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1

"Somatic-type" malignancies arising from testicular germ cell tumors: a clinicopathologic study of 124 cases with emphasis on glandular tumors supporting frequent yolk sac tumor origin.  

PubMed

Somatic-type malignancies (SMs) in patients with testicular germ cell tumors (GCT) are rare and mostly attributed to "transformation" of teratoma, although yolk sac tumor (YST) origin has also been proposed. We studied 124 cases of "SM" of testicular GCT origin from 106 patients to evaluate their morphology, immunohistochemical features (especially the utility of SALL4), and relationship to YST. Primitive neuroectodermal and nephroblastomatous tumors were excluded because of prior studies. Patients ranged in age from 15 to 68 years (mean, 33 y). The tumors ranged from 0.7 to 30 cm (mean, 7.6 cm) and involved the retroperitoneum (64%), abdomen/pelvis (10%), lung (10%), mediastinum (6%), supraclavicular region/neck (4%), testis (4%), and thigh (1%). Most initial diagnoses were sarcomas (n=68) or carcinomas (n=51). On review and immunohistochemical analysis, 7 of 45 adenocarcinomas were reclassified as glandular YSTs (GYST) on the basis of glypican-3 (GPC3) and/or ?-fetoprotein positivity and scant/absent reactivity for EMA and CK7. These occasionally (29%) had subnuclear and sometimes supranuclear vacuoles (endometrioid-like), whereas adenocarcinomas were more frequently mucinous (17%) or enteric-type (11%) than endometrioid-like (9%). Both expressed CDX2 frequently (83% and 63%, respectively). MUC protein 2, 4, 5, and 6 expression was more common in adenocarcinomas (7% to 36%) than in GYSTs (0% to 20%) but was infrequent. Both were often positive for SALL4, BerEP4, and MOC31; all were negative for TTF-1. On follow-up (GYST: range, 23 to 169 mo; mean, 81mo; adenocarcinoma: range, 1 to 170 mo; mean, 55 mo), 50% and 33% of patients with GYST and adenocarcinoma, respectively, died of disease. We reclassified 26 of 76 sarcomatoid tumors as sarcomatoid YSTs (SYST) on the basis of positive reactivity for both AE1/3 and GPC3. These tumors often had spindled and epithelioid cells in a fibromyxoid stroma. SYSTs were often (60%) SALL4 positive, whereas sarcomas were all negative. On follow-up (SYST: range, 1 to 259 mo; mean, 62 mo; sarcoma: range, 1 to 327 mo; mean, 70 mo), 50% and 29% of patients with SYST and sarcoma, respectively, died of disease, with most mortality occurring in those with high-grade tumors. We conclude that, on the basis of a panel of immunoreactivities, a significant number of "SMs" in testicular GCT patients are more accurately classified as either GYSTs or SYSTs. Ambiguous glandular tumors should be evaluated for GPC3, ?-fetoprotein, CK7, and EMA reactivity and sarcomatoid ones for GPC3, AE1/3, and SALL4 reactivity. PMID:24921638

Magers, Martin J; Kao, Chia-Sui; Cole, Cristina D; Rice, Kevin R; Foster, Richard S; Einhorn, Lawrence H; Ulbright, Thomas M

2014-10-01

2

Papillary endolymphatic sac tumor: a case report.  

PubMed

Glandular tumors involving the middle ear are rare and distinguishing between adenoma and adenocarcinoma remains difficult. A distinct subclass of these tumors demonstrates microscopic papillary architecture and has a propensity to erode the petrous bone and extend intracranially. The term "aggressive papillary middle ear tumor" has recently been proposed to describe this more invasive type of middle ear tumor. These tumors cause symptoms even when microscopic in size. Although histologically benign, they have been locally destructive with frequent intracranial extension and patients may die of uncontrolled local disease. These tumors do not metastasize but there is single case report of drop metastasis to the spine in the literature. Hence this tumor must be distinguished from other benign tumors of the middle ear. These rare neoplasms constitute a distinct pathological entity and deserve wider recognition. PMID:22953101

Arava, S; Soumya, R M; Chitragar, S; Safaya, R; Chandrashekhar, S H; Thakar, Alok

2012-01-01

3

Mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma.  

PubMed

We report the case of a 19-year-old woman experiencing lower abdominal distension and pain. Laboratory tests indicated elevated serum levels of Alpha-Fetoprotein (AFP) and human Chorionic Gonadotropin (hCG). A large mass was detected in the abdomen by physical examination and by transvaginal ultrasonography. Exploratory laparotomy was performed, and a smooth-surfaced, spherical, solid tumor was found on the left ovary, measuring 11.5 x 9.9 x 6.9 cm. Histological evaluation revealed that the tumor consisted of a combination of immature teratoma, Yolk Sac Tumor, and embryonal carcinoma; this is a very rare combination in mixed germ cell tumors. PMID:25518772

Wang, Ying; Zhou, Feng; Qian, Zhida; Qing, Jiale; Zhao, Mengdam; Huang, Lili

2014-11-01

4

Laparoscopic treatment of a Yolk Sac Tumor: case report and literature review  

PubMed Central

SUMMARY We report the case of a yolk sac tumor of the ovary in a 26 years old woman. The laparoscopic approach and the BEP chemotherapy were fundamental to have a minimally invasive treatment and to preserve fertility. PMID:24251245

Guida, Maurizio; Pignata, Sandro; Palumbo, Anna Rita; Miele, Gianmarco; Marra, Maria Luisa; Visconti, Federica; Zullo, Fulvio

5

Giant cell tumor arising from anterior arc of the rib.  

PubMed

A primary giant cell tumor of the rib is very rare. The most common site of a giant cell tumor arising from the rib is the posterior arc. A giant cell tumor arising from the anterior arc of the rib is extremely rare. The treatment of a giant cell tumor of the rib is not well defined. Generally, a complete surgical resection is performed in a patient with a primary giant cell tumor of the rib. We report a case of a giant cell tumor arising from the anterior arc of the rib that was treated with a wide excision and chest wall reconstruction. PMID:24175276

Heo, Woon; Kang, Do Kyun; Min, Ho-Ki; Jun, Hee Jae; Hwang, Youn-Ho

2013-10-01

6

MR imaging findings of extraovarian endocervical mucinous borderline tumors arising from pelvic endometriosis.  

PubMed

We report MR imaging findings of a rare case of endocervical mucinous borderline tumor (MBT) involving the cul-de-sac and left fallopian tube arising from extensive pelvic endometriosis with pathologic correlation in a 35-year-old woman presented with vague pelvic pain. Endocervical MBT is a type of endometriosis-associated carcinoma. Imaging findings of endocervical MBT are unilocular or oligolocular cystic lesions with enhancing mural nodules, which are different from those of the more common intestinal type MBT. PMID:24265567

Yeo, Dong Myung; Rha, Sung Eun; Byun, Jae Young; Lee, Ahwon; Kim, Mee-Ran

2013-01-01

7

Tenosynovial Giant Cell Tumor Arising on the Scapular Region  

PubMed Central

Tenosynovial giant cell tumor (TSGCT) is a benign soft tissue tumor arising from the synovial membrane that composes the lining of joints, tendons and bursae. TSGCT is a common tumor occurring in the hands and fingers, and also consecutively in the knees, ankles, feet and hips. It is rarely found in the scapular region. To the best of our knowledge, only 2 cases arising on the upper back have been reported. This report presents the case of a 44-year-old Japanese female with a TSGCT arising on her right scapular region. PMID:24403889

Fukuda, Asako; Ueno, Takashi; Takayama, Ryoko; Ansai, Shin-ichi; Futagami, Ayako; Kawana, Seiji

2013-01-01

8

Bilateral ovarian mixed epithelial adenocarcinoma in a postmenopausal woman with unilateral ovarian yolk sac tumor component  

PubMed Central

Ovarian yolk sac tumors (YSTs) usually occur in the young women and have been rarely documented in perimenopausal and postmenopausal women. The different age distribution supposes their complex nomenclature and histogenesis. We report a case of bilateral ovarian epithelial carcinoma with right ovarian YST component in a postmenopausal woman. The patient was treated by surgery and adjuvant combination chemotherapy of taxol and carboplatin for 6 courses and has been clinically free of tumor for 6 months. The correlation between the YST and the epithelial components always confuse us. Ovarian yolk sac tumors are not a discrete entity and represent a multifaceted group of neoplasms. The conjunction of multi antibodies help in differential diagnoses. In addition to a thorough case description, the literature concerning this entity is reviewed and discussed. PMID:25550883

Chen, Qin; Chen, Xiaoduan

2014-01-01

9

Intracranial tumors arising from the floor of the middle fossa  

Microsoft Academic Search

Tumors involving or arising from the floor of the middle fossa in cases seen at the Neurological Institute C. Besta were reviewed, and the radiological findings of plain films, angiographic and CT studies are described. Meningiomas, metastases, trigeminal neurinomas, epidermoids, chordomas and chondromas were included in the study.

M. A. Vaghi; M. G. Bruzzone; A. Visciani; A. Passerini

1985-01-01

10

Giant intracranial granular-cell tumor arising from the abducens.  

PubMed

We present a case of an adolescent with a giant intracranial granular-cell tumor, who presented with diplopia and worsening visual acuity. The tumor measured 8.2 cm at the maximum diameter and occupied the right middle cranial fossa, with intrasellar and suprasellar involvement. It was composed of solid nests of oval or polygonal eosinophilic cells with a focal pseudo-papillary configuration. Pituitary macroadenoma was suspected from examination of the intraoperative frozen section, but immunohistochemical and ultrastructural findings were consistent with granular-cell tumor, and they suggested the origin to be the peripheral nerve sheath. Considering that abducens palsy was the first clinical manifestation, the tumor was thought to arise from abducens. From histological findings (focal cellular spindling, mitotic activity and a relatively high Ki-67 labeling index [10.1%]) and according to Fanburg-Smith's criteria, the tumor was suspected to have low-grade malignant potential. Granular-cell tumor should be included in the differential diagnosis of parasellar tumors, even in young patients or patients with large lesions. Both immunohistochemical and electron microscopic studies are essential for diagnosis. PMID:11422812

Ogata, S; Shimazaki, H; Aida, S; Miyazawa, T; Tamai, S

2001-06-01

11

Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell.  

PubMed

A 21-year-old lady diagnosed with Stage 3 ovarian yolk sac tumor (YST) underwent primary cytoreductive fertility sparing surgery, followed by conventional courses of platinum-based chemotherapy and etoposide. Recurrence at cul-da-sac was noted after a short period of remission and secondary debulking performed followed by four cycles of conventional chemotherapy. The patient's disease progressed despite courses of treatments. A joint team management including a hematologist was commenced following the failure of conventional chemotherapies. Two cycles of high-dose chemotherapy (HDCT) with ifosfamide/cisplatin/etoposide (ICE) regimen, followed by autologous stem cell transplantation (ASCT) were given. With this salvage treatment, she remained in complete remission and disease-free for more than 30 months, while maintaining her reproductive function. These approaches appear to be effective as a salvage treatment in selected cases of patients with ovarian germ cell tumor, especially those who failed primary conventional chemotherapy. PMID:23781595

Abdullah, N A; Wang, P N; Huang, K G; Adlan, A S; Casanova, J

2013-01-01

12

A Tenosynovial Giant Cell Tumor Arising from Femoral Attachment of the Anterior Cruciate Ligament  

PubMed Central

The localized type of tenosynovial giant cell tumor usually occurs on the palmar side of fingers and toes. Tenosynovial giant cell tumors of the tendon sheath are rarely intra-articular. We report a giant cell tumor of the tendon sheath arising from femoral attachment of the anterior cruciate ligament and its treatment with arthroscopy in a 28-year-old man. PMID:24900909

Lee, Ju-Hong

2014-01-01

13

Many postchemotherapy sarcomatous tumors in patients with testicular germ cell tumors are sarcomatoid yolk sac tumors: a study of 33 cases.  

PubMed

Sarcomatoid neoplasms in patients with testicular germ cell tumors (TGCTs) may show diverse lineages and are usually attributed to "transformation" of teratoma, although origin from yolk sac tumor (YST) has also been suggested. We evaluated 33 sarcomatoid tumors from 23 TGCT patients that lacked specific features of a defined sarcoma subtype for a number of features, including: atypia (mild, moderate, severe), cellularity, tumor necrosis, mitotic index, stromal vascularity, cell profile (spindle or epithelioid), and stromal quality (myxoid and/or fibrous). Immunohistochemical staining analyses directed against cytokeratin (AE1/AE3), SALL4, glypican-3 (GPC3), ?-fetoprotein (AFP), p63, glial fibrillary acidic protein (GFAP), CD34, MUC4, smooth muscle actin (SMA), desmin, caldesmon, and myogenin were performed. Staining intensity (0=negative, 1=weak, 2=moderate, 3=strong) and extent (0=<1%, 1=1% to 10%, 2=10% to 50%, 3=>50%) were scored. Tumor grade based on the French sarcoma grading system was assessed, with grades 2-3 considered high grade. Tumors with at least moderate intensity and >10% (+) cells for both AE1/AE3 and GPC3 were considered to be sarcomatoid YST (SYST); 22 tumors from 14 patients (ages 18 to 38 y, mean 27 y) met these criteria and were the focus of this study. All SYSTs occurred after chemotherapy (3 to 132 mo after TGCT diagnosis; mean 42.5 mo, median 30.5 mo). They had spindled (100%; 19 predominant) and epithelioid cells (77%; 3 predominant) in myxoid to fibrous stroma. Thirteen exhibited at least focally severe nuclear atypia. Distinctive tumor "ringlets" and intercellular basement membrane deposits (parietal YST differentiation) were common. In addition to positivity for AE1/AE3 and GPC3, 15/22 were SALL4 (+), 10/22 were at least focally CD34 (+), and 2/22 were focally p63 (+). Fifty percent exhibited smooth muscle differentiation as evidenced by desmin (8/19), caldesmon (2/4), and/or SMA (4/6) reactivity. AFP, MUC4, GFAP, and myogenin were negative in all cases. On follow-up, 8/14 patients died of disease at 7 to 217 months (mean 58 mo) after the initial SYST diagnosis, whereas 5/14 were alive and had no evidence of disease (ANED) at 1 to 259 months (mean 83 mo). One patient died of unrelated causes at 39 months. Of the 11 patients with high-grade tumors, 8 were dead of disease, 1 died of an unrelated cause, and 2 were ANED; all 3 patients with low-grade tumors were ANED at 41 to 262 months (mean 128 mo). We conclude that a high proportion of sarcomatoid tumors in postchemotherapy resections of TGCT patients are SYSTs. These typically occur several years after diagnosis and behave aggressively when high grade. PMID:25229769

Howitt, Brooke E; Magers, Martin J; Rice, Kevin R; Cole, Cristina D; Ulbright, Thomas M

2015-02-01

14

A bilateral primary yolk sac tumor of the lung associated with chromosome 3 polysomy  

PubMed Central

Extragonadal germ cell tumors (EGCTs) in the lung are extremely rare and their pathogenesis is poorly understood. We report a case in a 48-year-old female which was very aggressive and stained positive for primoridial germ cell markers. Interestingly, there was chromosome 3 polysomy noted. To our knowledge this is the first chromosomal aberration noted in a primary germ cell tumor of the lung. PMID:23114647

Arora, Shitij; Patel, Harish; Mir, Pervez; Mishra, Sneha; Kalra, Amita; Sawhney, Harinder; Duffoo, Frantz; Macera, Mike; Abdu, Afaf; Thelmo, William

2013-01-01

15

Primary Ewing's sarcoma family of tumors arising from the broad ligament.  

PubMed

We report a case of a primary Ewing's sarcoma family of tumors (ESFT) that was an incidental finding in the broad ligament of a 53-year-old woman. ESFT now includes tumors previously described as Askin tumor, neuroepithelioma, extraskeletal Ewing's sarcoma, and peripheral primitive neuroectodermal tumor. This is because of the discovery that all of the above tumors contain a specific gene rearrangement involving chromosome 22q12. On microscopic examination, the tumor was composed of small, round cells with mild nuclear pleomorphism and scant eosinophilic cytoplasm. There were large areas of tumor necrosis and numerous mitoses. Immunohistochemically, there was strong membrane staining for CD99 and weak focal staining for CD56 and neuron specific enolase. Fluorescence in situ hybridization revealed a separation of the breakapart probe on chromosome 22q12 consistent with the presence of a gene rearrangement, supporting the diagnosis of ESFT. We believe the importance of recognizing the existence of a primary ESFT in the broad ligament as some primary tumors of the gynecological tract and of other systems may resemble it histologically. To the best of our knowledge, our case is the second case of extraskeletal Ewings sarcoma arising from the broad ligament but the first case that is confirmed by strong CD99 positivity and supported by fluorescence in situ hybridization. PMID:16175085

Lee, Kenneth Maan Liong; Wah, Hock Kua

2005-10-01

16

Tumor like swellings arising from Hoffa's fat pad: A report of three patients  

PubMed Central

We report three rare cases of tumor-like conditions arising from Hoffa's fat pad (HFP). Patients were having persistent knee pain, the cause of which was not diagnosed by the general physician, and then were referred to us for knee pain. Magnetic resonance imaging revealed the lesions to be arising from HFP (ganglion cysts and hemangioma), as was suggested by clinical findings. Anatomy, pathology, and radiological features of the Hoffa's disease are described here to increase awareness in orthopedic community of this rare but interesting disease which is often misdiagnosed as meniscal pathology. These cases illustrate that increased cognizance can facilitate timely intervention which will prevent morbidity of the patient. PMID:22719128

Ghate, Sushant D; Deokar, Bhupal N; Samant, Ashwin V; Kale, Satish P

2012-01-01

17

Clear cell adenocarcinoma arising from abdominal wall endometriosis mimicking urachal tumor.  

PubMed

A 41-year-old woman presented with severe lower abdominal pain. She had a history of 2 cesarean deliveries. Magnetic resonance imaging (MRI) revealed a 4.3 × 4.6 × 4.8-cm mass on the urinary bladder dome. Preoperative diagnosis was invasive urachal tumor. Wide resection of the tumor was performed. The histopathological diagnosis was clear cell adenocarcinoma with endometriosis. MRI revealed normal-sized ovaries and uterus. The definite diagnosis of clear cell carcinoma arising from abdominal wall endometriosis was made. Adjuvant chemotherapy with paclitaxel and carboplatin (total 6 courses) was planned. The patient has thus far received 4 courses of this treatment. PMID:22656428

Sawazaki, Harutake; Goto, Hirofumi; Takao, Noriyasu; Taki, Yoji; Takeuchi, Hideo

2012-06-01

18

Endoscopic full-thickness resection for gastric submucosal tumors arising from the muscularis propria layer  

PubMed Central

AIM: To evaluate the efficacy, safety and feasibility of endoscopic full-thickness resection (EFR) for the treatment of gastric submucosal tumors (SMTs) arising from the muscularis propria. METHODS: A total of 35 gastric SMTs arising from the muscularis propria layer were resected by EFR between January 2010 and September 2013. EFR consists of five major steps: injecting normal saline into the submucosa; pre-cutting the mucosal and submucosal layers around the lesion; making a circumferential incision as deep as the muscularis propria around the lesion using endoscopic submucosal dissection and an incision into the serosal layer around the lesion with a Hook knife; a full-thickness resection of the tumor, including the serosal layer with a Hook or IT knife; and closing the gastric wall with metallic clips. RESULTS: Of the 35 gastric SMTs, 14 were located at the fundus, and 21 at the corpus. EFR removed all of the SMTs successfully, and the complete resection rate was 100%. The mean operation time was 90 min (60-155 min), the mean hospitalization time was 6.0 d (4-10 d), and the mean tumor size was 2.8 cm (2.0-4.5 cm). Pathological examination confirmed the presence of gastric stromal tumors in 25 patients, leiomyomas in 7 and gastric autonomous nerve tumors in 2. No gastric bleeding, peritonitis or abdominal abscess occurred after EFR. Postoperative contrast roentgenography on the third day detected no contrast extravasation into the abdominal cavity. The mean follow-up period was 6 mo, with no lesion residue or recurrence noted. CONCLUSION: EFR is efficacious, safe and minimally invasive for patients with gastric SMTs arising from the muscularis propria layer. This technique is able to resect deep gastric lesions while providing precise pathological information about the lesion. With the development of EFR, the indications of endoscopic resection might be extended. PMID:25320536

Huang, Liu-Ye; Cui, Jun; Lin, Shu-Juan; Zhang, Bo; Wu, Cheng-Rong

2014-01-01

19

Coincidence between malignant perivascular epithelioid cell tumor arising in the gastric serosa and lung adenocarcinoma.  

PubMed

A 4-mo history of both epigastralgia and back pain was presented in a 39-year-old male. Computed tomography showed right lung nodule and abdominal mass attached to the gastric wall, measuring approximately 30 mm and 70 mm in diameter. Since biopsy samples from the lung and abdomen revealed poorly differentiated adenocarcinoma and malignant tumor, clinicians first interpreted the abdominal mass as metastatic carcinoma, and a right lower lobectomy with following resection of the mass was performed. Gross examination of both lesions displayed gray-whitish to yellow-whitish cut surfaces with hemorrhagic and necrotic foci, and the mass attached to the serosa of the lesser curvature on the gastric body. On microscopic examination, the lung tumor was composed of a proliferation of highly atypical epithelial cells having abundant eosinophilic cytoplasm, predominantly arranged in an acinar or solid growth pattern with vessel permeation, while the abdominal tumor consisted of sheets or nests with markedly atypical epithelioid cells having pleomorphic nuclei and abundant eosinophilic to clear cytoplasm focally in a radial perivascular or infiltrative growth pattern. Immunohistochemically, the latter cells were positive for HMB45 or ?-smooth muscle actin, but the former ones not. Therefore, we finally made a diagnosis of malignant perivascular epithelioid cell tumor (PEComa) arising in the gastric serosa, combined with primary lung adenocarcinoma. Furthermore, small papillary carcinoma of the thyroid gland was identified. The current case describes the coincidence of malignant PEComa with other carcinomas, posing a challenge in distinction from metastatic tumor disease. PMID:25632212

Yamada, Sohsuke; Nabeshima, Atsunori; Noguchi, Hirotsugu; Nawata, Aya; Nishii, Hisae; Guo, Xin; Wang, Ke-Yong; Hisaoka, Masanori; Nakayama, Toshiyuki

2015-01-28

20

Coincidence between malignant perivascular epithelioid cell tumor arising in the gastric serosa and lung adenocarcinoma  

PubMed Central

A 4-mo history of both epigastralgia and back pain was presented in a 39-year-old male. Computed tomography showed right lung nodule and abdominal mass attached to the gastric wall, measuring approximately 30 mm and 70 mm in diameter. Since biopsy samples from the lung and abdomen revealed poorly differentiated adenocarcinoma and malignant tumor, clinicians first interpreted the abdominal mass as metastatic carcinoma, and a right lower lobectomy with following resection of the mass was performed. Gross examination of both lesions displayed gray-whitish to yellow-whitish cut surfaces with hemorrhagic and necrotic foci, and the mass attached to the serosa of the lesser curvature on the gastric body. On microscopic examination, the lung tumor was composed of a proliferation of highly atypical epithelial cells having abundant eosinophilic cytoplasm, predominantly arranged in an acinar or solid growth pattern with vessel permeation, while the abdominal tumor consisted of sheets or nests with markedly atypical epithelioid cells having pleomorphic nuclei and abundant eosinophilic to clear cytoplasm focally in a radial perivascular or infiltrative growth pattern. Immunohistochemically, the latter cells were positive for HMB45 or ?-smooth muscle actin, but the former ones not. Therefore, we finally made a diagnosis of malignant perivascular epithelioid cell tumor (PEComa) arising in the gastric serosa, combined with primary lung adenocarcinoma. Furthermore, small papillary carcinoma of the thyroid gland was identified. The current case describes the coincidence of malignant PEComa with other carcinomas, posing a challenge in distinction from metastatic tumor disease. PMID:25632212

Yamada, Sohsuke; Nabeshima, Atsunori; Noguchi, Hirotsugu; Nawata, Aya; Nishii, Hisae; Guo, Xin; Wang, Ke-Yong; Hisaoka, Masanori; Nakayama, Toshiyuki

2015-01-01

21

Occult oncocytoma of the lacrimal sac.  

PubMed

Oncocytoma of the lacrimal sac is a rarely encountered clinical entity. We report the case of a 72-year-old female patient who was diagnosed to have bilateral nasolacrimal duct obstruction during a pre-cataract surgery screening. Subsequently, she underwent bilateral dacryocystectomy. Histopathological examination of the left lacrimal sac revealed a tumour composed of acini lined by oncocytic cells; features consistent with those of a lacrimal sac oncocytoma. Although rare, oncocytomas arising from the lacrimal sac may co-exist with a nasolacrimal duct obstruction. This report describes the histological and immunochemistry characteristics of oncocytomas and underscores the need to subject all excised lacrimal sacs to histopathological examination. PMID:24526865

Mulay, Kaustubh; Nair, Akshay; Honavar, Santosh G

2014-01-01

22

Temporally separated bilateral anal sac gland carcinomas in four dogs.  

PubMed

Anal sac gland carcinoma arising from the apocrine secretory epithelium in the anal sac wall, is locally invasive and highly metastatic. The majority of anal sac gland carcinomas are unilateral on presentation, but bilateral tumours have been identified. This case series presents the outcome of four unique cases of unilateral anal sac gland carcinoma which subsequently developed contralateral anal sac gland carcinoma 50 to 390 days after removal of the initial tumour. Median survival was 1035 days after initial diagnosis and 807 days after diagnosis of the second anal sac gland carcinoma. PMID:23659267

Bowlt, K L; Friend, E J; Delisser, P; Murphy, S; Polton, G

2013-08-01

23

Androgen-Receptor Positive Lacrimal Sac Adenocarcinoma Demonstrating Long-Lasting Response to LHRH Analog Plus Abiraterone Treatment  

PubMed Central

Tumors arising at the lacrimal sac are extremely rare, as a limited number of cases have been reported worldwide. They are commonly primary and the majority of them are malignant and epithelial in origin. Adenocarcinomas account for a small percentage of these tumors. Treatment of local disease mainly includes complete surgical resection. However, metastatic disease has a poor prognosis and the development of new treatment strategies is highly important. Research efforts mainly focus on the identification of molecular targets for therapy. Herein, we describe for the first time a case of a patient with an androgen receptor expressing adenocarcinoma of the lacrimal sac that had an impressive response to abiraterone.

Vagia, Elena; Economopoulou, Panagiota; Oikonomopoulos, Nikolaos; Athanasiadis, Ilias; Dimitriadis, George; Psyrri, Amanda

2015-01-01

24

A Pancreatic Head Tumor Arising as a Duodenal GIST: A Case Report and Review of the Literature.  

PubMed

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the gastrointestinal tract that originate from the intestinal cells of Cajal (ICC) (Fletcher et al., 2002). Only a few cases have been described with extragastrointestinal stromal tumors (Kim et al., 2012; Soufi et al., 2013; Meng et al., 2011). They are often diagnosed as a pancreatic head tumor as they are very difficult to relate to the duodenum with CT, MRI, or ultrasound. We present a case of a sixty-four-year-old woman who presented with abdominal pain and cardialgia for a follow-up examination after breast cancer surgery. On laparotomy there was a 3?×?5?cm hypervascular mass arising from the pancreatic head with macroscopically no attachment to the duodenum. The patient underwent pancreatoduodenectomy (PD) modified after Traverso-Longmire, histopathology proved a duodenal GIST. This case proves that duodenal GISTs can grow invasively into the pancreas and appear as solid pancreas head tumor; therefore, these tumors should be included into differential diagnosis. PMID:25295063

Bormann, Fabian; Wild, Wolfgang; Aksoy, Hüseyin; Dörr, Pius; Schmeck, Sanja; Schwarzbach, Matthias

2014-01-01

25

A Pancreatic Head Tumor Arising as a Duodenal GIST: A Case Report and Review of the Literature  

PubMed Central

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the gastrointestinal tract that originate from the intestinal cells of Cajal (ICC) (Fletcher et al., 2002). Only a few cases have been described with extragastrointestinal stromal tumors (Kim et al., 2012; Soufi et al., 2013; Meng et al., 2011). They are often diagnosed as a pancreatic head tumor as they are very difficult to relate to the duodenum with CT, MRI, or ultrasound. We present a case of a sixty-four-year-old woman who presented with abdominal pain and cardialgia for a follow-up examination after breast cancer surgery. On laparotomy there was a 3?×?5?cm hypervascular mass arising from the pancreatic head with macroscopically no attachment to the duodenum. The patient underwent pancreatoduodenectomy (PD) modified after Traverso-Longmire, histopathology proved a duodenal GIST. This case proves that duodenal GISTs can grow invasively into the pancreas and appear as solid pancreas head tumor; therefore, these tumors should be included into differential diagnosis. PMID:25295063

Bormann, Fabian; Wild, Wolfgang; Aksoy, Hüseyin; Dörr, Pius; Schmeck, Sanja; Schwarzbach, Matthias

2014-01-01

26

[Case report: Tenosynovial giant cell tumor arising from the knee joint].  

