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1

Primary Yolk Sac Tumor Arising in the Pancreas with Hepatic Metastasis: a Case Report  

PubMed Central

Extragonadal yolk sac tumor (YST) is a relatively rare entity. We describe here the case of an extragonadal YST that occurred in the pancreas with hepatic metastasis in an adult woman. The contrast enhanced CT images of the abdomen revealed a heterogeneous, solitary mass occupying the pancreatic neck and body with slightly inhomogeneous contrast enhancement. Two low-density lesions in the liver were also displayed on the CT images. The patient underwent surgery and the diagnosis of YST was pathologically verified.

Zhang, Bo; Gao, Shunliang; Chen, Ying

2010-01-01

2

Primary yolk sac tumor arising in the pancreas with hepatic metastasis: a case report.  

PubMed

Extragonadal yolk sac tumor (YST) is a relatively rare entity. We describe here the case of an extragonadal YST that occurred in the pancreas with hepatic metastasis in an adult woman. The contrast enhanced CT images of the abdomen revealed a heterogeneous, solitary mass occupying the pancreatic neck and body with slightly inhomogeneous contrast enhancement. Two low-density lesions in the liver were also displayed on the CT images. The patient underwent surgery and the diagnosis of YST was pathologically verified. PMID:20592932

Zhang, Bo; Gao, Shunliang; Chen, Ying; Wu, Yulian

2010-01-01

3

Ovarian yolk sac tumors in older women arising from epithelial ovarian tumors or with no detectable epithelial component.  

PubMed

Yolk sac tumor (YST) occurs rarely in older women, either in association with a variety of ovarian epithelial tumors or, considerably less often, without an identifiable epithelial precursor. The patients often have elevated serum levels of ?-fetoprotein that roughly correlate with the amount of the YST component. In postmenopausal women with an ovarian mass and elevated serum levels of ?-fetoprotein, a tumor of this type should be suspected. Endometrioid carcinoma is the most common putative precursor, and the tumor is often associated with an endometriotic cyst; however, malignant Müllerian mixed tumor and mucinous neoplasms have also been reported as precursors. We report 4 cases of YST in postmenopausal women. Of the 3 cases with an identified epithelial component, 1 was serous carcinoma, another was clear cell adenocarcinoma, and the third was an admixture of endometrioid and clear cell adenocarcinoma arising from an endometriotic cyst. Although a precursor epithelial ovarian neoplasm, typically a malignancy (somatic carcinoma), is usually identified, no precursor neoplasm was observed in 1 of our cases and in 5 cases from the literature. We believe that YSTs in older women, whether or not an epithelial component is detected histologically, constitute a single entity that is distinct from YSTs in younger patients and should be treated aggressively. Neoplasms with a YST component in older women are less responsive to the chemotherapy currently used for ovarian germ cell tumors; therefore, adjuvant therapy should include platinum-based chemotherapy designed to treat both epithelial ovarian cancer and germ cell tumors. Of the 24 reported cases, including our own, 17 died of neoplasms within 25 months and another was living with disease at 2 months. However, 2 more recent patients treated aggressively with platinum-based chemotherapy designed to treat both epithelial and germ cell tumor components with stage 1 disease are living and have been disease free >1 year after operation. PMID:21804392

Roth, Lawrence M; Talerman, Aleksander; Levy, Tally; Sukmanov, Oleg; Czernobilsky, Bernard

2011-09-01

4

Yolk sac tumor in the nasal cavity.  

PubMed

Yolk sac carcinoma (YST) is rare malignant tumor of germ cell origin. It most commonly arises from the gonads but extragonadal sites of origin are reported in 20% of the cases. Head and neck germ cell tumors are uncommon and only a small number are malignant. We present the case of a 48 years old man presenting with a YST of the sinonasal tract and the arterior skull base. The patient underwent an anterior craniofacial resection and postoperative radiotherapy and continues showing no evidence of disease seven years after treatment. We discuss radiological and histological features of this tumor and provide a review of three other cases of YST arising in children. PMID:18598836

Filho, Bernardo Cunha Araujo; McHugh, Jonathan B; Carrau, Ricardo L; Kassam, Amin B

2008-01-01

5

Krukenberg tumor with yolk sac tumor differentiation.  

PubMed

An unusual case of bilateral Krukenberg tumor with foci of yolk sac tumor (YST) differentiation occurring in a 50-year-old patient is reported. The primary tumor was in the gastric antrum, and it showed morphology of poorly differentiated adenocarcinoma with diffuse and solid growth pattern. A component of typical YST was not found in the gastric primary and lymph node metastases, although some cells in these locations were positive for alpha-fetoprotein. In the ovarian metastases, YST element showed microcystic/reticular and solid patterns, whereas the adenocarcinoma component was of diffuse type with signet ring cells and with some undifferentiated areas. The case represents further example of the somatic cell-derived tumor with focal germ cell-type differentiation and the first report of YST differentiation in Krukenberg tumor. PMID:18317220

Zamecnik, Michal; Voltr, Lubomir; Stuk, Jan; Chlumska, Alena

2008-04-01

6

Gastric adenocarcinoma with yolk sac tumor differentiation and liver metastasis of yolk sac tumor component.  

PubMed

Gastric adenocarcinoma with yolk sac tumor (YST) differentiation has rarely been reported. We report a case of primary gastric adenocarcinoma with yolk sac tumor differentiation and liver metastases of the YST component in a 50-years-old patient. This was suspected due to high serum level of alpha fetoprotein in the presence of a gastric fundal tumor. Gastric carcinoma with yolk sac tumor component is a rare entity with a poor prognostic outcome. PMID:24294529

Bihari, Chhagan; Rastogi, Archana; Chandan, K N; Yadav, Vikas; Panda, Dipanjan

2013-01-01

7

Gastric Adenocarcinoma with Yolk Sac Tumor Differentiation and Liver Metastasis of Yolk Sac Tumor Component  

PubMed Central

Gastric adenocarcinoma with yolk sac tumor (YST) differentiation has rarely been reported. We report a case of primary gastric adenocarcinoma with yolk sac tumor differentiation and liver metastases of the YST component in a 50-years-old patient. This was suspected due to high serum level of alpha fetoprotein in the presence of a gastric fundal tumor. Gastric carcinoma with yolk sac tumor component is a rare entity with a poor prognostic outcome.

Bihari, Chhagan; Rastogi, Archana; Chandan, K. N.; Yadav, Vikas; Panda, Dipanjan

2013-01-01

8

Primary yolk sac tumor of the cerebellar vermis: A case report.  

PubMed

Extragonadal germ cell tumors are rare and comprise 2-5% of all germ cell tumors. Seminoma/dysgerminoma, teratoma, yolk sac tumor (YST) and mixed germ cell tumors are few of the extragonadal germ cell tumors arising within the brain. Of these, primary pure YSTs arising in the brain are extremely rare and arise in the pineal (62%) and suprasellar (31%) regions. Primary YST occurring in the cerebellum is exceedingly rare, associated with a very poor prognosis and has been reported in less than 10 cases in literature. We herein report a case of primary pure yolk sac tumor in the cerebellar vermis in a 2-year-old child. PMID:24943765

Shenoy, Asha S; Desai, Heena M; Tyagi, Devendra K; Savant, Hemant V; Kavishwar, Vikas S; Balasubramaniam, Meenakshi

2014-01-01

9

Primary yolk sac tumor of the common bile duct.  

PubMed

Yolk sac tumor (YST) is a germ cell neoplasm usually arising from the gonads. Extragonadal YST has been reported in the mediastinum, retroperitoneum, liver, and pelvis. Primary YST of the common bile duct (CBD) has not been previously reported. We describe an 11-month-old girl with a YST arising from the CBD who presented with obstructive jaundice. Imaging studies revealed an intraluminal CBD mass with intrahepatic biliary dilatation and extraluminal infiltration of the head of the pancreas. A complete resection was carried out, and postoperative chemotherapy with cisplatin, etoposide and bleomycin was administered. PMID:21683236

Munghate, Gayatri S; Agarwala, Sandeep; Bhatnagar, Veereshwar

2011-06-01

10

Sacrococcygeal Yolk Sac Tumor: An Uncommon Site  

PubMed Central

A 30-month-old male infant presented with sacrococcygeal and pre-sacral mass. Ultrasound (US) abdomen revealed a huge pre-sacral mass with irregular margins extending into the pelvis, pushing the rectum antero-laterally. CT scan and MRI confirmed the US findings. Serum alpha fetoprotein level was abnormally elevated. Histopathological examination of surgical-specimen suggested sacrococcygeal yolk sac tumor (YST).

Koubaa-Mahjoub, Wafa; Jouini, Raja; Bel Haj Salah, Meriem; Kaabar, Nejib; Chadli-Debbiche, Achraf

2012-01-01

11

Sacrococcygeal yolk sac tumor: an uncommon site.  

PubMed

A 30-month-old male infant presented with sacrococcygeal and pre-sacral mass. Ultrasound (US) abdomen revealed a huge pre-sacral mass with irregular margins extending into the pelvis, pushing the rectum antero-laterally. CT scan and MRI confirmed the US findings. Serum alpha fetoprotein level was abnormally elevated. Histopathological examination of surgical-specimen suggested sacrococcygeal yolk sac tumor (YST). PMID:23061033

Khanchel-Lakhoua, Fatma; Koubâa-Mahjoub, Wafa; Jouini, Raja; Bel Haj Salah, Meriem; Kaabar, Néjib; Chadli-Debbiche, Achraf

2012-09-01

12

Primary yolk sac tumor of seminal vesicle: a case report and literature review  

PubMed Central

Background Yolk sac tumor (endodermal sinus tumor) is a rare malignant germ cell tumor arising in the testis or ovary. Extragonadal yolk sac tumor is even rarer and has only been described in case reports. Due to the rarity of the tumors, the appropriately optimal treatment remains unclear. We report a case of yolk sac tumor in the seminal vesicle. Case A 38-year-old Asian male presented with gross hematuria and hemospermia. Transrectal ultrasound scan showed a solid mass in the left seminal vesicle and the scrotal sonography showed no abnormalities. Bilateral seminal vesicles were resected, and histopathological examination showed a typical pattern of yolk sac tumor (YST). The patient responded poorly to comprehensive treatment of radiotherapy, chemotherapy and surgeries, developed systemic multiple metastases, and died of cachexia one and half years after diagnosis.

2012-01-01

13

Primary pure gastric yolk sac tumor.  

PubMed

We describe here a case of pure gastric yolk sac tumor (YST). A 62-year-old patient underwent gastrectomy with D2 dissection. The histological report confirmed the diagnosis of YST and that two of the 14 regional lymph nodes removed were metastatic. Three courses of PEB regimen chemotherapy were delivered subsequently. Three months later the patient experienced dysphagia from stenosis of the anastomosis and a computerized tomography scan showed tumor recurrence with peritoneal nodules; the patient died one year after surgery. The origin of gastric YST is unclear but involvement of migrating germ cells during embryonic development or multipotential neoplastic protoepithelial cells of the gastric mucosa have been suggested. Generally the prognosis of gastric YST is poor and the standard therapeutic approach beyond surgery is still uncertain. PMID:21139939

Magni, Elena; Sonzogni, Angelica; Zampino, Maria Giulia

2010-01-01

14

Papillary endolymphatic sac tumor: a case report.  

PubMed

Glandular tumors involving the middle ear are rare and distinguishing between adenoma and adenocarcinoma remains difficult. A distinct subclass of these tumors demonstrates microscopic papillary architecture and has a propensity to erode the petrous bone and extend intracranially. The term "aggressive papillary middle ear tumor" has recently been proposed to describe this more invasive type of middle ear tumor. These tumors cause symptoms even when microscopic in size. Although histologically benign, they have been locally destructive with frequent intracranial extension and patients may die of uncontrolled local disease. These tumors do not metastasize but there is single case report of drop metastasis to the spine in the literature. Hence this tumor must be distinguished from other benign tumors of the middle ear. These rare neoplasms constitute a distinct pathological entity and deserve wider recognition. PMID:22953101

Arava, S; Soumya, R M; Chitragar, S; Safaya, R; Chandrashekhar, S H; Thakar, Alok

2012-01-01

15

Papillary Endolymphatic Sac Tumor: A Case Report  

PubMed Central

Glandular tumors involving the middle ear are rare and distinguishing between adenoma and adenocarcinoma remains difficult. A distinct subclass of these tumors demonstrates microscopic papillary architecture and has a propensity to erode the petrous bone and extend intracranially. The term “aggressive papillary middle ear tumor” has recently been proposed to describe this more invasive type of middle ear tumor. These tumors cause symptoms even when microscopic in size. Although histologically benign, they have been locally destructive with frequent intracranial extension and patients may die of uncontrolled local disease. These tumors do not metastasize but there is single case report of drop metastasis to the spine in the literature. Hence this tumor must be distinguished from other benign tumors of the middle ear. These rare neoplasms constitute a distinct pathological entity and deserve wider recognition.

Arava, S.; Soumya, R. M.; Chitragar, S.; Safaya, R.; Chandrashekhar, S. H.; Thakar, Alok

2012-01-01

16

Identification and characterization of cancer stem cells in ovarian yolk sac tumors.  

PubMed

Recent evidence supports the cancer stem cell theory, that is, that malignant tumors arise from cells termed cancer stem cells or tumor-initiating cells that have the ability to self-renew and are responsible for maintaining the tumor. Cells with marked tumor-initiating capacity have recently been identified in a number of solid tumors. CD133 (PROM1, human prominin-1) has been used as a marker to detect stem cells (progenitor cells) and cancer stem cells (tumor-initiating cells) in various tissues. Ovarian yolk sac tumors (YSTs) are rare and highly malignant. The present study was designed to evaluate the tumor-forming ability of CD133(+) cells in ovarian YST cell lines and to examine the characteristics of CD133(+) cells, such as cell growth and invasiveness. Our data suggest ovarian YST to be maintained by a rare fraction of cancer stem-like cells that express the cell surface marker CD133. PMID:20804503

Suzuki, Shiro; Terauchi, Mikio; Umezu, Tomokazu; Kajiyama, Hiroaki; Shibata, Kiyosumi; Nawa, Akihiro; Kikkawa, Fumitaka

2010-10-01

17

Metastasis of testicular yolk sac tumor to cauda equina.  

PubMed

Primary germ cell tumors may spread to the lung, liver, brain, and bone hematogenously. However, spinal metastasis is extremely rare. A case with yolk sac tumor (YST) and cauda equina metastasis was presented in a 2-year-old boy. Two months prior to admisssion, he underwent left radical orchiectomy for testicular YST. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed spinal and cauda equina involvement. This is the first report of metastasis of testicular YST to cauda equina in a child. PMID:21355679

Unal, Ozkan; Beyazal, Mehmet; Avcu, Serhat; Akbayram, Sinan; Akgun, Cihangir

2011-01-01

18

Primary yolk sac tumor of bilateral basal ganglia.  

PubMed

A primary intracranial yolk sac tumor (YST) is a type of germ cell tumor (GCT) and usually involves the pineal or suprasellar regions, as do other GCTs. Primary YST in the basal ganglia is not common, and bilateral basal ganglia involvement is even rarer. Early diagnosis is often difficult because of minimal or subtle findings without space-occupying lesions shown on neuroimaging during the early course of the disease. We report a case of primary intracranial YST encountered in the basal ganglia bilaterally and describe the clinical presentation, diagnostic problem, imaging characteristics, histopathologic features, and prognosis of the tumor. To the best of our knowledge, this is only the third reported case of primary YST confined to the basal ganglia in the literature. PMID:20728859

Wang, Chung-Hao; Hsu, Ting-Rong; Yang, Tzu-Ying; Wong, Tai-Tong; Chang, Feng-Chi; Ho, Donald Ming-Tak; Chiang, Kuo-Liang; Chang, Kai-Ping

2010-08-01

19

Wilms' tumor arising in a horseshoe kidney  

Microsoft Academic Search

The incidence of horseshoe kidney (HK) is estimated at 1 in 400 cases. The occurrence of Wilms' tumor (WT) in a HK is an\\u000a uncommon event, estimated at 0.4%–0.9% of all WTs. We report a case of WT arising from the isthmus of a HK and review the\\u000a literature on the subject.

M. C. Talpallikar; V. Sawant; S. Hirugade; S. S. Borwankar; H. Sanghani

2001-01-01

20

Wilms' tumor arising in a horseshoe kidney.  

PubMed

The incidence of horseshoe kidney (HK) is estimated at 1 in 400 cases. The occurrence of Wilms' tumor (WT) in a HK is an uncommon event, estimated at 0.4%-0.9% of all WTs. We report a case of WT arising from the isthmus of a HK and review the literature on the subject. PMID:11527192

Talpallikar, M C; Sawant, V; Hirugade, S; Borwankar, S S; Sanghani, H

2001-07-01

21

Sporadic endolymphatic sac tumor - a diagnostic and therapeutic challenge  

PubMed Central

Endolymphatic sac tumor (ELST) is a rare low-grade locally aggressive neoplasm of the inner ear that may occur sporadically or in the setting of von Hippel-Lindau syndrome. We herein present a case of sporadic ELST in a 39-year-old man, treated using an interdisciplinary approach (surgery + radiotherapy), with a 10-year follow-up. The patient presented with hearing loss of sudden onset. The treatment of choice for ELST is radical tumor resection, which is associated with a good long-term prognosis. Remission may last for years, but there may be local recurrences, probably as a result of incomplete resection. Adjuvant radiotherapy is an option in case of recurrence and could be discussed after incomplete resection. The purpose of this report is to call attention to ELSTs, which are difficult to diagnose due to their rarity and variety of presentations.

Kunzel, Julian; Agaimy, Abbas; Hornung, Joachim; Lell, Michael; Ganslandt, Oliver; Semrau, Sabine; Zenk, Johannes

2014-01-01

22

Cardiac metastasis from yolk sac tumor: case report and review  

PubMed Central

Cardiac metastasis of germ cell tumors is extremely rare, particularly in females. We report a case of a 26-year-old previously healthy woman who presented with a 5-month history of abdominal pain, weight loss, fever, generalized lymphadenopathy, and acanthosis nigricans. Biopsy of cervical lymph nodes revealed a poorly differentiated neoplasm. Immunohistochemical staining was positive for alpha-fetoprotein suggesting the diagnosis of a germ cell tumor. During the investigation, the patient developed heart failure and a mass attached to the right ventricle was detected by the echocardiogram. In a few days, she developed multiple organ failure and died. Post-mortem examination revealed a malignant mixed germ cell tumor of the right ovary with extensive hematogenic and lymphatic dissemination, a polypoid mass attached to the right ventricle, emboli in the endocardial and epicardial vessels, and infiltration surrounding the coronary arteries. To the best of our knowledge this is the third report of grossly visible heart metastases from a yolk sac tumor in a female patient. A summary of all published cases of germ cell tumors with cardiac metastasis over the last 20 years is also presented.

2013-01-01

23

Endolymphatic sac tumor: case report and review of the literature  

PubMed Central

Endolymphatic sac tumor (ELST) is a rare neoplasm which can be encountered sporadically or in Von Hippel-Lindau (VHL) disease. Here we report a sporadic case of ELST in 31-year-old man. Neither the symptoms nor a family history of VHL disease were found in the patient. CT imaging demonstrated an expansile lytic lesion of the mastoid process of the left petrous bone. MR scanning revealed a 5.2 cm × 4.7 cm × 4.2 cm mass which showed hyperintensity on T1- and T2-weighted images. Histologic sections showed a papillary, cystic or glandular architecture. The papillary and glandular structures were lined by a single layer of flattened cuboidal-to-columnar cells. The stroma of the papillary fronds was richly vascularized and chronically inflamed. The tumor showed diffusely positive reactivity with cytokeratin (Pan), cytokeratin 19, cytokeratin 5/6, cytokeratin 7, EMA, vimentin, CD56, and NSE and also showed variable reactivity with glial fibrillary acidic protein (GFAP) and VEGF. The Ki-67 immunostain showed a proliferation index of < 1%. Because the mass was large, it was difficult to extirpate surgically. After surgery, the patient underwent gamma-knife radiosurgery for residual tumor. The findings indicate that ELST is a rare neoplasm with benign histopathological appearance and clinically destructive behavior. Because of the rarity of this tumor, it can easily be confused with other tumors such as paraganglioma, middle ear adenoma, adenocarcinoma, papillary carcinoma of thyroid or choroid plexus papilloma. Owing to its locally aggressive nature, it is difficult to extirpate surgically when it is large. Virtual Slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7973320646763012

2012-01-01

24

Endolymphatic sac tumor with von Hippel-Lindau disease: report of a case with atypical pathology of endolymphatic sac tumor  

PubMed Central

The authors described a case of a patient with co-existing endolymphatic sac tumor (ELST) and hemangioblastoma in the posterior cranial fossa, which belonged to a subtype of Von Hippel-Lindau (VHL) disease confirmed by the test of VHL-gene. The signs in this 42-year-old female included intermittent headache and dizziness. Imaging revealed a giant mass in the right cerebellopontine angle (CPA) region and another lesion in the left cerebellar hemisphere. The results of biopsy after two operations confirmed the diagnosis respectively. Both of the tumors were resected totally. Nevertheless, we had to confess the misdiagnosis as vascular tumor instead of ELST at the initial diagnosis because of the rarity of ELST associated with atypical histological characteristics. The purposes we reported this case were to describe the atypical pathological feature of ELST and the mutation of germline VHL not mentioned in previously literature, furthermore, to foster understanding of ELSTs with the avoidance of the similar misdiagnosis as far as possible in future.

Yang, Xiang; Liu, Xue-Song; Fang, Yuan; Zhang, Xiu-Hui; Zhang, Yue-Kang

2014-01-01

25

Sinonasal pure yolk sac tumor: a case report and literature review.  

PubMed

Extragonadal pure yolk sac tumor of sinonasal origin is very rare. We report herein a case with sinonasal yolk sac tumor in a 1 year and 3 months old girl. The initial complaint was persistent nasal bleeding for about 2 months. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a lobulated soft tissue mass in paranasal sinus that extended to oral cavity, nasopharynx, and oropharynx. The histology showed typical features of yolk sac tumor and the positive immunohistochemical staining of SALL4 and ?-fetoprotein. After tumor excision, adjuvant chemotherapy of JEB regimen was prescribed. After the follow-up for 13-months, ?-fetoprotein was normal and neither tumor progression nor metastasis was found. We review the previous literature and discuss the etiology, histology, treatment, and the prognosis of the rare sinonasal yolk sac tumor. PMID:24547992

Chuang, Huei Chieh; Kang, Chung-Jan; Lee, Li-Yu

2014-06-01

26

MR Imaging Findings of Extraovarian Endocervical Mucinous Borderline Tumors Arising from Pelvic Endometriosis  

PubMed Central

We report MR imaging findings of a rare case of endocervical mucinous borderline tumor (MBT) involving the cul-de-sac and left fallopian tube arising from extensive pelvic endometriosis with pathologic correlation in a 35-year-old woman presented with vague pelvic pain. Endocervical MBT is a type of endometriosis-associated carcinoma. Imaging findings of endocervical MBT are unilocular or oligolocular cystic lesions with enhancing mural nodules, which are different from those of the more common intestinal type MBT.

Yeo, Dong Myung; Byun, Jae Young; Lee, Ahwon; Kim, Mee-Ran

2013-01-01

27

A subcutaneous paraspinal yolk sac tumor in a child.  

PubMed

A 3-year-old girl underwent a surgery at an external center on July 2011 for a swelling in the left lumbar paravertebral subcutaneous region. The mass was completely excised and the pathologic diagnosis was a yolk sac tumor (YST). Laboratory tests revealed a serum ?-fetoprotein level of 278 IU/mL. Investigations using bone scintigraphy and magnetic resonance imaging revealed a scar tissue at the surgical site and lesions indicating metastasis at the lumbar first, second, third, and fifth vertebra. The patient was administered 5 cycles of PEB (cisplatin, etoposide, bleomycin) treatment. The serum ?-fetoprotein was 3 IU/mL after the treatment. The lumbar magnetic resonance imaging and bone scintigraphy results were normal. The patient continues to be in remission since June 2012. YSTs are most commonly seen in the testis, ovary, and sacrococcygeal regions. Atypical locations have been reported with the primary lesion in the stomach, diaphragm, omentum, sino-nasal region, cranial base, lungs, vagina, and penis. Our case is probably a YST with an atypical location derived from preliminary cells left under the skin because of a migration defect. PMID:24556799

Tekgündüz, Sibel A; Bozkurt, Ceyhun; Sahin, Gürses; Apaydin, Sema; Ören, Ay?e C; Balkaya, Eda; Ertem, Ay?e U

2014-03-01

28

[The problems of yolk sac tumor morphogenesis in a light of the tumor stem cell theory].  

PubMed

The analysis of possible morphogenesis of the different structures in human yolk sac tumor has been considered. The author has supposed that features of blood vessel microarchitecture formation and perpetual differentiation of tumor cells or theirs functional modification play a crucial role in the morphogenesis of YST. The immunohistochemical investigation of some stem cells markers has showed the necessity of accounting of their distribution pattern in various cellular structures for the differential diagnosis of morphogenetical steps of YST. The growth of tumor cells differentiation rate correlates with increasing of stem cells markers expression as well c-kit > OCT4 > CD30 > PLAP. PMID:22164428

Karseladze, A I

2011-01-01

29

Laparoscopic treatment of a Yolk Sac Tumor: case report and literature review  

PubMed Central

SUMMARY We report the case of a yolk sac tumor of the ovary in a 26 years old woman. The laparoscopic approach and the BEP chemotherapy were fundamental to have a minimally invasive treatment and to preserve fertility.

Guida, Maurizio; Pignata, Sandro; Palumbo, Anna Rita; Miele, Gianmarco; Marra, Maria Luisa; Visconti, Federica; Zullo, Fulvio

30

Primary yolk sac tumor of the omentum: a case report and literature review.  

PubMed

Yolk sac tumor (YST) is a rare malignant tumor originating from germ cells. YST normally originates from the gonads, rarely occurring in extragonadal sites. We report a 35-year-old man with YST arising in the omentum, which is the first reported case of a primary YST of the omentum in an adult male. The patient presented to the community hospital with abdominal distension. A CT scan showed thickening of the omentum with ascites. The patient underwent open biopsy of the omental mass. The Pathology Department of the hospital could not make a definitive diagnosis at that time, and the tumor was considered a cancer of unknown primary (CUP) origin with features of primary colorectal cancer based on the immunohistochemistry (IHC) findings of the biopsy specimen (CK7-/CK20+ and CDX-2+). He was then referred to our hospital. We found that serum ?-fetoprotein was abnormally elevated to 7,144 ng/ml (normal <10.0), and reevaluation of the biopsy specimen revealed microcystic or reticular patterns of tumor cells with Schiller-Duval bodies typical of YST. The present case suggests that IHC is a very useful diagnostic tool for subtyping CUP but should be interpreted in the context of clinical and morphological findings. PMID:23341810

Harano, Kenichi; Ando, Masashi; Sasajima, Yuko; Yunokawa, Mayu; Yonemori, Kan; Shimizu, Chikako; Tamura, Kenji; Katsumata, Noriyuki; Tsuda, Hitoshi; Fujiwara, Yasuhiro

2012-09-01

31

Primary Yolk Sac Tumor of the Omentum: A Case Report and Literature Review  

PubMed Central

Yolk sac tumor (YST) is a rare malignant tumor originating from germ cells. YST normally originates from the gonads, rarely occurring in extragonadal sites. We report a 35-year-old man with YST arising in the omentum, which is the first reported case of a primary YST of the omentum in an adult male. The patient presented to the community hospital with abdominal distension. A CT scan showed thickening of the omentum with ascites. The patient underwent open biopsy of the omental mass. The Pathology Department of the hospital could not make a definitive diagnosis at that time, and the tumor was considered a cancer of unknown primary (CUP) origin with features of primary colorectal cancer based on the immunohistochemistry (IHC) findings of the biopsy specimen (CK7–/CK20+ and CDX-2+). He was then referred to our hospital. We found that serum ?-fetoprotein was abnormally elevated to 7,144 ng/ml (normal <10.0), and reevaluation of the biopsy specimen revealed microcystic or reticular patterns of tumor cells with Schiller-Duval bodies typical of YST. The present case suggests that IHC is a very useful diagnostic tool for subtyping CUP but should be interpreted in the context of clinical and morphological findings.

Harano, Kenichi; Ando, Masashi; Sasajima, Yuko; Yunokawa, Mayu; Yonemori, Kan; Shimizu, Chikako; Tamura, Kenji; Katsumata, Noriyuki; Tsuda, Hitoshi; Fujiwara, Yasuhiro

2012-01-01

32

Primary paratesticular yolk sac tumor: A case report and review of literature  

PubMed Central

Paratesticular germ cell tumors are extremely rare. A 12-month-old boy with yolk sac tumor involving only the paratesticular tissue is reported. Pre-operatively raised alpha fetoprotein levels fell to normal levels after high inguinal orchiectomy. This appears to be the youngest and only the 3rd case reported in the English literature.

Lyngdoh, Toijam Soni; Menon, Prema; Jain, Richa; Das, Ashim

2013-01-01

33

Flap reconstruction and hyperbaric oxygen therapy in the management of temporal bone osteoradionecrosis in an endolymphatic sac tumor: case report.  

PubMed

Endolymphatic sac tumors (ELSTs) are rare neuroectodermal neoplasms arising within the posterior petrous bone. We present a case of a 21-year-old man who presented with a 6-month history of intermittent morning headaches, fatigue, diplopia, and gait ataxia. Imaging and surgical pathology identified an adenocarcinoma of the endolymphatic sac compressing the cerebellum and brain stem. The tumor and multiple metastases were treated with surgery, radiation, and radiosurgery. Following insertion of a ventriculoperitoneal shunt for hydrocephalus, he developed symptomatic tension pneumocephalus secondary to radionecrosis of his petrous bone, requiring flap reconstruction and use of a programmable shunt valve complemented by hyperbaric oxygen (HBO) therapy. We document here a young patient with a rare adenocarcinoma of the endolymphatic sac. This case is unique for its initial presentation without any vestibuloauditory symptoms. Metastatic spread of ELSTs is also rare. While osteoradionecrosis (ORN) of the temporal bone has been reported previously in patients with nasopharyngeal carcinoma, this is the first time it has been presented in the context of an ELST. Tension pneumocephalus is a rare complication of skull base ORN. This is the first reported use of a programmable shunt valve and HBO therapy in the management of tension pneumocephalus. PMID:23984214

Guha, Daipayan; Menard, Cynthia; Evans, Wayne; Gentili, Fred; Zadeh, Gelareh

2011-11-01

34

Flap Reconstruction and Hyperbaric Oxygen Therapy in the Management of Temporal Bone Osteoradionecrosis in an Endolymphatic Sac Tumor: Case Report  

PubMed Central

Endolymphatic sac tumors (ELSTs) are rare neuroectodermal neoplasms arising within the posterior petrous bone. We present a case of a 21-year-old man who presented with a 6-month history of intermittent morning headaches, fatigue, diplopia, and gait ataxia. Imaging and surgical pathology identified an adenocarcinoma of the endolymphatic sac compressing the cerebellum and brain stem. The tumor and multiple metastases were treated with surgery, radiation, and radiosurgery. Following insertion of a ventriculoperitoneal shunt for hydrocephalus, he developed symptomatic tension pneumocephalus secondary to radionecrosis of his petrous bone, requiring flap reconstruction and use of a programmable shunt valve complemented by hyperbaric oxygen (HBO) therapy. We document here a young patient with a rare adenocarcinoma of the endolymphatic sac. This case is unique for its initial presentation without any vestibuloauditory symptoms. Metastatic spread of ELSTs is also rare. While osteoradionecrosis (ORN) of the temporal bone has been reported previously in patients with nasopharyngeal carcinoma, this is the first time it has been presented in the context of an ELST. Tension pneumocephalus is a rare complication of skull base ORN. This is the first reported use of a programmable shunt valve and HBO therapy in the management of tension pneumocephalus.

Guha, Daipayan; Menard, Cynthia; Evans, Wayne; Gentili, Fred; Zadeh, Gelareh

2011-01-01

35

Primary spinal yolk sac tumor with brain metastasis: case report and review of the literature  

Microsoft Academic Search

SummaryObject  Central nervous system primary germ cell tumors are typically pineal or suprasellar. Primary germ cell tumors of the spinal axis are very rare, with only a few case reports of germinomas and teratomas described in the literature.Methods  We present the unique case of a 25-year-old woman with an intradural, extramedullary primary yolk sac tumor (YST) at and below the level of

Peter Kan; Oren N. Gottfried; Deborah T. Blumenthal; James K. Liu; Karen L. Salzman; Jeannette Townsend; Randy L. Jensen

2006-01-01

36

Tenosynovial Giant Cell Tumor Arising on the Scapular Region  

PubMed Central

Tenosynovial giant cell tumor (TSGCT) is a benign soft tissue tumor arising from the synovial membrane that composes the lining of joints, tendons and bursae. TSGCT is a common tumor occurring in the hands and fingers, and also consecutively in the knees, ankles, feet and hips. It is rarely found in the scapular region. To the best of our knowledge, only 2 cases arising on the upper back have been reported. This report presents the case of a 44-year-old Japanese female with a TSGCT arising on her right scapular region.

Fukuda, Asako; Ueno, Takashi; Takayama, Ryoko; Ansai, Shin-ichi; Futagami, Ayako; Kawana, Seiji

2013-01-01

37

Ewing's Sarcoma of the Lesser Sac Masquerading as a Pancreatic Tumor  

PubMed Central

Extraosseous Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is an uncommon, aggressive, and malignant tumor with a poor patient outcome. Its occurrence in the lesser sac is a rare event and to the best of our knowledge, has not been previously described. The present case was clinically and radiologically misdiagnosed as a pancreatic tumor/gastrointestinal stromal tumor. Histopathology revealed a tumor with "small round cells" that were positive for CD99, confirming the diagnosis of ES/PNET. This report highlights the importance of considering Ewing's sarcoma in the differential diagnosis of intraabdominal, extraintestinal masses.

Rao, Lakshmi; Rodrigues, Gabriel; Suresh, B P

2012-01-01

38

Gonadoblastoma and hepatoid and endometrioid-like yolk sac tumor: an update.  

PubMed

Dr Robert E. Scully greatly advanced our understanding of germ cell neoplasia to the extent that it is difficult to narrow the discussion of his contributions to this topic so that it can be covered in a brief article. This article accordingly focuses on some of the recent developments concerning 2 of his major contributions in this area-the gonadoblastoma (GB) and variant morphologies of yolk sac tumor. GB was defined by Dr Scully in 1953 and its features elaborated in detail by him in 1970. This neoplasm occurred in young patients who often displayed phenotypic sex ambiguities and frequently presented with primary amenorrhea. It was bilateral in 40%, and consisted of circumscribed nests of small sex cord cells and germinoma-like cells admixed with round deposits of eosinophilic, hyaline, often calcified material. These nests were set in a spindle cell gonadal stroma with Leydig-like or lutein-like cells. Because of his work we now understand that this precursor to invasive germ cell tumors occurs in patients with a specific form of disorder of sex development, namely gonadal dysgenesis, and only in those who have a particular portion of the Y chromosome, the GB locus/TSPY gene, within the gonadal tissue. An essential element to the development of GB appears to be a defect in the genetic pathway that leads to the development of Sertoli cells. Improperly formed Sertoli cells predispose to "delayed maturation" of the gonocytes of the gonad and predispose them to undergo malignant transformation. "Undifferentiated gonadal tissue" has been proposed as the precursor to the development of GB and consists of an unorganized mixture of apparently non-neoplastic germ cells, germ cells with delayed maturation, and neoplastic germ cells with sex cord cells and gonadal stroma. Two variant morphologies of yolk sac tumor were also recognized by Dr Scully. In the hepatoid variant features similar to hepatocellular carcinoma occurred, although primitive glandular foci and lack of liver involvement permitted its distinction in most cases. More recently this variant has been found to occasionally produce bile in canalicular-like structures and to stain strongly for both SALL4 and glypican 3, 2 recently described markers of yolk sac tumor. Recognition of hepatoid yolk sac tumor was followed by the description of a potential mimic, primary ovarian hepatoid carcinoma, which, however, occurred in a significantly older patient population and was occasionally associated with surface epithelial neoplasia. The endometrioid-like variant of yolk sac tumor simulated primary endometrioid adenocarcinoma. It can be suspected on routine stains because of primitive appearing nuclei, frequent subnuclear vacuoles, and in some cases association with more usual yolk sac tumor. Its recognition is now facilitated by a panel of immunohistochemical stains that are often expressed differentially in these 2 neoplasms-endometrioid-like yolk sac tumor: positive for SALL4, glypican 3, and ?-fetoprotein; endometrioid adenocarcinoma: positive for cytokeratin 7 and epithelial membrane antigen. Finally, Dr Scully contributed one of the first cases in the literature of yet another nuance in the complicated world of yolk sac neoplasia, namely the development of some tumors on the background of a surface epithelial neoplasm. This is analogous to the more common development of choriocarcinoma from carcinoma and, in the case of yolk sac tumor, diagnosis is aided clinically by the usual older age of the patient and nature of the associated neoplasia. PMID:24901396

Ulbright, Thomas M

2014-07-01

39

Characterization of a complex chromosome aberration in two cases of peritoneal mesothelioma arising primarily in the hernial sac.  

PubMed

Malignant mesotheliomas of the hernial sac are uncommon and only a few cases have been diagnosed incidentally during herniorrhaphy procedures. The prognosis is poor and patient management is difficult because current treatment modalities do little to prolong survival. Molecular markers could be useful to identify potential therapeutic targets. Using microarray-comparative genomic hybridization (aCGH), two cases of peritoneal mesothelioma that were found incidentally at the time of hernia repair, were investigated. A high number of genetic aberrations was detected in both cases. The gains were prevalent. The tumors showed identical lost regions at 2q13, 6q25.3, 6q26, 6q26-->q27, 9q31.1-->9q31.3, 10p15.3, 11q13.2, 13q14.2, 19q13.42-->q43, and gains at 1p36.33, 3q29, 5p15.33, 7p22.3, 10p15.1-->10p14, 11q13.2, 12q24.23, 12q24.33, 16p13.3, 17p13.3, 18p11.31, 19q13.43, 21q21.1-->q21.2, 22q11.1-->q11.22, Xp21.2, Xq28. Survival was longer in the patient with a lower total number of genetic defects. aCGH provides a high-resolution map of copy number changes that may be critical to mesothelioma progression. PMID:19490474

Serio, Gabriella; Gentile, Mattia; Pennella, Antonio; Marzullo, Andrea; Buonadonna, Antonia Lucia; Nazzaro, Pietro; Testini, Mario; Musti, Marina; Scattone, Anna

2009-06-01

40

Evaluation of cloned cells, animal model, and ATRA sensitivity of human testicular yolk sac tumor  

PubMed Central

The testicular yolk sac tumor (TYST) is the most common neoplasm originated from germ cells differentiated abnormally, a major part of pediatric malignant testicular tumors. The present study aimed at developing and validating the in vitro and vivo models of TYST and evaluating the sensitivity of TYST to treatments, by cloning human TYST cells and investigating the histology, ultra-structure, growth kinetics and expression of specific proteins of cloned cells. We found biological characteristics of cloned TYST cells were similar to the yolk sac tumor and differentiated from the columnar to glandular-like or goblet cells-like cells. Chromosomes for tumor identification in each passage met nature of the primary tumor. TYST cells were more sensitive to all-trans-retinoic acid which had significantly inhibitory effects on cell proliferation. Cisplatin induced apoptosis of TYST cells through the activation of p53 expression and down-regulation of Bcl- expression. Thus, we believe that cloned TYST cells and the animal model developed here are useful to understand the molecular mechanism of TYST cells and develop potential therapies for human TYST.

2012-01-01

41

Melanotic neuroectodermal tumor of infancy disseminated by a ventriculoperitoneal shunt and diagnosed from the inguinal sac.  

PubMed

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare congenital neoplasm that originates from the neural crest cells, which give rise to the melanocytes of the skin and leptomeninges. We report a case of MNTI with neurocutaneous melanosis of a 28-month-old girl. She was born with hydrocephalus and several large congenital giant nevi. There were no findings except for hydrocephalus, after a ventriculoperitoneal (VP) shunt operation performed when she was 6 months old. She was operated on for a growing inguinal mass at 8 months. The specimen from the inguinal sac was positive for HMB45, vimentin, chromogranin, and neuron-specific enolase. Brain magnetic resonance imaging showed an extensive enhancing extra-axial mass with high signal intensity, along the cerebral spinal fluid space. We report a rare case of MNTI, diagnosed from an inguinal hernia sac, with a disseminated clinical manifestation. PMID:23823108

Yoo, In Hyuk; Yum, Sook Kyung; Oh, Se-Jeong; Kim, Kyoung-Mee; Jeong, Dae Chul

2014-01-01

42

Long-term outcome and prognostic factors for yolk sac tumor of the ovary.  

PubMed

Yolk sac tumors of the ovary (YST) are rare and highly malignant tumors occurring in children and young adults. Because of its rarity, YST prognostic factors remain unclear. Our purpose was to evaluate the prognostic factors in YST. We performed a retrospective review of 36 patients with pure YST from 1986 to 2006. The 5-year overall survival and progression-free survival were 66.6% and 68.8%, respectively. Patients with stage I-II disease had a more favorable prognosis than those with stage III-IV (p < 0.05). Those with an ascites volume of less than 100 ml or a residual tumor measuring less than 1 cm had improved to a relatively good prognosis. Neither serum AFP level nor age had any significant correlation with the prognosis in this study. In conclusion, the FIGO (International Federation of Gynecology and Obstetrics) stage, ascites volume and residual tumor size tended to affect the prognosis of YST. PMID:18807293

Umezu, Tomokazu; Kajiyama, Hiroaki; Terauchi, Mikio; Shibata, Kiyosumi; Ino, Kazuhiko; Nawa, Akihiro; Kikkawa, Fumitaka

2008-03-01

43

Regulatory role of CCAAT/enhancer binding protein-beta in the production of plasma proteins in yolk sac tumor.  

PubMed

Yolk sac tumor (endodermal sinus tumor) is a malignant germ cell tumor characterized by AFP production, in which histologic foci similar to hepatocellular carcinoma occasionally coexist. We assumed a possible contribution of CCAAT/enhancer binding protein (C/EBP)-beta, a transcription factor implicated in the regulation of plasma proteins in the liver, to the regulation of AFP production and to the expression of other plasma proteins in yolk sac tumor cells because our immunohistochemical analysis revealed nuclear expression of C/EBP-beta in human yolk sac tumors. Overexpression of C/EBP-beta in a rat yolk sac tumor cell line, AT-2-TC, increased production of AFP and other plasma proteins, including albumin, alpha-1-antitrypsin, hepatoglobin, and transferrin. Liver-enriched transcription factors, including hepatocyte nuclear factors (HNF)-1alpha, -1 beta, and -4, were also induced. The induction of this protein expression was only evident in xenografts, where C/EBP-beta was phosphorylated and the activating isoform of C/EBP-beta was relatively predominant. These results indicate that C/EBP-beta plays a role in the production of plasma proteins of yolk sac tumors. PMID:15924879

Hirashiki, Koichiro; Kishimoto, Takashi; Ishiguro, Hiroshi; Nagai, Yuichiro; Furuya, Mitsuko; Sekiya, Soei; Ishikura, Hiroshi

2005-06-01

44

Primary yolk sac tumor of the retroperitoneum: A case report and review of the literature  

PubMed Central

Yolk sac tumor (YST), also known as an endodermal sinus tumor, is a rare malignant germ cell tumor. Primary retroperitoneal YST (PRYST) is extremely rare and, to the best of our knowledge, has only been described in case reports. The histogenesis of PRYST and the appropriate treatment strategy remain unclear due to the rarity of this type of tumor. The present study reports a case of YST in the retroperitoneum. A 19-year-old female presented with abdominal distension and edema of the lower limbs. A computed tomography scan revealed a large, solid mass located in the retroperitoneum. The tumor size was 20×25×30 cm and widespread metastasis was identified during the exploratory laparotomy. The postoperative histopathology report showed a malignant retroperitoneal tumor (although a YST was initially considered). The patient underwent three surgical procedures and 17 cycles of five different chemotherapy regimens. The patient succumbed to cachexia, which was due to tumor recurrence, and liver and spleen metastases 21 months after diagnosis. PRYST may relapse following surgical treatment; however, surgical resection is currently the optimal treatment method. In this case, bleomycin, etoposide and cisplatin; bleomycin, vincristine and cisplatin; and vincristine and cisplatin chemotherapy regimens were effective for the patient with PRYST, although the tumor was not completely resected. ?-fetoprotein (AFP) is an important tumor marker for monitoring PRYST recurrence and observation of elevated serum AFP levels during chemotherapy indicates a poor prognosis.

GUO, YANG-LONG; ZHANG, YING-LI; ZHU, JIAN-QING

2014-01-01

45

A case of ovarian endometrioid adenocarcinoma with a yolk sac tumor component.  

PubMed

Endometrioid adenocarcinoma of the ovary coexists very rarely with yolk sac tumor (YST). This unusual mixed tumor is thought to be a rare variant of endometrioid ovarian carcinoma because of its aggressive behavior, lack of response to chemotherapy, and unfavorable prognosis. We report a case of ovarian endometrioid adenocarcinoma with a YST component in a postmenopausal woman. The patient was treated by surgery and a combination of bleomycin, etoposide, and cisplatin and taxol and carboplatin. She has been clinically free of tumor for 20 months. Immunohistochemically, the YST component reacted for alpha-fetoprotein. YST areas were negative for both CA125 and sex-hormone receptors. Cytokeratin7 and epithelial membrane antigen were negative in YST, but positive in endometrioid adenocarcinoma. The occurrence of this unusual case suggests that even somatic carcinomas may acquire an extraembryonal germ cell differentiation. PMID:17466041

Abe, A; Furumoto, H; Yoshida, K; Nishimura, M; Irahara, M; Kudo, E; Sano, T

2008-01-01

46

CDX2 expression in yolk sac component of testicular germ cell tumors.  

PubMed

CDX2 has been detected in the majority of colorectal adenocarcinoma cases and may be useful in determining the sites of origin of tumors. In this study, the authors evaluated CDX2 expression in germ cell tumors (GCTs) by immunohistochemistry. Forty cases of testicular GCTs and 8 cases of metastatic GCTs were retrieved for study. In the 40 cases of testicular GCTs, 13 were pure seminomas and 27 mixed GCTs. Yolk sac tumor (YST) was identified by morphology and glypican 3 staining in 20 testicular mixed GCTs. Of these 20 cases, 8 cases showed 1+ positivity for CDX2. Other primitive components of GCTs were negative. For the 6 cases of metastatic mixed GCT with YST, 4 cases were positive, 2+ in 2 cases and 1+ in 2 cases. The positivity of CDX2 in GCTs warrants including YST in the differential diagnosis of adenocarcinoma of unknown origin. PMID:19578052

Bing, Zhanyong; Pasha, Theresa; Tomaszewski, John E; Zhang, Paul

2009-10-01

47

Left ovarian gonadoblastoma with yolk sac tumor in a young woman.  

PubMed

Gonodoblastomas with ovarian germ cell tumors other than dysgerminoma coexists very rarely with yolk sac tumor (YST). Because of this rarity, we report a case of gonadoblastoma with YST. An 18-year-old female patient was admitted to our hospital with an abdomino-pelvic mass. Ultrasonographical examinations revealed a 15X14 cm heterogenous pelvic mass with calcific foci in the left adnexal area. Macroscopically, the resected mass was oval and measured 18X15X15 cm and weighed 3150 gm. Histological examination showed both gonadoblastic and YST areas. There were many gonadoblastic nests in the subcapsular areas of the tumor. The gonadoblastic nests were composed of large and small cells. The YST areas showed enteric differentiation and numerous hyaline globules. Immunohistochemical examination may help in the diagnosis of these gonadoblastoma with YST. PMID:20551554

Gelincik, Ibrahim; Ozen, Suleyman; Bayram, Irfan

2010-01-01

48

A unique case of a sarcoma arising in a testicular non-seminomatous mixed germ cell tumour with a predominant yolk sac component.  

PubMed

We present a unique case of a sarcoma arising in a testicular non-seminomatous mixed germ cell tumour with a predominant yolk sac tumour (YST) component. This is the first case reported in which a sarcoma is linked to YST of the testis in a patient not having undergone prior chemotherapy. This finding confirms the ability of YST to contain sarcoma; it underlies its importance for urologists, oncologists and pathologists to be aware of this phenomenon and to modify treatment strategies appropriately. PMID:21989175

Lavallée, Luke T; Roustan Delatour, Nicolas Ld; Cagiannos, Ilias; Bélanger, Eric C; Mai, Kien T

2011-10-01

49

Testicular yolk sac tumor of myxomatous, reticular, and polyvesicular vitelline type in a newborn calf.  

PubMed

Yolk sac tumors (YSTs) are rare neoplasms of germ cell origin. In humans, the tumors primarily occur in the testes or ovaries, but occasionally develop at other sites. The neoplastic cells of YSTs form many histological patterns resembling embryonal structures, and the World Health Organization classification lists 11 such patterns: reticular, macrocystic, endodermal sinus, papillary, solid, glandular-alveolar, myxomatous, sarcomatoid, polyvesicular vitelline, hepatoid, and parietal. Among domestic animals, only 2 cases of YST, which were of testicular and abdominal cavity origin, have been reported in calves. In both cases, neoplastic cells had epithelial properties and disseminated metastases in the abdomen. In the present study, the enlarged testis of a newborn calf, which was subsequently diagnosed as YST and exhibited myxomatous, reticular, and polyvesicular vitelline histological patterns, is described. There was no metastasis in this case, and histological and immunohistochemical features varied from previous cases of YST. PMID:24153035

Sakaguchi, Kanako; Matsuda, Kazuya; Suzuki, Hiromi; Yamamoto, Nao; Kondo, Yumi; Ando, Takaaki; Koiwa, Masateru; Kagawa, Yumiko; Taniyama, Hiroyuki

2013-11-01

50

Advanced extragonadal yolk sac tumor serially followed up with (18)F-fluorodexyglucose-positoron emission tomography and computerized tomography and serum alpha-fetoprotein.  

PubMed

Although yolk sac tumors (YSTs) are the second most common malignant germ cell tumor of the ovary, those arising from the omentum or pelvic peritoneum are extremely rare and have no established treatment guidelines. We report a case of a primary YST disseminated throughout the abdomen and associated with a high serum alpha-fetoprotein (AFP) elevation (441 611 ng/ml). Optimal cytoreduction was not achieved in order to preserve the patient's fertility and avoid adjacent organ injury. Residual tumor responded to adjuvant chemotherapy with a sharp decline in AFP levels, and confirmed remission was documented by serial (18)F-fluorodexyglucose-positoron emission tomography and computerized tomography (FDG-PET/CT). In cases of advanced YST with unresectable residual disease, AFP levels combined with FDG-PET/CT scans may be a helpful way to monitor treatment response and assist in treatment planning for a disease that primarily affects young women who may desire to preserve fertility. PMID:22353601

Baba, Tsukasa; Su, Saori; Umeoka, Shigeaki; Abiko, Kaoru; Nakamoto, Yuji; Mandai, Masaki; Matsumura, Noriomi; Konishi, Ikuo

2012-03-01

51

Bleomycin-induced pulmonary fibrosis after tumor lysis syndrome in a case of advanced yolk sac tumor treated with bleomycin, etoposide and cisplatin (BEP) chemotherapy.  

PubMed

Ovarian yolk sac tumor (YST) is a highly aggressive malignancy arising in young women. Chemotherapy has dramatically improved the prognosis, and bleomycin, etoposide, and cisplatin (BEP) combination chemotherapy appears to be the most effective combination regimen. A 23-year-old woman was admitted to our hospital with worsening abdominal distention and a lower abdominal mass. She was diagnosed with a stage IIIc pure YST of the right ovary, and right salpingo-oophorectomy was performed; there were numerous disseminated peritoneal tumors within the abdominal cavity. A few days postoperatively, massive ascites developed, and right hydronephrosis occurred. Chemotherapy with BEP was started, and after 24 h of administration, oliguria and tumor lysis syndrome (TLS) developed. Continuous hemodiafiltration was started, and hemodialysis was initiated following full-dose standard cisplatin and etoposide on days 2-5 of the 1st cycle. After the electrolyte abnormalities and the elevation of creatinine became normal, the patient received an additional three cycles of BEP and achieved complete remission. However, she also suffered from severe non-hematological toxicities, including grade 3 left ventricular dysfunction and grade 4 pulmonary fibrosis. In the case of rapidly progressing and high-volume YST treated with BEP chemotherapy, special attention should be paid to bleomycin-induced pulmonary toxicity following TLS. Further study is required to optimize drug exposure to ensure efficacy and reduce the risk of side effects in this population. PMID:22127348

Doi, Mihoko; Okamoto, Yohei; Yamauchi, Masami; Naitou, Hiroyuki; Shinozaki, Katsunori

2012-10-01

52

Yolk sac tumor with a prominent polyvesicular vitelline pattern: a report of three cases.  

PubMed

We report 3 cases of the rare polyvesicular vitelline variant of ovarian yolk sac tumor (YST). The patients were 23, 29, and 43 years old, and all presented with large unilateral adnexal masses confined to the ovary. One tumor was predominantly cystic, and the other 2 had prominent cystic components; all 3 also had solid components. Microscopic examination of the cystic regions showed dilated cysts that largely effaced the stroma resulting in a honeycomb-like appearance. The solid foci were characterized predominantly by small tubules in a fibrous stroma; the tubules exhibited variably conspicuous cystic dilatation to merge with the microcystic appearance. The tumor cells varied from large and primitive-appearing to flattened and deceptively innocuous when lining large cysts. They were immunoreactive for ?-fetoprotein and glypican-3. Non-polyvesicular vitelline components of YST were present focally in 2 cases (hepatoid in one, reticular and endometrioid like in the second). Two patients are disease free after 20 and 26 years, respectively; disease-free follow-up is of short duration in the third case (2 years). The good long-term outcome in 2 cases supports prior evidence that suggests that the natural history of this form of YST may be more indolent than conventional forms of the tumor. PMID:23348213

Young, Robert H; Ulbright, Thomas M; Policarpio-Nicolas, Maria Luisa C

2013-03-01

53

Yolk sac tumor of the vulva: a case report with recurrence after long-term follow-up.  

