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1

Lacrimal sac tumors.  

PubMed

This is a clinicopathologic study of 115 lacrimal sac neoplasms in adults (mean 52 years). The most common presenting signs and symptoms were epiphora (53%), recurrent dacryocystitis (38%), and/or lacrimal sac mass (36%). The tumors were divided into epithelial (82 cases) and nonepithelial (33 cases) neoplasms. Benign epithelial tumors included squamous and transitional cell papillomas (32), oncocytomas (4), and benign mixed tumors (2). The malignant epithelial neoplasms included squamous cell carcinoma (22), transitional cell carcinoma (5), adenocarcinoma (4), mucoepidermoid (3), adenoid cystic (3), and poorly differentiated carcinoma (1). The nonepithelial tumors consisted of fibrous histiocytoma (13), lymphoid lesions (10), malignant melanoma (6), hemangiopericytoma (1), lipoma (1), granulocytic sarcoma (1), and neurofibroma (1). Review of the literature, including our own series, discloses a 55% malignancy rate for tumors originating in the lacrimal sac. Malignant epithelial neoplasms, especially invasive transitional cell carcinoma, often recur locally and can metastasize and be fatal. Epithelial malignancies tend to grow along the epithelium of the lacrimal drainage system, and thus cure is dependent on a wide surgical excision of the tumor and of the entire lacrimal drainage system (canaliculi, sac, and nasolacrimal duct) combined with a lateral rhinostomy and radiation therapy. PMID:7947444

Stefanyszyn, M A; Hidayat, A A; Pe'er, J J; Flanagan, J C

1994-09-01

2

Endolymphatic sac tumor and otalgia  

PubMed Central

Otalgia is a common complaint seen by general practitioners, but its etiology is vast. Rarely, otalgia could be secondary to a neoplasm. We describe a case of otalgia and ear discharge in which the imaging revealed a rare neoplasm, an endolymphatic sac tumor, which contributed to the patient's symptoms. The primary diagnosis was made via characteristic imaging features that were later confirmed by histology.

Kershen, Michael L.; Skaggs, Lauren; Bhatki, Amol; Gilbert, Steven C.; Gomez, Conan E.; Opatowsky, Michael J.

2013-01-01

3

Endolymphatic sac tumor and otalgia.  

PubMed

Otalgia is a common complaint seen by general practitioners, but its etiology is vast. Rarely, otalgia could be secondary to a neoplasm. We describe a case of otalgia and ear discharge in which the imaging revealed a rare neoplasm, an endolymphatic sac tumor, which contributed to the patient's symptoms. The primary diagnosis was made via characteristic imaging features that were later confirmed by histology. PMID:23543975

Zarghouni, Mehrzad; Kershen, Michael L; Skaggs, Lauren; Bhatki, Amol; Gilbert, Steven C; Gomez, Conan E; Opatowsky, Michael J

2013-04-01

4

Nonepithelial tumors of the lacrimal sac.  

PubMed

Lacrimal sac tumors are rare and mostly of epithelial origin. We conducted a clinicopathologic study of 35 cases of nonepithelial tumors of the lacrimal sac. These tumors included 13 fibrous histiocytomas, one hemangiopericytoma, one lipoma, ten lymphoid lesions, eight malignant melanomas, one granulocytic sarcoma, and one neurofibroma. Except for one 9-year-old child with fibrous histiocytoma, all neoplasms involved adults (age range, 27 to 90 years). The most common initial signs and symptoms were epiphora, chronic inflammation, or lacrimal mass. A bloody nasal discharge and bleeding from the punctum occurred in a patient with malignant melanoma. In none of the patients was the clinical diagnosis of a lacrimal sac tumor made preoperatively. Some of the nonepithelial neoplasms of the lacrimal sac can be life-threatening; therefore, early diagnosis and treatment are important. PMID:7977578

Pe'er, J J; Stefanyszyn, M; Hidayat, A A

1994-11-15

5

Primary yolk sac tumor of seminal vesicle: a case report and literature review  

PubMed Central

Background Yolk sac tumor (endodermal sinus tumor) is a rare malignant germ cell tumor arising in the testis or ovary. Extragonadal yolk sac tumor is even rarer and has only been described in case reports. Due to the rarity of the tumors, the appropriately optimal treatment remains unclear. We report a case of yolk sac tumor in the seminal vesicle. Case A 38-year-old Asian male presented with gross hematuria and hemospermia. Transrectal ultrasound scan showed a solid mass in the left seminal vesicle and the scrotal sonography showed no abnormalities. Bilateral seminal vesicles were resected, and histopathological examination showed a typical pattern of yolk sac tumor (YST). The patient responded poorly to comprehensive treatment of radiotherapy, chemotherapy and surgeries, developed systemic multiple metastases, and died of cachexia one and half years after diagnosis.

2012-01-01

6

Primary pure gastric yolk sac tumor  

PubMed Central

We describe here a case of pure gastric yolk sac tumor (YST). A 62-year-old patient underwent gastrectomy with D2 dissection. The histological report confirmed the diagnosis of YST and that two of the 14 regional lymph nodes removed were metastatic. Three courses of PEB regimen chemotherapy were delivered subsequently. Three months later the patient experienced dysphagia from stenosis of the anastomosis and a computerized tomography scan showed tumor recurrence with peritoneal nodules; the patient died one year after surgery. The origin of gastric YST is unclear but involvement of migrating germ cells during embryonic development or multipotential neoplastic protoepithelial cells of the gastric mucosa have been suggested. Generally the prognosis of gastric YST is poor and the standard therapeutic approach beyond surgery is still uncertain.

Magni, Elena; Sonzogni, Angelica; Zampino, Maria Giulia

2010-01-01

7

[Microglia arise from extra-embryonic yolk sac primitive progenitors].  

PubMed

Microglia are the resident macrophage population of the central nervous system (CNS). Adequate microglia function is crucial for the homeostasis of the CNS in health and disease, as they represent the first line of defence against pathogens, contributing to immune responses, but are also involved in tissue repair and remodeling. It is therefore crucial to better understand microglia origin and homeostasis. Much controversy remains regarding the nature of microglial progenitors, as the exact contribution and persistence of embryonic and post-natal hematopoietic progenitors to the adult microglial pool in the steady state remained unclear. In this study, we show that post-natal hematopoietic progenitors do not significantly contribute to microglia homeostasis in the adult brain in mice. In vivo lineage tracing studies established that adult microglia derives from primitive hematopoietic progenitors that arise before embryonic day 8. These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically-derived microglial progenitors for the treatment of various brain disorders. PMID:21880259

Ginhoux, Florent; Merad, Miriam

2011-08-31

8

Papillary Endolymphatic Sac Tumor: A Case Report  

PubMed Central

Glandular tumors involving the middle ear are rare and distinguishing between adenoma and adenocarcinoma remains difficult. A distinct subclass of these tumors demonstrates microscopic papillary architecture and has a propensity to erode the petrous bone and extend intracranially. The term “aggressive papillary middle ear tumor” has recently been proposed to describe this more invasive type of middle ear tumor. These tumors cause symptoms even when microscopic in size. Although histologically benign, they have been locally destructive with frequent intracranial extension and patients may die of uncontrolled local disease. These tumors do not metastasize but there is single case report of drop metastasis to the spine in the literature. Hence this tumor must be distinguished from other benign tumors of the middle ear. These rare neoplasms constitute a distinct pathological entity and deserve wider recognition.

Arava, S.; Soumya, R. M.; Chitragar, S.; Safaya, R.; Chandrashekhar, S. H.; Thakar, Alok

2012-01-01

9

Spinal cord compression of primary extragonadal giant yolk sac tumor  

Microsoft Academic Search

Study design:Case report.Objective:To report an adult male patient with a primary extragonadal giant yolk sac tumor presenting with acute spinal cord compression.Setting:Faculty of Medicine, University of Dicle, Diyarbakir, Turkey.Method:A 31-year-old man was referred to our department with a diagnosis of Pott's disease, a complaint of back pain and gait difficulty for 2 weeks. Neurological examination showed spastic paraparesis and hypoesthesia

A Guzel; M Tatli; D Belen; H Seckin

2007-01-01

10

Yolk sac tumor in a patient with transverse testicular ectopia  

PubMed Central

Transverse testicular ectopia (TTE) is a rare anomaly in which both testes descend through a single inguinal canal. We report a case of yolk sac tumor in the ectopic testis of a patient with TTE. A 24-year-old man presented to our hospital with a left inguinal-mass, right cryptorchidism and elevated alpha-fetoprotein (AFP). A left herniotomy 3 years earlier demonstrated both testes in the left scrotum, one above another positionally. Four months ago, a left scrotal mass appeared and radical orchiectomy of both testes revealed testicular yolk sac tumor of the ectopic testis. An enlarging left inguinal-mass appeared 2 months ago and he was referred to our hospital. Laboratory data showed an elevation of AFP (245.5 ng/ml) and a 46 XY karyotype. He underwent bilateral retroperitoneal lymph node dissection and simultaneous left inguinal mass dissection. Histopathologic examination revealed a diagnosis of recurrent yolk sac tumor in the left inguinal mass. The retroperitoneal lymph node was not enlarged and, on histopathology, was not involved. The patient has now been followed up for 8 months without evidence of biochemical or radiological recurrence.

2011-01-01

11

Incidental perivascular epithelioid cell tumor in an inguinal hernia sac.  

PubMed

Perivascular epithelioid tumors (PEComa) are uncommon mesenchymal neoplasms demonstrating positivity for muscular and melanocytic immuno-markers. Included in this category are angiomyolipoma, lymphangioleiomyomatosis, and clear cell sugar tumors. Lesions which do not fit into these categories are classified as "not otherwise specified". We present a case of an incidentally discovered PEComa within inguinal hernia sac contents in a 70-year-old woman. It consisted of spindled and epithelioid cells with bland oval nuclei, small nucleoli and clear to light eosinophilic cytoplasm. There was no atypia or mitoses. The lesion was strongly positive for HMB45 and smooth muscle actin. Pelvic soft tissue and peritoneal PEComas are rarely reported in literature and very little is known about their prognosis. We discuss the immunohistochemistry, differential diagnosis, and pathogenesis of PEComas. PMID:23870603

Wang, Tao; Voogjarv, Harry; Vajpeyi, Rajkumar

2013-06-14

12

Endolymphatic sac tumor: case report and review of the literature  

PubMed Central

Endolymphatic sac tumor (ELST) is a rare neoplasm which can be encountered sporadically or in Von Hippel-Lindau (VHL) disease. Here we report a sporadic case of ELST in 31-year-old man. Neither the symptoms nor a family history of VHL disease were found in the patient. CT imaging demonstrated an expansile lytic lesion of the mastoid process of the left petrous bone. MR scanning revealed a 5.2 cm × 4.7 cm × 4.2 cm mass which showed hyperintensity on T1- and T2-weighted images. Histologic sections showed a papillary, cystic or glandular architecture. The papillary and glandular structures were lined by a single layer of flattened cuboidal-to-columnar cells. The stroma of the papillary fronds was richly vascularized and chronically inflamed. The tumor showed diffusely positive reactivity with cytokeratin (Pan), cytokeratin 19, cytokeratin 5/6, cytokeratin 7, EMA, vimentin, CD56, and NSE and also showed variable reactivity with glial fibrillary acidic protein (GFAP) and VEGF. The Ki-67 immunostain showed a proliferation index of < 1%. Because the mass was large, it was difficult to extirpate surgically. After surgery, the patient underwent gamma-knife radiosurgery for residual tumor. The findings indicate that ELST is a rare neoplasm with benign histopathological appearance and clinically destructive behavior. Because of the rarity of this tumor, it can easily be confused with other tumors such as paraganglioma, middle ear adenoma, adenocarcinoma, papillary carcinoma of thyroid or choroid plexus papilloma. Owing to its locally aggressive nature, it is difficult to extirpate surgically when it is large. Virtual Slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7973320646763012

2012-01-01

13

A case of intraocular yolk sac tumor in a child and its pathogenesis.  

PubMed

While yolk sac tumor is one of the most common malignant germ cell tumors occurring in young children, it is rarely found in extragonadal sites. We report a case of intraocular yolk sac tumor in a 4-year-old boy. The diagnosis was confirmed by histologic examination and by the rapid normalization of serum alpha-fetoprotein level following enucleation. We propose that yolk sac cells can potentially migrate into the eye at 22 days of embryonic life during neural tube formation, when the head and tail of the neuropore open contemporaneously and communicate with the amniotic cavity. PMID:20006831

Fujino, Takahiro; Okamura, Akiko; Hatsukawa, Yoshikazu; Nakayama, Keiko; Inoue, Masami; Nakayama, Masahiro

2009-12-01

14

Mixed Germ Cell Tumor with Extensive Yolk Sac Tumor Elements in the Frontal Lobe of an Adult  

PubMed Central

Intracranial nongerminomatous germ cell tumors (NGGCTs) in unusual locations are extremely rare. Here, we report a case of a yolk sac tumor in the frontal lobe in a middle-aged patient. A 42-year-old man was admitted to our hospital for headache and nausea. Magnetic resonance imaging (MRI) showed an enhanced mass lesion with a marked cyst component. The serum alpha-fetoprotein (?FP) level was extremely high. Histological examination of specimens after subtotal removal revealed a primary mixed germ cell tumor with extensive yolk sac tumor elements, often referred to as an intracranial “yolk sac tumor.” The preoperative diagnosis of NGGCTs in unusual age and locations is extremely difficult. Clinicians should consider the possibility of NGGCTs, including yolk sac tumors, when intracranial tumors with unusual MRI findings are encountered.

Takahashi, Toshihide; Ishikawa, Eiichi; Masuda, Yosuke; Yamamoto, Tetsuya; Sato, Taiki; Shibuya, Makoto; Matsumura, Akira

2012-01-01

15

Giant Cell Tumor Arising from Anterior Arc of the Rib  

PubMed Central

A primary giant cell tumor of the rib is very rare. The most common site of a giant cell tumor arising from the rib is the posterior arc. A giant cell tumor arising from the anterior arc of the rib is extremely rare. The treatment of a giant cell tumor of the rib is not well defined. Generally, a complete surgical resection is performed in a patient with a primary giant cell tumor of the rib. We report a case of a giant cell tumor arising from the anterior arc of the rib that was treated with a wide excision and chest wall reconstruction.

Heo, Woon; Min, Ho-Ki; Jun, Hee Jae; Hwang, Youn-Ho

2013-01-01

16

Oral extragonadal yolk sac tumor in a patient with Aicardi syndrome: putative origin and differential diagnosis.  

PubMed

We report, for the first time, a primary oral presentation of a germ cell yolk sac tumor in a 4-year-old girl with Aicardi syndrome. The diagnosis, differential diagnosis, and histogenesis are discussed. PMID:22225777

Burch-Smith, Rhonda; Ordonez, Nelson G; Ginsberg, Lawrence E; Ater, Joann L; El Naggar, Adel K

2012-01-04

17

Primary Yolk Sac Tumor of the Omentum: A Case Report and Literature Review  

PubMed Central

Yolk sac tumor (YST) is a rare malignant tumor originating from germ cells. YST normally originates from the gonads, rarely occurring in extragonadal sites. We report a 35-year-old man with YST arising in the omentum, which is the first reported case of a primary YST of the omentum in an adult male. The patient presented to the community hospital with abdominal distension. A CT scan showed thickening of the omentum with ascites. The patient underwent open biopsy of the omental mass. The Pathology Department of the hospital could not make a definitive diagnosis at that time, and the tumor was considered a cancer of unknown primary (CUP) origin with features of primary colorectal cancer based on the immunohistochemistry (IHC) findings of the biopsy specimen (CK7–/CK20+ and CDX-2+). He was then referred to our hospital. We found that serum ?-fetoprotein was abnormally elevated to 7,144 ng/ml (normal <10.0), and reevaluation of the biopsy specimen revealed microcystic or reticular patterns of tumor cells with Schiller-Duval bodies typical of YST. The present case suggests that IHC is a very useful diagnostic tool for subtyping CUP but should be interpreted in the context of clinical and morphological findings.

Harano, Kenichi; Ando, Masashi; Sasajima, Yuko; Yunokawa, Mayu; Yonemori, Kan; Shimizu, Chikako; Tamura, Kenji; Katsumata, Noriyuki; Tsuda, Hitoshi; Fujiwara, Yasuhiro

2012-01-01

18

Primary paratesticular yolk sac tumor: A case report and review of literature  

PubMed Central

Paratesticular germ cell tumors are extremely rare. A 12-month-old boy with yolk sac tumor involving only the paratesticular tissue is reported. Pre-operatively raised alpha fetoprotein levels fell to normal levels after high inguinal orchiectomy. This appears to be the youngest and only the 3rd case reported in the English literature.

Lyngdoh, Toijam Soni; Menon, Prema; Jain, Richa; Das, Ashim

2013-01-01

19

Flap reconstruction and hyperbaric oxygen therapy in the management of temporal bone osteoradionecrosis in an endolymphatic sac tumor: case report.  

PubMed

Endolymphatic sac tumors (ELSTs) are rare neuroectodermal neoplasms arising within the posterior petrous bone. We present a case of a 21-year-old man who presented with a 6-month history of intermittent morning headaches, fatigue, diplopia, and gait ataxia. Imaging and surgical pathology identified an adenocarcinoma of the endolymphatic sac compressing the cerebellum and brain stem. The tumor and multiple metastases were treated with surgery, radiation, and radiosurgery. Following insertion of a ventriculoperitoneal shunt for hydrocephalus, he developed symptomatic tension pneumocephalus secondary to radionecrosis of his petrous bone, requiring flap reconstruction and use of a programmable shunt valve complemented by hyperbaric oxygen (HBO) therapy. We document here a young patient with a rare adenocarcinoma of the endolymphatic sac. This case is unique for its initial presentation without any vestibuloauditory symptoms. Metastatic spread of ELSTs is also rare. While osteoradionecrosis (ORN) of the temporal bone has been reported previously in patients with nasopharyngeal carcinoma, this is the first time it has been presented in the context of an ELST. Tension pneumocephalus is a rare complication of skull base ORN. This is the first reported use of a programmable shunt valve and HBO therapy in the management of tension pneumocephalus. PMID:23984214

Guha, Daipayan; Menard, Cynthia; Evans, Wayne; Gentili, Fred; Zadeh, Gelareh

2011-07-21

20

Flap Reconstruction and Hyperbaric Oxygen Therapy in the Management of Temporal Bone Osteoradionecrosis in an Endolymphatic Sac Tumor: Case Report  

PubMed Central

Endolymphatic sac tumors (ELSTs) are rare neuroectodermal neoplasms arising within the posterior petrous bone. We present a case of a 21-year-old man who presented with a 6-month history of intermittent morning headaches, fatigue, diplopia, and gait ataxia. Imaging and surgical pathology identified an adenocarcinoma of the endolymphatic sac compressing the cerebellum and brain stem. The tumor and multiple metastases were treated with surgery, radiation, and radiosurgery. Following insertion of a ventriculoperitoneal shunt for hydrocephalus, he developed symptomatic tension pneumocephalus secondary to radionecrosis of his petrous bone, requiring flap reconstruction and use of a programmable shunt valve complemented by hyperbaric oxygen (HBO) therapy. We document here a young patient with a rare adenocarcinoma of the endolymphatic sac. This case is unique for its initial presentation without any vestibuloauditory symptoms. Metastatic spread of ELSTs is also rare. While osteoradionecrosis (ORN) of the temporal bone has been reported previously in patients with nasopharyngeal carcinoma, this is the first time it has been presented in the context of an ELST. Tension pneumocephalus is a rare complication of skull base ORN. This is the first reported use of a programmable shunt valve and HBO therapy in the management of tension pneumocephalus.

Guha, Daipayan; Menard, Cynthia; Evans, Wayne; Gentili, Fred; Zadeh, Gelareh

2011-01-01

21

Ovarian mixed germ cell tumor with yolk sac and teratomatous components in a dog.  

PubMed

Mixed germ cell tumors of the ovary have rarely been reported in veterinary species. A 3-year-old intact female Labrador Retriever dog was presented for lethargy, abdominal distention, and a midabdominal mass. An exploratory laparotomy revealed a large (23 cm in diameter) left ovarian tumor and multiple small (2-3 cm in diameter) pale tan masses on the peritoneum and abdominal surface of the diaphragm. Histological examination of the left ovary revealed a mixed germ cell tumor with a yolk sac component with rare Schiller-Duval bodies and a teratomatous component comprised primarily of neural differentiation. The abdominal metastases were solely comprised of the yolk sac component. The yolk sac component was diffusely immunopositive for cytokeratin with scattered cells reactive for ?-fetoprotein and placental alkaline phosphatase. Within the teratomatous component, the neuropil was diffusely immunopositive for S100, neuron-specific enolase, and neurofilaments with a few glial fibrillary acidic protein immunopositive cells. Ovarian germ cell tumors may be pure and consist of only 1 germ cell element or may be mixed and include more than 1 germ cell element, such as teratoma and yolk sac tumor. PMID:23604259

Robinson, Nicholas A; Manivel, J Carlos; Olson, Erik J

2013-04-19

22

Ewing's Sarcoma of the Lesser Sac Masquerading as a Pancreatic Tumor  

PubMed Central

Extraosseous Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is an uncommon, aggressive, and malignant tumor with a poor patient outcome. Its occurrence in the lesser sac is a rare event and to the best of our knowledge, has not been previously described. The present case was clinically and radiologically misdiagnosed as a pancreatic tumor/gastrointestinal stromal tumor. Histopathology revealed a tumor with "small round cells" that were positive for CD99, confirming the diagnosis of ES/PNET. This report highlights the importance of considering Ewing's sarcoma in the differential diagnosis of intraabdominal, extraintestinal masses.

Rao, Lakshmi; Rodrigues, Gabriel; Suresh, B P

2012-01-01

23

Ovarian Sertoli-Leydig Cell Tumor, Endometrioid-Like Yolk Sac Tumor, and Y-Chromosomal Material  

Microsoft Academic Search

Sertoli-Leydig cell tumors (SLCTs) are rare neoplasms, accounting for less than 0.2% of ovarian tumors. The endometrioid-like variant of yolk sac tumor (YST) is very rare, and the most extensive series reported only 8 cases. We present a case of ovarian SLCT with endometrioid-like YST in a patient with a 46,XX karyotype with Y-chromosomal material. A 26-year-old woman had undergone

Ugo De Giorgi; Daniele Turci; Emilia Crisanti; Maria Grazia Cantù; Anna Cappellini; Maurizio Marangolo

2003-01-01

24

Glomus tumor of uncertain malignant potential arising in the bronchus  

PubMed Central

Glomus tumor is usually a small, benign tumor and typically occurs in the dermis or subcutis or soft tissue of the extremities and rarely in the visceral locations. Its occurrence in the main bronchus is extremely rare. The current case reported a 30-year-old woman with dyspnea on exertion and hemoptysis, she had a glomus tumor which has large size, deep location and exhibits an infiltrative margin as well as increased atypical mitotic figures. These characteristics suggest malignant behavior. However, there is little data regarding glomus tumors arising in the bronchus, the need for caution in diagnosing this case as a malignant glomus tumor must be highlighted. Therefore, the diagnosis of bronchial glomus tumor of uncertain malignant potential was favored. To the best of our knowledge, both the type and the location of this glomus tumor are extremely rare. Accumulation of more cases are needed to clarify their diagnosis and significance since there is little data regarding glomus tumors arising in the bronchus.

2013-01-01

25

ARISE  

NSDL National Science Digital Library

This web site of project ARISE, American Renaissance in Science Education, advocates the Physics First philosophy. It includes a detailed curriculum for science in grades 9-12 that puts a physics class at the foundation. Additional information supporting the Physics First philosophy is also available at this site.

Lederman, Leon

2003-10-31

26

Left ovarian gonadoblastoma with yolk sac tumor in a young woman.  

PubMed

Gonodoblastomas with ovarian germ cell tumors other than dysgerminoma coexists very rarely with yolk sac tumor (YST). Because of this rarity, we report a case of gonadoblastoma with YST. An 18-year-old female patient was admitted to our hospital with an abdomino-pelvic mass. Ultrasonographical examinations revealed a 15X14 cm heterogenous pelvic mass with calcific foci in the left adnexal area. Macroscopically, the resected mass was oval and measured 18X15X15 cm and weighed 3150 gm. Histological examination showed both gonadoblastic and YST areas. There were many gonadoblastic nests in the subcapsular areas of the tumor. The gonadoblastic nests were composed of large and small cells. The YST areas showed enteric differentiation and numerous hyaline globules. Immunohistochemical examination may help in the diagnosis of these gonadoblastoma with YST. PMID:20551554

Gelincik, Ibrahim; Ozen, Suleyman; Bayram, Irfan

27

Intestinal type of mucinous borderline tumor arising from mixed epithelial and stromal tumor of kidney  

Microsoft Academic Search

We report a mucinous borderline tumor arising from a mixed epithelial and stromal tumor of left kidney (MESTK). The patient\\u000a was an 82-year-old woman who presented with gross hematuria and recurrent urinary tract infection for years. The patient had\\u000a a cytoscopy with a retrograde pyelogram, which indicated a dilated left kidney with a central mass lesion. Subsequently, she\\u000a underwent a

Peiguo G. Chu; Sean K. Lau; Lawrence M. Weiss; Zhong Jiang

2009-01-01

28

Potentially lethal damage repair and its inhibitory effect of caffeine in two yolk sac tumor cell lines with different radiosensitivities  

Microsoft Academic Search

Purpose: In order to investigate the role of potentially lethal damage repair (PLDR) in cellular radiosensitivity, PLDR and its inhibitory effect by caffeine was examined. In addition, cell cycle distribution was also examined. Materials and methods: Two rat yolk sac tumor cell lines, NMT-1 and NMT-1R, with different radiosensitivities in vitro were used. The capacity for PLDR was examined using

Tetsuo Akimoto; Norio Mitsuhashi; Hiroko Matsumoto; Hideyuki Sakurai; Katsuya Maebayashi; Keiko Higuchi; Miwako Nozaki; Hideo Niibe

1999-01-01

29

Olfactory Ensheathing Cell Tumor Arising from the Olfactory Mucosa  

PubMed Central

We report a rare case of olfactory ensheathing cell tumor. A female presented a large soft mass extending medially to the olfactory cleft and laterally to the middle meatus in the left nasal cavity. Imaging studies confirmed a cystic mass extending superiorly into the frontal lobe, indicating that the tumor arouse from the olfactory mucosa. A subtotal resection was achieved through an endoscopic endonasal approach without operative complications. Immunohistochemically constituent cells were diffusely positive for S-100 protein, but olfactory ensheathing cell tumor was diagnosed by negative staining for Leu7 (CD57). This case indicates that olfactory ensheathing cell tumor should be included in differential diagnoses for the olfactory cleft tumors.

Ogino-Nishimura, Eriko; Nakagawa, Takayuki; Mikami, Yoshiki; Ito, Juichi

2012-01-01

30

Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors  

PubMed Central

Interleukin-27 (IL-27) is a pleiotropic cytokine but its immunosuppressive effects predominate during many in vivo immunological challenges. Despite this, evidence from tumor cell line transfer models suggested that IL-27 could promote immune responses in the tumor context. However, the role of IL-27 in immunity against tumors that develop in situ and in tumor immunosurveillance remain undefined. In this study, we demonstrate that tumor development and growth are accelerated in IL-27 receptor ? (Il27ra)-deficient mice. Enhanced tumor growth in both carcinogen-induced fibrosarcoma and oncogene-driven mammary carcinoma was associated with decreased interferon-? production by CD4 and CD8 T cells and increased numbers of regulatory T-cells (Treg). This is the first study to show that IL-27 promotes protective immune responses against endogenous tumors, which is critical as the basis for future development of an IL-27 based therapeutic agent.

Natividad, Karlo D. T.; Junankar, Simon R.; Mohd Redzwan, Norhanani; Nair, Radhika; Wirasinha, Rushika C.; King, Cecile; Brink, Robert; Swarbrick, Alexander; Batten, Marcel

2013-01-01

31

Establishment and Characterization of an Ovarian Yolk Sac Tumor Cell Line Reveals Possible Involvement of Nkx2.5 in Tumor Development  

Microsoft Academic Search

Objective: Ovarian yolk sac tumor (YST) is rare and highly malignant. Up to the present, there have been no cell lines of human ovarian YST constructed and, therefore, no studies on their cell function. The purpose of this study was to establish a human ovarian YST cell line to be able to identify a target for novel molecular-based therapy. Methods:

Kiyosumi Shibata; Hiroaki Kajiyama; Eiko Yamamoto; Mikio Terauchi; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa

2008-01-01

32

The stage I yolk sac tumor of testis in children younger than 2 years, chemotherapy or not?  

PubMed

Yolk sac tumor is the most frequent germ cell tumor of testis in children. For stage I yolk sac tumor of testis in children younger than 2 years, high inguinal orchiectomy alone has been the standard treatment, with a cure rate of at least 75%. Here, we compare the treatment results of receiving chemotherapy or no chemotherapy after orchiectomy, to analyze the role of chemotherapy. From February 1987 to January 1997, 22 children younger than 2 years, with stage I yolk sac tumor of testis, were included in the study. All patients had high inguinal orchiectomy without retroperitoneal lymphadenectomy. Initial diagnostic imaging studies included computed tomographic scan of abdomen, chest radiography, and long bone survey. Clinical stage I was defined as a tumor completely resected with no evidence of local regional lymph node involvement or distant metastases. Serum alpha-fetoprotein (AFP) was assessed at diagnosis. After orchiectomy, diagnosis, and staging, patients were stratified into two treatment groups, with or without chemotherapy, according to the decision of the parents. Ten children received chemotherapy consisting of cisplatin, vinblastine, and bleomycin (PVB, modified "Einhorn regimen") for 12 weeks. The remaining 12 patients were followed up according to a "wait and see" policy. Determination of AFP was performed monthly during the first postoperative year, every other month during the second year, every 3 months during the third year, every 6 months during the fourth year, and yearly until the fifth postoperative year at least. The duration of follow-up ranged from 3 months to 119 months (median, 53 months). The Kaplan-Meier plot estimated an overall survival rate of 91.6% at 7 years after diagnosis. Among the 12 patients without chemotherapy, 2 children had relapses at 4 and 6 months after diagnosis, respectively. One was cured with PVB chemotherapy. The other patient died with refractory lung metastasis, in spite of intensive multimodality salvage therapy. The Kaplan-Meier plot showed a survival rate of 80% at 7 years and a relapse-free survival rate of 81.8% at 5 years after diagnosis. All children receiving chemotherapy were alive and free from relapse. There was no significant treatment-related toxicity. Our results may suggest that PVB chemotherapy after orchiectomy is an affective and safe regimen for stage I yolk sac tumor of testis in children younger than 2 years. Instead of four courses of PVB as used here, two or three courses could be enough. To elucidate the necessity for chemotherapy and to determine the number of courses of PVB needed (if chemotherapy is given), a randomized study of more cases is warranted. PMID:9615319

Liu, H C; Liang, D C; Chen, S H; Liu, F L; Chang, P Y; Sheu, J C; Wang, N L

33

Precocious puberty secondary to a mixed germ cell-sex cord-stromal tumor associated with an ovarian yolk sac tumor: a case report  

PubMed Central

Introduction Ovarian tumors are the least common cause of sexual precocity in girls. Mixed germ cell-sex cord-stromal tumors associated with a yolk sac tumor of the ovary are rare neoplasms, of which only a small number of well-documented cases have been described so far. Here, we report precocious puberty in a four-year-old Egyptian girl caused by a mixed germ cell-sex cord-stromal tumor associated with a yolk sac tumor of the ovary. Case presentation A four-year-old Egyptian girl was referred to our pediatric endocrinology unit for evaluation of bilateral breast budding, pubic hair and vaginal bleeding. On examination, we found that her breast enlargement and pubic hair were compatible with Tanner III. A thorough workup revealed a large mass in her right ovary. Magnetic resonance imaging ofher brain showed that her pituitary gland was normal. A hormonal assay revealed high levels of estradiol, 280 to 375pmol/L; progesterone, 5.3?nmol/L; testosterone 38.9?pg/mL; and androstenedione, 4.1?ng/mL. Her basal and stimulated levels of luteinizing hormone and follicle-stimulating hormone were low. Tumor markers levels were high, with a total inhibin of 1,069U/L and an alpha-fetoprotein of 987??g/L. Her chromosomes were normal (46XX). Our patient underwent an explorative laparotomy and a solid tumor localized to her right ovary was identified. A right salpingo-oophorectomy was performed and the histopathological diagnosis was a mixed germ cell-sex cord-stromal tumorwith a yolk sac tumor of the ovary. Postoperatively, she was started on treatment with chemotherapy. Our patient is doing well without evidence of tumor recurrence or metastasis during eight months of postoperative follow-up. Conclusion Although a mixed germ cell-sex cord-stromal tumor associated with a yolk sac tumor of the ovary is a rare occurrence, it should be considered in the differential diagnosis for a prepubescent girl with an abdominal mass and precocious puberty.

2012-01-01

34

Tumors Arising in SCID Mice Share Enhanced Radiation Sensitivity of SCID Normal Tissues  

Microsoft Academic Search

We addressed the question of whether cancers arising in an abnor mally radiation sensitive normal tissue are also abnormally sensitive to ionizing irradiation. Germ line mutation-carrying mice with an en hanced radiation sensitivity of the normal tissue, the severe combined immunodeficient (SCID), and normally radiation sensitive mice (C3H) were used to study the sensitivity of normal and tumor tissues in

Wilfried Budach; Alan Hartford; Danielle Gioioso; Jill Freeman; Alphonse Taghian; Herman D. Suit

35

Complex regulation of prothymosin alpha in mammary tumors arising in transgenic mice  

Microsoft Academic Search

Expression of prothymosin a (PTA) has been related to cell proliferation, both normal and pathological. PTA has also been proposed to be a target of the c-myc protooncogene. To study PTA mRNA levels during pathological cell growth, and especially the effect of the activation of specific oncogenes on PTA expression, we have studied its expression in tumors that arise in

Lourdes Loidi; Tomás García-caballero; Anxo Vidal; Juan Zalvide; Rosalía Gallego; Fernando Domínguez

1999-01-01

36

Evaluation of an anal sac adenocarcinoma tumor in a Spitz dog  

PubMed Central

A 9-year-old emasculated male Spitz with tenesmus and constipation had a subcutaneous mass at the left ventral aspect of the anus with history of polyuria and polydipsia. A complete blood cell count, serum biochemistry panel, and urinalysis (cystocentesis sample) were evaluated. Abnormalities in the serum biochemistry panel included a mildly elevated serum cholesterol concentration (7.28 mmol/L; reference interval, 2.70–5.94 mmol/L), increased serum alkaline phosphatase activity (184 U/L; reference interval, 9–90 U/L), alanine transaminase (122 U/L; reference interval, 5–60 U/L) activity and aspartate aminotransferase (80 U/L; reference interval, 5–55 U/L) activity, severe increased total calcium concentration (16.3 mg/dL; reference interval, 8.2–12.4 mg/dL or 9.3–11.4 mg/dL), and decreased total calcium concentration (3.4 mg/dL, reference interval, 2.5–5.6mg/dL). Furthermore, testing revealed an increased intact parathyroid hormone concentration (38.6 pmol/L; reference interval, 3–17 pmol/L). On cytologic and histopathologic examinations, various types of cells were observed. Most of the cells were oval to polygonal and had elliptical or elongate nuclei and a moderate amount of pale to basophilic cytoplasm. The remaining cells had round to oval nuclei and pale to basophilic cytoplasm. Cells of both types were loosely adhered to each other and were arranged in rosette-like structures. Both neoplastic cell types had fine homogenous chromatin and either a small indistinct nucleolus or no visible nucleolus. Mild anisokaryosis and anisocytosis were observed. Histologically, the mass consists of glandular structures formed by cuboidal cells admixed with bundles of spindle cells. Based on location and histologic features, the final diagnosis was adenocarcinoma of the apocrine gland of the anal sac, which should be included as a cytologic differential diagnosis when spindle cells and typical epithelial cells are observed in masses in the region of the anal sac of dogs.

Javanbakht, Javad; Tavassoli, Abbas; Sabbagh, Atefeh; Hassan, Mehdy Aghamohammmad; Samakkhah, Shohreh Alian; Shafiee, Radmehr; Lakzian, Ali; Ghalee, Vahideh Rahmani; Gharebagh, Sonia Shoja

2013-01-01

37

First Description of a Primitive Neuroectodermal Tumor Arising in the Nose  

PubMed Central

We report the case of a 12-year-old girl, who consulted us with one-year history of an 8?mm nose lesion that was painless and firm upon palpation. The lesion was resected conservatively. Immunohistochemistry was in favor of a primitive neuroectodermal tumor (PNET)/Ewing's sarcoma lesion, excluding epithelial, lymphoid, and other tumors. After a second resection, our patient was referred to chemotherapy and has already undergone 9 cycles out of 14. The patient is to date with no evidence of persistent or recurrent disease. To our knowledge, this is the first description of a PNET arising in the nose.

Rizk, Habib; Khazzaka, Aline; Sebaaly, Amer; Cherfan, Maguy; Tomb, Roland; Sarkis, Riad

2013-01-01

38

von Hippel-Lindau disease: Deafness due to a non-MRI-visible endolymphatic sac tumor despite targeted screening.  

PubMed

Abstract Objective: Endolymphatic sac tumours (ELSTs) of the inner ear occur in 16% of patients with the hereditary tumor syndrome von Hippel-Lindau disease (vHL). ELSTs of all sizes can cause irreversible hearing loss which can, however, be prevented through early diagnosis and treatment. We aim to emphasize the challenges of prophylactic ELST screening and to explore the role of audiometry in pre-symptomatic ELST screening. Design: For a period of 17 years our patient was screened for ELSTs with inner-ear MRI (magnetic resonance imaging), audiometry, and clinical interviews. Study sample: A male vHL patient who became deaf in one ear due to a radiologically undetectable ELST. Results: Despite annual MRIs, the ELST was not visible until four months after onset of deafness when it appeared as a 1.4 × 1.4 mm tumor mass. Although his hearing was objectively within normal limits for the first 14 years, a distinct pattern of low-frequency hearing loss could retrospectively be seen at all audiometries. Conclusions: Audiometry is a candidate screening tool for detection of non-symptomatic pre-MRI-visible ELSTs, and we have initiated an international collaborative study to further determine its application. At present, we suggest an ELST screening protocol of yearly audiological assessment and inner ear MRI. PMID:24003980

Binderup, Marie Louise Mølgaard; Gimsing, Steen; Kosteljanetz, Michael; Thomsen, Carsten; Bisgaard, Marie Luise

2013-09-05

39

Endometrial carcinoma with yolk sac tumor-like differentiation and elevated serum ?-hCG: a case report and literature review  

PubMed Central

Endometrial carcinoma with a germ cell tumor component is a rare event. Here we report a uterine neoplasm with a unique combination of endometrioid adenocarcinoma and mixed germ cell malignant elements. A 28-year-old woman with abnormal vaginal bleeding, an abdominal mass, and elevated alfa-fetoprotein and beta-human chorionic gonadotropin (?-hCG) levels had a history of biopsy of an omental mass and chemotherapy in another hospital one month before her referral to our department. Histologic examination of the mass removed from the omentum revealed an endometrioid adenocarcinoma with yolk sac tumor-like differentiation. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy, and removal of metastatic disease were then undertaken at our hospital. Postoperative chemotherapy was given. Eight months postoperatively, serum alfa-fetoprotein and ?-hCG rose again. Cases with primary yolk sac tumors of the endometrium or endometrial carcinoma with trophoblastic differentiation in the literature were reviewed.

Ji, Mingliang; Lu, Yan; Guo, Lina; Feng, Fengzhi; Wan, Xirun; Xiang, Yang

2013-01-01

40

Therapeutically targeting cyclin D1 in primary tumors arising from loss of Ini1.  

PubMed

Rhabdoid tumors (RTs) are rare, highly aggressive pediatric malignancies with poor prognosis and with no standard or effective treatment strategies. RTs are characterized by biallelic inactivation of the INI1 tumor suppressor gene. INI1 directly represses CCND1 and activates cyclin-dependent kinase (cdk) inhibitors p16(Ink4a) and p21(CIP). RTs are exquisitely dependent on cyclin D1 for genesis and survival. To facilitate translation of unique therapeutic strategies, we have used genetically engineered, Ini1(+/-) mice for therapeutic testing. We found that PET can be used to noninvasively and accurately detect primary tumors in Ini1(+/-) mice. In a PET-guided longitudinal study, we found that treating Ini1(+/-) mice bearing primary tumors with the pan-cdk inhibitor flavopiridol resulted in complete and stable regression of some tumors. Other tumors showed resistance to flavopiridol, and one of the resistant tumors overexpressed cyclin D1, more than flavopiridol-sensitive cells. The concentration of flavopiridol used was not sufficient to down-modulate the high level of cyclin D1 and failed to induce cell death in the resistant cells. Furthermore, FISH and PCR analyses indicated that there is aneuploidy and increased CCND1 copy number in resistant cells. These studies indicate that resistance to flavopiridol may be correlated to elevated cyclin D1 levels. Our studies also indicate that Ini1(+/-) mice are valuable tools for testing unique therapeutic strategies and for understanding mechanisms of drug resistance in tumors that arise owing to loss of Ini1, which is essential for developing effective treatment strategies against these aggressive tumors. PMID:21173237

Smith, Melissa E; Cimica, Velasco; Chinni, Srinivasa; Jana, Suman; Koba, Wade; Yang, Zhixia; Fine, Eugene; Zagzag, David; Montagna, Cristina; Kalpana, Ganjam V

2010-12-20

41

Atypical teratoid/rhabdoid tumor arising in a ganglioglioma: genetic characterization.  

PubMed

Atypical teratoid/rhabdoid tumor (AT/RT) is an uncommon, aggressive, embryonal pediatric brain tumor that almost always develops de novo and does not arise within, or evolve from, other brain tumor types. Although rhabdoid morphology can be seen in other tumor types, these are phenotypic mimics and, with only rare exceptions, do not manifest the INI-1 deletion at the 22q11.2 locus or the INI-1 nuclear protein loss that characterizes AT/RT. A few reports of AT/RT evolving from a low-grade ganglioglioma (GG) or pleomorphic xanthoastrocytoma have appeared. We present the case of a 6-year-old boy with a large right parietal mass whose tumor at initial presentation manifested 2 distinct components: GG with neoplastic neurons, low MIB-1 rate, and retention of INI-1 nuclear immunostaining (immunohistochemical) and, second, AT/RT with rhabdoid cells, polyphenotypic immunohistochemical expression, high MIB-1 rate, and loss of INI-1 nuclear expression. The 2 areas were separately assessed by fluorescence in situ hybridization for monosomy 22; monosomy 22 was identified in the AT/RT component but not in the GG areas. BRAF V600E mutation, a genetic abnormality seen in a significant percentage of pleomorphic xanthoastrocytomas and GGs, was assessed by polymerase chain reaction and identified in the tumor. Dual abnormalities of INI-1 loss and V600E BRAF mutation were identified in a cell culture line established from cerebrospinal fluid metastatic tumor cells. This cell line exhibited extremely rapid growth rate and rhabdoid morphology. Results suggest a postclonal modification in a subset of GG cells, with acquisition of INI-1 loss, confirming by biological methods what was previously suspected in rare reports of AT/RT evolving from other tumor types. PMID:22082607

Kleinschmidt-DeMasters, B K; Birks, Diane K; Aisner, Dara L; Hankinson, Todd C; Rosenblum, Marc K

2011-12-01

42

Impaired CXCL4 expression in tumor-associated macrophages (TAMs) of ovarian cancers arising in endometriosis  

PubMed Central

Inflammatory cells play important roles in progression of solid neoplasms including ovarian cancers. Tumor-associated macrophages (TAMs) contribute to angiogenesis and immune suppression by modulating microenvironment. Ovarian cancer develops occasionally on the bases of endometriosis, a chronic inflammatory disease. We have recently demonstrated differential expressions of CXCR3 variants in endometriosis and ovarian cancers. In this study, we showed impaired CXCL4 expression in TAMs of ovarian cancers arising in endometriosis. The expressions of CXCL4 and its variant CXCL4L1 were investigated among normal ovaries (n = 26), endometriosis (n = 18) and endometriosis-associated ovarian cancers (EAOCs) composed of clear cell (n = 13) and endometrioid (n = 11) types. In addition, four cases of EAOCs that contained both benign and cancer lesions contiguously in single cysts were investigated in the study. Western blot and quantitative RT-PCR analyses revealed significant downregulation of CXCL4 and CXCL4L1 in EAOCs compared with those in endometriosis. In all EAOCs coexisting with endometriosis in the single cyst, the expression levels of CXCL4 and CXCL4L1 were significantly lower in cancer lesions than in corresponding endometriosis. Histopathological study revealed that CXCL4 was strongly expressed in CD68+ infiltrating macrophages of endometriosis. In microscopically transitional zone between endometriosis and EAOC, CD68+ macrophages often demonstrated CXCL4? pattern. The majority of CD68+ TAMs in overt cancer lesions were negative for CXCL4. Collective data indicate that that CXCL4 insufficiency may be involved in specific inflammatory microenvironment of ovarian cancers arising in endometriosis. Suppression of CXCL4 in cancer lesions is likely to be attributable to TAMs in part.

Furuya, Mitsuko; Tanaka, Reiko; Miyagi, Etsuko; Kami, Daisuke; Nagahama, Kiyotaka; Miyagi, Yohei; Nagashima, Yoji; Hirahara, Fumiki; Inayama, Yoshiaki; Aoki, Ichiro

2012-01-01

43

Juvenile granulosa cell tumor arising from intra-abdominal testis in newborn: case report and review of the literature.  

PubMed

In the present case, the neonate presented with a left-sided abdominal mass and an empty left scrotum. Abdominal ultrasonography showed well-defined cystic formation, and laparotomy revealed a tumor arising from an intra-abdominal left testis. The carcinoembryonic antigen and neuron-specific enolase levels were within normal limits, and the serum ?-human chorionic gonadotropin and ?-fetoprotein levels were within age-related normal values. The findings from the immunochemistry tests confirmed the diagnosis. PMID:22088573

Partalis, Nikolaos; Tzardi, Maria; Barbagadakis, Sophia; Sakellaris, George

2011-11-16

44

Desmoid tumor arising around the distal tubing of a cerebrospinal fluid shunt.  

PubMed

A case of desmoid tumor in the abdominal wall as a cause of malfunction of a cerebrospinal fluid shunt is presented. The desmoid tumor arose from the reactive fibrose tissue formed around the silastic distal tubing and caused the catheter to become disconnected from the reservoir. PMID:2944238

González-Darder, J; Alacreu, J B; Garcia-Vázquez, F

1986-10-01

45

Mammary cystosarcoma with mature adipose stromal differentiation (lipophyllodes tumor) arising in a lipomatous hamartoma.  

PubMed

This report documents an uncommon variant of benign cystosarcoma phyllodes with mature adipose stromal differentiation, for which the term lipophyllodes tumor is proposed. Origin of this unusual tumor within a lipomatous hamartoma was confirmed by histologic and mammographic observations. The lesion developed in a 40-year-old woman 2 months post partum, and she remained well after treatment by biopsy. Lipophyllodes tumor, which features mature adipose tissue in much of the stromal component of a cystosarcoma, should not be mistaken for a malignant neoplasm. Complete excision is adequate therapy. PMID:8285842

Rosen, P P; Romain, K; Liberman, L

1994-01-01

46

Sudden Unilateral Vision Loss Arising from Calcified Amorphous Tumor of the Left Ventricle  

PubMed Central

Calcified amorphous tumor of the heart is a very rare non-neoplastic intracavitary mass. The clinical presentation is similar to that of other cardiac masses. The precise cause and best approach to treatment remain unclear. We describe a case of cardiac calcified amorphous tumor presenting with refractory unilateral vision loss that was successfully treated by surgical excision. To our knowledge, this is only the 2nd reported case of retinal arterial embolism due to cardiac calcified amorphous tumor in the English-language literature.

Nazli, Yunus; Colak, Necmettin; Atar, Inci Asli; Alpay, Mehmet Fatih; Haltas, Hacer; Eryonucu, Beyhan; Cakir, Omer

2013-01-01

47

Wilms tumor arising in a child with X-linked nephrogenic diabetes insipidus  

Microsoft Academic Search

We report on a child with X-linked nephrogenic diabetes insipidus (NDI) who developed Wilms tumor (WT). Nephrogenic diabetes\\u000a insipidus is caused by mutations of the arginine vasopressin receptor (AVPR2) or aquaporin-II (AQP2) genes. Wilms tumor is also genetically heterogeneous and is associated with mutations of WT1 (15–20%), WTX (20–30%) and other loci. The boy presented at 5 months with failure

Reyhan El-Kares; Pierre-Alain Hueber; Miriam Blumenkrantz; Diana Iglesias; Kim Ma; Nada Jabado; Daniel G. Bichet; Paul Goodyer

2009-01-01

48

Ewing's sarcoma/primitive neuroectodermal tumor arising from the adrenal gland: a case report and literature review.  

PubMed

We report a rare case of Ewing's sarcoma (ES)/primitive neuroectodermal tumor (PNET) arising from the adrenal gland. A 17-year-old Japanese woman presented with left upper abdominal pain and high fever. Computed tomography and magnetic resonance imaging revealed a 15×10 cm tumor replacing the adrenal gland. Preoperative diagnosis was an adrenocortical carcinoma. Resection of the tumor was performed. We obtained the final diagnosis of ES/PNET by immunohistochemical molecular study with positive staining for the MIC2 gene product (CD99) and a Ewing sarcoma breakpoint region 1 (EWSR1) gene rearrangement. Local recurrence was observed one month after the surgery. The patient was then treated with systemic chemotherapy and localized radiotherapy. PMID:24158076

Sasaki, Takeshi; Onishi, Takehisa; Yabana, Tadashi; Hoshina, Akira

49

Intracranial Germ Cell Tumors  

Microsoft Academic Search

\\u000a Germ cell tumors originating from the gonads may also occur in the central nervous system (CNS). They arise from primordial\\u000a germ cells that were trapped within neural tissue during the process of migration at the time of early embryogenesis [20].\\u000a Intracranial germ cell tumors include six subtypes classified by the World Health Organization: germinoma, embryonal carcinoma,\\u000a yolk sac tumor (endodermal

Kyu-Chang Wang; Seung-Ki Kim; Sung-Hye Park; Ji Hoon Phi; Byung-Kyu Cho

50

Human skin carcinoma arising from kidney transplant-derived tumor cells  

PubMed Central

Tumor cells with donor genotype have been identified in human skin cancer after allogeneic transplantation; however, the donor contribution to the malignant epithelium has not been established. Kidney transplant recipients have an increased risk of invasive skin squamous cell carcinoma (SCC), which is associated with accumulation of the tumor suppressor p53 and TP53 mutations. In 21 skin SCCs from kidney transplant recipients, we systematically assessed p53 expression and donor/recipient origin in laser-microdissected p53+ tumor cells. In one patient, molecular analyses demonstrated that skin tumor cells had the donor genotype and harbored a TP53 mutation in codon 175. In a kidney graft biopsy performed 7 years before the skin SCC diagnosis, we found p53+ cells in the renal tubules. We identified the same TP53 mutation in these p53+ epithelial cells from the kidney transplant. These findings provide evidence for a donor epithelial cell contribution to the malignant skin epithelium in the recipient in the setting of allogeneic kidney transplantation. This finding has theoretical implications for cancer initiation and progression and clinical implications in the context of prolonged immunosuppression and longer survival of kidney transplant patients.

Verneuil, Laurence; Varna, Mariana; Ratajczak, Philippe; Leboeuf, Christophe; Plassa, Louis-Francois; Elbouchtaoui, Morad; Schneider, Pierre; Sandid, Wissam; Lebbe, Celeste; Peraldi, Marie-Noelle; Sigaux, Francois; de The, Hugues; Janin, Anne

2013-01-01

51

Hypercalcemia Associated with a Malignant Brenner Tumor Arising from a Mature Cystic Teratoma  

PubMed Central

A 60-year-old woman presented with abdominal pain and weight loss and was found to have serum calcium of 15.0 mg/dl. Serum parathyroid hormone-related peptide (PTHrP) returned elevated. Imaging suggested bilateral mature cystic teratomas. Her hypercalcemia was treated initially with intravenous saline, as well as intramuscular and subcutaneous calcitonin. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, and final pathology revealed malignant Brenner tumor in association with a mature cystic teratoma. Her postoperative PTHrP returned less than assay, and her total and ionized calcium fell below normal, requiring supplemental calcium and vitamin D. At follow-up one month after discharge, her calcium had normalized. We present the first reported case of hypercalcemia occurring in association with a malignant Brenner tumor. Malignancy-associated hypercalcemia occurs via four principal mechanisms: (1) tumor production of PTHrP; (2) osteolytic bone involvement by primary tumor or metastasis; (3) ectopic activation of vitamin D to 1,25-(OH)2 vitamin D, and (4) ectopic production of parathyroid hormone. PTHrP-mediated hypercalcemia is the most common mechanism and was responsible in this case. In patients with paraneoplastic hypercalcemia who undergo surgical treatment, close monitoring and management of serum calcium is necessary both pre- and postoperatively.