PubMed

Giant cell tumor of the tendon sheath and synovium or pigmented villonodular synovitis of the tendon is a benign neoplasm, although there are rarely reported malignant metastatic forms. The most common location is the hand. Large joints such as the ankle and knee are infrequently affected. Diagnosis might be suspected radiologically, but the exact diagnosis has to be confirmed by histopathologic examination. In this study, we report MRI findings of three giant cell tumors of the tendon sheath. PMID:14661299

Yildiz, Sevim; Cetinkol, Erkin

2003-03-01

27

CASE REPORT: Adenocarcinoma Within a Diverticulum: A Common Tumor Arising in an Uncommon Location  

Microsoft Academic Search

Colon cancer and diverticulitis occasionally coexist. A variety of studies have been conducted to determine if this relationship is random or significant. We report a rare case of an adeoncarcinoma arising within a single sigmoid diverticulum forming a fistula connection with the bladder. CASE REPORT A 63-year-old man presented with burning, and the passage of flatus with urination. A cystoscopic

Charles F. Bellows; Salima Haque

2002-01-01

28

Two Cases of Glomus Tumor Arising in Large Airway: Well Organized Radiologic, Macroscopic and Microscopic Findings  

PubMed Central

Glomus tumors of the lung are rare benign neoplasm, originating from modified smooth muscle cells. The patients are usually presented with no or non-specific symptoms such as cough, dyspnea or hemoptysis. Although surgical treatment is considered as the treatment of choice, the endobronchial therapy can be applied to the patients who are unfit for surgical excision. Herein, we describe two rare cases of glomus tumor originated at large airway (trachea and main bronchus) without respiratory symptoms and review their characteristic radiologic, macroscopic and pathological features. PMID:24523816

Choi, In Ho; Song, Dae Hyun; Kim, Jhingook

2014-01-01

29

TERATOMA WITH MALIGNANT TRANSFORMATION: DIVERSE MALIGNANT HISTOLOGIES ARISING IN MEN WITH GERM CELL TUMORS  

Microsoft Academic Search

PurposeTeratoma with malignant transformation refers to a form of germ cell tumor in which a somatic teratomatous component becomes morphologically malignant and develops aggressive growth. We evaluated the spectrum of histologies, chromosomal abnormalities and clinical outcome in patients with teratoma with malignant transformation.

Robert J. Motzer; Alison Amsterdam; Victor Prieto; Joel Sheinfeld; V. V. V. S. Murty; Madhu Mazumdar; George J. Bosl; R. S. K. Chaganti; Victor E. Reuter

1998-01-01

30

Hypercalcemia Associated with a Malignant Brenner Tumor Arising from a Mature Cystic Teratoma  

PubMed Central

A 60-year-old woman presented with abdominal pain and weight loss and was found to have serum calcium of 15.0 mg/dl. Serum parathyroid hormone-related peptide (PTHrP) returned elevated. Imaging suggested bilateral mature cystic teratomas. Her hypercalcemia was treated initially with intravenous saline, as well as intramuscular and subcutaneous calcitonin. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, and final pathology revealed malignant Brenner tumor in association with a mature cystic teratoma. Her postoperative PTHrP returned less than assay, and her total and ionized calcium fell below normal, requiring supplemental calcium and vitamin D. At follow-up one month after discharge, her calcium had normalized. We present the first reported case of hypercalcemia occurring in association with a malignant Brenner tumor. Malignancy-associated hypercalcemia occurs via four principal mechanisms: (1) tumor production of PTHrP; (2) osteolytic bone involvement by primary tumor or metastasis; (3) ectopic activation of vitamin D to 1,25-(OH)2 vitamin D, and (4) ectopic production of parathyroid hormone. PTHrP-mediated hypercalcemia is the most common mechanism and was responsible in this case. In patients with paraneoplastic hypercalcemia who undergo surgical treatment, close monitoring and management of serum calcium is necessary both pre- and postoperatively. PMID:23185165

Honigberg, Michael C.; Bradford, Leslie S.; Prabhakar, Anand M.; Hariri, Lida P.; Goodman, Annekathryn

2012-01-01

31

Concurrent Malignant Solitary Fibrous Tumor Arising from the Omentum and Grade 3 Endometrial Endometrioid Adenocarcinoma of the Uterus with p53 Immunoreactivity  

PubMed Central

A malignant solitary fibrous tumor arising from the omentum is extremely rare. To our knowledge, this is the first case of a malignant solitary fibrous omentum tumor coexisting with uterine corpus cancer. A 62-year-old woman presented to our hospital with vaginal discharge. Endometrioid adenocarcinoma was diagnosed by endometrial curettage. In addition, a solid tumor in front of the uterus was detected following computed tomography and/or magnetic resonance imaging, which was suspected to be a primary (or secondary) malignant tumor arising from the omentum. Hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and lymphadenectomy were performed. A malignant solitary fibrous tumor of the omentum and grade 3 endometrioid adenocarcinoma of the uterus were diagnosed by pathohistological analysis. Interestingly, the tumor cells were immunoreactive for p53. Adjuvant chemotherapy was administered for the uterine corpus cancer and the patient remains healthy 48 months after the surgery. These tumors may have become malignant due to the presence of p53 mutations. PMID:25114818

Nobuhara, Ichiro; Haruta, Noriko; Higashiura, Yumi; Watanabe, Hideki; Ohno, Sumire

2014-01-01

32

A Rare Case of Endolymphatic Sac Tumour: Clinicopathologic Study and Surgical Management  

PubMed Central

Objective. Endolymphatic sac tumor (ELST) is a rare neoplasm arising from the intrapetrous portion of the endolymphatic sac, either isolated or in association with the von Hippel-Lindau disease. We report a sporadic case of ELST with an overview of the literature and a discussion of clinic-radiological, histopathologic, and surgical findings. Case Report. A young woman presented with a progressive hearing loss in the left ear. Otoscopy showed a reddish, bleeding hypotympanic mass. CT demonstrated an expansile lytic mastoid lesion extending to the middle ear, with bone erosion. MRI confirmed a lesion of increased signal on T1-weighted sequences. The patient underwent a canal wall-down tympanoplasty with complete removal of the tumor. Histopathology was consistent with a papillary ELST. Immunohistochemistry was positive for cytokeratin and chromogranin A. Conclusion. This paper highlights the rarity of ELST, the need for an accurate neuroradiological and immunohistochemical study at the early stages, and the timeliness of surgical treatment. PMID:24991442

Ferri, Emanuele; Amadori, Maurizio; Armato, Enrico; Pavon, Ida

2014-01-01

33

Information Cul de Sac  

E-print Network

Korea has a "comprehensive official fantasy worldview" which even the smallest of outside information leaks could easily destroy. And so, instead of the information superhighway, North Korea has the information cul de sac. #ceas #hacker #North...

Hacker, Randi; Tsutsui, William

2007-01-10

34

Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors  

ClinicalTrials.gov

Childhood Extracranial Germ Cell Tumor; Childhood Extragonadal Germ Cell Tumor; Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Yolk Sac Tumor; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Ovarian Germ Cell Tumor; Testicular Choriocarcinoma; Testicular Choriocarcinoma and Embryonal Carcinoma; Testicular Choriocarcinoma and Yolk Sac Tumor; Testicular Embryonal Carcinoma; Testicular Embryonal Carcinoma and Yolk Sac Tumor; Testicular Yolk Sac Tumor

2014-03-18

35

Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization.  

PubMed

Carcinoma arising from Warthin tumor is extremely rare. A 79-year-old man was admitted for a firm, well-defined, 5-cm left infra-auricular mass. Aspiration cytology showed many lymphohistiocytes and oncocytes in a proteinaceous background, compatible with Warthin tumor. A left superficial parotidectomy showed a solid mass around the cyst wall. The tumor cells of the solid area were arranged as infiltrative ducts with a few foci of malignant transformation. Virtual karyotyping disclosed a complex pattern of genetic aberrations with a focal amplification in 12q14-q21.2. This chromosomal region contains the MDM2 (murine double minute) gene, which regulates p53 inactivation. HER2 fluorescence in situ hybridization showed a focal amplification. Subsequently, the patient underwent total parotidectomy and ipsilateral neck dissection for a recurrence. To our knowledge, this is the first case of salivary duct carcinoma arising from Warthin tumor. The essential molecular pathway has not been reported, we presume an important role of MDM2 amplification- P53 inactivation. PMID:21877991

Kim, Hyun-Jung; Yoo, Young Sam; Park, Kyeongmee; Kwon, Ji-Eun; Kim, Jung Yeon; Monzon, Federico A

2011-09-01

36

Exceptionally large solitary fibrous tumor arising from the cheek: an immunohistochemical and ultrastructural study with a review of the literature.  

PubMed

Solitary fibrous tumor (SFT) is a rare mass-forming soft tissue tumor that occurs most commonly in the pleura, but has been described in various extrathoracic sites. Extrapleural manifestation of SFT, particularly in the head and neck region, is rare. The most common extrapleural site is the oral cavity; these tumors have also been described in the orbit, nasopharynx, paranasal sinuses, salivary glands, and larynx. We report an extremely rare case of a SFT in the subcutaneous region of the cheek. This tumor in the left cheek was a large firm mass, approximately 8.5 cm × 6 cm in size and was successfully treated by surgical resection. Immunohistochemistry revealed reactivity for vimentin, CD34, and bcl-2, but no staining for cytokeratin, epithelial membrane antigen, S-100, desmin, caldesmon, actin, ?-smooth muscle actin, CD117, and CD99. Immunohistochemical study is the key to establish a definitive diagnosis of SFT, and ultrastructural study is also useful for making an accurate diagnosis. The patient recovered uneventfully without evidence of tumor recurrence 2 years after surgery. PMID:24221815

Satomi, Takafumi; Hasegawa, On; Abukawa, Harutsugu; Kohno, Michihide; Enomoto, Ai; Chikazu, Daichi; Matsubayashi, Jun; Nagao, Toshitaka

2014-06-01

37

Keratocystic odontogenic tumor arising at the mandibular ramus with an impacted tooth: a case report and mimic lesions.  

PubMed

Objectives: To consider the biologic behaviors of keratocystic odontogenic tumors (KCOTs) and ameloblastomas and dentigerous cysts. Methods: A 63-year-old Japanese man presented with swelling and discomfort in the left cheek during jaw movement. Examination revealed a multilocular lesion within the mandible extending from the left second premolar to the left mandibular ramus and coronoid process; the lesion contained a deviated impacted tooth. The tumor had expanded beyond the bone and was invading the masseter and medial pterygoid muscles. Marginal mandibulectomy with a free iliac bone graft was performed. Results: No recurrence was observed during a 7-year follow-up. Discussion: The histopathological diagnosis of the lesion showed it was a KCOT. These tumors usually grow within the bone, causing bone expansion. However, this tumor had expanded beyond the bone and invaded surrounding muscles. Thus, KCOTs can, in rare cases, manifest themselves as described here. Evaluating preoperative images and histopathological findings is important to determine the optimal treatment strategy. PMID:25371100

Kimura, Takashi; Ohba, Seigo; Yoshimura, Hitoshi; Fujita, Shuichi; Imamura, Yoshiaki; Kitagawa, Yoshimasa; Sano, Kazuo

2014-11-01

38

Solitary fibrous tumor arising from the mesentery of adult patients. Report of two cases and review of the literature.  

PubMed

Solitary fibrous tumors (SFTs) represent an uncommon entity most frequently manifested in the pleura. We describe herein two new cases located in the jejunal and sigmoid mesentery incidentally found in patients aged 61 and 32 years. In a review of the literature, we have compiled 15 mesenteric SFTs including our two cases. The mean age of the patients at presentation was 51.7 years (range, 26-83 years). Most patients were males (males:females 4:1). Although occasionally these tumors were an incidental finding, the majority have been symptomatic. Tumors varied greatly in size (3 to 25 cm), but most of them were large (mean 14.8 cm). Most cases (60%) were located in the small intestine mesentery. The hemangiopericytomatous (cellular) variant was the most common. All patients were treated by surgery and no other therapeutic approaches (chemo-/radiotherapy) were used. Follow-up data were available in 11 cases and ranged from six days to 21 years, with a mean follow-up period of 36.2 months. None recurred or metastasized. Two (13.3%) of the 15 cases showed atypical histological features concordant with histological, but not clinical malignancy. The main differential diagnosis includes gastrointestinal stromal tumor, synovial sarcoma and reactive nodular fibrous pseudotumor of the mesentery. In one third of the cases, tumor excision did not require intestinal resection. To our knowledge, our Case No. 1 is the first reported that has been removed through laparoscopic surgery. Radical surgery remains the treatment of choice. The unpredictable behavior of SFTs requires a careful, close, long-term follow-up. PMID:24715189

Val-Bernal, José Fernando; Mayorga, Marta; Fernández, Fidel; Parra, Alejandro; Crespo, Juan; García-Polavieja, Manuel

2014-01-01

39

Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke–Löwenstein tumor): a case report and review of the literature  

PubMed Central

Introduction Verrucous carcinoma of the external genitalia and perianal region is a rare variant of well-differentiated squamous cell carcinoma. It has been reported to have limited metastatic potential. Case presentation We report the case of a 54 year-old Moroccan man who presented with locally advanced giant condyloma acuminatum (Buschke–Löwenstein tumor) after prolonged intervals of neglect (approximately 10 years). The disease covered his suprapubic, external genitalia and perianal region. It was locally aggressive with extensive tissue destruction. After a biopsy of the lesion, the diagnosis of verrucous carcinoma was confirmed. He initially received chemoradiotherapy, followed by extensive local excision, but he developed septic shock and died a few days later. Conclusions The purpose of this case report is to present a case of verrucous carcinoma arising in an extensive giant condyloma acuminatum (Buschke–Löwenstein tumor) and discuss the literature on its diagnosis and management. PMID:24354693

2013-01-01

40

EBV-Associated Smooth Muscle Neoplasms: Solid Tumors Arising in the Presence of Immunosuppression and Autoimmune Diseases  

PubMed Central

Background. Epstein-Barr virus (EBV)-related smooth muscle neoplasms (SMNs) have been associated with immune dysregulation, most notably in patients who have undergone solid organ transplantation or in patients with HIV/AIDS. Objective. to report our experience with EBV-related neoplasms as well as describing the first EBV-related SMN in the setting of administration of glucocorticoids and the tumor necrosis factor inhibitor etanercept. Design. We have case reports, of minimum 3-year follow-up, 2002–2005. Setting. It was held in an academic and tertiary referral cancer center. Patients. Patients are with dysregulated immunity after solid organ transplantation, HIV/AIDS, or with psoriasis after treatment with etanercept. Interventions. There were discontinuation of etanercept, right hepatic trisegmentectomy, and chemotherapy. Measurements. We use survival as a measurement here. Results. Patients who were able to withstand reduction in immunosuppression survived. Surgical resection or chemotherapy was successful in delaying progression of disease. Limitations. There was a relatively short follow-up for these slow-growing neoplasms. Conclusion. EBV-related SMNs have variable aggressiveness. While chemotherapy may slow disease progression, resection and improving the host immune status provide the best opportunity for primary tumor control. PMID:19079588

Moore Dalal, Kimberly; Antonescu, Cristina R.; DeMatteo, Ronald P.; Maki, Robert G.

2008-01-01

41

Sinonasal teratocarcinosarcoma with yolk sac elements: a neoplasm of somatic or germ cell origin?  

PubMed

Sinonasal teratocarcinosarcoma is an uncommon, aggressive, morphologically heterogenous tumor composed of cells derived from the 3 somatic layers. A histogenetic origin from a multipotential adult somatic stem cell with divergent differentiation has been favored over a germ cell origin. This assumption has been based on the lack of germ cell elements and, until recently, the absence of demonstrable amplification of 12p. We report a case that exhibited foci of yolk sac elements with papillary structures and intracytoplasmic periodic acid-Schiff-positive, diastase-resistant, ?-fetoprotein-positive, hyaline globules. An expanded area of undifferentiated cells, likely precursor cells, in the basal layer of the overlying mucosal epithelium transitions into and merges with the immature epithelial, neuroepithelial, and mesenchymal components. These previously unreported histomorphological features support the hypothesis that this tumor is a teratomatous tumor arising from pluripotent embryonic stem cells in the basal layer of the sinonasal epithelium. That notion is further supported by fluorescence in situ hybridization cytogenetic analysis, which showed a distinct subpopulation of the tumor cells with an extra copy of chromosome 12p13. PMID:20952296

Thomas, Jaiyeola; Adegboyega, Patrick; Iloabachie, Kenny; Mooring, John Wesley; Lian, Timothy

2011-04-01

42

Cul-de-Sac Kids  

ERIC Educational Resources Information Center

Previous research indicates that adults who live on cul-de-sac streets are more likely to have positive experiences with neighbors than residents of other street types (Brown and Werner, 1985; Hochschild Jr, 2011; Mayo Jr, 1979; Willmott, 1963). The present research ascertains whether street design has an impact on children's neighborhood…

Hochschild, Thomas R., Jr.

2013-01-01

43

Well-differentiated papillary mesothelioma manifesting in a hernia sac.  

PubMed

Well-differentiated papillary mesothelioma (WDPM) is a tumor of uncertain malignant potential that usually occurs as a multifocal lesion of the female peritoneum, and is incidentally found at the time of surgery. We present here a multifocal case that had arisen from the lining of a hernia sac. To our knowledge, only four cases of this event have been previously described. A review of the five cases reported, including our case, revealed that the mean age of the patients was 56.6±8.35 years. There was predominance in men (4:1). In four cases, the lesion was incidental. Most tumors were found in inguinal hernias. Four cases presented with gross abnormalities in the hernia sac. All the five patients were alive with no evidence of WDPM after a mean follow-up of 38.6 months. Extensive sampling of this rare lesion helps to rule out an epithelial malignant mesothelioma and prevents overtreatment. PMID:24860916

Val-Bernal, José Fernando; Mayorga, Marta; Val, Daniel; Garijo, María Francisca

2014-09-01

44

Performance Analysis of Wavelength Multiplexed Sac Ocdma Codes in Beat Noise Mitigation in Sac Ocdma Systems  

NASA Astrophysics Data System (ADS)

In this paper we investigate the use of wavelength multiplexed spectral amplitude coding (WM SAC) codes in beat noise mitigation in coherent source SAC OCDMA systems. A WM SAC code is a low weight SAC code, where the whole code structure is repeated diagonally (once or more) in the wavelength domain to achieve the same cardinality as a higher weight SAC code. Results show that for highly populated networks, the WM SAC codes provide better performance than SAC codes. However, for small number of active users the situation is reversed. Apart from their promising improvement in performance, these codes are more flexible and impose less complexity on the system design than their SAC counterparts.

Alhassan, A. M.; Badruddin, N.; Saad, N. M.; Aljunid, S. A.

2013-07-01

45

Metastatic Cerebellar Gastrointestinal Stromal Tumor with Obstructive Hydrocephalus Arising from the Small Intestine: A Case Report and Review of the Literature  

PubMed Central

Gastrointestinal stromal tumor (GIST) is defined as a c-kit-positive gastrointestinal, mesenteric, or omental mesenchymal tumor that very rarely metastasizes to the brain. Metastasis to the cerebellum is particularly rare. An 80-year-old man presented with nausea and vomiting with disturbance of consciousness. Magnetic resonance imaging (MRI) revealed tumor in the cerebellar vermis causing obstructive hydrocephalus. The patient subsequently underwent midline suboccipital craniotomy, and the tumor was totally removed. Immunohistochemical analysis showed tumor cells positive for c-kit and CD34, and cerebellar metastasis of GIST was diagnosed. Postoperative radiotherapy was administered. Following surgery and radiotherapy, the patient developed ileus caused by tumor in the small intestine and underwent laparotomy for tumor removal. Following abdominal surgery, left hemiparesis and consciousness disturbance were noted. Computed tomography showed recurrent large tumor with perifocal edema in the right frontal lobe of the brain. The patient died 3 months after initial craniotomy. Intracranial metastasis of GIST is extremely rare. In cases such as the present, where the condition of the patient rapidly deteriorates and features such as rising intracranial pressure and ileus prevent the use of oral agents, molecular-targeted agents administered by intravenous infusion should be utilized.

Sato, Kunitomo; Kato, Naoki; Ishii, Takuya; Terao, Toru; Murayama, Yuichi

2014-01-01

46

Primary ductal adenocarcinoma of the lacrimal sac: the first reported case  

PubMed Central

Primary lacrimal sac tumor is extremely rare, and moreover, glandular tumor is exceptional. Herein, we described the first documented case of primary ductal adenocarcinoma of the lacrimal sac. A 79-year-old Japanese female presented with persistent swelling of her left lower eyelid. Computed tomography demonstrated an irregular-shaped tumor involving the left lacrimal sac, lower eyelid, sinonasal tract, and internal side of the left orbit. Biopsy from the eyelid revealed a poorly differentiated adenocarcinoma. Histopathological study of the resected lacrimal sac tumor revealed an infiltrative neoplastic growth that was composed of cribriform structures with comedonecrosis. The neoplastic cells had relatively rich granular eosinophilic cytoplasm and large round to oval nuclei containing conspicuous nucleoli. The left cervical lymph nodes had metastatic carcinoma. Immunohistochemically, the neoplastic cells were diffusely positive for gross cystic disease fluid protein-15 and androgen receptor. Moreover, mammalian target of rapamycin (mTOR), 4E-BP1, and p4E-BP1 were expressed. According to these results, an ultimate diagnosis of primary ductal adenocarcinoma of the lacrimal sac was made. Only 9 cases of primary lacrimal sac adenocarcinoma have been reported, and this is the first reported case of ductal adenocarcinoma of the lacrimal sac. Ductal adenocarcinoma of the salivary gland shows an aggressive clinical course, and the present case had multiple cervical lymph node metastases. This report is the first to demonstrate that mTOR pathway proteins, which are central proteins involved in carcinogenesis, are activated in ductal adenocarcinoma. Therefore, mTOR inhibitor may be a potential candidate for treatment of this highly aggressive carcinoma. PMID:24040460

Ishida, Mitsuaki; Iwai, Muneo; Yoshida, Keiko; Kagotani, Akiko; Kohzaki, Hideaki; Arikata, Masahiko; Shimizu, Takeshi; Okabe, Hidetoshi

2013-01-01

47

Sisters of the sinuses: cetacean air sacs.  

PubMed

This overview assesses some distinguishing features of the cetacean (whale, dolphin, porpoise) air sac system that may relate to the anatomy and function of the paranasal sinuses in terrestrial mammals. The cetacean respiratory tract has been modified through evolution to accommodate living in water. Lack of paranasal sinuses in modern cetaceans may be a diving adaptation. Bone-enclosed air chambers are detrimental, as their rigid walls may fracture during descent/ascent due to contracting/re-expanding air volumes. Flexible-walled "sinuses" (extracranial diverticula) are a logical adaptation to diving. Odontocetes (toothed whales) exhibit several pairs of paranasal air sacs. Although fossil evidence indicates that paranasal sinuses occur in archaeocetes (ancestors/relatives of living cetaceans), it is not known whether the paranasal sacs derive from these sinuses. Sac pigmentation indicates that they derived from invaginations of the integument. Unlike sinuses, paranasal sacs are not circumferentially enclosed in bone, and therefore can accommodate air volume changes that accompany diving pressure changes. Paired pterygoid sacs, located ventrally along the cetacean skull, connect the pharynx and middle ear cavities. Mysticetes (baleen whales) have a large midline laryngeal sac. Although cetacean air sacs do not appear to be homologous to paranasal sinuses, they may serve some analogous respiratory, vocal, or structural functions. For example, these sacs may participate in gas exchange, thermoregulation, resonance, and skeletal pneumatization. In addition, they may subserve unique aquatic functions, such as increasing inspiratory volume, mitigating pressure-induced volume change, air shunting to reduce respiratory dead space, and facilitating underwater sound production and transmission. PMID:18951477

Reidenberg, Joy S; Laitman, Jeffrey T

2008-11-01

48

Morphological, Histochemical, Immunohistochemical, and Ultrastructural Characterization of Tumors and Dysplastic and Non-Neoplastic Lesions Arising in BK Virus/tat Transgenic Mice  

PubMed Central

To study the role in AIDS pathogenesis of the human immunodeficiency virus type 1 (HIV-1) Tat protein, a transactivator of viral and cellular genes, we generated transgenic mice with a recombinant DNA containing BK virus (BKV) early region and the HIV-1 tat gene, directed by its own promoter-enhancer. DNA hybridization revealed that the transgene is stably maintained in all organs of transgenic mice as a tandem insertion in a number of copies ranging from 5 to 20 per cell. In addition, tat and BKV RNA were expressed in all tissues. Transgenic mice developed three types of lesions: 1) tumors, 2) hyperplastic and dysplastic lesions, and 3) non-neoplastic lesions. Tumors of different histotypes, such as lymphomas, adenocarcinomas of skin glands, leiomyosarcomas, skin squamous cell carcinomas, hepatomas, hepatocarcinomas, and cavernous liver hemangiomas, developed in 29% of transgenic animals. The majority of tumors were malignant, invasive, and producing metastases. Conversely, tumors of only two histotypes (lymphomas and adenocarcinomas of skin glands) appeared in control mice. Hyperplastic and dysplastic lesions were more frequent in transgenic than in control mice and involved the skin or its adnexes, the liver and the rectum, indicating multiple targets for the activity of the transgene. Pyelonephritis, frequently complicated with hydronephrosis, inflammatory eye lesions, and amyloid depositions represented the most frequent non-neoplastic lesions detected in transgenic mice. Many of the pathological findings observed in this animal model are comparable to similar lesions appearing in AIDS patients, suggesting a relevant role for Tat in the pathogenesis of such lesions during the course of AIDS. PMID:10233861

Altavilla, Giuseppe; Trabanelli, Cecilia; Merlin, Michela; Caputo, Antonella; Lanfredi, Massimo; Barbanti-Brodano, Giuseppe; Corallini, Alfredo

1999-01-01

49

SAC Minutes Wednesday, Nov 14, 2012  

E-print Network

the booking of the Norm on Monday, Jan 21 from 5pm - midnight by Association of Latin American Students and they will have photography there." ...Tabled OTHER BUSINESS FOLLOW-UP Philip to get in touch with Alishia on SAC

Pulfrey, David L.

50

Oncocytic adenocarcinoma of the lacrimal sac.  

PubMed

A well-differentiated, oncocytic adenocarcinoma of the lacrimal sac recurred locally in a patient during a period of 13 years. This appears to be the second documented instance of such a neoplasm. PMID:629677

Peretz, W L; Ettinghausen, S E; Gray, G F

1978-02-01

51

Waterside Stress Assisted Corrosion (SAC) of Boiler Tubes  

E-print Network

Waterside Stress Assisted Corrosion (SAC) of Boiler Tubes School of Materials Science Boiler Areas Susceptible to SAC · Generally SAC initiates near weld joints on cold side of tubes · SAC cracks are difficult to detect inaccessibility · Failures Detected at Various Locations in Boilers

Das, Suman

52

Systemic Par-4 inhibits non-autochthonous tumor growth  

PubMed Central

The tumor suppressor protein Par-4 (prostate apoptosis response-4) is spontaneously secreted by normal and cancer cells. Extracellular Par-4 induces caspase-dependent apoptosis in cancer cell cultures by binding, via its effector SAC domain, to cell surface GRP78 receptor. However, the functional significance of extracellular Par-4/SAC has not been validated in animal models. We show that Par-4/SAC-transgenic mice express systemic Par-4/SAC protein and are resistant to the growth of non-autochthonous tumors. Consistently, secretory Par-4/SAC pro-apoptotic activity can be transferred from these cancer-resistant transgenic mice to cancer-susceptible mice by bone marrow transplantation. Moreover, intravenous injection of recombinant Par-4 or SAC protein inhibits metastasis of cancer cells. Collectively, our findings indicate that extracellular Par-4/SAC is systemically functional in inhibition of tumor growth and metastasis progression, and may merit investigation as a therapy. PMID:21613819

Brandon, Jason; Qiu, Shirley; Shelton, Brent J; Spear, Brett; Bondada, Subbarao; Bryson, Scott

2011-01-01

53

SAC-B, Argentine scientific satellite  

NASA Technical Reports Server (NTRS)

The project and the missions of the Argentine scientific satellite, SAC-B, are summarized. SAC-B is an international cooperative project between NASA and the Secretariat of State of Science and Technology of the Argentine Republic. The objective of SAC-B is to advance the study of solar physics and astrophysics through the examination of solar flares, gamma ray burst sources and the diffuse soft X-ray cosmic background. The scientific payload comprises an instrument to measure the temporal evolution of X-ray emissions from solar flares as well as nonsolar gamma ray bursts, a combined soft X-ray and gamma ray burst detector, a diffuse X-ray background detector, and an energetic neutral atoms detector.

Gulich, J. M.; White, C.

1994-01-01

54

13. SAC command center, weather center, underground structure, building 501, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. SAC command center, weather center, underground structure, building 501, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

55

68. Aerial view of SAC command post, building 500, looking ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

68. Aerial view of SAC command post, building 500, looking northeast, spring, 1957 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

56

SAC Minutes Thursday, July 26, 2012  

E-print Network

. INTRODUCTIONS The chair was passed to Adam Melhem at 4:31pm. 2. PRESENTATIONS The Knitting and Sewing Club CLARKE MCCORKELL: "BE IT RESOLVED THAT SAC approve the constitution of Knitting and Sewing Club as an AMS club." *started as social knitting group in Totem last year. ...Carried MOVED ADAM MELHEM, SECONDED

Pulfrey, David L.