PubMed

A yolk sac tumor (YST) of the vulva is extremely rare and highly malignant with recurrence frequently occurring within a year. This report presents the 13th known case of vulvar YST, with recurrence occurring after the longest known follow-up period so far reported in the literature. PMID:22868632

Mochizuki, Kyoko; Obatake, Masayuki; Taura, Yasuaki; Inamura, Yukio; Takatsuki, Mitsuhisa; Nagayasu, Takeshi; Eguchi, Susumu

2012-09-01

54

Testicular seminoma after the complete remission of extragonadal yolk sac tumor : a case report  

PubMed Central

Background Between 2% and 5% of malignant germ-cell tumors in men arise at extragonadal sites. Of extragonadal germ cell tumors, testicular carcinoma in situ (CIS) are present in 31–42% of cases, and CIS are reported to have low sensitivity to chemotherapy in spite of the various morphology and to have a high likelihood of developing into testicular tumors. A testicular biopsy may thus be highly advisable when evaluating an extragonadal germ cell tumor. Case presentation A 36-year-old man was diagnosed as having an extragonadal non-seminomatous germ cell tumor, that was treated by cisplatin-based chemotherapy, leading to a complete remission. In the meantime, testicular tumors were not detected by means of ultrasonography. About 4 years later, a right testicular tumor was found, and orchiectomy was carried out. Microscopically, the tumor was composed of seminoma. Conclusions We herein report a case of metachronous occurrence of an extragonadal and gonadal germ cell tumor. In the evaluation of an extragonadal germ cell tumor, a histological examination should be included since ultrasonography is not sufficient to detect CIS or minute lesions of the testis.

Kuroda, Isao; Ueno, Munehisa; Mitsuhashi, Tomoko; Nakagawa, Ken; Yanaihara, Hitoshi; Tsukamoto, Takuji; Deguchi, Nobuhiro

2004-01-01

55

Oncofetal protein glypican-3 distinguishes yolk sac tumor from clear cell carcinoma of the ovary.  

PubMed

Clear cell carcinoma (CCC) of the ovary is the surface epithelial neoplasm most often confused with primitive germ cell tumors, particularly yolk sac tumor (YST) and dysgerminoma. OCT3/4 has proven to be a sensitive and relatively specific marker for the latter entity, but existing markers for YST are limited. Recent studies suggest that glypican-3 (GPC3), an oncofetal protein expressed in fetal liver and malignant tumors of hepatocytic lineage, is also expressed in germ cell tumors, particularly YST. To investigate whether GPC3 is useful in distinguishing YST from ovarian CCC, we studied the expression of GPC3 in a large series of ovarian neoplasms and compared it to the expression profiles of CK7 and alpha-fetoprotein. Tissue microarrays containing over 400 benign and malignant ovarian neoplasms, including 34 CCCs were stained with monoclonal GPC3 (clone 1G12, Biomosaics, Burlington, VT). These arrays contained a wide assortment of ovarian surface epithelial neoplasms and sex cord stromal neoplasms, as well as germ cell tumors. Full paraffin tissue sections from 32 YSTs and 10 CCCs were also assessed. All but one YST (97%), including those associated with mixed germ cell tumor were positive for GPC3, whereas all teratomas and embryonal carcinomas were negative. Both cytoplasmic and membrane staining were present in the positive cases, with no background staining. The syncytiotrophoblastic cells in the germ cell tumors and placental villi included in the arrays were also positive for GPC3. Most CCCs (83%) were completely negative for GPC3, as were 99% serous, 94% endometrioid, and 100% mucinous tumors. Five CCCs exhibited focal, moderate to strong GPC3 expression and in 2 the expression was focal and weak. All other tissues, including normal ovary were negative for GPC3. GPC3 seems to be a promising diagnostic marker for differentiating YST from ovarian CCC (P < 0.0001). Because GPC3 may be associated with alpha-fetoprotein expression, further studies are required to determine the utility of GPC3 in differentiating YST from CCC with hepatoid differentiation. PMID:18277882

Esheba, Ghada E; Pate, Lisa L; Longacre, Teri A

2008-04-01

56

Adult Nasolacrimal Sac Mucocele  

Microsoft Academic Search

Adult nasolacrimal sac mucocele is an uncommon mass arising in the medial canthal region of the orbit. Twenty-one cases with lacrimal sac mucocele were reviewed retrospectively. We gathered information about the clinical characteristics, natural history, mechanism for mucocele formation and optimal management of this disorder. The results show that the medial canthal mass was confirmed to be dacryocystocele-associated with distal

M. Y. Xiao; L. S. Tang; H. Zhu; Y. J. Li; H. L. Li; X. R. Wu

2008-01-01

57

Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell.  

PubMed

A 21-year-old lady diagnosed with Stage 3 ovarian yolk sac tumor (YST) underwent primary cytoreductive fertility sparing surgery, followed by conventional courses of platinum-based chemotherapy and etoposide. Recurrence at cul-da-sac was noted after a short period of remission and secondary debulking performed followed by four cycles of conventional chemotherapy. The patient's disease progressed despite courses of treatments. A joint team management including a hematologist was commenced following the failure of conventional chemotherapies. Two cycles of high-dose chemotherapy (HDCT) with ifosfamide/cisplatin/etoposide (ICE) regimen, followed by autologous stem cell transplantation (ASCT) were given. With this salvage treatment, she remained in complete remission and disease-free for more than 30 months, while maintaining her reproductive function. These approaches appear to be effective as a salvage treatment in selected cases of patients with ovarian germ cell tumor, especially those who failed primary conventional chemotherapy. PMID:23781595

Abdullah, N A; Wang, P N; Huang, K G; Adlan, A S; Casanova, J

2013-01-01

58

Adult nasolacrimal sac mucocele.  

PubMed

Adult nasolacrimal sac mucocele is an uncommon mass arising in the medial canthal region of the orbit. Twenty-one cases with lacrimal sac mucocele were reviewed retrospectively. We gathered information about the clinical characteristics, natural history, mechanism for mucocele formation and optimal management of this disorder. The results show that the medial canthal mass was confirmed to be dacryo-cystocele-associated with distal nasolacrimal duct obstruction and proximal obstruction at the junction of the common canaliculus and sac. The interventional procedure of polyurethane stent placement is a practicable and simplified treatment for lacrimal sac mucocele. PMID:18097176

Xiao, M Y; Tang, L S; Zhu, H; Li, Y J; Li, H L; Wu, X R

2008-01-01

59

A tenosynovial giant cell tumor arising from femoral attachment of the anterior cruciate ligament.  

PubMed

The localized type of tenosynovial giant cell tumor usually occurs on the palmar side of fingers and toes. Tenosynovial giant cell tumors of the tendon sheath are rarely intra-articular. We report a giant cell tumor of the tendon sheath arising from femoral attachment of the anterior cruciate ligament and its treatment with arthroscopy in a 28-year-old man. PMID:24900909

Lee, Ju-Hong; Wang, Seong-Il

2014-06-01

60

A Tenosynovial Giant Cell Tumor Arising from Femoral Attachment of the Anterior Cruciate Ligament  

PubMed Central

The localized type of tenosynovial giant cell tumor usually occurs on the palmar side of fingers and toes. Tenosynovial giant cell tumors of the tendon sheath are rarely intra-articular. We report a giant cell tumor of the tendon sheath arising from femoral attachment of the anterior cruciate ligament and its treatment with arthroscopy in a 28-year-old man.

Lee, Ju-Hong

2014-01-01

61

Yolk sac tumor of the ovary: a retrospective multicenter study of 33 Japanese women by Tohoku Gynecologic Cancer Unit (TGCU).  

PubMed

Yolk sac tumor (YST) of the ovary is a rare germ cell tumor comprising about 1% of all ovarian malignancies. YST usually occurs as a rapidly growing unilateral tumor in young women. With the introduction of cisplatin, YST has been changed from a fatal tumor to a curable tumor. The standard treatment of YST consists of fertility-preserving surgery and 3 or 4 courses of adjuvant combination chemotherapy with bleomycin, etoposide, and cisplatin (BEP). However, the long-term prognosis of BEP-treated YST patients has not been well studied. We therefore conducted a retrospective multicenter study to investigate the prognostic factors of 33 YST patients, including 25 patients treated with BEP. The median age at initial treatment was 20 years (range 10-53). There were 15 patients (at stage I), one (stage II), 16 (stage III), and one (stage IV). Nominal and grouped numerical values were analyzed by the Kaplan-Meier method. All patients had unilateral tumor, with right-side predominance (23 patients; P = 0.02). Eighteen patients had pure YST, 13 had mixed germ cell tumor with YST component, and other 2 patients were not specified. Twenty-eight patients received fertility-preserving surgery. Twenty-seven patients had optimal surgery with less than 1 cm residual tumor diameter. Median number of chemotherapy courses was 5. Median follow-up period was 49 months. The cumulative 5-year survival rate was 87%. Univariate analysis revealed the following significant prognostic factors (P < 0.05): stage, tumor diameter, and residual tumor. Extensive debulking surgery to minimize residual tumor would improve the prognosis. PMID:23912096

Kojimahara, Takanobu; Nakahara, Kenji; Takano, Tadao; Yaegashi, Nobuo; Nishiyama, Hiroshi; Fujimori, Keiya; Sato, Naoki; Terada, Yukihiro; Tase, Toru; Yokoyama, Yoshihito; Mizunuma, Hideki; Shoji, Tadahiro; Sugiyama, Toru; Kurachi, Hirohisa

2013-01-01

62

A case of ovarian endometrioid adenocarcinoma with yolk sac tumor in a 35-year-old woman.  

PubMed

Ovarian yolk sac tumor (YST) is a malignant ovarian neoplasm differentiated from primordial germ cells that occur in young age, while endometrioid carcinoma (ECA) is a müllerian epithelial tumor that usually occurs in older patients. The coexistence of an ovarian ECA and YST component is very rare. Only 12 cases have been reported until now according to a Medline search of the English literatures. We present a case of a simultaneous ECA and a YST component in a 35-year-old woman. Exploratory laparotomy was performed. The parts of both ovaries that showed an endometrioid-like glandular pattern were positive for cytokeratin 7 and negative for AFP, but the YST component was negative for cytokeratin 7 and positive for AFP. After completion of four courses of BEP chemotherapy, two courses of taxane and carboplatin chemotherapy were added. The patient failed to respond and succumbed to the disease after 12 months of follow-up. PMID:20882900

Hong, D G; Chong, G O; Seong, W J; Lee, Y S; Cho, Y L; Park, J Y; Chae, J M; Park, I S

2010-01-01

63

Evaluation of an anal sac adenocarcinoma tumor in a Spitz dog.  

PubMed

A 9-year-old emasculated male Spitz with tenesmus and constipation had a subcutaneous mass at the left ventral aspect of the anus with history of polyuria and polydipsia. A complete blood cell count, serum biochemistry panel, and urinalysis (cystocentesis sample) were evaluated. Abnormalities in the serum biochemistry panel included a mildly elevated serum cholesterol concentration (7.28 mmol/L; reference interval, 2.70-5.94 mmol/L), increased serum alkaline phosphatase activity (184 U/L; reference interval, 9-90 U/L), alanine transaminase (122 U/L; reference interval, 5-60 U/L) activity and aspartate aminotransferase (80 U/L; reference interval, 5-55 U/L) activity, severe increased total calcium concentration (16.3 mg/dL; reference interval, 8.2-12.4 mg/dL or 9.3-11.4 mg/dL), and decreased total calcium concentration (3.4 mg/dL, reference interval, 2.5-5.6mg/dL). Furthermore, testing revealed an increased intact parathyroid hormone concentration (38.6 pmol/L; reference interval, 3-17 pmol/L). On cytologic and histopathologic examinations, various types of cells were observed. Most of the cells were oval to polygonal and had elliptical or elongate nuclei and a moderate amount of pale to basophilic cytoplasm. The remaining cells had round to oval nuclei and pale to basophilic cytoplasm. Cells of both types were loosely adhered to each other and were arranged in rosette-like structures. Both neoplastic cell types had fine homogenous chromatin and either a small indistinct nucleolus or no visible nucleolus. Mild anisokaryosis and anisocytosis were observed. Histologically, the mass consists of glandular structures formed by cuboidal cells admixed with bundles of spindle cells. Based on location and histologic features, the final diagnosis was adenocarcinoma of the apocrine gland of the anal sac, which should be included as a cytologic differential diagnosis when spindle cells and typical epithelial cells are observed in masses in the region of the anal sac of dogs. PMID:23570021

Javanbakht, Javad; Tavassoli, Abbas; Sabbagh, Atefeh; Hassan, Mehdy Aghamohammmad; Samakkhah, Shohreh Alian; Shafiee, Radmehr; Lakzian, Ali; Ghalee, Vahideh Rahmani; Gharebagh, Sonia Shoja; Imani, Abbas

2013-01-01

64

Dedifferentiated gastrointestinal stromal tumor arising de novo from the small intestine.  

PubMed

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and usually display monotonous cytologic features and immunoactivity for CD117. Anaplastic GIST, with pleomorphic cells and loss of CD117, until recently have only been reported in patients with chronic imatinib mesylate treatment. Dedifferentiated GISTs arising de novo is a newly identified entity that may prove to be difficult to diagnose. We present the case of a 52-year-old female found to have a dedifferentiated GIST without prior imatinib mesylate therapy. This case is the first reported dedifferentiated GIST arising de novo from the small bowel, and at 30cm in greatest diameter, the largest reported to date. Additionally, we demonstrate for the first time the loss of DOG1 in the anaplastic component of the tumor. De novo dedifferentiated GIST is a rare and diagnostically challenging tumor that may be mischaracterized unless considered in the differential diagnosis. PMID:24484970

Choi, Jacqueline J; Sinada-Bottros, Laura; Maker, Ajay V; Weisenberg, Elliot

2014-04-01

65

Malignant rhabdoid tumor of the kidney arising in an adult patient  

PubMed Central

Malignant rhabdoid tumors (MRT) of the kidney are rare in children and even less common in adults, with only six previously reported adult cases. We present the case of a 60-year-old man with an MRT arising in the left kidney with extensive pulmonary micrometastases and thromboembolism resulting in thrombotic pulmonary microangiopathy (pulmonary tumor embolism syndrome). MRT is an extremely aggressive neoplasm with a short survival time.

Podduturi, Varsha; Campa-Thompson, Molly M.; Zhou, Xin J.

2014-01-01

66

Malignant rhabdoid tumor of the kidney arising in an adult patient.  

PubMed

Malignant rhabdoid tumors (MRT) of the kidney are rare in children and even less common in adults, with only six previously reported adult cases. We present the case of a 60-year-old man with an MRT arising in the left kidney with extensive pulmonary micrometastases and thromboembolism resulting in thrombotic pulmonary microangiopathy (pulmonary tumor embolism syndrome). MRT is an extremely aggressive neoplasm with a short survival time. PMID:24982576

Podduturi, Varsha; Campa-Thompson, Molly M; Zhou, Xin J; Guileyardo, Joseph M

2014-07-01

67

A population-based analysis of 788 cases of yolk sac tumors: A comparison of males and females.  

PubMed

Yolk sac tumors (YST) are a rare and aggressive germ cell tumor. The objective of this study is to compare the patient characteristics and survival of YST in males and females. Demographic and clinicopathologic information were obtained from the Surveillance, Epidemiology, and End Results Program from 1973 to 2003. Statistical analysis was performed using Independent-sample t-test, chi(2) test, Kaplan-Meier methods and Cox proportional hazards regression. Seven hundred eighty-eight patients were identified, 451 (57%) were males and 337 (43%) were females. The mean age at diagnosis was similar in males and females. The age at diagnosis showed a bimodal distribution with an increased incidence in the first 4 years of life and during the 2nd to 4th decade of life. The most common site of the primary tumor was gonadal, namely testis 336 (42.6%) and ovary 257 (32.6%). Among the extragonadal sites, tumor site of origin differed in males and females. The 5-year survival of extragonadal YST (66%) was worse than gonadal YST (86%) (p < 0.05). The overall median survival for the cohort was 87 months. This was similar in males (81 months) and females (91 months) (p > 0.05). As the year of diagnosis progressed from 1973 to 2003, survival of both males and females with YST consistently improved. The bimodal age distribution of YST generates the hypothesis that sex steroids may play a role in selected YST. Although the overall survival in all YST patients has improved over the past few decades, the primary sites of origin differ in males and females and impact prognosis. PMID:18767035

Shah, Jay P; Kumar, Sanjeev; Bryant, Christopher S; Ali-Fehmi, Rouba; Malone, John M; Deppe, Gunter; Morris, Robert T

2008-12-01

68

Endometrial carcinoma with yolk sac tumor-like differentiation and elevated serum ?-hCG: a case report and literature review  

PubMed Central

Endometrial carcinoma with a germ cell tumor component is a rare event. Here we report a uterine neoplasm with a unique combination of endometrioid adenocarcinoma and mixed germ cell malignant elements. A 28-year-old woman with abnormal vaginal bleeding, an abdominal mass, and elevated alfa-fetoprotein and beta-human chorionic gonadotropin (?-hCG) levels had a history of biopsy of an omental mass and chemotherapy in another hospital one month before her referral to our department. Histologic examination of the mass removed from the omentum revealed an endometrioid adenocarcinoma with yolk sac tumor-like differentiation. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy, and removal of metastatic disease were then undertaken at our hospital. Postoperative chemotherapy was given. Eight months postoperatively, serum alfa-fetoprotein and ?-hCG rose again. Cases with primary yolk sac tumors of the endometrium or endometrial carcinoma with trophoblastic differentiation in the literature were reviewed.

Ji, Mingliang; Lu, Yan; Guo, Lina; Feng, Fengzhi; Wan, Xirun; Xiang, Yang

2013-01-01

69

Primary adenocarcinoid tumor of the ovary arising in mature cystic teratoma. A case report.  

PubMed

Primary carcinoid tumors of the ovary are rare, forming 0.3 % of all carcinoid tumors and less than 0.1 % of ovarian malignancies. We present a case of a 47-year-old woman with abnormal vaginal bleeding and abdominal discomfort. Pelvic ultrasonography revealed a right-sided, 4 cm solid ovarian mass. At laparoscopy, a smooth surfaced, firm and mobile right adnexal mass with solid and cystic portions was detected and the tumor was excised. Pathologic and immunohistochemical examination revealed carcinoid tumor. After the evaluation of gastrointestinal and respiratory systems by imaging and endoscopic studies, no evidence of tumor tissue or metastases were found. Based on this finding, total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and appendectomy were performed and pelvic-paraaortic lymph nodes were also removed. All histological findings were similar to the features of mature cystic teratoma and carcinoid tumor. Examination of the resected lymphatic, omental and appendiceal tissue indicated no tumoral invasion. Thus, the diagnosis was primary ovarian carcinoid arising from a mature cystic teratoma. This case, in the setting of a normal appendix and negative workup for an extraovarian origin, is one of a primary ovarian adenocarcinoid tumor. The primary carcinoid tumor should be differentiated from a metastatic carcinoid inside the ovary, which is always bilateral. It is important to be aware of this unusual entity in diagnoses of ovarian tumors, even in the absence of any clinical symptoms of carcinoid syndrome. PMID:19317273

Gungor, T; Altinkaya, O; Ozat, M; Sirvan, L; Yalcin, H; Mollamahmutoglu, L

2009-01-01

70

SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma.  

PubMed

Ovarian primitive germ cell tumors (GCTs) are uncommon tumors and sometimes pose diagnostic challenges. Among them, yolk sac tumor (YST) poses the greatest diagnostic difficulty and can be mistaken for clear cell carcinoma (CCC). Current immunohistochemical markers such as alpha-fetoprotein (AFP), glypican-3, cytokeratin (CK) 7, and epithelial membrane antigen (EMA) used to distinguish YST from CCC lack adequate sensitivity and specificity. Here by immunohistochemistry, we investigated a novel marker SALL4 in 98 GCTs (29 YSTs, 18 dysgerminomas, 6 gonadoblastomas, 6 embryonal carcinomas, 15 immature and 12 mature teratomas, 7 carcinoid tumors, 3 strumal carcinoids, and 2 struma ovarii) with particular interest of exploring SALL4 to distinguish YST from CCC. One hundred sixty-three non-GCTs including 45 CCCs were also stained. We found that SALL4 is strongly positive in more than 90% tumor cells in all YSTs, dysgerminomas, gonadoblastomas, and embryonal carcinomas. Variable SALL4 staining is seen in 11 of 15 immature teratomas. All other GCTs included in this study are negative for SALL4. Except 3 CCCs with focal SALL4 staining (<15% tumor cells), SALL4 is negative in the remaining 160 non-GCTs. We also compared SALL4 with AFP, glypican-3, CK7, and EMA in all YSTs and CCCs. AFP and glypican-3 are positive in 24 (83%) and 20 (69%) YSTs, respectively, whereas 16 (35%) and 13(28%) CCCs show positive AFP and glypican-3 staining, respectively. Three (10%) and 4 (14%) YSTs show focal (<2% tumor cells) CK7 and EMA staining, respectively. CK7 and EMA are positive in all 45 CCCs but 3 (7%) and 1 (2%) cases show staining in less than 30% tumor cells, respectively. Our findings indicate that SALL4 is a novel sensitive and specific marker for ovarian primitive GCTs. SALL4 is particularly useful in distinguishing YST from CCC and better than AFP, glypican-3, CK7, and EMA. PMID:19295406

Cao, Dengfeng; Guo, Shuangping; Allan, Robert W; Molberg, Kyle H; Peng, Yan

2009-06-01

71

Tumor like swellings arising from Hoffa's fat pad: A report of three patients  

PubMed Central

We report three rare cases of tumor-like conditions arising from Hoffa's fat pad (HFP). Patients were having persistent knee pain, the cause of which was not diagnosed by the general physician, and then were referred to us for knee pain. Magnetic resonance imaging revealed the lesions to be arising from HFP (ganglion cysts and hemangioma), as was suggested by clinical findings. Anatomy, pathology, and radiological features of the Hoffa's disease are described here to increase awareness in orthopedic community of this rare but interesting disease which is often misdiagnosed as meniscal pathology. These cases illustrate that increased cognizance can facilitate timely intervention which will prevent morbidity of the patient.

Ghate, Sushant D; Deokar, Bhupal N; Samant, Ashwin V; Kale, Satish P

2012-01-01

72

First Description of a Primitive Neuroectodermal Tumor Arising in the Nose  

PubMed Central

We report the case of a 12-year-old girl, who consulted us with one-year history of an 8?mm nose lesion that was painless and firm upon palpation. The lesion was resected conservatively. Immunohistochemistry was in favor of a primitive neuroectodermal tumor (PNET)/Ewing's sarcoma lesion, excluding epithelial, lymphoid, and other tumors. After a second resection, our patient was referred to chemotherapy and has already undergone 9 cycles out of 14. The patient is to date with no evidence of persistent or recurrent disease. To our knowledge, this is the first description of a PNET arising in the nose.

Rizk, Habib; Khazzaka, Aline; Sebaaly, Amer; Cherfan, Maguy; Tomb, Roland; Sarkis, Riad

2013-01-01

73

Atypical teratoid/rhabdoid tumor arising in a ganglioglioma: genetic characterization.  

PubMed

Atypical teratoid/rhabdoid tumor (AT/RT) is an uncommon, aggressive, embryonal pediatric brain tumor that almost always develops de novo and does not arise within, or evolve from, other brain tumor types. Although rhabdoid morphology can be seen in other tumor types, these are phenotypic mimics and, with only rare exceptions, do not manifest the INI-1 deletion at the 22q11.2 locus or the INI-1 nuclear protein loss that characterizes AT/RT. A few reports of AT/RT evolving from a low-grade ganglioglioma (GG) or pleomorphic xanthoastrocytoma have appeared. We present the case of a 6-year-old boy with a large right parietal mass whose tumor at initial presentation manifested 2 distinct components: GG with neoplastic neurons, low MIB-1 rate, and retention of INI-1 nuclear immunostaining (immunohistochemical) and, second, AT/RT with rhabdoid cells, polyphenotypic immunohistochemical expression, high MIB-1 rate, and loss of INI-1 nuclear expression. The 2 areas were separately assessed by fluorescence in situ hybridization for monosomy 22; monosomy 22 was identified in the AT/RT component but not in the GG areas. BRAF V600E mutation, a genetic abnormality seen in a significant percentage of pleomorphic xanthoastrocytomas and GGs, was assessed by polymerase chain reaction and identified in the tumor. Dual abnormalities of INI-1 loss and V600E BRAF mutation were identified in a cell culture line established from cerebrospinal fluid metastatic tumor cells. This cell line exhibited extremely rapid growth rate and rhabdoid morphology. Results suggest a postclonal modification in a subset of GG cells, with acquisition of INI-1 loss, confirming by biological methods what was previously suspected in rare reports of AT/RT evolving from other tumor types. PMID:22082607

Kleinschmidt-DeMasters, B K; Birks, Diane K; Aisner, Dara L; Hankinson, Todd C; Rosenblum, Marc K

2011-12-01

74

[Testicular tumor arising in intra-abdominal testis which was not detected at prior orchidopexy : a case report].  

PubMed

A 35-year-old man with an intra-abdominal testicular tumor arising from the right unresolved intraabdominal testis is reported. At 10 years old, left orchidopexy was successfully performed for bilateral undescended testes. However, the right testis was not detected during the operation, and it was diagnosed as vanishing testis. Twenty-five years later, he was referred to our hospital with the complaint of right lower abdominal pain. Computed tomography revealed huge pelvic tumors and bulky para-aortic lymph node swellings. Histopathologic examination of the needle biopsy specimen obtained from the pelvic tumor revealed seminomatous germ cell tumor. Taking the results with a tumor marker study into consideration, the patient was tentatively diagnosed with non-seminomatous germ cell tumor NSGCT (stage IIB) arising from the unresolved intra-abdominal testis or extragonadal germ cell tumor. He received 3 courses of bleomycin, etoposide, cisplatin (BEP), and 4 courses of VP-16, ifosfamide, cisplatin (VIP). After chemotherapy, we performed tumorectomy and retroperitoneal lymphadenectomy because tumor markers were normalized and 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET)-CT revealed normalization. We identified the pelvic tumor as an intra-abdominal testicular tumor arising from right unresolved intra-abdominal testis. Pathological examination revealed no residual tumor cells. There has been no recurrence 17 months after surgery. PMID:23633636

Iwamura, Hiromichi; Hatakeyama, Shingo; Fukushi, Ken; Sato, Tendo; Kojima, Yuta; Murasawa, Hiromi; Ishimura, Hirofumi; Yoneyama, Takahiro; Koie, Takuya; Kamimura, Noritaka; Morobashi, Satoko; Kijima, Hiroshi; Ohyama, Chikara

2013-03-01

75

Shah Gail (2009) HPC covers large number neoplasms arising one anatomic region included tumors mucosa upper aerodigestive tract including oral cavity Bronx larynx minuses. included tumors silvery glands thyroid soft tissue bone tumors skin cancers  

EPA Pesticide Factsheets

Did you mean: Shah Gail (2009) HPC covers large number neoplasms arising one anatomic region included tumors mucosa upper aerodigestive tract including oral cavity Bronx larynx minuses. included tumors silvery glands thyroid soft tissue bone tumors skin cancers ?

76

Accessory spleen arising from the gastric fundus mimicking gastrointestinal stromal tumor following splenectomy: A case report  

PubMed Central

The current case report presents an accessory spleen mimicking gastrointestinal stromal tumor (GIST) of the stomach in a patient who had undergone a splenectomy ~20 years previously. A 61-year-old male, who presented with upper abdominal discomfort lasting three months, underwent gastrointestinal endoscopy. Gastroscopy and endoscopic ultrasonography revealed a smooth, hemispherical mass of ~2 cm in diameter, with homogenous echogenicity originating from the gastric muscular layer. Abdominal contrast-enhanced computed tomography showed that the well-marginated ovoid mass was ~2.6×1.9 cm in size. The patient was diagnosed with GIST. Subsequent therapy consisted of partial gastrectomy. The pathological results indicated the mass contained splenic tissue, which confirmed it to be an accessory spleen. Changes in the postoperative platelet count were noted. The observations of this case study highlight that platelet count should be used as a routine indicator for monitoring accessory spleen arising from gastric fundus lesion.

WANG, GUANGYAO; CHEN, PING; ZONG, LIANG

2014-01-01

77

Impaired CXCL4 expression in tumor-associated macrophages (TAMs) of ovarian cancers arising in endometriosis.  

PubMed

Inflammatory cells play important roles in progression of solid neoplasms including ovarian cancers. Tumor-associated macrophages (TAMs) contribute to angiogenesis and immune suppression by modulating microenvironment. Ovarian cancer develops occasionally on the bases of endometriosis, a chronic inflammatory disease. We have recently demonstrated differential expressions of CXCR3 variants in endometriosis and ovarian cancers. In this study, we showed impaired CXCL4 expression in TAMs of ovarian cancers arising in endometriosis. The expressions of CXCL4 and its variant CXCL4L1 were investigated among normal ovaries (n = 26), endometriosis (n = 18) and endometriosis-associated ovarian cancers (EAOCs) composed of clear cell (n = 13) and endometrioid (n = 11) types. In addition, four cases of EAOCs that contained both benign and cancer lesions contiguously in single cysts were investigated in the study. Western blot and quantitative RT-PCR analyses revealed significant downregulation of CXCL4 and CXCL4L1 in EAOCs compared with those in endometriosis. In all EAOCs coexisting with endometriosis in the single cyst, the expression levels of CXCL4 and CXCL4L1 were significantly lower in cancer lesions than in corresponding endometriosis. Histopathological study revealed that CXCL4 was strongly expressed in CD68 (+) infiltrating macrophages of endometriosis. In microscopically transitional zone between endometriosis and EAOC, CD68 (+) macrophages often demonstrated CXCL4 (-) pattern. The majority of CD68 (+) TAMs in overt cancer lesions were negative for CXCL4. Collective data indicate that that CXCL4 insufficiency may be involved in specific inflammatory microenvironment of ovarian cancers arising in endometriosis. Suppression of CXCL4 in cancer lesions is likely to be attributable to TAMs in part. PMID:22555803

Furuya, Mitsuko; Tanaka, Reiko; Miyagi, Etsuko; Kami, Daisuke; Nagahama, Kiyotaka; Miyagi, Yohei; Nagashima, Yoji; Hirahara, Fumiki; Inayama, Yoshiaki; Aoki, Ichiro

2012-06-01

78

Ovarian mucinous tumors arising from mature cystic teratomas--a molecular genetic approach for understanding the cellular origin.  

PubMed

Mucinous tumors of the ovary are frequently associated with mature cystic teratomas, and it has been speculated that the mucinous tumors arise from teratoma components. The cellular origins of mature cystic teratomas are believed to be post-meiotic ovarian germ cells, and the analysis of microsatellite markers such as short tandem repeats is suitable for determining the cellular origin of tumors. In this study, we analyzed 3 ovarian mature cystic teratomas, all of which were associated with simultaneous ovarian mucinous tumors within the same ovary. Two of the 3 mucinous tumors were intestinal-type and the other was endocervical type. A laser capture microdissection technique was used to separate the epithelial component of the mucinous tumor, the components of the mature cystic teratoma, and control ovarian somatic tissue. Using short tandem repeat analysis based on 6 markers (D20S480, D6S2439, D6S1056, D9S1118, D4S2639, and D17S1290), we could distinguish the germ cell (homozygous) or somatic (heterozygous) origin of a given component in each sample. The epithelial components of the intestinal-type mucinous tumors in cases 1 and 2 were homozygous, and the epithelial component in case 3 (endocervical type) was heterozygous. All teratomatous components were homozygous, and the control components were heterozygous. In addition, we analyzed 3 mature cystic teratomas without mucinous tumors, and all 3 were homozygous in the tumor component. Our data suggest that the origin of mucinous tumors in the ovary may differ among histological subtypes, and intestinal-type mucinous tumors may arise from mature cystic teratomas, although endocervical-type mucinous tumors may not. PMID:24485845

Fujii, Kaho; Yamashita, Yoriko; Yamamoto, Toshimichi; Takahashi, Koji; Hashimoto, Katsunori; Miyata, Tomoko; Kawai, Kumi; Kikkawa, Fumitaka; Toyokuni, Shinya; Nagasaka, Tetsuro

2014-04-01

79

Primary carcinoid tumor of the ovary arising in a mature cystic teratoma: a case report.  

PubMed

Primary ovarian carcinoid tumors are rare entities, they may appear with other teratomatous components, and can be often being mistaken as part of mature cystic teratomas. Consistent with their rarity and low incidence, imaging clues that could have led to suspicion of this tumor are not well-documented. Herein, the authors present a rare case of primary ovarian carcinoid tumor in a mature cystic teratoma, who initially presented with complaints of abdominal distension for months. Contrast-enhanced computerized tomography (CT) demonstrated a multilobular mass with different density components including fat, soft tissue, and calcification materials, as well as rich vascular supply from the right ovarian vein. Serum tumor markers were within normal limits. Bilateral salpingo-oophorectomy was performed and the pathological diagnosis was mature cystic teratoma with coexisting primary ovarian carcinoid tumor, insular type. The patient has remained well with no residual disease for over one year of follow-up. PMID:24654475

Ting, W H; Hsiao, S M; Lin, H H; Wei, M C

2014-01-01

80

Human skin carcinoma arising from kidney transplant-derived tumor cells.  

PubMed

Tumor cells with donor genotype have been identified in human skin cancer after allogeneic transplantation; however, the donor contribution to the malignant epithelium has not been established. Kidney transplant recipients have an increased risk of invasive skin squamous cell carcinoma (SCC), which is associated with accumulation of the tumor suppressor p53 and TP53 mutations. In 21 skin SCCs from kidney transplant recipients, we systematically assessed p53 expression and donor/recipient origin in laser-microdissected p53+ tumor cells. In one patient, molecular analyses demonstrated that skin tumor cells had the donor genotype and harbored a TP53 mutation in codon 175. In a kidney graft biopsy performed 7 years before the skin SCC diagnosis, we found p53+ cells in the renal tubules. We identified the same TP53 mutation in these p53+ epithelial cells from the kidney transplant. These findings provide evidence for a donor epithelial cell contribution to the malignant skin epithelium in the recipient in the setting of allogeneic kidney transplantation. This finding has theoretical implications for cancer initiation and progression and clinical implications in the context of prolonged immunosuppression and longer survival of kidney transplant patients. PMID:23979160

Verneuil, Laurence; Varna, Mariana; Ratajczak, Philippe; Leboeuf, Christophe; Plassa, Louis-François; Elbouchtaoui, Morad; Schneider, Pierre; Sandid, Wissam; Lebbé, Celeste; Peraldi, Marie-Noelle; Sigaux, François; de Thé, Hugues; Janin, Anne

2013-09-01

81

Hypercalcemia associated with a malignant brenner tumor arising from a mature cystic teratoma.  

PubMed

A 60-year-old woman presented with abdominal pain and weight loss and was found to have serum calcium of 15.0 mg/dl. Serum parathyroid hormone-related peptide (PTHrP) returned elevated. Imaging suggested bilateral mature cystic teratomas. Her hypercalcemia was treated initially with intravenous saline, as well as intramuscular and subcutaneous calcitonin. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, and final pathology revealed malignant Brenner tumor in association with a mature cystic teratoma. Her postoperative PTHrP returned less than assay, and her total and ionized calcium fell below normal, requiring supplemental calcium and vitamin D. At follow-up one month after discharge, her calcium had normalized. We present the first reported case of hypercalcemia occurring in association with a malignant Brenner tumor. Malignancy-associated hypercalcemia occurs via four principal mechanisms: (1) tumor production of PTHrP; (2) osteolytic bone involvement by primary tumor or metastasis; (3) ectopic activation of vitamin D to 1,25-(OH)(2) vitamin D, and (4) ectopic production of parathyroid hormone. PTHrP-mediated hypercalcemia is the most common mechanism and was responsible in this case. In patients with paraneoplastic hypercalcemia who undergo surgical treatment, close monitoring and management of serum calcium is necessary both pre- and postoperatively. PMID:23185165

Honigberg, Michael C; Bradford, Leslie S; Prabhakar, Anand M; Hariri, Lida P; Goodman, Annekathryn

2012-09-01

82

Human skin carcinoma arising from kidney transplant-derived tumor cells  

PubMed Central

Tumor cells with donor genotype have been identified in human skin cancer after allogeneic transplantation; however, the donor contribution to the malignant epithelium has not been established. Kidney transplant recipients have an increased risk of invasive skin squamous cell carcinoma (SCC), which is associated with accumulation of the tumor suppressor p53 and TP53 mutations. In 21 skin SCCs from kidney transplant recipients, we systematically assessed p53 expression and donor/recipient origin in laser-microdissected p53+ tumor cells. In one patient, molecular analyses demonstrated that skin tumor cells had the donor genotype and harbored a TP53 mutation in codon 175. In a kidney graft biopsy performed 7 years before the skin SCC diagnosis, we found p53+ cells in the renal tubules. We identified the same TP53 mutation in these p53+ epithelial cells from the kidney transplant. These findings provide evidence for a donor epithelial cell contribution to the malignant skin epithelium in the recipient in the setting of allogeneic kidney transplantation. This finding has theoretical implications for cancer initiation and progression and clinical implications in the context of prolonged immunosuppression and longer survival of kidney transplant patients.

Verneuil, Laurence; Varna, Mariana; Ratajczak, Philippe; Leboeuf, Christophe; Plassa, Louis-Francois; Elbouchtaoui, Morad; Schneider, Pierre; Sandid, Wissam; Lebbe, Celeste; Peraldi, Marie-Noelle; Sigaux, Francois; de The, Hugues; Janin, Anne

2013-01-01

83

Sac phosphatase domain proteins.  

PubMed Central

Advances in our understanding of the roles of phosphatidylinositol phosphates in controlling cellular functions such as endocytosis, exocytosis and the actin cytoskeleton have included new insights into the phosphatases that are responsible for the interconversion of these lipids. One of these is an entirely novel class of phosphatase domain found in a number of well characterized proteins. Proteins containing this Sac phosphatase domain include the yeast Saccharomyces cerevisiae proteins Sac1p and Fig4p. The Sac phosphatase domain is also found within the mammalian phosphoinositide 5-phosphatase synaptojanin and the yeast synaptojanin homologues Inp51p, Inp52p and Inp53p. These proteins therefore contain both Sac phosphatase and 5-phosphatase domains. This review describes the Sac phosphatase domain-containing proteins and their actions, with particular reference to the genetic and biochemical insights provided by study of the yeast Saccharomyces cerevisiae.

Hughes, W E; Cooke, F T; Parker, P J

2000-01-01

84

A Rare Case of Endolymphatic Sac Tumour: Clinicopathologic Study and Surgical Management  

PubMed Central

Objective. Endolymphatic sac tumor (ELST) is a rare neoplasm arising from the intrapetrous portion of the endolymphatic sac, either isolated or in association with the von Hippel-Lindau disease. We report a sporadic case of ELST with an overview of the literature and a discussion of clinic-radiological, histopathologic, and surgical findings. Case Report. A young woman presented with a progressive hearing loss in the left ear. Otoscopy showed a reddish, bleeding hypotympanic mass. CT demonstrated an expansile lytic mastoid lesion extending to the middle ear, with bone erosion. MRI confirmed a lesion of increased signal on T1-weighted sequences. The patient underwent a canal wall-down tympanoplasty with complete removal of the tumor. Histopathology was consistent with a papillary ELST. Immunohistochemistry was positive for cytokeratin and chromogranin A. Conclusion. This paper highlights the rarity of ELST, the need for an accurate neuroradiological and immunohistochemical study at the early stages, and the timeliness of surgical treatment.

Ferri, Emanuele; Amadori, Maurizio; Armato, Enrico; Pavon, Ida

2014-01-01

85

Cellular schwannoma arising from the gastric wall misdiagnosed as a gastric stromal tumor: A case report  

PubMed Central

Cellular schwannomas have been previously described at almost every anatomic location of the human body, but reports in the gastric wall are rare. The current study presents a rare case of cellular schwannoma originating from the gastric wall. Computed tomography revealed a 5.6×5.3×4.0-cm3 solid mass located in the posterior wall of the stomach. Open laparotomy confirmed its mesenchymal origin. Microscopically, the tissue was composed of spindle-shaped and fascicularly-arranged cells, but mitotic figures were rare. Immunohistochemical staining showed that the tumor was negative for cluster of differentiation (CD)117, CD34, smooth muscle actin and desmin, but positive for S-100 and Ki67. The patient presented no evidence of recurrence and metastasis during follow-up. Gastric cellular schwannomas may be diagnosed by clinical characteristics, histological observations and immunohistochemical markers.

WANG, GUANGYAO; CHEN, PING; ZONG, LIANG; SHI, LEI; ZHAO, WEI

2014-01-01

86

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.  

PubMed Central

GGA to GAA mutations in the 12th codon of the Hras gene are frequently observed in rat mammary tumors induced by N-nitroso-N-methylurea (NMU). We developed an assay to measure point mutations present in tissues at a frequency of 10(-5) and have now applied this assay to measure the specific G to A transition of the Hras gene in rat mammary epithelium. We find that (i) 70% of untreated rats contain detectable levels of Hras mutants; (ii) these mutants are clustered within the gland as sectors in a manner consistent with their origin as a mutation arising during early organ development; and (iii) treatment with a carcinogenic dose of NMU did not result in a significant increase in the number of such mutants, the fraction of organ sectors with mutant cells, or the fraction of animals containing detectable levels of ras mutants. We conclude that the NMU-induced mammary tumors carrying the G to A transition at the 12th codon of the Hras gene arose from preexisting ras mutants and that an independent effect of NMU was directly or indirectly responsible for tumor formation. Images

Cha, R S; Thilly, W G; Zarbl, H

1994-01-01

87

Recent developments in SAC2000.  

National Technical Information Service (NTIS)

Before discussing recent developments in SAC2000, I will summarize what SAC2000 is/does. SAC2000 is the rebirth and evolution of Lawrence Livermore National Laboratory's (LLNL's) Seismic Analysis Code (SAC) developed during the 1980's for a variety of geo...

P. Goldstein D. Dodge M. Firpo

1997-01-01

88

The histogenic origin of melanoma arising in respiratory epithelium of a teratomatous germ cell tumor of the mediastinum: an enigma unraveled from an unlikely source.  

PubMed

Mixed germ cell tumors are rare neoplasms that are known to occur in the anterior mediastinum. Characterized by two or more types of germ cell components, these tumors comprise upwards of 25% of mediastinal germ cell tumors. Even rarer are those harboring somatic-type malignancies such as carcinoma, sarcoma, and hematopoietic malignancies. To date, however, there are no known cases of melanoma arising in a malignant mixed germ cell tumor of the anterior mediastinum. We describe the first case of malignant melanoma with spindle and epithelioid components arising from respiratory epithelium in a mediastinal malignant mixed germ cell tumor of a 32-year-old male. In addition, we also provide evidence supporting the theory of neuroendocrine cells as the origin of melanoma arising in the respiratory epithelium. This case emphasizes the need to carefully evaluate all germ cell tumors, not only for a myriad of benign embryological components, but also for malignancies arising in these components, as they might change the prognosis and patient's course of treatment. This microscopic approach should bring to light the diversity of mixed germ cell tumors in addition to somatic malignancies with corresponding biologic potentials. PMID:23119117

McNab, Patricia; Quigley, Brian; Mendoza, Tania; Hakam, Ardeshir; Khalil, Farah; Fishman, Mayer; Altiok, Soner

2012-01-01

89

The histogenic origin of melanoma arising in respiratory epithelium of a teratomatous germ cell tumor of the mediastinum: an enigma unraveled from an unlikely source  

PubMed Central

Mixed germ cell tumors are rare neoplasms that are known to occur in the anterior mediastinum. Characterized by two or more types of germ cell components, these tumors comprise upwards of 25% of mediastinal germ cell tumors. Even rarer are those harboring somatic-type malignancies such as carcinoma, sarcoma, and hematopoietic malignancies. To date, however, there are no known cases of melanoma arising in a malignant mixed germ cell tumor of the anterior mediastinum. We describe the first case of malignant melanoma with spindle and epithelioid components arising from respiratory epithelium in a mediastinal malignant mixed germ cell tumor of a 32-year-old male. In addition, we also provide evidence supporting the theory of neuroendocrine cells as the origin of melanoma arising in the respiratory epithelium. This case emphasizes the need to carefully evaluate all germ cell tumors, not only for a myriad of benign embryological components, but also for malignancies arising in these components, as they might change the prognosis and patient’s course of treatment. This microscopic approach should bring to light the diversity of mixed germ cell tumors in addition to somatic malignancies with corresponding biologic potentials.

McNab?, Patricia; Quigley, Brian; Mendoza, Tania; Hakam, Ardeshir; Khalil, Farah; Fishman, Mayer; Altiok, Soner

2012-01-01

90

Diagnosis and management of female adnexal tumor of probable Wolffian origin (FATWO) arising from ovary: a case report  

PubMed Central

Female adnexal tumor of probable Wolffian origin (FATWO) is a rare neoplasm which is usually considered as benign, although in some cases metastasis or recurrences have been reported even after a long interval following the initial diagnosis. Preoperative diagnosis of FATWO is very difficult because of the rarity of the disease and the limited literature available. In this case report, we present a case of FATWO arising from the ovary and review the literature based on the clinical characteristics and management of this rare condition. A 51- year- old postmenopausal woman was referred to our clinic for evaluation of an adnexal mass. After diagnostic evaluation, the patient underwent explorative laparotomy. Intra-operatively, a solid- cystic mass was found in the right ovary, the rest of the abdomen and the pelvis were normal. The ovarian mass was removed and examined with frozen-section (FS). When the frozen section proved negative for malignancy, total abdominal hysterectomy and bilateral adnexectomy were performed. The anatomic study revealed a well-capsulated mass which was 3.5×1.5 cm in diameter. Based on pathological and immunohistochemical results, the final diagnosis was concluded to be FATWO. Adjuvant therapy was not administered. Te patient was followed up after discharge from the hospital. One year after surgery she was asymptomatic. No evidences of recurrence were observed throughout this period. Although FATWOs are rare tumors, they should be kept in mind in women with an abdominal mass. They can present diagnostic difficulties and the diagnosis is based on the exclusion of other neoplasms. FATWO has malignant potential, after the initial surgical treatment patients should be appropriately followed up for possible recurrence and metastasis.

Turkcapar, Ayse Figen; Seckin, Berna; Gungor, Tayfun; Sirvan, Levent; Mollamahmutoglu, Leyla

2013-01-01

91

Diagnosis and management of female adnexal tumor of probable Wolffian origin (FATWO) arising from ovary: a case report.  

PubMed

Female adnexal tumor of probable Wolffian origin (FATWO) is a rare neoplasm which is usually considered as benign, although in some cases metastasis or recurrences have been reported even after a long interval following the initial diagnosis. Preoperative diagnosis of FATWO is very difficult because of the rarity of the disease and the limited literature available. In this case report, we present a case of FATWO arising from the ovary and review the literature based on the clinical characteristics and management of this rare condition. A 51- year- old postmenopausal woman was referred to our clinic for evaluation of an adnexal mass. After diagnostic evaluation, the patient underwent explorative laparotomy. Intra-operatively, a solid- cystic mass was found in the right ovary, the rest of the abdomen and the pelvis were normal. The ovarian mass was removed and examined with frozen-section (FS). When the frozen section proved negative for malignancy, total abdominal hysterectomy and bilateral adnexectomy were performed. The anatomic study revealed a well-capsulated mass which was 3.5×1.5 cm in diameter. Based on pathological and immunohistochemical results, the final diagnosis was concluded to be FATWO. Adjuvant therapy was not administered. Te patient was followed up after discharge from the hospital. One year after surgery she was asymptomatic. No evidences of recurrence were observed throughout this period. Although FATWOs are rare tumors, they should be kept in mind in women with an abdominal mass. They can present diagnostic difficulties and the diagnosis is based on the exclusion of other neoplasms. FATWO has malignant potential, after the initial surgical treatment patients should be appropriately followed up for possible recurrence and metastasis. PMID:24592074

Türkçapar, Ayse Figen; Seçkin, Berna; Güngör, Tayfun; Sirvan, Levent; Mollamahmuto?lu, Leyla

2013-01-01

92

Metastases to Hernial Sac Detected on 18F-FDG PET/CT.  

PubMed

The presence of primary or metastatic cancer within a hernial sac is uncommon. Based on the anatomical relation of the tumor to the sac, malignant tumors within hernia sac are classified into 3 groups; intrasaccular, saccular, and extrasaccular. We present F-FDG PET/CT images of 2 cases of hernia sac metastasis, one from non-small cell lung cancer and another from infiltrating ductal breast carcinoma. F-FDG PET/CT was useful in these cases for detection of the metastatic lesion within hernial sac and thus in assessment of total disease burden. PMID:24896767

Jain, Sachin; Karunanithi, Sellam; Sharma, Punit; Singla, Suhas; Kumar, Rakesh

2014-07-01

93

Giant dacryocystomucopyocele in an adult: a review of lacrimal sac enlargements with clinical and histopathologic differential diagnoses.  

PubMed

Dacryocystocele is an umbrella term that refers to any diffuse, centrifugal enlargement of the lacrimal sac that results from combined proximal and distal obstructions in the tear drainage system. In adults, the presence of mucus in the cyst's contents leads to the modified term of dacryocystomucocele. If infection supervenes, which almost always occurs in protracted cases and adds the clinical dimension of a dacryocystitis, then a dacryocystomucopyocele is created. Dacryocystocele and its congeners are much rarer in adults than in children. We describe a 95-year-old woman with an acquired, enormous dacryocystomucopyocele, larger than any previously reported, that developed over 25 years and produced globe displacement with an associated conspicuous enlargement of the nasolacrimal duct. The aspirated sac fluid was mucopurulent and harbored low-virulence bacterial organisms of the Prevotella and Petosteptococcus species. In infants, dacryocystoceles are transitory as the result of spontaneously reversible factors. In adults, secondary proximal irreversible fibrotic strictures or bony changes around the nasolacrimal duct typically arise from chronic inflammation or low grade infection. Other possible causations of duct obstruction, in addition to florid mucosal edema, include encroachment on the duct by enlarged contiguous ethmoid air cells; a sinus mucocele or sinusitis; idiopathic, post-traumatic or dysplastic bony remodeling of the wall of the duct; and a neoplasm-all of which require some form of surgical intervention, typically dacryocystorhinostomy. The differential diagnosis of medial canthal swellings centered on the lacrimal sac spans malformations, diverticula, dermoid/epidermoid cysts, sac inflammations/infections causing swelling without generalized sac enlargement, encephaloceles and primary epithelial tumors, as well as extrinsic tumors impinging on the sac. PMID:22784678

Perry, Lynn J P; Jakobiec, Frederick A; Zakka, Fouad R; Rubin, Peter A D

2012-09-01

94

Epithelioid Malignant Peripheral Nerve Sheath Tumor Arising in a Schwannoma, in a Patient with "Neuroblastoma-like" Schwannomatosis and a Novel Germline SMARCB1 mutation  

PubMed Central

Epithelioid malignant peripheral nerve sheath tumors arising in pre-existing schwannomas are extremely rare. We report an unusual example occurring in a patient with multiple schwannomas (schwannomatosis), all but one of which showed “neuroblastoma-like” histology. By immunohistochemistry, both the epithelioid malignant peripheral nerve sheath tumor and the schwannomas showed a complete loss of the Smarcb1 protein. Subsequent genetic evaluation revealed the presence of a novel germline mutation in the SMARCB1/INI1 gene in the patient and three of her children, two of whom were diagnosed with atypical teratoid/rhabdoid tumors of the brain.

Carter, Jodi M.; O'Hara, Carolyn; Dundas, George; Gilchrist, Dawna; Collins, Mark S.; Eaton, Katherine; Judkins, Alexander R.; Biegel, Jaclyn A.; Folpe, Andrew L.

2011-01-01

95

Endoscopic Ultrasound-Assisted Tunnel-Type Endoscopic Submucosal Dissection for the Treatment of Esophageal Tumors Arising in the Muscularis Propria (with video)  

PubMed Central

Objective: Esophageal tumors arising in the muscularis propria are difficult to be resected endoscopically using standard electro-surgical techniques, even the endoscopic submucosal dissection (ESD) technique appeared recently. Our purpose is to investigate the efficacy of endoscopic ultrasound (EUS)-assisted tunnel-type ESD for resection of these tumors. Methods: A total of 17 patients were included in this study. A standard endoscope was used. The submucosal tunnel was created with the triangle knife according to the standard ESD technique, about 5 cm proximal to the lesion. EUS was performed within the tunnel to detect the tumor, and then the tumor was separated both from the submucosal and the muscle layers. After the tumor was removed, several clips were used to close the mucosal defect. EUS was performed to evaluate the healing quality 1 week after the procedure. Result: In all the cases, the tumors were completely resected. Mean tumor size was 24.2 mm (12-50 mm) in diameter. The histo-logical diagnoses were leiomyoma (16/17) and gastrointestinal stromal tumor (GIST, 1/17). Subcutaneous emphysema was found in 2 patients after the procedure, but disappeared by the third day. No patients sustained perforation or developed significant hem-orrhage, and there were no other immediate severe complications after the procedure. The healing quality was satisfying in 16/17 patients evaluated by EUS 1 week after the procedure. No recurrence has been found during follow-up (mean 7 months, range 3-13 months). Conclusion: EUS-assisted tunnel-type ESD is effective and safe in treatment of esophageal tumors arising in the muscularis pro-pria.

