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1

"Somatic-type" Malignancies Arising From Testicular Germ Cell Tumors: A Clinicopathologic Study of 124 Cases With Emphasis on Glandular Tumors Supporting Frequent Yolk Sac Tumor Origin.  

PubMed

Somatic-type malignancies (SMs) in patients with testicular germ cell tumors (GCT) are rare and mostly attributed to "transformation" of teratoma, although yolk sac tumor (YST) origin has also been proposed. We studied 124 cases of "SM" of testicular GCT origin from 106 patients to evaluate their morphology, immunohistochemical features (especially the utility of SALL4), and relationship to YST. Primitive neuroectodermal and nephroblastomatous tumors were excluded because of prior studies. Patients ranged in age from 15 to 68 years (mean, 33 y). The tumors ranged from 0.7 to 30 cm (mean, 7.6 cm) and involved the retroperitoneum (64%), abdomen/pelvis (10%), lung (10%), mediastinum (6%), supraclavicular region/neck (4%), testis (4%), and thigh (1%). Most initial diagnoses were sarcomas (n=68) or carcinomas (n=51). On review and immunohistochemical analysis, 7 of 45 adenocarcinomas were reclassified as glandular YSTs (GYST) on the basis of glypican-3 (GPC3) and/or ?-fetoprotein positivity and scant/absent reactivity for EMA and CK7. These occasionally (29%) had subnuclear and sometimes supranuclear vacuoles (endometrioid-like), whereas adenocarcinomas were more frequently mucinous (17%) or enteric-type (11%) than endometrioid-like (9%). Both expressed CDX2 frequently (83% and 63%, respectively). MUC protein 2, 4, 5, and 6 expression was more common in adenocarcinomas (7% to 36%) than in GYSTs (0% to 20%) but was infrequent. Both were often positive for SALL4, BerEP4, and MOC31; all were negative for TTF-1. On follow-up (GYST: range, 23 to 169 mo; mean, 81mo; adenocarcinoma: range, 1 to 170 mo; mean, 55 mo), 50% and 33% of patients with GYST and adenocarcinoma, respectively, died of disease. We reclassified 26 of 76 sarcomatoid tumors as sarcomatoid YSTs (SYST) on the basis of positive reactivity for both AE1/3 and GPC3. These tumors often had spindled and epithelioid cells in a fibromyxoid stroma. SYSTs were often (60%) SALL4 positive, whereas sarcomas were all negative. On follow-up (SYST: range, 1 to 259 mo; mean, 62 mo; sarcoma: range, 1 to 327 mo; mean, 70 mo), 50% and 29% of patients with SYST and sarcoma, respectively, died of disease, with most mortality occurring in those with high-grade tumors. We conclude that, on the basis of a panel of immunoreactivities, a significant number of "SMs" in testicular GCT patients are more accurately classified as either GYSTs or SYSTs. Ambiguous glandular tumors should be evaluated for GPC3, ?-fetoprotein, CK7, and EMA reactivity and sarcomatoid ones for GPC3, AE1/3, and SALL4 reactivity. PMID:24921638

Magers, Martin J; Kao, Chia-Sui; Cole, Cristina D; Rice, Kevin R; Foster, Richard S; Einhorn, Lawrence H; Ulbright, Thomas M

2014-10-01

2

Gastric adenocarcinoma with yolk sac tumor differentiation and liver metastasis of yolk sac tumor component.  

PubMed

Gastric adenocarcinoma with yolk sac tumor (YST) differentiation has rarely been reported. We report a case of primary gastric adenocarcinoma with yolk sac tumor differentiation and liver metastases of the YST component in a 50-years-old patient. This was suspected due to high serum level of alpha fetoprotein in the presence of a gastric fundal tumor. Gastric carcinoma with yolk sac tumor component is a rare entity with a poor prognostic outcome. PMID:24294529

Bihari, Chhagan; Rastogi, Archana; Chandan, K N; Yadav, Vikas; Panda, Dipanjan

2013-01-01

3

Gastric Adenocarcinoma with Yolk Sac Tumor Differentiation and Liver Metastasis of Yolk Sac Tumor Component  

PubMed Central

Gastric adenocarcinoma with yolk sac tumor (YST) differentiation has rarely been reported. We report a case of primary gastric adenocarcinoma with yolk sac tumor differentiation and liver metastases of the YST component in a 50-years-old patient. This was suspected due to high serum level of alpha fetoprotein in the presence of a gastric fundal tumor. Gastric carcinoma with yolk sac tumor component is a rare entity with a poor prognostic outcome. PMID:24294529

Bihari, Chhagan; Rastogi, Archana; Chandan, K. N.; Yadav, Vikas; Panda, Dipanjan

2013-01-01

4

Primary yolk sac tumor of the cerebellar vermis: a case report.  

PubMed

Extragonadal germ cell tumors are rare and comprise 2-5% of all germ cell tumors. Seminoma/dysgerminoma, teratoma, yolk sac tumor (YST) and mixed germ cell tumors are few of the extragonadal germ cell tumors arising within the brain. Of these, primary pure YSTs arising in the brain are extremely rare and arise in the pineal (62%) and suprasellar (31%) regions. Primary YST occurring in the cerebellum is exceedingly rare, associated with a very poor prognosis and has been reported in less than 10 cases in literature. We herein report a case of primary pure yolk sac tumor in the cerebellar vermis in a 2-year-old child. PMID:24943765

Shenoy, Asha S; Desai, Heena M; Tyagi, Devendra K; Savant, Hemant V; Kavishwar, Vikas S; Balasubramaniam, Meenakshi

2014-01-01

5

Sacrococcygeal Yolk Sac Tumor: An Uncommon Site  

PubMed Central

A 30-month-old male infant presented with sacrococcygeal and pre-sacral mass. Ultrasound (US) abdomen revealed a huge pre-sacral mass with irregular margins extending into the pelvis, pushing the rectum antero-laterally. CT scan and MRI confirmed the US findings. Serum alpha fetoprotein level was abnormally elevated. Histopathological examination of surgical-specimen suggested sacrococcygeal yolk sac tumor (YST). PMID:23061033

Koubaa-Mahjoub, Wafa; Jouini, Raja; Bel Haj Salah, Meriem; Kaabar, Nejib; Chadli-Debbiche, Achraf

2012-01-01

6

Primary yolk sac tumor of seminal vesicle: a case report and literature review  

PubMed Central

Background Yolk sac tumor (endodermal sinus tumor) is a rare malignant germ cell tumor arising in the testis or ovary. Extragonadal yolk sac tumor is even rarer and has only been described in case reports. Due to the rarity of the tumors, the appropriately optimal treatment remains unclear. We report a case of yolk sac tumor in the seminal vesicle. Case A 38-year-old Asian male presented with gross hematuria and hemospermia. Transrectal ultrasound scan showed a solid mass in the left seminal vesicle and the scrotal sonography showed no abnormalities. Bilateral seminal vesicles were resected, and histopathological examination showed a typical pattern of yolk sac tumor (YST). The patient responded poorly to comprehensive treatment of radiotherapy, chemotherapy and surgeries, developed systemic multiple metastases, and died of cachexia one and half years after diagnosis. PMID:22978485

2012-01-01

7

Extragonadal yolk sac tumor in pelvic localization. A case report and literature review  

Microsoft Academic Search

Background. Yolk sac tumor (YST) is a rare neoplasm that usually arises in the testis or ovary. We report a case of extragonadal yolk sac tumor located in the pelvic area.Case. A 33-year-old woman was admitted with a history of abdominal pain and distension. Transvaginal ultrasonography showed a 63 × 63-mm hyperechoic mass and pelvic computerized scanning reported a pelvic

Murat Dede; Recai Pabuccu; Gokhan Yagci; Mufit Cemal Yenen; Umit Goktolga; Omer Gunhan

2004-01-01

8

Aggressive papillary tumor of the middle ear: a true entity or an endolymphatic sac neoplasm?  

PubMed

Aggressive papillary tumors of the middle ear are rare, and their true origin is not clear. We describe the clinical, radiologic, genetic, and histopathologic features of a papillary epithelial tumor filling the middle ear of a 68-year-old woman. Imaging revealed no evidence of petrous temporal bone apex involvement, nor did genetic studies demonstrate the von Hippel-Lindau mutation. A literature search revealed 24 previously reported cases of such a papillary epithelial tumor of the middle ear. All except 2 cases demonstrated apical petrous temporal bone invasion on imaging, and it has been suggested that they arose from a primary endolymphatic sac tumor, which has a similar papillary epithelial histology. Substantial numbers of cases of papillary epithelial tumors involving the middle ear are reported to be associated with von Hippel-Lindau disease, as are known cases of endolymphatic sac tumor. This is the third reported case of papillary epithelial tumor of the middle ear that does not show apical petrous temporal bone invasion on imaging, suggesting that such neoplasms do not always arise from a primary in the endolymphatic sac. PMID:18633929

Tysome, James R; Harcourt, Jonny; Patel, Manish C; Sandison, Ann; Michaels, Leslie

2008-07-01

9

Parapharyngeal and skull base yolk sac tumor: A case report with lessons in diagnosis and management.  

PubMed

Yolk sac tumors are rare in the head and neck. A previously healthy 2-year-old female presented with a large parapharyngeal mass. Pathology was pathognomonic for yolk sac tumor, with glandular differentiation and focal mucin production, which has not been reported in a yolk sac tumor. She was treated aggressively with chemotherapy followed by endoscopic exploration with planned resection, but no viable tumor was encountered. Yolk sac tumors can be difficult to diagnose in the head and neck, but complete clinical response can be achieved. New endoscopic approaches to skull base tumors are applicable to the pediatric population with some technical modifications. PMID:25200853

Hauser, Leah J; Chiang, Tendy; Ramakrishnan, Vijay R; Lovell, Mark A; Kelley, Peggy E

2014-11-01

10

Occurrence of metachronous pure germinomas long after treatment of a mixed germ cell tumor containing yolk sac tumor and germinoma.  

PubMed

The authors report a rare case involving the occurrence of metachronous pure germinomas long after treatment of a mixed germ cell tumor (GCT) categorized as having a poor prognosis. A neurohypophysial germinoma occurred 4 years and 6 months after the initial treatment of a mixed pineal GCT containing a yolk sac tumor and a germinoma. Furthermore, intramedullary germinomas occurred 21 years after the initial treatment of the mixed GCT and 15 years after the second treatment of the neurohypophysial germinoma. The neurohypophysial germinoma was not confirmed histopathologically, but the intramedullary germinoma was histopathologically diagnosed as a pure germinoma. Serum ?-fetoprotein levels at the second neurohypophysial and third intramedullary occurrences of the germinomas were less than 10 ng/ml. Therefore, no yolk sac components seemed to be contained in the tumors. The second neurohypophysial and third intramedullary germinomas might be recurrences of the germinoma component of the pineal mixed GCT, which consisted of a yolk sac tumor and a germinoma. However, it seems very unlikely that only the germinoma, categorized in the good prognosis group, would be the only one to recur. Hence, it seems plausible that both the second and the third occurrences of pure germinoma were de novo metachronous GCTs arising after the pineal mixed GCT was cured. The authors' case indicates the possibility of multicentric GCTs in the CNS. PMID:23082803

Jinguji, Shinya; Okamoto, Kouichirou; Yoshimura, Junichi; Yoneoka, Yuichiro; Ogura, Ryousuke; Saito, Akihiko; Fujii, Yukihiko

2013-01-01

11

Cardiac metastasis from yolk sac tumor: case report and review  

PubMed Central

Cardiac metastasis of germ cell tumors is extremely rare, particularly in females. We report a case of a 26-year-old previously healthy woman who presented with a 5-month history of abdominal pain, weight loss, fever, generalized lymphadenopathy, and acanthosis nigricans. Biopsy of cervical lymph nodes revealed a poorly differentiated neoplasm. Immunohistochemical staining was positive for alpha-fetoprotein suggesting the diagnosis of a germ cell tumor. During the investigation, the patient developed heart failure and a mass attached to the right ventricle was detected by the echocardiogram. In a few days, she developed multiple organ failure and died. Post-mortem examination revealed a malignant mixed germ cell tumor of the right ovary with extensive hematogenic and lymphatic dissemination, a polypoid mass attached to the right ventricle, emboli in the endocardial and epicardial vessels, and infiltration surrounding the coronary arteries. To the best of our knowledge this is the third report of grossly visible heart metastases from a yolk sac tumor in a female patient. A summary of all published cases of germ cell tumors with cardiac metastasis over the last 20 years is also presented. PMID:23631464

2013-01-01

12

Combined effect of vascular-leakage-blocker Sac-1004 and antiangiogenic drug sunitinib on tumor angiogenesis.  

PubMed

Tumor blood vessels are often leaky because of poor covering by mural cells and loose cell-to-cell contacts. Leaky vessels result in hemorrhage and limited vascular perfusion, which lead to hypoxic tumor microenvironment. Antiangiogenic agents have been shown to normalize the tumor blood vessels, albeit temporarily. Continued administration has been found to be associated with increased tumor hypoxia, a major driving force behind chemoresistance and metastasis. Sac-1004 was recently demonstrated to prevent vascular leakage, normalize tumor vessels and prevent metastasis in sustained manner. Here, we sought that combining antiangiogenic agent, sunitinib with Sac-1004 could have better inhibitory effect upon tumor growth. We found that B16F10 tumor growth was significantly reduced and tumor-bearing mice survival was increased upon combining sunitinib therapy with Sac-1004. In concordance with this observation, tumor vascular perfusion was substantially improved in tumors receiving combination therapy. In addition, tumor vascular leakage was reduced to higher extent in combination treatment group as compared to either therapy alone, an effect attributed to improved vascular junction. Interestingly, hypoxia in tumor environment was significantly reduced, when sunitinib was combined with Sac-1004. Taken together, our data demonstrates that combining antiangiogenic therapy with vascular-leakage inhibiting agent might be a beneficial strategy to combat cancer. PMID:25003323

Lee, Keunho; Agrawal, Vijayendra; Kim, Kyeojin; Kim, Jihye; Park, Hyojin; Lee, Sungwoon; Kim, Young-Myeong; Suh, Young-Ger; Kwon, Young-Guen

2014-08-01

13

Intracranial pure yolk sac tumor in the anterior third ventricle of an adult: A case report  

PubMed Central

A 45-year-old female patient presented with symptoms of polydipsia and polyuria, menopause, headache, gait disturbance and deteriorated mental state. Brain magnetic resonance imaging (MRI) showed an irregular mass in the anterior third ventricle. The tumor was excised using a transfrontal approach from the anterior section of the third ventricle. The histological diagnosis was of an intracranial pure yolk sac tumor. The patient underwent radiotherapy and suffered no tumor recurrence one year after the surgery. Overall, when heterogeneous enhancement and an irregular mass with surrounding invasion and ventricular dilation are observed in the anterior third ventricle of an adult, a yolk sac tumor should be considered, and MRI may aid the differential diagnosis. A combination of surgical resection and radiotherapy is recommended for the yolk sac tumor. PMID:25289043

ZHAO, SUHONG; SHAO, GUANGRUI; GUO, WEIHUA; CHEN, XIUBIN; LIU, QINGWEI

2014-01-01

14

MR Imaging Findings of Extraovarian Endocervical Mucinous Borderline Tumors Arising from Pelvic Endometriosis  

PubMed Central

We report MR imaging findings of a rare case of endocervical mucinous borderline tumor (MBT) involving the cul-de-sac and left fallopian tube arising from extensive pelvic endometriosis with pathologic correlation in a 35-year-old woman presented with vague pelvic pain. Endocervical MBT is a type of endometriosis-associated carcinoma. Imaging findings of endocervical MBT are unilocular or oligolocular cystic lesions with enhancing mural nodules, which are different from those of the more common intestinal type MBT. PMID:24265567

Yeo, Dong Myung; Byun, Jae Young; Lee, Ahwon; Kim, Mee-Ran

2013-01-01

15

Warthin tumor arising from the minor salivary gland.  

PubMed

Warthin tumor (WT) accounts for 4% to 13% of all salivary gland tumors. This benign tumor, which commonly arises in the parotid gland, is the second most common tumor of the salivary gland. WT is multicentric in 12% to 20% of patients and is bilateral in 5% to 14%. The mean age at diagnosis is 62 years (range, 12-92 years), and it rarely presents (<6%) before age 40 years. Extraparotid WT, arising from the submandibular gland or cervical lymph node for example, is very infrequent, with corresponding incidences of 0.4% to 6.9% and 8%, respectively. Moreover, WT arising from the minor salivary gland is extremely rare, with a reported incidence of merely 0.1% to 1.2%. We report here WT arising from the minor salivary gland in the buccal mucosa in a 66-year-old woman and review cases of WT of the minor salivary gland reported in the English literature. PMID:22976673

Iwai, Toshinori; Baba, Junichi; Murata, Shogo; Mitsudo, Kenji; Maegawa, Jiro; Nagahama, Kiyotaka; Tohnai, Iwai

2012-09-01

16

Adenocarcinoma arising in warthin tumor of the parotid gland.  

PubMed

Warthin tumor is a well-defined benign salivary gland neoplasm consisting of both epithelial and lymphoid components. The tumor is the second most common benign tumor next to pleomorphic adenoma. We present a case of adenocarcinoma, not otherwise classified, arising in unilateral Warthin tumor of the parotid gland in a 63-year-old male patient. Carcinomas arising in or from the epithelial component of a preexisting parotid Warthin tumor are rare and differential diagnosis of metastasis from an adenocarcinoma in Warthin tumor is important. The patient underwent a complete and thorough work-up, and no other primary malignant lesion was found. No other primary malignant lesion had manifested at the last one year follow-up period. PMID:23011833

Sayar, Hamide; Öztarakçi, Hüseyin; Sayar, Ça?da?; A?irba?, ?ule

2012-01-01

17

A Primary Pure Yolk Sac Tumor of the Lung Exhibiting CDX-2 Immunoreactivity and Increased Serum Levels of Alkaline Phosphatase Intestinal Isoenzyme  

Microsoft Academic Search

Malignant extragonadal germ cell tumors primary to the lung are quite uncommon lesions, but pure yolk sac tumor is even more exceptional. This is believed to be the first reported case of yolk sac tumor of the lung in which an intense and diffuse immunoreactivity for CDX2, a marker of intestinal differentiation reportedly expressed also in gonadal yolk sac tumor,

Giuseppe Pelosi; Francesco Petrella; Maria Teresa Sandri; Lorenzo Spaggiari; Domenico Galetta; Giuseppe Viale

2006-01-01

18

Gonadoblastoma and hepatoid and endometrioid-like yolk sac tumor: an update.  

PubMed

Dr Robert E. Scully greatly advanced our understanding of germ cell neoplasia to the extent that it is difficult to narrow the discussion of his contributions to this topic so that it can be covered in a brief article. This article accordingly focuses on some of the recent developments concerning 2 of his major contributions in this area-the gonadoblastoma (GB) and variant morphologies of yolk sac tumor. GB was defined by Dr Scully in 1953 and its features elaborated in detail by him in 1970. This neoplasm occurred in young patients who often displayed phenotypic sex ambiguities and frequently presented with primary amenorrhea. It was bilateral in 40%, and consisted of circumscribed nests of small sex cord cells and germinoma-like cells admixed with round deposits of eosinophilic, hyaline, often calcified material. These nests were set in a spindle cell gonadal stroma with Leydig-like or lutein-like cells. Because of his work we now understand that this precursor to invasive germ cell tumors occurs in patients with a specific form of disorder of sex development, namely gonadal dysgenesis, and only in those who have a particular portion of the Y chromosome, the GB locus/TSPY gene, within the gonadal tissue. An essential element to the development of GB appears to be a defect in the genetic pathway that leads to the development of Sertoli cells. Improperly formed Sertoli cells predispose to "delayed maturation" of the gonocytes of the gonad and predispose them to undergo malignant transformation. "Undifferentiated gonadal tissue" has been proposed as the precursor to the development of GB and consists of an unorganized mixture of apparently non-neoplastic germ cells, germ cells with delayed maturation, and neoplastic germ cells with sex cord cells and gonadal stroma. Two variant morphologies of yolk sac tumor were also recognized by Dr Scully. In the hepatoid variant features similar to hepatocellular carcinoma occurred, although primitive glandular foci and lack of liver involvement permitted its distinction in most cases. More recently this variant has been found to occasionally produce bile in canalicular-like structures and to stain strongly for both SALL4 and glypican 3, 2 recently described markers of yolk sac tumor. Recognition of hepatoid yolk sac tumor was followed by the description of a potential mimic, primary ovarian hepatoid carcinoma, which, however, occurred in a significantly older patient population and was occasionally associated with surface epithelial neoplasia. The endometrioid-like variant of yolk sac tumor simulated primary endometrioid adenocarcinoma. It can be suspected on routine stains because of primitive appearing nuclei, frequent subnuclear vacuoles, and in some cases association with more usual yolk sac tumor. Its recognition is now facilitated by a panel of immunohistochemical stains that are often expressed differentially in these 2 neoplasms--endometrioid-like yolk sac tumor: positive for SALL4, glypican 3, and ?-fetoprotein; endometrioid adenocarcinoma: positive for cytokeratin 7 and epithelial membrane antigen. Finally, Dr Scully contributed one of the first cases in the literature of yet another nuance in the complicated world of yolk sac neoplasia, namely the development of some tumors on the background of a surface epithelial neoplasm. This is analogous to the more common development of choriocarcinoma from carcinoma and, in the case of yolk sac tumor, diagnosis is aided clinically by the usual older age of the patient and nature of the associated neoplasia. PMID:24901396

Ulbright, Thomas M

2014-07-01

19

Glomus tumor of uncertain malignant potential arising in the bronchus  

PubMed Central

Glomus tumor is usually a small, benign tumor and typically occurs in the dermis or subcutis or soft tissue of the extremities and rarely in the visceral locations. Its occurrence in the main bronchus is extremely rare. The current case reported a 30-year-old woman with dyspnea on exertion and hemoptysis, she had a glomus tumor which has large size, deep location and exhibits an infiltrative margin as well as increased atypical mitotic figures. These characteristics suggest malignant behavior. However, there is little data regarding glomus tumors arising in the bronchus, the need for caution in diagnosing this case as a malignant glomus tumor must be highlighted. Therefore, the diagnosis of bronchial glomus tumor of uncertain malignant potential was favored. To the best of our knowledge, both the type and the location of this glomus tumor are extremely rare. Accumulation of more cases are needed to clarify their diagnosis and significance since there is little data regarding glomus tumors arising in the bronchus. PMID:23758949

2013-01-01

20

Evaluation of cloned cells, animal model, and ATRA sensitivity of human testicular yolk sac tumor  

PubMed Central

The testicular yolk sac tumor (TYST) is the most common neoplasm originated from germ cells differentiated abnormally, a major part of pediatric malignant testicular tumors. The present study aimed at developing and validating the in vitro and vivo models of TYST and evaluating the sensitivity of TYST to treatments, by cloning human TYST cells and investigating the histology, ultra-structure, growth kinetics and expression of specific proteins of cloned cells. We found biological characteristics of cloned TYST cells were similar to the yolk sac tumor and differentiated from the columnar to glandular-like or goblet cells-like cells. Chromosomes for tumor identification in each passage met nature of the primary tumor. TYST cells were more sensitive to all-trans-retinoic acid which had significantly inhibitory effects on cell proliferation. Cisplatin induced apoptosis of TYST cells through the activation of p53 expression and down-regulation of Bcl- expression. Thus, we believe that cloned TYST cells and the animal model developed here are useful to understand the molecular mechanism of TYST cells and develop potential therapies for human TYST. PMID:22410253

2012-01-01

21

Yolk sac tumor in postmenopausal patients: pure or associated with adenocarcinoma, a rare phenomenon.  

PubMed

Yolk sac tumors (YSTs) of the ovary usually present in young women and have been rarely reported in postmenopausal patients. Most of the cases in young patients are pure or associated with other germ cell components; however, in older patients there is an unusual association with Müllerian epithelial elements, for the most part malignant. We report two cases, both in older patients. One of the YSTs was associated with high-grade serous and endometrioid carcinoma, while the other case showed pure YST. The YST component showed positivity for SALL4, AFP and Glypican-3 and negative staining for PAX8 supporting a germ cell tumor differentiation; SALL4 and PAX8 markers have not been previously analyzed in this setting. Both tumors recurred within 7 months despite systemic chemotherapy. PMID:25083963

Roma, Andres A; Przybycin, Christopher G

2014-09-01

22

Fine-needle aspiration cytology of unusual germ cell tumors of the mediastinum: atypical seminoma and parietal yolk sac tumor.  

PubMed

A 30-yr-old man presented with a mediastinal germ cell tumor that combined the histologic pattern of seminoma with the immunohistochemical profile of embryonal carcinoma (beta-HCG+/PLAP-). In FNA smears, this atypical seminoma presented as fragile large cells with scanty cytoplasm, vesicular nuclei, irregular and indistinct nucleoli, scattered singly and in loosely cohesive fragments without the characteristic lymphocytic or tigroid background. The cytologic features were more suggestive of a poorly differentiated carcinoma than seminoma, potentially leading to misdiagnosis and mismanagement. The second case was a 51-yr-old female smoker who presented with mediastinal parietal yolk sac tumor with extension to the lung, a rare occurrence, and contrary to the clinical impression of lung cancer with hilar lymph node metastasis. This case illustrates the value of using the unique cytologic features of parietal yolk sac tumor, i.e., the abundant, viscous, stringy metachromatic extracellular hyaline material associated with the tumor cells in reaching the accurate diagnosis. PMID:12203871

Yang, Grace C H; Hwang, Sonya J; Yee, Herman T

2002-08-01

23

Cribriform neuroepithelial tumor arising in the lateral ventricle.  

PubMed

Cribriform neuroepithelial tumor (CRINET) is a recently recognized central nervous system neoplasm that arises in the ventricles of young children and is characterized by primitive, non-rhabdoid SMARCB1-deficient cells with prominent cribriform architecture. We report a 14-month-old male who presented with signs of increased intracranial pressure. Neuroimaging revealed a large solid and cystic mass in the lateral ventricle. Tumor cells were small, primitive appearing, and arranged in cribriform and trabecular patterns with interspersed solid cellular areas. Rhabdoid cells were absent. Immunohistochemical staining showed no SMARCB1 (INI11, BAF47, hSNF5) expression and strong epithelial membrane antigen (EMA) immunoreactivity along luminal surfaces. Electron microscopy showed epithelial characteristics, including abundant basal lamina. Genetic analysis of the tumor revealed deletion of 1 SMARCB1 allele, while the other contained an intronic point mutation predicted to disrupt splicing. This case further illustrates the distinct histopathologic and molecular genetic features of CRINET and identifies distinctive ultrastructural features. PMID:23495723

Arnold, Michael A; Stallings-Archer, Kandi; Marlin, Evan; Grondin, Ronald; Olshefski, Randal; Biegel, Jaclyn A; Pierson, Christopher R

2013-01-01

24

A unique case of a sarcoma arising in a testicular non-seminomatous mixed germ cell tumour with a predominant yolk sac component  

PubMed Central

We present a unique case of a sarcoma arising in a testicular non-seminomatous mixed germ cell tumour with a predominant yolk sac tumour (YST) component. This is the first case reported in which a sarcoma is linked to YST of the testis in a patient not having undergone prior chemotherapy. This finding confirms the ability of YST to contain sarcoma; it underlies its importance for urologists, oncologists and pathologists to be aware of this phenomenon and to modify treatment strategies appropriately. PMID:21989175

Lavallee, Luke T.; Roustan Delatour, Nicolas LD; Cagiannos, Ilias; Belanger, Eric C; Mai, Kien T.

2011-01-01

25

Giant solitary fibrous tumor arising from greater omentum  

PubMed Central

Extrathoracic solitary fibrous tumors (SFTs) have been described at almost every anatomic location of human body, but reports of SFT in the abdominal cavity are rare. We herein present a rare case of SFT originating from greater omentum. Computed tomography revealed a 15.8 cm × 21.0 cm solid mass located at superior aspect of stomach. Open laparotomy confirmed its mesenchymal origin. Microscopically, its tissue was composed of non-organized and spindle-shaped cells exhibiting atypical nuclei, which were divided up by branching vessel and collagen bundles. Immunohistochemical staining showed that this tumor was negative for CD117, CD99, CD68, cytokeratin, calretinin, desmin, epithelial membrane antigen, F8 and S-100, but positive for CD34, bcl-2, ?-smooth muscle actin and vimentin. The patient presented no evidence of recurrence during follow-up. SFT arising from abdominal cavity can be diagnosed by histological findings and immunohistochemical markers, especially for CD34 and bcl-2 positive cases. PMID:23197901

Zong, Liang; Chen, Ping; Wang, Guang-Yao; Zhu, Qun-Shan

2012-01-01

26

Bleomycin-induced pulmonary fibrosis after tumor lysis syndrome in a case of advanced yolk sac tumor treated with bleomycin, etoposide and cisplatin (BEP) chemotherapy.  

PubMed

Ovarian yolk sac tumor (YST) is a highly aggressive malignancy arising in young women. Chemotherapy has dramatically improved the prognosis, and bleomycin, etoposide, and cisplatin (BEP) combination chemotherapy appears to be the most effective combination regimen. A 23-year-old woman was admitted to our hospital with worsening abdominal distention and a lower abdominal mass. She was diagnosed with a stage IIIc pure YST of the right ovary, and right salpingo-oophorectomy was performed; there were numerous disseminated peritoneal tumors within the abdominal cavity. A few days postoperatively, massive ascites developed, and right hydronephrosis occurred. Chemotherapy with BEP was started, and after 24 h of administration, oliguria and tumor lysis syndrome (TLS) developed. Continuous hemodiafiltration was started, and hemodialysis was initiated following full-dose standard cisplatin and etoposide on days 2-5 of the 1st cycle. After the electrolyte abnormalities and the elevation of creatinine became normal, the patient received an additional three cycles of BEP and achieved complete remission. However, she also suffered from severe non-hematological toxicities, including grade 3 left ventricular dysfunction and grade 4 pulmonary fibrosis. In the case of rapidly progressing and high-volume YST treated with BEP chemotherapy, special attention should be paid to bleomycin-induced pulmonary toxicity following TLS. Further study is required to optimize drug exposure to ensure efficacy and reduce the risk of side effects in this population. PMID:22127348

Doi, Mihoko; Okamoto, Yohei; Yamauchi, Masami; Naitou, Hiroyuki; Shinozaki, Katsunori

2012-10-01

27

Endolymphatic sac tumor: a report of 3 cases and discussion of management.  

PubMed

Patients with an endolymphatic sac tumor (ELST) typically present with palsy of cranial nerves VII and/or VIII; other presenting symptoms include hearing loss, otalgia, occipital headaches, cranial nerve palsies, vertigo, gait ataxia, tinnitus, and otorrhea. ELSTs are extremely vascular, and they can invade and destroy temporal bone. Because of these characteristics, they are often mistaken for glomus tumors of the skull base. We describe the clinical presentation, evaluation, and management of ELSTs based on our review of the limited literature and our experience with 3 adults who presented to our tertiary care referral center with large ELSTs. Although these patients presented late in the course of their disease, their symptoms were relatively minor. Preoperative tumor embolization was performed, anda near-complete resection was achieved via an extended transotic approach in all 3 patients. The facial nerve was preserved without transposition in the first patient, the second patient underwent a primary nerve anastomosis, and the third required a cable graft of the facial nerve. Postoperative radiation therapy was administered to 2 of these patients. Follow-up by MRI detected no evidence of recurrence in any of the 3 patients. PMID:17315832

Doherty, Joni K; Yong, Mona; Maceri, Dennis

2007-01-01

28

Malignant peripheral nerve sheath tumor arising from the greater omentum: Case report  

Microsoft Academic Search

Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue tumors that arise from a peripheral nerve or exhibit\\u000a nerve sheath differentiation. Most of these tumors arise on the trunk, extremities, or head and neck regions; they are very\\u000a rarely located in the abdominal cavity. The patient was a 71-year-old man who was referred to our hospital for a mass

Masashi Miguchi; Yuji Takakura; Hiroyuki Egi; Takao Hinoi; Tomohiro Adachi; Yasuo Kawaguchi; Manabu Shinomura; Masakazu Tokunaga; Masazumi Okajima; Hideki Ohdan

2011-01-01

29

Extraosseous osteosarcoma arising in recurrent ossifying fibromyxoid tumor of soft tissue: a case report.  

PubMed

We present a case of an osteosarcoma arising in ossifying fibromyxoid tumor. The patient was a 50-year-old man when an initial tumor was identified. It was a soft tissue mass in the left popliteal area, measuring 14x9 cm. The tumor was surgically removed. Histologically, the primary tumor had the appearance of a conventional ossifying fibromyxoid tumor, although there were cellular areas with pleomorphism and high mitotic rate. The neoplasm recurred 4 times over the next 8 years, involving underlying tissues, including skeletal muscle and bone. The recurrent lesions features areas of osteoid, which increased with each recurrence and in the fourth recurrence the tumor had an appearance of extraskeletal osteosarcoma lacking the ossifying fibromyxoid tumor. The tumor generalized that killed the patient with widespread metastatic disease. PMID:23805469

Shelekhova, Ksenia V; Kazakov, Dmitri? V; Michal, Michal

2013-01-01

30

Pleomorphic hyalinizing angiectatic tumor arising in the thigh: A case report  

PubMed Central

Pleomorphic hyalinizing angiectatic tumors (PHATs) are rare non-metastasizing tumors of uncertain lineage. The current study presents a case of PHAT arising in the thigh of a 68-year-old female and examines the clinicopathological characteristics of the tumor. Magnetic resonance imaging (MRI) revealed an intramuscular mass located in the adductor longus. The tumor was surrounded by lipomatous tumor. Wide resectioning was performed for the internal tumor, whereas intralesional resectioning was performed for the external tumor. Histopathologically, the internal lesion was diagnosed as a PHAT and the external lesion was diagnosed as an hemosiderotic fibrolipomatous lesion (HFLL). No recurrence or metastases were identified during the 6-year follow-up period. As the adipose tissue surrounding the PHAT resembled a HFLL, therefore, the association between ‘early PHAT’ and HFLL is discussed. Although PHATs may represent low-grade sarcomas, HFLLs may be benign tumors. PMID:24944701

SUZUKI, KAYO; YASUDA, TAKETOSHI; HORI, TAKESHI; OYA, TAKESHI; WATANABE, KENTA; KANAMORI, MASAHIKO; KIMURA, TOMOATSU

2014-01-01

31

Malignant Peripheral Nerve Sheath Tumor Arising from an Adrenal Ganglioneuroma in a 6Yearold Boy  

Microsoft Academic Search

This report describes the youngest patient to develop a malignant peripheral nerve sheath tumor arising from a ganglioneuroma (MPNST ex Ganglioneuroma). The patient, a 6-year-old boy, was never irradiated and had no history or stigmata of neurofibromatosis. The report also includes a review of the previously published related cases, and an analysis of the immunohistochemistry and electron microscopy data available

Jean-Pierre de Chadarévian; Judy Mae Pascasio; Gregory E. Halligan; Douglas A. Katz; Joseph A. Locono; Stephen Kimmel; Christos D. Katsetos

2004-01-01

32

Superficial malignant peripheral nerve sheath tumor arising from diffuse neurofibroma in a neurofibromatosis type 1 patient.  

PubMed

Malignant peripheral nerve sheath tumors (MPNST) are regarded as sarcomas that arise from peripheral nerves or that display differentiation along the lines of the various elements of the nerve sheath. These tumors occur in deep soft tissues, but superficial primary MPNST with a cutaneous or subcutaneous origin have rarely been reported. A 70-year-old woman presented with a 3-4-year history of a slowly enlarging soft nodule on the left side of her neck. The histopathological diagnosis of the nodule was low-grade MPNST arising from diffuse neurofibroma. There was increased cellularity, but no necrosis or mitotic activity. These histopathological findings pose difficulties in differential diagnosis from a neurofibroma with atypical histological features. We report a rare case of superficial MPNST arising from diffuse neurofibroma associated with underlying occipital bone dysplasia in a neurofibromatosis type 1 patient. PMID:24942776

Inoue, Takuya; Kuwashiro, Maki; Misago, Noriyuki; Narisawa, Yutaka

2014-07-01

33

Solitary fibromastocytic tumor arising in an inguinal lymph node: the first description of a unique spindle cell tumor simulating mastocytosis.  

PubMed

A 77-yr-old man presented with a right inguinal mass. At herniotomy, an enlarged inguinal lymph node was also removed. Gross examination revealed a firm gray tumorous nodule measuring 3 cm in maximum diameter. On histological examination, the lymphatic tissue was found to have been almost completely replaced by spindle-shaped tumor cells arranged in whorls and bundles. In Giemsa-stained sections, about one-third of the tumor cells were seen to be strongly metachromatic tissue mast cells. The other tumor cells reacted only with a monoclonal antibody against vimentin out of a broad panel of antibodies directed against various antigens expressed by leukocytes, mesenchymal cells, and epithelial cells. A small fraction of the nonmetachromatic tumor cells reacted with the proliferation-associated antibody MIB1. Immunostaining with an antibody against p53 tumor-suppressor gene products was negative. Electron-microscopic examination revealed mast cells containing abundant granules, which were intermingled with fibroblasts that had bizarre, elongated nuclei. No myofibroblasts, desmosomes, or basement membrane material were detected. Clinical examination revealed no abnormalities, and blood and bone marrow findings were completely normal. A diagnosis of solitary (apparently benign) fibromastocytic tumor was established on the basis of the relative tumor cell numbers, the cytological features, and the clinical data. To the authors' knowledge, this is the first description of a solitary spindle cell tumor arising in a lymph node and simulating mastocytosis. PMID:7892167

Horny, H P; Rabenhorst, G; Löffler, H; Kaiserling, E

1994-12-01

34

Tumor like swellings arising from Hoffa's fat pad: A report of three patients  

PubMed Central

We report three rare cases of tumor-like conditions arising from Hoffa's fat pad (HFP). Patients were having persistent knee pain, the cause of which was not diagnosed by the general physician, and then were referred to us for knee pain. Magnetic resonance imaging revealed the lesions to be arising from HFP (ganglion cysts and hemangioma), as was suggested by clinical findings. Anatomy, pathology, and radiological features of the Hoffa's disease are described here to increase awareness in orthopedic community of this rare but interesting disease which is often misdiagnosed as meniscal pathology. These cases illustrate that increased cognizance can facilitate timely intervention which will prevent morbidity of the patient. PMID:22719128

Ghate, Sushant D; Deokar, Bhupal N; Samant, Ashwin V; Kale, Satish P

2012-01-01

35

A case of endolymphatic sac tumor with long-term survival  

Microsoft Academic Search

A 72-year-old man developed left facial palsy at age 14 and left-sided hearing loss at age 20. At the age of 59, he presented\\u000a with gait disturbance, and a large left cerebellopontine angle tumor was detected, which had markedly destroyed the pyramidal\\u000a bone. The tumor was subtotally resected, but he required two more operations at the ages of 64 and

Kenichiroh Asano; Tetsuji Sekiya; Toru Hatayama; Masahiko Tanaka; Atsuhito Takemura; Shigeharu Suzuki; Osami Kubo; Yoshihiro Ishihara

1999-01-01

36

Endoscopic full-thickness resection for gastric submucosal tumors arising from the muscularis propria layer  

PubMed Central

AIM: To evaluate the efficacy, safety and feasibility of endoscopic full-thickness resection (EFR) for the treatment of gastric submucosal tumors (SMTs) arising from the muscularis propria. METHODS: A total of 35 gastric SMTs arising from the muscularis propria layer were resected by EFR between January 2010 and September 2013. EFR consists of five major steps: injecting normal saline into the submucosa; pre-cutting the mucosal and submucosal layers around the lesion; making a circumferential incision as deep as the muscularis propria around the lesion using endoscopic submucosal dissection and an incision into the serosal layer around the lesion with a Hook knife; a full-thickness resection of the tumor, including the serosal layer with a Hook or IT knife; and closing the gastric wall with metallic clips. RESULTS: Of the 35 gastric SMTs, 14 were located at the fundus, and 21 at the corpus. EFR removed all of the SMTs successfully, and the complete resection rate was 100%. The mean operation time was 90 min (60-155 min), the mean hospitalization time was 6.0 d (4-10 d), and the mean tumor size was 2.8 cm (2.0-4.5 cm). Pathological examination confirmed the presence of gastric stromal tumors in 25 patients, leiomyomas in 7 and gastric autonomous nerve tumors in 2. No gastric bleeding, peritonitis or abdominal abscess occurred after EFR. Postoperative contrast roentgenography on the third day detected no contrast extravasation into the abdominal cavity. The mean follow-up period was 6 mo, with no lesion residue or recurrence noted. CONCLUSION: EFR is efficacious, safe and minimally invasive for patients with gastric SMTs arising from the muscularis propria layer. This technique is able to resect deep gastric lesions while providing precise pathological information about the lesion. With the development of EFR, the indications of endoscopic resection might be extended.

Huang, Liu-Ye; Cui, Jun; Lin, Shu-Juan; Zhang, Bo; Wu, Cheng-Rong

2014-01-01

37

Transcardiac tunneling technique for endoscopic submucosal dissection of gastric fundus tumors arising from the muscularis propria.  

PubMed

The promising endoscopic resection techniques for upper gastrointestinal submucosal tumors (SMTs) are challenged when performed in the gastric fundus. Here, we report on the development of a transcardiac endoscopic tunneling technique (TCTT) for the resection of tumors in this area. A total of 18 patients with gastric fundus SMTs arising from the muscularis propria on endoscopic ultrasound underwent TCTT. The procedure involved the excavation of a submucosal tunnel from the esophagus, through the cardia, to the gastric SMT for resection. The tunnel was closed by clips after retrieval of the tumor. The mean tumor size was 2.1?cm (range 0.8?-?5.0?cm). The mean procedure time was 75.1 minutes (range 40?-?100 minutes). Complete resection was achieved in all cases. Iatrogenic perforation occurred in one case. This and one other patient developed mild pneumoperitoneum on the day after the procedure; symptoms resolved under conservative management. No patient developed gastrointestinal leakage, delayed bleeding, or secondary infection. Therefore, in this pilot study, TCTT provided a definitive histological diagnosis as well as a feasible, safe, and easy therapeutic approach for gastric fundus SMTs arising from muscularis propria in the circular area within 8?cm below the cardia. PMID:25036658

Lu, Jiaoyang; Zheng, Minhua; Jiao, Taotao; Wang, Yanan; Lu, Xuefeng

2014-10-01

38

Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament.  

PubMed

Tenosynovial giant cell tumors originate from the synovial tissue of the joints, tendon sheaths, mucosal bursas, and fibrous tissues adjacent to tendons. The disease presents in localized and diffused forms. Large joints, such as the knee, are not frequently affected. Magnetic resonance imaging has been reported to be the best noninvasive technique to diagnose these tumors. Magnetic resonance imaging diagnosis has to be confirmed by histopathological examination. Few reports exist of tenosynovial giant cell tumors arising from the posterior cruciate ligament. This article describes a case of an 18-year-old man with no history of trauma but with a 2-year history of mild, ongoing, and worsening right knee pain and swelling localized in the popliteal region. Clinical examination of the knee was negative. Magnetic resonance imaging revealed an intra-articular mass measuring 4.8×2.1×2.7 cm in the posterior region of the knee attached to the posterior cruciate ligament. Arthroscopy was performed using the posterior approach through the posterolateral and posteromedial portals. A specimen of the lesion was removed arthroscopically for histopathological examination, and a wide resection of the mass was performed with a shaver and a radiofrequency ablation device. Histopathological examination confirmed the diagnosis of a tenosynovial giant cell tumor. No recurrence had occurred at 2-year follow-up. Magnetic resonance imaging and histopathological examination may help in achieving a correct diagnosis, and arthroscopic excision using a posterior approach may be the treatment of choice by surgeons. PMID:22784912

Camillieri, Gianluca; Di Sanzo, Vincenzo; Ferretti, Matteo; Calderaro, Cosma; Calvisi, Vittorio

2012-07-01

39

[Testicular tumor arising in intra-abdominal testis which was not detected at prior orchidopexy : a case report].  

PubMed

A 35-year-old man with an intra-abdominal testicular tumor arising from the right unresolved intraabdominal testis is reported. At 10 years old, left orchidopexy was successfully performed for bilateral undescended testes. However, the right testis was not detected during the operation, and it was diagnosed as vanishing testis. Twenty-five years later, he was referred to our hospital with the complaint of right lower abdominal pain. Computed tomography revealed huge pelvic tumors and bulky para-aortic lymph node swellings. Histopathologic examination of the needle biopsy specimen obtained from the pelvic tumor revealed seminomatous germ cell tumor. Taking the results with a tumor marker study into consideration, the patient was tentatively diagnosed with non-seminomatous germ cell tumor NSGCT (stage IIB) arising from the unresolved intra-abdominal testis or extragonadal germ cell tumor. He received 3 courses of bleomycin, etoposide, cisplatin (BEP), and 4 courses of VP-16, ifosfamide, cisplatin (VIP). After chemotherapy, we performed tumorectomy and retroperitoneal lymphadenectomy because tumor markers were normalized and 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET)-CT revealed normalization. We identified the pelvic tumor as an intra-abdominal testicular tumor arising from right unresolved intra-abdominal testis. Pathological examination revealed no residual tumor cells. There has been no recurrence 17 months after surgery. PMID:23633636

Iwamura, Hiromichi; Hatakeyama, Shingo; Fukushi, Ken; Sato, Tendo; Kojima, Yuta; Murasawa, Hiromi; Ishimura, Hirofumi; Yoneyama, Takahiro; Koie, Takuya; Kamimura, Noritaka; Morobashi, Satoko; Kijima, Hiroshi; Ohyama, Chikara

2013-03-01

40

Single-incision laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor arising from the duodenum.  

PubMed

We report a case involving a minimally invasive single-incision laparoscopic and endoscopic cooperative local excision of a duodenal gastrointestinal stromal tumor. A 59-year-old man presented with a 35-mm lesion located in the second portion of the duodenum. A local resection was performed via single-incision laparoscopic and endoscopic cooperative surgery. Intraluminal endoscopic dissection of the duodenal mucosa and submucosa was performed circumferentially around the tumor. The resection was then completed by laparoscopic dissection of the seromuscular layer around the tumor. The tumor was retrieved laparoscopically. After confirming that the resection achieved clear surgical margins, we closed the duodenal wall with a laparoscopic stapling device. There were no postoperative complications, including stenosis. Single-incision laparoscopic and endoscopic cooperative surgery can be safely and effectively performed for a duodenal submucosal tumor. PMID:24308591

Ohi, Masaki; Yasuda, Hiromi; Ishino, Yoshito; Katsurahara, Masaki; Saigusa, Susumu; Tanaka, Kyosuke; Tanaka, Koji; Mohri, Yasuhiko; Inoue, Yasuhiro; Uchida, Keiichi; Kusunoki, Masato

2013-11-01

41

Case Report Carcinoid Tumors Arising in Tailgut Cysts May Be Associated with Estrogen Receptor Status: Case Report and Review of the Literature  

Microsoft Academic Search

Tailgut cysts are uncommon developmental cysts that form in the presacral space. Complications of tailgut cysts include benign reactive lesions associated with infection and inflammation, and malignant transformation. Six cases of carcinoid tumor arising in tailgut cysts have been reported in the medical literature to date. Here we report another case of carcinoid tumor arising in a tailgut cyst. Because

John J. Liang; Sadir Alrawi; Gregory N. Fuller; Dongfeng Tan

42

Sudden Unilateral Vision Loss Arising from Calcified Amorphous Tumor of the Left Ventricle  

PubMed Central

Calcified amorphous tumor of the heart is a very rare non-neoplastic intracavitary mass. The clinical presentation is similar to that of other cardiac masses. The precise cause and best approach to treatment remain unclear. We describe a case of cardiac calcified amorphous tumor presenting with refractory unilateral vision loss that was successfully treated by surgical excision. To our knowledge, this is only the 2nd reported case of retinal arterial embolism due to cardiac calcified amorphous tumor in the English-language literature. PMID:24082378

Nazli, Yunus; Colak, Necmettin; Atar, Inci Asli; Alpay, Mehmet Fatih; Haltas, Hacer; Eryonucu, Beyhan; Cakir, Omer

2013-01-01

43

A Pancreatic Head Tumor Arising as a Duodenal GIST: A Case Report and Review of the Literature  

PubMed Central

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the gastrointestinal tract that originate from the intestinal cells of Cajal (ICC) (Fletcher et al., 2002). Only a few cases have been described with extragastrointestinal stromal tumors (Kim et al., 2012; Soufi et al., 2013; Meng et al., 2011). They are often diagnosed as a pancreatic head tumor as they are very difficult to relate to the duodenum with CT, MRI, or ultrasound. We present a case of a sixty-four-year-old woman who presented with abdominal pain and cardialgia for a follow-up examination after breast cancer surgery. On laparotomy there was a 3?×?5?cm hypervascular mass arising from the pancreatic head with macroscopically no attachment to the duodenum. The patient underwent pancreatoduodenectomy (PD) modified after Traverso-Longmire, histopathology proved a duodenal GIST. This case proves that duodenal GISTs can grow invasively into the pancreas and appear as solid pancreas head tumor; therefore, these tumors should be included into differential diagnosis.

