levels were used to relate all storm-surge water-level data, reference marks, benchmarks, sensor measuring points, and high-water marks to the North American Vertical Datum of 1988 (NAVD 88). The resulting data indicated that storm-surge water levels over 14 feet above NAVD 88 occurred at three locations and rates of water-level rise greater than 5 feet per hour occurred at three locations near the Louisiana coast. Quality-assurance measures were used to assess the variability and accuracy of the water-level data recorded by the sensors. Water-level data from sensors were similar to data from co-located sensors, permanent U.S. Geological Survey streamgages, and water-surface elevations performed by field staff. Water-level data from sensors at selected locations were compared to corresponding high-water mark elevations. In general, the water-level data from sensors were similar to elevations of high quality high-water marks, while reporting consistently higher than elevations of lesser quality high-water marks.

  13. Observations of the structure and evolution of surface and flight-level wind asymmetries in Hurricane Rita (2005)

    NASA Astrophysics Data System (ADS)

    Rogers, Robert; Uhlhorn, Eric

    2008-11-01

    Knowledge of the magnitude and distribution of surface winds, including the structure of azimuthal asymmetries in the wind field, are important factors for tropical cyclone forecasting. With its ability to remotely measure surface wind speeds, the stepped frequency microwave radiometer (SFMR) has assumed a prominent role for the operational tropical cyclone forecasting community. An example of this instrument's utility is presented here, where concurrent measurements of aircraft flight-level and SFMR surface winds are used to document the wind field evolution over three days in Hurricane Rita (2005). The amplitude and azimuthal location (phase) of the wavenumber-1 asymmetry in the storm-relative winds varied at both levels over time. The peak was found to the right of storm track at both levels on the first day. By the third day, the peak in flight-level storm-relative winds remained to the right of storm track, but it shifted to left of storm track at the surface, resulting in a 60-degree shift between the surface and flight-level and azimuthal variations in the ratio of surface to flight-level winds. The asymmetric differences between the surface and flight-level maximum wind radii also varied, indicating a vortex whose tilt was increasing.

  14. Cognitive and Psychosocial Consequences of Hurricanes Katrina and Rita Among Middle-Aged, Older, and Oldest-Old Adults in the Louisiana Healthy Aging Study (LHAS)1

    PubMed Central

    Cherry, Katie E.; Su, L. Joseph; Welsh, David A.; Galea, Sandro; Jazwinski, S. Michal; Silva, Jennifer L.; Erwin, Marla J.

    2010-01-01

    This study examined the impact of Hurricanes Katrina and Rita on cognitive and psychosocial functioning among middle-aged (45–64 years), older (65–89 years) and oldest-old adults (90 years and over) in the Louisiana Healthy Aging Study (LHAS). Analyses of pre- and post-disaster cognitive data showed storm-related decrements in working memory for the middle-aged and older adults, but not for the oldest-old adults. Regression analyses confirmed that measures of social engagement and storm-related disruption significantly predicted pre- to post-disaster differences in short-term and working memory performance for the middle-aged and older adults only. These results are consistent with a burden perspective on post-disaster psychological reactions. Implications for current views of disaster reactions are discussed. PMID:21461124

  15. Mapping the spatial and temporal dynamics of the velvet mesquite with MODIS and AVIRIS: Case study at the Santa Rita Experimental Range

    NASA Astrophysics Data System (ADS)

    Kaurivi, Jorry Zebby Ujama

    The general objective of this research is to develop a methodology that will allow mapping and quantifying shrub encroachment with remote sensing. The multitemporal properties of the Moderate Resolution Imaging Spectroradiometer (MODIS) -250m, 16-day vegetation index products were combined with the hyperspectral and high spatial resolution (3.6m) computation of the Airborne Visible-Infrared Imaging Spectrometer (AVIRIS) to detect the dynamics of mesquite and grass/soil matrix at two sites of high (19.5%) and low (5.7%) mesquite cover in the Santa Rita Experimental Range (SRER). MODIS results showed separability between grassland and mesquite based on phenology. Mesquite landscapes had longer green peak starting in April through February, while the grassland only peaked during the monsoon season (July through October). AVIRIS revealed spectral separability, but high variation in the data implicated high heterogeneity in the landscape. Nonetheless, the methodology for larger data was developed in this study and combines ground, air and satellite data.

  16. The Muralla Pircada: an ancient Andean debris flow retention dam, Santa Rita B archaeological site, Chao Valley, Northern Peru

    USGS Publications Warehouse

    Brooks, William E.; Willett, Jason C.; Kent, Jonathan D.; Vasquez, Victor; Rosales, Teresa

    2005-01-01

    Debris flows caused by El Niño events, earthquakes, and glacial releases have affected northern Perú for centuries. The Muralla Pircada, a northeast-trending, 2.5 km long stone wall east of the Santa Rita B archaeological site (Moche-Chimú) in the Chao Valley, is field evidence that ancient Andeans recognized and, more importantly, attempted to mitigate the effects of debris flows. The Muralla is upstream from the site and is perpendicular to local drainages. It is 1–2 m high, up to 5 m wide, and is comprised of intentionally-placed, well-sorted, well-rounded, 20–30 cm cobbles and boulders from nearby streams. Long axes of the stones are gently inclined and parallel local drainage. Case-and-fill construction was used with smaller cobbles and pebbles used as fill. Pre-Muralla debris flows are indicated by meter-sized, angular boulders that were incorporated in-place into construction of the dam and are now exposed in breeches in the dam. Post-Muralla debris flows in the Chao Valley are indicated by meter-sized, angular boulders that now abut the retention dam.

  17. Post disaster resilience: Racially different correlates of depression symptoms among hurricane Katrina-Rita volunteers.

    PubMed

    Nicdao, Ethel G; Noel, La Tonya; Ai, Amy L; Plummer, Carol; Groff, Sara

    2013-01-01

    The present analyses examined the differential risks of and protective factors against depressive symptoms of African American and Non-Hispanic White American student volunteers, respectively after Hurricanes Katrina and Rita (H-KR). A total sample of 554 student volunteers were recruited from mental health professional programs at five universities located in the Deep South, namely areas severely impacted by H-KR during fall semester 2005. The response rate was 91% (n = 505). African American respondents (n = 299) and Non-Hispanic White Americans (n = 206) completed the survey questionnaires. Respondents retrospectively provided information on peritraumatic emotional reactions and previous trauma that were recalled by H-KR and H-KR stressors. African American respondents reported higher levels of depressive symptoms (65.2%) than their Non-Hispanic White counterparts (34.8%). Hierarchical regression analyses revealed that disaster related stressors affected African Americans (p < 0.001), but not Non-Hispanic Whites. However, African Americans who experienced peritraumatic positive emotions had lower depression levels. Lower rates of recollection of prior traumas during H-KR were reported by African American respondents, whereas previous trauma recollections predicted symptoms among Non-Hispanic White Americans (p < 0.05). Exhibiting more optimism had lower depression levels among Non-Hispanic White Americans. Peritraumatic negative emotion was the only shared risk for depressive symptoms of both groups. Findings underscore racially different levels of depressive symptoms that may contribute to varying degrees of resilience among student volunteers. Future research and practice may address these racial differences by understanding the risk factors for depressive symptoms to develop appropriate interventions for racial groups, and cultivating the protective factors that contribute to resilience from traumatic experiences.

  18. Assessing the Relationship Between Mental Distress and Tobacco Use in Post-Katrina and Rita Louisiana.

    PubMed

    Mukherjee, Snigdha; Canterberry, Melanie; Yore, Jennifer B; Ledford, Edward Cannon; Carton, Thomas W

    2017-08-24

    The relationship between mental health status and smoking is complicated and often confounded by bi-directionality, yet most research on this relationship assumes exogeneity. The goal of this article is to implement an instrumental variable approach to (1) test the exogeneity assumption and (2) report on the association between mental health status and smoking post-disaster. This analysis utilizes the 2006 and 2007 Louisiana Behavioral Risk Factor Surveillance Survey to examine the link between mental distress and smoking in areas affected by Hurricanes Katrina and Rita. Residence in a hurricane-affected parish (county) was used as an instrumental variable for mental distress. Just over 22% of the sample resided in a hurricane-affected parish. Residents of hurricane-affected parishes were significantly more likely to report occasional and frequent mental distress. Residence in a hurricane-affected parish was not significantly associated with smoking status. With residence established as a salient instrumental variable for mental distress, the exogeneity assumption was tested and confirmed in this sample. A dose-response relationship existed between mental distress and smoking, with smoking prevalence increasing directly (and non-linearly) with mental distress. In this sample, the relationship between mental distress and smoking status was exogenous and followed a dose-response relationship, suggesting that the disasters did not result in an uptake of smoking initiation, but that the higher amounts of mental distress may lead to increased use among smokers. The findings suggest that tobacco control programs should devise unique strategies to address mentally distressed populations.

  19. Kinematic structure of convective-scale elements in the rainbands of Hurricanes Katrina and Rita (2005)

    NASA Astrophysics Data System (ADS)

    Hence, Deanna A.; Houze, Robert A.

    2008-08-01

    Airborne Doppler radar data collected during the Hurricane Rainband and Intensity Change Experiment (RAINEX) show the convective-scale air motions embedded in the principal rainbands of hurricanes Katrina and Rita. These embedded convective cells have overturning updrafts and low-level downdrafts (originating at 2-4 km) that enter the rainband on its radially outward side and cross over each other within the rainband as well as a strong downdraft emanating from upper levels (6+ km) on the radially inward side. These vertical motion structures repeat from one convective cell to another along each rainband. The resulting net vertical mass transport is upward in the upwind portion of the band and greatest in the middle sector of the principal rainband, where the updraft motions contribute generally to an increase of potential vorticity below the 3-4 km level. Because the convective cells in the middle sector are systematically located radially just inside the secondary horizontal wind maximum (SHWM), the local increase in vorticity implied by the convective mass transport is manifest locally as an increase in the strength of the SHWM at midlevels (˜4 km). The overturning updrafts of the convective cells tilt, stretch, and vertically transport vorticity such that the convergence of the vertical flux of vorticity strengthens the vorticity anomaly associated with the SHWM. This process could strengthen the SHWM by several meters per second per hour, and may explain how high wave number convective-scale features can influence a low wave number feature such as the principal rainband, and subsequently influence the primary vortex.

  20. Promoting mental health recovery after hurricanes Katrina and Rita: what can be done at what cost.

    PubMed

    Schoenbaum, Michael; Butler, Brittany; Kataoka, Sheryl; Norquist, Grayson; Springgate, Benjamin; Sullivan, Greer; Duan, Naihua; Kessler, Ronald C; Wells, Kenneth

    2009-08-01

    Concerns about mental health recovery persist after the 2005 Gulf storms. We propose a recovery model and estimate costs and outcomes. To estimate the costs and outcomes of enhanced mental health response to large-scale disasters using the 2005 Gulf storms as a case study. Decision analysis using state-transition Markov models for 6-month periods from 7 to 30 months after disasters. Simulated movements between health states were based on probabilities drawn from the clinical literature and expert input. A total of 117 counties/parishes across Louisiana, Mississippi, Alabama, and Texas that the Federal Emergency Management Agency designated as eligible for individual relief following hurricanes Katrina and Rita. Hypothetical cohort, based on the size and characteristics of the population affected by the Gulf storms. Intervention Enhanced mental health care consisting of evidence-based screening, assessment, treatment, and care coordination. Morbidity in 6-month episodes of mild/moderate or severe mental health problems through 30 months after the disasters; units of service (eg, office visits, prescriptions, hospital nights); intervention costs; and use of human resources. Full implementation would cost $1133 per capita, or more than $12.5 billion for the affected population, and yield 94.8% to 96.1% recovered by 30 months, but exceed available provider capacity. Partial implementation would lower costs and recovery proportionately. Evidence-based mental health response is feasible, but requires targeted resources, increased provider capacity, and advanced planning.

  1. Regeneration of coastal marsh vegetation impacted by hurricanes Katrina and Rita

    USGS Publications Warehouse

    Middleton, B.A.

    2009-01-01

    The dynamics of plant regeneration via seed and vegetative spread in coastal wetlands dictate the nature of community reassembly that takes place after hurricanes or sea level rise. The objectives of my project were to evaluate the potential effects of saltwater intrusion and flooding of Hurricanes Katrina and Rita on seedling regeneration in coastal wetlands of the Gulf Coast. Specifically I tested hypotheses to determine for species in fresh, brackish and salt marshes of the Gulf Coast if 1) the pattern of seed germination and seedling recruitment differed with distance from the shoreline, and 2) seed germination and seedling recruitment for various species were reduced in higher levels of water depth and salinity. Regarding Hypothesis 1, seedling densities increased with distance from the shoreline in fresh and brackish water marshes while decreasing with distance from the shoreline in salt marshes. Also to test Hypothesis 1, I used a greenhouse seed bank assay to examine seed germination from seed banks collected at distances from the shoreline in response to various water depths and salinity levels using a nested factorial design. For all marsh types, the influence of water level and salinity on seed germination shifted with distance from the shoreline (i.e., three way interaction of the main effects of distance nested within site, water depth, and salinity). Data from the seed bank assay were also used to test Hypothesis 2. The regeneration of species from fresh, brackish, and salt marshes were reduced in conditions of high salinity and/or water, so that following hurricanes or sea level rise, seedling regeneration could be reduced. Among the species of these coastal marshes, there was some flexibility of response, so that at least some species were able to germinate in either high or low salinity. Salt marshes had a few fresher marsh species in the seed bank that would not germinate without a period of fresh water input (e.g., Sagittaria lancifolia) as well

  2. A review of the incidence and coincidence of uterine and mammary tumors in Wistar and Sprague-Dawley rats based on the RITA database and the role of prolactin.

    PubMed

    Harleman, Johannes H; Hargreaves, Adam; Andersson, Håkan; Kirk, Sarah

    2012-08-01

    Wistar rats are frequently selected for use in carcinogenicity studies because of their advantageous survival rate, which is more favorable than other strains such as the Sprague-Dawley (SD) strain. Uterine and mammary tumors are relatively common spontaneous neoplasms of both strains. We examined the incidence and coincidence of uterine tumors and mammary tumors in control animals of both strains within the RITA database. There was a strong inverse relationship between these tumor types in Wistar rats (p < .001). A less strong relationship was present in SD rats (p = .057). This association is likely to be related to prolactin. A short review of the role of prolactin in rats is given. These results are also discussed in the background of nonspecific toxicity at high dose levels in carcinogenicity studies above MTD levels resulting in reduction in body weights of >10%.

  3. Usefulness of the admission electrocardiogram to predict long-term outcomes after non-ST-elevation acute coronary syndrome (from the FRISC II, ICTUS, and RITA-3 [FIR] Trials).

    PubMed

    Damman, Peter; Holmvang, Lene; Tijssen, Jan G P; Lagerqvist, Bo; Clayton, Tim C; Pocock, Stuart J; Windhausen, Fons; Hirsch, Alexander; Fox, Keith A A; Wallentin, Lars; de Winter, Robbert J

    2012-01-01

    The aim of this study was to evaluate the independent prognostic value of qualitative and quantitative admission electrocardiographic (ECG) analysis regarding long-term outcomes after non-ST-segment elevation acute coronary syndromes (NSTE-ACS). From the Fragmin and Fast Revascularization During Instability in Coronary Artery Disease (FRISC II), Invasive Versus Conservative Treatment in Unstable Coronary Syndromes (ICTUS), and Randomized Intervention Trial of Unstable Angina 3 (RITA-3) patient-pooled database, 5,420 patients with NSTE-ACS with qualitative ECG data, of whom 2,901 had quantitative data, were included in this analysis. The main outcome was 5-year cardiovascular death or myocardial infarction. Hazard ratios (HRs) were calculated with Cox regression models, and adjustments were made for established outcome predictors. The additional discriminative value was assessed with the category-less net reclassification improvement and integrated discrimination improvement indexes. In the 5,420 patients, the presence of ST-segment depression (≥1 mm; adjusted HR 1.43, 95% confidence interval [CI] 1.25 to 1.63) and left bundle branch block (adjusted HR 1.64, 95% CI 1.18 to 2.28) were independently associated with long-term cardiovascular death or myocardial infarction. Risk increases were short and long term. On quantitative ECG analysis, cumulative ST-segment depression (≥5 mm; adjusted HR 1.34, 95% CI 1.05 to 1.70), the presence of left bundle branch block (adjusted HR 2.15, 95% CI 1.36 to 3.40) or ≥6 leads with inverse T waves (adjusted HR 1.22, 95% CI 0.97 to 1.55) was independently associated with long-term outcomes. No interaction was observed with treatment strategy. No improvements in net reclassification improvement and integrated discrimination improvement were observed after the addition of quantitative characteristics to a model including qualitative characteristics. In conclusion, in the FRISC II, ICTUS, and RITA-3 NSTE-ACS patient-pooled data set

  4. Riems influenza a typing array (RITA): An RT-qPCR-based low density array for subtyping avian and mammalian influenza a viruses.

    PubMed

    Hoffmann, Bernd; Hoffmann, Donata; Henritzi, Dinah; Beer, Martin; Harder, Timm C

    2016-06-03

    Rapid and sensitive diagnostic approaches are of the utmost importance for the detection of humans and animals infected by specific influenza virus subtype(s). Cascade-like diagnostics starting with the use of pan-influenza assays and subsequent subtyping devices are normally used. Here, we demonstrated a novel low density array combining 32 TaqMan(®) real-time RT-PCR systems in parallel for the specific detection of the haemagglutinin (HA) and neuraminidase (NA) subtypes of avian and porcine hosts. The sensitivity of the newly developed system was compared with that of the pan-influenza assay, and the specificity of all RT-qPCRs was examined using a broad panel of 404 different influenza A virus isolates representing 45 different subtypes. Furthermore, we analysed the performance of the RT-qPCR assays with diagnostic samples obtained from wild birds and swine. Due to the open format of the array, adaptations to detect newly emerging influenza A virus strains can easily be integrated. The RITA array represents a competitive, fast and sensitive subtyping tool that requires neither new machinery nor additional training of staff in a lab where RT-qPCR is already established.

  5. 27 CFR 9.80 - York Mountain.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Paso de Robles southwest 6.0 miles to where the boundary joins Santa Rita Creek; (3) Turn right at Santa Rita Creek and follow the creek 5 miles to where the waters of Dover Canyon and Santa Rita Creek...

  6. Sleep deprivation and adverse health effects in United States Coast Guard responders to Hurricanes Katrina and Rita.

    PubMed

    Bergan, Timothy; Thomas, Dana; Schwartz, Erica; McKibben, Jodi; Rusiecki, Jennifer

    2015-12-01

    Disaster responders are increasingly called upon to assist in various natural and manmade disasters. A critical safety concern for this population is sleep deprivation; however, there are limited published data regarding sleep deprivation and disaster responder safety. We expanded upon a cross-sectional study of 2695 United States Coast Guard personnel who responded to Hurricanes Katrina and Rita. Data were collected via survey on self-reported timing and location of deployment, missions performed, health effects, medical treatment sought, average nightly sleep, and other lifestyle variables. We created a 4-level sleep deprivation metric based on both average nightly reported sleep (d5hours; >5hours) and length of deployment (d2weeks; >2weeks) to examine the association between sustained sleep deprivation and illnesses, injuries, and symptoms using logistic regression to calculate odds ratios (ORs) and 95% confidence intervals. The strongest, statistically significant positive ORs for the highest sleep deprivation category compared with the least sleep-deprived category were for mental health and neurologic effects, specifically depression (OR=6.76), difficulty concentrating (OR=8.33), and confusion (OR=11.34), and for dehydration (OR=9.0). Injuries most strongly associated with sleep deprivation were twists, sprains, and strains (OR=6.20). Most health outcomes evaluated had monotonically increasing ORs with increasing sleep deprivation, and P tests for trend were statistically significant. Agencies deploying disaster responders should understand the risks incurred to their personnel by sustained sleep deprivation. Improved planning of response efforts to disasters can reduce the potential for sleep deprivation and lead to decreased morbidity in disaster responders. Published by Elsevier Inc.

  7. 75 FR 48549 - Surety Bond Guarantee Program; Size Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... the Presidentially- declared disaster areas resulting from the 2005 Hurricanes Katrina, Rita or Wilma... services in the Presidentially-declared disaster areas resulting from Hurricanes Katrina, Rita or Wilma... areas resulting from the 2005 Hurricanes Katrina, Rita or Wilma. Compliance With Executive Orders 12866...

  8. 75 FR 19609 - Newspapers Used for Publication of Legal Notices in the Southwestern Region, Which Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ... Mexico. Rita Blanca National Grassland in Cimarron County, Oklahoma Notices published in:-- ``Boise City News'', Boise City, Oklahoma. Rita Blanca National Grassland in Dallam County, Texas Notices published...'', Clayton, New Mexico. Rita Blanca National Grassland in Cimarron County, Oklahoma published in:--``Boise...

  9. 78 FR 43968 - Agency Information Collection; Activity Under OMB Review; Passenger Origin-Destination Survey Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-22

    ... RITA 2008-0002] Agency Information Collection; Activity Under OMB Review; Passenger Origin-Destination Survey Report AGENCY: Research & Innovative Technology Administration (RITA), Bureau of Transportation..., Office of Airline Information, RTS-42, Room E34-441, RITA, BTS, 1200 New Jersey Avenue SE., Washington...

  10. 76 FR 75866 - Newspapers Used for Publication of Legal Notices in the Southwestern Region, Which Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... in: --``Union County Leader'', Clayton, New Mexico. Rita Blanca National Grassland in Cimarron County, Oklahoma notices published in:--``Boise City News'', Boise City, Oklahoma. Rita Blanca National Grassland... Mexico published in:--``Union County Leader'', Clayton, New Mexico. Rita Blanca National Grassland in...

  11. 75 FR 3274 - Agency Information Collection; Activity Under OMB Review; Passenger Origin-Destination Survey Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... RITA 2008-0002] Agency Information Collection; Activity Under OMB Review; Passenger Origin-Destination Survey Report AGENCY: Research & Innovative Technology Administration (RITA), Bureau of Transportation... Airline Information, RTS-42, Room E34-409, RITA, BTS, 1200 New Jersey Avenue, SE., Washington, DC 20590...

  12. 78 FR 32645 - Notification of a Public Teleconference of the Great Lakes Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... wishing further information regarding this teleconference may contact Rita Cestaric, Designated Federal Officer (DFO), GLAB, by telephone at (312) 886-6815 or email at cestaric.rita@epa.gov . General... speaker, subject to the number of people wanting to comment. Interested parties should contact Rita...

  13. 78 FR 59018 - Notification of a Public Teleconference of the Great Lakes Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... further information regarding this teleconference may contact Rita Cestaric, Designated Federal Officer (DFO), GLAB, by telephone at (312) 886-6815 or email at cestaric.rita@epa.gov . General information on... parties should contact Rita Cestaric, DFO, in writing (preferably via email) at the contact information...

  14. 77 FR 31432 - Agency Information Collection; Activity Under OMB Review; Report of Extension of Credit to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... AGENCY: Research & Innovative Technology Administration (RITA), Bureau of Transportation Statistics (BTS... Gorham, Office of Airline Information, RTS-42, Room E34, RITA, BTS, 1200 New Jersey Avenue SE... Management and Budget, 715-17th Street NW., Washington, DC 20503, Attention RITA Desk Officer. SUPPLEMENTARY...

  15. 75 FR 4097 - Notice of Proposed Information Collection for Public Comment: Tracking the Use of CDBG Homeowner...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    ... information and proposed use: In August, September, and October 2005, Hurricanes Katrina, Rita, and Wilma... hurricanes Katrina and Rita (Louisiana, Mississippi, and Texas) and to identify the most important factors... Katrina and Rita rebuilding efforts during FY 2011. The study findings also will help the Federal...

  16. 78 FR 49950 - Dispute Resolution Pilot Program for Public Assistance Appeals

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... Public Assistance Determinations Related to Hurricanes Katrina and Rita (Disasters DR-1603, DR-1604, DR... between the Hurricanes Katrina and Rita arbitration process and the DRPP include, but are not limited to: (1) The Hurricanes Katrina and Rita arbitration process is limited to just Hurricanes Katrina and...

  17. 77 FR 36231 - Americans With Disabilities Act (ADA) and Architectural Barriers Act (ABA) Accessibility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ... Agency (FEMA) in the aftermath of Hurricanes Katrina and Rita raised issues regarding the application of... limitations. Emergency transportable housing units provided in the aftermath of Hurricanes Katrina and Rita... transportable housing units that were raised in the aftermath of Hurricanes Katrina and Rita. The committee...