Ge, Nan; Sun, Siyu; Wang, Sheng; Liu, Xiang; Wang, Guoxin; Guo, Jintao

2013-01-01

96

Exceptionally large solitary fibrous tumor arising from the cheek: an immunohistochemical and ultrastructural study with a review of the literature.  

PubMed

Solitary fibrous tumor (SFT) is a rare mass-forming soft tissue tumor that occurs most commonly in the pleura, but has been described in various extrathoracic sites. Extrapleural manifestation of SFT, particularly in the head and neck region, is rare. The most common extrapleural site is the oral cavity; these tumors have also been described in the orbit, nasopharynx, paranasal sinuses, salivary glands, and larynx. We report an extremely rare case of a SFT in the subcutaneous region of the cheek. This tumor in the left cheek was a large firm mass, approximately 8.5 cm × 6 cm in size and was successfully treated by surgical resection. Immunohistochemistry revealed reactivity for vimentin, CD34, and bcl-2, but no staining for cytokeratin, epithelial membrane antigen, S-100, desmin, caldesmon, actin, ?-smooth muscle actin, CD117, and CD99. Immunohistochemical study is the key to establish a definitive diagnosis of SFT, and ultrastructural study is also useful for making an accurate diagnosis. The patient recovered uneventfully without evidence of tumor recurrence 2 years after surgery. PMID:24221815

Satomi, Takafumi; Hasegawa, On; Abukawa, Harutsugu; Kohno, Michihide; Enomoto, Ai; Chikazu, Daichi; Matsubayashi, Jun; Nagao, Toshitaka

2014-06-01

97

[Carcinoma of the lacrimal sac: a clinicopathologic case study].  

PubMed

A case of undifferentiated carcinoma of the right lacrimal sac is reported in an 85-year-old woman who had already presented three previous carcinomas (uterine cervix, rectum, and breast). After a 1-year history of chronic dacryocystitis, she was admitted in January 2008 because of a painful and inflammatory swelling in the medial right lower eyelid. Imaging techniques showed an infiltrative mass in the lacrimal sac area and surgical biopsy disclosed undifferentiated carcinoma. The patient underwent orbital exenteration and the histopathological study confirmed the diagnosis. During 6 months of follow-up, no local recurrence was detected, but a thoracic CT scan revealed a pulmonary nodule that was probably metastatic. Making an early diagnosis of a lacrimal sac tumor is difficult and it should be considered in the differential diagnosis of chronic dacryocystitis. In these cases, more extensive research with lacrimal sac biopsy should be conducted. PMID:19515455

Pereira, D; Meyer, A; Slama, M; Hugol, D; D'Hermies, F

2009-06-01

98

Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases  

PubMed Central

Introduction Breast carcinoma is the most common cancer in women, but its incidence is not increased in Lynch syndrome (LS) and studies on DNA mismatch repair deficiency (MMR) in LS-associated breast cancers have arrived at conflicting results. This study aimed to settle the question as to whether breast carcinoma belongs to the LS tumor spectrum. Methods MMR status and epigenetic profiles were determined for all available breast carcinomas identified among 200 LS families from a nation-wide registry (23 tumors from mutation carriers and 18 from non-carriers). Sporadic breast carcinomas (n = 49) and other cancers (n = 105) from MMR gene mutation carriers were studied for comparison. Results The proportion of breast carcinomas that were MMR-deficient based on absent MMR protein, presence of microsatellite instability, or both was significantly (P = 0.00016) higher among breast carcinomas from mutation carriers (13/20, 65%) compared to non-carriers (0/14, 0%). While the average age at breast carcinoma diagnosis was similar in carriers (56 years) and non-carriers (54 years), it was lower for MMR-deficient versus proficient tumors in mutation carriers (53 years versus 61 years, P = 0.027). Among mutation carriers, absent MMR protein was less frequent in breast carcinoma (65%) than in any of seven other tumor types studied (75% to 100%). Tumor suppressor promoter methylation patterns were organ-specific and similar between breast carcinomas from mutation carriers and non-carriers. Conclusions Breast carcinoma from MMR gene mutation carriers resembles common breast carcinoma in many respects (for example, general clinicopathological and epigenetic profiles). MMR status makes a distinction: over half are MMR-deficient typical of LS spectrum tumors, while the remaining subset which is MMR-proficient may develop differently. The results are important for appropriate surveillance in mutation carriers and may be relevant for LS diagnosis in selected cases.

2012-01-01

99

Solitary Fibrous Tumor arising in extremity: A report of two cases with 201Thallium Scintigraphic and PET findings  

Microsoft Academic Search

Summary We report two cases of solitary fibrous tumor affecting the extremities, with 201-thallium scintigraphic and positron emission tomographic appearance. Preoperative magnetic resonance imaging features in both cases were non-specific. Both patients underwent a wide excision. Histologically, case 1 showed spindle cells growing in \\

Tomoaki Fukui; Yoji Kawaguchi; Teruya Kawamoto; Toshiaki Hitora; Tetsuji Yamamoto; Toshihiro Akisue; Yoshio Kushida; Reiji Haba

100

Recent developments in SAC2000  

SciTech Connect

Before discussing recent developments in SAC2000, I will summarize what SAC2000 is/does. SAC2000 is the rebirth and evolution of Lawrence Livermore National Laboratory`s (LLNL`s) Seismic Analysis Code (SAC) developed during the 1980`s for a variety of geophysical applications. Primary funding for the development of SAC2000 has been through the LLNL as part of the Department of Energy`s (DOE`s) CTBT R&D program. The primary development goals for SAC2000 have been to meet the seismic signal processing and analysis needs of the DOE CTBT R&D teams and the rest of the CTBT R&D community. SAC2000`s strengths include its ability to process a diverse range of data types, its extensive, well documented signal processing capabilities (both on-line and on the web at http://www-ep.es.llnl.gov/tvp/sac.html), its macro language, and its ability to do both branch and interactive processing. Its extensive usage (over 200 institutions worldwide) had also made it much easier for researchers to develop collaborative research projects. SAC2000`s extensive signal processing capabilities include: data inspection, signal correction, and quality control, unary and binary data operations, travel-time analysis, spectral analysis including high-resolution spectral estimation, spectrograms and binary sonograms, and array and three-component analysis. Recent development in SAC2000 include: enhanced compatibility with the CSS3.0 database schema, complete compatibility with the widely used SEED data format instrument responses, map making capabilities via an interface to GMT, a new three component polarization and phase identification tool, an external interface that allows users to define their own commands, and an interface to MATLAB that allows the user to use MATLAB commands and scripts on SAC data from within SAC2000. We have also implemented a number of commands to enhance user efficiency and numerous improvements and enhancements to many individual SAC commands. Current development in SAC2000 are motivated by the need for easy and efficient access to, and processing and interpretation of large amounts of data. We are also driven by the need to communicate results from SAC2000 to our database and other programs. Based on these needs, we have begun developing a new data structure for SAC 2000. This new structure will completely compatible with the standard SAC format but will also allow us to access, modify, and output all the information in CSS3.0 based oracle databases or CSS3.0 flat files. Given the variety of data types that are currently possible in SAC2000 and other programs, and the likelihood that additional data types or parameters will be needed in the future, we designing SAC2000`s new format to be easily extendible and anticipate incorporation of significant extensions to the CSS3.0 schema.

Goldstein, P.; Dodge, D.; Firpo, M

1997-07-01

101

Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors  

ClinicalTrials.gov

Childhood Extracranial Germ Cell Tumor; Childhood Extragonadal Germ Cell Tumor; Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Yolk Sac Tumor; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Ovarian Germ Cell Tumor; Testicular Choriocarcinoma; Testicular Choriocarcinoma and Embryonal Carcinoma; Testicular Choriocarcinoma and Yolk Sac Tumor; Testicular Embryonal Carcinoma; Testicular Embryonal Carcinoma and Yolk Sac Tumor; Testicular Yolk Sac Tumor

2014-03-18

102

Cancer Resistance in Transgenic Mice Expressing the SAC Module of Par4  

Microsoft Academic Search

Prostate apoptosis response-4 (Par-4) is a tumor-suppressor protein that induces apoptosis in cancer cells, but not in normal\\/immortalized cells. The cancer-specific proapop- totic action of Par-4 is encoded in its centrally located SAC domain. We report here the characterization of a novel mouse model with ubiquitous expression of the SAC domain. Although SAC transgenic mice displayed normal develop- ment and

Yanming Zhao; Ravshan Burikhanov; Shirley Qiu; Subodh M. Lele; C. Darrell Jennings; Subbarao Bondada; Vivek M. Rangnekar

2007-01-01

103

Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke-L?wenstein tumor): a case report and review of the literature  

PubMed Central

Introduction Verrucous carcinoma of the external genitalia and perianal region is a rare variant of well-differentiated squamous cell carcinoma. It has been reported to have limited metastatic potential. Case presentation We report the case of a 54 year-old Moroccan man who presented with locally advanced giant condyloma acuminatum (Buschke–Löwenstein tumor) after prolonged intervals of neglect (approximately 10 years). The disease covered his suprapubic, external genitalia and perianal region. It was locally aggressive with extensive tissue destruction. After a biopsy of the lesion, the diagnosis of verrucous carcinoma was confirmed. He initially received chemoradiotherapy, followed by extensive local excision, but he developed septic shock and died a few days later. Conclusions The purpose of this case report is to present a case of verrucous carcinoma arising in an extensive giant condyloma acuminatum (Buschke–Löwenstein tumor) and discuss the literature on its diagnosis and management.

2013-01-01

104

Primary malignant melanoma of the lacrimal sac: a case report.  

PubMed

Malignant melanoma of the lacrimal sac is very rare and primary malignant melanoma is extremely rare. It is usually diagnosed at an advanced stage after excision or biopsy of a tumor. We treated a patient with tearing and bloody discharge from the left eye. We performed a dacryocystectomy with the suspicion of a chronic dacryocystitis. However, the pathological findings and the immunohistochemical studies showed a malignant melanoma of the lacrimal sac. The patient underwent postoperative irradiation therapy. Follow up two months after surgery revealed no evidence of recurrence. Early diagnosis is very important for prognosis in patients with malignant melanoma of the lacrimal sac. Because this tumor often presents with symptoms similar to dacryocystitis and may masquerade as a chronic dacryocystitis, it can be difficult to make an early diagnosis. PMID:17249508

Nam, Ji Hyung; Kim, Seung Min; Choi, Jae Hyeuk; Lee, Yong Kuk; Baek, Jin Ho; Jang, Tae Jung; Park, Keon Uk

2006-12-01

105

Primary malignant melanoma of the lacrimal sac: A case report  

PubMed Central

Malignant melanoma of the lacrimal sac is very rare and primary malignant melanoma is extremely rare. It is usually diagnosed at an advanced stage after excision or biopsy of a tumor. We treated a patient with tearing and bloody discharge from the left eye. We performed a dacryocystectomy with the suspicion of a chronic dacryocystitis. However, the pathological findings and the immunohistochemical studies showed a malignant melanoma of the lacrimal sac. The patient underwent postoperative irradiation therapy. Follow up two months after surgery revealed no evidence of recurrence. Early diagnosis is very important for prognosis in patients with malignant melanoma of the lacrimal sac. Because this tumor often presents with symptoms similar to dacryocystitis and may masquerade as a chronic dacryocystitis, it can be difficult to make an early diagnosis.

Nam, Ji Hyung; Kim, Seung Min; Choi, Jae Hyeuk; Lee, Yong Kuk; Baek, Jin Ho; Jang, Tae Jung

2006-01-01

106

Pituitary carcinoma with endolymphatic sac metastasis.  

PubMed

Pituitary carcinoma is characterized by the presence of a metastatic lesion(s) in a location non-contiguous with the original pituitary tumor. The mechanism(s) of malignant transformation are not known. A 15 year-old male was diagnosed in 1982 with a pituitary macroadenoma and acromegaly (random GH 67 ng/ml and no suppression by oral glucose). His prolactin was normal between 18 and 23 ng/ml. Transcranial resection in July 1983 was followed by radiation therapy. The tumor was immunopositive for GH and prolactin. The proliferation MIB-1 index was 0-1 %. With aqueous Octreotide 100 mcg 4× daily both GH and IGF-1 became normal. The patient was lost to follow-up and was treated by his local physician. In 2001, his IGF-1 level was 1271 ng/ml, and his random GH was 1.8-2.4 ng/ml by ILMA despite progressive increase in the dose of Sandostatin LAR to 140 mg/month in divided doses. Prolactin remained normal or minimally increased between 15 and 25 ng/ml. In 2009 he was diagnosed with the tumor in the location of left endolymphatic sac. Histological examination showed low grade pituitary carcinoma strongly immunopositive for prolactin but negative for GH. MIB-1 antibody labeled 0-5 % cells. In 2012 endoscopic resection of the pituitary tumor remnant was attempted. Immunohistochemical stains were strongly immunopositive for both prolactin and GH, similar to his original pituitary tumor. The MIB-1 proliferation index was low from 0 to 1 %. To our knowledge this is the first case of pituitary carcinoma in the endolymphatic sac region. The dichotomy between the cell population of the pituitary lesion (GH/prolactin producing) and the metastasis (purely prolactin-producing) may suggest that the metastatic pituitary lesion derived from a clone distinct from the original one. PMID:23645293

Balili, Irida; Sullivan, Steven; McKeever, Paul; Barkan, Ariel

2014-06-01

107

Project ARISE  

NSDL National Science Digital Library

Project ARISE (American Renaissance in Science Education) is an initiative to restructure the high-school science curriculum by changing the order in which courses are traditionally taught--placing physics first, followed by chemistry, then biology (instead of biology-chemistry-physics). This approach to the science curriculum is a collaborative effort that brings teachers and scientists together in the educational process. Site materials include a brief overview of the program and a video presentation on the state of science education in the United States. There are also curriculum materials for each subject: sets of units on biology and physics, and tutorials and lab simulations for chemistry.

Lederman, Leon

2006-02-13

108

Cancer resistance in transgenic mice expressing the SAC module of Par-4.  

PubMed

Prostate apoptosis response-4 (Par-4) is a tumor-suppressor protein that induces apoptosis in cancer cells, but not in normal/immortalized cells. The cancer-specific proapoptotic action of Par-4 is encoded in its centrally located SAC domain. We report here the characterization of a novel mouse model with ubiquitous expression of the SAC domain. Although SAC transgenic mice displayed normal development and life span, they were resistant to the growth of spontaneous, as well as oncogene-induced, autochthonous tumors. Resistance to tumorigenesis was linked to inhibition of nuclear factor-kappaB activity and induction of apoptosis by the SAC domain. Collectively, our findings provide genetic evidence that the SAC domain of Par-4 confers cancer resistance in transgenic mice without compromising normal viability or aging, and may have therapeutic significance. PMID:17909035

Zhao, Yanming; Burikhanov, Ravshan; Qiu, Shirley; Lele, Subodh M; Jennings, C Darrell; Bondada, Subbarao; Spear, Brett; Rangnekar, Vivek M

2007-10-01

109

A Garlic Derivative, S-allylcysteine (SAC), Suppresses Proliferation and Metastasis of Hepatocellular Carcinoma  

PubMed Central

Background Hepatocellular carcinoma (HCC) is highly malignant and metastatic. Currently, there is no effective chemotherapy for patients with advanced HCC leading to an urgent need to seek for novel therapeutic options. We aimed to investigate the effect of a garlic derivative, S-allylcysteine (SAC), on the proliferation and metastasis of HCC. Methodology/Principal Findings A series of in vitro experiments including MTT, colony-forming, wound-healing, invasion, apoptosis and cell cycle assays were performed to examine the anti-proliferative and anti-metastatic effects of SAC on a metastatic HCC cell line MHCC97L. The therapeutic values of SAC single and combined with cisplatin treatments were examined in an in vivo orthotopic xenograft liver tumor model. The result showed that the proliferation rate and colony-forming abilities of MHCC97L cells were suppressed by SAC together with significant suppression of the expressions of proliferation markers, Ki-67 and proliferating cell nuclear antigen (PCNA). Moreover, SAC hindered the migration and invasion of MHCC97L cells corresponding with up-regulation of E-cadherin and down-regulation of VEGF. Furthermore, SAC significantly induced apoptosis and necrosis of MHCC97L cells through suppressing Bcl-xL and Bcl-2 as well as activating caspase-3 and caspase-9. In addition, SAC could significantly induce the S phase arrest of MHCC97L cells together with down-regulation of cdc25c, cdc2 and cyclin B1. In vivo xenograft liver tumor model demonstrated that SAC single or combined with cisplatin treatment inhibited the progression and metastasis of HCC tumor. Conclusions/Significance Our data demonstrate the anti-proliferative and anti-metastatic effects of SAC on HCC cells and suggest that SAC may be a potential therapeutic agent for the treatment of HCC patients.

Cheng, Qiao; Geng, Wei; Ling, Chang Chun; Li, Chang Xian; Liu, Xiao Bing; Ma, Yuen Yuen; Lo, Chung Mau; Poon, Ronnie T. P.; Fan, Sheung Tat; Man, Kwan

2012-01-01

110

The esterification of cholesterol in the yolk sac membrane of the chick embryo  

Microsoft Academic Search

The uptake of lipid from the yolk by the yolk sac membrane of the chick embryo is accompanied by the rapid esterification\\u000a of a large proportion of the yolk cholesterol. This could arise from enhanced acyl-CoA:cholesterol acyltransferase (ACAT)\\u000a activity and\\/or inhibition of cholesteryl ester hydrolase (CEH) activity. The activity of ACAT was therefore measured in microsomes\\u000a obtained from yolk sac

J. H. Shand; D. W. West; R. J. McCartney; R. C. Noble; B. K. Speake

1993-01-01

111

Primary diffuse large B-cell lymphoma of the lacrimal sac simulating chronic dacryocystitis.  

PubMed

Primary diffuse large B-cell lymphoma of the lacrimal sac is rare. Herein we report a 55-year-old female presented with epiphora in the right eye. Distention of the lacrimal sac secondary to nasolacrimal duct obstruction was observed. She was scheduled for external dacryocystorinostomy for the next month. When she came for surgery, a growing mass was recognised over the lacrimal sac region. On computer tomography scan, a subdermal mass causing nasal bone destruction was detected. Excisional biopsy of the mass was performed. Histopathologic and immunohistochemical evaluations revealed primary diffuse large B-cell non-Hodgkin lymphoma of the lacrimal sac. She was treated with cyclophospamide, vincristine, adriablastine and prednisone for eight courses combined with rituximab for 6 months. During a follow-up period of 25 months, patient is stable with no systemic disease. Although rare, lacrimal sac tumors can mimic dacryocystitis and must be considered in differential diagnosis. In suspicious cases incisional biopsy is recommended. PMID:21353409

Palamar, Melis; Midilli, Rasit; Ozsan, Nazan; Egrilmez, Sait; Sahin, Fahri; Yagci, Ayse

2011-10-01

112

IgG4-Related Lacrimal Sac Diverticulitis.  

PubMed

Abstract IgG4-related disease is characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. We herein report a case of lacrimal sac diverticulitis with marked IgG4-positive plasma cell infiltration. An 89-year-old woman presenting with right lower eyelid mass. Imaging modalities demonstrated a cystic orbital mass located beneath the globe and adjacent to enlarged lacrimal sac. Serological tests showed high IgG4 and normal IgG levels, measuring 242 and 1603?mg/dl, respectively. The orbital mass was surgically excised. Histologically, the excised tissue demonstrated marked inflammation with fibrosis surrounded by mononuclear epithelial cells. A variety of IgG and IgG4-positive plasma cells infiltrated the stroma. This patient was diagnosed as an IgG4-related lacrimal sac diverticulitis, based on current diagnostic criteria of IgG4-related disease. It is likely that IgG4-related inflammation occurs in a lacrimal sac diverticulum, which should be considered a differential diagnosis in inferior orbital tumors. PMID:24568363

Kase, Satoru; Suzuki, Yasuo; Shinohara, Toshiya; Kase, Manabu

2014-06-01

113

Primary malignant mixed Müllerian tumor arising from the mesorectum with a synchronous ovarian cancer: a case report and review of the literature  

Microsoft Academic Search

INTRODUCTION: Extragenital malignant mixed Müllerian tumor is an extremely rare presentation of malignant mixed Müllerian tumor, especially when combined with a synchronous ovarian cancer. CASE PRESENTATION: We report the clinical course and pathologic findings of a case of mesorectal malignant mixed Müllerian tumor with synchronous ovarian cancer, in a 50-year-old, gravida 0, para 0, Han Chinese woman with regular menstruation.

Chuang-Chi Huang; Cheng-Jen Ma; Wan-Ting Huang; Te-Fu Chan; Jaw-Yuan Wang

2011-01-01

114

Determination of the Thecal Sac Ending Using Magnetic Resonance Imaging: Clinical Applications in Craniospinal Irradiation  

Microsoft Academic Search

Purpose : To determine level of the thecal sac ending in unaffected individuals of young age-group and in patients with cerebrospinal fluid (CSF) seeding tumor using Magnetic Resonance Imaging (MRI). Material and Method : MRI of the lumbosacral spine of 253 cases (age range 1-40 years) had been reviewed. Of these, 20 cases were known having CSF seeding tumors. Two

Sith Phongkitkarun

115

Primary malignant melanoma of the lacrimal sac.  

PubMed

Primary malignant melanoma of the lacrimal sac is extremely rare. It is usually diagnosed at an advanced stage after excision or biopsy of a tumour. We treated a 59-year-old man with tearing and bloody discharge from the right eye. Clinical examination revealed a firm, localised mass at the inner canthus consistent with a lacrimal sac swelling. Sac washout demonstrated obstruction to entry into the lacrimal sac with a reflux of blood-stained fluid. The pathological findings and the immunohistochemical studies showed a malignant melanoma of the lacrimal sac. We performed radical surgery and radiation therapy. Follow-up 4 months after surgery revealed no evidence of recurrence. Because this tumour often presents with symptoms similar to dacryocystitis and may masquerade as a chronic dacryocystitis, ophthalmologists should be aware of this disease entity when encountered with patients with epiphora and mass in the medial canthal area. PMID:22891020

Li, Yang-Jun; Zhu, Shao-Jun; Yan, Hong; Han, Jing; Wang, Dan; Xu, Shuang

2012-01-01

116

Endolymphatic sac surgical anatomy and transmastoid decompression of the sac for the management of Ménière's disease.  

PubMed

Background: Decompression of the endolymphatic sac for Ménière's disease gives unpredictable results. This may be because the sac is difficult to identify and decompress accurately without causing surgical trauma. Methods: In order to test this idea, transmastoid decompression was simulated in 5 cadaver half heads and the anatomy of the endolymphatic sac was reviewed in a further 14 specimens. Results: The endolymphatic sac was found and confirmed by histology in all five simulated decompressions. A newly described feature, a trapezoid thickening of dura, was a useful guide. The review showed that the sac was constant proximally, but variable distally. The posterior semicircular canal, posterior fossa dura and sigmoid sinus are at risk during dissection. Conclusion: The endolymphatic sac may be identified on inspection by an overlying patch of dura, thereby reducing exploratory dissection. It is best to decompress the sac as far proximally as possible, whilst protecting the posterior semicircular canal. PMID:24905185

Locke, R R; Shaw-Dunn, J; O'Reilly, B F

2014-06-01

117

70. SAC command post construction, building 500, undated Offutt ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

70. SAC command post construction, building 500, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

118

Coexistence of Glomangioma and Yolk Sac Tumour in a Child: A Case Report  

PubMed Central

Glomus tumours (GTs) primarily arise from glomus bodies that are located in the dermis layer of skin. However, they can be encountered ectopically in most parts of the body. As a result of researches done in a 17-month-old male patient who prssented to us with complaint of an increasingly growing swelling, he was diagnosed with a yolk sac tumour. Chemotherapy was started and then, he was operated. GT was found inside the tumoural mass. Our patient, who is the first case according to our knowledge, where the concurrence of yolk sac and glomus tumours was reported, has been discussed in the light of literature.

Toy, Hatice; Gunel, Engin; Caliskan, Umran; Koksal, Yavuz

2014-01-01

119

Combined resection and multi-agent adjuvant chemotherapy for desmoplastic small round cell tumor arising in the abdominal cavity: Report of a case  

PubMed Central

Desmoplastic small round cell tumor (DSRCT) is a rare, highly aggressive malignancy with distinctive histological features: a nesting pattern of cellular growth within dense desmoplastic stroma, occurring in young population with male predominance. The mean survival period is only about 1.5-2.5 years. The tumor has co-expressed epithelial, muscle, and neural markers in immunohistochemical studies. This work reports a 27-year-old man presenting with hematemesis and chronic constipation. Serial studies including endoscopy, upper gastrointestinal series, abdominal computed tomography and barium enema study showed disseminated involvement of visceral organs. The patient underwent aggressive surgery and received postoperative adjuvant chemotherapy consisting of 5-fluorouracil, cyclophosphamide, etoposide, doxorubicin, and cisplatin. He survived without any disease for 20 mo after the surgery. No standard treatment protocol has been established. Aggressive surgery combined with postoperative multi-agent adjuvant chemotherapy is justified not only to relieve symptoms but also to try to improve the outcome in this advanced DSRCT young patient.

Chang, Chang-Cheng; Hsu, Jun-Te; Tseng, Jeng-Hwei; Hwang, Tsann-Long; Chen, Han-Ming; Jan, Yi-Yin

2006-01-01

120

Neuroendocrine carcinoma arising in a hepatitis C virus-infected liver: mechanism of the tumor development may be similar to that of development of pancreatic neuroendocrine cells.  

PubMed

We experienced a case of neuroendocrine carcinoma (NC). The tumor developed in the cirrhotic liver of a 62-year-old Japanese man who had been infected with hepatitis C virus. The tumor cells showed high N/C ratio, formed many rosettes, and expressed CD56, synaptophysin, HepPar1 and pancreatic and duodenal homeobox 1. MIB1 expression was 65%. Because both liver and pancreas are derived from a common endodermal layer during fetal development, we speculated that the tumor may have formed via the interaction of neurogenin 3, insulinoma-associated 1 gene and NeuroD/beta2, which are involved in the stage at which some pancreatic cells commit to becoming endocrine cells. Molecular analysis revealed that the NC had higher relative expression levels of mRNA of the three molecules than did the nontumorous liver. The results indicate that the NC in this patient may have formed via the same mechanism that acts in the development of pancreatic neuroendocrine cells. PMID:24629176

Masunaga, Atsuko; Inoue, Kazuaki; Mizukami, Hiroki; Hayashi, Takaki; Mitsuya, Toshiyuki

2014-02-01

121

Anaplastic spindle cell carcinoma, arising in a background of an ovarian mucinous cystic tumor: a case report with clinical follow up, review of the literature  

PubMed Central

Anaplastic carcinoma (AC) of spindle cell type is an exceedingly rare ovarian malignant neoplasm. The histo-genesis of these tumors is still controversial. Although it was first thought to carry an invariably unfavorable prognosis, recent data indicates that this does not apply to stage Ia tumors. To date, there have been less than ten cases of anaplastic spindle cell carcinoma reported in the medical literature. Furthermore, our case is the first time this tumor has been described in a 40-year-old female with malignant spindle cells merging with conventional high grade adeno-carcinoma. The differential diagnosis of spindle cell proliferation in the ovary will be discussed and their distinction using a panel of immunohistochemical stains. This report demonstrated that the findings of malignant spindle cell proliferation does not imply this entity to be carcinosarcoma. The distinction of AC from true sarcomas is important because of the poorer prognosis of the later compared with the quite favorable behavior of AC. However, such existence necessitates a careful tissue sampling for the logical distinction between AC and carcinosarcoma, which is critical for planning further management and ultimately the predictor of prognosis.

Hillesheim, Paul B; Farghaly, Hanan

2010-01-01

122

Primary lacrimal sac rhinosporidiosis with grossly dilated sac and nasolacrimal duct.  

PubMed

Rhinosporidiosis is a chronic infection of the mucous membranes of the upper respiratory tract. The authors report a case of primary lacrimal sac rhinosporidiosis with a grossly dilated sac and nasolacrimal duct as seen on CT dacryocystography. Despite a chronic infection of 12 years' duration, there was no involvement of conjunctiva, nasal, or nasopharyngeal mucosa. PMID:19454941

Pushker, Neelam; Kashyap, Seema; Bajaj, Mandeep S; Meel, Rachna; Sood, Archana; Sharma, Sanjay; Konkal, Venkatesh L

2009-01-01

123

Characterization of multiple promoters and transcript stability in the sacB-sacC gene cluster in Zymomonas mobilis.  

PubMed

In Zymomonas mobilis, the extracellular levansucrase (SacB) and extracellular sucrase (SacC) are involved in sucrose hydrolysis. Genes coding for these two enzymes (sacB and sacC) are arranged in a cluster in the genome and separated by a short intervening sequence. The level of sacC transcript was 12-fold higher than that of sacB transcript. On the other hand, transcript stability analysis in sucrose grown cultures revealed that the half-life of the sacB transcripts (153 s) was more than twofold higher than that of sacC transcript (66 s). The decay curves of sacB and sacC transcripts analyzed by the semi-quantitative RT-PCR correlated well with the decay curves of the respective enzyme activities. In the sacB promoter disruption mutant, Z. moblis BT2, the extracellular sucrase activity decreased from 2.6 to 2.0 U mg(-1) in sucrose medium due to the loss of SacB expression. The expression of sacC in the absence of the sacB promoter suggested that these two genes could be transcribed as different mRNAs. The promoter-lacZ fusion studies in Escherichia coli proved that the short intervening region acts as a strong promoter for the sacC gene. PMID:19415238

Senthilkumar, V; Rajendhran, J; Busby, S J W; Gunasekaran, P

2009-06-01

124

[Ultrasonic studies of the human embryo sac].  

PubMed

The growth of the embryo sac and of the uterus was determined between the 5th and 12th weeks of amenorrhoea in 91 normal pregnancies. 24 measurements of the ovaries and the uterus were made for each case by means of two-dimensional echograms. The averages, the standard deviations, the deviations of the mean, the correlation coefficients and the regression polynomials are reported for each of the dimensions measured. The results are compared with those obtained by other authors. The dimensions that gave the best indication of the evolution of gestation were the area and perimeter of the ultrasonic scans of the embryo sac and of the uterus as well as the cephalo-caudal diameter of the embryo sac. PMID:17436487

Levi, S; Erbsman, F

1974-01-01

125

Histopathology after Endolymphatic Sac Surgery for Meniere's Syndrome  

PubMed Central

Background The putative goal of sac surgery in Meniere’s syndrome is to promote the flow of endolymph from the labyrinth to the endolymphatic sac, and thereby relieving hydrops. There is scant published histopathological data whether sac surgery actually accomplishes this goal. Objective To determine if sac surgery relieves hydrops by examining the histopathologic changes in temporal bones obtained from individuals who had undergone sac surgery during life for Meniere’s syndrome. Methods Temporal bones were examined from 15 patients who had sac surgery. Data was collected on presence and severity of hydrops, histology of the sac, and whether the procedure relieved vertigo. Results The surgery failed to expose the sac in 5 cases; 4 of the 5 had relief from vertigo. The sac was exposed, but the shunt failed to reach the lumen of the sac in 8 cases; 4 of the 8 had relief from vertigo. The shunt was successfully placed within the lumen of the sac in two cases; both cases failed to experience relief from vertigo. Endolymphatic hydrops was present in all 15 cases. Conclusion Endolymphatic sac surgery does not relieve hydrops in patients with Meniere’s syndrome. Yet, sac surgery relieves vertigo in some patients, but the mechanism of such symptomatic relief remains unknown.

Chung, Jong Woo; Fayad, Jose; Linthicum, Fred; Ishiyama, Akira; Merchant, Saumil N.

2011-01-01

126

Hernia sacs: is histological examination necessary?  

PubMed

The hernia sac is a common surgical pathology specimen which can occasionally yield unexpected diagnoses. The College of American Pathologists recommends microscopic examination of abdominal hernias, but leaves submission of inguinal hernias for histology to the discretion of the pathologist. To validate this approach at a tertiary care centre, we retrospectively reviewed 1426 hernia sacs derived from inguinal, femoral and abdominal wall hernias. The majority of pathologies noted were known to the clinician, including herniated bowel, lipomas and omentum. A malignancy was noted in three of 800 inguinal hernias and seven of 576 abdominal wall hernias; five of these lesions were not seen on gross examination. Other interesting findings in hernia sacs included appendices, endometriosis, a perivascular epithelioid cell tumour, and pseudomyxoma peritoneii. All hernia sacs should be examined grossly as most pathologies are grossly visible. The decision to submit inguinal hernias for histology may be left to the discretion of the pathologist, but abdominal and femoral hernias should be submitted for histology. PMID:23794497

Wang, Tao; Vajpeyi, Rajkumar

2013-12-01

127

Undifferentiated carcinoma of the lacrimal sac: case report and review of literature.  

PubMed

A 55-year-old man presented with a 2-year history of right-sided epiphora and was referred to the Oculoplastic services for dacryocystorhinostomy. A 3-month progressive growth of a right medial canthal mass was found. MRI revealed an extraconal, lobulated, homogeneously enhancing mass in the lacrimal sac fossa with globe indentation and displacement supero-temporally. Following a transcanalicular needle biopsy which was suggestive of a carcinoma, he underwent medial orbitectomy and maxillectomy, through a lateral rhinotomy, with removal of puncta and canaliculi after ensuring no regional or systemic spread. The lacrimal sac tumor was encapsulated, extending superiorly above the medial canthal tendon and involving the nasolacrimal duct, and posteriorly along the medial orbital wall. After ensuring surgical margins were cleared of tumor infiltration, orbital reconstruction was performed with titanium plate and nasolabial flap. He has completed adjuvant radiotherapy with no evidence of tumor recurrence at 15 months of follow-up. PMID:21957907

Low, Jin Rong; Bian Ng, Siok; Sundar, Gangadhara

2011-12-01

128

72. SAC control center underground structure lower floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

72. SAC control center underground structure lower floor plan, drawing number 32-02-03, dated 1 February 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

129

79. SAC control center administration section first floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

79. SAC control center administration section first floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

130

78. SAC control center aboveground addition partial first floor plan, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

78. SAC control center aboveground addition partial first floor plan, drawing number AW30-02-09, dated 15 October, 1962 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

131

75. SAC control center underground structure middle floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

75. SAC control center underground structure middle floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

132

77. SAC control center administrative section basement floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

77. SAC control center administrative section basement floor plan, drawing number not listed, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

133

80. SAC control center administration section third floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

80. SAC control center administration section third floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

134

76. SAC control center underground structure upper floor plan, drawing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

76. SAC control center underground structure upper floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

135

13. SAC command center, weather center, underground structure, building 501, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. SAC command center, weather center, underground structure, building 501, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

136

71. SAC command post construction, building 500, January 20, 1987 ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

71. SAC command post construction, building 500, January 20, 1987 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

137

DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings  

ClinicalTrials.gov

Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Mixed Germ Cell Tumor; Ovarian Teratoma; Ovarian Yolk Sac Tumor; Testicular Choriocarcinoma; Testicular Embryonal Carcinoma; Testicular Seminoma; Testicular Teratoma; Testicular Yolk Sac Tumor

2014-02-17

138

Systemic Par-4 inhibits non-autochthonous tumor growth.  

PubMed

The tumor suppressor protein Par-4 (Prostate apoptosis response-4) is spontaneously secreted by normal and cancer cells. Extracellular Par-4 induces caspase-dependent apoptosis in cancer cell cultures by binding, via its effector SAC domain, to cell surface GRP78 receptor. However, the functional significance of extracellular Par-4/SAC has not been validated in animal models. We show that Par-4/SAC-transgenic mice express systemic Par-4/SAC protein and are resistant to the growth of non-autochthonous tumors. Consistently, secretory Par-4/SAC pro-apoptotic activity can be transferred from these cancer-resistant transgenic mice to cancer-susceptible mice by bone marrow transplantation. Moreover, intravenous injection of recombinant Par-4 or SAC protein inhibits metastasis of cancer cells. Collectively, our findings indicate that extracellular Par-4/SAC is systemically functional in inhibition of tumor growth and metastasis progression, and may merit investigation as a therapy. PMID:21613819

Zhao, Yanming; Burikhanov, Ravshan; Brandon, Jason; Qiu, Shirley; Shelton, Brent J; Spear, Brett; Bondada, Subbarao; Bryson, Scott; Rangnekar, Vivek M

2011-07-15

139

Characterizing the Mechanical Properties of Actual SAC105, SAC305, and SAC405 Solder Joints by Digital Image Correlation  

NASA Astrophysics Data System (ADS)

This paper presents the characterization of the mechanical properties of three lead-free solder alloys 95.5Sn-4.0Ag-0.5Cu (SAC405), 96.5Sn-3.0Ag-0.5Cu (SAC305), and 98.5Sn-1.0Ag-0.5Cu (SAC105) at the solder joint scale. Several actual ChipArray ® ball grid array (CABGA) packages were cross-sectioned, polished, and used as test vehicles. Compressive tests were performed using a nanocharacterization system over the temperature range of 25°C to 105°C. Images of the cross-sectioned solder joints were recorded by microscope during the tests. The recorded images were then processed by using a digital image correlation (DIC) program to calculate the displacement and strain fields on the solder joints. Finite-element method (FEM) modeling was used to extract the Poisson's ratio, Young's modulus, and coefficient of thermal expansion (CTE) of the solder alloys over the temperature range. The methodology developed in this paper enables characterization of the mechanical properties of the actual solder joints at low strain range with high accuracy.

Nguyen, T. T.; Yu, D.; Park, S. B.

2011-06-01

140

Aquarius/SAC-D Educational Wall Poster  

NSDL National Science Digital Library

This is a poster about the Aquarius/SAC-D satellite mission, with an image depicting the satellite in orbit. The back of the poster describes the mission's scientific goals and benefits, including the scientific value of maps of sea surface salinity. The Hands On Activities & Online Data Tools panel gives an overview of the classroom lessons and tools that are available on the mission website.

141

Aquarius/SAC-D Mission Overview  

NASA Technical Reports Server (NTRS)

Aquarius/SAC-D is a cooperative international mission developed between the National Aeronautics and Space Administration (NASA) of United States of America (USA) and the Comision Nacional de Actividades Espaciales (CONAE) of Argentina. The overall mission objective is to contribute to the understanding of the total Earth system and the consequences of the natural and man-made changes in the environment of the planet. Major themes are: ocean surface salinity, water cycle, climate, natural hazards and cryosphere.

Sen, Amit; Kim, Yunjin; Caruso, Daniel; Lagerloef, Gary; Colomb, Raul; Yueh, Simon; LeVine, David

2006-01-01

142

Angiosarcoma arising on rhinophyma.  

PubMed

We report an 82-year-old man who presented with a tumor which had developed over the previous year on the right nasal ala of a rhinophyma. Histopathological, immunohistochemical, and electron microscopic study confirmed the diagnosis of angiosarcoma on the head and neck. He was treated with radiotherapy of the tumor and cervical adenopathy, which developed later. The possible etiological and pathogenetic role of lymphedema due to inflammatory flares of rosacea on the nose is discussed, together with the histological and immunohistochemical data leading to the diagnosis of this tumor. PMID:11056431

Gallardo, M A; Bosch, R J; Vidal, L; Cabra, B; Rodrigo, A B; De Galvez, M V; Herrera, E

2000-01-01

143

Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors  

ClinicalTrials.gov

Childhood Embryonal Tumor; Childhood Extracranial Germ Cell Tumor; Childhood Extragonadal Germ Cell Tumor; Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Childhood Teratoma; Ovarian Embryonal Carcinoma; Ovarian Yolk Sac Tumor; Stage II Malignant Testicular Germ Cell Tumor; Stage IIA Ovarian Germ Cell Tumor; Stage IIB Ovarian Germ Cell Tumor; Stage IIC Ovarian Germ Cell Tumor; Stage III Malignant Testicular Germ Cell Tumor; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIC Ovarian Germ Cell Tumor; Testicular Choriocarcinoma and Yolk Sac Tumor; Testicular Embryonal Carcinoma

2014-02-28

144

A case of primary oncocytic adenocarcinoma of the lacrimal sac.  

PubMed

Lacrimal sac tumours are rare entities. Patients often present with epiphora, recurrent dacryocystitis, and/or a lacrimal sac mass. Neoplasms of the lacrimal system may conveniently be grouped into epithelial and non-epithelial types: papillomas are the most common benign epithelial tumours, while oncocytic adenocarcinomas are extremely rare. Here we report a case of primary oncocytic adenocarcinoma of the lacrimal sac in a 56-year-old man. PMID:21747898

Zhang, Jingxue; Jianmin; Wang, Ningli; Shi, Jitong; Ge, Xin

2009-01-01

145

Ribosome display for the selection of Sac7d scaffolds.  

PubMed

Combinatorial libraries of Sac7d have proved to be a valuable source of proteins with favorable biophysical properties and novel ligand specificities, so-called Nanofitins. Thus, Sac7d represents a promising scaffold alternative to antibodies for biotechnological and potentially clinical applications. We describe here the methodology for the construction of a library of Sac7d and its use for selection by ribosome display. PMID:22094814

Mouratou, Barbara; Béhar, Ghislaine; Paillard-Laurance, Lauranne; Colinet, Stéphane; Pecorari, Frédéric

2012-01-01

146

Bloody epiphora secondary to a lacrimal sac varix.  

PubMed

This is a report of a 57-year-old female patient who sought treatment for multiple episodes of bloody epiphora. A CT of her orbits revealed enhancement and enlargement of her left lacrimal sac and duct. A biopsy was then performed, which showed a varix involving the wall of the lacrimal sac. To the authors' knowledge, this is the first reported case of a lacrimal sac varix causing bloody epiphora. PMID:23446307

Lee, Henry; Herreid, Peter A; Sires, Bryan S

2013-01-01

147

Apoptosis and tumor resistance conferred by Par-4.  

PubMed

Par-4 is a tumor suppressor protein with a pro-apoptotic function. Epigenetic silencing of Par-4 is seen in diverse tumors and Par-4 knockout mice develop spontaneous tumors in various tissues. Endogenous Par-4 is essential for sensitization of cells to diverse apoptotic stimuli, whereas ectopic expression of Par-4 can selectively induce apoptosis in cancer cells. The cancer-specific pro-apoptotic action of Par-4 resides in its centrally located SAC domain. This review emphasizes the role of Par-4/SAC in apoptosis and tumor resistance. SAC transgenic mice display normal development and life span, and, most importantly, are resistant to spontaneous, as well as oncogene-induced, autochthonous tumors. The tumor resistant phenotype and undetectable toxicity of SAC in vivo suggests the SAC domain possesses tremendous therapeutic potential. PMID:18836307

Zhao, Yanming; Rangnekar, Vivek M

2008-12-01

148

85. Command HQ. SAC control center (MOD) new work cross ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

85. Command HQ. SAC control center (MOD) new work cross section, drawing number AW-30-02-07, dated 7 February, 1962 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

149

83. SAC control center administration section and underground structure elevations ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

83. SAC control center administration section and underground structure elevations and sections, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

150

86. SAC control center administration section underground structure and theater ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

86. SAC control center administration section underground structure and theater sections and elevations, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

151

82. SAC control center underground structure sections and unit substation ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

82. SAC control center underground structure sections and unit sub-station details, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

152

DNA binding and bending by Sac7d is stepwise.  

PubMed

Which came first? Using thermodynamic cycles constructed from experimental measures of the binding free energy and free energy simulations, we have shown that binding of Sulfolobus acidocaldarius protein Sac7d to DNA occurs before DNA bending, thus indicating that a conformational selection mechanism is unlikely to be operative in Sac7d binding. PMID:23853062

Spiriti, Justin; van der Vaart, Arjan

2013-08-19

153

EGG SAC STRUCTURE OF ZYGIELLA X -NOTATA (ARACHNIDA, ARANEIDAE)  

Microsoft Academic Search

A detailed examination of the egg sac of Zygiella x-notata (Clerck 1757) revealed its structure, composition and different fibers. All egg sacs were composed of a basic layer, an insulation layer and an outer layer. The insulation layer consisted of two layers of cylindrical (or tubuliform) fibers with different diameters and probably with different mechanical properties. Knowing the complete struc-

T. Gheysens; L. Beladjal; K. Gellynck; E. Van Nimmen; L. Van Langenhove; J. Mertens

2005-01-01

154

Physicochemical Properties of Sn-Zn and SAC + Bi Alloys  

NASA Astrophysics Data System (ADS)

Applying the discharge crucible (DC) method, the viscosity, density, and surface tension were determined for Sn-9Zn and Sn-2.92Ag-0.4Cu-3.07Bi (SAC + Bi) alloys. For comparison, the dilatometric, maximum bubble pressure, and capillary flow methods were used for measurements of these same physicochemical properties for the Sn-2.92Ag-0.4Cu-3.07Bi (SAC + Bi) alloy. The measurements were performed for Sn-9Zn and SAC + Bi alloys in the temperature range from 513 K to 723 K and 530 K to 1180 K, respectively. The experimental data obtained show that addition of Bi to SAC increases the density and decreases the surface tension and viscosity in comparison with SAC solder. Additionally it was found that the properties studied by different methods (maximum bubble pressure, dilatometric, capillary flow, and discharge crucible) were almost identical.

Gancarz, Tomasz; Pstru?, Janusz; G?sior, W?adys?aw; Henein, Hani

2013-02-01

155

Sunitinib in Treating Young Patients With Refractory Solid Tumors  

ClinicalTrials.gov

Central Nervous System Metastases; Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Recurrent Childhood Central Nervous System Embryonal Tumor; Unspecified Childhood Solid Tumor, Protocol Specific

2014-01-27

156

Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors  

ClinicalTrials.gov

Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Unspecified Childhood Solid Tumor, Protocol Specific

2013-05-01

157

Malignant mediastinal germ cell tumor with pure hepatoid differentiation.  

PubMed

We describe a germ cell tumor of anterior mediastinal origin, with pure hepatoid differentiation and elevated serum AFP in a 41-year-old man. This is the first report of such a neoplasm analyzed by conventional stains and immunohistochemistry. Hepatocellular differentiation was proved by immunoreactivity with HepPar-1 and alpha-fetoproein (AFP), membranous expression of carcinoembryonic antigen (CEA-poly) in a canalicuar pattern, and focal expression of cytokeratin 19 in abortive ductular structures. Our investigation shows that mediastinal germ cell tumors with hepatoid components typically arise in middle-aged men; they are of pure hepatoid differentiation, as demonstrated here, or exclusively associated with yolk sac structures. PMID:12530574

Theuerkauf, Ingo; Axmann, Cristoph; Wolff, Martin; Tschubel, Klaus; Fischer, Hans-Peter

2002-01-01

158

Cellular Schwannoma Arising from Sigmoid Mesocolon Presenting as Torsion  

PubMed Central

Schwannomas are a type of peripheral nerve sheath tumors with clinically indolent behavior. Though, they can occur anywhere in body, the incidence in retroperitoneum, mediastinum, and pelvis is exceedingly rare. We present a case of a 58-year-old female with a massive twisted tumor arising from sigmoid mesocolon. The tumor was diagnosed to be a case of cellular schwannoma, an exceedingly rare tumor in this location with rare presentation.

Adlekha, S; Chadha, T

2013-01-01

159

Retinoid signaling regulates primitive (yolk sac) hematopoiesis.  

PubMed

It is known from nutritional studies that vitamin A is an important factor for normal hematopoiesis, though it has been difficult to define its precise role. The vitamin A-deficient (VAD) quail embryo provides an effective ligand "knockout" model for investigating the function of retinoids during development. The VAD embryo develops with a significant reduction in erythroid cells, which has not been noted previously. Activation of the primitive erythroid program and early expression of the erythroid marker GATA-1 occurs, though GATA-1 levels eventually decline, consistent with the erythropoietic and hemoglobin deficits. However, from its early stages, the GATA-2 gene fails to be expressed normally in VAD embryos. The bone morphogenetic protein (BMP)-signaling pathway regulates GATA-2, and BMP4 expression becomes reduced in the caudal embryonic region of VAD embryos. Adding BMP4 to cultured VAD-derived explants rescues the production of erythroid cells, whereas normal embryos cultured in the presence of the BMP antagonist noggin are defective in primitive hematopoiesis. We find that cell clusters of primitive blood islands undergo an inappropriate program of apoptosis in the VAD embryo, which can explain the deficit in differentiated primitive blood cells. We propose that vitamin A-derived retinoids are required for normal yolk sac hematopoiesis and that an embryonic retinoid-BMP-GATA-2 signaling pathway controls progenitor cell survival relevant to primitive hematopoiesis. PMID:11895770

Ghatpande, Satish; Ghatpande, Ashwini; Sher, Justin; Zile, Maija H; Evans, Todd

2002-04-01

160

A comparison of the creep behaviour of joint-scale SAC105 and SAC305 solder samples under shear conditions  

Microsoft Academic Search

This study compares the creep behavior of joint-scale Sn1.0Ag0.5Cu (SAC105) and Sn3.0Ag0.5Cu (SAC305) solder samples under shear loading. The basis of the comparison is experimentally derived Anand viscoplastic constitutive models for the alloys. A series of monotonic constant shear stress and constant shear strain rate tests was conducted at temperatures of 20°C, 50°C, 75°C and 100°C for SAC105 in order

Cillian Burke; Jeff Punch

2012-01-01

161

Establishment of a quantitative mouse dorsal air sac model and its application to evaluate a new angiogenesis inhibitor.  

PubMed

We have developed an improved mouse dorsal air sac model for quantifying in vivo tumor-induced angiogenesis. In our improved model, tumor angiogenesis is determined by measuring the blood volume in an area of skin held in contact with a tumor cell-containing chamber, using 51Cr-labeled red blood cells (RBC). The blood volume induced by murine B16-BL6 melanoma cells increased linearly with the cell number in the range from 2 x 10(5) to 5 x 10(6). Ten of 11 human tumor cell lines examined induced a significant increment in blood volume. For three representative human tumor cell lines (A549, WiDr. and HT1080 cells) that showed different angiogenic potencies, the levels of vascular endothelial growth factor (VEGF) produced by the tumor cells cultured under conditions of hypoxia and high cell density were correlated with the degree of in vivo angiogenesis. Using the improved model, it was confirmed that TNP-470, a well-known inhibitor, and borrelidin, an antibiotic from Streptomyces rochei, significantly inhibited the WiDr cell-induced angiogenesis. Borrelidin also inhibited spontaneous lung metastasis of B16-BL6 melanoma at the same dose that inhibited angiogenesis. Our results suggest that the improved mouse dorsal air sac model can be used for simple and quantitative measurement of tumor-induced angiogenesis and its inhibition. PMID:10757446

Funahashi, Y; Wakabayashi, T; Semba, T; Sonoda, J; Kitoh, K; Yoshimatsu, K

1999-01-01

162

[Spanish adaptation of Hobfoll's Strategic Approach to Coping Scale (SACS)].  

PubMed

The present research adapted the Strategic Approach to Coping Scale (SACS), developed by Hobfoll and colleagues, to the Spanish population. SACS is an instrument derived from Hobfoll's Conservation of Resources Theory, which emphasises the contribution of social factors to coping processes. This instrument assesses coping strategies in 9-subscales, organised in three dimensions: orientation to the problem (active/passive), use of social resources (prosocial/antisocial), and orientation to others involved (direct/indirect). The Spanish version, administered to a non-clinical sample (N= 767), found 7-subscales structured in prosocial/antisocial, active/passive and reflexive/intuitive dimensions, with adequate reliability and construct validity. To conclude, the Spanish SACS is a potentially useful and reliable instrument for research and clinical purposes, mainly in areas in which social components need to be explicitly considered. PMID:22748740

Pedrero Pérez, Eduardo J; Santed Germán, Miguel A; Pérez García, Ana M

2012-01-01

163

Aquarius and the Aquarius/SAC-D Mission  

NASA Technical Reports Server (NTRS)

Aquarius is a combination L-band radiometer and scatterometer designed to map the salinity field at the ocean surface from space. It will be flown on the Aquarius/SAC-D mission, a partnership between the USA space agency (NASA) and Argentine space agency (CONAE). The mission is composed of two parts: (a) The Aquarius instrument being developed as part of NASA.s Earth System Science Pathfinder (ESSP) program; and (b) SAC-D the fourth spacecraft service platform in the CONAE Satellite de Aplicaciones Cientificas (SAC) program. The primary focus of the mission is to monitor the seasonal and interannual variations of the salinity field in the open ocean. The mission also meets the needs of the Argentine space program for monitoring the environment and for hazard detection and includes several instruments related to these goals.

LeVine, D. M.; Lagerloef, G. S. E.; Torrusio, S.

2010-01-01

164

Yolk Sac Mesenchymal Progenitor Cells from New World Mice (Necromys lasiurus) with Multipotent Differential Potential  

PubMed Central

Fetal membranes are abundant, ethically acceptable and readily accessible sources of stem cells. In particular, the yolk sac is a source of cell lineages that do not express MHCs and are mainly free from immunological incompatibles when transferred to a recipient. Although data are available especially for hematopoietic stem cells in mice and human, whereas other cell types and species are dramatically underrepresented. Here we studied the nature and differentiation potential of yolk sac derived mesenchymal stem cells from a New World mouse, Necromys lasiurus. Explants from mid-gestation were cultured in DMEM-High glucose medium with 10% defined fetal bovine serum. The cells were characterized by standard methods including immunophenotyping by fluorescence and flow cytometry, growth and differentiation potential and tumorigenicity assays. The first adherent cells were observed after 7 days of cell culture and included small, elongated fibroblast-like cells (92.13%) and large, round epithelial-like cells with centrally located nuclei (6.5%). Only the fibroblast-like cells survived the first passages. They were positive to markers for mesenchymal stem cells (Stro-1, CD90, CD105, CD73) and pluripotency (Oct3/4, Nanog) as well as precursors of hematopoietic stem cells (CD117). In differentiation assays, they were classified as a multipotent lineage, because they differentiated into osteogenic, adipogenic, and chondrogenic lineages and, finally, they did not develop tumors. In conclusion, mesenchymal progenitor cells with multipotent differentiation potential and sufficient growth and proliferation abilities were able to be obtained from Necromys yolk sacs, therefore, we inferred that these cells may be promising for a wide range of applications in regenerative medicine.