57

SAC Tax Help Prepared Feb. 2010  

E-print Network

1 SAC Tax Help Prepared Feb. 2010 Disclaimer: We are not tax experts, and cannot be held responsible for your tax forms. (neither can DBBS, WashU, etc...) 1 Taxes for international students Go to http://oisshome.wustl.edu/taxes/FilingTaxes.html for tax information from the Office for International

Doering, Tamara

58

SAC Minutes Wednesday, Oct 24, 2012  

E-print Network

SAC Minutes Wednesday, Oct 24, 2012 SUB ROOM 266J, 3:00pm Attendance: Adam Melhem, Alishia Adam, Caroline Wong, Elaine Kuo, Clarke Mccorkell, Kathleen Handfield, Barnabas Caro, Philip He, Jeffrey Smith with athletics Adam and Nicola to follow up with club regarding finances 3. MOVED ALISHIA ADAM, SECONDED PHILIP

Pulfrey, David L.

59

SAC Minutes Thursday, January 12, 2012  

E-print Network

SAC Minutes Thursday, January 12, 2012 SUB ROOM 266J, 5:00 pm Attendance: Elaine Kuo, Audrey, 2011." ...Carried The chair was passed to AUDREY GARDINER. 5. BOOKINGS The chair was passed to AUDREY stay overnight in the SUB? Please see the attached email for more info. ...Carried MOVED AUDREY

Pulfrey, David L.

60

Adult alveolar rhabdomyosarcoma of the lacrimal sac.  

PubMed

Lacrimal sac tumours are rare, but must be considered in the diagnosis of patients presenting with masses in the medial canthal region. We report a single case of lacrimal sac rhabdomyosarcoma in a 31-year-old man. The patient self-presented to the eye department with a 4-week history of discomfort, epiphora and a medial canthal mass. After no response to 1 week of oral antibiotics for a presumed diagnosis of dacryocystitis and the presence of firm mass extending above the medial canthal tendon, surgical exploration was carried out which revealed a lacrimal sac mass. Histologically this showed an alveolar rhabdomyosarcoma, which was confirmed on immunohistochemistry. After 4 rounds of chemotherapy and 50.4Gy of radical radiotherapy, the patient is well with no signs of further local or distant disease at 11-months follow-up and 20 months following initial diagnosis. To our knowledge, there are no previously reported adult cases of lacrimal sac alveolar rhabdomyosarcoma in the peer-reviewed literature. We want to highlight the unique diagnosis in this case as well as drawing attention to the possibility of malignancy in patients responding poorly to management when an initial diagnosis of dacryocystitis is made in the presence of a medial canthal mass. PMID:25207922

Neffendorf, James E; Bagdonaite, Laura; Mudhar, Hardeep S; Pearson, Andrew R

2014-12-01

61

Hernia sacs: is histological examination necessary?  

PubMed

The hernia sac is a common surgical pathology specimen which can occasionally yield unexpected diagnoses. The College of American Pathologists recommends microscopic examination of abdominal hernias, but leaves submission of inguinal hernias for histology to the discretion of the pathologist. To validate this approach at a tertiary care centre, we retrospectively reviewed 1426 hernia sacs derived from inguinal, femoral and abdominal wall hernias. The majority of pathologies noted were known to the clinician, including herniated bowel, lipomas and omentum. A malignancy was noted in three of 800 inguinal hernias and seven of 576 abdominal wall hernias; five of these lesions were not seen on gross examination. Other interesting findings in hernia sacs included appendices, endometriosis, a perivascular epithelioid cell tumour, and pseudomyxoma peritoneii. All hernia sacs should be examined grossly as most pathologies are grossly visible. The decision to submit inguinal hernias for histology may be left to the discretion of the pathologist, but abdominal and femoral hernias should be submitted for histology. PMID:23794497

Wang, Tao; Vajpeyi, Rajkumar

2013-12-01

62

UNIVERSITY SECRETARIAT How to Appeal to SAC  

E-print Network

1 UNIVERSITY SECRETARIAT STUDENT APPEALS How to Appeal to SAC #12;2 ACADEMIC APPEALS INFORMATION who are considering appealing a petition, reappraisal or academic honesty decision to the Senate Appeals Committee from their Faculty Council. It is intended to answer general questions that students may

63

Sunitinib in Treating Young Patients With Refractory Solid Tumors  

ClinicalTrials.gov

Central Nervous System Metastases; Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Recurrent Childhood Central Nervous System Embryonal Tumor; Unspecified Childhood Solid Tumor, Protocol Specific

2014-01-27

64

Aquarius/SAC-D Educational Wall Poster  

NSDL National Science Digital Library

This is a poster about the Aquarius/SAC-D satellite mission, with an image depicting the satellite in orbit. The back of the poster describes the mission's scientific goals and benefits, including the scientific value of maps of sea surface salinity. The Hands On Activities & Online Data Tools panel gives an overview of the classroom lessons and tools that are available on the mission website.

65

Cecal bascule herniation into the lesser sac  

PubMed Central

Cecal bascule is a rare cause of bowel obstruction in which a mobile cecum folds anteriorly and superiorly over the ascending colon. Herein, we present the first case of internal herniation of a cecal bascule into the lesser sac through the foramen of winslow, aiming at discussing radiological findings, differential diagnosis, and surgical management of this uncommon condition. A 75-year-old female presented to the emergency room with an 18-h history of sudden onset sharp, progressively worsening abdominal pain associated with vomiting. Physical exam revealed abdominal distention and epigastric tenderness while initial laboratory tests were unremarkable. Computed tomography of her abdomen and pelvis showed a loop of distended colon within lesser sac without signs of bowel ischemia or perforation. On exploratory laparotomy, a cecal bascule was found herniating into lesser sac via foramen of winslow. Upon reduction, the cecum appeared viable therefore a cecopexy was performed without bowel resection. Unlike cecal volvulus, cecal bascule consists of no axial rotation of the bowel with no mesenteric vascular compromise and therefore ischemia would only occur from intraluminal tension or extraluminal compression from the borders of foramen of winslow. The management of internal herniation of a cecal bascule is always surgical including anatomic resection or cecopexy. PMID:25516868

Makarawo, Tafadzwa; Macedo, Francisco Igor; Jacobs, Michael J

2014-01-01

66

Cecal bascule herniation into the lesser sac.  

PubMed

Cecal bascule is a rare cause of bowel obstruction in which a mobile cecum folds anteriorly and superiorly over the ascending colon. Herein, we present the first case of internal herniation of a cecal bascule into the lesser sac through the foramen of winslow, aiming at discussing radiological findings, differential diagnosis, and surgical management of this uncommon condition. A 75-year-old female presented to the emergency room with an 18-h history of sudden onset sharp, progressively worsening abdominal pain associated with vomiting. Physical exam revealed abdominal distention and epigastric tenderness while initial laboratory tests were unremarkable. Computed tomography of her abdomen and pelvis showed a loop of distended colon within lesser sac without signs of bowel ischemia or perforation. On exploratory laparotomy, a cecal bascule was found herniating into lesser sac via foramen of winslow. Upon reduction, the cecum appeared viable therefore a cecopexy was performed without bowel resection. Unlike cecal volvulus, cecal bascule consists of no axial rotation of the bowel with no mesenteric vascular compromise and therefore ischemia would only occur from intraluminal tension or extraluminal compression from the borders of foramen of winslow. The management of internal herniation of a cecal bascule is always surgical including anatomic resection or cecopexy. PMID:25516868

Makarawo, Tafadzwa; Macedo, Francisco Igor; Jacobs, Michael J

2014-12-16

67

Specific Lignin Accumulation in Granulated Juice Sacs of Citrus maxima.  

PubMed

Juice sac granulation occurring in pummelo fruits [Citrus maxima (Burm.) Merr.] is an undesirable trait, and the underlying mechanism remains unresolved. Previous studies have shown that lignin metabolism is closely associated with the process of juice sac granulation. Here, a method suitable for lignin isolation from pummelo tissues is established. Acetylated lignins from different pummelo tissues and cultivars were analyzed by HSQC NMR. The results showed that lignins in granulated juice sacs were characterized by an extremely high abundance of guaiacyl units (91.13-96.82%), in contrast to lignins from other tissues, including leaves, stems, and segment membranes. The abnormally accumulated lignins in granulated juice sacs were specific and mainly polymerized from coniferyl alcohol. No significant difference was found in lignin types among various cultivars. These findings indicated that the mechanism of juice sac granulation might be similar among various cultivars, although very different degrees of juice sac granulation can be observed. PMID:25419620

Wu, Jia-Ling; Pan, Teng-Fei; Guo, Zhi-Xiong; Pan, Dong-Ming

2014-12-17

68

Air sac adenocarcinoma of the sternum in a Quaker parrot (Myiopsitta monachus).  

PubMed

Respiratory neoplasia is rarely reported in avian species. A 17-yr-old Quaker parrot (Myiopsitta monachus) was admitted with a 2-wk history of anorexia, depression, and respiratory distress. Clinical examination revealed a large, firm mass in the left pectoral muscle. Radiology showed a mass silhouetting the heart and the liver. Supportive treatment was provided, but the bird died during the seventh weekly visit to drain thoracic cavity fluid. Necropsy showed a white, 3 x 3 x 2-cm, hard, gritty sternal mass. Histology showed a nonencapsulated, moderately differentiated air sac carcinoma of the sternum. Immunohistochemically the neoplasm was cytokeratin positive and vimentin and calretinin negative. This is the first report of an air sac neoplasia in a Quaker parrot and one of few respiratory tumors in psittacines. PMID:25632693

Loukopoulos, Panayiotis; Okuni, Julius Boniface; Micco, Teresa; Garcia, Jorge P; Uzal, Francisco A; Diab, Santiago S

2014-12-01

69

Open Reintervention for Aneurysmal Sac Enlargement after EVAR  

PubMed Central

We performed a late open reintervention for aneurysmal sac enlargement due to persistent type 2 endoleak (PT2EL) after EVAR for 8 of 286 patients. Surgical techniques are as follows: (1) The entire aneurysmal body was exposed. (2) All the aortic branched vessels were ligated. (3) The aneurysmal sac was opened followed by the performance of complete hemostasis. (4) An equine pericardium was wrapped and sutured to the aneurysmal sac to for reinforcement. This method is considered to be one of the feasible options for the treatment of aneurysmal sac re-enlargement after EVAR. PMID:25298845

Hiraoka, Arudo; Hirai, Yuuki; Tamura, Kentaro; Totsugawa, Toshinori; Ishida, Atsuhisa; Sakaguchi, Taichi; Yoshitaka, Hidenori

2014-01-01

70

Whisker Formation on SAC305 Soldered Assemblies  

NASA Astrophysics Data System (ADS)

This article describes the results of a whisker formation study on SAC305 assemblies, evaluating the effects of lead-frame materials and cleanliness in different environments: low-stress simulated power cycling (50-85°C thermal cycling), thermal shock (-55°C to 85°C), and high temperature/high humidity (85°C/85% RH). Cleaned and contaminated small outline transistors, large leaded quad flat packs (QFP), plastic leaded chip carrier packages, and solder balls with and without rare earth elements (REE) were soldered to custom designed test boards with Sn3Ag0.5Cu (SAC305) solder. After assembly, all the boards were cleaned, and half of them were recontaminated (1.56 µg/cm2 Cl-). Whisker length, diameter, and density were measured. Detailed metallurgical analysis on components before assembly and on solder joints before and after testing was performed. It was found that whiskers grow from solder joint fillets, where the thickness is less than 25 µm, unless REE was present. The influence of lead-frame and solder ball material, microstructure, cleanliness, and environment on whisker characteristics is discussed. This article provides detailed metallurgical observations and select whisker length data obtained during this multiyear testing program.

Meschter, S.; Snugovsky, P.; Bagheri, Z.; Kosiba, E.; Romansky, M.; Kennedy, J.; Snugovsky, L.; Perovic, D.

2014-11-01

71

Sebaceous carcinoma arising on actinic keratosis.  

PubMed

We report two cases of sebaceous carcinoma arising on actinic keratosis. The first patient, a 75-year-old female, had a granuloma pyogenicum-like tumor on her left temple, and the second patient, an 81-year-old female, developed a tumor with erythema on her left cheek. In both cases, histopathological examination revealed findings typical of sebaceous carcinoma in the center of the tumors, and in the periphery, actinic elastosis and intraepidermal proliferation of squamoid atypical cells without vacuolation was observed. Immunohistochemical examinations using six antibodies also revealed that neoplastic cells of both cases demonstrated sebaceous differentiation. These cases suggest that extraocular sebaceous carcinoma may arise from actinic keratosis. PMID:10882948

Ansai, S; Mihara, I

2000-01-01

72

Transcript profiles of maize embryo sacs and preliminary identification of genes involved in the embryo sac–pollen tube interaction  

PubMed Central

The embryo sac, the female gametophyte of flowering plants, plays important roles in the pollination and fertilization process. Maize (Zea mays L.) is a model monocot, but little is known about the interactions between its embryo sac and the pollen tube. In this study, we compared the transcript profiles of mature embryo sacs, mature embryo sacs 14–16 h after pollination, and mature nucelli. Comparing the transcript profiles of the embryo sacs before and after the entry of the pollen tube, we identified 3467 differentially expressed transcripts (3382 differentially expressed genes; DEGs). The DEGs were grouped into 22 functional categories. Among the DEGs, 221 genes were induced upon the entry of the pollen tube, and many of them encoded proteins involved in RNA binding, processing, and transcription, signaling, miscellaneous enzyme family processes, and lipid metabolism processes. Genes in the DEG dataset were grouped into 17 classes in a gene ontology enrichment analysis. The DEGs included many genes encoding proteins involved in protein amino acid phosphorylation and protein ubiquitination, implying that these processes might play important roles in the embryo sac–pollen tube interaction. Additionally, our analyses indicate that the expression of 112 genes encoding cysteine-rich proteins (CRPs) is induced during pollination and fertilization. The CRPs likely regulate pollen tube guidance and embryo sac development. These results provide important information on the genes involved in the embryo sac–pollen tube interaction in maize. PMID:25566277

Wang, Shuai Shuai; Wang, Fang; Tan, Su Jian; Wang, Ming Xiu; Sui, Na; Zhang, Xian Sheng

2014-01-01

73

79. Sac digital network (Sacdin), summary fault indicator at top, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

79. Sac digital network (Sacdin), summary fault indicator at top, south side - Ellsworth Air Force Base, Delta Flight, Launch Control Facility, County Road CS23A, North of Exit 127, Interior, Jackson County, SD

74

SAC Minutes March 26, 2014 TO: Simplified Acquisition Committee  

E-print Network

of Simplified Acquisition Policy and Services Office of Acquisition and Logistics Management SUBJECT: SAC on the NIH Learning Management System (LMS). 3. Expiring Lines Update was presented by Cristy Perrin, PPMB

Rau, Don C.

75

SAC Minutes April 24, 2013 TO: Simplified Acquisition Committee  

E-print Network

of Simplified Acquisition Policy and Services Office of Acquisition and Logistics Management SUBJECT: SAC processing time and errors associated with paper invoices. Pilot Phase 2 will assess process and system

Rau, Don C.

76

Epiploic appendicitis in inguinal hernia sac presenting an inguinal mass  

Microsoft Academic Search

Inguinal hernia sometimes surprises surgeons with its unexpected content. Epiploic appendagitis in hernia sac is a very rare\\u000a entity. We report a 60-year-old male patient with a painless inguinal mass. Surgical exploration showed a 4-cm mass beneath\\u000a the external oblique aponeurosis that consisted of a hernia sac containing an inflamed and remarkably swollen appendix epiploica\\u000a of the sigmoid colon secondary

H. Kulacoglu; H. Tumer; R. Aktimur; A. Kusdemir

2005-01-01

77

Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice  

PubMed Central

Tumor blood vessels are leaky and immature, which causes inadequate blood supply to tumor tissues resulting in hypoxic microenvironment and promotes metastasis. Here we have explored tumor vessel modulating activity of Sac-1004, a recently developed molecule in our lab, which directly potentiates VE-cadherin-mediated endothelial cell junction. Sac-1004 could enhance vascular junction integrity in tumor vessels and thereby inhibit vascular leakage and enhance vascular perfusion. Improved perfusion enabled Sac-1004 to have synergistic anti-tumor effect on cisplatin-mediated apoptosis of tumor cells. Interestingly, characteristics of normalized blood vessels namely reduced hypoxia, improved pericyte coverage and decreased basement membrane thickness were readily observed in tumors treated with Sac-1004. Remarkably, Sac-1004 was also able to inhibit lung and lymph node metastasis in MMTV and B16BL6 tumor models. This was in correlation with a reduction in epithelial-to-mesenchymal transition of tumor cells with considerable diminution in expression of related transcription factors. Moreover, cancer stem cell population dropped substantially in Sac-1004 treated tumor tissues. Taken together, our results showed that direct restoration of vascular junction could be a significant strategy to induce normalization of tumor blood vessels and reduce metastasis. PMID:24811731

Agrawal, Vijayendra; Maharjan, Sony; Kim, Kyeojin; Kim, Nam-Jung; Son, Jimin; Lee, Keunho; Choi, Hyun-Jung; Rho, Seung-Sik; Ahn, Sunjoo; Won, Moo-Ho; Ha, Sang-Jun; Koh, Gou Young; Kim, Young-Myeong; Suh, Young-Ger; Kwon, Young-Guen

2014-01-01

78

Automatic segmentation and classification of gestational sac based on mean sac diameter using medical ultrasound image  

NASA Astrophysics Data System (ADS)

Ultrasound is an effective multipurpose imaging modality that has been widely used for monitoring and diagnosing early pregnancy events. Technology developments coupled with wide public acceptance has made ultrasound an ideal tool for better understanding and diagnosing of early pregnancy. The first measurable signs of an early pregnancy are the geometric characteristics of the Gestational Sac (GS). Currently, the size of the GS is manually estimated from ultrasound images. The manual measurement involves multiple subjective decisions, in which dimensions are taken in three planes to establish what is known as Mean Sac Diameter (MSD). The manual measurement results in inter- and intra-observer variations, which may lead to difficulties in diagnosis. This paper proposes a fully automated diagnosis solution to accurately identify miscarriage cases in the first trimester of pregnancy based on automatic quantification of the MSD. Our study shows a strong positive correlation between the manual and the automatic MSD estimations. Our experimental results based on a dataset of 68 ultrasound images illustrate the effectiveness of the proposed scheme in identifying early miscarriage cases with classification accuracies comparable with those of domain experts using K nearest neighbor classifier on automatically estimated MSDs.

Khazendar, Shan; Farren, Jessica; Al-Assam, Hisham; Sayasneh, Ahmed; Du, Hongbo; Bourne, Tom; Jassim, Sabah A.

2014-05-01

79

The anuran vocal sac: a tool for multimodal signalling.  

PubMed

Although in anurans the predominant mode of intra- and intersexual communication is vocalization, modalities used in addition to or instead of acoustic signals range from seismic and visual to chemical. In some cases, signals of more than one modality are produced through or by the anuran vocal sac. However, its role beyond acoustics has been neglected for some time and nonacoustic cues such as vocal sac movement have traditionally been seen as an epiphenomenon of sound production. The diversity in vocal sac coloration and shape found in different species is striking and recently its visual properties have been given a more important role in signalling. Chemosignals seem to be the dominant communication mode in newts, salamanders and caecilians and certainly play a role in the aquatic life phase of anurans, but airborne chemical signalling has received less attention. There is, however, increasing evidence that at least some terrestrial anuran species integrate acoustic, visual and chemical cues in species recognition and mate choice and a few secondarily mute anuran species seem to fully rely on volatile chemical cues produced in glands on the vocal sac. Within vertebrates, frogs in particular are suitable organisms for investigating multimodal communication by means of experiments, since they are tolerant of disturbance by observers and can be easily manipulated under natural conditions. Thus, the anuran vocal sac might be of great interest not only to herpetologists, but also to behavioural biologists studying communication systems. PMID:25389375

Starnberger, Iris; Preininger, Doris; Hödl, Walter

2014-11-01

80

The anuran vocal sac: a tool for multimodal signalling  

PubMed Central

Although in anurans the predominant mode of intra- and intersexual communication is vocalization, modalities used in addition to or instead of acoustic signals range from seismic and visual to chemical. In some cases, signals of more than one modality are produced through or by the anuran vocal sac. However, its role beyond acoustics has been neglected for some time and nonacoustic cues such as vocal sac movement have traditionally been seen as an epiphenomenon of sound production. The diversity in vocal sac coloration and shape found in different species is striking and recently its visual properties have been given a more important role in signalling. Chemosignals seem to be the dominant communication mode in newts, salamanders and caecilians and certainly play a role in the aquatic life phase of anurans, but airborne chemical signalling has received less attention. There is, however, increasing evidence that at least some terrestrial anuran species integrate acoustic, visual and chemical cues in species recognition and mate choice and a few secondarily mute anuran species seem to fully rely on volatile chemical cues produced in glands on the vocal sac. Within vertebrates, frogs in particular are suitable organisms for investigating multimodal communication by means of experiments, since they are tolerant of disturbance by observers and can be easily manipulated under natural conditions. Thus, the anuran vocal sac might be of great interest not only to herpetologists, but also to behavioural biologists studying communication systems. PMID:25389375

Starnberger, Iris; Preininger, Doris; Hödl, Walter

2014-01-01

81

Adenocarcinoma arising from intracranial recurrent mature teratoma and featuring mutated KRAS and wild-type BRAF genes.  

PubMed

Malignant transformation or recurrence of intracranial mature teratoma is an extremely rare occurrence, compared to the usual ovarian counterpart. Previously, yolk sac tumor elements have been considered to be selective progenitors of enteric-type adenocarcinoma arising from intracranial germ cell tumors. However, the present case demonstrates the occurrence of enteric-type adenocarcinoma in recurrent intracranial mature cystic teratoma 12 years after gross total removal, a case of which has not previously been documented in the literature. The 11.5-cm long, dura mater-based tumor on the right fronto-temporal lobe displaced the brain; however, the patient had no neurologic symptoms or discomfort other than pus-like discharge on the scalp. Microscopic examinations revealed a small focus of adenocarcinoma and dysplastic colonic mucosa in the mature cystic teratoma. No immature elements were seen. The cystic wall was almost denuded and showed an exuberant xanthogranulomatous reaction with foreign-body type giant cells engulfing keratin materials and cholesterol clefts, suggesting that chronic inflammation due to repeated cyst wall rupture and the previous resection may contribute to malignant transformation. The adenocarcinoma showed strong immunohistochemical expression of CK20 and p53, but CK7 in patches. The molecular profile of the adenocarcinoma showed a mutation in KRAS and wild-type BRAF, which might be associated with malignant transformation of intracranial mature teratomas. In conclusion, the intracranial mature teratomas should require long-term follow-up, and clinicians, radiologists and pathologists should be aware of the potential for malignant progression of recurrent intracranial mature cystic teratoma despite gross total resection and no neurologic symptoms. PMID:25039399

Kim, Eun Soo; Kwon, Mi Jung; Song, Joon Ho; Kim, Dong Hoon; Park, Hye-Rim

2015-02-01

82

Vascular development and hemodynamic force in the mouse yolk sac  

NASA Astrophysics Data System (ADS)

Vascular remodeling of the mouse embryonic yolk sac is a highly dynamic process dependent on multiple genetic signaling pathways as well as biomechanical factors regulating proliferation, differentiation, migration, cell-cell and cell-matrix interactions. During this early developmental window, the initial primitive vascular network of the yolk sac undergoes a dynamic remodeling process concurrent with the onset of blood flow, in which endothelial cells establish a branched, hierarchical structure of large vessels and smaller capillary beds. In this review, we will describe the molecular and biomechanical regulators which guide vascular remodeling in the mouse embryonic yolk sac, as well as live imaging methods for characterizing endothelial cell and hemodynamic function in cultured embryos.

Garcia, Monica; Larina, Irina

2014-08-01

83

Sac Hygroma After Endovascular Abdominal Aortic Aneurysm Repair: Successful Treatment with Endograft Relining  

SciTech Connect

Aneurysm sac expansion following endovascular abdominal aortic aneurysm repair (EVAR) is typically associated with endoleaks that can be readily diagnosed on computed tomographic angiography (CTA), ultrasound, or catheter-directed arteriography. Sac hygromas are a cause of sac expansion without apparent endoleak and are presumed to be a result of ultrafiltration of serum manifested by accumulation of fibrinous, gelatinous material within the aneurysm sac following EVAR. Although there are no reported associated ruptures, sac expansion is nevertheless disconcerting and intervention is presumably indicated. We report a case of an expanding aneurysm after EVAR secondary to sac hygroma that was successfully treated with relining of the existing, original endograft.

Ryu, Robert K., E-mail: rryu@nmff.org; Palestrant, Sarah; Ryu, Jessica [Northwestern University, Feinberg School of Medicine (United States); Trachtenberg, Jeffrey [Interventional Radiology Institute at Decatur Memorial Hospital (United States)

2007-06-15

84

A novel laparoscopic specimen entrapment device to facilitate morcellation of large renal tumors  

Microsoft Academic Search

A reusable laparoscopic instrument consisting of a flexible deployment ring and a barrel was fabricated, and an impermeable sac was sutured to the flexible ring before entrapment of the specimen and morcellation. The laparoscopic specimen entrapment device facilitated placement of large renal tumors within a sac for morcellation.

Stephen E Pautler; Frank S Harrington; Glen W McWilliams; McClellan M Walther

2002-01-01

85

[Conjunctival tumors].  

PubMed

Conjunctival tumors are one of the most frequent of the eye and adnexa. They comprise a large variety of conditions, from benign lesions such as nevus or papilloma, to malignant lesions such as epidermoid carcinoma or melanoma which may threaten visual function and the life of the patient. They can arise from any cellular component, but the most frequent are of epithelial and melanocytic origin. Early diagnosis is essential for preventing ocular and systemic spread and to preserve visual function. In this paper we review the clinical characteristics of the most frequent conjunctival tumors, and we discuss tumor management. PMID:19173134

Saornil, M A; Becerra, E; Méndez, M C; Blanco, G

2009-01-01

86

SacY, a Transcriptional Antiterminator from Bacillus subtilis, Is Regulated by Phosphorylation In Vivo†  

PubMed Central

SacY antiterminates transcription of the sacB gene in Bacillus subtilis in response to the presence of sucrose in the growth medium. We have found that it can substitute for BglG, a homologous protein, in antiterminating transcription of the bgl operon in Escherichia coli. We therefore sought to determine whether, similarly to BglG, SacY is regulated by reversible phosphorylation in response to the availability of the inducing sugar. We show here that two forms of SacY, phosphorylated and nonphosphorylated, exist in B. subtilis cells and that the ratio between them depends on the external level of sucrose. Addition of sucrose to the growth medium after SacY phosphorylation in the cell resulted in its rapid dephosphorylation. The extent of SacY phosphorylation was found to be proportional to the cellular levels of SacX, a putative sucrose permease which was previously shown to have a negative effect on SacY activity. Thus, the mechanism by which the sac sensory system modulates sacB expression in response to sucrose involves reversible phosphorylation of the regulator SacY, and this process appears to depend on the SacX sucrose sensor. The sac system is therefore a member of the novel family of sensory systems represented by bgl. PMID:9457872

Idelson, Maria; Amster-Choder, Orna

1998-01-01

87

Carcinoid Tumors  

PubMed Central

Carcinoid tumors are rare, slow-growing neuroendocrine tumors arising from the enterochromaffin cells disseminated throughout the gastrointestinal and bronchopulmonary systems. Though they have been traditionally classified based upon the embryologic site of origin, morphologic pattern, and silver affinity, newer classification systems have been developed to emphasize the considerable clinical and histopathologic variability of carcinoid tumors found within each embryologic site of origin. These neoplasms pose a diagnostic challenge because they are often innocuous at the time of presentation, emphasizing the need for a multidisciplinary diagnostic approach utilizing biochemical analysis, standard cross-sectional imaging, and newer advances in nuclear medicine. Similarly, treatment of both primary and disseminated carcinoid disease reflects the need for a multidisciplinary approach, with surgery remaining the only curative modality. The prognosis for patients with these tumors is generally favorable, however can be quite variable and is related to the location of the primary tumor, extent of metastatic disease at initial presentation, and the time of diagnosis. PMID:19091780

Pinchot, Scott N.; Holen, Kyle; Sippel, Rebecca S.; Chen, Herbert

2010-01-01

88

Posterior semicircular canal dehiscence following endolymphatic sac surgery.  