Bormann, Fabian; Wild, Wolfgang; Aksoy, Huseyin; Dorr, Pius; Schmeck, Sanja; Schwarzbach, Matthias

2014-01-01

44

Hepatocellular carcinoma arising in adenoma: similar immunohistochemical and cytogenetic features in adenoma and hepatocellular carcinoma portions of the tumor.  

PubMed

Well-differentiated hepatocellular carcinoma in non-cirrhotic liver can show morphological features similar to hepatocellular adenoma. In rare instances, hepatocellular carcinoma can arise in the setting of hepatocellular adenoma. This study compares the immunohistochemical and cytogenetic features of the hepatocellular adenoma-like and hepatocellular carcinoma portions of these tumors. Immunohistochemistry for ?-catenin, glutamine synthetase, serum amyloid A protein, glypican-3, and heat-shock protein 70 was done in 11 cases of hepatocellular carcinoma arising in hepatocellular adenoma in non-cirrhotic liver. Tumors with nuclear ?-catenin and/or diffuse glutamine synthetase were considered ?-catenin activated. Fluorescence in situ hybridization (FISH) was done in nine cases for gains of chromosomes 1, 8 and MYC. There were seven men (33-75 years) and four women (29-65 years). Focal atypical morphological features were seen in hepatocellular adenoma-like areas in 7 (64%) cases. Hepatocellular adenoma-like areas showed features of inflammatory hepatocellular adenoma in 7 (64%) cases; 4 of these were also serum amyloid A-positive in the hepatocellular carcinoma portion. ?-Catenin activation, heat-shock protein 70 positivity, and chromosomal gains on FISH were seen in the hepatocellular adenoma portion in 55%, 40%, and 56% of cases, and 73%, 60%, and 78% of cases in the hepatocellular carcinoma portion, respectively. In conclusion, the hepatocellular adenoma-like portion of most cases of hepatocellular carcinoma arising in hepatocellular adenoma shows features typically seen in hepatocellular carcinoma such as focal morphological abnormalities, ?-catenin activation, heat-shock protein 70 expression, and chromosomal gains. Hepatocellular adenoma-like areas in these tumors, especially in men and older women, may represent an extremely well-differentiated variant of hepatocellular carcinoma, whereas the morphologically recognizable hepatocellular carcinoma portion represents a relatively higher grade component of the tumor. PMID:24743216

Kakar, Sanjay; Grenert, James P; Paradis, Valerie; Pote, Nicolas; Jakate, Shriram; Ferrell, Linda D

2014-11-01

45

Extra-abdominal fibromatosis (desmoid tumor): a rare tumor of the lower extremity arising from the popliteal fossa.  

PubMed

Aggressive fibromatosis is a rare soft tissue tumor. Although it lacks metastatic potential, it can grow aggressively in a locally infiltrating pattern. The tumors frequently recur after surgical excision, which remains the treatment of choice. Optional combinations of radiotherapy and/or chemotherapy have been used postoperatively for recurrent disease and/or inoperable cases. A palpable mass was detected in the popliteal fossa of the right lower extremity in a 48-year-old man. Magnetic resonance imaging showed a contrast-enhancing noncalcified lesion initially felt to represent a vascular tumor. An invasive mass adherent to the surrounding tissue was visualized intraoperatively and extensively debulked. The patient's postoperative course was uneventful. Histologic examination of the surgical specimen was consistent with an extra-abdominal desmoid tumor. After appropriate recognition, wide local excision may be the most appropriate treatment for fibromatosis of the extremity. However, the rarity of this tumor and the difficulty inherent in distinguishing it from similar-appearing tumors are necessitating histologic confirmation of the diagnosis. PMID:22937461

Ali Kaygin, Mehmet; Dag, Ozgur; Erkut, Bilgehan; Ates, Azman; Kayaoglu, Refik Cetin; Kadioglu, Hakan

2011-01-01

46

Solitary fibrous tumor arising slowly in the vulva over 10 years: case report and review.  

PubMed

Solitary fibrous tumor (SFT), which was first described as a pleural lesion by Klemperer and Rabin in 1931, is a rare, slow-growing neoplasm characterized by the proliferation of fibroblast-like spindle cells arranged in a patternless manner with few nuclear atypia. Extrathoracic SFT have increasingly been recognized, but those in the genital tract are extremely rare. Gynecological SFT behave as tumors with low malignant potential to recur, metastasize, or affect nearby organs resulting in infertility. We report a case of vulvar SFT slowly growing for 10 years, and propose a strategy for the diagnosis and treatment of gynecological SFT. PMID:22449361

Taki, Mana; Baba, Tsukasa; Mandai, Masaki; Suzuki, Ayako; Mikami, Yoshiki; Matsumura, Noriomi; Konishi, Ikuo

2012-05-01

47

Human skin carcinoma arising from kidney transplant-derived tumor cells  

PubMed Central

Tumor cells with donor genotype have been identified in human skin cancer after allogeneic transplantation; however, the donor contribution to the malignant epithelium has not been established. Kidney transplant recipients have an increased risk of invasive skin squamous cell carcinoma (SCC), which is associated with accumulation of the tumor suppressor p53 and TP53 mutations. In 21 skin SCCs from kidney transplant recipients, we systematically assessed p53 expression and donor/recipient origin in laser-microdissected p53+ tumor cells. In one patient, molecular analyses demonstrated that skin tumor cells had the donor genotype and harbored a TP53 mutation in codon 175. In a kidney graft biopsy performed 7 years before the skin SCC diagnosis, we found p53+ cells in the renal tubules. We identified the same TP53 mutation in these p53+ epithelial cells from the kidney transplant. These findings provide evidence for a donor epithelial cell contribution to the malignant skin epithelium in the recipient in the setting of allogeneic kidney transplantation. This finding has theoretical implications for cancer initiation and progression and clinical implications in the context of prolonged immunosuppression and longer survival of kidney transplant patients. PMID:23979160

Verneuil, Laurence; Varna, Mariana; Ratajczak, Philippe; Leboeuf, Christophe; Plassa, Louis-Francois; Elbouchtaoui, Morad; Schneider, Pierre; Sandid, Wissam; Lebbe, Celeste; Peraldi, Marie-Noelle; Sigaux, Francois; de The, Hugues; Janin, Anne

2013-01-01

48

Cellular schwannoma arising from the gastric wall misdiagnosed as a gastric stromal tumor: A case report  

PubMed Central

Cellular schwannomas have been previously described at almost every anatomic location of the human body, but reports in the gastric wall are rare. The current study presents a rare case of cellular schwannoma originating from the gastric wall. Computed tomography revealed a 5.6×5.3×4.0-cm3 solid mass located in the posterior wall of the stomach. Open laparotomy confirmed its mesenchymal origin. Microscopically, the tissue was composed of spindle-shaped and fascicularly-arranged cells, but mitotic figures were rare. Immunohistochemical staining showed that the tumor was negative for cluster of differentiation (CD)117, CD34, smooth muscle actin and desmin, but positive for S-100 and Ki67. The patient presented no evidence of recurrence and metastasis during follow-up. Gastric cellular schwannomas may be diagnosed by clinical characteristics, histological observations and immunohistochemical markers. PMID:24396458

WANG, GUANGYAO; CHEN, PING; ZONG, LIANG; SHI, LEI; ZHAO, WEI

2014-01-01

49

Concurrent Malignant Solitary Fibrous Tumor Arising from the Omentum and Grade 3 Endometrial Endometrioid Adenocarcinoma of the Uterus with p53 Immunoreactivity  

PubMed Central

A malignant solitary fibrous tumor arising from the omentum is extremely rare. To our knowledge, this is the first case of a malignant solitary fibrous omentum tumor coexisting with uterine corpus cancer. A 62-year-old woman presented to our hospital with vaginal discharge. Endometrioid adenocarcinoma was diagnosed by endometrial curettage. In addition, a solid tumor in front of the uterus was detected following computed tomography and/or magnetic resonance imaging, which was suspected to be a primary (or secondary) malignant tumor arising from the omentum. Hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and lymphadenectomy were performed. A malignant solitary fibrous tumor of the omentum and grade 3 endometrioid adenocarcinoma of the uterus were diagnosed by pathohistological analysis. Interestingly, the tumor cells were immunoreactive for p53. Adjuvant chemotherapy was administered for the uterine corpus cancer and the patient remains healthy 48 months after the surgery. These tumors may have become malignant due to the presence of p53 mutations. PMID:25114818

Nobuhara, Ichiro; Haruta, Noriko; Higashiura, Yumi; Watanabe, Hideki; Ohno, Sumire

2014-01-01

50

Concurrent Malignant Solitary Fibrous Tumor Arising from the Omentum and Grade 3 Endometrial Endometrioid Adenocarcinoma of the Uterus with p53 Immunoreactivity.  

PubMed

A malignant solitary fibrous tumor arising from the omentum is extremely rare. To our knowledge, this is the first case of a malignant solitary fibrous omentum tumor coexisting with uterine corpus cancer. A 62-year-old woman presented to our hospital with vaginal discharge. Endometrioid adenocarcinoma was diagnosed by endometrial curettage. In addition, a solid tumor in front of the uterus was detected following computed tomography and/or magnetic resonance imaging, which was suspected to be a primary (or secondary) malignant tumor arising from the omentum. Hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and lymphadenectomy were performed. A malignant solitary fibrous tumor of the omentum and grade 3 endometrioid adenocarcinoma of the uterus were diagnosed by pathohistological analysis. Interestingly, the tumor cells were immunoreactive for p53. Adjuvant chemotherapy was administered for the uterine corpus cancer and the patient remains healthy 48 months after the surgery. These tumors may have become malignant due to the presence of p53 mutations. PMID:25114818

Harada, Naoya; Nobuhara, Ichiro; Haruta, Noriko; Higashiura, Yumi; Watanabe, Hideki; Ohno, Sumire

2014-01-01

51

Malignant peripheral nerve sheath tumor arising from the colon in a newborn: report of a case and review of the literatures  

Microsoft Academic Search

A malignant peripheral nerve sheath tumor (MPNST) is a rare neoplasm arising from peripheral nerve sheath. Here, we report the first case of MPNST arising in the colon and also the youngest case of MPNST in the gastrointestinal tract. The patient was a 2-day-old neonate with symptoms and signs of intestinal obstruction. The patient had no family history or stigmata

Young-Joon Lee; HyeongGon Moon; Soon-Tae Park; Woo-Song Ha; Sang-Gyeong Choi; Soon-Chan Hong; Young-Tae Joo; Chi-Young Jeong; Eun-Jung Jung

2006-01-01

52

The histogenic origin of melanoma arising in respiratory epithelium of a teratomatous germ cell tumor of the mediastinum: an enigma unraveled from an unlikely source  

PubMed Central

Mixed germ cell tumors are rare neoplasms that are known to occur in the anterior mediastinum. Characterized by two or more types of germ cell components, these tumors comprise upwards of 25% of mediastinal germ cell tumors. Even rarer are those harboring somatic-type malignancies such as carcinoma, sarcoma, and hematopoietic malignancies. To date, however, there are no known cases of melanoma arising in a malignant mixed germ cell tumor of the anterior mediastinum. We describe the first case of malignant melanoma with spindle and epithelioid components arising from respiratory epithelium in a mediastinal malignant mixed germ cell tumor of a 32-year-old male. In addition, we also provide evidence supporting the theory of neuroendocrine cells as the origin of melanoma arising in the respiratory epithelium. This case emphasizes the need to carefully evaluate all germ cell tumors, not only for a myriad of benign embryological components, but also for malignancies arising in these components, as they might change the prognosis and patient’s course of treatment. This microscopic approach should bring to light the diversity of mixed germ cell tumors in addition to somatic malignancies with corresponding biologic potentials. PMID:23119117

McNab?, Patricia; Quigley, Brian; Mendoza, Tania; Hakam, Ardeshir; Khalil, Farah; Fishman, Mayer; Altiok, Soner

2012-01-01

53

Low-grade neuroendocrine tumors arising in intestinal adenomas: evidence for alterations in the adenomatous polyposis coli/?-catenin pathway.  

PubMed

Low-grade neuroendocrine tumors (NETs) arising in intestinal adenomas are rare. They are occasionally observed in patients with familial adenomatous polyposis (FAP), suggesting a role for the adenomatous polyposis coli/?-catenin pathway. We identified 25 composite adenoma/low-grade NETs from colorectum (21) and duodenum (4) and evaluated their clinicopathological features, survival, and nuclear ?-catenin expression by immunohistochemistry. ?-catenin staining was scored as % positivity × intensity (weak, 1; moderate, 2; and strong, 3), for a total possible score of 300. Control groups included 1781 adenomas without NET, 63 composite adenoma/high-grade neuroendocrine carcinomas (NECs), and 32 sporadic NETs. Among 25 adenoma/low-grade NETs, 4 (16%) occurred in patients with FAP. Size of the NET component ranged from 0.01 to 0.9 cm (mean, 0.32 cm). Most (84%) arose in "advanced" adenomas (size >1 cm, villous architecture [72%], or high-grade dysplasia [56%]). In contrast, villous architecture and high-grade dysplasia were present in only 14% (P < .001) and 7% (P < .001), respectively, of adenomas without NET. Overall survival with adenoma/low-grade NET was significantly higher than adenoma/high-grade NEC but significantly lower than sporadic NET (P < .001). Higher ?-catenin expression was seen in adenoma/low-grade NETs (mean score, 231) compared with sporadic NETs (mean score, 48; P < .0001) and adenoma/high-grade NEC (mean score, 173; P = .04). In summary, composite adenoma/low-grade NETs most commonly occur with advanced polyps, but the NET component itself is generally small and indolent. In contrast to sporadic NETs, the occurrence of these lesions in FAP and their high levels of nuclear ?-catenin expression support a pathogenic role for the adenomatous polyposis coli/?-catenin pathway. PMID:25149552

Estrella, Jeannelyn S; Taggart, Melissa W; Rashid, Asif; Abraham, Susan C

2014-10-01

54

SAC Minutes May 28, 2014 SAC Members & Alternate Members present  

E-print Network

SAC Minutes � May 28, 2014 1 SAC Members & Alternate Members present: Delegated Office Director Mary Smith NIDCD Zelia Pulliam ASRB Nic D'Ascoli NIDCR Jimmy Sanders BPA Zedekiah Worsham #12;SAC; and NBS Systems Holds Job Aid. 4. The next Simplified Acquisition Committee (SAC) Meeting will be held

Rau, Don C.

55

Endoscopic Ultrasound-Assisted Tunnel-Type Endoscopic Submucosal Dissection for the Treatment of Esophageal Tumors Arising in the Muscularis Propria (with video)  

PubMed Central

Objective: Esophageal tumors arising in the muscularis propria are difficult to be resected endoscopically using standard electro-surgical techniques, even the endoscopic submucosal dissection (ESD) technique appeared recently. Our purpose is to investigate the efficacy of endoscopic ultrasound (EUS)-assisted tunnel-type ESD for resection of these tumors. Methods: A total of 17 patients were included in this study. A standard endoscope was used. The submucosal tunnel was created with the triangle knife according to the standard ESD technique, about 5 cm proximal to the lesion. EUS was performed within the tunnel to detect the tumor, and then the tumor was separated both from the submucosal and the muscle layers. After the tumor was removed, several clips were used to close the mucosal defect. EUS was performed to evaluate the healing quality 1 week after the procedure. Result: In all the cases, the tumors were completely resected. Mean tumor size was 24.2 mm (12-50 mm) in diameter. The histo-logical diagnoses were leiomyoma (16/17) and gastrointestinal stromal tumor (GIST, 1/17). Subcutaneous emphysema was found in 2 patients after the procedure, but disappeared by the third day. No patients sustained perforation or developed significant hem-orrhage, and there were no other immediate severe complications after the procedure. The healing quality was satisfying in 16/17 patients evaluated by EUS 1 week after the procedure. No recurrence has been found during follow-up (mean 7 months, range 3-13 months). Conclusion: EUS-assisted tunnel-type ESD is effective and safe in treatment of esophageal tumors arising in the muscularis pro-pria. PMID:24949361

Ge, Nan; Sun, Siyu; Wang, Sheng; Liu, Xiang; Wang, Guoxin; Guo, Jintao

2013-01-01

56

Concurrent primary carcinoid tumor arising within mature teratoma and clear cell renal cell carcinoma in the horseshoe kidney: report of a rare case and review of the literature  

PubMed Central

Primary carcinoid tumor arising in a mature teratoma of the horseshoe kidney is exceptionally rare and only 4 such cases have been reported in the world literature to date. The simultaneous occurrence of different subtypes of renal cell carcinoma (RCC) or RCC coexistence with non-RCC neoplasms from the same kidney is unusual and infrequently reported. Herein we report a case of primary carcinoid tumor arising within mature teratoma, concurrent with a clear cell RCC in the horseshoe kidney of a 37-year-old man. Histologically, both the carcinoid tumor and clear cell RCC demonstrated the characteristic morphology in their classic forms. In addition to the carcinoid tumor, the mature teratoma consisted of variably sized, large cystic spaces lined by cytologically bland mucinous columnar epithelium, pseudostratified columnar epithelium, ciliated epithelium and mature smooth muscle fibers were also identified within the cystic wall. Furthermore, foci of round, small nodules composed of mature prostatic acinus were noted in the teratoma which was confirmed by exhibiting strong immunoreactivity for prostate specific antigen. The present case serves to expand the histologic component that may be encountered in the mature terotoma of the kidney and further broadens the spectrum of primary tumors occurring in the horseshoe kidney. PMID:24228123

Sun, Ke; You, Qihan; Zhao, Ming; Yao, Hongtian; Xiang, Hua; Wang, Lijun

2013-01-01

57

Concurrent primary carcinoid tumor arising within mature teratoma and clear cell renal cell carcinoma in the horseshoe kidney: report of a rare case and review of the literature.  

PubMed

Primary carcinoid tumor arising in a mature teratoma of the horseshoe kidney is exceptionally rare and only 4 such cases have been reported in the world literature to date. The simultaneous occurrence of different subtypes of renal cell carcinoma (RCC) or RCC coexistence with non-RCC neoplasms from the same kidney is unusual and infrequently reported. Herein we report a case of primary carcinoid tumor arising within mature teratoma, concurrent with a clear cell RCC in the horseshoe kidney of a 37-year-old man. Histologically, both the carcinoid tumor and clear cell RCC demonstrated the characteristic morphology in their classic forms. In addition to the carcinoid tumor, the mature teratoma consisted of variably sized, large cystic spaces lined by cytologically bland mucinous columnar epithelium, pseudostratified columnar epithelium, ciliated epithelium and mature smooth muscle fibers were also identified within the cystic wall. Furthermore, foci of round, small nodules composed of mature prostatic acinus were noted in the teratoma which was confirmed by exhibiting strong immunoreactivity for prostate specific antigen. The present case serves to expand the histologic component that may be encountered in the mature terotoma of the kidney and further broadens the spectrum of primary tumors occurring in the horseshoe kidney. PMID:24228123

Sun, Ke; You, Qihan; Zhao, Ming; Yao, Hongtian; Xiang, Hua; Wang, Lijun

2013-01-01

58

Malignant peripheral nerve-sheath tumor arising in a previously irradiated neuroblastoma: report of 2 cases and a review of the literature  

Microsoft Academic Search

Background. Only ten cases of the rare occurrence of a malignant peripheral nerve-sheath tumor (MPNST) arising in a ganglioneuroma either\\u000a de novo or at a site of previous irradiation have been reported.\\u000a \\u000a \\u000a Patients and methods. We present two children who at the age of 19 months and 6 months were diagnosed with a cervicothoracic ganglioneuroblastoma\\u000a and a retroperitoneal neuroblastoma, respectively.

Oscar Navarro; E. Nunez-Santos; A. Daneman; P. Faria; P. Daltro

2000-01-01

59

Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization.  

PubMed

Carcinoma arising from Warthin tumor is extremely rare. A 79-year-old man was admitted for a firm, well-defined, 5-cm left infra-auricular mass. Aspiration cytology showed many lymphohistiocytes and oncocytes in a proteinaceous background, compatible with Warthin tumor. A left superficial parotidectomy showed a solid mass around the cyst wall. The tumor cells of the solid area were arranged as infiltrative ducts with a few foci of malignant transformation. Virtual karyotyping disclosed a complex pattern of genetic aberrations with a focal amplification in 12q14-q21.2. This chromosomal region contains the MDM2 (murine double minute) gene, which regulates p53 inactivation. HER2 fluorescence in situ hybridization showed a focal amplification. Subsequently, the patient underwent total parotidectomy and ipsilateral neck dissection for a recurrence. To our knowledge, this is the first case of salivary duct carcinoma arising from Warthin tumor. The essential molecular pathway has not been reported, we presume an important role of MDM2 amplification- P53 inactivation. PMID:21877991

Kim, Hyun-Jung; Yoo, Young Sam; Park, Kyeongmee; Kwon, Ji-Eun; Kim, Jung Yeon; Monzon, Federico A

2011-09-01

60

Synchronous primary carcinoid tumor and primary adenocarcinoma arising within mature cystic teratoma of horseshoe kidney: a unique case report and review of the literature  

PubMed Central

Background Malignant transformation of mature cystic teratoma is a rare complication. While any of the constituent tissues of a teratoma has the potential to undergo malignant transformation, squamous cell carcinoma is the most commonly associated malignancy. Renal carcinoid tumors are rare and frequently associated with horseshoe kidney and renal teratoma. Renal teratoma rarely presents together with carcinoid tumor or adenocarcinoma. To the best of our knowledge, there has never been a report of renal teratoma coexisting with both carcinoid tumor and adenocarcinoma. Methods Here, we present a unique and first case of synchronous primary carcinoid tumor and moderately differentiated adenocarcinoma arising within mature cystic teratoma of horseshoe kidney in a 50-year-old female. Lumbar spine X-ray, done for her complaint of progressive chronic low back pain, accidentally found a large calcification overlying the lower pole of the right kidney. Further radiologic studies revealed horseshoe kidney and a large multiseptated cystic lesion immediately anterior to the right renal pelvis with central calcification and peripheral enhancement. She underwent right partial nephrectomy. Results Macroscopically, the encapsulated complex solid and multiloculated cystic tumor with large calcification, focal thickened walls and filled with yellow-tan gelatinous material. Microscopically, the tumor showed coexistent mature cystic teratoma, moderately differentiated adenocarcinoma and carcinoid tumor. Immunohistochemically, alpha-methylacyl-coenzyme A-racemase, calretinin, CD10 and thyroid transcription factor-1 were negative in all the three components of the tumor. The teratomatous cysts lined by ciliated epithelium showed strong staining for cytokeratin 7 and pancytokeratin, and those lined by colonic-like epithelium showed strong staining for CDX2, cytokeratin 20 and pancytokeratin, but both were negative for calretinin. Additionally, the teratomatous cyst wall showed strong staining for smooth muscle actin, and weak staining for carbonic anhydrase IX, CD99, chromogranin and synaptophysin. The adenocarcinoma component was strongly positive for cytokeratin 7 and pancytokeratin, weakly positive for synaptophysin and CD56, and negative for carbonic anhydrase IX, CD99, CDX2, chromogranin, cytokeratin 20 and smooth muscle actin. The carcinoid tumor component was strongly positive for CD56, chromogranin and synaptophysin, weakly positive for pancytokeratin, and negative for carbonic anhydrase IX, CD99, CDX2, cytokeratin 7, cytokeratin 20 and smooth muscle actin. She received no adjuvant therapy and is alive without evidence of disease six months after diagnosis and surgery. Conclusion This unique and first case herein presented with synchronous primary carcinoid tumor and primary adenocarcinoma arising within mature cystic teratoma of horseshoe kidney emphasizes the need for thorough sectioning and entire submission for histologic evaluation of mature cystic teratomas, in order to avoid missing multiple additional histogenetically distinct neoplasms. PMID:19523243

Armah, Henry B; Parwani, Anil V; Perepletchikov, Aleksandr M

2009-01-01

61

Exceptionally large solitary fibrous tumor arising from the cheek: an immunohistochemical and ultrastructural study with a review of the literature.  

PubMed

Solitary fibrous tumor (SFT) is a rare mass-forming soft tissue tumor that occurs most commonly in the pleura, but has been described in various extrathoracic sites. Extrapleural manifestation of SFT, particularly in the head and neck region, is rare. The most common extrapleural site is the oral cavity; these tumors have also been described in the orbit, nasopharynx, paranasal sinuses, salivary glands, and larynx. We report an extremely rare case of a SFT in the subcutaneous region of the cheek. This tumor in the left cheek was a large firm mass, approximately 8.5 cm × 6 cm in size and was successfully treated by surgical resection. Immunohistochemistry revealed reactivity for vimentin, CD34, and bcl-2, but no staining for cytokeratin, epithelial membrane antigen, S-100, desmin, caldesmon, actin, ?-smooth muscle actin, CD117, and CD99. Immunohistochemical study is the key to establish a definitive diagnosis of SFT, and ultrastructural study is also useful for making an accurate diagnosis. The patient recovered uneventfully without evidence of tumor recurrence 2 years after surgery. PMID:24221815

Satomi, Takafumi; Hasegawa, On; Abukawa, Harutsugu; Kohno, Michihide; Enomoto, Ai; Chikazu, Daichi; Matsubayashi, Jun; Nagao, Toshitaka

2014-06-01

62

Solitary Fibrous Tumor arising in extremity: A report of two cases with 201Thallium Scintigraphic and PET findings  

Microsoft Academic Search

Summary We report two cases of solitary fibrous tumor affecting the extremities, with 201-thallium scintigraphic and positron emission tomographic appearance. Preoperative magnetic resonance imaging features in both cases were non-specific. Both patients underwent a wide excision. Histologically, case 1 showed spindle cells growing in \\

Tomoaki Fukui; Yoji Kawaguchi; Teruya Kawamoto; Toshiaki Hitora; Tetsuji Yamamoto; Toshihiro Akisue; Yoshio Kushida; Reiji Haba

63

Nasal chondromesenchymal hamartomas arise secondary to germline and somatic mutations of DICER1 in the pleuropulmonary blastoma tumor predisposition disorder.  

PubMed

Nasal chondromesenchymal hamartoma (NCMH) is a rare nasal tumor that typically presents in young children. We previously reported on NCMH occurrence in children with pleuropulmonary blastoma (PPB), a rare pulmonary dysembryonic sarcoma that is the hallmark neoplasm in the PPB-associated DICER1 tumor predisposition disorder. Original pathologic materials from individuals with a PPB, PPB-associated tumor and/or a DICER1 mutation were centrally reviewed by the International PPB Registry. Paraffin-embedded NCMH tumor tissue was available in three cases. Laser-capture microdissection was used to isolate mesenchymal spindle cells and cartilage in one case for Sanger sequencing of DICER1. Nine patients (5F/4M) had PPB and NCMH. NCMH was diagnosed at a median age of 10 years (range 6-21 years). NCMH developed 4.5-13 years after PPB. Presenting NCMH symptoms included chronic sinusitis and nasal congestion. Five patients had bilateral tumors. Local NCMH recurrences required several surgical resections in two patients, but all nine patients were alive at 0-16 years of follow-up. Pathogenic germline DICER1 mutations were found in 6/8 NCMH patients tested. In 2 of the patients with germline DICER1 mutations, somatic DICER1 missense mutations were also identified in their NCMH (E1813D; n = 2). Three additional PPB patients developed other nasal lesions seen in the general population (a Schneiderian papilloma, chronic sinusitis with cysts, and allergic nasal polyps with eosinophils). Two of these patients had germline DICER1 mutations. Pathogenic germline and somatic mutations of DICER1 in NCMH establishes that the genetic etiology of NCMH is similar to PPB, despite the disparate biological potential of these neoplasms. PMID:25118636

Stewart, Douglas R; Messinger, Yoav; Williams, Gretchen M; Yang, Jiandong; Field, Amanda; Schultz, Kris Ann P; Harney, Laura A; Doros, Leslie A; Dehner, Louis P; Hill, D Ashley

2014-11-01

64

Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors  

ClinicalTrials.gov

Childhood Extracranial Germ Cell Tumor; Childhood Extragonadal Germ Cell Tumor; Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Yolk Sac Tumor; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Ovarian Germ Cell Tumor; Testicular Choriocarcinoma; Testicular Choriocarcinoma and Embryonal Carcinoma; Testicular Choriocarcinoma and Yolk Sac Tumor; Testicular Embryonal Carcinoma; Testicular Embryonal Carcinoma and Yolk Sac Tumor; Testicular Yolk Sac Tumor

2014-03-18

65

Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke-L?wenstein tumor): a case report and review of the literature  

PubMed Central

Introduction Verrucous carcinoma of the external genitalia and perianal region is a rare variant of well-differentiated squamous cell carcinoma. It has been reported to have limited metastatic potential. Case presentation We report the case of a 54 year-old Moroccan man who presented with locally advanced giant condyloma acuminatum (Buschke–Löwenstein tumor) after prolonged intervals of neglect (approximately 10 years). The disease covered his suprapubic, external genitalia and perianal region. It was locally aggressive with extensive tissue destruction. After a biopsy of the lesion, the diagnosis of verrucous carcinoma was confirmed. He initially received chemoradiotherapy, followed by extensive local excision, but he developed septic shock and died a few days later. Conclusions The purpose of this case report is to present a case of verrucous carcinoma arising in an extensive giant condyloma acuminatum (Buschke–Löwenstein tumor) and discuss the literature on its diagnosis and management. PMID:24354693

2013-01-01

66

Project ARISE  

NSDL National Science Digital Library

Project ARISE (American Renaissance in Science Education) is an initiative to restructure the high-school science curriculum by changing the order in which courses are traditionally taught--placing physics first, followed by chemistry, then biology (instead of biology-chemistry-physics). This approach to the science curriculum is a collaborative effort that brings teachers and scientists together in the educational process. Site materials include a brief overview of the program and a video presentation on the state of science education in the United States. There are also curriculum materials for each subject: sets of units on biology and physics, and tutorials and lab simulations for chemistry.

Lederman, Leon

2006-02-13

67

Loss of heterozygosity in spontaneous and X-ray-induced intestinal tumors arising in F1 hybrid min mice: evidence for sequential loss of APC(+) and Dpc4 in tumor development.  

PubMed

Min (multiple intestinal neoplasia) mice carry a mutant allele of the murine Apc (adenomatous polyposis coli) locus and are predisposed to intestinal adenoma formation in the intestinal tract. Early studies have shown complete loss of function of Apc by whole chromosome loss on the tumor-sensitive C57BL/6J genetic background and in AKR x B6 F1 hybrids. Gamma-radiation-induced chromosomal losses focus the critical region on wt Apc, but because of the limited number of polymorphic markers used, no other critical regions of loss on chromosome 18 were identified. Using intestinal tumors arising spontaneously and induced by X-rays in CBA/H x C57BL/6J F1 hybrid mice and high-resolution microsatellite loss of heterozygosity (LOH) techniques, we provide mapping data for wt Apc loss, which confirms and extends earlier observations. In addition, high-frequency loss events at the Dpc4 locus were found in both spontaneous and radiation-induced tumors. These data identified LOH of Dpc4 as a critical secondary event following complete functional loss of Apc. LOH across the Trp53 genomic region of chromosome 11 was not observed. No LOH was recorded for the Mom1 candidate gene Pla2g2a or for 9 out of 10 polymorphic markers from the Mom1 genomic region on murine chromosome 4. One marker mapping distal to Pla2g2a showed LOH in a small minority of spontaneous tumors. These data support the contention that Mom1 does not act as a classical tumor suppressor. Overall, our data indicates a significant role for Dpc4 mutation in intestinal tumor progression in the mouse and provides further evidence for the importance of interstitial chromosome losses in radiation tumorigenesis. PMID:10862047

Haines, J; Dunford, R; Moody, J; Ellender, M; Cox, R; Silver, A

2000-08-01

68

The esterification of cholesterol in the yolk sac membrane of the chick embryo  

Microsoft Academic Search

The uptake of lipid from the yolk by the yolk sac membrane of the chick embryo is accompanied by the rapid esterification\\u000a of a large proportion of the yolk cholesterol. This could arise from enhanced acyl-CoA:cholesterol acyltransferase (ACAT)\\u000a activity and\\/or inhibition of cholesteryl ester hydrolase (CEH) activity. The activity of ACAT was therefore measured in microsomes\\u000a obtained from yolk sac

J. H. Shand; D. W. West; R. J. McCartney; R. C. Noble; B. K. Speake

1993-01-01

69

SAC Minutes Friday, April 27, 2012  

E-print Network

SAC Minutes Friday, April 27, 2012 SUB ROOM 266J, 3pm Attendance: Alannah Johnston, Audrey Gardiner. PRESENTATIONS 3. CONSTITUTIONS MOVED ELAINE KUO, SECONDED MO SALEMY: "BE IT RESOLVED THAT SAC constitute the U IT RESOLVED THAT SAC approve the minutes of their meeting held April 16, 2012." ...Carried 5. BOOKINGS MOVED

Pulfrey, David L.

70

SAC Minutes Tuesday, March 13, 2012  

E-print Network

SAC Minutes Tuesday, March 13, 2012 SUB ROOM 266J, 12:30 pm Attendance: Alannah Johnston, Audrey MOVED ELAINE KUO, SECONDED STEWART MCGILLIVRAY: "BE IT RESOLVED THAT SAC constitute Sustainability Club. ...Carried MOVED ELAINE KUO, SECONDED ALANNAH JOHNSTON: "BE IT RESOLVED THAT SAC reconstitute Indigenous

Pulfrey, David L.

71

SAC Minutes Wednesday, Nov 14, 2012  

E-print Network

SAC Minutes Wednesday, Nov 14, 2012 SUB ROOM 266J, 3:00pm Attendance: Adam Melhem, Caroline Wong-13) "BE IT RESOLVED THAT SAC approve the constitution of Sales Club as an AMS club." ...Carried 2. MOVED ADAM MELHEM, SECONDED PHILIP HE: (SACD 73-13) "BE IT RESOLVED THAT SAC approve the constitution

Pulfrey, David L.

72

SAC Minutes Wednesday, Sept 12, 2012  

E-print Network

SAC Minutes Wednesday, Sept 12, 2012 SUB ROOM 266J, 3:00pm Attendance: Adam Melhem, Alishia Adams HANDFIELD: (SACD 44) "BE IT RESOLVED THAT SAC approve the constitution of Free the Children Club as an AMS IT RESOLVED THAT SAC approve the minutes of their meeting held on Aug 30, 2012." ...Carried 5. BOOKINGS MOVED

Pulfrey, David L.

73

SAC Minutes Thursday, May 24, 2012  

E-print Network

SAC Minutes Thursday, May 24, 2012 SUB ROOM 266J, 4pm Attendance: Adam Melhem, Alishia Adams, SECONDED KATHLEEN HANDFIELD: "BE IT RESOLVED THAT SAC constitute International Sustainable Economics IT RESOLVED THAT SAC approve the minutes of their meeting held May 17, 2012." ...Carried 5. BOOKINGS 6. OTHER

Pulfrey, David L.

74

SAC Minutes Wednesday, Jan16, 2013  

E-print Network

SAC Minutes Wednesday, Jan16, 2013 SUB ROOM 266J, 3:00pm Attendance: Adam Melhem, Alishia Adams: "BE IT RESOLVED THAT SAC approve Adam Melhem as chair." ...Carried PRESENTATIONS CONSTITUTIONS MINUTES 2. MOVED BARNABAS , SECONDED KATHLEEN: (SACD 81-13) "BE IT RESOLVED THAT SAC approve the minutes

Pulfrey, David L.

75

SAC Minutes Wednesday, Sept 19, 2012  

E-print Network

SAC Minutes Wednesday, Sept 19, 2012 SUB ROOM 266J, 3:00pm Attendance: Adam Melhem, Alishia Adams SAC member at large � Philip He 2. PRESENTATIONS � Guitar Club 3. CONSTITUTIONS 4. MINUTES MOVED ADAM MELHEM, SECONDED KATHLEEN HANDFIELD: (SACD 043-13) "BE IT RESOLVED THAT SAC approve the minutes

Pulfrey, David L.

76

SAC Minutes Thursday, May 31, 2012  

E-print Network

SAC Minutes Thursday, May 31, 2012 SUB ROOM 266J, 4pm Attendance: Adam Melhem, Alishia Adams: "BE IT RESOLVED THAT SAC constitute International Sustainable Economics Initiative as an AMS club." ...Defeated MOVED ADAM MELHEM, SECONDED ELAINE KUO: "BE IT RESOLVED THAT SAC constitute Undergraduate Network

Pulfrey, David L.

77

SAC Minutes Monday, April 16, 2012  

E-print Network

SAC Minutes Monday, April 16, 2012 SUB ROOM 266J, 1pm Attendance: Alannah Johnston, Elaine Kuo Enterprise club 3. CONSTITUTIONS MOVED ELAINE KUO, SECONDED STEWART MCGILLIVRAY: "BE IT RESOLVED THAT SAC STEWART MCGILLIVRAY: "BE IT RESOLVED THAT SAC approve the minutes of their meeting held March 27, 2012

Pulfrey, David L.

78

SAC Minutes Thursday, Aug 9, 2012  

E-print Network

SAC Minutes Thursday, Aug 9, 2012 SUB ROOM 266J, 4:00pm Attendance: Alishia Adams, Elaine Kuo. 1. INTRODUCTIONS MOVED KATHLEEN HANDFIELD, SECONDED ELAINE KUO: "BE IT RESOLVED THAT SAC approve. CONSTITUTIONS MOVED KATHLEEN HANDFIELD, SECONDED ELAINE KUO: "BE IT RESOLVED THAT SAC approve the constitution

Pulfrey, David L.

79

SAC Minutes Thursday, July 12, 2012  

E-print Network

SAC Minutes Thursday, July 12, 2012 SUB ROOM 266J, 4pm Attendance: Adam Melhem, Alishia Adams. CONSTITUTIONS MOVED KATHLEEN HANDFIELD, SECONDED NICOLA SIMPSON: "BE IT RESOLVED THAT SAC approve the constitution of Thaqalayn Muslim Association as an AMS club." ...Tabled *SAC Vice Chair, Adam, will contact

Pulfrey, David L.

80

SAC Minutes Tuesday, January 31, 2012  

E-print Network

SAC Minutes Tuesday, January 31, 2012 SUB ROOM 266J, 12:30 pm Attendance: Alannah Johnston WARWICK: "BE IT RESOLVED THAT SAC constitute Cooking Club as an AMS club." ...Carried MOVED ALANNAH JOHNSTON, SECONDED ELAINE KUO: "BE IT RESOLVED THAT SAC re-constitute Go Club as an AMS club." ...Carried

Pulfrey, David L.

81

SAC Minutes Wednesday, Oct 3, 2012  

E-print Network

SAC Minutes Wednesday, Oct 3, 2012 SUB ROOM 266J, 3:00pm Attendance: Adam Melhem, Alishia Adam-13) "BE IT RESOLVED THAT SAC approve the constitution of The Moustache Society as an AMS Club." ...Carried MINUTES 2. MOVED ADAM MELHEM, SECONDED KATHLEEN HANDFIELD: (SACD 50-13) "BE IT RESOLVED THAT SAC approve

Pulfrey, David L.

82

SAC Minutes Wednesday, Oct 10, 2012  

E-print Network

SAC Minutes Wednesday, Oct 10, 2012 SUB ROOM 266J, 3:00pm Attendance: Adam Melhem, Alishia Adam PRESENTATIONS CONSTITUTIONS 1. MOVED ADAM MELHEM, SECONDED PHILIP HE: (SACD 53-13) "BE IT RESOLVED THAT SAC, SECONDED CLARKE MCCORKELL: (SACD 54-13) "BE IT RESOLVED THAT SAC approve the constitution of The Spark Club

Pulfrey, David L.

83

How to Improve the SAC Jennifer Seberry  

E-print Network

How to Improve the SAC Jennifer Seberry Xian-Mo Zhang Yuliang Zheng The Centre for Computer effective method for transforming Boolean functions that do not satisfy the strict avalanche criterion (SAC algorithms. Key Words cryptography, security in digital systems, strict avalanche criterion (SAC), substitu

Seberry, Jennifer

84

SAC Minutes Wednesday, Jan 23, 2013  

E-print Network

SAC Minutes Wednesday, Jan 23, 2013 SUB ROOM 266J, 3:00pm Attendance: Adam Melhem, Alishia Adams: "BE IT RESOLVED THAT SAC approve Adam Melhem as chair." ...Carried PRESENTATIONS Presentation PHILIP HE: (SACD 82-13) "BE IT RESOLVED THAT SAC approve the minutes of their meeting held on Jan 16

Pulfrey, David L.

85

SAC Minutes Thursday, May 4, 2012  

E-print Network

SAC Minutes Thursday, May 4, 2012 SUB ROOM 266J, 4pm Attendance: Adam Melhem, Alishia Adams, Elaine. CONSTITUTIONS 4. MINUTES MOVED CLARKE, SECONDED ELAINE: "BE IT RESOLVED THAT SAC approve the minutes IT RESOLVED THAT SAC approve of Alumni members to be honorary members." ...Carried VOC · wants alumni members

Pulfrey, David L.

86

SAC Minutes Tuesday, February 28, 2012  

E-print Network

SAC Minutes Tuesday, February 28, 2012 SUB ROOM 266J, 12:30 pm Attendance: Alannah Johnston University Bangla Club 3. CONSTITUTIONS MOVED AUDREY GARDINER, SECONDED ELAINE KUO: "BE IT RESOLVED THAT SAC: "BE IT RESOLVED THAT SAC constitute The Combined Major in Sciences Students Association as an AMS club

Pulfrey, David L.

87

SAC Minutes Wednesday, Oct 24, 2012  

E-print Network

SAC Minutes Wednesday, Oct 24, 2012 SUB ROOM 266J, 3:00pm Attendance: Adam Melhem, Alishia Adam. MOVED KATHLEEN HANDFIELD, SECONDED NICOLA SIMPSON: (SACD 57-13) "BE IT RESOLVED THAT SAC approve KATHLEEN HANDFIELD, SECONDED PHILIP HE: (SACD 58-13) "BE IT RESOLVED THAT SAC approve the constitution

Pulfrey, David L.

88

Pembrokeshire marine SAC grey seal monitoring 2005.  

E-print Network

Pembrokeshire marine SAC grey seal monitoring 2005. Strong P.G., Lerwill, J., Morris, S Nominated officer(s): T. Stringell, B. Bullimore Title: Pembrokeshire marine SAC grey seal monitoring 2005.R. & Stringell, T.B. (2006). Pembrokeshire marine SAC grey seal monitoring 2005. CCW Marine Monitoring Report No

Bearhop, Stuart

89

SAC Minutes Thursday, January 12, 2012  

E-print Network

SAC Minutes Thursday, January 12, 2012 SUB ROOM 266J, 5:00 pm Attendance: Elaine Kuo, Audrey THAT SAC constitute The Armenian Students Association as an AMS club." ...Carried 4. MINUTES: MOVED KYLE WARWICK, SECONDED ELAINE KUO: "BE IT RESOLVED THAT SAC approve the minutes of their meeting held Dec 1

Pulfrey, David L.

90

SAC Minutes Tuesday, February 14, 2012  

E-print Network

SAC Minutes Tuesday, February 14, 2012 SUB ROOM 266J, 12:30 pm Attendance: Alannah Johnston, Elaine THAT SAC constitute The UBC AISES as an AMS club." ...Carried MOVED NONE, SECONDED NONE: "BE IT RESOLVED THAT SAC constitute Association of Canada-China Academic Exchange (ACCAE) as an AMS club." ...Defeated

Pulfrey, David L.

91

SAC Minutes Wednesday, Jan 9, 2013  

E-print Network

SAC Minutes Wednesday, Jan 9, 2013 SUB ROOM 266J, 3:00pm Attendance: Adam Melhem, Alishia Adams. MOVED KATHLEEN HANDFIELD, SECONDED ELAINE KUO: (SACD 79-13) "BE IT RESOLVED THAT SAC approve. 2. MOVED ELAINE KUO, SECONDED CLARKE MCCORKELL: (SACD 80-13) "BE IT RESOLVED THAT SAC approve

Pulfrey, David L.

92

SCIENCE WRITERS' GUIDE Aquarius/SAC-D  

E-print Network

SCIENCE WRITERS' GUIDE Aquarius/SAC-D June 2011 National Aeronautics and Space Administration Studying Earth's Salty Seas from Space #12;Aquarius/SAC-D SCIENCE WRITERS' GUIDE CONTACT INFORMATION Rosemary Sullivant Kevin Miller WRITERS DESIGN #12;Aquarius/SAC-D SCIENCE WRITERS' GUIDE TABLE OF CONTENTS

Waliser, Duane E.

93

SAC Minutes Thursday, June 7, 2012  

E-print Network

SAC Minutes Thursday, June 7, 2012 SUB ROOM 224, 4pm Attendance: Adam Melhem, Alishia Adams, Elaine MOVED ADAM MELHEM, SECONDED KATHLEEN HANDFIELD: "BE IT RESOLVED THAT SAC approve the minutes. DISCUSSION: Commercial Booking Issue MOVED ADAM MELHEM, SECONDED ELAINE KUO: "BE IT RESOLVED THAT SAC

Pulfrey, David L.

94

SAC Minutes Wednesday, Nov 7, 2012  

E-print Network

SAC Minutes Wednesday, Nov 7, 2012 SUB ROOM 266J, 3:00pm Attendance: Adam Melhem, Alishia Adam CONSTITUTIONS 1. MOVED KATHLEEN HANDFIELD, SECONDED ELAINE KUO: "BE IT RESOLVED THAT SAC approve HE: "BE IT RESOLVED THAT SAC approve the minutes of their meeting held on Oct 31, 2012." ...Carried

Pulfrey, David L.

95

SAC Minutes Wednesday, Sept 26, 2012  

E-print Network

SAC Minutes Wednesday, Sept 26, 2012 SUB ROOM 266J, 3:00pm Attendance: Alishia Adam, Caroline Wong-13) "BE IT RESOLVED THAT SAC approve the minutes of their meeting held on Sept 19, 2012." ...Carried BOOKINGS 2. MOVED KATHLEEN HANDFILED, SECONDED BARNABAS CARO: "BE IT RESOLVED THAT SAC approve the booking

Pulfrey, David L.

96

SAC Minutes Tuesday, March 27, 2012  

E-print Network

SAC Minutes Tuesday, March 27, 2012 SUB ROOM 266J, 12:30 pm Attendance: Alannah Johnston, Audrey THAT SAC approve the minutes of their meeting held March 20, 2012." ...Carried 5. BOOKINGS The chair THAT SAC approve the booking of Council Chamber on Friday, March 30, 2012 from 11:30am-5pm. The Ubyssey

Pulfrey, David L.

97

Germ-cell tumors of the mediastinum.  

PubMed

Mediastinal germ-cell tumors (GCTs) usually occur within the anterior mediastinum, accounting for about 15% of all mediastinal cysts and tumors. They are associated with the thymus, presumably arising from extragonadal germ cells or thymic cells with germ-cell potential. Mediastinal seminoma develops primarily in young males with rare cases reported in females; likewise, embryonal carcinoma, endodermal sinus tumor or yolk-sac tumor, choriocarcinoma, and malignant mixed or combined GCTs also overwhelmingly affect males. Mature cystic teratoma affects males and females equally. The prognosis for mediastinal mature cystic teratoma and seminoma is very good. Nonseminomatous malignant GCTs of the mediastinum often present with advanced disease and do not respond as well to chemotherapy as their gonadal counterparts. Nonetheless, it is important to separate mediastinal GCTs from other undifferentiated malignant tumors, especially thymic carcinoma, which has a poor prognosis. Clearly, some patients with mediastinal GCTs respond very well to modern therapies. PMID:10355653

Weidner, N

1999-02-01

98

Performance Analysis of Wavelength Multiplexed Sac Ocdma Codes in Beat Noise Mitigation in Sac Ocdma Systems  

NASA Astrophysics Data System (ADS)

In this paper we investigate the use of wavelength multiplexed spectral amplitude coding (WM SAC) codes in beat noise mitigation in coherent source SAC OCDMA systems. A WM SAC code is a low weight SAC code, where the whole code structure is repeated diagonally (once or more) in the wavelength domain to achieve the same cardinality as a higher weight SAC code. Results show that for highly populated networks, the WM SAC codes provide better performance than SAC codes. However, for small number of active users the situation is reversed. Apart from their promising improvement in performance, these codes are more flexible and impose less complexity on the system design than their SAC counterparts.

Alhassan, A. M.; Badruddin, N.; Saad, N. M.; Aljunid, S. A.