  18. 78 FR 13077 - Notice of Proposed Information Collection for Public Comment; Section 901 Implementation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... PHAs in federally declared disaster areas as a result of Hurricanes Katrina and Rita to combine their... Act) to assist families who were displaced by Hurricane Katrina or Rita. HUD determined that this... most heavily affected by Hurricanes Katrina and Rita the flexibility to combine funds through calendar...

  19. Characterization of flood sediments from Hurricanes Katrina and Rita and potential implications for human health and the environment: Chapter 7I in Science and the storms-the USGS response to the hurricanes of 2005

    USGS Publications Warehouse

    Plumlee, Geoffrey S.; Foreman, William T.; Griffin, Dale W.; Lovelace, John K.; Meeker, Gregory P.; Demas, Charles R.

    2007-01-01

    The flooding in the greater New Orleans, La., area that resulted from Hurricanes Katrina and Rita in August and September 2005 left behind accumulations of sediments up to many centimeters thick on streets, lawns, parking lots, and other flat surfaces (fig. 1). During the flood dewatering and subsequent cleanup, there were concerns that these sediments might contain pathogens and chemical contaminants that would pose a health risk to emergency responders, cleanup workers, and local residents who came into contact with the wet sediments or inhaled dusts generated from dried sediments. In response to these concerns, U.S. Geological Survey (USGS) scientists and colleagues characterized the potential environmental and health hazards of hurricane flood sediments from the greater New Orleans and Slidell, La., area.

  20. RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53–Fbxw7 pathway

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Haihe; Yang, Zhanchun; Liu, Chunbo

    2014-11-07

    Highlights: • RITA overexpression increased protein expression of p53 and Fbxw7 and downregulated the expression of cyclin D1, cyclin E, CDK2, Hes-1 and NF-κB p65. • RITA can significantly inhibit the in vitro growth of SMMC7721 and HepG2 cells. • RITA exerts tumor-suppressive effects in hepatocarcinogenesis through induction of G0/G1 cell cycle arrest and apoptosis and suggest a therapeutic application of RITA in HCC. - Abstract: Aberrant Notch signaling is observed in human hepatocellular carcinoma (HCC) and has been associated with the modulation of cell growth. However, the role of Notch signaling in HCC and its underlying mechanism remain elusive.more » RBP-J-interacting and tubulin-associated (RITA) mediates the nuclear export of RBP-J to tubulin fibers and downregulates Notch-mediated transcription. In this study, we found that RITA overexpression increased protein expression of p53 and Fbxw7 and downregulated the expression of cyclin D1, cyclin E, CDK2, Hes-1 and NF-κB p65. These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells. Our findings indicate that RITA exerts tumor-suppressive effects in hepatocarcinogenesis through induction of G0/G1 cell cycle arrest and apoptosis and suggest a therapeutic application of RITA in HCC.« less

  1. Early clinical and angiographic outcome of the pedicled right internal thoracic artery graft to the left anterior descending artery.

    PubMed

    Al-Ruzzeh, Sharif; George, Shane; Bustami, Mahmoud; Nakamura, Koki; Ilsley, Charles; Amrani, Mohamed

    2002-05-01

    The left internal thoracic artery (LITA) graft to the left anterior descending (LAD) artery became the gold standard graft in coronary surgery. Subsequently, the right internal thoracic artery (RITA) graft was increasingly used. However, there is still some debate about the optimal way of using this conduit. The aim of the present study was to assess our experience in grafting the pedicled RITA graft to LAD in 212 consecutive patients. The records of 212 consecutive patients who underwent isolated coronary artery bypass grafting with the pedicled RITA graft to the LAD artery at Harefield Hospital between January 1998 and May 2001 were retrospectively reviewed. We approached the last 35 consecutive patients to obtain an angiographic control group. All 35 patients (16.5%) consented and, before discharge, underwent angiography to look at the quality of anastomoses and the patency of grafts. Successful catheterization and engagement of the RITA grafts was performed in 32 patients. Angiography showed that 32/32 (100%) of the RITA grafts were widely patent with excellent flow. The distal anastomoses of these RITA grafts were also satisfactory. There were no deaths among the study patients. Our results show that the use of the pedicled RITA graft to the LAD artery provides a good early clinical and angiographic outcome, and suggests that the pedicled RITA graft to the LAD artery is a good alternative to the pedicled LITA graft to the LAD artery.

  2. New Orleans before and after Hurricanes Katrina/Rita: a quasi-experiment of the association between soil lead and children's blood lead.

    PubMed

    Zahran, Sammy; Mielke, Howard W; Gonzales, Christopher R; Powell, Eric T; Weiler, Stephan

    2010-06-15

    Prior to Hurricanes Katrina and Rita (HKR), significant associations were noted between soil lead (SL) and blood lead (BL) in New Orleans. Engineering failure of New Orleans levees and canal walls after HKR set the stage for a quasi-experiment to evaluate BL responses by 13 306 children to reductions in SL. High density soil surveying conducted in 46 census tracts before HKR was repeated after the flood. Paired t test results show that SL decreased from 328.54 to 203.33 mg/kg post-HKR (t = 3.296, p < or = 0.01). Decreases in SL are associated with declines in children's BL response (r = 0.308, p < or = 0.05). When SL decreased at least 1%, median children's BL declined 1.55 microg/dL. Declines in median BL are largest in census tracts with > or =50% decrease in SL. Also individual BL in children was predicted as a function of SL, adjusting for age, year of observation, and depth of flood waters. At the individual scale, BL decreased significantly in post-HKR as a function of SL, with BL decreases ranging from b = -1.20 to -1.65 microg/dL, depending on the decline of SL and whether children were born in the post-HKR period. Our results support policy to improve soil conditions for children.

  3. USGS environmental characterization of flood sediments left in the New Orleans area after Hurricanes Katrina and Rita, 2005--Progress Report

    USGS Publications Warehouse

    Plumlee, Geoffrey S.; Meeker, Gregory P.; Lovelace, John K.; Rosenbauer, Robert J.; Lamothe, Paul J.; Furlong, Edward T.; Demas, Charles R.

    2006-01-01

    Introduction: The flooding in the greater New Orleans area that resulted from Hurricanes Katrina and Rita in September, 2005, left behind accumulations of sediments up to many centimeters thick on streets, lawns, parking lots, and other flat surfaces. These flood sediment deposits have been the focus of extensive study by the US Environmental Protection Agency (EPA) and Louisiana Department of Environmental Quality (LDEQ) due to concerns that the sediments may contain elevated levels of heavy metals, organic contaminants, and microbes. The U.S. Geological Survey (USGS) is characterizing a limited number of flood sediment samples that were collected on September 15-16 and October 6-7, 2005, from the greater New Orleans area by personnel from the USGS Louisiana Water Science Center in Baton Rouge. Small samples (< 3 pints each) of wet to dry flood sediment were collected from 11 localities around downtown New Orleans on September 15, 2005, and two large samples (40 pints each) of wet flood sediment were collected from the Chalmette area on September 16. Twelve additional samples (8-10 pints each) were collected from New Orleans, Slidell, Rigolets, and Violet on October 6 and 7. The USGS characterization studies of these flood sediments are designed to produce data and interpretations regarding how the sediments and any contained contaminants may respond to environmental processes. This information will be of use to cleanup managers and DoI/USGS scientists assessing environmental impacts of the hurricanes and subsequent cleanup activities.

  4. 10-Year Mortality Outcome of a Routine Invasive Strategy Versus a Selective Invasive Strategy in Non-ST-Segment Elevation Acute Coronary Syndrome: The British Heart Foundation RITA-3 Randomized Trial.

    PubMed

    Henderson, Robert A; Jarvis, Christopher; Clayton, Tim; Pocock, Stuart J; Fox, Keith A A

    2015-08-04

    The RITA-3 (Third Randomised Intervention Treatment of Angina) trial compared outcomes of a routine early invasive strategy (coronary arteriography and myocardial revascularization, as clinically indicated) to those of a selective invasive strategy (coronary arteriography for recurrent ischemia only) in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). At a median of 5 years' follow-up, the routine invasive strategy was associated with a 24% reduction in the odds of all-cause mortality. This study reports 10-year follow-up outcomes of the randomized cohort to determine the impact of a routine invasive strategy on longer-term mortality. We randomized 1,810 patients with NSTEACS to receive routine invasive or selective invasive strategies. All randomized patients had annual follow-up visits up to 5 years, and mortality was documented thereafter using data from the Office of National Statistics. Over 10 years, there were no differences in mortality between the 2 groups (all-cause deaths in 225 [25.1%] vs. 232 patients [25.4%]: p = 0.94; and cardiovascular deaths in 135 [15.1%] vs. 147 patients [16.1%]: p = 0.65 in the routine invasive and selective invasive groups, respectively). Multivariate analysis identified several independent predictors of 10-year mortality: age, previous myocardial infarction, heart failure, smoking status, diabetes, heart rate, and ST-segment depression. A modified post-discharge Global Registry of Acute Coronary Events (GRACE) score was used to calculate an individual risk score for each patient and to form low-risk, medium-risk, and high-risk groups. Risk of death within 10 years varied markedly from 14.4 % in the low-risk group to 56.2% in the high-risk group. This mortality trend did not depend on the assigned treatment strategy. The advantage of reduced mortality of routine early invasive strategy seen at 5 years was attenuated during later follow-up, with no evidence of a difference in outcome at 10 years

  5. First manned submersible dives on the East Pacific Rise at 21°N (project RITA): general results

    USGS Publications Warehouse

    Francheteau, Jean; Needham, H.D.; Choukroune, P.; Juteau, Tierre; Seguret, M.; Ballard, Richard D.; Fox, P.J.; Normark, W.R.; Carranza, A.; Cordoba, D.; Guerrero, J.; Rangin, C.

    1981-01-01

    A submersible study has been conducted in February–March 1978 at the axis of the East Pacific Rise near 21°N. The expedition CYAMEX, the first submersible program to be conducted on the East Pacific Rise, is part of the French-American-Mexican project RITA (Rivera-Tamayo), a 3-year study devoted to detailed geological and geophysical investigations of the East Pacific Rise Crest. On the basis of the 15 dives made by CYANA in the axial area of the Rise, a morphological and tectonic zonation can be established for this moderately-fast spreading center. A narrow, 0.6 to 1.2 km wide zone of extrusion (zone 1), dominated by young lava flows, is flanked by a highly fissured and faulted zone of extension (zone 2) with a width of 1 to 2 km. Further out, zone 3 is dominated by outward tilted blocks bounded by inward-facing fault scarps. Active or recent faults extend up to 12 km from the axis of extrusion of the East Pacific Rise. This represents the first determination from direct field evidence of the width of active tectonism associated with an accreting plate boundary. Massive sulfide deposits, made principally of zinc, copper and iron, were found close to the axis of the Rise. Other signs of the intense hydrothermal activity included the discovery of benthic fauna of gian size similar to that found at the axis of the Galapagos Rift. We emphasize the cyclic character of the volcanicity. The main characteristics of the geology of this segment of the East Pacific Rise can be explained by the thermal structure at depth below this moderately-fast spreading center. The geological observations are compatible with the existence of a shallow magma reservoir centered at the axis of the Rise with a half-width of the order of 10 km.

  6. Skin disorders among construction workers following Hurricane Katrina and Hurricane Rita: an outbreak investigation in New Orleans, Louisiana.

    PubMed

    Noe, Rebecca; Cohen, Adam L; Lederman, Edith; Gould, L Hannah; Alsdurf, Hannah; Vranken, Peter; Ratard, Rauol; Morgan, Juliette; Norton, Scott A; Mott, Joshua

    2007-11-01

    To determine the extent and scope of the outbreak of skin eruptions, to identify the causes of the acute skin diseases, to identify risk factors for the conditions, and to reduce the dermatologic morbidity among workers repairing buildings damaged by Hurricane Katrina and Hurricane Rita. Retrospective cohort study. Military base in New Orleans, Louisiana. Civilian construction workers living and working at a New Orleans military base between August 30, 2005, and October 3, 2005. Living conditions were mainly wooden huts and tents with limited sanitation facilities. Survey of risk factors, physical examination, skin biopsy specimens, and environmental investigation of the occupational and domiciliary exposures. Of 136 workers, 58 reported rash, yielding an attack rate of 42.6%. The following 4 clinical entities were diagnosed among 41 workers who had a physical examination (some had >1 diagnosis): 27 (65.9%) having papular urticaria, 8 (19.5%) having bacterial folliculitis, 6 (14.6%) having fiberglass dermatitis, and 2 (4.9%) having brachioradial photodermatitis. All diagnoses except brachioradial photodermatitis were confirmed by histopathologic examination. After adjusting for race/ethnicity and occupation, sleeping in previously flooded huts was statistically significantly (adjusted odds ratio, 20.4; 95% confidence interval, 5.9-70.2) associated with developing papular urticaria, the most common cause of rash in this cluster. We identified 4 distinct clinical entities, although most workers were diagnosed as having papular urticaria. Huts previously flooded as a result of the hurricanes and used for sleeping may have harbored mites, a likely source of papular urticaria. To reduce the morbidity of hurricane-related skin diseases, we suggest avoiding flooded areas, fumigating with an acaricide, and wearing protective clothing.

  7. The Randomised Intervention Treatment of Angina (RITA) Trial protocol: a long term study of coronary angioplasty and coronary artery bypass surgery in patients with angina.

    PubMed Central

    Henderson, R A

    1989-01-01

    The Randomised Intervention Treatment of Angina (RITA) Trial is a prospective, randomised study to compare the short term and long term effects of percutaneous transluminal coronary angioplasty and coronary artery bypass surgery. During the study a register of patients undergoing coronary arteriography at the fourteen participating centres is being maintained to assess the overall context of patient recruitment. Patients with arteriographically proven coronary artery disease are considered for the trial if the participating cardiologist and surgeon agree that equivalent revascularisation could be achieved by either treatment method. Patients who satisfy the trial entry criteria are randomised to treatment by coronary angioplasty or coronary artery bypass surgery, with prospective stratification into groups with one, two, or three treatment vessels. Randomisation implies an intention to treat the patient by the assigned procedure and the analysis of long term results will include all randomised cases. The trial will recruit at least 1000 patients who will be followed for five years. The major trial end points include death, new myocardial infarction, and new coronary angioplasty or coronary artery bypass procedures. Other outcome measures include symptom and employment status, quality of life, exercise tolerance, and left ventricular function. PMID:2486557

  8. Effects of age on long-term outcomes after a routine invasive or selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes: a collaborative analysis of individual data from the FRISC II - ICTUS - RITA-3 (FIR) trials.

    PubMed

    Damman, Peter; Clayton, Tim; Wallentin, Lars; Lagerqvist, Bo; Fox, Keith A A; Hirsch, Alexander; Windhausen, Fons; Swahn, Eva; Pocock, Stuart J; Tijssen, Jan G P; de Winter, Robbert J

    2012-02-01

    To perform a patient-pooled analysis of a routine invasive versus a selective invasive strategy in elderly patients with non-ST segment elevation acute coronary syndrome. A meta-analysis was performed of patient-pooled data from the FRISC II-ICTUS-RITA-3 (FIR) studies. (Un)adjusted HRs were calculated by Cox regression, with adjustments for variables associated with age and outcomes. The main outcome was 5-year cardiovascular death or myocardial infarction (MI) following routine invasive versus selective invasive management. Regarding the 5-year composite of cardiovascular death or MI, the routine invasive strategy was associated with a lower hazard in patients aged 65-74 years (HR 0.72, 95% CI 0.58 to 0.90) and those aged ≥75 years (HR 0.71, 95% CI 0.55 to 0.91), but not in those aged <65 years (HR 1.11, 95% CI 0.90 to 1.38), p=0.001 for interaction between treatment strategy and age. The interaction was driven by an excess of early MIs in patients <65 years of age; there was no heterogeneity between age groups concerning cardiovascular death. The benefits were smaller for women than for men (p=0.009 for interaction). After adjustment for other clinical risk factors the HRs remained similar. The current analysis of the FIR dataset shows that the long-term benefit of the routine invasive strategy over the selective invasive strategy is attenuated in younger patients aged <65 years and in women by the increased risk of early events which seem to have no consequences for long-term cardiovascular mortality. No other clinical risk factors were able to identify patients with differential responses to a routine invasive strategy. Trial registration http://www.controlled-trials.com/ISRCTN82153174 (ICTUS), http://www.controlled-trials.com/ISRCTN07752711 (RITA-3).

  9. Looking for the Silver Lining: Benefit Finding after Hurricanes Katrina and Rita in Middle-Aged, Older, and Oldest-Old Adults.

    PubMed

    Stanko, Katie E; Cherry, Katie E; Ryker, Kyle S; Mughal, Farra; Marks, Loren D; Brown, Jennifer Silva; Gendusa, Patricia F; Sullivan, Marisa C; Bruner, John; Welsh, David A; Su, L Joseph; Jazwinski, S Michal

    2015-09-01

    Looking for potentially positive outcomes is one way that people cope with stressful events. In two studies, we examined perceived "silver linings" after the 2005 Hurricanes Katrina and Rita among indirectly affected adults. In Study 1, middle-aged (ages 47-64 years), older (ages 65-89 years), and oldest-old (ages 90-95 years) adults in the Louisiana Healthy Aging Study (LHAS) responded to an open-ended question on perceived silver linings in a longitudinal assessment carried out during the immediate impact (1 to 4 months after landfall) and post-disaster recovery phase (6 to 14 months post-storm). Qualitative grounded theory methods were employed to analyze these narrative data. Team-based coding yielded three core themes: (1) learning experience and better preparedness for future disasters, (2) having improved cities (Baton Rouge and New Orleans), and (3) an increase in "Good Samaritan" acts such as strangers helping one another. Responses were similar across age groups, although older adults were the least likely to report positive outcomes. Study 2 was a conceptual replication using a different sample of adults (ages 31 to 82 years) tested at least five years after the storms. A learning experience and preparedness core theme replicated Study 1's findings while improved social cohesion amongst family and friends emerged as a new core theme in Study 2. These data indicate that identifying lessons learned and potentially positive outcomes are psychological reactions that may facilitate post-disaster coping and foster resilience for indirectly affected adults in the years after disaster.

  10. Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1

    PubMed Central

    Ahmed, A; Yang, J; Maya-Mendoza, A; Jackson, D A; Ashcroft, M

    2011-01-01

    We have recently shown that induction of the p53 tumour suppressor protein by the small-molecule RITA (reactivation of p53 and induction of tumour cell apoptosis; 2,5-bis(5-hydroxymethyl-2-thienyl)furan) inhibits hypoxia-inducible factor-1α and vascular endothelial growth factor expression in vivo and induces p53-dependent tumour cell apoptosis in normoxia and hypoxia. Here, we demonstrate that RITA activates the canonical ataxia telangiectasia mutated/ataxia telangiectasia and Rad3-related DNA damage response pathway. Interestingly, phosphorylation of checkpoint kinase (CHK)-1 induced in response to RITA was influenced by p53 status. We found that induction of p53, phosphorylated CHK-1 and γH2AX proteins was significantly increased in S-phase. Furthermore, we found that RITA stalled replication fork elongation, prolonged S-phase progression and induced DNA damage in p53 positive cells. Although CHK-1 knockdown did not significantly affect p53-dependent DNA damage or apoptosis induced by RITA, it did block the ability for DNA integrity to be maintained during the immediate response to RITA. These data reveal the existence of a novel p53-dependent S-phase DNA maintenance checkpoint involving CHK-1. PMID:21593792

  11. An interpretation of the 1996 aeromagnetic data for the Santa Cruz basin, Tumacacori Mountains, Santa Rita Mountains, and Patagonia Mountains, south-central Arizona

    USGS Publications Warehouse

    Gettings, Mark E.

    2002-01-01

    High resolution aeromagnetic survey data flown at 250 m above the terrain and 250 m line spacing over the Santa Cruz Valley and the surrounding Tumacacori, Patagonia, and Santa Rita Mountains has been interpreted by correlation of the magnetic anomaly field and various derivative maps with geologic maps. Measurements of in-situ magnetic properties of several of the map units determined whether or not mapped lithologies were responsible for observed anomalies. Correlation of the magnetic anomaly field with mapped geology shows that numerous map units of volcanic and intrusive rocks from Jurassic Middle Tertiary in age are reversely polarized, some of which have not been previously reported. Trends derived from the magnetic anomaly data correlate closely with structures from major tectonic events in the geologic history of the area including Triassic-Jurassic crustal accretion and magmatism, Laramide magmatism and tectonism, northeast-southwest Mid-Tertiary extension, and east-west Basin and Range extension. Application of two textural measures to the magnetic anomaly data, number of peaks and troughs per km (a measure of roughness) and Euclidean length per km (a measure of amplitude), delineated areas of consistent magnetic anomaly texture. These measures were successful at the delineation of areas of consistent magnetic lithology both on the surface and in the subsurface beneath basin fill. Several areas of basement prospective for mineral resources beneath basin fill were identified.

  12. Magmatic anhydrite and calcite in the ore-forming quartz-monzodiorite magma at Santa Rita, New Mexico (USA): genetic constraints on porphyry-Cu mineralization

    NASA Astrophysics Data System (ADS)

    Audétat, A.; Pettke, T.; Dolejš, D.

    2004-02-01

    A quartz-monzodioritic dike associated with the porphyry-Cu mineralized stock at Santa Rita, NM, has been studied to constrain physico-chemical factors ( P, T, fO 2, and volatile content) responsible for mineralization. The dike contains a low-variance mineral assemblage of amphibole, plagioclase (An 30-50), quartz, biotite, sphene, magnetite, and apatite, plus anhydrite and calcite preserved as primary inclusions within the major phenocryst phases. Petrographic relationships demonstrate that anhydrite originally was abundant in the form of phenocrysts (1-2 vol.%), but later was replaced by either quartz or calcite. Hornblende-plagioclase thermobarometry suggests that several magmas were involved in the formation of the quartz-monzodiorite, with one magma having ascended directly from ≥14 km depth. Rapid magma ascent is supported by the presence of intact calcite inclusions within quartz phenocrysts. The assemblage quartz+sphene+magnetite+Mg-rich amphibole in the quartz-monzodiorite constrains magmatic oxygen fugacity at log fO 2>NNO+1, in agreement with the presence of magmatic anhydrite and a lack of magmatic sulfides. The same reasoning generally applies for rocks hosting porphyry-Cu deposits, seemingly speaking against a major role of magmatic sulfides in the formation of such mineralizations. There is increasing evidence, however, that magmatic sulfides play an important role in earlier stages of porphyry-Cu evolution, the record of which is often obliterated by later processes.

  13. EAARL coastal topography and imagery–Western Louisiana, post-Hurricane Rita, 2005: First surface

    USGS Publications Warehouse

    Bonisteel-Cormier, Jamie M.; Wright, Wayne C.; Fredericks, Alexandra M.; Klipp, Emily S.; Nagle, Doug B.; Sallenger, Asbury H.; Brock, John C.

    2013-01-01

    These remotely sensed, geographically referenced color-infrared (CIR) imagery and elevation measurements of lidar-derived first-surface (FS) topography datasets were produced by the U.S. Geological Survey (USGS), St. Petersburg Coastal and Marine Science Center, St. Petersburg, Florida, and the National Aeronautics and Space Administration (NASA), Wallops Flight Facility, Virginia. This project provides highly detailed and accurate datasets of a portion of the Louisiana coastline beachface, acquired post-Hurricane Rita on September 27-28 and October 2, 2005. The datasets are made available for use as a management tool to research scientists and natural-resource managers. An innovative airborne lidar instrument originally developed at the National Aeronautics and Space Administration (NASA) Wallops Flight Facility, and known as the Experimental Advanced Airborne Research Lidar (EAARL), was used during data acquisition. The EAARL system is a raster-scanning, waveform-resolving, green-wavelength (532-nanometer) lidar designed to map near-shore bathymetry, topography, and vegetation structure simultaneously. The EAARL sensor suite includes the raster-scanning, water-penetrating full-waveform adaptive lidar, a down-looking red-green-blue (RGB) digital camera, a high-resolution multispectral color-infrared (CIR) camera, two precision dual-frequency kinematic carrier-phase GPS receivers, and an integrated miniature digital inertial measurement unit, which provide for sub-meter georeferencing of each laser sample. The nominal EAARL platform is a twin-engine Cessna 310 aircraft, but the instrument may be deployed on a range of light aircraft. A single pilot, a lidar operator, and a data analyst constitute the crew for most survey operations. This sensor has the potential to make significant contributions in measuring sub-aerial and submarine coastal topography within cross-environmental surveys. Elevation measurements were collected over the survey area using the EAARL

  14. 75 FR 25284 - Tracking the Use of CDBG Homeowners and Small Landlords Disaster Assistance Grants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... affected by hurricanes Katrina and Rita (Louisiana, Mississippi, and Texas) and identify the most important... affected by hurricanes Katrina and Rita (Louisiana, Mississippi, and Texas) and identify the most important...