PubMed

Posterior semicircular canal dehiscence is a rare otologic entity that presents with third window signs and symptoms. Petrous apex cholesteatoma, fibrous dysplasia, high riding jugular bulb, and eosinophilic granuloma have been reported to be associated with posterior semicircular canal dehiscence. Here we report a case of development of posterior semicircular canal dehiscence following an endolymphatic sac surgery for the first time. PMID:22689472

Kiumehr, Saman; Mahboubi, Hossein; Djalilian, Hamid R

2012-09-01

89

Final Report to: -English Nature (UK Marine SACs Project)  

E-print Network

`soft' bottom-up approaches need to be coupled with relatively `hard' top-down approaches. Final ReportFinal Report to: - English Nature (UK Marine SACs Project) An evaluation of approaches) An evaluation of approaches for promoting relevant authority and stakeholder participation in European Marine

Jones, Peter JS

90

Acute epiploic appendagitis in hernia sac: CT appearance  

Microsoft Academic Search

We describe an unusual cause of acute abdomen due to acute epiploic appendagitis located within an incisional hernia sac. The contrast-enhanced CT showed an oval fat density structure with surrounding inflammation in the transverse mesocolon. The contrast-enhanced CT findings of the inflammation of appendices epiploicae of the transverse colon were diagnostic in this case.

Ajay K. Singh; Debra Gervais; James Rhea; Peter Mueller; Robert A. Noveline

2005-01-01

91

The annular hematoma of the shrew yolk-sac placenta.  

PubMed

The annular hematoma of the shrew, Blarina brevicauda, is a specialized portion of the yolk-sac wall. In this study, we have examined the fine structure of the different cellular components of the anular hematoma. Small pieces of the gestation sacs from seven pregnant shrews were fixed in glutaraldehyde and osmium tetroxide and processed for transmission electron microscopy. In the area of the trophoblastic curtain, the maternal capillary endothelial cells were hypertrophied and syncytial trophoblast surrounded the capillaries. Cellular trophoblast covered part of the luminal surface of the curtain region, whereas masses of apparently degenerating syncytium were present on other areas of the surface. Maternal erythrocytes, released into the uterine lumen from the curtain region, were phagocytized and degraded by the columnar cells of the trophoblastic annulus. No evidence of iron or pigment accumulation was evident in the parietal endodermal cells underlying the annular trophoblast. Parietal endodermal cells were characterized by cuboidal shape, widely dilated intercellular spaces, and cytoplasm containing granular endoplasmic reticulum. Endodermal cells of the visceral yolk-sac accumulated large numbers of electron-dense granules as well as glycogen in their cytoplasm. Hemopoietic areas and vitelline capillaries were found subjacent to the visceral endoderm. The various portions of the yolk-sac wall of Blarina appear to perform complementary functions which are probably important in maternal-fetal iron transfer. PMID:677046

King, B F; Enders, A C; Wimsatt, W A

1978-05-01

92

SAC Minutes August 28, 2013 TO: Simplified Acquisition Committee  

E-print Network

of Simplified Acquisition Policy and Services Office of Acquisition and Logistics Management SUBJECT: SAC to complete the "eVIP View-Only Web-Based Training". The course is available on the NIH Learning Management System (LMS). Course duration is 60 minutes. All (2 and 3-way) pilot vendor awards must have correct

Rau, Don C.

93

SAC Minutes April 23, 2014 TO: Simplified Acquisition Committee  

E-print Network

of Simplified Acquisition Policy and Services Office of Acquisition and Logistics Management SUBJECT: SAC, enterprise data management, systems engineering, identity and access management, ERP IT infrastructure. 2. eGOS Demonstration was presented by Michelle Street, NITAAC Electronic Government Ordering System

Rau, Don C.

94

SAC Minutes July 24, 2013 TO: Simplified Acquisition Committee  

E-print Network

of Simplified Acquisition Policy and Services Office of Acquisition and Logistics Management SUBJECT: SAC. Supply Center and Self Service Stores was presented by George Martinez, Director, Division of Logistics deliveries. Storage at no cost for bulk or large purchases made through the New Business System (NBS) or Self

Rau, Don C.

95

Posterior Semicircular Canal Dehiscence Following Endolymphatic Sac Surgery  

PubMed Central

Posterior semicircular canal dehiscence is a rare otologic entity which presents with third window signs and symptoms. Petrous apex cholesteatoma, fibrous dysplasia, high riding jugular bulb, and eosinophilic granuloma have been reported to be associated with posterior semicircular canal dehiscence. Here we report a case of development of posterior semicircular canal dehiscence following an endolymaphatic sac surgery for the first time. PMID:22689472

Kiumehr, Saman; Mahboubi, Hossein; Djalilian, Hamid R.

2012-01-01

96

The Probabilistic Basis for the 2000 SAC/FEMA Steel Moment Frame C. Allin Cornell1  

E-print Network

The Probabilistic Basis for the 2000 SAC/FEMA Steel Moment Frame Guidelines C. Allin Cornell1 for the 2000 SAC/FEMA steel moment frame guidelines. The framework is based on realizing a performance being met. This format has been adopted in the SAC/FEMA guidelines. Keywords Probabilistic performance

Sweetman, Bert

97

Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis.  

PubMed

Neuropilins (NP1 and NP2) are vascular endothelial growth factor (VEGF) receptors that mediate developmental and tumor angiogenesis. Transgenic mice, in which both NP1 and NP2 were targeted (NP1(-/-)NP2(-/-)) died in utero at E8.5. Their yolk sacs were totally avascular. Mice deficient for NP2 but heterozygous for NP1 (NP1(+/-)NP2(-/-)) or deficient for NP1 but heterozygous for NP2 (NP1(-/-)NP2(+/-)) were also embryonic lethal and survived to E10-E10.5. The E10 yolk sacs and embryos were easier to analyze for vascular phenotype than the fragile poorly formed 8.5 embryos. The vascular phenotypes of these E10 mice were very abnormal. The yolk sacs, although of normal size, lacked the larger collecting vessels and had less dense capillary networks. PECAM staining of yolk sac endothelial cells showed the absence of branching arteries and veins, the absence of a capillary bed, and the presence of large avascular spaces between the blood vessels. The embryos displayed blood vessels heterogeneous in size, large avascular regions in the head and trunk, and blood vessel sprouts that were unconnected. The embryos were about 50% the length of wild-type mice and had multiple hemorrhages. These double NP1/NP2 knockout mice had a more severe abnormal vascular phenotype than either NP1 or NP2 single knockouts. Their abnormal vascular phenotype resembled those of VEGF and VEGFR-2 knockouts. These results suggest that NRPs are early genes in embryonic vessel development and that both NP1 and NP2 are required. PMID:11891274

Takashima, Seiji; Kitakaze, Masafumi; Asakura, Masanori; Asanuma, Hiroshi; Sanada, Shoji; Tashiro, Fumi; Niwa, Hitoshi; Miyazaki Ji, Jun-ichi; Hirota, Seiichi; Kitamura, Yukihiko; Kitsukawa, Takashi; Fujisawa, Hajime; Klagsbrun, Michael; Hori, Masatsugu

2002-03-19

98

De Novo Development and Progression of Endolymphatic Sac Tumour in von Hippel-Lindau Disease: An Observational Study and Literature Review  

PubMed Central

Endolymphatic sac tumors (ELST) are rare invasive lesions of the temporal bone that are commonly associated with von Hippel-Lindau disease. This report describes serial magnetic resonance imaging (MRI) and computed tomography (CT) findings over a period of 6 years in a 12-year-old patient who developed an ELST after 3.5 years surveillance for a cerebellar hemangioblastoma. A 1.5 × 8 mm tumor was identified on MRI within the endolymphatic duct when the patient presented with audiovestibular symptoms due to intralabyrinthine hemorrhage. The tumor demonstrated subsequent growth over 25 months until the patient agreed to undergo surgical resection by subtotal petrosectomy. De novo development and the natural history have been described only in six previous cases. MRI is regarded to be unreliable with respect to the ability to demonstrate an ELST in the presence of intralabyrinthine hemorrhage, with only two out of four previously reported patients demonstrating positive MRI findings. Little is known about the precise origin (endolymphatic duct versus sac), growth, and symptom correlation. This case highlights that new audiovestibular symptoms are a potential clinical clue and intralabyrinthine hemorrhage is a neuroimaging indicator for the presence of an ELST, which based on high-resolution MRI appears to originate in the endolymphatic duct rather than sac. PMID:24436921

Eze, Nwaneka; Huber, Alexander; Schuknecht, Bernhard

2013-01-01

99

Allosteric Activation of the Phosphoinositide Phosphatase Sac1 by Anionic Phospholipids  

PubMed Central

Sac family phosphoinositide phosphatases comprise an evolutionarily conserved family of enzymes in eukaryotes. Our recently determined crystal structure of the Sac phosphatase domain of yeast Sac1, the founding member of the Sac family proteins, revealed a unique conformation of the catalytic P-loop and a large positively charged groove at the catalytic site. We now report a unique mechanism for the regulation of its phosphatase activity. Sac1 is an allosteric enzyme that can be activated by its product phosphatidylinositol or anionic phospholipid phosphatidylserine. The activation of Sac1 may involve conformational changes of the catalytic P-loop induced by direct binding with the regulatory anionic phospholipids in the large cationic catalytic groove. These findings highlight the fact that lipid composition of the substrate membrane plays an important role in the control of Sac1 function. PMID:22452743

2012-01-01

100

Irreducible inguinal hernia with appendices epiploicae in the sac  

PubMed Central

Inguinal hernia has a nature to surprise surgeons with its unexpected contents. Appendix epiploicae alone in the hernial sac is a rare entity and that too if hypertrophied and presenting as irreducible hernia is still more uncommon. We report a 52-year-old male with complains of irreducible inguinal mass with little pain on Left side for seven days. A diagnosis of irreducible inguinal hernia was made and the patient was treated laparoscopically by Trans-Abdominal Pre-Peritoneal Mesh Hernioplasty (TAPP). As a surprise, content of the hernial sac was enlarged / hypertrophied appendix epiploicae of sigmoid colon with appendigitis. Patient also had and incidental hernia on the other side, which was repaired in the same sitting. Postoperative recovery of the patient was excellent. PMID:19547689

Jain, Mayank; Khanna, Shashi; Sen, Bimalendu; Tantia, Om

2008-01-01

101

Spectral Amplitude Coding (SAC)-OCDMA Network with 8DPSK  

NASA Astrophysics Data System (ADS)

Optical code division multiple access (OCDMA) technique is required to meet the increased demand for high speed, large capacity communications in optical networks. In this paper, the transmission performance of a spectral amplitude coding (SAC)-OCDMA network is investigated when a conventional single-mode fiber (SMF) is used as the transmission link using 8DPSK modulation. The DW has a fixed weight of two. Simulation results reveal that the transmission distance is limited mainly by the fiber dispersion when high coding chip rate is used. For a two-user SAC-OCDMA network operating with 2 Gbit/s data rate and two wavelengths for each user, the maximum allowable transmission distance is about 15 km.

Aldhaibani, A. O.; Aljunid, S. A.; Fadhil, Hilal A.; Anuar, M. S.

2013-09-01

102

SAC-C Mission and the Morning Constellation  

NASA Astrophysics Data System (ADS)

SAC-C is an international Earth observing satellite mission conceived as a partnership between CONAE and NASA, but with additional support in instrumentation and satellite development from the Danish DSRI, the Italian ASI, the French CNES and the Brazilian INPE. A Delta II rocket successfully launched it on November 21st, 2000, from Vandenberg AFB, California, USA. SAC-C has been designed primarily to fulfill the requirements of countries with large extension of territory or scarcely populated like Argentina. Its design is a good compromise between resolution and swath width that makes SAC-C an appropriate tool for global and high dynamic phenomena studies. There are ten instruments on board of SAC-C that will perform different studies, the Multispectral Medium Resolution Scanner (MMRS), provided by CONAE, Argentina, will help in the studies about desertification processes evaluation and their evolution in time (i.e., Patagonia, Argentina), to identify and predict agriculture production, to monitor flood areas and to make studies in coastal and fluvial areas. The MMRS will be associated with a High Resolution Technological Camera (HRTC), also provided by CONAE that will permit improvement in the MMRS resolution in the areas where it will be required. A High Sensitivity Technological Camera (HSTC) is also included in the mission. SAC-C also carries instruments to monitor the condition and dynamics of the terrestrial and marine biosphere and environment (GPS OccuLtation and Passive reflection Experiment (GOLPE)) from NASA/JPL. The Magnetic Mapping Payload, (MMP) developed by the Danish Space Research Institute helps to better understand the Earth's magnetic field and related Sun -Earth interactions .Italian Star Tracker (IST) and Italian Navigation Experiment (INES) developed by the Italian Space Agency, constitute a technological payload that will permit testing a fully autonomous system for attitude and orbit determination. Influence of space radiation on advanced components (ICARE), provided by CNES will permit improvement of risk estimation models for radiation effect on last generation integrated circuit technology. . On June 14th, 2000 CONAE and NASA signed an amendment to the Memorandum of Understanding for the SAC-C mission in order that the SAC-C satellite, were included in a constellation - named "Morning Constellation". It is integrated by USA satellites Landsat 7, EO 1, Terra, and Argentine SAC-C that feature on-board instruments from the United States, Argentina, Denmark, Italy, France, and Japan. The four satellite tracks on the Earth's surface are the same, their orbital height being 705 km and their inclination, 98.21 degrees. They cross the Equator at 10:00, 10:01, 10:15, and 10:30 hours, respectively (local time). Satellites comply with the World Wide Reference System. The Constellation has been working since March 2001 as a single mission and several cooperative activities have been undertaken and will be presented in this paper. Several jointly sponsored technical workshops have been held, and also collaborative spacecraft navigation experiments have been made. One of the objectives of the AM Constellation is the collaboration in the case of emergencies, NASA and CONAE agreed to give preference in those situation in the planification of their satellite acquisitions. From all the possible hazardous events, the most important for the country are fire and floods. In relation to fires, CONAE is presently adapting and developing the algorithms for using MODIS data to generate a fire map product. Additionally research on fire detection is carried out using the data from the HSTC camera. In relation to flooding, CONAE works in cooperation to national institutions providing the data and, in some cases, producing flood extent maps. In particular MMRS data is demonstrating to be very effective due to its spectral and radiometric resolutions, and its large swath which is well suited for extended countries like Argentina.

Colomb, F. R.; Alonso, C.; Hofmann, C.; Frulla, L.; Nollmann, I.; Milovich, J.; Kuba, J.; Ares, F.; Kalemkarian, M.

2002-01-01

103

Steatorrhoea in rats with an intestinal cul-de-sac  

Microsoft Academic Search

Steatorrhoea in rats with an intestinal cul-de-sac is mainly due to malabsorption of alimentary fats but faecal lipids of endogenous origin are also increased. Steatorrhoea depends on the site of the blind loop in the small intestine and is mainly caused by bacterial proliferation in the lumen of the gut. The aetiological role of Gram-positive anaerobic microbes, especially Clostridium welchii,

P. P. Hoet; H. Eyssen

1964-01-01

104

WITH-Loop-Folding in SAC - Condensing Consecutive Array Operations  

Microsoft Academic Search

This paper introduces a new compiler optimization called With-loop-folding. It is based on a special loop construct, the with-loop, which in the functional language SAC (for Single Assignment C) serves as a versatile vehicle to describe array operations\\u000a on an elementwise basis. A general mechanism for combining two of these With-loops into a single loop construct is presented. This mechanism

Sven-bodo Scholz

1997-01-01

105

Endometriosis in a spigelian hernia sac: an unexpected finding.  

PubMed

Describes the existence of endometrioma in a spigelian hernia sac. Spigelian Hernia is a rare ventral hernia, presenting difficulties in diagnosis and carrying a high incarceration and obstruction risk. Endometriomas occur due to implantation of endometrial cells into a surgical wound, most often after a cesarean delivery. A 37-year-old woman presented to our department with persistent abdominal pain, exacerbating during menses, and vomiting for 2 days. Physical examination revealed a mass-like lesion in the border between the left-upper and left-lower quadrant. Ultrasound examination was inconclusive and a computed tomography scan of the abdomen revealed an abdominal wall mass. During surgery, a spigelian hernia was found 5 to 7 cm above a previous cesarean incision. Tissue like "chocolate cysts" was present at the hernia sac. Hernia was repaired while tissue was excised and sent for histological examination that confirmed the diagnosis. Spigelian hernia is a hernia presenting difficulties in diagnosis and treatment. Endometrioma in a spigelian hernia sac is a rare diagnosis, confirmed only histologically. Clinical suspicion can be posed only through symptoms and thorough investigation. PMID:25594648

Moris, Demetrios; Michalinos, Adamantios; Vernadakis, Spiridon

2015-01-01

106

Substitution of silk stabilimenta for egg sacs by Allocyclosa bifurca (Araneae: Araneidae) suggests that silk stabilimenta function as camouflage devices  

Microsoft Academic Search

Summary The matching form and orientation of egg sacs and spiders, the match between egg sac color and that of the spider, ontogenetic changes in spider coloration that occur when egg sacs begin to be produced, differences in the positions of the spiders' legs during the day and at night, and coordinated changes in spider and egg sac colors in

William G. Eberhard

2003-01-01

107

SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase  

PubMed Central

Background SacPox, an enzyme from the extremophilic crenarchaeal Sulfolobus acidocaldarius (Sac), was isolated by virtue of its phosphotriesterase (or paraoxonase; Pox) activity, i.e. its ability to hydrolyze the neurotoxic organophosphorus insecticides. Later on, SacPox was shown to belong to the Phosphotriesterase-Like Lactonase family that comprises natural lactonases, possibly involved in quorum sensing, and endowed with promiscuous, phosphotriesterase activity. Results Here, we present a comprehensive and broad enzymatic characterization of the natural lactonase and promiscuous organophosphorus hydrolase activities of SacPox, as well as a structural analysis using a model. Conclusion Kinetic experiments show that SacPox is a proficient lactonase, including at room temperature. Moreover, we discuss the observed differences in substrate specificity between SacPox and its closest homologues SsoPox and SisLac together with the possible structural causes for these observations. PMID:24894602

2014-01-01

108

Quantitative analysis in spontaneous canine anal sac gland adenomas and carcinomas.  

PubMed

Stained cytological specimens from 7 canine anal sac gland adenomas and 11 canine anal sac gland carcinomas were analyzed by computer-assisted nuclear morphometry. In each case, the nuclei of at least 100 neoplastic cells were measured, and the mean nuclear area (MNA), mean nuclear perimeter (MNP), mean nuclear diameter (MND) and nuclear roundness (NR) were calculated. The study aimed to evaluate (1) the possibility of using nuclear cytomorphometry as an auxiliary diagnostic method to differentiate between canine anal sac gland adenomas and adenocarcinomas, and (2) the prognostic value of nuclear morphometry in canine anal sac gland adenocarcinomas. The results indicated that (1) MNA, MNP, MND and NR could be used as effective auxiliary tools for differential diagnosis between canine anal sac gland adenomas and adenocarcinomas, and (2) MNA, MNP and MND are reliable prognostic indicators for canine anal sac gland adenocarcinomas. PMID:18457852

Simeonov, Radostin; Simeonova, Galina

2008-12-01

109

The value of a neighborhood street with reference to the cul-de-sac  

Microsoft Academic Search

This article provides empirical evidence from Halifax, Nova Scotia, confirming the view that the type of neighborhood street can affect home values. The study identifies two categories of streets-the cul-de-sac and the grid-and measures their impacts on home value. The hypothesis that the cul-de-sac would attract premium values was supported by the study. In this study, the cul-de-sac generated a

Paul K. Asabere

1990-01-01

110

Some Factors Determining the Order of Elimination of Culs-de-sac in the Maze  

Microsoft Academic Search

Thirty-five white rats were put through an animal maze with nine culs-de-sac until the correct pathway was run nine times out of ten without any observable tendency to enter a cul-de-sac. The experiment was undertaken with a view to determine the kind of relation existing between the positions of the culs-de-sac and their temporal order of elimination, and the relative

C. J. Warden

1923-01-01

111

Individual variation in perfume blending in male greater sac-winged bats  

Microsoft Academic Search

Male greater sac-winged bats, Saccopteryx bilineata, use hovering flights to court females in their harem territory. While hovering, males fan a fragrant perfume from sac-like organs in the wing membrane towards the females. Each afternoon, males renew the perfumes of their wing sacs during a stereotypical and time-consuming behavioural sequence, which includes blending secretions from genital and gular glands. I

Christian C. Voigt

2002-01-01

112

Primitive intrapericardial teratoma associated with yolk sac tumour.  

PubMed

An intrapericardial vacuolated mass compressing and displacing the heart was diagnosed by echocardiography in a foetus of 22 weeks gestation. The birth was induced for early signs of foetal distress at 29 weeks and, after two initial pericardial evacuation procedures, the tumour was resected radically 7 days after birth at a weight of 1.55 kg. Mass histology showed teratoma associated with yolk sac tumour. We comment on the overall approach adopted after foetal diagnosis and the histopathological features of the tumour, and try to draw conclusions on patient outcome data. PMID:24447774

Cetrano, Enrico; Polito, Angelo; Carotti, Adriano

2015-01-01

113

Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment  

ClinicalTrials.gov

Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Metastatic Childhood Soft Tissue Sarcoma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Childhood Visual Pathway Glioma; Unspecified Childhood Solid Tumor, Protocol Specific

2013-09-27

114

Histopathology of tumors of the pineal region.  

PubMed

Pineal region tumors are heterogeneous lesions and include mainly pineal parenchymal tumors (PPTs), papillary tumors of the pineal region (PTPRs) and germ cell tumors (GCTs). This article describes the cystic pineal gland compared with normal tissue and histopathological features of the most frequent pineal region tumors. PPTs are subdivided into pineocytoma (grade I), pineoblastoma (grade IV) and tumors with intermediate differentiation (PPTIDs; grades II-III). A grading system based on the number of mitoses and neurofilament protein expression distinguishes low- from high-grade PPTID. PTPR is a new tumoral entity thought to originate from the subcommissural organ. GCTs include germinoma, embryonal carcinoma, teratoma, yolk sac tumor and choriocarcinoma and are often of mixed histologic composition. New histogenetic data for GCTs are presented. PMID:20465391

Fèvre-Montange, Michelle; Vasiljevic, Alexandre; Champier, Jacques; Jouvet, Anne

2010-05-01

115

Thymoma type B1 arising in a giant supradiaphragmatic thymolipoma.  

PubMed

Thymolipomas are uncommon tumors of the anterior mediastinum. They may extend into, but rarely stem from, the chest cavity. Furthermore, thymoma arising in a thymolipoma is extremely rare. We report a unique case of thymoma type B1 that originated form a giant thymolipoma located in the chest cavity, which was resected by a lateral thoracotomy in a 23-year-old woman. To our knowledge, this is the first reported case of thymoma type B1 arising within a giant thymolipoma. PMID:24887884

Kaplan, Tevfik; Han, Serdar; Han, Unsal; Atac, Gokce Kaan; Yanik, Serdar

2014-11-01

116

Characterization of the sacQ genes from Bacillus licheniformis and Bacillus subtilis.  

PubMed Central

The sacQ gene from Bacillus licheniformis was cloned and expressed in Bacillus subtilis. Deletion analysis shows that it encodes a 46-amino-acid polypeptide homologous to the B. subtilis sacQ gene product. The polypeptide, when it is overexpressed, activates the expression of a number of target genes in B. subtilis, all encoding secreted enzymes: alkaline protease, levansucrase, beta-glucanase(s), xylanase, and alpha-amylase. The maximum stimulations measured for alkaline protease and levansucrase were by a factor of 70 and 50, respectively, when the sacQ gene from B. licheniformis was present on a multicopy plasmid in B. subtilis. The sacQ genes from B. subtilis and B. licheniformis, cloned in the same multicopy plasmid, were compared under the same conditions. The sacQ gene from B. licheniformis was more efficient than the sacQ gene from B. subtilis in producing the hypersecretion phenotype. The sacQ structural genes from B. subtilis and B. licheniformis were placed under the control of the same inducible promoter. Hypersecretion was specifically obtained under conditions of full induction of the promoter. The target site of levansucrase regulation by sacQ was identified as a 440-base-pair fragment located in the 5' noncoding region of sacB, suggesting transcriptional control. Images PMID:3098732

Amory, A; Kunst, F; Aubert, E; Klier, A; Rapoport, G

1987-01-01

117

The PIKfyve–ArPIKfyve–Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines  

SciTech Connect

Highlights: •We assess PAS complex proteins and phosphoinositide levels in breast cancer cells. •Sac3 and ArPIKfyve are markedly elevated in triple-negative breast cancer cells. •Sac3 silencing inhibits proliferation in triple-negative breast cancer cell lines. •Phosphoinositide profiles are altered in breast cancer cells. •This is the first evidence linking high Sac3 with breast cancer cell proliferation. -- Abstract: The phosphoinositide 5-kinase PIKfyve and 5-phosphatase Sac3 are scaffolded by ArPIKfyve in the PIKfyve–ArPIKfyve–Sac3 (PAS) regulatory complex to trigger a unique loop of PtdIns3P–PtdIns(3,5)P{sub 2} synthesis and turnover. Whereas the metabolizing enzymes of the other 3-phosphoinositides have already been implicated in breast cancer, the role of the PAS proteins and the PtdIns3P–PtdIns(3,5)P{sub 2} conversion is unknown. To begin elucidating their roles, in this study we monitored the endogenous levels of the PAS complex proteins in cell lines derived from hormone-receptor positive (MCF7 and T47D) or triple-negative breast cancers (TNBC) (BT20, BT549 and MDA-MB-231) as well as in MCF10A cells derived from non-tumorigenic mastectomy. We report profound upregulation of Sac3 and ArPIKfyve in the triple negative vs. hormone-sensitive breast cancer or non-tumorigenic cells, with BT cell lines showing the highest levels. siRNA-mediated knockdown of Sac3, but not that of PIKfyve, significantly inhibited proliferation of BT20 and BT549 cells. In these cells, knockdown of ArPIKfyve had only a minor effect, consistent with a primary role for Sac3 in TNBC cell proliferation. Intriguingly, steady-state levels of PtdIns(3,5)P{sub 2} in BT20 and T47D cells were similar despite the 6-fold difference in Sac3 levels between these cell lines. However, steady-state levels of PtdIns3P and PtdIns5P, both regulated by the PAS complex, were significantly reduced in BT20 vs. T47D or MCF10A cell lines, consistent with elevated Sac3 affecting directly or indirectly the homeostasis of these lipids in TNBC. Together, our results uncover an unexpected role for Sac3 phosphatase in TNBC cell proliferation. Database analyses, discussed herein, reinforce the involvement of Sac3 in breast cancer pathogenesis.

Ikonomov, Ognian C., E-mail: oikonomo@med.wayne.edu; Filios, Catherine, E-mail: cfilios@med.wayne.edu; Sbrissa, Diego, E-mail: dsbrissa@med.wayne.edu; Chen, Xuequn, E-mail: xchen@med.wayne.edu; Shisheva, Assia, E-mail: ashishev@med.wayne.edu

2013-10-18

118

Abdominal delivery in the intact amniotic sac in twin pregnancy.  

PubMed

Abstract Objective: There has been an increasing trend for Caesarean deliveries in twin pregnancies over the last decades; preferred mode of delivery is still unclear. The article presents the mode of twin delivery within intact amniotic sac. Methods: The intrapartum courses in 70 matched twin pairs extracted by Caesarean section were analysed. Neonates were distributed to two groups - main (delivered "en caul") and control (delivered by conventional Caesarean section) groups, and subdivided according to gestational age at the time of delivery: 28-30 weeks, 31-33 weeks and 34-37 weeks. Neonates delivered first and second were matched by pairs. Results: The duration of Caesarean section was higher in the main group (delivered "en caul"). Apgar score at 5-th min depend on the gestational age at birth and was higher in main group. Mechanical ventilation term and length of hospital stay were lower in main group. Postnatal neurological examination showed lower incidence of brain damage in the main group. During the first year of life, neonates extracted within intact amniotic sac showed lower morbidity rate. This was correct also for pairs of neonates matched by delivery order. Conclusions: Presented method improves neonates' Apgar score, reduces the need for resuscitation and influence of intrapartum negative factors. The length of hospital stay and hospitalisation rate for the first year of life were also lower in neonates delivered "en caul", providing an economical benefit. PMID:25308206

Radzinsky, Viktor; Akhmadeev, Nariman; Fatkullin, Ildar; Fatkullin, Farid

2014-11-01

119

Oligodendroglial Ganglioglioma with Anaplastic Features Arising from the Thalamus  

Microsoft Academic Search

Anaplastic gangliogliomas with an oligodendroglial component are exceedingly rare tumors of uncertain growth potential. We report a 17-year-old female with a massive ganglioglioma containing anaplastic oligodendroglioma apparently arising from the thalamus. Two weeks after partial resection, she was started on a regimen including escalated doses of topotecan in combination with a fixed-dosage intensification regimen of cisplatin, cyclophosphamide and vincristine with

Mahlon D. Johnson; Mark T. Jennings; Steven A. Toms

2001-01-01

120

Cutaneous epithelioid melanocytic neurofibroma arising in a patient with neurofibromatosis-1.  