Favaron, Phelipe Oliveira; Mess, Andrea; Will, Sonia Elisabete; Maiorka, Paulo Cesar; de Oliveira, Moacir Franco; Miglino, Maria Angelica

2014-01-01

165

Teratoid Wilms' tumor - A rare renal tumor  

PubMed Central

Teratoid Wilms’ tumor is an extremely rare renal tumor. We report a case of unilateral teratoid Wilms’ tumor in a 4-year-old girl. The patient was admitted with a right-sided abdominal mass. The mass was arising from the right kidney. Radical nephrectomy was done and the patient had an uneventful recovery. Histopathology report showed teratoid Wilms’ tumor.

Mukhopadhyay, Biswanath; Shukla, Ram Mohan; Mukhopadhyay, Madhumita; Mandi, Sabitri; Roy, Dipankar; Bhattacharya, Malay K.

2011-01-01

166

Free-floating pyogenic granuloma of the lacrimal sac.  

PubMed

The authors report a 13-month-old girl with chronic dacryocystitis, and history of three times probing and once inferior turbinate infracture. She underwent dacryocystorhinostomy due to failure of previous procedures. During surgery a free floating reddish mass was extracted from the lacrimal sac. Histopathologic examination revealed the mass to be a pyogenic granuloma. PMID:24215136

Bagheri, Abbas; Rafati, Nasrin; Salim, Reza Erfanian; Yazdani, Shahin

2014-04-01

167

Endolymphatic sac obliteration for large vestibular aqueduct syndrome.  

PubMed

The objective of this study was to investigate the effects of endolymphatic sac obliteration for stabilization of progressive hearing loss in patients with the large vestibular aqueduct syndrome. This was a retrospective case review conducted at a private neurootologic office in a metropolitan area. Seven ears in six patients were subjected to surgery for obliteration of the endolymphatic sac in an effort to stabilize progressive hearing loss associated with the large vestibular aqueduct syndrome. The study population was composed of four boys and two girls 4-17 years of age. The large vestibular aqueduct was unilateral in two patients and bilateral in four patients. All seven ears demonstrated progressive sensorineural hearing loss preoperatively. Surgical tissue obliteration was performed via a transmastoid approach in seven ears. The main outcome measure was comparison of pre- and postoperative hearing levels and stability. Magnetic resonance imaging also was performed in all cases at least 6 months postoperatively to determine patency of the endolymphatic sac and vestibular aqueduct. Six of seven ears maintained stable hearing during the follow-up period, which ranged from 6 months to 6 years (mean 3.2 years). One patient showed continued progression of hearing loss postoperatively. All seven ears demonstrated continued obliteration on postoperative imaging studies. Surgical obliteration of the endolymphatic sac may stabilize hearing in patients with the large vestibular aqueduct syndrome and progressive hearing loss. These results support the theory of pressure or fluid reflux into the labyrinth as a cause of progressive hearing loss in these patients. PMID:8989959

Wilson, D F; Hodgson, R S; Talbot, J M

1997-01-01

168

Planar feature fitting based on Multi-BaySAC algorithm  

NASA Astrophysics Data System (ADS)

To tackle the problem that classic RANSAC (Random Sample Consensus) is limited by the assumption that a single model accounts for all of the data inliers, an algorithm of multi-planar-feature fitting from 3D point cloud based on BaySAC algorithm (Bayes Sample Consensus) is proposed (called multiBaySAC). First, as the mathematical models of most of primitives to be fitted are determinate, a statistical algorithm of hypothesis model parameters histogram is proposed to detect potential planar features. Instead of assuming constant prior probabilities of data points and choosing initial data sets by random as RANSAC, we then implement a conditional sampling method -- BaySAC for robust parameters estimation of potential planar features, by computing the prior probability of each data point and updating the inlier probabilities using simplified Bayes' rule. For the purpose of multiple feature fitting, the sequential application of the above procedure is implemented following the removal of the detected set of inliers. The proposed approach is tested with point cloud data of buildings acquired by RIEGL VZ-400 laser scanner. The results show that the proposed Multi-BaySAC can achieve high computation efficiency and fitting accuracy of multiple planar feature fitting.

Li, Zhen; Kang, Zhizhong

2013-10-01

169

Endoscopic dacryocystorhinostomy: creation of a large marsupialized lacrimal sac.  

PubMed

This retrospective study describes and evaluates the effectiveness of a modified technique of conventional endoscopic dacryocystorhinostomy (DCR) that minimizes the obstruction of a neo-ostium by creating an enlarged marsupialized lacrimal sac using mucosal flaps. Forty-two patients who had undergone 46 endoscopic DCR at a tertiary medical center, from 2002 to 2004, for correction of lacrimal system obstruction were investigated. The surgical technique involves elevation of a nasal mucosal flap, full sac exposure using a power drill, and shaping of the mucosal flap to cover denuded bone and juxtapose exposed sac mucosa. Postoperative symptoms and endoscopic findings of the neo-ostium were evaluated. Mean duration of follow-up was 5.9 months. An eighty-three percent primary success rate was observed, without any serious complications. Obstruction of the neo-ostium with granulation tissue was observed in eight cases, among which six underwent revision with success in all cases. Overall, 44 (96%) of 46 cases experienced surgical successes. Endoscopic DCR, a procedure in which a large marsupialized lacrimal sac is created from mucosal flaps, yields a very satisfactory success rate with straightforward and highly successful revision available for those in whom the primary procedure yields a substandard result. PMID:16891819

Jin, Hong-Ryul; Yeon, Je-Yeob; Choi, Mi-Young

2006-08-01

170

New correlation algorithm between FAC and OATS\\/SAC  

Microsoft Academic Search

This paper proposes the new correlation algorithm between the fully anechoic chamber (FAC) and the test facilities with ground plane such as open area test site (OATS), semi-anechoic chamber (SAC), etc. in order to use the FAC as an alternative test facility. The approach is to model the EUT as an equivalent set of multipoles. Assuming the EUT is electrically

Jong Hwa Kwon; Hyun H. Park; Hyung Do Choi

2003-01-01

171

Air Sacs of Respiratory Origin in Some Procellariiform Birds.  

National Technical Information Service (NTIS)

The purpose of this paper is to present details of the air-sac system in three species of the order Procellariiformes--the Laysan Albatross, Diomedea immutabilis; the Wedge-tailed Shearwater, Puffinus pacificus; and the Christmas Island Shearwater, Puffin...

M. P. Hamlet H. I. Fisher

1966-01-01

172

Torsion of an indirect hernia sac causing acute scrotum  

Microsoft Academic Search

A 6-year-old boy presented with an acute scrotum and was found at surgical exploration to have torsion and infarction of an indirect hernia sac. This represents the sixth reported case of this entity in the literature. The pediatric surgical specialist and those in the acute care setting should be aware of this consideration in the differential diagnosis of the acute

Jeremy B Myers; Mark A Lovell; Robert S Lee; Peter D Furness; Martin Koyle

2004-01-01

173

Sclerotic changes around the endolymphatic sac in human temporal bones  

Microsoft Academic Search

We used light microscopy to study 87 human temporal bones (from 47 cases) with no known otological disorders, and found that certain cases had sclerotic changes around the endolymphatic duct and sac. Changes included fibrosis, hyalinization, psammoma formation, and thickened vascular walls. The findings were subjected to statistical analysis, which indicated that most of the changes could be positively correlated

Noboru Sakai; Makoto Igarashi; Kazuhiro Ohashi; Masanori Ishii

1985-01-01

174

Tetrasporic Embryo-Sac Formation in Trisomic Sectors of Maize.  

PubMed

Nondisjunction in mitotic divisions occurs spontaneously at a low frequency in somatic and germinal tissue in maize and results in sectors of trisomic cells. When this happens with chromosome 3 and in germinal tissue the embryo sac development is changed from the normal monosporic type to a tetrasporic type which is common in some species but not in maize. PMID:17733621

Neuffer, M G

1964-05-15

175

Aquarius\\/SAC-D Ocean Salinity Mission Science Overview  

Microsoft Academic Search

Scheduled for launch in 2009, the international Aquarius\\/SAC-D satellite will begin a mission to map the global sea surface salinity (SSS) field and its variability from space. The overarching scientific goal is to provide the essential data to study the interactions between the ocean circulation, global water cycle and climate. Key scientific issues to address are (1) mapping large expanses

G. S. E. Lagerloef; Y. Chao; F. Raul Colomb

2006-01-01

176

81. SAC control center aboveground addition elevations, drawing number AW300209, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

81. SAC control center aboveground addition elevations, drawing number AW-30-02-09, dated 15 October, 1962 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

177

45. SAC conference room 2A8, second floor, Dwing, building 500, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. SAC conference room 2A8, second floor, D-wing, building 500, looking southeast - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

178

Effect of Yolk-SAC Fractions on Viral and Rickettsial Infectivity.  

National Technical Information Service (NTIS)

The rickettsia of Rocky Mountain spotted fever, Rickettsia rickettsii, under certain conditions was more stable in partially purified suspensions than in crude yolk-sac suspensions. To demonstrate the presence in yolk sac of substances detrimental to infe...

R. F. Wachter E. N. Gilman

1968-01-01

179

Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice  

PubMed Central

Tumor blood vessels are leaky and immature, which causes inadequate blood supply to tumor tissues resulting in hypoxic microenvironment and promotes metastasis. Here we have explored tumor vessel modulating activity of Sac-1004, a recently developed molecule in our lab, which directly potentiates VE-cadherin-mediated endothelial cell junction. Sac-1004 could enhance vascular junction integrity in tumor vessels and thereby inhibit vascular leakage and enhance vascular perfusion. Improved perfusion enabled Sac-1004 to have synergistic anti-tumor effect on cisplatin-mediated apoptosis of tumor cells. Interestingly, characteristics of normalized blood vessels namely reduced hypoxia, improved pericyte coverage and decreased basement membrane thickness were readily observed in tumors treated with Sac-1004. Remarkably, Sac-1004 was also able to inhibit lung and lymph node metastasis in MMTV and B16BL6 tumor models. This was in correlation with a reduction in epithelial-to-mesenchymal transition of tumor cells with considerable diminution in expression of related transcription factors. Moreover, cancer stem cell population dropped substantially in Sac-1004 treated tumor tissues. Taken together, our results showed that direct restoration of vascular junction could be a significant strategy to induce normalization of tumor blood vessels and reduce metastasis.

Agrawal, Vijayendra; Maharjan, Sony; Kim, Kyeojin; Kim, Nam-Jung; Son, Jimin; Lee, Keunho; Choi, Hyun-Jung; Rho, Seung-Sik; Ahn, Sunjoo; Won, Moo-Ho; Ha, Sang-Jun; Koh, Gou Young; Kim, Young-Myeong; Suh, Young-Ger; Kwon, Young-Guen

2014-01-01

180

Teratogenic effects of amniotic sac puncture: a mouse model.  

PubMed Central

The possibility of an association between chorionic villus sampling (cvs) and limb abnormalities has prompted a review of the relevant experimental data. Although a vascular aetiology is favoured by many at present, the possibility exists that a proportion of cases may be caused by oligohydramnios secondary to inadvertent amniotic sac puncture. A mouse model of amniotic puncture syndrome has been developed to study the craniofacial and limb abnormalities produced by this procedure. Pregnant mice were anaesthetised and a laparotomy performed. One uterine horn was exteriorised, and the amniotic sacs punctured through the wall of the uterus with either a 21 gauge or a 25 gauge needle. The conceptuses in the contralateral uterine horn acted as controls. The mice were all killed on d 19 of pregnancy (day of finding a vaginal plug = d 1 of pregnancy) by cervical dislocation, and the morphological features of the embryos examined in detail. In a preliminary study, amniotic sac puncture was carried out on d 12, 13, 14, 15 or 16 of pregnancy, with either a 21 or a 25 gauge needle. Since the highest rates of palatal defects and limb deformities were observed following amniotic sac puncture using a 21 gauge needle, when this procedure was carried out on either d 13 or 14 of pregnancy, the main study was undertaken using a 21 gauge needle on these two days of pregnancy. Of 102 embryos in which amniotic sac puncture was carried out on d 13, 53% survived to d 19. Of the latter, 35% had a cleft palate, 61% had one or more morphologically abnormal limbs, and 43% had an abnormal tail. When amniotic sac puncture was carried out on d 14 of pregnancy, of 83 embryos subjected to this procedure, 81% survived to d 19. Of the latter, 27% had a cleft palate, 39% had one or more morphologically abnormal limbs, and 19% had an abnormal tail. In the controls, of 86 and 61 embryos isolated respectively from the d 13 and 14 mice, the survival rates were 97 and 90%, respectively. Palatal, limb and tail abnormalities were not observed in the control series. Tentative relationships are drawn between cvs and amniocentesis-associated abnormalities, the Robin sequence and their rodent phenocopies. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4

MacIntyre, D J; Chang, H H; Kaufman, M H

1995-01-01

181

Circular dichroism spectra of uridine derivatives: ChiraSac study.  

PubMed

The experimental circular dichroism (CD) spectra of uridine and NH2-uridine that were different in the intensity and shape were studied in the light of the ChiraSac method. The theoretical CD spectra at several different conformations using the symmetry-adapted-cluster configuration-interaction (SAC-CI) theory largely depended on the conformational angle, but those of the anti-conformers and the Boltzmann average reproduced the experimentally obtained CD spectra of both uridine and NH2-uridine. The differences in the CD spectra between the two uridine derivatives were analyzed by using the angle ? between the electric transition dipole moment (ETDM) and the magnetic transition dipole moment (MTDM). PMID:24679161

Miyahara, Tomoo; Nakatsuji, Hiroshi; Wada, Takehiko

2014-04-24

182

Mission mode attitude control for SAC-B  

NASA Astrophysics Data System (ADS)

We describe the Mission mode attitude control of the scientific Argentine satellite SAC-B. Based on the mathematical model of the system, a Linear Quadratic Regulator (LQR) controller with integral action has been designed. Robustness against parametric and dynamic uncertainty is evaluated. Performance is defined in terms of pointing accuracy under sets of perturbations and measurement noise, and evaluated by means of the singular value plots. Several pointing maneuvers and failure conditions are simulated and plotted.

Anigstein, Pablo A.; Pena, Ricardo S. Sanchez; Yasielski, Roberto; Jauregui, Marcela; Alonso, Roberto

183

Torsion of an indirect hernia sac causing acute scrotum.  

PubMed

A 6-year-old boy presented with an acute scrotum and was found at surgical exploration to have torsion and infarction of an indirect hernia sac. This represents the sixth reported case of this entity in the literature. The pediatric surgical specialist and those in the acute care setting should be aware of this consideration in the differential diagnosis of the acute scrotum. PMID:14694389

Myers, Jeremy B; Lovell, Mark A; Lee, Robert S; Furness, Peter D; Koyle, Martin

2004-01-01

184

Mutation of SAC1, an Arabidopsis SAC Domain Phosphoinositide Phosphatase, Causes Alterations in Cell Morphogenesis, Cell Wall Synthesis, and Actin Organization  

Microsoft Academic Search

SAC (for suppressor of actin) domain proteins in yeast and animals have been shown to modulate the levels of phosphoinositides, thereby regulating several cellular activities such as signal transduction, actin cytoskeleton organiza- tion, and vesicle trafficking. Nine genes encoding SAC domain-containing proteins are present in the Arabidopsis thaliana genome, but their roles in plant cellular functions and plant growth and

Ruiqin Zhong; David H. Burk; C. Joseph Nairn; Alicia Wood-Jones; W. Herbert Morrison III; Zheng-Hua Yea

2005-01-01

185

Nonmalignant Tumors of the Orbit  

Microsoft Academic Search

\\u000a Most orbital tumors are nonmalignant. Nonmalignant orbital tumors can arise from any of the structures within the orbit, including\\u000a blood vessels, fat, nerves, lacrimal gland, and connective tissue. Nonmalignant orbital tumors can be grouped into cystic\\u000a lesions, vascular tumors, lymphoproliferative lesions, inflammatory lesions, mesenchymal tumors, neurogenic tumors, and lacrimal\\u000a gland tumors. Although most orbital tumors are benign, their location may

Eric M. Hink; Vikram Durairaj

186

Tumor Immunology  

Microsoft Academic Search

Most tumors of the liver arise from hepatocytes giving rise to hepatocellular carcinoma (HCC), or biliary epithelial cells\\u000a giving rise to cholangiocarcinoma (CCA), or the tumors are metastatic, often from colon cancer. HCC and CCA are associated\\u000a with other diseases of the liver, which often incite chronic inflammation. In the case of HCC, chronic viral hepatitis is\\u000a often present, although

Christopher L. Bowlus

187

Adenoid glioblastoma arising in a patient with neurofibromatosis type-1.  

PubMed

An unusual case of glioblastoma with adenoid structures arising in a 30-year-old Japanese woman with neurofibromatosis type-1 (NF1) is reported. The patient was admitted to University of Miyazaki Hospital, complaining of headache, nausea and vomiting. From the neuroradiological findings the patient was diagnosed as having glioblastoma, and the tumor was surgically resected. Histologically, the tumor consisted mainly of dark basophilic cells showing prominent tubular or glandular structures surrounded by large eosinophilic cells, in addition to the typical glioblastoma features in the periphery of the tumor. Both cells showed strong stainability with glial fibrillary acidic protein (GFAP) and S-100 protein immunohistochemically, so that the tumor was classified as adenoid glioblastoma. Several cases of glioblastoma have been reported to reveal the adenoid or epithelioid differentiation. The patients with NF1 are prone to develop malignant tumors including glioblastoma, but no cases representing adenoid glioblastoma associated with NF1 have been reported. This report is considered to be the first case of adenoid glioblastoma arising in a patient with NF1. The recognition of the existence of epithelial features of glioblastoma would be important in differential diagnosis of epithelioid tumors of the brain including metastatic carcinomas. PMID:15943792

Miyata, Shiro; Sugimoto, Tetsuaki; Kodama, Takao; Akiyama, Yutaka; Nakano, Shinichi; Wakisaka, Shinichiro; Itoh, Hiroshi; Kataoka, Hiroaki

2005-06-01

188

SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase  

PubMed Central

Background SacPox, an enzyme from the extremophilic crenarchaeal Sulfolobus acidocaldarius (Sac), was isolated by virtue of its phosphotriesterase (or paraoxonase; Pox) activity, i.e. its ability to hydrolyze the neurotoxic organophosphorus insecticides. Later on, SacPox was shown to belong to the Phosphotriesterase-Like Lactonase family that comprises natural lactonases, possibly involved in quorum sensing, and endowed with promiscuous, phosphotriesterase activity. Results Here, we present a comprehensive and broad enzymatic characterization of the natural lactonase and promiscuous organophosphorus hydrolase activities of SacPox, as well as a structural analysis using a model. Conclusion Kinetic experiments show that SacPox is a proficient lactonase, including at room temperature. Moreover, we discuss the observed differences in substrate specificity between SacPox and its closest homologues SsoPox and SisLac together with the possible structural causes for these observations.

2014-01-01

189

Bacterial and mycoplasmal flora of the healthy camelid conjunctival sac.  

PubMed

Healthy conjunctival sacs of 88 animals of 3 species of captive camelids (Lama glama, Lama guanicoe, Lama pacos) and llama-guanaco hybrids were sampled for bacterial and mycoplasmal flora. Mycoplasmas were not isolated from any animal. Eleven genera of bacteria were isolated. The most frequent isolates were Staphylococcus epidermidis and Pseudomonas spp. Nine varieties of Pseudomonas were found, which represented at least 3 Pseudomonas species. Many of the bacterial isolates (especially the pseudomonads) are potential pathogens in the eyes of these camelids. PMID:1892259

Gionfriddo, J R; Rosenbusch, R; Kinyon, J M; Betts, D M; Smith, T M

1991-07-01

190

Fungal flora of the healthy camelid conjunctival sac.  

PubMed

Swab specimens for fungal isolation were collected from the healthy conjunctival sacs of 3 species of captive camelids (Lama glama, L guanicoe, L pacos) and llama-guanaco hybrids. Fungi were collected from over half the animals in winter (53%) and summer (56%). Fungal species of 10 genera were isolated. In both seasons, Aspergillus was the most commonly isolated genus; at least 9 species of Aspergillus were found. The fungal organisms isolated were similar to those found in healthy eyes of other domestic animals and may represent a random seeding from the environment where they are ubiquitous. PMID:1524286

Gionfriddo, J R; Gabal, M A; Betts, D M

1992-05-01

191

Glioneuronal Tumors  

Microsoft Academic Search

\\u000a Neuronal and mixed neuronal–glial tumors are thought to arise from neuroepithelial cells. According to the 2007 WHO classification,\\u000a this group of tumors comprises ganglioglioma and gangliocytoma, desmoplastic infantile astrocytoma (DIA) and ganglioglioma,\\u000a dys-plastic cerebellar gangliocytoma (Lhermitte–Duclos disease), dysembryoplastic neuroepithelial tumor (DNT), central neurocytoma,\\u000a cerebellar liponeurocytoma (CLN), paraganglioma of the cauda equina (PCE), and the more recently recognized subtypes papillary\\u000a glion-euronal

Matthias Simon; Rudolf A. Kristof; Johannes Schramm

192

Hypostase, embryonic sac and endosperm in Anethum graveolens L., and in various families.  

PubMed

The presence of pyriform hypostase tissue was investigated before double fertilization till the fusion of free endosperm nuclei in the embryonic sac of A. graveolens. Hypostase a glandular tissue, can secrete its cell contents into the embryonic sac during the development of free endosperm nuclei. Of 78 randomly selected families, 19 display different numbers of species with hypostase. In 15 of these families the hypostase is present together with the Polygonum type of embryonic sac and nuclear type of endosperm. PMID:757097

Szujkó-Lacza, J

1978-01-01

193

Numerical Simulations of Unsteady Shock Wave Interactions Using SaC and Fortran90  

Microsoft Academic Search

This paper briefly introduces SaC: a data-parallel language with an imperative feel but side-effect free and declarative. The experiences of porting a simulation\\u000a of unsteady shock waves in the Euler system from Fortran to SaC are reported. Both the SaC and Fortran code was run on a 16-core AMD machine. We demonstrate scalability and performance of our approach by comparison

Daniel Rolls; Carl Joslin; Alexei Kudryavtsev; Sven-bodo Scholz; Alexander V. Shafarenko

2009-01-01

194

[Pseudomyxoma peritonei spread into the right inguinal hernia sac--a case report].  

PubMed

Pseudomyxoma peritonei (PMP) is a rare, progressive disease of unknown origin. The incidence is estimated at about 1-2/100,000,000 per year. The primary tumor site is usually discovered in the appendix or- in case of women--in ovaries, appearing as tumors of low malignancy. Making an accurate diagnosis causes difficulties--symptoms tend to be misleading, suggesting more frequent pathologies of the abdominal cavity. It is also not rare that the patient is for a long time asymptomatic. We present a case of a 68-year-old patient of the Surgical Oncology Department treated for pseudomyxoma peritonei, diagnosed incidentally at the time of clinical examination for the reasons of chronic hypertension. The symptoms reported by the patient did not suggest any neoplastic process of the peritoneal cavity. Systemic chemotherapy of two paths (a total number of 10 cycles) did not result and at the time of post-treatment control, due to no response to standard chemotherapy, it was decided to administer chemotherapy intraperitoneally in hyperthermia (HIPEC). During the operation, peritoneal cytoreduction prior to the scheduled HIPEC was performed; the right-sided inguinal hernia was repaired. Within the hernia sac the implanted myxoid cells were found, their presence inside was probably the main reason of clinical manifestation of the disease. PMID:24340893

Cichon, Paulina; Drucis, Kamil; Kakol, Michal; Jastrzebski, Tomasz; Polec, Tomasz

2013-10-01

195

Pediatric malignant germ cell tumors show characteristic transcriptome profiles.  

PubMed

Malignant germ cell tumors (GCT) of childhood are rare and heterogeneous neoplasms thought to arise from primordial germ cells. They vary substantially in their natural history and show important clinical differences from their adult counterparts. To address the biological basis for these observations, we have undertaken a comprehensive analysis of global gene expression patterns in pediatric malignant GCTs and compared these findings with published data on adult testicular GCTs (TGCT). Our study included 27 primary tumors and assessed the principal malignant histologic types of pediatric GCT, yolk sac tumor (YST; n = 18), and seminoma (n = 9). Analysis of Affymetrix U133A GeneChip data was performed using the statistical software environment R, including gene set enrichment analysis, with cross-validation at the RNA and protein level. Unsupervised analysis showed complete separation of YSTs and seminomas by global gene expression profiles and identified a robust set of 657 discriminatory transcripts. There was no segregation of tumors of the same histology arising at different sites or at different ages within the pediatric range. In contrast, there was segregation of pediatric malignant GCTs and adult malignant TGCTs, most notably for the YSTs. The pediatric seminomas were significantly enriched for genes associated with the self-renewing pluripotent phenotype, whereas the pediatric YSTs were significantly enriched for genes associated with a differentiation and proliferation phenotype. We conclude that histologic type is the key discriminator in pediatric malignant GCTs and that the observed clinical differences between malignant GCTs of children and adults are mirrored by significant differences in global gene expression. PMID:18519683

Palmer, Roger D; Barbosa-Morais, Nuno L; Gooding, Emma L; Muralidhar, Balaji; Thornton, Claire M; Pett, Mark R; Roberts, Ian; Schneider, Dominik T; Thorne, Natalie; Tavaré, Simon; Nicholson, James C; Coleman, Nicholas

2008-06-01

196

Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells  

PubMed Central

Background Prostate apoptosis response-4 (Par-4) is a tumor-suppressor protein that selectively activates and induces apoptosis in cancer cells, but not in normal cells. The cancer specific pro-apoptotic function of Par-4 is encoded in its centrally located SAC (Selective for Apoptosis induction in Cancer cells) domain (amino acids 137–195). The SAC domain itself is capable of nuclear entry, caspase activation, inhibition of NF-?B activity, and induction of apoptosis in cancer cells. However, the precise mechanism(s) of how the SAC domain is released from Par-4, in response to apoptotic stimulation, is not well explored. Results In this study, we demonstrate for the first time that sphingosine (SPH), a member of the sphingolipid family, induces caspase-dependant cleavage of Par-4, leading to the release of SAC domain containing fragment from it. Par-4 is cleaved at the EEPD131G site on incubation with caspase-3 in vitro, and by treating cells with several anti-cancer agents. The caspase-3 mediated cleavage of Par-4 is blocked by addition of the pan-caspase inhibitor z-VAD-fmk, caspase-3 specific inhibitor Ac-DEVD-CHO, and by introduction of alanine substitution for D131 residue. Moreover, suppression of SPH-induced Akt dephosphorylation also abrogated the caspase dependant cleavage of Par-4. Conclusion Evidence provided here shows that Par-4 is cleaved by caspase-3 during SPH-induced apoptosis. Cleavage of Par-4 leads to the generation of SAC domain containing fragment which may possibly be essential and sufficient to induce or augment apoptosis in cancer cells.

2013-01-01

197

The PIKfyve–ArPIKfyve–Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines  

SciTech Connect

Highlights: •We assess PAS complex proteins and phosphoinositide levels in breast cancer cells. •Sac3 and ArPIKfyve are markedly elevated in triple-negative breast cancer cells. •Sac3 silencing inhibits proliferation in triple-negative breast cancer cell lines. •Phosphoinositide profiles are altered in breast cancer cells. •This is the first evidence linking high Sac3 with breast cancer cell proliferation. -- Abstract: The phosphoinositide 5-kinase PIKfyve and 5-phosphatase Sac3 are scaffolded by ArPIKfyve in the PIKfyve–ArPIKfyve–Sac3 (PAS) regulatory complex to trigger a unique loop of PtdIns3P–PtdIns(3,5)P{sub 2} synthesis and turnover. Whereas the metabolizing enzymes of the other 3-phosphoinositides have already been implicated in breast cancer, the role of the PAS proteins and the PtdIns3P–PtdIns(3,5)P{sub 2} conversion is unknown. To begin elucidating their roles, in this study we monitored the endogenous levels of the PAS complex proteins in cell lines derived from hormone-receptor positive (MCF7 and T47D) or triple-negative breast cancers (TNBC) (BT20, BT549 and MDA-MB-231) as well as in MCF10A cells derived from non-tumorigenic mastectomy. We report profound upregulation of Sac3 and ArPIKfyve in the triple negative vs. hormone-sensitive breast cancer or non-tumorigenic cells, with BT cell lines showing the highest levels. siRNA-mediated knockdown of Sac3, but not that of PIKfyve, significantly inhibited proliferation of BT20 and BT549 cells. In these cells, knockdown of ArPIKfyve had only a minor effect, consistent with a primary role for Sac3 in TNBC cell proliferation. Intriguingly, steady-state levels of PtdIns(3,5)P{sub 2} in BT20 and T47D cells were similar despite the 6-fold difference in Sac3 levels between these cell lines. However, steady-state levels of PtdIns3P and PtdIns5P, both regulated by the PAS complex, were significantly reduced in BT20 vs. T47D or MCF10A cell lines, consistent with elevated Sac3 affecting directly or indirectly the homeostasis of these lipids in TNBC. Together, our results uncover an unexpected role for Sac3 phosphatase in TNBC cell proliferation. Database analyses, discussed herein, reinforce the involvement of Sac3 in breast cancer pathogenesis.

Ikonomov, Ognian C., E-mail: oikonomo@med.wayne.edu; Filios, Catherine, E-mail: cfilios@med.wayne.edu; Sbrissa, Diego, E-mail: dsbrissa@med.wayne.edu; Chen, Xuequn, E-mail: xchen@med.wayne.edu; Shisheva, Assia, E-mail: ashishev@med.wayne.edu

2013-10-18

198

Cytologically atypical anal sac adenocarcinoma in a dog.  

PubMed

A 10-year-old intact female Shetland Sheepdog with tenesmus had a subcutaneous mass at the left ventral aspect of the anus. On cytologic examination, 2 types of cells were observed. Most of the cells were oval to polygonal and had elliptical or elongate nuclei and a moderate amount of pale to basophilic cytoplasm. The remaining cells had round to oval nuclei and pale to basophilic cytoplasm. Cells of both types were loosely adhered to each other and were arranged in rosette-like structures. Both neoplastic cell types had fine homogenous chromatin and either a small indistinct nucleolus or no visible nucleolus. Mild anisokaryosis and anisocytosis were observed. Histologically, the mass consists of glandular structures formed by cuboidal cells admixed with bundles of spindle cells. Eosinophilic PAS- and Alcian blue-positive secretory material was found in the center of some glandular structures. Both neoplastic cell types had positive staining with paradoxical concanavalin A and expressed cytokeratin, but not vimentin, S-100, ?-smooth muscle actin, or desmin. Based on location and histologic and immunohistochemical features, the final diagnosis was adenocarcinoma of the apocrine gland of the anal sac, which should be included as a cytologic differential diagnosis when spindle cells and typical epithelial cells are observed in masses in the region of the anal sac of dogs. PMID:22551298

Sakai, Hiroki; Murakami, Mami; Mishima, Hiroyuki; Hoshino, Yuki; Mori, Takashi; Maruo, Kohji; Yanai, Tokuma

2012-06-01

199

Ultrastructural evaluation of adenocarcinomas derived from apocrine glands of the anal sac associated with hypercalcemia in dogs.  

PubMed Central

Adenocarcinomas derived from apocrine glands of the anal sac and associated with persistent hypercalcemia in dogs were composed of tumor cells with numerous profiles of rough endoplasmic reticulum, clusters of free ribosomes, and a prominent Golgi apparatus. Neoplastic cells contained microtubules, microfilaments, tonofibrils, and had two types of electron-dense granules. Large lysosomelike dense bodies ranged from 0.6 to 2.2 microns in diameter and had a poorly delineated limiting membrane. Small granules (150-400 nm in diameter) had a sharply delineated limiting membrane with a narrow submembranous space and a homogeneous dense core. These smaller granules usually were located near the apexes of neoplastic cells, whereas the larger granules were situated near the base of cells. Apocrine cells in glands of the anal sac from control dogs that were in the secretory phase were columnar and had large dilated profiles of rough endoplasmic reticulum. Membranes of the endoplasmic reticulum fused with the plasmalemma and appeared to secrete their product directly into the lumens of acini, characteristic of merocrine secretion. Apical blebs of electron-lucent cytoplasm pinched off from nonneoplastic aprocine cells and were released into glandular lumens. Similar electron-lucent cytoplasmic blebs were present at the apexes of tumor cells. Myoepithelial cells were present between the epithelial cells and basement membrane in normal apocrine glands and were absent in neoplasms derived from these glands. Identification of the contents of the secretory-like granules in tumor cells and characterization of the hypercalcemic factor in the plasma or tumor tissue from dogs with this syndrome will help explain the pathogenesis of hypercalcemia associated with malignancy in animals and man. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11

Meuten, D. J.; Capen, C. C.; Kociba, G. J.; Chew, D. J.; Cooper, B. J.

1982-01-01

200

Low-grade fibromyxoid sarcoma arising in the big toe.  

PubMed

Low-grade fibromyxoid sarcoma (LGFMS) is a rare tumor. Reported herein is a case of LGFMS arising in the big toe. The patient was a 58-year-old man who underwent excision of the tumor. The tumor was well-demarcated. Histologically, there were proliferating spindle-shaped tumor cells arranged in a whorled growth pattern, and the stroma showed hyalinized collagen bundles and a myxoid matrix. Nuclear mitotic figures were conspicuous in part. A large rosette-like structure with hyalinized stroma was found, which is characteristic of LGFMS. The differential diagnosis included tumor occurrence in adults; tending to arise in distal extremities; and having bland fibromyxoid histological features, such as fibroma of tendon sheath, low-grade myxofibrosarcoma and acral myxoinflammatory fibroblastic sarcoma. It was not possible to detect the FUS/CREB3L2 and FUS/CREB3L1 fusion genes from the formalin-fixed and paraffin-embedded tissue, although the histological features of the present case were typical of LGFMS. LGFMS may become more common with time, and unique cases may accumulate. PMID:16287497

Kusumi, Tomomi; Nishikawa, Shinji; Tanaka, Masanori; Ogawa, Taro; Jin, Hiromichi; Sato, Fuyuki; Toh, Satoshi; Hasegawa, Tadashi; Kijima, Hiroshi

2005-12-01

201

Proposed Education Guidelines and Procedures: Sac and Fox Nation of Oklahoma.  

ERIC Educational Resources Information Center

These educational guidelines and procedures were developed after extensive review of current education programs for the Sac and Fox Nations of Oklahoma. The guidelines, prepared by a committee of local educators appointed by a tribal business committee, examined the anticipated needs for future generations of the Sac and Fox people. The document…

Sac and Fox Nation, OK. Education Committee.

202

The black lacrimal sac: a clinicopathological correlation of a malignant melanoma with anterior lacrimal crest infiltration.  

PubMed

Primary lacrimal sac melanoma is an extremely rare clinical entity with fewer than 25 cases reported in the literature. We present a well-documented case of lacrimal sac melanoma with anterior lacrimal crest infiltration and discuss the clinical, radiological and histopathological features along with surgical challenges and treatment. PMID:23456510

Pujari, Aditi; Ali, Mohammad Javed; Mulay, Kaustubh; Naik, Milind N; Honavar, Santosh G

2014-02-01

203

Sac1, a putative regulator that is critical for survival of Chlamydomonas reinhardtii during sulfur deprivation.  

PubMed Central

The sac1 mutant of Chlamydomonas reinhardtii is aberrant in most of the normal responses to sulfur limitation; it cannot synthesize arylsulfatase, does not take up sulfate as rapidly as wild-type cells, and does not synthesize periplasmic proteins that normally accumulate during sulfur-limited growth. Here, we show that the sac1 mutant dies much more rapidly than wild-type cells during sulfur deprivation; this emphasizes the vital role of the acclimation process. The loss of viability of the sac1 mutant during sulfur deprivation is only observed in the light and is mostly inhibited by DCMU. During sulfur-stress, wild-type cells, but not the sac1 mutant, downregulate photosynthesis. Thus, death of the sac1 mutant during sulfur deprivation is probably a consequence of its inability to downregulate photosynthesis. Furthermore, since SAC1 is necessary for the downregulation of photosynthesis, the process must be highly controlled and not simply the result of a general decrease in protein synthesis due to sulfur limitation. Genomic and cDNA copies of the SAC1 gene have been cloned. The deduced amino acid sequence of Sac1 is similar to an Escherichia coli gene that may involved in the response of E.coli to nutrient deprivation. Images

Davies, J P; Yildiz, F H; Grossman, A

1996-01-01

204

74. SAC control center addition sect 9top three floors, first ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

74. SAC control center addition sect 9-top three floors, first floor plan, drawing number AS-BLT.AW30-02-03, dated May, 1958 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

205

84. SAC control center addition sect. 9top three floors elevations, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

84. SAC control center addition sect. 9-top three floors elevations, drawing number AS-BLT.AW30-02-03, dated 10 May, 1958 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

206

Finite Element Analysis of Stresses Developed in the Blood Sac of a Left Ventricular Assist Device  

PubMed Central

The goal of this research is to develop a 3D finite element (FE) model of a left ventricular assist device (LVAD) to predict stresses in the blood sac. The hyperelastic stress-strain curves for the segmented poly(ether polyurethane urea) blood sac were determined in both tension and compression using a servo-hydraulic testing system at various strain rates. Over the range of strain rates studied, the sac was not strain rate sensitive, however the material response was different for tension versus compression. The experimental tension and compression properties were used in a FE model that consisted of the pusher plate, blood sac and pump case. A quasi-static analysis was used to allow for nonlinearities due to contact and material deformation. The 3D FE model showed that blood sac stresses are not adversely affected by the location of the inlet and outlet ports of the device and that over the systolic ejection phase of the simulation the prediction of blood sac stresses from the full 3D model and an axisymmetric model are the same. Minimizing stresses in the blood sac will increase the longevity of the blood sac in vivo.

Haut Donahue, T. L.; Dehlin, W.; Gillespie, J.; Weiss, W.J.; Rosenberg, G.

2009-01-01

207

Mammalian laryngseal air sacs add variability to the vocal tract impedance: Physical and computational modeling  

PubMed Central

Cavities branching off the main vocal tract are ubiquitous in nonhumans. Mammalian air sacs exist in human relatives, including all four great apes, but only a substantially reduced version exists in humans. The present paper focuses on acoustical functions of the air sacs. The hypotheses are investigated on whether the air sacs affect amplitude of utterances and?or position of formants. A multilayer synthetic model of the vocal folds coupled with a vocal tract model was utilized. As an air sac model, four configurations were considered: open and closed uniform tube-like side branches, a rigid cavity, and an inflatable cavity. Results suggest that some air sac configurations can enhance the sound level. Furthermore, an air sac model introduces one or more additional resonance frequencies, shifting formants of the main vocal tract to some extent but not as strongly as previously suggested. In addition, dynamic range of vocalization can be extended by the air sacs. A new finding is also an increased variability of the vocal tract impedance, leading to strong nonlinear source-filter interaction effects. The experiments demonstrated that air-sac-like structures can destabilize the sound source. The results were validated by a transmission line computational model.

Riede, Tobias; Tokuda, Isao T.; Munger, Jacob B.; Thomson, Scott L.

2008-01-01

208

Infestation of the lacrimal sac by Rhinosporidium seeberi: A clinicopathological case report  

PubMed Central

Rhinosporidium seeberi, till recently known as a fungus, has been reclassified as a protistan parasite. It infects humans and many animal species. The authors describe a rare case of oculosporidiosis with involvement of the lacrimal sac exhibiting features of idiopathic orbital inflammatory disease in a young male patient. Clinical features, pathophysiology, and management of lacrimal sac rhinosporidiosis have been discussed.

Mukherjee, Bipasha; Mohan, Ashwin; Sumathi, V; Biswas, Jyotirmay

2013-01-01

209

Infestation of the lacrimal sac by Rhinosporidium seeberi: a clinicopathological case report.  

PubMed

Rhinosporidium seeberi , till recently known as a fungus, has been reclassified as a protistan parasite. It infects humans and many animal species. The authors describe a rare case of oculosporidiosis with involvement of the lacrimal sac exhibiting features of idiopathic orbital inflammatory disease in a young male patient. Clinical features, pathophysiology, and management of lacrimal sac rhinosporidiosis have been discussed. PMID:24212311

Mukherjee, Bipasha; Mohan, Ashwin; Sumathi, V; Biswas, Jyotirmay

2013-10-01

210

An Isolated Venous Sac as a Novel Site for Cell Therapy in Diabetes Mellitus  

PubMed Central

Background Transplanting pancreatic islets is of significant interest for type 1 diabetes mellitus. After intraportal injection of islets, inferior engraftment and eventual loss of transplanted islets constitute major limitations. Therefore, alternative approaches will be helpful. Here, we evaluated in animals whether an isolated venous sac would support survival of transplanted islets, along with correction of hyperglycemia. Methods Pancreatic islets isolated from adult Lewis rats were transplanted either into an isolated venous sac made from lumbar vein or into the portal vein of syngeneic rats. The integrity and vascular organization of the venous sac was determined by studies of the local microcirculation. The engraftment, survival, and function of transplanted islets were analyzed by histology, including endocrine function in situ and by glycemic control in rats with streptozotocin-induced diabetes. Results Transplanted islets showed normal morphology with insulin expression in isolated venous sac during the long term. Transplanted islets received blood supply from vasa vasorum and had access to drainage through venous tributaries in the venous sac. This resulted in restoration of euglycemia in diabetic rats. Removal of islet graft-bearing venous sac in diabetic rats led to recurrence of hyperglycemia. By contrast, euglycemia was not restored in rats treated by intraportal transplantation of islets. Conclusions We demonstrated that pancreatic islets successfully engrafted and functioned in the isolated venous sac with ability to restore euglycemia in diabetic rats. Therefore, the isolated venous sac offers a new site for transplantation of pancreatic islets. This would be clinically beneficial as an alternative to intrahepatic islet transplantation.

Kakabadze, Zurab; Shanava, Koba; Ricordi, Camillo; Shapiro, A.M. James; Gupta, Sanjeev; Berishvili, Ekaterine

2013-01-01

211

Strategy of Combined Treatment of Germ Cell Tumors  

Microsoft Academic Search

The histopathological entity ‘germ cell tumor’ (GCT) encompasses a number of histological subtypes. Pineal GCTs can be grossly divided into three categories: those with a good, intermediate, and poor prognostic. Germinoma and mature teratoma are curable and classified into the good prognostic group, whereas embryonal carcinoma, yolk sac tumor, and other highly malignant neoplasms leave patients with a dismal prognosis.

Yutaka Sawamura

2009-01-01

212

Endometriosis within a left-sided inguinal hernia sac  

PubMed Central

Endometriosis is a common gynecologic disorder wherein ectopic endometrial glands and stroma are found at extrauterine sites. Extrapelvic endometriosis is a well-documented, yet rare, disease entity that can affect almost any organ system. Inguinal endometriosis is an extremely rare disease entity characterized by tender inguinal swelling. Here we report a case of a sudden-onset and acutely painful left inguinal hernia with concordant endometriosis. A review of the literature is presented. The presence of isolated endometriosis contained within a left-sided inguinal hernia sac has, to our knowledge, never been reported. Often diagnosed incidentally or on histologic examination, general surgeons should consider inguinal endometriosis in the differential diagnosis of inguinal masses, even in the absence of catamenial symptoms. Surgical excision, with gynecologic follow-up, is locally curative and the treatment of choice for inguinal endometriosis.

Albutt, Katherine; Glass, Charity; Odom, Stephen; Gupta, Alok

2014-01-01

213

Clearance of chlamydial elementary bodies from the conjunctival sac  

SciTech Connect

The rate of disappearance of inactivated Chlamydia trachomatis elementary body (EB) preparations from the conjunctival sac was studied in monkeys. Direct fluorescent antibody (DFA) cytology showed that the majority of EB had been cleared from the eye within 24 hr of the inoculation of 1 X 10(6) inactivated EB, although small numbers of EB could be detected for up to 144 hr. The rate of clearance in normal and ocular immune animals did not differ, and formalin-killed and UV-inactivated EBs disappeared at a comparable rate. These studies suggest that chlamydial EB are cleared relatively quickly from the eye and support the notion that EBs detected by DFA cytology indicate the presence of current infection.

Taylor, H.R.; Velez, V.L.

1987-07-01

214

Ground water in the Cul-de-Sac Plain, Haiti  

USGS Publications Warehouse

The Cul-de-Sac Plain is perhaps the most important agricultural area in Haiti because of its nearness and accessibility to Port-au-Prince, the nation's capital, metropolis, and principal seaport. Most of the agricultural produce consumed in Port-au-Prince as well as a considerable part of that exported from Haiti is grown in the plain. Because of variable and poorly distributed rainfall, high temperature, and high evaporation, semiarid climatic conditions prevail in the plain. Irrigation is, therefore, necessary for successful farming. There are no regulatory or storage facilities on the streams that enter the plain, but the mean and low-water stream flow and the discharge of springs are almost entirely appropriated for irrigation. Ground water has been utilized for irrigation to an increasing extent by the Haitian American Sugar Company, which has put down about 100 wells in the plain since 1919. Outside the existing irrigated areas of the plain are large tracts of potentially irrigable land that are uncultivated and agriculturally unproductive for lack of water. The object of the present study was to determine the possibilities of bringing these lands into cultivation by irrigation from wells. This study was part of a larger program of the Food Supply Division, Institute of Inter-American Affairs, to increase the production of food in Haiti. From September through November 1948 the senior author, a member of the U. S. Geological Survey, spent three months in the field in an investigation of the geology and ground-water resources of the Cul-de-Sac Plain. He was ably assisted by Mr. Rémy C. Lemoine, Haitian engineer-geologist, employed by the Food Supply Division. The field work included principally the geologic mapping of' the plain and the adjacent mountain borders, a ground-water inventory of existing wells and springs, and a general evaluation of significant geologic and hydrologic features.

Taylor, George C., Jr.; Lemoine, Rémy C.

1949-01-01

215

pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC)  

PubMed Central

Soluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3?, 5? monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO?3) ions. In living cells, HCO?3 ions are in nearly instantaneous equilibrium with carbon dioxide (CO2) and pH due to the ubiquitous presence of carbonic anhydrases. Numerous biological processes are regulated by CO2, HCO?3, and/or pH, and in a number of these, sAC has been shown to function as a physiological CO2/HCO3/pH sensor. In this review, we detail the known pH sensing functions of sAC, and we discuss two highly-studied, pH-dependent pathways in which sAC might play a role.

Rahman, Nawreen; Buck, Jochen; Levin, Lonny R.

2013-01-01

216

Development of the endolymphatic sac in chick embryos, with reference to the degradation of otoconia  

NASA Technical Reports Server (NTRS)

The endolymphatic sac of chick embryos (from embryonic day 7 to 1-day-old chicks) was studied light- and electron-microscopically. At stage 30-31 (embryonic day 7-7.5), the epithelial cells of the endolymphatic sac were cuboidal to columnar in shape. Microvilli were relatively well developed. The intercellular space was wide. In the endolymphatic space of the endolymphatic sac, varying shapes and sizes of otoconia-like bodies were often observed. Intracytoplasmic phagosomes containing these bodies were rarely found. After stage 37 (embryonic day 11), otoconia-like bodies in the endolymphatic sac decreased in number and size. They were almost the same as the otoconia in the macular organs, ultrastructurally. These findings indicate that the endolymphatic sac of the chick embryos may possess the function of otoconial degradation and removal of calcium from otoconia.

Yoshihara, T.; Kaname, H.; Narita, N.; Ishii, T.; Igarashi, M.; Fermin, C. D.

1992-01-01

217

[Unusual clinical presentation of hepatic yolk sac tumour in periappendical region. A case report and review of the literature].  

PubMed

Primary hepatic yolk sac tumour (YST) is a very rare neoplasm. The authors present a case of a 20-year-old woman with fever and pain in the epigastrium, clinically resembling acute appendicitis along with high levels of serum alpha-fetoprotein. From laparoscopic appendectomy there was bioptically verified a diagnosis of YST. Consequently, there was discovered a tumor in the liver and the patient underwent right hemihepatectomy, hemicolectomy and ovariectomy, from which the YST was disclosed in the liver and in the coecum with spread into regional lymph nodes. While the gonadal, mediastinal and central nervous system origin of the YST was excluded, the diagnosis of the primary hepatic YST could have been established. The exact etiology of primary hepatic YST is still unclear. It has been suggested that these YSTs might originate from the germ cells that escaped during migration course from the yolk sac to the genital ridge during embryogenesis with subsequent malignant transformation or from persistent pluripotent embryonic cells in the liver, which escaped from the influence of differentiation during embryogenesis. This tumour is aggressive with ability to spread into distant sites, where it can lead to the first clinical presentation. PMID:20301839

Kajo, K; Macháleková, K; Laca, L

2009-10-01

218

Multiple ectopic hepatocellular carcinomas arising in the abdominal cavity.  

PubMed

Ectopic hepatocellular carcinoma (HCC) is a very rare clinical entity that is defined as HCC arising from extrahepatic liver tissue. This report presents a case of ectopic multiple HCC arising in the abdominal cavity. A 42-year-old otherwise healthy male presented with liver dysfunction at a general health checkup. Both HCV antibody and hepatitis B surface antigen were negative. Laboratory examination showed elevations in serum alpha-fetoprotein and PIVKA-II. Ultrasonography and computed tomography revealed multiple nodular lesions in the abdominal cavity with ascites without a possible primary tumor. Exploratory laparoscopy was performed, which revealed bloody ascites and multiple brown nodular tumors measuring approximately 10 mm in size that were disseminated on the perineum and mesentery. A postoperative PET-CT scan was performed but it did not reveal any evidence of a tumor in the liver. The tumors resected from the peritoneum were diagnosed as HCC. The present case of HCC was thought to have possibly developed from ectopic liver on the peritoneum or mesentery. PMID:23139654

Miyake, Toru; Hoshino, Seiichiro; Yoshida, Yoichiro; Aisu, Naoya; Tanimura, Syu; Hisano, Satoshi; Kuno, Nobuaki; Sohda, Tetsuro; Sakisaka, Shotaro; Yamashita, Yuichi

2012-09-01

219

Multiple Ectopic Hepatocellular Carcinomas Arising in the Abdominal Cavity  

PubMed Central

Ectopic hepatocellular carcinoma (HCC) is a very rare clinical entity that is defined as HCC arising from extrahepatic liver tissue. This report presents a case of ectopic multiple HCC arising in the abdominal cavity. A 42-year-old otherwise healthy male presented with liver dysfunction at a general health checkup. Both HCV antibody and hepatitis B surface antigen were negative. Laboratory examination showed elevations in serum alpha-fetoprotein and PIVKA-II. Ultrasonography and computed tomography revealed multiple nodular lesions in the abdominal cavity with ascites without a possible primary tumor. Exploratory laparoscopy was performed, which revealed bloody ascites and multiple brown nodular tumors measuring approximately 10 mm in size that were disseminated on the perineum and mesentery. A postoperative PET-CT scan was performed but it did not reveal any evidence of a tumor in the liver. The tumors resected from the peritoneum were diagnosed as HCC. The present case of HCC was thought to have possibly developed from ectopic liver on the peritoneum or mesentery.

Miyake, Toru; Hoshino, Seiichiro; Yoshida, Yoichiro; Aisu, Naoya; Tanimura, Syu; Hisano, Satoshi; Kuno, Nobuaki; Sohda, Tetsuro; Sakisaka, Shotaro; Yamashita, Yuichi

2012-01-01

220

Retrorectal Tumors  

PubMed Central

Tumors that arise in the retrorectal (presacral) space are uncommon lesions that present with nonspecific signs and symptoms, which lead to difficult diagnoses. For complete evaluation of the lesion, cross-sectional imaging is required to determine the extent of resection and the appropriate surgical approach. Surgical removal leads to favorable outcomes for patients with benign purely cystic retrorectal tumors. Preoperative tissue diagnosis with transperineal and transsacral biopsies of solid or heterogeneous cystic lesions, are essential to determine the necessity of neoadjuvant therapy, which may decrease local recurrence after surgery and avoid an unnecessary delay in systemic therapy.

Neale, Jeffrey A.

2011-01-01

221

The fate of heterotopic isografts and allografts of mouse yolk sac epithelium.  

PubMed Central

As a contribution to the problem of the immunological privilege of the fetus it was decided to investigate the fate of yolk sac grafts in mice. Ten-day post-coitum mouse visceral yolk sac was transplanted to a dermal tunnel in the flank of isogeneic animals. In this site the yolk sac was capable of surviving for at least 15 days past the normal duration of pregnancy. Yolk sac was transplanted to a similar site in allogeneic animals and was found to be destroyed by an immunological reaction within 13 days. Orthotopic skin grafts between the same strains of mice used in the yolk sac transplantation were rejected in first-set fashion within 13 days. A limited series of host animals, previously sensitized by visceral yolk sac, rejected orthotopic skin grafts in second-set fashion. These findings indicate that the cells of the visceral yolk sac in the mouse contain transplantation antigens. Possible reasons why such antigens do not lead to fetal rejection during pregnancy are considered. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6

Andrew, T A; Coles, J S; Scothorne, R J

1975-01-01

222

Guidance in vitro of the pollen tube to the naked embryo sac of torenia fournieri  

PubMed Central

The precise guidance of the pollen tube to the embryo sac is critical to the successful sexual reproduction of flowering plants. We demonstrate here the guidance of the pollen tube to the embryo sac in vitro by using the naked embryo sac of Torenia fournieri, which protrudes from the micropyle of the ovule. We developed a medium for culture of both the ovule and the pollen tube of T. fournieri and cocultivated them in a thin layer of solid medium. Although pollen tubes that had germinated in vitro passed naked embryo sacs, some pollen tubes that grew semi-in vitro through a cut style arrived precisely at the site of entry into the embryo sac, namely, the filiform apparatus of the synergids. When pollen tubes were unable to enter the embryo sac, they continuously grew toward the same filiform apparatus, forming narrow coils. Pollen tubes selectively arrived at complete, unfertilized embryo sacs but did not arrive at those of heat-treated ovules or those with disrupted synergids. These results convincingly demonstrate that pollen tubes are specifically attracted to the region of the filiform apparatus of living synergids in vitro.