2013-07-01

99

Nasal chondromesenchymal hamartomas arise secondary to germline and somatic mutations of DICER1 in the pleuropulmonary blastoma tumor-predisposition disorder  

PubMed Central

Background Nasal chondromesenchymal hamartoma (NCMH) is a rare nasal tumor that typically presents in young children. We previously reported on NCMH occurrence in children with pleuropulmonary blastoma (PPB), a rare pulmonary dysembryonic sarcoma that is the hallmark neoplasm in the PPB-associated DICER1 tumor predisposition disorder. Methods Original pathologic materials from individuals with a PPB, PPB-associated tumor and/or a DICER1 mutation were centrally reviewed by the International PPB Registry. Paraffin-embedded NCMH tumor tissue was available in three cases. Laser-capture microdissection was used to isolate mesenchymal spindle cells and cartilage in one case for Sanger sequencing of DICER1. Results Nine patients (5F/4M) had PPB and NCMH. NCMH was diagnosed at a median age of 10 years (range 6-21years). NCMH developed 4.5 - 13 years after PPB. Presenting NCMH symptoms included chronic sinusitis and nasal congestion. Five patients had bilateral tumors. Local NCMH recurrences required several surgical resections in two patients, but all nine patients were alive at 0 – 16 years of follow-up. Pathogenic germline DICER1 mutations were found in 6/8 NCMH patients tested. In 2 of the patients with germline DICER1 mutations, somatic DICER1 missense mutations were also identified in their NCMH (E1813D; n=2). Three additional PPB patients developed other nasal lesions seen in the general population (a Schneiderian papilloma, chronic sinusitis with cysts, and allergic nasal polyps with eosinophils). Two of these patients had germline DICER1 mutations. Conclusion Pathogenic germline and somatic mutations of DICER1 in NCMH establishes that the genetic etiology of NCMH is similar to PPB, despite the disparate biological potential of these neoplasms. PMID:25118636

Stewart, Douglas R.; Messinger, Yoav; Williams, Gretchen M.; Yang, Jiandong; Field, Amanda; Schultz, Kris Ann P.; Harney, Laura A.; Doros, Leslie A.; Dehner, Louis P.; Hill, D. Ashley

2014-01-01

100

UNIVERSITY SECRETARIAT How to Appeal to SAC  

E-print Network

1 UNIVERSITY SECRETARIAT STUDENT APPEALS How to Appeal to SAC #12;2 ACADEMIC APPEALS INFORMATION Committee; · what information you need to provide in your appeal; · how the appeal process works; and · how their decision for the faculties if there are no grounds to do so. SAC will review Faculty decisions in only two

101

SAC Minutes Wednesday, Oct 17, 2012  

E-print Network

IT RESOLVED THAT SAC approve the booking of the Norm Theatre on Nov 27 from 6pm to midnight by Knitting and Sewing Club. This is for a movie screening." ...Carried 7. MOVED ADAM MELHEM, SECONDED NICOLA SIMPSON: "BE IT RESOLVED THAT SAC approve the booking of the Norm Theatre on Nov 20 from 5-11pm by the Art

Pulfrey, David L.

102

SAC Headquarters Underground Command Center Cutaway Axonometric Offutt ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SAC Headquarters Underground Command Center - Cutaway Axonometric - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

103

70. SAC command post construction, building 500, undated Offutt ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

70. SAC command post construction, building 500, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

104

59. SAC Plaque, front lawn, building 500, looking east ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

59. SAC Plaque, front lawn, building 500, looking east - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

105

Sisters of the sinuses: cetacean air sacs.  

PubMed

This overview assesses some distinguishing features of the cetacean (whale, dolphin, porpoise) air sac system that may relate to the anatomy and function of the paranasal sinuses in terrestrial mammals. The cetacean respiratory tract has been modified through evolution to accommodate living in water. Lack of paranasal sinuses in modern cetaceans may be a diving adaptation. Bone-enclosed air chambers are detrimental, as their rigid walls may fracture during descent/ascent due to contracting/re-expanding air volumes. Flexible-walled "sinuses" (extracranial diverticula) are a logical adaptation to diving. Odontocetes (toothed whales) exhibit several pairs of paranasal air sacs. Although fossil evidence indicates that paranasal sinuses occur in archaeocetes (ancestors/relatives of living cetaceans), it is not known whether the paranasal sacs derive from these sinuses. Sac pigmentation indicates that they derived from invaginations of the integument. Unlike sinuses, paranasal sacs are not circumferentially enclosed in bone, and therefore can accommodate air volume changes that accompany diving pressure changes. Paired pterygoid sacs, located ventrally along the cetacean skull, connect the pharynx and middle ear cavities. Mysticetes (baleen whales) have a large midline laryngeal sac. Although cetacean air sacs do not appear to be homologous to paranasal sinuses, they may serve some analogous respiratory, vocal, or structural functions. For example, these sacs may participate in gas exchange, thermoregulation, resonance, and skeletal pneumatization. In addition, they may subserve unique aquatic functions, such as increasing inspiratory volume, mitigating pressure-induced volume change, air shunting to reduce respiratory dead space, and facilitating underwater sound production and transmission. PMID:18951477

Reidenberg, Joy S; Laitman, Jeffrey T

2008-11-01

106

Glycosaminoglycan-sac formation in vitro. Interactions between normal and malignant cells.  

PubMed

The interaction of monolayer normal human or normal rat cells with suspension Walker rat tumor cells was demonstrated cytologically, during a cocultivation period of thirty days. At ten days, Walker rat tumor cells were interiorized in the cytoplasm of the normal monolayer host cells. At twenty days, degeneration of the interiorized tumor cells followed by mucification led to glycosaminoglycan-sac formation. At thirty days, tumor nodules and protease (alpha 1-chymotrypsin)- bound glycosaminoglycan(s) extracellular matrix, transversing the culture in membranous rivulets, were formed. The overall interaction resulted in the death of the interiorized tumour cell and survival of the normal host cells containing a glycosaminoglycan-sac. The use of bladder tumor cell imprints showed that cell interiorization, degeneration and extracellular matrix formation identical to that of the co-cultures, also occur in vivo. Cell interiorization within malignant cell cultures led to syncytia formation and survival of both host and interiorized cells. Identical glycosaminoglycan extracellular matrix to that of the co-cultures and syncytia was also observed in smears of EBV-producing (P3HR-1) cell cultures. The observations are discussed in terms of invasion, emperipolesis, cannibalism, phagocytosis and extracellular matrix. It is concluded that a glycosaminoglycan-sac is produced by the interiorization of a tumor cell into a normal cell while interiorization of a tumor cell into another tumor cell resulted in syncytia formation. PMID:8075481

Logothetou-Rella, H

1994-04-01

107

Characterization of the divergent sacBK and sacAR operons, involved in sucrose utilization by Lactococcus lactis.  

PubMed

The divergently transcribed sacBK and sacAR operons, which are involved in the utilization of sucrose by Lactococcus lactis NZ9800, were examined by transcriptional and gene inactivation studies. Northern analyses of RNA isolated from cells grown at the expense of different carbon sources revealed three sucrose-inducible transcripts: one of 3.2 kb containing sacB and sacK, a second of 3.4 kb containing sacA and sacR, and a third of 1.8 kb containing only sacR. The inactivation of the sacR gene by replacement recombination resulted in the constitutive transcription of the sacBK and sacAR operons in the presence of different carbon sources, indicating that SacR acts as a repressor of transcription. PMID:10074089

Luesink, E J; Marugg, J D; Kuipers, O P; de Vos, W M

1999-03-01

108

DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings  

ClinicalTrials.gov

Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Mixed Germ Cell Tumor; Ovarian Teratoma; Ovarian Yolk Sac Tumor; Testicular Choriocarcinoma; Testicular Embryonal Carcinoma; Testicular Seminoma; Testicular Teratoma; Testicular Yolk Sac Tumor

2014-02-17

109

Final Report to: -English Nature (UK Marine SACs Project)  

E-print Network

Final Report to: - English Nature (UK Marine SACs Project) An evaluation of approaches Sites in the UK. English Nature (UK Marine SACs Project). ISBN 1 85716 584 5 1 #12;UK Marine SACs of a project, commissioned as part of the UK Marine SACs Project, to evaluate different approaches employed

Jones, Peter JS

110

Agrgation de sac-de-sacs-de-mots pour la recherche d'information par modles vectoriels  

E-print Network

Agr�gation de sac-de-sacs-de-mots pour la recherche d'information par mod�les vectoriels Vincent �tudie l'int�r�t de repr�senter les documents textuels non plus comme des sacs-de-mots, mais comme des sacs-de-sacs-de-mots. Au coeur de l'utilisation de cette repr�sentation, le calcul de similarit� entre

Paris-Sud XI, Université de

111

Characterization of multiple promoters and transcript stability in the sacB-sacC gene cluster in Zymomonas mobilis.  

PubMed

In Zymomonas mobilis, the extracellular levansucrase (SacB) and extracellular sucrase (SacC) are involved in sucrose hydrolysis. Genes coding for these two enzymes (sacB and sacC) are arranged in a cluster in the genome and separated by a short intervening sequence. The level of sacC transcript was 12-fold higher than that of sacB transcript. On the other hand, transcript stability analysis in sucrose grown cultures revealed that the half-life of the sacB transcripts (153 s) was more than twofold higher than that of sacC transcript (66 s). The decay curves of sacB and sacC transcripts analyzed by the semi-quantitative RT-PCR correlated well with the decay curves of the respective enzyme activities. In the sacB promoter disruption mutant, Z. moblis BT2, the extracellular sucrase activity decreased from 2.6 to 2.0 U mg(-1) in sucrose medium due to the loss of SacB expression. The expression of sacC in the absence of the sacB promoter suggested that these two genes could be transcribed as different mRNAs. The promoter-lacZ fusion studies in Escherichia coli proved that the short intervening region acts as a strong promoter for the sacC gene. PMID:19415238

Senthilkumar, V; Rajendhran, J; Busby, S J W; Gunasekaran, P

2009-06-01

112

Brain tumor (image)  

MedlinePLUS

Brain tumors are classified depending on the exact site of the tumor, the type of tissue involved, benign ... tendencies of the tumor, and other factors. Primary brain tumors can arise from the brain cells, the meninges ( ...

113

SAC-B, Argentine scientific satellite  

NASA Technical Reports Server (NTRS)

The project and the missions of the Argentine scientific satellite, SAC-B, are summarized. SAC-B is an international cooperative project between NASA and the Secretariat of State of Science and Technology of the Argentine Republic. The objective of SAC-B is to advance the study of solar physics and astrophysics through the examination of solar flares, gamma ray burst sources and the diffuse soft X-ray cosmic background. The scientific payload comprises an instrument to measure the temporal evolution of X-ray emissions from solar flares as well as nonsolar gamma ray bursts, a combined soft X-ray and gamma ray burst detector, a diffuse X-ray background detector, and an energetic neutral atoms detector.

Gulich, J. M.; White, C.

1994-01-01

114

Müllerian adenosarcoma arising from rectal endometriosis.  

PubMed

A Müllerian adenosarcoma is an extremely rare tumor characterized by a stromal component of usually low-grade malignancy and by a benign glandular epithelial component. A Müllerian adenosarcoma occurs mainly in the uterus, but also in extrauterine locations. Extrauterine Müllerian adenosarcomas are thought to arise from endometriotic deposits. A 36-year-old female presented to Daegu Catholic University Medical Center with a symptom of loose stool for several months. The imaging studies revealed a rectal mass, so she underwent a laparoscopic low anterior resection. Although extemporary pathology revealed an inflammatory myofibroblastic tumor, the final histologic diagnosis was a Müllerian adenosarcoma arising from rectal endometriosis. To our knowledge, except a concomitant rectal villotubular adenoma, cases of Müllerian adenosarcomas arising the rectal wall are rare. An adenosarcoma arising from endometriosis should be considered in the differential diagnosis of a pelvic mass, even one appearing in rectal wall, because ectopic endometrial tissue exists everywhere. PMID:25360431

Yang, Chunseok; Oh, Hoon Kyu; Kim, Daedong

2014-10-01

115

Lacrimal sac plugging caused by Aspergillus fumigatus.  

PubMed

Aspergillus fumigatus is a rare cause of canalicular obstruction. We present a case where an aspergillosis plug caused extreme tenderness, epiphoria and discharge from the lacrimal puntum. CT scan showed dilation of the lacrimal sac. Medical treatment did not relieve the symptoms. During a planned DCR the sac was opened before the osteotomy, and found to contain a plug which caused the obstruction. Aspergillus fumigatus was grown from culture. The DCR was abandoned and the patient is symptom free one year after the procedure. PMID:9591962

Kristinsson, J K; Sigurdsson, H

1998-04-01

116

Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors  

ClinicalTrials.gov

Childhood Embryonal Tumor; Childhood Extracranial Germ Cell Tumor; Childhood Extragonadal Germ Cell Tumor; Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Childhood Teratoma; Ovarian Embryonal Carcinoma; Ovarian Yolk Sac Tumor; Stage II Malignant Testicular Germ Cell Tumor; Stage IIA Ovarian Germ Cell Tumor; Stage IIB Ovarian Germ Cell Tumor; Stage IIC Ovarian Germ Cell Tumor; Stage III Malignant Testicular Germ Cell Tumor; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIC Ovarian Germ Cell Tumor; Testicular Choriocarcinoma and Yolk Sac Tumor; Testicular Embryonal Carcinoma

2014-02-28

117

Adult alveolar rhabdomyosarcoma of the lacrimal sac.  

PubMed

Abstract Lacrimal sac tumours are rare, but must be considered in the diagnosis of patients presenting with masses in the medial canthal region. We report a single case of lacrimal sac rhabdomyosarcoma in a 31-year-old man. The patient self-presented to the eye department with a 4-week history of discomfort, epiphora and a medial canthal mass. After no response to 1 week of oral antibiotics for a presumed diagnosis of dacryocystitis and the presence of firm mass extending above the medial canthal tendon, surgical exploration was carried out which revealed a lacrimal sac mass. Histologically this showed an alveolar rhabdomyosarcoma, which was confirmed on immunohistochemistry. After 4 rounds of chemotherapy and 50.4Gy of radical radiotherapy, the patient is well with no signs of further local or distant disease at 11-months follow-up and 20 months following initial diagnosis. To our knowledge, there are no previously reported adult cases of lacrimal sac alveolar rhabdomyosarcoma in the peer-reviewed literature. We want to highlight the unique diagnosis in this case as well as drawing attention to the possibility of malignancy in patients responding poorly to management when an initial diagnosis of dacryocystitis is made in the presence of a medial canthal mass. PMID:25207922

Neffendorf, James E; Bagdonaite, Laura; Mudhar, Hardeep S; Pearson, Andrew R

2014-12-01

118

Comparing and Contrasting NAEYC and SACS Accreditation  

ERIC Educational Resources Information Center

The purpose of this paper is to describe, compare, and contrast an early childhood departmental accreditation process from the National Association for the Education of Young Children (NAEYC) and a college/university-wide accreditation process from the Southern Association of Colleges and Schools (SACS). The history of higher education…

Isaacs, Mary Ruth

2010-01-01

119

SAC Minutes Thursday, Aug 2, 2012  

E-print Network

healthcare system and provide lectures, discussions, projects, and case studies for students to improve the system. MOVED KATHLEEN HANDFIELD, SECONDED JENNY CHEN: "BE IT RESOLVED THAT SAC approve the constitution of Fashion Club as an AMS Club." ...Carried Host fashion shows and private shopping events Connect students

Pulfrey, David L.

120

SAC Minutes Tuesday, January 24, 2012  

E-print Network

Club Yoga Club 3. CONSTITUTIONS MOVED MARIA CIRSTEA, SECONDED TRISTAN MILLER: "BE IT RESOLVED THAT SAC constitute Curling Club as an AMS club." ...Carried 4. MINUTES: MOVED MARIA CIRSTEA, SECONDED KYLE WARWICK 17- 20, 2012 by the Law Revue". The UBC Law Revue wants to host their annual skits night in the NORM

Pulfrey, David L.

121

SAC Minutes Thursday, July 26, 2012  

E-print Network

. INTRODUCTIONS The chair was passed to Adam Melhem at 4:31pm. 2. PRESENTATIONS The Knitting and Sewing Club CLARKE MCCORKELL: "BE IT RESOLVED THAT SAC approve the constitution of Knitting and Sewing Club as an AMS club." *started as social knitting group in Totem last year. ...Carried MOVED ADAM MELHEM, SECONDED

Pulfrey, David L.

122

SAC Tax Help Prepared Feb. 2010  

E-print Network

1 SAC Tax Help Prepared Feb. 2010 Disclaimer: We are not tax experts, and cannot be held responsible for your tax forms. (neither can DBBS, WashU, etc...) 1 Taxes for international students Go to http://oisshome.wustl.edu/taxes/FilingTaxes.html for tax information from the Office for International

Doering, Tamara

123

SAC Minutes Thursday, Aug 23, 2012  

E-print Network

IT RESOLVED THAT SAC approve the booking by Sororities of UBC on Monday, Nov 26, 2012 from 5pm-10pm. Sororities of UBC wants to book the Norm to host a student film festival. All proceeds will go to charity

Pulfrey, David L.

124

46. SAC Commander in Chief entry, second floor, Awing, building ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. SAC Commander in Chief entry, second floor, A-wing, building 500, looking north - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

125

77. SAC control center administrative section basement floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

77. SAC control center administrative section basement floor plan, drawing number not listed, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

126

43. Main entry to SAC Control offices, second floor, Awing, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. Main entry to SAC Control offices, second floor, A-wing, building 500, looking southeast - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

127

65. SAC Minuteman Missile "shell", mounted for permanent display in ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

65. SAC Minuteman Missile "shell", mounted for permanent display in front lawn, building 500, looking east - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

128

71. SAC command post construction, building 500, January 20, 1987 ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

71. SAC command post construction, building 500, January 20, 1987 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

129

49. SAC Chief of Staff office, second floor, Awing, building ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

49. SAC Chief of Staff office, second floor, A-wing, building 500, looking northwest - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

130

3. Threequarter view of building 500 looking southeast from SAC ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Three-quarter view of building 500 looking southeast from SAC Boulevard - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

131

61. SAC control center command post construction, March 2, 1956, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

61. SAC control center command post construction, March 2, 1956, looking northeast - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

132

8. SAC command center underground structure, building 501, basement entry, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. SAC command center underground structure, building 501, basement entry, machine room, April 11, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

133

10. SAC command center, main operations area, underground structure, building ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. SAC command center, main operations area, underground structure, building 501, circa 1980 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

134

80. SAC control center administration section third floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

80. SAC control center administration section third floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

135

Servei d'Activitats Culturals Normativa interna del SAC  

E-print Network

Servei d'Activitats Culturals Normativa interna del SAC Formaci� 1. Lloc, dates i horaris Els� altres criteris, si ho considera oport�. 5. Anul�laci� d'un curs El SAC es reserva la possibilitat de

Oro, Daniel

136

64. SAC command post lobby, building 500, November 8, 1956, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

64. SAC command post lobby, building 500, November 8, 1956, looking east - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

137

78. SAC control center aboveground addition partial first floor plan, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

78. SAC control center aboveground addition partial first floor plan, drawing number AW30-02-09, dated 15 October, 1962 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

138

47. SAC Commander in Chief office, second floor, Awing, building ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

47. SAC Commander in Chief office, second floor, A-wing, building 500, looking northwest - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

139

48. SAC Deputy Commander in Chief office, second floor, Awing, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

48. SAC Deputy Commander in Chief office, second floor, A-wing, building 500, looking southeast - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

140

67. Aerial view of SAC command post, building 500, looking ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

67. Aerial view of SAC command post, building 500, looking northeast, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

141

62. Aerial view of SAC command post, building 500, looking ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

62. Aerial view of SAC command post, building 500, looking east - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

142

12. SAC command center, main operations area, underground structure, building ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. SAC command center, main operations area, underground structure, building 501, circa 1960 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

143

63. Aerial view of SAC command post construction, looking west ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

63. Aerial view of SAC command post construction, looking west - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

144

69. Vice President Ford entering SAC command post, February, 1974 ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

69. Vice President Ford entering SAC command post, February, 1974 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

145

66. SAC command post lobby, building 500, undated, looking southeast ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

66. SAC command post lobby, building 500, undated, looking southeast - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

146

68. Aerial view of SAC command post, building 500, looking ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

68. Aerial view of SAC command post, building 500, looking northeast, spring, 1957 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

147

11. SAC command center, main operations area, underground structure, building ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. SAC command center, main operations area, underground structure, building 501, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

148

4. Sac shield at entry of command center, building 501, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Sac shield at entry of command center, building 501, looking west - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

149

9. SAC command center, main operations area, underground structure, building ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. SAC command center, main operations area, underground structure, building 501, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

150

60. SAC emblem on side of missile, front lawn, building ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

60. SAC emblem on side of missile, front lawn, building 500, looking west - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

151

79. SAC control center administration section first floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

79. SAC control center administration section first floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

152

72. SAC control center underground structure lower floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

72. SAC control center underground structure lower floor plan, drawing number 32-02-03, dated 1 February 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

153

75. SAC control center underground structure middle floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

75. SAC control center underground structure middle floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

154

76. SAC control center underground structure upper floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

76. SAC control center underground structure upper floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

155

13. SAC command center, weather center, underground structure, building 501, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. SAC command center, weather center, underground structure, building 501, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

156

LCLS Scientific Advisory Committee (SAC) 2013 Term until year end  

E-print Network

LCLS Scientific Advisory Committee (SAC) 2013 Term until year end: 2013 Rafael Abela PSI rafael.bressler@xfel.eu Thomas Russell (PRP Chair) University of Massachussetts russell@mail.pse.umass.edu Linda Young (ex-SAC Scientific Advisory Committee (SAC) is to advise the LCLS Director on issues relating to the management

Wechsler, Risa H.

157

SAC Minutes April 23, 2014 TO: Simplified Acquisition Committee  

E-print Network

SAC Minutes � April 23, 2014 1 TO: Simplified Acquisition Committee FROM: Director, Division of Simplified Acquisition Policy and Services Office of Acquisition and Logistics Management SUBJECT: SAC Meeting Minutes � April 23, 2014 SAC Members & Alternate Members present: Delegated Office of Acquisition

Rau, Don C.

158

13th ISTC SAC Seminar Global Design Effort 1  

E-print Network

2-Sept-10 13th ISTC SAC Seminar Global Design Effort 1 Barry Barish Novosibirsk 2-Sept-10 ILC R&D & Global Design Effort #12;2-Sept-10 13th ISTC SAC Seminar Global Design Effort 22 Why a Linear Collider Reference Design and Cost? · Present program and plans #12;2-Sept-10 13th ISTC SAC Seminar Global Design

159

SAC Minutes March 26, 2014 TO: Simplified Acquisition Committee  

E-print Network

SAC Minutes � March 26, 2014 1 TO: Simplified Acquisition Committee FROM: Director, Division of Simplified Acquisition Policy and Services Office of Acquisition and Logistics Management SUBJECT: SAC Meeting Minutes � March 26, 2014 SAC Members & Alternate Members present: Delegated Office of Acquisition

Rau, Don C.

160

SAC Minutes January 30, 2014 TO: Simplified Acquisition Committee  

E-print Network

SAC Minutes � January 30, 2014 1 TO: Simplified Acquisition Committee FROM: Director, Division of Simplified Acquisition Policy and Services Office of Acquisition and Logistics Management SUBJECT: SAC Meeting Minutes � January 30, 2014 SAC Members & Alternate Members present: Delegated Office

Rau, Don C.

161

First Announcement 6th Aquarius/SAC-D Science Meeting  

E-print Network

First Announcement 6th Aquarius/SAC-D Science Meeting 19-21 July 2010 Seattle, Washington, USA Theme: Science Preparations for Launch The Aquarius/SAC-D satellite mission will convene the 6th Science Meeting in Seattle, WA, USA, 19-21 July 2010. Aquarius/SAC-D science objectives address ocean circulation

Waliser, Duane E.

162

Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors  

ClinicalTrials.gov

Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Unspecified Childhood Solid Tumor, Protocol Specific

2013-05-01

163

Aquarius/SAC-D Educational Wall Poster  

NSDL National Science Digital Library

This is a poster about the Aquarius/SAC-D satellite mission, with an image depicting the satellite in orbit. The back of the poster describes the mission's scientific goals and benefits, including the scientific value of maps of sea surface salinity. The Hands On Activities & Online Data Tools panel gives an overview of the classroom lessons and tools that are available on the mission website.

164

Aquarius/SAC-D Mission Overview  

NASA Technical Reports Server (NTRS)

Aquarius/SAC-D is a cooperative international mission developed between the National Aeronautics and Space Administration (NASA) of United States of America (USA) and the Comision Nacional de Actividades Espaciales (CONAE) of Argentina. The overall mission objective is to contribute to the understanding of the total Earth system and the consequences of the natural and man-made changes in the environment of the planet. Major themes are: ocean surface salinity, water cycle, climate, natural hazards and cryosphere.

Sen, Amit; Kim, Yunjin; Caruso, Daniel; Lagerloef, Gary; Colomb, Raul; Yueh, Simon; LeVine, David

2006-01-01

165

Apoptosis and Tumor Resistance Conferred by Par-4  

PubMed Central

Par-4 is a tumor suppressor protein with a pro-apoptotic function. Epigenetic silencing of Par-4 is seen in diverse tumors, and Par-4 knockout mice develop spontaneous tumors in various tissues. Endogenous Par-4 is essential for sensitization of cells to diverse apoptotic stimuli, whereas ectopic expression of Par-4 can selectively induce apoptosis in cancer cells. The cancer-specific pro-apoptotic action of Par-4 resides in its centrally located SAC domain. This chapter reviews a novel mouse model with ubiquitous expression of the SAC domain. These SAC transgenic mice display normal development and life span, and, most importantly, are resistant to spontaneous, as well as oncogene-induced, autochthonous tumors. The tumor resistant phenotype and undetectable toxicity of SAC in vivo suggests the SAC domain possesses tremendous therapeutic potential. PMID:18836307

Zhao, Yanming; Rangnekar, Vivek M.

2009-01-01

166

Primary retroperitoneal Müllerian adenocarcinoma arising from endometriosis.  

PubMed

Primary retroperitoneal Müllerian adenocarcinoma (PRMA) is an extremely rare tumor and the cause remains unknown. We report a case of PRMA arising from endometriosis. A 52-year-old woman with a history of malignant lymphoma underwent a follow-up computed tomography scan, which revealed a retroperitoneal tumor. Immunohistochemical analysis of tumor resected during laparoscopic surgery showed adenocarcinoma positive for cytokeratin 7 and negative for cytokeratin 20. The patient had undergone hysterectomy and bilateral salpingo-oophorectomy 14 years ago for myoma uteri and endometrial cysts and was treated with estrogen-replacement therapy. The size of the tumor increased and laparotomy was performed. Histopathological examination showed adenocarcinoma resembling endometrial adenocarcinoma, which stained positive for cancer antigen 125, cancer antigen 19-9, estrogen receptor, and progesterone receptor immunohistochemically. The focus of the endometriosis was found at the edge of the tumor, and the stromal cells around the tumor cells were CD10 positive. The patient was diagnosed as having PRMA arising from endometriosis, and treated with adjuvant chemotherapy. PMID:24888958

Tanaka, Kei; Kobayashi, Yoichi; Shibuya, Hiromi; Nishigaya, Yoshiko; Momomura, Mai; Matsumoto, Hironori; Iwashita, Mitsutoshi

2014-06-01

167

Crystal plasticity finite element analysis of deformation behaviour in SAC305 solder joint  

NASA Astrophysics Data System (ADS)

Due to the awareness of the potential health hazards associated with the toxicity of lead (Pb), actions have been taken to eliminate or reduce the use of Pb in consumer products. Among those, tin (Sn) solders have been used for the assembly of electronic systems. Anisotropy is of significant importance in all structural metals, but this characteristic is unusually strong in Sn, making Sn based solder joints one of the best examples of the influence of anisotropy. The effect of anisotropy arising from the crystal structure of tin and large grain microstructure on the microstructure and the evolution of constitutive responses of microscale SAC305 solder joints is investigated. Insights into the effects of key microstructural features and dominant plastic deformation mechanisms influencing the measured relative activity of slip systems in SAC305 are obtained from a combination of optical microscopy, orientation imaging microscopy (OIM), slip plane trace analysis and crystal plasticity finite element (CPFE) modeling. Package level SAC305 specimens were subjected to shear deformation in sequential steps and characterized using optical microscopy and OIM to identify the activity of slip systems. X-ray micro Laue diffraction and high energy monochromatic X-ray beam were employed to characterize the joint scale tensile samples to provide necessary information to be able to compare and validate the CPFE model. A CPFE model was developed that can account for relative ease of activating slip systems in SAC305 solder based upon the statistical estimation based on correlation between the critical resolved shear stress and the probability of activating various slip systems. The results from simulations show that the CPFE model developed using the statistical analysis of activity of slip system not only can satisfy the requirements associated with kinematic of plastic deformation in crystal coordinate systems (activity of slip systems) and global coordinate system (shape changes) but also this model is able to predict the evolution of stress in joint level SAC305 sample.

Darbandi, Payam

168

Notch-1 signaling promotes the cyclinD1-dependent generation of mammary tumor-initiating cells that can revert to bi-potential progenitors from which they arise.  

PubMed

In a previous work, we reported that young transgenic (Tg) mice expressing the intracellular domain of Notch1 (N1(IC)) showed expansion of lin(-) CD24(+) CD29(high) mammary cells enriched for stem cells and later developed mammary tumors. Mammary tumor formation was abolished or greatly reduced in cyclin D1(-/-) or cyclin D1(+/-) N1(IC) Tg mice, respectively. Here, we studied the epithelial cell subsets present in N1(IC)-induced tumors. CD24(-) CD29(int) and CD24(+) CD29(high) cells were found to be present at low numbers in tumors. The latter had the same properties as those expanded in young Tg females, and neither cell population showed tumor-initiating potential nor were they required for maintenance of tumors after transplantation. CD24(int) CD29(int) cells were identified as tumor-initiating and mammosphere-forming cells and represent a large percentage tumor cells in this model. Their number was significantly lower in tumors from cyclin D1(+/-) N1(IC) Tg mice. Using cyclin D1 shRNA knockdown, we also show that N1(IC)-induced tumor cells remain addicted to cyclin D1 for growth and survival. Interestingly, at lower levels of cyclin D1 or after transplantation in the presence of normal mammary cells, these N1(IC)-expressing tumor cells reverted to a state of low malignancy and differentiate into duct-like structures. They seem to adopt the fate of bi-potential stem/progenitor cells similar to that of the expanded CD24(+) CD29(high) stem/progenitor cells from which they are likely to be derived. Our data indicate that decreasing cyclin D1 levels would be an efficient treatment for tumors induced by N1 signaling. PMID:22907433

Ling, H; Jolicoeur, P

2013-07-18

169

Open Reintervention for Aneurysmal Sac Enlargement after EVAR  

PubMed Central

We performed a late open reintervention for aneurysmal sac enlargement due to persistent type 2 endoleak (PT2EL) after EVAR for 8 of 286 patients. Surgical techniques are as follows: (1) The entire aneurysmal body was exposed. (2) All the aortic branched vessels were ligated. (3) The aneurysmal sac was opened followed by the performance of complete hemostasis. (4) An equine pericardium was wrapped and sutured to the aneurysmal sac to for reinforcement. This method is considered to be one of the feasible options for the treatment of aneurysmal sac re-enlargement after EVAR. PMID:25298845

Hiraoka, Arudo; Hirai, Yuuki; Tamura, Kentaro; Totsugawa, Toshinori; Ishida, Atsuhisa; Sakaguchi, Taichi; Yoshitaka, Hidenori

2014-01-01

170

Whisker Formation on SAC305 Soldered Assemblies  

NASA Astrophysics Data System (ADS)

This article describes the results of a whisker formation study on SAC305 assemblies, evaluating the effects of lead-frame materials and cleanliness in different environments: low-stress simulated power cycling (50-85°C thermal cycling), thermal shock (-55°C to 85°C), and high temperature/high humidity (85°C/85% RH). Cleaned and contaminated small outline transistors, large leaded quad flat packs (QFP), plastic leaded chip carrier packages, and solder balls with and without rare earth elements (REE) were soldered to custom designed test boards with Sn3Ag0.5Cu (SAC305) solder. After assembly, all the boards were cleaned, and half of them were recontaminated (1.56 µg/cm2 Cl-). Whisker length, diameter, and density were measured. Detailed metallurgical analysis on components before assembly and on solder joints before and after testing was performed. It was found that whiskers grow from solder joint fillets, where the thickness is less than 25 µm, unless REE was present. The influence of lead-frame and solder ball material, microstructure, cleanliness, and environment on whisker characteristics is discussed. This article provides detailed metallurgical observations and select whisker length data obtained during this multiyear testing program.

Meschter, S.; Snugovsky, P.; Bagheri, Z.; Kosiba, E.; Romansky, M.; Kennedy, J.; Snugovsky, L.; Perovic, D.

2014-11-01

171

Pathology of pineal region tumors  

Microsoft Academic Search

Various histological types of tumors arise in the pineal region. The most common tumors are pineal parenchymal tumors and germ cell tumors. Pineal parenchymal tumors are divided into pineocytoma, pineal parenchymal tumor with intermediate differentiation and pineoblastoma. Pineocytomas are well-differentiated tumors and retain the morphological and immunohistochemical features of pineal parenchymal cells. Lobular architectures and pineocytomatous rosettes are also typical

Junko Hirato; Yoichi Nakazato

2001-01-01

172

Courrier interne Livraison Cueillette Dlai de livraison Sac de courrier  

E-print Network

Courrier interne Livraison Cueillette D�lai de livraison Sac de courrier Entre 6h30-9h00 Entre 16h ouvrable) Bleu Courrier externe Postes Canada Livraison Cueillette D�lai de livraison Sac de courrier Entre le jour m�me. Rouge Courrier h�pitaux et centres de recherche Livraison Cueillette D�lai de livraison

Charette, André

173

82. SAC control center underground structure sections and unit substation ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

82. SAC control center underground structure sections and unit sub-station details, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

174

83. SAC control center administration section and underground structure elevations ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

83. SAC control center administration section and underground structure elevations and sections, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

175

85. Command HQ. SAC control center (MOD) new work cross ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

85. Command HQ. SAC control center (MOD) new work cross section, drawing number AW-30-02-07, dated 7 February, 1962 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

176

86. SAC control center administration section underground structure and theater ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

86. SAC control center administration section underground structure and theater sections and elevations, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

177

National Aeronautics and Space Administration Aquarius/SAC-D  

E-print Network

National Aeronautics and Space Administration Aquarius/SAC-D Sea Surface Salinity from Space #12 Salinity and the Water Cycle ............................................................ 6 Salinity;AQUARIUS I Sea Surface Salinity from Space4 Aquarius/SAC-D: Sea Surface Salinity from Space Aquarius

Waliser, Duane E.

178

Differential air sac pressures in diving tufted ducks Aythya fuligula.  

PubMed

The air in the respiratory system of diving birds contains a large proportion of the body oxygen stores, but it must be in the lungs for gas exchange with blood to occur. To test the hypothesis that locomotion induces mixing of air sac air with lung air during dives, we measured differential pressures between the interclavicular and posterior thoracic air sacs in five diving tufted ducks Aythya fuligula. The peak differential pressure between posterior thoracic and interclavicular air sacs, 0.49+/-0.13 kPa (mean +/- s.d.), varied substantially during underwater paddling as indicated by gastrocnemius muscle activity. These data support the hypothesis that locomotion, perhaps through associated abdominal muscle activity, intermittently compresses the posterior air sacs more than the anterior ones. The result is differential pressure fluctuations that might induce the movement of air between air sacs and through the lungs during dives. PMID:9716518

Boggs, D F; Butler, P J; Wallace, S E

1998-09-01

179

Multilobular Lacrimal Sac Diverticulum Presenting as a Lower Eyelid Mass  

PubMed Central

Lacrimal sac diverticulum is a rare condition, and its various symptoms complicate differential diagnosis. We present cases of a peculiar type of lacrimal diverticulum. A 5-year-old girl and a 50-year-old woman presented with a protruding mass inferior to the medial canthus. Each lacrimal system was patent to irrigation. The masses compressed and distorted the lacrimal passage and had no apparent connection with the lacrimal sac in dacryocystography or computed tomography. Surgical exploration and complete excision of the masses were completed. Each patient had an inverted Y- and an inverted V-shaped multilobular cystic mass that was pathologically confirmed as a lacrimal sac diverticulum. Lacrimal sac diverticula may rarely take the form of a multilobular cyst and can present as a lower lid mass. We speculate that an abnormality in lacrimal embryogenesis resulted in multiple blind pouches, a peculiar type of lacrimal sac diverticulum. PMID:22870030

Kim, Jung Hoon; Chang, Hae Ran

2012-01-01

180

Courses and Instructors to be Included in the SACS Faculty Roster The SACS Faculty Roster will include instructors for all courses taught for NC State credit in fall 2012 and  

E-print Network

Courses and Instructors to be Included in the SACS Faculty Roster The SACS Faculty Roster. This is the reporting requirement established by SACS. Which Instructors will be included in the SACS Faculty Roster

Liu, Paul

181

[Mediastinal germ cell tumors: anatomopathology, classification, teratomas and malignant tumors].  

PubMed

Mediastinal germ cell tumors are rare tumors. It is classic to divide those tumors into two categories, seminomas and nonseminomatous germ cell tumors: teratomas (mature or immature), embryonal carcinomas, yolk sac tumors, and choriocarcinomas. Each histological sub-type can be associated to another sub-type that realise a so-called mixed germ cell tumor. Diagnosis strategy is currently well codified for malignant mediastinal germ cell tumors. It greatly benefits from tumoral markers (alpha-fetoprotein and beta human chorionic gonadotrophin). For instance, the treatment strategy still raises some specific problems to each histological type. The treatment of seminomatous tumors is standardised--chemotherapy/surgery on residual tumor greater than 3 cm/radiotherapy on viable persistent residual tumors--and provides very satisfying results. As for the nonseminomatous germ cell tumors, the situation is dramatically different. The treatment strategy is less standardised--association of chemotherapy and surgery--and the prognosis is very severe. PMID:20207298

Chetaille, B; Massard, G; Falcoz, P-E

2010-02-01

182

Mechanical Engineering Department SACS Accreditation Review Form Spring 2008 1 MMMeeeccchhhaaannniiicccaaalll EEEnnngggiiinnneeeeeerrriiinnnggg DDDeeepppaaarrrtttmmmeeennnttt  

E-print Network

Mechanical Engineering Department SACS Accreditation Review Form ­ Spring 2008 1 AAAccccccrrreeedddiiitttaaatttiiiooonnn RRReeevvviiieeewww FFFooorrrmmm University information web site (http://www.sacs.vt.edu/) Student

Virginia Tech

183

Fibrotic nodule arising from the cerebellopontine angle.  

PubMed

The authors present an extremely rare case of a fibrotic nodule arising from the cerebellopontine (CP) angle. A 57-year-old male had suffered from hearing disturbance and tinnitus for several years. Computed tomography revealed a high-density mass in the left CP angle with little enhancement after intravenous administration of contrast media. Magnetic resonance imaging (MRI) showed a very hypointense mass on T2-weighted imaging. T1-weighted MRI with gadolinium revealed very faint, delayed enhancement of the tumor. The patient underwent surgical resection of the tumor. Histopathologically the lesion comprised entirely fibrotic tissue consisting of thick collagenous fibers and sclerosing blood vessels with a few intervening viable cells with, partly, the immunophenotype of arachnoid cells. Intracranial fibrotic nodules are extremely rare. This tumor, however, had some radiological features similar to those of other, more common, tumors for example meningiomas or solitary fibrous tumors; it was, therefore, difficult to distinguish it from the others. It is believed that intracranial fibrotic nodules usually have benign, non-neoplastic characteristics, although their natural history is not yet fully understood. It is, therefore, necessary to be able to perform a differential diagnosis that will distinguish this rare condition from other intracranial fibrous neoplasms that occasionally have malignant features. PMID:22678097

Amano, Toshiyuki; Suzuki, Satoshi O; Mizoguchi, Masahiro; Yoshimoto, Koji; Nakamizo, Akira; Murata, Hideki; Iwaki, Toru; Sasaki, Tomio

2013-04-01

184

Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis  

Microsoft Academic Search

Neuropilins (NP1 and NP2) are vascular endothelial growth factor (VEGF) receptors that mediate developmental and tumor angiogenesis. Transgenic mice, in which both NP1 and NP2 were targeted (NP1\\/NP2\\/) died in utero at E8.5. Their yolk sacs were totally avascular. Mice deficient for NP2 but heterozygous for NP1 (NP1+\\/NP2\\/) or deficient for NP1 but heterozygous for NP2 (NP1-\\/-NP2+\\/-) were also embryonic

Seiji Takashima; Masafumi Kitakaze; Masanori Asakura; Hiroshi Asanuma; Shoji Sanada; Fumi Tashiro; Hitoshi Niwa; Jun-Ichi Miyazaki; Seiichi Hirota; Yukihiko Kitamura; Takashi Kitsukawa; Hajime Fujisawa; Michael Klagsbrun; Masatsugu Hori

2002-01-01

185

79. Sac digital network (Sacdin), summary fault indicator at top, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

79. Sac digital network (Sacdin), summary fault indicator at top, south side - Ellsworth Air Force Base, Delta Flight, Launch Control Facility, County Road CS23A, North of Exit 127, Interior, Jackson County, SD

186

From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.  

PubMed

Testicular carcinoma represents only 1% of all neoplasms in men, but it is the most common malignancy in the 15-34-year-old age group. Germ cell tumors constitute 95% of all testicular tumors. Germ cell tumors are a varied group of neoplasms whose imaging features reflect their underlying histologic characteristics. Seminomas are generally well-defined homogeneous lesions, whereas the nonseminomatous tumors (embryonal carcinoma, yolk sac tumor, choriocarcinoma, teratoma, and mixed germ cell tumor) have a much more varied appearance. Germ cell tumors follow a predictable pattern of spread via the lymphatic drainage to the retroperitoneal nodes. Choriocarcinoma, which has a proclivity for early hematogenous spread, is a notable exception. Testicular tumors may also arise from the sex cords (Sertoli cells) and stroma (Leydig cells). Although 90% of these tumors are benign, there are no reliable imaging criteria to differentiate them from malignant masses. Some benign testicular masses can be recognized, obviating an unwarranted orchiectomy. A dilated rete testis is a normal variant and appears as a series of small tubules near the mediastinum testis. Other benign lesions that can be suspected on the basis of imaging findings and history include intratesticular cysts, epidermoid cysts, congenital adrenal hyperplasia, and sarcoidosis. PMID:11796908

Woodward, Paula J; Sohaey, Roya; O'Donoghue, Michael J; Green, Douglas E

2002-01-01

187

Development of the Laryngeal Air Sac in Chimpanzees  

Microsoft Academic Search

Though many nonhuman primates possess a laryngeal sac, the great apes are unique in their great size. Though an enlarged sac\\u000a probably arose in their common ancestor, its functional adaptations remain a matter of debate. Its development in extant great\\u000a apes is likely to provide valuable information to clarify the issue. We used magnetic resonance imaging to examine the development

Takeshi Nishimura; Akichika Mikami; Juri Suzuki; Tetsuro Matsuzawa

2007-01-01

188

SACS Accreditation Form, Modified 11/15/2012 School of ECE Ph.D. Final Defense  

E-print Network

SACS Accreditation Form, Modified 11/15/2012 School of ECE Ph.D. Final Defense SACS Accreditation Evaluation Form The PhD Objectives for the SACS Accreditation are 1. Students will perform original research risks and payoffs. #12;SACS Accreditation Form, Modified 11/15/2012 Grammar, Mechanics, Organization

Bennett, Gisele

189

Application of SAC88 to Estimating Hydrologic Effects of Fire on a  

E-print Network

Application of SAC88 to Estimating Hydrologic Effects of Fire on a Watersheds1 R. Larry Ferral2 Abstract: SAC88 is a major revision of the Sacramento Model, which was developed in 1969 with minor exceeds the rate at which water can enter the upper level storages. SAC88 REVISIONS SAC88, a major

Standiford, Richard B.

190

SACS Accreditation Form, Modified 11/15/2012 School of ECE Ph.D. Proposal Exam  

E-print Network

SACS Accreditation Form, Modified 11/15/2012 School of ECE Ph.D. Proposal Exam SACS Accreditation Evaluation Form The PhD Objectives for the SACS Accreditation are 1. Students will perform original research and citation format used throughout document. Graphs and charts used appropriately to present data. #12;SACS

Bennett, Gisele

191

M?llerian Adenosarcoma Arising From Rectal Endometriosis  

PubMed Central

A Müllerian adenosarcoma is an extremely rare tumor characterized by a stromal component of usually low-grade malignancy and by a benign glandular epithelial component. A Müllerian adenosarcoma occurs mainly in the uterus, but also in extrauterine locations. Extrauterine Müllerian adenosarcomas are thought to arise from endometriotic deposits. A 36-year-old female presented to Daegu Catholic University Medical Center with a symptom of loose stool for several months. The imaging studies revealed a rectal mass, so she underwent a laparoscopic low anterior resection. Although extemporary pathology revealed an inflammatory myofibroblastic tumor, the final histologic diagnosis was a Müllerian adenosarcoma arising from rectal endometriosis. To our knowledge, except a concomitant rectal villotubular adenoma, cases of Müllerian adenosarcomas arising the rectal wall are rare. An adenosarcoma arising from endometriosis should be considered in the differential diagnosis of a pelvic mass, even one appearing in rectal wall, because ectopic endometrial tissue exists everywhere. PMID:25360431

Yang, Chunseok; Oh, Hoon Kyu

2014-01-01

192

Automatic segmentation and classification of gestational sac based on mean sac diameter using medical ultrasound image  

NASA Astrophysics Data System (ADS)

Ultrasound is an effective multipurpose imaging modality that has been widely used for monitoring and diagnosing early pregnancy events. Technology developments coupled with wide public acceptance has made ultrasound an ideal tool for better understanding and diagnosing of early pregnancy. The first measurable signs of an early pregnancy are the geometric characteristics of the Gestational Sac (GS). Currently, the size of the GS is manually estimated from ultrasound images. The manual measurement involves multiple subjective decisions, in which dimensions are taken in three planes to establish what is known as Mean Sac Diameter (MSD). The manual measurement results in inter- and intra-observer variations, which may lead to difficulties in diagnosis. This paper proposes a fully automated diagnosis solution to accurately identify miscarriage cases in the first trimester of pregnancy based on automatic quantification of the MSD. Our study shows a strong positive correlation between the manual and the automatic MSD estimations. Our experimental results based on a dataset of 68 ultrasound images illustrate the effectiveness of the proposed scheme in identifying early miscarriage cases with classification accuracies comparable with those of domain experts using K nearest neighbor classifier on automatically estimated MSDs.

Khazendar, Shan; Farren, Jessica; Al-Assam, Hisham; Sayasneh, Ahmed; Du, Hongbo; Bourne, Tom; Jassim, Sabah A.

2014-05-01

193

Orbital chondrosarcoma arising from paranasal sinuses.  

PubMed

Orbital chondrosarcoma arising from paranasal sinuses or from the nasal cavity with orbital extension is highly unusual. The aim of this report is to describe our multidisciplinary experience in the treatment of three patients with extensive sino-orbital chondrosarcomas. The patients were aged 43, 75 and 63 years, and the tumors originated from the maxillary, sphenoidal, and ethmoidal sinuses, respectively. Magnetic resonance imaging studies showed homogeneously hypointense lesions on T1-weighted scans, which were hyperintense on T2-weighted images. Intranasal endoscopic surgery alone or in combination with other conventional surgical approaches was the main therapeutic choice. Two patients had recurrences treated with wider surgical removal. Fractionated stereotactic radiotherapy was used in two cases. Two patients had histopathological grade I tumor and one had grade III chondrosarcoma. No patient had regional spread or distant metastasis. All patients were disease-free at 4, 2, and 3 years, respectively, following their last therapeutic interventions. Endoscopic surgery results in lesser morbidity for chondrosarcomas arising from paranasal sinuses and extending into posterior parts of the orbit. However, because control of surgical margins may not be complete, recurrences may occur justifying more radical approaches. PMID:23129506

Kiratli, Hayyam; Dikmeta?, Ozlem; Tarlan, Berçin; Onerci, Metin

2013-08-01

194

Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice  

PubMed Central

Tumor blood vessels are leaky and immature, which causes inadequate blood supply to tumor tissues resulting in hypoxic microenvironment and promotes metastasis. Here we have explored tumor vessel modulating activity of Sac-1004, a recently developed molecule in our lab, which directly potentiates VE-cadherin-mediated endothelial cell junction. Sac-1004 could enhance vascular junction integrity in tumor vessels and thereby inhibit vascular leakage and enhance vascular perfusion. Improved perfusion enabled Sac-1004 to have synergistic anti-tumor effect on cisplatin-mediated apoptosis of tumor cells. Interestingly, characteristics of normalized blood vessels namely reduced hypoxia, improved pericyte coverage and decreased basement membrane thickness were readily observed in tumors treated with Sac-1004. Remarkably, Sac-1004 was also able to inhibit lung and lymph node metastasis in MMTV and B16BL6 tumor models. This was in correlation with a reduction in epithelial-to-mesenchymal transition of tumor cells with considerable diminution in expression of related transcription factors. Moreover, cancer stem cell population dropped substantially in Sac-1004 treated tumor tissues. Taken together, our results showed that direct restoration of vascular junction could be a significant strategy to induce normalization of tumor blood vessels and reduce metastasis. PMID:24811731

Agrawal, Vijayendra; Maharjan, Sony; Kim, Kyeojin; Kim, Nam-Jung; Son, Jimin; Lee, Keunho; Choi, Hyun-Jung; Rho, Seung-Sik; Ahn, Sunjoo; Won, Moo-Ho; Ha, Sang-Jun; Koh, Gou Young; Kim, Young-Myeong; Suh, Young-Ger; Kwon, Young-Guen

2014-01-01

195

[A solitary neurofibroma arising from the temporal fossa].  