PubMed

Tumors expressing both melanocytic and neural features can pose a diagnostic challenge to the dermatopathologist and provoke questions regarding their lineage. We report a case of a tumor arising on the right cheek of a 9-year-old boy with neurofibromatosis type 1 (NF-1). This neoplasm featured nests of non-pigmented epithelioid cells arising within a neurofibroma. The entire tumor stained strongly with S100, whereas the epithelioid population stained with MART-1, HMB-45 and MiTF. The neoplasm shows only scattered Ki-67 positivity. This tumor represents a neurofibroma with portions that have undergone melanocytic differentiation (melanocytic neurofibroma). This exceedingly rare tumor represents a distinct entity from neurotized melanocytic nevi, combined melanocytic nevi or pigmented neurofibromas and provides further evidence that melanocytes arise indirectly from ventromedial neural crest-derived Schwann cell precursors. PMID:24472086

Novoa, Roberto A; Kovarik, Carrie L; Low, David W; Argenyi, Zsolt

2014-05-01

121

Pakistan Vet. J., 24(3): 2004 EFFECT OF EXPERIMENTAL YOLK SAC INFECTION WITH ESCHERICHIA  

E-print Network

Pakistan Vet. J., 24(3): 2004 125 EFFECT OF EXPERIMENTAL YOLK SAC INFECTION WITH ESCHERICHIA COLI, A and B containing 50 birds each. Experimental infection with E. coli was given intra yolk to group of fractional serum proteins. Results showed that yolk sac infection with E. coli led to gross pathological

Boyer, Edmond

122

Mammalian laryngseal air sacs add variability to the vocal tract impedance: Physical and computational modeling  

PubMed Central

Cavities branching off the main vocal tract are ubiquitous in nonhumans. Mammalian air sacs exist in human relatives, including all four great apes, but only a substantially reduced version exists in humans. The present paper focuses on acoustical functions of the air sacs. The hypotheses are investigated on whether the air sacs affect amplitude of utterances and?or position of formants. A multilayer synthetic model of the vocal folds coupled with a vocal tract model was utilized. As an air sac model, four configurations were considered: open and closed uniform tube-like side branches, a rigid cavity, and an inflatable cavity. Results suggest that some air sac configurations can enhance the sound level. Furthermore, an air sac model introduces one or more additional resonance frequencies, shifting formants of the main vocal tract to some extent but not as strongly as previously suggested. In addition, dynamic range of vocalization can be extended by the air sacs. A new finding is also an increased variability of the vocal tract impedance, leading to strong nonlinear source-filter interaction effects. The experiments demonstrated that air-sac-like structures can destabilize the sound source. The results were validated by a transmission line computational model. PMID:18647005

Riede, Tobias; Tokuda, Isao T.; Munger, Jacob B.; Thomson, Scott L.

2008-01-01

123

Massachusetts Department of Environmental Protection (MA DEP) Scientific Advisory Committee on Health Effects of Perchlorate (SAC)  

Microsoft Academic Search

The MA DEP Scientific Advisory Committee on Health Effects of Perchlorate (SAC) was comprised of an independent advisory committee, augmented with a number of specialists with expertise in subject areas covered in the Department's assessment of the health effects of perchlorate. The SAC provided input and peer review of the MA DEP perchlorate toxicology assessment and RfD development.

Robert Utiger; Rosalind Brown; Charles Emerson

124

pH sensing via bicarbonate-regulated “soluble” adenylyl cyclase (sAC)  

PubMed Central

Soluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3?, 5? monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO?3) ions. In living cells, HCO?3 ions are in nearly instantaneous equilibrium with carbon dioxide (CO2) and pH due to the ubiquitous presence of carbonic anhydrases. Numerous biological processes are regulated by CO2, HCO?3, and/or pH, and in a number of these, sAC has been shown to function as a physiological CO2/HCO3/pH sensor. In this review, we detail the known pH sensing functions of sAC, and we discuss two highly-studied, pH-dependent pathways in which sAC might play a role. PMID:24324443

Rahman, Nawreen; Buck, Jochen; Levin, Lonny R.

2013-01-01

125

Development of the endolymphatic sac in chick embryos, with reference to the degradation of otoconia  

NASA Technical Reports Server (NTRS)

The endolymphatic sac of chick embryos (from embryonic day 7 to 1-day-old chicks) was studied light- and electron-microscopically. At stage 30-31 (embryonic day 7-7.5), the epithelial cells of the endolymphatic sac were cuboidal to columnar in shape. Microvilli were relatively well developed. The intercellular space was wide. In the endolymphatic space of the endolymphatic sac, varying shapes and sizes of otoconia-like bodies were often observed. Intracytoplasmic phagosomes containing these bodies were rarely found. After stage 37 (embryonic day 11), otoconia-like bodies in the endolymphatic sac decreased in number and size. They were almost the same as the otoconia in the macular organs, ultrastructurally. These findings indicate that the endolymphatic sac of the chick embryos may possess the function of otoconial degradation and removal of calcium from otoconia.

Yoshihara, T.; Kaname, H.; Narita, N.; Ishii, T.; Igarashi, M.; Fermin, C. D.

1992-01-01

126

Endometriosis within a left-sided inguinal hernia sac.  

PubMed

Endometriosis is a common gynecologic disorder wherein ectopic endometrial glands and stroma are found at extrauterine sites. Extrapelvic endometriosis is a well-documented, yet rare, disease entity that can affect almost any organ system. Inguinal endometriosis is an extremely rare disease entity characterized by tender inguinal swelling. Here we report a case of a sudden-onset and acutely painful left inguinal hernia with concordant endometriosis. A review of the literature is presented. The presence of isolated endometriosis contained within a left-sided inguinal hernia sac has, to our knowledge, never been reported. Often diagnosed incidentally or on histologic examination, general surgeons should consider inguinal endometriosis in the differential diagnosis of inguinal masses, even in the absence of catamenial symptoms. Surgical excision, with gynecologic follow-up, is locally curative and the treatment of choice for inguinal endometriosis. PMID:24876515

Albutt, Katherine; Glass, Charity; Odom, Stephen; Gupta, Alok

2014-01-01

127

Ground water in the Cul-de-Sac Plain, Haiti  

USGS Publications Warehouse

The Cul-de-Sac Plain is perhaps the most important agricultural area in Haiti because of its nearness and accessibility to Port-au-Prince, the nation's capital, metropolis, and principal seaport. Most of the agricultural produce consumed in Port-au-Prince as well as a considerable part of that exported from Haiti is grown in the plain. Because of variable and poorly distributed rainfall, high temperature, and high evaporation, semiarid climatic conditions prevail in the plain. Irrigation is, therefore, necessary for successful farming. There are no regulatory or storage facilities on the streams that enter the plain, but the mean and low-water stream flow and the discharge of springs are almost entirely appropriated for irrigation. Ground water has been utilized for irrigation to an increasing extent by the Haitian American Sugar Company, which has put down about 100 wells in the plain since 1919. Outside the existing irrigated areas of the plain are large tracts of potentially irrigable land that are uncultivated and agriculturally unproductive for lack of water. The object of the present study was to determine the possibilities of bringing these lands into cultivation by irrigation from wells. This study was part of a larger program of the Food Supply Division, Institute of Inter-American Affairs, to increase the production of food in Haiti. From September through November 1948 the senior author, a member of the U. S. Geological Survey, spent three months in the field in an investigation of the geology and ground-water resources of the Cul-de-Sac Plain. He was ably assisted by Mr. Rémy C. Lemoine, Haitian engineer-geologist, employed by the Food Supply Division. The field work included principally the geologic mapping of' the plain and the adjacent mountain borders, a ground-water inventory of existing wells and springs, and a general evaluation of significant geologic and hydrologic features.

Taylor, George C., Jr.; Lemoine, Rémy C.

1949-01-01

128

Melanoma Arising after Imiquimod Use  

PubMed Central

Imiquimod belongs to the class of 1H-imidazo-[4,5-c]quinolones—drugs originally developed as nucleoside analogues with the aim of finding new potential antiviral agents (Harrison et al., 1988). Indeed, Imiquimod was first released as treatment for genital warts before its actions against skin cancer were studied. Imiquimod is a relatively small sized molecule (Mr = 240.3) and is hydrophobic, allowing it to penetrate the skin epidermal barrier and therefore making it suitable for topical formulations (Gerster et al., 2005). Imiquimod has shown itself effective against skin cancers and precancerous lesions, especially basal cell cancers and actinic keratosis (Salasche et al., 2002, Beutner et al., 1999). There have been reports of Imiquimod being used as topical treatment against cutaneous metastases of melanoma and some authors have reported its use as first-line therapy against melanoma in situ (Smyth et al., 2011, Gagnon, 2011). We report a case of an invasive malignant melanoma arising de novo at the specific site of application of Imiquimod (Aldara cream 5%) for a biopsy-proven superficial BCC. Therefore while Imiquimod has added to our topical armamentarium against skin cancer, care must be exercised in prescribing this treatment and it is especially important to follow up patients regularly. PMID:25431597

2014-01-01

129

Transitional cell-type papillary carcinoma of the lacrimal sac manifesting as a medial canthal skin lesion.  

PubMed

A 61-year-old man presented with a 2.5?cm fungating skin lesion above the right medial canthus, accompanied by fluctuance and subtle inferotemporal globe displacement. The tumor had erupted 2 months previously and grown rapidly. Computed tomography (CT) revealed a 4.2?×?2.8?×?2.1?cm exophytic mass of the right orbit, superimposed on chronic dacryocystitis. Incisional biopsy disclosed faulty epithelial maturation sequence with possible basement membrane invasion. The patient underwent wide excision with medial maxillectomy, inferior turbinectomy, ethmoidectomy, and partial rhinectomy. The orbital floor was then reconstructed; a paramedian forehead flap and myocutaneous cheek advancement flap were used to fill cutaneous defects. All surgical margins were negative on both frozen and permanent sections. Definitive histopathology was consistent with transitional cell type papillary carcinoma of the lacrimal sac. Adjuvant radiotherapy was recommended, but the patient has declined further treatment. He remains recurrence-free at one year. PMID:24911210

Erickson, Benjamin P; Modi, Yasha S; Ko, Marcus J; Hussain, Rehan M; Gomez-Fernandez, Carmen; Johnson, Thomas E

2014-10-01

130

Small cell tumors of the thyroid gland: a review.  

PubMed

The small cell group of thyroid tumors that includes lymphoma, poorly differentiated carcinoma, medullary carcinoma, secondary neoplasms, as well as tumors with uncertain histogenesis, remains as a valid diagnostic cul-de-sac due to its heterogeneous constitution. The existence of small cell thyroid tumors with EWSR1-FLI1 rearrangement together with neuroendocrine and/or carcinomatous differentiation raises not only differential diagnostic problems but also a very interesting therapeutic dilemma. This review explores the classification of small cell tumors of the thyroid taking into account the immunophenotype and molecular profile of such tumors. PMID:24275884

Eloy, Catarina; Cameselle-Teijeiro, José Manuel; Rousseau, Emmanuel; Sobrinho-Simões, Manuel

2014-05-01

131

Endometrial Stromal Sarcoma Arising in Colorectal Endometriosis: A Case Report and Review of the Literature  

PubMed Central

Extrauterine endometrial stromal sarcoma (ESS) arising in endometriosis is extremely rare, particularly in the colorectum. It should always be included in the differential diagnosis of primary tumors originating from gastrointestinal tract in females, given that preoperative endoscopical biopsy may reveal no specific changes. We reported a case of ESS arising in colorectal endometriosis and reviewed the previous 7 cases reported in the English literature. Our patient, who was unavailable for tumor resection and refused further adjuvant therapy, played a role in representing the natural history of low-grade extragenital ESS. This case was the only death from ESS arising in colorectal endometriosis. PMID:25648532

Wang, Qiao; Zhao, Xia; Han, Ping

2015-01-01

132

Endometrial stromal sarcoma arising in colorectal endometriosis: a case report and review of the literature.  

PubMed

Extrauterine endometrial stromal sarcoma (ESS) arising in endometriosis is extremely rare, particularly in the colorectum. It should always be included in the differential diagnosis of primary tumors originating from gastrointestinal tract in females, given that preoperative endoscopical biopsy may reveal no specific changes. We reported a case of ESS arising in colorectal endometriosis and reviewed the previous 7 cases reported in the English literature. Our patient, who was unavailable for tumor resection and refused further adjuvant therapy, played a role in representing the natural history of low-grade extragenital ESS. This case was the only death from ESS arising in colorectal endometriosis. PMID:25648532

Wang, Qiao; Zhao, Xia; Han, Ping

2015-01-01

133

EFFICACITE D"UN ARRET-BARRAGE DECLENCHE VIS-A-VIS DES EXPLOSIONS EN CUL-DE-SAC  

E-print Network

"91-25" EFFICACITE D"UN ARRET-BARRAGE DECLENCHE VIS-A-VIS DES EXPLOSIONS EN CUL-DE-SAC par C particulier, les galeries en creusement ("cul-de-sac") posent des problemes de securite car ä proximite du evoques ci-dessus sont insuffisants pour proteger les culs-de-sac car, en premier lieu, la neutrali

Boyer, Edmond

134

Castor sacs and anal glands of the north american beaver ( Castor canadensis ): their histology, development, and relationship to scent communication  

Microsoft Academic Search

Both sexes of beavers possess a pair of castor sacs and a pair of anal glands located in paired subcutaneous cavities between the pelvis and the base of the tail. The castor sacs are not glandular in the histological sense, hence references to these structures as preputial glands or castor glands are misnomers. The wall of the castor sacs is

Jon M. Walro; Gerald E. Svendsen

1982-01-01

135

Nordic rattle: the hoarse vocalization and the inflatable laryngeal air sac of reindeer (Rangifer tarandus)  

PubMed Central

Laryngeal air sacs have evolved convergently in diverse mammalian lineages including insectivores, bats, rodents, pinnipeds, ungulates and primates, but their precise function has remained elusive. Among cervids, the vocal tract of reindeer has evolved an unpaired inflatable ventrorostral laryngeal air sac. This air sac is not present at birth but emerges during ontogenetic development. It protrudes from the laryngeal vestibulum via a short duct between the epiglottis and the thyroid cartilage. In the female the growth of the air sac stops at the age of 2–3 years, whereas in males it continues to grow up to the age of about 6 years, leading to a pronounced sexual dimorphism of the air sac. In adult females it is of moderate size (about 100 cm3), whereas in adult males it is large (3000–4000 cm3) and becomes asymmetric extending either to the left or to the right side of the neck. In both adult females and males the ventral air sac walls touch the integument. In the adult male the air sac is laterally covered by the mandibular portion of the sternocephalic muscle and the skin. Both sexes of reindeer have a double stylohyoid muscle and a thyroepiglottic muscle. Possibly these muscles assist in inflation of the air sac. Head-and-neck specimens were subjected to macroscopic anatomical dissection, computer tomographic analysis and skeletonization. In addition, isolated larynges were studied for comparison. Acoustic recordings were made during an autumn round-up of semi-domestic reindeer in Finland and in a small zoo herd. Male reindeer adopt a specific posture when emitting their serial hoarse rutting calls. Head and neck are kept low and the throat region is extended. In the ventral neck region, roughly corresponding to the position of the large air sac, there is a mane of longer hairs. Neck swelling and mane spreading during vocalization may act as an optical signal to other males and females. The air sac, as a side branch of the vocal tract, can be considered as an additional acoustic filter. Individual acoustic recognition may have been the primary function in the evolution of a size-variable air sac, and this function is retained in mother–young communication. In males sexual selection seems to have favoured a considerable size increase of the air sac and a switch to call series instead of single calls. Vocalization became restricted to the rutting period serving the attraction of females. We propose two possibilities for the acoustic function of the air sac in vocalization that do not exclude each other. The first assumes a coupling between air sac and the environment, resulting in an acoustic output that is a combination of the vocal tract resonance frequencies emitted via mouth and nostrils and the resonance frequencies of the air sac transmitted via the neck skin. The second assumes a weak coupling so that resonance frequencies of the air sac are lost to surrounding tissues by dissipation. In this case the resonance frequencies of the air sac solely influence the signal that is further filtered by the remaining vocal tract. According to our results one acoustic effect of the air sac in adult reindeer might be to mask formants of the vocal tract proper. In other cervid species, however, formants of rutting calls convey essential information on the quality of the sender, related to its potential reproductive success, to conspecifics. Further studies are required to solve this inconsistency. PMID:17310544

Frey, Roland; Gebler, Alban; Fritsch, Guido; Nygrén, Kaarlo; Weissengruber, Gerald E

2007-01-01

136

Bone tumor  

MedlinePLUS

Tumor - bone; Bone cancer; Primary bone tumor; Secondary bone tumor ... include: Genetic defects passed down through families Radiation Injury In ... or metastatic bone tumors. They behave very differently ...

137

Repair of the inguinal hernia using the hernia sac to correct the abdominal wall defect  

PubMed Central

Summary Surgery of the inguinal hernia is a challenge for the great incidence of recurrences. The aim of this study is demonstrate the usefulness of hernia sac in the repair of inguinal hernia. In 200 patients the hernia sac was used to reinforce the abdominal wall. The patients have been observed two years along and still now few recurrences (20%) have been observed. The hernia sac can be used to repair the inguinal hernia because it’s a patient’s tissue with no inflammation and rejection. PMID:24091173

LAIZO, A.; da FONSECA DELGADO, F.E.; TERZELLA, M.R.; da SILVA, A. LÁZARO

2013-01-01

138

Analysis for stress environment in the alveolar sac model  

PubMed Central

Better understanding of alveolar mechanics is very important in order to avoid lung injuries for patients undergoing mechanical ventilation for treatment of respiratory problems. The objective of this study was to investigate the alveolar mechanics for two different alveolar sac models, one based on actual geometry and the other an idealized spherical geometry using coupled fluid-solid computational analysis. Both the models were analyzed through coupled fluid-solid analysis to estimate the parameters such as pressures/velocities and displacements/stresses under mechanical ventilation conditions. The results obtained from the fluid analysis indicate that both the alveolar geometries give similar results for pressures and velocities. However, the results obtained from coupled fluid-solid analysis indicate that the actual alveolar geometry results in smaller displacements in comparison to a spherical alveolar model. This trend is also true for stress/strain between the two models. The results presented indicate that alveolar geometry greatly affects the pressure/velocities as well as displacements and stresses/strains. PMID:24932320

Pidaparti, Ramana M.; Burnette, Matthew; Heise, Rebecca L.; Reynolds, Angela

2014-01-01

139

Observational Opportunities with the CUBIC Experiment on SAC-B  

NASA Astrophysics Data System (ADS)

The CUBIC experiment on the SAC-B satellite is now collecting data on the Diffuse X-Ray Background and bright point sources over an energy range of 0.2 - 10 keV with energy resolution ranging from 40 - 160 eV over this bandpass. CUBIC observations, several of which are discussed in other posters at this session, provide 2 - 4 high quality spectra per week. CUBIC was built as a PI-class instrument, and at present data rights are divided between Penn State (90%) and Leicester University (10%). We present the observing plan for the first six months of CUBIC operations. We are currently collaborating with several astronomers who are not on the CUBIC team but have expressed interest in one or more of these targets. We invite additional collaborations on targets which are not currently assigned to a specific observer. In order to make these data more accessible to the astronomical community, we are proposing to institute a modest Guest Investigator program. If supported by ADP funding, this would permit observing requests from outside astronomers and would place a large fraction of the CUBIC data in a public archive at the HEASARC.

Nousek, J. A.; Burrows, D. N.; Moskalenko, E. I.

1996-12-01

140

Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels  

PubMed Central

In adult mammals, leukocyte recruitment follows a well-defined cascade of adhesion events enabling leukocytes to leave the circulatory system and transmigrate into tissue. Currently, it is unclear whether leukocyte recruitment proceeds in a similar fashion during fetal development. Considering the fact that the incidence of neonatal sepsis increases dramatically with decreasing gestational age in humans, we hypothesized that leukocyte recruitment may be acquired only late during fetal ontogeny. To test this, we developed a fetal intravital microscopy model in pregnant mice and, using LysEGFP (neutrophil reporter) mice, investigated leukocyte recruitment during fetal development. We show that fetal blood neutrophils acquire the ability to roll and adhere on inflamed yolk sac vessels during late fetal development, whereas at earlier embryonic stages (before day E15), rolling and adhesion were essentially absent. Accordingly, flow chamber experiments showed that fetal EGFP+ blood cells underwent efficient adhesion only when they were harvested on or after E15. Fluorescence-activated cell sorter analysis on EGFP+ fetal blood cells revealed that surface expression of CXCR2 and less pronounced P-selectin glycoprotein ligand-1 (PSGL-1) begin to increase only late in fetal life. Taken together, our findings demonstrate that inflammation-induced leukocyte recruitment is ontogenetically regulated and enables efficient neutrophil trafficking only during late fetal life. PMID:23525796

Quackenbush, Elizabeth J.; Sushkova, Natalia; Altstätter, Johannes; Nussbaum, Claudia; Schmid, Stephan; Pruenster, Monika; Kurz, Angela; Margraf, Andreas; Steppner, Alina; Schweiger, Natalie; Borsig, Lubor; Boros, Ildiko; Krajewski, Nele; Genzel-Boroviczeny, Orsolya; Jeschke, Udo; Frommhold, David

2013-01-01

141

SAC-B GaAs solar array  

NASA Astrophysics Data System (ADS)

This paper describes the electrical and mechanical design of the GaAs solar array of SAC-B, an Argentinian scientific satellite, planned for launch in 1995 into a 550-km circular orbit by Pegasus vehicle. The solar array is made up of four deployable wings, embodying approximately 1000 LPE GaAs solar cells, (30 x 41 sq mm), capable of providing about 215 W at 28 V at EOL. The mechanical structure of each panel comprises an aluminum honeycomb structure with carbon fiber skins; the active facesheet is covered with an insulating layer of kapton/fiberglass. Each panel is attached via a pair of hinges to the spacecraft body while a restraint/release mechanism holds the other panel edge to the spacecraft. Different considerations have been taken into account for the electrical and mechanical design of the solar array: geometrical constraints of the Pegasus static envelope and the satellite for the panel dimensioning, mission degradation factors, minimization of the magnetic moment, and realiability requirements. Several environmental tests (including thermal vacuum and vibration) are foreseen at panel and/or satellite level to verify performances during the mission.

Brambilla, L.; Caon, A.; Contini, R.; D'Accolti, G.; Rossi, E.; Verzeni, G.; Flores, C.; Paletta, F.; Pedrazzoli, G.; Grattarola, M.

1993-10-01

142

Histological and histochemical analyses of the cuttlebone sac of the golden cuttlefish Sepia esculenta  

NASA Astrophysics Data System (ADS)

The secretion function of mantle is closely related to shell formation in some bivalves and gastropods. Up to now, few researches have been reported for cuttlebone formation in the class Cephalopoda. In this study, the structure and secretion function of cuttlebone sac of the golden cuttlefish Sepia esculenta was analyzed using the histological and histochemical methods. The results showed that high and columnar cells located in sac epithelium, and flat cells existed near the base membrane. A lot of fibroblasts were found in the lateral mantle collective tissue. Some mucus, mucopolysaccharide and alkaline phosphatase (ALP) were found in the sac. The ultrastructural characteristics of Quasi-connective-tissue-calcium cells (QCTCC) were observed using a transmission electron microscope (TEM). The relationship between cuttlebone sac secretion function and shell formation was discussed.

Zheng, Xiaodong; Xiao, Shu; Wang, Zhaoping; Wang, Rucai

2007-10-01

143

Molecular characterization of oct4-expressing yolk sac endoderm stem cell lines.  

E-print Network

The extraembryonic endoderm (XEN) defines the yolk sac, a set of membranes that provide essential support for mammalian embryos. Recently, the committed XENprecursor was identified in the embryonic Inner Cell Mass (ICM) as a group of cells...

Debeb, Bisrat Godefay

2009-05-15

144

Laparoscopic Mobilization of the Rectosigmoid and Excision of the Obliterated Cul-de-sac  

Microsoft Academic Search

Study ObjectiveTo evaluate the feasibility and surgical and clinical outcomes of laparoscopic excision of anterior recto- sigmoid wall endometriosis and en bloc dissection of the obliterated cul-de-sac.

Jackie Hollett-Caines; George A. Vilos; Deborah Anne Penava

2003-01-01

145

Histological evaluation of pearl-sac development in the Concho Pearly Mussel (Cyrtonaias tampicoens)  

E-print Network

The purpose of this project was to assess the wound repair properties and epithelial cell proliferation in the processes necessary to develop a pearl-sac in the mantle of the Concho Pearly Mussel (Uniodidea: Cyrtonaias tampicoens). Samples...

Tower, Stephan N.

2002-01-01

146

Coagulopathy associated with sac reperfusion for reversing paraplegia after endovascular repair of type II thoracoabdominal aneurysm.  

PubMed

Sac perfusion may be helpful in preventing or reversing spinal cord injury after endovascular repair of thoracoabdominal aneurysms and it has been used as an adjunct to the standard physiologic measures of sustained hypertension and cerebrospinal fluid drainage. Coagulopathy as a result of endoleak after endovascular aneurysm repair has been reported, and very rare cases of treatment after repair of these endoleaks have been described. We report a 73-year-old man who had endovascular repair of a type II thoracoabdominal aneurysm with a branched stent graft. Sac reperfusion was initiated to manage postoperative paraplegia. The paraplegia partially resolved but severe hemorrhagic complications developed that were attributed to sac perfusion-related hyperfibrinolysis. Discontinuation of sac perfusion resolved the coagulopathy but resulted in paraplegia. PMID:23988546

Lioupis, Christos; Katsanos, Konstantinos; Clough, Rachel; Matharu, Nick; Modarai, Bijan; Carrell, Tom; Taylor, Peter

2013-11-01

147

Performance Evaluation of Hybrid SCM/SAC-OCDMA Transmissions System using Dynamic Cyclic Shift Code  

NASA Astrophysics Data System (ADS)

In this paper, the performance of a hybrid scheme of Subcarrier Multiplexing (SCM) technique in a Spectral Amplitude Coding (SAC) Optical Code Division Multiple Access (CDMA) transmissions system is evaluated. The hybrid system is design using new code family; we call it Dynamic Cyclic Shift (DCS) code. The DCS code design for SAC-OCDMA system to reduce the effect of Multi Access Interference due to it property of low cross-correlation (?C ? 1) between code words. In contrast, the SCM scheme shows the ability to increase the data rate of SAC-OCDMA system. Consequently, the hybrid SCM/SAC-OCDMA system could be one promising solution to the high-capacity access network with low cost effective, good flexibility and enhanced security, which makes an attractive candidate for next-generation broadband access network.

Abd, Thanaa Hussein; Aljunid, S. A.; Fadhil, Hilal Adnan; Radhi, Ibrahim Fadhil; Saad, N. M.

2012-12-01

148

38 CFR Appendix A to Part 41 - Data Collection Form (Form SF-SAC)  

Code of Federal Regulations, 2010 CFR

...SF-SAC and instructions for its completion may be obtained from the following Web page: http://harvester.census.gov/fac/collect/sfsac_01.pdf . It is also available from the address provided in §...

2010-07-01

149

Evidence for Avian Intrathoracic Air Sacs in a New Predatory Dinosaur from Argentina  

PubMed Central

Background Living birds possess a unique heterogeneous pulmonary system composed of a rigid, dorsally-anchored lung and several compliant air sacs that operate as bellows, driving inspired air through the lung. Evidence from the fossil record for the origin and evolution of this system is extremely limited, because lungs do not fossilize and because the bellow-like air sacs in living birds only rarely penetrate (pneumatize) skeletal bone and thus leave a record of their presence. Methodology/Principal Findings We describe a new predatory dinosaur from Upper Cretaceous rocks in Argentina, Aerosteon riocoloradensis gen. et sp. nov., that exhibits extreme pneumatization of skeletal bone, including pneumatic hollowing of the furcula and ilium. In living birds, these two bones are pneumatized by diverticulae of air sacs (clavicular, abdominal) that are involved in pulmonary ventilation. We also describe several pneumatized gastralia (“stomach ribs”), which suggest that diverticulae of the air sac system were present in surface tissues of the thorax. Conclusions/Significance We present a four-phase model for the evolution of avian air sacs and costosternal-driven lung ventilation based on the known fossil record of theropod dinosaurs and osteological correlates in extant birds: (1)?Phase I—Elaboration of paraxial cervical air sacs in basal theropods no later than the earliest Late Triassic. (2)?Phase II—Differentiation of avian ventilatory air sacs, including both cranial (clavicular air sac) and caudal (abdominal air sac) divisions, in basal tetanurans during the Jurassic. A heterogeneous respiratory tract with compliant air sacs, in turn, suggests the presence of rigid, dorsally attached lungs with flow-through ventilation. (3)?Phase III—Evolution of a primitive costosternal pump in maniraptoriform theropods before the close of the Jurassic. (4)?Phase IV—Evolution of an advanced costosternal pump in maniraptoran theropods before the close of the Jurassic. In addition, we conclude: (5)?The advent of avian unidirectional lung ventilation is not possible to pinpoint, as osteological correlates have yet to be identified for uni- or bidirectional lung ventilation. (6)?The origin and evolution of avian air sacs may have been driven by one or more of the following three factors: flow-through lung ventilation, locomotory balance, and/or thermal regulation. PMID:18825273

Sereno, Paul C.; Martinez, Ricardo N.; Wilson, Jeffrey A.; Varricchio, David J.; Alcober, Oscar A.; Larsson, Hans C. E.