Higashiyama, T; Kuroiwa, H; Kawano, S; Kuroiwa, T

1998-01-01

223

Osteosarcoma Tumor Thrombus  

PubMed Central

Tumor thrombus arising from osteosarcoma is rare. We report the case of a 20-year-old man with proximal humerus osteosarcoma, accompanied by an extensive intravascular tumor thrombus extending into the heart. Our review of the literature found 14 previous reports on osteosarcoma with tumor thrombus. The combination of positron emission tomography and computed tomography is very useful in differentiating tumor thrombus from vascular thrombus, thereby avoiding unnecessary anticoagulation therapy. This same imaging combination can also be used to evaluate the response to treatment. Surgical resection of the tumor thrombus is highly recommended. The effect of tumor thrombus on survival is still unknown.

Navalkele, Pournima; Jones, Sarah M.; Jones, Jason K.; Salazar, Jorge D.; Toy, Patrick C.; Iyer, Rathi V.; Herrington, Betty

2013-01-01

224

An unusual feature of yolk sac placentation in Necromys lasiurus (Rodentia, Cricetidae, Sigmodontinae).  

PubMed

We studied the development of the inverted yolk sac in a New World rodent, Necromys lasiurus during early placentation. Ten implantation sites were investigated by means of histology, immunohistochemistry and electron microscopy. The yolk sac was villous near its attachment to the placenta. Elsewhere it was non-villous and closely attached to the uterus. The uterine glands were shallow and wide mouthed. They were associated with vessels and filled with secretion, suggesting the release of histotroph. This feature was absent at later stages. The intimate association of the yolk sac with specialized glandular regions of the uterus may represent a derived character condition of Necromys and/or sigmodont rodents. PMID:22541609

Favaron, P O; Carter, A M; Mess, A M; de Oliveira, M F; Miglino, M A

2012-07-01

225

Desmoplastic fibroma arising in the distal phalanx of the great toe: a case report.  

PubMed

Desmoplastic fibroma (DF) of the bone is a rare locally aggressive tumor usually occurring in adolescents and young adults. These tumors most commonly occur in the mandibles and metaphyses of long bones but are extremely rare in small bones, often resulting in diagnostic problems. The occurrence of these tumors in the foot is especially limited. We report the clinical, radiographic, and histologic features of DF arising in the distal phalanx of the great toe and a review of the published data. PMID:24238967

Koba, Takeshi; Susa, Michiro; Nakayama, Robert; Watanabe, Itsuo; Horiuchi, Keisuke; Mukai, Makio; Yabe, Hiroo; Toyama, Yoshiaki; Morioka, Hideo

2014-01-01

226

Endodermal Sinus Tumor of Vagina in Infants  

PubMed Central

Abstract Endodermal sinus tumor (or Yolk Sac tumor) of the vagina is a rare malignant germcell tumor which is seen exclusively in children younger than 3 years of age. We report two cases of endodermal sinus tumor of the vagina. In both cases no radiological investigation was done and serum alpha-fetoprotein was elevated. The histopathological examination of both the tumor masses revealed vaginal endodermal sinus tumor. Periodic-acid-Schiff stain with diastase showed diastase resistant hyaline globules. These findings confirmed the diagnosis of endodermal sinus tumor in both cases. Vaginal endodermal sinus tumor is both locally aggressive and capable of metastasis. The serum alpha-fetoprotein level is a useful marker for diagnosis and monitoring the recurrence of vaginal endodermal sinus tumor in infants. Early detection and therapy is important because of its aggressive nature and good response to chemotherapy.

Chauhan, Smita; Nigam, Jitendra Singh; Singh, Pallavi; Misra, Vatsala; Thakur, Brijesh

2013-01-01

227

Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels.  

PubMed

In adult mammals, leukocyte recruitment follows a well-defined cascade of adhesion events enabling leukocytes to leave the circulatory system and transmigrate into tissue. Currently, it is unclear whether leukocyte recruitment proceeds in a similar fashion during fetal development. Considering the fact that the incidence of neonatal sepsis increases dramatically with decreasing gestational age in humans, we hypothesized that leukocyte recruitment may be acquired only late during fetal ontogeny. To test this, we developed a fetal intravital microscopy model in pregnant mice and, using LysEGFP (neutrophil reporter) mice, investigated leukocyte recruitment during fetal development. We show that fetal blood neutrophils acquire the ability to roll and adhere on inflamed yolk sac vessels during late fetal development, whereas at earlier embryonic stages (before day E15), rolling and adhesion were essentially absent. Accordingly, flow chamber experiments showed that fetal EGFP(+) blood cells underwent efficient adhesion only when they were harvested on or after E15. Fluorescence-activated cell sorter analysis on EGFP(+) fetal blood cells revealed that surface expression of CXCR2 and less pronounced P-selectin glycoprotein ligand-1 (PSGL-1) begin to increase only late in fetal life. Taken together, our findings demonstrate that inflammation-induced leukocyte recruitment is ontogenetically regulated and enables efficient neutrophil trafficking only during late fetal life. PMID:23525796

Sperandio, Markus; Quackenbush, Elizabeth J; Sushkova, Natalia; Altstätter, Johannes; Nussbaum, Claudia; Schmid, Stephan; Pruenster, Monika; Kurz, Angela; Margraf, Andreas; Steppner, Alina; Schweiger, Natalie; Borsig, Lubor; Boros, Ildiko; Krajewski, Nele; Genzel-Boroviczeny, Orsolya; Jeschke, Udo; Frommhold, David; von Andrian, Ulrich H

2013-05-23

228

Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels  

PubMed Central

In adult mammals, leukocyte recruitment follows a well-defined cascade of adhesion events enabling leukocytes to leave the circulatory system and transmigrate into tissue. Currently, it is unclear whether leukocyte recruitment proceeds in a similar fashion during fetal development. Considering the fact that the incidence of neonatal sepsis increases dramatically with decreasing gestational age in humans, we hypothesized that leukocyte recruitment may be acquired only late during fetal ontogeny. To test this, we developed a fetal intravital microscopy model in pregnant mice and, using LysEGFP (neutrophil reporter) mice, investigated leukocyte recruitment during fetal development. We show that fetal blood neutrophils acquire the ability to roll and adhere on inflamed yolk sac vessels during late fetal development, whereas at earlier embryonic stages (before day E15), rolling and adhesion were essentially absent. Accordingly, flow chamber experiments showed that fetal EGFP+ blood cells underwent efficient adhesion only when they were harvested on or after E15. Fluorescence-activated cell sorter analysis on EGFP+ fetal blood cells revealed that surface expression of CXCR2 and less pronounced P-selectin glycoprotein ligand-1 (PSGL-1) begin to increase only late in fetal life. Taken together, our findings demonstrate that inflammation-induced leukocyte recruitment is ontogenetically regulated and enables efficient neutrophil trafficking only during late fetal life.

Quackenbush, Elizabeth J.; Sushkova, Natalia; Altstatter, Johannes; Nussbaum, Claudia; Schmid, Stephan; Pruenster, Monika; Kurz, Angela; Margraf, Andreas; Steppner, Alina; Schweiger, Natalie; Borsig, Lubor; Boros, Ildiko; Krajewski, Nele; Genzel-Boroviczeny, Orsolya; Jeschke, Udo; Frommhold, David

2013-01-01

229

Analysis for stress environment in the alveolar sac model  

PubMed Central

Better understanding of alveolar mechanics is very important in order to avoid lung injuries for patients undergoing mechanical ventilation for treatment of respiratory problems. The objective of this study was to investigate the alveolar mechanics for two different alveolar sac models, one based on actual geometry and the other an idealized spherical geometry using coupled fluid-solid computational analysis. Both the models were analyzed through coupled fluid-solid analysis to estimate the parameters such as pressures/velocities and displacements/stresses under mechanical ventilation conditions. The results obtained from the fluid analysis indicate that both the alveolar geometries give similar results for pressures and velocities. However, the results obtained from coupled fluid-solid analysis indicate that the actual alveolar geometry results in smaller displacements in comparison to a spherical alveolar model. This trend is also true for stress/strain between the two models. The results presented indicate that alveolar geometry greatly affects the pressure/velocities as well as displacements and stresses/strains.

Pidaparti, Ramana M.; Burnette, Matthew; Heise, Rebecca L.; Reynolds, Angela

2014-01-01

230

Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function  

PubMed Central

The budding mode of Saccharomyces cerevisiae cell growth demands that a high degree of secretory polarity be established and directed toward the emerging bud. We report here our demonstration that mutations in SAC1, a gene identified by virtue of its allele-specific genetic interactions with yeast actin defects, were also capable of suppressing sec14 lethalities associated with yeast Golgi defects. Moreover, these sac1 suppressor properties also extended to sec6 and sec9 secretory vesicle defects. The genetic data are consistent with the notion that SAC1p modulates both secretory pathway and actin cytoskeleton function. On this basis, we suggest that SAC1p may represent one aspect of the mechanism whereby secretory and cytoskeletal activities are coordinated, so that proper spatial regulation of secretion might be achieved.

1989-01-01

231

Structural changes in the lacrimal sac epithelium and associated lymphoid tissue during experimental dacryocystitis  

PubMed Central

Purpose To examine structural changes in the lacrimal sac epithelium and associated lymphoid tissue of rabbits with experimentally induced dacryocystitis. Methods Experimental dacryocystitis was induced by an inoculation of Staphylococcus aureus into the lacrimal sac. The histological changes of the inflamed lacrimal sac epithelium and associated lymphoid tissue were studied by light and electron microscopy. Results After 1 month, numerous inflammatory cells (CD20-positive B lymphocytes, CD3-positive T lymphocytes, IgA-positive plasma cells, and polymorphonuclear leukocytes) infiltrated the lamina propria and the epithelium overlying the diffuse lymphoid tissue. Three months later, the density of the infiltrated leukocytes was markedly decreased. The epithelial lining overlying the diffuse lymphoid tissue became thicker with numerous secretory granules in the supranuclear regions. Conclusion The lacrimal sac epithelium and associated lymphoid tissue play a major role in the defense mechanism during inflammation. Overproduction of secretory granules after bacterial inoculation could enhance the antimicrobial defense.

Ishikawa, Makoto; Kubo, Masabumi; Maeda, Seiji; Sawada, Yu; Uchio, Eiichi; Yoshitomi, Takeshi

2011-01-01

232

Analysis of Crystal Shield 86 - The First SAC (Strategic Air Command) Innovation Task Force.  

National Technical Information Service (NTIS)

The bestsellers 'In Search of Excellence' and 'A Passion for Excellence' spawned an interest about innovation in large organizations. The Strategic Air Command (SAC) formed an innovation task force called Crystal Shield 86. This innovation project appeare...

J. K. Turnipseed

1987-01-01

233

38 CFR Appendix A to Part 41 - Data Collection Form (Form SF-SAC)  

Code of Federal Regulations, 2013 CFR

...SF-SAC and instructions for its completion may be obtained from the following Web page: http://harvester.census.gov/fac/collect/sfsac_01.pdf . It is also available from the address provided in §...

2013-07-01

234

Evidence for Avian Intrathoracic Air Sacs in a New Predatory Dinosaur from Argentina  

PubMed Central

Background Living birds possess a unique heterogeneous pulmonary system composed of a rigid, dorsally-anchored lung and several compliant air sacs that operate as bellows, driving inspired air through the lung. Evidence from the fossil record for the origin and evolution of this system is extremely limited, because lungs do not fossilize and because the bellow-like air sacs in living birds only rarely penetrate (pneumatize) skeletal bone and thus leave a record of their presence. Methodology/Principal Findings We describe a new predatory dinosaur from Upper Cretaceous rocks in Argentina, Aerosteon riocoloradensis gen. et sp. nov., that exhibits extreme pneumatization of skeletal bone, including pneumatic hollowing of the furcula and ilium. In living birds, these two bones are pneumatized by diverticulae of air sacs (clavicular, abdominal) that are involved in pulmonary ventilation. We also describe several pneumatized gastralia (“stomach ribs”), which suggest that diverticulae of the air sac system were present in surface tissues of the thorax. Conclusions/Significance We present a four-phase model for the evolution of avian air sacs and costosternal-driven lung ventilation based on the known fossil record of theropod dinosaurs and osteological correlates in extant birds: (1)?Phase I—Elaboration of paraxial cervical air sacs in basal theropods no later than the earliest Late Triassic. (2)?Phase II—Differentiation of avian ventilatory air sacs, including both cranial (clavicular air sac) and caudal (abdominal air sac) divisions, in basal tetanurans during the Jurassic. A heterogeneous respiratory tract with compliant air sacs, in turn, suggests the presence of rigid, dorsally attached lungs with flow-through ventilation. (3)?Phase III—Evolution of a primitive costosternal pump in maniraptoriform theropods before the close of the Jurassic. (4)?Phase IV—Evolution of an advanced costosternal pump in maniraptoran theropods before the close of the Jurassic. In addition, we conclude: (5)?The advent of avian unidirectional lung ventilation is not possible to pinpoint, as osteological correlates have yet to be identified for uni- or bidirectional lung ventilation. (6)?The origin and evolution of avian air sacs may have been driven by one or more of the following three factors: flow-through lung ventilation, locomotory balance, and/or thermal regulation.

Sereno, Paul C.; Martinez, Ricardo N.; Wilson, Jeffrey A.; Varricchio, David J.; Alcober, Oscar A.; Larsson, Hans C. E.

2008-01-01

235

Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment  

ClinicalTrials.gov

Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Metastatic Childhood Soft Tissue Sarcoma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Childhood Visual Pathway Glioma; Unspecified Childhood Solid Tumor, Protocol Specific

2013-09-27

236

Askin's Tumor: A Dual Case Study  

PubMed Central

Askin's tumor is a rare tumor arising from the chest wall. It is a subset of Ewing sarcoma characterized histologically by the presence of small round blue cells. It is a highly malignant tumor with guarded prognosis, which is dependent upon the extension of tumor at the time of diagnosis. A dual paper of Askin's tumors in young boys is being presented here.

Shrestha, Bikash; Kapur, Bhupendra Nath; Karmacharya, Kavita; Kakkar, Sunita; Ghuliani, Ranjit

2011-01-01

237

An investigation of colonization of the conjunctival sac of sheep by bacteria and mycoplasmas.  

PubMed Central

The conjunctival sacs of 100 healthy adult ewes and 20 lambs and 76 adult ewes affected by ovine keratoconjunctivitis (OKC) were examined microbiologically. Branhamella ovis was the only organism regularly isolated from healthy ewes and lambs, Mycoplasma conjunctivae was isolated from the conjunctival sac of nine ewes but its occurrence was not associated with clinical signs of ovine keratoconjunctivitis. Mycoplasma conjunctivae and Branhamella ovis were isolated significantly more often from eyes affected by OKC than from unaffected eyes. Images Fig. 1

Dagnall, G. J.

1994-01-01

238

Deposition of anal-sac secretions by captive wolves (Canis lupus)  

USGS Publications Warehouse

Deposition of anal-sac secretions by captive wolves was investigated by a labelling technique using protein-bound iodine125 and food dye. Wolves deposited secretions on some but not all scats. Adult males, especially the alpha male, deposited anal-sac secretions more frequently while defecating than did females or juveniles. Secretions sometimes also were deposited independently of defecation, suggesting a dual role in communication by these substances.

Asa, C.S.; Peterson, E.K.; Seal, U.S.; Mech, L.D.

1985-01-01

239

Rhinosporidiosis of lacrimal sac: a rare case report from North East India.  

PubMed

Rhinosporidiosis usually affects the mucous membrane of nose and conjunctiva, less frequently lacrimal sac, urethra, and skin. This is a case presentation of rare lacrimal sac rhinosporidiosis for the first time reported from the state of Tripura in North East India. Diagnosis of rhinosporidiosis is usually made by routine histological examination and treatment is surgical excision. It needs follow up as recurrence is common. PMID:23134946

Saha Ray, Manasi; Datta, Abhijit; Sarkar, Phani Kumar

2011-01-01

240

Female Gametophyte Development in Maize: Microtubular Organization and Embryo Sac Polarity.  

PubMed Central

The developmental stages of the maize embryo sac were correlated with the corresponding silk lengths of ear florets in the female inflorescence. The development of embryo sacs in the ovules of spikes occurs in a gradient pattern with the initiation of the embryo sac beginning at the base of the ear and progressing to the top. At the beginning of meiosis, the presence of conspicuous cortical microtubules coincides with the extensive elongation of the megasporocyte. The spindles at metaphase I and II align along the long axis of the megasporocyte leading to the linear alignment of the dyad and tetrad of megaspores. During megagametogenesis, micropylar and chalazal nuclei of the embryo sac undergo synchronized divisions and migration at the second and third mitosis. Radiate perinuclear microtubules are present during the interphase of the second and third mitosis, and inter-sister nuclear microtubules occur at the late four-nucleate embryo sac. The configuration and orientation of the spindles, phragmoplasts, and pairs of nuclei result in precise positioning of the nuclei. The fusion of the polar nuclei and the formation of a microtubule organizing center-like structure in the filiform apparatus occur right after the first division of the antipodal cells. The different patterns of organization of microtubules in the cells of the mature embryo sac reflect their structural adaptations for their future function.

Huang, B. Q.; Sheridan, W. F.

1994-01-01

241

Allergic fungal sinusitis involving the lacrimal sac: a case report and review.  

PubMed

Abstract Background: We report a case of allergic fungal sinusitis (AFS) involving the lacrimal sac and review the current English literature. A literature search for AFS involving the lacrimal sac revealed two reports with only one of the two cases demonstrating histological evidence of fungal elements. This is just the third such case and only the second reported case with histopathologic confirmation of fungal elements by Gomori methenamine silver (GMS) stain. Materials and Methods: A PubMed database search was performed using combinations of the following key words: allergic fungal sinusitis, lacrimal sac, nasolacrimal duct, ophthalmology, epiphora, orbit. A 70-year-old white man with a history of chronic conjunctivitis and nasal polyps presenting with chronic epiphora was found to have dacryostenosis on the left side. A CT scan of the orbits revealed mucoperiosteal thickening completely obliterating the frontal, ethmoid and sphenoid sinuses. Results: A left external dacryocystorhinostomy (DCR) was performed and the lacrimal sac contents were studied histopathologically. Microscopic examination of the lacrimal sac contents disclosed allergic mucin with laminated aggregates of eosinophils in various stages of degeneration, Charcot-Leyden crystals and rare noninvasive fungal hyphae confirming the diagnosis of AFS. Fungal elements stained positively with Gomori methenamine silver stain. Conclusion: Although rarely reported, AFS can affect the lacrimal sac. AFS should be suspected in patients with a history of recurrent refractory sinusitis, recurrent dacryocystitis and nasal polyposis. Early diagnosis is important for adequate treatment and prevention of recurrence. PMID:24832182

Pao, Kristina Y; Yakopson, Vladimir; Flanagan, Joseph C; Eagle, Ralph C

2014-08-01

242

The Ashbya gossypii fimbrin SAC6 is required for fast polarized hyphal tip growth and endocytosis.  

PubMed

Ashbya gossypii has been an ideal system to study filamentous hyphal growth. Previously, we identified a link between polarized hyphal growth, the organization of the actin cytoskeleton and endocytosis with our analysis of the A. gossypii Wiskott-Aldrich Syndrome Protein (WASP)-homolog encoded by the AgWAL1 gene. Here, we studied the role of AgSAC6, encoding a fimbrin in polarized hyphal growth and endocytosis, and based on our functional analysis identified genetic interactions between AgSAC6 and AgWAL1. SAC6 mutants show severely reduced polarized growth. This growth phenotype is temperature dependent and sac6 spores do not germinate at elevated temperatures. Spores germinated at 30°C generate slow growing mycelia without displaying polarity establishment defects at the hyphal tip. Several phenotypic characteristics of sac6 hyphae resemble those found in wal1 mutants. First, tips of sac6 hyphae shifted to 37°C swell and produce subapical bulges. Second, actin patches are mislocalized subapically. And third, the rate of endocytotic uptake of the vital dye FM4-64 was reduced. This indicates that actin filament bundling, a conserved function of fimbrins, is required for fast polarized hyphal growth, polarity maintenance, and endocytosis in filamentous fungi. PMID:21237627

Jorde, Sigyn; Walther, Andrea; Wendland, Jürgen

2011-03-20

243

Recent advances in understanding the etiology and pathogenesis of pediatric germ cell tumors.  

PubMed

Pediatric germ cell tumors (GCTs) are rare neoplasms arising predominantly in the gonads and sacrococcygeal, mediastinal, and intracranial localizations. In this article, we review current knowledge of pathogenesis of pediatric GCTs, which differs from adult/adolescent GCTs. One distinctive feature is the absence of a progenitor stage, such as carcinoma in situ or gonadoblastoma, which are seen in adult/adolescent GCTs, except spermatocytic seminoma. The primordial germ cell (PGC) is the suggested origin of all GCTs, with variations in histology reflecting differentiation stage. Expression of pluripotency transcription factors OCT-3/4, NANOG, and AP-2? in germinomas/seminomas/dysgerminomas is consistent with retaining a germ cell phenotype. Teratomas, in contrast, develop through a pathway of aberrant somatic differentiation of immature germ cells, and the yolk sac tumors and choriocarcinomas result from abnormal extraembryonic differentiation. In pediatric GCTs, origin is suggested at an earlier developmental stage because of predisposing genetic factors, although responsible genes remain largely unknown. Some extragonadal GCTs have been linked to overexpression of the KIT/KITLG system, allowing for survival of aberrantly migrated ectopic PGCs. Infant gonadal/sacrococcygeal GCTs may be caused by apoptosis-related pathways, consistent with an association with polymorphisms in BAK1. Although recent advances have identified candidate pathways, further effort is needed to answer central questions of pathogenesis of these fascinating tumors. PMID:24577549

Mosbech, Christiane H; Rechnitzer, Catherine; Brok, Jesper S; Rajpert-De Meyts, Ewa; Hoei-Hansen, Christina E

2014-05-01

244

Dedifferentiated chondrosarcoma arising in the orbit.  

PubMed Central

Orbital chondrosarcomas are extremely rare and are usually an extension of tumours involving the paranasal sinuses. A unique case of dedifferentiated chondrosarcoma arising solely within the orbit is presented. Images

Potts, M J; Rose, G E; Milroy, C; Wright, J E

1992-01-01

245

Boundary Estimation Problems Arising in Thermal Tomography.  

National Technical Information Service (NTIS)

Problems on the identification of two-dimensional spatial domains arising in the detection and characterization of structural flaws in materials are considered. For a thermal diffusion system with external boundary input, observations of the temperature o...

H. T. Banks F. Kojima W. P. Winfree

1989-01-01

246

Intraosseous leiomyosarcoma arising in the epiphysis of the distal femur.  

PubMed

Herein, we present a rare case of intraosseous leiomyosarcoma arising in the epiphysis of the distal femur and showing unusual radiographic features. A 44-year-old man presented with a pain in the left knee joint. Computed tomography revealed an intraosseous lesion with slightly increased attenuation and a thin marginal sclerotic rim in the femoral medial condyle. The signal of the lesion was hypointense on T1-weighted magnetic resonance (MR) images and hyperintense on fat-suppressed T2-weighted MR images. After gadolinium administration, the signal of the lesion was moderately and diffusely enhanced. The histological diagnosis of leiomyosarcoma was made based on a preoperative core biopsy specimen. Microscopic examination of the resected specimen revealed an ill-defined intraosseous tumor composed of proliferated atypical and mildly pleomorphic smooth muscle cells permeating among the bone trabeculae with only focal destruction of the bone trabeculae and low mitotic activity, indicating low grade leiomyosarcoma. The bone trabeculae at the periphery of the tumor were mildly thickened and anastomosed with a rim of an increased number of osteoblasts. Systemic examination showed no tumorous lesions in other anatomical sites. Leiomyosarcomas rarely present in the bone as a diffuse intertrabecular growth, even in low grade tumors. PMID:23856273

Matsuyama, Atsuji; Sakamomo, Akio; Aoki, Takatoshi; Hisaoka, Masanori

2013-08-01

247

Tumor stem cells  

Microsoft Academic Search

Stem cells possess two basic characteristics: they are able to renew themselves and to develop into different cell types.\\u000a The link between normal stem cells and tumor cells could be examined in three aspects: what are the differences and similarities\\u000a in the control of self-renewal capacity between stem cells and tumor cells; whether tumor cells arise from stem cells; do

László Kopper; Melinda Hajdú

2004-01-01

248

Multiscale Modeling of the Effect of Micro-alloying Mn and Sb on the Viscoplastic Response of SAC105 Solder  

NASA Astrophysics Data System (ADS)

This study investigates the time-dependent viscoplastic response of two relatively new SAC105-X solders—SAC105-05Mn (Sn1.0Ag0.5Cu (SAC105) doped with 0.05 wt.% Mn), and SAC105-55Sb (SAC105 doped with 0.55 wt.% Sb). The results showed that the addition of Mn or Sb increases the creep resistance of SAC105 solder by one to two orders of magnitude at the tested stress levels of 2-20 MPa. The addition of Mn as a fourth alloying element promotes homogeneous distribution of micron-scale Cu6Sn5 intermetallic compounds (IMCs), thereby reducing their interparticle spacing as compared to that of SAC105. On the other hand, addition of Sb does not change the spacing of the Cu6Sn5 particle, but promotes the formation of uniformly sized Sn dendritic lobes, homogeneously distributed in the whole solder joint. Moreover, Sb also forms a solid solution with Sn and strengthens the Sn matrix in SAC105-55Sb itself. The effects of these microstructural changes (obtained using image processing) on the secondary creep constitutive response of SAC105 solder interconnects were then modeled using a mechanistic multiscale creep model. The mechanistic model was able to accurately capture the trends in the secondary creep constitutive response of the alloys and to explain the improvement in creep resistance of SAC105 due to the addition of Mn and Sb.

Mukherjee, Subhasis; Dasgupta, Abhijit; Zhou, Bite; Bieler, Thomas R.

2014-04-01

249

Cytogenetics of cranial base tumors  

Microsoft Academic Search

Summary Many different tumor types can arise in or invade the skull base. The more common tumors include, but are not limited to, angiofibromas, chondrosarcomas, chordomas, hemangiopericytomas, meningiomas, carcinomas, olfactory neuroblastomas, paragangliomas, pituitary adenomas, and rhabdomyosarcomas. Several of these tumors, including meningiomas, hemangiopericytomas, and rhabdomyosarcomas are characterized by nonrandom cytogenetic abnormalities. In this paper, we review the recognized chromosomal aberrations

Susanne M. Gollin; Ivo P. Janecka

1994-01-01

250

Exophytic glioblastoma arising from the cerebellum: case report and critical review of the literature.  

PubMed

Exophytic glioblastoma arising from the cerebellar tonsil is an extremely rare variant within the possible anatomical presentations of the glioblastoma multiforme (GBM). We report the case of a 55-year-old woman who presented with a tumor located at the cranio-cervical junction with compression of the medulla oblongata and consecutive hydrocephalus. Due to the radiological presentation, the first tentative diagnosis was a meningioma. The tumor was microsurgically removed. Histopathological examination of the tumor revealed a GBM WHO IV. The patient underwent a postoperative percutaneous radiotherapy and concomitant chemotherapy with temozolomide. GBM should be also considered in the differential diagnosis of cerebellar tumors. PMID:22777924

Linsenmann, Thomas; Monoranu, Camelia Maria; Westermaier, Thomas; Varallyay, Csanad; Ernestus, Ralf-Ingo; Vince, Giles Hamilton

2013-07-01

251

IgG is transported across the mouse yolk sac independently of Fc?RIIb  

PubMed Central

It is generally accepted that FcRn is the major IgG transporter in human syncytiotrophoblast and the mouse yolk sac endoderm, however the finding of a different Fc receptor Fc?RIIb (RIIb) in the human placental endothelium has suggested the existence of an additional IgG transporter. To test this hypothesis in the mouse, we utilized wild-type (RIIb+/+) mice and mice with a null mutation in the gene encoding RIIb (RIIb?/? mice). We found that while RIIb is expressed in the placental yolk sac vasculature of RIIb+/+ mice, the IgG concentrations in fetuses of RIIb+/+ mice and RIIb?/?mice are not different. This result refutes the hypothesis that yolk sac RIIb is required for transport of IgG in utero in the mouse. However, the capillary bed in the mouse yolk sac is structurally more complex than in human placenta, consisting of 3 types of cells: an RIIb-negative endothelium, a unique RIIb-bearing cell that also expresses two out of four macrophage markers but not endothelial cell or pericyte markers, and pericytes. As in the human placenta the b2 isoform of RIIb predominates in the mouse yolk sac. Remarkably only a single capillary channel rather than two channels with a loop is found in each yolk sac villus, which along with intracapillary erythrocytes, suggests that blood flow is peristaltic and mediated by pericytes. It is not clear whether RIIb in the human placental villus might contribute to IgG transport function in light of our finding that the mouse yolk sac equivalent is unnecessary in this role.

Mohanty, Sudhasri; Kim, Jonghan; Ganesan, Latha P.; Phillips, Gary S.; Hua, Keding; Jarjoura, David; Hayton, William L.; Robinson, John M.; Anderson, Clark L.

2011-01-01

252

Specificity determinants and structural features in the RNA target of the bacterial antiterminator proteins of the BglG/SacY family.  

PubMed Central

Induction of the Bacillus subtilis sacB gene and sacPA operon and Escherichia coli bgl operon is mediated by structurally homologous antiterminators encoded by the sacY, sacT, and bglG genes, respectively. When activated, these proteins prevent early transcription termination at terminators located in the leader regions of the three operons. BglG was previously shown to bind in vitro to an imperfectly palindromic 29-nucleotide RNA sequence located upstream of the terminator and partially overlapping with it [Houman, F., Diaz-Torres, M.R. & Wright, A. (1990) Cell 62, 1153-1163]. Similar motifs, here termed ribonucleic antiterminators (RATs), strongly conserved in sequence and in position, are found in the leader of both sacB and sacPA. Mutations were created in sacB RAT and tested in B. subtilis; this showed that sacB RAT is the target for SacY-mediated induction of sacB and that a stem-loop structure in the mRNA is required for regulatory function. Mutations increasing the similarity of the sacB RAT with those of sacPA or bgl rendered sacB inducible by SacT or BglG, respectively; most of these changes did not strongly affect induction by SacY, suggesting that the nucleotides at these variable positions act as negative specificity determinants. Images

Aymerich, S; Steinmetz, M

1992-01-01

253

Primary mixed germ cell tumor of the liver with sarcomatous components  

PubMed Central

Germ cell tumor (GCT) of the liver is extremely rare. Here, we describe a case of hepatic mixed GCT with significant sarcomatous components and elevated serum ?-fetoprotein (AFP) in a 34-year-old man. Histopathologically, the tumor was composed of two GCTs components: yolk sac tumor and immature teratoma. The predominant components of immature teratoma consisted of several types of tissue that represented different germinal layers (endoderm, mesoderm and ectoderm) and showed varying degrees of differentiation with significant sarcomatous components. The yolk sac component showed positivity for AFP and cytokeratin (AE1/AE3). The immature teratoma components showed positivity for varying differentiation markers. Interphase cytogenetic analysis revealed that the yolk sac tumor and immature teratoma were positive for i(12p) and 12p over-representation. In particular, the rhabdomyoblastic components also showed typical i(12p) and 12p overrepresentation. This suggested that sarcomatous components may be associated with dedifferentiation or malignant transformation of certain mesenchymal components within teratoma.

Xu, Ai-Min; Gong, Shao-Juan; Song, Wei-Hua; Li, Xiao-Wei; Pan, Chun-Hua; Zhu, Jun-Jun; Wu, Meng-Chao

2010-01-01

254

Granular Cell Tumors of the Heart.  

National Technical Information Service (NTIS)

In a study of granular cell tumors arising in the hearts of three patients, no evidence was found, either histologically or ultrastructurally, to support the hypothesis that these tumors are derived from striated muscle or cardiac muscle. The anatomic loc...

J. J. Fenoglio H. A. McAllister

1975-01-01

255

Case of primary diffuse large B-cell lymphoma of lacrimal sac in a Japanese patient  

PubMed Central

The purpose of this study was to determine the characteristics of primary diffuse large B-cell lymphoma (DLBCL) of the lacrimal sac. A 77-year-old man had epiphora of the right eye for three years. After visiting five clinics and hospitals, he was referred to our hospital, and the preoperative magnetic resonance imaging findings suggested a lacrimal sac mass. Dacryocysteography showed an obstruction of the right nasolacrimal duct, so we performed dacryocystectomy. After a histopathologic examination of the specimen, the patient was diagnosed with a DLBCL. Positron emission tomography scanning excluded metastases, and the final diagnosis was made of a primary DLBCL of the right lacrimal sac. He underwent radiotherapy with 30.6 Gray in total to the right lacrimal sac. After radiotherapy, no recurrence has been observed anywhere in his body for one year. Although a malignant lymphoma of the lacrimal sac is rare, clinicians should consider a primary malignant lymphoma in the differential diagnosis in patients with chronic dacryocystitis.

Kajita, Fusae; Oshitari, Toshiyuki; Yotsukura, Jiro; Asanagi, Kaoru; Baba, Takayuki; Kishimoto, Takashi; Yamamoto, Shuichi

2010-01-01

256

Case of primary diffuse large B-cell lymphoma of lacrimal sac in a Japanese patient.  

PubMed

The purpose of this study was to determine the characteristics of primary diffuse large B-cell lymphoma (DLBCL) of the lacrimal sac. A 77-year-old man had epiphora of the right eye for three years. After visiting five clinics and hospitals, he was referred to our hospital, and the preoperative magnetic resonance imaging findings suggested a lacrimal sac mass. Dacryocysteography showed an obstruction of the right nasolacrimal duct, so we performed dacryocystectomy. After a histopathologic examination of the specimen, the patient was diagnosed with a DLBCL. Positron emission tomography scanning excluded metastases, and the final diagnosis was made of a primary DLBCL of the right lacrimal sac. He underwent radiotherapy with 30.6 Gray in total to the right lacrimal sac. After radiotherapy, no recurrence has been observed anywhere in his body for one year. Although a malignant lymphoma of the lacrimal sac is rare, clinicians should consider a primary malignant lymphoma in the differential diagnosis in patients with chronic dacryocystitis. PMID:21179217

Kajita, Fusae; Oshitari, Toshiyuki; Yotsukura, Jiro; Asanagi, Kaoru; Baba, Takayuki; Kishimoto, Takashi; Yamamoto, Shuichi

2010-01-01

257

A status report on the development of SAC2000: A new seismic analysis code  

SciTech Connect

We are developing a new Seismic Analysis Code (SAC2000) that will meet the research needs of the seismic research and treaty monitoring communities. Our first step in this development was to rewrite the original Seismic Analysis Code (SAC) -- a Fortran code that was approximately 140,000 lines long -- in the C programming language. This rewrite has resulted in a much more robust code that is faster, more efficient, and more portable than the original. We have implemented important processing capabilities such as convolution and binary monograms, and we have significantly enhanced several previously existing capabilities. For example, the spectrogram command now produces a correctly registered plot of the input time series and a color image of the output spectrogram. We have also added an image plotting capability with access to 17 predefined color tables or custom color tables. A rewritten version of the readcss command can now be used to access any of the documented css.3.0 database data formats, a capability that is particularly important to the Air Force Technical Applications Center (AFTAC) and the monitoring community. A much less visible, but extremely important contribution is the correction of numerous inconsistencies and errors that have evolved because of piecemeal development and limited maintenance since SAC was first written. We have also incorporated on-line documentation and have made SAC documentation available on the Internet via the world-wide-web at http://www-ep/tvp/sac.html.

Goldstein, P.; Minner, L.

1995-08-01

258

The Sac domain-containing phosphoinositide phosphatases: structure, function, and disease  

PubMed Central

Phosphoinositides (PIs) have long been known to have an essential role in cell physiology. Their intracellular localization and concentration must be tightly regulated for their proper function. This spatial and temporal regulation is achieved by a large number of PI kinases and phosphatases that are present throughout eukaryotic species. One family of these enzymes contains a conserved PI phosphatase domain termed Sac. Although the Sac domain is homologous among different Sac domain-containing proteins, all appear to exhibit varied substrate specificity and subcellular localization. Dysfunctions in several members of this family are implicated in a range of human diseases such as cardiac hypertrophy, bipolar disorder, Down’s syndrome, Charcot-Marie-Tooth disease (CMT) and Amyotrophic Lateral Sclerosis (ALS). In plant, several Sac domain-containing proteins have been implicated in the stress response, chloroplast function and polarized secretion. In this review, we focus on recent findings in the family of Sac domain-containing PI phosphatases in yeast, mammal and plant, including the structural analysis into the mechanism of enzymatic activity, cellular functions, and their roles in disease pathophysiology.

HSU, FoSheng; MAO, Yuxin

2014-01-01

259

Myelofibrosis arising in treated histiocytosis X  

Microsoft Academic Search

Myelofibrosis, or fibrous replacement of hematopoietic bone marrow, is rarely encountered in pediatric patients. An unusual, reversible case arising in the setting of treated histiocytosis X is reported, a previously undescribed association. The clinical, pathologic, radiographic, and scintigraphic characteristics of myelofibrosis are reviewed.

D. J. Sartoris; D. Resnick

1985-01-01

260

ARISE: American renaissance in science education  

SciTech Connect

The national standards and state derivatives must be reinforced by models of curricular reform. In this paper, ARISE presents one model based on a set of principles--coherence, integration of the sciences, movement from concrete ideas to abstract ones, inquiry, connection and application, sequencing that is responsive to how people learn.

NONE

1998-09-14

261

Chronic dacryocystitis with spontaneous resolution of sac mucocele: fact or fiction.  

PubMed

The purpose of this study is to highlight the rare possibility of spontaneous resolution of a lacrimal sac mucocele by means of a retrospective case note analysis. The authors identified 3 patients with nasolacrimal duct obstruction and clinical and radiological evidence of mucocele. In all 3 cases, resolution of symptoms was reported prior to dacryocystorhinostomy. In each case, the mucocele was no longer palpable, and the patency of the nasolacrimal duct was confirmed by sac washout. A lacrimal sac mucocele may rarely rupture in the nose and resolve spontaneously. Although this is a rare outcome, lacrimal surgeons should be aware of this prospect to avoid unnecessary surgery and investigations. The authors recommend that lacrimal surgeons present spontaneous resolution as one of the possible outcomes in their patient information literature. PMID:20940660

Klodnicka, Katarzyna E; Ahluwalia, Harpreet

2011-01-01

262

Characterization and Comparison of Five SAC-based Solder Pastes for Pb-free Reflow Soldering  

Microsoft Academic Search

Based on literature review and industry survey, five types lead-free solder pastes, namely, SAC305 (96.5%Sn-3.0%Ag-0.5%Cu), SAC387 (95.5%Sn-3.8%Ag-0.7%Cu), SACS (96.2%Sn-2.5%Ag-0.8%Cu-0.5%Sb), SCN (99.3%Sn-0.7%Cu-0.05%Ni), and SACC (96.4%Sn-3.0%Ag-0.6%Cu-0.01%Ce) are studied in this paper. The basic properties of selected Pb-free solder pastes are tested based on IPC standards. These tests include solder paste particle size analysis, measurement of melting point, solder balling test, tack test

C. H. Chen; W. Wong; J. C. C. Lo; Fubin Song; S. W. R. Lee

2007-01-01

263

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages.  

PubMed

Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise from hematopoietic precursors that seed the skin before birth. However, the origin of these embryonic precursors remains unclear. Using in vivo lineage tracing, we identify a first wave of yolk sac (YS)-derived primitive myeloid progenitors that seed the skin before the onset of fetal liver hematopoiesis. YS progenitors migrate to the embryo proper, including the prospective skin, where they give rise to LC precursors, and the brain rudiment, where they give rise to microglial cells. However, in contrast to microglia, which remain of YS origin throughout life, YS-derived LC precursors are largely replaced by fetal liver monocytes during late embryogenesis. Consequently, adult LCs derive predominantly from fetal liver monocyte-derived cells with a minor contribution of YS-derived cells. Altogether, we establish that adult LCs have a dual origin, bridging early embryonic and late fetal myeloid development. PMID:22565823

Hoeffel, Guillaume; Wang, Yilin; Greter, Melanie; See, Peter; Teo, Pearline; Malleret, Benoit; Leboeuf, Marylène; Low, Donovan; Oller, Guillaume; Almeida, Francisca; Choy, Sharon H Y; Grisotto, Marcos; Renia, Laurent; Conway, Simon J; Stanley, E Richard; Chan, Jerry K Y; Ng, Lai Guan; Samokhvalov, Igor M; Merad, Miriam; Ginhoux, Florent

2012-06-01

264

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages  

PubMed Central

Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise from hematopoietic precursors that seed the skin before birth. However, the origin of these embryonic precursors remains unclear. Using in vivo lineage tracing, we identify a first wave of yolk sac (YS)–derived primitive myeloid progenitors that seed the skin before the onset of fetal liver hematopoiesis. YS progenitors migrate to the embryo proper, including the prospective skin, where they give rise to LC precursors, and the brain rudiment, where they give rise to microglial cells. However, in contrast to microglia, which remain of YS origin throughout life, YS-derived LC precursors are largely replaced by fetal liver monocytes during late embryogenesis. Consequently, adult LCs derive predominantly from fetal liver monocyte-derived cells with a minor contribution of YS-derived cells. Altogether, we establish that adult LCs have a dual origin, bridging early embryonic and late fetal myeloid development.

Hoeffel, Guillaume; Wang, Yilin; Greter, Melanie; See, Peter; Teo, Pearline; Malleret, Benoit; Leboeuf, Marylene; Low, Donovan; Oller, Guillaume; Almeida, Francisca; Choy, Sharon H.Y.; Grisotto, Marcos; Renia, Laurent; Conway, Simon J.; Stanley, E. Richard; Chan, Jerry K.Y.; Ng, Lai Guan; Samokhvalov, Igor M.

2012-01-01

265

Oncocytic adrenocortical neoplasm arising from adrenal rest in the broad ligament of the uterus.  

PubMed

Oncocytic adrenocortical neoplasm is characterized by abundant eosinophilic cytoplasm containing mitochondria, occasional nuclear atypia and diffuse growth pattern. Oncocytic adrenocortical neoplasm arising in adrenal rest is, however, extremely rare. We report a case of oncocytic adrenocortical neoplasm arising in adrenal rest of the broad ligament with associated marked lipomatous metaplasia. A well circumscribed tumor was accidentally detected in the pelvic cavity of a 29 year old Japanese woman, adjacent to the broad ligament of the uterus. The tumor was composed of large eosinophilic cells associated with diffuse growth pattern and abundant mature adipose tissue admixed with foci of clear cells. Both steroidgenic factor 1 (SF-1) and alpha-inhibin were immunohistochemically positive in tumor cells. Abundant mitochondria detected by immunohistochemical and electron microscopic examination confirmed the diagnosis of oncocytic adrenocortical neoplasm. The absence of necrosis, capsular and vascular invasion as well as the low mitotic index indicated the benign potential of this tumor. The tumor cells were also positive for dehydroepiandrosteron-sulfotransferase (DHEA-ST), 17?-hydroxysteroid dehydrogenase type 5 (17?-HSD5), 3?-hydroxysteroid dehydrogenase (3?-HSD) and steroid 17?-hydroxylase (P450-c17), suggesting a possible production of testosterone of this tumor. This is the first reported case of oncocytic adrenocortical adenoma arising in adrenal rest of the broad ligament. PMID:24750189

Kasajima, Atsuko; Nakamura, Yasuhiro; Adachi, Yuzu; Takahashi, Yayoi; Fujishima, Fumiyoshi; Chiba, Yutaka; Uehara, Shigeki; Watanabe, Mika; Sasano, Hironobu

2014-04-01

266

Cavernous hemangioma arising from the diaphragm.  

PubMed

A 51-year-old man was referred to our hospital with an abnormal nodule in the right lung field. Computed tomography revealed a homogeneous nodule adjacent to the diaphragm, which appeared to be an extrapulmonary lesion. No hilar or mediastinal lymph node swelling was detected, and positron-emission tomography showed no significant uptake. At surgery, 2 red papillary tumors were found, originating from the right diaphragm, and tumor extirpation was performed. The pathological diagnosis was cavernous hemangioma. PMID:24569338

Ueno, Katsuhito; Takeuchi, Eriho; Hino, Haruaki; Kawashima, Mitsuaki

2013-12-01

267

Primary yolk sac tumour of the urinary bladder: A case report and review of the literature  

PubMed Central

We present a case of rare primary yolk sac tumour of the urinary bladder in adulthood. A 31-year-old female patient presented with a history of chronic ketamine abuse, which has not previously been shown to be associated with malignancy development. The final diagnosis was established only after radical cystectomy. A computed tomography (CT) scan showed paraaortic lymph node metastasis. The patient was treated with systemic chemotherapy. A review of the literature revealed that surgical excision and cisplatin-based chemotherapy remain to be the standard of care for extragonadal yolk sac tumours.

MUI, WING HO; LEE, KA CHAI; CHIU, SIN CHUEN; PANG, CHUN YIN; CHU, SAU KWAN; MAN, CHI WAI; WONG, CHI SING; SZE, WING KIN; TUNG, YUK

2014-01-01

268

[Typical tumors of the petrous bone].  

PubMed

In the region of the petrous bone, inner acoustic canal and cerebellopontine angle, a variety of different tissues can be found, such as bony, epithelial, neural and vascular structures. Tumorous or tumor-like lesions, vascular or bony malformations or other pathologies can therefore be found in all of these areas. We discuss various frequently occurring tumorous or tumor-like pathologies including congential lesions, such as mucoceles, inflammatory disorders including osteomyelitis, pseudotumors and Wegener's granulomatosis. Benign non-neoplastic lesions, such as cholesteatoma, cholesterol granuloma, epidermoid and benign neoplastic tumors, such as the most commonly found vestibular schwannoma, meningeoma, paraganglioma, vascular pathologies and finally malignant lesions, such as metastasis, chordoma or chondrosarcoma and endolymphatic sac tumor (ELST) are also discussed. The emphasis of this article is on the appearance of these entities in computed tomography (CT) and more so magnetic resonance imaging (MRI), it provides key facts and typical images and discusses possibilities how to distinguish these pathologies. PMID:24692010

Ahlhelm, F; Müller, U; Ulmer, S

2014-04-01

269

Adenolipoma of the Skin Arising at Neck Region  

PubMed Central

We report here a case of adenolipoma of the skin, an unusual variant of lipoma, arising on the neck. A 56-year-old man visited our hospital due to an anterior neck mass. An excisional biopsy was performed. The mass revealed a tan-yellow soft cut surface. We could not find any difference from other lipoma on gross inspection. Microscopically, the mass showed proliferation of mature adipocytes admixed with several eccrine units. The eccrine units were demonstrated by periodic acid-Schiff-positive granules in the secretory portions and by positivity of smooth muscle actin in the myoepithelial cells surrounding the eccrine glands. The tumor was completely excised, and the patient has been followed up without any evidence of recurrence so far.

Song, Yoon Sang

2012-01-01

270

Clear Cell Adenocarcinoma Arising from Abdominal Wall Endometriosis  

PubMed Central

Endometriosis is a frequent benign disorder. Malignancy arising in extraovarian endometriosis is a rare event. A 49-year-old woman is presented with a large painful abdominal wall mass. She underwent a myomectomy, 20 years before, for uterus leiomyoma. Computed tomography suggested that this was a desmoid tumor and she underwent surgery. Histological examination showed a clear cell adenocarcinoma associated with endometriosis foci. Pelvic ultrasound, computed tomography, and endometrial curettage did not show any malignancy or endometriosis in the uterus and ovaries. Adjuvant chemotherapy was recommended, but the patient was lost to follow up. Six months later, she returned with a recurrence of the abdominal wall mass. She was given chemotherapy and then she was reoperated.

Achach, Thouraya; Rammeh, Soumaya; Trabelsi, Amel; Ltaief, Rached; Ben Abdelkrim, Soumaya; Mokni, Moncef; Korbi, Sadok

2008-01-01

271

Endometrial carcinoma arising within extensive intrauterine synechiae.  

PubMed

In patients with intrauterine adhesions severe enough to produce amenorrhoea, biologically active endometrium can undergo malignant change. To our knowledge, this is the first reported case of endometrial carcinoma arising within intrauterine synechiae. A 71-year-old woman receiving unopposed estrogen developed post-menopausal bleeding. At endovaginal sonography we detected a polypoid mass. Extensive intrauterine synechiae within the uterus were noted during hysteroscopy, and a polypoid lesion was seen adjacent to a synechia. Biopsy demonstrated endometrial adenocarcinoma arising from a synechia. Hysterectomy and bilateral salpingo-oophorectomy were performed. A well-differentiated adenocarcinoma of the endometrium was demonstrated. Asherman syndrome and endometrial adenocarcinoma can exist simultaneously. In such cases, hysteroscopy is essential for diagnosis of synechiae and for target biopsy. PMID:7805969

Sandridge, D A; Councell, R B; Thorp, J M

1994-08-01

272

The fine structure of the maxillary gland of the brine shrimp, Artemia salina : The end-sac  

Microsoft Academic Search

The gross morphology of the maxillary gland of the adult brine shrimp, Artemia salina, was studied by light microscopy, and some features of Warren's (1938) original description of the gland were confirmed. Each gland consists of two parts: an end-sac and an efferent excretory duct. The end-sac is centrally located, and around it the efferent duct coils, making three loops

Greta E. Tyson

1968-01-01

273

Nipple adenoma arising from axillary accessory breast: a case report  

PubMed Central

Nipple adenoma is a relatively rare benign breast neoplasm, and cases of the disease arising from the axillary accessory breast have very seldom been reported in the English literature. We report a case of nipple adenoma arising from axillary accessory breast including clinical and pathological findings. An 82-year-old woman presented with the complaint of a small painful mass in the right axilla. Physical examination confirmed a well-defined eczematous crusted mass that was 8 mm in size. The diagnosis of nipple adenoma was made from an excisional specimen on the basis of characteristic histological findings. Microscopic structural features included a compact proliferation of small tubules lined by epithelial and myoepithelial cells, and the merging of glandular epithelial cells of the adenoma into squamous epithelial cells in the superficial epidermal layer. Because clinically nipple adenoma may resemble Paget’s disease and pathologically can be misinterpreted as tubular carcinoma, the correct identification of nipple adenoma is an important factor in the differential diagnosis for axillary tumor neoplasms. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1186821489769063

2012-01-01

274

[Therapeutic pathomorphosis of bone tumors].  

PubMed

A comparative study of therapeutic pathomorphosis of bone tumors has shown that radiosensitive and radioresistant tumors differ in the time-course and nature of radiation-induced pathomorphosis. In radiosensitive tumors, the resultant changes arise earlier, are more strongly marked, and, as a rule, necrosis of the tumor with its replacement with fibrous tissue is observed. In radioresistant tumors, signs of radiation pathomorphosis appear later, "therapeutic giants" are typically seen to appear, and the direction in which tumor cell differentiate may change. PMID:3328592

Polonskaia, N Iu

1987-01-01

275

The corn snake yolk sac becomes a solid tissue filled with blood vessels and yolk-rich endodermal cells.  

PubMed

The amniote egg was a key innovation in vertebrate evolution because it supports an independent existence in terrestrial environments. The egg is provisioned with yolk, and development depends on the yolk sac for the mobilization of nutrients. We have examined the yolk sac of the corn snake Pantherophis guttatus by the dissection of living eggs. In contrast to the familiar fluid-filled sac of birds, the corn snake yolk sac invades the yolk mass to become a solid tissue. There is extensive proliferation of yolk-filled endodermal cells, which associate with a meshwork of blood vessels. These novel attributes of the yolk sac of corn snakes compared with birds suggest new pathways for the evolution of the amniote egg. PMID:24402715

Elinson, Richard P; Stewart, James R

2014-01-01

276

Influence of process parameters on SAC305 lead-free solder powder produced by centrifugal atomization  

Microsoft Academic Search

In the present work, a centrifugal atomizer was constructed in order to study the effects of operating parameters: rotating speed, melt feed rate, shape and size of atomizer, and oxygen content in the atomizer chamber, on the characters of SAC305 powder. It was evidenced from the experimental results that the median size of the atomized powders became smaller with increasing

Thawatchai Plookphol; Sirikul Wisutmethangoon; Sarawut Gonsrang

2011-01-01

277

Distribution and transfer pathways of antioxidant molecules inside the first trimester human gestational sac.  