PubMed

Neurofibromas are benign nerve sheath tumors that arise from the nonmyelinating Schwann cells. Generally, neurofibromas can be categorized into dermal and plexiform subtypes. The former subtype is usually associated with a lone peripheral nerve in the integumentary system, while plexiform tumors are associated with many nerve bundles and can originate internally. Rarely, the plexiform tumors can undergo malignant transformation. Neurofibromas are usually found in individuals with neurofibromatosis, which is an autosomal dominant disease. On occasion, an isolated neurofibroma can transpire without being associated with neurofibromatosis. Mostly, these solitary tumors tend to occur in the gastrointestinal system, and neurofibromas of the head and neck are not uncommon, but very rarely they have been reported to occur in the temporal fossa. In this report, we describe a case of a solitary neurofibroma arising from the temporal fossa. PMID:25248275

Tian, Xiaoyan; Luo, Gui; Zhu, Xinhua

2014-07-01

196

The anuran vocal sac: a tool for multimodal signalling  

PubMed Central

Although in anurans the predominant mode of intra- and intersexual communication is vocalization, modalities used in addition to or instead of acoustic signals range from seismic and visual to chemical. In some cases, signals of more than one modality are produced through or by the anuran vocal sac. However, its role beyond acoustics has been neglected for some time and nonacoustic cues such as vocal sac movement have traditionally been seen as an epiphenomenon of sound production. The diversity in vocal sac coloration and shape found in different species is striking and recently its visual properties have been given a more important role in signalling. Chemosignals seem to be the dominant communication mode in newts, salamanders and caecilians and certainly play a role in the aquatic life phase of anurans, but airborne chemical signalling has received less attention. There is, however, increasing evidence that at least some terrestrial anuran species integrate acoustic, visual and chemical cues in species recognition and mate choice and a few secondarily mute anuran species seem to fully rely on volatile chemical cues produced in glands on the vocal sac. Within vertebrates, frogs in particular are suitable organisms for investigating multimodal communication by means of experiments, since they are tolerant of disturbance by observers and can be easily manipulated under natural conditions. Thus, the anuran vocal sac might be of great interest not only to herpetologists, but also to behavioural biologists studying communication systems. PMID:25389375

Starnberger, Iris; Preininger, Doris; Hödl, Walter

2014-01-01

197

Vascular development and hemodynamic force in the mouse yolk sac  

NASA Astrophysics Data System (ADS)

Vascular remodeling of the mouse embryonic yolk sac is a highly dynamic process dependent on multiple genetic signaling pathways as well as biomechanical factors regulating proliferation, differentiation, migration, cell-cell and cell-matrix interactions. During this early developmental window, the initial primitive vascular network of the yolk sac undergoes a dynamic remodeling process concurrent with the onset of blood flow, in which endothelial cells establish a branched, hierarchical structure of large vessels and smaller capillary beds. In this review, we will describe the molecular and biomechanical regulators which guide vascular remodeling in the mouse embryonic yolk sac, as well as live imaging methods for characterizing endothelial cell and hemodynamic function in cultured embryos.

Garcia, Monica; Larina, Irina

2014-08-01

198

Aquarius and the Aquarius/SAC-D Mission  

NASA Technical Reports Server (NTRS)

Aquarius is a combination L-band radiometer and scatterometer designed to map the salinity field at the ocean surface from space. It will be flown on the Aquarius/SAC-D mission, a partnership between the USA space agency (NASA) and Argentine space agency (CONAE). The mission is composed of two parts: (a) The Aquarius instrument being developed as part of NASA.s Earth System Science Pathfinder (ESSP) program; and (b) SAC-D the fourth spacecraft service platform in the CONAE Satellite de Aplicaciones Cientificas (SAC) program. The primary focus of the mission is to monitor the seasonal and interannual variations of the salinity field in the open ocean. The mission also meets the needs of the Argentine space program for monitoring the environment and for hazard detection and includes several instruments related to these goals.

LeVine, D. M.; Lagerloef, G. S. E.; Torrusio, S.

2010-01-01

199

Intratesticular borderline serous tumor.  

PubMed

Neoplasms resembling ovarian serous tumors rarely arise in the male genital organs. Müllerian histogenesis of this tumor has been suggested. We report a case of an intratesticular borderline serous tumor accidentally discovered during the course of a preoperative workup in a 72-year-old man admitted for left upper lobectomy for squamous cell carcinoma of the lung. PMID:17118032

Abdullah, Layla Saleh; Gupta, Richta; Arnst, A

2006-12-01

200

ISTC SAC Seminar "New Perspectives of High Energy Physics"  

E-print Network

Medical spinoffs of High Energy Physics Knowledge and technology transfer from High Energy Physics (vi 13th ISTC SAC Seminar "New Perspectives of High Energy Physics" 15 September, 2010, Budker of Budker Institute of Nuclear Physics of Siberian Branch of the Russian Academy of Sciences (BINP SB RAS

201

Embryology of the Human Endolymphatic Duct and Sac  

Microsoft Academic Search

Endolymphatic sac specimens from human embryos, ranging in age from 8 to 20 weeks, were examined in order to get a good understanding of the embryological development. The gross development can be separated into three phases, with the first phase terminating around week 10, the second phase between weeks 11 and 15–16 and the third phase lasting to week 20.

Dan Bagger-Sjöbäck

1991-01-01

202

Aquarius\\/SAC-D Ocean Salinity Mission Science Overview  

Microsoft Academic Search

Scheduled for launch in 2009, the international Aquarius\\/SAC-D satellite will begin a mission to map the global sea surface salinity (SSS) field and its variability from space. The overarching scientific goal is to provide the essential data to study the interactions between the ocean circulation, global water cycle and climate. Key scientific issues to address are (1) mapping large expanses

G. S. E. Lagerloef; Y. Chao; F. Raul Colomb

2006-01-01

203

TMACS Test Procedure TP008: SACS Interface. Revision 5  

SciTech Connect

The TMACS Software Project Test Procedures translate the project`s acceptance criteria into test steps. Software releases are certified when the affected Test Procedures are successfully performed and the customers authorize installation of these changes. This Test Procedure tests the TMACS SACS Interface functions.

Washburn, S.J.

1994-05-31

204

Is routine histological evaluation of pediatric hernial sac necessary?  

Microsoft Academic Search

Advocates of routine histological examination of hernial sac recommend it for surgical quality assurance, to report injuries to the vas deferens, and to detect occult malignant and benign diseases such as tuberculosis. However, the value of this routine examination is debated in this era of cost containment in health care. We conducted a retrospective study of our practice and reviewed

Khurram Siddiqui; Zafar Nazir; SyedSohail Ali; Shahid Pervaiz

2004-01-01

205

The annular hematoma of the shrew yolk-sac placenta.  

PubMed

The annular hematoma of the shrew, Blarina brevicauda, is a specialized portion of the yolk-sac wall. In this study, we have examined the fine structure of the different cellular components of the anular hematoma. Small pieces of the gestation sacs from seven pregnant shrews were fixed in glutaraldehyde and osmium tetroxide and processed for transmission electron microscopy. In the area of the trophoblastic curtain, the maternal capillary endothelial cells were hypertrophied and syncytial trophoblast surrounded the capillaries. Cellular trophoblast covered part of the luminal surface of the curtain region, whereas masses of apparently degenerating syncytium were present on other areas of the surface. Maternal erythrocytes, released into the uterine lumen from the curtain region, were phagocytized and degraded by the columnar cells of the trophoblastic annulus. No evidence of iron or pigment accumulation was evident in the parietal endodermal cells underlying the annular trophoblast. Parietal endodermal cells were characterized by cuboidal shape, widely dilated intercellular spaces, and cytoplasm containing granular endoplasmic reticulum. Endodermal cells of the visceral yolk-sac accumulated large numbers of electron-dense granules as well as glycogen in their cytoplasm. Hemopoietic areas and vitelline capillaries were found subjacent to the visceral endoderm. The various portions of the yolk-sac wall of Blarina appear to perform complementary functions which are probably important in maternal-fetal iron transfer. PMID:677046

King, B F; Enders, A C; Wimsatt, W A

1978-05-01

206

SAC 2006 REGISTRATION FORM August 17-18, 2006 Montreal, Quebec, Canada  

E-print Network

SAC 2006 REGISTRATION FORM August 17-18, 2006 Montreal, Quebec, Canada Surname: ________________________________ ************************************************************************* Mail or FAX this form to: (514) 848-3171 Attn: Ms. Sheryl TABLAN SAC 2006 Concordia Institute

Youssef, Amr M.

207

45. SAC conference room 2A8, second floor, Dwing, building 500, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. SAC conference room 2A8, second floor, D-wing, building 500, looking southeast - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

208

81. SAC control center aboveground addition elevations, drawing number AW300209, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

81. SAC control center aboveground addition elevations, drawing number AW-30-02-09, dated 15 October, 1962 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

209

Apomictic embryo sac development in a diploid sorghum line and its derived polyploids  

E-print Network

was studied in diploids and induced polyploids of the WS line. Almost all of the ovules examined contained fully-differentiated embryo sacs of the Polygonum type (Fig. 3) normal for sexual embryo sacs in sorghum (Tang, 1977). Enlarged cells, resembling... was studied in diploids and induced polyploids of the WS line. Almost all of the ovules examined contained fully-differentiated embryo sacs of the Polygonum type (Fig. 3) normal for sexual embryo sacs in sorghum (Tang, 1977). Enlarged cells, resembling...

Stover, Eddie Wayne

2012-06-07

210

Principles of Good Practice Certification Louisiana Tech University, the Louisiana Board of Regents, and SACS require that credit  

E-print Network

, and SACS require that credit courses, academic degrees, and certificate programs in which the majority." SACS includes courses/programs delivered by correspondence, audio, video, or computer technologies

Selmic, Sandra

211

28/04/2009 SAC meeting IRAM Grenoble 1 Bolometers at the 30m  

E-print Network

28/04/2009 SAC meeting IRAM Grenoble 1 Bolometers at the 30m telescope: future instruments, GISMO & other prototypes S.Leclercq 28/04/2009 #12;28/04/2009 SAC meeting IRAM Grenoble 2 Content 1. Conclusion & next steps #12;28/04/2009 SAC meeting IRAM Grenoble 3 Bands available at the 30m 24 90 40 36

Leclercq, Samuel

212

38 CFR Appendix A to Part 41 - Data Collection Form (Form SF-SAC)  

Code of Federal Regulations, 2012 CFR

...2012-07-01 false Data Collection Form (Form SF-SAC) A Appendix A to Part 41 Pensions, Bonuses...to Part 41—Data Collection Form (Form SF-SAC) Note: Data Collection Form SF-SAC and instructions for its completion may be...

2012-07-01

213

Department of Computer Science, University of California, Santa Barbara SAC 2003, March 9-12, 2003  

E-print Network

Department of Computer Science, University of California, Santa Barbara SAC 2003, March 9-12, 2003 #12;2SAC 2003, March 9-12, 2003 Introduction Visualization of proteins is crucial in understandingGL/Direct3D We tackle some problems related to visualizing complex molecular scenes using Java 3D #12;3SAC

Can, Tolga

214

Want to be part of the UITE Student Advisory Committee (SAC)?  

E-print Network

Want to be part of the UITE Student Advisory Committee (SAC)? Being part of the UITE Student Advisory Committee (SAC) is a great way to get involved in the College of Education, make new friends, meet faculty & staff, learn leadership skills, and have fun! The UITE Student Advisory Committee (SAC) is only

Simons, Jack

215

The vocal sac as a visual cue in anuran communication: an experimental analysis using video playback  

E-print Network

The vocal sac as a visual cue in anuran communication: an experimental analysis using video by inflation of a conspicuous vocal sac. We presented female tu´ngara frogs, Physalaemus pustulosus, with acoustic playback of the male advertisement call, synchronized with a video playback of vocal sac inflation

Ryan, Michael J.

216

First Description of Egg Sacs and Early Larval Development in Hynobiid Salamanders (Urodela, Hynobiidae, Batrachuperus)  

E-print Network

First Description of Egg Sacs and Early Larval Development in Hynobiid Salamanders (Urodela- ganensis). We compare these observations with those of other hynobiid species. The egg sac of B. gorganensis var- ied from 80 to 182 mm (mean 132.5), and in width from 16 to 22.5 mm (mean 18.9). Single sacs

Alvarez, Nadir

217

Draft Submitted to J-SAC Circuit Modeling Methodology for UWB Omnidirectional Small  

E-print Network

Draft Submitted to J-SAC - 1 - Circuit Modeling Methodology for UWB Omnidirectional Small Antennas Submitted to J-SAC - 2 - Circuit Modeling Methodology for UWB Omnidirectional Small Antennas Stanley B. T to J-SAC - 3 - I. INTRODUCTION In 2002, the FCC released the use of Ultra-wideband (UWB) transmission

Southern California, University of

218

38 CFR Appendix A to Part 41 - Data Collection Form (Form SF-SAC)  

Code of Federal Regulations, 2013 CFR

...2013-07-01 false Data Collection Form (Form SF-SAC) A Appendix A to Part 41 Pensions, Bonuses...to Part 41—Data Collection Form (Form SF-SAC) Note: Data Collection Form SF-SAC and instructions for its completion may be...

2013-07-01

219

Ionic and potential changes of the endolymphatic sac induced by endolymph volume changes  

E-print Network

Ionic and potential changes of the endolymphatic sac induced by endolymph volume changes Alec N The endolymphatic sac (ES) is believed to be the locus for endolymph volume regulation in the inner ear. It has in the ES, suggesting that function of the sac varies according to endolymph volume status. In the present

Salt, Alec N.

220

United Campus Ministry Student Advisory Council: UCM-SAC Constitution and Bylaws  

E-print Network

United Campus Ministry Student Advisory Council: UCM-SAC Constitution and Bylaws Florida Atlantic Council (UCM-SAC). Article 2. Purpose United Campus Ministry(UCM) exists at Florida Atlantic University Advisory Council (UCM-SAC) will assist UCM by providing formal input from FAU students on the spiritual

Fernandez, Eduardo

221

Harnessing the Power of GPUs without Losing Abstractions in SAC and ARRAYOL: A Comparative Study  

E-print Network

Harnessing the Power of GPUs without Losing Abstractions in SAC and ARRAYOL: A Comparative Study a high-level general purpose array processing lan- guage, Single Assignment C (SAC) to CUDA. Using a real-specific language. Keywords-ARRAYOL, SAC, GPGPU, CUDA, OPENCL I. INTRODUCTION Over recent years, using Graphics

Paris-Sud XI, Université de

222

Mammalian laryngseal air sacs add variability to the vocal tract impedance: Physical and computational modeling  

E-print Network

Mammalian laryngseal air sacs add variability to the vocal tract impedance: Physical Cavities branching off the main vocal tract are ubiquitous in nonhumans. Mammalian air sacs exist in human. The present paper focuses on acoustical functions of the air sacs. The hypotheses are investigated on whether

Tokuda, Isao

223

38 CFR Appendix A to Part 41 - Data Collection Form (Form SF-SAC)  

...2014-07-01 false Data Collection Form (Form SF-SAC) A Appendix A to Part 41 Pensions, Bonuses...to Part 41—Data Collection Form (Form SF-SAC) Note: Data Collection Form SF-SAC and instructions for its completion may be...

2014-07-01

224

Reply to "Comments on `Refinement of COSMO-SAC and the Applications'" S. I. Sandler*  

E-print Network

Reply to "Comments on `Refinement of COSMO-SAC and the Applications'" S. I. Sandler* Department, Pasadena, California 91125 Sir: We agree that the mathematical formula for G*res in COSMO-SAC is equivalent of these equations. There are also important differences in implementation between COSMO-RS and COSMO-SAC (for

Goddard III, William A.

225

Morphological changes of the endolymphatic sac induced by microinjection of articial endolymph into the cochlea  

E-print Network

Morphological changes of the endolymphatic sac induced by microinjection of arti¢cial endolymph; accepted 14 August 1999 Abstract Morphological changes of the endolymphatic sac were analyzed in guinea the epithelium of the sac, remain to be elucidated. � 1999 Elsevier Science B.V. All rights reserved. Key words

Salt, Alec N.

226

The Probabilistic Basis for the 2000 SAC/FEMA Steel Moment Frame C. Allin Cornell1  

E-print Network

The Probabilistic Basis for the 2000 SAC/FEMA Steel Moment Frame Guidelines C. Allin Cornell1 for the 2000 SAC/FEMA steel moment frame guidelines. The framework is based on realizing a performance being met. This format has been adopted in the SAC/FEMA guidelines. Keywords Probabilistic performance

Sweetman, Bert

227

Optimisation par colonies de fourmis pour le problme du sac dos multidimensionnel  

E-print Network

Optimisation par colonies de fourmis pour le problème du sac à dos multidimensionnel Inès Alaya (Ant Colony Optimization / ACO) pour résoudre le problème du sac à dos multidimensionnel. L competitive results. MOTS-CL�S : Optimisation par colonies de fourmis, Problème du sac à dos multidimensionnel

Solnon, Christine

228

Preparing the SACS Compliance Report on Faculty Credentials Comprehensive Standard 3.7.1  

E-print Network

Preparing the SACS Compliance Report on Faculty Credentials Comprehensive Standard 3 the qualifications of its faculty. SACS Guidelines When an institution defines faculty qualifications using faculty match both level and the content of each course taught. Required Documentation (SACS Resource Manual

Liu, Paul

229

Culture of Unfertilized Embryo Sacs of Pearl Millet - Pennisetum glaucum (L.) R. Br  

Microsoft Academic Search

The morphology and structure of isolated unfertilized embryo sacs of pearl millet, Pennisetum glaucum (L.) R.Br. is similar to those in situ. In all cultivars a minimum of five intact embryo sacs could be isolated from 30 ovaries per hr. Isolated embryo sacs (30-50%) were viable for four days on MS medium. An increase in the number of polar nuclei

T. V. R. Lakshmi; K. Aruna Lakshmi; Narayana R. Isola

230

A TEST OF WHETHER ECONOMY OR NUTRITION DETERMINES FECAL SAC INGESTION IN NESTING CORVIDS  

Microsoft Academic Search

Parent birds of many species eat the fecal sacs produced by their nestlings. Two hypotheses have been proposed to explain why the parents ingest, rather than simply remove the sacs. (1) The parental nutrition hypothesis proposes that the parent benefits energetically or nutritionally from ingesting the sacs (Morton 1979, Gliick 1988); and (2) the economic disposal hypothesis postulates that parents

KEVIN J. MCGOWAN

231

Pakistan Vet. J., 24(3): 2004 EFFECT OF EXPERIMENTAL YOLK SAC INFECTION WITH ESCHERICHIA  

E-print Network

Pakistan Vet. J., 24(3): 2004 125 EFFECT OF EXPERIMENTAL YOLK SAC INFECTION WITH ESCHERICHIA COLI sac, yolk sac:body weight ratio, antibody titer against Newcastle disease virus (NDV) and analysis:body weight ratio was increased and geometric mean titer against NDV was decreased in serum and yolk

Boyer, Edmond

232

Thymoma type B1 arising in a giant supradiaphragmatic thymolipoma.  

PubMed

Thymolipomas are uncommon tumors of the anterior mediastinum. They may extend into, but rarely stem from, the chest cavity. Furthermore, thymoma arising in a thymolipoma is extremely rare. We report a unique case of thymoma type B1 that originated form a giant thymolipoma located in the chest cavity, which was resected by a lateral thoracotomy in a 23-year-old woman. To our knowledge, this is the first reported case of thymoma type B1 arising within a giant thymolipoma. PMID:24887884

Kaplan, Tevfik; Han, Serdar; Han, Unsal; Atac, Gokce Kaan; Yanik, Serdar

2014-11-01

233

Unusual microtubular cytoskeleton of apomictic embryo sac of Chondrilla juncea L.  

PubMed

The mature apomictic embryo sac of Chondrilla juncea is highly vacuolated and demonstrates a polarization similar to that of the amphimictic gametophyte. The microtubule cytoskeleton of this embryo sac is uncharacteristic and relatively weak. The microtubules are positioned along cell walls and resemble cortical microtubules of somatic cells. They do not form the parallel, brushlike structures observed around the filiform apparatus of synergids in the amphimictic embryo sac. In the apomictic embryo sac, the microtubules of both the egg cell and the central cell develop a cortical-like structure, which is entirely different from the radial arrangement observed around the nuclei in the amphimictic embryo sac. PMID:16736250

Ko?ci?ska-Pajak, M; Bednara, J

2006-05-01

234

SAC-C Mission and the Morning Constellation  

NASA Astrophysics Data System (ADS)

SAC-C is an international Earth observing satellite mission conceived as a partnership between CONAE and NASA, but with additional support in instrumentation and satellite development from the Danish DSRI, the Italian ASI, the French CNES and the Brazilian INPE. A Delta II rocket successfully launched it on November 21st, 2000, from Vandenberg AFB, California, USA. SAC-C has been designed primarily to fulfill the requirements of countries with large extension of territory or scarcely populated like Argentina. Its design is a good compromise between resolution and swath width that makes SAC-C an appropriate tool for global and high dynamic phenomena studies. There are ten instruments on board of SAC-C that will perform different studies, the Multispectral Medium Resolution Scanner (MMRS), provided by CONAE, Argentina, will help in the studies about desertification processes evaluation and their evolution in time (i.e., Patagonia, Argentina), to identify and predict agriculture production, to monitor flood areas and to make studies in coastal and fluvial areas. The MMRS will be associated with a High Resolution Technological Camera (HRTC), also provided by CONAE that will permit improvement in the MMRS resolution in the areas where it will be required. A High Sensitivity Technological Camera (HSTC) is also included in the mission. SAC-C also carries instruments to monitor the condition and dynamics of the terrestrial and marine biosphere and environment (GPS OccuLtation and Passive reflection Experiment (GOLPE)) from NASA/JPL. The Magnetic Mapping Payload, (MMP) developed by the Danish Space Research Institute helps to better understand the Earth's magnetic field and related Sun -Earth interactions .Italian Star Tracker (IST) and Italian Navigation Experiment (INES) developed by the Italian Space Agency, constitute a technological payload that will permit testing a fully autonomous system for attitude and orbit determination. Influence of space radiation on advanced components (ICARE), provided by CNES will permit improvement of risk estimation models for radiation effect on last generation integrated circuit technology. . On June 14th, 2000 CONAE and NASA signed an amendment to the Memorandum of Understanding for the SAC-C mission in order that the SAC-C satellite, were included in a constellation - named "Morning Constellation". It is integrated by USA satellites Landsat 7, EO 1, Terra, and Argentine SAC-C that feature on-board instruments from the United States, Argentina, Denmark, Italy, France, and Japan. The four satellite tracks on the Earth's surface are the same, their orbital height being 705 km and their inclination, 98.21 degrees. They cross the Equator at 10:00, 10:01, 10:15, and 10:30 hours, respectively (local time). Satellites comply with the World Wide Reference System. The Constellation has been working since March 2001 as a single mission and several cooperative activities have been undertaken and will be presented in this paper. Several jointly sponsored technical workshops have been held, and also collaborative spacecraft navigation experiments have been made. One of the objectives of the AM Constellation is the collaboration in the case of emergencies, NASA and CONAE agreed to give preference in those situation in the planification of their satellite acquisitions. From all the possible hazardous events, the most important for the country are fire and floods. In relation to fires, CONAE is presently adapting and developing the algorithms for using MODIS data to generate a fire map product. Additionally research on fire detection is carried out using the data from the HSTC camera. In relation to flooding, CONAE works in cooperation to national institutions providing the data and, in some cases, producing flood extent maps. In particular MMRS data is demonstrating to be very effective due to its spectral and radiometric resolutions, and its large swath which is well suited for extended countries like Argentina.

Colomb, F. R.; Alonso, C.; Hofmann, C.; Frulla, L.; Nollmann, I.; Milovich, J.; Kuba, J.; Ares, F.; Kalemkarian, M.

2002-01-01

235

Spectral Amplitude Coding (SAC)-OCDMA Network with 8DPSK  

NASA Astrophysics Data System (ADS)

Optical code division multiple access (OCDMA) technique is required to meet the increased demand for high speed, large capacity communications in optical networks. In this paper, the transmission performance of a spectral amplitude coding (SAC)-OCDMA network is investigated when a conventional single-mode fiber (SMF) is used as the transmission link using 8DPSK modulation. The DW has a fixed weight of two. Simulation results reveal that the transmission distance is limited mainly by the fiber dispersion when high coding chip rate is used. For a two-user SAC-OCDMA network operating with 2 Gbit/s data rate and two wavelengths for each user, the maximum allowable transmission distance is about 15 km.

Aldhaibani, A. O.; Aljunid, S. A.; Fadhil, Hilal A.; Anuar, M. S.

2013-09-01

236

Chronic, recurrent dacryocystitis from a BB in the lacrimal sac.  

PubMed

Metallic foreign bodies in the lacrimal outflow tract are a rarely reported cause of nasolacrimal duct obstruction. Among the few cases in the literature, 1 consisted of a BB in the nasolacrimal duct. This case report presents a second case of chronic, recurrent dacryocystitis in a child, which occurred secondary to a BB that had become lodged in the lacrimal sac. The metallic foreign body was identified on CT and successfully removed surgically. Exogenous sources of lacrimal sac foreign bodies should be considered in patients with a history of periorbital trauma and signs of chronic nasolacrimal duct obstruction. Evaluation with CT is recommended. Removal of the foreign body, with dacryocystorhinstomy as needed, is curative. PMID:23719199

Lee, Lyndon B; Dutton, Jonathan J

2014-01-01

237

Sliding lipoma: an indirect inguinal hernia without a peritoneal sac.  

PubMed

With the increasing application of endoscopic hernioplasty, surgeons have now recognized that the peritoneal sac is sometimes absent in patients who present with a reducible inguinal hernia. Sliding lipoma refers to a sliding herniation of preperitoneal fat into the inguinal canal forming a reducible indirect inguinal hernia in the absence of a peritoneal sac. In this report, we describe a patient who underwent bilateral endoscopic totally extraperitoneal inguinal hernioplasty (TEP), followed by an early recurrence of left inguinal hernia, secondary to a sliding lipoma. Sliding lipoma is a challenging condition specific to endoscopic repair of inguinal hernia. All lipomas should be reduced and excised whenever feasible. Awareness and appropriate management of the sliding lipoma will help to reduce the risk of recurrence after endoscopic hernioplasty. PMID:15035847

Lau, Hung

2004-02-01

238

Oblique sectional planes of block plastinates eased by Sac Plastination.  

PubMed

To find an oblique cutting plane of a plastinate, e.g. to cut gamma-nails in the femur, the Block Plastination technique was modified. After CT and MRI examination, the specimens were plastinated with the standard resin mixture E6/E12/E600. Instead of using a box to form a block during the casting and curing stage, we embedded the specimen in a sac made of polyester foil. A polymerized wooden block was attached to the specimen. The sac was wrapped with tape to the embedded specimen with the block. This approach limited the amount of required resin to the inner volume of the plastinate. Then, the plastination sac was put in the incubator for further polymerization and curing. When the foil was removed from the plastinated specimen, the wooden block served as a socket for the grip when sawing. The outer shape of the specimen remained visible. Doing so, the adequate cutting plane could be determined easily. PMID:22209028

Kürtül, Ibrahim; Hammer, Niels; Rabi, Suganthy; Saito, Toshiyuki; Böhme, Jörg; Steinke, Hanno

2012-07-01

239

Melanoma Arising after Imiquimod Use  

PubMed Central

Imiquimod belongs to the class of 1H-imidazo-[4,5-c]quinolones—drugs originally developed as nucleoside analogues with the aim of finding new potential antiviral agents (Harrison et al., 1988). Indeed, Imiquimod was first released as treatment for genital warts before its actions against skin cancer were studied. Imiquimod is a relatively small sized molecule (Mr = 240.3) and is hydrophobic, allowing it to penetrate the skin epidermal barrier and therefore making it suitable for topical formulations (Gerster et al., 2005). Imiquimod has shown itself effective against skin cancers and precancerous lesions, especially basal cell cancers and actinic keratosis (Salasche et al., 2002, Beutner et al., 1999). There have been reports of Imiquimod being used as topical treatment against cutaneous metastases of melanoma and some authors have reported its use as first-line therapy against melanoma in situ (Smyth et al., 2011, Gagnon, 2011). We report a case of an invasive malignant melanoma arising de novo at the specific site of application of Imiquimod (Aldara cream 5%) for a biopsy-proven superficial BCC. Therefore while Imiquimod has added to our topical armamentarium against skin cancer, care must be exercised in prescribing this treatment and it is especially important to follow up patients regularly.

2014-01-01

240

5'-noncoding region sacR is the target of all identified regulation affecting the levansucrase gene in Bacillus subtilis.  

PubMed Central

The regulation of the levansucrase gene sacB was studied in Bacillus subtilis strains. Fusions were constructed in which genes of cytoplasmic proteins such as lacZ were placed immediately downstream from sacR, the regulatory region located upstream from sacB. These fusions were introduced in mutants affected in sacB regulation. In all cases the marker gene was affected in the same way as sacB by the genetic context. This result is of particular interest for the sacU pleiotropic mutations, which affect sacB expression and other cellular functions such as the synthesis of several exocellular enzymes. We also showed that strains harboring sacU+ or sacU-hyperproducing alleles contained different amounts of sacB mRNA, which was proportional to their levansucrase secretion. We concluded that the sacU gene does not affect sacB expression at the level of secretion but acts on a target within sacR. We discuss the possibility that sacU acts on a part of sacR, a homologous copy of which was found upstream from the gene of another sacU-dependent secreted enzyme of B. subtilis, beta-glucanase. Images PMID:3086292

Aymerich, S; Gonzy-Treboul, G; Steinmetz, M

1986-01-01

241

Program Options 12/11/13\\\\due.uci.edu\\due\\Files\\SAC\\CIE\\FACTSHTS\\GENINFO\\SAC Program Options with UCI Experiential Learning.pub  

E-print Network

Program Options 12/11/13\\\\due.uci.edu\\due\\Files\\SAC\\CIE\\FACTSHTS\\GENINFO\\SAC Program Options with UCI Experiential Learning.pub UCEAP Study UC Education Abroad Program UC Systemwide study abroad programs Fulfill UCI degree requirements UC credit Summer, quarter, semester, year Financial aid

Loudon, Catherine

242

Generalized Riccati Equations Arising in Stochastic Games  

E-print Network

Generalized Riccati Equations Arising in Stochastic Games Michael McAseya a Department the Riccati differential equations. The generalization involves replacing positive definite "weighting" matrices in the usual Riccati equations with either semidefinite or indefinite matrices that arise

Mou, Libin

243

Astrocytoma and Pineoblastoma Arising Sequentially in the Fourth Ventricle of the Same Patient  

Microsoft Academic Search

The sequential appearance of two different brain tumors in the same patient without intervening radiation or chemotherapy is a rare event, most often seen in hereditary cancer syndromes. We present one such case of sequential tumors, along with their molecular analysis. A 17-year-old male presented with a pilocytic astrocytoma arising in the fourth ventricle at the pontomedullary junction. Six and

Douglas L. Brockmeyer; Marion L. Walker; Greg Thompson; Daniel W. Fults

1997-01-01

244

Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa: common pathogenesis with Barrett's adenocarcinoma?  

Microsoft Academic Search

Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa is a rare tumor, with only 15 cases reported to date. We report a case in a 61-year-old man complaining of dysphagia. The upper endoscopy revealed that the tumor measured 3 cm and was 22 cm distant from the incisivors. A hiatal hernia with erosive esophagitis of the distal esophagus

Denis Chatelain; Anne-Sophie de Lajarte-Thirouard; Emmanuel Tiret; Jean-François Flejou

2002-01-01

245

A mild mutator phenotype arises in a mouse model for malignancies associated with neurofibromatosis type 1  

Microsoft Academic Search

Defects in genes that control DNA repair, proliferation, and apoptosis can increase genomic instability, and thus promote malignant progression. Although most tumors that arise in humans with neurofibromatosis type 1 (NF1) are benign, these individuals are at increased risk for malignant peripheral nerve sheath tumors (MPNST). To characterize additional mutations required for the development of MPNST from benign plexiform neurofibromas,

Rene Garza; Robert A. Hudson; C. Alex McMahan; Christi A. Walter; Kristine S. Vogel

2007-01-01

246

SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase  

PubMed Central

Background SacPox, an enzyme from the extremophilic crenarchaeal Sulfolobus acidocaldarius (Sac), was isolated by virtue of its phosphotriesterase (or paraoxonase; Pox) activity, i.e. its ability to hydrolyze the neurotoxic organophosphorus insecticides. Later on, SacPox was shown to belong to the Phosphotriesterase-Like Lactonase family that comprises natural lactonases, possibly involved in quorum sensing, and endowed with promiscuous, phosphotriesterase activity. Results Here, we present a comprehensive and broad enzymatic characterization of the natural lactonase and promiscuous organophosphorus hydrolase activities of SacPox, as well as a structural analysis using a model. Conclusion Kinetic experiments show that SacPox is a proficient lactonase, including at room temperature. Moreover, we discuss the observed differences in substrate specificity between SacPox and its closest homologues SsoPox and SisLac together with the possible structural causes for these observations. PMID:24894602

2014-01-01

247

PREPARATION OF COLLODION SACS FOR USE IN BACTERIOLOGY  

PubMed Central

A standardized method is described in detail by which collodion sacs suitable for intraperitoneal incubation and for other bacteriological experiments may be produced in large numbers, sterilized, and handled with convenience and the minimum danger of contamination. Various factors influencing permeability have been subjected to experiment. Like Brown, we found that immersion in alcohol is the most important factor, but the high permeability conferred by alcohol treatment is lost during heat sterilization if the membrane was previously allowed to dry. Quantitative experiments on the dialysis of sodium chloride, and simple tests with other substances indicate the general character of the membranes and their probable field of usefulness in bacteriology. PMID:19868478

Gates, Frederick L.

1921-01-01

248

Nouvelles propositions pour la resolution exacte du sac `a dos multi-objectif unidimensionnel en  

E-print Network

Nouvelles propositions pour la r´esolution exacte du sac `a dos multi-objectif unidimensionnel en th`ese 11 mai 2010 1 / 50 #12;Le probl`eme multi-objectif de sac `a dos 1 Le probl`eme multi-objectif de sac `a dos 2 Proc´edures en deux phases 3 Proc´edures de s´eparation et d'´evaluation 4

Paris-Sud XI, Université de

249

Mesure de la digestibilit des fourrages destins aux chevaux par la technique des sacs de nylon  

E-print Network

Mesure de la digestibilité des fourrages destinés aux chevaux par la technique des sacs de nylon selle adultes et par la technique des sacs de nylon sur 2 poneys mâles, adultes, munis d'une canule heures selon la méthode de TILLEY et TERRY (1963), puis le sac est introduit dans le caecum pour une

Boyer, Edmond

250

Identification and Characterization of Hematopoietic Stem Cells from the Yolk Sac of the Early Mouse Embryo  

Microsoft Academic Search

The yolk sac is the first site of hematopoiesis in the mammalian embryo. However, little is known about the initial stem cells in the yolk sac. We have isolated hematopoietic stem cells from early mouse embryonic yolk sac by using a sequential protocol of nonadherence to plastic, density gradient centrifugation, immunocytoadherence, and cell sorting. Isolated, nonadherent, density <1.077-g\\/cm^3, surface antigen

Hua Huang; Robert Auerbach

1993-01-01

251

Indirect inguinal hernia sac containing testis and spermatic cord in an adult patient with cryptorchidism  

PubMed Central

Sliding hernias are those in which part of the sac wall is formed by a retroperitoneal organ and/or its mesentery protruding outside the abdominal wall cavity. The hernia sac may contain jejunum, ileum, vermiform appendix, Meckel's diverticulum, stomach, ovary, fallopian tube or urinary bladder. Our report features an adult case with cryptorchidism in which testis and spermatic cord constitute a component of the indirect inguinal hernia sac. PMID:24876399

Arslan, Yusuf; Karaman, Kerem; Altintoprak, Fatih; Kahyaoglu, Zeynep; Zengin, Ismail; Uzunoglu, Mustafa Yener; Demir, Hakan

2014-01-01

252

Reliability of lead (Pb) free SAC solder interconnects with different PWB surface finishes under mechanical loading  

Microsoft Academic Search

Tin\\/silver\\/copper (SAC) solder alloys have been introduced as primary alternatives to the eutectic tin-lead solder. SAC alloys are relatively new alloy systems in packaging applications and existing studies are limited and confined mainly to the materials, assembly process, and finite element modeling. It is essential to conduct research focusing on the material aspects of the SAC alloy coupled with its

Mohammad M Hossain; Fahad Zahedi; Dereje Agonafer; S. O. Dunford; Puligandla Viswanadham

2006-01-01

253

The PIKfyve–ArPIKfyve–Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines  

SciTech Connect

Highlights: •We assess PAS complex proteins and phosphoinositide levels in breast cancer cells. •Sac3 and ArPIKfyve are markedly elevated in triple-negative breast cancer cells. •Sac3 silencing inhibits proliferation in triple-negative breast cancer cell lines. •Phosphoinositide profiles are altered in breast cancer cells. •This is the first evidence linking high Sac3 with breast cancer cell proliferation. -- Abstract: The phosphoinositide 5-kinase PIKfyve and 5-phosphatase Sac3 are scaffolded by ArPIKfyve in the PIKfyve–ArPIKfyve–Sac3 (PAS) regulatory complex to trigger a unique loop of PtdIns3P–PtdIns(3,5)P{sub 2} synthesis and turnover. Whereas the metabolizing enzymes of the other 3-phosphoinositides have already been implicated in breast cancer, the role of the PAS proteins and the PtdIns3P–PtdIns(3,5)P{sub 2} conversion is unknown. To begin elucidating their roles, in this study we monitored the endogenous levels of the PAS complex proteins in cell lines derived from hormone-receptor positive (MCF7 and T47D) or triple-negative breast cancers (TNBC) (BT20, BT549 and MDA-MB-231) as well as in MCF10A cells derived from non-tumorigenic mastectomy. We report profound upregulation of Sac3 and ArPIKfyve in the triple negative vs. hormone-sensitive breast cancer or non-tumorigenic cells, with BT cell lines showing the highest levels. siRNA-mediated knockdown of Sac3, but not that of PIKfyve, significantly inhibited proliferation of BT20 and BT549 cells. In these cells, knockdown of ArPIKfyve had only a minor effect, consistent with a primary role for Sac3 in TNBC cell proliferation. Intriguingly, steady-state levels of PtdIns(3,5)P{sub 2} in BT20 and T47D cells were similar despite the 6-fold difference in Sac3 levels between these cell lines. However, steady-state levels of PtdIns3P and PtdIns5P, both regulated by the PAS complex, were significantly reduced in BT20 vs. T47D or MCF10A cell lines, consistent with elevated Sac3 affecting directly or indirectly the homeostasis of these lipids in TNBC. Together, our results uncover an unexpected role for Sac3 phosphatase in TNBC cell proliferation. Database analyses, discussed herein, reinforce the involvement of Sac3 in breast cancer pathogenesis.

Ikonomov, Ognian C., E-mail: oikonomo@med.wayne.edu; Filios, Catherine, E-mail: cfilios@med.wayne.edu; Sbrissa, Diego, E-mail: dsbrissa@med.wayne.edu; Chen, Xuequn, E-mail: xchen@med.wayne.edu; Shisheva, Assia, E-mail: ashishev@med.wayne.edu

2013-10-18

254

Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment  

ClinicalTrials.gov

Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Metastatic Childhood Soft Tissue Sarcoma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Childhood Visual Pathway Glioma; Unspecified Childhood Solid Tumor, Protocol Specific

2013-09-27

255

Pathology of Pineal Parenchymal Tumors  

Microsoft Academic Search

Pinea l parenchymal tumors (PPTs) are neuroepithelial tumors that arise from pineocytes or their precursors. According to the currently revised WHO classification of tumors of the central nervous system, PPTs are subdivided into well-differentiated pineocytoma, poorly differentiated pineoblastoma, and PPT with intermediate differentiation (PPTID). Pineocytomas are slow-growing neoplasms composed of small mature cells resembling pineocytes. Large pineocytomatous rosettes are the

Kazufumi Sato; Toshihiko Kubota

2009-01-01

256

Recent advances in understanding the etiology and pathogenesis of pediatric germ cell tumors.  

PubMed

Pediatric germ cell tumors (GCTs) are rare neoplasms arising predominantly in the gonads and sacrococcygeal, mediastinal, and intracranial localizations. In this article, we review current knowledge of pathogenesis of pediatric GCTs, which differs from adult/adolescent GCTs. One distinctive feature is the absence of a progenitor stage, such as carcinoma in situ or gonadoblastoma, which are seen in adult/adolescent GCTs, except spermatocytic seminoma. The primordial germ cell (PGC) is the suggested origin of all GCTs, with variations in histology reflecting differentiation stage. Expression of pluripotency transcription factors OCT-3/4, NANOG, and AP-2? in germinomas/seminomas/dysgerminomas is consistent with retaining a germ cell phenotype. Teratomas, in contrast, develop through a pathway of aberrant somatic differentiation of immature germ cells, and the yolk sac tumors and choriocarcinomas result from abnormal extraembryonic differentiation. In pediatric GCTs, origin is suggested at an earlier developmental stage because of predisposing genetic factors, although responsible genes remain largely unknown. Some extragonadal GCTs have been linked to overexpression of the KIT/KITLG system, allowing for survival of aberrantly migrated ectopic PGCs. Infant gonadal/sacrococcygeal GCTs may be caused by apoptosis-related pathways, consistent with an association with polymorphisms in BAK1. Although recent advances have identified candidate pathways, further effort is needed to answer central questions of pathogenesis of these fascinating tumors. PMID:24577549

Mosbech, Christiane H; Rechnitzer, Catherine; Brok, Jesper S; Rajpert-De Meyts, Ewa; Hoei-Hansen, Christina E

2014-05-01

257

Rhabdomyosarcoma arising in a giant congenital melanocytic nevus.  

PubMed

A number of lesions have been documented to arise within congenital melanocytic nevi (CMNs). Although the most frequent malignancy arising within a CMN is melanoma, the association between rhabdomyosarcoma and CMN has rarely been documented. We present a case arising in a 4-month-old girl with a giant CMN. She presented for evaluation of a pedunculated lesion at the superior gluteal crease that had been present since birth and exhibited rapid growth. Biopsy of the lesion revealed two distinct components: an expansile proliferation of pleomorphic cells with varying degrees of cellularity and a proliferation of banal-appearing melanocytic nevic cells. The cells of the expansile proliferation displayed a wide range of morphologic features, including nests of round cells, spindle-shaped cells, and more differentiated rhabdomyoblasts within a myxoid, highly vascularized stroma. Cross-striations, a marker of skeletal muscle differentiation, were present. These tumor cells were strongly immunoreactive with desmin, myo-D1, and myogenin. Fluorescence in situ hybridization analysis with PAX3/7-FKHR probes was negative. A diagnosis of embryonal rhabdomyosarcoma in association with CMN was made. Initial excision revealed tumor at the margins, and the patient underwent reexcision with subsequent chemotherapy with vincristine, actinomycin D, and cyclophosphamide. She was disease-free at the 6-year follow-up. It has been postulated that the combination of melanocytic and rhabdomyoblastic cells within the same lesion may imply derivation from a common pluripotent stem cell or neural crest cell. Clinicians following patients with giant CMN should consider rhabdomyosarcoma in the differential diagnosis of lesions arising within the nevus. PMID:24913904

Christman, Mitalee P; Kerner, Jennifer K; Cheng, Carol; Piris, Adriano; Nepo, Anne G; Sepehr, Alireza; Kroshinsky, Daniela

2014-01-01

258

Finite Element Analysis of Stresses Developed in the Blood Sac of a Left Ventricular Assist Device  

PubMed Central

The goal of this research is to develop a 3D finite element (FE) model of a left ventricular assist device (LVAD) to predict stresses in the blood sac. The hyperelastic stress-strain curves for the segmented poly(ether polyurethane urea) blood sac were determined in both tension and compression using a servo-hydraulic testing system at various strain rates. Over the range of strain rates studied, the sac was not strain rate sensitive, however the material response was different for tension versus compression. The experimental tension and compression properties were used in a FE model that consisted of the pusher plate, blood sac and pump case. A quasi-static analysis was used to allow for nonlinearities due to contact and material deformation. The 3D FE model showed that blood sac stresses are not adversely affected by the location of the inlet and outlet ports of the device and that over the systolic ejection phase of the simulation the prediction of blood sac stresses from the full 3D model and an axisymmetric model are the same. Minimizing stresses in the blood sac will increase the longevity of the blood sac in vivo. PMID:19131267

Haut Donahue, T. L.; Dehlin, W.; Gillespie, J.; Weiss, W.J.; Rosenberg, G.

2009-01-01

259

Aneurysm sac pressure measurements after endovascular repair of abdominal aortic aneurysms  

Microsoft Academic Search

Objectives: The goal of endovascular grafting of abdominal aortic aneurysms (AAAs) is to exclude the aneurysm sac from systemic pressure and thereby decrease the risk of rupture. Unlike conventional open surgery, branch vessels in the sac (eg, lumbar artery and inferior mesenteric artery [IMA]) are not ligated and can potentially transmit pressure. The purpose of our investigation was to evaluate

Richard A. Baum; Jeffrey P. Carpenter; Constantin Cope; Michael A. Golden; Omaida C. Velazquez; David G. Neschis; Marc E. Mitchell; Clyde F. Barker; Ronald M. Fairman

2001-01-01

260

Intraembryonic, but Not Yolk Sac Hematopoietic Precursors, Isolated before Circulation, Provide Long-Term Multilineage Reconstitution  

Microsoft Academic Search

The relative contribution of yolk sac and intraembryonic precursors to hematopoiesis has been a matter of long-standing controversy. As reconstitution activity has so far only been found in embryonic tissues after the onset of circulation, the origin of reconstituting cells could not be formally established. Here, we separated yolk sac and intraembryonic splanchnopleura prior to circulation and maintained the explants

Ana Cumano; José Candido Ferraz; Michèle Klaine; James P Di Santo; Isabelle Godin

2001-01-01

261

74. SAC control center addition sect 9top three floors, first ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

74. SAC control center addition sect 9-top three floors, first floor plan, drawing number AS-BLT.AW30-02-03, dated May, 1958 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

262

84. SAC control center addition sect. 9top three floors elevations, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

84. SAC control center addition sect. 9-top three floors elevations, drawing number AS-BLT.AW30-02-03, dated 10 May, 1958 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

263

Evidence for Avian Intrathoracic Air Sacs in a New Predatory Dinosaur from Argentina  

Microsoft Academic Search

Background: Living birds possess a unique heterogeneous pulmonary system composed of a rigid, dorsally-anchored lung and several compliant air sacs that operate as bellows, driving inspired air through the lung. Evidence from the fossil record for the origin and evolution of this system is extremely limited, because lungs do not fossilize and because the bellow-like air sacs in living birds

Paul C. Sereno; Ricardo N. Martinez; Jeffrey A. Wilson; David J. Varricchio; Oscar A. Alcober; Hans C. E. Larsson

2008-01-01

264

IN VITRO/IN VIVO COMPARISON OF YOLK SAC FUNCTION AND EMBRYO DEVELOPMENT  

EPA Science Inventory

Yolk sac function and development of rat embryos grown in vitro for 24 hrs starting on day 10.5 were compared to those of embryos grown in utero. he embryos grown in vitro had significantly fewer somites, shorter crown-rump length and smaller yolk sac diameter when compared to th...