Honigberg, Michael C.; Bradford, Leslie S.; Prabhakar, Anand M.; Hariri, Lida P.; Goodman, Annekathryn

2012-01-01

52

TERATOMA WITH MALIGNANT TRANSFORMATION: DIVERSE MALIGNANT HISTOLOGIES ARISING IN MEN WITH GERM CELL TUMORS  

Microsoft Academic Search

PurposeTeratoma with malignant transformation refers to a form of germ cell tumor in which a somatic teratomatous component becomes morphologically malignant and develops aggressive growth. We evaluated the spectrum of histologies, chromosomal abnormalities and clinical outcome in patients with teratoma with malignant transformation.

Robert J. Motzer; Alison Amsterdam; Victor Prieto; Joel Sheinfeld; V. V. V. S. Murty; Madhu Mazumdar; George J. Bosl; R. S. K. Chaganti; Victor E. Reuter

1998-01-01

53

Hypercalcemia associated with a malignant brenner tumor arising from a mature cystic teratoma.  

PubMed

A 60-year-old woman presented with abdominal pain and weight loss and was found to have serum calcium of 15.0 mg/dl. Serum parathyroid hormone-related peptide (PTHrP) returned elevated. Imaging suggested bilateral mature cystic teratomas. Her hypercalcemia was treated initially with intravenous saline, as well as intramuscular and subcutaneous calcitonin. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, and final pathology revealed malignant Brenner tumor in association with a mature cystic teratoma. Her postoperative PTHrP returned less than assay, and her total and ionized calcium fell below normal, requiring supplemental calcium and vitamin D. At follow-up one month after discharge, her calcium had normalized. We present the first reported case of hypercalcemia occurring in association with a malignant Brenner tumor. Malignancy-associated hypercalcemia occurs via four principal mechanisms: (1) tumor production of PTHrP; (2) osteolytic bone involvement by primary tumor or metastasis; (3) ectopic activation of vitamin D to 1,25-(OH)(2) vitamin D, and (4) ectopic production of parathyroid hormone. PTHrP-mediated hypercalcemia is the most common mechanism and was responsible in this case. In patients with paraneoplastic hypercalcemia who undergo surgical treatment, close monitoring and management of serum calcium is necessary both pre- and postoperatively. PMID:23185165

Honigberg, Michael C; Bradford, Leslie S; Prabhakar, Anand M; Hariri, Lida P; Goodman, Annekathryn

2012-11-06

54

Galectin-3 as a Potential Therapeutic Target in Tumors Arising from Malignant Endothelia  

Microsoft Academic Search

Angiosarcoma (ASA) in humans and hemangiosarcoma (HSA) in dogs are deadly neoplastic diseases charac- terized by an aggressive growth of malignant cells with endothelial phenotype, widespread metastasis, and poor response to chemotherapy. Galectin-3 (Gal-3), a B-galactoside-binding lectin implicated in tumor pro- gression and metastasis, endothelial cell biology and angiogenesis, and regulation of apoptosis and neo- plastic cell response to cytotoxic

Kim D. Johnson; Olga V. Glinskii; Valeri V. Mossineb; James R. Turk; Thomas P. Mawhinneyb; Douglas C. Anthony; Carolyn J. Henry; Virginia H. Huxley; Gennadi V. Glinsky; Kenneth J. Pienta; Avraham Raz; Vladislav V. Glinsky

2007-01-01

55

Elevated frequency of loss of heterozygosity in mammary tumors arising in mouse mammary tumor virus/neu transgenic mice.  

PubMed

Loss of heterozygosity (LOH) analysis was performed on 62 mammary tumors that were induced in (BALB/c x C57BL/6)F1 mouse mammary tumor virus/neu transgenic mice. Eighty-six simple sequence length polymorphism markers were used to cover all of the somatic chromosomes. Frequency of LOH was observed to be significant for chromosomes 4 (50%), 19 (32%), and 8 (21%). On chromosome 4, at least three distinct regions of allelic deletions could be identified: one proximal to 22 cM; the second close to the p16INK4a/p15INK4b locus, which is commonly deleted in various tumors; and the third one in the proximity of Mom1. The frequency of LOH on chromosome 19 was the same for the four markers used. Our data suggested the presence of two distinct LOH loci, one proximal to 47 cM and the other at the distal region. On chromosome 8, possibly two distinct LOH loci could be recognized, one around 52 cM and the other one at 67 cM or distal to it. These regions map close to E-cadherin (Cdh1) and M-cadherin (Cdh15) loci, respectively. Because LOH sites are thought to harbor tumor suppressor genes, this allelotype screening has allowed the mapping of putative tumor suppressor genes that may be implicated, in collaboration with the erbB-2/neu oncogene, in the development of mammary tumors in these transgenic mice. PMID:10344755

Cool, M; Jolicoeur, P

1999-05-15

56

[A case report of ball valve syndrome caused by the gastrointestinal stromal tumor arising from the muscularis mucosae in gastric fornix].  

PubMed

An 83-year-old woman who was admitted to other hospital, was consulted us because of continuous tarry stool and abdominal fullness. On upper endoscopy, the submucosal tumor from greater curvature of gastric fornix invaginated into the duodenal bulbus, showing so-called "ball valve syndrome (BVS)". As the tumor incarcerted again on the following endoscoopy, she underwent laparoscopic partial gastrectomy. The submucosal tumor was diagnosed histologically as gastrointestinal stromal tumor (GIST) arising from the muscularis mucosae. This is the first report that GIST arising from the muscularis mucosae in gastric fornix showed a BVS. PMID:18772574

Ishikawa, Chisato; Watari, Jiro; Ueno, Nobuhiro; Konno, Yoko; Sato, Ryu; Moriichi, Kentaro; Okamoto, Kotaro; Tanabe, Hiroki; Fujiya, Mikihiro; Tokusashi, Yoshihiko; Miyokawa, Naoyuki; Kohgo, Yutaka

2008-09-01

57

Malignant peripheral nerve sheath tumor arising from the colon in a newborn: report of a case and review of the literatures  

Microsoft Academic Search

A malignant peripheral nerve sheath tumor (MPNST) is a rare neoplasm arising from peripheral nerve sheath. Here, we report the first case of MPNST arising in the colon and also the youngest case of MPNST in the gastrointestinal tract. The patient was a 2-day-old neonate with symptoms and signs of intestinal obstruction. The patient had no family history or stigmata

Young-Joon Lee; HyeongGon Moon; Soon-Tae Park; Woo-Song Ha; Sang-Gyeong Choi; Soon-Chan Hong; Young-Tae Joo; Chi-Young Jeong; Eun-Jung Jung

2006-01-01

58

Better grade of tumor differentiation of oral squamous cell carcinoma arising in background of oral submucous fibrosis.  

PubMed

Oral submucous fibrosis (OSMF) is a potentially malignant disorder of the oral cavity. Most of the people affected by OSMF are betel quid chewers. It is characterized by epithelial atrophy and progressive accumulation of collagen fibers in lamina propria and submucosa of the oral mucosa. 7.6% of OSMF cases undergo oral squamous cell carcinoma (OSCC) transformation of which majority display low grade of tumor differentiation. In the present paper, a hypothesis has been proposed to correlate atrophy, turnover rate and surface keratization in OSMF with degree of tumor differentiation in OSCC. A novel hypothesis for epithelial atrophy in OSMF has also been emphasized. High proliferative activity and basal cell hyperplasia in conjunction with rapid exfoliation of superficial cells and epithelial atrophy suggest that epithelial turnover rate is very high in OSMF. Presence of surface keratinized layer in this situation suggests faster maturation or differentiation of epithelium in OSMF. Thus, the epithelial cells are genetically programmed for high turnover rate and faster differentiation or maturation to form keratin. During malignant transformation of OSMF, the transformed epithelial cells may retain the genetic memory of faster differentiation and maturation resulting in better grade of tumor differentiation. The well differentiated OSCC has good prognosis, better survival rate and less chances of recurrence of regional and distant metastasis. Studies are needed to explore the biomarkers or molecular markers associated with carcinogenesis like genetic instability, oncogenes, tumor suppressor genes and angiogenesis in OSCC associated with OSMF. If investigated in the suggested direction, it might provide some important clues about the pathogenesis of OSCC arising in background of OSMF and for the future development of treatment strategies. PMID:23891040

Sarode, Sachin C; Sarode, Gargi S

2013-07-26

59

Sac phosphatase domain proteins.  

PubMed Central

Advances in our understanding of the roles of phosphatidylinositol phosphates in controlling cellular functions such as endocytosis, exocytosis and the actin cytoskeleton have included new insights into the phosphatases that are responsible for the interconversion of these lipids. One of these is an entirely novel class of phosphatase domain found in a number of well characterized proteins. Proteins containing this Sac phosphatase domain include the yeast Saccharomyces cerevisiae proteins Sac1p and Fig4p. The Sac phosphatase domain is also found within the mammalian phosphoinositide 5-phosphatase synaptojanin and the yeast synaptojanin homologues Inp51p, Inp52p and Inp53p. These proteins therefore contain both Sac phosphatase and 5-phosphatase domains. This review describes the Sac phosphatase domain-containing proteins and their actions, with particular reference to the genetic and biochemical insights provided by study of the yeast Saccharomyces cerevisiae.

Hughes, W E; Cooke, F T; Parker, P J

2000-01-01

60

Recurrent lacrimal sac papilloma: case report.  

PubMed

Tumors of the lacrimal sac are rare. Benign papillomas comprise approximately 40% of all neoplasms of the lacrimal drainage system. They often present insidiously with symptoms of dacryostenosis or dacryocystitis. Recurrent bouts of dacryocystitis and nasolacrimal duct obstruction were reported in a 35-year-old man over a period of 13 years. A medial canthal mass was noted in the 6th year after the onset of symptoms. A tumor was discovered incidentally during surgical intervention for presumed dacryostenosis. Surgical removal of the tumor and dacryocystorhinostomy were performed. The histopathologic report turned out to be benign papiloma. Local recurrences occurred during the follow-up period. In addition to surgical excision, we applied cryotherapy and CO2 laser to prevent further recurrence. This case we presented the characteristic recurrence of lacrimal sac papilloma and implied the possibility of tumor occurrence in a patient with recurrent dacryocystitis. We must bear in mind that a recurrent dacryocystitis may be a presentation of a lacrimal sac tumor, because early diagnosis and aggressive treatment can prevent recurrence and result in a cure. PMID:10835807

Hung, S L; Ma, L

2000-02-01

61

Fibrous histiocytoma of the lacrimal sac.  

PubMed

Fibrous histiocytoma is a rare tumor whose ocular manifestations usually involve the orbit or, less commonly, the conjunctiva and ciliary body. We have treated two patients with fibrous histiocytoma of the lacrimal sac. One, a 62-year-old woman who had had hordeolum and trachoma, had a visual acuity of counting fingers at 1 m in the affected eye. The fellow eye had been enucleated ten years previously. The entire lacrimal sac was surgically removed and a brown cystic tumor measuring 28 x 12 x 10 mm was found. The second patient, a 32-year-old man, had undergone an unsuccessful dacryocystectomy for epiphora. When he underwent a dacryocystorhinostomy some months later, a mass measuring 20 x 15 x 12 mm was found in the wall of the lacrimal sac. Microscopic examination of the two excised lacrimal sacs showed that the walls were thickened by cells resembling fibroblasts and by cells resembling histiocytes. The fibroblasts were characterized by collagen production, were fusiform or oval in shape, and were arranged in bundles. The histiocytes were larger and had abundant (and sometimes vacuolated) cytoplasm. All the cells appeared to be mature. PMID:6280504

Marback, R L; Kincaid, M C; Green, W R; Iliff, W J

1982-04-01

62

SAC: Sheffield Advanced Code  

NASA Astrophysics Data System (ADS)

The Sheffield Advanced Code (SAC) is a fully non-linear MHD code designed for simulations of linear and non-linear wave propagation in gravitationally strongly stratified magnetized plasma. It was developed primarily for the forward modelling of helioseismological processes and for the coupling processes in the solar interior, photosphere, and corona; it is built on the well-known VAC platform that allows robust simulation of the macroscopic processes in gravitationally stratified (non-)magnetized plasmas. The code has no limitations of simulation length in time imposed by complications originating from the upper boundary, nor does it require implementation of special procedures to treat the upper boundaries. SAC inherited its modular structure from VAC, thereby allowing modification to easily add new physics.

Griffiths, Mike; Fedun, Viktor; Mumford, Stuart; Gent, Frederick

2013-06-01

63

Synchronous primary carcinoid tumor and primary adenocarcinoma arising within mature cystic teratoma of horseshoe kidney: a unique case report and review of the literature  

PubMed Central

Background Malignant transformation of mature cystic teratoma is a rare complication. While any of the constituent tissues of a teratoma has the potential to undergo malignant transformation, squamous cell carcinoma is the most commonly associated malignancy. Renal carcinoid tumors are rare and frequently associated with horseshoe kidney and renal teratoma. Renal teratoma rarely presents together with carcinoid tumor or adenocarcinoma. To the best of our knowledge, there has never been a report of renal teratoma coexisting with both carcinoid tumor and adenocarcinoma. Methods Here, we present a unique and first case of synchronous primary carcinoid tumor and moderately differentiated adenocarcinoma arising within mature cystic teratoma of horseshoe kidney in a 50-year-old female. Lumbar spine X-ray, done for her complaint of progressive chronic low back pain, accidentally found a large calcification overlying the lower pole of the right kidney. Further radiologic studies revealed horseshoe kidney and a large multiseptated cystic lesion immediately anterior to the right renal pelvis with central calcification and peripheral enhancement. She underwent right partial nephrectomy. Results Macroscopically, the encapsulated complex solid and multiloculated cystic tumor with large calcification, focal thickened walls and filled with yellow-tan gelatinous material. Microscopically, the tumor showed coexistent mature cystic teratoma, moderately differentiated adenocarcinoma and carcinoid tumor. Immunohistochemically, alpha-methylacyl-coenzyme A-racemase, calretinin, CD10 and thyroid transcription factor-1 were negative in all the three components of the tumor. The teratomatous cysts lined by ciliated epithelium showed strong staining for cytokeratin 7 and pancytokeratin, and those lined by colonic-like epithelium showed strong staining for CDX2, cytokeratin 20 and pancytokeratin, but both were negative for calretinin. Additionally, the teratomatous cyst wall showed strong staining for smooth muscle actin, and weak staining for carbonic anhydrase IX, CD99, chromogranin and synaptophysin. The adenocarcinoma component was strongly positive for cytokeratin 7 and pancytokeratin, weakly positive for synaptophysin and CD56, and negative for carbonic anhydrase IX, CD99, CDX2, chromogranin, cytokeratin 20 and smooth muscle actin. The carcinoid tumor component was strongly positive for CD56, chromogranin and synaptophysin, weakly positive for pancytokeratin, and negative for carbonic anhydrase IX, CD99, CDX2, cytokeratin 7, cytokeratin 20 and smooth muscle actin. She received no adjuvant therapy and is alive without evidence of disease six months after diagnosis and surgery. Conclusion This unique and first case herein presented with synchronous primary carcinoid tumor and primary adenocarcinoma arising within mature cystic teratoma of horseshoe kidney emphasizes the need for thorough sectioning and entire submission for histologic evaluation of mature cystic teratomas, in order to avoid missing multiple additional histogenetically distinct neoplasms.

Armah, Henry B; Parwani, Anil V; Perepletchikov, Aleksandr M

2009-01-01

64

[Testicular germ cell tumor arising in the male with a chromosomal abnormality of 45,X/46,X,del(Y)].  

PubMed

A 25-year-old-man came to our outpatient clinic complaining of swelling of the left scrotal contents. He had a past history of 3 surgeries for hypospadia. His left testis was stony hard and testicular tumor was suspected. High orchiectomy was performed under general anesthesia. The pathological diagnosis was mixed type testicular germ cell tumor. Chromosomal analysis revealed a karyotype of 45,X/46,X,del(Y). Most of the long arm of the Y chromosome was missing. Prophylactic chemotherapy was performed. Treatment options for genetically high risk patients of testicular malignancies were discussed. PMID:22343745

Tomomasa, Hiroshi; Iiyama, Tetsuro; Okada, Hiroshi

2012-01-01

65

Burkitt lymphoma arising from lymphoplasmacytic lymphoma following acquisition of MYC translocation and loss of the ETV6 tumor suppressor gene.  

PubMed

Lymphoplasmacytic lymphoma is a mature B-cell lymphoma with variable plasmacytic differentiation that displays an indolent clinical course. Its transformation to a high-grade B-cell lymphoma may occur uncommonly. Although acquisition of a MYC translocation could result in transformation of a low-grade lymphoma into diffuse large B-cell lymphoma, Burkitt lymphoma, or B-lymphoblastic leukemia, to our knowledge the latter 2 transformations have not been well documented in lymphoplasmacytic lymphoma. We report the case of a 70-year-old woman with a 9-year history of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia who presented with rapid enlargement of a left neck mass and pancytopenia, which was diagnosed as Burkitt lymphoma with extensive bone marrow involvement. A series of histopathologic, molecular, and cytogenetic evaluations proved a cytogenetic evolution including t(8;14)(q24;q32)/MYC-IgH and identical clonal B-cell gene rearrangements from the 2 distinct lymphomas, confirming stage 4 aggressive Burkitt lymphoma arising from lymphoplasmacytic lymphoma. PMID:23276184

Peker, Deniz; Quigley, Brian; Qin, Dahui; Papenhausen, Peter; Zhang, Ling

2013-01-01

66

Primary intraspinal primitive neuroectodermal tumor: case report of a tumor arising from the sacral spinal nerve root and review of the literature.  

PubMed

Primary spinal primitive neuroectodermal tumor (PNET) is a rare condition, 18 cases of which have been reported in the literature. In general, this tumor is treated with surgery followed by radiotherapy and chemotherapy, but prognosis is still poor. An 18-year-old female patient with an intradural, extramedullary mass at L3-L5 levels is presented in this report. This is the first female patient with primary spinal PNET at lumbar region, second patient with spinal nerve root origin, and third one with intradural, extramedullary localization ever reported in the literature. After surgery, she was treated with craniospinal radiotherapy and four cycles of combination chemotherapy regimen consisting of vincristine, cyclophosphamide, doxorubicin alternated with ifosfamide, and VP-16. Currently, she is asymptomatic and alive at 25 months. The histopathologic, radiologic, and clinical findings of the patient are presented and relevant literature is reviewed. PMID:11943890

Yavuz, A Aydin; Yaris, Nilgun; Yavuz, Melek N; Sari, Ahmet; Reis, A Kadir; Aydin, Fazil

2002-04-01

67

Yolk sac tumour involving floor of mouth: case report.  

PubMed

Yolk sac tumour is a rare malignant tumour of germ cell origin that usually arises from the gonads. It is extremely rare in the head and neck. We present a case of a yolk sac tumour that involved the floor of the mouth in a 14-month-old Chinese girl. The diagnosis was confirmed by histological examination that showed characteristic Schiller-Duval bodies, and immunohistochemical examination that showed ?-fetoprotein being expressed within the cytoplasm of the neoplastic cells. The patient died 4 months postoperatively. To our knowledge, this is the first case of a yolk sac tumour of the floor of mouth that has been reported in an English journal. PMID:22560784

Zhang, Q; Huang, Y; Bao, C Y; Li, L J

2012-05-03

68

Pituitary carcinoma with endolymphatic sac metastasis.  

PubMed

Pituitary carcinoma is characterized by the presence of a metastatic lesion(s) in a location non-contiguous with the original pituitary tumor. The mechanism(s) of malignant transformation are not known. A 15 year-old male was diagnosed in 1982 with a pituitary macroadenoma and acromegaly (random GH 67 ng/ml and no suppression by oral glucose). His prolactin was normal between 18 and 23 ng/ml. Transcranial resection in July 1983 was followed by radiation therapy. The tumor was immunopositive for GH and prolactin. The proliferation MIB-1 index was 0-1 %. With aqueous Octreotide 100 mcg 4× daily both GH and IGF-1 became normal. The patient was lost to follow-up and was treated by his local physician. In 2001, his IGF-1 level was 1271 ng/ml, and his random GH was 1.8-2.4 ng/ml by ILMA despite progressive increase in the dose of Sandostatin LAR to 140 mg/month in divided doses. Prolactin remained normal or minimally increased between 15 and 25 ng/ml. In 2009 he was diagnosed with the tumor in the location of left endolymphatic sac. Histological examination showed low grade pituitary carcinoma strongly immunopositive for prolactin but negative for GH. MIB-1 antibody labeled 0-5 % cells. In 2012 endoscopic resection of the pituitary tumor remnant was attempted. Immunohistochemical stains were strongly immunopositive for both prolactin and GH, similar to his original pituitary tumor. The MIB-1 proliferation index was low from 0 to 1 %. To our knowledge this is the first case of pituitary carcinoma in the endolymphatic sac region. The dichotomy between the cell population of the pituitary lesion (GH/prolactin producing) and the metastasis (purely prolactin-producing) may suggest that the metastatic pituitary lesion derived from a clone distinct from the original one. PMID:23645293

Balili, Irida; Sullivan, Steven; McKeever, Paul; Barkan, Ariel

2013-05-01

69

Sinonasal teratocarcinosarcoma with yolk sac elements: a neoplasm of somatic or germ cell origin?  

PubMed

Sinonasal teratocarcinosarcoma is an uncommon, aggressive, morphologically heterogenous tumor composed of cells derived from the 3 somatic layers. A histogenetic origin from a multipotential adult somatic stem cell with divergent differentiation has been favored over a germ cell origin. This assumption has been based on the lack of germ cell elements and, until recently, the absence of demonstrable amplification of 12p. We report a case that exhibited foci of yolk sac elements with papillary structures and intracytoplasmic periodic acid-Schiff-positive, diastase-resistant, ?-fetoprotein-positive, hyaline globules. An expanded area of undifferentiated cells, likely precursor cells, in the basal layer of the overlying mucosal epithelium transitions into and merges with the immature epithelial, neuroepithelial, and mesenchymal components. These previously unreported histomorphological features support the hypothesis that this tumor is a teratomatous tumor arising from pluripotent embryonic stem cells in the basal layer of the sinonasal epithelium. That notion is further supported by fluorescence in situ hybridization cytogenetic analysis, which showed a distinct subpopulation of the tumor cells with an extra copy of chromosome 12p13. PMID:20952296

Thomas, Jaiyeola; Adegboyega, Patrick; Iloabachie, Kenny; Mooring, John Wesley; Lian, Timothy

2010-04-24

70

A Garlic Derivative, S-allylcysteine (SAC), Suppresses Proliferation and Metastasis of Hepatocellular Carcinoma  

PubMed Central

Background Hepatocellular carcinoma (HCC) is highly malignant and metastatic. Currently, there is no effective chemotherapy for patients with advanced HCC leading to an urgent need to seek for novel therapeutic options. We aimed to investigate the effect of a garlic derivative, S-allylcysteine (SAC), on the proliferation and metastasis of HCC. Methodology/Principal Findings A series of in vitro experiments including MTT, colony-forming, wound-healing, invasion, apoptosis and cell cycle assays were performed to examine the anti-proliferative and anti-metastatic effects of SAC on a metastatic HCC cell line MHCC97L. The therapeutic values of SAC single and combined with cisplatin treatments were examined in an in vivo orthotopic xenograft liver tumor model. The result showed that the proliferation rate and colony-forming abilities of MHCC97L cells were suppressed by SAC together with significant suppression of the expressions of proliferation markers, Ki-67 and proliferating cell nuclear antigen (PCNA). Moreover, SAC hindered the migration and invasion of MHCC97L cells corresponding with up-regulation of E-cadherin and down-regulation of VEGF. Furthermore, SAC significantly induced apoptosis and necrosis of MHCC97L cells through suppressing Bcl-xL and Bcl-2 as well as activating caspase-3 and caspase-9. In addition, SAC could significantly induce the S phase arrest of MHCC97L cells together with down-regulation of cdc25c, cdc2 and cyclin B1. In vivo xenograft liver tumor model demonstrated that SAC single or combined with cisplatin treatment inhibited the progression and metastasis of HCC tumor. Conclusions/Significance Our data demonstrate the anti-proliferative and anti-metastatic effects of SAC on HCC cells and suggest that SAC may be a potential therapeutic agent for the treatment of HCC patients.

Cheng, Qiao; Geng, Wei; Ling, Chang Chun; Li, Chang Xian; Liu, Xiao Bing; Ma, Yuen Yuen; Lo, Chung Mau; Poon, Ronnie T. P.; Fan, Sheung Tat; Man, Kwan

2012-01-01

71

Ear Tumors  

MedlinePLUS

... and causing hearing loss and a buildup of earwax. Such tumors include small sacs filled with skin ... ear. Ceruminoma (cancer of the cells that produce earwax) develops in the outer third of the ear ...

72

Case report of death from falling: Did heart tumor cause syncope?  

PubMed

A healthy man in his 30s was working on the balustrade of stairs on the second floor. He suddenly fell downstairs without saying anything. On emergency hospitalization, chest echogram showed left hemothorax. Cardiac echogram showed a floating mass from the mitral valve in the left ventricle and severe mitral regurgitation. Surgery for hemothorax and pulmonary contusion was immediately undertaken. However, bleeding from pulmonary contusion could not be controlled and he underwent cardiopulmonary arrest. Autopsy showed a white, elastic, pendulous mass in the left atrium and a white mass in the lower lobe of the left lung. Tumor histology showed a reticular pattern, Schiller-Duval bodies, eosinophilic hyaline globules, and positive staining for ?-fetoprotein. We diagnosed primary lung yolk sac tumor with metastatic intracardiac yolk sac tumor, a rare and highly malignant germ cell tumor. It usually arises in the ovaries and testes, and intracardiac yolk sac tumor is rare. Intracavitary tumors induce obstruction of inflow into and outflow from the ventricular cavity. The most common clinical presentation is dyspnea and syncope. In the present case, metastatic cardiac yolk sac tumor might have disturbed cardiac outflow and affected hemodynamics, probably causing syncope. Unfortunately, he was in a high place at that time and fell to receive pulmonary contusion that led to death. Autopsy may sometimes reveal latent diseases which might be related to the cause of death. We should perform autopsy thoroughly to diagnose not only the cause of death but also the factors leading to death. PMID:22081041

Yamamoto, Takuma; Takasu, Kosho; Emoto, Yuko; Shikata, Nobuaki; Matoba, Ryoji

2011-11-13

73

Surgical Treatment of Mucoepidermoid Carcinoma of the Lacrimal Sac.  

PubMed

Abstract Purpose: We report successful management of a case with high-grade mucoepidermoid carcinoma of the lacrimal sac managed by aggressive soft tissue and bony resection with adjuvant radiotherapy. Methods: Case report. Results: A 32-year-old man was referred to us with a two-year history of epiphora and slow-growing mass in the area of the lacrimal sac. On physical examination, a firm and nontender mass was visible overlying the area of the right lacrimal sac. Computed tomography and magnetic resonance imaging confirmed a 30?mm?×?15?mm, well-enhanced soft tissue mass occupying the lacrimal fossa and extending to include the nasolacrimal duct, and FNA biopsy of the mass demonstrated high-grade mucoepidermoid carcinoma. On this basis, the tumor, lacrimal sac, and nasolacrimal duct were removed en bloc with the frontal process of the maxilla, lateral nasal wall, lacrimal fossa, ethmoids, and anterior part of the medial orbital wall with two intraoperative frozen section examinations. Postoperatively, the patient received adjuvant radiotherapy. The clinical evaluation and positron emission tomography at 38 months showed recovery and no recurrence of the disease. Conclusions: MEC of the lacrimal sac is extremely rare and spreads locally in an aggressive manner. Despite the fact that orbital exenteration have generally been recommended for these tumors, radical surgical resections with external radiation therapy might be effective. In our case, despite the high-grade MEC, the patient underwent successful radical surgical excision and postoperative adjuvant external radiotherapy. As a result, we achieved an aesthetically satisfying result by preserving the eye and the vision. PMID:23758339

Yuksel, Dilek; Kosker, Mustafa; Saribas, Ferhat; Simsek, Saban

2013-06-12

74

Oxyphil cell adenoma (oncocytoma) of the lacrimal sac. Review of the literature.  

PubMed

A case of oncocytoma of the lacrimal sac is presented. An 84-year-old woman with a mass in the lacrimal sac area and epiphora was operated with excision. Histological and electron microscopic examination revealed it to be an oncocytic adenoma. Oncocytic tumours of the lacrimal sac are very rare and to our knowledge this is the 14th case to be reported. Oncocytomas are composed of polyhedric cells with abundant oxyphil cytoplasm which is granular and contains large numbers of abnormal mitochondria. Non-neoplastic oncocytes may arise from the secretory epithelium of the sac in various chronic inflammatory states. They may also occur at an old age, as a result of the normal aging process. PMID:7976277

Domanski, H; Ljungberg, O; Andersson, L O; Schele, B

1994-06-01

75

Performance Analysis of Wavelength Multiplexed Sac Ocdma Codes in Beat Noise Mitigation in Sac Ocdma Systems  

NASA Astrophysics Data System (ADS)

In this paper we investigate the use of wavelength multiplexed spectral amplitude coding (WM SAC) codes in beat noise mitigation in coherent source SAC OCDMA systems. A WM SAC code is a low weight SAC code, where the whole code structure is repeated diagonally (once or more) in the wavelength domain to achieve the same cardinality as a higher weight SAC code. Results show that for highly populated networks, the WM SAC codes provide better performance than SAC codes. However, for small number of active users the situation is reversed. Apart from their promising improvement in performance, these codes are more flexible and impose less complexity on the system design than their SAC counterparts.

Alhassan, A. M.; Badruddin, N.; Saad, N. M.; Aljunid, S. A.

2013-07-01

76

Determination of the Thecal Sac Ending Using Magnetic Resonance Imaging: Clinical Applications in Craniospinal Irradiation  

Microsoft Academic Search

Purpose : To determine level of the thecal sac ending in unaffected individuals of young age-group and in patients with cerebrospinal fluid (CSF) seeding tumor using Magnetic Resonance Imaging (MRI). Material and Method : MRI of the lumbosacral spine of 253 cases (age range 1-40 years) had been reviewed. Of these, 20 cases were known having CSF seeding tumors. Two

Sith Phongkitkarun

77

ALVAC-mediated gene transfer is efficient in lymphoid malignancies of T-and early B-cell origin, but not in tumors arising from mature B-cells.  

PubMed

Natural attenuation of ALVAC virus in mammals makes it an attractive vector for cancer vaccine therapy of immunocompromised hosts, such as patients with lymphoid malignancies. However, the transduction efficiency of ALVAC constructs in lymphoid tumors has not yet been characterized. We studied a wide spectrum of human T- and B-cell leukemia and lymphomas and found significant heterogeneity of the ALVAC-mediated gene product expression in these tumors. While ALVAC-B7.1, ALVAC-B7.2, or ALVAC-luciferase vectors effectively expressed recombinant genes in malignancies arising from T- or early B-cell precursors, negative or low expression of ALVAC recombinant genes occurred in tumors arising from mature B-cells. We showed that ALVAC-encoded B7.1 or B7.2 was continuously expressed on the infected, and subsequently irradiated, leukemia cells, and only cells with ALVAC-mediated expression of costimulatory molecules (but not unmodified leukemia cells or those infected with the ALVAC-parental vector) induced significant proliferation and IFN-gamma production by alloreactive T-cells. These data provide the rationale for clinical studies using the ALVAC vector system for gene transfer into lymphoid tumors of T- and early B-cell origin to render them more immunogenic, while alternative strategies should be considered for immunotherapy of mature B-cell malignancies. PMID:11676394

Gitelson, E; Ghose, A; Buckstein, R; Imrie, K; Lim, M S; Reis, M; Spaner, D; Tartaglia, J; Berinstein, N L

2001-09-01

78

Primary ductal adenocarcinoma of the lacrimal sac: the first reported case.  

PubMed

Primary lacrimal sac tumor is extremely rare, and moreover, glandular tumor is exceptional. Herein, we described the first documented case of primary ductal adenocarcinoma of the lacrimal sac. A 79-year-old Japanese female presented with persistent swelling of her left lower eyelid. Computed tomography demonstrated an irregular-shaped tumor involving the left lacrimal sac, lower eyelid, sinonasal tract, and internal side of the left orbit. Biopsy from the eyelid revealed a poorly differentiated adenocarcinoma. Histopathological study of the resected lacrimal sac tumor revealed an infiltrative neoplastic growth that was composed of cribriform structures with comedonecrosis. The neoplastic cells had relatively rich granular eosinophilic cytoplasm and large round to oval nuclei containing conspicuous nucleoli. The left cervical lymph nodes had metastatic carcinoma. Immunohistochemically, the neoplastic cells were diffusely positive for gross cystic disease fluid protein-15 and androgen receptor. Moreover, mammalian target of rapamycin (mTOR), 4E-BP1, and p4E-BP1 were expressed. According to these results, an ultimate diagnosis of primary ductal adenocarcinoma of the lacrimal sac was made. Only 9 cases of primary lacrimal sac adenocarcinoma have been reported, and this is the first reported case of ductal adenocarcinoma of the lacrimal sac. Ductal adenocarcinoma of the salivary gland shows an aggressive clinical course, and the present case had multiple cervical lymph node metastases. This report is the first to demonstrate that mTOR pathway proteins, which are central proteins involved in carcinogenesis, are activated in ductal adenocarcinoma. Therefore, mTOR inhibitor may be a potential candidate for treatment of this highly aggressive carcinoma. PMID:24040460

Ishida, Mitsuaki; Iwai, Muneo; Yoshida, Keiko; Kagotani, Akiko; Kohzaki, Hideaki; Arikata, Masahiko; Shimizu, Takeshi; Okabe, Hidetoshi

2013-08-15

79

SAC Headquarters Underground Command Center Cutaway Axonometric Offutt ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SAC Headquarters Underground Command Center - Cutaway Axonometric - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

80

Hyalinizing spindle cell tumor with giant rosettes arising in the lung: report of a case with FUS-CREB3L2 fusion transcripts.  

PubMed

Hyalinizing spindle cell tumor with giant rosettes (HSCT) is a very uncommon mesenchymal tumor that has similar morphological and biological features to the low-grade fibromyxoid sarcoma (LGFMS). Lung involvement of HSCT is extremely rare, and only one case has been reported in the English-language literature. Reported herein is a case of primary pulmonary HSCT that had FUS-CREB3L2 fusion transcripts, a product of characteristic chromosomal abnormality t(7;16)(q33;p11) of HSCT and LGFMS. The patient was a 50-year-old woman who had a large solitary mass in the lung. Histologically, it was composed of bland spindle cells with variable cellularity deposited in a densely hyalinized stroma alternating with myxoid areas. Characteristic collagen rosettes were scattered in the cellular areas. Reverse transcription-polymerase chain reaction (RT-PCR) assay using formalin-fixed, paraffin-embedded tissue detected FUS-CREB3L2 fusion transcripts. Despite its bland morphology, it is known as low-grade sarcoma and its recognition in the lung would be helpful for accurate diagnosis and proper management of this rare tumor. RT-PCR for detection of FUS-CREB3L2 fusion transcripts is a useful method for differential diagnosis of primary pulmonary HSCT. PMID:17295648

Kim, Lucia; Yoon, Yong Han; Choi, Suk-Jin; Han, Jee Young; Park, In Suh; Kim, Joon Mee; Chu, Young Chae; Kim, Ye Ji

2007-03-01

81

Sisters of the sinuses: cetacean air sacs.  

PubMed

This overview assesses some distinguishing features of the cetacean (whale, dolphin, porpoise) air sac system that may relate to the anatomy and function of the paranasal sinuses in terrestrial mammals. The cetacean respiratory tract has been modified through evolution to accommodate living in water. Lack of paranasal sinuses in modern cetaceans may be a diving adaptation. Bone-enclosed air chambers are detrimental, as their rigid walls may fracture during descent/ascent due to contracting/re-expanding air volumes. Flexible-walled "sinuses" (extracranial diverticula) are a logical adaptation to diving. Odontocetes (toothed whales) exhibit several pairs of paranasal air sacs. Although fossil evidence indicates that paranasal sinuses occur in archaeocetes (ancestors/relatives of living cetaceans), it is not known whether the paranasal sacs derive from these sinuses. Sac pigmentation indicates that they derived from invaginations of the integument. Unlike sinuses, paranasal sacs are not circumferentially enclosed in bone, and therefore can accommodate air volume changes that accompany diving pressure changes. Paired pterygoid sacs, located ventrally along the cetacean skull, connect the pharynx and middle ear cavities. Mysticetes (baleen whales) have a large midline laryngeal sac. Although cetacean air sacs do not appear to be homologous to paranasal sinuses, they may serve some analogous respiratory, vocal, or structural functions. For example, these sacs may participate in gas exchange, thermoregulation, resonance, and skeletal pneumatization. In addition, they may subserve unique aquatic functions, such as increasing inspiratory volume, mitigating pressure-induced volume change, air shunting to reduce respiratory dead space, and facilitating underwater sound production and transmission. PMID:18951477

Reidenberg, Joy S; Laitman, Jeffrey T

2008-11-01

82

Lipoblastoma arising from the submandibular region.  

PubMed

A lipoblastoma is a rare, benign tumor arising from embryonic white fat. The tumors occur primarily in infancy and early childhood and commonly arise from the limbs and the trunk, but neck involvement is extremely rare. Our case arose in a 22-month-old male presenting with a rapidly enlarging soft mass in the right submandibular area. Lipoblastoma was diagnosed by histologic evaluation, the mass was completely removed, and there was no recurrence at 1-year follow-up. PMID:18970913

Do, Nam-Yong; Cho, Sung-Il; Park, Jun Hee; Choi, Ji Yun

2008-11-01

83

Combined resection and multi-agent adjuvant chemotherapy for desmoplastic small round cell tumor arising in the abdominal cavity: report of a case.  

PubMed

Desmoplastic small round cell tumor (DSRCT) is a rare, highly aggressive malignancy with distinctive histological features: a nesting pattern of cellular growth within dense desmoplastic stroma, occurring in young population with male predominance. The mean survival period is only about 1.5-2.5 years. The tumor has co-expressed epithelial, muscle, and neural markers in immunohistochemical studies. This work reports a 27-year-old man presenting with hematemesis and chronic constipation. Serial studies including endoscopy, upper gastrointestinal series, abdominal computed tomography and barium enema study showed disseminated involvement of visceral organs. The patient underwent aggressive surgery and received postoperative adjuvant chemotherapy consisting of 5-fluorouracil, cyclophosphamide, etoposide, doxorubicin, and cisplatin. He survived without any disease for 20 mo after the surgery. No standard treatment protocol has been established. Aggressive surgery combined with postoperative multi-agent adjuvant chemotherapy is justified not only to relieve symptoms but also to try to improve the outcome in this advanced DSRCT young patient. PMID:16521199

Chang, Chang-Cheng; Hsu, Jun-Te; Tseng, Jeng-Hwei; Hwang, Tsann-Long; Chen, Han-Ming; Jan, Yi-Yin

2006-02-01

84

Müllerian adenosarcoma arising in a subserosal adenomyoma.  

PubMed

Müllerian adenosarcomas most commonly arise in the uterine corpus from the eutopic endometrium. Occasionally, they arise in the cervix, vagina, broad and round ligaments, and ovaries and rarely in extragenital sites, usually in association with endometriosis. The authors report a rare case of extraendometrial, intramural adenosarcoma of low grade arising from a subserosal adenomyoma in a 46-year-old woman who presented with vaginal bleeding. No evidence of eutopic endometrial origin was identified; the adenosarcoma showed only limited myometrial invasion and no serosal involvement. Because of its subserosal location, the tumor would be overstaged as IC (deeply myoinvasive) in the new FIGO staging system. Stage IC tumors would normally be considered for adjuvant treatment, which would be inappropriate in this case. To avoid overstaging and inappropriate treatment, it is important to recognize that adenosarcoma can, rarely, arise in adenomyomas (or adenomyosis). PMID:22820101

Elshafie, Mona; Rahimi, Siavash; Ganesan, Raji; Hirschowitz, Lynn

2012-07-20

85

Histopathology after Endolymphatic Sac Surgery for Meniere's Syndrome  

PubMed Central

Background The putative goal of sac surgery in Meniere’s syndrome is to promote the flow of endolymph from the labyrinth to the endolymphatic sac, and thereby relieving hydrops. There is scant published histopathological data whether sac surgery actually accomplishes this goal. Objective To determine if sac surgery relieves hydrops by examining the histopathologic changes in temporal bones obtained from individuals who had undergone sac surgery during life for Meniere’s syndrome. Methods Temporal bones were examined from 15 patients who had sac surgery. Data was collected on presence and severity of hydrops, histology of the sac, and whether the procedure relieved vertigo. Results The surgery failed to expose the sac in 5 cases; 4 of the 5 had relief from vertigo. The sac was exposed, but the shunt failed to reach the lumen of the sac in 8 cases; 4 of the 8 had relief from vertigo. The shunt was successfully placed within the lumen of the sac in two cases; both cases failed to experience relief from vertigo. Endolymphatic hydrops was present in all 15 cases. Conclusion Endolymphatic sac surgery does not relieve hydrops in patients with Meniere’s syndrome. Yet, sac surgery relieves vertigo in some patients, but the mechanism of such symptomatic relief remains unknown.

Chung, Jong Woo; Fayad, Jose; Linthicum, Fred; Ishiyama, Akira; Merchant, Saumil N.

2011-01-01

86

Range of Validity of SAC Method  

NASA Astrophysics Data System (ADS)

The SAC method is a semi-empirical method for analysing the emission lines of ions, having a complex spectrum, like Fe^+. The method and the assumptions it makes, are discussed. Radiative transfer calculations are needed to check their ranges of validity.

Friedjung, M.

87

Comparing and Contrasting NAEYC and SACS Accreditation  

ERIC Educational Resources Information Center

|The purpose of this paper is to describe, compare, and contrast an early childhood departmental accreditation process from the National Association for the Education of Young Children (NAEYC) and a college/university-wide accreditation process from the Southern Association of Colleges and Schools (SACS). The history of higher education…

Isaacs, Mary Ruth

2010-01-01

88

13. SAC command center, weather center, underground structure, building 501, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. SAC command center, weather center, underground structure, building 501, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

89

8. SAC command center underground structure, building 501, basement entry, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. SAC command center underground structure, building 501, basement entry, machine room, April 11, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

90

72. SAC control center underground structure lower floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

72. SAC control center underground structure lower floor plan, drawing number 32-02-03, dated 1 February 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

91

11. SAC command center, main operations area, underground structure, building ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. SAC command center, main operations area, underground structure, building 501, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

92

10. SAC command center, main operations area, underground structure, building ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. SAC command center, main operations area, underground structure, building 501, circa 1980 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

93

75. SAC control center underground structure middle floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

75. SAC control center underground structure middle floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

94

76. SAC control center underground structure upper floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

76. SAC control center underground structure upper floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

95

12. SAC command center, main operations area, underground structure, building ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. SAC command center, main operations area, underground structure, building 501, circa 1960 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

96

9. SAC command center, main operations area, underground structure, building ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. SAC command center, main operations area, underground structure, building 501, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

97

Intraoperative Sac Pressure Measurement During Endovascular Abdominal Aortic Aneurysm Repair  

Microsoft Academic Search

PurposeIntraoperative sac pressure was measured during endovascular abdominal aortic aneurysm repair (EVAR) to evaluate the clinical significance of sac pressure measurement.MethodsA microcatheter was placed in an aneurysm sac from the contralateral femoral artery, and sac pressure was measured during EVAR procedures in 47 patients. Aortic blood pressure was measured as a control by a catheter from the left brachial artery.ResultsThe

Hiroyuki Ishibashi; Tsuneo Ishiguchi; Takashi Ohta; Ikuo Sugimoto; Hirohide Iwata; Tetsuya Yamada; Masao Tadakoshi; Noriyuki Hida; Yuki Orimoto; Seiji Kamei

2010-01-01

98

Laparoscopic pancreatic cystgastrostomy: the lesser sac technique.  

PubMed

Management of pancreatic pseudocysts has remained largely unchanged during the past century. Excision and drainage procedures remain the mainstay of therapy for large, persistent, or symptomatic pseudocysts. Laparoscopic approaches to the management of pancreatic pseudocysts have been previously described. The lesser sac approach is an effective means of creating a hemostatic cystgastrostomy through a single posterior gastrotomy. This procedure is performed by creating a cystotomy and posterior wall gastrotomy through which an endoscopic stapler is applied. The cystotomy-gastrotomy is closed using laparoscopically placed sutures. An endoscope is inserted into the stomach and pseudocyst at the conclusion of the procedure to ensure an airtight anastomosis. The lesser sac approach to pancreatic cystgastrostomy allows for a minimally invasive approach to the management of pancreatic pseudocysts using a single gastrotomy. PMID:11444753

Roth, J S; Park, A E

2001-06-01

99

The cul-de-sac phenomena  

Microsoft Academic Search

96% of cul-de-sac entrances made by 36 rats exhibited homolaterality of turns inside and outside of the blind alley; i.e., the turns inside and outside of the alley were in the same direction. With symmetrically located paths the incidence of homolaterality reached 98.4%. The frequency of homolaterality of turns increased directly with the logarithm of the number of successive trials.

L. S. Tsai

1931-01-01

100

Thermomechanical reliability of SAC leadfree alloys  

Microsoft Academic Search

In this paper, thermo-mechanical reliability of four different low-silver SnAgCu (SAC) lead free alloys is investigated in a harsh thermal environment of -55 to 125°C. Four configuration of test boards were assembled all having identical 100 I\\/O, 0.8mm pitch chip array ball grid array (CABGA) packages. Previous researchers have demonstrated the superior performance of low-silver leadfree alloys in shock and

Pradeep Lall; Robert Hinshaw; Ranjit Pandher; Mahendra Harsha; Jeff Suhling

2010-01-01

101

The SAC-D/Aquarius mission  

NASA Astrophysics Data System (ADS)

The goal of the SAC-D/Aquarius Mission is to contribute to the understanding of the whole Earth system and the consequences of the natural and man-made changes in the environment of the planet. The measurements performed by this observatory shall contribute to a better interpretation of oceanic circulation and the prediction of its changes, as well as its effects on the Earth climate and the water cycle. The SAC-D/Aquarius Mission comprises the SAC-D satellite provided by CONAE, NASA Aquarius instrument for measuring sea salinity, CONAE instruments, included the New InfraRed Scanner Technology (NIRST) camera, the K-band radiometers, which will provided complementary surface temperature measurements, surface winds, rainfall and characteristics of sea ice. A high sensitivity Optical Camera and the Data Collection Transceptor complete the set of Argentine instruments that shall be designed and built by CONAE with the participation of other scientific organizations in the country. Another possible contributions are: the LAGRANGE instrument of the Italian Space Agency (ASI), devoted to observations of GPS satellite occultations in order to supply information about the atmosphere temperature, pressure and water vapor pressure contents and the SODAD instrument of the French Centre National d'Etudes Spatiales (CNES), for the measurement of the properties of micrometeorites and space debris. This set of instruments was defined taking into account the Cycles of Space Information II and III of the National Space Program, which refer to coastal and oceanic studies, sea-atmosphere-land interactions, global phenomena such as El Niño and emergency management This Mission will be positioned into orbit in September 2008, by a NASA provided Delta II spacecraft. The command, control, monitoring and data acquisition shall be in charge of CONAE's Córdoba Ground Station. The analysis and interpretation of data shall be performed by a considerable number of scientists, who have already held a first meeting with an attendance of over 70 professionals from our country and abroad, where subjects associated to dissemination and use of the SAC-D/Aquarius Mission results were discussed, in addition to the strictly scientific themes. In a second meeting, to be held next April, there will be also researchers from ESA's SMOS (Soil Moisture and Ocean Salinity) and NASA's HYDROS satellite missions in order to coordinate international working groups on sea salinity and soil moisture. The main characteristics of the SAC-D/Aquarius Mission and its instruments are reported in this paper.

Colomb, F. R.; Lagerloef, G.

102

Yolk Sac Tumour of the Cryptorchid Testis, with an Unusual Presentation -- Diagnosed by Fine Needle Aspiration Cytology  

PubMed Central

Yolk sac tumour is the most common germ cell tumour in infants and children, with a majority of them arising in the gonads. Rare cases of extra – gonadal germ cell tumours have been described in the literature. We are presenting here, a case of a yolk sac tumour of the cryptorchid testis in a 2 year old child, who initially presented with a mass in the left lobe of the liver, with huge ascites and which posed diagnostic difficulties. The mass was diagnosed as hepatoblastoma on Computed Tomography (CT). Subsequently, CT guided Fine Needle Aspiration Cytology (FNAC) of the liver mass showed the features of a yolk sac tumour. The raised serum Alfa Foetoprotein (AFP) levels corroborated with the cytological diagnosis.

Barman, Dilip Chandra; Halder, Aniket; Bhattacharya, Sumanta; Mandal, Krishnendu; Mallick, Sanjay Kumar

2013-01-01

103

An anatomical study of the respiratory air sacs in ostriches.  

PubMed

An accurate description of the number, location and relative position of the air sacs and their diverticula in the ostrich is essential for a better understanding of the pathogenesis of air sacculitis in this bird. The air sacs were studied in ten ostriches of varying ages by latex or silicone casting of the respiratory tract and dissection. Results revealed that the air sacs of the ostrich conform to the general pattern in birds. Cervical, lateral and medial clavicular, cranial and caudal thoracic, and abdominal air sacs are present. The left and right medial clavicular air sacs fuse with each other ventrally to the trachea to form a single, median compartment. A unique, large gastric diverticulum which covers the caudal aspects of the proventriculus and gizzard originates from the median compartment of the clavicular air sac. The lateral clavicular air sacs and their diverticula are similar to those of other bird species, with the exception that humeral diverticula are absent. Both abdominal air sacs are relatively small, with the left sac being the larger. Perirenal and femoral diverticula, similar to those found in other bird species, are present. However, the entire femur is aerated by the femoral diverticulum which also forms a large, subcutaneous division caudally and caudo-laterally to the femur. The presence of this subcutaneous part has practical implications for injury and intramuscular injections. The number and location of ostia connecting the air sacs to the bronchial tree are generally similar to those reported in other bird species. PMID:10689704

Bezuidenhout, A J; Groenewald, H B; Soley, J T

1999-12-01

104

Strain-rate effects on mechanical properties for SAC387 and SAC105-Y solder  

Microsoft Academic Search

In this paper, solder alloy of Sn-3.8Ag-0.7Cu (SAC387) and Sn-1.0Ag-0.5Cu-Y (SAC105-Y), where Y is a small addition of a fourth element, were tested at room temperature to study the strain-rate-dependent elastic modulus and yield strength of the solder. Nano-indentation tests were conducted at various strain rates from 10-3 to 101 1\\/s by using the continuous stiffness measurement (CSM) technique. Microstructures

Luhua Xu; Kok Ee Tan; John H. L. Pang

2008-01-01

105

Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors  

ClinicalTrials.gov

Childhood Embryonal Tumor; Childhood Extracranial Germ Cell Tumor; Childhood Extragonadal Germ Cell Tumor; Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Childhood Teratoma; Ovarian Embryonal Carcinoma; Ovarian Yolk Sac Tumor; Stage II Malignant Testicular Germ Cell Tumor; Stage IIA Ovarian Germ Cell Tumor; Stage IIB Ovarian Germ Cell Tumor; Stage IIC Ovarian Germ Cell Tumor; Stage III Malignant Testicular Germ Cell Tumor; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIC Ovarian Germ Cell Tumor; Testicular Choriocarcinoma and Yolk Sac Tumor; Testicular Embryonal Carcinoma

2013-06-10

106

Tumor  

MedlinePLUS

Mass; Neoplasm ... removed for cosmetic reasons. Benign tumors of the brain may be removed because of their location or harmful effect on the surrounding normal brain tissue. If a tumor is cancer, possible treatments ...

107

Periocular dirofilariasis mimicking lacrimal sac mucocoele.  