  15. Toxic trace element assessment for soils/sediments deposited during Hurricanes Katrina and Rita from southern Louisiana, USA: a sequential extraction analysis.

    PubMed

    Shi, Honglan; Witt, Emitt C; Shu, Shi; Su, Tingzhi; Wang, Jianmin; Adams, Craig

    2010-07-01

    Analysis of soil/sediment samples collected in the southern Louisiana, USA, region three weeks after Hurricanes Katrina and Rita passed was performed using sequential extraction procedures to determine the origin, mode of occurrence, biological availability, mobilization, and transport of trace elements in the environment. Five fractions: exchangeable, bound to carbonates, bound to iron (Fe)-manganese (Mn) oxides, bound to organic matter, and residual, were subsequently extracted. The toxic trace elements Pb, As, V, Cr, Cu, and Cd were analyzed in each fraction, together with Fe in 51 soil/sediment samples. Results indicated that Pb and As were at relatively high concentrations in many of the soil/sediment samples. Because the forms in which Pb and As are present tend to be highly mobile under naturally occurring environmental conditions, these two compounds pose an increased health concern.Vanadium and Cr were mostly associated with the crystal line nonmobile residual fraction. A large portion of the Cu was associated with organic matter and residual fraction. Cadmium concentrations were low in all soil/sediment samples analyzed and most of this element tended to be associated with the mobile fractions. An average of 21% of the Fe was found in the Fe-Mn oxide fraction, indicating that a substantial part of the Fe was in an oxidized form. The significance of the overall finding of the present study indicated that the high concentrations and high availabilities of the potentially toxic trace elements As and Pb may impact the environment and human health in southern Louisiana and, in particular, the New Orleans area. Copyright (c) 2010 SETAC.

  16. 76 FR 55393 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... temporary housing units deployed in the Gulf Coast region following hurricanes Katrina and Rita. The title... housing units following hurricanes Katrina and Rita, and who were potentially exposed to higher levels of...

  17. 78 FR 76161 - Notice of Regulatory Waiver Requests Granted for the Third Quarter of Calendar Year 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... during Hurricanes Katrina and Rita in 2005, and Gustav in 2008. Nature of Requirements: The HOME... Hurricanes Katrina, and Rita in 2005, and Gustav, in 2008. Contact: Virginia Sardone, Director, Office of...

  18. 78 FR 4968 - Privacy Act of 1974, Computer Matching Program-U.S. Small Business Administration and U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... hurricanes Katrina and Rita, and referred 67,023 of those registrations to SBA as potential duplicates. Excluding the Katrina and Rita disasters, DHS/FEMA received 7,070,068 registrations from 1998-2009, and...

  19. 75 FR 35847 - Privacy Act of 1974, Computer Matching Program-U.S. Small Business Administration and U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... response to hurricanes Katrina and Rita, and referred 67,023 of those registrations to SBA as potential duplicates. Excluding the Katrina and Rita disasters, DHS/FEMA received 7,070,068 registrations from 1998...

  20. U.S. DOT support to the president's innovation agenda : briefing and discussion.

    DOT National Transportation Integrated Search

    2009-07-27

    1. Introduction and Overview of DOT Organization, Mission, and Goals)(Peter Appel, RITA) : 2. White House Perspective on Innovation (Tom Kalil, OSTP) : 3. Briefings on Highlighted Innovations : -Intelligent Transportation Systems (Shelley Row, RITA) ...

  1. A New Interactive Screening Test for Autism Spectrum Disorders in Toddlers.

    PubMed

    Choueiri, Roula; Wagner, Sheldon

    2015-08-01

    To develop a clinically valid interactive level 2 screening assessment for autism spectrum disorders (ASD) in toddlers that is brief, easily administered, and scored by clinicians. We describe the development, training, standardization, and validation of the Rapid Interactive Screening Test for Autism in Toddlers (RITA-T) with ASD-specific diagnostic instruments. The RITA-T can be administered and scored in 10 minutes. We studied the validity of the RITA-T to distinguish between toddlers with ASD from toddlers with developmental delay (DD)/non-ASD in an early childhood clinic. We also evaluated the test's performance in toddlers with no developmental concerns. We identified a cutoff score based on sensitivity, specificity, and positive predictive value of the RITA-T that best differentiates between ASD and DD/non-ASD. A total of 61 toddlers were enrolled. RITA-T scores were correlated with ASD-specific diagnostic tools (r = 0.79; P < .01) and ASD clinical diagnoses (r = 0.77; P < .01). Mean scores were significantly different in subjects with ASD, those with DD/non-ASD, and those with no developmental concerns (20.8 vs 13 vs 10.6, respectively; P < .0001). At a cutoff score of >14 , the RITA-T had a sensitivity of 1.00, specificity of 0.84, and positive predictive value of 0.88 for identifying ASD risk in a high-risk group. The RITA-T is a promising new level 2 interactive screening tool for improving the early identification of ASD in toddlers in general pediatric and early intervention settings and allowing access to treatment. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Is the mid-term outcome of free right internal thoracic artery with a proximal anastomosis modification inferior to in situ right internal thoracic artery?

    PubMed

    Yoshizumi, Tomo; Ito, Toshiaki; Maekawa, Atsuo; Sunada, Masatoshi; Wakai, Kenii; Usui, Akihiko; Ueda, Yuichi

    2012-08-01

    We investigated the mid-term results of free right internal thoracic artery (RITA) grafts used in an aorto-coronary fashion with a modified proximal anastomosis. The subjects were 214 patients who underwent coronary artery bypass grafting with anastomosis to the left circumflex arteries using the RITA as a free graft (Group A: 158 patients) or an in situ graft (Group B: 56 patients). In Group A, the proximal end of the free RITA was anastomosed onto the ascending aorta interposing free graft tissue or to part of its own tissue as a cuff. The number of RITA anastomoses was 1.38 ± 0.50 in Group A and 1.04 ± 0.19 in Group B (P < 0.001). The relationship between perioperative variables and mid-term outcomes was assessed using Cox proportional hazard models. Survival was not associated with the way the RITA graft was performed (Hazard Ratio 5.26, 95 % CI 0.52-53.1, P = 0.159), however, the number of cardiac events was decreased in Group A (Hazard Ratio 2.55, 95 % CI 1.03-6.33, P = 0.043). The graft patency was evaluated in 187 of 214 patients, and at 1, 3 and 5 years was 97.0, 97.0 and 97.0 % in Group A, and 97.9, 92.5 and 80.5 % in Group B (P = 0.378), respectively. By modifying the proximal anastomosis of the free RITA, cardiac events may be decreased, while survival and graft patency comparable with in situ RITA can be obtained, and a significantly larger number of targets can be revascularized.

  3. 76 FR 6508 - Data Collection Available for Public Comments and Recommendations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... parishes/ counties that were Presidential declared disaster area as a results of Hurricanes Katrina or Rita...: Applicants requesting an SBA loan for Katrina or Rita. Form Number's: 2276 A, B, C, 2281, 2282. Annual...

  4. 77 FR 18306 - Agency Information Collection; Activity Under OMB Review; Airline Service Quality Performance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... DEPARTMENT OF TRANSPORTATION Research & Innovative Technology Administration [Docket ID No. RITA... Performance AGENCY: Research & Innovative Technology Administration (RITA), Bureau of Transportation... travelers information concerning the on-time performance history of flights that they are considering...

  5. 78 FR 26801 - Notice of Submission of Proposed Information Collection to OMB; Section 901 Notice of Intent and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-08

    ... Congress extended this funding flexibility to address the impacts of Hurricanes Rita and Katrina. Some PHAs... all ninety-six PHAs in the areas impacted by Hurricanes Katrina and Rita would opt to use it. A later...

  6. Volcanic facies architecture of an intra-arc strike-slip basin, Santa Rita Mountains, Southern Arizona

    NASA Astrophysics Data System (ADS)

    Busby, Cathy J.; Bassett, Kari N.

    2007-09-01

    The three-dimensional arrangement of volcanic deposits in strike-slip basins is not only the product of volcanic processes, but also of tectonic processes. We use a strike-slip basin within the Jurassic arc of southern Arizona (Santa Rita Glance Conglomerate) to construct a facies model for a strike-slip basin dominated by volcanism. This model is applicable to releasing-bend strike-slip basins, bounded on one side by a curved and dipping strike-slip fault, and on the other by curved normal faults. Numerous, very deep unconformities are formed during localized uplift in the basin as it passes through smaller restraining bends along the strike-slip fault. In our facies model, the basin fill thins and volcanism decreases markedly away from the master strike-slip fault (“deep” end), where subsidence is greatest, toward the basin-bounding normal faults (“shallow” end). Talus cone-alluvial fan deposits are largely restricted to the master fault-proximal (deep) end of the basin. Volcanic centers are sited along the master fault and along splays of it within the master fault-proximal (deep) end of the basin. To a lesser degree, volcanic centers also form along the curved faults that form structural highs between sub-basins and those that bound the distal ends of the basin. Abundant volcanism along the master fault and its splays kept the deep (master fault-proximal) end of the basin overfilled, so that it could not provide accommodation for reworked tuffs and extrabasinally-sourced ignimbrites that dominate the shallow (underfilled) end of the basin. This pattern of basin fill contrasts markedly with that of nonvolcanic strike-slip basins on transform margins, where clastic sedimentation commonly cannot keep pace with subsidence in the master fault-proximal end. Volcanic and subvolcanic rocks in the strike-slip basin largely record polygenetic (explosive and effusive) small-volume eruptions from many vents in the complexly faulted basin, referred to here as multi

  7. Concept of operations for the US-75 integrated corridor in Dallas, Texas

    DOT National Transportation Integrated Search

    2008-04-30

    This Concept of Operations (Con Ops) for the US-75 Integrated Corridor Management (ICM) Program has been developed as part of the Federal Highway Administration, the Federal Transit Administration, and RITA (FHWA/FTA/RITA) Integrated Corridor Managem...

  8. Remagnetization of Jurassic volcanic rocks in the Santa Rita and Patagonia Mountains, Arizona: Implications for North American apparent polar wander

    NASA Astrophysics Data System (ADS)

    Hagstrum, Jonathan T.

    1994-08-01

    Paleomagnetic poles for the Jurassic Corral Canyon sequence and Glance Conglomerate in southern Arizona have been used to construct apparent polar wander (APW) paths for the North American plate, but they are controversial and conflict with higher-latitude poles from New England. Lower Jurassic dacites and ash flow tuffs of the Mount Wrightson Formation in the Santa Rita Mountains were initially sampled to provide an additionnal paleopole for southern Arizona. These rocks, however,have a predominantly reversed-polarity characteristic magnetization (in situ, I = -47 deg, D = 154 deg, alpha(sub 95) = 9 deg) which is statistically indistinguishable from that for the nearby latest Cretaceous Elephant Head pluton (I = -48 deg, D = 165 deg, alpha(sub 95) = 8 deg). Although magnetizations of both polarities are observed in the ash flow tuffs, they are mostly carried by hematite, and dual polarity components are observed within some specimens. Moreover, widespread mineralization and a K-Ar age of approx. 67 Ma for altered rocks of the Mount Wrightson Formation imply that these rocks were subjected to a prolonged episode (greater than one polarity interval) of low-temperature alteration and remagnetization. Hematite is also the dominant remanence carrier in most of the Corral Canyon sequence, and its predominantly normal-polarity direction (in situ, I = 51 deg, D = 326 deg, alpha(sub 95) = 9 deg) is indistinguishable from that for the nearby Patagonia Granodiorite (I = 49 deg, D = 342 deg, alpha(sub 95) = 8 deg). Rocks of the Corral Canyon sequence therefore are likely remagnetized as well. Problems also exist with the Glance Conglomerate pole. These rocks are situated within a caldera structure and have been potassium metasomatized. This potassic alteration could have occurred shortly after emplacement or at a later time, postdeformation. The low-latitude Jurassic APW path for North America and J-2 cusp therefore are not well supported and may need revision.

  9. 77 FR 26824 - Agency Information Collection; Activity Under OMB Review; Reporting Required for International...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... RITA 2008-0002] Agency Information Collection; Activity Under OMB Review; Reporting Required for International Civil Aviation Organization (ICAO) AGENCY: Research & Innovative Technology Administration (RITA... Reduction Act of 1995 (44 U.S.C. 3501 et seq.), this notice announces that the Information Collection...

  10. 75 FR 53007 - Gulf Opportunity Pilot Loan Program (GO Loan Pilot)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... Presidentially-declared disaster areas resulting from Hurricanes Katrina and Rita as well as the further... impacted by Hurricanes Katrina and Rita. Under this unique initiative, SBA provides its full (85%) guaranty.../ counties that have been Presidentially-declared as disaster areas resulting from Hurricanes Katrina and...

  11. 76 FR 60960 - Gulf Opportunity Pilot Loan Program (GO Loan Pilot)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... resulting from Hurricanes Katrina and Rita, as well as the further devastation by the April 2011 severe... financial assistance to businesses located in those communities severely impacted by Hurricanes Katrina and... Presidentially-declared as disaster areas resulting from Hurricanes Katrina and Rita, plus any contiguous...

  12. 76 FR 17867 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    .... Proposed Project Registration of Individuals Displaced by the Hurricanes Katrina and Rita (Pilot Project... and Brief Description On August 29, 2005, Hurricane Katrina made landfall on the coast of the Gulf of.... history. Also occurring in 2005, Hurricane Rita was the fourth-most intense Atlantic hurricane ever...

  13. 75 FR 2800 - Special Community Disaster Loans Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ... in the Gulf Coast region who received Special Community Disaster Loans following Hurricanes Katrina.... After the catastrophic damage caused by Hurricanes Katrina and Rita in 2005, communities in Louisiana...'s, (44 CFR 206.370-206.377), only apply to communities affected by Hurricanes Katrina and Rita. The...

  14. 75 FR 9244 - Fungibility Plan and Follow-Up Reporting To Implement Section 901 on Voucher Funds for Displaced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ...-Up Reporting To Implement Section 901 on Voucher Funds for Displaced Hurricane Katrina and Rita... comments on the subject proposal. Eligible PHAs in areas most heavily impacted by Hurricanes Katrina and... purposes to Aid Formerly Assisted Families Displaced by Hurricanes Katrina and Rita. OMB Approval Number...

  15. 78 FR 18445 - Historically Black College and University (HBCU) Capital Financing Program; Modification of Terms...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... conditions of loans made to the following four institutions affected by Hurricanes Katrina and Rita under the... affected by Hurricanes Katrina and Rita. The special loan terms included, but were not limited to... Federal Government. The three agencies have determined that, due to the impact of Hurricanes Katrina and...

  16. Computer-Assisted Reading Intervention in a Secondary School: An Evaluation Study.

    ERIC Educational Resources Information Center

    Lynch, Lisa; Fawcett, Angela J.; Nicolson, Roderick I.

    2000-01-01

    RITA (Reader's Interactive Teaching Assistant) is a computer-based literacy support system that assists, rather than replaces, the teacher in providing support tailored to each child's profile of reading attainments. This study evaluated the effectiveness of RITA in secondary school with 8 children having very seriously disadvantaged literacy…

  17. 77 FR 6801 - Agency for Toxic Substances and Disease Registry; Agency Forms Undergoing Paperwork Reduction Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-09

    ... Individuals Displaced by the Hurricanes Katrina and Rita (Pilot Project)--New--Agency for Toxic Substances and... Description On August 29, 2005, Hurricane Katrina made landfall on the coast of the Gulf of Mexico near New... Hurricanes Katrina and Rita. In addition, comparisons of prevalence rates of health outcomes obtained through...

  18. Mathematical Modeling of E6-p53 interactions in Cervical Cancer

    PubMed

    Khattak, Faryal; Haseeb, Muhammad; Fazal, Sahar; Bhatti, A I; Ullah, Mukhtar

    2017-04-01

    Background: Cervical cancer is the third most common cancer in women throughout the world. The human papillomavirus (HPV) E6 viral protein plays an essential role in proteasomal degradation of the cancer suppressant protein p53. As a result, p53 negative regulation and apoptosis relevant activities are abrogated, facilitating development of cervical cancer. Methods: A mathematical model of E6-p53 interactions was developed using mathematical laws. In-silico simulations were carried out on CellDesigner and as a test case the small molecule drug RITA was considered for its ability to rescue the functions of tumor suppressor p53 by inhibiting E6 mediated proteasomal degradation. Results: Using a computational model we scrutinized how p53 responds to RITA, and chemical reactions of this small molecule drug were incorporated to perceive the full effects. The evolved strategy allowed the p53 response and rescue of its tumor suppressor function to be delineated, RITA being found to block p53 interactions with E6 associated proteins. Conclusion: We could develop a model of E6-p53 interactions with incorporation of actions of the small molecule drug RITA. Suppression of E6 associated proteins by RITA induces accumulation of tumor suppressant p53. Using CellDesigner to encode the model ensured that it can be easily modified and extended as more data become available. This strategy should play an effective role in the development of therapies against cancer. Creative Commons Attribution License

  19. Mathematical Modeling of E6-p53 interactions in Cervical Cancer

    PubMed Central

    Khattak, Faryal; Haseeb, Muhammad; Fazal, Sahar; Bhatti, AI; Ullah, Mukhtar

    2017-01-01

    Background: Cervical cancer is the third most common cancer in women throughout the world. The human papillomavirus (HPV) E6 viral protein plays an essential role in proteasomal degradation of the cancer suppressant protein p53. As a result, p53 negative regulation and apoptosis relevant activities are abrogated, facilitating development of cervical cancer. Methods: A mathematical model of E6-p53 interactions was developed using mathematical laws. In-silico simulations were carried out on CellDesigner and as a test case the small molecule drug RITA was considered for its ability to rescue the functions of tumor suppressor p53 by inhibiting E6 mediated proteasomal degradation. Results: Using a computational model we scrutinized how p53 responds to RITA, and chemical reactions of this small molecule drug were incorporated to perceive the full effects. The evolved strategy allowed the p53 response and rescue of its tumor suppressor function to be delineated, RITA being found to block p53 interactions with E6 associated proteins. Conclusion: We could develop a model of E6-p53 interactions with incorporation of actions of the small molecule drug RITA. Suppression of E6 associated proteins by RITA induces accumulation of tumor suppressant p53. Using CellDesigner to encode the model ensured that it can be easily modified and extended as more data become available. This strategy should play an effective role in the development of therapies against cancer. PMID:28547941

  20. Bacteriological water quality in and around Lake Pontchartrain following Hurricanes Katrina and Rita: Chapter 7H in Science and the storms-the USGS response to the hurricanes of 2005

    USGS Publications Warehouse

    Demcheck, Dennis K.; Stoeckel, Donald M.; Bushon, Rebecca N.; Blehert, David S.; Hippe, Daniel J.

    2007-01-01

    Following the Louisiana landfalls of Katrina on August 29 and Rita on September 24, 2005, the local population and the American public were concerned about the effects the hurricanes might have on water quality in Lake Pontchartrain. The lake is a major recreational resource for the region and an important fishery. Contamination carried by the storm surge—along with runoff and water pumped from flooded areas of New Orleans—was considered a serious threat to the water body. The USGS, in collaboration with the LDEQ, monitored the sanitary quality of water at 22 sites in and around Lake Pontchartrain, La., for 3 consecutive weeks from September 13 to 29, 2005 (fig. 1). A subsequent multipleagency survey of 30 sites within Lake Pontchartrain was undertaken by the U.S. Environmental Protection Agency (EPA), the USGS, and the National Oceanic and Atmospheric Administration during the week of October 11–14, 2005, to evaluate the effects of the hurricanes and overall levels of fecal contamination on the water quality of the lake (see Heitmuller and Perez, this volume). In addition, the EPA monitored fecal-indicator concentrations at a variety of sites in New Orleans, surrounding areas, and the Mississippi River between September 3 and October 22, 2005 (U.S. Environmental Protection Agency, 2006). This article describes fecal-indicator bacteria concentration results collected by USGS in the context of other existing data.

  1. Analysis by early angiography of right internal thoracic artery grafting via the transverse sinus : predictors of graft failure.

    PubMed

    Ura, M; Sakata, R; Nakayama, Y; Arai, Y; Oshima, S; Noda, K

    2000-02-15

    There has been debate regarding whether technically demanding right internal thoracic artery (RITA) grafting via the transverse sinus can be extensively applied to patients in high-risk groups, such as patients with a small body size, elderly patients, and woman with relatively smaller coronary artery and internal thoracic artery (ITA) diameters. Of the 1456 patients who underwent isolated coronary artery bypass grafting between January 1989 and December 1998 at Kumamoto Central Hospital, 393 patients (mean age, 62.4+/-9.0 years) with the RITA anastomosed to the major branches of the circumflex artery were studied. Left ITA grafting was performed in 384 patients, and in 369, the in situ left ITA was anastomosed to the left anterior descending coronary artery using standard methods. Early postoperative angiography was performed in 381 patients. The RITA was occluded in 4 patients, and string-like artery and significant stenosis were present in 11 and 7 patients, respectively; RITA graft patency was thus 94.1%. Of the preoperative variables and angiographic data, simple and multiple logistic regression analyses identified decreased severity of native stenosis, diffuse sclerosis of native vessels, and residual side branches of the ITA as independent predictors of nonfunctional grafts. The method of ITA grafting did not influence the patency of the graft. The excellent patency rate demonstrated by this study, the largest angiographic study to date of RITA grafting via the transverse sinus, indicates that this technique can provide reliable revascularization of the left ventricle and that it has the potential to be applied to a wide variety of patients with diseased circumflex arteries.

  2. Viral Load Criteria and Threshold Optimization to Improve HIV Incidence Assay Characteristics - A CEPHIA Analysis

    PubMed Central

    Kassanjee, Reshma; Pilcher, Christopher D; Busch, Michael P; Murphy, Gary; Facente, Shelley N; Keating, Sheila M; Mckinney, Elaine; Marson, Kara; Price, Matthew A; Martin, Jeffrey N; Little, Susan J; Hecht, Frederick M; Kallas, Esper G; Welte, Alex

    2016-01-01

    Objective Assays for classifying HIV infections as ‘recent’ or ‘non-recent’ for incidence surveillance fail to simultaneously achieve large mean durations of ‘recent’ infection (MDRIs) and low ‘false-recent’ rates (FRRs), particularly in virally suppressed persons. The potential for optimizing recent infection testing algorithms (RITAs), by introducing viral load criteria and tuning thresholds used to dichotomize quantitative measures, is explored. Design The Consortium for the Evaluation and Performance of HIV Incidence Assays characterized over 2000 possible RITAs constructed from seven assays (LAg, BED, Less-sensitive Vitros, Vitros Avidity, BioRad Avidity, Architect Avidity and Geenius) applied to 2500 diverse specimens. Methods MDRIs were estimated using regression, and FRRs as observed ‘recent’ proportions, in various specimen sets. Context-specific FRRs were estimated for hypothetical scenarios. FRRs were made directly comparable by constructing RITAs with the same MDRI through the tuning of thresholds. RITA utility was summarized by the precision of incidence estimation. Results All assays produce high FRRs amongst treated subjects and elite controllers (10%-80%). Viral load testing reduces FRRs, but diminishes MDRIs. Context-specific FRRs vary substantially by scenario – BioRad Avidity and LAg provided the lowest FRRs and highest incidence precision in scenarios considered. Conclusions The introduction of a low viral load threshold provides crucial improvements in RITAs. However, it does not eliminate non-zero FRRs, and MDRIs must be consistently estimated. The tuning of thresholds is essential for comparing and optimizing the use of assays. The translation of directly measured FRRs into context-specific FRRs critically affects their magnitudes and our understanding of the utility of assays. PMID:27454561

  3. Using Instrument Simulators and a Satellite Database to Evaluate Microphysical Assumptions in High-Resolution Simulations of Hurricane Rita

    NASA Astrophysics Data System (ADS)

    Hristova-Veleva, S. M.; Chao, Y.; Chau, A. H.; Haddad, Z. S.; Knosp, B.; Lambrigtsen, B.; Li, P.; Martin, J. M.; Poulsen, W. L.; Rodriguez, E.; Stiles, B. W.; Turk, J.; Vu, Q.