2008-01-01

150

Social Cohesiveness, Territoriality, and Holiday DecorationsThe Influence of Cul-de-Sacs  

Microsoft Academic Search

Altman's territoriality theory was used as a framework for examining neighborhood attachment. We hypothesized that attachment would be manifested in interrelated patterns of neighboring behaviors, attitudes indicating that the block was a secondary territory, and individual and communal displays of holiday decorations. Design features of cul-de-sacs were hypothesized to contribute to greater degrees of block attachment on cul-de-sacs than on

Barbara B. Brown; Carol M. Werner

1985-01-01

151

Tonicity of human tear fluid sampled from the cul-de-sac  

Microsoft Academic Search

A 'freezing point' depression technique was used to determine the osmolality of 384 samples of tear fluid originating from the middle of the lower tear prism and the lower cul-de-sac of one eye of each of 12 young adults. Tear fluid from the cul-de-sac (mean 341.0 mosm\\/kg) was found overall to be significantly hypertonic (p less than 0.0001) relatively to

W J Benjamin; R M Hill

1989-01-01

152

Testosterone sensitivity of the seminal sacs of tree sparrows (Spizella arborea) in different reproductive states.  

PubMed

Testosterone sensitivity of the seminal sacs of castrated tree sparrows from each of three reproductive states was evaluated by measuring the change in seminal-sac mass per unit change in the logarithm of replacement or plasma testosterone. Birds were exposed to exogenous testosterone for 38 days. Replacement doses less than 0.17 mumol or plasma concentrations less than about 0.7 nmol/l did not induce seminal-sac growth in photosensitive castrated birds held on short days, in photosensitive castrated birds transferred from short to long days, or in photorefractory castrated birds retained on long days. Higher replacement doses or plasma concentrations, however, stimulated log dose-dependent growth of the seminal sacs in castrated birds from all three reproductive states. The change in seminal-sac mass per unit change in the logarithm of the dose of replacement testosterone was less (P = 0.0495) in photosensitive castrated birds held on short days than in photosensitive castrated birds transferred to long days. A more critical test of sensitivity (i.e. the change in seminal-sac mass per unit change in the logarithm of mean plasma testosterone concentration) indicated, however, that sensitivity of the seminal sacs to testosterone is independent of reproductive state. That result, when considered in the context of the plasma testosterone profile of intact males during a simulated reproductive cycle, argues that the seminal sacs of sexually quiescent (photosensitive or photorefractory) tree sparrows are small not because of their insensitivity to androgens, but because of a deficiency of circulating androgens. PMID:3701240

Wilson, F E

1986-04-01

153

An irreducible left scrotal hernia containing a sigmoid colon tumor (adenocarcinoma) – Case report  

PubMed Central

INTRODUCTION In relation to all inguinal hernias, large irreducible scrotal hernias are quite rare, while such hernias containing colon tumors in the sac have so far been described in fewer than 30 cases. PRESENTATION OF CASE A 61-year-old patient was admitted for a planned surgery because of a large irreducible left-sided scrotal hernia. Intraoperatively, a large tumor of the sigmoid colon was found in the hernial sac. In a histopathological examination it was diagnosed as adenocarcinoma. A palliative operation was performed and he was referred to further systemic and palliative treatment (because of numerous coexisting liver metastases). DISCUSSION Until now, only about 30 cases of colon tumor in inguinal hernia sac have been reported. CONCLUSION It should be remembered that even the most obvious preoperative diagnosis may be verified intraoperatively. PMID:24988210

Gna?, Jaros?aw; Bulsa, Marek; Czaja-Bulsa, Gra?yna

2014-01-01

154

Multiscale Modeling of the Effect of Micro-alloying Mn and Sb on the Viscoplastic Response of SAC105 Solder  

NASA Astrophysics Data System (ADS)

This study investigates the time-dependent viscoplastic response of two relatively new SAC105-X solders—SAC105-05Mn (Sn1.0Ag0.5Cu (SAC105) doped with 0.05 wt.% Mn), and SAC105-55Sb (SAC105 doped with 0.55 wt.% Sb). The results showed that the addition of Mn or Sb increases the creep resistance of SAC105 solder by one to two orders of magnitude at the tested stress levels of 2-20 MPa. The addition of Mn as a fourth alloying element promotes homogeneous distribution of micron-scale Cu6Sn5 intermetallic compounds (IMCs), thereby reducing their interparticle spacing as compared to that of SAC105. On the other hand, addition of Sb does not change the spacing of the Cu6Sn5 particle, but promotes the formation of uniformly sized Sn dendritic lobes, homogeneously distributed in the whole solder joint. Moreover, Sb also forms a solid solution with Sn and strengthens the Sn matrix in SAC105-55Sb itself. The effects of these microstructural changes (obtained using image processing) on the secondary creep constitutive response of SAC105 solder interconnects were then modeled using a mechanistic multiscale creep model. The mechanistic model was able to accurately capture the trends in the secondary creep constitutive response of the alloys and to explain the improvement in creep resistance of SAC105 due to the addition of Mn and Sb.

Mukherjee, Subhasis; Dasgupta, Abhijit; Zhou, Bite; Bieler, Thomas R.

2014-04-01

155

Established and potential physiological roles of bicarbonate-sensing soluble adenylyl cyclase (sAC) in aquatic animals.  

PubMed

Soluble adenylyl cyclase (sAC) is a recently recognized source of the signaling molecule cyclic AMP (cAMP) that is genetically and biochemically distinct from the classic G-protein-regulated transmembrane adenylyl cyclases (tmACs). Mammalian sAC is distributed throughout the cytoplasm and it may be present in the nucleus and inside mitochondria. sAC activity is directly stimulated by HCO3(-), and sAC has been confirmed to be a HCO3(-) sensor in a variety of mammalian cell types. In addition, sAC can functionally associate with carbonic anhydrases to act as a de facto sensor of pH and CO2. The two catalytic domains of sAC are related to HCO3(-)-regulated adenylyl cyclases from cyanobacteria, suggesting the cAMP pathway is an evolutionarily conserved mechanism for sensing CO2 levels and/or acid/base conditions. Reports of sAC in aquatic animals are still limited but are rapidly accumulating. In shark gills, sAC senses blood alkalosis and triggers compensatory H(+) absorption. In the intestine of bony fishes, sAC modulates NaCl and water absorption. And in sea urchin sperm, sAC may participate in the initiation of flagellar movement and in the acrosome reaction. Bioinformatics and RT-PCR results reveal that sAC orthologs are present in most animal phyla. This review summarizes the current knowledge on the physiological roles of sAC in aquatic animals and suggests additional functions in which sAC may be involved. PMID:24574382

Tresguerres, Martin; Barott, Katie L; Barron, Megan E; Roa, Jinae N

2014-03-01

156

Myoepithelial carcinoma arising in recurrent pleomorphic adenoma in maxillary sinus  

PubMed Central

Myoepithelial carcinoma is characterized by nearly exclusive myoepithelial differentiation and evidence of malignancy. It may arise de novo or in preexisting benign tumors including pleomorphic adenoma and benign myoepithelioma. A 39-year-old lady presented with painless progressive swelling on the right cheek and right side of palate. On surgery, there was a mass in right maxillary sinus which was surgically excised and diagnosed on histopathology as pleomorphic adenoma. Subsequently, there were two recurrences. The first recurrence was in the right maxilla after 2 years that was removed surgically and diagnosed as pleomorphic adenoma. One year later, she came with rapidly progressive swelling in bilateral cheeks and face. Intraoperatively, there was a large tumor in both maxillary sinuses with extensive local infiltration. Histologically, it was diagnosed as myoepithelial carcinoma. Carcinoma ex pleomorphic adenoma is usually a high grade malignancy. It occurs most commonly in parotid gland followed by submandibular glands, minor salivary glands and occasionally in sublingual gland. To the best of our knowledge, this is the first case of myoepithelial carcinoma arising in a recurrent pleomorphic adenoma in the maxillary sinus. PMID:24574666

Gupta, Ashumi; Manipadam, Marie Therese; Michael, Rajiv

2013-01-01

157

Adenocarcinoma arising from tubulovillous adenoma in a native bladder following gastrocystoplasty.  

PubMed

Gastrocystoplasty is a surgical form of bladder augmentation which improves bladder capacity and compliance. Patients who undergo bladder augmentation with a gastric remnant are at increased risk for malignancy. The most common types of tumors in this situation were adenocarcinoma and urothelial carcinoma. Most of the adenocarcinomas arise in the gastric remnant or anastomotic site, and adenocarcinomas arising in the residual native bladder are extremely rare. We report on a patient who received gastrocystoplasty 16 years ago. She suffered from recurrent urinary tract infections for a year and cystoscopy showed a tumor in the bladder trigone. Pathologic examination showed tubulovillous adenoma with malignant transformation to adenocarcinoma. The tumor consisted of intact adenomatous architecture from low-grade dysplastic gland to adenocarcinoma, which suggested that the pathogenesis might be related to intestinal metaplasia and dysplasia. The unique location and immunohistologic findings of the tumor suggested that it originated in the bladder mucosa. PMID:24030813

Lin, Ting-Po; Chen, Marcelo; Hsu, Jong-Ming; Sheu, J C

2014-01-01

158

Ultrastructure of the endolymphatic sac in the larva of the Japanese red-bellied newt Cynops pyrrhogaster  

Microsoft Academic Search

The ultrastructure of the endolymphatic sac (ES) of the late stage larva of the Japanese red-bellied newt, Cynops pyrrhogaster (stage 57), was examined by light and transmission electron microscopy. The two endolymphatic sacs are located at the dorsal-medial side of the otic vesicle on the dorsal-lateral side of the midbrain in the cranial cavity. The wall of the sac is

Wenyuan Gao; Michael Wiederhold; Robert Hejl

1998-01-01

159

Carcinoid tumor of the gall bladder  

Microsoft Academic Search

Carcinoid of the gall bladder and bile duct is a rare tumor. Primary gall bladder and billiard duct system carinoids constitute less than 1% of all carcinoid tumors arising from different parts of the body. We describe a case of carcinoid tumor of the gall bladder in a 53-year-old woman. The rarity of this entity prompted us to present our

Vasala Anjaneyulu; Gouri Shankar-Swarnalatha; Simhadri Chandra-Sekhar Rao

2007-01-01

160

A status report on the development of SAC2000: A new seismic analysis code  

SciTech Connect

We are developing a new Seismic Analysis Code (SAC2000) that will meet the research needs of the seismic research and treaty monitoring communities. Our first step in this development was to rewrite the original Seismic Analysis Code (SAC) -- a Fortran code that was approximately 140,000 lines long -- in the C programming language. This rewrite has resulted in a much more robust code that is faster, more efficient, and more portable than the original. We have implemented important processing capabilities such as convolution and binary monograms, and we have significantly enhanced several previously existing capabilities. For example, the spectrogram command now produces a correctly registered plot of the input time series and a color image of the output spectrogram. We have also added an image plotting capability with access to 17 predefined color tables or custom color tables. A rewritten version of the readcss command can now be used to access any of the documented css.3.0 database data formats, a capability that is particularly important to the Air Force Technical Applications Center (AFTAC) and the monitoring community. A much less visible, but extremely important contribution is the correction of numerous inconsistencies and errors that have evolved because of piecemeal development and limited maintenance since SAC was first written. We have also incorporated on-line documentation and have made SAC documentation available on the Internet via the world-wide-web at http://www-ep/tvp/sac.html.

Goldstein, P.; Minner, L.

1995-08-01

161

Sacs knockout mice present pathophysiological defects underlying autosomal recessive spastic ataxia of Charlevoix-Saguenay.  

PubMed

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS [MIM 270550]) is an early-onset neurodegenerative disorder caused by mutations in the SACS gene. Over 170 SACS mutations have been reported worldwide and are thought to cause loss of function of sacsin, a poorly characterized and massive 520 kDa protein. To establish an animal model and to examine the pathophysiological basis of ARSACS, we generated Sacs knockout (Sacs(-/-)) mice. Null animals displayed an abnormal gait with progressive motor, cerebellar and peripheral nerve dysfunctions highly reminiscent of ARSACS. These clinical features were accompanied by an early onset, progressive loss of cerebellar Purkinje cells followed by spinal motor neuron loss and peripheral neuropathy. Importantly, loss of sacsin function resulted in abnormal accumulation of non-phosphorylated neurofilament (NF) bundles in the somatodendritic regions of vulnerable neuronal populations, a phenotype also observed in an ARSACS brain. Moreover, motor neurons cultured from Sacs(-/-) embryos exhibited a similar NF rearrangement with significant reduction in mitochondrial motility and elongated mitochondria. The data points to alterations in the NF cytoskeleton and defects in mitochondrial dynamics as the underlying pathophysiological basis of ARSACS. PMID:25260547

Larivière, Roxanne; Gaudet, Rébecca; Gentil, Benoit J; Girard, Martine; Conte, Talita Cristiane; Minotti, Sandra; Leclerc-Desaulniers, Kim; Gehring, Kalle; McKinney, R Anne; Shoubridge, Eric A; McPherson, Peter S; Durham, Heather D; Brais, Bernard

2015-02-01

162

Prox1 expression in the endolymphatic sac revealed by whole-mount fluorescent imaging of Prox1-GFP transgenic mice.  

PubMed

This study describes a technical breakthrough in endolymphatic sac research, made possible by the use of the recently generated Prox1-GFP transgenic mouse model. Whole-mount imaging techniques through the decalcified temporal bone and three-dimensional observations of Prox1-GFP mouse tissue revealed the positive labeling of the endolymphatic sac in adult stage, and allowed, for the first time, the GFP-based identification of endolymphatic sac epithelial cells. Prox1 expression was observed in all parts of the endolymphatic sac epithelia. In intermediate portion of the endolymphatic sac, mitochondria-rich cells did not express Prox1, although ribosome-rich cells showed strong GFP labeling. The anatomical relationship between the endolymphatic sac and the surrounding vasculature was directly observed. In the endolymphatic sac, expression of Prox1 may suggest progenitor cell-like pluripotency or developmental similarity to systemic lymphatic vessels in other organs. This whole-mount imaging technique of the endolymphatic sac can be combined with other conventional histological, sectioning, and labeling techniques and will be very useful for future endolymphatic sac research. PMID:25529452

Miyashita, Takenori; Burford, James L; Hong, Young-Kwon; Gevorgyan, Haykanush; Lam, Lisa; Hoshikawa, Hiroshi; Mori, Nozomu; Peti-Peterdi, Janos

2015-01-30

163

Germ cell tumors in atypical locations: experience of the TGM 95 SFCE trial.  

PubMed

The yolk sac tumor is one of the most common malignant germ cell tumors in young children and typically occurs in the gonads. We report 6 cases of children less than 30 months old with extragonadal atypical locations of yolk sac tumor. These rare diagnoses were established by raised serum ?-fetoprotein levels and biopsies. These patients were treated according to the French TGM 95 trial. All the patients are alive disease-free after ?2.5 years of follow-up. We want to highlight the importance of measuring the ?-fetoprotein levels in very young children presenting with any midline tumor, even if the tumor is not located in the typical extragonadal sites such as the sacrococcyx, mediastinum, retroperitoneum, or vagina. PMID:24351970

Sudour-Bonnange, Hélène; Orbach, Daniel; Kalfa, Nicolas; Fasola, Sylvie; Patte, Catherine

2014-11-01

164

A New Technique for Reduction the Phase Induced Intensity Noise in SAC-OCDMA Systems  

NASA Astrophysics Data System (ADS)

A new code for reduction the phase induced intensity noise has been presented. The new code is proposed for Spectral Amplitude-Coding Optical Code Division Multiple Accesses (SAC-OCDMA). This new code family we call it Dynamic Cyclic Shift (DCS) code. The DCS code reduced the effect of Multi Access Interference (MAI) due to it is the property of variable cross correlation. We find that the performance of the DCS code is a batter than other SAC-OCDMA codes such as; Random Diagonal (RD) code, Modified Quadratic Congruence (MQC) code and Modified Frequency Hopping (MFH) code. Through the mathematical calculation and simulation analysis, for the bit-error rate of DCS code is significantly better than other SAC-OCDMA codes, the effect of Phase Induced Intensity Noise is reduced. In addition, proofof-principle simulations of 10 Gb/s for 20 km have been successfully demonstrated and achieved low BER compared to the other codes.

Abd, Thanaa Hussein; Aljunid, Syed Alwee; Fadhil, Hilal Adnan

2011-12-01

165

Successful treatment of hydatid cyst of lesser sac with PAIR therapy.  

PubMed

Hydatid disease has varied presentations and may involve any part of the body with hydatid disease of the liver being the most common site. Hydatid disease of lesser sac is a rare entity. Different treatment options of hydatid liver disease are available which include surgical, medical and radiological management. Surgical management has its limitations in terms of cost, morbidity, mortality, rate of recurrence and patient fitness to undergo surgery. Medical management alone carries a low chance of cure. Radiological management with PAIR therapy (percutaneous aspiration, injection and re-aspiration) of hydatid liver disease has been well described in literature. However, hydatid disease of lesser sac in itself is a rare entity and its treatment with PAIR procedure has not been described before. We describe a case of hydatid disease of lesser sac treated with the PAIR procedure. PMID:24304995

Fayyaz, Afshan; Ghani, Umar Fayyaz

2013-12-01

166

Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors  

ClinicalTrials.gov

Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Childhood Choroid Plexus Tumor; Childhood Craniopharyngioma; Childhood Ependymoblastoma; Childhood Grade I Meningioma; Childhood Grade II Meningioma; Childhood Grade III Meningioma; Childhood High-grade Cerebellar Astrocytoma; Childhood High-grade Cerebral Astrocytoma; Childhood Infratentorial Ependymoma; Childhood Low-grade Cerebellar Astrocytoma; Childhood Low-grade Cerebral Astrocytoma; Childhood Medulloepithelioma; Childhood Mixed Glioma; Childhood Oligodendroglioma; Childhood Supratentorial Ependymoma; Extra-adrenal Paraganglioma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Spinal Cord Neoplasm; Recurrent Childhood Subependymal Giant Cell Astrocytoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Childhood Visual Pathway and Hypothalamic Glioma

2013-05-01

167

sAC as a model for understanding the impact of endosymbiosis on cell signaling.  

PubMed

As signaling pathways evolve, selection for new functions guides the co-option of existing material. Major transitions in the history of life, including the evolution of eukaryotes and multicellularity, exemplify this process. These transitions provided both strong selection and a plenitude of available material for the evolution of signaling pathways. Mechanisms that evolved to mediate conflict during the evolution of eukaryotes may subsequently have been co-opted during the many independent derivations of multicellularity. The soluble adenylyl cyclase (sAC) signaling pathway illustrates this hypothesis. Class III adenylyl cyclases, which include sAC, are found in bacteria, including the ?-proteobacteria. These adenylyl cyclases are the only ones present in eukaryotes but appear to be absent in archaeans. This pattern suggests that the mitochondrial endosymbiosis brought sAC signaling to eukaryotes as part of an intact module. After transfer to the proto-nuclear genome, this module was then co-opted into numerous new functions. In the evolution of eukaryotes, sAC signaling may have mediated conflicts by maintaining metabolic homeostasis. In the evolution of multicellularity, in different lineages sAC may have been co-opted into parallel tasks originally related to conflict mediation. Elucidating the history of the sAC pathway may be relatively straightforward because it is ubiquitous and linked to near universal metabolic by-products (CO2/HCO3(-)). Other signaling pathways (e.g., those involving STAT and VEGF) present a greater challenge but may suggest a complementary pattern. The impact of the mitochondrial endosymbiosis on cell signaling may thus have been profound. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease. PMID:24907565

Blackstone, Neil W

2014-12-01

168

Primitive Neuroectodermal Kidney Tumor: 2 Case Reports and Review of the Literature  

Microsoft Academic Search

Peripheral neuroectodermal tumors are uncommon cancers arising from outside the central nervous system. The urinary system is rarely involved. The differentiation of these tumors from other small cell cancer and neuroblastoma is based on immunohistochemical differences. We report 2 cases of such tumors arising from the renal parenchyma. Tumor behavior and treatment modalities are discussed.

Narmada P. Gupta; Barinder Pal Singh; V. Raina; S. Datta Gupta

1995-01-01

169

Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti  

PubMed Central

Here we describe preparatory techniques adapted for the study of proteins of inner ear tissues and fluids that have allowed us to apply state-of-the-art analytical techniques in spite of the minute size and anatomical complexities of this organ. Illustrative examples address unresolved issues of functional and clinical significance. First, we demonstrate how quick-freezing and freeze drying prevents artifacts that arise from sampling endolymphatic sac (ES) content in the liquid state. This set the stage for the generation of the first protein profile of the ES. Identification of crucial proteins will help elucidate mechanisms of endolymph volume regulation and pathogenesis of Meniere’s disease. Second, we show how a unique situation allowed identification of otoconial proteins by mass spectrometric analysis without prior separation and we discuss possible roles for these minor otoconins in otoconial development and prevention of degenerative diseases that affect balance. Finally, we demonstrate techniques for the precise dissection of organ of Corti and its substructures, while preserving their near normal chemical state. We extended an earlier study in which we identified a novel calcium-binding protein by IEF, oncomodulin, localized in the outer hair cells and show here the applicability of prefractionation for the screening of calcium-binding proteins of organ of Corti. These studies demonstrate how advanced preparatory and analytical techniques can be applied to studies of the inner ear. PMID:16609936

Thalmann, Isolde; Hughes, Inna; Tong, Benton D.; Ornitz, David M.; Thalmann, Ruediger

2007-01-01

170

Primary yolk sac tumour of the urinary bladder: A case report and review of the literature  

PubMed Central

We present a case of rare primary yolk sac tumour of the urinary bladder in adulthood. A 31-year-old female patient presented with a history of chronic ketamine abuse, which has not previously been shown to be associated with malignancy development. The final diagnosis was established only after radical cystectomy. A computed tomography (CT) scan showed paraaortic lymph node metastasis. The patient was treated with systemic chemotherapy. A review of the literature revealed that surgical excision and cisplatin-based chemotherapy remain to be the standard of care for extragonadal yolk sac tumours. PMID:24348848

MUI, WING HO; LEE, KA CHAI; CHIU, SIN CHUEN; PANG, CHUN YIN; CHU, SAU KWAN; MAN, CHI WAI; WONG, CHI SING; SZE, WING KIN; TUNG, YUK

2014-01-01

171

Experimental demonstration of variable weight SAC-OCDMA system for QoS differentiation  

NASA Astrophysics Data System (ADS)

In this paper the experimental and simulation results of variable-weight spectral amplitude coding optical code division multiple access (VW-SAC-OCDMA) system is demonstrated. In the proposed system, three users with weights of 6, 4 and 2 each operating at data rate of 1.25 Gb/s represent video, data and voice services, respectively. Results show that for back-to-back system minimum average power of -20 dBm per chip is required to maintain the acceptable performance. Transmission up to 60 km of fiber is demonstrated. Using mathematical approximation the capacity of VW-SAC-OCDMA system is demonstrated.

Seyedzadeh, Saleh; Mahdiraji, Ghafour Amouzad; Sahbudin, Ratna Kalos Zakiah; Abas, Ahmad Fauzi; Anas, Siti Barirah Ahmad

2014-10-01

172

Tumeur du sac vitellin du testicule au stade IIIc métastatique : à propos d’un cas  

PubMed Central

Résumé Les tumeurs du sac vitellin du testicule sont rares chez l’adulte. Ces tumeurs se caractérisent par un mauvais pronostic à un stade métastatique avancé. Cependant, nous rapportons, dans le présent article, le cas clinique d’un adulte de 32 ans qui présentait une tumeur du sac vitellin du testicule au stade IIIc métastatique. Ce patient a subi une orchidectomie haute, accompagnée de quatre cycles de chimiothérapie à base de bléomycine, d’étoposide et de cisplatine. Il a répondu complètement au traitement, moyennant un recul de deux ans. PMID:25295144

Zizi, Mohamed; Ziouziou, Imad; El Yacoubi, Souhail; Khmou, Mouna; Jahid, Ahmed; Mahassini, Najat; Karmouni, Tariq; El Khader, Khalid; Koutani, Abdellatif; Andaloussi, Ahmed Iben Attya

2014-01-01

173

Postcranial skeletal pneumaticity and air-sacs in the earliest pterosaurs  

PubMed Central

Patterns of postcranial skeletal pneumatization (PSP) indicate that pterosaurs possessed components of a bird-like respiratory system, including a series of ventilatory air-sacs. However, the presence of PSP in the oldest known pterosaurs has not been unambiguously demonstrated by previous studies. Here we provide the first unequivocal documentation of PSP in Late Triassic and earliest Jurassic pterosaurs. This demonstrates that PSP and, by inference, air-sacs were probably present in the common ancestor of almost all known pterosaurs, and has broader implications for the evolution of respiratory systems in bird-line archosaurs, including dinosaurs. PMID:19411265

Butler, Richard J.; Barrett, Paul M.; Gower, David J.

2009-01-01

174

A case of clear cell adenocarcinoma arising from endometriosis of the rectum treated by laparoscopic surgery  

PubMed Central

INTRODUCTION Malignant transformation of intestinal endometriosis occurring in the extraovarian sites is extremely rare. We report a very rare case of clear cell adenocarcinoma arising from endometriosis of the rectum. PRESENTATION OF CASE An 83-year-old woman was admitted with the complaint of hematochezia. Colonoscopy revealed a tumor around about half of the rectal circumference. Biopsy of the tumor revealed a well-differentiated adenocarcinoma. Low anterior resection was undergone laparoscopically under the diagnosis of rectal carcinoma. Histopathological examination revealed clear cell adenocarcinoma, invading the sub-serosa of the rectum, but no metastasis of the lymph nodes. Immunohistochemical staining showed strong positivity for cytokeratin 7, but no staining for cytokeratin 20 and CDX2. The tumor existed adjacent to the endometrial glands, which were stained positive for Estrogen receptor. Ultimately, the patient was diagnosed with clear cell adenocarcinoma arising from endometriosis. Eighteen months after surgery, there are no signs of tumor recurrence. DISCUSSION Clear cell adenocarcinoma arising from intestinal endometriosis has been reported in 7 cases, including our case. Careful observation is required because the prognosis of endometriosis after malignant transformation remains poor. CONCLUSION We report a very rare case of clear cell adenocarcinoma arising from endometriosis of the rectum treated by laparoscopic surgery. PMID:25460452

Okazawa, Yu; Takahashi, Rina; Mizukoshi, Kosuke; Takehara, Kazuhiro; Ishiyama, Shun; Sugimoto, Kiichi; Takahashi, Makoto; Kojima, Yutaka; Goto, Michitoshi; Okuzawa, Atsushi; Tomiki, Yuichi; Yao, Takashi; Sakamoto, Kazuhiro

2014-01-01

175

32 CFR 536.112 - Settlement authority for claims arising under international agreements (for those claims arising...  

Code of Federal Regulations, 2010 CFR

...arising under international agreements (for those claims arising...Cognizable Under International Agreements § 536.112 Settlement...arising under international agreements (for those claims arising...objection. See, for example, NATO SOFA, Article...

2010-07-01

176

INCIDENCE AND SIZE DISTRIBUTION OF UNABSORBED YOLK SACS IN COMMERCIAL BROILERS PROCESSED AT SIX WEEKS OF AGE  

Technology Transfer Automated Retrieval System (TEKTRAN)

Unabsorbed yolk sacs are being investigated as a possible vehicle for vertical transmission of Campylobacter and salmonellae from broiler breeder hens to broilers. However, it is unknown at what frequency unabsorbed yolk sacs exist in present day commercial broilers at the time of processing. Two ...

177

Endometrial carcinoma arising in a bicornuate uterus  

PubMed Central

Endometrial carcinomas arising in a bicornuate uterus are rare, only five case of which have been previously reported. We present a case of endometrial cancer arising in a bicornuate uterus, occurring in a 65-year-old woman. Unlike previously reported cases, our case showed mixed endometrial adenocarcinoma and undifferentiated carcinoma in one horn and focal adenocarcinoma in the other. Adequate tissue sampling of both horns is necessary for accurate diagnosis of malignancy in patients with a bicornuate uterus. Physicians should be aware of the possibility of this abnormality in cases when endometrial cancer is suspected but histology fails to confirm. PMID:25264532

Munkhdelger, Jijgee; Mia-Jan, Khalilullah; Cha, Dong Soo

2014-01-01

178

The corn snake yolk sac becomes a solid tissue filled with blood vessels and yolk-rich endodermal cells  

PubMed Central

The amniote egg was a key innovation in vertebrate evolution because it supports an independent existence in terrestrial environments. The egg is provisioned with yolk, and development depends on the yolk sac for the mobilization of nutrients. We have examined the yolk sac of the corn snake Pantherophis guttatus by the dissection of living eggs. In contrast to the familiar fluid-filled sac of birds, the corn snake yolk sac invades the yolk mass to become a solid tissue. There is extensive proliferation of yolk-filled endodermal cells, which associate with a meshwork of blood vessels. These novel attributes of the yolk sac of corn snakes compared with birds suggest new pathways for the evolution of the amniote egg. PMID:24402715

Elinson, Richard P.; Stewart, James R.

2014-01-01

179

Therapeutic effect of dienogest on adenosarcoma arising from endometriosis: a case report.  