PubMed

Abstract Dirofilariasis is a zoonotic infection caused by filarial nematodes belonging to the genus dirofilariae. Dirofilaria is commonly seen in dogs, cats and other carnivorous animals world wide. Mosquitoes of the genus Culex, Anopheles and Aedes are the vectors and the humans are either incidental hosts or dead-end hosts. It affects lungs, liver and other visceral organs. Ocular involvement is rarely been reported. We present a case of 51-year-old female from Kerala, the southern State of India presented with a mass mimicking lacrimal sac mucocoele whose biopsy is proved to be dirofilariasis. PMID:23895409

Pauly, Marian; Biswas, Jyotirmay; Hussain, Rameez N; Anantharaman, Giridhar

2013-07-29

108

First Argentine scientific satellite - SAC I  

NASA Astrophysics Data System (ADS)

Plans for SAC I, an Argentine scientific satellite to be launched at the next solar maximum to an orbit with altitude 500 km, period 95 min, and inclination 97 deg to study high-energy-particle interactions in the solar atmosphere, are summarized. The history and organization of the project are traced; the scientific goals and instrumentation are characterized; and the proposed spacecraft configurations is illustrated with drawings. Lists of equipment parameters are provided, and the project status (at the end of the definition and feasibility studies) is discussed.

Sanchez Pena, M.; Machado, M. E.

1984-10-01

109

Properties of RR Tel using SAC method  

NASA Astrophysics Data System (ADS)

The SAC method is a semi-empirical method of analysing the emission lines of ions with a complicated spectrum like Fe+. In a common work with Mrs. D. Kotnik-Karuza, we applied the method to the symbiotic RR Tel. We were able to obtain information on the excitation temperature, non-LTE effects, the radius of the line formation region and the column density. All these results support formation of the emission lines in the wind of the cool giant component. It was possible to determine a minimum mass loss rate for this star.

Friedjung, Michael; Kotnik-Karuza, D.; Selvelli, P. L.

2001-05-01

110

Intraoperative Sac Pressure Measurement During Endovascular Abdominal Aortic Aneurysm Repair  

Microsoft Academic Search

Purpose  Intraoperative sac pressure was measured during endovascular abdominal aortic aneurysm repair (EVAR) to evaluate the clinical\\u000a significance of sac pressure measurement.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  A microcatheter was placed in an aneurysm sac from the contralateral femoral artery, and sac pressure was measured during\\u000a EVAR procedures in 47 patients. Aortic blood pressure was measured as a control by a catheter from the left brachial

Hiroyuki Ishibashi; Tsuneo Ishiguchi; Takashi Ohta; Ikuo Sugimoto; Hirohide Iwata; Tetsuya Yamada; Masao Tadakoshi; Noriyuki Hida; Yuki Orimoto; Seiji Kamei

2010-01-01

111

Endolymphatic sac tumour. A case report.  

PubMed

We present the case of a patient with an endolymphatic sac tumour (ELST). This rare tumour entity has only recently been defined and despite a well characterized clinical appearance misdiagnosis as jugular paraganglioma is frequent. A 68-year-old woman was admitted to our Neurosurgical Department with a mass lesion extending from the left temporal bone to the cerebello-pontine angle (CPA). Radiological features were high vascularization, contrast enhancement and destruction of the os petrosum. After preoperative angiographic embolization the tumour was removed in two surgical interventions, first via a lateral suboccipital approach and second by petrosectomy. The lesion proved to be a typical endolymphatic sac tumour by a synopsis of histological, radiological and clinical features. ELST should be taken into consideration in patients with mass lesions in the cerebellopontine angle destroying the petrous bone and resembling paraganglioma. Since slow growth rate and lack of metastases are particular features of ELST, complete resection of the tumour results in long survival times without adjuvant chemo- or radiotherapy. PMID:11731743

Nestler, U; Winking, M; Huegens-Penzel, M; Kuchelmeister, K; Boeker, D K

2001-09-01

112

DNA Binding and Bending by Sac7d is Stepwise.  

PubMed

Which came first? Using thermodynamic cycles constructed from experimental measures of the binding free energy and free energy simulations, we have shown that binding of Sulfolobus acidocaldarius protein Sac7d to DNA occurs before DNA bending, thus indicating that a conformational selection mechanism is unlikely to be operative in Sac7d binding. PMID:23853062

Spiriti, Justin; van der Vaart, Arjan

2013-07-12

113

Loss of air sacs improved hominin speech abilities.  

PubMed

In this paper, the acoustic-perceptual effects of air sacs are investigated. Using an adaptive hearing experiment, it is shown that air sacs reduce the perceptual effect of vowel-like articulations. Air sacs are a feature of the vocal tract of all great apes, except humans. Because the presence or absence of air sacs is correlated with the anatomy of the hyoid bone, a probable minimum and maximum date of the loss of air sacs can be estimated from fossil hyoid bones. Australopithecus afarensis still had air sacs about 3.3 Ma, while Homo heidelbergensis, some 600 000 years ago and Homo neandethalensis some 60 000 years ago, did no longer. The reduced distinctiveness of articulations produced with an air sac is in line with the hypothesis that air sacs were selected against because of the evolution of complex vocal communication. This relation between complex vocal communication and fossil evidence may help to get a firmer estimate of when speech first evolved. PMID:22078314

de Boer, Bart

2011-11-10

114

Vertebral pneumaticity, air sacs, and the physiology of sauropod dinosaurs  

Microsoft Academic Search

The vertebrae of sauropod dinosaurs are characterized by complex architecture involv- ing laminae, fossae, and internal chambers of various shapes and sizes. These structures are inter- preted as osteological correlates of a system of air sacs and pneumatic diverticula similar to that of birds. In extant birds, diverticula of the cervical air sacs pneumatize the cervical and anterior thoracic vertebrae.

Mathew J. Wedel

2003-01-01

115

83. SAC control center administration section and underground structure elevations ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

83. SAC control center administration section and underground structure elevations and sections, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

116

82. SAC control center underground structure sections and unit substation ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

82. SAC control center underground structure sections and unit sub-station details, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

117

86. SAC control center administration section underground structure and theater ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

86. SAC control center administration section underground structure and theater sections and elevations, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

118

Adrenergic innervation of the human endolymphatic sac.  

PubMed

Adrenergic innervation of the human endolymphatic sac (ES) has not been verified previously. To investigate this question a sensitive histofluorescence method for visualization of catecholamines and serotonin, using a solution composed of sucrose-potassium phosphate-glyoxylic acid (SPG) in cryostat sections, was employed. Three human ES specimens were obtained during surgery for acoustic neuroma. Distinct fluorescence in the subepithelial tissue, indicating the presence of monoaminergic neurones and their axonal varicosities, was observed. SPG-positive terminal nerve fibres around small ES capillaries and subendothelially were also seen. Like the effects of sympathetic stimulation elsewhere in the human body, the ES might respond to such stimulation with, for example, vasoconstriction and increased transepithelial water transport. Since the ES is thought to be responsible for maintaining inner ear fluid homeostasis, adrenergic influence could be important for it to function properly. PMID:7825435

Birgerson, L; Friberg, U; Rask-Andersen, H; Widenfalk, B

1994-09-01

119

Physicochemical Properties of Sn-Zn and SAC + Bi Alloys  

NASA Astrophysics Data System (ADS)

Applying the discharge crucible (DC) method, the viscosity, density, and surface tension were determined for Sn-9Zn and Sn-2.92Ag-0.4Cu-3.07Bi (SAC + Bi) alloys. For comparison, the dilatometric, maximum bubble pressure, and capillary flow methods were used for measurements of these same physicochemical properties for the Sn-2.92Ag-0.4Cu-3.07Bi (SAC + Bi) alloy. The measurements were performed for Sn-9Zn and SAC + Bi alloys in the temperature range from 513 K to 723 K and 530 K to 1180 K, respectively. The experimental data obtained show that addition of Bi to SAC increases the density and decreases the surface tension and viscosity in comparison with SAC solder. Additionally it was found that the properties studied by different methods (maximum bubble pressure, dilatometric, capillary flow, and discharge crucible) were almost identical.

Gancarz, Tomasz; Pstru?, Janusz; G?sior, W?adys?aw; Henein, Hani

2013-02-01

120

Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors  

ClinicalTrials.gov

Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Unspecified Childhood Solid Tumor, Protocol Specific

2013-05-01

121

Infantile and adult testicular germ cell tumors  

Microsoft Academic Search

Most adult testicular germ cell tumors have a characteristic chromosomal abnormality that is an isochromosome 12p [i(12p)]. Furthermore, these tumors are characterized by a chromosome number in the triploid range and gains and losses of (parts of) specific chromosomes. Cytogenetic investigation of three cases of infantile testicular germ cell tumors, all diagnosed as yolk sac tumors, revealed highly abnormal karyotypes.

Jannie van Echten; Albertus Timmer; Anneke Y van der Veen; Willemina M Molenaar; Bauke de Jong

2002-01-01

122

Malignant mediastinal germ cell tumor with pure hepatoid differentiation.  

PubMed

We describe a germ cell tumor of anterior mediastinal origin, with pure hepatoid differentiation and elevated serum AFP in a 41-year-old man. This is the first report of such a neoplasm analyzed by conventional stains and immunohistochemistry. Hepatocellular differentiation was proved by immunoreactivity with HepPar-1 and alpha-fetoproein (AFP), membranous expression of carcinoembryonic antigen (CEA-poly) in a canalicuar pattern, and focal expression of cytokeratin 19 in abortive ductular structures. Our investigation shows that mediastinal germ cell tumors with hepatoid components typically arise in middle-aged men; they are of pure hepatoid differentiation, as demonstrated here, or exclusively associated with yolk sac structures. PMID:12530574

Theuerkauf, Ingo; Axmann, Cristoph; Wolff, Martin; Tschubel, Klaus; Fischer, Hans-Peter

2002-01-01

123

Hematopoiesis in the yolk sac: more than meets the eye.  

PubMed

The first blood cells observed in the embryo are large nucleated erythroblasts generated in blood islands of the extraembryonic yolk sac. These unique red cells have been termed primitive because of their resemblance to nucleated erythroblasts of nonmammalian species. It is now widely assumed that hematopoiesis in the yolk sac is "primitive" and that "definitive" hematopoiesis has its origins in the aorta/gonad/mesonephros (AGM) region. Recent studies of yolk sac hematopoiesis have challenged several aspects of this paradigm. First, primitive erythropoiesis in mammals shares many features with definitive erythropoiesis, including progressive erythroblast maturation leading to the circulation of enucleated erythrocytes. Second, the emergence of primitive erythroid progenitors in the yolk sac prior to somitogenesis may be associated with the macrophage and megakaryocyte lineages, raising the possibility that "primitive" hematopoiesis may be multilineage in nature. Third, a second wave of hematopoietic progenitors emerge from the yolk sac during early somitogenesis that consists of multiple myeloid lineages that are temporally and spatially associated with definitive erythroid progenitors. These "definitive" hematopoietic progenitors expand in numbers in the yolk sac and are thought to seed the fetal liver and generate the first definitive blood cells that rapidly emerge from the liver. Recent findings support a model of hematopoietic ontogeny in which the conceptus' first maturing blood cells and committed progenitors are provided by the yolk sac, allowing survival until AGM-derived hematopoietic stem cells can emerge, seed the liver and differentiate into mature blood cells. PMID:16140150

McGrath, Kathleen E; Palis, James

2005-09-01

124

Total laparoscopic hysterectomy with obliterated anterior cul-de-sac  

PubMed Central

Endometriosis may in severe cases lead to obliteration of the anterior and/or posterior cul-de-sacs in the female pelvis. The anterior cul-de-sac is generally less commonly affected. This type of cases usually presents a challenge for the operating surgeon, whether via open route or through laparoscopy. In this paper, we present an illustrative case and explain our technique for dealing with a scarred and totally obliterated anterior cul-de-sac because of endometriosis during total laparoscopic hysterectomy.

Walid, M. Sami; Heaton, Richard L.

2010-01-01

125

[Surgery for benign schwannoma arising at the thoracic apex].  

PubMed

It is difficult to determine surgical approaches for treating a tumor arising at the thoracic outlet. Here we report a case of benign schwannoma arising at the thoracic apex, in which both pleural and cervical approaches were adopted. Chest radiographs of a 58-year-old male at the medical checkup in 2009 showed a tumor shadow in the right apical region that was increasing since 2003. He had no symptoms. Computed tomography(CT)and magnetic resonance imaging (MRI) showed a 35-mm tumor, which had a smooth surface and was suspected as a neurogenic tumor arising at the right thoracic outlet. Surgery for this tumor was performed by the thoracoscopic approach with a mini thoracotomy through the 3 intercostal space 1. The tumor was suspected to arise from the brachial plexus, and was not able to be enucleated. Then we made a cervical incision and the tumor was resected safely using a pleural approach together with a cervical approach. The pathological finding was benign shwannoma. Mild ulnar nerve palsy was observed in the patient after surgery, which gradually improved within 3 years. PMID:24105120

Takata, Masahiko; Miyamoto, Yoshifumi

2013-10-01

126

A Case of Recurrent Schneiderian Papilloma of the Lacrimal Sac Invading the Nasal Cavity  

PubMed Central

A 44-year-old man presented with a history of chronic epiphora, discharge from the right eye, and a palpable mass in the medial canthal area. Irrigation of the lacrimal system revealed bloody discharge. Orbital magnetic resonance imaging (MRI) showed a well-defined heterogeneous enhanced mass filling the lacrimal sac and upper nasolacrimal duct (NLD). A wide excision and surgical biopsy were performed. Histopathology showed the tumor to be an exophytic Schneiderian papilloma with moderate to severe dysplasia. Three months later, the mass was found to be invading the nasal cavity through the NLD. Endoscopic histopathological evaluation confirmed that it was identical to the originally identified papilloma.

Jang, Ji Hye; Choe, Mi Sun

2009-01-01

127

A comparison of the creep behaviour of joint-scale SAC105 and SAC305 solder samples under shear conditions  

Microsoft Academic Search

This study compares the creep behavior of joint-scale Sn1.0Ag0.5Cu (SAC105) and Sn3.0Ag0.5Cu (SAC305) solder samples under shear loading. The basis of the comparison is experimentally derived Anand viscoplastic constitutive models for the alloys. A series of monotonic constant shear stress and constant shear strain rate tests was conducted at temperatures of 20°C, 50°C, 75°C and 100°C for SAC105 in order

Cillian Burke; Jeff Punch

2012-01-01

128

79. Sac digital network (Sacdin), summary fault indicator at top, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

79. Sac digital network (Sacdin), summary fault indicator at top, south side - Ellsworth Air Force Base, Delta Flight, Launch Control Facility, County Road CS23A, North of Exit 127, Interior, Jackson County, SD

129

Qualitative Analysis of Supervision in SAC Minuteman ICBM Maintenance.  

National Technical Information Service (NTIS)

Supervision is a large part of managing the SAC Minuteman ICBM maintenance production effort by providing important factors which lead to job satisfaction and motivation in subordinates. The people who manage, supervise, and perform missile maintenance ar...

S. W. Fancher

1983-01-01

130

Acute abdomen secondary to rare yolk sac tumour  

Microsoft Academic Search

A 36-year-old woman presented unwell, with abdominal pain. A pelvic mass was found and being investigated but when she deteriorated\\u000a and became peritonitic. An emergency laparotomy was performed and she required a pelvic clearance for a Stage IIB ovarian\\u000a tumour, later confirmed as a yolk sac tumour. Accurate staging and tumour-reductive surgery strongly affects the prognosis\\u000a of yolk sac tumours.

Hooman Soleymani Majd; Sally Ann Turner; Kiyoshi Choji; Khin Lwin; Christopher B-Lynch

2009-01-01

131

The craniofacial air sac systetn of Mesozoic birds (Aves)  

Microsoft Academic Search

Birds are characterized by pneumatization of their skeletons by epithelial diverticula from larger, air-filled cavities. The diverticula-or 'air sacs'-that invade the postcranium result from outgrowths of the lungs; postcranial pneumaticity has been very well studied. Much more poorly understood are the air sacs that pneumatize the skull. Study of craniofacial pneumaticity in modern birds (Neornithes) indicates the presence of two

LAWRENCE M. WITMER

1990-01-01

132

Brain Tumors Facts and Statistics  

MedlinePLUS

... making them the most common primary brain tumor. Gliomas, a broad term which includes all tumors arising ... all primary brain tumors, and 54% of all gliomas. Astrocytomas represent 7% of all primary brain tumors. ...

133

Giant prosthetic reinforcement of the visceral sac.  

PubMed

One hundred and seventy-nine patients with 237 hernias of the groin who were at high risk for recurrence after classic hernioplasty were operated upon; the procedure of giant prosthetic reinforcement of the visceral sac (GPRVS) was used. The patients in this series had predominantly recurrent and re-recurrent hernias. However, a few were obese with bilateral primary direct hernias and some had associated connective tissue disorders, such as Marfan and Ehlers-Danlos syndromes. GPRVS eliminates hernias of the groin by rendering the peritoneum inextensible by placing, in the preperitoneal space, a large prosthesis that extends far beyond the borders of the myopectineal orifice. The myopectineal orifice is the weak spot at which all hernias of the groin begin and is bounded by the rectus, oblique abdominal and iliopsoas muscles and the pectin of the pubis. In bilateral GPRVS, the peritoneum of both groins is reinforced with a single prosthesis inserted in the preperitoneal space through the midline. In unilateral GPRVS, the mesh envelops the peritoneum of a single groin. This simplifies the operation and makes it suitable for surgical centers that perform outpatient operations. The prosthesis with the best physical characteristics for GPRVS is Mersilene (polyester fiber). Unsutured prostheses of polypropylene and Teflon (polytetrafluoroethylene) may not adhere at the far edges, leading to a failure and recurrence. The over-all recurrence rate in this series of problem hernias was 3.7 per cent, which is extremely good. However, the rate becomes outstanding if recurrences resulting from meshes unsuitable for GPRVS are excluded. PMID:2814751

Wantz, G E

1989-11-01

134

Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis  

PubMed Central

The Drosophila dorsal Air Sac Primordium (ASP) is a tracheal tube that grows toward Branchless FGF-expressing cells in the wing imaginal disc. We show that the ASP arises from a tracheal branch that invades the basal lamina of the disc to juxtapose directly with disc cells. We examined the role of matrix metalloproteases (Mmps), and found that reducing Mmp2 activity perturbed disc-trachea association, altered peritracheal distributions of Collagen IV and Perlecan, misregulated ASP growth, and abrogated development of the dorsal air sacs. Whereas the function of the membrane-tethered Mmp2 in the ASP is non-cell autonomous we find that it may have distinct tissue-specific roles in the ASP and disc. These findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix.

Guha, Arjun; Lin, Li; Kornberg, Thomas B.

2009-01-01

135

Sarcomatoid thymic carcinoma arising in metaplastic thymoma: a case report.  

PubMed

Metaplastic thymoma is an extremely rare tumor. To date, only 17 cases of metaplastic thymoma have been reported. To the best of the authors' knowledge, this is the second reported case of a sarcomatoid carcinoma arising in metaplastic thymoma; the carcinoma in this case is larger than that in the previous case. A 63-year-old woman with cough and asthenia for 2 weeks was admitted to the hospital. Computed tomography (CT) revealed a giant mass on the right side of the front mediastinum medium. The mediastinal tumor was excised, and additional pathological examinations, immunohistochemical tests, and electron-microscopic tests were performed. The tumor was diagnosed as a sarcomatoid carcinoma arising in metaplastic thymoma. Here, the authors discuss the clinical pathology of the sarcomatoid carcinoma arising in metaplastic thymoma and describe the biological behaviors with respect to the pathological features. PMID:20034984

Lu, Hong-sheng; Gan, Mei-fu; Zhou, Tao; Wang, Shuang-zhu

2009-12-24

136

Intraoperative Sac Pressure Measurement During Endovascular Abdominal Aortic Aneurysm Repair  

SciTech Connect

PurposeIntraoperative sac pressure was measured during endovascular abdominal aortic aneurysm repair (EVAR) to evaluate the clinical significance of sac pressure measurement.MethodsA microcatheter was placed in an aneurysm sac from the contralateral femoral artery, and sac pressure was measured during EVAR procedures in 47 patients. Aortic blood pressure was measured as a control by a catheter from the left brachial artery.ResultsThe systolic sac pressure index (SPI) was 0.87 {+-} 0.10 after main-body deployment, 0.63 {+-} 0.12 after leg deployment (P < 0.01), and 0.56 {+-} 0.12 after completion of the procedure (P < 0.01). Pulse pressure was 55 {+-} 21 mmHg, 23 {+-} 15 mmHg (P < 0.01), and 16 {+-} 12 mmHg (P < 0.01), respectively. SPI showed no significant differences between the Zenith and Excluder stent grafts (0.56 {+-} 0.13 vs. 0.54 {+-} 0.10, NS). Type I endoleak was found in seven patients (15%), and the SPI decreased from 0.62 {+-} 0.10 to 0.55 {+-} 0.10 (P = 0.10) after fixing procedures. Type II endoleak was found in 12 patients (26%) by completion angiography. The SPI showed no difference between type II endoleak positive and negative (0.58 {+-} 0.12 vs. 0.55 {+-} 0.12, NS). There were no significant differences between the final SPI of abdominal aortic aneurysms in which the diameter decreased in the follow-up and that of abdominal aortic aneurysms in which the diameter did not change (0.53 {+-} 0.12 vs. 0.57 {+-} 0.12, NS).ConclusionsSac pressure measurement was useful for instant hemodynamic evaluation of the EVAR procedure, especially in type I endoleaks. However, on the basis of this small study, the SPI cannot be used to reliably predict sac growth or regression.

Ishibashi, Hiroyuki, E-mail: ishibash@aichi-med-u.ac.j [Aichi Medical University Hospital, Department of Vascular Surgery (Japan); Ishiguchi, Tsuneo [Aichi Medical University Hospital, Department of Radiology (Japan); Ohta, Takashi; Sugimoto, Ikuo; Iwata, Hirohide; Yamada, Tetsuya; Tadakoshi, Masao; Hida, Noriyuki; Orimoto, Yuki [Aichi Medical University Hospital, Department of Vascular Surgery (Japan); Kamei, Seiji [Aichi Medical University Hospital, Department of Radiology (Japan)

2010-10-15

137

The short-circuited everted sac of rat colon mucosa.  

PubMed

A short-circuited preparation of everted rat colon sacs is described. The serosal current electrode is a AgAgCl wire. A cylindrical agar bridge or AgAgCl electrode may be employed on the mucosal side. Effects of Ag+ ions liberated from the electrodes on ion transport could not be demonstrated. Fluid and sodium are absorbed ad bicarbonate secreted. Potassium and chloride movements are not significantly different form zero. The preparation remains stable for at least 2 h. Sodium absorption is diminished by 50% and bicarbonate secretion abolished in the absence of glucose. In principle, similar ion transport properties were found as in Ussing-chamber preparations. The advantage of the everted sac is the capability of measuring net transport of fluid and electrolytes simultaneously and directly because of the large surface/inner volume ratio of the sac. PMID:7232872

Goerg, K J; Wanitschke, R; Soergel, K H; Wood, C M; Nell, G

1981-01-01

138

SAC-C mission, an example of international cooperation  

NASA Astrophysics Data System (ADS)

The SAC-C is an international Earth observing satellite mission developed as a partnership between CONAE and NASA, with additional support in instrumentation and satellite development from the Danish DSRI, the Italian ASI, the French CNES and the Brazilian INPE. The SAC-C satellite was successfully launched by a Delta II rocket on November 21, 2000, from Vandenberg AFB, California, USA. The purpose of this mission is to carry out observations which bear interest both for the USA and Argentina, thus contributing effectively to NASA's Earth Science Program and to CONAE's National Space Program. The inclusion of SAC-C in the “morning constellation”, jointly with NASA satellites Landsat 7, EO 1 and Terra, is another example of an important international cooperation which strengthens the output of any single mission.

Colomb, F. R.; Alonso, C.; Hofmann, C.; Nollmann, I.

2004-01-01

139

Extragonadal germ cell tumors: a fine-needle aspiration biopsy study.  

PubMed

Germ cell tumors (GCT) are neoplasms that originate predominately in the ovary and testis. Tumors of germ cell origin only very uncommonly arise in extragonadal sites. We have diagnosed ten primary malignant extragonadal GCT arising in the mediastinum, retroperitoneum, liver, and sacrococcygeal region by fine-needle aspiration biopsy (FNAB). Patient ages ranged from 1 to 54 years; the majority were males. Our series included three seminomas, three yolk sac tumors (YST), one choriocarcinoma, one embryonal carcinoma, and two mixed, poorly differentiated GCT. In aspirates, seminomatous elements are dissociated with uniform mononucleate cells having large vesicular nuclei and prominent nucleoli. A tigroid background is produced with Diff-Quik-stained smears. YST yields cohesive clusters of cells with large nuclei, vacuolated cytoplasm, and extracellular hyaline matrix (spheres or hyaline globules). Giant multinucleate tumor cells are seen in choriocarcinoma. Embryonal carcinoma yields cellular smears of hyperchromatic cells with scant cytoplasm arranged predominantly in glandular or papillary formations. Ultrastructural (four cases) and immunocytochemical (seven cases) studies of aspirated material corroborated our cytologic interpretations. Aneuploid tumor cells were found by flow cytometry in aspirated material from a YST. Subsequent histologic examinations were performed on eight, and all were confirmatory. Although extragonadal GCT are relatively uncommon, they need to be considered in FNAB material from midline mass lesions. Ancillary studies were useful in confirming their diagnosis. PMID:7621717

Collins, K A; Geisinger, K R; Wakely, P E; Olympio, G; Silverman, J F

1995-05-01

140

Endoscopic examination of snakes by access through an air sac  

Microsoft Academic Search

Sixteen boa constrictors (Boa constrictor), three royal pythons (Python regius) and 15 Burmese pythons (Python molurus bivittatus) were examined endoscopically by access through the air sac. The snakes were immobilised in a ventral position using a half-open anaesthetic system with assisted ventilation and a mixture of isoflurane and oxygen. The rigid endoscope was introduced percutaneously and the internal structure of

V. Jekl; Z. Knotek

2006-01-01

141

Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis  

Microsoft Academic Search

The enucleated definitive erythrocytes of mammals are unique in the animal king- dom. The observation that yolk sac- derived primitive erythroid cells in mam- mals circulate as nucleated cells has led to the conjecture that they are related to the red cells of fish, amphibians, and birds that remain nucleated throughout their life span. In mice, primitive red cells express

Paul D. Kingsley; Jeffrey Malik; Katherine A. Fantauzzo; James Palis

2004-01-01

142

Structure of the Compensation Sac in two Ascophoran Bryozoans  

Microsoft Academic Search

Harmer established two groups of ascophoran bryozoans on structural differences in the compensation sac (ascus) and the frontal wall, although both he and Silen believed that the frontal wall of both groups is deposited within a simple ventral fold of 'frontal membrane'. Such a fold would be expected to secrete a wall consisting of mineral and\\/or organic successions disposed symmetrically

R. Tavener-Smith; A. Williams

1970-01-01

143

Midline nasal dermoids presenting like discharging lacrimal sac mucocoeles  

Microsoft Academic Search

Two cases of midline intranasal dermoid cysts presenting like discharging lacrimal sac mucocoeles in children are described. The diagnosis of this rare condition is suggested by the presence of midline nasal cutaneous dimples, although these may be associated with isolated anomalies such as nasal dermoid cyst, encephalocoele or glioma.

Irene Whelehan; Geoffrey E Rose

1995-01-01

144

Characterization of yolk sac proteins of Bos indicus cattle embryos.  

PubMed

The yolk sac is an embryonic membrane that is essential for the embryo's initial survival in many mammals. It also plays an important role in the production of proteins necessary for development. We studied proteins of the yolk sac in bovine embryos at up to 40 days of gestation. We examined the yolk sac of 17 bovine embryos at different gestational periods, measuring ?-fetoprotein, ?-1-antitrypsin, and transferrin. This experiment was carried out by Western blot technique, associated with electrophoresis on a 6% sodium dodecyl sulfate polyacrylamide gel. Mouse monoclonal antibody anti-human-?-fetoprotein, mouse antibody anti-human-transferrin and rabbit polyclonal anti-human-?-1-antitrypsin were used as primary antibodies, and conjugated peroxidase as a secondary antibody. We detected the three proteins in some of the yolk sac samples; however, the bands in some specimens (samples) were weak, maybe a result of poor antigen-antibody reaction, since the antibodies used in this study were not specific to bovine proteins. The fact that weak bands appeared might be due to a weak cross-reaction. PMID:23212331

Matsumoto, F S; Oliveira, V C; Mançanares, C A F; Ambrosio, C E; Miglino, M A

2012-11-14

145

45. SAC conference room 2A8, second floor, Dwing, building 500, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. SAC conference room 2A8, second floor, D-wing, building 500, looking southeast - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

146

SAC-C mission, an example of international cooperation  

NASA Astrophysics Data System (ADS)

In comp liance with the objectives established in the National Space Program, Argentina in Space 1997-2008 ((Plan Espacial Nacional, Argentina en el Espacio 1997-2008), the National Commission on Space Activities (Comisión Nacional de Actividades Espaciales - CONAE) undertook the design, construction, and launching of the SAC-C satellite in close collaboration with NASA. The purpose of this Mission is to carry out observations of interest both for the USA and Argentina, thus contributing effectively to NASA's Earth Science Program and to CONAE's National Space Program. The SAC-C is an international Earth observing satellite mission conceived as a partnership between CONAE and NASA, with additional support in instrumentation and satellite development from the Danish DSRI, the Italian ASI, the French CNES and the Brazilian INPE. A Delta II rocket successfully launched it on November 21st, 2000, from Vandenberg AFB, California, USA. Ten instruments on board the SAC-C perform different studies related to the ground and sea ecosystems, the atmosphere and the geomagnetic field. There are also technological experiments for determination of the satellite attitude and velocity as well as for the studies of the influence of space radiation on advanced electronic components . The inclusion of SAC-C in the AM Constellation, jointly with NASA satellites Landsat 7, EO 1 and Terra, is another example of important international cooperation which synergies the output of any single Mission. The Constellation has been working since March 2001 as a single mission and several cooperative activities have been undertaken including several jointly sponsored technical workshops and collaborative spacecraft navigation experiments. A flight campaign of the NASA AVIRIS instrument was performed in Argentine during January and February 2001, for calibration of SAC-C and EO 1 cameras and the development of joint scientific works. In Cordoba Space Center a jointly operated ground GPS reference site was installed and three Aeronet stations are working in Argentine as part of the world net.

Colomb, F.; Alonso, C.; Hofmann, C.; Nollmann, I.

147

Ultrastructure of the Developing and Fertilized Embryo Sac of Amaranthus hypochondriacus L  

Microsoft Academic Search

Amaranthus hypochondriacus embryo sac development was investigated before and after fertilization. During the early stages of development, the young embryo sac displays three antipodal cells at the chalazal pole that degenerate very early in the maturation process, before the synergids and egg cell are completely differentiated. The mature embryo sac is composed only of the female germ unit. The synergid

SÍLVIA COIMBRA; ROBERTO SALEMA

1999-01-01

148

Ultrastructure of the Developing and Fertilized Embryo Sac of Amaranthus hypochondriacus L  

Microsoft Academic Search

Amaranthus hypochondriacus embryo sac development was investigated before and after fertilization. During the early stages of development, the young embryo sac displays three antipodal cells at the chalazal pole that degenerate very early in the maturation process, before the synergids and egg cell are completely dierentiated. The mature embryo sac is composed only of the female germ unit. The synergid

C OIMBRA; R OBERTO S ALEMA

149

p63 expression in sclerosing mucoepidermoid carcinomas with eosinophilia arising in the thyroid  

Microsoft Academic Search

Primary sclerosing mucoepidermoid carcinomas with eosinophilia (SMECE) of the thyroid gland are rare tumors that can present diagnostic difficulties to the pathologist due to the unusual histologic features. Furthermore, the etiology of these tumors has been debated in the literature, with some authors believing that the tumors arise from remnants of the ultimobranchial body (UBB, solid cell nests) and others

Jennifer L Hunt; Virginia A LiVolsi; E Leon Barnes

2004-01-01

150

Teratogenic effects of amniotic sac puncture: a mouse model.  

PubMed Central

The possibility of an association between chorionic villus sampling (cvs) and limb abnormalities has prompted a review of the relevant experimental data. Although a vascular aetiology is favoured by many at present, the possibility exists that a proportion of cases may be caused by oligohydramnios secondary to inadvertent amniotic sac puncture. A mouse model of amniotic puncture syndrome has been developed to study the craniofacial and limb abnormalities produced by this procedure. Pregnant mice were anaesthetised and a laparotomy performed. One uterine horn was exteriorised, and the amniotic sacs punctured through the wall of the uterus with either a 21 gauge or a 25 gauge needle. The conceptuses in the contralateral uterine horn acted as controls. The mice were all killed on d 19 of pregnancy (day of finding a vaginal plug = d 1 of pregnancy) by cervical dislocation, and the morphological features of the embryos examined in detail. In a preliminary study, amniotic sac puncture was carried out on d 12, 13, 14, 15 or 16 of pregnancy, with either a 21 or a 25 gauge needle. Since the highest rates of palatal defects and limb deformities were observed following amniotic sac puncture using a 21 gauge needle, when this procedure was carried out on either d 13 or 14 of pregnancy, the main study was undertaken using a 21 gauge needle on these two days of pregnancy. Of 102 embryos in which amniotic sac puncture was carried out on d 13, 53% survived to d 19. Of the latter, 35% had a cleft palate, 61% had one or more morphologically abnormal limbs, and 43% had an abnormal tail. When amniotic sac puncture was carried out on d 14 of pregnancy, of 83 embryos subjected to this procedure, 81% survived to d 19. Of the latter, 27% had a cleft palate, 39% had one or more morphologically abnormal limbs, and 19% had an abnormal tail. In the controls, of 86 and 61 embryos isolated respectively from the d 13 and 14 mice, the survival rates were 97 and 90%, respectively. Palatal, limb and tail abnormalities were not observed in the control series. Tentative relationships are drawn between cvs and amniocentesis-associated abnormalities, the Robin sequence and their rodent phenocopies. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4

MacIntyre, D J; Chang, H H; Kaufman, M H

1995-01-01

151

Primary adenocarcinoma of the vagina arising in endocervicosis.  

PubMed

Endocervicosis is a rare condition, being one of the triad of non-neoplastic secondary mullerian lesions. This report describes a primary vaginal adenocarcinoma arising in endocervicosis. Histologic examination showed a mucin-secreting adenocarcinoma admixed with benign mucin-containing endocervical-type glands with a transition from dysplastic glands to obvious adenocarcinoma. There were bilateral groin lymph node metastases at presentation and the tumor recurred locally 9 and 12 months after treatment. This is the second reported case of vaginal endocervicosis and the first documented report of adenocarcinoma arising in endocervicosis at any site. PMID:11603227

McCluggage, W G; Price, J H; Dobbs, S P

2001-10-01

152

Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis  

PubMed Central

Neuropilins (NP1 and NP2) are vascular endothelial growth factor (VEGF) receptors that mediate developmental and tumor angiogenesis. Transgenic mice, in which both NP1 and NP2 were targeted (NP1?/?NP2?/?) died in utero at E8.5. Their yolk sacs were totally avascular. Mice deficient for NP2 but heterozygous for NP1 (NP1+/?NP2?/?) or deficient for NP1 but heterozygous for NP2 (NP1?/?NP2+/?) were also embryonic lethal and survived to E10–E10.5. The E10 yolk sacs and embryos were easier to analyze for vascular phenotype than the fragile poorly formed 8.5 embryos. The vascular phenotypes of these E10 mice were very abnormal. The yolk sacs, although of normal size, lacked the larger collecting vessels and had less dense capillary networks. PECAM staining of yolk sac endothelial cells showed the absence of branching arteries and veins, the absence of a capillary bed, and the presence of large avascular spaces between the blood vessels. The embryos displayed blood vessels heterogeneous in size, large avascular regions in the head and trunk, and blood vessel sprouts that were unconnected. The embryos were about 50% the length of wild-type mice and had multiple hemorrhages. These double NP1/NP2 knockout mice had a more severe abnormal vascular phenotype than either NP1 or NP2 single knockouts. Their abnormal vascular phenotype resembled those of VEGF and VEGFR-2 knockouts. These results suggest that NRPs are early genes in embryonic vessel development and that both NP1 and NP2 are required.

Takashima, Seiji; Kitakaze, Masafumi; Asakura, Masanori; Asanuma, Hiroshi; Sanada, Shoji; Tashiro, Fumi; Niwa, Hitoshi; Miyazaki, Jun-ichi; Hirota, Seiichi; Kitamura, Yukihiko; Kitsukawa, Takashi; Fujisawa, Hajime; Klagsbrun, Michael; Hori, Masatsugu

2002-01-01

153

Development of yolk sac inversion in Galea spixii and Cavia porcellus (Rodentia, Caviidae).  

PubMed

Caviomorph development includes an inverted yolk sac. Since principle processes are not understood, we investigated its differentiation in Galea and re-examined material from the guinea pig. Galea showed the typical caviomorph conditions in blastocyst development and the nature of the definitive yolk sac, formed of the visceral layer that became villous, proliferative, vascularized and attached to the uterus and placenta. In contrast to what was known before, in both species parts of the parietal yolk sac and a yolk sac cavity were temporarily present. Data suggest that early yolk sac development in caviomorphs is more complex than thought before. PMID:22809674

de Oliveira, M F; do Vale, A M; Favaron, P O; Vasconcelos, B G; de Oliveira, G B; Miglino, M A; Mess, A

2012-07-17

154

SAC-C Mission and the Morning Constellation  

NASA Astrophysics Data System (ADS)

SAC-C is an international Earth observing satellite mission conceived as a partnership between CONAE and NASA, but with additional support in instrumentation and satellite development from the Danish DSRI, the Italian ASI, the French CNES and the Brazilian INPE. A Delta II rocket successfully launched it on November 21st, 2000, from Vandenberg AFB, California, USA. SAC-C has been designed primarily to fulfill the requirements of countries with large extension of territory or scarcely populated like Argentina. Its design is a good compromise between resolution and swath width that makes SAC-C an appropriate tool for global and high dynamic phenomena studies. There are ten instruments on board of SAC-C that will perform different studies, the Multispectral Medium Resolution Scanner (MMRS), provided by CONAE, Argentina, will help in the studies about desertification processes evaluation and their evolution in time (i.e., Patagonia, Argentina), to identify and predict agriculture production, to monitor flood areas and to make studies in coastal and fluvial areas. The MMRS will be associated with a High Resolution Technological Camera (HRTC), also provided by CONAE that will permit improvement in the MMRS resolution in the areas where it will be required. A High Sensitivity Technological Camera (HSTC) is also included in the mission. SAC-C also carries instruments to monitor the condition and dynamics of the terrestrial and marine biosphere and environment (GPS OccuLtation and Passive reflection Experiment (GOLPE)) from NASA/JPL. The Magnetic Mapping Payload, (MMP) developed by the Danish Space Research Institute helps to better understand the Earth's magnetic field and related Sun -Earth interactions .Italian Star Tracker (IST) and Italian Navigation Experiment (INES) developed by the Italian Space Agency, constitute a technological payload that will permit testing a fully autonomous system for attitude and orbit determination. Influence of space radiation on advanced components (ICARE), provided by CNES will permit improvement of risk estimation models for radiation effect on last generation integrated circuit technology. . On June 14th, 2000 CONAE and NASA signed an amendment to the Memorandum of Understanding for the SAC-C mission in order that the SAC-C satellite, were included in a constellation - named "Morning Constellation". It is integrated by USA satellites Landsat 7, EO 1, Terra, and Argentine SAC-C that feature on-board instruments from the United States, Argentina, Denmark, Italy, France, and Japan. The four satellite tracks on the Earth's surface are the same, their orbital height being 705 km and their inclination, 98.21 degrees. They cross the Equator at 10:00, 10:01, 10:15, and 10:30 hours, respectively (local time). Satellites comply with the World Wide Reference System. The Constellation has been working since March 2001 as a single mission and several cooperative activities have been undertaken and will be presented in this paper. Several jointly sponsored technical workshops have been held, and also collaborative spacecraft navigation experiments have been made. One of the objectives of the AM Constellation is the collaboration in the case of emergencies, NASA and CONAE agreed to give preference in those situation in the planification of their satellite acquisitions. From all the possible hazardous events, the most important for the country are fire and floods. In relation to fires, CONAE is presently adapting and developing the algorithms for using MODIS data to generate a fire map product. Additionally research on fire detection is carried out using the data from the HSTC camera. In relation to flooding, CONAE works in cooperation to national institutions providing the data and, in some cases, producing flood extent maps. In particular MMRS data is demonstrating to be very effective due to its spectral and radiometric resolutions, and its large swath which is well suited for extended countries like Argentina.

Colomb, F. R.; Alonso, C.; Hofmann, C.; Frulla, L.; Nollmann, I.; Milovich, J.; Kuba, J.; Ares, F.; Kalemkarian, M.

2002-01-01

155

Steatorrhoea in rats with an intestinal cul-de-sac  

Microsoft Academic Search

Steatorrhoea in rats with an intestinal cul-de-sac is mainly due to malabsorption of alimentary fats but faecal lipids of endogenous origin are also increased. Steatorrhoea depends on the site of the blind loop in the small intestine and is mainly caused by bacterial proliferation in the lumen of the gut. The aetiological role of Gram-positive anaerobic microbes, especially Clostridium welchii,

P. P. Hoet; H. Eyssen

1964-01-01

156

Thermal cycling fatigue analysis of SAC387 solder joints  

Microsoft Academic Search

In this study, finite element analysis (FEA) was used to simulate a thermal cycling test result for a PBGA assembly with Sn-3.8Ag-0.7Cu solder joints subject to thermal cycling of -40°C to +125°C. The PBGA assembly was modeled using a 3D-quarter 1\\/8th octant model of the PBGA assembly. Two constitutive models for the SAC387 solder were investigated using the Anand Viscoplastic

Chandra Williams; Kok Ee Tan; John H. L. Pang

2010-01-01

157

SAC HD45677 FeII emission lines analysis  

NASA Astrophysics Data System (ADS)

Aurelie observations of the probably Herbig Ae/Be star HD45677 are analysed using the SAC method applied to the various FeII and CrII emission lines components. A comparison with V380 Ori show that FeII lines are opticaly thinner for the object studied. Consequently HD45677 appears to be less evolved than V380 Ori, probably in the phase where the disk is disappearing.

Muratorio, Gérard; Friedjung, Michael

2001-05-01

158

SAC-B GaAs solar array  

Microsoft Academic Search

This paper describes the electrical and mechanical design of the GaAs solar array of SAC-B, an Argentinian scientific satellite, planned for launch in 1995 into a 550-km circular orbit by Pegasus vehicle. The solar array is made up of four deployable wings, embodying approximately 1000 LPE GaAs solar cells, (30 x 41 sq mm), capable of providing about 215 W

L. Brambilla; A. Caon; R. Contini; G. D'Accolti; E. Rossi; G. Verzeni; C. Flores; F. Paletta; G. Pedrazzoli; M. Grattarola

1993-01-01

159

S-Allylcysteine reduces breast tumor cell adhesion and invasion.  

PubMed

Previous studies show that aqueous garlic extract and its derivatives (e.g. S-allylcysteine [SAC]) prevent carcinogen-induced breast tumorigenesis. However, investigations testing the effect of SAC on later stages of breast tumorigenesis and/or metastasis have produced mixed results. Here we show that SAC significantly reduced anchorage-dependent and -independent growth of MDA-MB-231 breast tumor cells in a dose- and time-dependent fashion, and sub-lethal SAC-treatment altered mammary tumor cell adhesion and invasion through components of the extracellular matrix. We provide evidence to suggest increased expression of E-cadherin and reduced MMP-2 expression and activity are partially responsible for inhibition of mammary tumor cell invasion by SAC. Because E-cadherin and MMP-2 are important in cancer metastasis, these results suggest a link between SAC induction of E-cadherin and reduction of MMP2 activity with the inhibition of cell motility and invasion; thus providing evidence that events leading to breast cancer metastasis are repressed by sub-lethal SAC-treatment. PMID:18190785

Gapter, Leslie A; Yuin, Ong Zhan; Ng, Ka-Yun

2008-01-09

160

Endoscopic examination of snakes by access through an air sac.  

PubMed

Sixteen boa constrictors (Boa constrictor), three royal pythons (Python regius) and 15 Burmese pythons (Python molurus bivittatus) were examined endoscopically by access through the air sac. The snakes were immobilised in a ventral position using a half-open anaesthetic system with assisted ventilation and a mixture of isoflurane and oxygen. The rigid endoscope was introduced percutaneously and the internal structure of the lungs and the air sac, and the shape, size and external surface of the liver were visible in the cranial direction. In the smaller snakes the bifurcation and caudal part of the trachea could be viewed, provided the endoscope was positioned in a retrograde orientation. The caudal orientation of the endoscope made it possible to view the gall bladder and the size, shape and surface of the spleen. In some cases, the pancreas and the surface of the stomach and colon could be monitored. Endoscopy through the air sac also made it possible to check the major veins in the coelom. The snakes were monitored for at least 30 days after the intervention and no changes in their respiratory function or general health were observed. PMID:16565339

Jekl, V; Knotek, Z

2006-03-25

161

Oblique sectional planes of block plastinates eased by Sac Plastination.  

PubMed

To find an oblique cutting plane of a plastinate, e.g. to cut gamma-nails in the femur, the Block Plastination technique was modified. After CT and MRI examination, the specimens were plastinated with the standard resin mixture E6/E12/E600. Instead of using a box to form a block during the casting and curing stage, we embedded the specimen in a sac made of polyester foil. A polymerized wooden block was attached to the specimen. The sac was wrapped with tape to the embedded specimen with the block. This approach limited the amount of required resin to the inner volume of the plastinate. Then, the plastination sac was put in the incubator for further polymerization and curing. When the foil was removed from the plastinated specimen, the wooden block served as a socket for the grip when sawing. The outer shape of the specimen remained visible. Doing so, the adequate cutting plane could be determined easily. PMID:22209028

Kürtül, Ibrahim; Hammer, Niels; Rabi, Suganthy; Saito, Toshiyuki; Böhme, Jörg; Steinke, Hanno

2011-12-09

162

Synchronous verrucous carcinoma and inverted papilloma of the lacrimal sac: Case report and clinical update.  

PubMed

Inverted papilloma is a benign epithelial tumor of the nasal cavity. It is known to coexist with malignancy in 5 to 13% of cases, with squamous cell carcinoma being the most common malignancy. Another associated malignancy, one that is extremely rare, is verrucous carcinoma. To the best of our knowledge, no case of verrucous carcinoma occurring alone or in association with another neoplasm has been described in the nasolacrimal system. We report a case of synchronous verrucous carcinoma and inverted papilloma of the lacrimal sac in a 47-year-old man. The patient presented with epiphora, nasal obstruction, swelling of the left medial canthus, and drainage of a foul-smelling fluid from the left nostril. Computed tomography and magnetic resonance imaging detected the presence of a large mass occupying the left nasal cavity and sinuses with extension into the nasopharynx. In addition, bony invasion of the anteroinferomedial wall of the left orbit was noted with extension of the tumor into the orbit itself, which resulted in lateral displacement of the left medial rectus muscle. The patient underwent endoscopic debulking of the left sinonasal lesion. Of note, the surgery had to be completed in stages because of excessive blood loss. Histopathologic examination of the intranasal component of the tumor identified it as an inverted papilloma. One month after the intranasal resection, a left dacryocystectomy was performed; histopathologic examination revealed that an invasive verrucous squamous cell carcinoma had arisen within the inverted papilloma. PMID:24170467

Gustafson, Cheryl; Einhorn, Eugene; Scanlon, Mary H; Morgenstern, Kenneth E; Howlett, Paul J; Cohen, Noam A

163

Low-grade fibromyxoid sarcoma arising in the big toe.  

PubMed

Low-grade fibromyxoid sarcoma (LGFMS) is a rare tumor. Reported herein is a case of LGFMS arising in the big toe. The patient was a 58-year-old man who underwent excision of the tumor. The tumor was well-demarcated. Histologically, there were proliferating spindle-shaped tumor cells arranged in a whorled growth pattern, and the stroma showed hyalinized collagen bundles and a myxoid matrix. Nuclear mitotic figures were conspicuous in part. A large rosette-like structure with hyalinized stroma was found, which is characteristic of LGFMS. The differential diagnosis included tumor occurrence in adults; tending to arise in distal extremities; and having bland fibromyxoid histological features, such as fibroma of tendon sheath, low-grade myxofibrosarcoma and acral myxoinflammatory fibroblastic sarcoma. It was not possible to detect the FUS/CREB3L2 and FUS/CREB3L1 fusion genes from the formalin-fixed and paraffin-embedded tissue, although the histological features of the present case were typical of LGFMS. LGFMS may become more common with time, and unique cases may accumulate. PMID:16287497

Kusumi, Tomomi; Nishikawa, Shinji; Tanaka, Masanori; Ogawa, Taro; Jin, Hiromichi; Sato, Fuyuki; Toh, Satoshi; Hasegawa, Tadashi; Kijima, Hiroshi

2005-12-01

164

CHAMP and SAC-C atmospheric occultation results and intercomparisons  

NASA Astrophysics Data System (ADS)

The German Challenging Minisatellite Payload (CHAMP) and Argentine Satelite de Aplicaciones Cientificas-C (SAC-C) Earth science missions, launched in 2000, carry a new generation of Global Positioning System (GPS) receivers for radio occultation sounding of the ionosphere and neutral atmosphere. Though the occultation concept for obtaining profiles of atmospheric temperature, pressure, and moisture was proven in 1995 with GPS/MET, concurrent measurements from CHAMP and SAC-C present the first opportunity for a preliminary evaluation of three central claims: (1) GPS soundings are effectively free of instrumental bias and drift; (2) individual temperature profiles are accurate to <0.5 K between ~5 and 20 km; and (3) averaged profiles for climate studies can be accurate to <0.1 K. These properties imply that a weak climate trend can be monitored and detected in less than a decade and studied by different instruments at different times with no external calibration. While this detection cannot by itself tell us the source of the climate change, whether natural and anthropogenic, this detection is a prerequisite to answer the more difficult problem of understanding the cause of change. In this paper, these three claims are evaluated by comparing nearby CHAMP and SAC-C profiles. Of nearly 130,000 profiles examined, 212 pairs occurring within 30 min and 200 km of one another were found. Profile pairs agree to <0.86 K (68% confidence interval) and to within 0.1 K in the mean between 5 and 15 km altitude, after removing the expected variability of the atmosphere. If the errors in CHAMP and SAC-C are assumed to be uncorrelated, this implies that individual profiles are precise to <0.6 K between 5 and 15 km. Individual comparisons show closest agreement near the tropopause and display finer resolution than and substantially different temperatures from numerical weather model analyses from the European Centre for Medium-Range Weather Forecasts (ECMWF). Comparisons between CHAMP and SAC-C largely indicate precision; however, several features observed in common, especially near the tropopause, tend also to indicate accuracy. Limitations of previous experiments (e.g., GPS/MET) in probing the lower troposphere have significantly improved with CHAMP and SAC-C, with the majority of profiles (60%) descending to the lowest 0.5 km. This is expected to increase to 90-95% with future system improvements. However, the N-bias problem encountered in GPS/MET is also present in CHAMP and SAC-C, and it is expected to be much reduced once open loop tracking is implemented. Examples are selected to illustrate lower tropospheric sensing, including detection of the planetary boundary layer height. For the first time, such performance is achieved with GPS Antispoofing encryption on. Daily occultations currently number ~350-400 this is expected to reach over 1000 in the near future, rivaling the number of semidaily radiosonde launches. With several new missions in planning, this may increase tenfold in the next 3-8 years, making GPS sounding a potentially significant input to numerical weather prediction and climate research.

Hajj, G. A.; Ao, C. O.; Iijima, B. A.; Kuang, D.; Kursinski, E. R.; Mannucci, A. J.; Meehan, T. K.; Romans, L. J.; de la Torre Juarez, M.; Yunck, T. P.

2004-03-01

165

Basal Cell Carcinoma Arising in a Tattooed Eyebrow  

PubMed Central

Malignant skin tumors, including squamous cell carcinoma and malignant melanoma, have occurred in tattoos. Seven documented cases of basal cell carcinoma associated with tattoos have also been reported in the medical literature. We encountered a patient with basal cell carcinoma in a tattooed eyebrow. We report on this case as the eighth reported case of a patient with basal cell carcinoma arising in a tattooed area.

Lee, Jong-Sun; Park, Jin; Kim, Seong-Min; Kim, Han-Uk

2009-01-01

166

MUTATION OF SAC1, AN ARABIDOPSIS SAC DOMAIN PHOSPHOINOSITIDE PHOSPHATASE, CAUSES ALTERATIONS IN CELL MORPHOGENESIS, CELL WALL SYNTHESIS, AND ACTIN ORGANIZATION  

Technology Transfer Automated Retrieval System (TEKTRAN)

SAC (for suppressor of actin) domain proteins in yeast and animals have been shown to modulate the levels of phosphoinositides, thereby regulating several cellular activities such as signal transduction, actin cytoskeleton organization, and vesicle trafficking. Nine genes encoding SAC domain-contai...