    2009-12-01

    Improving forecasting of hurricane intensity remains a significant challenge for the research and operational communities. Many factors determine a tropical cyclone’s intensity. Ultimately, though, intensity is dependent on the magnitude and distribution of the latent heating that accompanies the hydrometeor production during the convective process. Hence, the microphysical processes and their representation in hurricane models are of crucial importance for accurately simulating hurricane intensity and evolution. The accurate modeling of the microphysical processes becomes increasingly important when running high-resolution models that should properly reflect the convective processes in the hurricane eyewall. There are many microphysical parameterizations available today. However, evaluating their performance and selecting the most representative ones remains a challenge. Several field campaigns were focused on collecting in situ microphysical observations to help distinguish between different modeling approaches and improve on the most promising ones. However, these point measurements cannot adequately reflect the space and time correlations characteristic of the convective processes. An alternative approach to evaluating microphysical assumptions is to use multi-parameter remote sensing observations of the 3D storm structure and evolution. In doing so, we could compare modeled to retrieved geophysical parameters. The satellite retrievals, however, carry their own uncertainty. To increase the fidelity of the microphysical evaluation results, we can use instrument simulators to produce satellite observables from the model fields and compare to the observed. This presentation will illustrate how instrument simulators can be used to discriminate between different microphysical assumptions. We will compare and contrast the members of high-resolution ensemble WRF model simulations of Hurricane Rita (2005), each member reflecting different microphysical assumptions

  4. Second internal thoracic artery versus radial artery in coronary artery bypass grafting: a long-term, propensity score-matched follow-up study.

    PubMed

    Ruttmann, Elfriede; Fischler, Nikolaus; Sakic, Adel; Chevtchik, Orest; Alber, Hannes; Schistek, Roland; Ulmer, Hanno; Grimm, Michael

    2011-09-20

    The best second arterial conduit for multiple arterial revascularization (MAR) is still a matter of debate. Previous studies on the benefit of either using the radial artery (RA) or the right internal thoracic artery (RITA) in coronary artery bypass grafting are not conclusive. The aim of our study was to compare the perioperative and long-term outcome of either RA or RITA grafts as second conduits for MAR. A consecutive series of 1001 patients undergoing first nonemergent coronary artery bypass grafting receiving either RA or RITA as second graft for MAR between 2001 and 2010 were studied. There were 277 patients receiving a RITA and 724 patients receiving a RA in addition to a left internal thoracic artery (LITA). Concomitant saphenous vein grafts (SVG) were grafted in addition as necessary. Propensity score-matched analysis was performed to compare the 2 groups, bilateral ITA±SVG (BITA±SVG group) and the LITA+RA±SVG group relative to overall survival and major adverse cardiac and cerebrovascular events-free survival. Hazard ratios and their 95% confidence intervals were estimated by COX regression stratified on matched pairs. The incidence of perioperative major adverse cardiac and cerebrovascular events was significantly lower in the BITA±SVG group (1.4% versus 7.6%, P<0.001). Overall survival (hazard ratio 0.23; 95% confidence interval 0.066-0.81; P=0.022) and major adverse cardiac and cerebrovascular events-free survival (hazard ratio 0.18; 95% confidence interval 0.08-0.42; P<0.001) were significantly better in the BITA±SVG group compared to the LITA+RA±SVG group. The results of our study provide strong evidence for the superiority of a RITA graft compared to RA as a second conduit in MAR.

  5. Public Talks and Science Listens: A Community-Based Participatory Approach to Characterizing Environmental Health Risk Perceptions and Assessing Recovery Needs in the Wake of Hurricanes Katrina and Rita

    PubMed Central

    Sullivan, J.; Parras, B.; St. Marie, R.; Subra, W.; Petronella, S.; Gorenstein, J.; Fuchs-Young, R.; Santa, R.K.; Chavarria, A.; Ward, J.; Diamond, P.

    2009-01-01

    In response to the human health threats stemming from Hurricanes Katrina and Rita, inter-disciplinary working groups representing P30-funded Centers of the National Institute Environmental Health Sciences were created to assess threats posed by mold, harmful alga blooms, chemical toxicants, and various infectious agents at selected sites throughout the hurricane impact zone. Because of proximity to impacted areas, UTMB NIEHS Center in Environmental Toxicology was charged with coordinating direct community outreach efforts, primarily in south Louisiana. In early October 2005, UTMB/NIEHS Center Community Outreach and Education Core, in collaboration with outreach counterparts at The University of Texas MD Anderson Cancer Center @ Smithville TX/Center for Research in Environmental Disease sent two groups into southern Louisiana. One group used Lafourche Parish as a base to deliver humanitarian aid and assess local needs for additional supplies during local recovery/reclamation. A second group, ranging through New Iberia, New Orleans, Chalmette, rural Terrebonne, Lafourche and Jefferson Parishes and Baton Rouge met with community environmental leaders, emergency personnel and local citizens to 1) sample public risk perceptions, 2) evaluate the scope and reach of ongoing risk communication efforts, and 3) determine how the NIEHS could best collaborate with local groups in environmental health research and local capacity building efforts. This scoping survey identified specific information gaps limiting efficacy of risk communication, produced a community “wish list” of potential collaborative research projects. The project provided useful heuristics for disaster response and management planning and a platform for future collaborative efforts in environmental health assessment and risk communication with local advocacy groups in south Terrebonne-Lafourche parishes. PMID:20508756

  6. Relativistically Induced Transparency Acceleration (RITA) - laser-plasma accelerated quasi-monoenergetic GeV ion-beams with existing lasers?

    NASA Astrophysics Data System (ADS)

    Sahai, Aakash A.

    2013-10-01

    laser's push is controlled by the electrostatic space-charge pull by the immobile background ions. In the rest-frame of the laser, the electrostatic-potential that the ions create to balance the ponderomotive force on e-s, scales as the effective vector potential, aplasma . This potential hill, due to snowplowed e-s, co-propagating with the rising laser can reflect protons and light-ions (Relativistically Induced Transparency Acceleration, RITA). Desired proton or light-ion energies can be achieved by controlling the velocity of the snowplow, which is shown to scale inversely with the rise-time of the laser (higher energies for shorter pulses) and directly with the scale-length of the plasma density gradient. Similar acceleration can be produced by controlling the increase of the laser frequency (Chirp Induced Transparency Acceleration, ChITA). Work supported by the National Science Foundation under NSF- PHY-0936278. Also, NSF-PHY-0936266 and NSF-PHY-0903039; the US Department of Energy under DEFC02-07ER41500, DE- FG02-92ER40727 and DE-FG52-09NA29552.

  7. Effect of hurricane paths on storm surge response at Tianjin, China

    NASA Astrophysics Data System (ADS)

    Feng, Xingru; Yin, Baoshu; Yang, Dezhou

    2012-06-01

    A hurricane induced storm surge simulation system was developed for Tianjin coast, which consists of a hurricane model and a storm surge model. The peak storm surge result of the simulation agreed well with that of the observation. Three observed paths (Rita, Mimie and WINNIE) and a hypothetical path (Rita2) were chosen as the selective hurricane paths according to their positions relative to Tianjin. The sensitivity of Tianjin storm surge to the four paths was investigated using the validated storm surge simulation system. Three groups of experiments were done. In group one, the models were forced by the wind field and air pressure; in group two and three the models were forced by the wind only and the air pressure only respectively. In the experiments, the hurricane moved with a fixed speed and an intensity of 50 year return period. The simulation results show that path of the type Rita2 is the easiest to cause storm surge disaster in Tianjin, and the effect of air pressure forcing is most evident for path of the type Rita in Tianjin storm surge process. The above conclusions were analyzed through the evolution of the wind fields and the air pressure distributions. Comparing the experiment results of Group one, two and three, it can be seen that the storm surge is mainly induced by the wind forcing and the nonlinear interaction between the effect of wind forcing and air pressure forcing on the storm surge tends to weaken the storm surge.

  8. Timing of angiography with a routine invasive strategy and long-term outcomes in non-ST-segment elevation acute coronary syndrome: a collaborative analysis of individual patient data from the FRISC II (Fragmin and Fast Revascularization During Instability in Coronary Artery Disease), ICTUS (Invasive Versus Conservative Treatment in Unstable Coronary Syndromes), and RITA-3 (Intervention Versus Conservative Treatment Strategy in Patients With Unstable Angina or Non-ST Elevation Myocardial Infarction) Trials.

    PubMed

    Damman, Peter; van Geloven, Nan; Wallentin, Lars; Lagerqvist, Bo; Fox, Keith A A; Clayton, Tim; Pocock, Stuart J; Hirsch, Alexander; Windhausen, Fons; Tijssen, Jan G P; de Winter, Robbert J

    2012-02-01

    This study sought to investigate long-term outcomes after early or delayed angiography in patients with non-ST-segment elevation acute coronary syndrome (nSTE-ACS) undergoing a routine invasive management. The optimal timing of angiography in patients with nSTE-ACS is currently a topic for debate. Long-term follow-up after early (within 2 days) angiography versus delayed (within 3 to 5 days) angiography was investigated in the FRISC-II (Fragmin and Fast Revascularization During Instability in Coronary Artery Disease), ICTUS (Invasive Versus Conservative Treatment in Unstable Coronary Syndromes), and RITA-3 (Intervention Versus Conservative Treatment Strategy in Patients With Unstable Angina or Non-ST Elevation Myocardial Infarction) (FIR) nSTE-ACS patient-pooled database. The main outcome was cardiovascular death or myocardial infarction up to 5-year follow-up. Hazard ratios (HR) were calculated with Cox regression models. Adjustments were made for the FIR risk score, study, and the propensity of receiving early angiography using inverse probability weighting. Of 2,721 patients originally randomized to the routine invasive arm, consisting of routine angiography and subsequent revascularization if suitable, 975 underwent early angiography and 1,141 delayed angiography. No difference was observed in 5-year cardiovascular death or myocardial infarction in unadjusted (HR: 1.06, 95% confidence interval [CI]: 0.79 to 1.42, p=0.61) and adjusted (HR: 0.93, 95% CI: 0.75 to 1.16, p=0.54) Cox regression models. In the FIR database of patients presenting with nSTE-ACS, the timing of angiography was not related to long-term cardiovascular mortality or myocardial infarction. (Invasive Versus Conservative Treatment in Unstable Coronary Syndromes [ICTUS]; ISRCTN82153174. Intervention Versus Conservative Treatment Strategy in Patients With Unstable Angina or Non-ST Elevation Myocardial Infarction [the Third Randomised Intervention Treatment of Angina Trials (RITA-3)]; ISRCTN

  9. CRISPR-Cas9-based target validation for p53-reactivating model compounds

    PubMed Central

    Wanzel, Michael; Vischedyk, Jonas B; Gittler, Miriam P; Gremke, Niklas; Seiz, Julia R; Hefter, Mirjam; Noack, Magdalena; Savai, Rajkumar; Mernberger, Marco; Charles, Joël P; Schneikert, Jean; Bretz, Anne Catherine; Nist, Andrea; Stiewe, Thorsten

    2015-01-01

    Inactivation of the p53 tumor suppressor by Mdm2 is one of the most frequent events in cancer, so compounds targeting the p53-Mdm2 interaction are promising for cancer therapy. Mechanisms conferring resistance to p53-reactivating compounds are largely unknown. Here we show using CRISPR-Cas9–based target validation in lung and colorectal cancer that the activity of nutlin, which blocks the p53-binding pocket of Mdm2, strictly depends on functional p53. In contrast, sensitivity to the drug RITA, which binds the Mdm2-interacting N terminus of p53, correlates with induction of DNA damage. Cells with primary or acquired RITA resistance display cross-resistance to DNA crosslinking compounds such as cisplatin and show increased DNA cross-link repair. Inhibition of FancD2 by RNA interference or pharmacological mTOR inhibitors restores RITA sensitivity. The therapeutic response to p53-reactivating compounds is therefore limited by compound-specific resistance mechanisms that can be resolved by CRISPR-Cas9-based target validation and should be considered when allocating patients to p53-reactivating treatments. PMID:26595461

  10. Radiofrequency ablation for hepatocellular carcinoma: a prospective comparison of four radiofrequency devices.

    PubMed

    Lin, Shi-Ming; Lin, Chen-Chun; Chen, Wei-Ting; Chen, Yi-Chen; Hsu, Chao-Wei

    2007-09-01

    To compare the effectiveness of ablation techniques for hepatocellular carcinoma (HCC) with the use of four radiofrequency (RF) devices. One hundred patients with 133 HCC lesions no larger than 4 cm were treated with one of four RF devices: RF 2000 (maximum power, 100 W) and RF 3000 generators (maximum power, 200 W) with LeVeen expandable electrodes with a maximum dimension of 3.5 cm or 4 cm, internally cooled single electrode with a thermal dimension of 3 cm, and a RITA RF generator with expandable electrodes with a maximum dimension of 5 cm. Numbers of RF sessions needed per HCC to achieve complete necrosis were 1.4 +/- 0.5 with the RF 2000 device and greater than 1.1 +/- 0.3 with the other three devices (P < .05). The RF 2000 device required a more interactive algorithm than the RF 3000 device. Session times per patient were 31.7 minutes +/- 13.2 in the RF 2000 group and longer than 16.6 minutes +/- 7.5 in the RF 3000 group, 28.3 minutes +/- 12 in the RITA device group, and 27.1 minutes +/- 12 with the internally cooled electrode device (P < .005 for RF 2000 vs other devices and for RF 3000 vs RITA or internally cooled electrode device). Complete necrosis and local tumor progression rates at 2 years in the RF 2000, RF 3000, RITA, and internally cooled electrode device groups were 91.1%, 97.1%, 96.7%, and 96.8% and 12%, 8%, 8.2%, and 8.3%, respectively (P = .37). Ablation with the RF 3000 device required a shorter time than the other three devices and required a less interactive algorithm than the RF 2000 device. However, complete necrosis and local tumor progression rates were similar among devices.

  11. 76 FR 26291 - Pesticide Products; Registration Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-06

    ..., spanish lime, starfruit, sugar apple, wax jambu, rambutan, and persimmon. Contact: Rita Kumar..., sweet; cotton; cucurbits; fruiting vegetables, field and greenhouse; grapes; hops; mint; pome fruit...

  12. Withholding nutrition on the conscious mentally disabled patient: a review and commentary.

    PubMed

    Veatch, Robert M

    2002-01-01

    A recent important and poorly publicized legal case in California raised the question of whether the wife of a severely mentally disabled man could intentionally withhold medically supplied nutrition from him on the grounds that it was no longer providing benefits. Rita L. Marker has published a detailed case report and analysis. The readers of the Newsletter on Ethics and Intellectual Disability should know about her analysis. A summary is presented here together with some observations about the issues the case raises. Readers are encouraged to consult the original article: Rita L. Marker, "Mental Disability and Death by Dehydration." National Catholic Bioethics Quarterly 2 (Spring 2002): 125-36. All quotations are from the Marker analysis.

  13. 77 FR 42735 - Appointments to the Medicare Payment Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ..., South Shore Hospital; Jack Hoadley, Ph.D., Research Professor, Health Policy Institute, Georgetown... Ford Health System; Rita Redberg, MD, Professor, Clinical Medicine, University of California at San...

  14. Motion of the plasma critical layer during relativistic-electron laser interaction with immobile and comoving ion plasma for ion accelerationa)

    NASA Astrophysics Data System (ADS)

    Sahai, Aakash A.

    2014-05-01

    We analyze the motion of the plasma critical layer by two different processes in the relativistic-electron laser-plasma interaction regime (a0>1). The differences are highlighted when the critical layer ions are stationary in contrast to when they move with it. Controlling the speed of the plasma critical layer in this regime is essential for creating low-β traveling acceleration structures of sufficient laser-excited potential for laser ion accelerators. In Relativistically Induced Transparency Acceleration (RITA) scheme, the heavy plasma-ions are fixed and only trace-density light-ions are accelerated. The relativistic critical layer and the acceleration structure move longitudinally forward by laser inducing transparency through apparent relativistic increase in electron mass. In the Radiation Pressure Acceleration (RPA) scheme, the whole plasma is longitudinally pushed forward under the action of the laser radiation pressure, possible only when plasma ions co-propagate with the laser front. In RPA, the acceleration structure velocity critically depends upon plasma-ion mass in addition to the laser intensity and plasma density. In RITA, mass of the heavy immobile plasma-ions does not affect the speed of the critical layer. Inertia of the bared immobile ions in RITA excites the charge separation potential, whereas RPA is not possible when ions are stationary.

  15. Motion of the plasma critical layer during relativistic-electron laser interaction with immobile and comoving ion plasma for ion acceleration

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sahai, Aakash A., E-mail: aakash.sahai@gmail.com

    2014-05-15

    We analyze the motion of the plasma critical layer by two different processes in the relativistic-electron laser-plasma interaction regime (a{sub 0}>1). The differences are highlighted when the critical layer ions are stationary in contrast to when they move with it. Controlling the speed of the plasma critical layer in this regime is essential for creating low-β traveling acceleration structures of sufficient laser-excited potential for laser ion accelerators. In Relativistically Induced Transparency Acceleration (RITA) scheme, the heavy plasma-ions are fixed and only trace-density light-ions are accelerated. The relativistic critical layer and the acceleration structure move longitudinally forward by laser inducing transparencymore » through apparent relativistic increase in electron mass. In the Radiation Pressure Acceleration (RPA) scheme, the whole plasma is longitudinally pushed forward under the action of the laser radiation pressure, possible only when plasma ions co-propagate with the laser front. In RPA, the acceleration structure velocity critically depends upon plasma-ion mass in addition to the laser intensity and plasma density. In RITA, mass of the heavy immobile plasma-ions does not affect the speed of the critical layer. Inertia of the bared immobile ions in RITA excites the charge separation potential, whereas RPA is not possible when ions are stationary.« less

  16. 76 FR 78007 - Ocean Transportation Intermediary License; Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    ..., (Qualifying Individual), Ruba Hindi, Member, Application Type: New OFF License. Kemka USA Limited Liability Company (NVO & OFF), 421 Lucy Court, South Plainfield, NJ 07080, Officer: Hsiang (Rita) Y. Hsiao, Member...

  17. 77 FR 74492 - Federal Property Suitable as Facilities To Assist the Homeless

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... 20405, (202) 501-0084; HHS: Ms. Theresa M. Rita, Chief, Real Property Branch, Department of Health and... Maxwell AFB Maxwell AL Landholding Agency: Air Force Property Number: 18201240021 Status: Underutilized...

  18. 77 FR 32089 - Establishment of the Great Lakes Advisory Board (GLAB)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ... restoration policy; long term goals and objectives for Great Lakes protection and restoration; and annual... congressional committees and the Library of Congress. FOR FURTHER INFORMATION CONTACT: Rita Cestaric, U.S...

  19. 78 FR 56912 - Notice of Regulatory Waiver Requests Granted for the Second Quarter of Calendar Year 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ... the devastation caused by Hurricanes Katrina, Rita and Gustav. The City is located within a declared..., 2013. Reason Waived: The SJBPHA requested a waiver due to severe property damage from Hurricane Isaac...

  20. 78 FR 70567 - Nationwide Use of High Frequency and Ultra High Frequency Active SONAR Technology; Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ... such as: The attacks of September 11, 2001; natural disasters such as Hurricanes Katrina and Rita of... UHF SONAR technology during times of extreme weather, such as hurricanes, could be required for...

  1. Experimental Reservoirs of Human Pathogens: The Vibrio Cholerae Paradigm (7th Annual SFAF Meeting, 2012)

    ScienceCinema

    Colwell, Rita

    2018-05-14

    Rita Colwell on "Experimental Reservoirs of Human Pathogens: The Vibrio cholerae paradigm" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  2. State Transportation Statistics 2013

    DOT National Transportation Integrated Search

    2014-09-19

    The Bureau of Transportation Statistics (BTS), a part of the U.S. Department of Transportations (USDOT) Research and Innovative Technology Administration (RITA), presents State Transportation Statistics 2013, a statistical profile of transportatio...

  3. State Transportation Statistics 2012

    DOT National Transportation Integrated Search

    2013-08-15

    The Bureau of Transportation Statistics (BTS), a part of the U.S. Department of Transportation's (USDOT) Research and Innovative Technology Administration (RITA), presents State Transportation Statistics 2012, a statistical profile of transportation ...

  4. Celebrating Leadership in Public Health and Medicine Friends of the National Library of Medicine (FNLM) | NIH ...

    MedlinePlus

    ... Michael E. DeBakey Medical Librarian Award Rita B. Smith, MLIS, AHIP, Outreach and Education Coordinator, Mercer University Medical Library and LRC Ms. Smith was honored for her outstanding service to the ...

  5. Transportation statistics annual report 2005

    DOT National Transportation Integrated Search

    2005-11-01

    In this edition of the Transportation Statistics Annual Report, the Bureau : of Transportation Statistics (BTS) of the U.S. Department of Transportation, : Research and Innovative Technology Administration (RITA), : focuses on transportation indicato...

  6. Experimental Reservoirs of Human Pathogens: The Vibrio Cholerae Paradigm (7th Annual SFAF Meeting, 2012)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Colwell, Rita

    Rita Colwell on "Experimental Reservoirs of Human Pathogens: The Vibrio cholerae paradigm" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  7. 75 FR 81284 - Nationwide Use of High Frequency and Ultra High Frequency Active SONAR Technology; Draft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... such as: The attacks of September 11, 2001; natural disasters such as Hurricanes Katrina and Rita of... technology during times of extreme weather, such as hurricanes, could be required for onshore areas that...

  8. R&D control study : plan for future jet fuel distribution quality control and description of fuel properties catalog

    DOT National Transportation Integrated Search

    2014-05-09

    The Broad Agency Announcement Alternative Aviation Fuels was a solicitation released by the U.S. Department of Transportation Research and Innovative Technology Administration (RITA) / John A. Volpe National Transportation Systems Center with funding...

  9. State transportation statistics 2009

    DOT National Transportation Integrated Search

    2009-01-01

    The Bureau of Transportation Statistics (BTS), a part of DOTs Research and : Innovative Technology Administration (RITA), presents State Transportation : Statistics 2009, a statistical profile of transportation in the 50 states and the : District ...

  10. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Henderson, Bradley G; Suszcynsky, David M; Hamlin, Timothy E

    Los Alamos National Laboratory (LANL) owns and operates an array of Very-Low Frequency (VLF) sensors that measure the Radio-Frequency (RF) waveforms emitted by Cloud-to-Ground (CG) and InCloud (IC) lightning. This array, the Los Alamos Sferic Array (LASA), has approximately 15 sensors concentrated in the Great Plains and Florida, which detect electric field changes in a bandwidth from 200 Hz to 500 kHz (Smith et al., 2002). Recently, LANL has begun development of a new dual-band RF sensor array that includes the Very-High Frequency (VHF) band as well as the VLF. Whereas VLF lightning emissions can be used to deduce physicalmore » parameters such as lightning type and peak current, VHF emissions can be used to perform precise 3d mapping of individual radiation sources, which can number in the thousands for a typical CG flash. These new dual-band sensors will be used to monitor lightning activity in hurricanes in an effort to better predict intensification cycles. Although the new LANL dual-band array is not yet operational, we have begun initial work utilizing both VLF and VHF lightning data to monitor hurricane evolution. In this paper, we present the temporal evolution of Rita's landfall using VLF and VHF lightning data, and also WSR-88D radar. At landfall, Rita's northern eyewall experienced strong updrafts and significant lightning activity that appear to mark a transition between oceanic hurricane dynamics and continental thunderstorm dynamics. In section 2, we give a brief overview of Hurricane Rita, including its development as a hurricane and its lightning history. In the following section, we present WSR-88D data of Rita's landfall, including reflectivity images and temporal variation. In section 4, we present both VHF and VLF lightning data, overplotted on radar reflectivity images. Finally, we discuss our observations, including a comparison to previous studies and a brief conclusion.« less

  11. ARC-2003-ACD03-0112-050

    NASA Image and Video Library

    2003-09-05

    NRTC/RITA Precision Pathway Terminal Guidance: UH-60 RASCAL (#012) (National Rotocraft Technology Center/Rotorcraft Industry Technology Association) runway independent aircraft; Sikorsky Helicopter pilot Kevin Bredenbeck preparing for flight in RASCAL with Dave Arterburn

  12. ARC-2003-ACD03-0112-046

    NASA Image and Video Library

    2003-09-05

    NRTC/RITA Precision Pathway Terminal Guidance: UH-60 RASCAL (#012) (National Rotocraft Technology Center/Rotorcraft Industry Technology Association) runway independent aircraft - Sikorsky Helicopter pilot Kevin Bredenbeck preparing for flight in RASCAL with Dave Arterburn

  13. ARC-2003-ACD03-0112-044

    NASA Image and Video Library

    2003-09-05

    NRTC/RITA Precision Pathway Terminal Guidance: UH-60 RASCAL (#012) (National Rotocraft Technology Center/Rotorcraft Industry Technology Association) runway independent aircraft - Sikorsky Helicopter pilot Kevin Bredenbeck preparing for flight in RASCAL with Dave Arterburn

  14. ARC-2003-ACD03-0112-047

    NASA Image and Video Library

    2003-09-05

    NRTC/RITA Precision Pathway Terminal Guidance: UH-60 RASCAL (#012) (National Rotocraft Technology Center/Rotorcraft Industry Technology Association) runway independent aircraft - Sikorsky Helicopter pilot Kevin Bredenbeck with Dave Arterburn and Ernie Morales of Ames

  15. ARC-2003-ACD03-0112-048

    NASA Image and Video Library

    2003-09-05

    NRTC/RITA Precision Pathway Terminal Guidance: UH-60 RASCAL (#012) (National Rotocraft Technology Center/Rotorcraft Industry Technology Association) runway independent aircraft - Sikorsky Helicopter pilot Kevin Bredenbeck with Dave Arterburn and Ernie Morales of Ames

  16. Transportation research : opportunities for improving the oversight of DOT's research programs and user satisfaction with transportation statistics : report to Congressional committees

    DOT National Transportation Integrated Search

    2006-08-01

    The Department of Transportations (DOT) research, development, and technology (RD&T) budget totaled $1.1 billion in fiscal year 2005. DOTs Research and Innovative Technology Administration (RITA)which includes the Bureau of Transportation St...