265

Infestation of the lacrimal sac by Rhinosporidium seeberi: A clinicopathological case report  

PubMed Central

Rhinosporidium seeberi, till recently known as a fungus, has been reclassified as a protistan parasite. It infects humans and many animal species. The authors describe a rare case of oculosporidiosis with involvement of the lacrimal sac exhibiting features of idiopathic orbital inflammatory disease in a young male patient. Clinical features, pathophysiology, and management of lacrimal sac rhinosporidiosis have been discussed. PMID:24212311

Mukherjee, Bipasha; Mohan, Ashwin; Sumathi, V; Biswas, Jyotirmay

2013-01-01

266

Parallel Doppler assessment of yolk sac and intervillous circulation in normal pregnancy and missed abortion  

Microsoft Academic Search

This study assessed yolk sac morphology and vascularity and intervillous blood flow in normal early pregnancy and missed abortion. Transvaginal colour and pulsed Doppler were used in a prospective analysis of 87 normal pregnancies and 48 missed abortions between 6 and 12 weeks gestation. The Kruskal-Wallis rank test was used to calculate the difference in yolk sac diameter and vascularity

A. Kurjak; S. Kupesic

1998-01-01

267

Development of the endolymphatic sac in chick embryos, with reference to the degradation of otoconia  

NASA Technical Reports Server (NTRS)

The endolymphatic sac of chick embryos (from embryonic day 7 to 1-day-old chicks) was studied light- and electron-microscopically. At stage 30-31 (embryonic day 7-7.5), the epithelial cells of the endolymphatic sac were cuboidal to columnar in shape. Microvilli were relatively well developed. The intercellular space was wide. In the endolymphatic space of the endolymphatic sac, varying shapes and sizes of otoconia-like bodies were often observed. Intracytoplasmic phagosomes containing these bodies were rarely found. After stage 37 (embryonic day 11), otoconia-like bodies in the endolymphatic sac decreased in number and size. They were almost the same as the otoconia in the macular organs, ultrastructurally. These findings indicate that the endolymphatic sac of the chick embryos may possess the function of otoconial degradation and removal of calcium from otoconia.

Yoshihara, T.; Kaname, H.; Narita, N.; Ishii, T.; Igarashi, M.; Fermin, C. D.

1992-01-01

268

Ground water in the Cul-de-Sac Plain, Haiti  

USGS Publications Warehouse

The Cul-de-Sac Plain is perhaps the most important agricultural area in Haiti because of its nearness and accessibility to Port-au-Prince, the nation's capital, metropolis, and principal seaport. Most of the agricultural produce consumed in Port-au-Prince as well as a considerable part of that exported from Haiti is grown in the plain. Because of variable and poorly distributed rainfall, high temperature, and high evaporation, semiarid climatic conditions prevail in the plain. Irrigation is, therefore, necessary for successful farming. There are no regulatory or storage facilities on the streams that enter the plain, but the mean and low-water stream flow and the discharge of springs are almost entirely appropriated for irrigation. Ground water has been utilized for irrigation to an increasing extent by the Haitian American Sugar Company, which has put down about 100 wells in the plain since 1919. Outside the existing irrigated areas of the plain are large tracts of potentially irrigable land that are uncultivated and agriculturally unproductive for lack of water. The object of the present study was to determine the possibilities of bringing these lands into cultivation by irrigation from wells. This study was part of a larger program of the Food Supply Division, Institute of Inter-American Affairs, to increase the production of food in Haiti. From September through November 1948 the senior author, a member of the U. S. Geological Survey, spent three months in the field in an investigation of the geology and ground-water resources of the Cul-de-Sac Plain. He was ably assisted by Mr. Rémy C. Lemoine, Haitian engineer-geologist, employed by the Food Supply Division. The field work included principally the geologic mapping of' the plain and the adjacent mountain borders, a ground-water inventory of existing wells and springs, and a general evaluation of significant geologic and hydrologic features.

Taylor, George C., Jr.; Lemoine, Rémy C.

1949-01-01

269

48 CFR 301.603-74 - Requirement for retention of FAC-C and HHS SAC certification.  

Code of Federal Regulations, 2011 CFR

...Requirement for retention of FAC-C and HHS SAC certification. 301.603-74 Section...Requirement for retention of FAC-C and HHS SAC certification. To maintain FAC-C...earn 80 CLPs every 2 years. To maintain HHS SAC certification, all individuals...

2011-10-01

270

Sac-1004, a novel vascular leakage blocker, enhances endothelial barrier through the cAMP/Rac/cortactin pathway  

E-print Network

Sac-1004, a novel vascular leakage blocker, enhances endothelial barrier through the c history: Received 27 April 2013 Available online 9 May 2013 Keywords: Sac-1004 Vascular permeability VEGF actin ring. Here, we developed a novel vascular leakage blocker, Sac-1004 and investigated its mechanism

Suh, Young-Ger

271

Quantification of Cardiac Sac Network Effects on a Movement-Related Parameter of Pyloric Network Output in the Lobster  

E-print Network

Quantification of Cardiac Sac Network Effects on a Movement- Related Parameter of Pyloric Network 29 September 2002 Thuma, Jeff B. and Scott L. Hooper. Quantification of cardiac sac network effects.1152/jn.00631.2002. Cardiac sac network activity (cycle period tens of seconds to minutes) has long been

Hooper, Scott

272

Molecular and Cellular Pharmacology Sac-0601 prevents retinal vascular leakage in a mouse model of diabetic retinopathy  

E-print Network

Molecular and Cellular Pharmacology Sac-0601 prevents retinal vascular leakage in a mouse model VEGF Sac-0601 Endothelium integrity is important for the normal functioning of vessels, the disruption in diabetic retinopathy, causing retinal vascular leakage. Previously, we demonstrated the ability of Sac-0601

Suh, Young-Ger

273

SIMPLIFED ACQUISITION COMMITTEE (SAC) MEETING Wednesday, April 23, 2014 -9:30 am 11:30 am  

E-print Network

SIMPLIFED ACQUISITION COMMITTEE (SAC) MEETING AGENDA Wednesday, April 23, 2014 - 9:30 am � 11:30 am to view the demonstration. Event: SAC Meeting eGOS Demonstration Event url Password: 042314 2. Closing FY as a Word file for each part. If SAC members have any comments on the HHSAR Rewrite, provide your comments

Rau, Don C.

274

TEMPERATURE EFFECTS ON GROWTH AND YOLK UTILIZATION IN YELLOWTAIL FLOUNDER, LlMANDA FERRUGINEA, YOLK-SAC LARVAE  

E-print Network

TEMPERATURE EFFECTS ON GROWTH AND YOLK UTILIZATION IN YELLOWTAIL FLOUNDER, LlMANDA FERRUGINEA, YOLK-SAC LARVAE W. HUNTTING HOWELL' ABSTRACT Embryos and yolk-sac larvae ofyellowtail flounder, Limanda ferruginea largeryolk-sac larvae at hatching tlIan those incubated at 4° and 12° C. Yolk utilization rate was positively

275

YOIK SAC STi.GgEI.MRGETICS LABVA! 0.r' TtLR.EtiiAilAIIAIi !'ISHES  

E-print Network

YOIK SAC STi.GgEI.MRGETICS o} .IiiE LABVA! 0.r' TtLR.EtiiAilAIIAIi !'ISHES A THBSIS SITBI'energeties of yoll{ sac stage larvae of c. raate, g. nicropus, and A. abclominalis were investigated und.er lab catabolic requirenents exceeded, yol}i sac caloric reserves. Each species was capable of surviving

Luther, Douglas S.

276

48 CFR 301.603-74 - Requirement for retention of FAC-C and HHS SAC certification.  

Code of Federal Regulations, 2010 CFR

...Requirement for retention of FAC-C and HHS SAC certification. 301.603-74 Section...Requirement for retention of FAC-C and HHS SAC certification. To maintain FAC-C...earn 80 CLPs every 2 years. To maintain HHS SAC certification, all individuals...

2010-10-01

277

Responses of the endolymphatic sac to perilymphatic injections and withdrawals: evidence for the presence of a one-way valve  

E-print Network

Responses of the endolymphatic sac to perilymphatic injections and withdrawals: evidence Received 16 October 2003; accepted 30 December 2003 Abstract Although the endolymphatic sac (ES) is thought and pressure changes. In a prior publication, we demonstrated changes of Kþ , Naþ and endolymphatic sac

Salt, Alec N.

278

Evidence of the Most Stretchable Egg Sac Silk Stalk, of the European Spider of the Year Meta menardi  

E-print Network

Evidence of the Most Stretchable Egg Sac Silk Stalk, of the European Spider of the Year Meta properties of stalks of silk taken from the egg sac of the cave spider Meta menardi have not yet been elongation has never been reported for egg sac silk stalks and suggests a huge unrolling microscopic

Buehler, Markus J.

279

48 CFR 301.603-74 - Requirement for retention of FAC-C and HHS SAC certification.  

Code of Federal Regulations, 2012 CFR

...Requirement for retention of FAC-C and HHS SAC certification. 301.603-74 Section...Requirement for retention of FAC-C and HHS SAC certification. To maintain FAC-C...earn 80 CLPs every 2 years. To maintain HHS SAC certification, all individuals...

2012-10-01

280

Application of the COSMO-SAC-BP Solvation Model to Predictions of Normal Boiling Temperatures for Environmentally Significant Substances  

E-print Network

Application of the COSMO-SAC-BP Solvation Model to Predictions of Normal Boiling Temperatures reported the COSMO-SAC-BP model for predicting vapor pressure and its temperature derivative, the enthalpy of vaporization. This COSMO-SAC-BP model, which contains no compound specific parameters, is based on determining

Goddard III, William A.

281

48 CFR 301.603-74 - Requirement for retention of FAC-C and HHS SAC certification.  

Code of Federal Regulations, 2013 CFR

...Requirement for retention of FAC-C and HHS SAC certification. 301.603-74 Section...Requirement for retention of FAC-C and HHS SAC certification. To maintain FAC-C...earn 80 CLPs every 2 years. To maintain HHS SAC certification, all individuals...

2013-10-01

282

Castor sacs and anal glands of the north american beaver ( Castor canadensis ): their histology, development, and relationship to scent communication  

Microsoft Academic Search

Both sexes of beavers possess a pair of castor sacs and a pair of anal glands located in paired subcutaneous cavities between the pelvis and the base of the tail. The castor sacs are not glandular in the histological sense, hence references to these structures as preputial glands or castor glands are misnomers. The wall of the castor sacs is

Jon M. Walro; Gerald E. Svendsen

1982-01-01

283

Myoepithelial carcinoma arising in recurrent pleomorphic adenoma in maxillary sinus.  

PubMed

Myoepithelial carcinoma is characterized by nearly exclusive myoepithelial differentiation and evidence of malignancy. It may arise de novo or in preexisting benign tumors including pleomorphic adenoma and benign myoepithelioma. A 39-year-old lady presented with painless progressive swelling on the right cheek and right side of palate. On surgery, there was a mass in right maxillary sinus which was surgically excised and diagnosed on histopathology as pleomorphic adenoma. Subsequently, there were two recurrences. The first recurrence was in the right maxilla after 2 years that was removed surgically and diagnosed as pleomorphic adenoma. One year later, she came with rapidly progressive swelling in bilateral cheeks and face. Intraoperatively, there was a large tumor in both maxillary sinuses with extensive local infiltration. Histologically, it was diagnosed as myoepithelial carcinoma. Carcinoma ex pleomorphic adenoma is usually a high grade malignancy. It occurs most commonly in parotid gland followed by submandibular glands, minor salivary glands and occasionally in sublingual gland. To the best of our knowledge, this is the first case of myoepithelial carcinoma arising in a recurrent pleomorphic adenoma in the maxillary sinus. PMID:24574666

Gupta, Ashumi; Manipadam, Marie Therese; Michael, Rajiv

2013-09-01

284

Myoepithelial carcinoma arising in recurrent pleomorphic adenoma in maxillary sinus  

PubMed Central

Myoepithelial carcinoma is characterized by nearly exclusive myoepithelial differentiation and evidence of malignancy. It may arise de novo or in preexisting benign tumors including pleomorphic adenoma and benign myoepithelioma. A 39-year-old lady presented with painless progressive swelling on the right cheek and right side of palate. On surgery, there was a mass in right maxillary sinus which was surgically excised and diagnosed on histopathology as pleomorphic adenoma. Subsequently, there were two recurrences. The first recurrence was in the right maxilla after 2 years that was removed surgically and diagnosed as pleomorphic adenoma. One year later, she came with rapidly progressive swelling in bilateral cheeks and face. Intraoperatively, there was a large tumor in both maxillary sinuses with extensive local infiltration. Histologically, it was diagnosed as myoepithelial carcinoma. Carcinoma ex pleomorphic adenoma is usually a high grade malignancy. It occurs most commonly in parotid gland followed by submandibular glands, minor salivary glands and occasionally in sublingual gland. To the best of our knowledge, this is the first case of myoepithelial carcinoma arising in a recurrent pleomorphic adenoma in the maxillary sinus. PMID:24574666

Gupta, Ashumi; Manipadam, Marie Therese; Michael, Rajiv

2013-01-01

285

Composite hemangioendothelioma arising from the kidney: case report with review of the literature.  

PubMed

Reported herein is a medical curiosities vascular tumor primary arising from the kidney and exhibiting unique histopathological features. A 32-year-old woman underwent a total nephrectomy of right kidney because of a mass localized in the inferior pole. Distinct from other vascular lesions, on histology the tumor had a peculiar composite pattern, consisting of benign and malignant vascular components, which were haphazardly intermixed without any definite margins. The malignant component was composed of epithelioid hemangioendothelioma (45%) and angiosarcoma (50%) with moderate differentiation. Immunohistochemically, the oval to cuboidal to spindle tumor cells expressed only endothelial markers (CD31, CD34 and factor VIII-related antigen). And the angiosarcomatous component was characterized by the presence of a greater proliferation index Ki-67. Unlike other epithelial tumors, smooth muscle actin (SMA), cytokeratin, EMA and S-100 were all negative in the epithelioid tumor cells. These findings led to the diagnosis of a low-grade vascular neoplasm with morphological features consistent with so-called composite hemangioendothelioma (CHE). At 11 month follow up the patient was alive, without evidence of tumor recurrence. CHE is an extremely rare vascular neoplasm, with borderline malignant potential, which mostly occurs in distal extremity of the limbs at the cutaneous level and, only 30 cases have been previously described until now. To our knowledge, this is the first report of CHE arising from the kidney and widens the spectrum of primary vascular tumors arising in the kidney. PMID:24040461

Zhang, Jin; Wu, Bo; Zhou, Gui-Qian; Zhang, Ru-Song; Wei, Xue; Yu, Bo; Lu, Zhen-Feng; Ma, Heng-Hui; Shi, Qun-Li; Zhou, Xiao-Jun

2013-01-01

286

Composite hemangioendothelioma arising from the kidney: case report with review of the literature  

PubMed Central

Reported herein is a medical curiosities vascular tumor primary arising from the kidney and exhibiting unique histopathological features. A 32-year-old woman underwent a total nephrectomy of right kidney because of a mass localized in the inferior pole. Distinct from other vascular lesions, on histology the tumor had a peculiar composite pattern, consisting of benign and malignant vascular components, which were haphazardly intermixed without any definite margins. The malignant component was composed of epithelioid hemangioendothelioma (45%) and angiosarcoma (50%) with moderate differentiation. Immunohistochemically, the oval to cuboidal to spindle tumor cells expressed only endothelial markers (CD31, CD34 and factor VIII-related antigen). And the angiosarcomatous component was characterized by the presence of a greater proliferation index Ki-67. Unlike other epithelial tumors, smooth muscle actin (SMA), cytokeratin, EMA and S-100 were all negative in the epithelioid tumor cells. These findings led to the diagnosis of a low-grade vascular neoplasm with morphological features consistent with so-called composite hemangioendothelioma (CHE). At 11 month follow up the patient was alive, without evidence of tumor recurrence. CHE is an extremely rare vascular neoplasm, with borderline malignant potential, which mostly occurs in distal extremity of the limbs at the cutaneous level and, only 30 cases have been previously described until now. To our knowledge, this is the first report of CHE arising from the kidney and widens the spectrum of primary vascular tumors arising in the kidney. PMID:24040461

Zhang, Jin; Wu, Bo; Zhou, Gui-Qian; Zhang, Ru-Song; Wei, Xue; Yu, Bo; Lu, Zhen-Feng; Ma, Heng-Hui; Shi, Qun-Li; Zhou, Xiao-Jun

2013-01-01

287

The First Transmembrane Domain of Lipid Phosphatase SAC1 Promotes Golgi Localization  

PubMed Central

The lipid phosphatase Sac1 cycles between endoplasmic reticulum and cisternal Golgi compartments. In proliferating mammalian cells, a canonical dilysine motif at the C-terminus of Sac1 is required for coatomer complex-I (COP-I)-binding and continuous retrieval to the ER. Starvation triggers accumulation of Sac1 at the Golgi. The mechanism responsible for Golgi retention of Sac1 is unknown. Here we show that the first of the two transmembrane regions in human SAC1 (TM1) functions in Golgi localization. A minimal construct containing only TM1 and the adjacent flanking sequences is concentrated at the Golgi. Transplanting TM1 into transferrin receptor 2 (TfR2) induces Golgi accumulation of this normally plasma membrane and endosomal protein, indicating that TM1 is sufficient for Golgi localization. In addition, we determined that the N-terminal cytoplasmic domain of SAC1 also promotes Golgi localization, even when TM1 is mutated or absent. We conclude that the distribution of SAC1 within the Golgi is controlled via both passive membrane thickness-dependent partitioning of TM1 and a retention mechanism that requires the N-terminal cytoplasmic region. PMID:23936490

Wang, Jinzhi; Chen, Juxing; Enns, Caroline A.; Mayinger, Peter

2013-01-01

288

Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function  

PubMed Central

Sac family phosphoinositide (PI) phosphatases are an essential family of CX5R(T/S)-based enzymes, involved in numerous aspects of cellular function such as PI homeostasis, cellular signalling, and membrane trafficking. Genetic deletions of several Sac family members result in lethality in animal models and mutations of the Sac3 gene have been found in human hereditary diseases. In this study, we report the crystal structure of a founding member of this family, the Sac phosphatase domain of yeast Sac1. The 2.0 Å resolution structure shows that the Sac domain comprises of two closely packed sub-domains, a novel N-terminal sub-domain and the PI phosphatase catalytic sub-domain. The structure further shows a striking conformation of the catalytic P-loop and a large positively charged groove at the catalytic site. These findings suggest an unusual mechanism for its dephosphorylation function. Homology structural modeling of human Fig4/Sac3 allows the mapping of several disease-related mutations and provides a framework for the understanding of the molecular mechanisms of human diseases. PMID:20389282

Manford, Andrew; Xia, Tian; Saxena, Ajay Kumar; Stefan, Christopher; Hu, Fenghua; Emr, Scott D; Mao, Yuxin

2010-01-01

289

Guidance in vitro of the pollen tube to the naked embryo sac of torenia fournieri  

PubMed Central

The precise guidance of the pollen tube to the embryo sac is critical to the successful sexual reproduction of flowering plants. We demonstrate here the guidance of the pollen tube to the embryo sac in vitro by using the naked embryo sac of Torenia fournieri, which protrudes from the micropyle of the ovule. We developed a medium for culture of both the ovule and the pollen tube of T. fournieri and cocultivated them in a thin layer of solid medium. Although pollen tubes that had germinated in vitro passed naked embryo sacs, some pollen tubes that grew semi-in vitro through a cut style arrived precisely at the site of entry into the embryo sac, namely, the filiform apparatus of the synergids. When pollen tubes were unable to enter the embryo sac, they continuously grew toward the same filiform apparatus, forming narrow coils. Pollen tubes selectively arrived at complete, unfertilized embryo sacs but did not arrive at those of heat-treated ovules or those with disrupted synergids. These results convincingly demonstrate that pollen tubes are specifically attracted to the region of the filiform apparatus of living synergids in vitro. PMID:9836742

Higashiyama, T; Kuroiwa, H; Kawano, S; Kuroiwa, T

1998-01-01

290

The pathology of late recurrence of testicular germ cell tumors.  

PubMed

A total of 91 men had histologically documented late recurrences of testicular germ cell tumors characterized by a complete response to treatment with a subsequent disease-free interval of at least 2 years and no evidence of a second primary lesion. Ninety percent of the patients for whom information was available received chemotherapy shortly after their initial diagnosis of testicular germ cell tumors; most of the other patients were known to have stage I disease initially. Overall, 60% of patients had teratoma in their late recurrences, including 20 patients (22%) in whom teratoma was the only element. Thus, teratoma was the most common type of neoplasm in late recurrences. Excluding teratoma coexisting with other types of neoplasms, yolk sac tumor was the most frequent type of tumor in patients with late recurrence. It occurred in 47% of patients, either alone or with teratoma, another nonteratomatous germ cell tumor type, or a "nongerm cell malignant tumor." Unusual types of yolk sac tumor, including glandular, parietal, clear cell, and pleomorphic patterns, were seen frequently in late recurrences and often raised differential diagnostic problems with "nongerm cell" carcinomas. A smaller number of late recurrences consisted of other types of neoplasms. Twenty percent of patients with late recurrence had a nonteratomatous germ cell tumor other than yolk sac tumor, either alone, with yolk sac tumor, or with a "nongerm cell malignant tumor." Most of these nonteratomatous germ cell tumors other than yolk sac tumor were embryonal carcinoma, although rarely seminoma and choriocarcinoma were encountered. "Nongerm cell malignant tumors," including both sarcomas and carcinomas of various types, occurred in 23% of late-recurrence patients, either alone or with a nonteratomatous germ cell tumor. Late recurrences were seen in many different sites in these patients, including the retroperitoneum, abdomen, pelvis, liver, mediastinum, lung, bone (femur, vertebra, and rib), lymph nodes outside the retroperitoneum and mediastinum (supraclavicular, neck, and axillary regions), scrotum and inguinal regions, adrenal gland, chest wall, and buttocks. Follow-up data were available for 79 of the 91 patients studied. Duration of follow-up ranged from 2 months to 13 years after the patient's first late recurrences; the mean length of follow-up was 4.8 years. Patients whose late recurrences consisted of teratoma only had the most favorable outcomes, with 79% having no evidence of disease at last follow-up. Patients whose late recurrences consisted of pure "nongerm cell malignant tumor" or pure germ cell tumor (yolk sac tumor or other types) had a much worse prognosis: Only 36% to 37% were alive with no evidence of disease. Patients with two different types of nonteratomatous malignancies in their late recurrences had a dismal clinical course: Only 17% with both yolk sac tumor and other nonteratomatous germ cell tumor had no evidence of disease, whereas no patient with both nonteratomatous germ cell tumor and "nongerm cell malignant tumor" was disease free. Late recurrences consisting of teratoma alone often have a favorable outcome, but the prognosis in all other patients is poor. Furthermore, late recurrence is not likely to respond to chemotherapy and is best treated by surgical excision when possible. PMID:10680894

Michael, H; Lucia, J; Foster, R S; Ulbright, T M

2000-02-01

291

Surveillance Analysis Computer System (SACS): Software requirements specification (SRS). Revision 2  

SciTech Connect

This document is the primary document establishing requirements for the Surveillance Analysis Computer System (SACS) database, an Impact Level 3Q system. SACS stores information on tank temperatures, surface levels, and interstitial liquid levels. This information is retrieved by the customer through a PC-based interface and is then available to a number of other software tools. The software requirements specification (SRS) describes the system requirements for the SACS Project, and follows the Standard Engineering Practices (WHC-CM-6-1), Software Practices (WHC-CM-3-10) and Quality Assurance (WHC-CM-4-2, QR 19.0) policies.

Glasscock, J.A.

1995-03-08

292

Pancreatic neuroendocrine tumors.  

PubMed

Pancreatic neuroendocrine tumors (pancreatic NETs) are rare, low- to intermediate-grade neoplasms thought to arise from the pancreatic islets. Recent advances in pathology and our understanding of the biological behavior of this group of tumors has resulted in changes in their nomenclature and how we treat them. This review puts into perspective our current understanding of pancreatic NETs in terms of their incidence, pathology, and management. PMID:23054950

Shrikhande, Shailesh V; Sirohi, Bhawna; Goel, Mahesh; Barreto, Savio G

2013-01-01

293

Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis.  

PubMed

The enucleated definitive erythrocytes of mammals are unique in the animal kingdom. The observation that yolk sac-derived primitive erythroid cells in mammals circulate as nucleated cells has led to the conjecture that they are related to the red cells of fish, amphibians, and birds that remain nucleated throughout their life span. In mice, primitive red cells express both embryonic and adult hemoglobins, whereas definitive erythroblasts accumulate only adult hemoglobins. We investigated the terminal differentiation of murine primitive red cells with use of antibodies raised to embryonic beta H1-globin. Primitive erythroblasts progressively enucleate between embryonic days 12.5 and 16.5, generating mature primitive erythrocytes that are similar in size to their nucleated counterparts. These enucleated primitive erythrocytes circulate as late as 5 days after birth. The enucleation of primitive red cells in the mouse embryo has not previously been well recognized because it coincides with the emergence of exponentially expanding numbers of definitive erythrocytes from the fetal liver. Our studies establish a new paradigm in the understanding of primitive erythropoiesis and support the concept that primitive erythropoiesis in mice shares many similarities with definitive erythropoiesis of mammals. PMID:15031208

Kingsley, Paul D; Malik, Jeffrey; Fantauzzo, Katherine A; Palis, James

2004-07-01

294

SAC-B GaAs solar array  

NASA Astrophysics Data System (ADS)

This paper describes the electrical and mechanical design of the GaAs solar array of SAC-B, an Argentinian scientific satellite, planned for launch in 1995 into a 550-km circular orbit by Pegasus vehicle. The solar array is made up of four deployable wings, embodying approximately 1000 LPE GaAs solar cells, (30 x 41 sq mm), capable of providing about 215 W at 28 V at EOL. The mechanical structure of each panel comprises an aluminum honeycomb structure with carbon fiber skins; the active facesheet is covered with an insulating layer of kapton/fiberglass. Each panel is attached via a pair of hinges to the spacecraft body while a restraint/release mechanism holds the other panel edge to the spacecraft. Different considerations have been taken into account for the electrical and mechanical design of the solar array: geometrical constraints of the Pegasus static envelope and the satellite for the panel dimensioning, mission degradation factors, minimization of the magnetic moment, and realiability requirements. Several environmental tests (including thermal vacuum and vibration) are foreseen at panel and/or satellite level to verify performances during the mission.

Brambilla, L.; Caon, A.; Contini, R.; D'Accolti, G.; Rossi, E.; Verzeni, G.; Flores, C.; Paletta, F.; Pedrazzoli, G.; Grattarola, M.

1993-10-01

295

Warthin Tumor of the Upper Lip: An Unusual Location of a Benign Salivary Gland Tumor  

Microsoft Academic Search

Warthin tumor (papillary cystadenoma lymphomatosum) is a benign salivary gland tumor involving almost exclusively the parotid gland. The lip is a very unusual location for this type of tumor, which develops only rarely in minor salivary glands. The case of 42-year-old woman with Warthin tumor arising in minor salivary glands of the upper lip is reported.

Aroldo dos Santos Almeida; João Adolfo Costa Hanemann; Denise Tostes Oliveira

2011-01-01

296

Molecular characterization of oct4-expressing yolk sac endoderm stem cell lines.  

E-print Network

The extraembryonic endoderm (XEN) defines the yolk sac, a set of membranes that provide essential support for mammalian embryos. Recently, the committed XENprecursor was identified in the embryonic Inner Cell Mass (ICM) as a group of cells...

Debeb, Bisrat Godefay

2009-05-15

297

Histological evaluation of pearl-sac development in the Concho Pearly Mussel (Cyrtonaias tampicoens)  

E-print Network

The purpose of this project was to assess the wound repair properties and epithelial cell proliferation in the processes necessary to develop a pearl-sac in the mantle of the Concho Pearly Mussel (Uniodidea: Cyrtonaias tampicoens). Samples...

Tower, Stephan N.

2012-06-07

298

38 CFR Appendix A to Part 41 - Data Collection Form (Form SF-SAC)  

Code of Federal Regulations, 2010 CFR

...SF-SAC and instructions for its completion may be obtained from the following Web page: http://harvester.census.gov/fac/collect/sfsac_01.pdf . It is also available from the address provided in §...

2010-07-01

299

Cotton embryogenesis: The entrance and discharge of the pollen tube in the embryo sac  

Microsoft Academic Search

An analysis of the entrance and discharge of the pollen tube into the embryo sac of Gossypium hirsutum was made with the light and electron microscopes. The following sequence of events is seen in cotton:

William A. Jensen; Donald B. Fisher

1967-01-01

300

Performance Evaluation of Hybrid SCM/SAC-OCDMA Transmissions System using Dynamic Cyclic Shift Code  

NASA Astrophysics Data System (ADS)

In this paper, the performance of a hybrid scheme of Subcarrier Multiplexing (SCM) technique in a Spectral Amplitude Coding (SAC) Optical Code Division Multiple Access (CDMA) transmissions system is evaluated. The hybrid system is design using new code family; we call it Dynamic Cyclic Shift (DCS) code. The DCS code design for SAC-OCDMA system to reduce the effect of Multi Access Interference due to it property of low cross-correlation (?C ? 1) between code words. In contrast, the SCM scheme shows the ability to increase the data rate of SAC-OCDMA system. Consequently, the hybrid SCM/SAC-OCDMA system could be one promising solution to the high-capacity access network with low cost effective, good flexibility and enhanced security, which makes an attractive candidate for next-generation broadband access network.

Abd, Thanaa Hussein; Aljunid, S. A.; Fadhil, Hilal Adnan; Radhi, Ibrahim Fadhil; Saad, N. M.

2012-12-01

301

Endometrial carcinoma arising in a bicornuate uterus  

PubMed Central

Endometrial carcinomas arising in a bicornuate uterus are rare, only five case of which have been previously reported. We present a case of endometrial cancer arising in a bicornuate uterus, occurring in a 65-year-old woman. Unlike previously reported cases, our case showed mixed endometrial adenocarcinoma and undifferentiated carcinoma in one horn and focal adenocarcinoma in the other. Adequate tissue sampling of both horns is necessary for accurate diagnosis of malignancy in patients with a bicornuate uterus. Physicians should be aware of the possibility of this abnormality in cases when endometrial cancer is suspected but histology fails to confirm. PMID:25264532

Munkhdelger, Jijgee; Mia-Jan, Khalilullah; Cha, Dong Soo

2014-01-01

302

Evidence for Avian Intrathoracic Air Sacs in a New Predatory Dinosaur from Argentina  

PubMed Central

Background Living birds possess a unique heterogeneous pulmonary system composed of a rigid, dorsally-anchored lung and several compliant air sacs that operate as bellows, driving inspired air through the lung. Evidence from the fossil record for the origin and evolution of this system is extremely limited, because lungs do not fossilize and because the bellow-like air sacs in living birds only rarely penetrate (pneumatize) skeletal bone and thus leave a record of their presence. Methodology/Principal Findings We describe a new predatory dinosaur from Upper Cretaceous rocks in Argentina, Aerosteon riocoloradensis gen. et sp. nov., that exhibits extreme pneumatization of skeletal bone, including pneumatic hollowing of the furcula and ilium. In living birds, these two bones are pneumatized by diverticulae of air sacs (clavicular, abdominal) that are involved in pulmonary ventilation. We also describe several pneumatized gastralia (“stomach ribs”), which suggest that diverticulae of the air sac system were present in surface tissues of the thorax. Conclusions/Significance We present a four-phase model for the evolution of avian air sacs and costosternal-driven lung ventilation based on the known fossil record of theropod dinosaurs and osteological correlates in extant birds: (1)?Phase I—Elaboration of paraxial cervical air sacs in basal theropods no later than the earliest Late Triassic. (2)?Phase II—Differentiation of avian ventilatory air sacs, including both cranial (clavicular air sac) and caudal (abdominal air sac) divisions, in basal tetanurans during the Jurassic. A heterogeneous respiratory tract with compliant air sacs, in turn, suggests the presence of rigid, dorsally attached lungs with flow-through ventilation. (3)?Phase III—Evolution of a primitive costosternal pump in maniraptoriform theropods before the close of the Jurassic. (4)?Phase IV—Evolution of an advanced costosternal pump in maniraptoran theropods before the close of the Jurassic. In addition, we conclude: (5)?The advent of avian unidirectional lung ventilation is not possible to pinpoint, as osteological correlates have yet to be identified for uni- or bidirectional lung ventilation. (6)?The origin and evolution of avian air sacs may have been driven by one or more of the following three factors: flow-through lung ventilation, locomotory balance, and/or thermal regulation. PMID:18825273

Sereno, Paul C.; Martinez, Ricardo N.; Wilson, Jeffrey A.; Varricchio, David J.; Alcober, Oscar A.; Larsson, Hans C. E.

2008-01-01

303

Testosterone sensitivity of the seminal sacs of tree sparrows (Spizella arborea) in different reproductive states.  

PubMed

Testosterone sensitivity of the seminal sacs of castrated tree sparrows from each of three reproductive states was evaluated by measuring the change in seminal-sac mass per unit change in the logarithm of replacement or plasma testosterone. Birds were exposed to exogenous testosterone for 38 days. Replacement doses less than 0.17 mumol or plasma concentrations less than about 0.7 nmol/l did not induce seminal-sac growth in photosensitive castrated birds held on short days, in photosensitive castrated birds transferred from short to long days, or in photorefractory castrated birds retained on long days. Higher replacement doses or plasma concentrations, however, stimulated log dose-dependent growth of the seminal sacs in castrated birds from all three reproductive states. The change in seminal-sac mass per unit change in the logarithm of the dose of replacement testosterone was less (P = 0.0495) in photosensitive castrated birds held on short days than in photosensitive castrated birds transferred to long days. A more critical test of sensitivity (i.e. the change in seminal-sac mass per unit change in the logarithm of mean plasma testosterone concentration) indicated, however, that sensitivity of the seminal sacs to testosterone is independent of reproductive state. That result, when considered in the context of the plasma testosterone profile of intact males during a simulated reproductive cycle, argues that the seminal sacs of sexually quiescent (photosensitive or photorefractory) tree sparrows are small not because of their insensitivity to androgens, but because of a deficiency of circulating androgens. PMID:3701240

Wilson, F E

1986-04-01

304

Deposition of anal-sac secretions by captive wolves (Canis lupus)  

USGS Publications Warehouse

Deposition of anal-sac secretions by captive wolves was investigated by a labelling technique using protein-bound iodine125 and food dye. Wolves deposited secretions on some but not all scats. Adult males, especially the alpha male, deposited anal-sac secretions more frequently while defecating than did females or juveniles. Secretions sometimes also were deposited independently of defecation, suggesting a dual role in communication by these substances.

Asa, C.S.; Peterson, E.K.; Seal, U.S.; Mech, L.D.

1985-01-01

305

Social Cohesiveness, Territoriality, and Holiday DecorationsThe Influence of Cul-de-Sacs  

Microsoft Academic Search

Altman's territoriality theory was used as a framework for examining neighborhood attachment. We hypothesized that attachment would be manifested in interrelated patterns of neighboring behaviors, attitudes indicating that the block was a secondary territory, and individual and communal displays of holiday decorations. Design features of cul-de-sacs were hypothesized to contribute to greater degrees of block attachment on cul-de-sacs than on

Barbara B. Brown; Carol M. Werner

1985-01-01

306

Characterization of Definitive Lymphohematopoietic Stem Cells in the Day 9 Murine Yolk Sac  

Microsoft Academic Search

The site of origin of lymphohematopoietic stem cells (HSC) that initiate definitive blood cell production in the murine fetal liver is controversial. Contrary to reports that the preliver yolk sac does not contain definitive HSC, we observed that CD34+ day 9 yolk sac cells repopulated multiple blood cell lineages in newborn hosts for at least 1 year. Furthermore, 100 CD34+c-Kit+

Mervin C Yoder; Kelly Hiatt; Parmesh Dutt; Pinku Mukherjee; David M Bodine; Donald Orlic

1997-01-01

307

Unusual microtubular cytoskeleton of apomictic embryo sac of Chondrilla juncea L  

Microsoft Academic Search

Summary.  The mature apomictic embryo sac of Chondrilla juncea is highly vacuolated and demonstrates a polarization similar to that of the amphimictic gametophyte. The microtubule cytoskeleton\\u000a of this embryo sac is uncharacteristic and relatively weak. The microtubules are positioned along cell walls and resemble\\u000a cortical microtubules of somatic cells. They do not form the parallel, brushlike structures observed around the filiform

M. Ko?ci?ska-Paj?k; J. Bednara

2006-01-01

308

Radioisotopes: Problems of Responsibility Arising from Medicine.  

National Technical Information Service (NTIS)

Radioisotopes have brought about great progress in the battle against illnesses of mainly tumoral origin, whether in diagnosis (nuclear medicine) or in treatment (medical radiotherapy). They are important enough therefore to warrant investigation. Such a ...

M. Dupon

1978-01-01

309

Acoustic analysis of primate air sacs and their effect on vocalization.  

PubMed

This paper presents an analysis of the acoustic impedance of primate air sacs and their interaction with the vocal tract. A lumped element model is derived and it is found that the inertance of the neck and the volume of the air sac are relevant, as well as the mass and stiffness of the walls (depending on the tissue). It is also shown that at low frequencies, radiation from the air sac can be non-negligible, even if the mouth is open. It is furthermore shown that an air sac can add one or two low resonances to the resonances of the oral tract, and that it shifts up the oral tract's resonances below approximately 2000 Hz, and shifts them closer together. The theory was verified by acoustic measurements and applied to the red howler monkey (Alouatta seniculus) and the siamang (Symphalangus syndactylus). The theory describes the physical models and the siamang calls correctly, but appears incomplete for the howler monkey vocalizations. The relation between air sacs and the evolution of speech is discussed briefly, and it is proposed that an air sac would reduce the ability to produce distinctive speech, but would enhance the impression of size of the vocalizer. PMID:20000947

de Boer, Bart

2009-12-01

310

ARISE: American renaissance in science education  

SciTech Connect

The national standards and state derivatives must be reinforced by models of curricular reform. In this paper, ARISE presents one model based on a set of principles--coherence, integration of the sciences, movement from concrete ideas to abstract ones, inquiry, connection and application, sequencing that is responsive to how people learn.

NONE

1998-09-14

311

Askin's Tumor: A Dual Case Study  

PubMed Central

Askin's tumor is a rare tumor arising from the chest wall. It is a subset of Ewing sarcoma characterized histologically by the presence of small round blue cells. It is a highly malignant tumor with guarded prognosis, which is dependent upon the extension of tumor at the time of diagnosis. A dual paper of Askin's tumors in young boys is being presented here. PMID:21792357

Shrestha, Bikash; Kapur, Bhupendra Nath; Karmacharya, Kavita; Kakkar, Sunita; Ghuliani, Ranjit

2011-01-01

312

Clear Cell Adenocarcinoma Arising from Abdominal Wall Endometriosis  

PubMed Central

Endometriosis is a frequent benign disorder. Malignancy arising in extraovarian endometriosis is a rare event. A 49-year-old woman is presented with a large painful abdominal wall mass. She underwent a myomectomy, 20 years before, for uterus leiomyoma. Computed tomography suggested that this was a desmoid tumor and she underwent surgery. Histological examination showed a clear cell adenocarcinoma associated with endometriosis foci. Pelvic ultrasound, computed tomography, and endometrial curettage did not show any malignancy or endometriosis in the uterus and ovaries. Adjuvant chemotherapy was recommended, but the patient was lost to follow up. Six months later, she returned with a recurrence of the abdominal wall mass. She was given chemotherapy and then she was reoperated. PMID:19266089

Achach, Thouraya; Rammeh, Soumaya; Trabelsi, Amel; Ltaief, Rached; Ben Abdelkrim, Soumaya; Mokni, Moncef; Korbi, Sadok

2008-01-01

313

Breaking the tolerance for tumor  

PubMed Central

Tumors arise and progress in immunocompetent hosts presumably by activating tolerance mechanisms critical for normal homeostasis. Host immune cells can mount anti-tumor responses by activation of Toll-like receptors (TLRs). However, emerging data suggests that molecules that negatively regulate TLRs are exploited by tumors to induce tolerance and mitigate the host immunosurveillance. Targeting these negative regulators can be a potential new immunotherapeutic strategy. PMID:22737610

Standiford, Theodore J.; Keshamouni, Venkateshwar G.

2012-01-01

314

CT and MR imaging findings of palatal tumors.  

PubMed

Palatal tumors commonly arise from the minor salivary glands, and benign tumors account for approximately half of all minor salivary gland tumors. Minor salivary gland tumors have an affinity for the posterior hard palate and soft palate and virtually never arise in the midline, probably because of the distribution of palatal salivary glands. The majority of benign salivary gland tumors of the palate are pleomorphic adenomas, while the most common malignant salivary gland tumor is adenoid cystic carcinoma, followed by mucoepidermoid carcinoma, adenocarcinoma, and polymorphous low-grade adenocarcinoma. Epithelial tumors frequently arise from the soft palate. The majority of benign epithelial tumors of the palate are papillomas, while most malignant epithelial tumors are squamous cell carcinomas. Various types of mesenchymal tumors, including fibromas, lipomas, schwannomas, neurofibromas, hemangiomas, and lymphangiomas, also involve the palate. This article describes the CT and MR findings of benign and malignant palatal tumors. PMID:24377674

Kato, Hiroki; Kanematsu, Masayuki; Makita, Hiroki; Kato, Keizo; Hatakeyama, Daijiro; Shibata, Toshiyuki; Mizuta, Keisuke; Aoki, Mitsuhiro

2014-03-01

315

Saccharinato complexes of Ce(V) with 2-hydroxypyridine: synthesis, spectroscopic and thermal characteristics of [Ce(sac)2(SO4)(H2O)4] and [Ce(sac)2(SO4)(PyOH)2].  

PubMed

The synthesis of Ce(IV) complexes [Ce(sac)2(SO4)(H2O)4] (1) and [Ce(sac)2 (SO4)(PyOH)2] (2) (sac=saccharinate, PyOH=2-hydroxypyridine) starting with sodium saccharinate is described. Their vibrational and nuclear magnetic resonance (1H, 13C) spectra as well as their thermal mode of degradation were investigated. The data indicate that sac in complex 1 behaves as a monodentate ligand through the nitrogen atoms. Saccharinato ligand in complex 2 shows different mode of coordination, where it behaves as tridentate and binds Ce(IV) through its carbonylic oxygen, nitrogen and sulphonylic oxygen atoms. The most probable structure in complex 2 is that, units of [Ce(sac)2(SO4)(PyOH)2] are linked by bridges of the O- of sac sulphonyl leading to polymeric chains. PMID:18077205

Gaballa, Akmal S; Teleb, Said M; Müller, Thomas

2008-10-01

316

Alveolar sacs and the expirograms of He and SF6: a model study.  

PubMed

In 1975, Hansen and Ampaya described alveolated outpouchings in the walls of the acinar ducts, which were observed in all airway generations within the acini. These structures were called alveolar sacs, and they appear to contain the larger fraction (56%) of the acinar volume. The total depth of an alveolar sac including its alveoli (approximately 0.32 mm) is comparable to the mean length of an acinar duct (0.18 to 0.97 mm). Therefore, the alveolar sacs contribute to the asymmetric morphology of the acini. In this paper we investigate the impact of this aspect of the alveolar sacs on the shape of the expirograms of He and SF6. To that end, single-breath washout experiments were simulated with two different mathematical lung models. The one model is an airway model in which the alveolar sacs are modelled explicitly by separate compartments. The expirograms obtained with this model are compared to those obtained with a conventional axisymmetric airway model which is used as a reference model. In this model the volumes of the alveolar sacs are added to those of the acinar ducts; i.e., both air spaces are represented by the same compartments. The washout of He and SF6 was simulated for three different breathing maneuvers corresponding to ventilatory conditions at rest and at exercise. Comparison of the expirograms obtained with the two models showed no differences between their shapes when identical dimensions are used for the lengths and cross sections of the alveolar ducts in the two models. We conclude that the contribution of the alveolar sacs to the asymmetric morphologic structure of the acini has no consequences for the shape of the expirograms of He and SF6. PMID:1889200

Six, D P; de Vries, W R; Luijendijk, S C

1991-08-01

317

Goals of the ARISE Space VLBI Mission  

E-print Network

Supermassive black holes, with masses of 10^6 to more than 10^9 solar masses, are among the most spectacular objects in the Universe, and are laboratories for physics in extreme conditions. The primary goal of ARISE (Advanced Radio Interferometry between Space and Earth) is to use the technique of Space VLBI to increase our understanding of black holes and their environments, by imaging the havoc produced in the near vicinity of the black holes by their enormous gravitational fields. The mission will be based on a 25-meter space-borne radio telescope operating at frequencies between 8 and 86 GHz, roughly equivalent to an orbiting element of the Very Long Baseline Array. In an elliptical orbit with an apogee height of 40,000-100,000 km, ARISE will provide resolution of 15 microarcseconds or better, 5-10 times better than that achievable on the ground. At frequencies of 43 and 86 GHz, the resolution of light weeks to light months in distant quasars will complement the gamma-ray and X-ray observations of high-energy photons, which come from the same regions near the massive black holes. At 22 GHz, ARISE will image the water maser disks in active galaxies more than 15 Mpc from Earth, probing accretion physics and giving accurate measurements of black-hole masses. ARISE also will study gravitational lenses at resolutions of tens of microarcseconds, yielding important information on the dark-matter distribution and on the possible existence of compact objects with masses of 10^3 to 10^6 solar masses.

James S. Ulvestad

1999-01-26

318

Malignant Peripheral Nerve Sheath Tumor: An Unusual Cause of Intussusception  

Microsoft Academic Search

Malignant peripheral nerve sheath tumors (MPNST) are defined as any tumor arising from a peripheral nerve or showing nerve\\u000a sheath differentiation. The majority of these tumors arise on the trunk, extremities, or head and neck region. The literature\\u000a to date has fewer than 14 cases of MPNST arising in the gastrointestinal tract, and only two cases were ever reported in

Dana A. Telem; David Pertsemlidis

2008-01-01

319

Figure 3: Stress vs. Strain curve for Bulk SAC305 0 0.2 0.4 0.6  

E-print Network

Figure 3: Stress vs. Strain curve for Bulk SAC305 0 10 20 30 40 50 0 0.2 0.4 0.6 Stress(MPa) Strain (mm/mm) Effect of Various Operating Conditions on the Low Cycle Fatigue of Bulk SAC 305 Solder Eric important to integrate lead-free solder, such as SAC 305 (96.5 % Sn by weight, 3.0% Cu, 0.5% Ag) · Bulk

Bernstein, Joseph B.

320

Reprsentation compacte des sacs de mots pour l'indexation d'images Herv Jgou Matthijs Douze Cordelia Schmid  

E-print Network

Représentation compacte des sacs de mots pour l'indexation d'images Hervé Jégou Matthijs Douze limitations est la quantité de mémoire requise pour décrire chaque image. Une représentation de type sac de article, nous étudions la possibilité de compres- ser et indexer conjointement les représentations sacs de

Paris-Sud XI, Université de

321

The Sac domain-containing phosphoinositide phosphatases: structure, function, and disease  

PubMed Central

Phosphoinositides (PIs) have long been known to have an essential role in cell physiology. Their intracellular localization and concentration must be tightly regulated for their proper function. This spatial and temporal regulation is achieved by a large number of PI kinases and phosphatases that are present throughout eukaryotic species. One family of these enzymes contains a conserved PI phosphatase domain termed Sac. Although the Sac domain is homologous among different Sac domain-containing proteins, all appear to exhibit varied substrate specificity and subcellular localization. Dysfunctions in several members of this family are implicated in a range of human diseases such as cardiac hypertrophy, bipolar disorder, Down’s syndrome, Charcot-Marie-Tooth disease (CMT) and Amyotrophic Lateral Sclerosis (ALS). In plant, several Sac domain-containing proteins have been implicated in the stress response, chloroplast function and polarized secretion. In this review, we focus on recent findings in the family of Sac domain-containing PI phosphatases in yeast, mammal and plant, including the structural analysis into the mechanism of enzymatic activity, cellular functions, and their roles in disease pathophysiology. PMID:24860601

HSU, FoSheng; MAO, Yuxin

2014-01-01

322

Failure of zinc to prevent dysmorphogenesis of cultured rat conceptuses by anti-yolk sac antiserum  

SciTech Connect

Day 10 rat conceptuses were cultured for 48h in the presence of either cadmium or anti-vesceral yolk sac antiserum (AVYS). Cadmium was embryotoxic at concentrations exceeding 0.25 ug/ml while AVYS caused embryonic dysmorphogenesis, particularly affecting the optic vesicles, at concentrations of 2 ul/ml and above. The effect of pretreatment with zinc on embryotoxicity caused by cadmium or AVYS was studied. Zinc ameliorated the effects of cadmium but had no effect on AVYS-induced embryonic abnormalities. In a second set of experiments inhibition of /sup 125/I-labelled PVP uptake by the yolk sac of cultured whole conceptuses was studied. Cadmium and AVYS both inhibited uptake compared to control cultures. Zinc again ameliorated the effect of cadmium but had no action against AVYS-induced inhibition. These results are in contrast to their previous findings using isolated cultured yolk sacs in which zinc ameliorated the inhibitory effects on /sup 125/I-labelled PVP uptake of both cadmium and AVYS. These data show that in experiments using the isolated cultured yolk sac and the intact cultured conceptus, a qualitatively different response in yolk sac behavior is observed under similar experimental conditions.