PubMed

Dienogest is a novel synthesized progestin used for treatment of endometriosis. This is the first case report describing a therapeutic effect of dienogest on a gynecologic malignancy. The patient was a 44-year-old woman with advanced adenosarcoma arising from the endometriosis in the rectovaginal space and infiltrating the left pelvic wall, left ureter, rectum and vagina. The residual tumor after tumor debulking surgery was resistant to both chemotherapy and radiotherapy. Dienogest was used as a substitute for medroxyprogesterone acetate because of the presence of deep vein thrombosis. Based on the RECIST criteria, partial response was obtained with oral dienogest therapy at six months and the serum CA125 level also decreased from 70 U/ml to 16 U/ml. The tumor remained stable up to 21 months. Thromboembolism or other adverse effects did not occur during the dienogest therapy. Dienogest may be useful for the treatment of adenosarcoma arising from endometriosis. PMID:24324925

Tasaka, Nobutaka; Matsumoto, Koji; Satoh, Toyomi; Minaguchi, Takeo; Onuki, Mamiko; Ochi, Hiroyuki; Tanaka, Yumiko O; Sakata, Akiko; Noguchi, Masayuki; Yoshikawa, Hiroyuki

2013-01-01

180

ARISE: American renaissance in science education  

SciTech Connect

The national standards and state derivatives must be reinforced by models of curricular reform. In this paper, ARISE presents one model based on a set of principles--coherence, integration of the sciences, movement from concrete ideas to abstract ones, inquiry, connection and application, sequencing that is responsive to how people learn.

NONE

1998-09-14

181

Very ample configurations arising from contingency tables  

E-print Network

In this paper, it is proved that, if a toric ideal possesses a fundamental binomial none of whose monomials is squarefree, then the corresponding semigroup ring is not very ample. Moreover, very ample semigroup rings of Lawrence type are discussed. As an application, we study very ampleness of configurations arising from contingency tables.

Ohsugi, Hidefumi

2009-01-01

182

Imaging and clinical findings in large endolymphatic duct and sac syndrome  

Microsoft Academic Search

ObjectiveLarge endolymphatic duct and sac syndrome (LEDS) is known as the most common kind of inner ear malformations, which is radiologically detectable. Nevertheless, nowadays many questions are not fully cleared and LEDS is relatively unknown among general radiologists. The aim of this study was to evaluate the incidence of LEDS in the own patient population and to present our experiences

Sabrina Koesling; Christine Rasinski; Beatrice Amaya

2006-01-01

183

A Cross-Ethnic Validity Study of the Shortform Assessment for Children (SAC)  

ERIC Educational Resources Information Center

Objective: This study examined the cross-ethnic measurement equivalence of the Shortform Assessment for Children (SAC) using a sample of 562 African American and 692 White children. Method: A prospective, two-panel survey design was used in this study. Baseline and 6-month follow-up data were used to conduct analyses of the reliability and…

Tyson, Edgar H.; Glisson, Charles

2005-01-01

184

Faraday Discuss. Chem. Sac., 1983, 76,65-75 Electrical Double-layer Interactions in  

E-print Network

Faraday Discuss. Chem. Sac., 1983, 76,65-75 Electrical Double-layer Interactions in Concentrated In this paper we compare three methods for deducing the effective pair potential that describes the double-layer that the electrostatic or electrical double-layer interactions between colloidal particles are responsible for giving

Chan, Derek Y C

185

Defective histone supply causes condensin-dependent chromatin alterations, SAC activation and chromosome decatenation impairment  

PubMed Central

The structural organization of chromosomes is essential for their correct function and dynamics during the cell cycle. The assembly of DNA into chromatin provides the substrate for topoisomerases and condensins, which introduce the different levels of superhelical torsion required for DNA metabolism. In particular, Top2 and condensin are directly involved in both the resolution of precatenanes that form during replication and the formation of the intramolecular loop that detects tension at the centromeric chromatin during chromosome biorientation. Here we show that histone depletion activates the spindle assembly checkpoint (SAC) and impairs sister chromatid decatenation, leading to chromosome mis-segregation and lethality in the absence of the SAC. We demonstrate that histone depletion impairs chromosome biorientation and activates the Aurora-dependent pathway, which detects tension problems at the kinetochore. Interestingly, SAC activation is suppressed by the absence of Top2 and Smc2, an essential component of condensin. Indeed, smc2-8 suppresses catenanes accumulation, mitotic arrest and growth defects induced by histone depletion at semi-permissive temperature. Remarkably, SAC activation by histone depletion is associated with condensin-mediated alterations of the centromeric chromatin. Therefore, our results reveal the importance of a precise interplay between histone supply and condensin/Top2 for pericentric chromatin structure, precatenanes resolution and centromere biorientation. PMID:25300489

Murillo-Pineda, Marina; Cabello-Lobato, María J.; Clemente-Ruiz, Marta; Monje-Casas, Fernando; Prado, Félix

2014-01-01

186

First Description of Egg Sacs and Early Larval Development in Hynobiid Salamanders (Urodela, Hynobiidae, Batrachuperus)  

E-print Network

First Description of Egg Sacs and Early Larval Development in Hynobiid Salamanders (Urodela embryonic development of an Iranian hynobiid salamander (the Eastern nominal taxon, Batrachuperus gor Corridor (= Hyrcania) of Northern Iran. The corridor is a "unique relict biogeo- graphic area," which

Alvarez, Nadir

187

Primacy and Recency as Factors in Cul-de-Sac Elimination in a Stylus Maze  

Microsoft Academic Search

For this experiment a form of maze was used which was sufficiently difficult for the human subject and involved only a single type of cul-de-sac. Two patterns of the maze were constructed, the only difference in the two being that one was a lateral reversal of the other. Sixty subjects took part in the experiment. The results support the view,

C. J. Warden

1924-01-01

188

From Performance Management to Capacity-Building: An Escape from the "Cul De Sac"?  

ERIC Educational Resources Information Center

This article examines the many critiques of educational policies concerning the National Curriculum and the standards and testing regimes for pupils and teachers associated with it. It goes on to suggest that there is a danger of educational researchers and policy-makers arguing themselves into a "cul de sac" where an unproductive stand-off may…

Storey, Anne

2004-01-01

189

The South China Sea, a cul-de-sac of North Pacific Intermediate Water  

Microsoft Academic Search

This study discusses branching of the Kuroshio Current including North Pacific Intermediate Water (NPIW) into the South China Sea (SCS). The spreading path of the subtropical salinity minimum of NPIW is southwestward pointing to the Luzon Strait between Taiwan and Luzon islands. Using a large collection of updated hydrography, results show that the SCS is a cul-de-sac for the subtropical

Yuzhu You; Ching-Sheng Chern; Yih Yang; Cho-Teng Liu; Kon-Kee Liu; Su-Cheng Pai

2005-01-01

190

Conformational dependence of the circular dichroism spectrum of ?-hydroxyphenylacetic acid: a ChiraSac study.  

PubMed

The conformational dependence of the circular dichroism (CD) spectrum of a chiral molecule, ?-hydroxyphenylacetic acid (HPAA) containing phenyl, COOH, OH and H groups around a chiral carbon atom, has been studied theoretically by using the SAC-CI (symmetry adapted cluster-configuration interaction) theory. The results showed that the CD spectrum of HPAA depends largely on the rotations (conformations) of the phenyl and COOH groups around the single bonds. The first band is due to the excitation of electrons belonging to the phenyl region and therefore sensitive to the phenyl rotation. The second band is due to the excitation of electrons belonging to the COOH region and therefore sensitive to the COOH rotation. From the comparison of the SAC-CI CD spectra calculated at various conformations of phenyl, COOH, and OH groups with the experimental spectrum, we could predict the stable geometry of this molecule, which agreed well with the most stable conformation deduced from the energy criterion. We also calculated the Boltzmann averaged spectrum and obtained better agreement with the experiment. Further, we performed preliminary investigations of the temperature dependence of the CD spectrum of HPAA. In general, the CD spectra of chiral molecules are very sensitive to low-energy processes like the rotations around the single bonds. Therefore, one should be able to study the natures of the weak interactions by comparing the SAC-CI spectra calculated at different geometries and conditions with the experimental spectrum using a new methodology we have termed ChiraSac. PMID:24256101

Miyahara, Tomoo; Nakatsuji, Hiroshi

2013-12-27

191

Self-Assembly of Large and Small Molecules into Hierarchically Ordered Sacs and Membranes  

Microsoft Academic Search

We report here the self-assembly of macroscopic sacs and membranes at the interface between two aqueous solutions, one containing a megadalton polymer and the other, small self-assembling molecules bearing opposite charge. The resulting structures have a highly ordered architecture in which nanofiber bundles align and reorient by nearly 90° as the membrane grows. The formation of a diffusion barrier upon

Ramille M. Capito; Helena S. Azevedo; Yuri S. Velichko; Alvaro Mata; Samuel I. Stupp

2008-01-01

192

13th SAC ISTC Seminar "New Perspectives of High Energy Physics"  

E-print Network

13th SAC ISTC Seminar "New Perspectives of High Energy Physics" Novosibirsk 1-5 September 2010 V. Myalkovskiy, JINR, Dubna, Russia on behalf of the ATLAS TRT Collaboration DESIGN AND CONSTRUCTION OF THE ATLAS TRANSITION RADIATION TRACKER #12;V.Myalkovskiy 13th

193

An observing system simulation experiment (OSSE) for the aquarius/SAC-D soil moisture product  

Technology Transfer Automated Retrieval System (TEKTRAN)

An Observing System Simulation Experiment for the Aquarius/SAC-D mission has been developed for assessing the accuracy of soil moisture retrievals from passive L-band remote sensing. The implementation of the OSSE is based on: a 1-km land surface model over the Red-Arkansas River Basin, a forward mi...

194

A revision of the endemic South African sac spider genus Lessertina Lawrence, 1942 (Araneae: Eutichuridae).  

PubMed

The endemic South African sac spider genus Lessertina Lawrence, 1942, previously known only from the type species (L. mutica Lawrence, 1942), is revised. Both sexes of L. mutica are redescribed and the species is recorded from the Eastern Cape, KwaZulu-Natal and Limpopo Provinces. A new species, L. capensis sp. nov., is described from the Eastern and Western Cape Provinces. PMID:25544208

Haddad, Charles R

2014-01-01

195

Cells of the connective tissue differentiate and migrate into pollen sacs  

NASA Astrophysics Data System (ADS)

In angiosperms, archesporial cells in the anther primordium undergo meiosis to form haploid pollen, the sole occupants of anther sacs. Anther sacs are held together by a matrix of parenchyma cells, the connective tissue. Cells of the connective tissue are not known to differentiate. We report the differentiation of parenchyma cells in the connective tissue of two Gordonia species into pollen-like structures (described as pseudopollen), which migrate into the anther sacs before dehiscence. Pollen and pseudopollen were distinguishable by morphology and staining. Pollen were tricolpate to spherical while pseudopollen were less rigid and transparent with a ribbed surface. Both types were different in size, shape, staining and surface architecture. The ratio of the number of pseudopollen to pollen was 1:3. During ontogeny in the connective tissue, neither cell division nor tetrad formation was observed and hence pseudopollen were presumed to be diploid. Only normal pollen germinated on a germination medium. Fixed preparations in time seemed to indicate that pseudopollen migrate from the connective tissue into the anther sac.

Iqbal, M. C. M.; Wijesekara, Kolitha B.

2002-01-01

196

SAC 2005 -Santa Fe Sanitizing using Metadata in MetaXQuery  

E-print Network

SAC 2005 - Santa Fe Sanitizing using Metadata in MetaXQuery Hao Jin and Curtis Dyreson School of E.E. and Computer Science Washington State University USA Sanitizing using Metadata in MetaXQuery - Jin and Dyreson Outline · XQuery · Metadata · Sanitize · Experiments · Summary Sanitizing using Metadata in Meta

Dyreson, Curtis

197

Ventilation patterns of the songbird lung/air sac system during different behaviors.  

PubMed

Unidirectional, continuous airflow through the avian lung is achieved through an elaborate air sac system with a sequential, posterior to anterior ventilation pattern. This classical model was established through various approaches spanning passively ventilated systems to mass spectrometry analysis of tracer gas flow into various air sacs during spontaneous breathing in restrained ducks. Information on flow patterns in other bird taxa is missing, and these techniques do not permit direct tests of whether the basic flow pattern can change during different behaviors. Here we use thermistors implanted into various locations of the respiratory system to detect small pulses of tracer gas (helium) to reconstruct airflow patterns in quietly breathing and behaving (calling, wing flapping) songbirds (zebra finch and yellow-headed blackbird). The results illustrate that the basic pattern of airflow in these two species is largely consistent with the model. However, two notable differences emerged. First, some tracer gas arrived in the anterior set of air sacs during the inspiration during which it was inhaled, suggesting a more rapid throughput through the lung than previously assumed. Second, differences in ventilation between the two anterior air sacs emerged during calling and wing flapping, indicating that adjustments in the flow pattern occur during dynamic behaviors. It is unclear whether this modulation in ventilation pattern is passive or active. This technique for studying ventilation patterns during dynamic behaviors proves useful for establishing detailed timing of airflow and modulation of ventilation in the avian respiratory system. PMID:23788706

Mackelprang, Rebecca; Goller, Franz

2013-10-01

198

Probabilistic Basis for 2000 SAC Federal Emergency Management Agency Steel Moment Frame Guidelines  

Microsoft Academic Search

This paper presents a formal probabilistic framework for seismic design and assessment of structures and its application to steel moment-resisting frame buildings. This is the probabilistic basis for the 2000 SAC Federal Emergency Management Agency ~FEMA! steel moment frame guidelines. The framework is based on realizing a performance objective expressed as the probability of exceeding a specified performance level. Performance

C. Allin Cornell; Fatemeh Jalayer; Ronald O. Hamburger; Douglas A. Foutch

2002-01-01

199

Bat serenades—complex courtship songs of the sac-winged bat ( Saccopteryx bilineata )  

Microsoft Academic Search

Vocalisations of many songbirds, anurans, and insects are shaped by sexual selection. Males acoustically compete for territories, and females choose their mates by means of male courtship songs. In courtship, richness and complexity of elements are often favoured characters. Only a few examples of complex songs are known in mammals. Males of the harem-polygynous sac-winged bat ( Saccopteryx bilineata, Emballonuridae)

Oliver Behr; Otto von Helversen

2004-01-01

200

2 CFR Appendix X to Part 200 - Data Collection Form (Form SF-SAC)  

...2014-01-01 false Data Collection Form (Form SF-SAC) X Appendix X to Part 200 Grants and Agreements Office of Management...AUDIT REQUIREMENTS FOR FEDERAL AWARDS Pt. 200, App. X Appendix X to Part 200—Data Collection Form (Form...

2014-01-01

201

[Omental hernia through esophageal hiatus simulates mediastinal lipomatous tumor].  

PubMed

Omental hernia through the esophageal hiatus is extemely infrequent. Paraesophageal hiatal hernia with omentum in the herniary sac mimics a mediastinal lipomatous tumor and differential diagnosis should be made. This diagnosis requires experience and knowledge of the differences between these two pathologies. In the following study we describe the case of an omental hernia and the characteristics that make it different from other pathologies. PMID:24847629

Saleg, Patricia; Maldonado, Pablo; Alcaraz, Alvaro; Moser, Federico; Peralta, Laura; Obeide, Lucio

2014-03-01

202

The Probabilistic Basis for the 2000 SAC/FEMA Steel Moment Frame C. Allin Cornell 1 , Member, ASCE, Fatemeh Jalayer 2 , Ronald O. Hamburger 3 , Member,  

E-print Network

The Probabilistic Basis for the 2000 SAC/FEMA Steel Moment Frame Guidelines C. Allin Cornell 1 for the 2000 SAC/FEMA steel moment frame guidelines. The framework is based on realizing a performance of the performance objective being met. This format has been adopted in the SAC/FEMA guidelines. Keywords

Sweetman, Bert

203

Combining anti-cancer drugs with artificial sweeteners: synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2].  

PubMed

The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac=saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac=thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2] x H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity. PMID:25216367

Al-Jibori, Subhi A; Al-Jibori, Ghassan H; Al-Hayaly, Lamaan J; Wagner, Christoph; Schmidt, Harry; Timur, Suna; Baris Barlas, F; Subasi, Elif; Ghosh, Shishir; Hogarth, Graeme

2014-12-01

204

Sac-1004, a novel vascular leakage blocker, enhances endothelial barrier through the cAMP/Rac/cortactin pathway.  

PubMed

The maintenance of endothelial barrier is critical for the vascular homeostasis and is maintained by the interaction of adherens junction (AJ) and tight junction (TJ) proteins between adjacent cells. This interaction is stabilized by actin cytoskeleton forming cortical actin ring. Here, we developed a novel vascular leakage blocker, Sac-1004 and investigated its mechanism of action in endothelial cells (ECs). Sac-1004 inhibited endothelial hyperpermeability induced by vascular endothelial growth factor, histamine and thrombin via stabilization of cortical actin ring and AJ proteins at the cell-cell junction. Treatment of Sac-1004 in ECs increased cAMP levels and activated Rac, both of which are known to strengthen endothelial barrier. Furthermore, Sac-1004 induced phosphorylation of cortactin and its localization at cell membrane that is essential for the stabilization of cortical actin ring. These effects of Sac-1004 on ECs were significantly abrogated by dideoxyadenosine (adenylyl cyclase inhibitor) and NSC23766 (Rac inhibitor). Taken together, our findings indicate that Sac-1004 blocks vascular leakage by enhancing endothelial integrity via the cAMP/Rac/cortactin pathway and imply the potential usefulness of Sac-1004 in the development of therapeutic means for vascular leakage-related diseases. PMID:23665326

Maharjan, Sony; Kim, Kyeojin; Agrawal, Vijayendra; Choi, Hyun-Jung; Kim, Nam-Jung; Kim, Young-Myeong; Suh, Young-Ger; Kwon, Young-Guen

2013-06-01

205

Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus.  

PubMed

A 54-year-old man presented with a recurrent swelling on the right occipital region of the scalp. Two months earlier, the patient had undergone an initial local excision of the lesion which had enlarged progressively over the previous 2 years on a hairless patch which had been present since birth. On examination, a 5 x 4-cm, pinkish, firm, ulcerated swelling was seen on the right occipital region with a scar running over it. The lesion was not fixed to the underlying bone and there was no regional lymphadenopathy. X-Ray of the skull was normal and no evidence of metastatic disease was identified. Wide local excision of the tumor was performed and it was sent for histopathologic examination. Specimens and slides of the earlier surgery performed elsewhere were also studied. The specimen of the initial surgery consisted of skin-covered tissue with an exophytic firm growth measuring 6 x 5 x 4 cm. The skin surface was rough with areas of ulceration. No necrosis was noted grossly. Microscopically, three distinct lesions were seen. One was a well-circumscribed tumor located in the superficial dermis with lobules of basaloid cell aggregates with peripheral palisading and with no epidermal connection. The lobules were surrounded by cellular fibrous tissue (Fig. 1). Unlike basal cell carcinoma, however, no cleft between the cellular aggregates and stroma was noted. Foci of pigmentation were seen within cellular lobules and these features were consistent with a diagnosis of tricho-blastoma. The second tumor was seen adjacent to the first, and consisted of duct-like structures and cystic spaces with papillary projections. These were lined by double-layered epithelium with stromal infiltration by plasma cells, which are features of syringocystadenoma papilliferum (Fig. 2). The third lesion was a spindle cell sarcoma which formed the major part of the lesion, diffusely infiltrating the dermis and subcutaneous tissue, elevating and ulcerating the overlying skin. The tumor consisted of interlacing fascicles of spindle cells with oval to elongated nuclei having finely dispersed chromatin and inconspicuous nucleoli. The tumor cells were seen encircling the sweat glands, without destroying them (Fig. 3). Nuclear pleomorphism was minimal, with a mitotic rate of 9-10 per high-power field. A small area of epidermal hyperplasia with acanthosis and papillomatosis overlying malformed highly placed sebaceous glands was the only evidence of a pre-existing nevus sebaceus. The status of the surgical margins was not clearly discernible. The wide excision specimen of the recurrent swelling consisted of a skin-covered nodule with ulceration, measuring 3 x 4 x 3 cm, with a gray-white whorled cut surface. No necrosis was noted grossly. Multiple sections showed only spindle cell sarcoma infiltrating the skin and subcutaneous tissue, morphologically similar to the earlier tumor, with ulceration of the overlying skin. The surgical margins were free from tumor. Immunohistochemical stains on the spindle cell sarcoma showed positive staining for smooth muscle actin (SMA) (Fig. 4), vimentin, epithelial membrane antigen (EMA), and S100. The tumor cells were negative for cytokeratin (CK), HMB45, desmin, glial fibrillary acidic protein (GFAP), CD34, and CD68. Correlating the histomorphology and immunohistochemical findings, a diagnosis of cutaneous leiomyosarcoma with tricho-blastoma and syringocystadenoma papilliferum arising on nevus sebaceus was made. The patient received postoperative radiotherapy and is disease free 8 months after diagnosis. PMID:17343592

Premalata, C S; Kumar, Rekha V; Malathi, M; Shenoy, A M; Nanjundappa, N

2007-03-01

206

Rhabdoid Tumor Predisposition Syndrome.  

PubMed

Abstract Rhabdoid tumors (RT), or malignant rhabdoid tumors (MRT), are amongst the most aggressive and lethal forms of human cancer. They can arise in any location in the body but are most commonly observed in the brain, where they are called atypical teratoid / rhabdoid tumors (AT/RT), and in the kidneys, where they are called rhabdoid tumors of the kidney (RTK). The vast majority of rhabdoid tumors present with a loss of function in the SMARCB1 gene, also known as INI1, BAF47 and hSNF5,, a core member of the SWI/SNF chromatin-remodeling complex. Recently, mutations in a second locus of the SWI/SNF complex, the SMARCA4 gene, also known as BRG1 were found in rhabdoid tumors with retention of SMARCB1 expression. Familial cases may occur in a condition known as rhabdoid tumor predisposition syndrome (RTPS). In RTPS, germline inactivation of one allele of a gene occurs. When the mutation occurs in the SMARCB1 gene, the syndrome is called RTPS1, and when the mutation occurs in the SMARCA4, gene it is called RTPS2. Children presenting with RTPS tend to develop tumors at a younger age, but the impact that germline mutation has on survival remains unclear. Adults who carry the mutation tend to develop multiple schwannomas. The diagnosis of RTPS should be considered in patients with RT, especially if they have multiple primary tumors and/or in individuals with a family history of RT. Because germline mutations result in an increased risk of carriers developing RT, genetic counseling for families with this condition is recommended. PMID:25494491

Sredni, Simone Treiger; Tomita, Tadanori

2014-12-10

207

Localization of Bacillus subtilis sacU(Hy) mutations to two linked genes with similarities to the conserved procaryotic family of two-component signalling systems.  

PubMed Central

Mutations in the sacU region have a pleiotropic phenotype. Certain mutations designated sacU(Hy), for example, express degradative enzymes at high levels, are able to sporulate in the presence of glucose, have severely reduced transformation efficiencies, and are nonmotile. We isolated and sequenced the sacU gene region of Bacillus subtilis. Two open reading frames were found in the sacU region, and sacU(Hy) mutations were localized to both of these open reading frames. The two open reading frames have similarities to two widespread families of proteins that mediate responses to environmental stimuli. PMID:3141378

Henner, D J; Yang, M; Ferrari, E

1988-01-01

208

Endocrine Tumor  

MedlinePLUS

... are here Home > Types of Cancer > Endocrine Tumor Endocrine Tumor This is Cancer.Net’s Guide to Endocrine Tumor. Use the menu below to choose the ... social workers, and patient advocates. Cancer.Net Guide Endocrine Tumor Overview Statistics Risk Factors Symptoms and Signs ...

209

Adenocarcinoma Arising from Sacrococcygeal Mature Teratoma in an Adult Female: Report of a Case  

PubMed Central

We report a case of adenocarcinoma arising from a sacrococcygeal mature teratoma in an adult female. A 62-year-old female was diagnosed with a presacral tumor 10?years ago. Pelvic computed tomography (CT) demonstrated a presacral heterogeneous tumor, containing multiloculated cystic area and enhanced solid component with calcification. Percutaneous needle biopsy for the solid component of the tumor identified an adenocarcinoma and the patient was diagnosed as having a sacrococcygeal teratoma with malignant transformation. Abdomino-sacral rectal resection with sacral amputation at the upper edge of the S5 was performed. The pathological diagnosis was adenocarcinoma derived from a mature teratoma. The tumor cells had infiltrated the rectal wall. After 7?months, a follow-up CT demonstrated swelling of the right inguinal lymph nodes and a right inguinal lymphadenectomy was performed. Pathological examination showed metastatic lymph nodes. The patient is doing well 21?months after the second surgery, with no signs of recurrence. PMID:24904830

Matsumoto, Naoki; Uehara, Keisuke; Ando, Masataka; Arimoto, Junki; Kato, Takehiro; Nakamura, Hayato; Ebata, Tomoki; Yokoyama, Yukihiro; Nagino, Masato

2014-01-01

210

Endobronchial glomus tumor.  

PubMed

We report a case of a 52-year-old patient who had undergone a bladder resection and an ileal conduit for a transitional cell carcinoma. He then presented with a short history of hemoptysis 3 months later. Rigid bronchoscopy was performed revealing an endobronchial lesion, which was removed via laser and debulking method without complications. Histopathologic examination confirmed it to be a benign endobronchial glomus tumor. On the basis of our literature search, this is the 34th reported case of glomus tumor arising from the respiratory tract, seventh reported case of an endobronchial glomus tumor treated bronchoscopically, and the first possibly coincidental finding in relation to a patient with primary transitional bladder cell carcinoma. PMID:25590487

Rashid Ali, Muhammad R S; Kannan, Kunji K S

2015-01-01

211

Boundary estimation problems arising in thermal tomography  

NASA Technical Reports Server (NTRS)

Problems on the identification of two-dimensional spatial domains arising in the detection and characterization of structural flaws in materials are considered. For a thermal diffusion system with external boundary input, observations of the temperature on the surface are used in a output least squares approach. Parameter estimation techniques based on the method of mappings are discussed and approximation schemes are developed based on a finite element Galerkin approach. Theoretical convergence results for computational techniques are given and the results are applied to experimental data for the identification of flaws in the thermal testing of materials.

Banks, H. T.; Kojima, Fumio; Winfree, W. P.

1989-01-01

212

Torsion of the hernia sac within a hydrocele of the scrotum in a child.  

PubMed

Torsion of the hernia sac is a rare disease that presents as acute scrotum in children. Including the present case, only six cases have been reported in the English literature. We report a 10-year-old boy who presented with pain and swelling of his right scrotum. Ultrasonography revealed a hypoechoic region adjacent to the normal right testis. The inflammatory changes of the right scrotum deteriorated. The patient underwent surgery and a necrotic cyst was recognized within a hydrocele of the scrotum. The cyst was not connected with the testis or epididymis and was twisted at an angle of 270 degrees. The cause of the necrotic cyst observed was anatomical and pathological torsion of the hernia sac. PMID:15379947

Matsumoto, Akihiko; Nagatomi, Yutaka; Sakai, Masato; Oshi, Masaya

2004-09-01

213

Lacrimal sac compression by an anterior ethmoidal mucocele presenting as a late complication of dacryocystorhinostomy  

PubMed Central

This was an unusual case of lacrimal sac compression by an anterior ethmoidal mucocele presenting as a late complication of a dacryocystorhinostomy (DCR) that was jointly managed by ophthalmic and ENT surgeons via an endoscopic approach. A 22-year-old lady presented with a 12-month history of a painless lump in her left medial canthus area and a 6-month history of left intermittent epiphora. She had a DCR when she was 15 years old with initial symptom control until recent recurrence. There were no nasal or other eye symptoms. The rest of the eye and nasendoscopic examinations were unremarkable. An MRI scan suggested a dacryocystocele; however, a further CT scan revealed a 1.6 cm cystic lesion consistent with an anterior ethmoidal mucocele compressing the lacrimal sac. An endoscopic left anterior ethmoidectomy with marsupialisation of the mucocele was performed in combination with an endoscopic DCR. She made good post-operative recovery. PMID:24964413

Olaleye, Oladejo; Salleh, Shizalia; David, Don; Bickerton, Richard

2013-01-01

214

Primary intraosseous squamous cell carcinoma of the maxilla possibly arising from an infected residual cyst: A case report  

PubMed Central

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare type of odontogenic carcinoma arising from the jawbone. Odontogenic cysts are true cysts that arise from the dental epithelium, which is associated with tooth formation. The epithelial lining of odontogenic cysts has the potential to transform into various types of odontogenic tumor; however, this transformation from an odontogenic cyst to a malignant tumor is rare. The definitive diagnosis for PIOSCC generally requires the observation of either features of squamous cell carcinoma (SCC) within the jawbone that are distinct from direct invasion from the surface oral epithelium, or evidence of SCC arising from odontogenic epithelium and from tumors that have metastasized to the jawbone from distant sites. In the present study, a case of PIOSCC of the maxilla is presented, which, based on the results of computed tomography and the clinical course, was hypothesized to have originated from an infected residual cyst. PMID:25435946

SUKEGAWA, SHINTARO; MATSUZAKI, HIDENOBU; KATASE, NAOKI; KANNO, TAKAHIRO; MANDAI, TOSHIKO; TAKAHASHI, YUKA; ASAUMI, JUN-ICHI; FURUKI, YOSHIHIKO

2015-01-01

215

AUTORADIOGRAPHIC STUDY OF SUGAR AND AMINO ACID ABSORPTION BY EVERTED SACS OF HAMSTER INTESTINE  

Microsoft Academic Search

Autoradiographs were prepared from frozen sections of evcrted sacs of hamster jejunum which had been incubated in vitro with C 14- or H~-labcled sugars and amino acids. When such tissue was incubated in 1 mM solutions of L-valine or L-methionine, columnar absorp- tivc cells at tips of villi accumulated these amino acids to conccntrations ranging from 5 to 50 millimoles

WILLIAM B. KINTER; T. HASTINGS WILSON

1965-01-01

216

The internal vertebral venous plexus prevents compression of the dural sac during atlanto-axial rotation  

Microsoft Academic Search

Deformation of the extradural space and the possibility of impression upon the dural sac during atlanto-axial rotation are\\u000a investigated. Atlanto-axial rotation leads to a reduction in the cross-sectional area of the bony spinal canal of approximately\\u000a 40 %. Atlanto-axial rotation was recorded by endocanalar views from a video camera fixed inside the skull of six unembalmed\\u000a cadavers. Axial thin-section T1-weighted

E. M. Reesink; J. T. Wilmink; H. Kingma; L. M. A. Lataster; H. van Mameren

2001-01-01

217

Isolated fluid in the cul-de-sac: How well does it predict ectopic pregnancy?  