  17. GPS adjacent-band compatibility assessment plan.

    DOT National Transportation Integrated Search

    2012-12-01

    The Federal Aviation Administration (FAA) and the Research and Innovative Technology : Administration (RITA), both operating Administrations of the DOT, developed this Plan to : provide the framework for definition of the processes and assumptions th...

  18. United States, 2007 : 2007 Economic Census : transportation : 2007 commodity flow survey

    DOT National Transportation Integrated Search

    2010-04-01

    The 2007 Commodity Flow Survey (CFS) is undertaken : through a partnership between the U.S. Census Bureau, U.S. : Department of Commerce and the Research and Innovative : Technology Administration (RITA), Bureau of Transportation : Statistics (BTS), ...

  19. CRS&SI Technology Application Program.

    DOT National Transportation Integrated Search

    2012-07-01

    This project report presents details of research carried out by the George Mason University : Consortium under a research contract from the U.S. Department of Transportations Research : and Innovative Technology Administration (RITA), in support o...

  20. Driver behavior analysis at highway-rail grade crossings using field operational test data - light vehicles

    DOT National Transportation Integrated Search

    2013-05-31

    The U. S. Department of Transportations (U.S. DOT) Research and Innovative Technology Administrations (RITA) John A. Volpe National Transportation Systems Center (Volpe Center), under the direction of the U.S. DOT Federal Railroad Administratio...

  1. State Transportation Statistics 2011

    DOT National Transportation Integrated Search

    2012-08-08

    The Bureau of Transportation Statistics (BTS), a part of DOTs Research and Innovative Technology Administration (RITA), presents State Transportation Statistics 2011, a statistical profile of transportation in the 50 states and the District of Col...

  2. State Transportation Statistics 2010

    DOT National Transportation Integrated Search

    2011-09-14

    The Bureau of Transportation Statistics (BTS), a part of DOTs Research and Innovative Technology Administration (RITA), presents State Transportation Statistics 2010, a statistical profile of transportation in the 50 states and the District of Col...

  3. Evaluation of Education and Outreach Methods and Strategies - A Case Study of a Web-Based Rail Safety Education Initiative

    DOT National Transportation Integrated Search

    2014-04-01

    The U. S. Department of Transportations (U.S. DOT) Research and Innovative Technology Administrations (RITA) John A. Volpe National Transportation Systems Center (Volpe Center), under the direction of the U.S. DOT Federal Railroad Administratio...

  4. State transportation statistics 2005

    DOT National Transportation Integrated Search

    2005-12-01

    The Bureau of Transportation Statistics (BTS), a part of DOTs Research and Innovative : Technology Administration (RITA), presents State Transportation Statistics 2005, a : statistical profi le of transportation in the 50 states and the District o...

  5. State transportation statistics 2007

    DOT National Transportation Integrated Search

    2007-01-01

    The Bureau of Transportation Statistics (BTS), a part of DOTs Research and Innovative : Technology Administration (RITA), presents State Transportation Statistics 2007, a : statistical profi le of transportation in the 50 states and the District o...

  6. State transportation statistics 2006

    DOT National Transportation Integrated Search

    2006-12-01

    The Bureau of Transportation Statistics (BTS), a part of DOTs Research and Innovative : Technology Administration (RITA), presents State Transportation Statistics 2006, a : statistical profi le of transportation in the 50 states and the District o...

  7. Effect of dynamic envelope pavement markings on vehicle driver behavior at a highway-rail grade crossing

    DOT National Transportation Integrated Search

    2014-04-04

    The U. S. Department of Transportations (U.S. DOT) Research and Innovative Technology Administrations (RITA) John A. Volpe National Transportation Systems Center (Volpe Center), under the direction of the U.S. DOT Federal Railroad Administratio...

  8. Driver behavior analysis at highway-rail grade crossings using field operational test data - heavy trucks

    DOT National Transportation Integrated Search

    2012-12-31

    The United States Department of Transportations (U.S. DOT) Research and Innovative Technology Administrations (RITA) John A. Volpe National Transportation Systems Center (Volpe Center), under the direction of the U.S. DOT Federal Railroad Admin...

  9. Improving emergency evacuation preparedness : policy and organizational implications for transportation agencies.

    DOT National Transportation Integrated Search

    2013-03-01

    When Hurricanes Katrina and Rita ravaged the United States Gulf Coast in 2005, : the storms revealed woeful inadequacies in our nations emergency preparedness : and response capacities, including notably how we plan for and execute larg...

  10. Environmental chemical data for perishable sediments and soils collected in New Orleans, Louisiana, and along the Louisiana Delta following Hurricanes Katrina and Rita, 2005

    USGS Publications Warehouse

    Witt, Emitt C.; Shi, Honglan; Karstensen, Krista A.; Wang, Jianmin; Adams, Craig D.

    2008-01-01

    In October 2005, nearly one month after Hurricanes Katrina and Rita, a team of scientists from the U.S. Geological Survey and the Missouri University of Science and Technology deployed to southern Louisiana to collect perishable environmental data resulting from the impacts of these storms. Perishable samples collected for this investigation are subject to destruction or ruin by removal, mixing, or natural decay; therefore, collection is time-critical following the depositional event. A total of 238 samples of sediment, soil, and vegetation were collected to characterize chemical quality. For this analysis, 157 of the 238 samples were used to characterize trace element, iron, total organic carbon, pesticide, and polychlorinated biphenyl concentrations of deposited sediment and associated shallow soils. In decreasing order, the largest variability in trace element concentration was detected for lead, vanadium, chromium, copper, arsenic, cadmium, and mercury. Lead was determined to be the trace element of most concern because of the large concentrations present in the samples ranging from 4.50 to 551 milligrams per kilogram (mg/kg). Sequential extraction analysis of lead indicate that 39.1 percent of the total lead concentration in post-hurricane sediment is associated with the iron-manganese oxide fraction. This fraction is considered extremely mobile under reducing environmental conditions, thereby making lead a potential health hazard. The presence of lead in post-hurricane sediments likely is from redistribution of pre-hurricane contaminated soils and sediments from Lake Pontchartrain and the flood control canals of New Orleans. Arsenic concentrations ranged from 0.84 to 49.1 mg/kg. Although Arsenic concentrations generally were small and consistent with other research results, all samples exceeded the U.S. Environmental Protection Agency’s Human Health Medium-Specific Screening Level of 0.39 mg/kg. Mercury concentrations ranged from 0.02 to 1.30 mg

  11. Energy markets : refinery outages can have varying gasoline price impacts, but gaps in federal data limit understanding of impacts.

    DOT National Transportation Integrated Search

    2009-07-01

    In 2008, GAO reported that, with : the exception of the period : following Hurricanes Katrina and : Rita, refinery outages in the United : States did not show discernible : trends in reduced production : capacity, frequency, and location : from 2002 ...

  12. Freight in America : a new national picture

    DOT National Transportation Integrated Search

    2006-01-01

    According to new estimates by the Bureau of Transportation Statistics (BTS) of the U.S. Department of Transportations Research and Innovative Technology Administration (RITA) and the Federal Highway Administration (FHWA), over 19 billion tons of f...

  13. 75 FR 42818 - Agency Information Collection; Activity Under OMB Review; Collection of Safety Culture Data for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... DEPARTMENT OF TRANSPORTATION Research and Innovative Technology Administration Agency Information...: Research & Innovative Technology Administration (RITA), Bureau of Transportation Statistics (BTS), DOT... the evaluation of a demonstration/ research program on voluntary reporting of close calls and near...

  14. Impact of Hurricane Katrina on roadways in the New Orleans Area : technical assistance report.

    DOT National Transportation Integrated Search

    2007-03-01

    On August 29, 2005, Hurricane Katrina devastated New Orleans and southeastern Louisiana, leaving hundreds of thousands either displaced or homeless. Nearly four weeks later, Hurricane Rita made landfall in the southwestern portion of the state, furth...

  15. Points of pride 2007 : Volpe National Transportation Systems Center.

    DOT National Transportation Integrated Search

    2007-01-01

    Points of Pride highlights the annual accomplishments of the Volpe Center and illustrates its vital role as a unique federal resource within the U.S. Department of Transportations (U.S. DOT) Research and Innovative Technology Administration (RITA)...

  16. 77 FR 2345 - Advisory Council on Transportation Statistics; Request for Nominations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... Transportation Statistics Advisory Council on Transportation Statistics; Request for Nominations AGENCY: Research and Innovative Technology Administration (RITA), Bureau of Transportation Statistics (BTS), DOT. ACTION: Request for Nominations to the Advisory Council on Transportation Statistics (ACTS). SUMMARY: The...

  17. MoDOT research peer exchange.

    DOT National Transportation Integrated Search

    2011-04-01

    The Missouri Department of Transportation hosted a peer exchange on April 11-12, 2011 in Jefferson City, Missouri. Participants included representatives from four state DOTs, The National Academies, USDOT-RITA, FHWA, and both public and private resea...

  18. Landscape-Scale Analysis of Wetland Sediment Deposition from Four Tropical Cyclone Events

    PubMed Central

    Tweel, Andrew W.; Turner, R. Eugene

    2012-01-01

    Hurricanes Katrina, Rita, Gustav, and Ike deposited large quantities of sediment on coastal wetlands after making landfall in the northern Gulf of Mexico. We sampled sediments deposited on the wetland surface throughout the entire Louisiana and Texas depositional surfaces of Hurricanes Katrina, Rita, Gustav, and the Louisiana portion of Hurricane Ike. We used spatial interpolation to model the total amount and spatial distribution of inorganic sediment deposition from each storm. The sediment deposition on coastal wetlands was an estimated 68, 48, and 21 million metric tons from Hurricanes Katrina, Rita, and Gustav, respectively. The spatial distribution decreased in a similar manner with distance from the coast for all hurricanes, but the relationship with distance from the storm track was more variable between events. The southeast-facing Breton Sound estuary had significant storm-derived sediment deposition west of the storm track, whereas sediment deposition along the south-facing coastline occurred primarily east of the storm track. Sediment organic content, bulk density, and grain size also decreased significantly with distance from the coast, but were also more variable with respect to distance from the track. On average, eighty percent of the mineral deposition occurred within 20 km from the coast, and 58% was within 50 km of the track. These results highlight an important link between tropical cyclone events and coastal wetland sedimentation, and are useful in identifying a more complete sediment budget for coastal wetland soils. PMID:23185635

  19. An Analysis of Temperature and Pressure Data from Connected Vehicles in the Developmental Testbed Environment

    DOT National Transportation Integrated Search

    2009-06-09

    With funding and support from the USDOT RITA and direction from the FHWA Road Weather Management Program, NCAR is developing a Vehicle Data Translator (VDT) that incorporates vehicle-based measurements of the road and surrounding atmosphere with othe...

  20. Addressing Concerns About the Major Investment Study Requirements

    DOT National Transportation Integrated Search

    2011-12-01

    With funding and support from the USDOT RITA and direction from the FHWA Road Weather Management Program, NCAR is developing a Vehicle Data Translator (VDT) software system that incorporates vehicle-based measurements of the road and surrounding atmo...

  1. The vehicle data translator V3.0 system description.

    DOT National Transportation Integrated Search

    2011-05-30

    With funding and support from the USDOT RITA and direction from the FHWA Road Weather Management Program, NCAR is developing a Vehicle Data Translator (VDT) software system that incorporates vehicle-based measurements of the road and surrounding atmo...

  2. The vision for use of connected vehicle data in practical road weather applications.

    DOT National Transportation Integrated Search

    2011-12-01

    With funding and support from the USDOT RITA and direction from the FHWA Road Weather Management Program, NCAR is developing a Vehicle Data Translator (VDT) software system that incorporates vehicle-based measurements of the road and surrounding atmo...

  3. Results from the integrated mobile observations study.

    DOT National Transportation Integrated Search

    2013-05-01

    With funding and support from the USDOT RITA and direction from the FHWA Road Weather Management Program, NCAR is developing a Vehicle Data Translator (VDT) software system that incorporates vehicle-based measurements of the road and surrounding atmo...

  4. Workplace/Women's Place: An Anthology.

    ERIC Educational Resources Information Center

    Dunn, Dana

    The following papers are included: "Foreword" (Paula England); "Introduction to the Study of Women and Work" (Dana Dunn); "Gender Culture and Socialization" (Rita Mae Kelly); "Parental Influence and Women's Careers" (Sue Joan Mendelson Freeman); "Shortchanging Girls: Gender Socialization in…

  5. 78 FR 28943 - Agency Information Collection; Activity Under OMB Review; Passenger Origin-Destination Survey Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ... techniques or other forms of information technology. DATES: Written comments should be submitted by July 15... DEPARTMENT OF TRANSPORTATION Research & Innovative Technology Administration [Docket ID Number RITA 2008-0002] Agency Information Collection; Activity Under OMB Review; Passenger Origin-Destination...

  6. The influence of Hurricanes Katrina and Rita on the inflammatory cytokine response and protein expression in A549 cells exposed to PM2.5 collected in the Baton Rouge-Port Allen industrial corridor of Southeastern Louisiana in 2005.

    PubMed

    Bourgeois, Brian; Owens, John Wesley

    2014-03-01

    Hurricanes Katrina and Rita hit the coast of Louisiana in 2005 and killed more than 2000 people. The two storms resulted in a significant spike in particulate matter (PM2.5) levels across the state of Louisiana. This report focuses on PM2.5 samples collected in 2005 from two monitoring sites in the neighboring cities of Baton Rouge and Port Allen, Louisiana. Inductively coupled plasma (ICP) revealed the presence of PM2.5-adsorbed representative and Fenton-active transition metals. Gas chromatography/mass spectrometry (GC-MS) analyses revealed the presence of 23 PAH compounds. Endotoxins were also detected. Metals and endotoxins were extracted with water. PAH were extracted with dichloromethane. In order to assess cytotoxicity, aqueous PM2.5 extracts were introduced to A549 Human Epithelial Lung Carcinoma Cells. Results indicated decreased cell viability in a dose-dependent manner, with an LC50 of 235 µg/ml and 250 µg/ml, respectively, for the two sites featured here. Endotoxins alone were not cytotoxic. The concentration of reactive oxygen species (ROS) and released LDH activity increased following exposure of A549 cells to aqueous PM2.5 extracts. Fluorescence microscopy revealed apoptotic and necrotic cell death mechanisms. ELISA revealed increased secretion of primary pro-inflammatory cytokines, IL-6, IL-8, and TNF-α. Global PCR gene expression revealed up-regulation of proteins associated with the cytokine storm; e.g. interleukins, chemokines, and TNF-α. Global antibody microarray was consistent with an inflammatory response, with up-regulation of cytokines involved in the down-field activation of the caspase cascade and kinase pathways. The up-regulation of metal-redox sensitive transcription factors, NF-κβ and AP-1, is consistent with a cell death mechanism initiated by Fenton-active transition metal redox catalysis.

  7. Long-term cardiovascular mortality after procedure-related or spontaneous myocardial infarction in patients with non-ST-segment elevation acute coronary syndrome: a collaborative analysis of individual patient data from the FRISC II, ICTUS, and RITA-3 trials (FIR).

    PubMed

    Damman, Peter; Wallentin, Lars; Fox, Keith A A; Windhausen, Fons; Hirsch, Alexander; Clayton, Tim; Pocock, Stuart J; Lagerqvist, Bo; Tijssen, Jan G P; de Winter, Robbert J

    2012-01-31

    The present study was designed to investigate the long-term prognostic impact of procedure-related and spontaneous myocardial infarction (MI) on cardiovascular mortality in patients with non-ST-elevation acute coronary syndrome. Five-year follow-up after procedure-related or spontaneous MI was investigated in the individual patient pooled data set of the FRISC-II (Fast Revascularization During Instability in Coronary Artery Disease), ICTUS (Invasive Versus Conservative Treatment in Unstable Coronary Syndromes), and RITA-3 (Randomized Intervention Trial of Unstable Angina 3) non-ST-elevation acute coronary syndrome trials. The principal outcome was cardiovascular death up to 5 years of follow-up. Cumulative event rates were estimated by the Kaplan-Meier method; hazard ratios were calculated with time-dependent Cox proportional hazards models. Adjustments were made for the variables associated with long-term outcomes. Among the 5467 patients, 212 experienced a procedure-related MI within 6 months after enrollment. A spontaneous MI occurred in 236 patients within 6 months. The cumulative cardiovascular death rate was 5.2% in patients who had a procedure-related MI, comparable to that for patients without a procedure-related MI (hazard ratio 0.66; 95% confidence interval, 0.36-1.20, P=0.17). In patients who had a spontaneous MI within 6 months, the cumulative cardiovascular death rate was 22.2%, higher than for patients without a spontaneous MI (hazard ratio 4.52; 95% confidence interval, 3.37-6.06, P<0.001). These hazard ratios did not change materially after risk adjustments. Five-year follow-up of patients with non-ST-elevation acute coronary syndrome from the 3 trials showed no association between a procedure-related MI and long-term cardiovascular mortality. In contrast, there was a substantial increase in long-term mortality after a spontaneous MI.

  8. Clarus quality checking algorithm documentation report.

    DOT National Transportation Integrated Search

    2010-12-21

    With funding and support from the USDOT RITA IntelliDrive(SM) initiative and direction from the FHWA Road Weather Management Program, NCAR enhanced QCh algorithms that are a part of the current Clarus System. Moreover, NCAR developed new QCh algorith...

  9. Highway evacuations in selected metropolitan areas : assessment of impediments.

    DOT National Transportation Integrated Search

    2010-04-01

    Almost 5 years after hurricanes Katrina and Rita battered Louisiana and Texas, respectively, public officials remain focused on the Nations ability to safely evacuate large numbers of people. As a part of the Fiscal Year 2010 U.S. Department of Tr...

  10. Emergency reconstruction of critical transportation infrastructure.

    DOT National Transportation Integrated Search

    2008-12-01

    The recent damage caused by hurricanes, Katrina, Rita, and Wilma have demonstrated the potential for enormous property damage and loss of life as well as disruption of government and other institutions in Alabama. Similar damage could be the result o...

  11. 76 FR 4992 - Agency Information Collection: Activity Under OMB Review: Report of Financial and Operating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... Operating Statistics for Large Certificated Air Carriers AGENCY: Research & Innovative Technology Administration (RITA), Bureau of Transportation Statistics (BTS), DOT. ACTION: Notice. SUMMARY: In compliance with the Paperwork Reduction Act of 1995, Public Law 104-13, the Bureau of Transportation Statistics...

  12. Real-time data for hurricane evacuation in Texas

    DOT National Transportation Integrated Search

    2008-02-01

    In September 2005, the threat of Hurricane Rita to the Houston-Galveston region resulted in the evacuation of more than one million persons from the Texas coastal and urban areas. This concentration of evacuees overloaded all routes leaving the Houst...

  13. Streamlining Transportation Corridors Planning Processes and Validating the Application of Commercial Remote Sensing and Spatial Information (CRS-SI) Technologies for Environmental Impact Assessments

    DOT National Transportation Integrated Search

    2008-02-05

    The new US DOT RITA program has selected MSU for addressing corridor planning and environmental assessment in new and innovative ways that can be compared to traditional approaches. Our primary focus is on the application and validation of new and in...

  14. 75 FR 41921 - Agency Information Collection; Activity Under OMB Review; Report of Passengers Denied Confirmed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... Confirmed Space AGENCY: Research & Innovative Technology Administration (RITA), Bureau of Transportation... Title: Report of passengers Denied Confirmed Space. Form No.: Form 251. Type Of Review: Re-instatement..., travelers and travel agents can select carriers with lower incidences of bumping passengers. This...

  15. Crustal strain accumulation on Southern Basin and Range Province faults modulated by distant plate boundary earthquakes? Evidence from geodesy, seismic imaging, and paleoseismology

    NASA Astrophysics Data System (ADS)

    Bennett, R. A.; Shirzaei, M.; Broermann, J.; Spinler, J. C.; Holland, A. A.; Pearthree, P.

    2014-12-01

    GPS in Arizona reveals a change in the pattern of crustal strain accumulation in 2010 and based on viscoelastic modeling appears to be associated with the distant M7.2 El Mayor-Cucapah (EMC) earthquake in Baja California, Mexico. GPS data collected between 1999 and 2009 near the Santa Rita normal fault in SE Arizona reveal a narrow zone of crustal deformation coincident with the fault trace, delineated by W-NW facing Pleistocene fault scarps of heights 1 to 7 m. The apparent deformation zone is also seen in a preliminary InSAR interferogram. Total motion across the zone inferred using an elastic block model constrained by the pre-2010 GPS measurements is ~1 mm/yr in a sense consistent with normal fault motion. However, continuous GPS measurements throughout Arizona reveal pronounced changes in crustal velocity following the EMC earthquake, such that the relative motion across the Santa Rita fault post-2010 is negligible. Paleoseismic evidence indicates that mapped Santa Rita fault scarps were formed by two or more large magnitude (M6.7 to M7.6) surface rupturing normal-faulting earthquakes 60 to 100 kyrs ago. Seismic refraction and reflection data constrained by deep (~800 m) well log data provide evidence of progressive, possibly intermittent, displacement on the fault through time. The rate of strain accumulation observed geodetically prior to 2010, if constant over the past 60 to 100 kyrs, would imply an untenable minimum slip rate deficit of 60 to 100 m since the most recent earthquake. One explanation for the available geodetic, seismic, and paleoseismic evidence is that strain accumulation is modulated by viscoelastic relaxation associated with frequent large magnitude earthquakes in the Salton Trough region, episodically inhibiting the accumulation of elastic strain required to generate large earthquakes on the Santa Rita and possibly other faults in the Southern Basin and Range. An important question is thus for how long the postseismic velocity changes

  16. A film about teenage pregnancy.

    PubMed

    Smith, S

    1989-01-01

    "Consequences," a film on teenage pregnancy, was made in Africa with support from the Pathfinder Fund, an American foundation, International Planned Parenthood Federation, and the Ford foundation. Its messages are the repercussions of pregnancy, the use of contraception (especially condoms, as they help to stop the transmission of the acquired immunodeficiency syndrome), and the need for teenagers to communicate with their parents. The abortion issue was handled by making the points that it is illegal and dangerous. Harriet Masembe, a Ugandan folk lorist helped develop the story line. A Zimbabwean, Olley Mauma, wrote the dialogue and directed the film. Segun Oyekunle, a Nigerian script writer, commented on the draft script. The story is that Rita, a 16- year-old African is bright and has a steady boy friend. She will soon graduate from high school and go on to university. Then she discovers her pregnancy. Her relationship with Richard, her boy friend, breaks down. Her school performance deteriorates. Both Rita and Rick get expelled from school. Rita is sent to her mother's village to have a child. She finds this is very hard, and includes a lot of responsibility. She comes home a year later, but finds it difficult to relate to her friends. The boy friend suddenly returns home, too. At the end of the 54-minute film, we are left wondering what will happen to Rita and Richard. The film was pretested with 250 teenagers in Kenya, Nigeria, and Zimbabwe, and others in London and the US. The script was translated into French, Shona, and Sindebele. A Swahili version is being made. The film is being placed with nongovernmental organizations and their agencies. There has been much publicity and the film has won 2 international awards. Parts of the film were shown on German television. Distribution began in May, 1988. Since then some 300 copies and 600 videos have been sent out. There is a copy in each of the 45 agencies affiliated with International Planned Parenthood

  17. Adult Education Research Conference. Proceedings (26th, Tempe, Arizona, March 22-24, 1985).

    ERIC Educational Resources Information Center

    Arizona State Univ., Tempe.