167

Does a Myelomeningocele Sac Compared to No Sac Result in Decreased Postnatal Leg Function following Maternal Fetal Surgery for Spina Bifida Aperta?  

Microsoft Academic Search

Objective: A fetus with large sac S1 myelomeningocele (MMC) but bilateral talipes prompted the question, ‘Does the presence or size of an MMC sac affect postnatal leg function?’ Study Design: An MMC database with prenatal, birth, and a minimum of 1-year follow-up evaluation was reviewed. All fetuses had in-utero MMC repair at 20 + 0 to 25 + 6 weeks

R. Douglas Wilson; Mark P. Johnson; Michael Bebbington; Alan W. Flake; Holly L. Hedrick; Leslie N. Sutton; N. Scott Adzick

2007-01-01

168

Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors  

ClinicalTrials.gov

Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Childhood Pineal Parenchymal Tumor

2013-06-10

169

The value of a neighborhood street with reference to the cul-de-sac  

Microsoft Academic Search

This article provides empirical evidence from Halifax, Nova Scotia, confirming the view that the type of neighborhood street can affect home values. The study identifies two categories of streets-the cul-de-sac and the grid-and measures their impacts on home value. The hypothesis that the cul-de-sac would attract premium values was supported by the study. In this study, the cul-de-sac generated a

Paul K. Asabere

1990-01-01

170

Some Factors Determining the Order of Elimination of Culs-de-sac in the Maze  

Microsoft Academic Search

Thirty-five white rats were put through an animal maze with nine culs-de-sac until the correct pathway was run nine times out of ten without any observable tendency to enter a cul-de-sac. The experiment was undertaken with a view to determine the kind of relation existing between the positions of the culs-de-sac and their temporal order of elimination, and the relative

C. J. Warden

1923-01-01

171

Identification and Characterization of Hematopoietic Stem Cells from the Yolk Sac of the Early Mouse Embryo  

Microsoft Academic Search

The yolk sac is the first site of hematopoiesis in the mammalian embryo. However, little is known about the initial stem cells in the yolk sac. We have isolated hematopoietic stem cells from early mouse embryonic yolk sac by using a sequential protocol of nonadherence to plastic, density gradient centrifugation, immunocytoadherence, and cell sorting. Isolated, nonadherent, density <1.077-g\\/cm^3, surface antigen

Hua Huang; Robert Auerbach

1993-01-01

172

The Sac10b Homolog in Methanococcus maripaludis Binds DNA at Specific Sites  

Microsoft Academic Search

The Sac10b protein family, also known as Alba, is widely distributed in Archaea. Sac10b homologs in thermophilic Sulfolobus species are very abundant. They bind both DNA and RNA with high affinity and without sequence specificity, and their physiological functions are still not fully understood. Mma10b from the euryarchaeote Methanococcus maripaludis is a mesophilic member of the Sac10b family. Mma10b is

Yuchen Liu; L. Guo; R. Guo; R. L. Wong; H. Hernandez; J. Hu; Y. Chu; I. J. Amster; W. B. Whitman; L. Huang

2009-01-01

173

Carcinoid Tumors  

PubMed Central

Carcinoid tumors are rare, slow-growing neuroendocrine tumors arising from the enterochromaffin cells disseminated throughout the gastrointestinal and bronchopulmonary systems. Though they have been traditionally classified based upon the embryologic site of origin, morphologic pattern, and silver affinity, newer classification systems have been developed to emphasize the considerable clinical and histopathologic variability of carcinoid tumors found within each embryologic site of origin. These neoplasms pose a diagnostic challenge because they are often innocuous at the time of presentation, emphasizing the need for a multidisciplinary diagnostic approach utilizing biochemical analysis, standard cross-sectional imaging, and newer advances in nuclear medicine. Similarly, treatment of both primary and disseminated carcinoid disease reflects the need for a multidisciplinary approach, with surgery remaining the only curative modality. The prognosis for patients with these tumors is generally favorable, however can be quite variable and is related to the location of the primary tumor, extent of metastatic disease at initial presentation, and the time of diagnosis.

Pinchot, Scott N.; Holen, Kyle; Sippel, Rebecca S.; Chen, Herbert

2010-01-01

174

Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells  

PubMed Central

Background Prostate apoptosis response-4 (Par-4) is a tumor-suppressor protein that selectively activates and induces apoptosis in cancer cells, but not in normal cells. The cancer specific pro-apoptotic function of Par-4 is encoded in its centrally located SAC (Selective for Apoptosis induction in Cancer cells) domain (amino acids 137–195). The SAC domain itself is capable of nuclear entry, caspase activation, inhibition of NF-?B activity, and induction of apoptosis in cancer cells. However, the precise mechanism(s) of how the SAC domain is released from Par-4, in response to apoptotic stimulation, is not well explored. Results In this study, we demonstrate for the first time that sphingosine (SPH), a member of the sphingolipid family, induces caspase-dependant cleavage of Par-4, leading to the release of SAC domain containing fragment from it. Par-4 is cleaved at the EEPD131G site on incubation with caspase-3 in vitro, and by treating cells with several anti-cancer agents. The caspase-3 mediated cleavage of Par-4 is blocked by addition of the pan-caspase inhibitor z-VAD-fmk, caspase-3 specific inhibitor Ac-DEVD-CHO, and by introduction of alanine substitution for D131 residue. Moreover, suppression of SPH-induced Akt dephosphorylation also abrogated the caspase dependant cleavage of Par-4. Conclusion Evidence provided here shows that Par-4 is cleaved by caspase-3 during SPH-induced apoptosis. Cleavage of Par-4 leads to the generation of SAC domain containing fragment which may possibly be essential and sufficient to induce or augment apoptosis in cancer cells.

2013-01-01

175

Angiotropic lymphoma occurring in a lacrimal sac oncocytoma  

PubMed Central

This report describes a case of angiotropic variant of diffuse large B cell lymphoma within a benign oncocytoma of the lacrimal sac. The occurrence of this rare lymphoma within a benign neoplasm has not been documented previously. An 87 year old woman presented with a swelling over the area of the left lacrimal sac, which histological examination revealed to be an oncocytoma. Many small blood vessels within the tumour were filled with large cytologically atypical cells, which stained positively for leucocyte common antigen and a B cell antigen, CD20, confirming the presence of a large B cell non-Hodgkin’s lymphoma of angiotropic type. Angiotropic lymphoma is a very rare and usually highly aggressive variant of non-Hodgkin’s lymphoma, which classically involves the central nervous system and skin, but has been described within most organs. Its occurrence within a benign neoplasm is probably coincidental, although a close association between oncocytic epithelium and normal lymphoid cells is recognised in Warthin’s tumour of salivary and lacrimal glands.

O'Connor, S R; Tan, J H-Y; Walewska, R; Brown, L J R; Lauder, I

2002-01-01

176

SAC and SAC-CI calculations of excitation and circular dichroism spectra of straight-chain and cyclic dichalcogens.  

PubMed

Accurate quantum-chemical calculations of the excitation energies and the rotatory strengths of dichalcogens R-Ch-Ch-R (Ch = S, Se, Te) were carried out with the symmetry adapted cluster (SAC) and SAC-configuration interaction (CI) methods. A series of straight-chain molecules (dihydrogen dichalcogenide, dimethyl dichalcogenide, and (+)-bis(2-methylbutyl) dichalcogenide) and one cyclic molecule (2,3-(R,R)-dichalcogenadecalin) were adopted for comparative analysis. The calculated excitation and circular dichroism (CD) spectra were in good agreement with experimental ones (Laur, P. H. A. In Proceedings of the Third International Symposium on Organic Selenium and Tellurium Compounds; Cagniant, D., Kirsch, G., Eds.; Universite de Metz: Metz, 1979; pp 219-299) within 0.3 eV. The fitting CD spectra also reasonably reproduced the experimental ones. In all the molecules adopted, the first and second lowest bands were assigned to the n-sigma(Ch-Ch) transition and the third and fourth lowest bands to the n-sigma(Ch-R) transition. The first and second lowest bands apparently depended on the R-Ch-Ch-R dihedral angle, suggesting that the orbital energies of two sigma(Ch-Ch) change with the R-Ch-Ch-R dihedral angle. This calculated trend agrees with two empirical rules: the C(2) rule and the quadrant rule. PMID:16913679

Seino, Junji; Honda, Yasushi; Hada, Masahiko; Nakatsuji, Hiroshi

2006-08-24

177

Myofibroblastoma Arising in Mammary Hamartoma: A Case Report  

PubMed Central

Myofibroblastoma (MFB) is a rare mesenchymal tumor arising in breast's soft tissue with a great variety of microscopic features that can be mistaken with a wide variety of biphasic lesions. The authors report a rare case of myofibroblastoma of the breast arising in a mammary hamartoma (MH), present a review of the clinicopathological features of these lesions, and make some diagnostic considerations. The tumour consisted of a well-circumscribed nodule. MFB component comprised about fifty percent of the lesion and was made up of bipolar spindle cells arranged in fascicular clusters separated by bands of hyalinized collagen. There were fat cells and several residual hamartoma glands intermingled and distorted in MFB area. MFB component was positive for Desmin, CD34, bcl-2, and Calponin. To the best of our knowledge, MFB has not been reported in MH, neither has any of the reports described mammary glands joined within MFB.

Uchoa, Diego M.; Cruz, Dennis Baroni; Schaefer, Pedro Guilherme; Pegas, Karla Lais; Cambruzzi, Eduardo

2010-01-01

178

Predicting liquid-phase thermodynamic properties using COSMO-SAC  

NASA Astrophysics Data System (ADS)

Predicting thermodynamic properties of liquids remains a significant challenge in both academia and industry. This is because molecules in the liquid phase are relatively close together but are not arranged in an ordered structure. The COSMO-SAC model uses quantum and statistical mechanics to predict the thermodynamic properties of liquids. In this thesis, a variety of efforts have been made to improve the accuracy of this model. The most successful of these involves the inclusion of dispersion interactions in mixture calculations, which reduces the average prediction error for activity coefficients by over 30%. It has also been demonstrated that the misfit energy—the traditional interaction energy used in all known COSMO-based models—is limited in its ability to model intermolecular interactions. A variety of attempts to improve the electrostatics of the model have been made, but these have had little effect on the overall accuracy. These include use of an expanded hydrogen bonding description, use of an alternate molecular surface construction method, and incorporation of three-dimensional considerations. These results, coupled with the observed improvement obtained from including dispersion interactions, suggest that the greatest weakness in the model is the handling of electrodynamics (how molecules polarize one another), and that future efforts to improve the model should target this area. In addition, the model has been parameterized for the ADF density functional software package, thus making it available to a wider audience. Results are approximately equivalent to those obtained with DMol3, the only package for which a published parameterization was previously available. Of significance, the ADF implementation allows one of the adjustable model parameters to be eliminated. Also, a correlation was found between experimental liquid volumes and the quantum-based molecular volumes employed in COSMO-SAC. This eliminates the need to provide experimental volumes to the model. Finally, a Windows-based graphical user interface for COSMO-SAC has been developed. This expands the availability of the model to anyone with only a general familiarity with thermodynamics. Without this, use is restricted to those with an in-depth knowledge of quantum mechanics, statistical mechanics and computer programming.

Burnett, Russell I.

179

An Isolated Venous Sac as a Novel Site for Cell Therapy in Diabetes Mellitus  

PubMed Central

Background Transplanting pancreatic islets is of significant interest for type 1 diabetes mellitus. After intraportal injection of islets, inferior engraftment and eventual loss of transplanted islets constitute major limitations. Therefore, alternative approaches will be helpful. Here, we evaluated in animals whether an isolated venous sac would support survival of transplanted islets, along with correction of hyperglycemia. Methods Pancreatic islets isolated from adult Lewis rats were transplanted either into an isolated venous sac made from lumbar vein or into the portal vein of syngeneic rats. The integrity and vascular organization of the venous sac was determined by studies of the local microcirculation. The engraftment, survival, and function of transplanted islets were analyzed by histology, including endocrine function in situ and by glycemic control in rats with streptozotocin-induced diabetes. Results Transplanted islets showed normal morphology with insulin expression in isolated venous sac during the long term. Transplanted islets received blood supply from vasa vasorum and had access to drainage through venous tributaries in the venous sac. This resulted in restoration of euglycemia in diabetic rats. Removal of islet graft-bearing venous sac in diabetic rats led to recurrence of hyperglycemia. By contrast, euglycemia was not restored in rats treated by intraportal transplantation of islets. Conclusions We demonstrated that pancreatic islets successfully engrafted and functioned in the isolated venous sac with ability to restore euglycemia in diabetic rats. Therefore, the isolated venous sac offers a new site for transplantation of pancreatic islets. This would be clinically beneficial as an alternative to intrahepatic islet transplantation.

Kakabadze, Zurab; Shanava, Koba; Ricordi, Camillo; Shapiro, A.M. James; Gupta, Sanjeev; Berishvili, Ekaterine

2013-01-01

180

BACTERIOLOGICAL AND PATHOLOGICAL STUDY OF YOLK SAC INFECTION IN BROILER CHICKS IN SULAIMANI DISTRICT  

Microsoft Academic Search

A total of 140 diseased or dead broiler chicks obtained from three different sources in Sulaimani city were necropsied; yolk sac samples from these chicks were cultured and the isolated bacteria were tested for their susceptibility to 8 systemic antimicrobial agents. Unabsorbed yolk sac was observed in 112 chicks associated with signs of septicemia in many cases. These unabsorbed yolk

SUHA A. HUSSEINA; ALI H. HASSANB; RIZGAR R. SULAIMANC

181

Parallel Doppler assessment of yolk sac and intervillous circulation in normal pregnancy and missed abortion  

Microsoft Academic Search

This study assessed yolk sac morphology and vascularity and intervillous blood flow in normal early pregnancy and missed abortion. Transvaginal colour and pulsed Doppler were used in a prospective analysis of 87 normal pregnancies and 48 missed abortions between 6 and 12 weeks gestation. The Kruskal-Wallis rank test was used to calculate the difference in yolk sac diameter and vascularity

A. Kurjak; S. Kupesic

1998-01-01

182

Finite Element Analysis of Stresses Developed in the Blood Sac of a Left Ventricular Assist Device  

PubMed Central

The goal of this research is to develop a 3D finite element (FE) model of a left ventricular assist device (LVAD) to predict stresses in the blood sac. The hyperelastic stress-strain curves for the segmented poly(ether polyurethane urea) blood sac were determined in both tension and compression using a servo-hydraulic testing system at various strain rates. Over the range of strain rates studied, the sac was not strain rate sensitive, however the material response was different for tension versus compression. The experimental tension and compression properties were used in a FE model that consisted of the pusher plate, blood sac and pump case. A quasi-static analysis was used to allow for nonlinearities due to contact and material deformation. The 3D FE model showed that blood sac stresses are not adversely affected by the location of the inlet and outlet ports of the device and that over the systolic ejection phase of the simulation the prediction of blood sac stresses from the full 3D model and an axisymmetric model are the same. Minimizing stresses in the blood sac will increase the longevity of the blood sac in vivo.

Haut Donahue, T. L.; Dehlin, W.; Gillespie, J.; Weiss, W.J.; Rosenberg, G.

2009-01-01

183

IN VITRO/IN VIVO COMPARISON OF YOLK SAC FUNCTION AND EMBRYO DEVELOPMENT  

EPA Science Inventory

Yolk sac function and development of rat embryos grown in vitro for 24 hrs starting on day 10.5 were compared to those of embryos grown in utero. he embryos grown in vitro had significantly fewer somites, shorter crown-rump length and smaller yolk sac diameter when compared to th...

184

Observations on enzymatically isolated, living and fixed embryo sacs in several angiosperm species  

Microsoft Academic Search

A technique has been developed for isolating embryo sacs (ESs) by enzymatic maceration. Ovules were macerated in a mixture of pectinase, cellulase and, in some cases, snailase and pectolyase Y-23. The ovular tissues were removed and the ESs were isolated in toto. Embryo sacs were isolated from both fixed and fresh ovules of Antirrhinum majus L., Helianthus annuus L. and

C. Zhou; H. Y. Yang

1985-01-01

185

Retained Caseous Yolk Sac in a Burmese Python (Python molurus bivittatus)  

Microsoft Academic Search

Retained yolk sacs are common in the domestic chicken and account for consid- erable morbidity and mortality during late em- bryonic development and within the first 10 days of life. What is believed to be the first recorded instance of a retained caseous yolk sac and its successful surgical removal from a Bur- mese python (Python molurus Invittatus) is re-

M. S. Bodri; M. J. Hendrick; R. T. O'Brien; K. K. Sadanaga

186

Molecular Mechanism Underlying the Interaction of Typical Sac10b Family Proteins with DNA  

PubMed Central

The Sac10b protein family is regarded as a family of DNA-binding proteins that is highly conserved and widely distributed within the archaea. Sac10b family members are typically small basic dimeric proteins that bind to DNA with cooperativity and no sequence specificity and are capable of constraining DNA negative supercoils, protecting DNA from Dnase I digestion, and do not compact DNA obviously. However, a detailed understanding of the structural basis of the interaction of Sac10b family proteins with DNA is still lacking. Here, we determined the crystal structure of Mth10b, an atypical member of the Sac10b family from Methanobacterium thermoautotrophicum ?H, at 2.2 Å. Unlike typical Sac10b family proteins, Mth10b is an acidic protein and binds to neither DNA nor RNA. The overall structure of Mth10b displays high similarity to its homologs, but three pairs of conserved positively charged residues located at the presumed DNA-binding surface are substituted by non-charged residues in Mth10b. Through amino acids interchanges, the DNA-binding ability of Mth10b was restored successfully, whereas the DNA-binding ability of Sso10b, a typical Sac10b family member, was weakened greatly. Based on these results, we propose a model describing the molecular mechanism underlying the interactions of typical Sac10b family proteins with DNA that explains all the characteristics of the interactions between typical Sac10b family members and DNA.

Liu, Xi; Wang, Xinquan; Wang, Zhi-Xin; Chen, Yuanyuan; Yao, Hong-Wei; Ge, Meng; Pan, Xian-Ming

2012-01-01

187

Ditheophylline succinate: transfer of theophylline across everted rat intestinal sacs.  

PubMed

The cumulative theophylline transfer rate across 10-cm everted rat intestinal sacs incubated at 37 degrees in pH 7.4 Krebs phosphate buffer was determined. A suspension of ditheophylline succinate ( a potential prodrug of theophylline) and a solution of theophylline at equimolar concentration were evaluated to determine the magnitude of the difference between the cumulative theophylline transfer rates from the two preparations. A linear concentration dependency for the rate across the intestinal wall was evidenced. The theophylline formation rate from ditheophylline succinate suspended in pH 7.4 Krebs buffer at 37 degrees followed apparent zero-order kinetics. The observed difference (fourfold) between the cumulative transfer rates estimated for the theophylline solution and the ditheophylline succinate suspention was attributed to the prevailing theophylline concentration in the mucosal solutions. The biopharmaceutical implication of these observations are discussed. PMID:29956

Sanvordeker, D R

1978-10-01

188

Performances of the SAC-D NIRST flight model radiometer  

NASA Astrophysics Data System (ADS)

Aquarius/SAC-D is a cooperative international mission conducted jointly by the National Aeronautics and Space Administration of the United States of America and the Comisión Nacional de Actividades Espaciales of Argentina. Jointly developed by CONAE and the Canadian Space Agency, the New IR Sensor Technology (NIRST) instrument will monitor high temperature events. NIRST has one band in the mid-wave infrared and two bands in the thermal infrared. The baseline design of the NIRST is based on microbolometer technology developed jointly by INO and the CSA. This paper will first present an overview of the design of the NIRST camera module. The manufacturing and qualification activities for the Flight Model will be described and key performance parameters, as measured during the verification campaign, will be reported.

Leclerc, Mélanie R.; Marchese, Linda; Côté, Patrice; Châteauneuf, François; Chevalier, Claude; Marraco, Hugo; Ngo Phong, Linh

2009-08-01

189

On modelling SAC's regions in early type atmospheres  

NASA Astrophysics Data System (ADS)

We test the ideas that probably DACs are not unknown absorption spectral lines, but spectral lines (satellite absorption components) of the same ion and the same wavelength as a main spectral line, shifted at different ??. In addition, DACs are not always discrete absorption spectral lines, but in most cases lines that are blended among themselves as well as with the main spectral line. This means that when we deal with a significant spectral line, which is accompanied by satellite absorption components, we should not regard them as independent spectral lines, but as a unified formation which must be dealt with as one spectral line splited into a series of components. For these reasons we prefer to name them Satellite Absorption Components (SACs) and not discrete Absorption components (DACs).

Danezis, E.; Lyratzi, E.; Nikolaidis, D.; Stathopoulou, M.; Theodossiou, E.; Drakopoulos, C.; Soulikias, A.; Antoniou, A.

2003-10-01

190

[The value of cytology in the diagnosis of extragonadal germ cell tumors].  

PubMed

Extragonadic germinal tumors are frequently mixed tumors. When a metastatic sacrococcygeal teratoma is clinically suspected in children, a yolk-sac tumor component could be judiciously demonstrated by either an elevated serum level of alphafoetoprotein (AFP), or fine needle aspiration cytology. We report the case of a 25 month aged girl presenting a metastatic sacrococcygeal tumor (lymph node and bone metastasis) with high level of AFP (34.100 microg/ml). Fine needle aspiration cytology identified the yolk sac tumor component, characterized by papillae and glandular clusters, composed of pale isomorphic cells with vesicular and nucleolated nucleus and some intracytoplasmic hyaline globules. The yolk sac tumor component could not be identified in the sacrococcygeal surgical specimen, exclusively composed of immature teratoma. PMID:15567952

Mrad, Karima; Abid, Leila; Oubiche, Faysal; Driss, Maha; Abbes, Imene; Sassi, Samia; Ben Romdhane, Khaled

2004-09-01

191

Osteosarcoma Tumor Thrombus  

PubMed Central

Tumor thrombus arising from osteosarcoma is rare. We report the case of a 20-year-old man with proximal humerus osteosarcoma, accompanied by an extensive intravascular tumor thrombus extending into the heart. Our review of the literature found 14 previous reports on osteosarcoma with tumor thrombus. The combination of positron emission tomography and computed tomography is very useful in differentiating tumor thrombus from vascular thrombus, thereby avoiding unnecessary anticoagulation therapy. This same imaging combination can also be used to evaluate the response to treatment. Surgical resection of the tumor thrombus is highly recommended. The effect of tumor thrombus on survival is still unknown.

Navalkele, Pournima; Jones, Sarah M.; Jones, Jason K.; Salazar, Jorge D.; Toy, Patrick C.; Iyer, Rathi V.; Herrington, Betty

2013-01-01

192

Potential impact of therapeutic warfarin treatment on type II endoleaks and sac shrinkage rates on midterm follow-up examination  

Microsoft Academic Search

Objective: Successful endovascular aortic aneurysm repair depends on exclusion and spontaneous thrombosis of the aneurysm sac. The need for chronic postoperative anticoagulation therapy could limit the applicability of this technology with delay or prevention of sac thrombosis resulting in endoleak formation and altered remodeling of the aneurysm sac. The purpose of this study was the determination of whether chronic therapeutic

Ronald M. Fairman; Jeffrey P. Carpenter; Richard A. Baum; Robert A. Larson; Michael A. Golden; Clyde F. Barker; Marc E. Mitchell; Omaida C. Velazquez

2002-01-01

193

Lesser sac endoscopy and laparoscopy in pancreatic carcinoma definitive diagnosis, staging and palliation.  

PubMed

Laparoscopy with lesser sac endoscopy (LSE) were used in combination from 1987 to 1992 in 103 patients for differentiation between pancreatic carcinoma and other peripancreatic pathology, staging, and palliation. LSE identified pancreatic carcinoma in 38 patients; pancreatic cystadenocarcinoma in 2 patients; pancreatic cystadenoma in 3 patients; pancreatic adenoma in 1 patient; pancreatic metastases from liver in 2 patients; and pancreatic cysts in 5 patients. False negative diagnosis of pancreatic carcinoma occurred in two cases. Nontumor pancreatic pathology was revealed in 10 patients. Specifically, acute pancreatitis was found in four patients, and chronic pancreatitis was found in six patients. Extrapancreatic cancers were identified in 15 patients: retroperitoneal extraorgan tumors were found in 2 patients; extrahepatic biliary tract cancer in 6 patients; gallbladder cancer in 1 patient; liver cancer in 3 patients; and stomach cancer in 1 patient. In five cases no pathology was found. Overall correct definitive diagnosis was established in 101 patients. Sensitivity of laparoscopy with LSE for pancreatic carcinoma diagnosis proved to be 95 per cent (38 of 40 patients), for pancreatic tumors diagnosis 96.22 per cent (51 of 53 patients); specificity of the method 100 per cent; and accuracy of diagnosis 98 per cent (101 of 103 patients). Thus, the accuracy of the method was as high as the accuracy of combination of all known modalities. Criteria of unresectability were revealed with the combination of LSE and laparoscopy in 75 per cent (30 of 40 cases) of pancreatic carcinoma. Moreover, laparoscopy allowed palliation of pancreatic carcinoma. Laparoscopic cholecystostomy was performed in 10 patients, and laparoscopic cholecystojejunostomy with enteroenterostomy was performed in 6 patients. PMID:9731805

Charukhchyan, S A; Lucas, G W

1998-09-01

194

Conjunctival sac bacterial flora isolated prior to cataract surgery  

PubMed Central

Objective To determine the trends of conjunctival sac bacterial flora isolated from patients prior to cataract surgery. Subjects and methods The study comprised 579 patients (579 eyes) who underwent cataract surgery. Specimens were collected by lightly rubbing the inferior palpebral conjunctival sac with a sterile cotton swab 2 weeks before surgery, and then cultured for isolation of bacteria and antimicrobial sensitivity testing. The bacterial isolates and percentage of drug-resistant isolates were compared among age groups and according to whether or not patients had diabetes mellitus, hyperlipidemia, dialysis therapy, oral steroid use, dry eye syndrome, or allergic conjunctivitis. Results The bacterial isolation rate was 39.2%. There were 191 strains of Gram-positive cocci, accounting for the majority of all isolates (67.0%), among which methicillin-sensitive coagulase-negative staphylococci was the most frequent (127 strains, 44.5%), followed by methicillin-resistant coagulase-negative staphylococci (37 strains, 12.7%). All 76 Gram-positive bacillary isolates (26.7%) were from the genus Corynebacterium. Among the 16 Gram-negative bacillary isolates (5.9%), the most frequent was Escherichia coli (1.0%). The bacterial isolation rate was higher in patients >60 years old, and was lower in patients with dry eye syndrome, patients under topical treatment for other ocular disorders, and patients with hyperlipidemia. There was no significant difference in bacterial isolation rate with respect to the presence/absence of diabetes mellitus, steroid therapy, dialysis, or a history of allergic conjunctivitis. Methicillin-resistant coagulase-negative staphylococci showed a significantly higher detection rate in diabetic patients than nondiabetic patients (20.3% versus 7.0%, P < 0.05). The percentage of all isolates resistant to levofloxacin, cefmenoxime, and tobramycin was 14.0%, 15.2%, and 17.9%, respectively, with no significant differences among these drugs. Conclusion The high bacterial isolation rate in patients >60 years old and the high methicillin-resistant coagulase-negative staphylococci isolation rate in patients with diabetes are important to consider for prevention of perioperative infections.

Suto, Chikako; Morinaga, Masahiro; Yagi, Tomoko; Tsuji, Chieko; Toshida, Hiroshi

2012-01-01

195

XPS of oxygen atoms on Ag(111) and Ag(110) surfaces: accurate study with SAC/SAC-CI combined with dipped adcluster model.  

PubMed

O1s core-electron binding energies (CEBE) of the atomic oxygens on different Ag surfaces were investigated by the symmetry adapted cluster-configuration interaction (SAC-CI) method combined with the dipped adcluster model, in which the electron exchange between bulk metal and adsorbate is taken into account properly. Electrophilic and nucleophilic oxygens (O(elec) and O(nuc)) that might be important for olefin epoxidation in a low-oxygen coverage condition were focused here. We consider the O1s CEBE as a key property to distinguish the surface oxygen states, and series of calculation was carried out by the Hartree-Fock, Density functional theory, and SAC/SAC-CI methods. The experimental information and our SAC/SAC-CI results indicate that O(elec) is the atomic oxygen adsorbed on the fcc site of Ag(111) and that O(nuc) is the one on the reconstructed added-row site of Ag(110) and that one- and two-electron transfers occur, respectively, to the O(elec) and O(nuc) adclusters from the silver surface. PMID:23677698

Ishikawa, Atsushi; Nakatsuji, Hiroshi

2013-05-16

196

Effects of SAC on oxidative stress and NO availability in placenta: potential benefits to preeclampsia.  

PubMed

Preeclampsia (PE) is a major cause of fetal growth restriction and perinatal mortality, which involves oxidative stress and vasodilator signaling disorder. S-allyl-L-cysteine (SAC) is one of the most abundant compounds in garlic extracts, and possesses several biological activities. This research was designed to investigate the protective effects of SAC against H(2)O(2)-induced oxidative insults, as well as the effects on NO/cGMP signaling pathway in placenta. We used TEV-1 cells and placental explants to detect the effects of SAC. TEV-1 cells and human placental explants were separately exposed to SAC, H(2)O(2), or a combination of H(2)O(2) and SAC. Intracellular ROS was detected by flow cytometry; the NO level was detected by an NO metabolites (NOx) assay; the cGMP level was simultaneously measured by the method of radioimmunoassay; the expression of eNOS in TEV-1 cells was measured by immunochemistry and Western blot. Our findings showed that H(2)O(2) treatment increased ROS productions in TEV-1 cells and significantly decreased cGMP and NO level either in TEV-1 cells or explants compared to the control groups (p < 0.05). The expression of eNOS in TEV-1 cells also significantly decreased in H(2)O(2) treated group compared to the control group (p < 0.05). Co-treatment of H(2)O(2) and SAC significantly decreased ROS productions, and increased NO, cGMP and eNOS level compared to the H(2)O(2) treated alone groups (p < 0.05), which were all reverted back to near control levels. Further more, SAC treatment increased NO and cGMP level of TEV-1 cells and explants in a dose-dependent manner even at non-oxidative stress status (p < 0.05). However, when the TEV-1 cells were cultured in the presence of NOS inhibitor (L-NAME) and NO donor (SNP), additional SAC treatment still significantly increased the NO level in comparison with SAC non-treated group (p < 0.05). In conclusion, these results demonstrate that ROS (H(2)O(2)-mediated) can induce insults to NO/cGMP pathway, while SAC could antagonize this insult. And SAC also possesses the ability to increase NO and cGMP level at non-oxidative stress status in TEV-1 cells and placenta explants. SAC is therefore hypothesized to be a potential drug for PE treatment. PMID:22405339

Yu, J; Feng, L; Hu, Y; Zhou, Y

2012-03-08

197

An unusual feature of yolk sac placentation in Necromys lasiurus (Rodentia, Cricetidae, Sigmodontinae).  

PubMed

We studied the development of the inverted yolk sac in a New World rodent, Necromys lasiurus during early placentation. Ten implantation sites were investigated by means of histology, immunohistochemistry and electron microscopy. The yolk sac was villous near its attachment to the placenta. Elsewhere it was non-villous and closely attached to the uterus. The uterine glands were shallow and wide mouthed. They were associated with vessels and filled with secretion, suggesting the release of histotroph. This feature was absent at later stages. The intimate association of the yolk sac with specialized glandular regions of the uterus may represent a derived character condition of Necromys and/or sigmodont rodents. PMID:22541609

Favaron, P O; Carter, A M; Mess, A M; de Oliveira, M F; Miglino, M A

2012-04-26

198

Endodermal Sinus Tumor of Vagina in Infants  

PubMed Central

Abstract Endodermal sinus tumor (or Yolk Sac tumor) of the vagina is a rare malignant germcell tumor which is seen exclusively in children younger than 3 years of age. We report two cases of endodermal sinus tumor of the vagina. In both cases no radiological investigation was done and serum alpha-fetoprotein was elevated. The histopathological examination of both the tumor masses revealed vaginal endodermal sinus tumor. Periodic-acid-Schiff stain with diastase showed diastase resistant hyaline globules. These findings confirmed the diagnosis of endodermal sinus tumor in both cases. Vaginal endodermal sinus tumor is both locally aggressive and capable of metastasis. The serum alpha-fetoprotein level is a useful marker for diagnosis and monitoring the recurrence of vaginal endodermal sinus tumor in infants. Early detection and therapy is important because of its aggressive nature and good response to chemotherapy.

Chauhan, Smita; Nigam, Jitendra Singh; Singh, Pallavi; Misra, Vatsala; Thakur, Brijesh

2013-01-01

199

Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels.  

PubMed

In adult mammals, leukocyte recruitment follows a well-defined cascade of adhesion events enabling leukocytes to leave the circulatory system and transmigrate into tissue. Currently, it is unclear whether leukocyte recruitment proceeds in a similar fashion during fetal development. Considering the fact that the incidence of neonatal sepsis increases dramatically with decreasing gestational age in humans, we hypothesized that leukocyte recruitment may be acquired only late during fetal ontogeny. To test this, we developed a fetal intravital microscopy model in pregnant mice and, using LysEGFP (neutrophil reporter) mice, investigated leukocyte recruitment during fetal development. We show that fetal blood neutrophils acquire the ability to roll and adhere on inflamed yolk sac vessels during late fetal development, whereas at earlier embryonic stages (before day E15), rolling and adhesion were essentially absent. Accordingly, flow chamber experiments showed that fetal EGFP(+) blood cells underwent efficient adhesion only when they were harvested on or after E15. Fluorescence-activated cell sorter analysis on EGFP(+) fetal blood cells revealed that surface expression of CXCR2 and less pronounced P-selectin glycoprotein ligand-1 (PSGL-1) begin to increase only late in fetal life. Taken together, our findings demonstrate that inflammation-induced leukocyte recruitment is ontogenetically regulated and enables efficient neutrophil trafficking only during late fetal life. PMID:23525796

Sperandio, Markus; Quackenbush, Elizabeth J; Sushkova, Natalia; Altstätter, Johannes; Nussbaum, Claudia; Schmid, Stephan; Pruenster, Monika; Kurz, Angela; Margraf, Andreas; Steppner, Alina; Schweiger, Natalie; Borsig, Lubor; Boros, Ildiko; Krajewski, Nele; Genzel-Boroviczeny, Orsolya; Jeschke, Udo; Frommhold, David; von Andrian, Ulrich H

2013-03-22

200

Observational Opportunities with the CUBIC Experiment on SAC-B  

NASA Astrophysics Data System (ADS)

The CUBIC experiment on the SAC-B satellite is now collecting data on the Diffuse X-Ray Background and bright point sources over an energy range of 0.2 - 10 keV with energy resolution ranging from 40 - 160 eV over this bandpass. CUBIC observations, several of which are discussed in other posters at this session, provide 2 - 4 high quality spectra per week. CUBIC was built as a PI-class instrument, and at present data rights are divided between Penn State (90%) and Leicester University (10%). We present the observing plan for the first six months of CUBIC operations. We are currently collaborating with several astronomers who are not on the CUBIC team but have expressed interest in one or more of these targets. We invite additional collaborations on targets which are not currently assigned to a specific observer. In order to make these data more accessible to the astronomical community, we are proposing to institute a modest Guest Investigator program. If supported by ADP funding, this would permit observing requests from outside astronomers and would place a large fraction of the CUBIC data in a public archive at the HEASARC.

Nousek, J. A.; Burrows, D. N.; Moskalenko, E. I.

1996-12-01

201

Adnexal and cul-de-sac abnormalities: transvaginal sonography.  

PubMed

Sixty-seven patients selectively chosen from 354 undergoing conventional transabdominal (TA) sonography for evaluation of a clinically suspected adnexal mass subsequently underwent transvaginal (TV) sonography either because the TA sonograms were technically suboptimal or because it was not possible to characterize with certainty an abnormality identified with TA sonography. TV sonography added diagnostically useful information in 25 of 28 patients with cystic pathologic changes in the adnexa uteri. Eight of 12 patients with tuboovarian abscess and nonspecific adnexal masses visualized with TA sonography had tube-shaped fluid collections characteristic of pyosalpinx identified with TV sonography. TV sonography added diagnostically useful information in all seven patients with diseases of the cul-de-sac (rectouterine fossa) and allowed differentiation of adnexal from primary uterine disease in three patients with TA sonograms on which findings were equivocal. It also expedited the diagnosis of a tubal pregnancy in ten of 14 patients and was useful in the detection of adhesions and perforated intrauterine devices. These results indicate that adjunctive TV sonography can provide important diagnostic information. PMID:3275977

Lande, I M; Hill, M C; Cosco, F E; Kator, N N

1988-02-01

202

SAC-B GaAs solar array  

NASA Astrophysics Data System (ADS)

This paper describes the electrical and mechanical design of the GaAs solar array of SAC-B, an Argentinian scientific satellite, planned for launch in 1995 into a 550-km circular orbit by Pegasus vehicle. The solar array is made up of four deployable wings, embodying approximately 1000 LPE GaAs solar cells, (30 x 41 sq mm), capable of providing about 215 W at 28 V at EOL. The mechanical structure of each panel comprises an aluminum honeycomb structure with carbon fiber skins; the active facesheet is covered with an insulating layer of kapton/fiberglass. Each panel is attached via a pair of hinges to the spacecraft body while a restraint/release mechanism holds the other panel edge to the spacecraft. Different considerations have been taken into account for the electrical and mechanical design of the solar array: geometrical constraints of the Pegasus static envelope and the satellite for the panel dimensioning, mission degradation factors, minimization of the magnetic moment, and realiability requirements. Several environmental tests (including thermal vacuum and vibration) are foreseen at panel and/or satellite level to verify performances during the mission.

Brambilla, L.; Caon, A.; Contini, R.; D'Accolti, G.; Rossi, E.; Verzeni, G.; Flores, C.; Paletta, F.; Pedrazzoli, G.; Grattarola, M.

1993-10-01

203

Deformation and creep in the human chorioamniotic sac.  

PubMed

This paper presents a review of physical principles involved in deformation and creep in the human chorioamniotic membrane. These are definable rheological properties found in many materials. Experimental data are presented on 66 human fetal membranes. A difference in the stress tolerance between preterm and term membranes is demonstrated. A computer model has been devised which allows for the calculation of changes in thickness of the membrane at the point of fracture. This computer model allows for the study of the physical property of the tissue in ways which have not previously been suggested. The model suggests that the pathophysiology related to rupture of the membrane is based on changes in the thickness of this tissue occurring secondary to acute and chronic stress applications. The data derived in these experiments suggest a possible physical model for rupture of the membranes; they also introduce questions regarding the anatomic and biochemical makeup of the chorion and the amnion and the respective role that each plays in maintaining the integrity of the human chorioamniotic sac. PMID:453271

Lavery, J P; Miller, C E

1979-06-15

204

Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis.  

PubMed

The enucleated definitive erythrocytes of mammals are unique in the animal kingdom. The observation that yolk sac-derived primitive erythroid cells in mammals circulate as nucleated cells has led to the conjecture that they are related to the red cells of fish, amphibians, and birds that remain nucleated throughout their life span. In mice, primitive red cells express both embryonic and adult hemoglobins, whereas definitive erythroblasts accumulate only adult hemoglobins. We investigated the terminal differentiation of murine primitive red cells with use of antibodies raised to embryonic beta H1-globin. Primitive erythroblasts progressively enucleate between embryonic days 12.5 and 16.5, generating mature primitive erythrocytes that are similar in size to their nucleated counterparts. These enucleated primitive erythrocytes circulate as late as 5 days after birth. The enucleation of primitive red cells in the mouse embryo has not previously been well recognized because it coincides with the emergence of exponentially expanding numbers of definitive erythrocytes from the fetal liver. Our studies establish a new paradigm in the understanding of primitive erythropoiesis and support the concept that primitive erythropoiesis in mice shares many similarities with definitive erythropoiesis of mammals. PMID:15031208

Kingsley, Paul D; Malik, Jeffrey; Fantauzzo, Katherine A; Palis, James

2004-03-18

205

Composite hemangioendothelioma arising from the kidney: case report with review of the literature.  

PubMed

Reported herein is a medical curiosities vascular tumor primary arising from the kidney and exhibiting unique histopathological features. A 32-year-old woman underwent a total nephrectomy of right kidney because of a mass localized in the inferior pole. Distinct from other vascular lesions, on histology the tumor had a peculiar composite pattern, consisting of benign and malignant vascular components, which were haphazardly intermixed without any definite margins. The malignant component was composed of epithelioid hemangioendothelioma (45%) and angiosarcoma (50%) with moderate differentiation. Immunohistochemically, the oval to cuboidal to spindle tumor cells expressed only endothelial markers (CD31, CD34 and factor VIII-related antigen). And the angiosarcomatous component was characterized by the presence of a greater proliferation index Ki-67. Unlike other epithelial tumors, smooth muscle actin (SMA), cytokeratin, EMA and S-100 were all negative in the epithelioid tumor cells. These findings led to the diagnosis of a low-grade vascular neoplasm with morphological features consistent with so-called composite hemangioendothelioma (CHE). At 11 month follow up the patient was alive, without evidence of tumor recurrence. CHE is an extremely rare vascular neoplasm, with borderline malignant potential, which mostly occurs in distal extremity of the limbs at the cutaneous level and, only 30 cases have been previously described until now. To our knowledge, this is the first report of CHE arising from the kidney and widens the spectrum of primary vascular tumors arising in the kidney. PMID:24040461

Zhang, Jin; Wu, Bo; Zhou, Gui-Qian; Zhang, Ru-Song; Wei, Xue; Yu, Bo; Lu, Zhen-Feng; Ma, Heng-Hui; Shi, Qun-Li; Zhou, Xiao-Jun

2013-08-15

206

Composite hemangioendothelioma arising from the kidney: case report with review of the literature  

PubMed Central

Reported herein is a medical curiosities vascular tumor primary arising from the kidney and exhibiting unique histopathological features. A 32-year-old woman underwent a total nephrectomy of right kidney because of a mass localized in the inferior pole. Distinct from other vascular lesions, on histology the tumor had a peculiar composite pattern, consisting of benign and malignant vascular components, which were haphazardly intermixed without any definite margins. The malignant component was composed of epithelioid hemangioendothelioma (45%) and angiosarcoma (50%) with moderate differentiation. Immunohistochemically, the oval to cuboidal to spindle tumor cells expressed only endothelial markers (CD31, CD34 and factor VIII-related antigen). And the angiosarcomatous component was characterized by the presence of a greater proliferation index Ki-67. Unlike other epithelial tumors, smooth muscle actin (SMA), cytokeratin, EMA and S-100 were all negative in the epithelioid tumor cells. These findings led to the diagnosis of a low-grade vascular neoplasm with morphological features consistent with so-called composite hemangioendothelioma (CHE). At 11 month follow up the patient was alive, without evidence of tumor recurrence. CHE is an extremely rare vascular neoplasm, with borderline malignant potential, which mostly occurs in distal extremity of the limbs at the cutaneous level and, only 30 cases have been previously described until now. To our knowledge, this is the first report of CHE arising from the kidney and widens the spectrum of primary vascular tumors arising in the kidney.

Zhang, Jin; Wu, Bo; Zhou, Gui-Qian; Zhang, Ru-Song; Wei, Xue; Yu, Bo; Lu, Zhen-Feng; Ma, Heng-Hui; Shi, Qun-Li; Zhou, Xiao-Jun

2013-01-01

207

ARISE: American renaissance in science education.  

National Technical Information Service (NTIS)

The national standards and state derivatives must be reinforced by models of curricular reform. In this paper, ARISE presents one model based on a set of principles--coherence, integration of the sciences, movement from concrete ideas to abstract ones, in...

1998-01-01

208

ARISE: American renaissance in science education  

SciTech Connect

The national standards and state derivatives must be reinforced by models of curricular reform. In this paper, ARISE presents one model based on a set of principles--coherence, integration of the sciences, movement from concrete ideas to abstract ones, inquiry, connection and application, sequencing that is responsive to how people learn.

NONE

1998-09-14

209

A surgical window to access the obliterated posterior cul-de-sac at vaginal hysterectomy  

Microsoft Academic Search

ObjectiveTo perform vaginal hysterectomy and adnexectomy without laparoscopic assistance in women with ovarian endometriosis by accessing the posterior cul-de-sac via the posterior uterocervical–broad ligament space.

Shirish S. Sheth

2009-01-01

210

Laparoscopic Mobilization of the Rectosigmoid and Excision of the Obliterated Cul-de-sac  

Microsoft Academic Search

Study ObjectiveTo evaluate the feasibility and surgical and clinical outcomes of laparoscopic excision of anterior recto- sigmoid wall endometriosis and en bloc dissection of the obliterated cul-de-sac.

Jackie Hollett-Caines; George A. Vilos; Deborah Anne Penava

2003-01-01

211

Endovascular conversion with femorofemoral bypass as a treatment of endotension and aneurysm sac enlargement.  

PubMed

We report a case of a patient treated with a Gore Excluder endograft for AAA in November 2003 with subsequent aneurysm sac enlargement in the absence of an identified endoleak. The patient had a Type I endoleak treated with a Palmaz stent at the neck and later developed a Type II endoleak treated with translumbar coil embolization. This was successful with absence of pressure in the sac after the procedure and stable aneurysm size over the next nine months. Surveillance of the patient with both CT and ultrasound then revealed an increase in the aortic sac diameter in the absence of endoleak. A Cook Zenith converter was used to reline this PTFE endograft. Subsequently, imaging showed aneurysm sac shrinkage. This is a report of endotension with aneurysm expansion following Gore Excluder placement which was treated successfully with a dacron endograft. PMID:17264023

Smith, Stephen T; Clagett, G Patrick; Arko, Frank R

2007-02-01

212

Coagulopathy Associated with Sac Reperfusion for Reversing Paraplegia After Endovascular Repair of Type II Thoracoabdominal Aneurysm.  

PubMed

Sac perfusion may be helpful in preventing or reversing spinal cord injury after endovascular repair of thoracoabdominal aneurysms and it has been used as an adjunct to the standard physiologic measures of sustained hypertension and cerebrospinal fluid drainage. Coagulopathy as a result of endoleak after endovascular aneurysm repair has been reported, and very rare cases of treatment after repair of these endoleaks have been described. We report a 73-year-old man who had endovascular repair of a type II thoracoabdominal aneurysm with a branched stent graft. Sac reperfusion was initiated to manage postoperative paraplegia. The paraplegia partially resolved but severe hemorrhagic complications developed that were attributed to sac perfusion-related hyperfibrinolysis. Discontinuation of sac perfusion resolved the coagulopathy but resulted in paraplegia. PMID:23988546

Lioupis, Christos; Katsanos, Konstantinos; Clough, Rachel; Matharu, Nick; Modarai, Bijan; Carrell, Tom; Taylor, Peter

2013-08-26

213

Performance Evaluation of Hybrid SCM/SAC-OCDMA Transmissions System using Dynamic Cyclic Shift Code  

NASA Astrophysics Data System (ADS)

In this paper, the performance of a hybrid scheme of Subcarrier Multiplexing (SCM) technique in a Spectral Amplitude Coding (SAC) Optical Code Division Multiple Access (CDMA) transmissions system is evaluated. The hybrid system is design using new code family; we call it Dynamic Cyclic Shift (DCS) code. The DCS code design for SAC-OCDMA system to reduce the effect of Multi Access Interference due to it property of low cross-correlation (?C ? 1) between code words. In contrast, the SCM scheme shows the ability to increase the data rate of SAC-OCDMA system. Consequently, the hybrid SCM/SAC-OCDMA system could be one promising solution to the high-capacity access network with low cost effective, good flexibility and enhanced security, which makes an attractive candidate for next-generation broadband access network.

Abd, Thanaa Hussein; Aljunid, S. A.; Fadhil, Hilal Adnan; Radhi, Ibrahim Fadhil; Saad, N. M.

2012-12-01

214

Evidence for Avian Intrathoracic Air Sacs in a New Predatory Dinosaur from Argentina  

PubMed Central

Background Living birds possess a unique heterogeneous pulmonary system composed of a rigid, dorsally-anchored lung and several compliant air sacs that operate as bellows, driving inspired air through the lung. Evidence from the fossil record for the origin and evolution of this system is extremely limited, because lungs do not fossilize and because the bellow-like air sacs in living birds only rarely penetrate (pneumatize) skeletal bone and thus leave a record of their presence. Methodology/Principal Findings We describe a new predatory dinosaur from Upper Cretaceous rocks in Argentina, Aerosteon riocoloradensis gen. et sp. nov., that exhibits extreme pneumatization of skeletal bone, including pneumatic hollowing of the furcula and ilium. In living birds, these two bones are pneumatized by diverticulae of air sacs (clavicular, abdominal) that are involved in pulmonary ventilation. We also describe several pneumatized gastralia (“stomach ribs”), which suggest that diverticulae of the air sac system were present in surface tissues of the thorax. Conclusions/Significance We present a four-phase model for the evolution of avian air sacs and costosternal-driven lung ventilation based on the known fossil record of theropod dinosaurs and osteological correlates in extant birds: (1)?Phase I—Elaboration of paraxial cervical air sacs in basal theropods no later than the earliest Late Triassic. (2)?Phase II—Differentiation of avian ventilatory air sacs, including both cranial (clavicular air sac) and caudal (abdominal air sac) divisions, in basal tetanurans during the Jurassic. A heterogeneous respiratory tract with compliant air sacs, in turn, suggests the presence of rigid, dorsally attached lungs with flow-through ventilation. (3)?Phase III—Evolution of a primitive costosternal pump in maniraptoriform theropods before the close of the Jurassic. (4)?Phase IV—Evolution of an advanced costosternal pump in maniraptoran theropods before the close of the Jurassic. In addition, we conclude: (5)?The advent of avian unidirectional lung ventilation is not possible to pinpoint, as osteological correlates have yet to be identified for uni- or bidirectional lung ventilation. (6)?The origin and evolution of avian air sacs may have been driven by one or more of the following three factors: flow-through lung ventilation, locomotory balance, and/or thermal regulation.

Sereno, Paul C.; Martinez, Ricardo N.; Wilson, Jeffrey A.; Varricchio, David J.; Alcober, Oscar A.; Larsson, Hans C. E.

2008-01-01

215

Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment  

ClinicalTrials.gov

Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Metastatic Childhood Soft Tissue Sarcoma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Childhood Visual Pathway Glioma; Unspecified Childhood Solid Tumor, Protocol Specific

2013-09-27

216

Social Cohesiveness, Territoriality, and Holiday DecorationsThe Influence of Cul-de-Sacs  

Microsoft Academic Search

Altman's territoriality theory was used as a framework for examining neighborhood attachment. We hypothesized that attachment would be manifested in interrelated patterns of neighboring behaviors, attitudes indicating that the block was a secondary territory, and individual and communal displays of holiday decorations. Design features of cul-de-sacs were hypothesized to contribute to greater degrees of block attachment on cul-de-sacs than on

Barbara B. Brown; Carol M. Werner

1985-01-01

217

Tonicity of human tear fluid sampled from the cul-de-sac  

Microsoft Academic Search

A 'freezing point' depression technique was used to determine the osmolality of 384 samples of tear fluid originating from the middle of the lower tear prism and the lower cul-de-sac of one eye of each of 12 young adults. Tear fluid from the cul-de-sac (mean 341.0 mosm\\/kg) was found overall to be significantly hypertonic (p less than 0.0001) relatively to

W J Benjamin; R M Hill

1989-01-01

218

Terminal differentiation of yolk-sac erythroid cells of the Syrian hamster in vitro  

Microsoft Academic Search

The developmental fate of Syrian hamster yolk-sac (primitive) erythroid cells was examined in vitro. Highly purified yolk-sac erythroid cells at the polychromatophilic stage, obtained from the peripheral blood of embryos at day 10 of gestation, showed morphological and biochemical changes in our modified semi-solid culture system. Several morphological changes observed in the primitive erythroid cell cultures, such as nuclear condensation,

Kiyokazu Morioka; Reiko Minamikawa-Tachino

1991-01-01

219

Evidence for Avian Intrathoracic Air Sacs in a New Predatory Dinosaur from Argentina  

Microsoft Academic Search

BackgroundLiving birds possess a unique heterogeneous pulmonary system composed of a rigid, dorsally-anchored lung and several compliant air sacs that operate as bellows, driving inspired air through the lung. Evidence from the fossil record for the origin and evolution of this system is extremely limited, because lungs do not fossilize and because the bellow-like air sacs in living birds only

Paul C. Sereno; Ricardo N. Martinez; Jeffrey A. Wilson; David J. Varricchio; Oscar A. Alcober; Hans C. E. Larsson; Tom Kemp

2008-01-01

220

Molecular mechanisms underlying ectopic otoconia-like particles in the endolymphatic sac of embryonic mice.  