Marlow, R.; Freeman, S.J.

1989-01-01

323

Respiratory responses of domestic fowl to hyperthermia following selective air sac occlusions.  

PubMed

Ventilation together with blood and respiratory gas tensions were measured in adult domestic fowl under normothermic and hyperthermic conditions, following bilateral occlusion of the cranial and caudal thoracic air sacs (series I) or the cranial and caudal thoracic plus the abdominal air sacs (series II). Series I birds showed no significant differences from controls. Both control and experimental animals displayed a typical thermal polypnoea combined with mild hypocapnaemia. A larger drop in PCO2 was demonstrated in the clavicular sac than in the blood, possibly indicating partial failure of inspiratory valving at the ventrobronchi. However, there was no evidence of any effect of thoracic air sac occlusion on inspiratory airflow valving in the palaeopulmo. Series II birds were strongly hypercapnaemic/hypoxaemic in normothermic conditions, with a normal minute volume, but a faster, shallower breathing pattern. During hyperthermia they increased minute ventilation 3-fold, as in control animals, and blood gas tensions were almost restored to normal. Again, there was no evidence that experimental reduction in air sac capacity, in this case up to 70% of the total, had any effect on inspiratory airflow valving in the palaeopulmo, although inevitably in this case airflow in the neopulmo was abolished. PMID:2112403

Brackenbury, J H; Amaku, J A

1990-05-01

324

A status report on the development of SAC2000: A new seismic analysis code  

SciTech Connect

We are developing a new Seismic Analysis Code (SAC2000) that will meet the research needs of the seismic research and treaty monitoring communities. Our first step in this development was to rewrite the original Seismic Analysis Code (SAC) -- a Fortran code that was approximately 140,000 lines long -- in the C programming language. This rewrite has resulted in a much more robust code that is faster, more efficient, and more portable than the original. We have implemented important processing capabilities such as convolution and binary monograms, and we have significantly enhanced several previously existing capabilities. For example, the spectrogram command now produces a correctly registered plot of the input time series and a color image of the output spectrogram. We have also added an image plotting capability with access to 17 predefined color tables or custom color tables. A rewritten version of the readcss command can now be used to access any of the documented css.3.0 database data formats, a capability that is particularly important to the Air Force Technical Applications Center (AFTAC) and the monitoring community. A much less visible, but extremely important contribution is the correction of numerous inconsistencies and errors that have evolved because of piecemeal development and limited maintenance since SAC was first written. We have also incorporated on-line documentation and have made SAC documentation available on the Internet via the world-wide-web at http://www-ep/tvp/sac.html.

Goldstein, P.; Minner, L.

1995-08-01

325

Boundary estimation problems arising in thermal tomography  

NASA Technical Reports Server (NTRS)

Problems on the identification of two-dimensional spatial domains arising in the detection and characterization of structural flaws in materials are considered. For a thermal diffusion system with external boundary input, observations of the temperature on the surface are used in a output least squares approach. Parameter estimation techniques based on the method of mappings are discussed and approximation schemes are developed based on a finite element Galerkin approach. Theoretical convergence results for computational techniques are given and the results are applied to experimental data for the identification of flaws in the thermal testing of materials.

Banks, H. T.; Kojima, Fumio; Winfree, W. P.

1989-01-01

326

Esthesioneuroblastoma arising from the middle meatus.  

PubMed

A 35-year-old female presented with 13-year history of unilateral recurrent nasal mass, epistaxis and facial pain. Nasal examination revealed a pale glistening mass in the right nasal cavity. On probing, mass was insensitive to touch and bled on handling. Computed tomographic scan showed a mass filling the right nasal cavity, ipsilateral maxillary and ethmoid sinuses. Diagnosis of pansinusitis polyposis was made.Transnasal endoscopy-assisted excision of the mass was done, and the diagnosis of olfactory neuroblastoma was established by histopathology and confirmed by immunohistochemistry. The mass was classified as a Kadish stage B tumor. Further intervention including medial maxillectomyand ethmoidectomy, and complete endoscopic-resection of the tumor from cribriform plate was done via lateral rhinotomy approach. The tumor was found adhered to the lateral wall-the middle meatus and was easily peeled away from the cribriform plate and ethmoids. Patient was referred for radiotherapy. No evidence of loco-regional recurrence or systemic metastasis observed at 10-month follow-up. PMID:23575084

Kumar, Ashok; Sethi, Bhawna; Kumar, Yogesh; Mishra, Jai Prakash

2013-01-01

327

User's guide to SAC, a computer program for computing discharge by slope-area method  

USGS Publications Warehouse

This user's guide contains information on using the slope-area program, SAC. SAC can be used to compute peak flood discharges from measurements of high-water marks along a stream reach. The Slope-area method used by the program is the U.S. Geological Survey (USGS) procedure presented in Techniques of Water Resources Investigations of the U.S. Geological Survey, beok 3, chapter A2, "Measurement of Peak Discharge by the Slope-Area Method." The program uses input files that have formats compatible with those used by the water-surface profile program (WSPRO) described in the Federal Highways Administration publication FHWA-IP-89-027. The guide briefly describes the slope-area method documents the input requirements and the output produced, and demonstrates use of SAC.

Fulford, Janice M.

1994-01-01

328

A New Technique for Reduction the Phase Induced Intensity Noise in SAC-OCDMA Systems  

NASA Astrophysics Data System (ADS)

A new code for reduction the phase induced intensity noise has been presented. The new code is proposed for Spectral Amplitude-Coding Optical Code Division Multiple Accesses (SAC-OCDMA). This new code family we call it Dynamic Cyclic Shift (DCS) code. The DCS code reduced the effect of Multi Access Interference (MAI) due to it is the property of variable cross correlation. We find that the performance of the DCS code is a batter than other SAC-OCDMA codes such as; Random Diagonal (RD) code, Modified Quadratic Congruence (MQC) code and Modified Frequency Hopping (MFH) code. Through the mathematical calculation and simulation analysis, for the bit-error rate of DCS code is significantly better than other SAC-OCDMA codes, the effect of Phase Induced Intensity Noise is reduced. In addition, proofof-principle simulations of 10 Gb/s for 20 km have been successfully demonstrated and achieved low BER compared to the other codes.

Abd, Thanaa Hussein; Aljunid, Syed Alwee; Fadhil, Hilal Adnan

2011-12-01

329

Deafness due to bilateral endolymphatic sac tumours in a case of von Hippel-Lindau syndrome.  

PubMed Central

A case of bilateral endolymphatic sac tumours is reported. In a patient with von Hippel-Lindau syndrome, tumour growth in the right cerebellopontine angle caused deafness. The tumour was removed and classified as a metastasis from a thyroid carcinoma. However, on thyroidectomy no primary neoplasm could be found. Eight years later a similar tumour was operated on in the left petrosal bone. Histological appearance, immunocytochemical findings, and the clinical context gave evidence that the tumours had to be reclassified as endolymphatic sac tumours--extremely rare entities. The report supports the hypothesis, suggested by the few earlier case reports, that endolymphatic sac tumours could be one of the inherent tumour manifestations in von Hippel-Lindau syndrome. Images PMID:8795608

Kempermann, G; Neumann, H P; Scheremet, R; Volk, B; Mann, W; Gilsbach, J; Laszig, R

1996-01-01

330

Response of air sac mesothelium to expansion of extracellular fluid volume in Gallus domesticus.  

PubMed

In this study, scanning electron microscopy was used to examine the effects of hydrothorax on the morphology of the air sac visceral mesothelium of Gallus domesticus. Anaesthetized chickens were subjected to acute hydrodynamic pulmonary oedema induced by expansion of the extracellular fluid volume with an infusion of Ringer's solution equal to 6.5% of body weight. Tissue samples from the visceral surface of the abdominal air sacs near their ostia were obtained and fixed after death induced by anaesthetic overdose. These were compared with similar samples from control "non-volume-loaded" birds. The air sac visceral mesothelium of the volume-loaded animals presented an increased density of bulbous or swollen microvilli. These deformations were similar to changes reported in the visceral pleura of mammals subjected to hydrothorax, suggesting a commonality with regard to the role of these mesothelia in liquid clearance during pulmonary oedema. PMID:11032672

Weidner, W J

2000-01-01

331

Experimental demonstration of variable weight SAC-OCDMA system for QoS differentiation  

NASA Astrophysics Data System (ADS)

In this paper the experimental and simulation results of variable-weight spectral amplitude coding optical code division multiple access (VW-SAC-OCDMA) system is demonstrated. In the proposed system, three users with weights of 6, 4 and 2 each operating at data rate of 1.25 Gb/s represent video, data and voice services, respectively. Results show that for back-to-back system minimum average power of -20 dBm per chip is required to maintain the acceptable performance. Transmission up to 60 km of fiber is demonstrated. Using mathematical approximation the capacity of VW-SAC-OCDMA system is demonstrated.

Seyedzadeh, Saleh; Mahdiraji, Ghafour Amouzad; Sahbudin, Ratna Kalos Zakiah; Abas, Ahmad Fauzi; Anas, Siti Barirah Ahmad

2014-10-01

332

CAP/SAC-CI method for calculating resonance states of metastable anions  

NASA Astrophysics Data System (ADS)

The complex absorbing potential (CAP)/symmetry-adapted cluster-configuration interaction (SAC-CI) method has been developed to investigate resonance states of metastable anions. The method has been implemented in the projected scheme and applied to the ?? resonance state of formaldehyde. The dependence on both valence and diffuse basis sets up to g-function, the number of SAC-CI states in the projection, and the effect of perturbation selection are examined. The potential energy curve and decay width are calculated in the C-O stretching coordinate, and the Franck-Condon factors for transitions from neutral to resonance state are evaluated to interpret the electron transmission (ET) spectrum.

Ehara, Masahiro; Sommerfeld, Thomas

2012-06-01

333

Primary yolk sac tumour of the urinary bladder: A case report and review of the literature  

PubMed Central

We present a case of rare primary yolk sac tumour of the urinary bladder in adulthood. A 31-year-old female patient presented with a history of chronic ketamine abuse, which has not previously been shown to be associated with malignancy development. The final diagnosis was established only after radical cystectomy. A computed tomography (CT) scan showed paraaortic lymph node metastasis. The patient was treated with systemic chemotherapy. A review of the literature revealed that surgical excision and cisplatin-based chemotherapy remain to be the standard of care for extragonadal yolk sac tumours. PMID:24348848

MUI, WING HO; LEE, KA CHAI; CHIU, SIN CHUEN; PANG, CHUN YIN; CHU, SAU KWAN; MAN, CHI WAI; WONG, CHI SING; SZE, WING KIN; TUNG, YUK

2014-01-01

334

Clinical behavior of solitary fibrous tumors of the pleura  

Microsoft Academic Search

Background. Solitary fibrous tumors of the pleura are rare and present unpredictable clinical behavior.Methods. Between 1981 and 1998, 11 solitary fibrous tumors of the pleura were resected in 10 patients at the University Hospital of Geneva. Their clinical behavior and outcome were reviewed.Results. Seven tumors arose from the visceral pleura, and three arose from the parietal pleura. Tumors arising from

Marc de Perrot; Anne-Marie Kurt; John H Robert; Bettina Borisch; Anastase Spiliopoulos

1999-01-01

335

Molecular Genetic Analysis of Placental Site Trophoblastic Tumors and Epithelioid Trophoblastic Tumors Confirms Their Trophoblastic Origin  

Microsoft Academic Search

Trophoblastic tumors represent a unique group of human neoplasms because they are derived from fetal tissue. Except for choriocarcinoma, the neoplasms that develop from human trophoblast are poorly characterized. Placental site trophoblastic tumors and epithelioid trophoblastic tumors are thought to arise from intermediate (extravillous) trophoblasts based on histopathological studies, but direct molecular ev- idence of a trophoblastic origin has not

Robert J. Oldt; Robert J. Kurman; Ie-Ming Shih

2002-01-01

336

Primary intraosseous squamous cell carcinoma of the maxilla possibly arising from an infected residual cyst: A case report  

PubMed Central

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare type of odontogenic carcinoma arising from the jawbone. Odontogenic cysts are true cysts that arise from the dental epithelium, which is associated with tooth formation. The epithelial lining of odontogenic cysts has the potential to transform into various types of odontogenic tumor; however, this transformation from an odontogenic cyst to a malignant tumor is rare. The definitive diagnosis for PIOSCC generally requires the observation of either features of squamous cell carcinoma (SCC) within the jawbone that are distinct from direct invasion from the surface oral epithelium, or evidence of SCC arising from odontogenic epithelium and from tumors that have metastasized to the jawbone from distant sites. In the present study, a case of PIOSCC of the maxilla is presented, which, based on the results of computed tomography and the clinical course, was hypothesized to have originated from an infected residual cyst.

SUKEGAWA, SHINTARO; MATSUZAKI, HIDENOBU; KATASE, NAOKI; KANNO, TAKAHIRO; MANDAI, TOSHIKO; TAKAHASHI, YUKA; ASAUMI, JUN-ICHI; FURUKI, YOSHIHIKO

2015-01-01

337

Neuroendocrine tumors.  

PubMed

Neuroendocrine tumors comprise a broad family of tumors, the most common of which are carcinoid and pancreatic neuroendocrine tumors. The NCCN Neuroendocrine Tumors Guidelines discuss the diagnosis and management of both sporadic and hereditary neuroendocrine tumors. Most of the recommendations pertain to well-differentiated, low- to intermediate-grade tumors. This updated version of the NCCN Guidelines includes a new section on pathology for diagnosis and reporting and revised recommendations for the surgical management of neuroendocrine tumors of the pancreas. PMID:22679117

Kulke, Matthew H; Benson, Al B; Bergsland, Emily; Berlin, Jordan D; Blaszkowsky, Lawrence S; Choti, Michael A; Clark, Orlo H; Doherty, Gerard M; Eason, James; Emerson, Lyska; Engstrom, Paul F; Goldner, Whitney S; Heslin, Martin J; Kandeel, Fouad; Kunz, Pamela L; Kuvshinoff, Boris W; Moley, Jeffrey F; Pillarisetty, Venu G; Saltz, Leonard; Schteingart, David E; Shah, Manisha H; Shibata, Stephen; Strosberg, Jonathan R; Vauthey, Jean-Nicolas; White, Rebekah; Yao, James C; Freedman-Cass, Deborah A; Dwyer, Mary A

2012-06-01

338

Distribution of Kroeyerina elongata (Kroyeriidae: Siphonostomatoida, Copepoda) in the olfactory sacs of the blue shark, Prionace glauca.  

PubMed

The infection pattern of Kroeyerina elongata (Kroyeriidae, Copepoda) in the olfactory sacs of the blue shark, Prionace glauca, was investigated using 4,722 copepods from 54 olfactory sacs. Copepod prevalence and mean intensity of infection per olfactory sac were 94.0 and 91.1%, respectively, and the most intensely infected olfactory sac and shark hosted 218 and 409 copepods, respectively. There were significant linear relationships between the number of female and total copepods per left olfactory sac and shark fork length as well as between the numbers of female, male, and total copepods per shark and mean olfactory sac width and cumulative olfactory sac width. Female copepods typically outnumbered males within olfactory sacs (mean intensity ?=? 65.7 and 26.3, respectively), and no statistical differences were detected between the numbers of copepods inhabiting the left and right olfactory sacs. Copepods were not evenly distributed within olfactory sacs. Typically, female copepods occupied olfactory chambers located centrally along the length of the olfactory sac, while males infected lateral olfactory chambers nearest the naris. The orientation of most copepods (84.6%) suggested positive rheotaxis relative to the path of water through the olfactory sac. Within olfactory chambers, most mature females (68.2%) infected the first third of the peripheral excurrent channel and the adjacent fringe of olfactory lamellae, while most males (91.7%) infected the olfactory lamellae, and the 4 larval females collected were attached within the lamellar field and grasped by males. Based on the observed infection patterns and the pattern of water flow throughout the olfactory sac, a hypothesis regarding the life cycle of K. elongata is advanced wherein infective copepodids are swept into the olfactory sac from the surrounding sea and initially colonize the olfactory lamellae. Copepodids feed and mature among the olfactory lamellae, and adult males search for mates and copulate with young females among the olfactory lamellae. Inseminated females move to the peripheral excurrent channels to mature and produce ovisacs. Hatching ovisacs release free-swimming nauplii into the excurrent water flow to be swept into the milieu, where they can molt into infective copepodids that may infect new hosts. PMID:20950094

McElwain, Andrew; Kohl, Joshua W; Bojkovic, Jade; Benz, George W

2010-10-01

339

Cytogenetic analysis of a low-grade secondary peripheral chondrosarcoma arising in synovial chondromatosis.  

PubMed

Secondary chondrosarcoma is a malignant chondroid tumor arising in a benign precursor. Synovial chondromatosis is a benign chondroid lesion that rarely transforms to chondrosarcoma. We present the case of a 54-year-old male with the diagnosis of low-grade secondary peripheral chondrosarcoma developed in the context of synovial chondromatosis. Cytogenetics revealed a novel aberration t(1;14)(q23.1~24;q24.1~3). Multicolor banding (mBAND) analysis described the chromosomal regions involved in this translocation with a higher detail. Diagnosis of such borderline lesions is very difficult and cytogenetics is helpful in characterizing these tumors. PMID:23239852

Kyriazoglou, Anastasios I; Rizou, Helen; Dimitriadis, Efthimios; Arnogiannaki, Niki; Agnantis, Niki; Pandis, Nikos

2013-01-01

340

Angiosarcoma arising in schwannoma of cerebellopontine angle and later associating with meningioma in a patient with neurofibromatosis type 2.  

PubMed

Here, we describe an extremely rare case of angiosarcoma arising in schwannoma of the cerebellopontine angle and later associating with meningioma in a patient with neurofibromatosis type 2. A 33-year-old disabled Japanese man with right drop foot after surgery for an unspecified tumor demonstrated multiple tumors, suspected to be schwannoma, in the bilateral cerebellopontine angles, the cervical and lumbar spinal cord, and on the right nuchal skin. Also present were several tumors in the medulla and thoracic spinal cord suspected to be ependymoma or astrocytoma. The patient was diagnosed with neurofibromatosis type 2 according to the diagnostic criteria by the U.S. National Institutes of Health. The bilateral tumors in the cerebellopontine angle were resected to reduce symptoms and brain stem compression. Histopathological analysis revealed angiosarcoma arising in schwannoma of the bilateral tumors, and angiosarcoma was proportionally larger in the right tumor than in the left. At age 36, the patient underwent a second resection of the regrown tumor in the left cerebellopontine angle, and histopathology demonstrated mixed angiosarcoma and meningioma. That angiosarcoma arises in schwannoma is a pathogenesis within the realm of conjecture, especially that the phenomenon of mixed meningioma and angiosarcoma has not been reported to date. PMID:24599662

Sakai, Yasuhiro; Hirose, Takanori; Tomono, Ayako; Kawakami, Fumi; Nakai, Tokiko; Ohbayashi, Chiho; Mizowaki, Takashi; Tanaka, Kazuhiro; Kohmura, Eiji; Itoh, Tomoo

2014-10-01

341

13th ISTC SAC Seminar "New Perspectives of High Energy Physics"  

E-print Network

Collaboration Performance of the ATLAS Transition Radiation Tracker with Cosmic Rays and First High Energy Radiation Tracker · TRT design requirements · Timeline · Principles of Operation · TRT Electronics · Fast-OR Cosmics trigger · TRT Performance · Summary Outline #12;S.Smirnov/NRNU "MEPhI" 13th ISTC SAC Seminar 3

342

An Analytic Evaluation of the SaCS Pattern Language Including Explanations of Major Design  

E-print Network

stage specification of system requirements, system design, and safety case for a safety critical system of existing patterns and defined rules for combining these [2]. A safety critical system [3] is a system, and safety case for a safety critical system. The Safe Control Systems (SaCS) pattern language has been

Stølen, Ketil

343

Ventilation patterns of the songbird lung/air sac system during different behaviors  

PubMed Central

SUMMARY Unidirectional, continuous airflow through the avian lung is achieved through an elaborate air sac system with a sequential, posterior to anterior ventilation pattern. This classical model was established through various approaches spanning passively ventilated systems to mass spectrometry analysis of tracer gas flow into various air sacs during spontaneous breathing in restrained ducks. Information on flow patterns in other bird taxa is missing, and these techniques do not permit direct tests of whether the basic flow pattern can change during different behaviors. Here we use thermistors implanted into various locations of the respiratory system to detect small pulses of tracer gas (helium) to reconstruct airflow patterns in quietly breathing and behaving (calling, wing flapping) songbirds (zebra finch and yellow-headed blackbird). The results illustrate that the basic pattern of airflow in these two species is largely consistent with the model. However, two notable differences emerged. First, some tracer gas arrived in the anterior set of air sacs during the inspiration during which it was inhaled, suggesting a more rapid throughput through the lung than previously assumed. Second, differences in ventilation between the two anterior air sacs emerged during calling and wing flapping, indicating that adjustments in the flow pattern occur during dynamic behaviors. It is unclear whether this modulation in ventilation pattern is passive or active. This technique for studying ventilation patterns during dynamic behaviors proves useful for establishing detailed timing of airflow and modulation of ventilation in the avian respiratory system. PMID:23788706

Mackelprang, Rebecca; Goller, Franz

2013-01-01

344

12/05/2010 SAC meeting IRAM Grenoble 1 Testing of current  

E-print Network

availableAtmosphere opacity model for Pico Veleta (275 K at telescope site, 1 & 7 mm of precipitable water MUX (25% pixels lost) · Excess noise (in maps, some pixels not used) · Anti-vibration table mismatch cryogen fridge (He bottles) · Detector noise > photon noise #12;12/05/2010 SAC meeting IRAM G

Leclercq, Samuel

345

Cul-de-sacs, Superblocks and Environmental Areas as Supports of Residential Territorialization  

Microsoft Academic Search

In the suburbs, residential territorialization is most often associated with common interest developments, homeowners' associations, gated communities and sociospatial segregation. These forms of territorialization have been the subject of many critical analyses by the academic community. These criticisms, however, frequently discount the significance of the road network layout. This paper shows that cul-de-sacs, superblocks and 'environmental areas' are key factors.

Eric Charmes

2010-01-01

346

Announcement The Scientific Advisory Committee of the International Science & Technology Center (ISTC SAC)  

E-print Network

Institute of Nuclear Physics of Siberian Branch of the Russian Academy of Sciences (BINP SB RAS2nd Announcement The Scientific Advisory Committee of the International Science & Technology Center (ISTC SAC) in cooperation with The Secretariat of the International Science & Technology Center (ISTC

347

Laparoscopy through the open ipsilateral sac to evaluate presence of contralateral hernia  

Microsoft Academic Search

Purpose: Laparoscopic evaluation of the contralateral side (LECS) in children with unilateral inguinal hernia (UIH) has been criticized because of the abdominal trocar risk and costs. LECS was modified to avoid abdominal trocar insertion by using the open hernia sac for instrumentation (OHLECS). This study was performed to determine the utility, safety, and effectiveness of this technique. Methods: During a

Mark L. Wulkan; Eugene S. Wiener; Nancy VanBalen; Peter Vescio

1996-01-01

348

The Design of a University's SACS Accreditation World Wide Web Site.  

ERIC Educational Resources Information Center

This paper describes the design of a Southern Association of Colleges and Schools (SACS) World Wide Web site to act as a living documents repository for university accreditation. Topics addressed include: instructional design and development of a functional flowchart; interface design; and interactive elements, including bulletin boards and…

Crawford, Caroline M.

349

From Performance Management to Capacity-Building: An Escape from the "Cul De Sac"?  

ERIC Educational Resources Information Center

This article examines the many critiques of educational policies concerning the National Curriculum and the standards and testing regimes for pupils and teachers associated with it. It goes on to suggest that there is a danger of educational researchers and policy-makers arguing themselves into a "cul de sac" where an unproductive stand-off may…

Storey, Anne

2004-01-01

350

Hemopoietic stem cells in murine embryonic yolk sac and peripheral blood  

Microsoft Academic Search

Disaggregated embryonic yolk sac cells and circulating peripheral blood cells were obtained from normal murine day 9 embryos, prior to the formation of the fetal liver. These cells were microinjected transplacentally into days 11-15 W mutant anemic fetuses, when the fetal liver was the major hemopoietic organ. In a small proportion of the recipient animals examined after birth, long-term repopulation

J. F. Toles; D H Chui; L W Belbeck; E Starr; J E Barker

1989-01-01

351

A Cross-Ethnic Validity Study of the Shortform Assessment for Children (SAC)  

ERIC Educational Resources Information Center

Objective: This study examined the cross-ethnic measurement equivalence of the Shortform Assessment for Children (SAC) using a sample of 562 African American and 692 White children. Method: A prospective, two-panel survey design was used in this study. Baseline and 6-month follow-up data were used to conduct analyses of the reliability and…

Tyson, Edgar H.; Glisson, Charles

2005-01-01

352

Long-term fate of the aneurysmal sac after endoluminal exclusion of abdominal aortic aneurysms  

Microsoft Academic Search

Purpose: Shrinkage of an abdominal aortic aneurysm (AAA) is the hallmark of successful endoluminal treatment. Our goal was to prospectively assess the midterm to long-term shrinkage of the AAA sac after endovascular repair. Methods: A total of 123 patients with AAA underwent endoluminal treatment with the Ancure device at our institution between February 1996 and February 2000. At least a

Robert Y. Rhee; Mark K. Eskandari; Albert B. Zajko; Michel S. Makaroun

2000-01-01

353

Pathogenesis of developmental defects induced in the rat by amniotic sac puncture  

Microsoft Academic Search

The morphogenesis of developmental defects induced by amniotic sac puncture was studied at the gross and microscopic levels. In fetuses recovered from 15 min to 48 h after amniocentesis, a pattern of hemorrhagic lesions, excessive accumulation of interstitial fluid, followed by tissue necrosis and leading ultimately to the reduction or amputation of distal limb segments and morphological changes in the

L. A. Kennedy; T. V. N. Persaud

1977-01-01

354

Follow-Up Survey of Former SAC Students Who Transferred to a Four Year College.  

ERIC Educational Resources Information Center

In 1982, a follow-up study was conducted of Santa Ana College (SAC) graduates who had transferred to and were currently attending four neighboring four-year colleges: California State University, Fullerton; California State University, Long Beach; California Polytechnic University; and the University of California, Irvine. Surveys were mailed to…

Slark, Julie; Bateman, Harold

355

SAC 2005 -Santa Fe Sanitizing using Metadata in MetaXQuery  

E-print Network

SAC 2005 - Santa Fe Sanitizing using Metadata in MetaXQuery Hao Jin and Curtis Dyreson School of E.E. and Computer Science Washington State University USA Sanitizing using Metadata in MetaXQuery - Jin and Dyreson Outline · XQuery · Metadata · Sanitize · Experiments · Summary Sanitizing using Metadata in Meta

Dyreson, Curtis

356

Faraday Discuss. Chem. Sac., 1983, 76,65-75 Electrical Double-layer Interactions in  

E-print Network

Faraday Discuss. Chem. Sac., 1983, 76,65-75 Electrical Double-layer Interactions in Concentrated In this paper we compare three methods for deducing the effective pair potential that describes the double-layer that the electrostatic or electrical double-layer interactions between colloidal particles are responsible for giving

Chan, Derek Y C

357

2 CFR Appendix X to Part 200 - Data Collection Form (Form SF-SAC)  

...2014-01-01 false Data Collection Form (Form SF-SAC) X Appendix X to Part 200 Grants and Agreements Office of Management...AUDIT REQUIREMENTS FOR FEDERAL AWARDS Pt. 200, App. X Appendix X to Part 200—Data Collection Form (Form...

2014-01-01

358

Probabilistic Basis for 2000 SAC Federal Emergency Management Agency Steel Moment Frame Guidelines  

Microsoft Academic Search

This paper presents a formal probabilistic framework for seismic design and assessment of structures and its application to steel moment-resisting frame buildings. This is the probabilistic basis for the 2000 SAC Federal Emergency Management Agency ~FEMA! steel moment frame guidelines. The framework is based on realizing a performance objective expressed as the probability of exceeding a specified performance level. Performance

C. Allin Cornell; Fatemeh Jalayer; Ronald O. Hamburger; Douglas A. Foutch

2002-01-01

359

Laparoscopic repair of hernia in children: Comparison between ligation and nonligation of sac  

PubMed Central

Aim: The essence of the current techniques of laparoscopic hernia repair in children is suture ligation of the neck of the hernia sac at the deep ring with or without its transection. Some studies show that during open hernia repair, after transection at the neck it can be left unsutured without any consequence. This study was aimed to see if the same holds true for laparoscopic hernia repair. Materials and Methods: Sixty patients (52 boys and eight girls, 12-144 months) with indirect inguinal hernia were randomized for laparoscopic repair either by transection of the sac alone (Group I) or transection plus suture ligation of sac at the neck (Group II). Outcome was assessed in terms of time taken for surgery, recurrence, and other complications. Result: Thirty-eight hernia units in 28 patients were repaired by transection alone (Group I) and 34 hernia units in 29 patients were repaired by transection and suture ligation (Group II). Three patients were found to have no hernia on laparoscopy. Recurrence rate and other complications were not significantly different in the two groups. All recurrences occurred in hernias with ring size more than 10 mm. Conclusion: Laparoscopic repair of hernia by circumferential incision of the peritoneum at the deep ring is as effective as incision plus ligation of the sac. PMID:24741209

Pant, Nitin; Aggarwal, Satish Kumar; Ratan, Simmi K.

2014-01-01

360

13th SAC ISTC Seminar "New Perspectives of High Energy Physics"  

E-print Network

13th SAC ISTC Seminar "New Perspectives of High Energy Physics" Novosibirsk 1-5 September 2010 V TRANSITION RADIATION TRACKER #12;V.Myalkovskiy 13th momentum measurements (with Si-tracker and pixels) Stand-alone electron identification TRANSITION RADIATION

361

Peripheral Nerve Tumors  

Microsoft Academic Search

\\u000a Peripheral nerve tumors (PNTs) are rare soft tissue lesions that can arise anywhere on the body and as a result have a wide\\u000a differential diagnosis, which is often confirmed to be a PNT only at surgery. PNTs occur both sporadically and within the\\u000a context of genetically predisposing syndromes; hence, a thorough history of the mass and associated symptoms, with a

Joseph Wiley; Asis Kumar Bhattacharyya; Gelareh Zadeh; Patrick Shannon; Abhijit Guha

362

The undifferentiated malignant neoplasm. Identification of lymphoma arising in skeletal muscle by immunohistochemical analysis.  

PubMed

The undifferentiated malignant neoplasm presents a significant problem in the intelligent selection of therapy. Because of advances in chemotherapy, there are cancers that are effectively palliated, and sometimes cured if appropriately treated. Characterization of tumors by immunohistochemical stains drastically reduces the incidence of "undifferentiated" diagnoses and will optimize patient management, as illustrated by two cases of large-cell lymphoma arising in skeletal muscle. PMID:2414476

Berg, A R; Linder, J; Anderson, R W; Tempero, M A; Edney, J A; Armitage, J O

1985-11-01

363

Osteosarcoma arising from the parapharyngeal space: A case report  

PubMed Central

The current study presents a rare case of osteoblastic osteosarcoma arising from an extremely rare site, namely, the parapharyngeal space. To the best of our knowledge, this is the first study of computed tomography (CT) and magnetic resonance imaging (MRI) of an osteosarcoma in the parapharyngeal space with pathological correlation. A 56-year-old male presented with a mass of the right facial region. CT and MRI showed a heterogeneous mass, with ossification or calcification, occupying the parapharyngeal space. Open biopsy revealed an osteoblastic osteosarcoma containing calcified malignant osteoid. Lung CT also showed multiple lung metastases at the time of the first visit to the Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine (Osaka, Japan). Systemic chemotherapy and radiotherapy were administered to the patient for palliation. The patient was alive at the 24-month follow-up subsequent to this treatment. Although a definitive diagnosis requires the use of a biopsy, the CT and MRI findings described in the present study suggest inclusion of this rare tumor in the differential diagnosis that is formed when such findings occur in the parapharyngeal space. The present study also briefly discusses osteosarcoma of the parapharyngeal space. PMID:25120697

HOSHI, MANABU; TAKADA, JUN; OEBISU, NAOTO; NAKAMURA, HIROAKI

2014-01-01

364

Primary germ cell tumors of the mediastinum: 10 years of experience in a tertiary teaching hospital.  

PubMed

Germ cell tumors occur mostly in the gonad. Extragonadal germ cell tumors are rare, and most occur in the retroperitoneum and mediastinum. Primary mediastinal germ cell tumors are often found in the anterior portion of the mediastinum and include teratomas and non-teratomatous tumors. Non-teratomatous tumors include seminomas and malignant non-seminomatous germ cell tumors (MNSGCTs). MNSGCTs include yolk sac tumors, choriocarcinomas, embryonal carcinomas, and mixed type germ cell tumors. Teratomas are the most common germ cell tumors of the mediastinum, and seminomas are the most common non-teratomatous germ cell tumors of the mediastinum. Cases of primary mediastinal MNSGCT reported in the literature are rare. In this report, we review all primary mediastinal germ cell tumors from a 10-year period at the Chung-Ho Memorial Hospital of Kaohsiung Medical University. A total of 14 cases were reviewed, including 11 patients with mature teratomas, two with yolk sac tumors, and one with seminoma. We discuss the differences in clinical presentation, histopathologic characteristics, treatment, and prognosis. PMID:16248122

Yang, Chih-Jen; Cheng, Meng-Shuan; Chou, Shah-Hwa; Tsai, Kun-Bow; Huang, Ming-Shyan

2005-09-01

365

Brain Tumor  

MedlinePLUS

... from Mayo Clinic Overview By Mayo Clinic Staff Brain tumor This shows a tumor that likely began ... Make a difference today. Learn more Give now Brain tumor Overview Symptoms & causes Diagnosis and treatment at ...

366

Corso di Laurea in Scienze dell'Architettura e della Citt -SAC Laboratorio di Lettura e Progetto dell'Architettura -LPA  

E-print Network

Corso di Laurea in Scienze dell'Architettura e della Città - SAC Laboratorio di Lettura e Progetto dell'Architettura - LPA Laboratorio di progettazione 2A, AA 2010/2011, Prof. G. Strappa w3.uniroma/sac Giulia via A. Gramsci 53, Roma Direttore Giuseppe Strappa (presidente del C.d.L. SAC) Tutors Alessandro

Di Pillo, Gianni

367

The Probabilistic Basis for the 2000 SAC/FEMA Steel Moment Frame C. Allin Cornell 1 , Member, ASCE, Fatemeh Jalayer 2 , Ronald O. Hamburger 3 , Member,  

E-print Network

The Probabilistic Basis for the 2000 SAC/FEMA Steel Moment Frame Guidelines C. Allin Cornell 1 for the 2000 SAC/FEMA steel moment frame guidelines. The framework is based on realizing a performance of the performance objective being met. This format has been adopted in the SAC/FEMA guidelines. Keywords

Sweetman, Bert

368

Classification de symboles avec un treillis de Galois et une reprsentation par sac A classification approach based on Galois lattice and bag of words representation  

E-print Network

Classification de symboles avec un treillis de Galois et une représentation par sac de mots- naissance de symboles graphiques en combinant un treillis de concepts avec une représentation par sac de aux approches clas- siques, sans sac de mots et à plusieurs classifieurs usuels, évalués sur

Boyer, Edmond

369

Primary intratesticular spindle cell tumors: interdigitating dendritic cell tumor and inflammatory myofibroblastic tumor.  

PubMed

Spindle cell neoplasms arising in the testis are uncommon; most cases belong to the category of gonadal stromal tumors, and the presence of distinctive clinical and pathological features usually lead to a definitive diagnosis. In some instances, however, the diagnosis of these tumors can be challenging and special techniques are needed. The present study reports 2 unusual cases of primary intratesticular tumors showing a striking morphology, characterized by spindle to stellate cells in a lymphoid background. The diagnosis of interdigitating dendritic cell tumor and inflammatory myofibroblastic tumor was established in the 2 cases, and their probable origin in cells of the accessory immune system is discussed. Although both tumors share similar histological features, their immunohistochemical profiles were decisive for a definitive diagnosis. PMID:18805870

Nistal, Manuel; Gonzalez-Peramato, Pilar; Serrano, Alvaro; Reyes-Mugica, Miguel; Cajaiba, Mariana M

2011-02-01

370

[Gastrointestinal stroma tumor].  

PubMed

Gastrointestinal stromal tumor (GIST) represents less than 3% of gastrointestinal malignancies. However, it is the most common mesenchymal tumor of the digestive tract. GIST is characterized by the expression tyrosine kinase CD117, which differentiates it from other mesenchymal tumors such as leiomyomas, leio-miosarcomas, leiomyoblastoma and neurogenic tumors that do not express this protein. 70-80% of the GIST are benign and located mostly in the stomach and small intestine (> 90%).They can also arise from any portion of the digestive tract, mesentery, omentum and retroperitoneum. Malignant GISTs are usually large (> 5 cm), with a high mitotic index, and it can metastasize to the liver and peritoneum. The treatment is surgical resection.Good results have been reported with tyrosine kinase inhibitor STI571. The treatment is the surgical resection; in cases of surgical resection tumors cannot do it, radiotherapy and chemotherapy is carried out. A 43 year-old patient is presented, admitted to present pain in the epigastrium, melena in an occasion. The ecography, CT scan, and laparoscopic view, showed a tumor in the second portion of the duodenum, approximately 10 cm size. Whipple´s operation was carried out (cephalic pancreatoduodenectomy) with conservation of the pylorus (Traverso-Longmire), resecting the entirely tumor. Final results of pathological anatomy informed: fusocelular tumor of the gastrointestinal estroma (GIST of duodenal wall), with high potential of malignancy. Size of the tumor 9,5 cm, mitotic index of 9 for 50 HPF with high positive for CD117, CD34. Two years later of theintervention he presents a good evolution. PMID:25293993

Ramos Socarrás, Aníval Ernesto; Vallés Gamboa, Moraima Emilia; Rodríguez Núñez, José Rolando; Neyra Rodríguez, Carlos Manuel; Vargas La O, Francisco Antonio

2014-01-01

371

Epithelioid angiosarcoma arising in schwannoma: report of three Chinese cases with review of the literature.  

PubMed

Angiosarcoma arising in a schwannoma is extremely rare with only eleven cases having been reported in the English literature. We describe here three further cases occurring in adult males with a pre-existing longstanding schwannoma. The tumor arose each from the vagus, ischiadic and adrenergic nerve respectively. None of the patients had von Recklinghausen's disease. Microscopically, the tumor was composed of a mixture of a benign schwannoma and an epithelioid angiosarcoma. The two components changed abruptly within the tumor. The endothelial cell differentiation was confirmed by immunohistochemistry. A review of published reports, including the present cases, suggests a poor prognosis with a high rate of local recurrence, distant metastasis and mortality. PMID:22726071

Li, Chao; Chen, Ying; Zhang, Hong; Zheng, Xiongwei; Wang, Jian

2012-07-01

372

Canine mammary gland tumors.  

PubMed

An understanding of the known biologic facts of this disease and methodical evaluation of the individual patient are necessary prerequisites for outlining rational courses of therapy for dogs afflicted with mammary tumors. Because of the common occurrence of multiple tumors arising at various stages of development simultaneously and the heterogeneity of histology of the complex (mixed tissue types) tumors, presurgical biopsy is recommended only in cases in which mast cell tumor or anaplastic carcinoma is suspected. Although investigative work is being performed regarding the efficacy of chemotherapy, radiation therapy, and immunotherapy, surgery still remains the mainstay in treatment of this condition. No one surgical procedure fits the needs of all patients, although it seems logical to remove as much breast tissue as is reasonable in each circumstance owing to the multicentric nature of the disease. Ovariohysterectomy has not been demonstrated to be of value in treatment of dogs with mammary tumors, but it is a markedly effective method of preventing mammary tumors if it is performed before puberty; it is moderately effective if performed before the dog is 21/2 years of age. PMID:3892866

Ferguson, H R

1985-05-01

373

Successful Chemoradiotherapy for Undifferentiated Malignant Neoplasm Arising from the Left Pulmonary Artery  

PubMed Central

Undifferentiated malignant neoplasms, which occur primarily in the pulmonary artery, are extremely rare and associated with poor outcomes as there is no effective therapy. A 67-year-old woman visited our hospital with complaints of dry cough and dyspnea on exertion. A contrast-enhanced chest computed tomography revealed an intravascular tumor obstructing the left pulmonary artery and a pedunculated lesion extending to the main and right pulmonary artery. Multiple metastases in the lung, bones and bilateral adrenal glands were identified by fluorodeoxyglucose-positron emission tomography. A small sample was obtained by catheter aspiration biopsy of the intravascular tumor, and examination revealed undifferentiated small atypical cells. The tumor was diagnosed as an undifferentiated neoplasm arising from the pulmonary artery based on immunohistochemical findings, including the absence of expressions of organ-specific markers. Systemic chemotherapy (paclitaxel and carboplatin) and concurrent radiation were performed as treatment for the primary tumor. Marked shrinkage of the intravascular tumor was achieved, and no serious adverse events were observed during therapy. Chemotherapy was continued for 5 months, but the patient died because of tumor progression 9 months after the initial diagnosis. Chemoradiotherapy has efficacy against undifferentiated neoplasm of the pulmonary artery. PMID:25202263

Kumagai, Hozumi; Nio, Kenta; Okumura, Yuta; Komoda, Masato; Shirakawa, Tsuyoshi; Kusaba, Hitoshi; Yasuda, Shioto; Odashiro, Keita; Arita, Shuji; Ariyama, Hiroshi; Yamada, Yuichi; Yamamoto, Hidetaka; Oda, Yoshinao; Nakamura, Katsumasa; Akashi, Koichi; Baba, Eishi

2014-01-01

374

Mandibular phosphaturic mesenchymal tumor-mixed connective tissue variant in a young girl.  

PubMed

Phosphaturic mesenchymal tumor-mixed connective tissue variant (PMTMCT) is an extremely rare tumor associated with tumor-induced osteomalacia. The majority occur in middle age and arise from the extremities. This report describes a young girl with PMTMCT arising in the mandible and with no evidence of paraneoplastic syndrome. PMID:23394315

Luo, Lisa; Low, Nelson; Vandervord, John

2013-11-01

375

Lacrimal sac compression by an anterior ethmoidal mucocele presenting as a late complication of dacryocystorhinostomy  

PubMed Central

This was an unusual case of lacrimal sac compression by an anterior ethmoidal mucocele presenting as a late complication of a dacryocystorhinostomy (DCR) that was jointly managed by ophthalmic and ENT surgeons via an endoscopic approach. A 22-year-old lady presented with a 12-month history of a painless lump in her left medial canthus area and a 6-month history of left intermittent epiphora. She had a DCR when she was 15 years old with initial symptom control until recent recurrence. There were no nasal or other eye symptoms. The rest of the eye and nasendoscopic examinations were unremarkable. An MRI scan suggested a dacryocystocele; however, a further CT scan revealed a 1.6 cm cystic lesion consistent with an anterior ethmoidal mucocele compressing the lacrimal sac. An endoscopic left anterior ethmoidectomy with marsupialisation of the mucocele was performed in combination with an endoscopic DCR. She made good post-operative recovery. PMID:24964413

Olaleye, Oladejo; Salleh, Shizalia; David, Don; Bickerton, Richard

2013-01-01

376

Hybrid SCM SAC-OCDMA System Employing New Optical Spectral Amplitude Direct Decoding Detection Technique  

NASA Astrophysics Data System (ADS)

In this research, a hybrid subcarrier multiplexed spectral-amplitude-coding optical code-division-multiple-access (SCM SAC-OCDMA) system is proposed for the purpose of combining the advantages of both techniques. SAC-OCDMA is employed because of its ability to eliminate the Multiple Access Interference (MAI) when code sequences with fixed in-phase cross correlation are used. In order to enhance the channel data rate of the OCDMA systems, the SCM technique is used. As a result, the hybrid system is robust against interference and is much more spectrally efficient. The system utilizes double weight (DW) code that has a weight W equal to two, code length N equal to six and cross correlation ? equal to 1. A simple and new detection technique called optical spectral amplitude direct decoding is proposed. Based on the theory and experimental simulation results obtained, the new proposed detection technique provides a better performance than the conventional balanced detection technique.

Sahbudin, R. K. Z.; Abdullah, M. K.; Samad, M. D. A.; Mahdi, M. A.; Ismail, M.

377

Papillary neoplasm of the endolymphatic sac in a patient with von Hippel-Lindau disease.  

PubMed Central

Glandular tumours involving the middle ear and the mastoid are rare, and distinguishing between adenoma and adenocarcinoma is difficult. Two distinct histopathological patterns are accepted. While their clinical presentation differs, both require primary surgical treatment and both have a high rate of local recurrence. The papillary form takes a more aggressive course and wider regional spread. This pattern occurs predominantly in women. Its microscopic appearance and clinical course have been extensively described by Heffner who considered it as "low-grade adenocarcinoma of probable endolymphatic sac origin". A few cases have been associated with von Hippel-Lindau disease. The case of a 32 year old black woman is described. It is suggested that papillary adenocarcinoma of the endolymphatic sac should be considered in the spectrum of neoplasms seen in von Hippel-Lindau disease. Images PMID:7962613

Delisle, M B; Uro, E; Rouquette, I; Yardeni, E; Rumeau, J L

1994-01-01

378

Macrofauna community inside and outside of the Darwin Mounds SAC, NE Atlantic  

NASA Astrophysics Data System (ADS)

Over the past two decades, growing concerns have been raised regarding the effects of towed fishing gears, such as trawls and dredges, on deep-sea biodiversity and ecosystem functioning. Trawling disturbs the benthic communities both physically and biologically, and can eliminate the most vulnerable organisms and modify habitat structure; chronically disturbed communities are often dominated by opportunistic species. The European Union is under obligation to designate a network of offshore Special Areas of Conservation (SACs) and Marine Protected Areas (MPAs) by the end of 2012 based on the perceived expectation that these networks will help protect marine biodiversity and that within these areas, faunal abundance and diversity will be higher than the surrounding fished areas. The Darwin Mounds, only discovered in 1998, are located in the Rockall Trough, NE Atlantic at a depth of ~ 1000 m. Deep-water trawling regularly took place in the region of the Darwin Mounds; however in 2004 the mounds were designated as the first offshore SAC in UK and the area is now closed to bottom trawling. As part of the HERMIONE programme the influence of human impact on the Oceans was one of the key themes and in June 2011, an investigation of the macrofaunal community structure at comparable sites both inside and outside of the Darwin Mound SAC was undertaken. Macrofaunal communities were found to differ significantly, with the difference mostly driven by changes in the abundance of polychaetes, crustaceans and nematodes whilst no significant differences were seen for the other phyla. Whereas overall macrofaunal abundance was higher outside the SAC compared to within, this pattern varies considerably between phyla. Diversity indices showed no significant differences between protected and unprotected sites. This could indicate that a few years of preservation are not enough time to determine a recovery by the macrofaunal community of cold-water ecosystems and that a continued monitoring over a longer term is necessary to fully understand the impact of fishery closures.

Serpetti, N.; Gontikaki, E.; Narayanaswamy, B. E.; Witte, U.

2012-11-01

379

Isolation and characterization of the Fc receptor from the fetal yolk sac of the rat  

Microsoft Academic Search

The yolk sac of the fetal rat and the prox- imal small intestine of the neonatal rat selectively trans- port maternal IgG. IgG-Fc receptors are thought to mediate transport across the epithelium of both tis- sues. We used a mouse mAb (MC-39) against the 45-54-kD component of the Fc receptor of the neona- tal intestine to find an antigenically related

Denise M. Roberts; Maja Guenthert; Richard Rodewald

1990-01-01

380

Altered fructan accumulation in transgenic Lolium multiflorum plants expressing a Bacillus subtilis sacB gene  

Microsoft Academic Search

Ryegrasses, like many C3 plants, accumulate fructan, which plays an important role in assimilate partitioning, as the major non-structural storage carbohydrate. The present study describes the transformation of a Bacillus subtilis sacB gene, with vacuolar targeting signal sequences and driven by constitutive promoters, into Italian ryegrass (Lolium multiflorum Lam.) by microprojectile bombardment of embryogenic suspension cells. The expression of the

X. Ye; X. Wu; H. Zhao; M. Frehner; J. Nösberger; I. Potrykus; G. Spangenberg

2001-01-01

381

AUTORADIOGRAPHIC STUDY OF SUGAR AND AMINO ACID ABSORPTION BY EVERTED SACS OF HAMSTER INTESTINE  

Microsoft Academic Search

Autoradiographs were prepared from frozen sections of evcrted sacs of hamster jejunum which had been incubated in vitro with C 14- or H~-labcled sugars and amino acids. When such tissue was incubated in 1 mM solutions of L-valine or L-methionine, columnar absorp- tivc cells at tips of villi accumulated these amino acids to conccntrations ranging from 5 to 50 millimoles

WILLIAM B. KINTER; T. HASTINGS WILSON

1965-01-01

382

Volatile constituents of dog ( Canis familiaris ) and coyote ( Canis latrans ) anal sacs  

Microsoft Academic Search

The volatile organic compounds from the anal sac secretions of male and female dogs and coyotes were examined using gas chromatography and gas chromatography-mass spectrometry. Short chain (C2–C6) acids and trimethylamine were major constituents. Changes in the type and abundance of the volatiles were examined across state of estrus, species, and gender. No consistent difference in the pattern of volatiles

George Preti; Earl L. Muetterties; Joseph M. Furman; James J. Kennelly; Bradford E. Johns

1976-01-01

383

Molecular markers of yolk sac fry development in nine families of lake trout.  