    These proceedings contain the texts of the following 44 papers: "Adult Development in Midlife, Childless Women" (Rita Keneipp); "Analysis of the Relationship between Cognitive Style (Field Dependence-Field Independence) and Level of Learning" (Eugene Tootle); "Reconceptualizing Adult Education Participation" (Peter Cookson); "Adulthood:…

  18. 77 FR 18305 - Agency Information Collection; Activity Under OMB Review; Report of Passengers Denied Confirmed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of... Title: Report of Passengers Denied Confirmed Space. Form No.: BTS Form 251. Type of Review... operational difficulties. Because the rate of denied boarding is released quarterly, travelers and travel...

  19. 77 FR 33808 - Agency Information Collection; Activity Under OMB Review: Report of Passengers Denied Confirmed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of.... SUPPLEMENTARY INFORMATION: OMB Approval No. 2138-0018 Title: Report of Passengers Denied Confirmed Space. Form... quarterly, travelers and travel agents can select carriers with lower incidences of bumping passengers. This...

  20. 77 FR 16116 - Agency Information Collection; Activity Under OMB Review; Report of Extension of Credit to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ... Transportation Statistics [Docket: RITA 2008-0002 BTS Paperwork Reduction Notice] Agency Information Collection... of Transportation Statistics (BTS), DOT. ACTION: Notice. SUMMARY: In compliance with the Paperwork Reduction Act of 1995, Public Law 104-13, the Bureau of Transportation Statistics invites the general public...

  1. 76 FR 39155 - Agency Information Collection; Activity Under OMB Review; Report of Financial and Operating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ... RITA 2008-0002] Agency Information Collection; Activity Under OMB Review; Report of Financial and... Desk Officer. SUPPLEMENTARY INFORMATION: OMB Approval No. 2138-0013 Title: Report of Financial and... obligated to provide the International Civil Aviation Organization with financial and statistical data on...

  2. Dr. Rita Hocog Inos Fellowship Act

    THOMAS, 112th Congress

    Rep. Sablan, Gregorio Kilili Camacho [D-MP-At Large

    2011-01-26

    House - 02/04/2011 Referred to the Subcommittee on Fisheries, Wildlife, Oceans, and Insular Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  3. 76 FR 54531 - Pipeline Safety: Potential for Damage to Pipeline Facilities Caused by the Passage of Hurricanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... production and processing is prone to disruption by hurricanes. In 2005, Hurricanes Katrina and Rita caused... Hurricanes AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice... the passage of Hurricanes. ADDRESSES: This document can be viewed on the Office of Pipeline Safety...

  4. 78 FR 27479 - Notice of Request for Approval To Continue To Collect New Information: Confidential Close Call...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... project. This data collection effort is in support of a five-year research study aiming at improving rail... ongoing research study is conducted by the Office of Human Factors in the Federal Railroad Administration... DEPARTMENT OF TRANSPORTATION Research and Innovative Technology Administration [Docket Number RITA...

  5. 77 FR 12641 - Privacy Act of 1974; System of Records Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... research study in order to contact that individual, or to retrieve property at the end of the study... of 1974; System of Records Notice AGENCY: Research and Innovative Technology Administration's (RITA... titled Vehicle and Driver Research, Test, and Evaluation Records. This system [[Page 12642

  6. Literacy Instruction: Practices, Problems, Promises. Proceedings of the Annual Conference and Course on Literacy (37th, Pittsburgh, Pennsylvania, June 1990).

    ERIC Educational Resources Information Center

    King, Caryn M., Comp.; Bean, Rita M., Comp.

    This conference proceedings document contains 18 papers focusing on ideas and strategies for effective literacy instruction. Following opening remarks by Rita M. Bean, are four keynote addresses: "Toward Uncommon Sense Literacy Learning; Integrating Reading and Writing" (John Mayher); "Literacy Learning in At-Risk First…

  7. Health Issues in Aging. The Health Education Monograph Series, Volume 18, Number 2.

    ERIC Educational Resources Information Center

    Ogletree, Roberta, Ed.; Doyle, Kathy, Ed.

    This monograph presents a collection of papers related to health issues and aging: "Introduction" (Paul Simon); "Memory, Aging, and Cognition" (Rita E. Arras); "Internet Resources for the Elderly and Their Caregivers" (Kathleen Doyle); "Unintentional Injuries in the Homes of the Elderly: A Look at Current…

  8. 75 FR 22831 - Federal Property Suitable as Facilities To Assist the Homeless

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... Engineering & Construction Management, MA-50, 1000 Independence Ave., SW., Washington, DC 20585: (202) 586-5422; Interior: Mr. Michael Wright, Acquisition & Property Management, Department of the Interior, 1849... Theresa Rita, Division of Property Management, Program Support Center, HHS, room 5B-17, 5600 Fishers Lane...

  9. 78 FR 55338 - ITS Joint Program Office; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... DEPARTMENT OF TRANSPORTATION Research and Innovative Technology Administration ITS Joint Program Office; Notice of Meeting AGENCY: Research and Innovative Technology Administration (RITA), U.S. Department of Transportation. ACTION: Notice. This notice announces the cancellation of the Connected Vehicle Planning and Policy Stakeholder Meeting. Th...

  10. 75 FR 21717 - Agency Information Collection; Activity Under OMB Review; Report of Passengers Denied Confirmed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of.... Title: Report of Passengers Denied Confirmed Space. Form No: BTS Form 251. Type of Review: Extension of..., travelers and travel agents can select carriers with lower incidences of bumping passengers. This...

  11. 78 FR 60997 - Agency Information Collection: Activity Under OMB Review: Report of Passengers Denied Confirmed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of... Confirmed Space. Form No.: BTS Form 251. Type of Review: Re-instatement of an expired collection... boarding is released quarterly, travelers and travel agents can select carriers with lower incidences of...

  12. 77 FR 66502 - Agency Information Collection Activity; Notice of Request for Approval to Collect New Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-05

    ... Statistics (BTS), Research and Innovative Technology Administration (RITA), U.S. Department of Transportation... Transportation Statistics to request the Office of Management and Budget (OMB) to approve the following... Operations (DGMO) and the President/Business Agent of the Amalgamated Transit Union (ATU) Local 689. It is...

  13. Campus as Context.

    ERIC Educational Resources Information Center

    Current Issues in Catholic Higher Education, 1982

    1982-01-01

    Issues in Catholic higher education are considered in several articles. In "Catholic Students and Catholic Higher Education," Rita A. Scherrei summarizes research findings regarding the characteristics of incoming Catholic college students and how they compare with Jews and Traditional Protestants. Among the results are that Catholic…

  14. Promoting Probabilistic Programming System (PPS) Development in Probabilistic Programming for Advancing Machine Learning (PPAML)

    DTIC Science & Technology

    2018-03-01

    MARCH 2018 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED STINFO COPY AIR FORCE RESEARCH LABORATORY INFORMATION...SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) Air Force Research Laboratory/RITA DARPA 525 Brooks Road 675 North Randolph Street Rome...1 3.0 METHODS , ASSUMPTIONS, AND PROCEDURES

  15. 78 FR 43272 - Agency Information Collection; Activity Under OMB Review; Report of Passengers Denied Confirmed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of...: Report of Passengers Denied Confirmed Space. Form No.: BTS Form 251. Type of Review: Reinstatement of an.... Because the rate of denied boarding is released quarterly, travelers and travel agents can select carriers...

  16. Power and Involvement in Three Fictional Schools from the Silver Screen.

    ERIC Educational Resources Information Center

    Schwartz, Audrey James

    Using Amitai Etzioni's (1961) sociological model as a basis for analysis, the paper examines the relationship between central student characters and their chief reference group or significant other(s) in the schools as portrayed in three films: "If" (1969), "Child's Play" (1972), and "Educating Rita" (1983). Two…

  17. 77 FR 64375 - Advisory Council on Transportation Statistics; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ... Transportation Statistics; Notice of Meeting AGENCY: Research and Innovative Technology Administration (RITA), U... Advisory Council on Transportation Statistics (ACTS). The meeting will be held on Wednesday, December 12... Transportation Statistics subject to the Federal Advisory Committee Act (5 U.S.C., App. 2) to advise the Bureau...

  18. 78 FR 66104 - Advisory Council on Transportation Statistics; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... Transportation Statistics; Notice of Meeting AGENCY: Research and Innovative Technology Administration (RITA), U... of the Advisory Council on Transportation Statistics (ACTS). The meeting will be held on Tuesday... Council on Transportation Statistics subject to the Federal Advisory Committee Act (5 U.S.C., App. 2) to...

  19. 78 FR 11950 - Advisory Council on Transportation Statistics; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... Transportation Statistics; Meeting AGENCY: Research and Innovative Technology Administration (RITA), DOT. ACTION...) (Pub. L. 72-363; 5 U.S.C. app. 2), a meeting of the Advisory Council on Transportation Statistics (ACTS... Transportation to establish an Advisory Council on Transportation Statistics subject to the Federal Advisory...

  20. Aerial rapid assessment of hurricane damages to northern Gulf coastal habitats: Chapter 5A in Science and the storms-the USGS response to the hurricanes of 2005

    USGS Publications Warehouse

    Michot, Thomas C.; Wells, Christopher J.; Chadwick, Paul C.

    2007-01-01

    Hurricane Katrina made landfall in southeast Louisiana on August 29, 2005, and Hurricane Rita made landfall in southwest Louisiana on September 24, 2005. Scientists from the U.S. Geological Survey (USGS) flew aerial surveys to assess damages to natural resources and to lands owned and managed by the U.S. Department of the Interior and other agencies. Flights were made on eight dates from August 27 through October 4, including one pre-Katrina, three post-Katrina, and four post-Rita surveys. The geographic area surveyed extended from Galveston, Tex., to Gulf Shores, Ala., and from the Gulf of Mexico shoreline inland 5-75 mi (8-121 km). Impacts to barrier island habitats were severe, especially at the Chandeleur Islands, which were reduced in land area by roughly 50 percent. Marsh impacts varied but were greatest in St. Bernard and Cameron Parishes, where much emergent vegetation was scoured or killed. Forested wetlands were impacted heavily, especially in the Pearl River basin and on the cheniers of southwest Louisiana.

  1. 75 FR 70083 - Emergency Forest Restoration Program and Emergency Conservation Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... Iniki in 1993 and Hurricanes Katrina and Rita in 2005 where the extent and magnitude of damage made... rehabilitate farmland damaged by wind erosion, floods, hurricanes, or other natural disasters, and for carrying... the 2008 Farm Bill and the current ECP definition, which includes wildfires, hurricanes or excessive...

  2. Mesquite removal and mulching treatment impacts on herbage production and selected soil chemical properties

    Treesearch

    Stacy Pease; Peter F. Ffolliott; Leonard F. DeBano; Gerald J. Gottfried

    2003-01-01

    Determining the effects of mesquite (Prosopis velutina) overstory removal, posttreatment control of sprouting, and mulching treatments on herbage production (standing biomass) and selected soil chemical properties on the Santa Rita Experimental Range were the objectives of this study. Mesquite control consisted of complete overstory removals with and without the...

  3. Contribution of soil lead in children: A study from New Orleans, LA

    USDA-ARS?s Scientific Manuscript database

    During the last four years, a significant number of environmental studies have been conducted in New Orleans, LA and surrounding Gulf Coast areas due in part to the occurrence of hurricanes Katrina and Rita. Data collected from studies in the New Orleans area indicate that inorganic contaminants in...

  4. Fundraising Advice for College and University Presidents: An Insider's Guide

    ERIC Educational Resources Information Center

    Bornstein, Rita

    2011-01-01

    In these financially challenging times, chief executive officers of today's colleges and universities are expected to serve as their institutions' lead fundraisers. Still, many presidents remain uncomfortable in this essential role. With wisdom and insight, Rita Bornstein offers advice on how to identify, cultivate, and successfully solicit gifts…

  5. The Invitation of Life and Deciding How to Respond

    ERIC Educational Resources Information Center

    Parham, William D.

    2008-01-01

    Local, national, and global events that dominate today's media (e.g., war in Iraq, genocide in Darfur, historical lack of confidence in national political leadership, Katrina/Rita aftermath, etc.) represent open and ever-present personal invitations to "wake up" to the complex challenges that increasingly define communities across…

  6. Health Care Ethics: Dilemmas, Issues and Conflicts. Midwest Alliance in Nursing Annual Fall Workshop (6th, Indianapolis, Indiana, September 5-6, 1985).

    ERIC Educational Resources Information Center

    Prock, Valencia N., Ed.; And Others

    A variety of ethical issues confronting the nursing profession are examined in these proceedings. The following papers are presented: (1) "Ethics: Care & Conflict," by Leah Curtin; (2) "The Interface of Politics and Ethics in Nursing," by Mila Aroskar; (3) "Pluralistic Ethical Decision-Making," by Rita Payton; (4)…

  7. 77 FR 10616 - Advisory Council on Transportation Statistics; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... Transportation Statistics; Notice of Meeting AGENCY: Research and Innovative Technology Administration (RITA... on Transportation Statistics (ACTS). The meeting will be held on Tuesday, March 6, from 9 a.m. to 4... Advisory Council on Transportation Statistics subject to the Federal Advisory Committee Act (5 U.S.C. app...

  8. Teaching Foreign Languages.

    ERIC Educational Resources Information Center

    Holmes, Madelyn, Ed.

    1997-01-01

    Articles on second language education include: "Foreign Languages in Schools" (Madelyn Holmes), an overview of the benefits of language instruction in elementary and secondary education; "Japanese across the Miles" (Elizabeth Reiken), describing a high school distance learning program in Japanese; "Teaching Spanish as a Community Service" (Rita A.…

  9. Mesquite removal and mulching impacts on herbage production on a semidesert grass-shrub rangeland

    Treesearch

    Stacy Pease; Peter F. Ffolliott; Gerald J. Gottfried; Leonard F. DeBano

    2006-01-01

    The objectives of our study were to determining the effects of velvet mesquite (Prosopis velutina) removal, control of the resulting basal sprouts, and mulching treatments on herbage production (standing biomass) and selected soil chemicals (nutrients) shown to affect herbage production on the Santa Rita Experimental Range. Mesquite control...

  10. Land loss due to recent hurricanes in coastal Louisiana, U.S.A.

    USGS Publications Warehouse

    Palaseanu-Lovejoy, Monica; Kranenburg, Christine J.; Barras, John A.; Brock, John C.

    2013-01-01

    The aim of this study is to improve estimates of wetland land loss in two study regions of coastal Louisiana, U.S.A., due to the extreme storms that impacted the region between 2004 and 2009. The estimates are based on change-detection-mapping analysis that incorporates pre and postlandfall (Hurricanes Katrina, Rita, Gustav, and Ike) fractional-water classifications using a combination of high-resolution (<5 m) QuickBird, IKONOS, and GeoEye-1, and medium-resolution (30 m) Landsat Thematic Mapper satellite imagery. This process was applied in two study areas: the Hackberry area located in the southwestern part of chenier plain that was impacted by Hurricanes Rita (September 24, 2005) and Ike (September 13, 2008), and the Delacroix area located in the eastern delta plain that was impacted by Hurricanes Katrina (August 29, 2005) and Gustav (September 1, 2008). In both areas, effects of the hurricanes include enlargement of existing bodies of open water and erosion of fringing marsh areas. Surge-removed marsh was easily identified in stable marshes but was difficult to identify in degraded or flooded marshes. Persistent land loss in the Hackberry area due to Hurricane Rita was approximately 5.8% and increased by an additional 7.9% due to Hurricane Ike, although this additional area may yet recover. About 80% of the Hackberry study area remained unchanged since 2003. In the Delacroix area, persistent land loss due to Hurricane Katrina measured approximately 4.9% of the study area, while Hurricane Gustav caused minimal impact of 0.6% land loss by November 2009. Continued recovery in this area may further erase Hurricane Gustav's impact in the absence of new storm events.

  11. 7 CFR 1430.600 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... losses and dairy spoilage losses in eligible counties as a result of Hurricanes Katrina, Ophelia, Rita, and Wilma or conditions related to those hurricanes. (b) To be eligible for this program, a producer... a 2005 hurricane or related condition thereof, or in a contiguous county to a county that is...

  12. 7 CFR 1430.600 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... losses and dairy spoilage losses in eligible counties as a result of Hurricanes Katrina, Ophelia, Rita, and Wilma or conditions related to those hurricanes. (b) To be eligible for this program, a producer... a 2005 hurricane or related condition thereof, or in a contiguous county to a county that is...

  13. 7 CFR 1430.600 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... losses and dairy spoilage losses in eligible counties as a result of Hurricanes Katrina, Ophelia, Rita, and Wilma or conditions related to those hurricanes. (b) To be eligible for this program, a producer... a 2005 hurricane or related condition thereof, or in a contiguous county to a county that is...

  14. 7 CFR 1430.600 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... losses and dairy spoilage losses in eligible counties as a result of Hurricanes Katrina, Ophelia, Rita, and Wilma or conditions related to those hurricanes. (b) To be eligible for this program, a producer... a 2005 hurricane or related condition thereof, or in a contiguous county to a county that is...

  15. 7 CFR 1430.600 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... losses and dairy spoilage losses in eligible counties as a result of Hurricanes Katrina, Ophelia, Rita, and Wilma or conditions related to those hurricanes. (b) To be eligible for this program, a producer... a 2005 hurricane or related condition thereof, or in a contiguous county to a county that is...

  16. Reflecting on "Project Katrina" and Developmentally Appropriate Practices: A Graduate Student's Perspective

    ERIC Educational Resources Information Center

    Schellhaas, Andree; Burts, Diane C.; Aghayan, Carol

    2007-01-01

    This article describes the independent study project of a student who was a graduate assistant in a child development laboratory preschool when Hurricanes Katrina and Rita struck the Gulf Coast area. Through her experiences with "Project Katrina" she deepens her understanding of developmentally appropriate practices as she learns firsthand about…

  17. Scholars Who Teach: The Art of College Teaching.

    ERIC Educational Resources Information Center

    Cahn, Steven M., Ed.

    In essays on a variety of disciplines, seven college teachers discuss the art of inspiring enthusiasm in college students. The topics are: history (Russell H. Bostert); English (Edward B. Partridge); mathematics (Robert H. Gurland); science (Arnold B. Arons); social science (Rita W. Cooley); foreign language and literature (John G. Weiger); and…

  18. Desired General Education Competencies: A Corporate Perspective.

    ERIC Educational Resources Information Center

    Meyer, Rita; And Others

    A corporate perspective on the general education competencies expected of middle management and technical personnel is provided and responded to in these three papers. First, Rita Meyer presents results from a study conducted by West Virginia Northern Community College to obtain the views of corporate managers on the general education…

  19. Katrina's Children: Evidence on the Structure of Peer Effects from Hurricane Evacuees. NBER Working Paper No. 15291

    ERIC Educational Resources Information Center

    Imberman, Scott; Kugler, Adriana D.; Sacerdote, Bruce

    2009-01-01

    In 2005, hurricanes Katrina and Rita forced many children to relocate across the Southeast. While schools quickly enrolled evacuees, receiving families worried about the impact of evacuees on non-evacuee students. Data from Houston and Louisiana show that, on average, the influx of evacuees moderately reduced elementary math test scores in…

  20. 77 FR 26824 - Agency Information Collection; Activity Under OMB Review; Submission of Audit Reports-Part 248

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... RITA 2008-0002] Agency Information Collection; Activity Under OMB Review; Submission of Audit Reports.... SUPPLEMENTARY INFORMATION: OMB Approval No. 2138-0004. Title: Submission of Audit Reports--Part 248. Form No... having an annual audit must file a statement that no such audit has been performed. In lieu of the audit...

  1. 78 FR 65751 - Integrated Corridor Management Deployment Planning Grants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... Cronin, Team Leader, Research, Research and Innovative Technology Administration (RITA) ITS-Joint Program...:00 p.m. e.t. Registering with Grants.gov is a one-time process; however, processing delays may occur and it can take up to several weeks for first-time registrants to receive confirmation and a user...

  2. Rabies in the Americas

    Science.gov Websites

    Rabies in the Americas Search this site Welcome Previous Meetings Steering Committee Contact Sitemap Welcome The Rabies in the Americas (RITA) meeting is an annual event that has been held since 1990 managers of rabies programs, wildlife biologists, laboratory personnel and other people interested in

  3. Workshop Summaries: Excite Students with Tech

    ERIC Educational Resources Information Center

    Gonzalez, Augusta; Sonstrom, Stefanie; Silvey, Patricia; Boscarino, Maryanne; Shea, Ida; Trusz, Jean; Perugini, Dorie; Krzemien, Marta; Caplette, Pamela; Lindsey, Barbara; Lindstrom, Sarah

    2011-01-01

    Glastonbury Public Schools hosted the NNELL Northeast Regional Workshop on September 24, 2011 in which the theme was "Engaging Digital Natives". Rita A. Oleksak, Director of Foreign Languages/ELL and NNELL vice-president delivered the keynote speech motivating the teachers to engage foreign language learners within the classroom and across their…

  4. Introducing the Lifetime Exercise and Physical Activity Service-Learning (LE PAS) Program

    ERIC Educational Resources Information Center

    Carson, Russell L.

    2008-01-01

    In August and September 2005, two violent hurricanes--Katrina and Rita--hit Louisiana. Hundreds of thousands of residents were relocated to temporary living communities, where most of the economically poor remain today. This state's largest trailer community, "Renaissance Village," was erected almost overnight in a cow pasture in Baker,…

  5. Call for Papers. Correctional Education Association 1986 Annual Conference (Cincinnati, Ohio, July 6-9, 1986).

    ERIC Educational Resources Information Center

    Littlefield, John F., Ed.

    The 13 papers in this volume are: "Behind Bars with CBE--Look What's Happening to Inmate Training" (Beverly A. Stitt, Rita Noel); "Communication Skills: Relevance, Respect, Responsibility and the Process of Change" (Meredith Whaley); "The Educational Needs of Inmates in the Kingston Prison for Women" (Richard Volpe, Colleen Kearney); "The Effects…

  6. 78 FR 26113 - Advisory Council on Transportation Statistics; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... Transportation Statistics; Notice of Meeting AGENCY: Research and Innovative Technology Administration (RITA), U... Advisory Council on Transportation Statistics (ACTS). The meeting will be held on Monday, June 10 from 8:30... Transportation Statistics subject to the Federal Advisory Committee Act (5 U.S.C., App. 2) to advise the Bureau...

  7. Sheltering Children from the Whole Truth: A Critical Analysis of an Informational Picture Book.

    ERIC Educational Resources Information Center

    Lamme, Linda; Fu, Danling

    2001-01-01

    Uses Orbis Pictus Award Committee criteria (accuracy, organization, design, and style) to examine an informational book, "Rice Is Life," by Rita Golden Gelman. Subjects the book to a deeper critical analysis. Suggests that it is important to help students become critical thinkers about everything they read, including informational books.…

  8. 7 CFR 1430.604 - Eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Hurricane Katrina and Hurricane Rita the base month is July 2005 and the corresponding claim period are the... hurricane-related dairy disaster benefits under this part only if they have suffered dairy production or dairy spoilage losses in 2005 as a result of a hurricane disaster or related condition, in a hurricane...

  9. 7 CFR 1430.604 - Eligibility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Hurricane Katrina and Hurricane Rita the base month is July 2005 and the corresponding claim period are the... hurricane-related dairy disaster benefits under this part only if they have suffered dairy production or dairy spoilage losses in 2005 as a result of a hurricane disaster or related condition, in a hurricane...