PubMed

The first-trimester human placenta has limited antioxidant enzyme capacity. We investigated the distribution and transfer pathways of antioxidant molecules inside the first trimester gestational sac. The coelomic fluid of the exocoelomic cavity, which borders the inside of the first-trimester placenta, contained a very low level of reduced glutathione. Glutathione disulfide was undetectable in most coelomic samples, suggesting that the role of glutathione-related detoxification system is limited in fetal fluid compartments. The coelomic fluid contained similar concentrations of ascorbic and uric acid to maternal plasma. The levels of alpha- and gamma-tocopherol were lower in coelomic fluid, compared with maternal plasma. The presence of these molecules inside the early gestational sac suggests that they may play an essential role in the fetal tissues' antioxidant capacity at a time when the fetus is most vulnerable to oxidative stress. We also demonstrated by immunostaining the presence of alpha-tocopherol transfer protein in the cytoplasm of trophoblastic cells, glandular epithelium of the decidua, and mesothelial layer of the secondary yolk sac. This finding indicates that the uterine glands and the secondary yolk sac play key roles in supplying this essential vitamin to the developing fetus before the placental circulations are established. PMID:15001647

Jauniaux, Eric; Cindrova-Davies, Tereza; Johns, Jemma; Dunster, Christina; Hempstock, Joanne; Kelly, Frank J; Burton, Graham J

2004-03-01

278

Fatty acid esterification in the yolk sac membrane of the avian embryo  

Microsoft Academic Search

The transfer of lipid from the yolk to the avian embryo is mediated by the yolk sac membrane (YSM). Some, but not all, of the published morphological evidence supports the view that the lipid undergoes a cycle of hydrolysis and re-esterification during translocation across the YSM. The present study aims to test this view by investigating the capacity of the

K. A. Powell; E. A. Deans; B. K. Speake

2004-01-01

279

Cloning and sequencing of the sacA gene: characterization of a sucrase from Zymomonas mobilis.  

PubMed Central

The Zymomonas mobilis gene (sacA) encoding a protein with sucrase activity has been cloned in Escherichia coli and its nucleotide sequence has been determined. Potential ribosome-binding site and promoter sequences were identified in the region upstream of the gene which were homologous to E. coli and Z. mobilis consensus sequences. Extracts from E. coli cells, containing the sacA gene, displayed a sucrose-hydrolyzing activity. However, no transfructosylation activity (exchange reaction or levan formation) could be detected. This sucrase activity was different from that observed with the purified extracellular protein B46 from Z. mobilis. These two proteins showed different electrophoretic mobilities and molecular masses and shared no immunological similarity. Thus, the product of sacA (a polypeptide of 58.4-kDa molecular mass) is a new sucrase from Z. mobilis. The amino acid sequence, deduced from the nucleotide sequence of sacA, showed strong homologies with the sucrases from Bacillus subtilis, Salmonella typhimurium, and Vibrio alginolyticus.

Gunasekaran, P; Karunakaran, T; Cami, B; Mukundan, A G; Preziosi, L; Baratti, J

1990-01-01

280

Appendiceal pus in a hernia sac simulating strangulated femoral hernia: a case report  

PubMed Central

Acute appendicitis involving the hernia sac is infrequent but well-documented in medical literature. In most instances, it occurs within the right inguinal (Amyand’s hernia) or right femoral hernia (de Garengeot hernia). The diagnosis is always mistaken for incarcerated groin hernia. During surgery, the appendix itself, either perforated or strangulated, is most commonly encountered within the hernia sac. In very rare occasions, only appendiceal pus is found in the hernia sac. In this paper, we report the case of a 90-year-old woman with acute appendicitis and a tender mass in the right groin. Typical findings of acute appendicitis by computed tomography (CT) and incarcerated femoral hernia with groin cellulitis misled us into preoperative diagnosis of strangulated femoral hernia. Acute phlegmonous inflammation of the incarcerated femoral hernia sac containing pus only and acute suppurative appendicitis were found intraoperatively. This case presents a rare complication of acute appendicitis and the first report of CT-documented appendiceal pus-contained femoral hernia. Knowledge of this rare condition is helpful in establishing preoperative diagnosis and patient management decisions.

Hsiao, Tien-Fa; Chou, Yenn-Hwei

2011-01-01

281

Laparoscopy through the open ipsilateral sac to evaluate presence of contralateral hernia  

Microsoft Academic Search

Purpose: Laparoscopic evaluation of the contralateral side (LECS) in children with unilateral inguinal hernia (UIH) has been criticized because of the abdominal trocar risk and costs. LECS was modified to avoid abdominal trocar insertion by using the open hernia sac for instrumentation (OHLECS). This study was performed to determine the utility, safety, and effectiveness of this technique. Methods: During a

Mark L. Wulkan; Eugene S. Wiener; Nancy VanBalen; Peter Vescio

1996-01-01

282

[Complementary nuclear DNA in embryo sac cells of Haemanthus albiflos and Ornithogalum caudatum].  

PubMed

Cytophotometric measurements of Feulgen-DNA were carried out in the nuclei of embryo sac cells of Haemanthus albiflos and Ornithogalum caudatum. It was found that the nuclei of the egg system, haploid in the number of chromosomes, became polyploid in DNA amount at the final stages of gametophyte development. PMID:11963552

Morozova, E M

2002-01-01

283

Electron Microscopic Studies on Rickettsia Prowazecki in Ultra-Thin Sections of Yolk Sacs.  

National Technical Information Service (NTIS)

The electron microscopic study of Rickettsia prowazecki in ultra-thin sections of chick embryo yolk sacs and also of intact rickettsia in stained preparations prove that the structure of the micro-organisms is quite complex. The preparations clearly show ...

G. P. Handzii B. G. Zatulovskii L. Y. Shkolnik

1966-01-01

284

Cells of the connective tissue differentiate and migrate into pollen sacs  

NASA Astrophysics Data System (ADS)

In angiosperms, archesporial cells in the anther primordium undergo meiosis to form haploid pollen, the sole occupants of anther sacs. Anther sacs are held together by a matrix of parenchyma cells, the connective tissue. Cells of the connective tissue are not known to differentiate. We report the differentiation of parenchyma cells in the connective tissue of two Gordonia species into pollen-like structures (described as pseudopollen), which migrate into the anther sacs before dehiscence. Pollen and pseudopollen were distinguishable by morphology and staining. Pollen were tricolpate to spherical while pseudopollen were less rigid and transparent with a ribbed surface. Both types were different in size, shape, staining and surface architecture. The ratio of the number of pseudopollen to pollen was 1:3. During ontogeny in the connective tissue, neither cell division nor tetrad formation was observed and hence pseudopollen were presumed to be diploid. Only normal pollen germinated on a germination medium. Fixed preparations in time seemed to indicate that pseudopollen migrate from the connective tissue into the anther sac.

Iqbal, M. C. M.; Wijesekara, Kolitha B.

2002-01-01

285

In vitro/In vivo Comparison of Yolk-Sac Function and Embryo Development.  

National Technical Information Service (NTIS)

The yolk-sac function and development of rat embryos grown in vitro for 24hr, starting on day 10.5, were compared with those of embryos grown in utero. The embryos grown in vitro had significantly fewer somites, shorter crown-rump length and smaller yolk-...

J. E. Andrews M. Ebron-McCoy R. M. Zucker K. H. Elstein J. M. Rogers

1991-01-01

286

Imaging of Neuroendocrine Tumors  

Microsoft Academic Search

\\u000a Neuroendocrine tumors (NETs) arise from amine precursor uptake and decarboxylation (APUD) cells throughout the nervous and\\u000a endocrine systems, which produce and secrete regulatory hormones. NETs commonly originate in: (1) argentaffin cells of the\\u000a gut, resulting in carcinoid tumors, (2) endocrine cells in the pancreas, (3) calcitonin-producing thyroid cells, resulting\\u000a in medullary thyroid carcinoma (MTC), and (4) parathyroid, adrenal, and pituitary

Piyaporn Boonsirikamchai; Mohamed Khalaf Aly Asran; Chusilp Charnsangavej

287

Chordoid meningioma arising in the pineal region: a case report.  

PubMed

We report a rare case of chordoid meningioma arising in the pineal region, which presented in a 22-year-old woman. Her only complaint was headache, and neurological examination revealed no deficits. She had suffered from prolonged fever a few weeks earlier, and her hematological findings included hypochromic microcytic anemia and a high serum level of C-reactive protein (CRP). Cranial magnetic resonance (MR) images demonstrated a 25 x 30 mm mass in the pineal region, which showed iso-to low intensity on T1-weighted images (T1WI), high to low intensity on T2-weighted images (T2WI), and homogeneous enhancement with gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA). We performed subtotal removal of the tumor with an occipital transtentorial approach (OTA), and all her preoperative symptoms completely abated. Histological examination of this tumor specimen showed the typical pattern of chordoid meningioma. Chordoid meningioma has been known to correspond with Castleman's disease, and pineal meningiomas are extremely rare among intracranial meningiomas. The details of this case are presented with a review of the literature. PMID:18987835

Fukushima, Shintaro; Terasaki, Mizuhiko; Shigemori, Minoru

2008-01-01

288

Boundary estimation problems arising in thermal tomography  

NASA Technical Reports Server (NTRS)

Problems on the identification of two-dimensional spatial domains arising in the detection and characterization of structural flaws in materials are considered. For a thermal diffusion system with external boundary input, observations of the temperature on the surface are used in a output least squares approach. Parameter estimation techniques based on the method of mappings are discussed and approximation schemes are developed based on a finite element Galerkin approach. Theoretical convergence results for computational techniques are given and the results are applied to experimental data for the identification of flaws in the thermal testing of materials.

Banks, H. T.; Kojima, Fumio; Winfree, W. P.

1989-01-01

289

Kapteyn series arising in radiation problems  

NASA Astrophysics Data System (ADS)

In discussing radiation from multiple point charges or magnetic dipoles, moving in circles or ellipses, a variety of Kapteyn series of the second kind arises. Some of the series have been known in closed form for a hundred years or more, others appear not to be available to analytic persuasion. This paper shows how 12 such generic series can be developed to produce either closed analytic expressions or integrals that are not analytically tractable. In addition, the method presented here may be of benefit when one has other Kapteyn series of the second kind to consider, thereby providing an additional reason to consider such series anew.

Lerche, I.; Tautz, R. C.

2008-01-01

290

Endocrine Tumor  

MedlinePLUS

... tumor (includes information on adenomas and adrenocortical carcinoma) Carcinoid tumors (includes information on both lung and gastrointestinal carcinoid tumors) Islet cell tumor (includes information on gastrinoma, ...

291

Differential diagnosis of localized tumors of the gingiva.  

PubMed

Localized tumors arising from the periodontal structures are commonly seen in the oral cavity. Although not a daily occurrence, these tumors will probably be encountered by all practitioners during their professional lives. The majority of localized tumors arising from the periodontal structures are benign, but early recognition and treatment are imperative to prevent invasion and destruction of the surrounding structures. PMID:2088617

Brown, F H; Houston, G D

1990-12-01

292

Malignant rhabdoid tumor of liver  

PubMed Central

Malignant rhabdoid tumor (MRT) is a rare, but aggressive tumor commonly arising from the kidney in young children. Extrarenal MRT has been reported in the literature in various other sites including the liver, pelvis, CNS, abdomen, heart and other soft-tissues. Reported herein are the presentation, radiology, histopathology, immunohistochemistry, treatment and outcome of a 6 month infant with primary MRT of liver.

Agarwala, Sandeep; Jindal, Bibekanand; Jana, Manisha; Bhatnagar, Veereshwar; Gupta, Arun Kumar; Iyer, Venkateshwar K.

2014-01-01

293

Visceral Endoderm Expression of Yin-Yang1 (YY1) Is Required for VEGFA Maintenance and Yolk Sac Development  

PubMed Central

Mouse embryos lacking the polycomb group gene member Yin-Yang1 (YY1) die during the peri-implantation stage. To assess the post-gastrulation role of YY1, a conditional knock-out (cKO) strategy was used to delete YY1 from the visceral endoderm of the yolk sac and the definitive endoderm of the embryo. cKO embryos display profound yolk sac defects at 9.5 days post coitum (dpc), including disrupted angiogenesis in mesoderm derivatives and altered epithelial characteristics in the visceral endoderm. Significant changes in both cell death and proliferation were confined to the YY1-expressing yolk sac mesoderm indicating that loss of YY1 in the visceral endoderm causes defects in the adjacent yolk sac mesoderm. Production of Vascular Endothelial Growth Factor A (VEGFA) by the visceral endoderm is essential for normal growth and development of the yolk sac vasculature. Reduced levels of VEGFA are observed in the cKO yolk sac, suggesting a cause for the angiogenesis defects. Ex vivo culture with exogenous VEGF not only rescued angiogenesis and apoptosis in the cKO yolk sac mesoderm, but also restored the epithelial defects observed in the cKO visceral endoderm. Intriguingly, blocking the activity of the mesoderm-localized VEGF receptor, FLK1, recapitulates both the mesoderm and visceral endoderm defects observed in the cKO yolk sac. Taken together, these results demonstrate that YY1 is responsible for maintaining VEGF in the developing visceral endoderm and that a VEGF-responsive paracrine signal, originating in the yolk sac mesoderm, is required to promote normal visceral endoderm development.

Rhee, Siyeon; Guerrero-Zayas, Mara-Isel; Wallingford, Mary C.; Ortiz-Pineda, Pablo; Mager, Jesse; Tremblay, Kimberly D.

2013-01-01

294

Synovial chondrosarcoma arising in synovial chondromatosis.  

PubMed

Primary synovial chondromatosis (SC) is a rare proliferative disorder that causes pain, swelling, and restriction of movement to the joints it affects. The disease frequently runs a protracted course, often requiring multiple surgical procedures to obtain some control. Few reports exist detailing the natural history of SC, although malignant transformation to synovial chondrosarcoma (CHS) is recognized to be a rare event. The aim of our study was to review a large orthopaedic oncology database in order to evaluate the incidence of CHS arising from SC. We identified 78 patients who have presented to our centre with primary synovial chondromatosis (SC). Of those patients, 5 went on to develop malignant change. This represents a 6.4% incidence of developing synovial chondrosarcoma (CHS) within preexisting primary synovial chondromatosis. The patients had a mean age of 28 years at first diagnosis with synovial chondromatosis with the median time from original diagnosis to malignant transformation being 20 years (range 2.7-39?yrs). PMID:24737946

Evans, Scott; Boffano, Michele; Chaudhry, Samena; Jeys, Lee; Grimer, Robert

2014-01-01

295

Intracranial aneurysm arising from infundibular dilation.  

PubMed

Infundibular dilations (IDs) are funnel-shaped enlargements in the origin of intracranial arteries. Usually, IDs occur at the junction between posterior communicating artery (PcomA) and internal carotid artery (ICA). Progression from an ID of the PcomA to aneurysms has been described, but is unclear whether an ID is a preaneurysmal state or a normal anatomical variant. The authors describe a 55-year-old female patient presenting multiple intracranial aneurysms with a small one arising from an ID at the level of posterior communicating segment of ICA. To the best of our knowledge, after a criterious search in the English literature, it is the first description of such unusual combination. The preoperative neurosurgical planning is discussed as well as the importance of intraoperative findings to the best management of this unusual situation. PMID:23904431

Pereira, Benedito Jamilson Araujo; Holanda, Vanessa Milanesi; de Holanda, Carlos Vanderlei Medeiros; de Oliveira, Jean Goncalves

2013-01-01

296

Periorbital nodular fasciitis arising during pregnancy  

PubMed Central

Nodular fasciitis (NF) is a benign proliferation of fibroblasts and myofibroblasts that rarely occurs in the periorbital region. We report what we believe to be the first case of periorbital NF associated with pregnancy. A case of intravascular fasciitis, a NF variant, has been reported during pregnancy, but it was not located in the periorbital region. A weak presence of estrogen receptors has been reported in NF. This may make it more susceptible to the hormone-related changes during pregnancy and contribute to the development of the lesion by stimulating fibroblasts and smooth muscle cell types. Although rare, NF should be considered in the differential diagnosis of periorbital soft-tissue masses arising during pregnancy.

Phillips, Brandon N; Eiseman, Andrew S

2014-01-01

297

Survival of mutations arising during invasions  

PubMed Central

When a neutral mutation arises in an invading population, it quickly either dies out or ‘surfs’, i.e. it comes to occupy almost all the habitat available at its time of origin. Beneficial mutations can also surf, as can deleterious mutations over finite time spans. We develop descriptive statistical models that quantify the relationship between the probability that a mutation will surf and demographic parameters for a cellular automaton model of surfing. We also provide a simple analytic model that performs well at predicting the probability of surfing for neutral and beneficial mutations in one dimension. The results suggest that factors – possibly including even abiotic factors – that promote invasion success may also increase the probability of surfing and associated adaptive genetic change, conditioned on such success.

Miller, Judith R

2010-01-01

298

[A case report of malignant fibrous histiocytoma arising from the renal capsule].  

PubMed

A 58-year-old woman was found to have a tumor of the left kidney by ultrasonography and x-ray at a medical examination. Computed tomography showed a mass with calcification adjacent to the left kidney. The patient was successfully treated with open nephrectomy. Pathological examination revealed the malignant fibrous histiocytoma (MFH) arising from the renal capsule, striform-pleomorphic type, low grade malignancy. She was free of disease at fourteen months postoperatively. To our knowledge, this is the 26th case of MFH arising from the renal capsule in Japan. PMID:24322412

Matsushita, Makoto; Okada, Takayuki; Kawamura, Norihiko; Ujike, Takeshi; Nin, Mikio; Tsujihata, Masao

2013-11-01

299

Localization of Bacillus subtilis sacU(Hy) mutations to two linked genes with similarities to the conserved procaryotic family of two-component signalling systems.  

PubMed Central

Mutations in the sacU region have a pleiotropic phenotype. Certain mutations designated sacU(Hy), for example, express degradative enzymes at high levels, are able to sporulate in the presence of glucose, have severely reduced transformation efficiencies, and are nonmotile. We isolated and sequenced the sacU gene region of Bacillus subtilis. Two open reading frames were found in the sacU region, and sacU(Hy) mutations were localized to both of these open reading frames. The two open reading frames have similarities to two widespread families of proteins that mediate responses to environmental stimuli.

Henner, D J; Yang, M; Ferrari, E

1988-01-01

300

Anastomosis of nasal mucosal and lacrimal sac flaps in endoscopic dacryocystorhinostomy.  

PubMed

Endoscopic dacryocystorhinostomy (DCR) is a well-established alternative to external approaches in the treatment of nasolacrimal canal obstruction. From July 2004 to December 2008, 92 endoscopic DCRs were performed on 88 patients at the Department of Otorhinolaryngology, San Raffaele Hospital, Milan. All patients were affected by chronic dacryocystitis with epiphora. Preoperative work-up included Jones tests, lacrimal pathways irrigation, nasal endoscopy, and imaging evaluation by computed tomography. The technique involved anastomosis of nasal mucosal, lacrimal sac flaps and a large bony ostium. A silicone tube was inserted in all patients that remained for a period of 3 months. The first endoscopic intervention was successful in 91.30% of patients. After a second revision endoscopic DCR, the overall success rate raised to 95.65%. Anastomosis of nasal mucosal between lacrimal sac flaps plays a key role in endoscopic DCR with a high success rate both in primary nasolacrimal obstructions and in revision cases. PMID:19499237

Trimarchi, Matteo; Giordano Resti, A; Bellini, C; Forti, M; Bussi, M

2009-11-01

301

A unique case of diffuse histiocytic proliferations mimicking metastatic clear cell carcinoma in the hydrocele sac.  

PubMed

Reactive histiocytic proliferations are extremely rare in paratesticular structures. Nodular histiocytic proliferations have been described in mesothelial-lined locations and only at few nonmesothelial sites. Diffuse histiocytic proliferations are described only in the pelvic peritoneum. We report the first case of diffuse histiocytic proliferation in the hydrocele sac of a 45-year-old man. Predominant histiocytes showed clear cytoplasm and signet ring-like change. Mucicarmin stain did not demonstrate mucin in the cytoplasm. Immunohistochemistry (IHC) staining showed nonspecific staining of these cells with carcinoembryonic antigen and negative staining with epithelial membrane antigen, pan-Cytokeratin, calretinin, cytokeratin 7, 20 and prostate-specific antigen. Strong diffuse cytoplasmic positivity for CD68 defined the mononuclear phagocyte nature of these cells. Diffuse histiocytic proliferations can occur in the hydrocele sac. Histochemical and IHC stainings are critical for accurate diagnosis and to avoid unnecessary surgery. PMID:24696560

Chandanwale, Shirish S; Vimal, Shruti S; Rajpal, Mohit; Mishra, Neha

2014-01-01

302

Surgical Experience of Persistent Type 2 Endoleaks with Aneurysmal Sac Enlargement after Endovascular Aneurysm Repair  

PubMed Central

Herein, we present a case of a successful treatment of persistent type 2 endoleaks associated with aneurysmal sac enlargement after endovascular aneurysm repair in an elderly patient. We confirmed the diagnosis by abdominal computed tomography and selective angiography revealing an 11.0-cm aneurysm sac with type 2 endoleaks. An attempt for the endovascular embolization of collateral arteries was unsuccessful due to anatomic variations and their multiple complex communications. Instead, transperitoneal sacotomy and direct suturing on the feeding target vessels was successfully performed without any endograft damage. In conclusion, sacotomy appears to be a feasible therapeutic substitute where endovascular or other techniques have a high risk of failure and lead to unsuccessful results.

Bang, Seung Ho; Park, Jae Bum; Kim, Jun Seok; Jang, Il Soo

2014-01-01

303

[Our experience with the complex treatment of phlegmon of the lacrimal sac].  

PubMed

Eighty-nine patients with lacrimal sac phlegmons, 76 women and 13 men, aged 16 to 78, were administered multiple-modality treatment, consisting in Group 1 (43 patients) of traditional methods, such as UHF therapy, antibiotics, sulfonamides, symptomatic therapy, dacryocystorhinostomy after complete cessation of inflammation, and in group 2 (46 patients) including sessions of intermittent magnetic field (IMF) exposure, antibiotics, and early dacryocystorhinostomy. Sparing technique was used in all operations, carried out under local anesthesia with 2% procaine or trimecaine. IMF exposure was found to be an effective therapeutic means characterized by antiinflammatory, resolving, and analgesic effects. IMF sessions and early dacryocystorhinostomy enhance cessation of inflammation and improve the treatment efficacy: remote results of surgery were excellent in 80% of Group 1 patients and in 90.9% of Group 2 patients; As a results of IMF exposure, the terms of medical and social rehabilitation of patients with the lacrimal sac phlegmons were reduced twofold. PMID:1481321

Sultanov, M Iu; Iskenderov, G F; Tagi-zade, N S; Seidbekov, O S

1992-01-01

304

Phospholipid composition of Rickettsia prowazeki grown in chicken embryo yolk sacs.  

PubMed Central

The phospholipid composition and phospholipid fatty acid composition of purified Rickettsia prowazeki were determined. The lipid phosphorous content was 6.8 +/- 1.3 microgram/mg of total rickettsial protein. The major phospholipid was phosphatidylethanolamine (60 to 70%); phosphatidylglycerol constituted 20%, and phosphatidylcholine constituted 15%. Small amounts of phosphatidylserine and cardiolipin were detected. The principal fatty acids were 18:1, 16:1, and 16:0. The fatty acid composition of the phosphatidylcholine in the rickettsial extracts was very different than that of the other rickettsial phosphatides and very similar to that of normal yolk sac phosphatidylcholine. The specific of the phosphatidylcholine of rickettsiae grown in the presence of 32P was markedly lower than that of phosphatidylethanolamine and phosphatidylglycerol. It is suggested that the phosphatidylcholine in the rickettsial extract is yolk sac derived and either tightly absorbed or exchanged into the rickettsial membrane.

Winkler, H H; Miller, E T

1978-01-01

305

Sac3, an Snf1-like serine/threonine kinase that positively and negatively regulates the responses of Chlamydomonas to sulfur limitation.  

PubMed Central

The Sac3 gene product of Chlamydomonas positively and negatively regulates the responses of the cell to sulfur limitation. In wild-type cells, arylsulfatase activity is detected only during sulfur limitation. The sac3 mutant expresses arylsulfatase activity even when grown in nutrient-replete medium, which suggests that the Sac3 protein has a negative effect on the induction of arylsulfatase activity. In contrast to its effect on arylsulfatase activity, Sac3 positively regulates the high-affinity sulfate transport system-the sac3 mutant is unable to fully induce high-affinity sulfate transport during sulfur limitation. We have complemented the sac3 mutant and cloned a cDNA copy of the Sac3 gene. The deduced amino acid sequence of the Sac3 gene product is similar to the catalytic domain of the yeast Snf1 family of serine/threonine kinases and is therefore classified as a Snf1-related kinase (SnRK). Specifically, Sac3 falls within the SnRK2 subfamily of kinases from vascular plants. In addition to the 11 subdomains common to Snf1-like serine/threonine kinases, Sac3 and the plant kinases have two additional subdomains and a highly acidic C-terminal region. The role of Sac3 in the signal transduction system that regulates the responses of Chlamydomonas to sulfur limitation is discussed.

Davies, J P; Yildiz, F H; Grossman, A R

1999-01-01

306

Tumor initiating cells.  

PubMed

Cancer Stem cells (CSC) are defined as a population of cells found within a tumor that have characteristics similar to normal stem cells. Like normal stem cells they have the potential to self renew and differentiate. The cellular origin of these cancer stem cells--whether they originate from stem cells that have lost the ability to regulate proliferation, or they arise from more differentiated population of progenitor cells that have acquired abilities to self-renew is still unclear. Investigators have reported isolation of cancer stem cells or tumor initiating cells using techniques developed for isolating hematopoietic stem cells and assays that identify a small subset of tumor initiating cells. The TICs are thought to play an important role in tumor development, progression as well response to therapy and relapse. Strategies that combine conventional therapies with newer approaches that target the TICs may be more effective in tumor cell kill are discussed. PMID:19199951

Bansal, Nitu; Banerjee, Debabrata

2009-02-01

307

Macrofauna community inside and outside of the Darwin Mounds SAC, NE Atlantic  

NASA Astrophysics Data System (ADS)

Over the past two decades, growing concerns have been raised regarding the effects of towed fishing gears, such as trawls and dredges, on deep-sea biodiversity and ecosystem functioning. Trawling disturbs the benthic communities both physically and biologically, and can eliminate the most vulnerable organisms and modify habitat structure; chronically disturbed communities are often dominated by opportunistic species. The European Union is under obligation to designate a network of offshore Special Areas of Conservation (SACs) and Marine Protected Areas (MPAs) by the end of 2012 based on the perceived expectation that these networks will help protect marine biodiversity and that within these areas, faunal abundance and diversity will be higher than the surrounding fished areas. The Darwin Mounds, only discovered in 1998, are located in the Rockall Trough, NE Atlantic at a depth of ~ 1000 m. Deep-water trawling regularly took place in the region of the Darwin Mounds; however in 2004 the mounds were designated as the first offshore SAC in UK and the area is now closed to bottom trawling. As part of the HERMIONE programme the influence of human impact on the Oceans was one of the key themes and in June 2011, an investigation of the macrofaunal community structure at comparable sites both inside and outside of the Darwin Mound SAC was undertaken. Macrofaunal communities were found to differ significantly, with the difference mostly driven by changes in the abundance of polychaetes, crustaceans and nematodes whilst no significant differences were seen for the other phyla. Whereas overall macrofaunal abundance was higher outside the SAC compared to within, this pattern varies considerably between phyla. Diversity indices showed no significant differences between protected and unprotected sites. This could indicate that a few years of preservation are not enough time to determine a recovery by the macrofaunal community of cold-water ecosystems and that a continued monitoring over a longer term is necessary to fully understand the impact of fishery closures.

Serpetti, N.; Gontikaki, E.; Narayanaswamy, B. E.; Witte, U.

2012-11-01

308

KNApSAcK Metabolite Activity Database for retrieving the relationships between metabolites and biological activities.  

PubMed

Databases (DBs) are required by various omics fields because the volume of molecular biology data is increasing rapidly. In this study, we provide instructions for users and describe the current status of our metabolite activity DB. To facilitate a comprehensive understanding of the interactions between the metabolites of organisms and the chemical-level contribution of metabolites to human health, we constructed a metabolite activity DB known as the KNApSAcK Metabolite Activity DB. It comprises 9,584 triplet relationships (metabolite-biological activity-target species), including 2,356 metabolites, 140 activity categories, 2,963 specific descriptions of biological activities and 778 target species. Approximately 46% of the activities described in the DB are related to chemical ecology, most of which are attributed to antimicrobial agents and plant growth regulators. The majority of the metabolites with antimicrobial activities are flavonoids and phenylpropanoids. The metabolites with plant growth regulatory effects include plant hormones. Over half of the DB contents are related to human health care and medicine. The five largest groups are toxins, anticancer agents, nervous system agents, cardiovascular agents and non-therapeutic agents, such as flavors and fragrances. The KNApSAcK Metabolite Activity DB is integrated within the KNApSAcK Family DBs to facilitate further systematized research in various omics fields, especially metabolomics, nutrigenomics and foodomics. The KNApSAcK Metabolite Activity DB could also be utilized for developing novel drugs and materials, as well as for identifying viable drug resources and other useful compounds. PMID:24285751

Nakamura, Yukiko; Afendi, Farit Mochamad; Parvin, Aziza Kawsar; Ono, Naoaki; Tanaka, Ken; Hirai Morita, Aki; Sato, Tetsuo; Sugiura, Tadao; Altaf-Ul-Amin, Md; Kanaya, Shigehiko

2014-01-01

309

First trimester three-dimensional ultrasound volumetry of the gestational sac  

Microsoft Academic Search

Summary  First trimester amniotic fluid is an ultrafiltrate of maternal plasma and constitutes the major component of gestational sac\\u000a volume (GSV). We hypothesized that GSV, assessed by 3-dimensional (3-D) ultrasound volumetry, would reflect function of the\\u000a early uteroplacental unit and therefore provide a basis for predicting pregnancy outcome. We tested this hypothesis in 38\\u000a pregnancies which had first trimester GSV measurements

H. Steinen; A. R. Gregg; G. Bogner; A. H. Graf; C. P. Weiner; A. Staudach

1994-01-01

310

Effect of cyclic fatigue damage accumulation on the elastic-plastic properties of SAC305 solders  

Microsoft Academic Search

This study examines the effect of cyclic damage on the constitutive response of Sn3.0Ag0.5Cu (SAC305) solder material. Cyclic damage is induced through isothermal, mechanical cycling tests at high strain rate and room temperature, using a modified lap-shear microscale specimen (180 mum wide solder joint). The elastic, plastic, and yield response of the cycled solder joints are measured as a function

Gayatri Cuddalorepatta; Abhijit Dasgupta

2009-01-01

311

Recurrent lacrimal sac rhinosporidiosis involving the periocular subcutaneous tissues, nasolacrimal duct and nasopharynx.  

PubMed

Rhinosporidiosis is a chronic infection caused by the organism Rhinosporidium seeberi. It is endemic in parts of southern India and Sri Lanka, but rarely seen outside these areas. The infection predominantly affects the nasal mucosa; however, it can also affect the ocular surface and adnexa. We present a case of rhinosporidiosis initially involving the lacrimal sac, with recurrence in the periocular subcutaneous tissues, nasolacrimal duct and nasopharynx. PMID:23030407

Rogers, Simon; Waring, Dale; Martin, Peter

2012-10-01

312

Gastrointestinal Stromal Tumors (GISTs) of the Stomach  

Microsoft Academic Search

Gastrointestinal stromal tumors (GISTs) are relatively rare tumors with an incidence of 5,000 to 10,000 cases per year in the United States. They are mesenchymal tumors arising from the interstitial cells of Cajal and are located within the submucosa of the GI tract. To differentiate from other submucosal lesions of the GI tract, the defining characteristic of GISTs is the

Joseph J. Bennett; Matthew S. Rubino

313

Adenocarcinoma Arising from Sacrococcygeal Mature Teratoma in an Adult Female: Report of a Case  

PubMed Central

We report a case of adenocarcinoma arising from a sacrococcygeal mature teratoma in an adult female. A 62-year-old female was diagnosed with a presacral tumor 10?years ago. Pelvic computed tomography (CT) demonstrated a presacral heterogeneous tumor, containing multiloculated cystic area and enhanced solid component with calcification. Percutaneous needle biopsy for the solid component of the tumor identified an adenocarcinoma and the patient was diagnosed as having a sacrococcygeal teratoma with malignant transformation. Abdomino-sacral rectal resection with sacral amputation at the upper edge of the S5 was performed. The pathological diagnosis was adenocarcinoma derived from a mature teratoma. The tumor cells had infiltrated the rectal wall. After 7?months, a follow-up CT demonstrated swelling of the right inguinal lymph nodes and a right inguinal lymphadenectomy was performed. Pathological examination showed metastatic lymph nodes. The patient is doing well 21?months after the second surgery, with no signs of recurrence.

Matsumoto, Naoki; Uehara, Keisuke; Ando, Masataka; Arimoto, Junki; Kato, Takehiro; Nakamura, Hayato; Ebata, Tomoki; Yokoyama, Yukihiro; Nagino, Masato

2014-01-01

314

Primary intracranial germ cell tumors  

PubMed Central

Background: Primary intracranial germ cell tumors are rare (ICGCTs) and usually localized in the pineal and suprasellar regions of the brain. They are divided into histologic types: Germinoma, teratoma choriocarcinoma, embryonal carcinoma, yolk sac tumor, and malignant mixed germ cell tumors (MMGCTs). Neuroimaging evaluation is useful to distinguish between the types of ICGCTs. Germinoma is highly sensitive to radiotherapy or/and chemotherapy, and is potentially curable without surgery. MMGCTs are treated with the combination of chemotherapy and radiation, with a poorer prognosis. ICGCTs warrant correct pre-operative diagnosis in order to decide on appropriate management. Aim: To report the clinicopathological and immunohistochemical findings in three cases of primary intracranial germ-cell tumor. Materials and Methods: Three cases of intracranial germ cell tumors inclusive of both genders and all brain regions were retrieved from the archives of the Anatomical Pathology Department at King Abdul Aziz University Hospital, Jeddah between the years, 1995-2011, through a computerized search. Results: Based on histological examination, they were respectively diagnosed as MMGCTs (two cases) and germinoma. Clinical, radiological, pathological characteristics and immunohistochemical profile of the three ICGCTs are presented along with the review of recent literature. Conclusion: ICGCTs are rare tumors affecting males more than females, and at the end of three years follow-up in the present study, treatment morbidity appears to be low with no recurrence observed among surviving patients, indicating that suprasellar and basal ganglia ICGCTs may have a favorable prognosis regardless of histological type. Pineal MMGCTs may have an aggressive course.

Mufti, Shagufta Tahir; Jamal, Awatif

2012-01-01

315

Evaluation of Refractivity Profiles From Champ and SAC-C GPS Radio Occultation  

NASA Technical Reports Server (NTRS)

The CHAMP and SAC-C missions are the first missions to carry a second-generation 'Blackjack' GPS receiver. One of the new features of this receiver is its ability to sense the lower troposphere closer to the surface than the proof-of-concept GPS/MET 1995 experiment. Since their launch, CHAMP and SAC-C have collected thousands of GPS radio occultations, representing a wealth of measurements available for data assimilation in Numerical Weather Prediction (NWP) models. In order to evaluate the refractivity data derived by JPL from raw radio occultation measurements, we use Data Assimilation Office (DAO) shout forecasts as an independent state of the atmosphere. We compare CHAMP and SAC-C refractivity (processed by JPL) with refractivity calculated from the DAO global fields of temperature, water vapor content and humidity. We will show statistics of the differences as well as Probability Density Functions (PDFs) of the differences. Depending upon availability of AIRS data, we plan to show individual profile comparisons between GPS radio occultation and AIRS retrievals.

Poli, Paul; Joiner, Joanna; delaTorreJuarez, Manuel; Hoff, Raymond M.; Atlas, Robert (Technical Monitor)

2002-01-01

316

Evaluation of Refractivity Profiles from CHAMP and SAC-C GPS Radio Occultation  

NASA Technical Reports Server (NTRS)

The GeoForschungsZentrum's Challenging Minisatellite Payload for Geophysical Research and Application (CHAMP, Germany-US) and the Comision Nacional de Actividades Especiales' Satelite de Aplicaciones Cientificas-C (SAC-C, Argentina-US) missions are the first missions to carry a second-generation Blackjack Global Positioning System (GPS) receiver. One of the new features of this receiver is its ability to sense the lower troposphere closer to the surface than the proof-of-concept GPS Meteorology experiment (GPS/MET). Since their launch, CHAMP and SAC-C have collected thousands of GPS radio occultations, representing a wealth of measurements available for data assimilation and Numerical Weather Prediction (NWP). In order to evaluate the refractivity data derived by the Jet Propulsion Laboratory (JPL) from raw radio occultation measurements, we use Data Assimilation Office (DAO) 6-hour forecasts as an independent state of the atmosphere. We compare CHAMP and SAC-C refractivity (processed by JPL) with refractivity calculated from the DAO global fields of temperature, water vapor content and humidity. We show statistics of the differences as well as histograms of the differences.

Poli, Paul; Ao, Chi On; Joiner, Joanna; delaTorreJuarez, Manuel; Hoff, Raymond

2002-01-01

317

Evaluation of Refractivity Profiles from CHAMP and SAC-C GPS Radio Occultation  

NASA Technical Reports Server (NTRS)

The CHAMP and SAC-C missions are the first missions to carry a second-generation 'Blackjack' GPS receiver. One of the new features of this receiver is its ability to sense the lower troposphere closer to the surface than the proof-of-concept GPS/MET 1995 experiment. Since their launch, CHAMP and SAC-C have collected thousands of GPS radio occultations, representing a wealth of measurements available for data assimilation in Numerical Weather Prediction (NWP) models. In order to evaluate the refractivity data derived by JPL from raw radio occultation measurements, we use Data Assimilation Office (DAO) 6-hour forecasts as an independent state of the atmosphere. We compare CHAMP and SAC-C refractivity (processed by JPL) with refractivity calculated from the DAO global fields of temperature, water vapor content and humidity. We will show statistics of the differences as well as Probability Density Functions (PDFs) of the differences. Depending upon availability of AIRS data, we plan to show individual profile comparisons between GPS radio occultation and AIRS retrievals.

Poli, Paul; Joiner, Joanna; delaTorreJuarez, Manuel; Hoff, Raymond M.; Atlas, Robert (Technical Monitor)

2002-01-01

318

Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb  

PubMed Central

Hematopoiesis initiates within the yolk sac of mammalian embryos in overlapping primitive and definitive waves, each containing erythroid and megakaryocyte progenitors. c-myb–null mouse fetuses lack definitive erythrocytes but contain primitive erythroblasts and hepatic megakaryocytes. However, it is unclear if c-myb–null embryos harbor definitive erythroid or any megakaryocyte progenitors. We determined that c-myb was not expressed in primitive erythroid precursors and that c-myb–null embryos had normal primitive erythroid and megakaryocyte progenitor numbers and kinetics between embryonic day (E) 7.0 and E9.0. While primitive hematopoiesis is c-myb–independent, no definitive erythroid potential was detected in c-myb–null embryos, confirming that definitive erythropoiesis, beginning at E8.25 in the yolk sac, is completely c-myb–dependent. In contrast, reduced numbers of megakaryocyte progenitors with restricted proliferative capacity persist in E10.5 yolk sac and E11.5 liver. Despite this impaired megakaryocyte potential, c-myb–null fetuses had normal platelet numbers at E12.5 but became thrombocytopenic by E15.5, suggesting that c-myb is required for sustained thrombopoiesis.

Tober, Joanna; McGrath, Kathleen E.

2008-01-01

319

Pathological, immunohistochemical and microbiologicalal analysis of lacrimal sac biopsies in patients with chronic dacrocystitis  

PubMed Central

AIM To analyze cases of obstruction of the nasolacrimal duct which creates a fertile environment for secondary bacterial infection and can result in dacryocystitis, which is a constant threat to cornea and orbital soft tissue and a potential source of endophthalmitis following intraocular surgery. The majority of obstructions of the lacrimal excretory outflow system are acquired ones occurring in adulthood and involving the distal parts of the system. Acquired obstruction may be primary/idiopathic or secondary to a wide variety of infectious, inflammatory, traumatic, mechanical, toxic or neoplastic causes mimicking idiopathic inflammation. These cases are treated by dacryocystorhinostomy (DCR). METHODS The present study was conducted to determine the histopathologic, immunohistochemical and current microbiologic characteristics of lacrimal sac specimens in patients undergoing external dacryocystorhinostomy. RESULTS Non-specific lacrimal sac pathology was present in all 33 cases and 81.8% of the cases showed moderate chronic inflammation with a chronic inflammatory score (CIS) ranging between 4 and 6, whereas 12.12% showed severe inflammatory changes with a CIS of 7. Mild degree of inflammation was seen in 6.06% with a CIS of 3. The total prevalence of gram-positive, gram-negative, and culture-negative samples were 59.4%, 37.5%, and 3% respectively. CONCLUSION Non-specific chronic inflammation with fibrosis is indeed the most commonly reported histopathological finding in lacrimal sac wall biopsy specimens.

Amin, Rowayda Mahmoud; Hussein, Faten Aly; Idriss, Hisham Farouk; Hanafy, Nesrine Fathy; Abdallah, Dina Mohamed

2013-01-01

320

The efficacy of sleeve technique in primary nasolacrimal duct obstruction with a high lacrimal sac  

PubMed Central

Purpose: To evaluate the efficacy of a sleeve technique during endoscopic dacryocystorhinostomy (DCR) in primary nasolacrimal duct obstruction (NLDO) patients with a high lacrimal sac. Materials and Methods: The medical records of 45 patients (49 cases) undergoing endoscopic DCR for primary NLDO with a high lacrimal sac were retrospectively reviewed. In 19 patients (21 cases), the thick maxilla covering the common canalicular opening was removed using a drill and a bicanalicular silicone tube was inserted (group 1). In 26 patients (28 cases), instead of removal of the thick maxilla, a sleeve was inserted into the bicanalicular silicone tube (group 2). At 6 months postoperatively, the success rate was evaluated and the size of the intranasal mucosal ostium was measured. Results: The success rates in group 1 and 2 was 90.5% and 96.4%, respectively (P =0.400). The intranasal mucosal ostium in group 1 and 2 measured 1.7 ± 0.7 mm and 3.1 ± 1.0 mm, respectively, and the difference was significant (P =0.042). Conclusions: In primary NLDO patients with a high lacrimal sac, DCR inserting a silicone tube and a sleeve together had a satisfactory success rate without using a drill. In comparison with traditional surgical methods, it helped enlarge the size of the intranasal mucosal ostium.

Kim, Kyoung-Nam; Lee, Yeon-Hee; Kim, Jung-Yeul; Lee, Sung-Bok

2014-01-01

321

Endolymphatic sac shunt, labyrinthectomy, and vestibular nerve section in Meniere's disease.  

PubMed

Medical treatment for Meniere's disease is effective in controlling vertigo for approximately 85% of patients. However, when disabling vertigo continues, surgical therapy is indicated. Several surgical approaches are performed to control the symptoms of peripheral vestibular disorders refractory to medical measures, each procedure having many technical variations. Surgery is usually reserved for patients with disabling vertigo. Here, the authors discuss surgical options for vertigo control in Meniere's disease and review the literature on outcomes of these management options. The authors discuss endolymphatic sac shunt (ie, endolymphatic mastoid shunt), vestibular nerve section, cochleosacculotomy, and labyrinthectomy. When looking at data based on patient ratings, the authors find that surgery improves vertigo in endolymphatic sac shunt, vestibular nerve section, and labyrinthectomy groups and improves imbalance for the endolymphatic sac shunt and vestibular nerve section groups. Labyrinthectomy and translabyrinthine vestibular nerve section both offer excellent control of intractable vertigo. However, patients undergoing translab yrinthine vestibular nerve section are more likely to show improvement in imbalance and functional disability. This outcome is more likely for diagnoses other than Meniere's disease. There are potential prognostic factors that can be helpful in the preoperative or postoperative counseling of patients undergoing surgical treatment of vertigo. Patients who rate themselves as more disabled before surgery are less likely to achieve the best outcomes. Several other factors, such as duration of disease, contralateral tinnitus, eye disease, and allergy, may play a role. PMID:20713247

Teufert, Karen B; Doherty, Joni

2010-10-01

322

A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry  

PubMed Central

Carcinomas rarely arise from the urethral diverticulum. In this report, we present a case of clear cell adenocarcinoma arising from the urethral diverticulum. A 42-year-old woman complained of bloody discharge and lower back pain. Imaging studies showed a tumor involving the region surrounding the urethra and cystourethroscopy showed papillary and villous tumors in the urethral diverticula. Cytology of the urine sediment showed papillary or spherical clusters of atypical cells, some of which had clear abundant cytoplasm and formed mirror ball-like clusters, suggesting adenocarcinoma. Although histological diagnosis was indeterminate by biopsy and transurethral resection (TUR) because of absence of stromal invasion, surgically resected specimen via cysturethrectomy revealed that the tumor was clear cell carcinoma. Urinary cytological findings and immunohistochemical analysis for CD15, Ki-67, and p53 might be useful for accurate diagnosis of clear cell adenocarcinoma that arises from the urethral diverticulum when sufficient materials are not available by biopsy and TUR.

Nakatsuka, Shin-ichi; Taguchi, Isao; Nagatomo, Tadasuke; Yamane, Michiaki; Sugio, Kenji; Yoshino, Ryuichi; Oku, Kazuko; Nagano, Teruaki; Kimura, Hayato; Nakajo, Kazuya; Kawabata, Gaku

2012-01-01

323

A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry.  

PubMed

Carcinomas rarely arise from the urethral diverticulum. In this report, we present a case of clear cell adenocarcinoma arising from the urethral diverticulum. A 42-year-old woman complained of bloody discharge and lower back pain. Imaging studies showed a tumor involving the region surrounding the urethra and cystourethroscopy showed papillary and villous tumors in the urethral diverticula. Cytology of the urine sediment showed papillary or spherical clusters of atypical cells, some of which had clear abundant cytoplasm and formed mirror ball-like clusters, suggesting adenocarcinoma. Although histological diagnosis was indeterminate by biopsy and transurethral resection (TUR) because of absence of stromal invasion, surgically resected specimen via cysturethrectomy revealed that the tumor was clear cell carcinoma. Urinary cytological findings and immunohistochemical analysis for CD15, Ki-67, and p53 might be useful for accurate diagnosis of clear cell adenocarcinoma that arises from the urethral diverticulum when sufficient materials are not available by biopsy and TUR. PMID:22615710

Nakatsuka, Shin-Ichi; Taguchi, Isao; Nagatomo, Tadasuke; Yamane, Michiaki; Sugio, Kenji; Yoshino, Ryuichi; Oku, Kazuko; Nagano, Teruaki; Kimura, Hayato; Nakajo, Kazuya; Kawabata, Gaku

2012-01-01

324

Cytogenetic analysis of a low-grade secondary peripheral chondrosarcoma arising in synovial chondromatosis.  

PubMed

Secondary chondrosarcoma is a malignant chondroid tumor arising in a benign precursor. Synovial chondromatosis is a benign chondroid lesion that rarely transforms to chondrosarcoma. We present the case of a 54-year-old male with the diagnosis of low-grade secondary peripheral chondrosarcoma developed in the context of synovial chondromatosis. Cytogenetics revealed a novel aberration t(1;14)(q23.1~24;q24.1~3). Multicolor banding (mBAND) analysis described the chromosomal regions involved in this translocation with a higher detail. Diagnosis of such borderline lesions is very difficult and cytogenetics is helpful in characterizing these tumors. PMID:23239852

Kyriazoglou, Anastasios I; Rizou, Helen; Dimitriadis, Efthimios; Arnogiannaki, Niki; Agnantis, Niki; Pandis, Nikos

2013-01-01

325

Desmoplastic medulloblastoma arising from an ovarian teratoma: a case report and review of the literature.  

PubMed

The primary neuroectodermal tumor of the ovary is extremely rare, and it manifests in 3 forms: differentiated, primitive, and anaplastic. The medulloblastoma belongs to the subgroup of primitive neuroectodermal tumor of the ovary. Only 3 cases of ovarian medulloblastoma have been reported in the literature, and all of them are presented without information about the specific pathological subtype. We present the fourth case of a 26-year-old woman who presented with abdominal fullness for months. Ultrasound exam showed a right adnexal mass with cystic feature and foci solid components. A partial oophorectomy was performed, and the mass was a desmoplastic medulloblastoma arising from an ovarian teratoma. PMID:23129837

Wey, Shiuan-Li; Chen, Chi-Kuan; Chen, Tze-Chien; Chen, Tung-Ying

2013-08-01

326

Successful Endoscopic Resection of Large Pedunculated Brunner's Gland Hamartoma Causing Gastrointestinal Bleeding Arising from the Pylorus  

PubMed Central

Brunner's gland hamartoma is a rare benign small bowel neoplasm and most lesions are small and asymptomatic. However, large hamartoma-related obstructive symptoms and hemorrhage related to tumor ulceration manifest as hematemesis or melena. The exact pathogenesis if these lesions is not well known, but they are thought to be frequently associated with Helicobacter pylori infections and chronic pancreatitis. We report the case of a 45-year-old man who presented with melena due to a large pedunculated Brunner's gland hamartoma arising from the pylorus. It was successfully removed by endoscopic mucosal resection with piecemeal technique because of too large tumor size for application of a conventional snare.

Jung, Yunho; Chung, Il Kwun; Lee, Tae Hoon; Cho, Young Sin; Jo, Yeong Geol; Park, Sang Heum; Cho, Hyundeuk; Kim, Sun Joo

2013-01-01

327

Adenocarcinoma arising from Meckel's diverticulum in the ileum with malrotation of the midgut  

PubMed Central

Meckel's diverticulum (MD) is a true congenital diverticulum that is remnant by incomplete obliteration of the omphalomesenteric duct. It is the most common congenital anomaly of the gastrointestinal tract, with an estimated prevalence of 2% (0.3% to 3% in autopsy studies). About 90% of MD occurs within 100 cm of the ileocecal valve. A primary malignant tumor arising within an MD is extremely uncommon. Malignancies are reported to account for only 0.5% to 3.2% of the complications. Carcinoids are the most common malignant tumors occurring in MD. Adenocarcinomas are extremely uncommon and very poor prognosis has been reported. We report a case of radiographically diagnosed chronic inflammatory mass caused by adenocarcinoma arising from MD in the ileum with malrotation of the midgut incidentally discovered at exploration.

Lee, Jin Kwon; Kwag, Seung Jin; Oh, Seong Taek; Kim, Jun Gi

2013-01-01

328

Chorioallantoic and yolk sac placentation in the dassie rat Petromus typicus and its significance for the evolution of hystricognath rodents.  

PubMed

Placental characters are most important in understanding the evolutionary history of hystricognath rodents of which some act as animal models for human pregnancy. The data available deal mostly with species native to South America, but the current paper presents novel findings on chorioallantoic and yolk sac placentation in an Old World hystricognath and discusses its significance for the evolution of the group. Several hystricognath stem species characters are verified for Petromus, such as the unique trophoblast growth pattern within the chorioallantoic placenta. Subsequently, a novel set of characters belonging to the visceral yolk sac is added to the stem species pattern of the group. The nourishment of the embryo is facilitated by an inverted visceral yolk sac placenta from early pregnancy onward, later complemented by the chorioallantoic placenta. About mid term, the visceral yolk sac becomes partly folded and attached to the parietal yolk sac cover of the chorioallantoic placenta, suggesting a functional shift to the transfer of substances between the two placental types. Thus, the chorioallantoic and yolk sac placenta collaborate in nurturing the embryo. This apparently represents an evolutionary transformation along the stem lineage of hystricognaths. PMID:17586042

Mess, A

2007-01-01

329

Cylindroma with Stromal Adipose Tissue Metaplasia versus Arising in a Background of Nevus Lipomatosus  

PubMed Central

Nevus lipomatosus superficialis is a rare type of connective tissue nevus. Cylindroma is a benign skin appendage tumor with a predilection for the scalp of older females. We describe the case of a 56-year-old woman with a scalp lesion demonstrating histopathologic features consistent with benign cylindroma arising within a nevus lipomatosus superficialis. To our knowledge, this lesion has not been raised in the literature in the differential for cylindroma with what is presumed to be stromal adipose metaplasia.

Yu, Ryan; Alowami, Salem

2014-01-01

330

Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors  

ClinicalTrials.gov

Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Childhood Choroid Plexus Tumor; Childhood Craniopharyngioma; Childhood Ependymoblastoma; Childhood Grade I Meningioma; Childhood Grade II Meningioma; Childhood Grade III Meningioma; Childhood High-grade Cerebellar Astrocytoma; Childhood High-grade Cerebral Astrocytoma; Childhood Infratentorial Ependymoma; Childhood Low-grade Cerebellar Astrocytoma; Childhood Low-grade Cerebral Astrocytoma; Childhood Medulloepithelioma; Childhood Mixed Glioma; Childhood Oligodendroglioma; Childhood Supratentorial Ependymoma; Extra-adrenal Paraganglioma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Spinal Cord Neoplasm; Recurrent Childhood Subependymal Giant Cell Astrocytoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Childhood Visual Pathway and Hypothalamic Glioma

2013-05-01

331

Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III ?-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation during mitosis.  