PubMed

Salmonids in certain areas of North America and northern Europe suffer from reproductive disturbances manifested through the death of yolk sac fry. These disturbances are referred to as early mortality syndrome (EMS) in the Great Lakes region and M74 in the Baltic Sea. Both of these syndromes have been associated with reduced concentrations of thiamine in affected females and their eggs. However, large variations in signs and mortality, both within and between the individual syndromes, have been reported. Yolk sac fry mortality (M74) in Atlantic salmon Salmo salar has been shown to be associated with reduced DNA binding of the hypoxia-inducible transcription factor 1 (HIF-1), reduced production of vascular endothelial growth factor (VEGF) protein, decreased capillary density, and down-regulation of adult-type globin gene transcription (which is responsible for the protein part of adult hemoglobin). One of the main effects of all of these changes is reduced oxygen transport to the tissues of affected fry. In this study, the developmental patterns of HIF-1 DNA binding, VEGF protein expression, and adult-type globin gene transcription were analyzed in nine family groups of Lake Michigan lake trout Salvelinus namaycush. The results indicate that HIF-1 DNA binding and globin gene transcription increase from hatch to the end of yolk sac stage. Interindividual and between-family biological variations were detected, especially in VEGF protein expression and globin gene transcription. Our results demonstrate the possibility of using these molecular markers in investigating the etiology of EMS and making comparisons between the mechanisms of different salmonid yolk sac fry mortalities. PMID:20218502

Vuori, Kristiina A; Paavilainen, Tiia; Nikinmaa, Mikko; Czesny, Sergiusz; Rinchard, Jacques

2009-12-01

384

Electronic structure and optical properties of conjugated molecules: SAC-CI study  

NASA Astrophysics Data System (ADS)

Electronic structure and optical properties of some organic conjugated molecules, chelating hetero-atomic conjugated ligands and some derivatives of the UVB blocking cinnamates, have been investigated by the SAC-CI method. The absorption and emission spectra of these molecules have been reproduced in high accuracy. The excited-state geometry relaxation was interpret based on the electrostatic force theory. The present work provides a useful basis for the theoretical design predicting the optical properties of the molecules.

Ehara, Masahiro; Yun-peng, Lu; Promkatkaew, Malinee; Hannongbua, Supa

2012-12-01

385

Light Intensity and Salinity Effects on Eggs and Yolk Sac Larvae of the Summer Flounder  

Microsoft Academic Search

The effects of light intensity and salinity on eggs and yolk sac larvae of summer flounder Paralichthys dentatus were examined under controlled laboratory conditions. Fertilized eggs (early gastrula stage), obtained by induced spawning of captive broodstock, were stocked (53 eggs\\/L) into forty-eight 5-L translucent containers under light intensities of 0 (constant dark), 500, 1,000, and 2,000 lx and at salinities

Wade O. Watanabe; Michael W. Feeley; Simon C. Ellis; Eileen P. Ellis

1998-01-01

386

Temperature Effects on Eggs and Yolk Sac Larvae of the Summer Flounder at Different Salinities  

Microsoft Academic Search

The combined effects of temperature and salinity on eggs and yolk sac larvae of summer flounder Paralichthys dentatus were examined under controlled laboratory conditions. Fertilized eggs (early gastrula stage), obtained by induced spawning of captive broodstock at 17°C and 36 g\\/L salinity, were stocked (60 eggs\\/L) into forty-five 5-L translucent containers at temperatures of 16, 20, and 24°C and at

Wade O. Watanabe; Simon C. Ellis; Eileen P. Ellis; Michael W. Feeley

1999-01-01

387

Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment.  

PubMed

A lot of effort has been done to study how cancer cells react to low-oxygen tension, a condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor are incapable to restore oxygenation, therefore perpetuating hypoxia, which, in turn, will fuel tumor progression, metastasis and resistance to antitumor therapies. Nevertheless, how stromal components including blood and lymphatic endothelial cells, pericytes and fibroblasts, as well as hematopoietic cells, respond to low-oxygen tension in comparison with their normoxic counterparts has been a matter of investigation in the last few years only and, to date, this field of research remains poorly understood. In general, opposing phenotypes can arise from the same stromal component when embedded in different tumor microenvironments, and, vice versa, different stromal components can have opposite reaction to the same tumor microenvironment. In this article, we will discuss the emerging link between tumor stroma and hypoxia, and how this complexity is translated at the molecular level. PMID:23604130

Casazza, A; Di Conza, G; Wenes, M; Finisguerra, V; Deschoemaeker, S; Mazzone, M

2014-04-01

388

Accessory lymph sacs and body fluid partitioning in the lizard, Sauromalus hispidus.  

PubMed

Chuckwalla lizards (genus Sauromalus) may accumulate substantial quantities of body fluid in extracoelomic, lateral abdominal spaces called accessory lymph sacs. The lymph sac fluid (LSF) of S. hispidus is similar to that of serum in Na+, K+ and Cl- concentrations, but the total protein content (3.58 +/- 0.20 g dl-1) is only half that measured in serum (7.05 +/- 0.26 g dl-1). These analyses confirm that LSF is an extravascular form of extracellular fluid, similar in composition to true lymph. Measurements of body fluid partitioning by dilution analysis indicate that Sauromalus hispidus Stejnejer possesses a comparatively large (38.9% body mass) and labile extracellular fluid volume (ECFV), and that the volume of LSF is dependent on the ECFV. Expansion of the ECFV (and subsequent accumulation of LSF) is observed following large, intercompartmental fluid shifts from intracellular to extracellular locations when lizards are kept inactive in simulated hibernation, are injected with KCl in amounts similar to those found in their field diet, and are hydrated with NaCl that is isotonic to their body fluids. These data collectively suggest that the lymph sacs of chuckwallas facilitate expansion of the ECFV, and may be adaptive not only as a means to store body water, but to accommodate transient shifts in body fluid from intracellular to extracellular locations. PMID:3958676

Smits, A W

1986-03-01

389

Evaluation of Refractivity Profiles from CHAMP and SAC-C GPS Radio Occultation  

NASA Technical Reports Server (NTRS)

The GeoForschungsZentrum's Challenging Minisatellite Payload for Geophysical Research and Application (CHAMP, Germany-US) and the Comision Nacional de Actividades Especiales' Satelite de Aplicaciones Cientificas-C (SAC-C, Argentina-US) missions are the first missions to carry a second-generation Blackjack Global Positioning System (GPS) receiver. One of the new features of this receiver is its ability to sense the lower troposphere closer to the surface than the proof-of-concept GPS Meteorology experiment (GPS/MET). Since their launch, CHAMP and SAC-C have collected thousands of GPS radio occultations, representing a wealth of measurements available for data assimilation and Numerical Weather Prediction (NWP). In order to evaluate the refractivity data derived by the Jet Propulsion Laboratory (JPL) from raw radio occultation measurements, we use Data Assimilation Office (DAO) 6-hour forecasts as an independent state of the atmosphere. We compare CHAMP and SAC-C refractivity (processed by JPL) with refractivity calculated from the DAO global fields of temperature, water vapor content and humidity. We show statistics of the differences as well as histograms of the differences.

Poli, Paul; Ao, Chi On; Joiner, Joanna; delaTorreJuarez, Manuel; Hoff, Raymond

2002-01-01

390

Evaluation of Refractivity Profiles From Champ and SAC-C GPS Radio Occultation  

NASA Technical Reports Server (NTRS)

The CHAMP and SAC-C missions are the first missions to carry a second-generation 'Blackjack' GPS receiver. One of the new features of this receiver is its ability to sense the lower troposphere closer to the surface than the proof-of-concept GPS/MET 1995 experiment. Since their launch, CHAMP and SAC-C have collected thousands of GPS radio occultations, representing a wealth of measurements available for data assimilation in Numerical Weather Prediction (NWP) models. In order to evaluate the refractivity data derived by JPL from raw radio occultation measurements, we use Data Assimilation Office (DAO) shout forecasts as an independent state of the atmosphere. We compare CHAMP and SAC-C refractivity (processed by JPL) with refractivity calculated from the DAO global fields of temperature, water vapor content and humidity. We will show statistics of the differences as well as Probability Density Functions (PDFs) of the differences. Depending upon availability of AIRS data, we plan to show individual profile comparisons between GPS radio occultation and AIRS retrievals.

Poli, Paul; Joiner, Joanna; delaTorreJuarez, Manuel; Hoff, Raymond M.; Atlas, Robert (Technical Monitor)

2002-01-01

391

Evaluation of Refractivity Profiles from CHAMP and SAC-C GPS Radio Occultation  

NASA Technical Reports Server (NTRS)

The CHAMP and SAC-C missions are the first missions to carry a second-generation 'Blackjack' GPS receiver. One of the new features of this receiver is its ability to sense the lower troposphere closer to the surface than the proof-of-concept GPS/MET 1995 experiment. Since their launch, CHAMP and SAC-C have collected thousands of GPS radio occultations, representing a wealth of measurements available for data assimilation in Numerical Weather Prediction (NWP) models. In order to evaluate the refractivity data derived by JPL from raw radio occultation measurements, we use Data Assimilation Office (DAO) 6-hour forecasts as an independent state of the atmosphere. We compare CHAMP and SAC-C refractivity (processed by JPL) with refractivity calculated from the DAO global fields of temperature, water vapor content and humidity. We will show statistics of the differences as well as Probability Density Functions (PDFs) of the differences. Depending upon availability of AIRS data, we plan to show individual profile comparisons between GPS radio occultation and AIRS retrievals.

Poli, Paul; Joiner, Joanna; delaTorreJuarez, Manuel; Hoff, Raymond M.; Atlas, Robert (Technical Monitor)

2002-01-01

392

Pathological, immunohistochemical and microbiologicalal analysis of lacrimal sac biopsies in patients with chronic dacrocystitis  

PubMed Central

AIM To analyze cases of obstruction of the nasolacrimal duct which creates a fertile environment for secondary bacterial infection and can result in dacryocystitis, which is a constant threat to cornea and orbital soft tissue and a potential source of endophthalmitis following intraocular surgery. The majority of obstructions of the lacrimal excretory outflow system are acquired ones occurring in adulthood and involving the distal parts of the system. Acquired obstruction may be primary/idiopathic or secondary to a wide variety of infectious, inflammatory, traumatic, mechanical, toxic or neoplastic causes mimicking idiopathic inflammation. These cases are treated by dacryocystorhinostomy (DCR). METHODS The present study was conducted to determine the histopathologic, immunohistochemical and current microbiologic characteristics of lacrimal sac specimens in patients undergoing external dacryocystorhinostomy. RESULTS Non-specific lacrimal sac pathology was present in all 33 cases and 81.8% of the cases showed moderate chronic inflammation with a chronic inflammatory score (CIS) ranging between 4 and 6, whereas 12.12% showed severe inflammatory changes with a CIS of 7. Mild degree of inflammation was seen in 6.06% with a CIS of 3. The total prevalence of gram-positive, gram-negative, and culture-negative samples were 59.4%, 37.5%, and 3% respectively. CONCLUSION Non-specific chronic inflammation with fibrosis is indeed the most commonly reported histopathological finding in lacrimal sac wall biopsy specimens. PMID:24392331

Amin, Rowayda Mahmoud; Hussein, Faten Aly; Idriss, Hisham Farouk; Hanafy, Nesrine Fathy; Abdallah, Dina Mohamed

2013-01-01

393

Papillary tumor of the pineal region  

PubMed Central

Presented is a patient with papillary tumor of the pineal region (PTPR), an uncommon and recently recognized neoplasm. As its name implies, PTPR does not arise from the pineal gland itself. The cell of origin is thought to be the specialized ependymocytes of the subcommissural organ. Primary tumors of the pineal region include pineal parenchymal neoplasms, germ cell neoplasms, and tumors arising from adjacent structures, including meningiomas, astrocytomas, and ependymomas. Like other masses in this location, PTPR often leads to obstructive hydrocephalus. Due to the relative paucity of reported cases of PTPR, its natural history is unknown. PMID:22275792

Opatowsky, Michael; O'Rourke, Brian; Layton, Kennith

2012-01-01

394

New insights into the functional roles of reactive oxygen species during embryo sac development and fertilization in Arabidopsis thaliana  

PubMed Central

Previously considered as toxic by-products of aerobic metabolism, reactive oxygen species (ROS) are emerging as essential signaling molecules in eukaryotes. Recent evidence showed that maintenance of ROS homeostasis during female gametophyte development is crucial for embryo sac patterning and fertilization. Although ROS are exclusively detected in the central cell of mature embryo sacs, the study of mutants deficient in ROS homeostasis suggests that controlled oxidative bursts might take place earlier during gametophyte development. Also, a ROS burst that depends on pollination takes place inside the embryo sac. This oxidative response might be required for pollen tube growth arrest and for sperm cell release. In this mini-review, we will focus on new insights into the role of ROS during female gametophyte development and fertilization. Special focus will be made on the mitochondrial Mn-Superoxide dismutase (MSD1), which has been recently reported to be essential for maintaining ROS homeostasis during embryo sac formation. PMID:23887494

Martin, Maria Victoria; Distefano, Ayelen Mariana; Zabaleta, Eduardo Julian; Pagnussat, Gabriela Carolina

2013-01-01

395

New insights into the functional roles of reactive oxygen species during embryo sac development and fertilization in Arabidopsis thaliana.  

PubMed

Previously considered as toxic by-products of aerobic metabolism, reactive oxygen species (ROS) are emerging as essential signaling molecules in eukaryotes. Recent evidence showed that maintenance of ROS homeostasis during female gametophyte development is crucial for embryo sac patterning and fertilization. Although ROS are exclusively detected in the central cell of mature embryo sacs, the study of mutants deficient in ROS homeostasis suggests that controlled oxidative bursts might take place earlier during gametophyte development. Also, a ROS burst that depends on pollination takes place inside the embryo sac. This oxidative response might be required for pollen tube growth arrest and for sperm cell release. In this mini-review, we will focus on new insights into the role of ROS during female gametophyte development and fertilization. Special focus will be made on the mitochondrial Mn-Superoxide dismutase (MSD1), which has been recently reported to be essential for maintaining ROS homeostasis during embryo sac formation. PMID:23887494

Martin, María Victoria; Distéfano, Ayelén Mariana; Zabaleta, Eduardo Julián; Pagnussat, Gabriela Carolina

2013-10-01

396

Effects of the air sac thickness on ventilation by a 1D model of an avian respiratory system.  

PubMed

Airflow in an avian respiratory system was simulated to study why birds affected with airsacculitis have respiratory distress. The airflow in the avian lung was modeled with a 1D electrical circuit and simulated for investigating what effect an increase in wall thickness of air sacs caused by airsacculitis has on flow in lung. The results demonstrated that thickening of the air sac wall caused anti-synchronization between an elastic recoiling force of the air sac walls and an intra-pleural pressure, bringing difficulties in expansion of air sacs to draw in airs during an inspiration period and thereby decreasing air to be pumped out during an expiration period. This was reflected in a decrease in air flow volume in parabronchi where gas exchange takes place. Therefore, it was concluded that airsacculitis causes imbalance in air flow dynamics in the avian lung and thus impairs breathing ability of birds. PMID:24109723

Urushikubo, Akira; Nakamura, Masanori; Hirahara, Hiroyuki

2013-01-01

397

Expression of OCT4 in the primary germ cell tumors and thymoma in the mediastinum.  

PubMed

Primary germ cell tumors (GCTs) and thymoma are both located in the anterior mediastinum. A previous study has postulated that octamer binding transcription factor (OCT4) is a nuclear transcription factor that is expressed in pluripotent embryonic germ cells. This study examined OCT4 expression in GCTs and thymoma originating from the mediastinum. A retrospective study included 46 consecutive patients with GCTs conducted between 1983 and 2005, and 22 consecutive thymoma in the mediastinum whose tumors had been surgically excised. The 46 primary GCTs in mediastinum included teratoma (n=27; 58.7%), seminoma (n=10; 21.7%), yolk sac tumor (n=6; 13%), embryonal carcinoma (n=1; 2.1%), and mixed GCTs (n=2; 4%; one consisted of teratoma and yolk sac tumor, and the other teratoma, yolk sac tumor, and seminoma); and 22 thymoma including World Health Organization type A (n=3, 13.6%), type AB (n=4, 18.2%), type B1 (n=6, 27.3%), type B2 (n=4, 13.6%), and type B3 (n=5, 22.7%). Each tumor was examined with hematoxylin and eosin staining, and with antibodies to OCT4. All 10 seminoma cases, 1 embryonal carcinoma case, and 1 mixed GCT case containing seminoma were immunopositive for OCT4. On the other hand, the 22 thymoma, 6 yolk sac tumor, 27 teratomas, and 1 case with mixed GCT without component of seminoma were immunonegative for OCT4. We conclude that immunostaining with antibodies to OCT4 is a useful diagnostic tool in the identification of seminomas and primary embryonal carcinomas in GCTs originating from the mediastinum. PMID:16932017

Jung, Shih-Ming; Chu, Pao-Hsien; Shiu, Tzu-Fang; Wu, Hsueh-Hua; Kuo, Tseng-Tong; Chu, Jaw-Ji; Lin, Pyng-Jing

2006-09-01

398

An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine  

Microsoft Academic Search

Summary  An improved everted gut sac system has been developed in which the sacs were carefully prepared from rat small intestine and\\u000a incubated in tissue culture medium. Under these conditions, the tissue showed good morphology at the electron microscope level,\\u000a and was metabolically active for up to 2 h at 37° C. Mannitol, an established probe of paracellular transport, was transported

L. BARTHEl; J. F. Woodley; S. Kenworthy; G. Houin

1998-01-01

399

The role of quail bronchitis virus as a possible precipitating factor in "air sac syndrome" of chickens  

E-print Network

THE ROLE OF QUAIL BRONCHITIS VIRUS AS A POSSIBLE PRECIPITATING FACTOR IN "AIR SAC SYNDROME" OF CHICKENS A Thesis By JERRY BOB PAYNE Submitted to the Graduate College of the Texas ARM University in partfal fulfillment of the requirements... for the degree of MASTER OF SCIENCE January 1965 Major Subject: Veterinary Microbiology THE ROLE OF QUAIL BRONCHITIS VIRUS AS A POSSIBLE PRECIPITATING FACTOR IN "AIR SAC SYNDROME" OF CHICKENS A Thesis By JERRY BOB PAYNE Approved as to style and dontent...

Payne, Jerry Bob

2012-06-07

400

Brain tumors.  

PubMed Central

Recent advances in experimental tumor biology are being applied to critical clinical problems of primary brain tumors. The expression of peripheral benzodiazepine receptors, which are sparse in normal brain, is increased as much as 20-fold in brain tumors. Experimental studies show promise in using labeled ligands to these receptors to identify the outer margins of malignant brain tumors. Whereas positron emission tomography has improved the dynamic understanding of tumors, the labeled selective tumor receptors with positron emitters will enhance the ability to specifically diagnose and greatly aid in the pretreatment planning for tumors. Modulation of these receptors will also affect tumor growth and metabolism. Novel methods to deliver antitumor agents to the brain and new approaches using biologic response modifiers also hold promise to further improve the management of brain tumors. Images PMID:1848735

Black, K. L.; Mazziotta, J. C.; Becker, D. P.

1991-01-01

401

Ultrastructure of the endolymphatic sac in the larva of the japanese red-bellied newt Cynops pyrrhogaster  

NASA Technical Reports Server (NTRS)

The ultrastructure of the endolymphatic sac (ES) of the late stage larva of the Japanese red-bellied newt, Cynops pyrrhogaster (stage 57), was examined by light and transmission electron microscopy. The two endolymphatic sacs are located at the dorsal-medial side of the otic vesicle on the dorsal-lateral side of the midbrain in the cranial cavity. The wall of the sac is composed of a layer of cubical epithelial cells with loose, interposed intercellular spaces. The sac contains a large luminal cavity, in which endolymph and numerous otoconia are present. The epithelial cells of different portions of the sac have a similar structure. These cells contain an abundance of cytoplasmic organelles, including ribosomes, Golgi complexes, and numerous vesicles. Two types of vesicles are found in the epithelial cells: the "floccular" vesicle and the "granular" vesicle. The floccular vesicles are located in the supra- and lateral-nuclear cytoplasm and contain floccular material. The granular vesicles have a fine granular substance and are usually situated apposed to the apical cell membrane. The granular vesicles are suggested to be secreted into the lumen, while the floccular vesicles are thought to be absorbed from the lumen and conveyed to the intercellular spaces by the epithelial cells. The apical surfaces of the epithelial cells bear numerous microvilli. Apparently floating cells, which bear long microvilli on the free surfaces, are observed in the lumen of the ES. Based on the fine structure, the function of the endolymphatic sac of the newt Cynops pyrrhogaster is discussed.

Gao, W.; Wiederhold, M.; Hejl, R.

1998-01-01

402

Castor sacs and anal glands of the north american beaver (Castor canadensis): their histology, development, and relationship to scent communication.  

PubMed

Both sexes of beavers possess a pair of castor sacs and a pair of anal glands located in paired subcutaneous cavities between the pelvis and the base of the tail. The castor sacs are not glandular in the histological sense, hence references to these structures as preputial glands or castor glands are misnomers. The wall of the castor sacs is plicate and comprised of three distinct zones: an outer layer of vascular connective tissue, a two-to five-cell-thick layer of mitotic epithelial cells, and several densely packed layers of cornified epithelium which grade into more widely separated sheets toward the lumen. Monocultures of a gram-positive facultatively anaerobic bacterium were present in the lumen of all castor sac preparations. Differences in the frequency of castoreum deposition were not attributable to differences in the structure of the castor sacs. The anal glands of beavers are holocrine sebaceous glands. These glands develop more rapidly than the castor sacs. Anal gland tissue from embryos exhibited cellular characteristics associated with the production of sebum. Secretory activity was evident in all preparations. The relationship of castoreum and anal gland secretion to scent communication among beavers is discussed. PMID:24415179

Walro, J M; Svendsen, G E

1982-05-01

403

Influencing Factors for Abdominal Aortic Aneurysm Sac Shrinkage and Enlargement after EVAR: Clinical Reviews before Introduction of Preoperative Coil Embolization  

PubMed Central

Background: We previously reported effectiveness of coil embolization (CE) to aortic branched vessels before endovascular aortic repair (EVAR) for abdominal aortic aneurysm (AAA) because of significant shrinkage of aneurysmal sac. In this study, we investigated EVAR cases to clarify influential factors of aneurysmal shrinkage and enlargement. Methods: 148 consecutive cases before the introduction of CE were retrospectively reviewed based on the presence of PT2EL (persistent type 2 endoleak) and change in sac diameter after EVAR by multivariate analysis. Results: (A) PT2EL risk factors were patent inferior mesenteric artery (IMA) and thinner mural thrombus inside aneurysmal sac. (B) Sac enlargement risk factors were antiplatelet intake, PT2EL, and female gender. (C) Sac shrinkage predictive factors were the absences of thoracic aortic aneurysm, antiplatelet intake, PT2EL, and coronary artery disease. Conclusion: CE to IMA was considered to be effective because patent IMA and antiplatelet intake were significant risk factors for sac enlargement. So, more meticulous therapeutic strategy, including treatment priority (AAA first or CAD first) and choice of treatment (EVAR vs. AAA) based on anatomical features of AAA was required to improve late outcomes. PMID:25298830

Hiraoka, Arudo; Totsugawa, Toshinori; Tamura, Kentaro; Ishida, Atsuhisa; Sakaguchi, Taichi; Yoshitaka, Hidenori

2014-01-01

404

Monopolar Spindle 1 (MPS1) Protein-dependent Phosphorylation of RecQ-mediated Genome Instability Protein 2 (RMI2) at Serine 112 Is Essential for BLM-Topo III ?-RMI1-RMI2 (BTR) Protein Complex Function upon Spindle Assembly Checkpoint (SAC) Activation during Mitosis*  

PubMed Central

Genomic instability and a predisposition to cancer are hallmarks of Bloom syndrome, an autosomal recessive disease arising from mutations in the BLM gene. BLM is a RecQ helicase component of the BLM-Topo III ?-RMI1-RMI2 (BTR) complex, which maintains chromosome stability at the spindle assembly checkpoint (SAC). Other members of the BTR complex include Topo IIIa, RMI1, and RMI2. All members of the BTR complex are essential for maintaining the stable genome. Interestingly, the BTR complex is posttranslationally modified upon SAC activation during mitosis, but its significance remains unknown. In this study, we show that two proteins that interact with BLM, RMI1 and RMI2, are phosphorylated upon SAC activation, and, like BLM, RMI1, and RMI2, are phosphorylated in an MPS1-dependent manner. An S112A mutant of RMI2 localized normally in cells and was found in SAC-induced coimmunoprecipitations of the BTR complex. However, in RMI2-depleted cells, an S112A mutant disrupted the mitotic arrest upon SAC activation. The failure of cells to maintain mitotic arrest, due to lack of phosphorylation at Ser-112, results in high genomic instability characterized by micronuclei, multiple nuclei, and a wide distribution of aberrantly segregating chromosomes. We found that the S112A mutant of RMI2 showed defects in redistribution between the nucleoplasm and nuclear matrix. The phosphorylation at Ser-112 of RMI2 is independent of BLM and is not required for the stability of the BTR complex, BLM focus formation, and chromatin targeting in response to replication stress. Overall, this study suggests that the phosphorylation of the BTR complex is essential to maintain a stable genome. PMID:24108125

Pradhan, Arun; Singh, Thiyam Ramsing; Ali, Abdullah Mahmood; Wahengbam, Kebola; Meetei, Amom Ruhikanta

2013-01-01

405

Adenocarcinoma arising from an anal gland--Report of a case  

PubMed Central

INTRODUCTION Adenocarcinoma arising from an anal gland is extremely rare. Most anal canal cancers are squamous cell carcinoma, and adenocarcinoma is infrequently diagnosed. Diagnostic criteria and the standard treatment for adenocarcinoma of the anal canal have not been clearly defined, in part because of the rarity of this lesion. PRESENTATION OF CASE An 84-year-old man who presented with a piece of tissue prolapsing from the anus. An incisional biopsy showed adenocarcinoma, and an abdomino-perineal resection was then performed. Cytokeratin 7 (CK7), cytokeratin 19 (CK19) stained positive in the specimen, suggesting that the tumor developed from an anal gland. The patient was discharged after surgery without any complications. DISCUSSION Exact diagnostic criteria for adenocarcinoma of the anal canal have not been previously described. In the present case, CK7 and CK19 were stained, and the tumor showed positivity for both of these markers, which is compatible with the staining patterns of anal gland origin cancer. Radical resection is recommended rather than local resection, because of the tumor's high recurrence rate. Some authors recommend combined modality treatment with preoperative or postoperative chemoradiotherapy because of the high rate of distant recurrence. CONCLUSION The preoperative diagnosis of adenocarcinoma arising from an anal gland is not easily established. However, it may be possible to suspect an anal glandular adenocarcinoma based on a meticulous physical examination, appropriate diagnostic studies and pathological findings on biopsy. PMID:24705191

Sakamoto, Takashi; Konishi, Fumio; Yoshida, Takayoshi; Yoshinaga, Yasuo; Izumo, Toshiyuki; Lefor, Alan

2014-01-01

406

Angiosarcoma arising from the tongue of an 11-year-old girl with xeroderma pigmentosum.  

PubMed

Xeroderma pigmentosum (XP) is a rare autosomal recessive defect in DNA endonuclease activity that is associated with the development of cutaneous malignancies, at sun exposed sites, including basal cell carcinoma, squamous cell carcinoma, and melanoma. Squamous cell carcinomas are also known to target the anterior tongue. Patients sometimes develop angiosarcomas, and these invariably arise from sun-exposed skin. A biopsy was taken from a large mass arising in the anterior tongue of an 11-year-old girl with XP and a history of cutaneous basal cell carcinomas. The histopathologic findings demonstrated a high grade epithelioid neoplasm resembling a poorly differentiated squamous cell carcinoma, but the immunohistochemical profile (AE1/AE3 negative, p63 negative, CD31 positive, CD34 positive) established the diagnosis of angiosarcoma. Angiosarcoma is an XP-related tumor that usually arises in sun-exposed skin but can also arise in the oral cavity. For patients with XP who develop epithelioid neoplasms of the oral cavity, epithelioid angiosarcoma should be considered in the differential diagnosis. PMID:21987224

Olson, Matthew T; Puttgen, Katherine B; Westra, William H

2012-06-01

407

Bone Tumor  

MedlinePLUS

... Some tumors may come back, even repeatedly, a er appropriate treatment. Malignant Tumors Limb Salvage Surgery This ... implants. This allows better function and durability a er limb salvage surgery. Advancements in the development of ...

408

Gastric Cancer Arising from an Upside-Down Stomach through a Paraesophageal Hiatal Hernia  

PubMed Central

We report the rare case of an elderly patient with an advanced gastric cancer arising from an upside-down stomach through a paraesophageal hiatal hernia (PEH). An 82-year-old man presented with appetite loss and anemia. Upper gastrointestinal endoscopy revealed a type 1 tumor located in the middle body of the stomach. An upper gastrointestinal series and computed tomography showed organoaxial rotation of the stomach, which was located in the mediastinum, through a PEH, indicating an upside-down stomach. The preoperative diagnosis was gastric cancer arising from an upside-down stomach through a PEH. The patient underwent total gastrectomy with lymph node dissection and closure of the hernial orifice. Although a large PEH is a chronic disorder, gastric malignancies should be considered in patients with PEH manifested as an upside-down stomach due to its anatomical characteristics, and careful preoperative diagnosis is mandatory. PMID:24761138

Mimatsu, Kenji; Kano, Hisao; Oida, Takatsugu; Kawasaki, Atsushi; Fukino, Nobutada; Kida, Kazutoshi; Kuboi, Youichi; Amano, Sadao

2014-01-01

409

Clinical experience in ovarian squamous cell carcinoma arising from mature cystic teratoma: A rare entity  

PubMed Central

Objective We sought to investigate the clinicopathologic features of ovarian squamous cell carcinomas arising from mature cystic teratomas (MCT) and to report our clinical experience and lessons learned. Methods From January 1993 to November 2012, a total of 6,260 women with ovarian MCT were surgically treated at Cheil General Hospital and Women's Healthcare Center. Among them, the cases with malignant transformation to squamous cell carcinoma were included in this analysis. Patient demographic characteristics, surgical findings, and prognosis were evaluated retrospectively. Results Of the 6,260 ovarian MCT patients, four (0.06%) had ovarian squamous cell carcinoma arising from MCT. The mean patient age was 43 years (range, 35-51 years), and the mean tumor size was 12 cm (range, 9-16 cm), with two patients in the International Federation of Gynecology and Obstetrics stage I and the other two in stage III. Upon preoperative imaging, all cases were expected to be benign ovarian tumors, but the preoperative squamous cell carcinoma antigen level was elevated from 1.5 ng/mL in stage Ia to 11.3 ng/mL in stage IIIc, suggesting malignancy, while the CA-125 level was normal in two of the three patients who received the test. Optimal debulking surgery was performed and adjuvant chemotherapy was used in all patients, but death from the recurrence of disease occurred in one patient, whose overall survival was 10 months. Conclusion Ovarian squamous cell carcinoma arising from MCT is extremely rare, and it is rarely diagnosed preoperatively on imaging workups. Measuring the squamous cell carcinoma antigen level might be a useful diagnostic clue, and it might also be predictive of the tumor stage. An adequate staging surgery should be included in the standard treatment, but multicenter studies are needed to confirm this. PMID:25105100

Choi, Eun-Jeong; Koo, Yu-Jin; Jeon, Ji-Hyun; Kim, Tae-Jin; Lee, Ki-Heon

2014-01-01

410

LMI optimization for nonstandard Riccati equations arising in stochastic control  

Microsoft Academic Search

We consider coupled Riccati equations that arise in the optimal control of jump linear systems. We show how to reliably solve these equations using convex optimization over linear matrix inequalities (LMIs). The results extend to other nonstandard Riccati equations that arise, e.g., in the optimal control of linear systems subject to state-dependent multiplicative noise. Some nonstandard Riccati equations (such as

Mustapha Ait-rami; Laurent El Ghaoui

1996-01-01

411

Spitz nevus arising upon a congenital glomuvenous malformation.  

PubMed

There are several reports of the collision of vascular and pigmentary anomalies (e.g., phakomatosis pigmentovascularis) and the association between congenital melanocytic nevi and infantile hemangiomas. We report a case of Spitz nevus arising in skin overlying a congenital plaque-like glomuvenous malformation (GVM). This is the first report of a Spitz nevus arising in direct contiguity to a GVM. PMID:22304367

Arica, Deniz A; Arica, Ibrahim E; Yayli, Savas; Cobanoglu, Umit; Akay, Bengu N; Anadolu, Rana; Bahadir, Sevgi

2013-01-01

412

Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs)  

SciTech Connect

Highlights: {yields} Endothelin-1 expression by adult rat astrocytes correlates with cell proliferation. {yields} Stretch-induced ET-1 is inhibited by GsMtx-4, a specific inhibitor of Ca{sup 2+} permeant SACs. {yields} The less specific SAC inhibitor streptomycin also inhibits ET-1 secretion. {yields} Stretch-induced ET-1 production depends on a calcium influx. {yields} SAC pharmacology may provide a new class of therapeutic agents for CNS pathology. -- Abstract: The expression of endothelins (ETs) and ET-receptors is often upregulated in brain pathology. ET-1, a potent vasoconstrictor, also inhibits the expression of astrocyte glutamate transporters and is mitogenic for astrocytes, glioma cells, neurons, and brain capillary endothelia. We have previously shown that mechanical stress stimulates ET-1 production by adult rat astrocytes. We now show in adult astrocytes that ET-1 production is driven by calcium influx through stretch-activated ion channels (SACs) and the ET-1 production correlates with cell proliferation. Mechanical stimulation using biaxial stretch (<20%) of a rubber substrate increased ET-1 secretion, and 4 {mu}M GsMTx-4 (a specific inhibitor of SACs) inhibited secretion by 30%. GsMTx-4 did not alter basal ET-1 levels in the absence of stretch. Decreasing the calcium influx by lowering extracellular calcium also inhibited stretch-induced ET-1 secretion without effecting ET-1 secretion in unstretched controls. Furthermore, inhibiting SACs with the less specific inhibitor streptomycin also inhibited stretch-induced ET-1 secretion. The data can be explained with a simple model in which ET-1 secretion depends on an internal Ca{sup 2+} threshold. This coupling of mechanical stress to the astrocyte endothelin system through SACs has treatment implications, since all pathology deforms the surrounding parenchyma.

Ostrow, Lyle W., E-mail: lostrow1@jhmi.edu [Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205 (United States); Suchyna, Thomas M.; Sachs, Frederick [Department of Physiology and Biophysical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States)] [Department of Physiology and Biophysical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States)

2011-06-24

413

Squamous cell carcinoma arising from longstanding colocutaneous fistula: a case report.  

PubMed

A 60-year-old female patient suffered unhealed wounds over left flank for around 30 years after surgical removal of left renal stones. Fecal material spilled from the two small openings of the scar, bothered her all day long. During the course of the 30 years, she suffered from intermittent fever, diarrhea and wound pain and presented with malnourished condition. After serial examinations, tumor associated with iatrogenic colo-cutaneous fistula was impressed and she received en bloc resection. Pathology revealed squamous cell carcinoma arising from the fistula with colon and spleen invasion. To the best of our knowledge, no such case has been reported, as yet. PMID:16127766

Lee, Yueh-Tsung; Hsu, Sheng-Der; Kuo, Chien-Long; Chou, Dev-Aur; Lin, Mao-Sheng; Huang, Min-Ho; Wu, Hurng-Sheng

2005-09-01

414

Water quality in the Little Sac River basin near Springfield, Missouri, 1999-2001  

USGS Publications Warehouse

The Little Sac River, north of Springfield, Missouri, flows through mainly agricultural and forest land. However, the quality of the river water is a concern because the river flows into Stockton Lake, which is a supplemental drinking water source for Springfield. Large bacterial densities and nutrient concentrations are primary concerns to the water quality of the river.A 29-river mile reach of the Little Sac River is on the 1998 list of waters of Missouri designated under section 303(d) of the Federal Clean Water Act because of fecal coliform densities larger than the Missouri Department of Natural Resources standard (hereinafter referred to as Missouri standard) of 200 colonies per 100 milliliters for whole-body contact recreation. During an investigation of the water quality in the Little Sac River by the U.S. Geological Survey, in cooperation with the Watershed Committee of the Ozarks, fecal coliform bacteria densities exceeded the Missouri standard (the standard applies from April 1 through October 31) in one sample from a site near Walnut Grove. At other sites on the Little Sac River, the Missouri standard was exceeded in two samples and equalled in one sample upstream from the Northwest Wastewater Treatment Plant (NW WTP) and in one sample immediately downstream from the NW WTP.Effluent from the NW WTP flows into the Little Sac River. Annually from April 1 through October 31, the effluent is disinfected to meet the Missouri standard for whole-body contact recreation. Fecal coliform bacteria densities in samples collected during this period generally were less than 100 colonies per 100 milliliters. For the rest of the year when the effluent was not disinfected, the bacteria densities in samples ranged from 50 (sample collected on November 1, 2000) to 10,100 colonies per 100 milliliters (both counts were non-ideal). When the effluent was disinfected and the fecal coliform bacteria density was small, samples from sites upstream and downstream from the NW WTP had a bacteria density larger than the density in the effluent. Other sources of bacteria are likely to be present in the study area in addition to the NW WTP. These potential sources include effluent from domestic septic systems and animal wastes.Nutrient concentrations in the Little Sac River immediately downstream from the NW WTP were affected by effluent from the NW WTP and possibly other sources. At two sites upstream from the NW WTP, median nitrite plus nitrate concentrations were 1.1 and 1.4 milligrams per liter. The median nitrite plus nitrate concentration for the effluent from the NW WTP was 6.4 milligrams per liter, and the median concentration decreased downstream in the Little Sac River to 2.2, 1.2, and 0.56 milligrams per liter.The effects of the effluent from the NW WTP on the water quality of the Little Sac River downstream from the NW WTP were reflected in an increase in discharge (effluent from the NW WTP can be as much as 50 percent of the flow at the site about 1.5 river miles downstream from the NW WTP), an increase in specific conductance values, an increase in several inorganic constituent concentrations, including calcium, magnesium, and sulfate, and a large increase in sodium and chloride concentrations. The effluent from the NW WTP seemed to have no effect on the pH value, temperature, and dissolved oxygen concentrations in the Little Sac River.Results of repetitive element polymerase chain reaction (rep-PCR) pattern analysis indicated that most Escherichia coli (E. coli) bacteria in water samples probably were from nonhuman sources, such as horses and cattle. The rep-PCR pattern analysis indicated that horses were an important source of E. coli downstream from the NW WTP, which was consistent with horses pastured adjacent to the sampling site. Fecal coliform bacteria loads increased upstream from the NW WTP from the most upstream site to the site immediately upstream from the NW WTP. Loads in the effluent from the NW WTP and also tho

Smith, Brenda J.

2002-01-01

415

Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.  

PubMed

PiT-1 protein is a transmembrane sodium-dependent phosphate (Pi) transporter. PiT-1 knock out (KO) embryos die from largely unknown causes by embryonic day (E) 12.5. We tested the hypothesis that PiT-1 is required for endocytosis in the embryonic yolk sac (YS) visceral endoderm (VE). Here we present data supporting that PiT-1 KO results in a YS remodeling defect and decreased endocytosis in the YS VE. The remodeling defect is not due to an upstream cardiomyocyte requirement for PiT-1, as SM22?Cre-specific KO of PiT-1 in the developing heart and the YS mesodermal layer (ME) does not recapitulate the PiT-1 global KO phenotype. Furthermore, we find that high levels of PiT-1 protein localize to the YS VE apical membrane. Together these data support that PiT-1 is likely required in YS VE. During normal development maternal immunoglobulin (IgG) is endocytosed into YS VE and accumulates in the apical side of the VE in a specialized lysosome termed the apical vacuole (AV). We have identified a reduction in PiT-1 KO VE cell height and a striking loss of IgG accumulation in the PiT-1 KO VE. The endocytosis genes Tfeb, Lamtor2 and Snx2 are increased at the RNA level. Lysotracker Red staining reveals a loss of distinct AVs, and yolk sacs incubated ex vivo with phRODO Green Dextran for Endocytosis demonstrate a functional loss of endocytosis. As yolk sac endocytosis is controlled in part by microautophagy, but expression of LC3 had not been examined, we investigated LC3 expression during yolk sac development and found stage-specific LC3 RNA expression that is predominantly from the YS VE layer at E9.5. Normalized LC3-II protein levels are decreased in the PiT-1 KO YS, supporting a requirement for PiT-1 in autophagy in the YS. Therefore, we propose the novel idea that PiT-1 is central to the regulation of endocytosis and autophagy in the YS VE. PMID:25138534

Wallingford, Mary C; Giachelli, Cecilia M

2014-08-01

416

Early sac shrinkage predicts a low risk of late complications after endovascular aortic aneurysm repair  

PubMed Central

Background Aneurysm shrinkage has been proposed as a marker of successful endovascular aneurysm repair (EVAR). Patients with early postoperative shrinkage may experience fewer subsequent complications, and consequently require less intensive surveillance. Methods Patients undergoing EVAR from 2000 to 2011 at three vascular centres (in 2 countries), who had two imaging examinations (postoperative and after 6–18 months), were included. Maximum diameter, complications and secondary interventions during follow-up were registered. Patients were categorized according to early sac dynamics. The primary endpoint was freedom from late complications. Secondary endpoints were freedom from secondary intervention, postimplant rupture and direct (type I/III) endoleaks. Results Some 597 EVARs (71·1 per cent of all EVARs) were included. No shrinkage was observed in 284 patients (47·6 per cent), moderate shrinkage (5–9 mm) in 142 (23·8 per cent) and major shrinkage (at least 10 mm) in 171 patients (28·6 per cent). Four years after the index imaging, the rate of freedom from complications was 84·3 (95 per cent confidence interval 78·7 to 89·8), 88·1 (80·6 to 95·5) and 94·4 (90·1 to 98·7) per cent respectively. No shrinkage was an independent risk factor for late complications compared with major shrinkage (hazard ratio (HR) 3·11; P < 0·001). Moderate compared with major shrinkage (HR 2·10; P = 0·022), early postoperative complications (HR 3·34; P < 0·001) and increasing abdominal aortic aneurysm baseline diameter (HR 1·02; P = 0·001) were also risk factors for late complications. Freedom from secondary interventions and direct endoleaks was greater for patients with major sac shrinkage. Conclusion Early change in aneurysm sac diameter is a strong predictor of late complications after EVAR. Patients with major sac shrinkage have a very low risk of complications for up to 5 years. This parameter may be used to tailor postoperative surveillance. PMID:24752772

Bastos Goncalves, F; Baderkhan, H; Verhagen, H J M; Wanhainen, A; Bjorck, M; Stolker, R J; Hoeks, S E; Mani, K

2014-01-01

417

Yolk sac endoderm: exclusive site of serum protein synthesis in the early chick embryo  

SciTech Connect

In order to determine which cell type or types synthesized serum proteins, yolk sacs from 4-day chick embryos were manually separated into ectoderm, mesoderm, and endoderm and incubated in the presence of radioactive valine. Analysis of the incubation media by polyacrylamide gel electrophoresis as well as by immunoprecipitation showed that all serum proteins were synthesized exclusively by the cells of the endoderm. These included transferrin and three embryo-specific serum proteins: ..cap alpha..reverse arrowglobulin ..cap alpha..-globulin b, and prealbumin.

Young, M.F.; Minghetti, P.P.; Klein, N.W.

1980-01-01

418

Anal sac secretion of the red fox, Vulpes vulpes ; volatile fatty acids and diamines: Implications for a fermentation hypothesis of chemical recognition  

Microsoft Academic Search

Putrescine (1,4-diaminobutane) and cadaverine (1,5-di-aminopentane) were identified in the anal sac secretions of the red fox,Vulpes vulpes, and of the lion, Panthera leo. Anal sac secretion samples obtained over a period of 10 weeks by sampling from within each sac of each of 6 captive foxes were analyzed and putrescine, cadaverine, and volatile fatty acid compositions and secretion pH values

E. S. Albone; G. C. Perry

1976-01-01

419

An Equivalence Theorem for the Specification of Asynchronous Communication Systems (SACS) and Asynchronous Message Passing System (AMPS)  

NASA Astrophysics Data System (ADS)

Formal semantics have been employed in the specification and verification of programming languages. Language for Implementing Parallel/distributed Systems (LIPS) is an asynchronous message passing parallel programming language which handles communication and computation parts independently. The communication part of LIPS can be specified using a process algebraic tool, Specification of Asynchronous Communication Systems (SACS), and is implemented using Asynchronous Message Passing System (AMPS). An implementation is said to be complete only when we prove that it meets its specifications. To achieve that we need to prove an equivalence relation between a program's specification and its implementation. This means that it is necessary to study the proof of equivalence of SACS and AMPS to prove the completeness of AMPS. The semantics of both SACS and AMPS have been defined using Structural Operational Semantics (SOS) in terms of Labelled Transition Systems (LTS). So we have two labelled transition system semantics : one for SACS and one for AMPS. In this paper we are proving the bisimilarity of these two labelled transition systems to prove that SACS and AMPS are equivalent.

Rajan, A. V. S.; Bavan, A. S.; Abeysinghe, G.

420

Enhancement of Processability and Electrical Resistance by Use of Ag-Based Composite Inks Containing Ultrafine SAC305 Alloy Nanoparticles  

NASA Astrophysics Data System (ADS)

We propose use of Ag/Sn-3.0 (wt.%) Ag-0.5 Cu (SAC305) composite ink to reduce sintering temperature, sintering time, and material costs. The SAC305 nanoparticle (NP) surfaces were not capped by any stabilizers, which are detrimental to the resistivity of the sintered tracks. Compared with commercial pure Ag ink, use of Ag/3.2 (vol.%) SAC305 composite ink containing ultrafine SAC305 NPs resulted in outstandingly enhanced processability, enabling faster sintering at low temperatures. The average sheet resistance of composite ink samples sintered for 25 min at 170°C was as low as 0.011 ?/?, comparable with that of a pure Ag sample sintered for over 30 min at 220°C. The morphology and the differential scanning calorimetry curves enabled explanation of the changes in the sintering behavior and sheet resistance. The Ag/SAC305 clusters in the composite ink sintered at 170°C grew, on average, to ~201.1-226.1 nm as a result of faster local liquid-phase sintering, and most of the Ag particles were mutually linked, dramatically changing the microstructure.

Shin, Yong Moo; Kim, Hyun-Jin; Jang, Seok Pil; Lee, Jong-Hyun

2014-09-01

421

Primary tumors of the spine.  

PubMed

Spinal tumors consist of a large spectrum of various histologic entities. Multiple spinal lesions frequently represent known metastatic disease or lymphoproliferative disease. In solitary lesions primary neoplasms of the spine should be considered. Primary spinal tumors may arise from the spinal cord, the surrounding leptomeninges, or the extradural soft tissues and bony structures. A wide variety of benign neoplasms can involve the spine including enostosis, osteoid osteoma, osteoblastoma, aneurysmal bone cyst, giant cell tumor, and osteochondroma. Common malignant primary neoplasms are chordoma, chondrosarcoma, Ewing sarcoma or primitive neuroectodermal tumor, and osteosarcoma. Although plain radiographs may be useful to characterize some spinal lesions, magnetic resonance imaging is indispensable to determine the extension and the relationship with the spinal canal and nerve roots, and thus determine the plan of management. In this article we review the characteristic imaging features of extradural spinal lesions. PMID:24896744

Orguc, Sebnem; Arkun, Remide

2014-07-01

422

Buckling Instability in Growing Tumor Spheroids  

NASA Astrophysics Data System (ADS)

A growing tumor is subjected to intrinsic physical forces, arising from the cellular turnover in a spatially constrained environment. This work demonstrates that such residual solid stresses can provoke a buckling instability in heterogeneous tumor spheroids. The growth rate ratio between the outer shell of proliferative cells and the inner necrotic core is the control parameter of this instability. The buckled morphology is found to depend both on the elastic and the geometric properties of the tumor components, suggesting a key role of residual stresses for promoting tumor invasiveness.