  10. 7 CFR 1430.604 - Eligibility.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Hurricane Katrina and Hurricane Rita the base month is July 2005 and the corresponding claim period are the... hurricane-related dairy disaster benefits under this part only if they have suffered dairy production or dairy spoilage losses in 2005 as a result of a hurricane disaster or related condition, in a hurricane...

  11. 7 CFR 1430.604 - Eligibility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Hurricane Katrina and Hurricane Rita the base month is July 2005 and the corresponding claim period are the... hurricane-related dairy disaster benefits under this part only if they have suffered dairy production or dairy spoilage losses in 2005 as a result of a hurricane disaster or related condition, in a hurricane...

  12. 7 CFR 1430.604 - Eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Hurricane Katrina and Hurricane Rita the base month is July 2005 and the corresponding claim period are the... hurricane-related dairy disaster benefits under this part only if they have suffered dairy production or dairy spoilage losses in 2005 as a result of a hurricane disaster or related condition, in a hurricane...

  13. Academic Performance, School Desertion and Emotional Paradigm in University Students

    ERIC Educational Resources Information Center

    Sosa, Emma Rosa Cruz; Barrientos, Laura Gática; Castro, Patricia Eugenia García; García, Jesús Hernández

    2010-01-01

    The present work aims to describe academic performance, school desertion and the emotional paradigm of the university students of the accounting school of the Benemérita Universidad Autónoma de Puebla (FCPBUAP). We have found that low academic performance is related to students' economic deficiency, which affects their concentration on their…

  14. In the Eye of the Library: Poets at the Library of Congress.

    ERIC Educational Resources Information Center

    D'Ooge, Craig

    1998-01-01

    Chronicles the evolution of the position of consultant in poetry (in 1989, officially titled Poet Laureate Consultant in Poetry) at the Library of Congress from the 1930s to the present. Poets highlighted include Howard Nemerov, Alan Tate, Robert Penn Warren, Robert Hayden, Joseph Brodsky, Rita Dove, and Stanley Kunitz. A sidebar discusses…

  15. Gulf Coast Hurricanes: Lessons Learned for Protecting and Educating Children. Briefing for Congressional Staff. GAO-06-680R

    ERIC Educational Resources Information Center

    Government Accountability Office, 2006

    2006-01-01

    In August and September 2005, Hurricanes Katrina and Rita caused devastating damage to states along the Gulf Coast. In the aftermath of the storms, many questions were raised about the status of the thousands of children living in the affected areas. The US Government Accountability Office (GAO) prepared this preliminary information under the…

  16. When Disaster Strikes, Move Your School Online

    ERIC Educational Resources Information Center

    LaPrairie, Kimberly N.; Hinson, Janice M.

    2007-01-01

    Hurricanes Katrina and Rita displaced thousands of K-12 students and demonstrated that when K-12 schools close unexpectedly and indefinitely, educational chaos results. Events such as deadly flu outbreaks or bioterrorist attacks will have the same impact on education. These possibilities demonstrate the need for state and local officials to begin…

  17. Crisis Data Management: A Forum Guide to Collecting and Managing Data about Displaced Students. NFES 2010-804

    ERIC Educational Resources Information Center

    National Forum on Education Statistics, 2010

    2010-01-01

    In the aftermath of hurricanes Katrina and Rita, the immediate demand for data about displaced students overwhelmed many school districts that had gained or lost students because of the disasters. The scale of these crises and their effects on school operations and management were in many ways unprecedented. This guide reflects "lessons…

  18. Democrats Seek Education Department "Recovery Czar"

    ERIC Educational Resources Information Center

    Davis, Michelle R.

    2006-01-01

    As congressional Democrats declared last week that federal efforts to help Gulf Coast schools with hurricane recovery aren't working, school officials from the region hit by Hurricanes Katrina and Rita last year urged lawmakers to provide more regulatory flexibility and more money. On April 26, 2006, House Democrats released a report criticizing…

  19. Politician of the Year 2008: Lifting Louisiana

    ERIC Educational Resources Information Center

    Berry, John N., III

    2008-01-01

    This article features Mitch Landrieu and his contributions to the upliftment of Louisiana through libraries. After the onslaught of hurricanes Katrina and Rita, Landrieu said they realized how important libraries are. Now in his second term as lieutenant governor of Louisiana, Landrieu oversees the Office of the State Library along with the…

  20. Weathering the Storms: Acknowledging Challenges to Learning in Times of Stress

    ERIC Educational Resources Information Center

    Hubschman, Betty; Lutz, Marilyn; King, Christine; Wang, Jia; Kopp, David

    2006-01-01

    Students and faculty have had numerous disruptions this academic year with Hurricanes Katrina, Rita, and Wilma developing into major stressors. During this innovative session, we will examine some of the challenges and strategies used by faculty to work with students to maintain empathy and academic rigor in times of stress and disruption, and…

  1. 41 CFR 302-3.101 - As a transferred employee what relocation allowances must my agency pay or reimburse me for...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 302-15 of this chapter). 6. Transportation of a mobile home or boat used as a primary residence in lieu of the transportation of household goods (part 302-10 of this chapter) 6. Home marketing... chapter). 5. Relocation income tax allowance (RITA) (part 302-17 of this chapter) 1 5. Home marketing...

  2. Educators Reach out to Katrina Victims

    ERIC Educational Resources Information Center

    Hardy, Lawrence

    2006-01-01

    The emotional trauma of recent events may never go away. A million people were uprooted by Hurricane Katrina, including an estimated 372,000 children of school age. Three weeks later, Hurricane Rita slammed into the Texas-Louisiana coastline, forcing thousands more to evacuate. Acute symptoms of trauma range from confusion, nightmares, and…

  3. Gender.

    ERIC Educational Resources Information Center

    Grauer, Kit

    1996-01-01

    This publication focuses on the theme "Gender." Articles include: (1) "Sex! Violence! Death! Art Education for Boys" (Riita Vira; Finland); (2) "Pedagogy for a Gender Sensitive Art Practice" (Rita Irwin; Canada); (3) "Women's Conscientiousness of Gender in Art and Art Education in Brazil" (Ana Mae Barbosa; Brazil); (4) "Gender Issues in United…

  4. Native American Languages Act. Hearing before the Committee on Indian Affairs, United States Senate. One Hundred Eighth Congress, First Session on S. 575 To Amend the Native American Languages Act To Provide for the Support of Native American Language Survival Schools (May 15, 2003).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Indian Affairs.

    This document includes statements given at this hearing by the following: William Y. Brown; John Cheek, Jennifer Chock; Rita Coosewon; David Dinwoodie; William Demmert, Jr.; Joycelyn DesRosier; Mary Hermes; Carla Herrera; Leanne Hinton; Holo Ho'opai; Hon. Daniel K. Inouye; Lawrence D. Kaplan; Keiki Kawaiaea; Rosalyn, LaPier; Lisa LaRonge; Vina…

  5. We're Born to Learn: Using the Brain's Natural Learning Process to Create Today's Curriculum. Second Edition

    ERIC Educational Resources Information Center

    Smilkstein, Rita

    2011-01-01

    This updated edition of the bestselling book on the brain's natural learning process brings new research results and applications in a power-packed teacher tool kit. Rita Smilkstein shows teachers how to create and deliver curricula that help students become the motivated, successful, and natural learners they were born to be. Updated features…

  6. Vegetation management practices: Past and present

    Treesearch

    Peter F. Ffolliott; Gerald J. Gottfried; William H. Kruse

    2003-01-01

    Improving management practices have been at the core of most research conducted in the semidesert grass-shrub vegetation on the Santa Rita Experimental Range. Much of this research has been directed to sustaining forage resources through proper livestock grazing and controlling the invasion of competing woody plants, primarily mesquite. Both research orientations...

  7. Interview: Professor Helle Neergaard, President of the European Council for Small Business and Entrepreneurship, on the Nature of Creativity, Innovation and Entrepreneurship

    ERIC Educational Resources Information Center

    Industry and Higher Education, 2015

    2015-01-01

    On August 13, 2014, Rita G. Klapper conducted a Skype interview with Helle Neergaard. Neergaard is not only President of the European Council for Small Business and Entrepreneurship, but also Docent at the Hanken School of Economics, and Professor at iCARE, Department of Business Administration, School of Business and Social Sciences, University…

  8. 78 FR 14153 - Advisory Council on Transportation Statistics; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ... Transportation Statistics; Meeting AGENCY: Research and Innovative Technology Administration (RITA), DOT. ACTION... Statistics (ACTS). The meeting was scheduled for Monday, March 4, 2013 from 8:30 a.m. to 4:00 p.m. E.S.T. in...., Washington, DC. The Bureau of Transportation Statistics (BTS) will reschedule the meeting for a future date...

  9. All (Librarian) Hands on Deck: Librarians Lead the Way on the Long Journey to Recovery and Rebuilding

    ERIC Educational Resources Information Center

    Block, Marylaine; Kim, Ann

    2006-01-01

    This article describes how librarians stepped up to the plate to rescue materials and meet the needs of thousands of uprooted evacuees from Hurricanes Katrina and Rita, employing their unique skills and resources to put forth a humane and herculean effort. In Houston and Austin, Texas; Baton Rouge, Louisiana; Memphis; Fayetteville, Arkansas; and…

  10. Building Energy-Efficient Schools in New Orleans: Lessons Learned (Brochure)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This case study presents the lessons learned from incorporating energy efficiency in the rebuilding and renovating of New Orleans K-12 schools after Hurricanes Katrina and Rita. Hurricane Katrina was the largest natural disaster in the United States, striking the Gulf Coast on August 29, 2005, and flooding 80% of New Orleans; to make matters worse, the city was flooded again only three weeks later by the effects of Hurricane Rita. Many of the buildings, including schools, were heavily damaged. The devastation of schools in New Orleans from the hurricanes was exacerbated by many years of deferred school maintenance. This casemore » study presents the lessons learned from incorporating energy efficiency in the rebuilding and renovating of New Orleans K-12 schools after Hurricanes Katrina and Rita. The experiences of four new schools-Langston Hughes Elementary School, Andrew H. Wilson Elementary School (which was 50% new construction and 50% major renovation), L.B. Landry High School, and Lake Area High School-and one major renovation, Joseph A. Craig Elementary School-are described to help other school districts and design teams with their in-progress and future school building projects in hot-humid climates. Before Hurricane Katrina, New Orleans had 128 public schools. As part of the recovery planning, New Orleans Public Schools underwent an assessment and planning process to determine how many schools were needed and in what locations. Following a series of public town hall meetings and a district-wide comprehensive facility assessment, a Master Plan was developed, which outlined the renovation or construction of 85 schools throughout the city, which are expected to be completed by 2017. New Orleans Public Schools expects to build or renovate approximately eight schools each year over a 10-year period to achieve 21st century schools district-wide. Reconstruction costs are estimated at nearly $2 billion.« less

  11. 27 CFR 9.162 - Sta. Rita Hills.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... proceed north and slightly west 2.3 miles to an unnamed hilltop elevation 1174 feet, Section 15, T.6N., R. 32W. (3) Proceed west and slightly north 1.85 miles to an unnamed hilltop elevation 899 feet within....G.S. map. (4) Proceed north approximately 2 miles to an unnamed hilltop elevation 1063 feet within...

  12. 27 CFR 9.162 - Sta. Rita Hills.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... proceed north and slightly west 2.3 miles to an unnamed hilltop elevation 1174 feet, Section 15, T.6N., R. 32W. (3) Proceed west and slightly north 1.85 miles to an unnamed hilltop elevation 899 feet within....G.S. map. (4) Proceed north approximately 2 miles to an unnamed hilltop elevation 1063 feet within...

  13. 27 CFR 9.162 - Sta. Rita Hills.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... proceed north and slightly west 2.3 miles to an unnamed hilltop elevation 1174 feet, Section 15, T.6N., R. 32W. (3) Proceed west and slightly north 1.85 miles to an unnamed hilltop elevation 899 feet within....G.S. map. (4) Proceed north approximately 2 miles to an unnamed hilltop elevation 1063 feet within...

  14. 27 CFR 9.162 - Sta. Rita Hills.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... proceed north and slightly west 2.3 miles to an unnamed hilltop elevation 1174 feet, Section 15, T.6N., R. 32W. (3) Proceed west and slightly north 1.85 miles to an unnamed hilltop elevation 899 feet within....G.S. map. (4) Proceed north approximately 2 miles to an unnamed hilltop elevation 1063 feet within...

  15. 27 CFR 9.162 - Sta. Rita Hills.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... proceed north and slightly west 2.3 miles to an unnamed hilltop elevation 1174 feet, Section 15, T.6N., R. 32W. (3) Proceed west and slightly north 1.85 miles to an unnamed hilltop elevation 899 feet within....G.S. map. (4) Proceed north approximately 2 miles to an unnamed hilltop elevation 1063 feet within...

  16. Dr. Rita Hocog Inos Territorial Fellowship Act

    THOMAS, 113th Congress

    Rep. Sablan, Gregorio Kilili Camacho [D-MP-At Large

    2013-02-05

    House - 02/13/2013 Referred to the Subcommittee on Fisheries, Wildlife, Oceans, and Insular Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  17. The Impact of Child-Related Stressors on the Psychological Functioning of Lower-Income Mothers after Hurricane Katrina

    ERIC Educational Resources Information Center

    Lowe, Sarah R.; Chan, Christian S.; Rhodes, Jean E.

    2011-01-01

    In the present study, the authors examined the role of child-related stressors in the psychological adjustment of lower-income, primarily unmarried and African American, mothers (N = 386). All participants lived in areas affected by Hurricane Katrina, and about a third were also exposed to Hurricane Rita (30.3%, n = 117). Lacking knowledge of a…

  18. In Brief: Colwell resigns from NSF

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2004-02-01

    Rita Colwell, who has served as director of the U.S. National Science Foundation since August 1998, steps down from that position on 21 February. After fulfilling most of her 6-year term, Colwell will assume the chairmanship of Canon U.S. Life Sciences, Inc., an Arlington, Virginia-based subsidiary of Canon USA, Inc.

  19. Storms Spur Flood of Giving for Schools

    ERIC Educational Resources Information Center

    Robelen, Erik W.

    2005-01-01

    From elementary pupils cracking open their piggy banks to companies and foundations writing seven-figure checks, a flood of donations has reached schools and students affected by Katrina since the storm devastated parts of the Gulf Coast. Further help has gone to those affected by Hurricane Rita, which hit southwestern Louisiana and the coast of…

  20. 27 CFR 9.97 - Sonoita.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... feet) in the Canelo Hills. (ii) From there in a straight line eastward for approximately 10 miles, to...-northwestward for approximately 21 miles in a straight line to the summit of Granite Peak (7,413 feet) in the... Mount Wrightson (9,543 feet) in the Santa Rita Mountains. (2) Boundary Description—(i) From the starting...

  1. 27 CFR 9.97 - Sonoita.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... feet) in the Canelo Hills. (ii) From there in a straight line eastward for approximately 10 miles, to...-northwestward for approximately 21 miles in a straight line to the summit of Granite Peak (7,413 feet) in the... Mount Wrightson (9,543 feet) in the Santa Rita Mountains. (2) Boundary Description—(i) From the starting...

  2. 27 CFR 9.97 - Sonoita.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... feet) in the Canelo Hills. (ii) From there in a straight line eastward for approximately 10 miles, to...-northwestward for approximately 21 miles in a straight line to the summit of Granite Peak (7,413 feet) in the... Mount Wrightson (9,543 feet) in the Santa Rita Mountains. (2) Boundary Description—(i) From the starting...

  3. 27 CFR 9.97 - Sonoita.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... feet) in the Canelo Hills. (ii) From there in a straight line eastward for approximately 10 miles, to...-northwestward for approximately 21 miles in a straight line to the summit of Granite Peak (7,413 feet) in the... Mount Wrightson (9,543 feet) in the Santa Rita Mountains. (2) Boundary Description—(i) From the starting...

  4. 27 CFR 9.97 - Sonoita.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... feet) in the Canelo Hills. (ii) From there in a straight line eastward for approximately 10 miles, to...-northwestward for approximately 21 miles in a straight line to the summit of Granite Peak (7,413 feet) in the... Mount Wrightson (9,543 feet) in the Santa Rita Mountains. (2) Boundary Description—(i) From the starting...

  5. Spread of a nonnative grass across southern Arizona: Multiple data sources to monitor change

    Treesearch

    Erika Geiger; Theresa Mau-Crimmins; Heather Schussman

    2003-01-01

    In 1934, Eragrostis lehmanniana was introduced into southeastern Arizona to control erosion and provide forage for cattle. The earliest of these introductions took place on the Santa Rita Experimental Range (SRER) in 1937 and continued there until the early 1960s. Numerous researchers have observed a convincing association between an increased proportion of E....

  6. Citizenship: My Father's Way

    ERIC Educational Resources Information Center

    Carter, Paula

    2009-01-01

    In this article, the author shares her experience teaching at Rita Cannan Elementary, in Reno, Nevada, and describes how she and her colleagues teach lessons on citizenship education that are part of their social studies program. She describes an approach she used, which focused on student leadership rather than teacher intervention, that led to…

  7. Revisiting the Gulf Coast after Katrina

    ERIC Educational Resources Information Center

    Principal, 2009

    2009-01-01

    In August 2005, the world witnessed one of the most destructive natural disasters on America's mainland. Hurricane Katrina, followed a month later by Hurricane Rita, brought more than broken levees, flooded streets and homes, and destroyed businesses. It caused changes in the dynamics and the demographic and cultural makeup of the region. One of…

  8. Achieving Educational Excellence in Majuro, RMI. Promising Practices in the Pacific Region.

    ERIC Educational Resources Information Center

    Donahue, Tim

    The Rita Christian School on Majuro in the Republic of the Marshall Islands is a comprehensive preK-8 program that has successfully combined factors that contribute to an effective school program for the Pacific region. Factors contributing to the school's success are community involvement, strong leadership, a committed and well-trained staff,…

  9. New data sources and derived products for the SRER digital spatial database

    Treesearch

    Craig Wissler; Deborah Angell

    2003-01-01

    The Santa Rita Experimental Range (SRER) digital database was developed to automate and preserve ecological data and increase their accessibility. The digital data holdings include a spatial database that is used to integrate ecological data in a known reference system and to support spatial analyses. Recently, the Advanced Resource Technology (ART) facility has added...

  10. Co-operative Learning for Students with Difficulties in Learning: A Description of Models and Guidelines for Implementation

    ERIC Educational Resources Information Center

    Murphy, Ellen; Grey, Ian M.; Honan, Rita

    2005-01-01

    As part of a larger study regarding the inclusion of children with disabilities in mainstream classroom settings, Ellen Murphy, of the D Clin Psych programme at NUI Galway, with Ian Grey and Rita Honan, from Trinity College, Dublin, reviewed existing literature on co-operative learning in the classroom. In this article, they identify four models…

  11. "You Are a Flaw in the Pattern": Difference, Autonomy and Bullying in YA Fiction

    ERIC Educational Resources Information Center

    Lopez-Ropero, Lourdes

    2012-01-01

    Though portrayals of bullying in children's books stretch back to Victorian public school stories, this article sees a new subgenre about bullying in young adult novels emerging in the post-Columbine years. Selected works by Jerry Spinelli, Walter Dean Myers, Jaime Adoff, Carol Plum-Ucci and Rita Williams-Garcia are examined, although the article…

  12. Watered by Tempests: Hurricanes in the Cultural Fabric of the United Houma Nation

    ERIC Educational Resources Information Center

    D'Oney, J. Daniel

    2008-01-01

    Hurricanes Katrina and Rita affected hundreds of thousands in southern Louisiana. To say that they touched people of every stripe and color dramatically is a gross understatement. Aside from the loss of life and property damage, families were uprooted, traditions disrupted, and one of the largest migrations in American history forced on a state…

  13. Reading Improvement through Art Replicator Manual of Instruction, 3rd Edition

    ERIC Educational Resources Information Center

    Corwin, Sylvia K., Ed.

    2013-01-01

    Reading Improvement Through Art (RITA) program is an interdisciplinary approach to literacy that blends visual art with reading comprehension, evaluated in nine New York City urban high schools. 240 problem readers participating in the pilot program were pre- and post-tested in the Fall 1975 and Spring 1976 semesters. The testing showed the 9th…

  14. Authentic Collaborative Inquiry: Initiating and Sustaining Partner Research in the PDS Setting

    ERIC Educational Resources Information Center

    James, Jennifer Hauver; Kobe, Jessica; Shealey, Glennda; Foretich, Rita; Sabatini, Ellen

    2015-01-01

    This is the story of our collaborative work as educators and researchers. Because writing as a collective is challenging, we have elected Jenn to serve as narrator, but the story is ours collectively. We are Glennda and Rita, elementary school teachers, Ellen, principal, and Jess, graduate research assistant. The story told here is distilled from…

  15. 20 African-Americans Your Students Should Meet

    ERIC Educational Resources Information Center

    Bardeen, Tara

    2008-01-01

    There is more to Black History Month than honoring Martin Luther King Jr. Black History Month is a time to honor the significant contributions of African-Americans throughout history. This article presents 20 super-achievers new generation of African-Americans heroes students should meet: (1) Kimberly Oliver; (2) John Lewis; (3) Rita Dove; (4)…

  16. Land area change analysis following hurricane impacts in Delacroix, Louisiana, 2004--2009

    USGS Publications Warehouse

    Palaseanu-Lovejoy, Monica; Kranenburg, Christine J.; Brock, John C.

    2012-01-01

    The purpose of this project is to provide improved estimates of Louisiana wetland land loss due to hurricane impacts between 2004 and 2009 based upon a change detection mapping analysis that incorporates pre- and post-landfall (Hurricanes Katrina, Rita, Gustav, and Ike) fractional water classification of a combination of high resolution (QuickBird, IKONOS and Geoeye-1) and medium resolution (Landsat) satellite imagery. This second dataset focuses on Hurricanes Katrina and Gustav, which made landfall on August 29, 2005, and September 1, 2008, respectively. The study area is an approximately 1208-square-kilometer region surrounding Delacroix, Louisiana, in the eastern Delta Plain. Overall, 77 percent of the area remained unchanged between 2004 and 2009, and over 11 percent of the area was changed permanently by Hurricane Katrina (including both land gain and loss). Less than 3 percent was affected, either temporarily or permanently, by Hurricane Gustav. A related dataset (SIM 3141) focused on Hurricane Rita, which made landfall on the Louisiana/Texas border on September 24, 2005, as a Category 3 hurricane.

  17. Lime

    USGS Publications Warehouse

    Miller, M.

    2006-01-01

    In 2005, US lime production was 20 Mt with a value of $1.5 billion. Production was unchanged compared with 2004. Captive production was 1.4 Mt. US consumption was 20.2 Mt. Most of the US lime trade was with Canada and Mexico. Despite some disruptions due to hurricanes Katrina and Rita, normal sales activities remained healthy.