PubMed

Otoconin-90, the principal otoconial matrix protein, provided a tool to investigate the molecular mechanism of otoconial morphogenesis. The endolymphatic sac of the embryonic chick and guinea pig contain otoconia. Here, we show that the embryonic mouse transiently expresses ectopic otoconia in the endolymphatic sac. Massive precipitate of otoconin-90-positive material is detectable in the lumen of the endolymphatic sac between embryonic day 14.5 and 17.5 with frequent accretion into more heavily staining otoconia-like particles. Otoconin-90 was also localized at the surface and the interior of epithelial cells lining the endolymphatic sac as well as incorporated into free floating cells. In contrast, in situ hybridization failed to detect mRNA in the endolymphatic duct and sac, even though the adjacent nonsensory vestibular structures are heavily stained. Because of ample expression of otoconin-90 protein in the absence of the corresponding mRNA, we conclude that the luminal otoconin-90 is imported via longitudinal flow from the vestibular compartments, where both mRNA and protein are strongly expressed. Because of absence of mRNA, the expression of the corresponding protein by the epithelia lining the endolymphatic sac can only be explained by a resorptive process, as previously proposed on the basis of the movement of luminal macromolecules. The data do not support the previous hypothesis that the transient expression of otoconia-like particles of the endolymphatic sac represents a vestigial phenomenon from the amphibian stage, since amphibia express ample mRNA encoding otoconin-22 in the endolymphatic sac system. PMID:15276677

Ignatova, Elena G; Thalmann, Isolde; Xu, Baogang; Ornitz, David M; Thalmann, Ruediger

2004-08-01

221

Fertilization in Nicotiana tabacum : ultrastructural organization of propane-jet-frozen embryo sacs in vivo  

Microsoft Academic Search

Ovules of Nicotiana tabacum L. were cryofixed with a propane-jet freezer and freeze-substituted in acetone to examine technique-dependent changes in pre- and post-fertilization embryo sacs using rapidly frozen material. Freezing quality was acceptable in 10% of the embryo sacs in the partially dissected ovules, with ice-crystal damage frequently evident in vacuoles and nuclei. One of the two synergids begins to

B. Q. Huang; G. W. Strout; S. D. Russell

1993-01-01

222

SAC-CI study of the excited states of free base tetrazaporphin  

NASA Astrophysics Data System (ADS)

The SAC (symmetry adapted cluster)/SAC-CI method is applied to calculations of the ground and excited states of free base tetrazaporphin (FBTAP). The electronic spectrum is reproduced in fairly good agreement with experiments, and unknown absorption bands in the energy region higher than 4 eV are predicted. The effect of meso-tetraaza-substitution on the excited states of porphin macrocycle explains why the compound is colored, as in the closely related compounds, phthalocyanines, used as pigments.

Toyota, Kazuo; Hasegawa, Jun-ya; Nakatsuji, Hiroshi

1996-03-01

223

Retained caseous yolk sac in a Burmese python (Python molurus bivittatus).  

PubMed

Retained yolk sacs are common in the domestic chicken and account for considerable morbidity and mortality during late embryonic development and within the first 10 days of life. What is believed to be the first recorded instance of a retained caseous yolk sac and its successful surgical removal from a Burmese python (Python molurus bivittatus) is reported. The snake experienced no post-operative complications and continues to be well 16 mo following surgery. PMID:2250338

Bodri, M S; Hendrick, M J; O'Brien, R T; Sadanaga, K K

1990-10-01

224

Tumors of Peritoneum  

Microsoft Academic Search

\\u000a Primary peritoneal tumors and tumor-like conditions of secondary mullerian system include various endometrioid, serous, and\\u000a mucinous lesions. Endometriosis is the most common tumor-like condition resulting in a significant morbidity in women of reproductive\\u000a years of age. In addition, preneoplastic hyperplasia and carcinomas (clear cell and endometrioid carcinomas) may arise from\\u000a endometriosis. Primary peritoneal serous carcinoma is a frequent differential diagnosis

David Chhieng; Pei Hui

225

The Ashbya gossypii fimbrin SAC6 is required for fast polarized hyphal tip growth and endocytosis.  

PubMed

Ashbya gossypii has been an ideal system to study filamentous hyphal growth. Previously, we identified a link between polarized hyphal growth, the organization of the actin cytoskeleton and endocytosis with our analysis of the A. gossypii Wiskott-Aldrich Syndrome Protein (WASP)-homolog encoded by the AgWAL1 gene. Here, we studied the role of AgSAC6, encoding a fimbrin in polarized hyphal growth and endocytosis, and based on our functional analysis identified genetic interactions between AgSAC6 and AgWAL1. SAC6 mutants show severely reduced polarized growth. This growth phenotype is temperature dependent and sac6 spores do not germinate at elevated temperatures. Spores germinated at 30°C generate slow growing mycelia without displaying polarity establishment defects at the hyphal tip. Several phenotypic characteristics of sac6 hyphae resemble those found in wal1 mutants. First, tips of sac6 hyphae shifted to 37°C swell and produce subapical bulges. Second, actin patches are mislocalized subapically. And third, the rate of endocytotic uptake of the vital dye FM4-64 was reduced. This indicates that actin filament bundling, a conserved function of fimbrins, is required for fast polarized hyphal growth, polarity maintenance, and endocytosis in filamentous fungi. PMID:21237627

Jorde, Sigyn; Walther, Andrea; Wendland, Jürgen

2011-01-14

226

Design of the SAC-D/NIRST camera module  

NASA Astrophysics Data System (ADS)

Aquarius/SAC-D is a cooperative international mission conducted jointly by the National Aeronautics and Space Administration (NASA) of the United States of America (USA) and the Comisión Nacional de Actividades Espaciales (CONAE) of Argentina. The overall mission targets the understanding of the total Earth system and the consequences of the natural and man-made changes in the environment of the planet. Jointly developed by CONAE and the Canadian Space Agency (CSA), the New IR Sensor Technology (NIRST) instrument will monitor high temperature events on the ground related to fires and volcanic events, and will measure their physical parameters. Furthermore, NIRST will take measurements of sea surface temperatures mainly off the coast of South America as well as other targeted opportunities. NIRST has one band in the mid-wave infrared centered at 3.8 um with a bandwidth of 0.8 um, and two bands in the thermal infrared, centered respectively at 10.85 and 11.85 um with a bandwidth of 0.9 um. The temperature range is from 300 to 600 K with an NEDT < 0.5 K for the mid-infrared band and from 200 to 400 K with an NEDT < 0.4 K for the thermal bands. The baseline design of the NIRST is based on micro-bolometer technology developed jointly by INO and the CSA. Two arrays of 512x3 uncooled bolometric sensors will be used to measure brightness temperatures. The instantaneous field-of-view is 534 microradians corresponding to a ground sampling distance of 350 m at the subsatellite point. A pointing mirror allows a total swath of +/- 500 km. This paper describes the detailed design of the NIRST camera module. Key performance parameters are also presented.

Gauvin, Jonny; Châteauneuf, François; Marchese, Linda; Coté, Patrice; Leclerc, Mélanie; Chevalier, Claude; Marraco, Hugo; Phong, Linh N.

2007-10-01

227

Meiosis error and subsequent genetic and epigenetic alterations invoke the malignant transformation of germ cell tumor.  

PubMed

Germ cell tumors (GCTs) are thought to arise from primordial germ cells (PGCs) that undergo epigenetic reprogramming. To explore the mechanisms of GCT formation, we analyzed single-nucleotide polymorphism array comparative genomic hybridization patterns and the methylation status of 15 tumor suppressor genes (TSGs) and differentially methylated regions (DMRs) of two imprinted genes, H19 and SNRPN, in 28 children with GCTs. Three GCTs with 25-26 segmental uniparental disomies (UPDs), heterozygous centromeric regions, and a highly methylated SNRPN DMR may have occurred through meiosis I error. Three other GCTs with whole UPD and homozygous centromeric regions of all chromosomes may have occurred through endoreduplication of a haploid set in an ovum or testis. The other 22 GCTs had heterozygous centromeric regions of all chromosomes and no or a small number of segmental or whole UPDs and may have developed from premeiotic PGCs before imprint erasure or a reestablishment of imprinting. Gain and amplification of 3p24-p22 and 20q13-q13, and loss and UPD of 1p36-p35, 4q21-q21, 5q11-q13, and 6q26-qter were found in five or more tumors. 1p36-p35 loss was frequent, and found in 19 tumors; RUNX3 residing at 1p36 was methylated in the promoter regions of 16 tumors. Two yolk sac tumors with many segmental UPDs or whole UPD of all chromosomes had gain of 20q13-q13 and loss of 1p36-p35, and seven or eight methylated TSGs. These genetic and epigenetic alterations may have caused malignant transformation because they were rarely found in teratomas with segmental or whole UPDs. PMID:23225212

Ichikawa, Mizuho; Arai, Yasuhito; Haruta, Masayuki; Furukawa, Shinsuke; Ariga, Tadashi; Kajii, Tadashi; Kaneko, Yasuhiko

2012-12-08

228

Leiomyoma arising from septum of nose.  

PubMed

Leiomyomas are benign tumours which are presumed to arise from vascular smooth muscle in the nasal cavity. They are rare in nasal cavity but are commonly encountered in GIT, female genital tract (uterus). The rarity of these tumours in nasal cavity is evident from the fact that less than 45 cases have been reported till date. We report a 45 years old male with Leiomyoma of the nasal cavity with brief review of literature. PMID:22754842

Purohit, G N; Agarwal, Navneet; Agarwal, Ritu

2011-04-23

229

Clear Cell Adenocarcinoma Arising from Abdominal Wall Endometriosis  

PubMed Central

Endometriosis is a frequent benign disorder. Malignancy arising in extraovarian endometriosis is a rare event. A 49-year-old woman is presented with a large painful abdominal wall mass. She underwent a myomectomy, 20 years before, for uterus leiomyoma. Computed tomography suggested that this was a desmoid tumor and she underwent surgery. Histological examination showed a clear cell adenocarcinoma associated with endometriosis foci. Pelvic ultrasound, computed tomography, and endometrial curettage did not show any malignancy or endometriosis in the uterus and ovaries. Adjuvant chemotherapy was recommended, but the patient was lost to follow up. Six months later, she returned with a recurrence of the abdominal wall mass. She was given chemotherapy and then she was reoperated.

Achach, Thouraya; Rammeh, Soumaya; Trabelsi, Amel; Ltaief, Rached; Ben Abdelkrim, Soumaya; Mokni, Moncef; Korbi, Sadok

2008-01-01

230

Adenolipoma of the Skin Arising at Neck Region  

PubMed Central

We report here a case of adenolipoma of the skin, an unusual variant of lipoma, arising on the neck. A 56-year-old man visited our hospital due to an anterior neck mass. An excisional biopsy was performed. The mass revealed a tan-yellow soft cut surface. We could not find any difference from other lipoma on gross inspection. Microscopically, the mass showed proliferation of mature adipocytes admixed with several eccrine units. The eccrine units were demonstrated by periodic acid-Schiff-positive granules in the secretory portions and by positivity of smooth muscle actin in the myoepithelial cells surrounding the eccrine glands. The tumor was completely excised, and the patient has been followed up without any evidence of recurrence so far.

Song, Yoon Sang

2012-01-01

231

Sebaceous Carcinoma Arising in Mature Cystic Teratoma of Ovary  

PubMed Central

Roughly 1% of mature cystic teratomas undergo malignant transformation. In particular, cutaneous-type adnexal neoplasms may occur in mature cystic teratomas. Sebaceous carcinomas, which arise from mature cystic teratomas, have rarely been observed, with only seven cases previously reported. Here, we present a case of a 69-year-old female who had pelvic pain for two weeks and who subsequently underwent bilateral salpingo-oophorectomy and hysterectomy. Her left ovary showed a unilocular cyst, measuring 22.0 cm in diameter, filled with sebaceous material and a few hairs. A luminally-protruding solid mass measuring 4.0 cm in diameter was also noted. Microscopic findings revealed lobular or diffusely arranged basophilic, atypical sebaceous cells connected to a typical mature cystic teratoma. Tumor cells demonstrated positive immunoreactivity for high molecular weight cytokeratin, cytokeratin 7, cytokeratin 19, epithelial membrane antigen, and carcinoembryonic antigen. Here, we present a case of sebaceous carcinoma arising from a mature cystic teratoma along with a review of previously published reports.

An, Hyo Jeong; Jung, Yong Han; Yoon, Hye Kyoung

2013-01-01

232

IgG is transported across the mouse yolk sac independently of Fc?RIIb  

PubMed Central

It is generally accepted that FcRn is the major IgG transporter in human syncytiotrophoblast and the mouse yolk sac endoderm, however the finding of a different Fc receptor Fc?RIIb (RIIb) in the human placental endothelium has suggested the existence of an additional IgG transporter. To test this hypothesis in the mouse, we utilized wild-type (RIIb+/+) mice and mice with a null mutation in the gene encoding RIIb (RIIb?/? mice). We found that while RIIb is expressed in the placental yolk sac vasculature of RIIb+/+ mice, the IgG concentrations in fetuses of RIIb+/+ mice and RIIb?/?mice are not different. This result refutes the hypothesis that yolk sac RIIb is required for transport of IgG in utero in the mouse. However, the capillary bed in the mouse yolk sac is structurally more complex than in human placenta, consisting of 3 types of cells: an RIIb-negative endothelium, a unique RIIb-bearing cell that also expresses two out of four macrophage markers but not endothelial cell or pericyte markers, and pericytes. As in the human placenta the b2 isoform of RIIb predominates in the mouse yolk sac. Remarkably only a single capillary channel rather than two channels with a loop is found in each yolk sac villus, which along with intracapillary erythrocytes, suggests that blood flow is peristaltic and mediated by pericytes. It is not clear whether RIIb in the human placental villus might contribute to IgG transport function in light of our finding that the mouse yolk sac equivalent is unnecessary in this role.

Mohanty, Sudhasri; Kim, Jonghan; Ganesan, Latha P.; Phillips, Gary S.; Hua, Keding; Jarjoura, David; Hayton, William L.; Robinson, John M.; Anderson, Clark L.

2011-01-01

233

Kapteyn series arising in radiation problems  

NASA Astrophysics Data System (ADS)

In discussing radiation from multiple point charges or magnetic dipoles, moving in circles or ellipses, a variety of Kapteyn series of the second kind arises. Some of the series have been known in closed form for a hundred years or more, others appear not to be available to analytic persuasion. This paper shows how 12 such generic series can be developed to produce either closed analytic expressions or integrals that are not analytically tractable. In addition, the method presented here may be of benefit when one has other Kapteyn series of the second kind to consider, thereby providing an additional reason to consider such series anew.

Lerche, I.; Tautz, R. C.

2008-01-01

234

Pediatric spinal tumors.  

PubMed

Although tumors of the central nervous system in children constitute the second most prevalent tumor type of childhood, spinal cord tumors account for less than 10% of pediatric central nervous system tumors. The most common are intramedullary, although they can be found in the extradural compartment or as intradural extramedullary masses. Extradural tumors can arise from bony elements, the meninges, or soft tissues. Neuroblastomas and sarcomas are frequently encountered along with bone tumors. Intradural extramedullary tumors can be meningeal or from distant sites and include meningiomas and schwannomas; most tend to be benign. Intradural intramedullary tumors, neuronal or glial, can be derived from neuroepithelial tissues. For the intramedullary tumors, astrocytomas represent around 60% of tumors, ependymomas 30%, and developmental tumors 4%. Such tumors require a multidisciplinary approach to ensure optimal patient outcomes. Spinal cord tumors most often present with pain followed by motor regression, gait disturbance, sphincter dysfunction or sensory loss, torticollis, and kyphoscoliosis. Treatment is based on tumor type, but surgical resection is the mainstay. Predictors of outcome include the histological grading, extent of resection, and neurological status at the time of surgery. PMID:23622304

Hsu, Wesley; Jallo, George I

2013-01-01

235

KNApSAcK-3D: a three-dimensional structure database of plant metabolites.  

PubMed

Studies on plant metabolites have attracted significant attention in recent years. Over the past 8 years, we have constructed a unique metabolite database, called KNApSAcK, that contains information on the relationships between metabolites and their expressing organism(s). In the present paper, we introduce KNApSAcK-3D, which contains the three-dimensional (3D) structures of all of the metabolic compounds included in the original KNApSAcK database. The 3D structure for each compound was optimized using the Merck Molecular Force Field (MMFF94), and a multiobjective genetic algorithm was used to search extensively for possible conformations and locate the global minimum. The resulting set of structures may be used for docking studies to identify new and potentially unexpected binding sites for target proteins. The 3D structures may also be utilized for more qualitative studies, such as the estimation of biological activities using 3D-QSAR. The database can be accessed via a link from the KNApSAcK Family website (http://kanaya.naist.jp/KNApSAcK_Family/) or directory at http://kanaya.naist.jp/knapsack3d/. PMID:23292603

Nakamura, Kensuke; Shimura, Naoki; Otabe, Yuuki; Hirai-Morita, Aki; Nakamura, Yukiko; Ono, Naoaki; Ul-Amin, Md Altaf; Kanaya, Shigehiko

2013-01-03

236

Sac enlargement without endoleak: when and how to convert and technical considerations.  

PubMed

The primary goal of endovascular treatment of abdominal aortic aneurysms (AAA) is prevention of death from rupture. Even in the absence of an endoleak, the AAA may continue to enlarge. The pathogenesis of this phenomenon remains unclear. Therefore, surveillance after endovascular AAA treatment must include regular evaluation of aneurysm size, or even better, aneurysm volume. Aneurysm sac enlargement without an endoleak is not a benign condition. Recurrent or persistent pressurization of the AAA sac will eventually result in rupture. Besides that, continued expansion of the AAA sac can result in dilatation of the infrarenal neck and/or iliac arteries, which may threaten the integrity of proximal and distal anastomotic seals. Many centers will take a pragmatic approach in case of endotension and a growing AAA, and convert to open surgery with removal of the endograft and placement of a regular vascular graft. Direct puncture and pharmacological intervention in the cause of sac enlargement by local instillation seems logical, but has failed so far. The third option for aneurysm sac enlargement without an endoleak is laparoscopic or open fenestration of the aneurysm. Until permanent solutions for endotension and endoleaks are found, endovascular aneurysm repair will remain an imperfect long-term treatment and continued follow-up will be mandatory. PMID:15614752

van Sambeek, Marc R H M; Hendriks, Johanna M; Tseng, Larissa; van Dijk, Lukas C; van Urk, Hero

2004-12-01

237

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages.  

PubMed

Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise from hematopoietic precursors that seed the skin before birth. However, the origin of these embryonic precursors remains unclear. Using in vivo lineage tracing, we identify a first wave of yolk sac (YS)-derived primitive myeloid progenitors that seed the skin before the onset of fetal liver hematopoiesis. YS progenitors migrate to the embryo proper, including the prospective skin, where they give rise to LC precursors, and the brain rudiment, where they give rise to microglial cells. However, in contrast to microglia, which remain of YS origin throughout life, YS-derived LC precursors are largely replaced by fetal liver monocytes during late embryogenesis. Consequently, adult LCs derive predominantly from fetal liver monocyte-derived cells with a minor contribution of YS-derived cells. Altogether, we establish that adult LCs have a dual origin, bridging early embryonic and late fetal myeloid development. PMID:22565823

Hoeffel, Guillaume; Wang, Yilin; Greter, Melanie; See, Peter; Teo, Pearline; Malleret, Benoit; Leboeuf, Marylène; Low, Donovan; Oller, Guillaume; Almeida, Francisca; Choy, Sharon H Y; Grisotto, Marcos; Renia, Laurent; Conway, Simon J; Stanley, E Richard; Chan, Jerry K Y; Ng, Lai Guan; Samokhvalov, Igor M; Merad, Miriam; Ginhoux, Florent

2012-05-07

238

Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti  

PubMed Central

Here we describe preparatory techniques adapted for the study of proteins of inner ear tissues and fluids that have allowed us to apply state-of-the-art analytical techniques in spite of the minute size and anatomical complexities of this organ. Illustrative examples address unresolved issues of functional and clinical significance. First, we demonstrate how quick-freezing and freeze drying prevents artifacts that arise from sampling endolymphatic sac (ES) content in the liquid state. This set the stage for the generation of the first protein profile of the ES. Identification of crucial proteins will help elucidate mechanisms of endolymph volume regulation and pathogenesis of Meniere’s disease. Second, we show how a unique situation allowed identification of otoconial proteins by mass spectrometric analysis without prior separation and we discuss possible roles for these minor otoconins in otoconial development and prevention of degenerative diseases that affect balance. Finally, we demonstrate techniques for the precise dissection of organ of Corti and its substructures, while preserving their near normal chemical state. We extended an earlier study in which we identified a novel calcium-binding protein by IEF, oncomodulin, localized in the outer hair cells and show here the applicability of prefractionation for the screening of calcium-binding proteins of organ of Corti. These studies demonstrate how advanced preparatory and analytical techniques can be applied to studies of the inner ear.

Thalmann, Isolde; Hughes, Inna; Tong, Benton D.; Ornitz, David M.; Thalmann, Ruediger

2007-01-01

239

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages  

PubMed Central

Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise from hematopoietic precursors that seed the skin before birth. However, the origin of these embryonic precursors remains unclear. Using in vivo lineage tracing, we identify a first wave of yolk sac (YS)–derived primitive myeloid progenitors that seed the skin before the onset of fetal liver hematopoiesis. YS progenitors migrate to the embryo proper, including the prospective skin, where they give rise to LC precursors, and the brain rudiment, where they give rise to microglial cells. However, in contrast to microglia, which remain of YS origin throughout life, YS-derived LC precursors are largely replaced by fetal liver monocytes during late embryogenesis. Consequently, adult LCs derive predominantly from fetal liver monocyte-derived cells with a minor contribution of YS-derived cells. Altogether, we establish that adult LCs have a dual origin, bridging early embryonic and late fetal myeloid development.

Hoeffel, Guillaume; Wang, Yilin; Greter, Melanie; See, Peter; Teo, Pearline; Malleret, Benoit; Leboeuf, Marylene; Low, Donovan; Oller, Guillaume; Almeida, Francisca; Choy, Sharon H.Y.; Grisotto, Marcos; Renia, Laurent; Conway, Simon J.; Stanley, E. Richard; Chan, Jerry K.Y.; Ng, Lai Guan; Samokhvalov, Igor M.

2012-01-01

240

Characterization and Comparison of Five SAC-based Solder Pastes for Pb-free Reflow Soldering  

Microsoft Academic Search

Based on literature review and industry survey, five types lead-free solder pastes, namely, SAC305 (96.5%Sn-3.0%Ag-0.5%Cu), SAC387 (95.5%Sn-3.8%Ag-0.7%Cu), SACS (96.2%Sn-2.5%Ag-0.8%Cu-0.5%Sb), SCN (99.3%Sn-0.7%Cu-0.05%Ni), and SACC (96.4%Sn-3.0%Ag-0.6%Cu-0.01%Ce) are studied in this paper. The basic properties of selected Pb-free solder pastes are tested based on IPC standards. These tests include solder paste particle size analysis, measurement of melting point, solder balling test, tack test

C. H. Chen; W. Wong; J. C. C. Lo; Fubin Song; S. W. R. Lee

2007-01-01

241

A New Technique for Reduction the Phase Induced Intensity Noise in SAC-OCDMA Systems  

NASA Astrophysics Data System (ADS)

A new code for reduction the phase induced intensity noise has been presented. The new code is proposed for Spectral Amplitude-Coding Optical Code Division Multiple Accesses (SAC-OCDMA). This new code family we call it Dynamic Cyclic Shift (DCS) code. The DCS code reduced the effect of Multi Access Interference (MAI) due to it is the property of variable cross correlation. We find that the performance of the DCS code is a batter than other SAC-OCDMA codes such as; Random Diagonal (RD) code, Modified Quadratic Congruence (MQC) code and Modified Frequency Hopping (MFH) code. Through the mathematical calculation and simulation analysis, for the bit-error rate of DCS code is significantly better than other SAC-OCDMA codes, the effect of Phase Induced Intensity Noise is reduced. In addition, proofof-principle simulations of 10 Gb/s for 20 km have been successfully demonstrated and achieved low BER compared to the other codes.

Abd, Thanaa Hussein; Aljunid, Syed Alwee; Fadhil, Hilal Adnan

2011-12-01

242

Intraembryonic, but not yolk sac hematopoietic precursors, isolated before circulation, provide long-term multilineage reconstitution.  

PubMed

The relative contribution of yolk sac and intraembryonic precursors to hematopoiesis has been a matter of long-standing controversy. As reconstitution activity has so far only been found in embryonic tissues after the onset of circulation, the origin of reconstituting cells could not be formally established. Here, we separated yolk sac and intraembryonic splanchnopleura prior to circulation and maintained the explants in organ culture before transfer. Precursors derived from the intraembryonic site generated multilineage hematopoietic progeny in adult mice for more than 6 months. Yolk sac cells only provided myeloid short-term reconstitution. The results reveal a differential hematopoietic capacity of precirculation embryonic tissues in vivo, and indicate that the only cells capable of adult long-term hematopoiesis are of intraembryonic origin. PMID:11567637

Cumano, A; Ferraz, J C; Klaine, M; Di Santo, J P; Godin, I

2001-09-01

243

Deafness due to bilateral endolymphatic sac tumours in a case of von Hippel-Lindau syndrome.  

PubMed Central

A case of bilateral endolymphatic sac tumours is reported. In a patient with von Hippel-Lindau syndrome, tumour growth in the right cerebellopontine angle caused deafness. The tumour was removed and classified as a metastasis from a thyroid carcinoma. However, on thyroidectomy no primary neoplasm could be found. Eight years later a similar tumour was operated on in the left petrosal bone. Histological appearance, immunocytochemical findings, and the clinical context gave evidence that the tumours had to be reclassified as endolymphatic sac tumours--extremely rare entities. The report supports the hypothesis, suggested by the few earlier case reports, that endolymphatic sac tumours could be one of the inherent tumour manifestations in von Hippel-Lindau syndrome. Images

Kempermann, G; Neumann, H P; Scheremet, R; Volk, B; Mann, W; Gilsbach, J; Laszig, R

1996-01-01

244

Epithelioid Hemangioendothelioma: A Rare Vascular Tumor  

PubMed Central

Epithelioid hemangioendothelioma is an intermediate-grade vascular tumor arising from the vascular endothelium, which usually arises in soft tissue, and skin involvement is extremely rare. We report a case that presented with primary cutaneous tumor involving the whole limb and was present since birth.

Lakshmi, S Vidya; Prabhavathy, D; Jayakumar, S; Janaki, C; Tharini, G K

2012-01-01

245

Gliosarcoma arising from an oligodendroglioma (oligosarcoma).  

PubMed

Gliosarcoma, a biphasic tumor with both mesenchymal and glial elements, is typically considered a variant of astrocytoma (glioblastoma), WHO Grade IV. A 57-year-old man presented with altered mental status and was found to have a large right frontal mass. Biopsy and subsequent subtotal resection revealed a WHO Grade II oligodendroglioma with classic histological features, expression of IDH1 R132H mutant protein, and chromosome 1p19q co-deletion. Fifteen months later, the patient developed recurrent tumor composed of intersecting fascicles of spindled cells with necrosis and a high mitotic index. The recurrent tumor stained for both mesenchymal and glial elements, consistent with the diagnosis of gliosarcoma, and showed retained IDH1 R132H expression. By FISH analysis, the gliosarcoma showed no evidence of 1p19q co-deletion. We performed SNP arrays and detailed SNP analysis of both the oligodendroglioma and the gliosarcoma. This demonstrated loss of heterozygosity (LOH) of chromosomes 1 and 19 in the gliosarcoma with retention of the same full-length chromosomes 1 and 19 found intact in the oligodendroglioma. Not surprisingly, the gliosarcoma harbored multiple additional alterations, consistent with clonal evolution. There have been only rare reports of sarcomatous transformation of oligodendroglioma ("oligosarcoma") and most were published prior to the development of modern genetic modalities. Here we present a case with detailed genetic evidence that suggests that mesenchymal metaplasia sarcomatous transformation is possible in classic oligodendrogliomas with 1p19q codeletions. PMID:23254140

Hiniker, Annie; Hagenkord, Jill M; Powers, Martin P; Aghi, Manish K; Prados, Michael D; Perry, Arie

246

Intracranial aneurysm arising from infundibular dilation.  

PubMed

Infundibular dilations (IDs) are funnel-shaped enlargements in the origin of intracranial arteries. Usually, IDs occur at the junction between posterior communicating artery (PcomA) and internal carotid artery (ICA). Progression from an ID of the PcomA to aneurysms has been described, but is unclear whether an ID is a preaneurysmal state or a normal anatomical variant. The authors describe a 55-year-old female patient presenting multiple intracranial aneurysms with a small one arising from an ID at the level of posterior communicating segment of ICA. To the best of our knowledge, after a criterious search in the English literature, it is the first description of such unusual combination. The preoperative neurosurgical planning is discussed as well as the importance of intraoperative findings to the best management of this unusual situation. PMID:23904431

Pereira, Benedito Jamilson Araujo; Holanda, Vanessa Milanesi; de Holanda, Carlos Vanderlei Medeiros; de Oliveira, Jean Goncalves

2013-07-31

247

A mild mutator phenotype arises in a mouse model for malignancies associated with neurofibromatosis type 1.  

PubMed

Defects in genes that control DNA repair, proliferation, and apoptosis can increase genomic instability, and thus promote malignant progression. Although most tumors that arise in humans with neurofibromatosis type 1 (NF1) are benign, these individuals are at increased risk for malignant peripheral nerve sheath tumors (MPNST). To characterize additional mutations required for the development of MPNST from benign plexiform neurofibromas, we generated a mouse model for these tumors by combining targeted null mutations in Nf1 and p53, in cis. CisNf1+/-; p53+/- mice spontaneously develop PNST, and these tumors exhibit loss-of-heterozygosity at both the Nf1 and p53 loci. Because p53 has well-characterized roles in the DNA damage response, DNA repair, and apoptosis, and because DNA repair genes have been proposed to act as modifiers in NF1, we used the cisNf1+/-; p53+/- mice to determine whether a mutator phenotype arises in NF1-associated malignancies. To quantitate spontaneous mutant frequencies (MF), we crossed the Big Blue mouse, which harbors a lacI transgene, to the cisNf1+/-; p53+/- mice, and isolated genomic DNA from both tumor and normal tissues in compound heterozygotes and wild-type siblings. Many of the PNST exhibited increased mutant frequencies (MF=4.70) when compared to normal peripheral nerve and brain (MF=2.09); mutations occurred throughout the entire lacI gene, and included base substitutions, insertions, and deletions. Moreover, the brains, spleens, and livers of these cisNf1+/-; p53+/- animals exhibited increased mutant frequencies when compared to tissues from wild-type littermates. We conclude that a mild mutator phenotype arises in the tumors and tissues of cisNf1+/-; p53+/- mice, and propose that genomic instability influences NF1 tumor progression and disease severity. PMID:17208258

Garza, Rene; Hudson, Robert A; McMahan, C Alex; Walter, Christi A; Vogel, Kristine S

2007-02-01

248

INCIDENCE AND SIZE DISTRIBUTION OF UNABSORBED YOLK SACS IN COMMERCIAL BROILERS PROCESSED AT SIX WEEKS OF AGE  

Technology Transfer Automated Retrieval System (TEKTRAN)

Unabsorbed yolk sacs are being investigated as a possible vehicle for vertical transmission of Campylobacter and salmonellae from broiler breeder hens to broilers. However, it is unknown at what frequency unabsorbed yolk sacs exist in present day commercial broilers at the time of processing. Two ...

249

The fine structure of the maxillary gland of the brine shrimp, Artemia salina : The end-sac  

Microsoft Academic Search

The gross morphology of the maxillary gland of the adult brine shrimp, Artemia salina, was studied by light microscopy, and some features of Warren's (1938) original description of the gland were confirmed. Each gland consists of two parts: an end-sac and an efferent excretory duct. The end-sac is centrally located, and around it the efferent duct coils, making three loops

Greta E. Tyson

1968-01-01

250

Can tumor cell suspension serve as an optical model of tumor tissue in situ?  

NASA Astrophysics Data System (ADS)

We determined and compared to the optical properties of five samples obtained from xenotransplanted chick embryos chorio- allantoic membrane tumors, five samples obtained from xenotransplanted chick embryos yolk sac membrane tumors, and five samples of concentrated tumor cells suspension (small cell lung carcinoma OAT 75). The absorption coefficient (mu) a, the scattering coefficient (mu) s, the anisotropy factor g, and the reduced scattering coefficient (mu) s' were evaluated in the spectral range from 600 nm to 900 nm with a step width of 10 nm from double integrating sphere measurements using an inverse Monte Carlo technique. The results have shown that the optical properties of the concentrated tumor cell suspension are similar to those of the chorio-allantoic membrane tumor, but are essentially different from the optical properties of the yolk sac membrane tumor. Cell vitality tests have shown that the cells were alive during and after the experiments. Therefore, the tumor cell suspension can serve as an optical model of the chorio-allantoic membrane tumor in situ for testing and developing novel diagnostic and therapeutic techniques.

Yaroslavsky, Anna N.; Vervoorts, Anja; Priezzhev, Alexander V.; Yaroslavsky, I. V.; Moser, Joerg G.; Schwarzmaier, Hans-Joachim

1999-01-01

251

Effects of granulation on organic acid metabolism and its relation to mineral elements in Citrus grandis juice sacs.  

PubMed

We investigated the effects of granulation on organic acid metabolism and its relation to mineral elements in 'Guanximiyou' pummelo (Citrus grandis) juice sacs. Granulated juice sacs had decreased concentrations of citrate and isocitrate, thus lowering juice sac acidity. By contrast, malate concentration was higher in granulated juice sacs than in normal ones. The reduction in citrate concentration might be caused by increased degradation, as indicated by enhanced aconitase activity, whilst the increase in malate concentration might be caused by increased biosynthesis, as indicated by enhanced phosphoenolpyruvate carboxylase (PEPC). Real time quantitative reverse transcription PCR (qRT-PCR) analysis showed that the activities of most acid-metabolizing enzymes were regulated at the transcriptional level, whilst post-translational modifications might influence the PEPC activity. Granulation led to increased accumulation of mineral elements (especially phosphorus, magnesium, sulphur, zinc and copper) in juice sacs, which might be involved in the incidence of granulation in pummelo fruits. PMID:24128573

Wang, Xian-You; Wang, Ping; Qi, Yi-Ping; Zhou, Chen-Ping; Yang, Lin-Tong; Liao, Xin-Yan; Wang, Liu-Qing; Zhu, Dong-Huang; Chen, Li-Song

2013-09-11

252

An organism arises from every nucleus.  

PubMed

The fact that, cloning using somatic cell nuclear transfer (SCNT) method has been performed, opened new horizons for cloning, and changed the way of our understanding and approach to cell and nucleus. The progress in cloning technology, brought the anticipation of the ability to clone an organism from each somatic cell nucleus. Therefore, the 'Cell Theory' is about to take the additional statement as "An organism arises from every nucleus". The development of gene targeting procedures which can be applied with SCNT, showed us that it may be possible to obtain different versions of the original genetic constitution of a cell. Because of this opportunity which is provided by SCNT, in reproductive cloning, it would be possible to clone enhanced organisms which can adapt to different environmental conditions and survive. Furthermore, regaining the genetic characteristics of ancestors or reverse herediter variations would be possible. On the other hand, in therapeutic cloning, more precise and easily obtainable alternatives for cell replacement therapy could be presented. However, while producing healthier or different organisms from a nucleus, it is hard to foresee the side effects influencing natural processes in long term is rather difficult. PMID:19995701

Keklikoglu, Nurullah

2009-01-01

253

Multiple large cysts arising from nevus comedonicus.  

PubMed

Nevus comedonicus is a type of hamartoma that arises from a developmental anomaly of the mesodermal part of the pilosebaceous gland. In most cases of nevus comedonicus, an acne-like skin condition develops. Repeated inflammation can cause a morphological change to the cyst, papule, to abscess. We experienced a case of congenital nevus comedonicus, which led to the formation of large multiple cysts. A 50-year-old man was referred with a 12.5×10 cm lobulated mass on the posterior neck and upper back. The patient had a widespread presence of nevus comedonicus in the region ranging from the right superior chest to the posterior neck. The patient had a 30-year history of six prior excisions. A magnetic resonance imaging review led to a diagnosis of nevus comedonicus. Surgical treatment consisted of excision of the mass and wide excision for the patch type of nevus comedonicus around the neck. On histopathology, multiple masses were diagnosed as typical cysts containing keratinized tissue. The diffuse comedone lesions were diagnosed as nevus comedonicus. This case shows that large, multiple cysts can occur as a long-term complication of nevus comedonicus, and also highlights the importance of radical resection to prevent its further invagination. PMID:22783495

Jeong, Hii-Sun; Lee, Hye-Kyung; Lee, Seung-Hyun; Kim, Hyoung-Suk; Yi, Sang-Yeop

2012-01-15

254

Primacy and Recency as Factors in Cul-de-Sac Elimination in a Stylus Maze  

Microsoft Academic Search

For this experiment a form of maze was used which was sufficiently difficult for the human subject and involved only a single type of cul-de-sac. Two patterns of the maze were constructed, the only difference in the two being that one was a lateral reversal of the other. Sixty subjects took part in the experiment. The results support the view,

C. J. Warden

1924-01-01

255

The South China Sea, a cul-de-sac of North Pacific Intermediate Water  

Microsoft Academic Search

This study discusses branching of the Kuroshio Current including North Pacific Intermediate Water (NPIW) into the South China Sea (SCS). The spreading path of the subtropical salinity minimum of NPIW is southwestward pointing to the Luzon Strait between Taiwan and Luzon islands. Using a large collection of updated hydrography, results show that the SCS is a cul-de-sac for the subtropical

Yuzhu You; Ching-Sheng Chern; Yih Yang; Cho-Teng Liu; Kon-Kee Liu; Su-Cheng Pai

2005-01-01

256

Cul-de-sac Packing with a Metreurynter in Gasless Laparoscopic Cystectomy during Pregnancy  

Microsoft Academic Search

Gasless laparoscopic cystectomy was performed for a woman in the fifteenth week of pregnancy. An ovarian cyst that had been sinking behind the uterus appeared spontaneously after ballooning the metreurynter in the pouch of Douglas. This allowed extraperitoneal cystectomy, and the patient's subsequent antenatal course was uneventful. Cul-de-sac packing with a metreurynter permits gentle and atraumatic manipulation against the pregnant

Takashi Murakami; Takahiro Noda; Chikako Okamura; Yukihiro Terada; Yuki Morito; Kunihiro Okamura

2003-01-01

257

Successful separation of the conjoined thecal sac with an epidermal cyst in pygopagus twins.  

PubMed

Pygopagus conjoined twins are very rare, and half of all pygopagus twins have other anomalies. This report describes the successful surgical separation of pygopagus twins who had a conjoined thecal sac and an epidermal cyst. Meticulous preoperative planning, development of a model simulator, multispecialty teamwork, and a staged surgery contributed to a successful outcome. PMID:21929972

Chou, Yu-Cheng; Peng, Hai-Chyi; Chu, Chia-Hsiang; Tsai, Sheng-Tzung; Ling, Joseph Chang Ming; Hsu, Yung-Hsiang; Chen, Shin-Yuan; Harnod, Tomor

2011-09-01

258

Laparoscopy through the open ipsilateral sac to evaluate presence of contralateral hernia  

Microsoft Academic Search

Purpose: Laparoscopic evaluation of the contralateral side (LECS) in children with unilateral inguinal hernia (UIH) has been criticized because of the abdominal trocar risk and costs. LECS was modified to avoid abdominal trocar insertion by using the open hernia sac for instrumentation (OHLECS). This study was performed to determine the utility, safety, and effectiveness of this technique. Methods: During a

Mark L. Wulkan; Eugene S. Wiener; Nancy VanBalen; Peter Vescio

1996-01-01

259

In vitro sugar uptake by grapefruit ( Citrus paradisi ) juice-sac cells  

Microsoft Academic Search

To further our understanding of the mechanisms of sugar uptake and accumulation into grapefruit (Citrus paradisi Macf. cv. Marsh seedless), the patterns of uptake and utilisation of sucrose, glucose and fructose by Citrus juice cells was investigated. Analyses were conducted on sliced juice sacs that were incubated in radioactive (14C)-sugar solutions with unlabelled sugars, in the presence or absence of

Moshe HubermanA; Uri Zehavi; Wilfred D. Stein; Ed Etxeberria; Raphael Goren

2005-01-01

260

Mutations in the Saccharomyces cerevisiae gene SAC1 cause multiple drug sensitivity.  

PubMed

Wild-type yeast Saccharomyces cerevisiae are surprisingly resistant to a wide range of drugs and agents. We had previously isolated novobiocin-sensitive mutants to aid the study of the intracellular target for this drug. Characterization of one of these mutants, mds1, revealed that it was sensitive not only to novobiocin but also to a wide range of drugs. The nature of this multiple drug-sensitive phenotype was shown to be different from that of previously isolated multiple drug-sensitive mutants. We have shown that the multiple drug-sensitivity of mds1 is due to mutations within the gene SAC1 and have identified a variety of mutations within the gene from the Mds1 strain. SAC1 encodes a protein which has been previously implicated in the correct function of the actin cytoskeleton, in inositol metabolism, in ATP transport in the endoplasmic reticulum and in Sec14p (PI-TP) function. We have shown that multiple drug-sensitivity is a new phenotype seen in some, but not all, of the previously characterized sac1 mutants. Based on our findings, we propose a mechanism by which Sac1p could affect drug resistance and also mediate other effects on cell growth. PMID:10455234

Hughes, W E; Pocklington, M J; Orr, E; Paddon, C J

1999-08-01

261

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.  

PubMed Central

The scl gene encodes a basic-helix-loop-helix transcription factor which was identified through its involvement in chromosomal translocations in T-cell leukemia. To elucidate its physiological role, scl was targeted in embryonic stem cells. Mice heterozygous for the scl null mutation were intercrossed and their offspring were genotyped. Homozygous mutant (scl-/-) pups were not detected in newborn litters, and analysis at earlier time points demonstrated that scl-/- embryos were dying around embryonic day 9.5. The scl-/- embryos were pale, edematous, and markedly growth retarded after embryonic day 8.75. Histological studies showed complete absence of recognizable hematopoiesis in the yolk sac of these embryos. Early organogenesis appeared to be otherwise normal. Culture of yolk sac cells of wild-type, heterozygous, and homozygous littermates confirmed the absence of hematopoietic cells in scl-/- yolk sacs. Reverse transcription PCR was used to examine the transcripts of several genes implicated in early hematopoiesis. Transcripts of GATA-1 and PU.1 transcription factors were absent from RNA from scl-/- yolk sacs and embryos. These results implicate scl as a crucial regulator of early hematopoiesis. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4

Robb, L; Lyons, I; Li, R; Hartley, L; Kontgen, F; Harvey, R P; Metcalf, D; Begley, C G

1995-01-01

262

Ventilation patterns of the songbird lung/air sac system during different behaviors.  

PubMed

Unidirectional, continuous airflow through the avian lung is achieved through an elaborate air sac system with a sequential, posterior to anterior ventilation pattern. This classical model was established through various approaches spanning passively ventilated systems to mass spectrometry analysis of tracer gas flow into various air sacs during spontaneous breathing in restrained ducks. Information on flow patterns in other bird taxa is missing, and these techniques do not permit direct tests of whether the basic flow pattern can change during different behaviors. Here we use thermistors implanted into various locations of the respiratory system to detect small pulses of tracer gas (helium) to reconstruct airflow patterns in quietly breathing and behaving (calling, wing flapping) songbirds (zebra finch and yellow-headed blackbird). The results illustrate that the basic pattern of airflow in these two species is largely consistent with the model. However, two notable differences emerged. First, some tracer gas arrived in the anterior set of air sacs during the inspiration during which it was inhaled, suggesting a more rapid throughput through the lung than previously assumed. Second, differences in ventilation between the two anterior air sacs emerged during calling and wing flapping, indicating that adjustments in the flow pattern occur during dynamic behaviors. It is unclear whether this modulation in ventilation pattern is passive or active. This technique for studying ventilation patterns during dynamic behaviors proves useful for establishing detailed timing of airflow and modulation of ventilation in the avian respiratory system. PMID:23788706

Mackelprang, Rebecca; Goller, Franz

2013-06-20

263

SAC-CI methodology applied to molecular spectroscopy and photo-biology  

NASA Astrophysics Data System (ADS)

The SAC-CI method was applied to the spectroscopy of radical cations and anions of various organic molecules. It was also applied to photo-biology, in particular, to elucidate the bio-molecular color-tuning mechanism of human visions and to the circular dichroism spectroscopy that is used to understand the helical structures of DNA and RNA.

Hasegawa, J.; Miyahara, T.; Nakashima, H.; Nakatsuji, H.

2012-06-01

264

INCIDENCE AND MICROBIOLOGY OF UNABSORBED YOLK SACS (ATTACHED OR FREE FLOATING) IN COMMERICAL BROILERS  

Technology Transfer Automated Retrieval System (TEKTRAN)

In the developing avian embryo, the main energy source is yolk. Towards the end of the incubation period, the remaining yolk sac is internalized into the abdominal cavity. At hatch, yolk comprises 20% of the chick’s body weight and provides the nutrients for growth. The yolk should be depleted an...

265

Food Habit Study of Striped Bass Post Yolk-Sac Larvae.  

National Technical Information Service (NTIS)

Striped bass post yolk-sac larvae and zooplankton were sampled simultaneously during May, 1977 at three locations near the mouth of the Sassafras River in Upper Chesapeake Bay. Diel variations in post-larval stomach content volume during five 24-hour stud...

P. E. Miller

1978-01-01

266

Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor.  

PubMed

The case of a woman who developed a cervical sarcoma botryoides tumor at age 14 years and a right ovarian Sertoli-Leydig cell tumor with alpha-fetoprotein production at 27 years is presented. The sarcoma botryoides was a stage 1b, 4-cm, polypoid ectocervical tumor treated by radical hysterectomy and bilateral pelvic lymphadenectomy. The Sertoli-Leydig cell tumor was a stage 1a, 145-g mass removed piecemeal by right oophorectomy. Histologically, it was an intermediate Sertoli-Leydig cell tumor with a heterologous element composed of an endometrioid-like yolk sac tumor which was producing alpha-fetoprotein. There was no histological similarity between the two tumors. The patient is alive without evidence of disease, 16 years after diagnosis of her sarcoma botryoides and 3 years after her Sertoli-Leydig cell tumor. This is, to our knowledge, the third known association between these two rare gynecological tumors. The basis of the association remains unknown. PMID:9345364

Golbang, P; Khan, A; Scurry, J; MacIsaac, I; Planner, R

1997-10-01

267

Electromigration effect on intermetallic growth and Young's modulus in SAC solder joint  

NASA Astrophysics Data System (ADS)

Solid-state intermetallic compound (IMC) growth behavior plays and important role in solder joint reliability of electronic packaging assemblies. The directional impact of electromigration (EM) on the growth of interfacial IMCs in Ni/SAC/Ni, Cu/SAC/Ni single BGA ball solder joint, and fine pitch ball-grid-array (FPBGA) at the anode and cathode sides is reported in this study. When the solder joint was subjected to a current density of 5,000 A/cm2 at 125°C or 150°C, IMC layer growth on the anode interface was faster than that on the cathode interface, and both were faster than isothermal aging due to the Joule heating effect. The EM affects the IMC growth rate, as well as the composition and mechanical properties. The Young’s modulus and hardness were measured by the nanoindentation continuous stiffness measurement (CSM) from planar IMC surfaces after EM exposure. Different values were observed at the anode and cathode. The energy-dispersive x-ray (EDX) line scan analysis was conducted at the interface from the cathode to anode to study the presence of species; Ni was found in the anode IMC at SAC/Cu in the Ni/SAC/Cu joint, but not detected when the current was reverse. Electron-probe microanalysis (EPMA) measurement on the Ni/SAC/Ni specimen also confirmed the polarized Ni and Cu distributions in cathode and anode IMCs, which were (Ni0.57Cu0.43)3Sn4 and (Cu0.73Ni0.27)6Sn5, respectively. Thus, the Young’s moduli of the IMC are 141 and 175 GPa, respectively.

Xu, Luhua; Pang, John H. L.; Ren, Fei; Tu, K. N.

2006-12-01

268

Desmoplastic medulloblastoma arising from an ovarian teratoma: a case report and review of the literature.  

PubMed

The primary neuroectodermal tumor of the ovary is extremely rare, and it manifests in 3 forms: differentiated, primitive, and anaplastic. The medulloblastoma belongs to the subgroup of primitive neuroectodermal tumor of the ovary. Only 3 cases of ovarian medulloblastoma have been reported in the literature, and all of them are presented without information about the specific pathological subtype. We present the fourth case of a 26-year-old woman who presented with abdominal fullness for months. Ultrasound exam showed a right adnexal mass with cystic feature and foci solid components. A partial oophorectomy was performed, and the mass was a desmoplastic medulloblastoma arising from an ovarian teratoma. PMID:23129837

Wey, Shiuan-Li; Chen, Chi-Kuan; Chen, Tze-Chien; Chen, Tung-Ying

2012-11-04

269

Successful Endoscopic Resection of Large Pedunculated Brunner's Gland Hamartoma Causing Gastrointestinal Bleeding Arising from the Pylorus.  

PubMed

Brunner's gland hamartoma is a rare benign small bowel neoplasm and most lesions are small and asymptomatic. However, large hamartoma-related obstructive symptoms and hemorrhage related to tumor ulceration manifest as hematemesis or melena. The exact pathogenesis if these lesions is not well known, but they are thought to be frequently associated with Helicobacter pylori infections and chronic pancreatitis. We report the case of a 45-year-old man who presented with melena due to a large pedunculated Brunner's gland hamartoma arising from the pylorus. It was successfully removed by endoscopic mucosal resection with piecemeal technique because of too large tumor size for application of a conventional snare. PMID:23904842

Jung, Yunho; Chung, Il Kwun; Lee, Tae Hoon; Cho, Young Sin; Jo, Yeong Geol; Park, Sang Heum; Cho, Hyundeuk; Kim, Sun Joo

2013-07-18

270

A Single Bivalent Efficiently Inhibits Cyclin B1 Degradation and Polar Body Extrusion in Mouse Oocytes Indicating Robust SAC during Female Meiosis I  

PubMed Central

The Spindle Assembly Checkpoint (SAC) inhibits anaphase until microtubule-to-kinetochore attachments are formed, thus securing correct chromosome separation and preventing aneuploidy. Whereas in mitosis even a single unattached chromosome keeps the SAC active, the high incidence of aneuploidy related to maternal meiotic errors raises a concern about the lower efficiency of SAC in oocytes. Recently it was suggested that in mouse oocytes, contrary to somatic cells, not a single chromosome but a critical mass of chromosomes triggers efficient SAC pointing to the necessity of evaluating the robustness of SAC in oocytes. Two types of errors in chromosome segregation upon meiosis I related to SAC were envisaged: (1) SAC escape, when kinetochores emit SAC-activating signal unable to stop anaphase I; and (2) SAC deceive, when kinetochores do not emit the signal. Using micromanipulations and live imaging of the first polar body extrusion, as well as the dynamics of cyclin B1 degradation, here we show that in mouse oocytes a single bivalent keeps the SAC active. This is the first direct evaluation of SAC efficiency in mouse oocytes, which provides strong evidence that the robustness of SAC in mammalian oocytes is comparable to other cell types. Our data do not contradict the hypothesis of the critical mass of chromosomes necessary for SAC activation, but suggest that the same rule may govern SAC activity also in other cell types. We postulate that the innate susceptibility of oocytes to errors in chromosome segregation during the first meiotic division may not be caused by lower efficiency of SAC itself, but could be linked to high critical chromosome mass necessary to keep SAC active in oocyte of large size.

Hoffmann, Steffen; Maro, Bernard; Kubiak, Jacek Z.; Polanski, Zbigniew

2011-01-01

271

A single bivalent efficiently inhibits cyclin B1 degradation and polar body extrusion in mouse oocytes indicating robust SAC during female meiosis I.  