PubMed

Genomic instability and a predisposition to cancer are hallmarks of Bloom syndrome, an autosomal recessive disease arising from mutations in the BLM gene. BLM is a RecQ helicase component of the BLM-Topo III ?-RMI1-RMI2 (BTR) complex, which maintains chromosome stability at the spindle assembly checkpoint (SAC). Other members of the BTR complex include Topo IIIa, RMI1, and RMI2. All members of the BTR complex are essential for maintaining the stable genome. Interestingly, the BTR complex is posttranslationally modified upon SAC activation during mitosis, but its significance remains unknown. In this study, we show that two proteins that interact with BLM, RMI1 and RMI2, are phosphorylated upon SAC activation, and, like BLM, RMI1, and RMI2, are phosphorylated in an MPS1-dependent manner. An S112A mutant of RMI2 localized normally in cells and was found in SAC-induced coimmunoprecipitations of the BTR complex. However, in RMI2-depleted cells, an S112A mutant disrupted the mitotic arrest upon SAC activation. The failure of cells to maintain mitotic arrest, due to lack of phosphorylation at Ser-112, results in high genomic instability characterized by micronuclei, multiple nuclei, and a wide distribution of aberrantly segregating chromosomes. We found that the S112A mutant of RMI2 showed defects in redistribution between the nucleoplasm and nuclear matrix. The phosphorylation at Ser-112 of RMI2 is independent of BLM and is not required for the stability of the BTR complex, BLM focus formation, and chromatin targeting in response to replication stress. Overall, this study suggests that the phosphorylation of the BTR complex is essential to maintain a stable genome. PMID:24108125

Pradhan, Arun; Singh, Thiyam Ramsing; Ali, Abdullah Mahmood; Wahengbam, Kebola; Meetei, Amom Ruhikanta

2013-11-22

332

Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs)  

SciTech Connect

Highlights: {yields} Endothelin-1 expression by adult rat astrocytes correlates with cell proliferation. {yields} Stretch-induced ET-1 is inhibited by GsMtx-4, a specific inhibitor of Ca{sup 2+} permeant SACs. {yields} The less specific SAC inhibitor streptomycin also inhibits ET-1 secretion. {yields} Stretch-induced ET-1 production depends on a calcium influx. {yields} SAC pharmacology may provide a new class of therapeutic agents for CNS pathology. -- Abstract: The expression of endothelins (ETs) and ET-receptors is often upregulated in brain pathology. ET-1, a potent vasoconstrictor, also inhibits the expression of astrocyte glutamate transporters and is mitogenic for astrocytes, glioma cells, neurons, and brain capillary endothelia. We have previously shown that mechanical stress stimulates ET-1 production by adult rat astrocytes. We now show in adult astrocytes that ET-1 production is driven by calcium influx through stretch-activated ion channels (SACs) and the ET-1 production correlates with cell proliferation. Mechanical stimulation using biaxial stretch (<20%) of a rubber substrate increased ET-1 secretion, and 4 {mu}M GsMTx-4 (a specific inhibitor of SACs) inhibited secretion by 30%. GsMTx-4 did not alter basal ET-1 levels in the absence of stretch. Decreasing the calcium influx by lowering extracellular calcium also inhibited stretch-induced ET-1 secretion without effecting ET-1 secretion in unstretched controls. Furthermore, inhibiting SACs with the less specific inhibitor streptomycin also inhibited stretch-induced ET-1 secretion. The data can be explained with a simple model in which ET-1 secretion depends on an internal Ca{sup 2+} threshold. This coupling of mechanical stress to the astrocyte endothelin system through SACs has treatment implications, since all pathology deforms the surrounding parenchyma.

Ostrow, Lyle W., E-mail: lostrow1@jhmi.edu [Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205 (United States); Suchyna, Thomas M.; Sachs, Frederick [Department of Physiology and Biophysical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States)] [Department of Physiology and Biophysical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States)

2011-06-24

333

Multiple Roles for the Wilms' Tumor Suppressor, WT11  

Microsoft Academic Search

Wihns' tumor is a childhood kidney tumor that is a striking example of the way that cancer may arise through development gone awry. A pro- portion of these tumors develop as a result of the loss of function muta- tions in the Wilms' tumor suppressor gene, WT1. Inherited mutations in the WT1 gene can lead to childhood kidney cancer, severe

Rachel Davies; Adrian Moore; Andreas Schedl; Eva Bratt; Kiyoshi Miyahawa; Michael Ladomery; Colin Miles; Aswin Menke; Veronica van Heyningen; Nicholas Hastie

334

Selection of a management strategy for pediatric brainstem tumors  

Microsoft Academic Search

Brainstem tumors arise in portions of the rhombencephalon and mesencephalon. Some authorities include diencephalic tumors in this group. We have reviewed our clinical experience of 69 children (less than 21 years of age) with brainstem tumors evaluated and treated at Duke University Medical Center (DUMC) from 1960 to 1986. There were 19 patients with group 1 tumors (thalamus, third ventricle

Edward C. Halperin; Stanley M. Wehn; Janice W. Scott; William Djang; W. Jerry Oakes; Henry S. Friedman

1989-01-01

335

Lobular intraepithelial neoplasia arising within breast fibroadenoma  

PubMed Central

Background Fibroadenomas are the second most common breast pathology occurring in young women under the age of 35 years old. Fibroadenomas can be classified as simple or complex according to histological features. Complex fibroadenomas differ from simple fibroadenomas because of the presence of cysts (3 mm), sclerosing adenosis, epithelial calcifications, or papillary apocrine changes. Most fibroadenomas are clinically identifiable. In 25% of cases, fibroadenomas are non-palpable and are diagnosed with mammography and ultrasound. Differential diagnosis with well differentiated breast cancer is often necessary, particularly with medullary or mucinous tumors. Calcification findings within fibroadenomas by mammogram have to be investigated. The age of a lump is usually reflected by calcifications. Microcalcification can hide foci of carcinoma in situ when they are small, branching type, and heterogeneous. However, many morphological possibilities may not be reliable for deciding whether a certain calcification is the product of a malignant or a benign process. From a radiological point of view, fibroadenomas containing foci of carcinoma in situ can be indistinguishable from benign lesions, even if the incidence of carcinoma within fibroadenomas is estimated as 0.1–0.3%, and it could be a long-term risk factor for invasive breast cancer. Case presentation A 44-year-old woman presented with a 1.5-cm palpable, smooth, mobile lump in the lower-inner quadrant of her right breast. Standard mediolateral oblique and craniocaudal mammograms showed a cluster of eccentric popcorn-like calcifications within the fibroadenoma. After lumpectomy, a definitive histological examination confirmed the intra-operative diagnosis of a benign mass. However, lobular intraepithelial neoplasia foci were found, surrounded by atypical lobular hyperplasia. Conclusions The possibility of an old benign breast lump might be supported by fine needle aspiration biopsy or core biopsy before initiating follow-up. According to our experience, when patients are older than 40 years and have a familial history of breast cancer, we prefer to carry out lumpectomy with follow up to avoid the risk of underestimation in situ foci within the lump.

2013-01-01

336

Desmoid Tumor of the Paraspinous Muscle.  

National Technical Information Service (NTIS)

Desmoid tumors of the chest wall are rare lesions with those which involve the paraspinous muscle being particularly rare. This report presents a case of successful resection of a desmoid arising in the right paraspinous muscle. A large ipsilateral latiss...

G. M. Graeber

1985-01-01

337

Yolk sac tumour of the penile shaft: a rare primary extra-gonadal presentation.  

PubMed

Germ cell tumours (GCTs) commonly involve the ovaries, testes, and other midline structures in children and adolescents and comprised a variety of tumours that have a common histiogenetic origin. The yolk sac tumour (YST) variant is the most common one seen in over 80% of testicular GCTs in children. Other sites of occurrence of these tumours include the mediastinum, prostate, retroperitoneum, and sacrococcygeal region. Penile malignancies account for less than 10% of male malignancies in the elderly, while its occurrence in children is rare. We present the case of a 5-year-old child with YST of the penile shaft and uninvolved testes. PMID:22005377

Samaila, Modupeola Omotara; Maitama, Hussaini Y; Abdullahi, Kabiru; Mbibu, Hyacinth; Waziri, Garba Dahiru

2011-01-01

338

Water quality in the Little Sac River basin near Springfield, Missouri, 1999-2001  

USGS Publications Warehouse

The Little Sac River, north of Springfield, Missouri, flows through mainly agricultural and forest land. However, the quality of the river water is a concern because the river flows into Stockton Lake, which is a supplemental drinking water source for Springfield. Large bacterial densities and nutrient concentrations are primary concerns to the water quality of the river.A 29-river mile reach of the Little Sac River is on the 1998 list of waters of Missouri designated under section 303(d) of the Federal Clean Water Act because of fecal coliform densities larger than the Missouri Department of Natural Resources standard (hereinafter referred to as Missouri standard) of 200 colonies per 100 milliliters for whole-body contact recreation. During an investigation of the water quality in the Little Sac River by the U.S. Geological Survey, in cooperation with the Watershed Committee of the Ozarks, fecal coliform bacteria densities exceeded the Missouri standard (the standard applies from April 1 through October 31) in one sample from a site near Walnut Grove. At other sites on the Little Sac River, the Missouri standard was exceeded in two samples and equalled in one sample upstream from the Northwest Wastewater Treatment Plant (NW WTP) and in one sample immediately downstream from the NW WTP.Effluent from the NW WTP flows into the Little Sac River. Annually from April 1 through October 31, the effluent is disinfected to meet the Missouri standard for whole-body contact recreation. Fecal coliform bacteria densities in samples collected during this period generally were less than 100 colonies per 100 milliliters. For the rest of the year when the effluent was not disinfected, the bacteria densities in samples ranged from 50 (sample collected on November 1, 2000) to 10,100 colonies per 100 milliliters (both counts were non-ideal). When the effluent was disinfected and the fecal coliform bacteria density was small, samples from sites upstream and downstream from the NW WTP had a bacteria density larger than the density in the effluent. Other sources of bacteria are likely to be present in the study area in addition to the NW WTP. These potential sources include effluent from domestic septic systems and animal wastes.Nutrient concentrations in the Little Sac River immediately downstream from the NW WTP were affected by effluent from the NW WTP and possibly other sources. At two sites upstream from the NW WTP, median nitrite plus nitrate concentrations were 1.1 and 1.4 milligrams per liter. The median nitrite plus nitrate concentration for the effluent from the NW WTP was 6.4 milligrams per liter, and the median concentration decreased downstream in the Little Sac River to 2.2, 1.2, and 0.56 milligrams per liter.The effects of the effluent from the NW WTP on the water quality of the Little Sac River downstream from the NW WTP were reflected in an increase in discharge (effluent from the NW WTP can be as much as 50 percent of the flow at the site about 1.5 river miles downstream from the NW WTP), an increase in specific conductance values, an increase in several inorganic constituent concentrations, including calcium, magnesium, and sulfate, and a large increase in sodium and chloride concentrations. The effluent from the NW WTP seemed to have no effect on the pH value, temperature, and dissolved oxygen concentrations in the Little Sac River.Results of repetitive element polymerase chain reaction (rep-PCR) pattern analysis indicated that most Escherichia coli (E. coli) bacteria in water samples probably were from nonhuman sources, such as horses and cattle. The rep-PCR pattern analysis indicated that horses were an important source of E. coli downstream from the NW WTP, which was consistent with horses pastured adjacent to the sampling site. Fecal coliform bacteria loads increased upstream from the NW WTP from the most upstream site to the site immediately upstream from the NW WTP. Loads in the effluent from the NW WTP and also tho

Smith, Brenda J.

2002-01-01

339

Primary malignant lymphoma arising in the pleura without preceding long-standing pyothorax.  

PubMed

We report a very rare case of primary malignant lymphoma arising in the pleura with no history of persistent pyothorax. A 72-year-old male was hospitalized with dyspnea on effort and chest CT demonstrated a mass along the right chest wall. Right thoracotomy with complete en bloc resection of the pleural tumor was performed. Immunohistochemical examination of the pleural tumor showed that the histology was marginal zone B-cell malignant lymphoma. We considered that this tumor had originated from the soft tissue in the chest wall based on radiographical and surgical findings. As diagnosis and treatment of pleural malignant lymphoma seems to have been difficult in most cases reported in the literature, it is thought that early active and accurate biopsy with large-bore needles, or, if possible, surgical incision for early diagnosis and aggressive surgery to achieve complete resection combined with radiation therapy and/or chemotherapy would be very important for a good prognosis. PMID:15563266

Hirai, Shinji; Hamanaka, Yoshiharu; Mitsui, Norimasa; Morifuji, Kiyohiko; Sutoh, Miwa

2004-10-01

340

Embryo Sac Development in the Maize indeterminate gametophyte1 Mutant: Abnormal Nuclear Behavior and Defective Microtubule Organization.  

PubMed Central

The indeterminate gametophyte1 mutation in maize has been known to disrupt development of the female gametophyte. Mutant embryo sacs have abnormal numbers and behavior of micropylar and central cell nuclei, which result in polyembryony and elevated ploidy levels in the endosperm of developing kernels. In this study, we confirm abnormal nuclear behavior and present novel findings. In contrast to the normal form, there is no obvious polarity in two-nucleate embryo sacs or in the micropylar cells of eight-nucleate embryo sacs. We show that the second and third mitoses are not fully synchronized and that additional mitoses can occur in all of the nuclei of the mutant embryo sac or in just the micropylar or central regions. After cellularization, individual micropylar cells can undergo mitosis. Abnormal microtubular behavior results in irregular positioning of the nuclei, asynchronous microtubular patterns in different pairs of nuclei, and abnormal phragmoplasts after the third mitotic division. These results indicate that in addition to acting primarily in controlling nuclear divisions, the indeterminate gametophyte1 gene acts secondarily in regulating microtubule behavior. This cytoskeletal activity most likely controls the polarization and nuclear migration underlying the formation and fate of the cells of the normal embryo sac.

Huang, B. Q.; Sheridan, W. F.

1996-01-01

341

Peripheral Nerve Tumors  

Microsoft Academic Search

\\u000a Peripheral nerve tumors (PNTs) are rare soft tissue lesions that can arise anywhere on the body and as a result have a wide\\u000a differential diagnosis, which is often confirmed to be a PNT only at surgery. PNTs occur both sporadically and within the\\u000a context of genetically predisposing syndromes; hence, a thorough history of the mass and associated symptoms, with a

Joseph Wiley; Asis Kumar Bhattacharyya; Gelareh Zadeh; Patrick Shannon; Abhijit Guha

342

Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst - a clinicopathologic analysis of 116 reported cases  

Microsoft Academic Search

Purpose: To review the literature on primary intraosseous squamous cell carcinoma (PIOSCC) associated with odontogenic cyst. Methods: All well-documented cases of PIOSCC published between 1938 and 2010 were collected. Only cases of PIOSCC arising from the lining of an odontogenic cyst, including the keratocystic odontogenic tumor, were selected. Age, sex, signs and symptoms, affected jaw, cyst type, treatment, histopathology, and

L. Bodner; E. Manor; M. Shear; Waal van der I

2011-01-01

343

Cloning structural gene sacB, which codes for exoenzyme levansucrase of Bacillus subtilis: expression of the gene in Escherichia coli.  

PubMed Central

A clone bearing the structural gene sacB, coding for the exoenzyme levansucrase, was isolated from a library of Bacillus subtilis DNA that was cloned in phage lambda charon 4A on the basis of the transforming activity of the chimeric DNA. This lambda clone also was found to contain the sacR and smo loci. Subcloning the sacB-sacR region in plasmid pBR325 resulted in a clone which directed levansucrase synthesis in Escherichia coli. The nucleotide sequence coding for the secreted protein was localized on the physical map of the cloned DNA. Images

Gay, P; Le Coq, D; Steinmetz, M; Ferrari, E; Hoch, J A

1983-01-01

344

Developmental regulation of yolk sac hematopoiesis by Kr?ppel-like factor 6  

PubMed Central

Krüppel-like factor 6 (KLF6) is a member of a growing family of transcription factors that share a common 3 C2H2 zinc finger DNA binding domain and have broad activity in regulating proliferation and development. We have previously established that Klf6 is expressed in neuronal tissue, hindgut, heart, lung, kidney, and limb buds during midgestation. To explore the potential role of Klf6 in mouse development, we analyzed Klf6-/- mice and found that the homozygous mutation is embryonic lethal by embryonic day (E) 12.5 and associated with markedly reduced hematopoiesis and poorly organized yolk sac vascularization. Additionally, mRNA levels of Scl and Gata1 were reduced by approximately 80% in Klf6-/- yolk sacs. To further analyze this phenotype, we generated Klf6-/- embryonic stem (ES) cells by homologous recombination, and compared their capacity to differentiate into the hematopoietic lineage with that of either Klf6+/- or Klf6+/+ ES cells. Consistent with the phenotype in the early embryo, Klf6-/- ES cells displayed significant hematopoietic defects following differentiation into EBs. Prolongation of epiblast-like cells and delays in mesoderm induction were also observed in the Klf6-/- EBs, associated with delayed expression of Brachyury, Klf1, and Gata1. Forced expression of KLF6 using a tet-inducible system enhanced the hematopoietic potential of wild-type EBs. Collectively, these findings implicate Klf6 in ES-cell differentiation and hematopoiesis.

Matsumoto, Nobuyuki; Kubo, Atsushi; Liu, Huixian; Akita, Kuniharu; Laub, Friedrich; Ramirez, Francesco; Keller, Gordon; Friedman, Scott L.

2006-01-01

345

Comparative Analysis and Functional Mapping of SACS Mutations Reveal Novel Insights into Sacsin Repeated Architecture  

PubMed Central

Autosomal recessive spastic ataxia of Charlevoix–Saguenay (ARSACS) is a neurological disease with mutations in SACS, encoding sacsin, a multidomain protein of 4,579 amino acids. The large size of SACS and its translated protein has hindered biochemical analysis of ARSACS, and how mutant sacsins lead to disease remains largely unknown. Three repeated sequences, called sacsin repeating region (SRR) supradomains, have been recognized, which contribute to sacsin chaperone-like activity. We found that the three SRRs are much larger (?1,100 residues) than previously described, and organized in discrete subrepeats. We named the large repeated regions Sacsin Internal RePeaTs (SIRPT1, SIRPT2, and SIRPT3) and the subrepeats sr1, sr2, sr3, and srX. Comparative analysis of vertebrate sacsins in combination with fine positional mapping of a set of human mutations revealed that sr1, sr2, sr3, and srX are functional. Notably, the position of the pathogenic mutations in sr1, sr2, sr3, and srX appeared to be related to the severity of the clinical phenotype, as assessed by defining a severity scoring system. Our results suggest that the relative position of mutations in subrepeats will variably influence sacsin dysfunction. The characterization of the specific role of each repeated region will help in developing a comprehensive and integrated pathophysiological model of function for sacsin.

Romano, Alessandro; Tessa, Alessandra; Barca, Amilcare; Fattori, Fabiana; Fulvia de Leva, Maria; Terracciano, Alessandra; Storelli, Carlo; Santorelli, Filippo Maria; Verri, Tiziano

2013-01-01

346

Incidental finding of a malignant tumour in an inguinal hernia sac  

PubMed Central

Metastatic carcinomas in hernial sacs are rare, especially in bilateral femoral hernias. Here we describe a 63-year-old female patient with metastatic carcinoma in bilateral femoral hernias. She was diagnosed incidentally during femoral hernioplasty. A diagnostic laparoscopy revealed metastatic nodules in the abdominal cavity. Subsequently, the patient underwent a laparotomy that did not show any evidence of primary lesions. A chemotherapeutic pump was implanted into the abdominal cavity during surgery for postoperative chemotherapy. The chemotherapy regimen included 5-Fu, hydroxycamptothecin, and pirarubicin, supplemented with high agglomerative staphylococcin. Forty-one months after surgery her disease was stable and no abdominal cavity, pelvis, liver or lung metastases were observed. Therefore, we suggest that abnormal hernial sacs may be the first clue to an underlying cancer, and should be sent for histological examination. Furthermore, if a patient is found to have metastatic abdominal cancer with no evidence of primary lesions, they would probably benefit from postoperative chemotherapy. This can be delivered using a chemotherapeutic pump implanted during surgery.

Qin, Rong; Zhang, Qiaoyu; Weng, Jianfeng

2014-01-01

347

The Importance of Gestational Sac Size of Ectopic Pregnancy in Response to Single-Dose Methotrexate  

PubMed Central

This retrospective cohort study was designed in a selective group of 185 patients diagnosed with and treated for ectopic pregnancy. Intramuscular administration of a single dose of methotrexate (50?mg/m2) was performed to measure predictors of failure or resistance to treatment necessitating surgical intervention. During the time of treatment with a single dose of MTX, 20 patients (10.8%) failed to response, in which 6 of 20 (30%) indicated side effects to MTX and rupture of the ectopic pregnancy. Remaining cases (n = 14) showed resistance to the drug; the level of ?-hCG did not fall at least 15% during 7 days after treatment and necessitated laparotomy. In backward-step analysis by multiple logistic regressions of various types of predictor factors, size of gestational sac (coefficient = 1.91, OR = 6.78, 95% confidence interval = 3.18–8.22) and baseline level ?-hCG (coefficient = 1.60, OR = 5.0, 95% confidence interval = 4.26–6.72) had significant correlation with leading EP patients failing to response to MTX. This study suggests that further investigation for finding relative contraindications of MTX treatment in EP women should be considered on the gestational sac size because other variables are in the causal pathway of this variable.

Kimiaei, Parichehr; Khani, Zahra; Marefian, Azadeh; Gholampour Ghavamabadi, Maryam; Salimnejad, Maryam

2013-01-01

348

A novel approach for noninvasive drug delivery and sensing through the amniotic sac.  

PubMed

Current invasive prenatal tests (amniocentesis and chorionic villus sampling) are known for their risk to the fetus. In the last decade, the use and awareness of these prenatal tests have increased, resulting in growing demand for a safe, non-invasive, and accurate prenatal test. Chemical penetration enhancers (CPEs) have long been used to increase transport phenomena across skin and other membranes (e.g., tympanic membrane). The amniotic sac membrane is called the chorioamnion (CA) membrane and serves as the physical barrier between the fetus and the mother. In this research, the effect of CPEs on human CA mass transport was evaluated both in vitro and ex vivo. The results show that the tested CPEs exhibit an enhancing effect on CA mass transport. Based on the permeability results, two mechanisms of action were suggested: "extractors" and "fluidizers". Fourier transform infrared (FTIR) and rapid colorimetric screening measurements supported the mechanisms, based on which, more potent compounds were designed and tested for their enhancing effect. The enhancing mass transport effect of CPEs on CA membrane may be used both for sampling of cell-free DNA and for noninvasively administering drugs and other biological agents to the amniotic sac. PMID:24685707

Azagury, Aharon; Amar-Lewis, Eliz; Mann, Ella; Goldbart, Riki; Traitel, Tamar; Jelinek, Raz; Hallak, Mordechai; Kost, Joseph

2014-06-10

349

Automatic registration of terrestrial point clouds based on panoramic reflectance images and efficient BaySAC  

NASA Astrophysics Data System (ADS)

This paper presents a new approach to automatic registration of terrestrial laser scanning (TLS) point clouds utilizing a novel robust estimation method by an efficient BaySAC (BAYes SAmpling Consensus). The proposed method directly generates reflectance images from 3D point clouds, and then using SIFT algorithm extracts keypoints to identify corresponding image points. The 3D corresponding points, from which transformation parameters between point clouds are computed, are acquired by mapping the 2D ones onto the point cloud. To remove false accepted correspondences, we implement a conditional sampling method to select the n data points with the highest inlier probabilities as a hypothesis set and update the inlier probabilities of each data point using simplified Bayes' rule for the purpose of improving the computation efficiency. The prior probability is estimated by the verification of the distance invariance between correspondences. The proposed approach is tested on four data sets acquired by three different scanners. The results show that, comparing with the performance of RANSAC, BaySAC leads to less iterations and cheaper computation cost when the hypothesis set is contaminated with more outliers. The registration results also indicate that, the proposed algorithm can achieve high registration accuracy on all experimental datasets.

Kang, Zhizhong

2013-10-01

350

Les rivie?res et les sources de la Plaine du Cul-de-Sac: extrait du rapport sur les eaux souterraines de la Plaine du Cul-de-Sac  

USGS Publications Warehouse

Les principales rivières de la Plaine du Cul-de-Sac, la Rivière Grise ou Grande Rivière du Cul-de-Sac et la Rivière Blanche, prennent naissance sur le flanc Nord du Massif de la Selle à des altitudes de 1,300 à 1,800 mètres au dessus du niveau de la mer. Elles coulent à l’amont à travers des gorges profondes et sont éloignées de 9 Kms. dans la partie central de la bordure Sud de la plaine.

Taylor, George C., Jr.; Lemoine, Rémy C.

1949-01-01

351

Chemically intuitive indices for charge-transfer excitation based on SAC-CI and TD-DFT calculations.  

PubMed

A recently proposed charge-transfer (CT) index and some related quantities aimed to the description of CT excitations in push-pull donor-acceptor model systems were computed in vacuum and in ethanol by the direct symmetry-adapted cluster-configuration interaction (SAC-CI) method including solvent effects by means of the nonequilibrium state-specific approach. The effects of both solvation and electron correlations on these quantities were found to be significant. The present results are also in line with previous time-dependent (TD) density functional theory calculations and they demonstrate that SAC-CI provides a description of the excitation character close to that of TD-PBE0. Indeed, CT indices evaluated by the SAC-CI and TD-PBE0 would be useful in the field of materials chemistry, for the design and development of novel molecular materials. PMID:24037799

Ehara, Masahiro; Fukuda, Ryoichi; Adamo, Carlo; Ciofini, Ilaria

2013-11-01

352

Characteristics of indomethacin-saccharin (IMC-SAC) co-crystals prepared by an anti-solvent crystallization process.  

PubMed

The creation of co-crystals of various insoluble drug substances has been extensively investigated as a promising approach to improve their pharmaceutical performance. In this study, co-crystal powders of indomethacin and saccharin (IMC-SAC) were prepared by an anti-solvent (water) addition and compared with co-crystals by evaporation method. No successful synthesis of a pharmaceutical co-crystal powder via an anti-solvent approach has been reported. Among solvents examined, methanol was practically the only one that resulted in the formation of highly pure IMC-SAC co-crystal powders by anti-solvent approach. The mechanism of a preferential formation of IMC-SAC co-crystal to IMC was explained with two aspects: phase solubility diagram and solution complexation concept. Accordingly, the anti-solvent approach can be considered as a competitive route for producing pharmaceutical co-crystal powders with acceptable properties. PMID:23454054

Chun, Nan-Hee; Wang, In-Chun; Lee, Min-Jeong; Jung, Yun-Taek; Lee, Sangkil; Kim, Woo-Sik; Choi, Guang J

2013-11-01

353

The Role of Elastic and Plastic Anisotropy of Sn in Recrystallization and Damage Evolution During Thermal Cycling in SAC305 Solder Joints  

SciTech Connect

Because failures in lead-free solder joints occur at locations other than the most highly shear-strained regions, reliability prediction is challenging. To gain physical understanding of this phenomenon, physically based understanding of how elastic and plastic deformation anisotropy affect microstructural evolution during thermomechanical cycling is necessary. Upon solidification, SAC305 (Sn-3.0Ag-0.5Cu) solder joints are usually single or tricrystals. The evolution of microstructures and properties is characterized statistically using optical and orientation imaging microscopy. In situ synchrotron x-ray measurements during thermal cycling are used to examine how crystal orientation and thermal cycling history change strain history. Extensive characterization of a low-stress plastic ball grid array (PBGA) package design at different stages of cycling history is compared with preliminary experiments using higher-stress package designs. With time and thermal history, microstructural evolution occurs mostly from continuous recrystallization and particle coarsening that is unique to each joint, because of the specific interaction between local thermal and displacement boundary conditions and the strong anisotropic elastic, plastic, expansion, and diffusional properties of Sn crystals. The rate of development of recrystallized microstructures is a strong function of strain and aging. Cracks form at recrystallized (random) boundaries, and then percolate through recrystallized regions. Complications arising from electromigration and corrosion are also considered.

Bieler, Thomas R.; Zhou, Bite; Blair, Lauren; Zamiri, Amir; Darbandi, Payam; Pourboghrat, Farhang; Lee, Tae-Kyu; Liu, Kuo-Chuan (Michigan); (Cisco)

2013-04-08

354

Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential  

PubMed Central

The majority of B lymphocytes in the adult mouse are generated in the bone marrow from hematopoietic stem cells (HSCs) that first appear in the aorta-gonado-mesonephros region of the fetus on embryonic day (E) 10.5–11. Comparatively less is known about B-cell development during embryogenesis. For example, which specific embryonic tissues participate in B lymphopoiesis and whether hematopoietic differentiation is skewed toward specific B-cell subsets in the embryo are unanswered questions, because the systemic circulation is initiated early during embryogenesis, resulting in an admixture of cells potentially originating from multiple sites. We demonstrate, using Ncx1?/? mice that lack systemic blood circulation, that the E9 yolk sac (YS) and the intra-embryonic para-aortic splanchnopleura (P-Sp) tissues independently give rise to AA4.1+CD19+B220lo-neg B progenitor cells that preferentially differentiate into innate type B-1 and marginal zone (MZ) B cells but not into B-2 cells upon transplantation. We have further demonstrated that these B-1 progenitor cells arise directly from YS and P-Sp hemogenic endothelium. These results document the initial wave of innate B lymphopoietic progenitor cells available for seeding the fetal liver at E11. The results of these studies expand our knowledge of hemogenic endothelial sites specifying distinct B-1 and MZ cell fates apart from B-2 cells and independent of an HSC origin during development.

Yoshimoto, Momoko; Montecino-Rodriguez, Encarnacion; Ferkowicz, Michael J.; Porayette, Prashanth; Shelley, W. Christopher; Conway, Simon J.; Dorshkind, Kenneth; Yoder, Mervin C.

2011-01-01

355

Malignant transformation of metachronous bilateral Schneiderian inverted papilloma of the lacrimal sac: management considerations and the contentious issue of orbital exenteration.  

PubMed

The authors present an unusual case of malignant transformation of metachronous bilateral Schneiderian inverted papilloma (IP) of the lacrimal sac. Such pathology has been sparingly covered in prior published literature, in particular with little formal discussion surrounding its optimal management. We describe the clinical presentation, course and management in a 35-year-old male with histopathological diagnosis of Squamous cell carcinoma (SCC) arising within IP. He underwent radical surgery, including orbital exenteration and medial maxillectomy. Our patient re-presented with IP in the contralateral side and subsequent malignant transformation to SCC with disseminated disease. Unfortunately he succumbed to disease approximately 20 months following initial surgery. This case raises several important questions with regard to appropriate treatment. In particular, we discuss the various management options with special consideration given to the contentious topic of orbital exenteration in such patients. We emphasise two particular controversial issues, namely, oncological efficacy of orbital preservation and the functional compromise that may result in the preserved eye. PMID:23912602

Islam, Shofiq; Eisenberg, Robert L; Hoffman, Gary R

2014-07-01

356

Fluorometric analysis of endocytosis and lysosomal proteolysis in the rat visceral yolk sac during whole embryo culture.  

PubMed

Using spectrofluorimetry and fluorescence microscopy, we analyzed the uptake and degradation of fluorescein isothiocyanate-conjugated bovine serum albumin (FITC-albumin) by the rat visceral yolk sac (VYS) during whole embryo culture. Rat conceptuses exposed continuously to FITC-albumin had linear increases of both acid-soluble and acid-insoluble FITC fluorescence in the VYS. Smaller amounts of FITC fluorescence that were nearly all acid soluble accumulated in the extraembryonic fluid, while the embryo proper did not accumulate a significant amount of fluorescence. During a chase period following a pulse exposure to FITC albumin, FITC fluorescence in the VYS decreased linearly, while that in the extraembryonic fluid and culture medium increased. Addition of proteinase inhibitors to the culture medium together with FITC-albumin increased acid-insoluble FITC-fluorescence in the VYS tissue but decreased acid-soluble fluorescent degradation products in the yolk sac, extraembryonic fluid, and the culture medium. Fluorescence microscopy of yolk sacs exposed to FITC-albumin revealed that the fluorescence was localized in apical vacuoles of the yolk sac epithelium and decreased substantially during a chase period. In conceptuses exposed to proteinase inhibitors, the yolk sac epithelium had enlarged vacuoles containing FITC-fluorescence whose clearance in pulse-chase experiments was effectively blocked. Overall, these data suggest that FITC-albumin resembles 125l-albumin in its processing by the VYS and that the fluorescent protein is an attractive alternative tracer molecule for studies of the effects of embryotoxicants on yolk sac function during whole embryo culture. PMID:9358607

Ambroso, J L; Larsen, S V; Brabec, R K; Harris, C

1997-09-01

357

CA125-producing clear cell adenocarcinoma arising from the upper ureter and renal pelvis.  

PubMed

Clear cell adenocarcinomas similar to those found in the female genital organs can arise in the lower urinary tract of both women and men. Clear cell adenocarcinomas occurring in the upper urinary system are exceedingly rare. Here, we present a case of clear cell adenocarcinoma arising from the upper ureter and renal pelvis of a postmenopausal woman with a ureteral stone. The patient had elevated serum levels of cancer antigen (CA) 125 (103.80 U/mL) and CA19-9 (151.96 U/mL). The tumor showed typical features of tubulopapillary structures lined with clear-to-eosinophilic cytoplasm and frequent hobnail configuration. The tumor cells were immunoreactive for cytokeratin 7, cytokeratin 20, carcinoembryonic antigen and CA125, but negative for PAX-2 and alpha-methylacyl coenzyme A racemase. Given the presence of intestinal and squamous metaplasia of the adjacent urothelium, we propose that this clear cell adenocarcinoma developed through a metaplastic process. The tumor behaved so aggressively that the patient developed multiple metastases and died of the disease 5 months after radical nephroureterectomy. PMID:20103490

Shih, Chi-Min; Huang, Chuan-Te; Chi, Ching-Huang; Lin, Jui-Wei; Pan, Chin-Chen

2010-01-01

358

Adenocarcinoma arising from an anal gland--Report of a case  

PubMed Central

INTRODUCTION Adenocarcinoma arising from an anal gland is extremely rare. Most anal canal cancers are squamous cell carcinoma, and adenocarcinoma is infrequently diagnosed. Diagnostic criteria and the standard treatment for adenocarcinoma of the anal canal have not been clearly defined, in part because of the rarity of this lesion. PRESENTATION OF CASE An 84-year-old man who presented with a piece of tissue prolapsing from the anus. An incisional biopsy showed adenocarcinoma, and an abdomino-perineal resection was then performed. Cytokeratin 7 (CK7), cytokeratin 19 (CK19) stained positive in the specimen, suggesting that the tumor developed from an anal gland. The patient was discharged after surgery without any complications. DISCUSSION Exact diagnostic criteria for adenocarcinoma of the anal canal have not been previously described. In the present case, CK7 and CK19 were stained, and the tumor showed positivity for both of these markers, which is compatible with the staining patterns of anal gland origin cancer. Radical resection is recommended rather than local resection, because of the tumor's high recurrence rate. Some authors recommend combined modality treatment with preoperative or postoperative chemoradiotherapy because of the high rate of distant recurrence. CONCLUSION The preoperative diagnosis of adenocarcinoma arising from an anal gland is not easily established. However, it may be possible to suspect an anal glandular adenocarcinoma based on a meticulous physical examination, appropriate diagnostic studies and pathological findings on biopsy.

Sakamoto, Takashi; Konishi, Fumio; Yoshida, Takayoshi; Yoshinaga, Yasuo; Izumo, Toshiyuki; Lefor, Alan

2014-01-01

359

Serous carcinoma arising in endometrial polyps: clinicopathologic study of 4 cases.  

PubMed

Uterine serous carcinoma (USC) is a rare variant of endometrial cancer that is not related to increased estrogen level; rather, it arises in a background of atrophic endometrium. Our aim was to describe clinicopathologic features of 4 cases of USC arising in endometrial polyps (EPs). The mean age of the patients at presentation was 53 years (range, 50-61 years). All patients presented with postmenopausal bleeding. In 3 patients, endometrial curretings were done before surgery, which was reported as EP with superficial foci of USC, EP with few clusters of atypical cells, and high-grade serous carcinoma, respectively. All patients underwent hysterectomy with bilateral salpingo-oophorectomy and omental sampling. The uterine cavity showed an EP in all cases ranging in size from 2 to 3.5 cm (mean, 3 cm). The hysterectomy specimens revealed USC in EP as well as the adjacent endometrium in 3 patients. The nonneoplastic endometrium was atrophic in all cases. Residual tumor was not found in the endometrium in 1 case. Omental metastatic deposits were found in all cases. Tumor deposits were also seen in the serosa of uterus, fallopian tubes, and parametrium in 1 case. Two patients died of disease 2 years after diagnosis. The remaining 2 patients are alive after a follow-up of 3 years, respectively. In conclusion, USC is a rare aggressive tumor, and to establish the diagnosis, it is important to look for the small foci of the tumor in the atrophic endometrium and on the surface of the polyps as these patients are likely to harbor additional disease in the uterus or extrauterine sites. The postmenopausal group is at high risk for developing these tumors; therefore, all the endometrial biopsies/curettings and the EPs in this age group should be thoroughly sampled. PMID:23276456

Idrees, Romana; Din, Nasir Ud; Fatima, Saira; Kayani, Naila

2013-06-01

360

Papillary Serous Carcinoma Arising from Adenomyosis Presenting as Intramural Leiomyoma  

Microsoft Academic Search

Adenocarcinoma arising from adenomyosis uteri is rare. Herein, we reported a patient with papillary serous carcinoma arising from adenomyosis. The patient was a 61-year-old woman who received tamoxifen for treatment of her breast cancer over the past five years. In hysterectomy specimen taken for investigating her uncontrolled bleeding with suspicion of uterine myoma, multiple adenomyotic foci were found in the

Narges Izadi-Mood; Nasrin Samadi; Soheila Sarmadi; Zahra Eftekhar

361

CT features, mimics and atypical presentations of gastrointestinal stromal tumor (GIST)  

PubMed Central

The term stromal tumor was coined in 1983 by Clark and Mazur for smooth muscle neoplasm of the gastrointestinal tract (GIT). Gastrointestinal stromal tumors (GIST) are nonepithelial tumors arising from the interstitial cells of Cajal, which express KIT protein-CD117 on immunohistochemistry. GIST can arise anywhere in the GIT, including the mesentery, omentum, and retroperitoneum.

Sripathi, Smiti; Rajagopal, KV; Srivastava, Rajendra Kumar; Ayachit, Anurag

2011-01-01

362

Primary sex cord-like variant of endometrioid adenocarcinoma arising from endometriosis.  

PubMed

Endometriosis, a relatively common disease generally affecting women in the reproductive age group, is mostly found in the pelvic organs. Although endometriosis is a benign disease, some malignant tumors have been reported to develop in endometriotic lesions, most commonly in the ovary. The relationship between endometriosis and malignancy is not well known, but the majority of endometriosis-associated ovarian malignancies are usually endometrioid adenocarcinomas and clear cell carcinomas. The sex cord-like variant of endometrioid adenocarcinoma is a rare tumor that histologically closely resembles the sex cord-stromal tumor. Despite its rarity, the correct histological diagnosis of the sex cord-like variant of endometrioid adenocarcinoma is crucial to avoid misdiagnosis of a less aggressive tumor. We here report a 53-year-old woman who was diagnosed as having this very rare subtype of endometroid adenocarcinoma curiously arising from an endometriotic lesion at the site of previous salpingo-oophorectomy. The tumor was diagnosed based on light microscopy and immunohistochemistry. PMID:19024607

Kauppila, Saila; Altinörs, Mehmet; Väre, Päivi; Liakka, Annikki; Knuuti, Eila; Nissi, Ritva

2008-09-01

363

Analysis of interdigital spaces during mouse limb development at intervals following amniotic sac puncture  

PubMed Central

A spectrum of limb abnormalities ranging from adactyly, syndactyly, acrosyndactyly to nail hypoplasia was encountered in mouse embryos subjected to amniotic sac puncture at the corresponding gestational stage when human chorionic villus sampling (cvs) would normally be performed clinically. Previous skeletal studies revealed that, apart from the occasional incidence of fusion of 2 distal phalanges, syndactyly usually only affected the soft tissues within the interdigital spaces. A similar situation was also observed in cases of adactyly; while the skeletal elements of the digits were present, the soft tissues in the interdigital spaces failed to separate. A transient period of bradycardia is induced, possibly secondary to compression of the embryo by the extraembryonic membranes and uterine muscles following amniotic sac puncture. These factors, we believe, produce temporary hypoxia/ischaemia of the distal extremities, and may lead to the modification of the interdigital mesenchymal tissues within the autopods. In order to investigate the mechanism(s) underlying soft tissue syndactyly, limbs recovered at 0.5, 4, 8, 12, 24, or 36 h following amniotic sac puncture (ASP) were examined histologically. Vascular disruption in the form of localised areas of haemorrhage, vascular dilatation and congestion and the presence of fluid-filled cavities occurred in relation to the marginal vein and vascular plexus in the interdigital spaces. It is hypothesised that this interfered with the normal equilibrium of the preset programs of mitosis/cell death and apoptosis within the mesenchymal cells of the interdigital spaces. Apoptosis in these areas was inhibited in the majority of the experimental limbs analysed 4 h after ASP. Instead of undergoing necrosis/apoptosis, increased mitotic activity was usually observed from 8 h following ASP at the sites where apoptosis would normally be expected to be seen. The aberrant fate of the interdigital mesenchyme following ASP and the underlying mechanism(s) involved are discussed, as is the critical importance of an adequate vascular supply to the interdigital spaces during the morphogenesis of the autopod. We believe that this report contributes to understanding the mechanism(s) which lead to syndactyly following ASP, and the limb defects occasionally seen following cvs when this is undertaken during early gestation.

CHANG, H.-H.; TSE, Y.; KAUFMAN, M. H.

1998-01-01

364

Synthetic, spectroscopic and X-ray crystallographic structural study of the monomeric [Cu(pysme)(sac)(MeOH)] and dimeric [Cu(6mptsc)(sac)] 2 complexes [pysme=anion of the pyridine-2-carboxaldehyde Schiff base of S-methyldithiocarbazate, 6mptsc=the anion of the 6-methyl-2-pyridinecarbaldehydethiosemicarbazone and sac=the saccharinate anion  

Microsoft Academic Search

New mixed-ligand copper(II) complexes of empirical formulas [Cu(pysme)(sac) (CH3OH)] and [Cu(6mptsc)(sac)]2 have been synthesized and characterized by conductance, magnetic, IR and electronic spectroscopic techniques. X-ray crystallographic structure analyses of these complexes indicate that in both complexes the copper(II) ions adopt a five-coordinate distorted square-pyramidal geometry with an N3SO donor environment. The Schiff bases are coordinated to the copper(II) ions as

Mohammad Akbar Ali; A. H Mirza; Thahira B. S. A Ravoof; Paul V Bernhardt

2004-01-01

365

Symptomatic Hibernoma: A Rare Soft Tissue Tumor  

PubMed Central

Hibernomas are benign soft tissue tumors containing prominent brown adipocytes that resemble normal brown fat. Hibernomas have not been associated with malignant potential; however, they are similar in clinical presentation to malignant tumors like liposarcomas. This article describes the clinical, radiographic, and histologic features of a patient with a hibernoma arising from the left superior flank.

Lim, Robert B; Lin-Hurtubise, Kevin; Johnson, Eric A

2012-01-01

366

Localised radiotherapy for a ferret with possible anal sac apocrine adenocarcinoma.  

PubMed

A seven-year-old, neutered male ferret was referred to our hospital with two perianal masses (2.4x3.0 and 2.4x3.5 cm, respectively) that had recurred after initial surgical excision. Complete resection of the masses was impossible as there was deep invasion along the rectum. On histopathology, the masses were diagnosed as apocrine adenocarcinoma possibly of anal gland origin based on tumour location. There was marked response to localised radiotherapy using an orthovoltage unit at 4 Gy, twice weekly. No visible mass was detectable after six doses of radiation. However, at that time, pleural effusion was diagnosed and radiotherapy was discontinued. Cytology of a sample of the pleural effusion suggested mesothelioma, and no obvious pulmonary metastasis of anal sac adenocarcinoma were identified on thoracic radiography. The ferret died at home on day 71 after the first admission. PMID:18631226

Nakata, M; Miwa, Y; Nakayama, H; Sakai, T; Sasaki, N

2008-09-01

367

Air sac fluke Circumvitellatrema momota in a captive blue-crowned motmot (Momotus momota) in France.  

PubMed

Postmortem examination of a 4-mo-old captive-born blue-crowned motmot (Momotus momota) at the Montpellier Zoo in France revealed the presence of air sac flukes. Circumvitellatrema momota (Digenea: Cyclocoelidae) was suspected and confirmed by molecular genetic analysis. Digenean metacercariae were extracted from an invasive species of terrestrial snail, the conical periwinkle, Subulina striatella. Molecular genetic analysis determined that these metacercariae were also C. momota, confirming that all the stages of this parasite's life cycle were present and that birds were likely becoming infected by eating these infected snails. It is likely that this trematode was imported into the greenhouse with a wild-caught motmot. The conical periwinkle snail appears to have been imported into the zoo with the plants in 2007 when the greenhouse was built. Treatments, which have been disappointing, are discussed, as well as preventive measures to avoid dissemination of the parasite into other bird collections in Europe. PMID:23082545

Libert, Cédric; Jouet, Damien; Ferté, Hubert; Lemberger, Karin; Keck, Nicolas

2012-09-01

368

Melanoma arising on a scar 10 years after a burn: management and review of the literature.  

PubMed

We report a case of a melanoma arising after about 10 years after a burn injury. This is an uncommon example of a carcinogenetic event that could be prevented or diagnosed early. Usually, the mutagenic event clinically appears many years after the burn especially if it was not treated correctly with a careful surgical approach. The average time of latency could be found in literature as 46.5 years from the burn, whereas our case was only 10. A frequent and very long follow-up of the burn scars could represent a valid prophylactic option to avoid neoplastic proliferation if the tumor appears. PMID:22627497

Ribero, Simone; Grassi, Marcella; Caliendo, Virginia; Lauro, Danilo; Macripò, Giuseppe

2012-07-01

369

First trimester three-dimensional ultrasound volumetry of the gestational sac.  

PubMed

First trimester amniotic fluid is an ultrafiltrate of maternal plasma and constitutes the major component of gestational sac volume (GSV). We hypothesized that GSV, assessed by 3-dimensional (3-D) ultrasound volumetry, would reflect function of the early uteroplacental unit and therefore provide a basis for predicting pregnancy outcome. We tested this hypothesis in 38 pregnancies which had first trimester GSV measurements by two investigators thus allowing determination of interobserver variation. Gestational age (GA) was based on a careful history and conventional 2-dimensional ultrasound measurements. Serum for beta-hCG, estradiol (E2) and progesterone (P) was obtained at the time of ultrasound examinations. "Normal" outcome was defined as confirmation of a viable fetus. "Abnormal outcome" was defined as either a "blighted ovum" or embryonic demise. Statistical analysis was performed by Independent t-test and regression analysis. There were 31 "normal" and 7 "abnormal" pregnancies studied between 5 and 11 weeks gestation (mean +/- SD 8.3 +/- 1.3 weeks). GSV was significantly correlated to GA (r = 0.74, P < 0.001), higher than to beta-hCG (r = 0.40, P = 0.034), E2 (r = 0.70, P < 0.001) and P (r = 0.21, P = 0.334), respectively. In the abnormal group 2/2 pregnancies with a twin sac had a GSV within 1 SD of the mean. 3/5 cases of missed abortions or blighted ovum had a GSV < 2 SD of the mean. The interobserver correlation was high (r = 0.99, P < 0.00f2p4This is the first clinical study investigating the diagnostic use of 3-D ultrasound volumetry in first trimester pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7695361

Steiner, H; Gregg, A R; Bogner, G; Graf, A H; Weiner, C P; Staudach, A

1994-01-01

370

Sac-D Aquarius a Satellite for Ocean, Climate and Environment. One Year of Data  

NASA Astrophysics Data System (ADS)

The SAC-D/Aquarius satellite was launched in June 10, 2011. It's a joint mission between Argentina (through CONAE) and US (NASA). This satellite is a true Observatory with a suite of sensors for Earth Observation, its weight is 1400 kg, sun-synchronous orbit at 657 km (6 pm ascendant node), revisit of seven days. Other space agencies have contributed with instruments and support (facilities and ground segment), as CNES, CSI, ASI and AEB/INPE. The primary objective is to monitor global variations in ocean surface salinity (SSS) in order to improve the knowledge about ocean circulation, water cycle and climate. The SSS is performed with Aquarius instrument (NASA). Other oceanic and atmospheric parameters are measured with a MWR, from CONAE, in K and Ka band, as wind speed, rain rate, sea ice, water vapour and liquid water in clouds. The thermal camera (NIRST) estimates sea surface temperature and detect high temperature events (fires and volcanic eruptions). The High Sensitivity Camera (HSC) generates night images (very useful for fishery activity monitoring in the sea, studying of electrical storms, polar auroras and urban application). The DCS (Data Collection System, from CONAE) can receive meteorological and environmental data from ground platforms and distribute among users. The TDP (Technological Demonstration Package, from CONAE) measures different parameters of satellite position and velocity. Other two important instruments are ROSA (from Italy) and CARMEN 1 (from France). The first is an atmospheric sounder, it allows elaborating atmospheric profiles of temperature, pressure and humidity, and the second has detectors for studies of space debris and the effects of radiation on electronic devices. This work provides a review of the first year of data, including the status of calibration and validation, other finding and at the same time we want to present the progress in the active educational and outreach program including the information of SAC-D Aquarius Mission.

Torrusio, S.; Lagerloef, G.; Rabolli, M.; LeVine, D.

2012-07-01

371

The Fate of 'Thorotrast' (Thorium Dioxide) injected into the Dorsal Lymph Sac of the Frog, Rana temporaria  

Microsoft Academic Search

SUMMARY Thorotrast (a colloidal suspension of thorium dioxide) injected into the dorsal lymph sac of the common frog, Rana temporaria, can be shown by radiological methods to pass through the anterior lymph hearts and so into the blood system. From the blood the thorotrast is removed, as in mammals, by cells of the reticulo-endothelial system and by macrophages, the sites

G. E. H. FOXON; K. E. K. ROWSON

1956-01-01

372

Identification of genes potentially related to biomineralization and immunity by transcriptome analysis of pearl sac in pearl oyster Pinctada martensii.  

PubMed

Pearl oyster Pinctada martensii is cultured for production of pearl in China. It needs to implant a mantle graft cut from a donor oyster and a seed nucleus into the gonad of the host oyster to produce a pearl. Pearl sac surrounding the nucleus is formed by the proliferation of the implanted mantle graft from the outer mantle epithelial cells in the host oyster. The pearl sac is responsible for production of a cultured pearl. A comprehensive transcriptome analysis on pearl sac will help to understand the mechanism on pearl formation and immune response of host oyster after nucleus implantation. In the present study, 39,400,004 reads were produced from the pearl sac using RNA-sequence technology and then assembled into 102,762 unigenes. More than 22.4% of these unigenes were possibly involved in approximately 219 known signaling pathways. A total of 37,188 unigenes were annotated based on sequences similarities with known proteins. Fifty-one biomineralization-related unigenes and 268 immune-related unigenes were not previously detected in P. martensii. The un-annotated unigenes may be some genes specifically existed in P. martensii. These annotated or un-annotated unigenes in the present studies were valuable for the future investigation on molecular mechanism of pearl formation and immune response of the species. PMID:22351046

Zhao, Xiaoxia; Wang, Qingheng; Jiao, Yu; Huang, Ronglian; Deng, Yuewen; Wang, Huan; Du, Xiaodong

2012-12-01

373

Thermal stress and physiological reaction of broiler chickens after injection of linseed oil into the yolk sac  

Microsoft Academic Search

The aim of the study was to determine the effect of injecting linseed oil into the yolk sac of chicks on the physiological reaction of birds exposed to elevated air temperature. Day-old chicks were assigned to 4 groups: 1 - chickens reared under standard thermal conditions; 2 - on the first day of rearing, 0.25 ml of linseed oil was

E. SOSNÓWKA-CZAJKA; I. SKOMORUCHA; E. HERBUT

374

Ultrafast Forwarding Architecture Using a Single Optical Processor for Multiple SAC-Label Recognition Based on FWM  

Microsoft Academic Search

We propose and demonstrate a novel ultrafast label processor that can recognize multiple spectral amplitude coded (SAC) labels using four wave mixing (FWM) sideband allocation and selective optical filtering. Our proposed solution favors hardware simplicity over bandwidth efficiency in order to achieve ultra- fast label recognition at reasonable cost. Our implementation, unlike all other optical label processing techniques, does not

JosÉ Bernardo Rosas-FernÁndez; Simon Ayotte; Leslie A. Rusch; Sophie LaRochelle

2008-01-01

375

Molecular dynamics simulations of the hyperthermophilic protein sac7d from Sulfolobus acidocaldarius: contribution of salt bridges to thermostability1  

Microsoft Academic Search

Hyperthermophilic proteins often possess an increased number of surface salt bridges compared with their mesophilic homologues. However, salt bridges are generally thought to be of minor importance in protein stability at room temperature. In an effort to understand why this may no longer be true at elevated temperatures, we performed molecular dynamics simulations of the hyperthermophilic protein Sac7d at 300

Paul I. W. de Bakker; Philippe H. Hunenberger; J. Andrew McCammon

1999-01-01

376

Incorporation of strontium into the calcium carbonate crystals of the endolymphatic sac in the tree frog (Hyla arborea japonica).  

PubMed

Tree frogs were loaded with strontium chloride (SrCl2). The incorporation of strontium metal into the calcium carbonate (CaCO3) crystals located both in the inner ear and in the endolymphatic sac was studied by x-ray microanalysis (XMA) and scanning electron microscopy (SEM). In the inner ear, strontium was not recognized except for traces in a few crystals. When observed by SEM, these crystals had a faceted body and two pointed ends with rather smooth surfaces. However, in the endolymphatic sac, which greatly expands into the spinal canal, strontium was clearly present at every surface of all crystals. Careful examinations by point and line XMA revealed that strontium x-ray counts were highest at the pointed ends and decreased sharply and then gradually toward the equator of the crystals. SEM observations revealed that the crystals in the endolymphatic sac always had rough and irregular surfaces regardless of their shapes and sizes. Calcium was always found in crystals of both organs. Except for calcium and strontium, other elements including sodium and heavier elements were negligible in XMA. These findings suggest that strontium is incorporated into the crystals only in the endolymphatic sac, and the rough-surfaced covering of these crystals reflects newly deposited strontium salt. It seems to indicate that these crystals grow predominantly by accretion. PMID:3619090

Kawamata, S

1987-06-01

377

Fate of the excluded abdominal aortic aneurysm sac: Long-term follow-up of 831 patients  

Microsoft Academic Search

Purpose: Nonresective treatment of the infrarenal abdominal aortic aneurysm by proximal and distal ligation of the aneurysm sac (exclusion) combined with aortic bypass has been previously reported. A 10-year experience with 831 patients undergoing this procedure was reviewed.Methods: From 1984 to 1994, 831 (761 elective, 70 urgent) of 1103 patients being treated for abdominal aortic aneurysm underwent repair with the

Michael Resnikoff; R. Clement Darling; Benjamin B. Chang; William E. Lloyd; Philip S. K. Paty; Robert P. Leather; Dhiraj M. Shah

1996-01-01

378

A novel genomic disorder: a deletion of the SACS gene leading to spastic ataxia of Charlevoix-Saguenay.  