Ciarletta, P.

2013-04-01

423

Maternal-fetal immunoglobulin transport: Studies on the binding, internalization, and release of IgG by chick yolk sac tissue and cultured cells  

SciTech Connect

Immunoglobulin G (IgG) is transported from the yolk across the endodermal cells of the yolk sac and into the fetal circulation during chick embryonic development, thus providing the chick with passive immunity until it becomes immunocompetent. Saturable, Fc-specific receptors are present on the endodermal cells and are believed to mediate this transfer. In this study, IgG receptors were shown to be present on the yolk sac endodermal cells throughout the 21 days of development, although most of the transport occurs during the last 3 days prior to hatching. Fluorescently conjugated IgG was internalized by a receptor mechanism into small apical vesicles in yolk sac endoderm throughout, but cells from 19 day yolk sacs internalized more conjugate than those from 14 day yolk sacs. This was confirmed and quantitated by assaying the internalization of {sup 125}I-IgG into yolk sac tissue. IgG was internalized by a receptor mediated mechanism, reaching a steady state level after 1 to 2 hours. Although both ages of yolk sac tissue possessed the same number of surface IgG receptors, as measured by equilibrium binding assays at 4{degree}C, 19 day yolk sac had the capacity to internalize six times as much IgG by a receptor mechanism as 14 day yolk sac.

Donaldson, J.G.

1988-01-01

424

Digital PCR technology detects brain-tumor-associated mutation in cerebrospinal fluid  

Cancer.gov

Researchers from the Massachusetts General Hospital (a component of the Dana-Farber Cancer Institute) and their colleagues have used digital versions of a standard molecular biology tool to detect a common tumor-associated mutation in the cerebrospinal fluid (CSF) of patients with brain tumors. In their report being published in the open-access journal Molecular Therapy – Nucleic Acids, the investigators describe using advanced forms of the gene-amplification technology polymerase chain reaction (PCR) to analyze bits of RNA carried in membrane-covered sacs called extracellular vesicles for the presence of a tumor-associated mutation in a gene called IDH1.

425

Air Sac Nematode Monopetalonema alcedinis in a Belted Kingfisher (Megaceryle alcyon) in Maryland, USA.  

PubMed

Sporadic and geographically widespread reports of parasites affecting the Belted Kingfisher (Megaceryle alcyon) have been published but few have described details of the pathology. A female, adult kingfisher was found dead in a heavily wooded area of a zoo in Maryland, USA. At necropsy, numerous sexually dimorphic, 4.4-40.5-cm adult Monopetalonema alcedinis nematodes were found tightly wound within the coelomic cavity between organs and completely filling the caudal thoracic and abdominal air sacs. Abundant, 30-60-µm diameter, larvated, thick-walled ova were found in the bronchi and parabronchi, within the mesentery, and in the serosa of multiple coelomic organs. Monopetalonema alcedinis is a characteristic member of the superfamily Diplotriaenoidea, a group of nematodes occurring in birds and reptiles. Infective larvae within an invertebrate intermediate host are ingested and penetrate the intestine, traveling to the lungs and then into the air sacs, where the adult females release eggs. The ova are coughed up by the avian host and passed in feces. Specimens of M. alcedinis have been found in the Belted Kingfisher, although typically intensity of infection is low and infections remain asymptomatic. In contrast, we report the second documented case of high numbers of M. alcedinis resulting in pathologic changes in which parasitism contributed to host mortality. PMID:25271642

Bronson, Ellen; Kelly, Kathleen; Hoberg, Eric P

2014-10-01

426

Embryo sac formation and early embryo development in Agave tequilana (Asparagaceae).  

PubMed

Agave tequilana is an angiosperm species that belongs to the family Asparagaceae (formerly Agavaceae). Even though there is information regarding to some aspects related to the megagametogenesis of A. tequilana, this is the first report describing the complete process of megasporogenesis, megagametogenesis, the early embryo and endosperm development process in detail. The objective of this work was to study and characterize all the above processes and the distinctive morphological changes of the micropylar and chalazal extremes after fertilization in this species. The agave plant material for the present study was collected from commercial plantations in the state of Jalisco, Mexico. Ovules and immature seeds, previously fixed in FAA and kept in ethanol 70%, were stained based on a tissue clarification technique by using a Mayer's-Hematoxylin solution. The tissue clarification technique was successfully used for the characterization of the megasporogenesis, megagametogenesis, mature embryo sac formation, the early embryo and endosperm development processes by studying intact cells. The embryo sac of A. tequilana was confirmed to be of the monosporic Polygonum-type and an helobial endosperm formation. Also, the time-lapse of the developmental processes studied was recorded. PMID:25332875

González-Gutiérrez, Alejandra G; Gutiérrez-Mora, Antonia; Rodríguez-Garay, Benjamín

2014-01-01

427

Comparative Analysis and Functional Mapping of SACS Mutations Reveal Novel Insights into Sacsin Repeated Architecture  

PubMed Central

Autosomal recessive spastic ataxia of Charlevoix–Saguenay (ARSACS) is a neurological disease with mutations in SACS, encoding sacsin, a multidomain protein of 4,579 amino acids. The large size of SACS and its translated protein has hindered biochemical analysis of ARSACS, and how mutant sacsins lead to disease remains largely unknown. Three repeated sequences, called sacsin repeating region (SRR) supradomains, have been recognized, which contribute to sacsin chaperone-like activity. We found that the three SRRs are much larger (?1,100 residues) than previously described, and organized in discrete subrepeats. We named the large repeated regions Sacsin Internal RePeaTs (SIRPT1, SIRPT2, and SIRPT3) and the subrepeats sr1, sr2, sr3, and srX. Comparative analysis of vertebrate sacsins in combination with fine positional mapping of a set of human mutations revealed that sr1, sr2, sr3, and srX are functional. Notably, the position of the pathogenic mutations in sr1, sr2, sr3, and srX appeared to be related to the severity of the clinical phenotype, as assessed by defining a severity scoring system. Our results suggest that the relative position of mutations in subrepeats will variably influence sacsin dysfunction. The characterization of the specific role of each repeated region will help in developing a comprehensive and integrated pathophysiological model of function for sacsin. PMID:23280630

Romano, Alessandro; Tessa, Alessandra; Barca, Amilcare; Fattori, Fabiana; Fulvia de Leva, Maria; Terracciano, Alessandra; Storelli, Carlo; Santorelli, Filippo Maria; Verri, Tiziano

2013-01-01

428

Warthin tumor  

Microsoft Academic Search

Objective. Warthin tumor is the second most common benign parenchymal salivary neoplasm. The purpose of this study was to evaluate the histopathologic features of Warthin tumor to determine whether a developmental pattern could be identified.Study design. Seventy-nine Warthin tumors in 63 patients (62 male and 1 female; average age, 58.62 years) were examined. All cases were histopathologically classified and morphometrically

J. M Aguirre; M. A Echebarría; R Martínez-Conde; C Rodriguez; J. J Burgos; J. M Rivera

1998-01-01

429

Malignant transformation of metachronous bilateral Schneiderian inverted papilloma of the lacrimal sac: management considerations and the contentious issue of orbital exenteration.  

PubMed

The authors present an unusual case of malignant transformation of metachronous bilateral Schneiderian inverted papilloma (IP) of the lacrimal sac. Such pathology has been sparingly covered in prior published literature, in particular with little formal discussion surrounding its optimal management. We describe the clinical presentation, course and management in a 35-year-old male with histopathological diagnosis of Squamous cell carcinoma (SCC) arising within IP. He underwent radical surgery, including orbital exenteration and medial maxillectomy. Our patient re-presented with IP in the contralateral side and subsequent malignant transformation to SCC with disseminated disease. Unfortunately he succumbed to disease approximately 20 months following initial surgery. This case raises several important questions with regard to appropriate treatment. In particular, we discuss the various management options with special consideration given to the contentious topic of orbital exenteration in such patients. We emphasise two particular controversial issues, namely, oncological efficacy of orbital preservation and the functional compromise that may result in the preserved eye. PMID:23912602

Islam, Shofiq; Eisenberg, Robert L; Hoffman, Gary R

2014-07-01

430

Les rivie?res et les sources de la Plaine du Cul-de-Sac: extrait du rapport sur les eaux souterraines de la Plaine du Cul-de-Sac  

USGS Publications Warehouse

Les principales rivières de la Plaine du Cul-de-Sac, la Rivière Grise ou Grande Rivière du Cul-de-Sac et la Rivière Blanche, prennent naissance sur le flanc Nord du Massif de la Selle à des altitudes de 1,300 à 1,800 mètres au dessus du niveau de la mer. Elles coulent à l’amont à travers des gorges profondes et sont éloignées de 9 Kms. dans la partie central de la bordure Sud de la plaine.

Taylor, George C., Jr.; Lemoine, Rémy C.

1949-01-01

431

Tricuspid valve obstruction and right heart failure due to a giant right atrial myxoma arising from the superior vena cava  

PubMed Central

Myxomas are the most common primary cardiac tumors. The cardiac myxomas are mostly diagnosed within the atria, and only a few such tumors are reported to have arisen from atrioventricular valves or pulmonary vessels. The authors here present a case of 59-year-old Chinese woman who was hospitalized for exacerbating symptoms of tricuspid stenosis and right heart failure. Echocardiography revealed a giant right atrial myxoma arising from an extremely rare site, the anterior wall of the superior vena cava. With the aid of transesophageal echocardiography, the surgical resection was performed successfully with the patient achieving complete recovery. PMID:24172033

2013-01-01

432

A Case of Adenocarcinoma of the Duodenum Arising from Brunner's Gland  

PubMed Central

We report a rare case of adenocarcinoma of the duodenum arising from Brunner's gland. A 70-year-old man with a history of hypertension was referred to us with the complaint of abdominal discomfort. Upper gastrointestinal endoscopy revealed an irregular elevated mucosa and a submucosal tumor with delle in the duodenal bulb. Biopsy specimens revealed adenocarcinoma (the former) and hyperplasia (the latter). We could not agree with the patient about performing pancreaticoduodenectomy, so under the diagnosis of primary duodenal carcinoma, we performed resection of the bulbus and the antrum. Pathological examination showed that one of the tumors was consistent with normal Brunner's glands, Brunner's gland hyperplasia and adenocarcinoma arising from Brunner's glands. The patient's postoperative course was good, but 15 months after, he developed lymph node recurrence at the site of the pancreas head. Under the diagnosis of lymph node metastasis of duodenal cancer, we performed pancreaticoduodenectomy this time. Pathological examination confirmed our preoperative diagnosis. The patient remained well after the surgery for 2 years. PMID:24403881

Kamei, Keiko; Yasuda, Takeo; Nakai, Takuya; Takeyama, Yoshifumi

2013-01-01

433

[Carcinoid tumors].  

PubMed

The authors review the most important clinical aspects of carcinoid tumors. Carcinoid tumors originating in neuroendocrine cells are rare, usually slowly-growing neoplasms, however, they may present as aggressive and rapidly progressing tumors. Epidemiologic data indicates that their prevalence is gradually increasing, which may be explained, at least in part, by the development and wider use of advanced diagnostic methods. A considerable proportion of patients with neuroendocrine tumors are symptom-free, whereas others may have carcinoid syndrome or symptoms of other endocrine syndromes. Early diagnosis may be established by the measurement of biochemical markers (serum chromogranin A, urinary 5-hydroxyindoleacetic acid) and advanced localization methods. A considerable number of patients are diagnosed at the late stages of the disease; in these cases surgical cure is not possible but surgical and/or interventional radiologic procedures which reduce tumoral mass should be still considered. The most effective drugs for symptomatic treatment of carcinoid tumors are somatostatin analogues; in addition to their beneficial effect on clinical symptoms they may stabilize tumor growth for many years and, less frequently, may produce tumor regression. The use of chemotherapeutic agents is considered in patients with aggressive, rapidly growing and advanced tumors; initial findings with temozolomide and thalidomide in clinical trials raise the possibility that these chemotherapeutic agents may prove to be new therapeutic options. Radioisotope-labeled peptide receptor therapy with 131 I-MIBG, 90 Y-DOTA-TOC or 177 Lu-DOTA-TOC may offer a highly effective option for patients with progressive and advanced stage of neuroendocrine tumors. Initial observations obtained in clinical trials with some tyrosine kinase inhibitors, antibodies against tyrosine kinases, and with inhibitors of mammalian target of rapamycin (mTOR) support the possibility that at least some of these new agents may have a role in future treatment options in patients with advanced neuroendocrine tumors. PMID:21044939

Pregun, István; Bodoky, György; Rácz, Károly; Tulassay, Zsolt

2010-11-14

434

What Is Wilms Tumor?  

MedlinePLUS

... the key statistics about Wilms tumor? What is Wilms tumor? Wilms tumor (also called Wilms’ tumor or nephroblastoma ) ... living normal, healthy lives with just one kidney. Wilms tumors Wilms tumors are the most common cancers in ...

435

Tumeur du sac vitellin du testicule au stade IIIc m?tastatique : ? propos d'un cas  

PubMed Central

Résumé Les tumeurs du sac vitellin du testicule sont rares chez l’adulte. Ces tumeurs se caractérisent par un mauvais pronostic à un stade métastatique avancé. Cependant, nous rapportons, dans le présent article, le cas clinique d’un adulte de 32 ans qui présentait une tumeur du sac vitellin du testicule au stade IIIc métastatique. Ce patient a subi une orchidectomie haute, accompagnée de quatre cycles de chimiothérapie à base de bléomycine, d’étoposide et de cisplatine. Il a répondu complètement au traitement, moyennant un recul de deux ans. PMID:25295144

Zizi, Mohamed; Ziouziou, Imad; El Yacoubi, Souhail; Khmou, Mouna; Jahid, Ahmed; Mahassini, Najat; Karmouni, Tariq; El Khader, Khalid; Koutani, Abdellatif; Andaloussi, Ahmed Iben Attya

2014-01-01

436

Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation?  

PubMed Central

Megalin and cubilin are multifunctional endocytic receptors associated with many transporting epithelia. They play an essential role in transport of nutrients through the visceral yolk sac of rodents during embryogenesis. Here, we immunolocalise them to the endodermal layer of the human yolk sac, and to the syncytiotrophoblast and cytotrophoblast cells of placental villi. In villi, the protein level of both receptors increased with gestation. The mRNA for megalin remained constant, while that encoding cubilin increased with gestation. These results suggest megalin and cubilin may be important in human maternal–fetal transfer, and that they increase across gestation to facilitate this function. PMID:23978537

Burke, K.A.; Jauniaux, E.; Burton, G.J.; Cindrova-Davies, T.

2013-01-01

437

Hypothalamic tumor  

MedlinePLUS

... at any age, but they are often more aggressive in adults than in children. In adults, tumors ... The treatment depends on how aggressive the tumor is, and whether it is a glioma or another type of cancer. Treatment may involve combinations of surgery, radiation , ...

438

Solutions Network Formulation Report. Reducing Light Pollution in U.S. Coastal Regions Using the High Sensitivity Cameras on the SAC-C and Aquarius/SAC-D Satellites  

NASA Technical Reports Server (NTRS)

Light pollution has significant adverse biological effects on humans, animals, and plants and has resulted in the loss of our ability to view the stars and planets of the universe. Over half of the U.S. population resides in coastal regions where it is no longer possible to see the stars and planets in the night sky. Forty percent of the entire U.S. population is never exposed to conditions dark enough for their eyes to convert to night vision capabilities. In coastal regions, urban lights shine far out to sea where they are augmented by the output from fishing boat, cruise ship and oil platform floodlights. The proposed candidate solution suggests using HSCs (high sensitivity cameras) onboard the SAC-C and Aquarius/SAC-D satellites to quantitatively evaluate light pollution at high spatial resolution. New products modeled after pre-existing, radiance-calibrated, global nighttime lights products would be integrated into a modified Garstang model where elevation, mountain screening, Rayleigh scattering, Mie scattering by aerosols, and atmospheric extinction along light paths and curvature of the Earth would be taken into account. Because the spatial resolution of the HSCs on SAC-C and the future Aquarius/SAC-D missions is greater than that provided by the DMSP (Defense Meteorological Satellite Program) OLS (Operational Linescan System) or VIIRS (Visible/Infrared Imager/Radiometer Suite), it may be possible to obtain more precise light intensity data for analytical DSSs and the subsequent reduction in coastal light pollution.

Andrews, Jane C.; Knowlton, Kelly

2007-01-01

439

Optimization of conditions for in situ hybridization and determination of the relative number of ribosomes in the cells of the mature embryo sac of maize  

Microsoft Academic Search

We have initiated experiments to understand the molecular regulation of embryo sac development in flowering plants by a study of ribosome synthesis and accumulation. Because of the very small size of the embryo sac and the large volume of ovule tissue it is embedded in, in situ hybridization with nucleic acid probes is presently the only practical method for such

D. A. Dow; J. P. Mascarenhas

1991-01-01

440

Solitary fibrous tumor of the intrathoracic goiter  

PubMed Central

Solitary Fibrous Tumors (SFTs) are rare primary pleural neoplasms which have recently been reported in extra-thoracic sites. In this report, solitary fibrous tumor arising in an intra-thoracic goiter with no evidence of cervical mass in a 74-year-old obese man who was found to have a large superior mediastinal mass with tracheal deviation on Chest X-Ray is presented.

Vaziri, Mohammad; Molanaei, Saadat; Tamannaei, Zeinab

2014-01-01

441

[Regeneration of transgenic Lespedeza thunbergii expressing levansucrase gene (Sac B) from Bacillus subtilis].  

PubMed

The Bacillus subtilis Sac B gene with the vacuolar targeting signal sequence driven by 35S promotor was transferred into Lespedeza thunbergii by Agrobacterium mediated method. Total 62 Kan-resistant plants were obtained, of which 5 plants were proved to be transgenic plants. The transgenic plants were characterized by PCR amplification, PCR-Southern hybridization and RT-PCR. The physiological assay results showed that the transgenic plants were more tolerant to stress than the controls under the condition of 200mmol/L NaCl and 5% PEG, respectively, and that the content of soluble sugar in trnsgenic plants was significantly higher than that of controls in the period of tests (5-15 days) under salt and PEG stress. PMID:17168316

Du, Jin-You; Chen, Xiao-Yang; Zhang, Gui-Rong; Li, Wei; Hu, Dong-Nan; Hu, Zan-Min

2006-11-01

442

Activity in the Shuttle Action Center (SAC) of the Huntsville Operations Support Center (HOSC)  

NASA Technical Reports Server (NTRS)

Launched on June 20, 1996, the STS-78 mission's primary payload was the Life and Microgravity Spacelab (LMS), which was managed by the Marshall Space Flight Center (MSFC). During the 17 day space flight, the crew conducted a diverse slate of experiments divided into a mix of life science and microgravity investigations. In a manner very similar to future International Space Station operations, LMS researchers from the United States and their European counterparts shared resources such as crew time and equipment. Five space agencies (NASA/USA, European Space Agency/Europe (ESA), French Space Agency/France, Canadian Space Agency /Canada, and Italian Space Agency/Italy) along with research scientists from 10 countries worked together on the design, development and construction of the LMS. This photo was taken in the Shuttle Action Center (SAC) of the Huntsville Operations Support Center (HOSC) Spacelab Payload Operations Control Center (SL POCC) at MSFC during the mission.

1996-01-01

443

Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac----liver transition.  

PubMed

Human embryonic development involves transition from yolk sac (YS) to liver (L) hemopoiesis. We report the identification of pluripotent, erythroid, and granulo-macrophage progenitors in YS, L, and blood from human embryos. Furthermore, comprehensive studies are presented on the number of hemopoietic progenitors and precursors, as well as of other cell types, in YS, L, and blood at precisely sequential stages in embryos and early fetuses (i.e., at 4.5-8 wk and 9-10 wk postconception, respectively). Our results provide circumstantial support to a monoclonal hypothesis for human embryonic hemopoiesis, based on migration of stem and early progenitor cells from a generation site (YS) to a colonization site (L) via circulating blood. The YS----L transition is associated with development of the differentiation program in proliferating stem cells: their erythroid progeny shows, therefore, parallel switches of multiple parameters, e.g., morphology (megaloblasts----macrocytes) and globin expression (zeta----alpha, epsilon----gamma). PMID:3722384

Migliaccio, G; Migliaccio, A R; Petti, S; Mavilio, F; Russo, G; Lazzaro, D; Testa, U; Marinucci, M; Peschle, C

1986-07-01

444

Response of the pigeon crop sac to mammotrophic hormones: Comparison between relaxin and prolactin  

SciTech Connect

The effects of relaxin (RLX), a hormone that has previously been demonstrated to have mammotrophic properties, were studied in the pigeon crop sac, a well-known target organ for mammotrophic and lactogenic hormones, and compared with the effects produced by prolactin (PRL). The two hormones were injected directly over the crop at different doses and the response was evaluated after differing times of exposure. RLX causes a dose-related increase in wet and dry weights and ({sup 3}H)thymidine and ({sup 3}H)uridine uptake by the crop mucosa, as well as morphological changes indicating growth and differentiation of the epithelial cells similar to those occurring during physiological activation in incubation and hatching. At the doses assayed, the effects of RLX were nearly identical to those obtained following PRL in the short-term experiments, but differences in functional responses were found in the long-term experiment.

Bani, G.; Sacchi, T.B.; Bigazzi, M. (Univ. of Florence (Italy))

1990-10-01

445

Small bowel perforation in a hernia sac after TVT placement at the time of colpocleisis.  

PubMed

Tension-free vaginal tape (TVT) is commonly considered as the first line of treatment for stress urinary incontinence (SUI) with demonstrated efficacy and limited complications. An 82-year-old woman with complete uterine procidentia and SUI underwent a Le Forte colpocleisis, TVT, posterior repair, and cystoscopy. A 4-cm bulge was noted over the site of the left TVT incision on postoperative day 1. On postoperative day 3, she developed bilious vomiting with slight abdominal distention. Computed tomography scan showed a strangulated left inguinal hernia. An immediate exploratory laparotomy noted an inguinal hernia displaced medially with loops of small bowel in the hernia sac. Although properly positioned, one loop of bowel was perforated by the sling mesh. A small bowel resection was performed and the mesh trimmed below the resection on involved side. At 2 months postoperative visit, the patient was asymptomatic, denied stress or urge incontinence. Vaginal examination noted well-supported vaginal walls. PMID:19641837

Gurshumov, Emil L; Klapper, Allan S; Sierecki, Ava R

2010-03-01

446

Caffeine inhibits Ca2+ uptake by subplasmalemmal calcium stores ('alveolar sacs') isolated from Paramecium cells.  

PubMed

Caffeine inhibits 45Ca2+ sequestration by subplasmalemmal calcium stores ('alveolar sacs') of low thapsigargicin sensitivity which we have isolated from the ciliated protozoan, Paramecium tetraurelia. Inhibition depends on caffeine concentration, with an IC50 of 31.8 mM. According to kinetic evaluation this is compatible with non-competitive inhibition of Ca2+ uptake, rather than with superimposed 45Ca2+ release during sequestration. It remains to be analysed whether this mechanism might be of possible relevance also for Ca2+-mediated activation in vivo in this or in any other secretory system. Such an effect could also operate indirectly, e.g., by Ca2+-release induction via sequestration inhibition. This is the first description of caffeine-mediated inhibition of Ca2+ uptake by calcium stores from a secretory system. Our data are compatible with some observations with sarcoplasmic reticulum from striated muscle fibers. PMID:8593276

Länge, S; Wissmann, J D; Plattner, H

1996-01-31

447

Rhabdomyosarcoma Arising in a Previously Irradiated Field: An Analysis of 43 Patients  

SciTech Connect

Patients with soft tissue sarcomas that arise from previously irradiated fields have traditionally been reported to have a poor prognosis. In this report, we examined the characteristics and outcomes of patients who developed a rhabdomyosarcoma in a previously irradiated field (RMS-RIF); we hypothesize that these patients should have a better outcome compared to other postradiation soft tissue sarcomas as these tumors are chemosensitive and radiosensitive. A PubMed search of the literature from 1961-2010 yielded 33 studies with data for patients with RMS-RIF. The study included 43 patients with a median age of 6.5 years at the time of radiation therapy (RT) for the initial tumor. The median RT dose was 48 Gy. The median latency period, the time from RT to development of RMS-RIF, was 8 years. The 3-year overall survival for RMS-RIF was 42%. The 3-year overall survival was 66% for patients receiving chemotherapy and local treatment (surgery and/or RT) compared to 29% for those who had systemic treatment only or local treatment only (P=.049). Other factors associated with increased 3-year overall survival included retinoblastoma initial diagnosis (P<.001), age ?18 years at diagnosis of RMS-RIF (P=.003), favorable site (P=.008), and stage 1 disease (P=.002). Age at time of RMS-RIF, retinoblastoma initial tumor, favorable site, stage 1 disease, and use of both systemic and local treatment were found to be favorable prognostic factors for 3-year overall survival.

Dang, Nguyen D. [Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas (United States)] [Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas (United States); Teh, Bin S. [Department of Radiation Oncology, The Methodist Hospital and Methodist Hospital Research Institute, Houston, Texas (United States)] [Department of Radiation Oncology, The Methodist Hospital and Methodist Hospital Research Institute, Houston, Texas (United States); Paulino, Arnold C., E-mail: apaulino@tmhs.org [Department of Radiation Oncology, The Methodist Hospital and Methodist Hospital Research Institute, Houston, Texas (United States)

2013-03-01

448

Squamous cell carcinoma arising from inverted schneiderian papilloma: a case report with oral involvement.  

PubMed

Inverted Schneiderian papilloma is an uncommon benign tumor that presents tendency to recur and propensity to be associated with malignancy in approximately 10% of the cases. Some of these lesions are isolated in the maxillary sinus, and predominantly affect white males with mean age of 50 years. We report a case of squamous cell carcinoma arising from inverted Schneiderian papilloma in the maxillary sinus extending to the mouth. The patient was submitted to extraction of a maxillary molar tooth four months before the exacerbation of the symptoms of nasal airway obstruction and facial enlargement. Computed tomography scan revealed a sinonasal mass causing opacification of the right maxillary sinus with destruction of the lateral nasal wall and maxillary sinus floor. The patient was referred to an oncology center for treatment and died from tumor progression one year after the cancer was diagnosed. The intention of this report is to alert dentists to include the inverted Schneiderian papilloma, either associated with squamous cell carcinoma, or not, in the differential diagnosis of maxillary sinus tumors with aggressive behavior, which may extend to the oral cavity or involve roots of teeth. PMID:25057422

Garcia, Alexandre Simões; Bravo-Calderón, Diego Maurício; Ferreira, Mariana Pisinato; Oliveira, Denise Tostes

2014-01-01

449

Sac-D Aquarius a Satellite for Ocean, Climate and Environment. One Year of Data  

NASA Astrophysics Data System (ADS)

The SAC-D/Aquarius satellite was launched in June 10, 2011. It's a joint mission between Argentina (through CONAE) and US (NASA). This satellite is a true Observatory with a suite of sensors for Earth Observation, its weight is 1400 kg, sun-synchronous orbit at 657 km (6 pm ascendant node), revisit of seven days. Other space agencies have contributed with instruments and support (facilities and ground segment), as CNES, CSI, ASI and AEB/INPE. The primary objective is to monitor global variations in ocean surface salinity (SSS) in order to improve the knowledge about ocean circulation, water cycle and climate. The SSS is performed with Aquarius instrument (NASA). Other oceanic and atmospheric parameters are measured with a MWR, from CONAE, in K and Ka band, as wind speed, rain rate, sea ice, water vapour and liquid water in clouds. The thermal camera (NIRST) estimates sea surface temperature and detect high temperature events (fires and volcanic eruptions). The High Sensitivity Camera (HSC) generates night images (very useful for fishery activity monitoring in the sea, studying of electrical storms, polar auroras and urban application). The DCS (Data Collection System, from CONAE) can receive meteorological and environmental data from ground platforms and distribute among users. The TDP (Technological Demonstration Package, from CONAE) measures different parameters of satellite position and velocity. Other two important instruments are ROSA (from Italy) and CARMEN 1 (from France). The first is an atmospheric sounder, it allows elaborating atmospheric profiles of temperature, pressure and humidity, and the second has detectors for studies of space debris and the effects of radiation on electronic devices. This work provides a review of the first year of data, including the status of calibration and validation, other finding and at the same time we want to present the progress in the active educational and outreach program including the information of SAC-D Aquarius Mission.

Torrusio, S.; Lagerloef, G.; Rabolli, M.; LeVine, D.

2012-07-01

450

Limb and other postcranial skeletal defects induced by amniotic sac puncture in the mouse.  

PubMed Central

A mouse model for studying the teratogenic effects of amniotic sac puncture has recently been established (MacIntyre et al. 1995), and the anomalies encountered included cleft palate, limb and tail abnormalities, and postural deformities. In order to investigate the underlying mechanism(s) involved, mouse embryos subjected to amniotic sac puncture on day 13 of gestation were examined externally on day 19, then 'cleared' and bulk stained with alizarin red S and Alcian blue to reveal, respectively, their bony and cartilaginous elements. This procedure allowed a comparison to be made between the incidence of soft tissue anomalies of the distal parts of the limbs and the appearance of the underlying skeletal elements. Despite a high incidence of soft tissue (principally digital) anomalies, relatively few skeletal anomalies were encountered. Measurements of intact long bones, and regions of ossification, were made in the major long bones of 'nonexperimental' and 'internal' controls and 'experimental' fetuses that displayed external morphological malformations to establish whether the experimental procedure had a greater effect on the proximal or distal components of the limb skeleton. No significant difference was observed when the ratios of proximal: distal length were compared with those obtained from the control series. The degree of severity of 'clubhand' and 'clubfoot' deformity was determined, and a comparison made between the severity observed on the right and left sides. This analysis revealed that for 'clubhand', the left forelimb was more severely affected than the right forelimb. The incidence of 'clubfoot' deformity was similar between the 2 sides. A possible explanation for this asymmetric effect is provided. An unexpected finding was the abnormal pattern of ossification seen in the sternum of two thirds of the 'experimental' fetuses that displayed external morphological malformations. This abnormal pattern was seen in none of the controls nor in fetuses in the 'experimental' series that displayed no external morphological malformations. Images Fig. 1 Fig. 2 Fig. 3 PMID:8771394

Chang, H H; Schwartz, Z; Kaufman, M H

1996-01-01

451

The big melt in Greenland during summer 2012 detected by MWR aboard SAC-D/Aquarius  

NASA Astrophysics Data System (ADS)

On an average summer, about half of Greenland's surface ice melts, but during the summer of 2012 about 90 percent of the ice sheet thawed at some point in mid-July, as was observed first by NASA Satellites. This kind of comprehensive surface melting is the biggest since satellites started monitoring the Arctic in 1979. However, some researchers say that it might happen about every 150 years or so in Greenland, which would make this event unusual but not unprecedented. According with climatologists, when Greenland's land-based ice sheet melts, it can have little impact on sea levels but a significant impact on weather in the Northern Hemisphere. The National Space Agency of Argentina (CONAE, Comisión Nacional de Actividades Espaciales) developed the SAC-D/Aquarius science mission (launched in June 2011), together with the National Aeronautics and Space Administration of USA (NASA). The main argentinean sensors on board the SAC-D is a MWR (Micro Wave Radiometer). This instrument is a three channel push broom microwave radiometer with 8 antenna beams per channel and two different incident angles (52° and 58°), that provides a measurement swath of approximately 380 Km. These channels provide 36.5 GHz dual horizontal and vertical polarized and 23.8 GHz horizontal polarized radiance measurements in an overlapping swath with the L-band Aquarius radiometer/scatterometer. The main objective of this instrument is to retrieve sea geophysical variables such as, columnar water vapor, wind speed, sea ice concentration and rain detection. In this work we present results obtained from MWR data for this ice melting event on Greenland, showing the capability of MWR to monitor this kind of phenomena. Brightness temperature 36.5 GHz (H-pol), June 28th Brightness temperature 36.5 GHz (H-pol), July 12th

Masuelli, S.; Labanda, M. F.; Marenchino, M.; Jacob, M. M.

2012-12-01

452

SAC-D/Aquarius MWR sea ice concentration: first results and validation  

NASA Astrophysics Data System (ADS)

The National Space Agency of Argentina (CONAE) developed the SAC-D/Aquarius science mission (launched in June 2011), together with the National Aeronautics and Space Administration (NASA). One of the sensors on board the SAC-D is a MWR (Micro Wave Radiometer). This instrument is a three channel push broom microwave radiometer with 8 antenna beams per channel and two different incident angles (52° and 58°), that provides a measurement swath of approximately 380 Km. These channels provide 36.5 GHz dual horizontal and vertical polarized and 23.8 GHz horizontal polarized radiance measurements in an overlapping swath with the L-band Aquarius radiometer/scatterometer. Geophysical variables over marine surface, such as, columnar water vapor, wind speed, sea ice concentration, and rain rate are generated with the data comming from MWR. It is well recognized that sea ice is the most significant characteristic of the polar ocean environment and influences the Earth's global climate. Some approaches such as the Bootstrap and the NASA Team algorithms have been designed to estimate sea ice concentration and type using microwave emissions. These algorithms rely primarily on the factor that polarization and spectrum are different for sea ice and open ocean. CONAE developed an algorithm with the collaboration of CFRSL (Central Florida Remote Sensing Laboratory) and SHN (Argentine Naval Hydrographic Service), for the sea ice concentration using data coming from MWR radiometer. This algorithm is based on differences between brightness temperatures corresponding to vertical and horizontal polarization of 36.5 GHz band and the gradient corresponding to values of 36.5 and 23.8 GHZ in horizontal polarization. A validation process was implemented with the collaboration of SHN researchers, using the sea ice concentration obtained from National Snow and Ice Data Center (NSIDC) for comparisons. In this work we present the first results of Sea Ice Concentration obtained using the CONAE algorithm for both, north and south poles. In addition, we show the preliminary validation analysis of those estimations.

Barreira, S.; Tauro, C. B.; Masuelli, S.; Salgado, H.; Jones, L.

2012-12-01

453

PolySac3DB: an annotated data base of 3 dimensional structures of polysaccharides  

PubMed Central

Background Polysaccharides are ubiquitously present in the living world. Their structural versatility makes them important and interesting components in numerous biological and technological processes ranging from structural stabilization to a variety of immunologically important molecular recognition events. The knowledge of polysaccharide three-dimensional (3D) structure is important in studying carbohydrate-mediated host-pathogen interactions, interactions with other bio-macromolecules, drug design and vaccine development as well as material science applications or production of bio-ethanol. Description PolySac3DB is an annotated database that contains the 3D structural information of 157 polysaccharide entries that have been collected from an extensive screening of scientific literature. They have been systematically organized using standard names in the field of carbohydrate research into 18 categories representing polysaccharide families. Structure-related information includes the saccharides making up the repeat unit(s) and their glycosidic linkages, the expanded 3D representation of the repeat unit, unit cell dimensions and space group, helix type, diffraction diagram(s) (when applicable), experimental and/or simulation methods used for structure description, link to the abstract of the publication, reference and the atomic coordinate files for visualization and download. The database is accompanied by a user-friendly graphical user interface (GUI). It features interactive displays of polysaccharide structures and customized search options for beginners and experts, respectively. The site also serves as an information portal for polysaccharide structure determination techniques. The web-interface also references external links where other carbohydrate-related resources are available. Conclusion PolySac3DB is established to maintain information on the detailed 3D structures of polysaccharides. All the data and features are available via the web-interface utilizing the search engine and can be accessed at http://polysac3db.cermav.cnrs.fr. PMID:23151233

2012-01-01

454

Effects of simulated cold fronts on the survival and behaviour of yellow perch Perca flavescens yolk-sac fry  

E-print Network

Effects of simulated cold fronts on the survival and behaviour of yellow perch Perca flavescens was to quantify survivorship of yellow perch yolk-sac fry exposed to two different temperature declines (4 and 8°C (ts = �1.33; df = 7; P = 0.22). Observations of yellow perch eggs and fry behaviour following

455

Preoperative Coil Embolization to Aortic Branched Vessels for Prevention of Aneurysmal Sac Enlargement Following EVAR: Early Clinical Result  

PubMed Central

Objective: Persistent Type 2 endoleaks (PT2) after endovascular aortic aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA) are associated with increased adverse outcomes, including aneurysmal sac enlargement and rupture. The aim of this study was to report early clinical outcomes of coil embolization (CE) to aortic branched vessels prior to EVAR and assess the effectiveness of this strategy in terms of prevention of sac growth due to PT2. Materials and Methods: Between May 2007 and April 2012, EVAR was performed for 215 cases, divided into two groups (150 cases in Group A, before introduction of CE; 21 in Group B, receiving CE before EVAR). Early clinical outcomes were compared between groups. Results: Fifty percent of cases in Group B had a marked reduction of aneurysmal sac diameter based on multi-detector row computed tomographic angiography (MDCTA) findings at the 6-month follow-up after EVAR, whereas, only 25% of cases in Group A had shrinkage of the aneurysmal sac during the same time period after EVAR. Conclusion: This strategy has the possibility of improving late outcomes of EVAR by reducing endoleak volumes beforehand. PMID:23825498

2013-01-01

456

An enhanced and automated approach for deriving a priori SAC-SMA parameters from the soil survey geographic database  

Microsoft Academic Search

This paper presents an automated approach for processing the Soil Survey Geographic (SSURGO) Database and the National Land Cover Database (NLCD), and deriving gridded a priori parameters for the National Weather Service (NWS) Sacramento Soil Moisture Accounting (SAC-SMA) model from these data sets. Our approach considerably extends methods previously used in the NWS and offers automated and geographically invariant ways

Yu Zhang; Ziya Zhang; Seann Reed; Victor Koren

2011-01-01

457

An enhanced and automated approach for deriving a priori SAC-SMA parameters from the soil survey geographic database  

NASA Astrophysics Data System (ADS)

This paper presents an automated approach for processing the Soil Survey Geographic (SSURGO) Database and the National Land Cover Database (NLCD), and deriving gridded a priori parameters for the National Weather Service (NWS) Sacramento Soil Moisture Accounting (SAC-SMA) model from these data sets. Our approach considerably extends methods previously used in the NWS and offers automated and geographically invariant ways of extracting soil information, interpreting soil texture, and spatially aggregating SAC-SMA parameters. The methodology is composed of four components. The first and second components are SSURGO and NLCD preprocessors. The third component is a parameter generator producing SAC-SMA parameters for each soil survey area on an approximately 30-m grid mesh. The last component is a postprocessor creating parameters for user-specified areas of interest on the Hydrologic Rainfall Analysis Project (HRAP) grid. Implemented in open-source software, this approach was employed by creating a set of SAC-SMA parameter and related soil property grids spanning 25 states, wherein it was shown to greatly reduce the derivation time and meanwhile yield results comparable to those based on the State Soil Geographic Database (STATSGO). The broad applicability of the methodologies and associated intermediate products to hydrologic modeling is discussed.

Zhang, Yu; Zhang, Ziya; Reed, Seann; Koren, Victor

2011-02-01

458

Normal values of the sagittal diameter of the lumbar spine (vertebral body and dural sac) in children measured by MRI  

Microsoft Academic Search

Background: The definition of normal values is a prerequisite for the reliable evaluation of abnormality in the lumbar spine, such as spinal canal stenosis or dural ectasia in patients with Marfan syndrome. Values for vertebral body diameter (VBD) and dural sac diameter (DSD) for the lumbar spine have been published in adults. In children, normal values have been established using

Walter Knirsch; Claudia Kurtz; Nicole Häffner; Mathias Langer; Deniz Kececioglu

2005-01-01

459

Respiration, nitrogen and energy metabolism of developing yolk-sac larvae of Atlantic halibut ( Hippoglossus hippoglossus L.)  

Microsoft Academic Search

The present investigation quantifies the partitioning of yolk enthalpy (C) into production of biomass (P), dissipation due to metabolism (R) and losses associated with excretion of nitrogenous end products (E) during the endogenous nutrition of developing yolk-sac larvae of Atlantic halibut (Hippoglossus hippoglossus L.). Further, the sequence of catabolic substrate oxidation and the mass-specific metabolic rate in relation to development

R. N. Finn; I. Rønnestad; H. J. Fyhn

1995-01-01

460

University of Florida Substantive Change Policy Accredited institutions with the Southern Association of Colleges and Schools (SACS)  

E-print Network

Association of Colleges and Schools (SACS) Commission on Colleges (COC) are required to notify the CommissionUniversity of Florida Substantive Change Policy Accredited institutions with the Southern of the accredited institution's programs1 1 (SACSCOC, 2013) #12;2 2. Responsibility Responsibilities of Assistant/Associate

Pilyugin, Sergei S.

461

A rare case report of appendix and cecum in the sac of left inguinal hernia (left Amyand's hernia)  

PubMed Central

This case is a rare aspect of left inguinal hernia. The patient was a 60-years old man with left scrotal mass since childhood. In the operating room, the hernia sac was opened which included cecum and appendix that is called left Amyand‘s hernia. The patient underwent herniorrhaphy with Lichtenstein repair. PMID:23483809

Anbara, Taha; Foroutankia, Raheleh

2012-01-01

462

Fate of the excluded abdominal aortic aneurysm sac: Long-term follow-up of 831 patients  

Microsoft Academic Search

Purpose: Nonresective treatment of the infrarenal abdominal aortic aneurysm by proximal and distal ligation of the aneurysm sac (exclusion) combined with aortic bypass has been previously reported. A 10-year experience with 831 patients undergoing this procedure was reviewed.Methods: From 1984 to 1994, 831 (761 elective, 70 urgent) of 1103 patients being treated for abdominal aortic aneurysm underwent repair with the

Michael Resnikoff; R. Clement Darling; Benjamin B. Chang; William E. Lloyd; Philip S. K. Paty; Robert P. Leather; Dhiraj M. Shah

1996-01-01

463

The effect of the renin--angiotensin system on mucosal water and sodium transfer in everted sacs of rat jejunum  

PubMed Central

1. Mucosal water and sodium transfer were measured in everted sacs of rat jejunum. 2. Rats maintained on a high sodium diet did not show consistently reduced mucosal water transfer and aldosterone also failed to stimulate transfer unless the control untreated values were low. 3. Adrenalectomy produced little reduction in mucosal water transfer and aldosterone was without effect on water transfer in sacs from adrenalectomized rats. 4. Vasopressin had no effect on mucosal transfer. 5. Levels of water transfer were not reduced after hypophysectomy nor did aldosterone injection increase transfer. 6. Mucosal water transfer in sacs from adrenalectomized—nephrectomized rats was low and was significantly increased by aldosterone injection or by injection of crude kidney extract. 7. A significant increased mucosal water and sodium transfer was observed when sacs from adrenalectomized—nephrectomized rats were incubated with angiotensin at a concentration of 10-10g/ml. 8. It is suggested that the renin—angiotensin system may be involved in the maintenance of sodium homoeostasis by a direct action on sodium transporting mechanisms. PMID:4322443

Crocker, Ann D.; Munday, Kenneth A.

1970-01-01

464

MELER et al.: BETASAC: A NEW CONDITIONAL SAMPLING FOR RANSAC 1 BetaSAC: A New Conditional Sampling For  

E-print Network

named BetaSAC, in reference to the beta distribution. Our proposed sampler builds a hypothesis set. It is essentially composed of two steps that are repeated iteratively. · Hypothesize. A sample of size m among the N sufficient cardinality to determine the model parameters. · Test. The hypothesis is verified against the rest

Boyer, Edmond

465

Singing with reduced air sac volume causes uniform decrease in airflow and sound amplitude in the zebra finch.  

PubMed

Song of the zebra finch (Taeniopygia guttata) is a complex temporal sequence generated by a drastic change to the regular oscillations of the normal respiratory pattern. It is not known how respiratory functions, such as supply of air volume and gas exchange, are controlled during song. To understand the integration between respiration and song, we manipulated respiration during song by injecting inert dental medium into the air sacs. Increased respiratory rate after injections indicates that the reduction of air affected quiet respiration and that birds compensated for the reduced air volume. During song, air sac pressure, tracheal airflow and sound amplitude decreased substantially with each injection. This decrease was consistently present during each expiratory pulse of the song motif irrespective of the air volume used. Few changes to the temporal pattern of song were noted, such as the increased duration of a minibreath in one bird and the decrease in duration of a long syllable in another bird. Despite the drastic reduction in air sac pressure, airflow and sound amplitude, no increase in abdominal muscle activity was seen. This suggests that during song, birds do not compensate for the reduced physiological or acoustic parameters. Neither somatosensory nor auditory feedback mechanisms appear to effect a correction in expiratory effort to compensate for reduced air sac pressure and sound amplitude. PMID:18083734

Plummer, Emily Megan; Goller, Franz

2008-01-01

466

Molecular dynamics simulations of the hyperthermophilic protein sac7d from Sulfolobus acidocaldarius: contribution of salt bridges to thermostability1  

Microsoft Academic Search

Hyperthermophilic proteins often possess an increased number of surface salt bridges compared with their mesophilic homologues. However, salt bridges are generally thought to be of minor importance in protein stability at room temperature. In an effort to understand why this may no longer be true at elevated temperatures, we performed molecular dynamics simulations of the hyperthermophilic protein Sac7d at 300

Paul I. W. de Bakker; Philippe H. Hunenberger; J. Andrew McCammon

1999-01-01

467

Conditional suicide system of Escherichia coli released into soil that uses the Bacillus subtilis sacB gene.  

PubMed

The sacB gene from Bacillus subtilis confers sucrose sensitivity upon gram-negative bacteria. The gene was investigated for use as a potential conditional suicide system for Escherichia coli released into soil. To ensure against the loss of the cell death function encoded under nonselective conditions, the nptI-sacR-B suicide cassette was inserted into the E. coli chromosome by using a circular nonreplicative integration vector. Stability studies yielded no loss of the suicide cassette in the integrated E. coli EL1026 strain. sacB induction in the absence of a selective pressure resulted in a lysis efficiency of up to 99.9%. The microcosm experiments confirmed the ability of the suicide cassette to limit the growth and reduce the survival of E. coli strains released into soil. Sucrose addition to sterile soil resulted in a 10(-3)-fold reduction of the final E. coli population density. sacB induction prevented the proliferation and triggered the rapid disappearance of E. coli from natural soil. Mutation to sucrose tolerance occurred at a frequency of 10(-5), making E. coli EL1026 a potential counterselectable donor strain for gene transfer studies. Specificity and potential adaptability to a wide range of gram-negative bacteria are additional conveniences of this conditional suicide system for the containment and counterselection of engineered microorganisms. PMID:8517732

Recorbet, G; Robert, C; Givaudan, A; Kudla, B; Normand, P; Faurie, G

1993-05-01

468

A Demonstration of the System Assessment Capability (SAC) Rev. 1 Software for the Hanford Remediation Assessment Project  

SciTech Connect

The System Assessment Capability (SAC) is a suite of interrelated computer codes that provides the capability to conduct large-scale environmental assessments on the Hanford Site. Developed by Pacific Northwest National Laboratory for the Department of Energy, SAC models the fate and transport of radioactive and chemical contaminants, starting with the inventory of those contaminants in waste sites, simulating transport through the environment, and continuing on through impacts to the environment and humans. Separate modules in the SAC address inventory, release from waste forms, water flow and mass transport in the vadose zone, water flow and mass transport in the groundwater, water flow and mass transport in the Columbia River, air transport, and human and ecological impacts. The SAC supports deterministic analyses as well as stochastic analyses using a Monte Carlo approach, enabling SAC users to examine the effect of uncertainties in a number of key parameters. The initial assessment performed with the SAC software identified a number of areas where both the software and the analysis approach could be improved. Since that time the following six major software upgrades have been made: (1) An air pathway model was added to support all-pathway analyses. (2) Models for releases from glass waste forms, buried graphite reactor cores, and buried naval reactor compartments were added. (3) An air-water dual-phase model was added to more accurately track the movement of volatile contaminants in the vadose zone. (4) The ability to run analyses was extended from 1,000 years to 10,000 years or longer after site closure. (5) The vadose zone flow and transport model was upgraded to support two-dimensional or three-dimensional analyses. (6) The ecological model and human risk models were upgraded so the concentrations of contaminants in food products consumed by humans are produced by the ecological model. This report documents the functions in the SAC software and provides a number of example applications for Hanford problems. References to theory documents and user guides are provided as well as links to a number of published data sets that support running analyses of interest to Hanford cleanup efforts.

Eslinger, Paul W.; Kincaid, Charles T.; Nichols, William E.; Wurstner, Signe K.

2006-11-06

469

Wilms' Tumor  

MedlinePLUS

... Doctors usually diagnose and remove the tumor in surgery. Other treatments include chemotherapy and radiation and biologic therapies. Biologic therapy boosts your body's own ability to fight cancer. NIH: National Cancer Institute

470

Pregnancy Tumor  

MedlinePLUS

... Pregnancy tumors are not dangerous. Causes include: Poor oral hygiene (not enough brushing, flossing or cleanings to remove food or plaque) Irritation of the area (caused by the mouth's inflammatory response to the food or plaque) Trauma ...