PubMed

The Spindle Assembly Checkpoint (SAC) inhibits anaphase until microtubule-to-kinetochore attachments are formed, thus securing correct chromosome separation and preventing aneuploidy. Whereas in mitosis even a single unattached chromosome keeps the SAC active, the high incidence of aneuploidy related to maternal meiotic errors raises a concern about the lower efficiency of SAC in oocytes. Recently it was suggested that in mouse oocytes, contrary to somatic cells, not a single chromosome but a critical mass of chromosomes triggers efficient SAC pointing to the necessity of evaluating the robustness of SAC in oocytes. Two types of errors in chromosome segregation upon meiosis I related to SAC were envisaged: (1) SAC escape, when kinetochores emit SAC-activating signal unable to stop anaphase I; and (2) SAC deceive, when kinetochores do not emit the signal. Using micromanipulations and live imaging of the first polar body extrusion, as well as the dynamics of cyclin B1 degradation, here we show that in mouse oocytes a single bivalent keeps the SAC active. This is the first direct evaluation of SAC efficiency in mouse oocytes, which provides strong evidence that the robustness of SAC in mammalian oocytes is comparable to other cell types. Our data do not contradict the hypothesis of the critical mass of chromosomes necessary for SAC activation, but suggest that the same rule may govern SAC activity also in other cell types. We postulate that the innate susceptibility of oocytes to errors in chromosome segregation during the first meiotic division may not be caused by lower efficiency of SAC itself, but could be linked to high critical chromosome mass necessary to keep SAC active in oocyte of large size. PMID:22125605

Hoffmann, Steffen; Maro, Bernard; Kubiak, Jacek Z; Polanski, Zbigniew

2011-11-18

272

Bone tumor  

MedlinePLUS

Tumor - bone; Bone cancer; Primary bone tumor; Secondard bone tumor ... malignant) bone tumors include: Chondrosarcoma Ewing's sarcoma Fibrosarcoma Osteosarcomas The cancers that most often spread to the ...

273

Anaplastic Carcinoma of the Thyroid Arising More Often from Follicular Carcinoma than Papillary Carcinoma  

Microsoft Academic Search

Background  Anaplastic thyroid carcinoma (ATC), a rare and highly malignant tumor, has long been thought to arise from well-differentiated\\u000a carcinoma (WDC) such as follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC). The purpose of this study\\u000a was to test this notion by examining whether and, if so, how often ATC harbors the oncogenes that are commonly associated\\u000a with WDC, such

Hwei-Ming Wang; Yu-Wen Huang; Jen-Seng Huang; Cheng-Hsu Wang; Victor C. Kok; Chao-Ming Hung; Han-Ming Chen; Chin-Yuan Tzen

2007-01-01

274

Basal cell carcinoma arising from xeroderma pigmentosum: a case report and an immunohistochemical study.  

PubMed

We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163(+) M2 macrophages, together with Foxp3(+) regulatory T cells. Interestingly, MMP9, which was reported as one of the functional markers for immunosuppressive macrophages, was also detected in the CD163(+) M2 macrophage-infiltrated areas. Our case suggests the immunological background of tumor development in a patient with XP. PMID:23626541

Furudate, Sadanori; Fujimura, Taku; Tojo, Gen-Ichi; Haga, Takahiro; Aiba, Setsuya

2013-03-09

275

Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study  

PubMed Central

We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163+ M2 macrophages, together with Foxp3+ regulatory T cells. Interestingly, MMP9, which was reported as one of the functional markers for immunosuppressive macrophages, was also detected in the CD163+ M2 macrophage-infiltrated areas. Our case suggests the immunological background of tumor development in a patient with XP.

Furudate, Sadanori; Fujimura, Taku; Tojo, Gen-ichi; Haga, Takahiro; Aiba, Setsuya

2013-01-01

276

A Single Bivalent Efficiently Inhibits Cyclin B1 Degradation and Polar Body Extrusion in Mouse Oocytes Indicating Robust SAC during Female Meiosis I  

Microsoft Academic Search

The Spindle Assembly Checkpoint (SAC) inhibits anaphase until microtubule-to-kinetochore attachments are formed, thus securing correct chromosome separation and preventing aneuploidy. Whereas in mitosis even a single unattached chromosome keeps the SAC active, the high incidence of aneuploidy related to maternal meiotic errors raises a concern about the lower efficiency of SAC in oocytes. Recently it was suggested that in mouse

Steffen Hoffmann; Bernard Maro; Jacek Z. Kubiak; Zbigniew Polanski

2011-01-01

277

In vitro differentiation of B cells and myeloid cells from the early mouse embryo and its extraembryonic yolk sac.  

PubMed

The yolk sac is the first site of hematopoiesis during ontogeny. However, the source of early embryonic hematopoietic stem cells remains unresolved. Early studies have shown that cells obtained from day-8 and -9 extraembryonic yolk sacs can give rise to T cells and myeloid cells, whereas the embryo itself appears to lack such cells. Controversy remains as to whether it is the embryo itself or the extraembryonic yolk sac that contains the initial precursors capable of differentiating into B cells. This study used the approach of enriching hematopoietic stem cells by immunocytoadherence and studying cells isolated from within the embryo itself or from the yolk sac obtained at days 8 and 9 of mouse embryonic development. We report that on day 9, both yolk sac-derived and embryo-derived cells can give rise to B cells and myeloid cells in vitro. On day 8, however, cells isolated from the yolk sac but not from the embryo produce myeloid colonies in vitro; neither source of stem cells generates B cells. Our study suggests that myeloid precursors migrate from yolk sac to embryo earlier than has previously been reported but that the origin for B cell precursors remains to be determined. PMID:8282055

Huang, H; Zettergren, L D; Auerbach, R

1994-01-01

278

Visceral Endoderm Expression of Yin-Yang1 (YY1) Is Required for VEGFA Maintenance and Yolk Sac Development  

PubMed Central

Mouse embryos lacking the polycomb group gene member Yin-Yang1 (YY1) die during the peri-implantation stage. To assess the post-gastrulation role of YY1, a conditional knock-out (cKO) strategy was used to delete YY1 from the visceral endoderm of the yolk sac and the definitive endoderm of the embryo. cKO embryos display profound yolk sac defects at 9.5 days post coitum (dpc), including disrupted angiogenesis in mesoderm derivatives and altered epithelial characteristics in the visceral endoderm. Significant changes in both cell death and proliferation were confined to the YY1-expressing yolk sac mesoderm indicating that loss of YY1 in the visceral endoderm causes defects in the adjacent yolk sac mesoderm. Production of Vascular Endothelial Growth Factor A (VEGFA) by the visceral endoderm is essential for normal growth and development of the yolk sac vasculature. Reduced levels of VEGFA are observed in the cKO yolk sac, suggesting a cause for the angiogenesis defects. Ex vivo culture with exogenous VEGF not only rescued angiogenesis and apoptosis in the cKO yolk sac mesoderm, but also restored the epithelial defects observed in the cKO visceral endoderm. Intriguingly, blocking the activity of the mesoderm-localized VEGF receptor, FLK1, recapitulates both the mesoderm and visceral endoderm defects observed in the cKO yolk sac. Taken together, these results demonstrate that YY1 is responsible for maintaining VEGF in the developing visceral endoderm and that a VEGF-responsive paracrine signal, originating in the yolk sac mesoderm, is required to promote normal visceral endoderm development.

Rhee, Siyeon; Guerrero-Zayas, Mara-Isel; Wallingford, Mary C.; Ortiz-Pineda, Pablo; Mager, Jesse; Tremblay, Kimberly D.

2013-01-01

279

Mathematical problems arising in interfacial electrohydrodynamics  

NASA Astrophysics Data System (ADS)

In this work we consider the nonlinear stability of thin films in the presence of electric fields. We study a perfectly conducting thin film flow down an inclined plane in the presence of an electric field which is uniform in its undisturbed state, and normal to the plate at infinity. In addition, the effect of normal electric fields on films lying above, or hanging from, horizontal substrates is considered. Systematic asymptotic expansions are used to derive fully nonlinear long wave model equations for the scaled interface motion and corresponding flow fields. For the case of an inclined plane, higher order terms are need to be retained to regularize the problem in the sense that the long wave approximation remains valid for long times. For the case of a horizontal plane the fully nonlinear evolution equation which is derived at the leading order, is asymptotically correct and no regularization procedure is required. In both physical situations, the effect of the electric field is to introduce a non-local term which arises from the potential region above the liquid film, and enters through the electric Maxwell stresses at the interface. This term is always linearly destabilizing and produces growth rates proportional to the cubic power of the wavenumber - surface tension is included and provides a short wavelength cut-off, that is, all sufficiently short waves are linearly stable. For the case of film flow down an inclined plane, the fully nonlinear equation can produce singular solutions (for certain parameter values) after a finite time, even in the absence of an electric field. This difficulty is avoided at smaller amplitudes where the weakly nonlinear evolution is governed by an extension of the Kuramoto-Sivashinsky (KS) equation. Global existence and uniqueness results are proved, and refined estimates of the radius of the absorbing ball in L2 are obtained in terms of the parameters of the equations for a generalized class of modified KS equations. The established estimates are compared with numerical solutions of the equations which in turn suggest an optimal upper bound for the radius of the absorbing ball. A scaling argument is used to explain this, and a general conjecture is made based on extensive computations. We also carry out a complete study of the nonlinear behavior of competing physical mechanisms: long wave instability above a critical Reynolds number, short wave damping due to surface tension and intermediate growth due to the electric field. Through a combination of analysis and extensive numerical experiments, we elucidate parameter regimes that support non-uniform travelling waves, time-periodic travelling waves and complex nonlinear dynamics including chaotic interfacial oscillations. It is established that a sufficiently high electric field will drive the system to chaotic oscillations, even when the Reynolds number is smaller than the critical value below which the non-electrified problem is linearly stable. A particular case of this is Stokes flow, which is known to be stable for this class of problems (an analogous statement holds for horizontally supported films also). Our theoretical results indicate that such highly stable flows can be rendered unstable by using electric fields. This opens the way for possible heat and mass transfer applications which can benefit significantly from interfacial oscillations and interfacial turbulence. For the case of a horizontal plane, a weakly nonlinear theory is not possible due to the absence of the shear flow generated by the gravitational force along the plate when the latter is inclined. We study the fully nonlinear equation, which in this case is asymptotically correct and is obtained at the leading order. The model equation describes both overlying and hanging films - in the former case gravity is stabilizing while in the latter it is destabilizing. The numerical and theoretical analysis of the fully nonlinear evolution is complicated by the fact that the coefficients of the highest order terms (surface tension in this instance) are nonlinear. We i

Tseluiko, Dmitri

280

Tumor angiogenesis: molecular pathways and therapeutic targets  

Microsoft Academic Search

As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated angiogenesis is a promising tactic in limiting cancer progression. The tumor microenvironment comprises numerous signaling molecules and pathways that influence the angiogenic response. Understanding how these components functionally interact as angiogenic stimuli or as repressors and how mechanisms of resistance arise is required for the identification of new therapeutic

Sara M Weis; David A Cheresh

2011-01-01

281

CHAMP and SAC-C studies of gravity waves during stratospheric warming events  

NASA Astrophysics Data System (ADS)

We present a study of gravity wave response to major mid-winter stratospheric warmings The investigation is carried out by using the GPS radio occultation data collected by the CHAMP and SAC-C satellites The analyzed CHAMP database covers a period of 56 months starting from May 2001 to December 2005 and the SAC-C data are for the period July 2001 to December 2004 We have identified the periods of major warmings during the corresponding winter periods in the Northern Hemisphere It is found that during major warming periods the temperature is increased by an additional 25-30 K During the warming conditions the gravity wave energy Ep is observed to increase by 2-3 times larger than that during the normal period We will also describe the other characteristics of gravity waves and their response to the warming events

Namboothiri, S. P.; Kishore, P.; Igarashi, K.; Jiang, J. H.; Ao, Chi O.; Romans, Larry

282

Papillary neoplasm of the endolymphatic sac in a patient with von Hippel-Lindau disease.  

PubMed Central

Glandular tumours involving the middle ear and the mastoid are rare, and distinguishing between adenoma and adenocarcinoma is difficult. Two distinct histopathological patterns are accepted. While their clinical presentation differs, both require primary surgical treatment and both have a high rate of local recurrence. The papillary form takes a more aggressive course and wider regional spread. This pattern occurs predominantly in women. Its microscopic appearance and clinical course have been extensively described by Heffner who considered it as "low-grade adenocarcinoma of probable endolymphatic sac origin". A few cases have been associated with von Hippel-Lindau disease. The case of a 32 year old black woman is described. It is suggested that papillary adenocarcinoma of the endolymphatic sac should be considered in the spectrum of neoplasms seen in von Hippel-Lindau disease. Images

Delisle, M B; Uro, E; Rouquette, I; Yardeni, E; Rumeau, J L

1994-01-01

283

Synthesis of Cul-De-Sac Filter Networks Utilizing Hybrid Couplers  

Microsoft Academic Search

A synthesis procedure is described for the design of Cul-De-Sac networks realizing either bandpass or bandstop filter characteristics. The prototypes comprise a pair of one-port ladder sub-networks each connected at one of the coupled ports of a 3-dB, 90deg or 180deg hybrid coupler. Numerical examples and simulated filter layouts are presented to illustrate the design methodology

Wael M. Fathelbab

2007-01-01

284

Isolated fluid in the cul-de-sac: How well does it predict ectopic pregnancy?  

Microsoft Academic Search

We examined the risk of ectopic pregnancy among patients with isolated abnormal cul-de-sac fluid at transvaginal ultrasound. We conducted a retrospective cohort study of all ED patients presenting January 1995 to August 1999 with abdominal pain or vaginal bleeding and a positive [beta ]-hCG test. The risk of ectopic pregnancy in patients with a moderate volume of anechoic fluid was

Robert Dart; Samuel A. McLean; Linda Dart

2002-01-01

285

AUTORADIOGRAPHIC STUDY OF SUGAR AND AMINO ACID ABSORPTION BY EVERTED SACS OF HAMSTER INTESTINE  

Microsoft Academic Search

Autoradiographs were prepared from frozen sections of evcrted sacs of hamster jejunum which had been incubated in vitro with C 14- or H~-labcled sugars and amino acids. When such tissue was incubated in 1 mM solutions of L-valine or L-methionine, columnar absorp- tivc cells at tips of villi accumulated these amino acids to conccntrations ranging from 5 to 50 millimoles

WILLIAM B. KINTER; T. HASTINGS WILSON

1965-01-01

286

Comparative study on stress–strain hysteresis response of SAC solder joints under thermal cycles  

Microsoft Academic Search

The present study attempts to evaluate the stress-strain hysteresis responses of SAC solder joints in Resistor and FleXBGA144\\u000a packages subjected to thermal cyclic loading using several constitutive models. The total deformation of the solder material\\u000a consists of elastic, rate-independent plastic and rate-dependent creep components. The constitutive models discussed in this\\u000a study each weighted elastic, plastic and creep deformations differently. At

Alireza Shirazi; Ahmad Varvani-Farahani; Hua Lu

2008-01-01

287

Reduction of lead free solder aging effects using doped SAC alloys  

Microsoft Academic Search

The microstructure, mechanical response, and failure behavior of lead free solder joints in electronic assemblies are constantly evolving when exposed to isothermal aging and\\/or thermal cycling environments. In our prior work on aging effects, we have demonstrated that large degradations occur in the material properties (stiffness and strength) and creep behavior of Sn-Ag-Cu (SAC) lead free solders during aging. These

Zijie Cai; Yifei Zhang; Jeffrey C. Suhling; Pradeep Lall; R. Wayne Johnson; Michael J. Bozack

2010-01-01

288

Harmonic and Random Vibration Durability of SAC305 and Sn37Pb Solder Alloys  

Microsoft Academic Search

In this paper, durability tests were conducted on both SAC305 and Sn37Pb solder interconnects using both harmonic and random vibration. The test specimens consist of daisy-chained printed wiring boards (PWBs) with several different surface-mount component styles. Modal testing was first conducted on a test PWB to determine the natural frequencies and mode shapes. The PWB was then subjected to narrow-band

Y. Zhou; M. Al-Bassyiouni; A. Dasgupta

2010-01-01

289

KNApSAcK: A Comprehensive Species-Metabolite Relationship Database  

Microsoft Academic Search

We prepared a database, KNApSAcK for accumulation and search of metabolite-species relationships. The power-law distribution observed in the present study is likely to be associated with research activity for finding novel metabolites from nature. In addition, it seems to be derived from searching rare metabolites from the organisms originally exhibiting power-law in the degree distribution of their metabolic networks. This

Y. Shinbo; Y. Nakamura; M. Altaf-Ul-Amin; H. Asahi; K. Kurokawa; M. Arita; K. Saito; D. Ohta; D. Shibata; S. Kanaya

290

Effect of Hydrogen Sulfide on Northern Pike Eggs and Sac Fry  

Microsoft Academic Search

A series of bioassays were conducted to test the effect of H2S at two concentrations of oxygen on northern pike (Esox lucius L.) eggs and sac fry. At an oxygen concentration of approximately 2 ppm mean median tolerance limits (TLm) for eggs were 0.411, 0.076, 0.038, 0.034, and 0.030 ppm H2S for 24, 48, 72, 96 hours, and for the

Ira R. Adelman; Lloyd L. Smith Jr

1970-01-01

291

Effect of hydrogen sulfide on northern pike eggs and sac fry  

Microsoft Academic Search

A series of bioassays were conducted to test the effect of HâS at two concentrations of oxygen on northern pike (Esox lucius L.) eggs and sac fry. At an oxygen concentration of approximately 2 ppm mean median tolerance limits (TL\\/sub m\\/) for eggs were 0.411, 0.076, 0.038, 0.034, and 0.030 ppm HâS for 24, 48, 72, 96 hours, and for

IRA R. ADELMAN; LLOYD L. SMITH

1970-01-01

292

Actin coronas in normal and indeterminate gametophyte1 embryo sacs of maize  

Microsoft Academic Search

The actin cytoskeletal organization and nuclear behavior of normal and indeterminate gametophyte1 (ig1) embryo sacs of maize were examined during fertilization. After pollination, during degeneration of one of the synergids\\u000a and before arrival of the pollen tube, the cytoskeletal elements undergo dramatic changes including formation of the actin\\u000a coronas at the chalazal end of the degenerating synergid and at the

Bing-Quan Huang; W. F. Sheridan

1998-01-01

293

Development of a microstructurally adaptive unified primary-cumsecondary creep model for SAC387 solder joints  

Microsoft Academic Search

Sn-Ag-Cu (SAC) solders are susceptible to appreciable microstructural coarsening due to the combined effect of thermal and mechanical stimuli during service and storage. This results in evolution of joint properties over time, and thereby influences the long-term reliability of microelectronic packages. Accurate prediction of this aging behavior is therefore critical for joint reliability predictions. Here, we study the coarsening behavior

Z. Huang; P. Kumar; I. Dutta; G. Subbarayan; V. Gupta; D. Chan; C. H. Wen

2010-01-01

294

The effects of SAC alloy composition on aging resistance and reliability  

Microsoft Academic Search

The microstructure, mechanical response, and failure behavior of lead free solder joints in electronic assemblies are constantly evolving when exposed to isothermal aging and\\/or thermal cycling environments. In our prior work on aging effects, we have demonstrated that the observed material behavior variations of Sn-Ag-Cu (SAC) lead free solders during room temperature aging (25degC) and elevated temperature aging (125degC) were

Yifei Zhang; Zijie Cai; Jeffrey C. Suhling; Pradeep Lall; Michael J. Bozack

2009-01-01

295

Aplicación del método SAC a líneas de Fe II en atmósferas extendidas de estrellas Be  

NASA Astrophysics Data System (ADS)

En el presente trabajo hemos analizado las líneas de Fe II en emisión, para varios multipletes en el rango óptico, presentes en los espectros de un grupo de estrellas Be. Mediante la aplicación del método de curvas de autoabsorción (SAC), obtenemos una estimación del valor de los parámetros característicos de la región en la cual se forman dichas líneas, tales como temperatura de excitación, opacidad y dimensión.

Arias, M. L.; Zorec, J.; Cidale, L.; Morrell, N.; Friedjung, M.; Chauville, J.; Ballereau, D.

296

Asymmetric cell division of rice zygotes located in embryo sac and produced by in vitro fertilization  

Microsoft Academic Search

In angiosperms, a zygote generally divides into an asymmetric two-celled embryo consisting of an apical and a basal cell.\\u000a This unequal division of the zygote is a putative first step for formation of the apical–basal axis of plants and is a fundamental\\u000a feature of early embryogenesis and morphogenesis in angiosperms. Because fertilization and subsequent embryogenesis occur\\u000a in embryo sacs, which

Akiko Sato; Kiminori Toyooka; Takashi Okamoto

2010-01-01

297

The GaAs deployable solar array for SAC-B  

Microsoft Academic Search

SAC-B is an Argentinian scientific satellite, planned for launch in 1995 into a 550 km circular orbit by Pegasus vehicle for a 3 years mission. The solar array is made up of 4 deployable panels, embodying approximately 1000 LPE GaAs solar cells (30×41 mm2), capable of providing 215 W at 28 V at end of life. The mechanical structure of

A. Caon; L. Brambilla; R. Contini; G. D'Accolti; E. Rossi; G. Verzeni; C. Flores; F. Paletta; G. Pedrazzoli; M. Grattarola; F. Svelto; R. Ibba

1994-01-01

298

Performance enhancement of SAC-OCDMA system using modified-AND subtraction detection  

Microsoft Academic Search

Technology is already on the move towards exploiting the limits of the fiber's physical properties and more sophisticated techniques will be needed to increase the throughput and counteract the transmission impairments. In this paper, we present a new detection technique called the modified-AND subtraction detection for spectral-amplitude coding optical code-division multiple access (SAC-OCDMA) systems. This detection technique is based upon

Hamza M. R. Al-Khafaji; S. A. Aljunid; Hilal A. Fadhil

2011-01-01

299

Copper Sulfate Toxicity to Channel Catfish Fry: Yolk Sac versus Swim-Up Fry  

Microsoft Academic Search

Yolk sac and swim-up fry from five separate spawns of channel catfish Ictalurus punctatus were exposed to dissolved copper sulfate (CuSO4) in a series of static toxicity bioassays to observe age sensitivity at 24 and 48 h in waters with two different chemistries at a temperature of 23.1 ± 0.47°C (mean ± SD). The two waters were (1) well water

David L. Straus

2008-01-01

300

The internal vertebral venous plexus prevents compression of the dural sac during atlanto-axial rotation  

Microsoft Academic Search

Deformation of the extradural space and the possibility of impression upon the dural sac during atlanto-axial rotation are\\u000a investigated. Atlanto-axial rotation leads to a reduction in the cross-sectional area of the bony spinal canal of approximately\\u000a 40 %. Atlanto-axial rotation was recorded by endocanalar views from a video camera fixed inside the skull of six unembalmed\\u000a cadavers. Axial thin-section T1-weighted

E. M. Reesink; J. T. Wilmink; H. Kingma; L. M. A. Lataster; H. van Mameren

2001-01-01

301

Volatile constituents of dog ( Canis familiaris ) and coyote ( Canis latrans ) anal sacs  

Microsoft Academic Search

The volatile organic compounds from the anal sac secretions of male and female dogs and coyotes were examined using gas chromatography and gas chromatography-mass spectrometry. Short chain (C2–C6) acids and trimethylamine were major constituents. Changes in the type and abundance of the volatiles were examined across state of estrus, species, and gender. No consistent difference in the pattern of volatiles

George Preti; Earl L. Muetterties; Joseph M. Furman; James J. Kennelly; Bradford E. Johns

1976-01-01

302

Measurement of hydroxyproline and nitric oxide, and comparison of sac fluid acidity in different inguinal pathologies.  

PubMed

PURPOSE: To compare hydroxyproline and nitric oxide levels, and fluid acidity between sac tissues from inguinal hernia, hydrocele and undescended testis patients. MATERIAL AND METHOD: Thirty patients were in the inguinal hernia group, 11 patients in the hydrocele group and 5 patients in the undescended testis with inguinal hernia group. Intrasaccular fluid acidity, and nitric oxide and hydroxyproline levels in sac tissues were measured and analyzed statistically between groups. RESULTS: Intrasaccular fluid could be obtained from 24 inguinal hernia and 6 hydrocele patients. Acidity level (pH) was 7.5 ± 0.74 in the hernia group and 7.86 ± 0.63 in the hydrocele group (p < 0.05). All patients in the three groups were evaluated for nitric oxide and hydroxyproline. Results for hydroxyproline (mg/g dry tissue)/nitric oxide (nmol/g wet tissue) were 3.53 ± 0.54/2.02 ± 0.39 for inguinal hernia, 2.89 ± 0.9/1.92 ± 1.05 for hydrocele and 3.02 ± 1.23/2.86 ± 1.09 for undescended testis group (p > 0.05). CONCLUSION: Hydroxyproline and nitric oxide pathways do not seem to be responsible for the different characteristics of inguinal diseases. However, differences in the acidity of sac fluid may be evidence of the different mechanisms of hernia and hydrocele formation. PMID:23706381

Senayl?, Atilla; Ekici, Fatih; Y?lmaz, Resul; Erdo?an, Hasan

2013-05-22

303

Management of non-Hodgkin lymphomas arising at extranodal sites.  

PubMed

Primary extranodal lymphomas are relatively rare non-Hodgkin lymphoma presentations with either no or only "minor" nodal involvement along with a clinically "dominant" extranodal component, to which primary treatment must often be directed. Clinical presentations depend largely on the localization and are similar to those of other malignancies affecting that specific organ. In addition to the histological subtype, the primary organ of origin represents the most significant prognostic factor due to differences in natural history and, mainly, in management strategies related to organ-specific problems. In principle, as for primary nodal disease, treatment strategies depends on the patient's clinical conditions, the extent and/or location of the disease, and the histological type. In general, for stage I and II disease with low tumor burden, local therapy is a relevant option both for cure and local control. In advanced stage disease, systemic chemoimmunotherapy is usually required. Localizations with particularly poor survival are the enteropathy-type T-cell lymphoma, the primary testicular diffuse large B-cell lymphoma, and the primary CNS Lymphoma. However, recent studies have shown that site-tailored treatment strategies in testis and brain lymphoma may result in a significant outcome improvement. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is the most common indolent subtype. This lymphoma usually arises in mucosal sites where lymphocytes are not normally present and where a lymphoid infiltration is acquired in response to either chronic infectious conditions or autoimmune processes: Helicobacter pylori gastritis, Hashimoto's thyroiditis, Sjögren syndrome. Indeed, a pathogenetic link between gastric MALT lymphoma and H. pylori is strongly suggested by the regression of gastric MALT lymphoma (in approx. 75% of cases) after antibiotic eradication of the microorganism. PMID:20886458

Zucca, Emanuele; Gregorini, Anna; Cavalli, Franco

2010-10-01

304

Separation of Viable 'Rickettsia typhi' from Yolk Sac and L Cell Host Components by Renografin Density Gradient Centrifugation.  

National Technical Information Service (NTIS)

Rickettsia typhi cultivated in the yolk sac of chicken embryos or in L cells irradiated 7 days previously was separated from host cell components by two cycles of Renografin density gradient centrifugation. Preliminary steps involved differential centrifu...

E. Weiss J. C. Coolbaugh J. C. Williams

1975-01-01

305

Beneficial effect of S-allylcysteine (SAC) on blood glucose and pancreatic antioxidant system in streptozotocin diabetic rats.  

PubMed

The aim of the present study was to evaluate the possible protective effects of S-allyl cysteine (SAC) on the antioxidant defense system of pancreas in streptozotocin(STZ) induced diabetes in rats. The levels of blood glucose and TBARS in plasma and pancreas were estimated in control and experimental groups of rats. To assess the changes in the cellular antioxidant defense system, the level of reduced glutathione in plasma and pancreas and activities of superoxide dismutase and catalase were assayed in pancreatic tissue homogenate. The levels of glucose, TBARS and enzymatic antioxidants were altered in diabetic rats. These alterations were reverted back to near control levels after the treatment of SAC. The antidiabetic and antioxidant effect of SAC was compared with glyclazide, a well-known hypoglycemic drug. These findings suggest that SAC treatment exerts a therapeutic protective nature in diabetes by decreasing oxidative stress. PMID:20839055

Saravanan, Ganapathy; Ponmurugan, Ponnusamy

2010-12-01

306

Late recurrence of a cardiac glomus tumor.  

PubMed

Glomus tumors, also known as paragangliomas or chemodectomas, arise from well-differentiated mesenchymal cells that are known to be benign. These tumors account for 2% of all soft tissue tumors. The first case of a cardiac glomus tumor was reported in 1924 by Masson.1 Glomus tumors located within the pericardial tissue are extremely rare. We present the case of a recurrent cardiac glomus tumor. The preoperative investigation, diagnostic problems and surgical treatment of this case will be highlighted. Moreover we wish to emphasize the importance of such an entity and to remind readers that it must be included in the differential diagnosis of a pericardial tumor. PMID:21452115

Elkrinawi, R; Usta, E; Baumbach, H; Franke, U F W

2011-03-30

307

Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors  

ClinicalTrials.gov

Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Childhood Choroid Plexus Tumor; Childhood Craniopharyngioma; Childhood Ependymoblastoma; Childhood Grade I Meningioma; Childhood Grade II Meningioma; Childhood Grade III Meningioma; Childhood High-grade Cerebellar Astrocytoma; Childhood High-grade Cerebral Astrocytoma; Childhood Infratentorial Ependymoma; Childhood Low-grade Cerebellar Astrocytoma; Childhood Low-grade Cerebral Astrocytoma; Childhood Medulloepithelioma; Childhood Mixed Glioma; Childhood Oligodendroglioma; Childhood Supratentorial Ependymoma; Extra-adrenal Paraganglioma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Spinal Cord Neoplasm; Recurrent Childhood Subependymal Giant Cell Astrocytoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Childhood Visual Pathway and Hypothalamic Glioma

2013-05-01

308

Collision tumor of the colon – colonic adenocarcinoma and ovarian granulosa cell tumor  

Microsoft Academic Search

BACKGROUND: Collision tumors of the colon are rare. We report the first case, to our knowledge in the English literature, of a collision tumor composed of a colonic adenocarcinoma arising in a sigmoid diverticulum coexisting with a recurrent ovarian granulosa cell tumor. CASE PRESENTATION: A 64-year old woman presented with small bowel obstruction and a large, heterogenous, solid\\/cystic serosal based

Mayur Brahmania; Chandra S Kanthan; Rani Kanthan

2007-01-01

309

Clear cell carcinoid tumor of the distal common bile duct  

Microsoft Academic Search

BACKGROUND: Carcinoid tumors rarely arise in the extrahepatic bile duct and can be difficult to distinguish from carcinoma. There are no reports of clear cell carcinoid (CCC) tumors in the distal bile duct (DBD) to the best of our knowledge. Herein, we report a CCC tumor in the DBD and review the literature concerning extrahepatic bile duct carcinoid tumors. CASE

Takeshi Todoroki; Takaaki Sano; Shuji Yamada; Nobutsune Hirahara; Naotaka Toda; Katsuhiko Tsukada; Ryuji Motojima; Teiji Motojima

2007-01-01

310

A Solid Pseudopapillary Tumour Arising from Mesocolon without Ectopic Pancreas  

PubMed Central

A solid pseudopapillary tumour (SPT) is an uncommon pancreatic tumour. Very rarely it has also been described outside the pancreas, usually arising from heterotopic pancreatic tissue. In this paper, we described a case arising from the transverse mesocolon without heterotopic pancreatic tissue in an 18-year-old girl.

Tez, Mesut; Ozalp, Necdet; Zulfikaroglu, Bar?s; Koc, Mahmut

2010-01-01

311

?-Fetoprotein-Producing Non-Germ Cell Tumors of the Urological System  

PubMed Central

Elevated serum levels of ?-fetoprotein (AFP), a fetal serum protein, occur mainly in the development of hepatocellular carcinoma (HCC) or germ cell tumors, mainly yolk sac tumor. Rarely, other tumors of the urological system produce AFP. This article reviews the AFP-producing non-germ cell tumors of the urological tract reported to date. These include different types of tumors of the adrenal glands, kidney, ureter, urinary bladder, and testis. It is important for pathologists, urologists, and oncologists to be aware of such cases as the diagnosis affects the management plan for the patient.

El-Bahrawy, Mona

2011-01-01

312

Serous carcinoma arising in endometrial polyps: clinicopathologic study of 4 cases.  

PubMed

Uterine serous carcinoma (USC) is a rare variant of endometrial cancer that is not related to increased estrogen level; rather, it arises in a background of atrophic endometrium. Our aim was to describe clinicopathologic features of 4 cases of USC arising in endometrial polyps (EPs). The mean age of the patients at presentation was 53 years (range, 50-61 years). All patients presented with postmenopausal bleeding. In 3 patients, endometrial curretings were done before surgery, which was reported as EP with superficial foci of USC, EP with few clusters of atypical cells, and high-grade serous carcinoma, respectively. All patients underwent hysterectomy with bilateral salpingo-oophorectomy and omental sampling. The uterine cavity showed an EP in all cases ranging in size from 2 to 3.5 cm (mean, 3 cm). The hysterectomy specimens revealed USC in EP as well as the adjacent endometrium in 3 patients. The nonneoplastic endometrium was atrophic in all cases. Residual tumor was not found in the endometrium in 1 case. Omental metastatic deposits were found in all cases. Tumor deposits were also seen in the serosa of uterus, fallopian tubes, and parametrium in 1 case. Two patients died of disease 2 years after diagnosis. The remaining 2 patients are alive after a follow-up of 3 years, respectively. In conclusion, USC is a rare aggressive tumor, and to establish the diagnosis, it is important to look for the small foci of the tumor in the atrophic endometrium and on the surface of the polyps as these patients are likely to harbor additional disease in the uterus or extrauterine sites. The postmenopausal group is at high risk for developing these tumors; therefore, all the endometrial biopsies/curettings and the EPs in this age group should be thoroughly sampled. PMID:23276456

Idrees, Romana; Din, Nasir Ud; Fatima, Saira; Kayani, Naila

2012-12-29

313

Thymoma and thymic carcinoma arising in a thymolipoma: report of a unique case.  

PubMed

Thymic carcinoma arising within a thymolipoma has not been reported previously. The authors present a unique case of thymoma and undifferentiated thymic carcinoma arising within a thymolipoma in a 36-year-old woman. The bulk of the resected mass was composed of benign fatty tissue admixed with foci of unremarkable thymic tissue; however, it also harbored a central solid mass showing undifferentiated thymic carcinoma associated with a type B2 thymoma. The carcinoma cells were positive for cytokeratin AE1/AE3, cytokeratin 19, and cytokeratin 8/18. They were negative for vimentin, cytokeratin 7, cytokeratin 20, CD5, epithelial membrane antigen, CD30, placental alkaline phosphatase, carcinoembryonic antigen, CD99, leukocyte common antigen, Epstein-Barr virus, inhibin alpha, and protein gene product 9.5. Rare tumor cells showed positive staining for chromogranin and synaptophysin. PMID:18480395

Haddad, Hussam; Joudeh, Amani; El-Taani, Hani; Mansour, Asem; Morcos, Basem; Fayoumi, Said; Sughayer, Maher

2008-05-14

314

Role of Actin-Bundling Protein Sac6 in Growth of Cryptococcus neoformans at Low Oxygen Concentration  

PubMed Central

Cryptococcus neoformans, the etiologic agent of cryptococcosis, is an obligately aerobic yeast that inhabits an environmental niche exposed to ambient air. The cell doubling time was significantly prolonged under 1% O2 relative to that under normoxic conditions. No apparent cell cycle arrest occurred following a shift from ambient air to 1% O2. However, yeast cells became hypersensitive to the actin monomer-sequestering agent latrunculin A at 1% O2, indicating that proper actin function is critical for growth at low oxygen concentrations. We showed that Sac6, an actin-binding protein, played an important role in cell growth under low oxygen conditions. Sac6 colocalized with cortical actin patches and with the ring structures between mother cells and buds. Under low oxygen conditions, the sac6 deletion mutant grew poorly, and accumulation of the actin capping protein Cap1 was observed in the vacuole of the sac6? strain. Furthermore, endocytic processes were hampered in the sac6? mutant, but cell polarity and cytokinesis were not visibly disturbed. The deficiency of endocytosis in the sac6? strain could be rescued by 1 M sorbitol under 1% O2, but growth remained retarded. These results suggest an absence of a direct link in C. neoformans between endocytosis and coping with the stress of low oxygen conditions. This interpretation is further supported by the observation that deletion of three conserved genes, ABP1, CRN1, and SLA2, which play important roles in endocytosis, had no effect on growth under 1% O2. Interestingly, deletion of SAC6 in C. neoformans had no effect on virulence in mice.

Lamichhane, Ami Khanal; Kwon-Chung, Kyung J.

2012-01-01

315

Peripheral Nerve Tumors  

Microsoft Academic Search

\\u000a Peripheral nerve tumors (PNTs) are rare soft tissue lesions that can arise anywhere on the body and as a result have a wide\\u000a differential diagnosis, which is often confirmed to be a PNT only at surgery. PNTs occur both sporadically and within the\\u000a context of genetically predisposing syndromes; hence, a thorough history of the mass and associated symptoms, with a

Joseph Wiley; Asis Kumar Bhattacharyya; Gelareh Zadeh; Patrick Shannon; Abhijit Guha

316

The acid-induced folded state of Sac7d is the native state.  

PubMed Central

Sac7d unfolds at low pH in the absence of salt, with the greatest extent of unfolding obtained at pH 2. We have previously shown that the acid unfolded protein is induced to refold by decreasing the pH to 0 or by addition of salt (McCrary BS, Bedell J. Edmondson SP, Shriver JW, 1998, J Mol Biol 276:203-224). Both near-ultraviolet circular dichroism spectra and ANS fluorescence enhancements indicate that the acid- and salt-induced folded states have a native fold and are not molten globular. 1H,15N heteronuclear single quantum coherence NMR spectra confirm that the native, acid-, and salt-induced folded states are essentially identical. The most significant differences in amide 1H and 15N chemical shifts are attributed to hydrogen bonding to titrating carboxyl side chains and through-bond inductive effects. The 1H NMR chemical shifts of protons affected by ring currents in the hydrophobic core of the acid- and salt-induced folded states are identical to those observed in the native. The radius of gyration of the acid-induced folded state at pH 0 is shown to be identical to that of the native state at pH 7 by small angle X-ray scattering. We conclude that acid-induced collapse of Sac7d does not lead to a molten globule but proceeds directly to the native state. The folding of Sac7d as a function of pH and anion concentration is summarized with a phase diagram that is similar to those observed for other proteins that undergo acid-induced folding except that the A-state is encompassed by the native state. These results demonstrate that formation of a molten globule is not a general property of proteins that are refolded by acid.

Bedell, J. L.; McCrary, B. S.; Edmondson, S. P.; Shriver, J. W.

2000-01-01

317

Minilaparoscopic herniorrhaphy with hernia sac transection in children and young adults: a preliminary report  

Microsoft Academic Search

Background  We designed a technique of pure minilaparoscopic hernia sac transaction and ligation to repair primary inguinal hernias in\\u000a children and young adults.\\u000a \\u000a \\u000a \\u000a Methods  Between September 2003 and December 2004, 83 patients with primary inguinal hernia were treated surgically with minilaparoscopic\\u000a herniorrhaphy. The mean patient age was 6.8 years. Before the operation there were synchronous bilateral hernias in 2 (2.4%)\\u000a patients, left

Yao Chou Tsai; Chia Chang Wu; Stephen Shei Dei Yang

2007-01-01

318

Melanoma arising on a scar 10 years after a burn: management and review of the literature.  

PubMed

We report a case of a melanoma arising after about 10 years after a burn injury. This is an uncommon example of a carcinogenetic event that could be prevented or diagnosed early. Usually, the mutagenic event clinically appears many years after the burn especially if it was not treated correctly with a careful surgical approach. The average time of latency could be found in literature as 46.5 years from the burn, whereas our case was only 10. A frequent and very long follow-up of the burn scars could represent a valid prophylactic option to avoid neoplastic proliferation if the tumor appears. PMID:22627497

Ribero, Simone; Grassi, Marcella; Caliendo, Virginia; Lauro, Danilo; Macripò, Giuseppe

2012-07-01

319

Localized pigmented villonodular synovitis: arthroscopic treatment of a lesion arising from the quadriceps tendon sheath.  

PubMed

Pigmented villonodular synovitis (PVNS) is a rare benign proliferative growth of synovium of obscure etiology with a wide spectrum of clinical presentation. Localized PVNS, also known as giant cell tumor of the tendon sheath, is even more uncommon. Localized PVNS of the knee is a rare, idiopathic condition presenting with symptoms that can mimic other intra-articular pathologies. The condition is usually monoarticular, the knee being the most commonly affected joint. We report a rare case of PVNS arising from the quadriceps tendon sheath. It was successfully treated with arthroscopic intralesional excision. At 18 months' follow-up, there has been no recurrence. PMID:17418347

Kakarala, Gopikrishna; Peddu, Praveen; Lahoti, Om

2006-10-16

320

Pericytoma with t(7;12) and ACTB-GLI1 Fusion Arising in Bone  

PubMed Central

Cytogenetic analysis of a primary bone neoplasm with pericytic features in a 67 year-old-male revealed a t(7;12)(p22;q13) among other karyotypic abnormalities. Subsequent molecular studies confirmed the presence of an associated ACTB-GLI1 fusion transcript. An identical 7;12 translocation is known to characterize a discrete group of soft tissue tumors belonging to the myopericytic category termed “pericytoma with t(7;12).” To the best of our knowledge, this is the first case of pericytoma with t(7;12) arising in bone. Cytogenetic and molecular analyses were useful, if not essential, in classifying this rare diagnostic entity.

Bridge, Julia A.; Sanders, Kyle; Huang, Dali; Nelson, Marilu; Neff, James R.; Muirhead, David; Walker, Craig; Seemayer, Thomas A.; Sumegi, Janos

2012-01-01

321

Borderline mucinous ovarian tumor presenting as pseudo-Meigs' syndrome.  

PubMed

Borderline ovarian tumor with the initial presentation of pseudo-Meigs' syndrome is rare. A 52-year-old postmenopausal woman presented with a large ovarian tumor, ascites, and right hydrothorax. We found elevated serum carcinoembryonic antigens (44.4 ng/mL), carbohydrate antigen (CA)-125 (269.8 U/mL), and CA-199 (7942 U/mL). The frozen section pathology revealed a mucinous borderline ovarian tumor, and a staging operation was performed. Final pathologic examination confirmed the diagnosis of intestinal type ovarian mucinous borderline tumor with non-invasive cul-de-sac implants. Her pleural effusion and ascites resolved after surgery, and she remained tumor-free after 3 years' follow up. Physicians should be cautious for the rare possibility of pseudo-Meigs' syndrome in patients with pelvic tumors having the features of advanced ovarian cancer. PMID:22672527

Chen, Yueh-Yi; Hsiao, Sheng-Mou; Hsu, Yao-Peng; Lin, Ho-Hsiung; Wei, Ming-Chow

2012-06-04

322

[Anti-angiogenic activities of UFT and its metabolites, GHB and GBL, in the dorsal air sac (DAS) model in mice].  

PubMed

We investigated the effects of UFT and its metabolites, GHB and GBL, on angiogenesis induced by tumor cells in a dorsal air sac (DAS) assay in mice. Five tumor cell lines (murine renal carcinoma; RENCA, human gastric cancer; 4-1ST, human small-cell lung carcinoma; LX-1, and human colon carcinoma; DLD-1, KM-20C) were used in the DAS assay. In this model, UFT demonstrated a significant anti-angiogenic activity in a dose-dependent manner while 5-FU (19 mg/kg/day) and 5'-DFUR (200 mg/kg/day) were less effective. Moreover, tegafur (FT), a component of UFT, and gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL), in vivo metabolites of UFT, inhibited angiogenesis induced by RENCA cells. The inhibitory effects of 5-FU, GHB, and GBL on angiogenesis were increased with administration by continuous infusion, providing a suitable pharmacokinetic profile. These results suggest that GHB and GBL are involved in the expression of anti-angiogenic activity of UFT. PMID:10660738

Basaki, Y; Yonekura, K; Chikahisa, L; Okabe, S; Hashimoto, A; Miyadera, K; Aoyagi, K; Yamada, Y

2000-01-01

323

Allergens in hymenoptera venoms. X. Vespid venoms versus venom sac extracts: comparison by two-dimensional polyacrylamide gel electrophoresis.  

PubMed

Vespid venoms were compared to venom sac extracts by two-dimensional polyacrylamide gel electrophoresis using non-equilibrium pH gradient electrophoresis in the first dimension and sodium dodecyl sulfate electrophoresis in the second. The gels were stained with silver. Fresh venoms from four species, Vespula maculifrons, Polistes fuscatus fuscatus, P. metricus and P. exclamans, were compared with commercially available venom sac extracts from the same species. In each case the venom sac extract contained all of the proteins detected in the fresh venom plus numerous additional proteins which are probably sac components. Yellow jacket and bee (Apis mellifera) proteins were extracted from the gels and tested for IgE binding activity using pooled sera from RAST-positive individuals. Significant IgE binding activity was found for the five known bee allergens and for the major yellow jacket venom proteins. Fresh pure vespid venoms contain a relatively small number of major protein subunits. Venom sac extracts contain the same components plus many other proteins not found in the pure venoms. PMID:6625227

Wood, C L; Timmons, B E; Hoffman, D R

1983-10-01

324

Gastrointestinal Stromal Tumor: A Rare Abdominal Tumor  

PubMed Central

Gastrointestinal stromal tumors (GISTs) are rare abdominal tumors which arise from the interstitial cells of Cajal in the gastrointestinal tract. Gastric GISTs are the most commonly seen GIST tumors and may grow to a very large size. They are often associated with abdominal pain, anorexia and weight loss. Most of them can be detected by CT. These tumors have been found to harbor mutations in CD117 which causes constitutional activation of the tyrosine kinase signaling pathway and is considered to be pathognomic. Tyrosine kinase inhibitors such as imatinib have revolutionized the treatment of these tumors, which are otherwise resistant to conventional chemotherapy and radiotherapy. Although surgical resection is the mainstay of treatment, tyrosine kinase inhibitors have been useful in prolonging the recurrence-free survival of these patients. Resistance to imatinib has been reported in GISTs with specific mutations. We present a case of gastric GIST which grew to a very large size and was associated with abdominal pain and weight loss. It was successfully resected and the patient was commenced on imatinib therapy.

Shaheen, Shagufta; Guddati, Achuta K.

2013-01-01

325

Benign sacrococcygeal neoplasm arising at birth from a giant congenital melanocytic nevus.  

PubMed

Giant congenital melanocytic nevi (CMN) are considered to be premalignant with the highest risk for conversion to melanoma. Solid tumors within giant CMN presenting at birth are relatively unusual, and a variety of malignancies have been reported within these masses. However, the frequency of malignancy in these tumors is unknown. We report the unusual case of a female neonate who was born with 2 large, perianal masses within a giant CMN over her trunk. We resected the larger of the 2 masses because of discomfort and bleeding. The mass consisted of an outgrowth of melanocytes with benign characteristics. The smaller of the 2 masses was managed expectantly and has subsequently decreased in size. We propose that pathologically benign masses within giant CMNs may not require immediate resection. We will discuss the management and pathologic findings of this case and review the literature regarding management of CMN-associated neoplasms arising at birth. PMID:22325403

Snyder, Jason A; Khozeimeh, Nini; Reyes, Christine; Qureshi, Faisal G

2012-02-01

326

Cloning structural gene sacB, which codes for exoenzyme levansucrase of Bacillus subtilis: expression of the gene in Escherichia coli.  

PubMed Central

A clone bearing the structural gene sacB, coding for the exoenzyme levansucrase, was isolated from a library of Bacillus subtilis DNA that was cloned in phage lambda charon 4A on the basis of the transforming activity of the chimeric DNA. This lambda clone also was found to contain the sacR and smo loci. Subcloning the sacB-sacR region in plasmid pBR325 resulted in a clone which directed levansucrase synthesis in Escherichia coli. The nucleotide sequence coding for the secreted protein was localized on the physical map of the cloned DNA. Images

Gay, P; Le Coq, D; Steinmetz, M; Ferrari, E; Hoch, J A

1983-01-01

327

Papillary adenocarcinoma with oncocytic features arising from the ethmoid sinus  

Microsoft Academic Search

Objectives: We report a case of low-grade papillary adenocarcinoma with unique oncocytic features arising in the ethmoid sinus of a 72-year-old female.Methods: A review of the case history, pathological findings, and medical literature is performed.Results: A 72-year-old female presented with a 2-month history of progressive right-sided nasal obstruction. Preoperative nasal endoscopy showed a glistening, pink-red, soft mass arising from the

Brennan Thomas Dodson; Bruce W. Jafek; Sherif Said

2004-01-01

328

Comparative Analysis and Functional Mapping of SACS Mutations Reveal Novel Insights into Sacsin Repeated Architecture  

PubMed Central

Autosomal recessive spastic ataxia of Charlevoix–Saguenay (ARSACS) is a neurological disease with mutations in SACS, encoding sacsin, a multidomain protein of 4,579 amino acids. The large size of SACS and its translated protein has hindered biochemical analysis of ARSACS, and how mutant sacsins lead to disease remains largely unknown. Three repeated sequences, called sacsin repeating region (SRR) supradomains, have been recognized, which contribute to sacsin chaperone-like activity. We found that the three SRRs are much larger (?1,100 residues) than previously described, and organized in discrete subrepeats. We named the large repeated regions Sacsin Internal RePeaTs (SIRPT1, SIRPT2, and SIRPT3) and the subrepeats sr1, sr2, sr3, and srX. Comparative analysis of vertebrate sacsins in combination with fine positional mapping of a set of human mutations revealed that sr1, sr2, sr3, and srX are functional. Notably, the position of the pathogenic mutations in sr1, sr2, sr3, and srX appeared to be related to the severity of the clinical phenotype, as assessed by defining a severity scoring system. Our results suggest that the relative position of mutations in subrepeats will variably influence sacsin dysfunction. The characterization of the specific role of each repeated region will help in developing a comprehensive and integrated pathophysiological model of function for sacsin.

Romano, Alessandro; Tessa, Alessandra; Barca, Amilcare; Fattori, Fabiana; Fulvia de Leva, Maria; Terracciano, Alessandra; Storelli, Carlo; Santorelli, Filippo Maria; Verri, Tiziano

2013-01-01

329

The importance of gestational sac size of ectopic pregnancy in response to single-dose methotrexate.  

PubMed

This retrospective cohort study was designed in a selective group of 185 patients diagnosed with and treated for ectopic pregnancy. Intramuscular administration of a single dose of methotrexate (50?mg/m(2)) was performed to measure predictors of failure or resistance to treatment necessitating surgical intervention. During the time of treatment with a single dose of MTX, 20 patients (10.8%) failed to response, in which 6 of 20 (30%) indicated side effects to MTX and rupture of the ectopic pregnancy. Remaining cases (n = 14) showed resistance to the drug; the level of ? -hCG did not fall at least 15% during 7 days after treatment and necessitated laparotomy. In backward-step analysis by multiple logistic regressions of various types of predictor factors, size of gestational sac (coefficient = 1.91, OR = 6.78, 95% confidence interval = 3.18-8.22) and baseline level ? -hCG (coefficient = 1.60, OR = 5.0, 95% confidence interval = 4.26-6.72) had significant correlation with leading EP patients failing to response to MTX. This study suggests that further investigation for finding relative contraindications of MTX treatment in EP women should be considered on the gestational sac size because other variables are in the causal pathway of this variable. PMID:23762575

Kimiaei, Parichehr; Khani, Zahra; Marefian, Azadeh; Gholampour Ghavamabadi, Maryam; Salimnejad, Maryam

2013-05-14

330

The Role of Elastic and Plastic Anisotropy of Sn in Recrystallization and Damage Evolution During Thermal Cycling in SAC305 Solder Joints  

NASA Astrophysics Data System (ADS)

Because failures in lead-free solder joints occur at locations other than the most highly shear-strained regions, reliability prediction is challenging. To gain physical understanding of this phenomenon, physically based understanding of how elastic and plastic deformation anisotropy affect microstructural evolution during thermomechanical cycling is necessary. Upon solidification, SAC305 (Sn-3.0Ag-0.5Cu) solder joints are usually single or tricrystals. The evolution of microstructures and properties is characterized statistically using optical and orientation imaging microscopy. In situ synchrotron x-ray measurements during thermal cycling are used to examine how crystal orientation and thermal cycling history change strain history. Extensive characterization of a low-stress plastic ball grid array (PBGA) package design at different stages of cycling history is compared with preliminary experiments using higher-stress package designs. With time and thermal history, microstructural evolution occurs mostly from continuous recrystallization and particle coarsening that is unique to each joint, because of the specific interaction between local thermal and displacement boundary conditions and the strong anisotropic elastic, plastic, expansion, and diffusional properties of Sn crystals. The rate of development of recrystallized microstructures is a strong function of strain and aging. Cracks form at recrystallized (random) boundaries, and then percolate through recrystallized regions. Complications arising from electromigration and corrosion are also considered.