PubMed

We report a Belgian patient with early-onset cerebellar ataxia, progressive spasticity, learning difficulties and moderate perceptive hearing loss. Array-Comparative Genomic Hybridisation (aCGH) detected a 1.54 Mb deletion on chromosome 13q12.12. This microdeletion occurred de novo and encompasses the SACS gene. Mutations in SACS are known to cause a recessive condition, similar to the patient's phenotype, called autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). Sequencing of the remaining SACS allele revealed a hemizygous mutation c.10517T>C in exon 9, resulting in an amino-acid substitution (p.F3506S). This is the first patient with ARSACS that carries a de novo chromosomal deletion comprising SACS. We demonstrate the presence of homologous segmental duplications at the breakpoint-containing regions. This suggests non-allelic homologous recombination as the mechanism generating this deletion and explains the previous description of copy number variations of this region. This finding confirms the contribution of aCGH to gene identification in autosomal recessive disorders. PMID:18398442

Breckpot, Jeroen; Takiyama, Yoshihisa; Thienpont, Bernard; Van Vooren, Steven; Vermeesch, Joris Robert; Ortibus, Els; Devriendt, Koenraad

2008-09-01

379

Twin oil sacs facilitate the evolution of a novel type of pollination unit (meranthium) in a South African orchid.  

PubMed

The unique floral morphology of the South African orchid H. pulchra, with its twin meranthia, is best explained as an adaptation to pollination by oil-collecting bees. Flowers consisting of meranthia (floral parts that function as single pollination units; commonly observed in garden Iris) are extremely rare among the angiosperms and their significance poorly understood. Unlike all other known examples of meranthia, the novel type described for H. pulchra is not bilabiate. All Huttonaea species are unique in having twin petal sacs with glandular verrucae that secrete oil and are pollinated by Rediviva (Melittidae) oil-collecting bees. But only Huttonaea pulchra has long and widely divergent petal claws that place the oil sacs well beyond the reach of a centrally positioned bee. The wide separation of these sacs forces the pollinator, R. colorata, to visit each side of the flower independently and effectively divides the flower into two meranthia. Molecular data indicate that the evolution of the Huttonaea-type meranthium was dependent on the prior evolution of the oil flower/oil bee relationship. Meranthium evolution was also facilitated by the presence of oil in two separate structures (petal sacs) that were not physically constrained to remain in close proximity. PMID:21622392

Steiner, Kim E

2010-02-01

380

Hydrolysis of an exogenous 125I-labelled protein by rat yolk sacs. Evidence for intracellular degradation within lysosomes.  

PubMed Central

When added to the serum-free medium in which 17.5-day rat yolk sacs were incubated, formaldehyde-denatured 125I-labelled bovine serum albumin was rapidly degraded. More than 80% of the radiolabelled digestion products appearing in the incubation medium consisted of [125I]iodo-L-tyrosine; larger digestion products were found only in association with the yolk-sac tissue. In the early stages of an incubation, low-molecular-weight digestion products began to appear in the incubation medium only after they could be detected within the tissue, and progressive association of trichloroacetic acid-insoluble radioactivity with the tissue preceded both these events. None of the observed proteolysis could be attributed to proteinases released into the incubation medium. Tissue-associated acid-insoluble radioactivity showed a lysosomal distribution on sub-cellular fractionation, and cell-free homogenates of yolk sacs degraded albumin only at acid pH values. Progressively decreasing the rat of pinosome formation (either by progressively lowering the incubation temperature or by the use of increasing concentrations of the metabolic inhibitor rotenone) caused a corresponding decrease in the rate of degradation of albumin. These findings indicate that, in vitro, formaldehyde-denatured 125I-labelled bovine serum albumin is digested by rat yolk sacs exclusively intracellularly, within lysosomes.

Livesey, G; Williams, K E

1979-01-01

381

A case of primary retroperitoneal mucinous cystadenoma arising from the retropancreatic area.  

PubMed

Primary retroperitoneal mucinous cystadenoma is an extremely uncommon tumor, even though mucinous cystadenoma often develops in the ovary and less frequently in the pancreas. A 21-year-old female was admitted to our hospital due to severe abdominal pain. A well-demarcated, oval shaped cystic tumor at the retropancreatic area with displacement of the pancreas and surrounding major vessels was observed on CT and MRI. Exploratory laparotomy was performed, and complete excision of the entire cyst was performed without complication. The pathologic finding was consistent with primary retropancreatic mucinous cystadenoma. To the best of our knowledge, this report is the first to describe a case of retropancreatic mucinous cystadenoma arising from the retropancreatic area in Korea. PMID:24651593

Nam, Yoon Jeong; Kim, Tae Nyeun; Kim, Kook Hyun; Gu, Min Geun; Lee, Jae Young

2014-03-25

382

A Demonstration of the System Assessment Capability (SAC) Rev. 1 Software for the Hanford Remediation Assessment Project  

SciTech Connect

The System Assessment Capability (SAC) is a suite of interrelated computer codes that provides the capability to conduct large-scale environmental assessments on the Hanford Site. Developed by Pacific Northwest National Laboratory for the Department of Energy, SAC models the fate and transport of radioactive and chemical contaminants, starting with the inventory of those contaminants in waste sites, simulating transport through the environment, and continuing on through impacts to the environment and humans. Separate modules in the SAC address inventory, release from waste forms, water flow and mass transport in the vadose zone, water flow and mass transport in the groundwater, water flow and mass transport in the Columbia River, air transport, and human and ecological impacts. The SAC supports deterministic analyses as well as stochastic analyses using a Monte Carlo approach, enabling SAC users to examine the effect of uncertainties in a number of key parameters. The initial assessment performed with the SAC software identified a number of areas where both the software and the analysis approach could be improved. Since that time the following six major software upgrades have been made: (1) An air pathway model was added to support all-pathway analyses. (2) Models for releases from glass waste forms, buried graphite reactor cores, and buried naval reactor compartments were added. (3) An air-water dual-phase model was added to more accurately track the movement of volatile contaminants in the vadose zone. (4) The ability to run analyses was extended from 1,000 years to 10,000 years or longer after site closure. (5) The vadose zone flow and transport model was upgraded to support two-dimensional or three-dimensional analyses. (6) The ecological model and human risk models were upgraded so the concentrations of contaminants in food products consumed by humans are produced by the ecological model. This report documents the functions in the SAC software and provides a number of example applications for Hanford problems. References to theory documents and user guides are provided as well as links to a number of published data sets that support running analyses of interest to Hanford cleanup efforts.

Eslinger, Paul W.; Kincaid, Charles T.; Nichols, William E.; Wurstner, Signe K.

2006-11-06

383

Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment.  

PubMed

A lot of effort has been done to study how cancer cells react to low-oxygen tension, a condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor are incapable to restore oxygenation, therefore perpetuating hypoxia, which, in turn, will fuel tumor progression, metastasis and resistance to antitumor therapies. Nevertheless, how stromal components including blood and lymphatic endothelial cells, pericytes and fibroblasts, as well as hematopoietic cells, respond to low-oxygen tension in comparison with their normoxic counterparts has been a matter of investigation in the last few years only and, to date, this field of research remains poorly understood. In general, opposing phenotypes can arise from the same stromal component when embedded in different tumor microenvironments, and, vice versa, different stromal components can have opposite reaction to the same tumor microenvironment. In this article, we will discuss the emerging link between tumor stroma and hypoxia, and how this complexity is translated at the molecular level. PMID:23604130

Casazza, A; Di Conza, G; Wenes, M; Finisguerra, V; Deschoemaeker, S; Mazzone, M

2014-04-01

384

Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues.  

PubMed

Depletion of spindle assembly checkpoint (SAC) genes in Drosophila epithelial tissues leads to JNK-dependent programmed cell death and additional blockade of the apoptotic program drives tumorigenesis. A recent report proposes that chromosomal instability (CIN) is not the driving force in the tumorigenic response of the SAC-deficient tissue, and that checkpoint proteins exert a SAC-independent tumor suppressor role. This notion is based on observations that the depletion of CENP-E levels or prevention of Bub3 from binding to the kinetochore in Drosophila tissues unable to activate the apoptotic program induces CIN but does not cause hyperproliferation. Here we re-examined this proposal. In contrast to the previous report, we observed that depletion of CENP-E or Nsl1-the latter mediating kinetochore targeting of Bub3-in epithelial tissues unable to activate the apoptotic program induces significant levels of aneuploidy and drives tumor-like growth. The induction of the JNK transcriptional targets Wingless, a mitogenic molecule, and MMP1, a matrix metaloproteinase 1 involved in basement membrane degradation was also observed in these tumors. An identical response of the tissue was previously detected upon depletion of several SAC genes or genes involved in spindle assembly, chromatin condensation, and cytokinesis, all of which have been described to cause CIN. All together, these results reinforce the role of CIN in driving tumorigenesis in Drosophila epithelial tissues and question the proposed SAC-independent roles of checkpoint proteins in suppressing tumorigenesis. Differences in aneuploidy rates might explain the discrepancy between the previous report and our results. PMID:24626182

Clemente-Ruiz, Marta; Muzzopappa, Mariana; Milán, Marco

2014-05-01

385

Exponential stability of linear equations arising in adaptive identification  

Microsoft Academic Search

The stability, properties are examined of various time-varying linear differential equations which arise in model reference adaptive identification schemes. Necessary and sufficient conditions for exponential stability are presented.

B. Anderson

1977-01-01

386

On Some Brauer Subgroups Arising From Twists of Matrix Algebras  

Microsoft Academic Search

We study some relations between groups of continuous characters and subgroups of Brauer groups. Explicit determination of some subgroups of Brauer groups arising from this connection are done for some cases in the local fields via local class field theory.

Wen-Chen Chi; Hung-Min Liao; Ki-Seng Tan

2008-01-01

387

Localised fibrous mesothelioma arising in an intralobar pulmonary sequestration  

Microsoft Academic Search

A localised fibrous mesothelioma arising from an intralobar lung sequestration occurred in a 64 year old Turkish woman. This appears to be the first report of a mesothelioma occurring within a pulmonary sequestration.

N Paksoy; A Demircan; M Altiner; M Artvinli

1992-01-01

388

Localised fibrous mesothelioma arising in an intralobar pulmonary sequestration.  

PubMed

A localised fibrous mesothelioma arising from an intralobar lung sequestration occurred in a 64 year old Turkish woman. This appears to be the first report of a mesothelioma occurring within a pulmonary sequestration. PMID:1481189

Paksoy, N; Demircan, A; Altiner, M; Artvinli, M

1992-10-01

389

Acoustic Emission Arising from Plastic Deformation and Fracture.  

National Technical Information Service (NTIS)

This paper reviews current status of acoustic emission signal detection methods, theoretical analysis of acoustic emission sources and acoustic emission behavior of materials arising from plastic deformation and fracture. Recent developments in quantitati...

K. Ono

1980-01-01

390

Reproducible growth in tissue culture of retinoblastoma tumor specimens  

Microsoft Academic Search

Retinoblastoma is a unique embryonic tumor which fre quently arises because of an autosomal dominantly inherited mutation. Study of the genetic changes associated with reti- noblastomas requires techniques that allow proliferation of fresh tumor specimens in tissue culture. However, until the present study, there were no reported methods for routinely obtaining in vitro growth of fresh retinoblastoma tumor cells. When

B L Gallie; Wendy Holmes; Robert A. Phillips

1982-01-01

391

Chemotherapy trials in recurrent primary intracranial germ cell tumors  

Microsoft Academic Search

Gonadal germ cell tumors respond favorably to chemotherapy either at diagnosis or when they recur. Histologically similar tumors may arise in the CNS usually in the pineal or suprasellar regions. Although radiation therapy may produce a 5 year disease-free survival in excess of 60% in localized pure germinoma, gern cell tumors of other histology tend to recur. We have conducted

Jeffrey C. Allen; Georges Bosl; Russell Walker

1985-01-01

392

Large synovial osteochondromatosis arising from the interphalangeal joint of the thumb: a case report and review of the literature.  

PubMed

A 38-year-old woman presented with a very large synovial chondromatosis arising from the interphalangeal joint of the thumb. The tumor surrounded the interphalangeal joint and its size was approximately 3 cm. The range of motion was almost fused. Plain radiographs showed an extra-osseous tumor shadow with calcifications. The patient had no local recurrence at one year of follow-up after marginal resection of the tumor and synovectomy. Because this case showed no osteoarthritic changes, it can be classified as primary synovial chondromatosis with a tumor-like nature. Based on the clinical course and pathological report, our synovial chondromatosis case can be classified as Milgram stage 3. Our case report is unique in three respects: i) origin from the interphalangeal joint of the thumb, ii) a single lump of mass and iii) extremely large size. To our knowledge, a similar type of synovial chondromatosis has not been previously reported in the English literature. PMID:24511055

Muramatsu, Keiichi; Hashimoto, Takahiro; Tominaga, Yasuhiro; Taguchi, Toshihiko

2014-02-01

393

[Cerebral tumors and neoangiogenesis ].  

PubMed

Angiogenesis, which is the development of new vessels arising from the preestablished arborization, plays a fundamental role in tumor growth. Angiogenesis is the combination of antagonistic factors: proangiogenesis and antiangiogenesis factors. On the basis of the concept of relationship between angiogenesis and tumor growth, a promising new way of research is developing with the aim to control angiogenesis with an antitumor goal. The results of the preclinical trials point out the potential of antiangiogenesis agents in the fight against cancer. So, it was showed that tumor growth in animal models of syngenic or human tumors is inhibited by inhibitors of proangiogenic factors (like VEGF or FGF antibody ...) or by antiangiogenic factors. Endostatin, which is a natural inhibitor of angiogenesis, seems to be the most powerful molecule, able to achieve total and final regression of preestablished tumors. However, there are only preliminary data. Clinical trials are on the way. They should bring some answers concerning the place of these antiangiogenesis agents in the traditional therapeutic strategy. In neurooncology, just like in general cancerology, clinical trials have began with different molecules like Marismastat or Thalidomid. A review of the principal actors, preclinical and clinical trials in progress is presented. PMID:10599057

Jouanneau, E; Bachelot, T

1999-11-01

394

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem.  

PubMed

Medulloblastoma is a malignant brain tumor of childhood that comprises at least four molecularly distinct subgroups. We have previously described that cerebellar granule neuron precursors may give rise to the subgroup with a molecular fingerprint of Sonic hedgehog (Shh) signaling. Other recent data indicate that precursor cells within the dorsal brain stem may serve as cellular origins for Wnt-associated medulloblastomas. To see whether Shh-associated medulloblastomas are also able to develop in the dorsal brainstem, we analyzed two lines of transgenic mice with constitutive Shh signaling in hGFAP- and Math1-positive brainstem precursor populations, respectively. Our results show that in both of these lines, medulloblastomas arise from granule neuron precursors of the cochlear nuclei, a derivative of the auditory lower rhombic lip. This region is distinct from derivatives of precerebellar lower rhombic lip where medulloblastomas arise in mice with constitutive-active Wnt signaling. With respect to their histology and the expression of appropriate markers, Shh tumors from the murine cochlear nuclei perfectly resemble human Shh-associated medulloblastomas. Moreover, we find that in a series of 63 human desmoplastic medulloblastomas, 21 (33%) have a very close contact to the cochlear nuclei on MR imaging. In conclusion, we demonstrate that precursors of the murine rhombic lip, which either develop into cerebellar or into cochlear granule neurons, may give rise to Shh-associated medulloblastoma, and this has important implications for the cellular origin of human medulloblastomas. PMID:22349907

Grammel, Daniel; Warmuth-Metz, Monika; von Bueren, André O; Kool, Marcel; Pietsch, Torsten; Kretzschmar, Hans A; Rowitch, David H; Rutkowski, Stefan; Pfister, Stefan M; Schüller, Ulrich

2012-04-01

395

A biomechanical double sac (pericardium-Pebax) for specially shaped artificial ventricles: a computerized study to evaluate its mechanical and volumetric properties.  

PubMed

For original ovoid shaped artificial ventricles, a biomechanical double sac consisting of a biological sac (porcine pericardium) as the blood contact interface and a synthetic sac (Pebax 3533) as the mechanical support to assume systolic-diastolic dynamic constraints was conceived. The volumetric and mechanical properties were assessed with a three-dimensional modeling of Pebax sacs and computerized simulations of their systolic distortions for both right and left ventricular configurations. The stresses and strains of these sacs were represented as quantitative mappings for a maximum end-systolic state and were below the respective threshold values above which the Pebax material is jeopardized for permanent structure impairment. After fatigue tests applied on Pebax strips under the alleged working conditions of Pebax sacs, the material structure was unchanged and maintained its intrinsic mechanical properties. The theoretical maximum stroke volumes were 74.4 cm3 and 62.4 cm3 for the left and right ventricular configurations, respectively. With these mechanical and volumetric features, the biomechanical double sac concept was considered valid and could be provided for a consequent specific total artificial heart. PMID:9335368

Chatel, D; Delamare, L; Dang, P; Lebouvier, D; Trocherie, F

1997-10-01

396

Surgical pathology of adenocarcinoma arising in Barrett's esophagus. Analysis of 67 cases.  

PubMed

Numerous reviews of adenocarcinoma arising in Barrett's esophagus have been reported, but detailed pathologic findings or survival analysis have rarely been provided. This retrospective study analyzed 67 patients (mean age, 64 years; male-to-female ratio, 10:1) with an adenocarcinoma arising in Barrett's esophagus treated by surgical resection. Prevalence of smokers was 63%, alcohol users, 45%, and patients with hiatal hernia, 73%. Five patients had another synchronous cancer, and seven patients, previous esophageal surgery. Forty percent of the tumors were well differentiated, 31% moderately differentiated, 15% poorly differentiated, 7% mucinous, and 6% composed of signet-ring cells. Depth of invasion in the esophageal wall was limited to mucosa in 13% of cases and submucosa in 18%. Invasive adenocarcinomas extended to the muscular layer in 12% of cases, to adventitia in 33%, and to periesophageal tissue in 24%. Vascular and perineural neoplastic invasion was present in 67 and 38% of cases. Regional lymph node involvement and distant metastases were found in 51 and 9% of cases. Overall, 1-, 2-, and 5-year survival rates were 63, 41, and 32%, respectively. Five-year survival rate was significantly better for patients with superficial cancer limited to mucosa or submucosa (82 vs. 12%) or without regional lymph node involvement (59 vs. 10%). Tumor differentiation, vascular and perineural invasion, extranodal spread, distant metastases, and resection margins status also had a significant prognostic value on univariate analysis. In a multivariate Cox regression analysis for overall survival, depth of invasion in the esophageal wall and regional lymph node involvement were independent prognostic factors. Careful pathologic staging is of value in determining the prognosis of patients with adenocarcinoma arising in Barrett's esophagus. PMID:7832278

Paraf, F; Fléjou, J F; Pignon, J P; Fékété, F; Potet, F

1995-02-01

397

Relative investment in egg load and poison sac in fig wasps: Implications for physiological mechanisms underlying seed and wasp production in figs  

NASA Astrophysics Data System (ADS)

Fig pollinating wasps and most non-pollinator wasps apply secretions from their poison sacs into oviposited flowers that appear necessary to the formation of the galls that their developing offspring consume. Thus, both eggs and poison sac secretions appear to be essential for wasp reproduction, but the relative investment in each is unknown. We measured relative investment in poison sac and egg production in pollinating and non-pollinating wasps associated with seven species of monoecious Panamanian figs representing both active and passive pollination syndromes. We then collected similar data for four fig hosts in China, where some wasp species in the genus Eupristina have lost the ability to pollinate ("cheaters"). All wasps examined possessed large poison sacs, and we found a strong positive correlation between poison sac size and absolute egg production. In the Panamanian species, the relative poison sac to egg investment was highest in the externally ovipositing non-pollinator wasps, followed by active pollinators, then by passive pollinators. Further, pollinator wasps of fig species with demonstrated host sanctions against "cheating" wasps showed higher investment in the poison sac than wasps of species without sanctions. In the Chinese samples, relative investment in the poison sac was indistinguishable between pollinators and "cheaters" associated with the same fig species. We suggest that higher relative investment in poison sac across fig wasp species reflects higher relative difficulty in initiating formation of galls and subsequently obtaining resources from the fig. We discuss the implications for the stability of the fig–wasp mutualism, and for the ability of non-pollinators to exploit this mutualism.

Martinson, Ellen O.; Jandér, K. Charlotte; Peng, Yan-Qiong; Chen, Huan-Huan; Machado, Carlos A.; Arnold, A. Elizabeth; Herre, Edward Allen

2014-05-01

398

Results and validation of marine surface wind speed obtained from SAC-D/Aquarius MWR  

NASA Astrophysics Data System (ADS)

MWR (MicroWave Radiometer) is a radiometer on board SAC-D/Aquarius satellite, launched in June 2011. The SAC-D/Aquarius science mission was developed jointly by the Nacional Space Agency of Argentina (CONAE, Comisión Nacional de Actividades Espaciales) and the National Aeronautics and Space Administration of USA (NASA), that focuses on understanding the interaction between the global water cycle, ocean circulation and climate by measuring sea surface salinity. MWR is a three channel push broom, Dicke radiometer, that has 16 beams, 8 forward-looking at 36.5 GHz (in vertical and horizontal polarization) and 8 aft-looking at 23.8 GHz (in horizontal polarization), with a swath of approximately 380 Km. The beams are arranged to have two incidence angles, one of 52° (odd beams) and one of 58° (even beams) for both forward and aft-looks. Since recently, CONAE with collaboration of CFRSL (Central Florida Remote Sensing Laboratory), are generating geophysical parameters, all over the sea surface, using brightness temperature measurements from MWR. These parameters include columnar water vapor, wind speed, sea ice concentration and rain rate, which are ancillary data for the Aquarius salinity measurements. We present in this paper the first results of wind speed over the sea, obtained using the MWR data. The wind speed retrieval algorithm is based on the microwave radiative transfer theory by Wentz [1]. The algorithm developed uses MWR brigthness temperature at 36.5 GHz in both polarizations and sea surface temperature obtained from GDAS. As a result, the neutral stability ocean surface wind speed at 10 m height and the atmospheric trasnmissivity at 36.5 GHz are retrieved. In addition, a validation process in collaboration with the Naval Hydrographic Service of Argentina (SHN) has started. The final goal of this on-going work is to assess the quality of MWR wind data in conjunction with surface wind observations from other sources in a data assimilation system. At this first stage, MWR and WindSat collocated wind speed observations are analyzed. Here we show the preliminary validation statistics and considerations on possible sources of discrepancies and the room for improvements. [1] F.J.Wentz, "Measurements of oceanic wind speed vector using satellite microwave radiometer", IEEE Transaction on Geoscience Remote Sensing, vol. 30, pp.960-972, Sep. 1992.

Tauro, C. B.; Etala, P.; Echevarría, P.; Hejazin, Y.; Jacob, M. M.; Jones, L.

2012-12-01

399

N-cadherin Expression in Testicular Germ Cell and Gonadal Stromal Tumors  

PubMed Central

Neural-cadherin is a member of the cadherin gene family encoding the N-cadherin protein that mediates cell adhesion. N-cadherin is a marker of Sertoli cells and is also expressed in germ cells of varying stages of maturation. The purpose of this study was to determine the presence and distribution of this protein by immunohistochemistry in 105 germ cell tumors of both single and mixed histological types and 12 gonadal stromal tumors. Twenty-four germ cell tumors consisted of one cell type and the remaining were mixed. Of the 23 seminomas in either pure or mixed tumors, 74% were positive. Two spermatocytic seminomas were positive. Of the 83 cases with yolk sac tumor, 99% were positive for N-cadherin. The teratomas were positive in 73% in neuroectodermal and / or glandular components. In contrast, 87% of embryonal carcinomas did not express N-cadherin. Only 17% of the syncytiotrophoblastic cells were positive for N-cadherin. In conclusion, N-cadherin expression is very helpful in the identification of yolk sac tumors. In addition to glypican-3 and Sal-like protein 4, N-cadherin can be beneficial for the diagnosis and classification of this subtype of testicular germ cell tumor. Nine of the 12 gonadal stromal tumors were positive to a variable extent.

Heidenberg, Daniel J.; Barton, Joel H.; Young, Denise; Grinkemeyer, Michael; Sesterhenn, Isabell A.

2012-01-01

400

Solitary fibrous tumor of the thyroid gland.  

PubMed

Solitary fibrous tumor is a spindle cell neoplasm rarely arising in the thyroid gland. We present a 78-year-old man with the diagnosis of solitary fibrous tumor of the thyroid gland resected by subtotal thyroidectomy. Fine needle aspiration cytology via ultrasound guidance demonstrated a hypocellular aspirate that revealed follicular epithelial cells with mild nuclear atypia and scattered spindle cells with bland nuclei. Histologically, the patternless proliferation of spindle cells was seen among collagenous bundles, accompanied by hemangiopericytomatous vessels, and variously dilated follicles with mild atypical cells having slightly enlarged nuclei, indicating adenomatous goiter. The neoplastic spindle cells showed diffuse immunoreactivity to CD34, bcl-2, CD99 and vimentin, but were negative for cytokeratins, calcitonin, TTF-1 and CD5. Although solitary fibrous tumor arising in thyroid gland is rare, this tumor should be included in the differential diagnosis of thyroid spindle cell tumors and also that of adenomatous. PMID:24013381

Mizuuchi, Yusuke; Yamamoto, Hidetaka; Nakamura, Katsuya; Shirahane, Kengo; Souzaki, Masae; Tanaka, Masao; Oda, Yoshinao

2014-06-01

401

Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum  

Microsoft Academic Search

Mismatch repair (MMR) genes, such as Msh2, are classified as “mutator” genes, responsible for the microsatellite instability identified in many tumors. In the current study, the mutation frequency and mutational spectrum in thymic lymphoma arising in Msh2 deficient mice are investigated. Thymic lymphoma developed in Msh2?\\/? background displayed an eight to nine-fold increase in mutation frequency compared to the normal

Shulin Zhang; Ruth Lloyd; Gregory Bowden; Barry W Glickman; Johan G de Boer

2002-01-01

402

Carcinoid Tumors  

MedlinePLUS

Carcinoid tumors are rare, slow-growing cancers. They usually start in the lining of the digestive tract ... age of people diagnosed with digestive or lung carcinoids is about 60. In later stages the tumors ...

403

Mammary tumors  

SciTech Connect

Mammary neoplasia is one of the more common malignancies affecting domestic species. Despite their importance, they are often over- diagnosed, undertreated and subject to several misconceptions propagated by veterinarians and pet owners alike. Mammary neoplasia is the most frequent tumor type encountered in the female accounting for almost half of all malignancies reported. The canine has the highest incidence of mammary tumors of all domestic species. In the dog, about 65 percent of mammary tumors are benign mixed tumors, and 25 percent are carcinomas. The rest are adenomas, myoepitheliomas, and malignant mixed tumors. The age distribution of mammary tumors closely follows the age distribution of most tumors in the dog. Mammary tumors are rare in dogs 2 years old, but incidence begins to increase sharply at approximately 6 years of age. Median age at diagnosis is about 10 years. No breed predilection has been consistently reported.

Weller, R.E.

1988-10-01

404

Urogenital tumors  

SciTech Connect

An overview is provided for veterinary care of urogenital tumors in companion animals, especially the dog. Neoplasms discussed include tumors of the kidney, urinary bladder, prostate, testis, ovary, vagina, vulva and the canine transmissible venereal tumor. Topics addressed include description, diagnosis and treatment.

Weller, R.E.

1994-03-01

405

"Stealth" tumors  

PubMed Central

Breast cancers (BCs) comprise heterogeneous subtypes of various prognoses. An active anti-tumor immune profile usually correlated with a better survival. Two current major challenges of BC research are to understand the inter-relations between BC and anti-tumor immunity, and to identify candidates whose targeting would contribute to enhance anti-tumor efficiency.

Mamessier, Emilie; Bertucci, Francois; Sabatier, Renaud; Birnbaum, Daniel; Olive, Daniel

2012-01-01

406

[Perihilar cholangiocarcinoma (Klatskin tumor)].  

PubMed

Perihilar cholangiocarcinoma or Klatskin tumors are a rare entity arising from the extrahepatic bile duct bifurcation. Considering the close anatomical relationship of the bile duct bifurcation with the portal vein bifurcation and hepatic arteries, surgical treatment is demanding. With an incidence of only 2-4 cases/100,000 population/year patients should be referred to a specialized center. The tumors are usually poorly differentiated adenocarcinomas growing diffusely along the duct and also the perineural sheath. Only radical surgery offers a curative option and currently surgical strategy usually consists of en bloc resection of the bile duct, extended liver resection and portal vein resection. Proximal and lateral safety margin R0 resections are technically very demanding procedures because of the local anatomy. PMID:24464335

Stavrou, G A; Donati, M; Faiss, S; Jenner, R M; Niehaus, K J; Oldhafer, K J

2014-02-01

407

Development of a broad-host-range sacB-based vector for unmarked allelic exchange  

PubMed Central

Background Although genome sequences are available for an ever-increasing number of bacterial species, the availability of facile genetic tools for physiological analysis have generally lagged substantially behind traditional genetic models. Results Here I describe the development of an improved, broad-host-range "in-out" allelic exchange vector, pCM433, which permits the generation of clean, marker-free genetic manipulations. Wild-type and mutant alleles were reciprocally exchanged at three loci in Methylobacterium extorquens AM1 in order to demonstrate the utility of pCM433. Conclusion The broad-host-range vector for marker-free allelic exchange described here, pCM433, has the advantages of a high copy, general Escherichia coli replicon for easy cloning, an IncP oriT enabling conjugal transfer, an extensive set of restriction sites in its polylinker, three antibiotic markers, and sacB (encoding levansucrase) for negative selection upon sucrose plates. These traits should permit pCM433 to be broadly applied across many bacterial taxa for marker-free allelic exchange, which is particularly important if multiple manipulations or more subtle genetic manipulations such as point mutations are desired.

Marx, Christopher J

2008-01-01

408

Glucose transport into everted sacs of the small intestine of mice.  

PubMed

The Na(+)-glucose cotransporter is a key transport protein that is responsible for absorbing Na(+) and glucose from the luminal contents of the small intestine and reabsorption by the proximal straight tubule of the nephron. Robert K. Crane originally described the cellular model of absorption of Na(+) and glucose by a "cotransport process" in 1960. Over the past 50+ yr, numerous groups have tested and verified Crane's hypothesis. Eventually, Wright and colleagues cloned the Na(+)-glucose cotransporter (SGLT1; the product of the SLC5A1 gene) in 1987. This article provides a "hands-on" laboratory exercise using the everted mouse jejunal preparation (everted sac) that allows students to investigate various components of the Na(+)-glucose cotransport absorptive cell model (e.g., Na(+) dependence of SGLT1, inhibition of SGLT1, and inhibition of Na(+)-K(+)-ATPase). Additionally, the laboratory exercise includes a case-based study of glucose-galactose malabsorption in which the students conduct an internet search and participate in a small-group discussion during the laboratory period to better understand the basic principles and functions of the Na(+)-glucose absorptive process of the small intestine. This laboratory exercise was introduced into the second-year undergraduate physiology curriculum in 2008, and >850 physiology students have participated in this laboratory exercise. The students have produced very robust and reproducible data that clearly illustrate the theory of the cellular model for Na(+)-glucose absorption by the jejunum. PMID:24292921

Hamilton, Kirk L; Butt, A Grant

2013-12-01

409

Absorption mechanism of polaprezinc (zinc L-carnosine complex) by an everted sac method.  

PubMed

1. The absorption mechanism of polaprezinc (zinc-carnosine chelate compound) was studied in rat by an everted gut sac method. The rates of transport and accumulation of 14C-L-carnosine were proportional to the mucosal concentration of L-carnosine, whereas the rates of transport and accumulation of 65ZnCl2 had become saturated. The Michaelis-Menten constant (Km) = 4.41 mM and maximal rate (Vmax) = 71.83 nmol/min/g for zinc transport and, similarly, Km = 6.21 mM and Vmax = 92.51 mumol/30 min/g for accumulation. 2. The addition of ouabain, 2,4-dinitrophenol (2,4-DNP) and low temperatures reduced the rate of zinc uptake, indicating that zinc transport was considered to be a carrier-mediated process based on Na+,K(+)-ATPase-dependent mechanisms. 3. The concentration of zinc in the gut of the non-fasted rat was greater than that of the fasted rat, suggesting different rates of transport and accumulation. It is suggested that zinc intestinal uptake in rat is regulated by zinc content in the gut. 4. A pharmacokinetic model for transport and accumulation of zinc saturation from the lumen side to the gut was designed, and the calculated values obtained by simultaneous multiline fitting of transport and accumulation of zinc data were in good agreement with the observed values. PMID:7701850

Furuta, S; Toyama, S; Sano, H

1994-11-01

410

Integrated Phase Array Antenna/Solar Cell System for Flexible Access Communication (IA/SAC)  

NASA Technical Reports Server (NTRS)

This paper describes recent efforts to integrate advanced solar cells with printed planar antennas. Several previous attempts have been reported in the literature, but this effort is unique in several ways. It uses Gallium Arsenide (GaAs) multi-junction solar cell technology. The solar cells and antennas will be integrated onto a common GaAs substrate. When fully implemented, IA/SAC will be capable of dynamic beam steering. In addition, this program targets the X-band (8 - 12 GHz) and higher frequencies, as compared to the 2.2 - 2.9 GHz arrays targeted by other organizations. These higher operating frequencies enable a greater bandwidth and thus higher data transfer rates. The first phase of the effort involves the development of 2 x 2 cm GaAs Monolithically Integrated Modules (MIM) with integrated patch antennas on the opposite side of the substrate. Subsequent work will involve the design and development of devices having the GaAs MIMs and the antennas on the same side of the substrate. Results from the phase one efforts will be presented.

Clark, E. B.; Lee, R. Q.; Pal, A. T.; Wilt, D. M.; McElroy, B. D.; Mueller, C. H.

2005-01-01

411

Mass-marking of otoliths of lake trout sac fry by temperature manipulation  

USGS Publications Warehouse

The otoliths of 676,000 sac fry of lake trout Salvelinus namaycush in 1986, and of 1,100,000 in 1987, were marked by daily manipulation of water temperature. The fish were stocked into Lake Huron in the spring. Otolith marks consisted of groups of daily growth rings accentuated into recognizable patterns by steadily raising and lowering the temperature about IOA?C (from a base of 1-4A?C) over 14h. In 1987, groups of marked and control fish were held for 6 months. The otoliths were removed from samples of the fish, embedded in epoxy, thin-sectioned by grinding in the sagittal plane, etched, and viewed by using a combination of a compound microscope (400-1000x) and a video enhancement system. One or more readable otolith sections were obtained from 39 of a sample of 40 fish. Three independent readers examined 41 otoliths for marks and correctly classified the otoliths, with accuracies of 85, 98,and 100%, as being from marked or unmarked fish. The exact number of rings in a recognizable pattern sometimes differed from the number of temperature cycles to which the fish were exposed. Counts of daily rings within groups of six rings varied less than counts within groups of three rings.

Bergstedt, R. A.; Eshenroder, R. L.; Bowen, C. II; Seelye, J. G.; Locke, J. C.

1990-01-01

412

Mass-marking of otoliths of lake trout sac fry by temperature manipulation  

USGS Publications Warehouse

The otoliths of 676,000 sac fry of lake trout Salvelinus namaycush in 1986, and of 1,100,000 in 1987, were marked by daily manipulation of water temperature. The fish were stocked into Lake Huron in the spring. Otolith marks consisted of groups of daily growth rings accentuated into recognizable patterns by steadily raising and lowering the temperature about 10 degrees C (from a base of 1-4 degrees C) over 14 h. In 1987, groups of marked and control fish were held for 6 months. The otoliths were removed from samples of the fish, embedded in epoxy, thin sectioned by grinding in the sagittal plane, etched, and viewed by using a combination of a compound microscope (400-1000x) and a video enhancement system. One or more readable otolith sections were obtained from 39 of a sample of 40 fish. Three independent readers examined 41 otoliths for marks and correctly classified the otoliths, with accuracies of 85, 98, and 100%, as being from marked or unmarked fish. The exact number of rings in a recognizable pattern sometimes differed from the number of temperature cycles to which the fish were exposed. Counts of daily rings within groups of six rings varied less than counts within groups of rings.

Bergstedt, Roger A.; Eshenroder, Randy L.; Bowen, Charles; Seelye, James G.; Locke, Jeffrey C.

1990-01-01

413

Effect of Gold Content on the Microstructural Evolution of SAC305 Solder Joints Under Isothermal Aging  

NASA Astrophysics Data System (ADS)

Au over Ni on Cu is a widely used printed circuit board (PCB) surface finish, under bump metallization (UBM), and component lead metallization. It is generally accepted that less than 3 wt.% Au in Sn-Pb solder joints inhibits formation of detrimental intermetallic compounds (IMC). However, the critical limit for Au content in Pb-free solder joints is not well established. Three surface-mount package platforms, one with a matte Sn surface finish and the others with Ni/Au finish, were soldered to Ni/Au-finished PCB using Sn-3.0Ag-0.5Cu (SAC305) solder, in a realistic manufacturing setting. The assembled boards were divided into three groups: one without any thermal treatment, one subjected to isothermal aging at 125°C for 30 days, and the third group aged at 125°C for 56 days. Representative solder joints were cross-sectioned and analyzed using scanning electron microscopy (SEM) and energy-dispersive x-ray spectroscopy (EDX) to investigate the evolution of the solder joint morphology as a function of Au content and isothermal aging. It was found that, if Cu is available to dissolve in the solder joint, the migration of AuSn4 from the bulk to the interface as a result of thermal aging is mitigated.

Powers, Mike; Pan, Jianbiao; Silk, Julie; Hyland, Patrick

2012-02-01

414

Noninvasive evaluation of the effect of endolymphatic sac decompression in Ménière's disease using magnetic resonance imaging.  

PubMed

Abstract Conclusions: This study is the first to demonstrate noninvasive evaluation of the effect of endolymphatic sac decompression (ESD) in Ménière's disease using magnetic resonance imaging (MRI). Objective: To evaluate the effect of ESD for the treatment of Ménière's disease by applying noninvasive intratympanic gadolinium (Gd) perfusion through the eustachian tube and three-dimensional fluid-attenuated inversion MRI (3D-FLAIR MRI). Methods: This was a prospective study. 3D-FLAIR MRI was performed with a 3 Tesla unit 24 h after intratympanic administration of Gd through the eustachian tube in five patients with intractable Ménière's disease before and 3 months after ESD, with a 2-year follow-up on the effect of ESD. Results: Gd was present in the perilymph of the inner ear in all the patients, which clearly displayed the endolymphatic space on 3D-FLAIR MRI with a visible borderline between the perilymph and the endolymph. According to the normal values for the endolymphatic space, four of five patients had a ratio of more than 26% in the cochlea, and three of five patients had a ratio of more than 41% in the vestibule preoperatively. All the patients had a ratio of less than 26% in the cochlea and 41% in the vestibule postoperatively. ESD was effective in reducing the incidence and severity of vertigo attacks with significant improvement in 60% of patients. PMID:24847946

Liu, Fang; Huang, Weining; Chen, Qinghua; Meng, Xixi; Wang, Zhenchang; He, Yuxia

2014-07-01

415

[An implantable micro-device using wireless power transmission for measuring aortic aneurysm sac pressure].  

PubMed

In order to detect endoleaks after endovascular aneurysm repair (EVAR), we developed an implantable micro-device based on wireless power transmission to measure aortic aneurysm sac pressure. The implantable micro-device is composed of a miniature wireless pressure sensor, an energy transmitting coil, a data recorder and a data processing platform. Power transmission without interconnecting wires is performed by a transmitting coil and a receiving coil. The coupling efficiency of wireless power transmission depends on the coupling coefficient between the transmitting coil and the receiving coil. With theoretical analysis and experimental study, we optimized the geometry of the receiving coil to increase the coupling coefficient. In order to keep efficiency balance and satisfy the maximizing conditions, we designed a closed loop power transmission circuit, including a receiving voltage feedback module based on wireless communication. The closed loop improved the stability and reliability of transmission energy. The prototype of the micro-device has been developed and the experiment has been performed. The experiments showed that the micro-device was feasible and valid. For normal operation, the distance between the transmitting coil and the receiving coil is smaller than 8cm. Besides, the distance between the micro-device and the data recorder is within 50cm. PMID:24059044

Guo, Xudong; Ge, Bin; Wang, Wenxing

2013-08-01

416

Apospory appears to accelerate onset of meiosis and sexual embryo sac formation in sorghum ovules  

PubMed Central

Background Genetically unreduced (2n) embryo sacs (ES) form in ovules of gametophytic apomicts, the 2n eggs of which develop into embryos parthenogenetically. In many apomicts, 2n ES form precociously during ovule development. Whether meiosis and sexual ES formation also occur precociously in facultative apomicts (capable of apomictic and sexual reproduction) has not been studied. We determined onset timing of meiosis and sexual ES formation for 569 Sorghum bicolor genotypes, many of which produced 2n ES facultatively. Results Genotype differences for onset timing of meiosis and sexual ES formation, relative to ovule development, were highly significant. A major source of variation in timing of sexual germline development was presence or absence of apomictic ES, which formed from nucellar cells (apospory) in some genotypes. Genotypes that produced these aposporous ES underwent meiosis and sexual ES formation precociously. Aposporous ES formation was most prevalent in subsp. verticilliflorum and in breeding lines of subsp. bicolor. It was uncommon in land races. Conclusions The present study adds meiosis and sexual ES formation to floral induction, apomictic ES formation, and parthenogenesis as processes observed to occur precociously in apomictic plants. The temporally diverse nature of these events suggests that an epigenetic memory of the plants' apomixis status exists throughout its life cycle, which triggers, during multiple life cycle phases, temporally distinct processes that accelerate reproduction.

2011-01-01

417

Impact of new technology weapons on SAC (Strategic Air Command) conventional air operations. Research report  

SciTech Connect

Chapter I introduces the issue of conventional-response capability. The point stressed first is that the strategic bomber's primary mission is in support of the single integrated operations plan (SIOP) as a nuclear weapons delivery vehicle. However, as cited by Secretary of Defense Caspar Weinberger, we must have a rapid deployment conventional capability to areas where there are small if any U.S. forces present. The SAC strategic projection force (SPF) is available but with gravity weapons of World War II vintage. New technology can provide answers to the problem by providing highly accurate long-range conventional standoff weapons. Chapter II gives a basic historical perspective on the use of the strategic bomber in past wars. It discusses the development of strategy, weapons, and targets in World War II, Korean War, and Vietnam War. Chapter III presents a very brief look at current US policy, strategy, and guidance. Chapter IV covers the aircraft attrition issue in today's highly lethal defensive environment. Chapter V describes the development of air-to-ground weapons. Chapter VI addresses the potential for the future in the shifting balance of Soviet and US technology. The final chapter makes the point that a decision must be made on weapons-acquisition programs and bomber force structure. New technology-standoff conventional weapons could make AAA and SAM defenses a modern Maginot Line.

Bodenheimer, C.E.

1983-06-01

418

Solid pseudo papillary tumor of the pancreas: An unusual tumor in children  

PubMed Central

An 11-year-old girl with a pancreatic solid pseudo papillary tumor (SPT) is reported. Contrast enhanced computerized tomography (CECT) & Magnetic resonant imaging (MRI) abdomen revealed a well-defined inhomogenous mass arising from the retro-peritoneum in the left upper quadrant of the abdomen possibly from the tail of the pancreas. USG guided biopsy of tumor showed benign pseudo papillary tumor of pancreas. Complete excision of the tumor was carried out. Histopathology revealed pancreatic pseudo papillary tumor. Patient did well postoperatively & is on regular follow-up

Parelkar, Sandesh V.; Oak, Sanjay N.; Kapadnis, Satish P.; Sanghvi, Beejal V.; Joshi, Prashant B.; Sathe, Pragati; Mundada, Dinesh; Shetty, Shishira

2013-01-01

419

Accessory muscular bundles arising from biceps femoris muscle.  

PubMed

Two kinds of accessory muscle bundles arising from the long head of the biceps femoris muscle were encountered in a 20-year-old Turkish female cadaver during routine dissections. The one occurred on both sides, each arising from the lower portion of the long head of the muscle and passed deep to the fascia of the popliteal fossa to be inserted into the crural fascia. The other one which was observed only on the right side, arose from the upper portion of this head to be inserted into the semitendinosus muscle. PMID:7645372

Sinav, A; Gümü?alan, Y; Arifo?lu, Y; Ondero?lu, S

1995-06-01

420

Adenocarcinoma Arising in a Duplication of the Cecum  

PubMed Central

Intestinal duplications are rare developmental abnormalities that may occur anywhere in the gastrointestinal tract. The possibility of a malignant change occurring in these duplications is very low. We present a case of adenocarcinoma arising in a duplication of the cecum. A 41-year-old male patient was admitted because of a palpable abdominal mass. Abdominal computed tomography revealed a 6-cm, peripheral wall-enhanced, round, cystic mass in the cecal area. Excision of the mesenteric mass and a right hemicolectomy was performed. Upon histologic examination, the patient was diagnosed with adenocarcinoma arising in a duplication of the cecum.

Jung, Kyong-Hee; Jang, Se-Min; Joo, Yong-Won; Oh, Young-Ha; Park, Young-Wook; Paik, Hong-Gyu

2012-01-01

421

Take time to smell the frogs: vocal sac glands of reed frogs (Anura: Hyperoliidae) contain species-specific chemical cocktails  

PubMed Central

Males of all reed frog species (Anura: Hyperoliidae) have a prominent, often colourful, gular patch on their vocal sac, which is particularly conspicuous once the vocal sac is inflated. Although the presence, shape, and form of the gular patch are well-known diagnostic characters for these frogs, its function remains unknown. By integrating biochemical and histological methods, we found strong evidence that the gular patch is a gland producing volatile compounds, which might be emitted while calling. Volatile compounds were confirmed by gas chromatography–mass spectrometry in the gular glands in 11 species of the hyperoliid genera Afrixalus, Heterixalus, Hyperolius, and Phlyctimantis. Comparing the gular gland contents of 17 specimens of four sympatric Hyperolius species yielded a large variety of 65 compounds in species-specific combinations. We suggest that reed frogs might use a complex combination of at least acoustic and chemical signals in species recognition and mate choice.

STARNBERGER, IRIS; POTH, DENNIS; PERAM, PARDHA SARADHI; SCHULZ, STEFAN; VENCES, MIGUEL; KNUDSEN, JETTE; BAREJ, MICHAEL F.; RODEL, MARK-OLIVER; WALZL, MANFRED; HODL, WALTER

2013-01-01

422

Motor control of sound frequency in birdsong involves the interaction between air sac pressure and labial tension  

PubMed Central

Frequency modulation is a salient acoustic feature of birdsong. Its control is usually attributed to the activity of syringeal muscles, which affect the tension of the labia responsible for sound production. We use experimental and theoretical tools to test the hypothesis that for birds producing tonal sounds such as domestic canaries (Serinus canaria), frequency modulation is determined by both the syringeal tension and the air sac pressure. For different models, we describe the structure of the isofrequency curves, which are sets of parameters leading to sounds presenting the same fundamental frequencies. We show how their shapes determine the relative roles of syringeal tension and air sac pressure in frequency modulation. Finally, we report experiments that allow us to unveil the features of the isofrequency curves.

Alonso, Rodrigo; Goller, Franz; Mindlin, Gabriel B.

2014-01-01

423

Motor control of sound frequency in birdsong involves the interaction between air sac pressure and labial tension.  

PubMed

Frequency modulation is a salient acoustic feature of birdsong. Its control is usually attributed to the activity of syringeal muscles, which affect the tension of the labia responsible for sound production. We use experimental and theoretical tools to test the hypothesis that for birds producing tonal sounds such as domestic canaries (Serinus canaria), frequency modulation is determined by both the syringeal tension and the air sac pressure. For different models, we describe the structure of the isofrequency curves, which are sets of parameters leading to sounds presenting the same fundamental frequencies. We show how their shapes determine the relative roles of syringeal tension and air sac pressure in frequency modulation. Finally, we report experiments that allow us to unveil the features of the isofrequency curves. PMID:24730873

Alonso, Rodrigo; Goller, Franz; Mindlin, Gabriel B

2014-03-01

424

Benign and malignant tumors of the rectum and perirectal region.  

PubMed

Although most rectal masses are histologically characterized as adenocarcinomas, the rectum and perirectal region can be affected by a wide variety of tumors and tumor-like conditions that can mimic the symptoms caused by rectal adenocarcinoma, including mucosal or submucosal rectal tumors such as lymphoma, gastrointestinal stromal tumor, leiomyosarcoma, neuroendocrine tumor, hemangioma, and melanoma, as well as tumors of the perirectal region such as developmental cyst, neurogenic tumor, osseous tumor, and other miscellaneous conditions. As a group, tumors of the rectum are considerably different from the group of tumors that arise in the perirectal region: they are most often neoplastic, symptomatic, and malignant, whereas tumors arising in the perirectal region are most commonly congenital, asymptomatic, and benign. Proctoscopy with biopsy is the most important method for the diagnosis of rectal tumors, but this procedure cannot determine the precise intramural extension of a rectal tumor and cannot accurately distinguish submucosal and intramural tumors from extramural tumors. Cross-sectional imaging, especially transrectal ultrasound and magnetic resonance imaging, allows evaluation of the entire bowel wall thickness and the perirectal tissues, helping further characterize these tumors. Recognition of the existence of these masses and their key clinical and imaging features is crucial for clinicians to accurately diagnose and appropriately manage these conditions. PMID:24663381

Purysko, Andrei S; Coppa, Christopher P; Kalady, Mathew F; Pai, Rish K; Leão Filho, Hilton M; Thupili, Chakradhar R; Remer, Erick M

2014-08-01

425

Wilms tumor: an update.  

PubMed

Wilms tumor (WT) is the most common neoplasm of the kidney in children. It is an embryologic tumor that histologically mimics renal embryogenesis and is composed of a variable mixture of stromal, blastemal, and epithelial elements. Nephrogenic rests, generally considered to be precursor lesions of the WT, are foci of the embryonic metanephric tissue that persist after the completion of renal embryogenesis. These are classified as perilobar and intralobar based on their location and maybe present as single or multiple foci. Intralobar and perilobar rests and the tumors arising from these rests differ morphologically and are characterized by 2 different sets of genetic abnormalities involving 2 adjacent foci, WT1 and WT2, on the short arm of chromosome 11. WTs arising in the intralobar rests tend to be stromal predominant and have a mutation or deletion of WT1. Germline mutation in WT1 may be associated with syndromic conditions such as WAGR and Denys-Drash syndromes. Perilobar rests and their corresponding tumors usually have loss of imprinting/loss of heterozygosity involving WT2, which contains several parentally imprinted genes. Loss of function of these genes, if present constitutionally, may be associated with Beckwith-Wiedemann syndrome or may result in isolated hypertrophy. Abnormalities in several other genes may also be seen in WT. These include WTX, (on chromosome X), CTNNB1 (chromosome 3), and TP53 (chromosome 17) among others. WT with loss of heterozygosity at 1p and 16q may have poor prognosis, requiring aggressive therapy. Treatment modalities for WT have evolved over many decades, primarily through the efforts of Dr J Bruce Beckwith at National WT study. This work is now being carried out by Children Oncology Group in North America and International Society of Pediatric Oncology in Europe. Although their therapeutic approaches are somewhat different, both have reported excellent results with equally high cure rates. PMID:24713986

Al-Hussain, Turki; Ali, Afshan; Akhtar, Mohammed

2014-05-01

426

Pre-labor silent rupture of unscarred uterus at 32 weeks with intact amniotic sac extrusion: a case report  

Microsoft Academic Search

INTRODUCTION: Spontaneous rupture of uterus in unscarred uterus prior to onset of labor in third trimester is extremely rare and to our knowledge, very few cases have been reported so far. CASE PRESENTATION: A 26-year-old third gravida women with 32 weeks pregnancy presented with pre-labor rupture uterus with extrusion of intact amniotic sac from the rent in uterine fundus. CONCLUSION:

Ritu Rana; Manju Puri

2009-01-01

427

Support to Aviation Control Service (SACS): an online service for near-real-time satellite monitoring of volcanic plumes  

NASA Astrophysics Data System (ADS)

Volcanic eruptions emit plumes of ash and gases into the atmosphere, potentially at very high altitudes. Ash-rich plumes are hazardous for airplanes as ash is very abrasive and easily melts inside their engines. With more than 50 active volcanoes per year and the ever-increasing number of commercial flights, the safety of airplanes is a real concern. Satellite measurements are ideal for monitoring global volcanic activity and, in combination with atmospheric dispersion models, to track and forecast volcanic plumes. Here we present the Support to Aviation Control Service (SACS, sacs.aeronomie.be/ecosystem"_target="blank">http://sacs.aeronomie.be/ecosystem), which is a free online service initiated by the European Space Agency (ESA) for the near-real-time (NRT) satellite monitoring of volcanic plumes of SO2 and ash. It combines data from three ultraviolet (UV)-visible and three infrared (IR) spectrometers. The UV-vis sensors are the Ozone Monitoring Instrument (OMI) and the Global Ozone Monitoring Experiment-2 (GOME-2) on-