  18. Restructuring, Restoring and Rebuilding

    ERIC Educational Resources Information Center

    Hamilton, Kendra

    2006-01-01

    The 27 institutions damaged by hurricanes Katrina or Rita--there were 14 in Mississippi, 12 in Louisiana and one in Alabama--estimate their combined physical damages at $1.4 billion. But rather than providing aid, the Louisiana Legislature was forced to call for $77 million in cuts in November, leading to a wrenching gut-check on many campuses.…

  19. Telling Katrina Stories: Problems and Opportunities in Engaging Disaster

    ERIC Educational Resources Information Center

    Bowman, Michael S.; Bowman, Ruth Laurion

    2010-01-01

    As the fifth anniversary of life-changing events like Hurricanes Katrina and Rita approaches, the authors talk about the problems those who reside at the site of the disaster face in keeping those events alive in public memory and in making them an ongoing issue for deliberation in the public sphere. In short, then, the authors address the…

  20. Reading Queer Counter-Narratives in the High-School Literature Classroom: Possibilities and Challenges

    ERIC Educational Resources Information Center

    Helmer, Kirsten

    2016-01-01

    Drawing on an ethnographic case study of a 13-week Gay and Lesbian Literature course, this paper explores how a high-school teacher and her students engaged with queer-themed literature. Focused on episodes around the class' engagement with two of the novels read in the course--Rita Mae Brown's "Rubyfruit Jungle" and Michael Cunningham's…

  1. Early Literacy and Assessment for Learning (K-3) Series: Exploring Comprehension through Retelling: A Teacher's Story

    ERIC Educational Resources Information Center

    Pacific Resources for Education and Learning (PREL), 2005

    2005-01-01

    Rita is a Pacific island grade 2 teacher in a local village school. She has established a 90-minute daily literacy block in which she focuses on literacy-related activities. As she sits with her students during the literacy block, she realizes some of them are having difficulty comprehending text, and many are unable to retell the stories…

  2. Autistic Spectrum Disorders: A Challenge and a Model for Inclusion in Education

    ERIC Educational Resources Information Center

    Jordan, Rita

    2008-01-01

    Rita Jordan, Professor in Autism Studies at the School of Education, University of Birmingham, gave last year's Gulliford Lecture at the University of Birmingham on 4 October 2007. This article is based upon that lecture. In it, Professor Jordan discusses the role of education in the lives of people with autistic spectrum disorders. She traces the…

  3. "Achtung" Maybe: A Case Study of the Role of Personal Connection and Art in the Literary Engagement of Students with Attentional Difficulties

    ERIC Educational Resources Information Center

    Smagorinsky, Peter; Cameron, Tricia; O'Donnell-Allen, Cindy

    2007-01-01

    This study examines a collaborative reading of John Keats's poem, "When I Have Fears That I May Cease to Be," by two high school seniors with attentional difficulties in a mainstream British Literature class, with a focus on one of the students, Rita. The data consist of a retrospective verbal protocol during which the students recounted their…

  4. Schools Get Katrina Aid, Uncertainty: $645 Million May Not Cover Costs of Displaced Students

    ERIC Educational Resources Information Center

    Klein, Alyson

    2006-01-01

    As federal aid for students uprooted by Hurricanes Katrina and Rita begins making its way to cash-strapped school districts, many educators are worried that the money Congress allocated will fall well short of their costs. Since the hurricanes damaged hundreds of schools in the Gulf Coast region and initially dispersed nearly 375,000 students,…

  5. Alternative Fuels Data Center: CNG Fleets Aid in Superstorm Recovery

    Science.gov Websites

    AddThis.com... May 24, 2013 CNG Fleets Aid in Superstorm Recovery " They were working around the clock aftermath, helping with recovery efforts. "They were working around the clock," said Rita Ebert accelerating. As part of GLICCC's efforts to build on the momentum, the coalition is now working with the New

  6. School Nurse Resilience: Experiences after Multiple Natural Disasters

    ERIC Educational Resources Information Center

    Broussard, Lisa; Myers, Rachel

    2010-01-01

    This qualitative descriptive study explored the experiences of school nurses in coastal Louisiana, who were affected by Hurricanes Gustav and Ike in 2008 and who had also been in the path of destruction caused by Hurricanes Katrina and Rita in 2005. The purpose of the study was to describe the experiences of school nurses affected by repeated…

  7. Schooling the Forgotten Kids of Hurricane Katrina

    ERIC Educational Resources Information Center

    Cook, Glenn

    2006-01-01

    In this article, the author talks about students being taking in public schools in Houston and Dallas, as well as other states, after evacuating from New Orleans which was struck by Hurricane Katrina and Hurricane Rita. For students displaced by the storm, mobility is as constant as stability is elusive. Already traumatized and faced with the loss…

  8. Hydrology and soil erosion

    Treesearch

    Leonard J. Lane; Mary R. Kidwell

    2003-01-01

    We review research on surface water hydrology and soil erosion at the Santa Rita Experimental Range (SRER). Almost all of the research was associated with eight small experimental watersheds established from 1974 to 1975 and operated until the present. Analysis of climatic features of the SRER supports extending research findings from the SRER to broad areas of the...

  9. Vulnerable Medicine

    ERIC Educational Resources Information Center

    Bochner, Arthur P.

    2009-01-01

    In "Narrative Medicine: Honoring the Stories of Illness," Rita Charon paints an original and humane portrait of what it can mean to be a doctor, to live a life immersed in sickness and dedicated to wellness. Charon drops the veil, inviting readers to look at the secret, subjective, emotional face of medicine, a zone of self-censored feelings and…

  10. Historical Trauma: Holocaust Victims, American Indians Recovering from Abuses of the Past

    ERIC Educational Resources Information Center

    Deschenie, Tina

    2006-01-01

    Natural disasters and terrorism have raised national awareness of major human trauma. In fall 2005, Hurricanes Katrina and Rita forced hundreds of thousands of people to evacuate from their homes. Among American Indian people, these times bring to mind the trauma suffered by their ancestors: The Trail of Tears during the 1830s removed 18,000…

  11. Effects of neighbor species and distance on 2- and 4-year survival of Lehmann lovegrass and native grasses

    Treesearch

    Sharon H. Biedenbender; Mitchel P. McClaran; Bruce A. Roundy

    2003-01-01

    The relationship between Lehmann lovegrass, an invasive African grass, and native Southwestern grasses has not been fully determined. The first purpose of this study was to compare the survival of Lehmann lovegrass with two native grasses (plains lovegrass and Arizona cottontop) seeded on the Santa Rita Experimental Range in southeast Arizona in 1994. One year after...

  12. Multisensory integration, sensory substitution and visual rehabilitation.

    PubMed

    Proulx, Michael J; Ptito, Maurice; Amedi, Amir

    2014-04-01

    Sensory substitution has advanced remarkably over the past 35 years since first introduced to the scientific literature by Paul Bach-y-Rita. In this issue dedicated to his memory, we describe a collection of reviews that assess the current state of neuroscience research on sensory substitution, visual rehabilitation, and multisensory processes. Copyright © 2014. Published by Elsevier Ltd.

  13. Rocky Mountain Research Station: 2005 Research Accomplishments

    Treesearch

    Rick Fletcher

    2006-01-01

    During 2005, the USDA Forest Service celebrated its Centennial, recognizing 100 years of successfully caring for the land and serving people. The Rocky Mountain Research Station has been, and continues to be, an integral part of the Forest Service mission, dating back to the Agency's beginning, with the establishment of the Santa Rita Experimental Range near...

  14. Return of the Tarahumara frog to Arizona

    Treesearch

    James C. Rorabaugh; Stephen F. Hale; Michael J. Sredl; Craig Ivanyi

    2005-01-01

    The last wild Tarahumara frog (Rana tarahumarae) in Arizona was found dead in Big Casa Blanca Canyon, Santa Rita Mountains, in May 1983. However, the species is still well represented in the majority of its range in the northern Sierra Madre Occidental and adjacent Sky Islands of Sonora and Chihuahua. Plans to re-establish R. tarahumarae...

  15. Helping Libraries

    ERIC Educational Resources Information Center

    Rosenfeld, Esther

    2005-01-01

    For people who are living in North America, the destruction caused by Hurricanes Katrina and Rita has shown them both the humbling power of natural forces and the fragility of man-made structures. The devastation to the Gulf Coast of the United States has left destruction and damage to schools and colleges and the displacement of 372,000 K-12…

  16. African Art: An Essay for Teachers, Curriculum Handbook.

    ERIC Educational Resources Information Center

    Kelso, Ann B., Ed.

    In an introductory section by Michael D. Harris, this resource presents a discussion of aspects and problems in the WEstern study of African Art. This is followed by six lesson plans based on art works from the Fred and Rita Richman Collection of Sub-Saharan Art in the High Museum. The handbook follows Georgia's Quality Core Curriculum and the Ten…

  17. History of Forest Service Research in the Central and Southern Rocky Mountain Regions, 1908-1975

    Treesearch

    Raymond Price

    1976-01-01

    The first forest research area established by the Forest Service was in 1908­the Fort Valley Experimental Forest near Flagstaff, Arizona. In 1909, the Fremont Experiment Station near Colorado Springs was begun, as well as the Wagon Wheel Gap watershed experiment in the central Rockies. The Santa Rita Range Reserve, begun in 1903, was transferred to the Forest Service...

  18. Proceedings of the Rural Early Childhood Forum on Hurricane Recovery and Emergency Preparedness (Mobile, Alabama, December 5, 2005). Rural Early Childhood Report No. 4

    ERIC Educational Resources Information Center

    Shores, Elizabeth F., Ed.

    2006-01-01

    When Hurricanes Katrina and Rita struck the Gulf Coast of the United States in August and September 2005, it was arguably the worst calamity to strike the region in history. Less well known than the loss in life or property from these storms are the effects on early care and education. Those who work with or on behalf of young children found in…

  19. Talking with Children about Natural Disasters

    ERIC Educational Resources Information Center

    Brodkin, Adele M.

    2005-01-01

    The effects of Hurricane Katrina, Hurricane Rita, and other natural disasters will be felt by young children in the affected areas for a long time to come. This article offers tips on how to talk with children about natural disasters in order to clear up any confusion they might have, how to answer their questions with sensitivity, and how to…

  20. Hurricane Aid Is on the Way to Districts, Private Schools

    ERIC Educational Resources Information Center

    Robelen, Erik W.; Davis, Michelle R.

    2006-01-01

    The U.S. Department of Education in early January of 2006 sent out the first installment--more than $250 million--in education aid to states affected by Hurricanes Katrina and Rita, just days after President Bush signed the measure into law. The $1.6 billion relief package has drawn fire from some education groups because it provides aid not just…

  1. Steps to Developing the New Orleans Strategic Energy Plan (Presentation)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brown, E.

    2011-01-01

    This presentation was given by NREL's Elizabeth Doris (Brown) to the New Orleans City Council in January 2008. NREL was funded by DOE to provide technical assistance to New Orleans after Hurricanes Katrina and Rita. The presentation provides an overview of strategic energy planning, case studies, and suggested next steps for implementing energy efficiency and renewable energy into the city's rebuilding efforts.

  2. 2013 Annual Report for ONR Sponsored Research: A Multiscale Study of Tropical Cyclone Formation, Structure Change and Predictability in the Western North Pacific Region & TCS08 Experiment Support

    DTIC Science & Technology

    2013-09-30

    Eye and Eyewall of Hurricane Hugo (1989) and was published in Mon. Wea. Rev., 136, 1237-1259. ...Bell, Michael M., 2010: Air-Sea Enthalpy and Momentum Exchange at Major Hurricane Wind Speeds. Ph.D. Dissertation. U.S. Naval Postgraduate School...axisymmetric view of concentric eyewall evolution in Hurricane Rita (2005). J. Atmos. Sci., 69: 2414-2432, [refereed, published]. Bell, Michael M

  3. Local Area Network (LAN) Compatibility Issues

    DTIC Science & Technology

    1991-09-01

    September, 1991 Thesis Advisor: Dr. Norman Schneidewind Approved for public release; distribution is unlimited 92 303s246 Unclassified SECURITY ...CLASSIFICATION OF THIS PAGE REPORT DOCUMENTATION PAGE Ia. REPORT SECURITY CLASSIFICATION 1 b. RESTRICTIVE MARKINGS unclassified 2a. SECURITY CLASSIFICATION...Work UiNt ACCeLUOn Number 11. TITLE (Include Security Classification) LOCAL AREA NETWORK (LAN) COMPATIBILITY ISSUES 12. PERSONAL AUTHOR(S) Rita V

  4. Assessment of fire-damaged mesquite trees 8 years following an illegal burn

    Treesearch

    Gerald J. Gottfried; Peter F. Ffolliott; Pablo Garcia; Diego Valdez-Zamudio; Akram Al-Khouri

    2003-01-01

    Effects of an illegal burn on the Santa Rita Experimental Range on mesquite (Prosopis velutina) survival in the semidesert grass-shrub ecosystem was initially assessed in terms of firedamage classes 18 months after the fire and again 8 years after the burn. While many of the mesquite trees on the burned site were damaged by the fire, some of the trees appear to have...

  5. Options for Educating Students Attending Department of Defense Schools in the United States

    DTIC Science & Technology

    2016-01-01

    Middlemiss, Martha Brown, Stephen F. Hovanic, Joel Hansen, Frank O’Gara, Elaine Kanellis, Robert M. Brady, Claudia Shaw , Jessica Ray Huffman, Rita...could receive students. Chapter Three explains our methods and data sources for assessing options, including the business case analysis approach...account for these analyses. We also identify implementation issues and barriers for each option, based on work of previous studies with updates to

  6. The Road to Remarkable: Directed by Vision, Driven by Strength--2010 Five-Year Report of the Policy and Planning Board

    ERIC Educational Resources Information Center

    American Psychologist, 2011

    2011-01-01

    The 2010 Policy and Planning Board of the American Psychological Association (APA) was chaired by Elena J. Eisman, EdD. Other members of the board included Gwyneth M. Boodoo, PhD; G. Rita Dudley-Grant, PhD; Beverly Greene, PhD; Christopher W. Loftis, PhD; Michael J. Murphy, PhD; Paul D. Nelson, PhD; Kurt Salzinger, PhD; and Michael Wertheimer,…

  7. RItA: The Italian severe/uncontrolled asthma registry.

    PubMed

    Maio, S; Baldacci, S; Bresciani, M; Simoni, M; Latorre, M; Murgia, N; Spinozzi, F; Braschi, M; Antonicelli, L; Brunetto, B; Iacovacci, P; Roazzi, P; Pini, C; Pata, M; La Grasta, L; Paggiaro, P; Viegi, G

    2018-03-01

    The Italian severe/uncontrolled asthma (SUA) web-based registry encompasses demographic, clinical, functional, and inflammatory data; it aims to raise SUA awareness, identifying specific phenotypes and promoting optimal care. Four hundred and ninety three adult patients from 27 Italian centers (recruited in 2011-2014) were analyzed. Mean age was 53.8 years. SUA patients were more frequently female (60.6%), with allergic asthma (83.1%). About 30% showed late onset of asthma diagnosis/symptoms (>40 years); the mean age for asthma symptoms onset was 30.2 years and for asthma diagnosis 34.4 years. 97.1% used ICS (dose 2000 BDP), 93.6% LABA in association with ICS, 53.3% LTRAs, 64.1% anti-IgE, 10.7% theophylline, and 16.0% oral corticosteroids. Mean FEV 1 % pred of 75.1%, median values of 300/mm 3 of blood eosinophil count, 323 kU/L of serum total IgE, and 24 ppb of FENO were shown. Most common comorbidities were allergic rhinitis (62.4%), gastroesophageal reflux (42.1%), sinusitis (37.9%), nasal polyposis (30.2%), and allergic conjunctivitis (30.2%). 55.7% of SUA patients had exacerbations in the last 12 months, 9.7% emergency department visits, and 7.3% hospitalizations. Factors associated with exacerbation risk were obesity (OR, 95% CI 2.46, 1.11-5.41), psychic disorders (2.87, 0.89-9.30-borderline), nasal polyps (1.86, 0.88-3.89-borderline), partial/poor asthma treatment adherence (2.54, 0.97-6.67-borderline), and anti-IgE use in a protective way (0.26, 0.12-0.53). Comparisons to severe asthma multicenter studies and available registries showed data consistency across European and American populations. An international effort in the implementation of SUA patients' registries could help to better understand the clinical features and to manage severe asthma, representing a non-negligible socioeconomic burden for health services. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

  8. Development of a Method for Assessing the Organizational, Cultural, and Political Considerations Affecting the Insertion of Siloms into the MoD

    DTIC Science & Technology

    2002-03-01

    Patterson AFB, Ohio. Upon his graduation in 2002 he will be assigned to ILA. Permanent Address: Institutto de Logistica da Aeronautica - ILA, Av...Henrique Sbrissia, Capt Rita de Cassia, Capt Flavio Marcio de Souza and Capt Fabricio Saito. Special thanks to Janice Farr for providing help in...information related to maintenance, supply, and transportation within the COMGAP. The overall goal of the system is to provide information to support

  9. Predicting Coarse Sediment Transport from Patchy Beds in Ephemeral Channels

    DTIC Science & Technology

    2012-04-01

    ct u re s La b or at or y Brendan T. Yuill April 2012 Approved for public release; distribution is unlimited. ERDC/GSL TR-12-17 April...5  Figure 3. Photographic map of a section of the Lucky Hills channel bed without (A) and with ( B ) the...diagram of the Santa-Rita type flume looking upstream (A) and a close-up photograph of the slot-sampler looking downstream ( B

  10. A Taxonomy of Operational Risks

    DTIC Science & Technology

    2005-09-01

    the operational organization. Con - tractual constraints or requirements can impose risk if the mission delivers products or services under contract...Carnegie Mellon Software Engineering Institute A Taxonomy of Operational Risks CMU/SEI-2005-TN-036 Brian P. Gallagher Pamela J. Case DIST...Operational Risks CMU/SEI-2005-TN-036 Brian P. Gallagher Pamela J. Case Rita C. Creel Susan Kushner Ray C. Williams September2005 Acquisition Support Program

  11. Russian Strategic Communications and Implications for NATO

    DTIC Science & Technology

    2017-04-06

    officially opened its doors on 20 August 2015 in the Latvian capital of Riga. Today, the center conducts analysis and study of Russian information and...Walden: Military Studies Press. 2011. 23 Dr. Steve Tatham and LTC Rita Le Page. NATO Strategic Communication: More to be Done? Case Study . Riga...Fokin, Alexander. Internet Trolling as a Tool of Hybrid Warfare: The Case of Latvia. Case Study , Riga: NATO Strategic Communication Center of

  12. Continued Analysis on Multiscale Aspects of Tropical Cyclone Formation, Structure Change and Predictability in the Western North Pacific Region as Part of the TCS08 DRI

    DTIC Science & Technology

    2012-09-30

    Atmospheric Administration. The published paper was entitled “Structure of the Eye and Eyewall of Hurricane Hugo (1989) and was published in Mon. Wea. Rev., 136, 1237-1259. ...developments in tropical cyclone intensification theory A new paradigm of tropical cyclone intensification and hurricane boundary layer dynamics has been... Hurricane Rita (2005) show strong support for the second spin-up mechanism in the concentric eyewall lifecycle. Didlake and Houze (2011) found a

  13. Multipli-Entangled Photons from a Spontaneous Parametric Down-Conversion Source

    DTIC Science & Technology

    2011-01-01

    Alsing, Corey J. Peters (AFRL/RITA); Enrique J. Galvez ( Colgate University, Hamilton, NY) 5d. PROJECT NUMBER QIS0 5e. TASK NUMBER PR 5f...and Enrique J. Galvez Colgate University, Hamilton, NY (USA) 1. ABSTRACT In this work, we discuss a novel compact source that generates six...single pair of entangled photons per pass in conventional SPDC-based sources. We first describe the experimental testbed used for evaluation and

  14. Systemization of Secure Computation

    DTIC Science & Technology

    2015-11-01

    STINFO COPY AIR FORCE RESEARCH LABORATORY INFORMATION DIRECTORATE AFRL-RI-RS-TR-2015-241  UNITED STATES AIR FORCE  ROME, NY 13441 AIR FORCE...any patented invention that may relate to them. This report is the result of contracted fundamental research deemed exempt from public affairs...ES) Air Force Research Laboratory/RITA DARPA 525 Brooks Road 675 North Randolph Street Rome NY 13441-4505 Arlington, VA 22203

  15. The Clustering of Galaxies and Dark Matter at Intermediate Redshifts

    NASA Technical Reports Server (NTRS)

    Jain, Bhuvnesh; Szalay, Alexander

    2003-01-01

    Theoretical work in the study of weak lensing was begun while the Scientific PI (Jain) was at the Johns Hopkins University. A new postdoctoral fellow, Rita Kim, was hired to work for 0.5 years on the proposed research. She was unable to join JHU until March 2001 owing to delays in her PhD work. Meanwhile PI Jain moved to the University of Pennsylvania in January 2001. Owing to the above circumstances, the work for the proposed research was delayed and was expected to be carried out in the remainder of 2001. New measures of lensing based on the magnification effect were to be investigated by Drs. Jain and Kim. The simulations needed to test the analytical computations were already in place; hence the work was expected to proceed fairly rapidly. Owing to the close proximity of JHU and UPenn, the collaborative work was expected to proceed smoothly. It was requested therefore that the funds for the first grant year (2000-2001) be transferred to the second year. Part of the funding was spent at JHU on the salary for the Postdoctoral Fellow, Rita Kim, and the remainder at the University of Pennsylvania. The work from this grant is incomplete and will be continued under another grant.

  16. Photodynamic injury of isolated crayfish neuron and surrounding glial cells: the role of p53

    NASA Astrophysics Data System (ADS)

    Sharifulina, S. A.; Uzdensky, A. B.

    2015-03-01

    The pro-apoptotic transcription factor p53 is involved in cell responses to injurious impacts. Using its inhibitor pifithrin- α and activators tenovin-1, RITA and WR-1065, we studied its potential participation in inactivation and death of isolated crayfish mechanoreceptor neuron and satellite glial cells induced by photodynamic treatment, a strong inducer of oxidative stress. In dark, p53 activation by tenovin-1 or WR-1065 shortened activity of isolated neurons. Tenovin-1 and WR-1065 induced apoptosis of glial cells, whereas pifithrin-α was anti-apoptotic. Therefore, p53 mediated glial apoptosis and suppression of neuronal activity after axotomy. Tenovin-1 but not other p53 modulators induced necrosis of axotomized neurons and surrounding glia, possibly, through p53-independent pathway. Under photodynamic treatment, p53 activators tenovin-1 and RITA enhanced glial apoptosis indicating the pro-apoptotic activity of p53. Photoinduced necrosis of neurons and glia was suppressed by tenovin-1 and, paradoxically, by pifithrin-α. Modulation of photoinduced changes in the neuronal activity and necrosis of neurons and glia was possibly p53-independent. The different effects of p53 modulators on neuronal and glial responses to axotomy and photodynamic impact were apparently associated with different signaling pathways in neurons and glial cells.

  17. Land Area Changes in Coastal Louisiana After the 2005 Hurricanes: A Series of Three Maps

    USGS Publications Warehouse

    Barras, John A.

    2006-01-01

    This report includes three posters with analyses of net land area changes in coastal Louisiana after the 2005 hurricanes (Katrina and Rita). The first poster presents a basic analysis of net changes from 2004 to 2005; the second presents net changes within marsh communities from 2004 to 2005; and the third presents net changes from 2004 to 2005 within the historical perspective of change in coastal Louisiana from 1956 to 2004. The purpose of this analysis was to provide preliminary information on land area changes shortly after Hurricanes Katrina and Rita and to serve as a regional baseline for monitoring wetland recovery following the 2005 hurricane season. Estimation of permanent losses cannot be made until several growing seasons have passed and the transitory impacts of the hurricanes are minimized, but this preliminary analysis indicates an approximate 217-mi2 (562.03-km2) decrease in land/increase in water across coastal Louisiana. These posters are presented in high-resolution PDF format that is not Section 508 compliant. For ease in accessibility, viewing, and printing, each poster is accompanied by PDF files that contain the corresponding methodology, tables, and figures. Funding for this project was provided by the Louisiana Coastal Area (LCA) Science & Technology Office.

  18. Education and Training Issues Related to Major Disasters

    DTIC Science & Technology

    2005-11-04

    Mississippi that were affected by Hurricane Katrine would be permitted to reduce their academic year from 30 weeks of instructional time to 26 weeks... hurricanes . In addition, it is estimated that approximately 30 institutions of higher education (IHEs) in the affected areas have been severely damaged...of Hurricanes Katrina and Rita on employment probably resulted in the loss of between 293,000 and 480,000 jobs. Many of these individuals will not

  19. The CRRES Langmuir Probe and Fluxgate Magnetometer Instrument

    DTIC Science & Technology

    1989-05-09

    Gbntract tenager Branch Chief i r FOR THE COWhbDER RITA C. SAGALYN Division Director Qualified requestors may obtain additional copies from the... Computations 73 2.9 Sawtooth Generation 80 2.10 Bias Sweeps 84 2.11 Main Program Loader 96 2.12 Boom Deployment 98 2.13 General Utilities...separated by 100 meters. The other pair of conductors are cylindrical wire boom elements also in the spin plane that are separated by an effective

  20. JPRS Report, Latin America.

    DTIC Science & Technology

    1987-06-05

    tareas of land which, they claim, belongs to them in Montecristi. The farm workers traveled from Ruta de Rita locality, and gave notice that they...8217 Children Without Schools 44 MNR Ousting Mocked 45 BRAZIL Poll Shows 70 Percent Favor Shorter Term for Sarney (FOLHA DE SAO PAULO, 15 Mar 87) 46...8217CUT’ President on Talks With Government, Strike Plans (Jair Meneguelli Interview; FOLHA DE SAO PAULO, 6 Apr 87) 50 Parliamentary System