Bieler, Thomas R.; Zhou, Bite; Blair, Lauren; Zamiri, Amir; Darbandi, Payam; Pourboghrat, Farhang; Lee, Tae-Kyu; Liu, Kuo-Chuan

2012-02-01

331

Chemically intuitive indices for charge-transfer excitation based on SAC-CI and TD-DFT calculations.  

PubMed

A recently proposed charge-transfer (CT) index and some related quantities aimed to the description of CT excitations in push-pull donor-acceptor model systems were computed in vacuum and in ethanol by the direct symmetry-adapted cluster-configuration interaction (SAC-CI) method including solvent effects by means of the nonequilibrium state-specific approach. The effects of both solvation and electron correlations on these quantities were found to be significant. The present results are also in line with previous time-dependent (TD) density functional theory calculations and they demonstrate that SAC-CI provides a description of the excitation character close to that of TD-PBE0. Indeed, CT indices evaluated by the SAC-CI and TD-PBE0 would be useful in the field of materials chemistry, for the design and development of novel molecular materials. © 2013 Wiley Periodicals, Inc. PMID:24037799

Ehara, Masahiro; Fukuda, Ryoichi; Adamo, Carlo; Ciofini, Ilaria

2013-08-26

332

Symptomatic Hibernoma: A Rare Soft Tissue Tumor  

PubMed Central

Hibernomas are benign soft tissue tumors containing prominent brown adipocytes that resemble normal brown fat. Hibernomas have not been associated with malignant potential; however, they are similar in clinical presentation to malignant tumors like liposarcomas. This article describes the clinical, radiographic, and histologic features of a patient with a hibernoma arising from the left superior flank.

Lim, Robert B; Lin-Hurtubise, Kevin; Johnson, Eric A

2012-01-01

333

Large Intrathoracic Tumors in Children: Imaging Findings  

Microsoft Academic Search

Massive benign or malignant thoracic tumors in children may arise from the chest wall, pleura, lung parenchyma, or mediastinum and may be primary or secondary. On initial chest radiographs, these masses usually appear as an opaque hemithorax or an obvious large opaque mass. If the site of on- gin of the intrathoracic tumor can be determined, the differen- tial diagnosis

Deborah S. Ablin; E. Michel Azouz; Kiran A. Jam

334

Updates on abdominal desmoid tumors  

Microsoft Academic Search

Desmoid tumor is a monoclonal, fi broblastic proliferation arising in musculoaponeurotic structures. This connective tissue hyperplasia infi ltrates locally, recurs frequently after resection but does not metastasize. Abdominal desmoid occurs sporadically, in association with some familial syndromes and often represents a clinical dilemma for surgeons. The enigmatic biology and anatomical location of abdominal desmoids make treatment recommendations diffi cult. This

Bernardino Rampone; Corrado Pedrazzani; Daniele Marrelli; Enrico Pinto; Franco Roviello

2007-01-01

335

A case of squamous cell carcinoma arising from a suprapubic cystostomy tract  

PubMed Central

Background Patients with spinal cord injury and a chronic indwelling urinary catheter are known to have an increased risk of bladder malignancy. However, squamous cell carcinoma (SCC) of the epidermis around a suprapubic cystostomy is relatively rare. Here, we report a case of lower abdominal SCC arising from the suprapubic cystostomy tract. Case presentation A 58-year-old man with a complete spinal cord injury was referred to our hospital with a chief complaint of an abdominal mass. Abdominal enhanced computed tomography (CT) showed a 7-cm mass surrounding the suprapubic cystostomy and bilateral inguinal and para-aortic lymph nodes metastasis. Histopathological examination of percutaneous biopsy specimens was performed. The diagnosis was stage IV (cT4N1M1) epidermal SCC, which was treated with palliative external radiation therapy. Conclusion The SCC in this case was thought to arise from mechanical stimulus of the suprapubic cystostomy. Physicians and patients should pay careful attention to any signs of neoplasms with long-term indwelling catheters, such as skin changes around the suprapubic cystostomy site. This case presentation is only the fourth report of SCC arising from the suprapubic cystostomy tract in the literature. In cases of unresectable tumors and contraindications to chemotherapy, palliative radiotherapy may lead to disease remission and symptom relief.

2011-01-01

336

The stress-strain relationship of Sn63Pb37 and SAC305 solder materials at elevated temperature condition  

Microsoft Academic Search

This paper is emphasized on the compression behavior of Sn-3Ag-0.5Cu (SAC305) and Sn-37Pb at elevated temperatures. The effect of temperature for Sn-3Ag-0.5Cu (SAC305) and Sn-37Pb alloys was also discussed. The Quasi-static compression test was also conducted by using the SHIMAZDU AG-X material testing machine and the loading rare was chosen to be 1.67×10-3 s-1 and 1.67×10-4 s-1. Moreover, heating oven

Syh-Tsang Jenq; Yuen-Sheng Chiu; Ren-Jey Lin; Yi-Shao Lai

2010-01-01

337

Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation.  

PubMed

Megalin and cubilin are multifunctional endocytic receptors associated with many transporting epithelia. They play an essential role in transport of nutrients through the visceral yolk sac of rodents during embryogenesis. Here, we immunolocalise them to the endodermal layer of the human yolk sac, and to the syncytiotrophoblast and cytotrophoblast cells of placental villi. In villi, the protein level of both receptors increased with gestation. The mRNA for megalin remained constant, while that encoding cubilin increased with gestation. These results suggest megalin and cubilin may be important in human maternal-fetal transfer, and that they increase across gestation to facilitate this function. PMID:23978537

Burke, K A; Jauniaux, E; Burton, G J; Cindrova-Davies, T

2013-08-23

338

Inheritance and mapping of embryo sac abortion in hybrid between Indica and Japonica rice (Oryza sativa L.).  

PubMed

A doubled haploid (DH) population derived from anther culture of F(1)'s between an Indica var. Zhai-Ye-Qing 8 and a Japonica var. Jing-Xi17 as well as two backcross populations derived from this DH population were used to investigate inheritance of the embryo sac abortion at early megagametogenesis occurring in Indica/Japonica rice crosses. Two major loci, dominant and complementaryesa-1 andesa-2, located on chromosomes 6 and 12 respectively, were detected. Genetic analysis indicated that embryo sac fertility is mainly regulated by the gametophytic genotype at these two loci. PMID:18425633

Yongsheng, L; Lihuang, Z; Jingsan, S; Lishuang, S; Yuzhong, W; Ping, H; Chaofu, L; Ying, C

1998-06-01

339

Study on membrane recycling in the rat visceral yolk-sac endoderm using concanavalin-A conjugates  

Microsoft Academic Search

Summary  The internalization and intracellular movements of apical-cell-membrane material were investigated in the endodermal cells\\u000a of cultured visceral yolk-sacs of rats (whole-embryo culture; explanted at 10.5 days of gestation and cultured for 24h) using\\u000a horseradish peroxidase- and ferritin-labelled concanavalin A (Con-A HRP, Con-A Fer). When visceral yolk-sac endoderm was exposed\\u000a to Con-A HRP or Con-A Fer for 5 min at 4°C,

P. Kugler; A. Miki

1985-01-01

340

Spinal Tumor  

MedlinePLUS

... the diagnosis and pinpoint the tumor's location: Spinal magnetic resonance imaging (MRI). MRI uses a powerful magnet ... and staging of spine tumors. Orthopedic Clinics of North America. 2009;40:1. Brain and spinal tumors: ...

341

Spinal tumor  

MedlinePLUS

Tumor - spinal cord ... spinal tumors occur in the nerves of the spinal cord itself. Most often these are ependymomas and other ... genetic defects. Spinal tumors can occur: Inside the spinal cord (intramedullary) In the membranes (meninges) covering the spinal ...

342

Bone Tumor  

MedlinePLUS

... include: Non-ossifying fibromaunicameral (simple) bone cyst Osteochondroma Giant cell tumor Enchondroma Fibrous dysplasia Top of page ... http://orthoinfo.aaos.org/topic.cfm?topic=A00083) Giant Cell Tumor of Bone Giant Cell Tumor of ...

343

Cellular immunity and immunotherapy of brain tumors.  

PubMed

Factors influencing the host immune response to central nervous system (CNS) tumors are not yet well understood. This review will outline what is known about anti-tumor immune responses against CNS tumors and describe how advances in our knowledge of basic immunology may be applied to brain tumor immunotherapy. We will first focus on cellular immune system interactions involved in peripheral anti-tumor immune responses. Then, we will discuss characteristics of tumors arising within the confines of the CNS that distinguish them from peripheral neoplasms, emphasizing immune defects that seem to limit or curtail specific anti-tumor immunity against brain tumors. Finally, the current state of immune-based treatment paradigms and future directions will be discussed, paying particular attention to adoptive cellular immunotherapy and tumor vaccine approaches for the treatment of malignant gliomas. PMID:15353342

Prins, Robert M; Liau, Linda M

2004-09-01

344

[Impressions about responses arising from a sense of unwanted transparency].  

PubMed

The sense of unwanted transparency is the feeling that another person seemingly notices something about us that we would rather conceal. Two experiments were conducted to investigate impressions about responses arising from the sense of unwanted transparency. In Study 1, observers were asked to watch the videotape recorded in Tabata (2009) and judge the participants' responses arising from the sense of unwanted transparency. In Study 2, based on Tabata (2009), both verbal responses and nonverbal responses that were characteristic in arousing the sense of unwanted transparency were manipulated in the videotaped conversation. Participants were asked to watch the videotape and judge the confederate's impressions. The results indicated that unnatural impressions were heightened by nonverbal responses such as longer silences, averting the gaze, and increased self-touching. This suggests that these responses arising from the sense of unwanted transparency may produce a self-fulfilling prophecy. However, seemingly deceptive verbal responses were only related to the dubious impressions of the statements. PMID:21400867

Tabata, Naoya

2011-02-01

345

Videolaparoscopy of the contralateral internal inguinal ring via the hernia sac in children with unilateral inguinal hernia-initial experience in Brazil, with a meta-analysis  

Microsoft Academic Search

Videolaparoscopy of the contralateral internal inguinal ring (CIIR) via the hernia sac was performed in 100 children with a unilateral inguinal hernia (UIH) between August 1996 and May 1999. During general anesthesia, after dissection and opening of the hernia sac with the patient in the Trendelenburg position, the external cannula of a 10-mm trocar was introduced into the peritoneal cavity

Marcelo Eller Miranda; José Duarte Lanna

2002-01-01

346

Acinar cell carcinoma arising from an ectopic pancreas.  

PubMed

We herein report a rare case of ectopic pancreatic acinar cell carcinoma (ACC) which presented as a submucosal tumor of the pylorus. A 73-year-old man came to our hospital presenting with epigastralgia. Esophago-gastroduodenal endoscopy showed no mucosal lesions, but a submucosal tumor was observed around the pylorus. Abdominal computed tomography revealed two round masses. One was located in the pylorus, while the other was found between the portal vein and the inferior vena cava. An examination of a biopsy specimen was inconclusive. We diagnosed a gastrointestinal stromal tumor or malignant lymphoma preoperatively, and decided to perform an operation in order to confirm the diagnosis and select the optimal treatment. Intraoperatively, the mass in the pylorus invaded the pancreatic head, and the lymph node in the hepatoduodenal ligament was swollen. We performed a pancreaticoduodenectomy as a radical excision. The resected specimen showed the 7.6 x 4.9-cm size tumor to mainly originate from the pylorus. Histopathologically, the tumor was identified as pancreatic ACC with lymph node metastasis. The tumor cells were labeled by immunohistochemical staining for alpha1-antitrypsin. Because of the tumor location, we considered the tumor to have originated from the ectopic pancreatic tissue in the stomach. This is only the second case of ACC originating from an ectopic pancreas reported in the literature. PMID:17643220

Mizuno, Yoshimasa; Sumi, Yasuhiro; Nachi, Sho; Ito, Yoshihiro; Marui, Tsutomu; Saji, Shigetoyo; Matsutomo, Hirokazu

2007-07-26

347

Zebrafish models of germ cell tumor.  

PubMed

Germ cell tumors are neoplasms arising from pluripotent germ cells. In humans, these tumors occur in infants, children and young adults. The tumors display a wide range of histologic differentiation states which exhibit different clinical behaviors. Information about the molecular basis of germ cell tumors, and representative animal models of these neoplasms, are lacking. Germline development in zebrafish and humans is broadly conserved, making the fish a useful model to probe the connections between germ cell development and tumorigenesis. Here, we provide an overview of germline development and a brief review of germ cell tumor biology in humans and zebrafish. We also outline some methods for studying the zebrafish germline. PMID:21951524

Neumann, Joanie C; Lillard, Kate; Damoulis, Vanessa; Amatruda, James F

2011-01-01

348

Effects of serum concentration on some growth characteristics of cultured murine parietal yolk sac carcinoma cells.  

PubMed

Murine parietal yolk sac carcinoma cells were examined by scanning and transmission electron microscopy to determine the ultrastructural changes resulting from growth, in vitro, in media containing different serum concentrations. Cells grown in medium supplemented with 10% fetal bovine serum (FBS) formed spherical bodies, were gradually oval with numerous surface microvilli, well-organized microtubules, abundant free polysomes and a well-developed Golgi apparatus. By contrast, cells grown in 1% FBS failed to form multicellular spheres, were generally flattened over the growth surface and lacked the surface and intracellular features demonstrated when cells were grown in 10% serum. These differences could explain the alterations in the glycosylation of secreted glycoprotein associated with culture in the presence of low serum. PMID:7147224

Johnson, L D; Bergin, M E; Borg, T K

1982-01-01

349

[The case of the nematode Setaria equina found in the vaginal sac of the stallion's scrotum].  

PubMed

The nematode Setaria equina usually reside in body cavities and do not cause clinical symptoms. From time to time, however, these parasites can be located in the scrotum and spermatic cord inflicting pain and edema in these body parts. The aim of the study was to describe the case of the nematode Setaria equina found in the vaginal sac of the stallion's scrotum. During the study, thorough examination of 50 isolated testicles of 25 stallions was conducted. The horses were obtained post-slaughter from the local slaughterhouse near Krakow. In one of examined stallions, two females of Setaria equina of 80 and 110 mm in length were found attached to the surface of the testicle. A part of one of the nematode was found in the space between the surface of the testicle and the epididymis. During the examination of the testicle sections, chronic inflammation (orchitis chronica) and focal necrosis perivascularis were found. PMID:21452525

Korna?, S?awomir; Pozor, Ma?gorzata; Okólski, Adam; Nowosad, Bogus?aw

2010-01-01

350

Response of the pigeon crop sac to mammotrophic hormones: Comparison between relaxin and prolactin  

SciTech Connect

The effects of relaxin (RLX), a hormone that has previously been demonstrated to have mammotrophic properties, were studied in the pigeon crop sac, a well-known target organ for mammotrophic and lactogenic hormones, and compared with the effects produced by prolactin (PRL). The two hormones were injected directly over the crop at different doses and the response was evaluated after differing times of exposure. RLX causes a dose-related increase in wet and dry weights and ({sup 3}H)thymidine and ({sup 3}H)uridine uptake by the crop mucosa, as well as morphological changes indicating growth and differentiation of the epithelial cells similar to those occurring during physiological activation in incubation and hatching. At the doses assayed, the effects of RLX were nearly identical to those obtained following PRL in the short-term experiments, but differences in functional responses were found in the long-term experiment.

Bani, G.; Sacchi, T.B.; Bigazzi, M. (Univ. of Florence (Italy))

1990-10-01

351

A climatology of multiple tropopauses derived from GPS radio occultations with CHAMP and SAC-C  

NASA Astrophysics Data System (ADS)

A global climatology of multiple tropopauses (MT) is discussed based on Global Positioning System (GPS) radio occultation (RO) data from the German CHAMP (CHAllenging Minisatellite Payload) and the US-Argentinian SAC-C (Satelite de Aplicaciones Cientificas-C) satellite mission for the period May 2001-April 2005. In this study we present first detailed investigations about the geographical and temporal distribution of MT during different seasons. The thickness of the layer between the lowest (first) and highest (last) tropopause has a strong annual cycle. In the vicinity of the subtropical jet (STJ) stream region values vary between 4-5 km during winter and 2-3 km during summer, respectively, whereas higher differences were found on the northern hemisphere. It is shown that the occurrence distribution of MT is in good agreement with the mean climatological location of the STJ (30°-40°) on both hemispheres, in particular during winter time.

Schmidt, T.; Beyerle, G.; Heise, S.; Wickert, J.; Rothacher, M.

2006-02-01

352

Kr?ppel-like Factor 2 Regulated Gene Expression in Mouse Embryonic Yolk Sac Erythroid Cells  

PubMed Central

KLF2 is a Krüppel-like zinc-finger transcription factor required for blood vessel, lung, T-cell and erythroid development. KLF2-/- mice die by embryonic day 14.5 (E14.5), due to hemorrhaging and heart failure. In KLF2-/- embryos, ?-like globin gene expression is reduced, and E10.5 erythroid cells exhibit abnormal morphology. In this study, other genes regulated by KLF2 were identified by comparing E9.5 KLF2-/- and wild-type (WT) yolk sac erythroid precursor cells, using laser capture microdissection and microarray assays. One hundred and ninety-six genes exhibited significant differences in expression between KLF2-/- and WT; eighty-nine of these are downregulated in KLF2-/-. Genes involved in cell migration, differentiation and development are over-represented in the KLF2-regulated gene list. The SOX2 gene, encoding a pluripotency factor, is regulated by KLF2 in both ES and embryonic erythroid cells. Previous work had identified genes with erythroid-enriched expression in the yolk sac. The erythroid-enriched genes reelin, adenylate cyclase 7, cytotoxic T lymphocyte-associated protein 2 alpha, and CD24a antigen are downregulated in KLF2-/- compared to WT, and are therefore candidates for controlling primitive erythropoiesis. Each of these genes contains a putative KLF2 binding site(s) in its promoter and/or an intron. Reelin has an established role in neuronal development. Luciferase reporter assays demonstrated that KLF2 directly transactivates the reelin promoter in erythroid cells, validating this approach to identify KLF2 target genes.

Redmond, Latasha C.; Dumur, Catherine I.; Archer, Kellie J.; Grayson, Dennis R.; Haar, Jack L.; Lloyd, Joyce A.

2011-01-01

353

Proteolytic enzymes in yolk-sac membrane of quail egg. Purification and enzymatic characterisation.  

PubMed

Degradation of yolk protein is essential for the early development of the avian embryo. In Japanese quail (Coturnix coturnix japonica), proteolysis in the surrounding tissue of the yolk, the yolk-sac membrane, can be inhibited by class-specific inhibitors of cysteine proteinases as well as of aspartic proteinases. Purification of the enzymes leads to one cysteine proteinase and one aspartic proteinase with an apparent molecular mass of 29 kD and 44 kD, respectively. Both enzymes were purified in a two-chain form, although a single-chain form is also present in the homogenate of yolk-sac membrane. The cysteine proteinase was identified by NH2-terminal sequence analysis as well as by kinetic studies as a new cathepsin B from quail. Like mammalian cathepsin B, this avian cathepsin B exhibits two different kinds of proteolytic activity, an endopeptidase activity and a dipeptidyl carboxypeptidase activity. Chicken egg white cystatin, a protein-aceous cysteine proteinase inhibitor, inhibits quail cathepsin B with an equilibrium dissociation constant (Ki) of 3.3 nM. Likewise the aspartic proteinase was identified as a new cathepsin D from quail. This avian cathepsin D has a different processing site to all known mammalian cathepsins D. In quail cathepsin D one NH2-termini is homologous to amino acids 211-230 in mammalian cathepsin D. This is more than 100 amino acids downstream of the mammalian processing site. Comparison of the enzymatic properties of quail and bovine cathepsin D indicate that the different processing site has no influence on the enzymatic properties. PMID:9418005

Gerhartz, B; Auerswald, E A; Mentele, R; Fritz, H; Machleidt, W; Kolb, H J; Wittmann, J

1997-09-01

354

Limb and other postcranial skeletal defects induced by amniotic sac puncture in the mouse.  

PubMed Central

A mouse model for studying the teratogenic effects of amniotic sac puncture has recently been established (MacIntyre et al. 1995), and the anomalies encountered included cleft palate, limb and tail abnormalities, and postural deformities. In order to investigate the underlying mechanism(s) involved, mouse embryos subjected to amniotic sac puncture on day 13 of gestation were examined externally on day 19, then 'cleared' and bulk stained with alizarin red S and Alcian blue to reveal, respectively, their bony and cartilaginous elements. This procedure allowed a comparison to be made between the incidence of soft tissue anomalies of the distal parts of the limbs and the appearance of the underlying skeletal elements. Despite a high incidence of soft tissue (principally digital) anomalies, relatively few skeletal anomalies were encountered. Measurements of intact long bones, and regions of ossification, were made in the major long bones of 'nonexperimental' and 'internal' controls and 'experimental' fetuses that displayed external morphological malformations to establish whether the experimental procedure had a greater effect on the proximal or distal components of the limb skeleton. No significant difference was observed when the ratios of proximal: distal length were compared with those obtained from the control series. The degree of severity of 'clubhand' and 'clubfoot' deformity was determined, and a comparison made between the severity observed on the right and left sides. This analysis revealed that for 'clubhand', the left forelimb was more severely affected than the right forelimb. The incidence of 'clubfoot' deformity was similar between the 2 sides. A possible explanation for this asymmetric effect is provided. An unexpected finding was the abnormal pattern of ossification seen in the sternum of two thirds of the 'experimental' fetuses that displayed external morphological malformations. This abnormal pattern was seen in none of the controls nor in fetuses in the 'experimental' series that displayed no external morphological malformations. Images Fig. 1 Fig. 2 Fig. 3

Chang, H H; Schwartz, Z; Kaufman, M H

1996-01-01

355

The Human First Trimester Gestational Sac Limits Rather than Facilitates Oxygen Transfer to the Foetus—A Review  

Microsoft Academic Search

Oxygen (O2) free radicals are a potential teratologic threat to the foetal tissues and are known to be involved in the pathophysiology of common human pregnancy disorders such as miscarriage and pre-eclampsia. During the first two months of human gestation, the placenta surrounds the whole gestational sac, the villi contain only a few capillaries located mainly within the centre of

E. Jauniaux; B. Gulbis; G. J. Burton

2003-01-01

356

Radiologic–pathologic findings of primary osseous adamantinoma with unusual metastasis to the posterior cul-de-sac in pregnancy  

Microsoft Academic Search

Adamantinoma is a rare primary bone malignancy with a predilection for the tibial cortex. Metastases have been reported to the long bones, lung, pleura and spine. We present a 26-year-old pregnant woman with metastatic disease to the posterior cul-de-sac, lungs, liver and retroperitoneum, which collectively have not been previously reported in a single patient to our knowledge.

Jonathan A. Flug; Luke R. Scalcione; Laleh Hakima; George Ganson; Joseph P. Mazzie; Douglas S. Katz; Michael Brooks

2011-01-01

357

The relationship between time spent in the culs-de-sac of a stylus maze and speed of elimination  

Microsoft Academic Search

Analysis of the records of 30 college students who learned the Warden 10-alley maze to a criterion of three perfect trials in succession leads the author to the following conclusions: (1) An inverse relationship exists between the length of time spent in a cul-de-sac and the difficulty of its elimination. (2) The percentage of time spent in the true path

H. N. Peters; J. A. McGeoch

1935-01-01

358

Freshwater Resources and Saline Water Near the Sac and Fox Nation Tribal Lands, Eastern Lincoln County, Oklahoma.  

National Technical Information Service (NTIS)

The purpose of this report is to describe freshwater resources and evaluate possible sources of high-chloride and high-sulfate concentrations in parts of the aquifer. Data are interpreted to determine (1) whether ground water near the Sac and Fox Nation t...

M. M. Abbott

1998-01-01

359

Molecular dynamics simulations of the hyperthermophilic protein sac7d from Sulfolobus acidocaldarius: contribution of salt bridges to thermostability1  

Microsoft Academic Search

Hyperthermophilic proteins often possess an increased number of surface salt bridges compared with their mesophilic homologues. However, salt bridges are generally thought to be of minor importance in protein stability at room temperature. In an effort to understand why this may no longer be true at elevated temperatures, we performed molecular dynamics simulations of the hyperthermophilic protein Sac7d at 300

Paul I. W. de Bakker; Philippe H. Hunenberger; J. Andrew McCammon

1999-01-01

360

Long-term biomonitoring of lichen and bryophyte biodiversity at Burnham Beeches SAC and global environmental change  

Microsoft Academic Search

Long-term monitoring began 20 years ago at Burnham Beeches Site of Special Interest (SSSI), National Nature Reserve (NNR) and European Special Area of Conservation (SAC) lying 40 km west of London as a consequence of the authorization of an application to extract gravel from an adjacent site lying north of Slough Trading Estate. Dust monitoring (sticky pads) and photographic monitoring,

O. William Purvis; I. Tittley; P. D. Jim Chimonides; Roger Bamber; Peta A. Hayes; Peter W. James; Fred J. Rumsey; Helen Read

2010-01-01

361

Preoperative Coil Embolization to Aortic Branched Vessels for Prevention of Aneurysmal Sac Enlargement Following EVAR: Early Clinical Result  

PubMed Central

Objective: Persistent Type 2 endoleaks (PT2) after endovascular aortic aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA) are associated with increased adverse outcomes, including aneurysmal sac enlargement and rupture. The aim of this study was to report early clinical outcomes of coil embolization (CE) to aortic branched vessels prior to EVAR and assess the effectiveness of this strategy in terms of prevention of sac growth due to PT2. Materials and Methods: Between May 2007 and April 2012, EVAR was performed for 215 cases, divided into two groups (150 cases in Group A, before introduction of CE; 21 in Group B, receiving CE before EVAR). Early clinical outcomes were compared between groups. Results: Fifty percent of cases in Group B had a marked reduction of aneurysmal sac diameter based on multi-detector row computed tomographic angiography (MDCTA) findings at the 6-month follow-up after EVAR, whereas, only 25% of cases in Group A had shrinkage of the aneurysmal sac during the same time period after EVAR. Conclusion: This strategy has the possibility of improving late outcomes of EVAR by reducing endoleak volumes beforehand.

2013-01-01

362

Incorporation of strontium into the calcium carbonate crystals of the endolymphatic sac in the tree frog (Hyla arborea japonica).  

PubMed

Tree frogs were loaded with strontium chloride (SrCl2). The incorporation of strontium metal into the calcium carbonate (CaCO3) crystals located both in the inner ear and in the endolymphatic sac was studied by x-ray microanalysis (XMA) and scanning electron microscopy (SEM). In the inner ear, strontium was not recognized except for traces in a few crystals. When observed by SEM, these crystals had a faceted body and two pointed ends with rather smooth surfaces. However, in the endolymphatic sac, which greatly expands into the spinal canal, strontium was clearly present at every surface of all crystals. Careful examinations by point and line XMA revealed that strontium x-ray counts were highest at the pointed ends and decreased sharply and then gradually toward the equator of the crystals. SEM observations revealed that the crystals in the endolymphatic sac always had rough and irregular surfaces regardless of their shapes and sizes. Calcium was always found in crystals of both organs. Except for calcium and strontium, other elements including sodium and heavier elements were negligible in XMA. These findings suggest that strontium is incorporated into the crystals only in the endolymphatic sac, and the rough-surfaced covering of these crystals reflects newly deposited strontium salt. It seems to indicate that these crystals grow predominantly by accretion. PMID:3619090

Kawamata, S

1987-06-01

363

Evolution of Archosaurian Body Plans: Skeletal Adaptations of an Air-Sac-Based Breathing Apparatus in Birds and Other Archosaurs  

Microsoft Academic Search

Living birds represent the only extant sauropsid group in which pulmonary air sacs pneumatize the postcranial skeleton. Notable in this regard is an extraordinary degree of variability, ranging from species that are completely apneumatic to those characterized by air within the entire postcranial skeleton. Although numerous factors (e.g., body size) have been linked with ''relative'' pneumaticity, comparative studies examining this

PATRICK MICHAEL

364

Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development  

Microsoft Academic Search

In mice, the yolk sac appears to play a crucial role in nourishing the developing embryo, especially during embryonic days (E) 7-10. Lipoprotein synthesis and secre- tion may be essential for this function: embryos lacking apolipoprotein (apo) B or microsomal triglyceride transfer protein (MTP), both of which participate in the assembly of triglyceride-rich lipoproteins, are apparently defective in their ability

Yuko Terasawa; Sylvaine J. Cases; Jinny S. Wong; Haris Jamil; Sumana Jothi; Maret G. Traber; Lester Packer; David A. Gordon; Robert L. Hamilton; Robert V. Farese

365

Ultrafast Forwarding Architecture Using a Single Optical Processor for Multiple SAC-Label Recognition Based on FWM  

Microsoft Academic Search

We propose and demonstrate a novel ultrafast label processor that can recognize multiple spectral amplitude coded (SAC) labels using four wave mixing (FWM) sideband allocation and selective optical filtering. Our proposed solution favors hardware simplicity over bandwidth efficiency in order to achieve ultra- fast label recognition at reasonable cost. Our implementation, unlike all other optical label processing techniques, does not

JosÉ Bernardo Rosas-FernÁndez; Simon Ayotte; Leslie A. Rusch; Sophie LaRochelle

2008-01-01

366

Location and identification of the collagen found in the 14.5-d rat embryo visceral yolk sac  

PubMed Central

The collagens associated with 14.5-d rat visceral yolk sacs were localized and identified by a variety of procedures. Morphological examination showed that both the visceral epithelium and mesothelium rested upon thin basement membranes, whereas the majority of the extracellular matrix consisted of a stroma containing occasional cells and abundant banded fibrils. Immunohistochemistry at the electron microscope level showed that the basement membranes specifically cross- reacted with antibodies directed against mouse basement membrane components, whereas the stroma specifically cross-reacted with antibodies directed against rat type I collagen. Extractions of acellular visceral yolk sacs and subsequent analyses showed that type I collagen components were prevalent. Furthermore, in vitro biosynthetic studies showed only the presence of type I procollagen components (or their conversion products) and alpha-fetoprotein. These findings, taken together with our previous studies on the 14.5-d rat parietal yolk sac, provide us with protein markers for studying the origin of cells in rat parietovisceral yolk sac carcinomas.

1982-01-01

367

[Results of using biocoating by means of the amniotic sac. Communication 2. Biocoating for the treatment of keratitis].  

PubMed

The amniotic sac has recently come into wide use to treat patients with various corneal lesions. Its suture fixation to the conjunctiva has proven to be inadequate, which limits its therapeutic effect. It is not quite expedient to use a donor corneoscleral flap for amniotic sac fixation in the existing shortage of a plastic material for keratoplasty. Longer retention of the amniotic sac on the involved cornea is achieved by the authors' technology that is to prescarify the ulcerated corneal surface, to set the preserved amniotic sac onto the surface, by grasping the limbal region of a graft, to place a ring-shaped donor layer or full-thickness corneoscleral flap cut out of a donor eye from which a corneal graft has been previously taken to be transplanted to another patient, to fix a ring-shaped flap together with the amnion with 8-00 interrupted sutures to the conjunctiva and episclera of a patient's eye. Twenty-nine patients with long non-healing corneal surface layer defect were operated on. Ten days after biocoat removal, complete corneal epithelization was revealed in 21 patients, defect substantially reduced in 8 patients, in them complete epithelization occurred in the outpatient setting following 5-7 days. PMID:19205395

Stepanov, V K; Masaud, Iu; Ivanova, O V

368

Dialogue management in the dutch ARISE train timetable information system  

Microsoft Academic Search

We present the evaluation of the most recent version of theDutch ARISE train timetable information system. The originalversion of this spoken dialogue system has been adjustedaccording to the findings of two user tests [1,2]. The newversion applies a mixture of implicit and explicit confirmationof information items, based on confidence measures. Inaddition, the negotiation part of the dialogue tells the userexplicitly

Janienke Sturin; Els den Os; Lou Boves

1999-01-01

369

Field trials of the Italian ARISE train timetable system  

Microsoft Academic Search

This paper reports results from two field trials of the CSELT Arise spoken dialogue system in the Italian railway call centre FS-Informa. The system provides voice-driven access to railway timetable for the major Italian and some European cities. On the basis of the initial experiences we have been able to integrate the automatic system in the architecture of a typical

Paolo Baggia; Giuseppe Castagneri; Morena Danieli

2000-01-01

370

Combinatorial Problems Arising in SNP and Haplotype Analysis  

Microsoft Academic Search

It is widely anticipated that the study of variation in the human genome will provide a means of predicting riskof a variety of complex diseases. This paper presents a number of algorithmic and com- binatorial problems that arise when studying a very common form of genomic variation, single nucleotide polymorphisms (SNPs). We review recent results and present challenging open problems.

Bjarni V. Halldórsson; Vineet Bafna; Nathan Edwards; Ross Lippert; Shibu Yooseph; Sorin Istrail

2003-01-01

371

Transcultural knowledge and skills transfer: issues arising from evaluation processes  

Microsoft Academic Search

The transfer of knowledge, policy and practice between nations increasingly involves knowledge of the theory and practice of evaluation. This article examines issues arising from the transcultural evaluation of a drug and alcohol misuse knowledge and skills transfer programme for nurses, nurse teachers and medical staff in the narcology service in St Petersburg, Russia that ran between 1995 and 2004.

Anita J. Green; David G. Holloway

2007-01-01

372

A Demonstration of the System Assessment Capability (SAC) Rev. 1 Software for the Hanford Remediation Assessment Project  

SciTech Connect

The System Assessment Capability (SAC) is a suite of interrelated computer codes that provides the capability to conduct large-scale environmental assessments on the Hanford Site. Developed by Pacific Northwest National Laboratory for the Department of Energy, SAC models the fate and transport of radioactive and chemical contaminants, starting with the inventory of those contaminants in waste sites, simulating transport through the environment, and continuing on through impacts to the environment and humans. Separate modules in the SAC address inventory, release from waste forms, water flow and mass transport in the vadose zone, water flow and mass transport in the groundwater, water flow and mass transport in the Columbia River, air transport, and human and ecological impacts. The SAC supports deterministic analyses as well as stochastic analyses using a Monte Carlo approach, enabling SAC users to examine the effect of uncertainties in a number of key parameters. The initial assessment performed with the SAC software identified a number of areas where both the software and the analysis approach could be improved. Since that time the following six major software upgrades have been made: (1) An air pathway model was added to support all-pathway analyses. (2) Models for releases from glass waste forms, buried graphite reactor cores, and buried naval reactor compartments were added. (3) An air-water dual-phase model was added to more accurately track the movement of volatile contaminants in the vadose zone. (4) The ability to run analyses was extended from 1,000 years to 10,000 years or longer after site closure. (5) The vadose zone flow and transport model was upgraded to support two-dimensional or three-dimensional analyses. (6) The ecological model and human risk models were upgraded so the concentrations of contaminants in food products consumed by humans are produced by the ecological model. This report documents the functions in the SAC software and provides a number of example applications for Hanford problems. References to theory documents and user guides are provided as well as links to a number of published data sets that support running analyses of interest to Hanford cleanup efforts.

Eslinger, Paul W.; Kincaid, Charles T.; Nichols, William E.; Wurstner, Signe K.

2006-11-06

373

Pathologic Characteristics of NUT Midline Carcinoma Arising in the Mediastinum  

PubMed Central

NUT midline carcinomas (NMC) comprise a group of highly aggressive tumors that have been reported primarily in the head, neck, and mediastinum of younger individuals. These tumors overexpress the nuclear protein in testis (NUT), most commonly due to a chromosomal translocation that fuses the NUT gene on chromosome 15 with the BRD4 gene on chromosome 19. Although the earliest recognized cases were described in the thymus or mediastinum, an extensive survey for NMC among malignant thymic or other mediastinal neoplasms has not been reported. We examined NUT expression in 114 cases of poorly differentiated carcinomas or unclassified mediastinal malignancies using a clinically validated NUT-specific monoclonal antibody. Four of 114 (3.5%) cases showed nuclear NUT expression. A NUT translocation was confirmed by fluorescence in situ hybridization (FISH) in 3 of these cases. These tumors arose in two male and two female adults with a median age of 50 (range 28 to 68). Three of the tumors were originally diagnosed as undifferentiated epithelioid or round cell malignant neoplasms; one tumor contained focal squamous differentiation and was originally diagnosed as a poorly differentiated squamous carcinoma of probable thymic origin. We find that the incidence of NMC within the mediastinum, particularly amongst undifferentiated tumors, is similar to that reported at other anatomic sites. NMC should be considered in the differential diagnosis of any poorly-differentiated epithelioid mediastinal tumor, regardless of age.

Evans, Andrew G.; French, Christopher A.; Cameron, Michael J.; Fletcher, Christopher D.; Jackman, David M.; Lathan, Christopher S.; Sholl, Lynette M.

2012-01-01

374

Pathologic characteristics of NUT midline carcinoma arising in the mediastinum.  

PubMed

NUT midline carcinomas (NMCs) comprise a group of highly aggressive tumors that have been reported primarily in the head, neck, and mediastinum of younger individuals. These tumors overexpress the nuclear protein in the testis (NUT), most commonly due to a chromosomal translocation that fuses the NUT gene on chromosome 15 with the BRD4 gene on chromosome 19. Although the earliest recognized cases were described in the thymus or mediastinum, an extensive survey for NMCs among malignant thymic or other mediastinal neoplasms has not been reported. We examined NUT expression in 114 cases of poorly differentiated carcinomas or unclassified mediastinal malignancies using a clinically validated NUT-specific monoclonal antibody. Four of 114 (3.5%) cases showed nuclear NUT expression. A NUT translocation was confirmed by fluorescence in situ hybridization in 3 of these cases. These tumors arose in 2 men and 2 women with a median age of 50 years (range, 28 to 68 y). Three of the tumors were originally diagnosed as undifferentiated epithelioid or round cell malignant neoplasms; 1 tumor contained focal squamous differentiation and was originally diagnosed as a poorly differentiated squamous carcinoma of probable thymic origin. We find that the incidence of NMC within the mediastinum, particularly among undifferentiated tumors, is similar to that reported at other anatomic sites. NMC should be considered in the differential diagnosis of any poorly differentiated epithelioid mediastinal tumor, regardless of age. PMID:22790861

Evans, Andrew G; French, Christopher A; Cameron, Michael J; Fletcher, Christopher D M; Jackman, David M; Lathan, Christopher S; Sholl, Lynette M

2012-08-01

375

Central Mucoepidermoid Carcinoma Arising in a Maxillary Odontogenic Cyst.  

National Technical Information Service (NTIS)

The mucoepidermoid carcinoma was first described as a distinct clinicopathologic entity by Stewart and others in their classic paper in 1945. The tumor is composed of mucus-secreting cells, epidermoid-type cells, and intermediate cells that presumably may...

P. D. Marano K. S. Hartman

1974-01-01

376

Acinar Cell Carcinoma Arising from an Ectopic Pancreas  

Microsoft Academic Search

We herein report a rare case of ectopic pancreatic acinar cell carcinoma (ACC) which presented as a submucosal tumor of the\\u000a pylorus. A 73-year-old man came to our hospital presenting with epigastralgia. Esophago-gastroduodenal endoscopy showed no\\u000a mucosal lesions, but a submucosal tumor was observed around the pylorus. Abdominal computed tomography revealed two round\\u000a masses. One was located in the pylorus,

Yoshimasa Mizuno; Yasuhiro Sumi; Sho Nachi; Yoshihiro Ito; Tsutomu Marui; Shigetoyo Saji; Hirokazu Matsutomo

2007-01-01

377

Epithelial–myoepithelial carcinoma arising in the nasal cavity  

Microsoft Academic Search

This study documents a case of an epithelial–myoepithelial carcinoma (EMC) in the left nasal cavity. A 70-year-old woman who presented with recurrent epistaxis of the left nasal nostril of 3 months duration was found to have a polypoid tumor in the left nasal cavity. A computed tomography (CT) scan revealed a tumor to occupy the left inferior and middle nasal

Koji Yamanegi; Nobuhiro Uwa; Mitsuyoshi Hirokawa; Hideki Ohyama; Masaki Hata; Naoko Yamada; Koichi Ogino; Kunichika Toh; Tomonori Terada; Akio Tanaka; Masafumi Sakagami; Nobuyuki Terada; Keiji Nakasho

2008-01-01

378

Brain tumors.  

PubMed Central

Recent advances in experimental tumor biology are being applied to critical clinical problems of primary brain tumors. The expression of peripheral benzodiazepine receptors, which are sparse in normal brain, is increased as much as 20-fold in brain tumors. Experimental studies show promise in using labeled ligands to these receptors to identify the outer margins of malignant brain tumors. Whereas positron emission tomography has improved the dynamic understanding of tumors, the labeled selective tumor receptors with positron emitters will enhance the ability to specifically diagnose and greatly aid in the pretreatment planning for tumors. Modulation of these receptors will also affect tumor growth and metabolism. Novel methods to deliver antitumor agents to the brain and new approaches using biologic response modifiers also hold promise to further improve the management of brain tumors. Images

Black, K. L.; Mazziotta, J. C.; Becker, D. P.

1991-01-01

379

Colonic Adenocarcinoma Arising from Gastric Heterotopia: A Case Study  

PubMed Central

Heterotopic gastric mucosa occurs in all areas of the gastrointestinal tract including the nasopharynx, tongue, esophagus, small intestine, colon, and rectum. Gastric heterotopia of the large bowel is infrequent, and most cases have been reported in the rectum. Review of the literature has revealed only eight cases involving the colon proximal to the rectum. Little is known of the natural history of gastric heterotopias, except that. It usually presents with gastrointestinal bleeding, though other serious complications such as bowel perforation, intussusceptions, and fistula formation, are possible. Further, it is unclear whether heterotopic gastric mucosa progresses to malignancy. Herein, we describe a case of adenocarcinoma of the transverse colon arising from gastric heterotopia. To the best of our knowledge, this is the first report of adenocarcinoma arising from heterotopic gastric mucosa in the colon.

Ko, Hyoungsuk; Park, Shin Young; Cha, Eun Jung

2013-01-01

380

From genetic to structural characterization of a new class of RNA-binding domain within the SacY/BglG family of antiterminator proteins.  

PubMed Central

SacY is the prototype of a family of regulatory proteins able to prevent transcription termination. It interacts with a 29 nucleotide RNA sequence able to fold into a stem-loop structure and partially overlapping with a terminator sequence located in the 5' leader mRNA region of the gene it controls. We show here that the N-terminal fragment of SacY, SacY(1-55), and the corresponding fragments of other members of the family have antiterminator activities with efficiency and specificity identical to those of the full-length proteins. In vitro, this activity correlates with the specific affinity of SacY(1-55) for its RNA target. UV melting experiments demonstrate that SacY(1-55) binding stabilizes the RNA target structure. The NMR solution structure of SacY(1-55) is very similar to that obtained in the crystal (van Tilbeurgh et al., 1997): the peptide is folded as a symmetrical dimer without any structural homology with other RNA-binding domains yet characterized. According to a preliminary NMR analysis of the SacY(1-55)-RNA complex, the protein dimer is not disrupted upon RNA binding and several residues implicated in RNA recognition are located at the edge of the dimer interface. This suggests a new mode of protein-RNA interaction.

Manival, X; Yang, Y; Strub, M P; Kochoyan, M; Steinmetz, M; Aymerich, S

1997-01-01

381

Coastal wetland subsidence arising from local hydrologic manipulations  

Microsoft Academic Search

Twenty-three estimates of soil subsidence rates arising under the influence of local hydrologic changes from flap-gates, weirs,\\u000a dikes, and culverts in tidal wetlands were compared to 75 examples of subsidence in drained agricultural wetlands. The induced\\u000a subsidence rates from these hydrologic modifications in tidal wetlands can continue for more than 100 years, and range between\\u000a 1.67 to 0.10 cm yr?1

R. Eugene Turner

2004-01-01

382

Mucoepidermoid carcinoma arising in the accessory parotid gland  

Microsoft Academic Search

A rare case of a 9-year-old female with mucoepidermoid carcinoma arising in the accessory parotid gland is reported. She had complained of a painless and round mass of the left cheek for a duration of 14 months. Sialography, ultrasonography, CT scan and MRI were performed preoperatively. Sialography revealed a small duct separating from the Stensen’s duct. CT and MRI showed

Toshio Yoshihara; Saori Suzuki; Koichi Nagao

1999-01-01

383

Squamous cell carcinoma arising in a ciliated hepatic foregut cyst: case report and literature review.  

PubMed

We report a case of squamous cell carcinoma arising in a ciliated hepatic foregut cyst (CHFC) in the left lobe of the liver in a 60-year-old woman. Gross examination revealed an irregular, partially encapsulated, smooth tumor mass with multiple cystic areas, 3-5mm in size. Microscopically, the lining of the microcysts was composed of ciliated columnar epithelium with scattered goblet cells. Multiple foci of squamous metaplasia of the columnar epithelium were observed, which showed areas with dysplastic changes and other areas with carcinomatous transformation. Our case also showed an inconspicuous or absent smooth muscle layer. This case suggests that CHFC deserves careful clinical follow-up and differential diagnosis to exclude malignant transformation. Total surgical excision of the cyst is recommended. PMID:19410383

Zhang, Xiangsheng; Wang, Zhen; Dong, Yanjun

2009-05-02

384

Bartholin's abscess arising within hidradenoma papilliferum of the vulva: a case report  

PubMed Central

Background Hidradenoma papilliferum is an uncommon, benign, cystic, papillary tumor that occurs almost exclusively in the female anogenital region. Bartholin's abscess is also an anogenital cystic lesion caused by obstruction of Bartholin's duct with an overlying infection. Concomitant presentation of Bartholin's abscess and Hidradenoma papilliferum is unique. Case presentation A 43-year-old African American woman presented with a painful cystic mass on the left labia majora. A preoperative diagnosis of Bartholin's abscess was made. During excision and draining, an additional tan-brown dermal nodule was removed which demonstrated histological features of Hidradenoma papilliferum. Conclusion We present what we believe to be the first case of Bartholin's abscess arising in hidradenoma papilliferum and its clinical significance.

Docimo, Salvatore; Shon, Wonwoo; Elkowitz, David E

2008-01-01

385

Tumors of the thymus.  

PubMed

Thymic neoplasms are a common cause of an anterior mediastinal mass and may be benign or malignant. Thymic cysts are congenital or acquired and may be associated with a thymic malignancy. True thymic hyperplasia and thymic lymphoid hyperplasia may enlarge the thymus and simulate a neoplasm. Thymoma and thymic carcinoma are epithelial malignancies with distinct clinicopathologic features. Thymic carcinoid is a rare aggressive neuroendocrine malignancy associated with multiple endocrine neoplasia 1. Thymolipoma is a benign neoplasm. Hodgkin and non-Hodgkin lymphoma may primarily or secondarily involve the thymus. Primary mediastinal germ cell tumors may arise primarily within the thymus and include mature teratoma, seminoma, and non-seminomatous malignant germ cell tumors. PMID:10404501

Strollo, D C; Rosado-de-Christenson, M L

1999-07-01

386

Quantitative data on blood flow during tumor PDT obtained by laser Doppler spectroscopy in the hen's egg test system  

NASA Astrophysics Data System (ADS)

Oxygen supply is the most important requirement of type II photodynamic reactions. Prerequisite in photodynamic tumor therapy is an intact tumor blood flow during irradiation. Most photosensitizers destroy tumor vessels due to accumulation in endothelial cells. As a prerequisite to develop novel photosensitizing drugs an in-vivo test system is required to quantitatively assess for inertness of those sensitizers to the blood supply. We adapted and further developed a system capable of measuring the relative oxygen supply to heterotransplanted tumors on the yolk sac membrane (YSM) of fertilized chicken eggs.

Vervoorts, Anja; Rood, H. A.; Klotz, Marcus; Moser, Joerg G.; Rosenbruch, Martin

1995-01-01

387

Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis.  

PubMed

Hepatocellular adenomas (HCA) have been recently identified as a heterogeneous group, differing based on genotypic as well as morphological characteristics. HCA are most frequently found in women on oral contraception. A type of HCA, inflammatory HCA, is also known as telangiectatic HCA and was previously referred to as telangiectatic focal nodular hyperplasia. We present the first case of HCA arising from the liver with primary sclerosing cholangitis (PSC). This case is a 30-year-old man with a past medical history of PSC, ulcerative colitis and diabetes mellitus. A routine ultrasonography for PSC detected the gradually enlarged intrahepatic mass. Liver biopsy could reveal the diagnosis of telangiectatic/ inflammatory HCA by morphological and immunohistochemical analyses. Partial hepatectomy was performed and the resected liver was pathologically diagnosed as the telangiectatic/inflammatory HCA arising in PSC. This is the first case report of such an association and here we review the current developments and published work of this rare tumor and the association with an activated inflammatory related tumorogenic pathway and PSC. PMID:22568458

Maylee, Hsu; Harada, Kenichi; Igarashi, Saya; Tohda, Gen; Yamamoto, Makoto; Ren, Xiang Shan; Osawa, Takeshi; Hasegawa, Yasuhiro; Takahashi, Norio; Nakanuma, Yasuni

2012-06-01

388

Hypothalamic tumor  

MedlinePLUS

... as surgery, with less risk to surrounding tissue. Brain swelling caused by a tumor may need to be treated with steroids. Hypothalamic tumors may produce hormones or affect hormone production, leading to imbalances that ...

389

Oligodendroglial tumors.  

PubMed

Oligodendroglial tumors represent approximately 4-7% of all gliomas; however, in some series the incidence has been reported to be as high as 10-20% because of improved histological appreciation and recently recognized molecular signatures. Oligodendroglial tumors are classified as being low-grade oligodendroglial tumors, high-grade anaplastic oligodendroglial tumors or mixed oligo-astrocytic tumors. The mixed tumors can again be low-grade or high-grade. The recent European Organization for Research and Treatment of Cancer and Radiation Therapy Oncology Group randomized trials have provided level 1 evidence regarding the best management of these tumors. This review provides an overview of oligodendroglial tumors and discusses contemporary and evolving treatment strategies. PMID:16623651

Chowdhary, Sajeel; Chamberlain, Marc C

2006-04-01

390

Carcinoid Tumor  

MedlinePLUS

... based on how a tumor processes and makes serotonin (5-HT, a neurotransmitter involved in behavior and ... typical lung carcinoid tumor causes high levels of serotonin and chromogranin-A in the blood and high ...

391

Expression of the Bacillus subtilis sacB gene leads to sucrose sensitivity in the gram-positive bacterium Corynebacterium glutamicum but not in Streptomyces lividans.  

PubMed Central

The expression of the structural gene (sacB) encoding Bacillus subtilis levansucrase in two gram-positive soil bacteria, Corynebacterium glutamicum ATCC 13032 and Streptomyces lividans 1326, was investigated. sacB expression in the presence of sucrose is lethal to C. glutamicum but not to S. lividans. While S. lividans secretes levansucrase into the medium, we could show that the enzyme is retained by C. glutamicum cells. Our results imply that the sacB gene can be used as a positive selection system in coryneform bacteria.

Jager, W; Schafer, A; Puhler, A; Labes, G; Wohlleben, W

1992-01-01

392

Urogenital tumors  

SciTech Connect

An overview is provided for veterinary care of urogenital tumors in companion animals, especially the dog. Neoplasms discussed include tumors of the kidney, urinary bladder, prostate, testis, ovary, vagina, vulva and the canine transmissible venereal tumor. Topics addressed include description, diagnosis and treatment.

Weller, R.E.

1994-03-01

393

Does the tumor microenvironment influence radiation-induced apoptosis?  

Microsoft Academic Search

Cytotoxic anti-cancer agents induce apoptosis in tumor and normal tissues. Therefore, it is important to investigate which\\u000a factors determine these apoptotic processes and hence their likely impact on therapeutic gain. Radiation-induced apoptosis\\u000a in tumors may be inhibited due to mutations of apoptotic elements or to tumor microenvironmental conditions arising from vascular\\u000a insufficiency. Tumors typically contain regions of hypoxia, low glucose

Alistair Hunter; Andre Hendrikse; Michael Renan; Raymond Abratt

2006-01-01

394

Urachal mucinous tumor of uncertain malignant potential: a case report.  

PubMed

Urachal mucinous tumor of uncertain malignant potential is very rare and is characterized by a multilocular cyst showing the proliferation of atypical mucin-secreting cells without stromal invasion. As in ovarian and appendiceal borderline tumors, it represents a transitional stage of mucinous carcinogenesis in the urachus. In addition, this tumor may recur locally and develop into pseudomyxoma peritonei. Due to its scarcity and diagnostic challenges, we report a mucinous tumor of uncertain malignant potential arising in the urachus. PMID:23109984

Choi, Jung-Woo; Lee, Ju-Han; Kim, Young-Sik

2012-02-23

395

Urachal Mucinous Tumor of Uncertain Malignant Potential: A Case Report  

PubMed Central

Urachal mucinous tumor of uncertain malignant potential is very rare and is characterized by a multilocular cyst showing the proliferation of atypical mucin-secreting cells without stromal invasion. As in ovarian and appendiceal borderline tumors, it represents a transitional stage of mucinous carcinogenesis in the urachus. In addition, this tumor may recur locally and develop into pseudomyxoma peritonei. Due to its scarcity and diagnostic challenges, we report a mucinous tumor of uncertain malignant potential arising in the urachus.

Choi, Jung-Woo; Lee, Ju-Han

2012-01-01

396

Symptoms of Pediatric Brain or Spinal Cord Tumors  

MedlinePLUS

... tumor in that area. A glioma in the cerebrum is likely to cause headaches, nausea, vomiting, weakness ... astrocytoma (JPA) JPAs can arise from the cerebellum, cerebrum or spinal cord. They have also been found ...

397

Endolymphatic sac morphology after instillation of hyperosmolar hyaluronan in the round window niche.  

PubMed

One hundred and sixty-eight mice were injected with hyaluronan (HA) of varying tonicity in the middle ear and compared with 81 control animals to study the effects of hypertonic solutions in the middle ear on inner ear fluid homeostasis and endolymphatic sac (ES) response. Six hours after 1.9% HA and 4, 6 and 8 h after 4% HA deposition there was a significant increase in the proportion of granule-containing light epithelial cells in the ES as compared with controls indicating an enhanced secretory activity from the epithelial lining. Six, 8 and 10 h after deposition of 4% HA, the ES volume was significantly reduced. The secretory activity and the ability of the ES to vary its volume could be specific responses to dehydration of the inner ear resulting from the high colloid osmotic pressure exerted by concentrated HA. The secretion of high-molecular substances into the ES may serve to keep the ES lumen patent and thus ensure a proper ES function and/or to regulate the intralabyrinthine volume and fluid pressure. Whether the findings may have clinical relevance for Ménière's patients remains to be elucidated. PMID:8291432

Jansson, B; Friberg, U; Rask-Andersen, H

1993-11-01

398

Biochemical changes during development of eggs and yolk-sac larvae of herring and plaice  

NASA Astrophysics Data System (ADS)

Changes in quantities of water, sodium, potassium, lipid and protein were compared in developing eggs and yolk-sac larvae of herring Clupes harengus L., a species with demersal eggs, and plaice Pleuronectes platessa L., a species with pelagic eggs. The principal difference between the two species was the occurrence in herring, but not in plaice of considerable increases in water content and in one or both of the above ions at three distinct stages: at fertilization, during the middle stage of egg development, and in the days immediately after hatching. Newly hatched larvae of the two species differed greatly in water content because of the difference in mass and water content of the yolk, not in the water content of the rest of the body. In herring, there were increases in sodium and potassium which coincided broadly with the increase in water content. These differences are related to the gradual acquisition of buoyancy by herring during this period, comparable with the buoyancy conferred on plaice eggs at spawning by the already hydrated, yolk. Lipid and protein, which contribute little to buoyancy, decreased steadily throughout egg and larval development in both species.

Yin, Mingchen; Craik, J. C. A.

1992-12-01

399

Automatic neck plane detection and 3D geometric characterization of aneurysmal sacs.  

PubMed

Geometric indices defined on intracranial aneurysms have been widely used in rupture risk assessment and surgical planning. However, most indices employed in clinical settings are currently evaluated based on two-dimensional images that inevitably fail to capture the three-dimensional nature of complex aneurysmal shapes. In addition, since measurements are performed manually, they can suffer from poor inter and intra operator repeatability. The purpose of the current work is to introduce objective and robust techniques for the 3D characterization of intracranial aneurysms, while preserving a close connection to the way aneurysms are currently characterized in clinical settings. Techniques for automatically identifying the neck plane, key aneurysm dimensions, shape factors, and orientations relative to the parent vessel are demonstrated in a population of 15 sidewall and 15 terminal aneurysms whose surface has been obtained by two trained operators using both level-set segmentation and thresholding, the latter reflecting typical clinical practice. Automatically-identified neck planes are shown to be in concordance with those manually positioned by an expert neurosurgeon, and automatically-derived geometric indices are shown to be largely insensitive to segmentation method or operator. By capturing the 3D nature of aneurysmal sacs and by minimizing observer variability, our approach allows large retrospective and prospective studies on aneurysm geometric risk factors to be performed using routinely acquired clinical images. PMID:22532324

Piccinelli, Marina; Steinman, David A; Hoi, Yiemeng; Tong, Frank; Veneziani, Alessandro; Antiga, Luca

2012-04-25

400

Transport across endodermal cells of the chick yolk sac during early stages of development.  

PubMed

The endoderm of the chick yolk sac mediates the transfer of materials from the yolk mass to the embryonic circulation. There is little evidence of endocytotic activity in the area pellucida, but the endodermal cells of the area vasculosa possess many microvilli and bristle-coated pits and vesicles, as well as a canalicular system and vacuoles in the apical cytoplasm. Three tracers, horseradish peroxidase, ferritin, and latex spheres, were injected beneath the endoderm of both cultured embryos and embryos in ovo to study the pathway of uptake of extracellular materials. All tracers were sequestered in bristle-coated pits (200-500 nm in diameter) of the endodermal cells of the area vasculosa, but not those in the area pellucida. Both horseradish peroxidase and latex spheres (and probably ferritin) were incorporated into pleomorphic intracellular yolk drops through bristle-coated pits and vesicles, and then into apical vacuoles, which fuse with the intracellular yolk drops. Horseradish peroxidase and ferritin were also found within apical canaliculi. The apical junctions between endodermal cells prevented the intercellular passage of the tracers. A "topping-up" hypothesis is opposed whereby endodermal cells of the area vasculosa continually sequester extracellular yolk material, which is incorporated into a digesting intracellular yolk drop while, at the same time, digested yolk products are being transported across the vascular pole of the endoderm to the extraembryonic circulation and thence to the embryo. PMID:7223677

Mobbs, I G; McMillan, D B

1981-03-01

401

Orbit determination performances using single- and double-differenced methods: SAC-C and KOMPSAT-2  

NASA Astrophysics Data System (ADS)

In this paper, Global Positioning System-based (GPS) Orbit Determination (OD) for the KOrea-Multi-Purpose-SATellite (KOMPSAT)-2 using single- and double-differenced methods is studied. The requirement of KOMPSAT-2 orbit accuracy is to allow 1 m positioning error to generate 1-m panchromatic images. KOMPSAT-2 OD is computed using real on-board GPS data. However, the local time of the KOMPSAT-2 GPS receiver is not synchronized with the zero fractional seconds of the GPS time internally, and it continuously drifts according to the pseudorange epochs. In order to resolve this problem, an OD based on single-differenced GPS data from the KOMPSAT-2 uses the tagged time of the GPS receiver, and the accuracy of the OD result is assessed using the overlapping orbit solution between two adjacent days. The clock error of the GPS satellites in the KOMPSAT-2 single-differenced method is corrected using International GNSS Service (IGS) clock information at 5-min intervals. KOMPSAT-2 OD using both double- and single-differenced methods satisfies the requirement of 1-m accuracy in overlapping three dimensional orbit solutions. The results of the SAC-C OD compared with JPL’s POE (Precise Orbit Ephemeris) are also illustrated to demonstrate the implementation of the single- and double-differenced methods using a satellite that has independent orbit information available for validation.

Hwang, Yoola; Lee, Byoung-Sun; Kim, Haedong; Kim, Jaehoon

2011-01-01

402

Towards a probabilistic approach for DAC and SAC exact reconstruction in hot emission stars  

NASA Astrophysics Data System (ADS)

Spectral lines of hot emission stars show Discrete as well as Satellite Absorption Components (DACs and SACs). Disentangling the line components and identifying the physical mechanisms that produce them is a complex procedure, which is relying on many unknown parameters. The number of components that make up each line is one of the factors that need to be defined before examining the physical procedure producing the line profile. Here we propose a novel probabilistic approach to determine the exact number of line components as well as the statistical characteristics of each line component such as variance of the line or higher statistical moments that affect the shape of the DAC spectrum. This approach is based on the observation that the DAC lines may be treated as random signals which can be considered as superposition of independent signals. The number of independent signals can then be considered equal with the number of the interfered lines that make up the DAC. The determination of the higher statistical moments can be done based on the observation that each of the interfered independent random signals is Gaussian shaped signals in spectral space.

Avlonitis, M.; Pappa, A.

403

Apospory appears to accelerate onset of meiosis and sexual embryo sac formation in sorghum ovules  

PubMed Central

Background Genetically unreduced (2n) embryo sacs (ES) form in ovules of gametophytic apomicts, the 2n eggs of which develop into embryos parthenogenetically. In many apomicts, 2n ES form precociously during ovule development. Whether meiosis and sexual ES formation also occur precociously in facultative apomicts (capable of apomictic and sexual reproduction) has not been studied. We determined onset timing of meiosis and sexual ES formation for 569 Sorghum bicolor genotypes, many of which produced 2n ES facultatively. Results Genotype differences for onset timing of meiosis and sexual ES formation, relative to ovule development, were highly significant. A major source of variation in timing of sexual germline development was presence or absence of apomictic ES, which formed from nucellar cells (apospory) in some genotypes. Genotypes that produced these aposporous ES underwent meiosis and sexual ES formation precociously. Aposporous ES formation was most prevalent in subsp. verticilliflorum and in breeding lines of subsp. bicolor. It was uncommon in land races. Conclusions The present study adds meiosis and sexual ES formation to floral induction, apomictic ES formation, and parthenogenesis as processes observed to occur precociously in apomictic plants. The temporally diverse nature of these events suggests that an epigenetic memory of the plants' apomixis status exists throughout its life cycle, which triggers, during multiple life cycle phases, temporally distinct processes that accelerate reproduction.

2011-01-01

404

[An implantable micro-device using wireless power transmission for measuring aortic aneurysm sac pressure].  

PubMed

In order to detect endoleaks after endovascular aneurysm repair (EVAR), we developed an implantable micro-device based on wireless power transmission to measure aortic aneurysm sac pressure. The implantable micro-device is composed of a miniature wireless pressure sensor, an energy transmitting coil, a data recorder and a data processing platform. Power transmission without interconnecting wires is performed by a transmitting coil and a receiving coil. The coupling efficiency of wireless power transmission depends on the coupling coefficient between the transmitting coil and the receiving coil. With theoretical analysis and experimental study, we optimized the geometry of the receiving coil to increase the coupling coefficient. In order to keep efficiency balance and satisfy the maximizing conditions, we designed a closed loop power transmission circuit, including a receiving voltage feedback module based on wireless communication. The closed loop improved the stability and reliability of transmission energy. The prototype of the micro-device has been developed and the experiment has been performed. The experiments showed that the micro-device was feasible and valid. For normal operation, the distance between the transmitting coil and the receiving coil is smaller than 8cm. Besides, the distance between the micro-device and the data recorder is within 50cm. PMID:24059044

Guo, Xudong; Ge, Bin; Wang, Wenxing

2013-08-01

405

Chorioallantoic and yolk sac placentation in Thrichomys laurentinus (Echimyidae) and the evolution of hystricognath rodents.  

PubMed

The evolutionary history of Hystricognathi is associated with major transformations in their placental system. Data so far indicate that key characters are independent from size dimensions in medium to very large species. To better understand the situation in smaller species, we analyzed placental development in a spiny rat, Thrichomys laurentinus. Fourteen individuals ranging from early implantation to near term were investigated by histology, immunohistochemistry, proliferation activity and electron microscopy. Placentation in Thrichomys revealed major parallels to the guinea pig and other hystricognath rodents with respect to the early and invasive implantation, the process of trophoblast invasion, the internal organization of the labyrinth and the trophospongium as well as the establishment of the complete inverted yolk sac placenta. In contrast to systematically related small-sized species, the placental regionalization in Thrichomys was characterized by a remarkable lobulated structure and associated growing processes. Reverse to former perspectives, these conditions represented ancient character states of hystricognaths. The subplacenta was temporarily supplied by both the maternal and fetal blood systems, a rare condition among hystricognaths. The extraplacental trophoblast originating from the subplacenta was partly proliferative in mid gestation. In conclusion, the presented results indicated that only minor variations occurred in small-sized hystricognath species, independent of their systematic interrelationships. Previous views were supported that placentation in hystricognaths followed an extraordinary stable pattern, although the group had distinct habitats in South America and Africa that were separated 30-40 million years ago. PMID:21898786

Franco de Oliveira, Moacir; Favaron, Phelipe Oliveira; Ambrósio, Carlos Eduardo; Miglino, Maria Angélica; Mess, Andrea Maria

2011-09-06

406

Buckling Instability in Growing Tumor Spheroids  

NASA Astrophysics Data System (ADS)

A growing tumor is subjected to intrinsic physical forces, arising from the cellular turnover in a spatially constrained environment. This work demonstrates that such residual solid stresses can provoke a buckling instability in heterogeneous tumor spheroids. The growth rate ratio between the outer shell of proliferative cells and the inner necrotic core is the control parameter of this instability. The buckled morphology is found to depend both on the elastic and the geometric properties of the tumor components, suggesting a key role of residual stresses for promoting tumor invasiveness.

Ciarletta, P.

2013-04-01

407

Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase  

PubMed Central

In the Golgi apparatus, lipid homeostasis pathways are coordinated with the biogenesis of cargo transport vesicles by phosphatidylinositol 4-kinases (PI4Ks) that produce phosphatidylinositol 4-phosphate (PtdIns4P), a signaling molecule that is recognized by downstream effector proteins. Quantitative analysis of the intra-Golgi distribution of a PtdIns4P reporter protein confirms that PtdIns4P is enriched on the trans-Golgi cisterna, but surprisingly, Vps74 (the orthologue of human GOLPH3), a PI4K effector required to maintain residence of a subset of Golgi proteins, is distributed with the opposite polarity, being most abundant on cis and medial cisternae. Vps74 binds directly to the catalytic domain of Sac1 (KD = 3.8 ?M), the major PtdIns4P phosphatase in the cell, and PtdIns4P is elevated on medial Golgi cisternae in cells lacking Vps74 or Sac1, suggesting that Vps74 is a sensor of PtdIns4P level on medial Golgi cisternae that directs Sac1-mediated dephosphosphorylation of this pool of PtdIns4P. Consistent with the established role of Sac1 in the regulation of sphingolipid biosynthesis, complex sphingolipid homeostasis is perturbed in vps74? cells. Mutant cells lacking complex sphingolipid biosynthetic enzymes fail to properly maintain residence of a medial Golgi enzyme, and cells lacking Vps74 depend critically on complex sphingolipid biosynthesis for growth. The results establish additive roles of Vps74-mediated and sphingolipid-dependent sorting of Golgi residents.

Wood, Christopher S.; Hung, Chia-Sui; Huoh, Yu-San; Mousley, Carl J.; Stefan, Christopher J.; Bankaitis, Vytas; Ferguson, Kathryn M.; Burd, Christopher G.

2012-01-01

408

Emergence of a glomus-like body in the human yolk sac: a microanatomical analysis of its structure.  

PubMed

Since the last decade the Yolk sac (YS) has been a topic of increasing interest due to the growing use of high-resolution sonography in early determination of pregnancy. Human YS shape and diameter are indicators of viability of pregnancy during the early embryonic period. Nevertheless, the major interest concerns the vital function it plays in early embryo growth and development. Two compartments are recognized in this organ: the yolk sac proper and the vitelline stalk. In this study we report the identification and partial characterization of a glomus-like body in the wall of the secondary YS in humans. A detailed structural description is also presented on the time course of formation of this new structure, at precisely sequential stages between 4-8 wk post-conception. The significance of this new compartment on the YS function is analyzed. Light and scanning electron microscopy were used to investigate the microstructure of the YS and the vitelline stalk during the first 8 wk of development. Ten YSs were collected from embryos (aged between 24-50 days) obtained from emergency salpingectomies due to tubal ectopic pregnancy. From 5 wk onward a new structure was observed in the YS located near the apex of the pear-shaped yolk vesicle and closed to the connecting stalk. We designate this differentiation as glomus-like body. This structure is 1-1.5 mm long and merged from a pocket-like structure of the extraembryonic splanchnic mesoderm of the YS wall. It likely represents an area of convergence of the vascular network of the YS wall. Our findings underline the remarkable complexity of the human secondary yolk sac during early development. The detailed description of the microanatomy of this vital organ is of theoretical and practical interest in order to unravel the mechanisms used by the yolk sac to transport nutrients to the embryo. PMID:16101035

Pereda, J; Corral, E; Franchitto, G

2005-01-01

409

Does Additional Discectomy and the Degree of Dural Sac Compression Influence the Outcome of Decompressive Surgery for Lumbar Spinal Stenosis?  

Microsoft Academic Search

Summary  ¶?The discussion regarding factors that reliably predict the long-term surgical results in patients with lumbar spinal stenosis\\u000a is still going on. This retrospective study analyses the relation between the dimensions of the dural sac and patients' clinical\\u000a status before and after decompressive operations performed with or without additional discectomy.\\u000a \\u000a ?The type of surgery performed in 134 patients and the dural

A. F. Aliashkevich; R. A. Kristof; J. Schramm; D. Brechtelsbauer

1999-01-01

410

The accuracy of the rectovaginal examination in detecting cul-de-sac disease in patients under general anaesthesia  

Microsoft Academic Search

BACKGROUND: The rectovaginal examination is frequently used as an adjunct to a bimanual examination. The accuracy of rectovaginal examination in detecting cul-de-sac disease under ideal circumstances of the operating room was studied. METHODS: Fifty-two attending physicians and 30 residents were selected on experience and immediate availability to evaluate the presence of uterosacral nodularity and external rectal compression on 140 women

K. G. Dragisic; L. A. Padilla; M. P. Mila

2003-01-01

411

Preliminary analysis of the Aquarius\\/SAC-D Microwave Radiometer (MWR) antenna temperature: Possible antenna pattern issue  

Microsoft Academic Search

The Microwave Radiometer (MWR) flying on the Aquarius\\/SAC-D satellite is a Dicke radiometer operating at 23.8 and 36.5 GHz that was developed by the Argentine Space Agency CONAE. This instrument complements Aquarius (NASA's L-band radiometer\\/scatterometer) by providing simultaneous spatially collocated environmental measurements such as oceanic wind speed for roughness correction and rain rate for flagging corrupted salinity retrievals. This paper

Spencer Farrar; W. Linwood Jones

2012-01-01

412

Biochemical Responses of Fish Sac Fry and a Primary Cell Culture of Fish Hepatocytes Exposed to Polychlorinated Naphthalenes  

Microsoft Academic Search

.   Chlorinated naphthalenes are planar halogenated aromatic compounds, which are widespread in the environment. Knowledge of\\u000a their biochemical and toxicological actions in aquatic biota is, however, limited. The objective of this study was to assess\\u000a the toxicity of highly chlorinated naphthalene congeners found in the aquatic environment on fish sac fry and to study their\\u000a effects on xenobiotic metabolizing enzymes

M. Pesonen; P. Teivainen; J. Lundström; E. Jakobsson; L. Norrgren

2000-01-01

413

HoxB4 Confers Definitive Lymphoid-Myeloid Engraftment Potential on Embryonic Stem Cell and Yolk Sac Hematopoietic Progenitors  

Microsoft Academic Search

The extent to which primitive embryonic blood progenitors contribute to definitive lymphoid-myeloid hematopoiesis in the adult remains uncertain. In an effort to characterize factors that distinguish the definitive adult hematopoietic stem cell (HSC) and primitive progenitors derived from yolk sac or embryonic stem (ES) cells, we examined the effect of ectopic expression of HoxB4, a homeotic selector gene implicated in

Michael Kyba; Rita C. R. Perlingeiro; George Q. Daley

2002-01-01

414

Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase.  

PubMed

In the Golgi apparatus, lipid homeostasis pathways are coordinated with the biogenesis of cargo transport vesicles by phosphatidylinositol 4-kinases (PI4Ks) that produce phosphatidylinositol 4-phosphate (PtdIns4P), a signaling molecule that is recognized by downstream effector proteins. Quantitative analysis of the intra-Golgi distribution of a PtdIns4P reporter protein confirms that PtdIns4P is enriched on the trans-Golgi cisterna, but surprisingly, Vps74 (the orthologue of human GOLPH3), a PI4K effector required to maintain residence of a subset of Golgi proteins, is distributed with the opposite polarity, being most abundant on cis and medial cisternae. Vps74 binds directly to the catalytic domain of Sac1 (K(D) = 3.8 ?M), the major PtdIns4P phosphatase in the cell, and PtdIns4P is elevated on medial Golgi cisternae in cells lacking Vps74 or Sac1, suggesting that Vps74 is a sensor of PtdIns4P level on medial Golgi cisternae that directs Sac1-mediated dephosphosphorylation of this pool of PtdIns4P. Consistent with the established role of Sac1 in the regulation of sphingolipid biosynthesis, complex sphingolipid homeostasis is perturbed in vps74? cells. Mutant cells lacking complex sphingolipid biosynthetic enzymes fail to properly maintain residence of a medial Golgi enzyme, and cells lacking Vps74 depend critically on complex sphingolipid biosynthesis for growth. The results establish additive roles of Vps74-mediated and sphingolipid-dependent sorting of Golgi residents. PMID:22553352

Wood, Christopher S; Hung, Chia-Sui; Huoh, Yu-San; Mousley, Carl J; Stefan, Christopher J; Bankaitis, Vytas; Ferguson, Kathryn M; Burd, Christopher G

2012-05-02

415

Aneurysm Sac Pressure Measurement with Minimally Invasive Implantable Pressure Sensors: An Alternative to Current Surveillance Regimes after EVAR?  

Microsoft Academic Search

Current protocols for surveillance after endovascular repair (EVAR) of abdominal aortic aneurysms are mostly based on costly\\u000a and time-consuming imaging procedures and aim to detect adverse events such as graft migration, endoleaks or aneurysm sac\\u000a enlargement. These imaging procedures are either associated with radiation exposure to the patients or may be harmful to the\\u000a patient due to the use of

Fabian Springer; Rolf W. Günther; Thomas Schmitz-Rode

2008-01-01

416

A Semi-Distributed Hydrologic Model for Stream Flow Simulation Using the Sacramento Soil Moisture Accounting Model (SAC-SMA)  

NASA Astrophysics Data System (ADS)

Distributed hydrologic modeling is currently viewed as a potential pathway to improve streamflow simulations regarding the sensitivity of runoff predictions to spatial and temporal variability of precipitation, land use, and soil properties. The US National Weather Service (NWS) started Distributed Model Intercomparison Project (DMIP) to guide NWS's distributed modeling research. In our participation of DMIP-2 activity, a semi-distributed version of the Sacramento Soil Moisture Accounting Model (SAC-SMA) was used to conduct hourly streamflow simulations. This model uses sub-basins as the computational elements of rainfall-runoff modeling. Each sub-basin consists of a lumped SAC-SMA to generate the response components of the runoff. Fast response components are routed over the hillslopes using the unit hydrograph of the sub-basin outlet. Slow response components bypass the hillslopes and are added directly to the sub-basin outlet. Then, a sub-basin-to-sub-basin channel routing is done using kinematic wave routing method. The Illinois River basin at South of Siloam Spring, AR is chosen as the study test basin. Eleven years of grid-based multi-sensor (NEXRAD+gauge) precipitation dataset are used for the calibration and verification periods. Weekly adjustment factors to account for vegetation type and cover are estimated using Global Vegetation Fraction (GVF) product from NOAA/NESDIS/STAR to produce PET demand for the watershed modeling. Several calibration scenarios are tested using the Shuffled Complex Evolution Method (Duan et al, 1992) and Multi Step Automatic Calibration Scheme (Hogue et al, 2000). Results of different calibration scenarios, besides simulations of a priori parameters of the SAC-SMA model (Koren et al, 2000) are shown. The results show that the semi-distributed version of the SAC-SMA has the potential to improve the streamflow simulations.

Khakbaz, B.; Hsu, K.; Sorooshian, S.

2007-12-01

417

Proposal of an Italian experiment for the mission SAC-B--ISENA: imaging particle spectrometer for energetic neutral atoms  

NASA Astrophysics Data System (ADS)

We propose to perform in situ measurements of precipitating and escaping energetic neutral atoms (ENA) of energies between approximately 5 and 200 keV. The interface characteristics of this new type of instrument, named ISENA (Imaging particle Spectrometer for Energetic Neutral Atoms), are consistent with the SAC-B spacecraft specifications, so that it could be included in its scientific payload. The main technical properties of this experiment are here briefly described.

Orsini, Stefano; Candidi, M.; Maggi, M.; Hsieh, Ke C.; Curtis, Charles C.; Hudor, A. M.; Livi, S.; Wilken, B.; Daglis, I. A.; Flamini, Enrico; Negri, Barbara; Tinsley, Brian A.; Gruntman, Michael A.

1992-06-01

418

Investigation of mechanical shock testing of lead-free SAC solder joints in fine pitch BGA package  

Microsoft Academic Search

The lead-free Sn–Ag–Cu (SAC 305\\/405) solder that replaced the tin–lead eutectic solder tends to be more brittle in nature due to high stiffness and excessive solder interfacial reactions. This leads to higher occurrences of solder joints failure during surface mount assembly and handling operations as a result of PCB bending, shock impact and drop. In this work, mechanical tests simulating

Y. T. Chin; P. K. Lam; H. K. Yow; T. Y. Tou

2008-01-01

419

Mucin-producing adenocarcinoma arising in an atrial myxoma.  

PubMed

We describe the unique autopsy findings of a patient who died of a metastasizing giant right atrial adenocarcinoma containing few areas of typical myxoma. That no mucin-producing extracardiac tumor was detected pointed to the atrial adenocarcinoma as being the primary. We hypothesize that the adenocarcinoma may have developed from coexistent bland glandular structures within the myxoma. PMID:22464912

Berger, Martin D; Schneider, Jakob; Ballmer, Peter E; Eckhardt, Boris P; Dommann-Scherrer, Corina

2012-03-29

420

Low-grade fibromyxoid sarcoma arising in the big toe.  

PubMed

Low-grade fibromyxoid sarcoma (LGFMS) is a rare neoplasm commonly affecting young adults and typically arising in the somatic soft tissue of the proximal extremities. Its occurrence within the big toe is exceedingly rare. A 43-year-old man had surgery on a mass located in the big toe, which was first noted 6 months previously. Histological examination revealed LGFMS. One year after surgery, the patient is alive with no evidence of disease. Low-grade fibromyxoid sarcoma is a rare neoplasm that should be considered in the differential diagnosis of spindle cell neoplasms of the foot. PMID:21297533

Kaoutar, Znati; Benlemlih, Amal; Taoufiq, Harmouch; Laila, Chbani; Hinde, Elfatemi; Bennis, Sanae; Afaf, Amarti

2011-03-01

421

Electrostatic repulsion-driven crystallization model arising from filament networks  

NASA Astrophysics Data System (ADS)

The crystallization of bundles in filament networks interacting via long-range repulsions in confinement is described by a phenomenological model. The model demonstrates the formation of the hexagonal crystalline order via the interplay of the confinement potential and the filament-filament repulsion. Two distinct crystallization mechanisms in the short- and large- screening length regimes are discussed, and the phase diagram is obtained. Simulation of large bundles predicts the existence of topological defects within the bundled filaments. This electrostatic repulsion-driven crystallization model arising from studying filament networks can even find a more general context extending to charged colloidal systems.

Yao, Zhenwei; Olvera de la Cruz, Monica

2013-04-01

422

A dilogarithmic integral arising in quantum field theory  

SciTech Connect

Recently, an interesting dilogarithmic integral arising in quantum field theory has been closed-form evaluated in terms of the Clausen function Cl{sub 2}({theta}) by Coffey [J. Math. Phys. 49, 093508 (2008)]. It represents the volume of an ideal tetrahedron in hyperbolic space and is involved in two intriguing equivalent conjectures of Borwein and Broadhurst. It is shown here by simple and direct arguments that this integral can be expressed by the triplet of the Clausen function values which are involved in one of the two above-mentioned conjectures.

Cvijovic, Djurdje [Atomic Physics Laboratory, Vinca Institute of Nuclear Sciences, P.O. Box 522, 11001 Belgrade (Serbia)

2009-02-15

423

Target cells for avian myeloblastosis virus in embryonic yolk sac and relationship of cell differentiation to cell transformation.  

PubMed Central

The yolk sac of the 12-day chicken embryo retains the blast stage progenitors to cells of the myeloid lineages with a very low level of contamination by more mature myeloid cells which have begun to express the characteristic myeloid cell markers. Both in vivo and in vitro experiments have supported the hypothesis that target cells for the BAI-A strain of avian myeloblastosis virus are contained within the myeloid lineages. An assay system for avian myeloblastosis virus was developed which utilizes this yolk sac cell system and which appears to be more sensitive than previous published assays. In addition, the kinetics of a liquid culture transformation system is presented in which at least 4% of the yolk sac cell population was transformed in a relatively synchronous fashion at 2 days after infection. The morphological transformation preceded an increased rate of cell proliferation. Cell separation procedures provided a 10- to 20-fold enrichment of target cells and demonstrated that the target cell population copurifies with macrophage colony-forming cells which are the committed progenitors to the macrophage lineage. In combination with earlier work, this work demonstrated that cells committed to the macrophage lineage at all stages of differentiation may serve as target cells for infection by avian myeloblastosis virus.

Boettiger, D; Durban, E

1984-01-01

424

Structure and glycosylation of the term yolk sac placenta and uterine attachment site in the viviparous shark Mustelus canis.  

PubMed

The viviparous shark Mustelus canis nurtures its young within the uterus by means of a modified yolk sac which functions as a placenta. Two term specimens have been examined with a panel of 21 biotinylated lectins to assess whether glycans form a prominent interface between fetal and maternal tissues as in their therian counterparts. The yolk sac placenta was lined by a thin egg envelope which apposed though did not make contact with the uterine epithelium, and expressed fucosyl, N-acetyl glucosamine/lactosamine residues and some complex N-glycan, while the attached, thin ectoderm cells stained selectively with lectins from Anguilla anguilla and Arachis hypogaea indicating fucosyl and beta-galactosyl residues; other lectins bound to a variable degree. Large yolk sac endoderm cells were heavily glycosylated and expressed a wide range of glycans. The apposing uterine epithelium had two epithelial layers with distinctive patterns of glycosylation, the apical layer stained strongly with Anguilla anguilla lectin and the basal cells with lectins from Wisteria floribunda and Helix pomatia, the latter indicating plentiful N-acetyl galactosamine though both layers stained variably with other lectins also. A population of sparse, large, globular cells expressed alpha2,3-linked sialic acid and N-acetyl glucosamine oligomers. Fetal and maternal vessels were heavily glycosylated as in their therian counterparts. These data indicate a prominent role for glycans at the fetomaternal interface of these chondrichthyan fishes. PMID:15451197

Jones, C J P; Hamlett, W C

2004-11-01

425

SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice.  

PubMed

Mutations of SLC26A4 are a common cause of human hearing loss associated with enlargement of the vestibular aqueduct. SLC26A4 encodes pendrin, an anion exchanger expressed in a variety of epithelial cells in the cochlea, the vestibular labyrinth and the endolymphatic sac. Slc26a4 (?/?) mice are devoid of pendrin and develop a severe enlargement of the membranous labyrinth, fail to acquire hearing and balance, and thereby provide a model for the human phenotype. Here, we generated a transgenic mouse line that expresses human SLC26A4 controlled by the promoter of ATP6V1B1. Crossing this transgene into the Slc26a4 (?/?) line restored protein expression of pendrin in the endolymphatic sac without inducing detectable expression in the cochlea or the vestibular sensory organs. The transgene prevented abnormal enlargement of the membranous labyrinth, restored a normal endocochlear potential, normal pH gradients between endolymph and perilymph in the cochlea, normal otoconia formation in the vestibular labyrinth and normal sensory functions of hearing and balance. Our study demonstrates that restoration of pendrin to the endolymphatic sac is sufficient to restore normal inner ear function. This finding in conjunction with our previous report that pendrin expression is required for embryonic development but not for the maintenance of hearing opens the prospect that a spatially and temporally limited therapy will restore normal hearing in human patients carrying a variety of mutations of SLC26A4. PMID:23874234

Li, Xiangming; Sanneman, Joel D; Harbidge, Donald G; Zhou, Fei; Ito, Taku; Nelson, Raoul; Picard, Nicolas; Chambrey, Régine; Eladari, Dominique; Miesner, Tracy; Griffith, Andrew J; Marcus, Daniel C; Wangemann, Philine

2013-07-11

426

Radiotherapy for a second primary lung cancer arising post-pneumonectomy: planning considerations and clinical outcomes  

PubMed Central

Background: Second primary non-small cell lung cancer (SPLC) is a significant cause of death amongst lung cancer survivors. As subsequent surgery is seldom feasible post-pneumonectomy, we studied the long-term clinical outcomes achieved with curative radiotherapy using modern delivery techniques. Methods Retrospective review of an institutional database between 2003-2011 identified 27 patients who had received curative radiotherapy for SPLC arising post-pneumonectomy. Treatments included; stereotactic ablative radiotherapy (SABR, n=20, dose 54-60 Gy in 3-8 fractions), hypofractionated radiotherapy (HFR, n=6, dose 39-60 Gy in 12-23 fractions) and conventional radiotherapy (RT, n=1, 60 Gy in 30 fractions). Clinical follow-up with a CT scan at 3, 6 and 12 months, then yearly was performed. Toxicities were scored using the common toxicity criteria for adverse events (version 4.0). Results The median overall survival was 39 months (95% CI, 33-44 months). After a median follow-up of 52 months (95% CI, 37-67 months), any recurrence was observed in four (15%) patients. Actuarial 3-year rates of local, regional and distant recurrences were 8% (95% CI, 0-21 months), 10% (95% CI, 0-23%) and 9% (95% CI, 0-20%), respectively. Patients receiving HFR or RT all had centrally located tumors. Of the patients treated with HFR delivered 12 fractions, 75% (3/4) developed grade 3 or higher radiation pneumonitis (RP), including one probable grade 5 toxicity. Of those receiving RT or HFR in 13 or more fractions no (0/3) grade 3 or worse RP was observed, despite such treatment being used for larger tumors and resulting in worse lung dose-volume histogram metrics. All the patients who developed RP had radiotherapy plans, which prioritized the sparing of central structures over lung sparing. No non-RP grade 3 or higher toxicities were observed. Conclusions Curative radiotherapy is an effective treatment for SPLC arising post-pneumonectomy. For larger central tumors, our data suggests that plans should prioritize reducing lung doses above the sparing of central structures.

Haasbeek, Cornelis J. A.; Lagerwaard, Frank J.; Verbakel, Wilko F.; de Haan, Patricia F.; Slotman, Ben J.; Senan, Suresh

2013-01-01

427

Effect of oestradiol treatment on mast cell populations and microflora in the vaginal cul-de-sac of seasonally anoestrous brushtail possums (Trichosurus vulpecula)  

Microsoft Academic Search

Mast cell populations in the vaginal cul-de-sac of female brushtail possums do not appear to be related to microbial invasion but changes in their density occur at oestrus, indicating a hormonal influence. The present study examined the effect of treatment with oestradiol on microflora and on mast cell numbers and their spatial location in cul-de-sac tissue of seasonally anoestrous brushtail

P. M. Mahoney; P. R. Hurst; B. J. McLeod; M. A. McConnell; E. G. Thompson

2003-01-01

428

A method for removal of toxic chromium using dialysis-sac cultures of a chromate-reducing strain of Enterobacter cloacae.  

PubMed

A method for removal of toxic hexavalent chromium (chromate: CrO2-4) was developed by use of dialysis-sac cultures of a chromate-reducing strain of Enterobacter cloacae (HO1). E. cloacae strain HO1 cells were put in dialysis (semipermeable membrane) sacs, and the sacs were submerged in water containing toxic CrO2-4. The dialysis sacs allowed CrO2-4 to diffuse into the culture, and CrO2-4 was reduced anaerobically in the dialysis sacs by the E. cloacae cells. Because reduced chromium readily formed insoluble chromium hydroxides in the dialysis sacs, the greater part of reduced chromium was unable to diffuse out through the semipermeable membrane. Thus the dialysis culture of E. cloacae strain HO1 could successfully remove toxic chromium from the surrounding water. If the initial concentration of CrO2-4 was less than 4 mM (208 ppm as chromium), about 90% of the total chromium could be removed from water by the described method. PMID:1366562

Komori, K; Rivas, A; Toda, K; Ohtake, H

1990-04-01

429

Sus1, Cdc31, and the Sac3 CID Region Form a Conserved Interaction Platform that Promotes Nuclear Pore Association and mRNA Export  

PubMed Central

Summary The yeast Sac3:Cdc31:Sus1:Thp1 (TREX-2) complex facilitates the repositioning and association of actively transcribing genes with nuclear pores (NPCs)—“gene gating”—that is central to integrating transcription, processing, and mRNA nuclear export. We present here the crystal structure of Sus1 and Cdc31 bound to a central region of Sac3 (the CID domain) that is crucial for its function. Sac3CID forms a long, gently undulating ? helix around which one Cdc31 and two Sus1 chains are wrapped. Sus1 has an articulated helical hairpin fold that facilitates its wrapping around Sac3. In vivo studies using engineered mutations that selectively disrupted binding of individual chains to Sac3 indicated that Sus1 and Cdc31 function synergistically to promote NPC association of TREX-2 and mRNA nuclear export. These data indicate Sac3CID provides a scaffold within TREX-2 to integrate interactions between protein complexes to facilitate the coupling of transcription and mRNA export during gene expression.

Jani, Divyang; Lutz, Sheila; Marshall, Neil J.; Fischer, Tamas; Kohler, Alwin; Ellisdon, Andrew M.; Hurt, Ed; Stewart, Murray

2009-01-01

430

Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.  

PubMed

BubR1 acetylation is essential in mitosis. Mice heterozygous for the acetylation-deficient BubR1 allele (K243R/+) spontaneously developed tumors with massive chromosome missegregations. K243R/+ mouse embryonic fibroblasts (MEFs) exhibited a weakened spindle assembly checkpoint (SAC) with shortened mitotic timing. The generation of the SAC signal was intact, as Mad2 localization to the unattached kinetochore (KT) was unaltered; however, because of the premature degradation of K243R-BubR1, the mitotic checkpoint complex disassociated prematurely in the nocodazole-treated condition, suggesting that maintenance of the SAC is compromised. BubR1 acetylation was also required to counteract excessive Aurora B activity at the KT for stable chromosome-spindle attachments. The association of acetylation-deficient BubR1 with PP2A-B56? phosphatase was reduced, and the phosphorylated Ndc80 at the KT was elevated in K243R/+ MEFs. In relation, there was a marked increase of micronuclei and p53 mutation was frequently detected in primary tumors of K243R/+ mice. Collectively, the combined effects of failure in chromosome-spindle attachment and weakened SAC cause genetic instability and cancer in K243R/+ mice. PMID:23878276

Park, Inai; Lee, Hae-ock; Choi, Eunhee; Lee, Yoo-Kyung; Kwon, Mi-Sun; Min, Jaewon; Park, Pil-Gu; Lee, Seonju; Kong, Young-Yun; Gong, Gyungyub; Lee, Hyunsook

2013-07-22

431

Brain tumors in adults with medically intractable epilepsy.  

PubMed

Much of the literature on tumors arising in the setting of chronic epilepsy focuses on children. This study reviewed 1 institution's 141-patient experience with tumors in adults arising in this clinical setting. The majority of tumors (71.6%) arose in the temporal lobe. The most common tumor types encountered included ganglioglioma (n = 38), low-grade fibrillary astrocytoma (n = 24), and low-grade oligodendroglioma (n = 22). Coexistent focal cortical dysplasia (type IA) was identified in 15 cases (10.6%). The largest group of tumors in adults were World Health Organization (WHO) grade II neoplasms compared with WHO grade I tumors in children. Gangliogliomas are the most commonly encountered neoplasms. Coexistent focal cortical dysplasia may be observed in a significant minority of tumors, suggesting a possible developmental origin for some of these neoplasms. PMID:21917677

Prayson, Richard A

2011-10-01

432

Mesenchymal progenitor cells from canine fetal tissues: yolk sac, liver, and bone marrow.  

PubMed

During fetal development, mesenchymal progenitor (MP) cells are co-localized in major hematopoietic territories, such as yolk sac (YS), bone marrow (BM), liver (LV), and others. Studies using mouse and human MP cells isolated from fetus have shown that these cells are very similar but not identical to adult mesenchymal stem cells (MSC). Their differentiation potential is usually restricted to production of highly committed osteogenic and chondrogenic precursors. Such properties of fetal MP cells can be very useful for tissue regeneration, when a great number of committed precursors are required. The objectives of this study were to isolate and characterize MP cells from canine YS, BM, and LV in early and late stages of fetal development. Gestational stage was identified, and cell culture conditions were evaluated for efficient isolation of canine MP cells. All canine fetal MP cells expressed vimentin, nestin, and CD44 proteins. Cytokeratin 18 expression was observed in BM- and LV-MP cells, and vascular endothelial (VE)-cadherin expression was observed only in YS-MP cells. A small number of MP cells (5%) from LV and YS expressed Oct3/4 protein. The differentiation potential of canine fetal MP cells varied significantly: YS- and BM-MP cells differentiated into bone and cartilage, whereas LV-MP cells differentiation was limited to osteogenic fate. None of the canine fetal MP cells were able to differentiate into adipose cells. Our data suggest that canine fetal MP cells are an appropriate in vitro model to study MP biology from hematopoietic territories and they are a source of committed osteogenic and chondrogenic precursors for regenerative medicine. PMID:21529262

Wenceslau, Cristiane Valverde; Miglino, Maria Angélica; Martins, Daniele Santos; Ambrósio, Carlos Eduardo; Lizier, Nelson Foresto; Pignatari, Graciela Conceição; Kerkis, Irina

2011-09-01

433

Intraoral sonographic evaluation of parapharyngeal space tumors.  

PubMed

We performed transcutaneous (external) sonography and then intraoral sonography to evaluate 3 parapharyngeal space tumors (1 vagal paraganglioma, 1 pleomorphic adenoma, and 1 carcinoma arising in a pleomorphic adenoma). All 3 patients had medial displacement of a tonsil. In all cases, we could measure the size and see the borders of the tumors and their relation to other structures on intraoral sonography. Intraoral sonography is useful for differentiating between unilaterally enlarged and medially displaced tonsils. PMID:11486327

Rebol, J; Takac, I; Bumber, Z

2001-06-01

434

[Tumoral exophthalmitis].  

PubMed

Proptosis due to intraorbital tumors is frequent and secondary to several etiologies. Generally, young people (0-20 years of age) will be affected mainly by benign diseases, such as angiomas or cysts (often dermoid cysts). Yet the ophthalmologist must never forget the possibility of rhabdomyosarcoma occurrence in a child. Adults (20-60 years of age) will for the most part develop benign tumors (cavernous hemangiomas, meningiomas) and inflammatory diseases. Last, malignant tumors, such as lymphomas and metastasized tumors, will mainly be observed in elderly people over 60 years of age. PMID:19853966

Ruban, J M; Baggio, E

2009-10-23

435

Low-grade central osteosarcoma arising from bone infarct.  

PubMed

Bone infarct-associated sarcoma is a rare sarcoma, accounting for less than 1% of all bone sarcomas. Its histology usually reflects a high-grade sarcoma, such as malignant fibrous histiocytoma of bone or conventional osteosarcoma. Low-grade sarcoma arising from bone infarct has not been described well in the literature. Here, we present a 17-year follow-up of a female patient with bone infarct in her right humerus, from which a low-grade central osteosarcoma developed during follow-up. A histologic diagnosis of low-grade central osteosarcoma was confirmed by immunohistochemical expression of MDM2 and CDK4. She underwent a wide resection surgery. As of 4 years after surgery, she has remained free of any evidence of recurrence or metastasis. Here, we present clinical and pathologic findings of our case in detail and discuss the differential diagnoses of this extremely rare condition. PMID:23375641

Endo, Makoto; Yoshida, Tatsuya; Yamamoto, Hidetaka; Ishii, Takeaki; Setsu, Nokitaka; Kohashi, Kenichi; Matsunobu, Tomoya; Iwamoto, Yukihide; Oda, Yoshinao

2013-01-31

436

Criminal prosecution arising from medical mishaps: a Japanese perspective.  

PubMed

In Japan, the number of physicians being investigated on suspicion of medical malpractice has increased. Specifically, the criminal prosecutions arising from professional negligence resulting in bodily injury or death have also increased. Article 21 of the Japanese Physician's Act compels a doctor to notify the district police when he diagnoses a death to be 'unnatural'. Originally this provision was to increase public safety through crime detection, but one recent criminal case broadened the application of this article to include the death from a mishap during medical treatment. This criminal case made a tremendous impact on physicians, as the convictions and sentences forced physicians to notify the police even when it is not certain the patient died of the malady or of the medical misconduct itself. Besides, we wonder if such obligation of doctors to notify such 'unnatural' death from medical mishap may be against a person's privilege against self-incrimination which is assured by Japanese Constitutional Law (article 38). PMID:16440862

Tsukamoto, Yasushi

2005-12-01

437

Transversely isotropic poroelasticity arising from thin isotropic layers  

SciTech Connect

Percolation phenomena play central roles in the field of poroelasticity, where two distinct sets of percolating continua intertwine. A connected solid frame forms the basis of the elastic behavior of a poroelastic medium in the presence of confining forces, while connected pores permit a percolating fluid (if present) to influence the mechanical response of the system from within. The present paper discusses isotropic and anisotropic poroelastic media and establishes general formulas for the behavior of transversely isotropic poroelasticity arising from laminations of isotropic components. The Backus averaging method is shown to provide elementary means of constructing general formulas. The results for confined fluids are then compared with the more general Gassmann formulas that must be satisfied by any anisotropic poroelastic medium and found to be in complete agreement.

Berryman, J.G.

1996-11-01

438

Neural representations of events arise from temporal community structure  

PubMed Central

Our experience of the world seems to divide naturally into discrete, temporally extended events, yet the mechanisms underlying the learning and identification of events are poorly understood. Research on event perception has focused on transient elevations in predictive uncertainty or surprise as the primary signal driving event segmentation. We present human behavioral and functional magnetic resonance imaging (fMRI) evidence in favor of a different account, in which event representations coalesce around clusters or ‘communities’ of mutually predicting stimuli. Through parsing behavior, fMRI adaptation and multivoxel pattern analysis, we demonstrate the emergence of event representations in a domain containing such community structure, but in which transition probabilities (the basis of uncertainty and surprise) are uniform. We present a computational account of how the relevant representations might arise, proposing a direct connection between event learning and the learning of semantic categories.

Schapiro, Anna C.; Rogers, Timothy T.; Cordova, Natalia I.; Turk-Browne, Nicholas B.; Botvinick, Matthew M.

2013-01-01

439

Estimation of measurement uncertainty arising from manual sampling of fuels.  

PubMed

Sampling is an important part of any measurement process and is therefore recognized as an important contributor to the measurement uncertainty. A reliable estimation of the uncertainty arising from sampling of fuels leads to a better control of risks associated with decisions concerning whether product specifications are met or not. The present work describes and compares the results of three empirical statistical methodologies (classical ANOVA, robust ANOVA and range statistics) using data from a balanced experimental design, which includes duplicate samples analyzed in duplicate from 104 sampling targets (petroleum retail stations). These methodologies are used for the estimation of the uncertainty arising from the manual sampling of fuel (automotive diesel) and the subsequent sulfur mass content determination. The results of the three methodologies statistically differ, with the expanded uncertainty of sampling being in the range of 0.34-0.40 mg kg(-1), while the relative expanded uncertainty lying in the range of 4.8-5.1%, depending on the methodology used. The estimation of robust ANOVA (sampling expanded uncertainty of 0.34 mg kg(-1) or 4.8% in relative terms) is considered more reliable, because of the presence of outliers within the 104 datasets used for the calculations. Robust ANOVA, in contrast to classical ANOVA and range statistics, accommodates outlying values, lessening their effects on the produced estimates. The results of this work also show that, in the case of manual sampling of fuels, the main contributor to the whole measurement uncertainty is the analytical measurement uncertainty, with the sampling uncertainty accounting only for the 29% of the total measurement uncertainty. PMID:23598031

Theodorou, Dimitrios; Liapis, Nikolaos; Zannikos, Fanourios

2012-10-29

440

Magnetic resonance imaging and thallium-201 scintigraphy for the diagnosis of localized pigmented villonodular synovitis arising from the elbow: A case report and review of the literature  

PubMed Central

Pigmented villonodular synovitis (PVNS) arising from the elbow joint is extremely rare; only 24 cases have been reported. It is extremely difficult to differentiate PVNS from other soft tissue tumors on the basis of imaging findings alone. Therefore, a biopsy is required for definitive diagnosis. A 20-year-old female reported a mass on her right elbow. Physical examination revealed a tumor measuring 3.0x3.0 cm. Magnetic resonance imaging (MRI) revealed that the signal intensity of the tumor was isointense to muscle on T1-weighted images; however, it was hyper- or isointense to muscle on T2-weighted images. In images obtained by gadolinium-enhanced MRI, the margin of the tumor was well-contrasted. Thallium (Tl)-201 scintigrams revealed an abnormal accumulation in the area of the mass in the early and delayed phases. On the basis of clinical findings, imaging characteristics and incision biopsy results, localized PVNS was diagnosed and marginal excision was performed. We thus identified an extremely rare case of PVNS arising from the elbow joint. When interpreting Tl-201 images for the assessment of bone and soft tissue lesions, it is important to recognize PVNS as a condition that simulates malignant tumors. Furthermore, PVNS should be considered in the differential diagnosis when increased Tl-201 activity is closely related to the joint. MRI aids in the differentiation by demonstrating features of hemosiderin degradation products. These findings are likely to be extremely helpful in the differential diagnosis of bone and soft tissue tumors.

KOTO, KAZUTAKA; MURATA, HIROAKI; SAKABE, TOMOYA; MATSUI, TAKAAKI; HORIE, NAOYUKI; SAWAI, YASUSHI; TSUJI, YOSHIRO; KUBO, TOSHIKAZU

2013-01-01

441

Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma  

ClinicalTrials.gov

Childhood Burkitt Lymphoma; Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Childhood Choroid Plexus Tumor; Childhood Craniopharyngioma; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Medulloepithelioma; Childhood Meningioma; Childhood Mixed Glioma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Childhood Oligodendroglioma; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Childhood Subependymal Giant Cell Astrocytoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Childhood Visual Pathway and Hypothalamic Glioma; Recurrent Childhood Visual Pathway Glioma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Unspecified Childhood Solid Tumor, Protocol Specific

2013-07-01

442

Giant lipoma arising from deep lobe of the parotid gland  

Microsoft Academic Search

Background  Lipomas are common benign soft tissue neoplasms but they are found very rarely in the deep lobe of parotid gland. Surgical\\u000a intervention in these tumors is challenging because of the proximity of the facial nerve, and thus knowledge of the anatomy\\u000a and meticulous surgical technique are essential.\\u000a \\u000a \\u000a \\u000a \\u000a Case presentation  A 71-year-old female presented with a large asymptomatic mass, which had occupied

Che-Wei Wu; Hung-Pin Chi; Feng-Yu Chiang; Ying-Che Hsu; Leong-Perng Chan; Wen-Rei Kuo

2006-01-01

443

Cellular Origin of Breast Tumors With Invasive Potential.  

National Technical Information Service (NTIS)

A major problem in breast cancer treatment and the leading cause of mortality is invasion and metastasis of primary breast tumors. The cell type from which the tumor arises may dictate its potential for aggressive behavior. The mammary gland consists of d...

G. L. Radice

2004-01-01

444

Differential diagnosis of gastrointestinal leiomyoma versus gastrointestinal stromal tumor  

Microsoft Academic Search

Introduction: Strategies for the diagnosis of tumors arising in the intestinal muscular wall are rap- idly evolving. Immunoreactivity for CD117 (KIT) usually supports the diagnosis of gastrointestinal stromal tumor (GIST), but a small subset of GISTs lacks KIT expression. In these cases the differential diagnosis of KIT-negative GIST versus one of their morphological mimics is diffi- cult and bears critical

Jens Kuhlgatz; Bjoern Sander; Mariola Monika Golas; Bastian Gunawan; Thorsten Schulze; Hans-Jürgen Schulten; Eva Wardelmann; László Füzesi

2006-01-01

445