Microsoft Academic Search

We examined the risk of ectopic pregnancy among patients with isolated abnormal cul-de-sac fluid at transvaginal ultrasound. We conducted a retrospective cohort study of all ED patients presenting January 1995 to August 1999 with abdominal pain or vaginal bleeding and a positive [beta ]-hCG test. The risk of ectopic pregnancy in patients with a moderate volume of anechoic fluid was

Robert Dart; Samuel A. McLean; Linda Dart

2002-01-01

218

Volatile constituents of dog ( Canis familiaris ) and coyote ( Canis latrans ) anal sacs  

Microsoft Academic Search

The volatile organic compounds from the anal sac secretions of male and female dogs and coyotes were examined using gas chromatography and gas chromatography-mass spectrometry. Short chain (C2–C6) acids and trimethylamine were major constituents. Changes in the type and abundance of the volatiles were examined across state of estrus, species, and gender. No consistent difference in the pattern of volatiles

George Preti; Earl L. Muetterties; Joseph M. Furman; James J. Kennelly; Bradford E. Johns

1976-01-01

219

Molecular markers of yolk sac fry development in nine families of lake trout.  

PubMed

Salmonids in certain areas of North America and northern Europe suffer from reproductive disturbances manifested through the death of yolk sac fry. These disturbances are referred to as early mortality syndrome (EMS) in the Great Lakes region and M74 in the Baltic Sea. Both of these syndromes have been associated with reduced concentrations of thiamine in affected females and their eggs. However, large variations in signs and mortality, both within and between the individual syndromes, have been reported. Yolk sac fry mortality (M74) in Atlantic salmon Salmo salar has been shown to be associated with reduced DNA binding of the hypoxia-inducible transcription factor 1 (HIF-1), reduced production of vascular endothelial growth factor (VEGF) protein, decreased capillary density, and down-regulation of adult-type globin gene transcription (which is responsible for the protein part of adult hemoglobin). One of the main effects of all of these changes is reduced oxygen transport to the tissues of affected fry. In this study, the developmental patterns of HIF-1 DNA binding, VEGF protein expression, and adult-type globin gene transcription were analyzed in nine family groups of Lake Michigan lake trout Salvelinus namaycush. The results indicate that HIF-1 DNA binding and globin gene transcription increase from hatch to the end of yolk sac stage. Interindividual and between-family biological variations were detected, especially in VEGF protein expression and globin gene transcription. Our results demonstrate the possibility of using these molecular markers in investigating the etiology of EMS and making comparisons between the mechanisms of different salmonid yolk sac fry mortalities. PMID:20218502

Vuori, Kristiina A; Paavilainen, Tiia; Nikinmaa, Mikko; Czesny, Sergiusz; Rinchard, Jacques

2009-12-01

220

La tumeur testiculaire du sac vitellin: une entité rare chez l'adulte  

PubMed Central

La tumeur testiculaire du sac vitellin pure est rare chez l'adulte. Son diagnostic est histologique, elle reproduit une structure extra-embryonnaire (le tissue du sinus endodermique). Son traitement est codifié. Le pronostic est moins bon chez l'adulte. Nous en rapportons un cas et nous discutons l'histogénèse, les attitudes thérapeutiques, le suivi et le pronostic chez l'adulte. PMID:25400847

Alami, Mohammed; Janane, Abdellatif; Abbar, Mohamed; Ameur, Ahmed; Ghadouane, Mohamed

2014-01-01

221

Figure 3: Stress vs. Strain curve for Bulk SAC305 0 0.2 0.4 0.6  

E-print Network

SAC 305 solders (Canfield Technologies) were machined into dog bone shaped samples according to ASTM-E: Sn-Ag-Cu system phase diagram focused on Sn dominated portion SEM Analysis: 50 MPa Fatigue 70 MPa

Bernstein, Joseph B.

222

Characterization of calcium carbonate crystals in pigeon yolk sacs with different incubation times.  

PubMed

Calcium carbonate crystals are known to form in the yolk sacs of fertile pigeon eggs at late stages of incubation. The composition and structure of these crystals were investigated, the crystallization environment was inspected, and the physical chemistry constants of the yolk fluid were determined through the incubation period. Polarized light microscopy was used to observe the generation and distribution of calcium carbonate crystals in the yolk sac. In addition, X-ray diffraction was employed to analyze the composition and crystal phase of the yolk sac. A decalcification and deproteination method was established to analyze the ultrastructure and composition of the crystals, as well as the internal relationship between inorganic and organic phases of the crystals. Additionally, scanning electron microscopy, transmission electron microscopy, X-ray energy dispersive spectroscopy, and Fourier transform infrared spectroscopy were used to evaluate the characteristics of the crystals. Our results demonstrated that the calcium carbonate crystals were mainly composed of vaterite and calcite, with vaterite being the major component. Vaterite, a type of biomaterial generated by an organic template control, presented as a concentric hierarchical spherical structure. The organic nature of the biomaterial prevented vaterite from transforming into calcite, which is more thermodynamically stable than vaterite. Additionally, the configuration, size, and aggregation of vaterite were also mediated by the organic template. This bio-vaterite was found during the incubation period and is valuable in calcium transport during embryonic development. PMID:24602270

Song, Juan; Cheng, Haixia; Shen, Xinyu; Hu, Jingxiao; Tong, Hua

2014-05-01

223

Evaluation of Refractivity Profiles from CHAMP and SAC-C GPS Radio Occultation  

NASA Technical Reports Server (NTRS)

The GeoForschungsZentrum's Challenging Minisatellite Payload for Geophysical Research and Application (CHAMP, Germany-US) and the Comision Nacional de Actividades Especiales' Satelite de Aplicaciones Cientificas-C (SAC-C, Argentina-US) missions are the first missions to carry a second-generation Blackjack Global Positioning System (GPS) receiver. One of the new features of this receiver is its ability to sense the lower troposphere closer to the surface than the proof-of-concept GPS Meteorology experiment (GPS/MET). Since their launch, CHAMP and SAC-C have collected thousands of GPS radio occultations, representing a wealth of measurements available for data assimilation and Numerical Weather Prediction (NWP). In order to evaluate the refractivity data derived by the Jet Propulsion Laboratory (JPL) from raw radio occultation measurements, we use Data Assimilation Office (DAO) 6-hour forecasts as an independent state of the atmosphere. We compare CHAMP and SAC-C refractivity (processed by JPL) with refractivity calculated from the DAO global fields of temperature, water vapor content and humidity. We show statistics of the differences as well as histograms of the differences.

Poli, Paul; Ao, Chi On; Joiner, Joanna; delaTorreJuarez, Manuel; Hoff, Raymond

2002-01-01

224

Pathological, immunohistochemical and microbiologicalal analysis of lacrimal sac biopsies in patients with chronic dacrocystitis  

PubMed Central

AIM To analyze cases of obstruction of the nasolacrimal duct which creates a fertile environment for secondary bacterial infection and can result in dacryocystitis, which is a constant threat to cornea and orbital soft tissue and a potential source of endophthalmitis following intraocular surgery. The majority of obstructions of the lacrimal excretory outflow system are acquired ones occurring in adulthood and involving the distal parts of the system. Acquired obstruction may be primary/idiopathic or secondary to a wide variety of infectious, inflammatory, traumatic, mechanical, toxic or neoplastic causes mimicking idiopathic inflammation. These cases are treated by dacryocystorhinostomy (DCR). METHODS The present study was conducted to determine the histopathologic, immunohistochemical and current microbiologic characteristics of lacrimal sac specimens in patients undergoing external dacryocystorhinostomy. RESULTS Non-specific lacrimal sac pathology was present in all 33 cases and 81.8% of the cases showed moderate chronic inflammation with a chronic inflammatory score (CIS) ranging between 4 and 6, whereas 12.12% showed severe inflammatory changes with a CIS of 7. Mild degree of inflammation was seen in 6.06% with a CIS of 3. The total prevalence of gram-positive, gram-negative, and culture-negative samples were 59.4%, 37.5%, and 3% respectively. CONCLUSION Non-specific chronic inflammation with fibrosis is indeed the most commonly reported histopathological finding in lacrimal sac wall biopsy specimens. PMID:24392331

Amin, Rowayda Mahmoud; Hussein, Faten Aly; Idriss, Hisham Farouk; Hanafy, Nesrine Fathy; Abdallah, Dina Mohamed

2013-01-01

225

Wilms Tumor and the WT1 Gene  

Microsoft Academic Search

Wilms tumor or nephroblastoma is a pediatric kidney cancer arising from pluripotent embryonic renal precursors. Multiple genetic loci have been linked to Wilms tumorigenesis; positional cloning strategies have led to the identification of the WT1 tumor suppressor gene at chromosome 11p13. WT1 encodes a zinc finger transcription factor that is inactivated in the germline of children with genetic predisposition to

Sean Bong Lee; Daniel A Haber

2001-01-01

226

Extraosseous Ewing's tumor of lateral abdominal wall  

PubMed Central

Extraosseous Ewings tumor (EES) is a rare entity. Few cases have been reported in literature. There are no specific guidelines for management of this disease. We are reporting a case of EES arising from left lateral abdominal wall. We did wide excision of tumor followed by chemoradiation. Patient is asymptomatic after 8 months of follow up. PMID:24765376

Gupta, Nikhil; Chand, Tirlok; Yadav, Nidhi; Kumar, Rajeev; Chauhan, Devender S.; Chaudhary, Poras; Arora, Mohinder P.

2011-01-01

227

Glypican 3 expression in pediatric malignant solid tumors.  

PubMed

Purpose?Glypican 3 (GPC3) is one of the cell surface heparan sulfate proteoglycans that binds to the cell membrane, and it is known as an oncofetal protein in adult malignant tumors. Clinical trials using a GPC3 peptide vaccine have already been started in Japan as a new immunotherapy for hepatocellular carcinoma in adult patients. To investigate the possibility of GPC3 immunotherapy for pediatric malignant tumors, we assessed the expression of GPC3 in pediatric malignant tumors. Methods?Immunohistochemically, the GPC3 expression was examined in 159 pediatric solid tumors, including 35 cases of neuroblastoma, 30 cases of Wilms tumor, 10 cases of hepatoblastoma, 25 cases of germ cell tumors, 56 cases of rhabdomyosarcoma, and 3 cases of other tumors. In addition, to clarify the physiological expression during the fetal to neoinfantile period, autopsy specimens of subjects without any neoplastic diseases were assessed in 9 fetal cases and 21 neoinfantile cases. The serum levels of GPC3 were also analyzed using specimens obtained from 53 subjects by the sandwich enzyme-linked immunosorbent assay method. Results?Histologically, a high rate of GPC3 expression was noted in 10 (90.9%) of the 11 subjects with yolk sac tumors and 6 (60.0%) of the 10 subjects with hepatoblastoma. In addition, 9 (30.0%) of the 30 subjects with Wilms tumors and 14 (25.0%) of the 56 subjects with rhabdomyosarcoma were positive for the expression of GPC3. Concerning autopsy specimens, most of the 23 subjects younger than 7 months showed positive findings in the liver (94.7%) and kidney (81.8%). Two subjects (100%) with yolk sac tumors and six (75.0%) of the eight subjects with hepatoblastoma serologically demonstrated a high rate of positive expression. Concerning the distribution of the serum GPC3 level according to age, 8 (80.0%) of the 10 subjects younger than 1?year showed a positive finding, while only 16 (37.3%) of the 43 subjects older than 1?year showed a positive finding. Conclusion?Most cases of hepatoblastoma and yolk sac tumor, and some cases of other tumors were found to express GPC3 either histologically or serologically. On the other hand, GPC3 was physiologically expressed during the fetal and neoinfantile period under 1?year of age. Although, more preliminary data and experience are required, patients older than 1?year that show a positive finding for GPC3 are considered to be appropriate candidates to receive the new immunotherapy using GPC3 peptide vaccination. PMID:25344940

Kinoshita, Yoshiaki; Tanaka, Sakura; Souzaki, Ryota; Miyoshi, Kina; Kohashi, Kenichi; Oda, Yoshinao; Nakatsura, Tetsuya; Taguchi, Tomoaki

2015-02-01

228

Sites of positive and negative regulation in the Bacillus subtilis antiterminators LicT and SacY.  

PubMed

The Bacillus subtilis homologous transcriptional antiterminators LicT and SacY control the inducible expression of genes involved in aryl beta-glucoside and sucrose utilization respectively. Their RNA-binding activity is carried by the N-terminal domain (CAT), and is regulated by two similar C-terminal domains (PRD1 and PRD2), which are the targets of phosphorylation reactions catalysed by the phosphoenolpyruvate: sugar phosphotransferase system (PTS). In the absence of the corresponding inducer, LicT is inactivated by BglP, the PTS permease (EII) specific for aryl beta-glucosides, and SacY by SacX, a negative regulator homologous to the EII specific for sucrose. LicT, but not SacY, is also subject to a positive control by the general PTS components EI and HPr, which are thought to phosphorylate LicT in the absence of carbon catabolite repression. Construction of SacY/LicT hybrids and mutational analysis enabled the location of the sites of this positive regulation at the two phosphorylatable His207 and His269 within LicT-PRD2, and suggested that the presence of negative charges at these sites is sufficient for LicT activation in vivo. The BglP-mediated inhibition process was found to essentially involve His100 of LicT-PRD1, with His159 of the same domain playing a minor role in this regulation. In vitro experiments indicated that His100 could be phosphorylated directly by the general PTS proteins, this phosphorylation being stimulated by phosphorylated BglP. We confirmed that, similarly, the corresponding conserved His99 residue in SacY is the major site of the negative control exerted by SacX on SacY activity. Thus, for both antiterminators, the EII-mediated inhibition process seems to rely primarily on the presence of a negative charge at the first conserved histidine of the PRD1. PMID:11580842

Tortosa, P; Declerck, N; Dutartre, H; Lindner, C; Deutscher, J; Le Coq, D

2001-09-01

229

Activity of digestive enzymes in yolk-sac larvae of Atlantic halibut ( Hippoglossus hippoglossus): indication of readiness for first feeding  

Microsoft Academic Search

The problem of determining when larvae should be offered food is particularly difficult in a species such as Atlantic halibut that has a long yolk-sac period (280–320 degree days, dd). In order to help determine at what age Atlantic halibut larvae are able to digest food, we compared the activities of key digestive enzymes in four yolk-sac stages at an

Anna Gawlicka; Brigitte Parent; Michael H Horn; Neil Ross; Ingegjerd Opstad; Ole J Torrissen

2000-01-01

230

Influencing Factors for Abdominal Aortic Aneurysm Sac Shrinkage and Enlargement after EVAR: Clinical Reviews before Introduction of Preoperative Coil Embolization  

PubMed Central

Background: We previously reported effectiveness of coil embolization (CE) to aortic branched vessels before endovascular aortic repair (EVAR) for abdominal aortic aneurysm (AAA) because of significant shrinkage of aneurysmal sac. In this study, we investigated EVAR cases to clarify influential factors of aneurysmal shrinkage and enlargement. Methods: 148 consecutive cases before the introduction of CE were retrospectively reviewed based on the presence of PT2EL (persistent type 2 endoleak) and change in sac diameter after EVAR by multivariate analysis. Results: (A) PT2EL risk factors were patent inferior mesenteric artery (IMA) and thinner mural thrombus inside aneurysmal sac. (B) Sac enlargement risk factors were antiplatelet intake, PT2EL, and female gender. (C) Sac shrinkage predictive factors were the absences of thoracic aortic aneurysm, antiplatelet intake, PT2EL, and coronary artery disease. Conclusion: CE to IMA was considered to be effective because patent IMA and antiplatelet intake were significant risk factors for sac enlargement. So, more meticulous therapeutic strategy, including treatment priority (AAA first or CAD first) and choice of treatment (EVAR vs. AAA) based on anatomical features of AAA was required to improve late outcomes. PMID:25298830

Hiraoka, Arudo; Totsugawa, Toshinori; Tamura, Kentaro; Ishida, Atsuhisa; Sakaguchi, Taichi; Yoshitaka, Hidenori

2014-01-01

231

Castor sacs and anal glands of the north american beaver (Castor canadensis): their histology, development, and relationship to scent communication.  

PubMed

Both sexes of beavers possess a pair of castor sacs and a pair of anal glands located in paired subcutaneous cavities between the pelvis and the base of the tail. The castor sacs are not glandular in the histological sense, hence references to these structures as preputial glands or castor glands are misnomers. The wall of the castor sacs is plicate and comprised of three distinct zones: an outer layer of vascular connective tissue, a two-to five-cell-thick layer of mitotic epithelial cells, and several densely packed layers of cornified epithelium which grade into more widely separated sheets toward the lumen. Monocultures of a gram-positive facultatively anaerobic bacterium were present in the lumen of all castor sac preparations. Differences in the frequency of castoreum deposition were not attributable to differences in the structure of the castor sacs. The anal glands of beavers are holocrine sebaceous glands. These glands develop more rapidly than the castor sacs. Anal gland tissue from embryos exhibited cellular characteristics associated with the production of sebum. Secretory activity was evident in all preparations. The relationship of castoreum and anal gland secretion to scent communication among beavers is discussed. PMID:24415179

Walro, J M; Svendsen, G E

1982-05-01

232

Ultrastructure of the endolymphatic sac in the larva of the japanese red-bellied newt Cynops pyrrhogaster  

NASA Technical Reports Server (NTRS)

The ultrastructure of the endolymphatic sac (ES) of the late stage larva of the Japanese red-bellied newt, Cynops pyrrhogaster (stage 57), was examined by light and transmission electron microscopy. The two endolymphatic sacs are located at the dorsal-medial side of the otic vesicle on the dorsal-lateral side of the midbrain in the cranial cavity. The wall of the sac is composed of a layer of cubical epithelial cells with loose, interposed intercellular spaces. The sac contains a large luminal cavity, in which endolymph and numerous otoconia are present. The epithelial cells of different portions of the sac have a similar structure. These cells contain an abundance of cytoplasmic organelles, including ribosomes, Golgi complexes, and numerous vesicles. Two types of vesicles are found in the epithelial cells: the "floccular" vesicle and the "granular" vesicle. The floccular vesicles are located in the supra- and lateral-nuclear cytoplasm and contain floccular material. The granular vesicles have a fine granular substance and are usually situated apposed to the apical cell membrane. The granular vesicles are suggested to be secreted into the lumen, while the floccular vesicles are thought to be absorbed from the lumen and conveyed to the intercellular spaces by the epithelial cells. The apical surfaces of the epithelial cells bear numerous microvilli. Apparently floating cells, which bear long microvilli on the free surfaces, are observed in the lumen of the ES. Based on the fine structure, the function of the endolymphatic sac of the newt Cynops pyrrhogaster is discussed.

Gao, W.; Wiederhold, M.; Hejl, R.

1998-01-01

233

Liposarcoma: a soft tissue tumor with many presentations.  

PubMed

Liposarcoma is an uncommon connective tissue tumor arising from lipoblast cells. The lesion is located in body soft parts and rarely arises from the bones. The tumors are variable in presentation ranging from benign well-differentiated tumors to myxoid and round cell-dedifferentiated and pleomorphic forms which can present with metastases. The lesions are most often treated by surgical resection. Chemotherapy and radiation may be added to the treatment of the more malignant variants with some success. PMID:25047632

Mankin, H J; Mankin, K P; Harmon, D C

2014-12-01

234

[Granulosa cell tumors of the ovary].  

PubMed

Ovarian granulosa cell tumors (TGO) are rare neoplasms. They arise from sex cord stromal cells of the ovaries. They are characterized by their slow natural history, and their tendency to relapse long time after the initial diagnosis. Complete staging surgery of the disease is the cornerstone of treatment. Chemotherapy is indicated for localized tumors with a high risk of recurrence, and for recurrent or advanced tumors. Prolonged follow-up is recommended. PMID:24445864

Sekkate, Sakina; Kairouani, Mouna; Serji, Badr; M'Rabti, Hind; El Ghissassi, Ibrahim; Errihani, Hassan

2014-01-01

235

A Case of Large Mucinous Adenocarcinoma Arising in a Long-Standing Fistula-in-Ano  

Microsoft Academic Search

Background: Chronic anal fistulas are not rare conditions, however, the development of a carcinoma in a long-standing fistula-in-ano is rare. Methods: The case of a 77-year-old male with a large perianal mucinous adenocarcinoma arising in a long-standing fistula-in-ano is presented. Results: Perianal biopsy revealed mucinous adenocarcinoma. Abdominal CT, double contrast barium examination and flexible sigmoidoscopy revealed no other tumoral lesion

Yamac Erhan; Aslan Sakarya; Hasan Aydede; Akif Demir; Ahmet Seyhan; Emre Atici

2003-01-01

236

Papillary tumor of the pineal region  

PubMed Central

Presented is a patient with papillary tumor of the pineal region (PTPR), an uncommon and recently recognized neoplasm. As its name implies, PTPR does not arise from the pineal gland itself. The cell of origin is thought to be the specialized ependymocytes of the subcommissural organ. Primary tumors of the pineal region include pineal parenchymal neoplasms, germ cell neoplasms, and tumors arising from adjacent structures, including meningiomas, astrocytomas, and ependymomas. Like other masses in this location, PTPR often leads to obstructive hydrocephalus. Due to the relative paucity of reported cases of PTPR, its natural history is unknown. PMID:22275792

Opatowsky, Michael; O'Rourke, Brian; Layton, Kennith

2012-01-01

237

Papillary tumor of the pineal region.  

PubMed

Presented is a patient with papillary tumor of the pineal region (PTPR), an uncommon and recently recognized neoplasm. As its name implies, PTPR does not arise from the pineal gland itself. The cell of origin is thought to be the specialized ependymocytes of the subcommissural organ. Primary tumors of the pineal region include pineal parenchymal neoplasms, germ cell neoplasms, and tumors arising from adjacent structures, including meningiomas, astrocytomas, and ependymomas. Like other masses in this location, PTPR often leads to obstructive hydrocephalus. Due to the relative paucity of reported cases of PTPR, its natural history is unknown. PMID:22275792

Vandergriff, Clayton; Opatowsky, Michael; O'Rourke, Brian; Layton, Kennith

2012-01-01

238

Wilms' Tumor  

MedlinePLUS

Wilms' tumor is a rare type of kidney cancer. It causes a tumor on one or both kidneys. It usually affects children, but can happen in adults. Having certain genetic conditions or birth defects can increase ...

239

Urogenital tumors  

SciTech Connect

An overview is provided for veterinary care of urogenital tumors in companion animals, especially the dog. Neoplasms discussed include tumors of the kidney, urinary bladder, prostate, testis, ovary, vagina, vulva and the canine transmissible venereal tumor. Topics addressed include description, diagnosis and treatment.

Weller, R.E.

1994-03-01

240

Merkel cell carcinoma arising in the ear canal.  

PubMed

A case of rare tumor, Merkel cell carcinoma, located in the ear canal of a 25-year-old woman is presented. A polypoid tumor mass was extirpated, and tympanoplasty was done at the first operation, whereas at the second operation, all the bones of the ear canal were removed. Epitympanum and cavum were filled with tumor, and the tumor mass was removed in toto. The histopathology and immunohistochemical staining characteristics of tumor confirmed the presence of Merkel cell tumor. Postoperatively, radiation therapy to the tumor bed was completed. There was no clinical or radiographic evidence of recurrence or metastasis of Merkel cell tumor for 3 years. PMID:18387993

Petkovi?, Marija; Krstulja, Mira; Radic, Jelena; Zamolo, Gordana; Muhvi?, Damir; Lovasic, Ingrid; Kujundzic, Milodar; Franko, Artur

2008-07-01

241

Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs)  

SciTech Connect

Highlights: {yields} Endothelin-1 expression by adult rat astrocytes correlates with cell proliferation. {yields} Stretch-induced ET-1 is inhibited by GsMtx-4, a specific inhibitor of Ca{sup 2+} permeant SACs. {yields} The less specific SAC inhibitor streptomycin also inhibits ET-1 secretion. {yields} Stretch-induced ET-1 production depends on a calcium influx. {yields} SAC pharmacology may provide a new class of therapeutic agents for CNS pathology. -- Abstract: The expression of endothelins (ETs) and ET-receptors is often upregulated in brain pathology. ET-1, a potent vasoconstrictor, also inhibits the expression of astrocyte glutamate transporters and is mitogenic for astrocytes, glioma cells, neurons, and brain capillary endothelia. We have previously shown that mechanical stress stimulates ET-1 production by adult rat astrocytes. We now show in adult astrocytes that ET-1 production is driven by calcium influx through stretch-activated ion channels (SACs) and the ET-1 production correlates with cell proliferation. Mechanical stimulation using biaxial stretch (<20%) of a rubber substrate increased ET-1 secretion, and 4 {mu}M GsMTx-4 (a specific inhibitor of SACs) inhibited secretion by 30%. GsMTx-4 did not alter basal ET-1 levels in the absence of stretch. Decreasing the calcium influx by lowering extracellular calcium also inhibited stretch-induced ET-1 secretion without effecting ET-1 secretion in unstretched controls. Furthermore, inhibiting SACs with the less specific inhibitor streptomycin also inhibited stretch-induced ET-1 secretion. The data can be explained with a simple model in which ET-1 secretion depends on an internal Ca{sup 2+} threshold. This coupling of mechanical stress to the astrocyte endothelin system through SACs has treatment implications, since all pathology deforms the surrounding parenchyma.

Ostrow, Lyle W., E-mail: lostrow1@jhmi.edu [Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205 (United States); Suchyna, Thomas M.; Sachs, Frederick [Department of Physiology and Biophysical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States)] [Department of Physiology and Biophysical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States)

2011-06-24

242

Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development.  

PubMed

In mice, the yolk sac appears to play a crucial role in nourishing the developing embryo, especially during embryonic days (E) 7;-10. Lipoprotein synthesis and secretion may be essential for this function: embryos lacking apolipoprotein (apo) B or microsomal triglyceride transfer protein (MTP), both of which participate in the assembly of triglyceride-rich lipoproteins, are apparently defective in their ability to export lipoproteins from yolk sac endoderm cells and die during mid-gestation. We therefore analyzed the embryonic expression of apoB, MTP, and alpha-tocopherol transfer protein (alpha-TTP), which have been associated with the assembly and secretion of apoB-containing lipoproteins in the adult liver, at different developmental time points. MTP expression or activity was found in the yolk sac and fetal liver, and low levels of activity were detected in E18.5 placentas. alpha-TTP mRNA and protein were detectable in the fetal liver, but not in the yolk sac or placenta. Ultrastructural analysis of yolk sac visceral endoderm cells demonstrated nascent VLDL within the luminal spaces of the rough endoplasmic reticulum and Golgi apparatus at E7.5 and E8.5. The particles were reduced in diameter at E13.5 and reduced in number at E18.5;-19. The data support the hypothesis that the yolk sac plays a vital role in providing lipids and lipid-soluble nutrients to embryos during the early phases (E7;-10) of mouse development. secretion in mouse yolk sac during embryonic development. PMID:10553000

Terasawa, Y; Cases, S J; Wong, J S; Jamil, H; Jothi, S; Traber, M G; Packer, L; Gordon, D A; Hamilton, R L; Farese, R V

1999-11-01

243

How does LCDFT compare to SAC-CI for the treatment of valence and Rydberg excited states of organic compounds?  

PubMed

The computation of excitation energies for electronically excited states poses a challenge in quantum chemistry. In the present work, the performance of two related methodologies in this context, symmetry-adapted cluster-configuration interaction (SAC-CI) and time-dependent long-range corrected density functional theory (TDLCDFT), is compared in detail for the calculation of valence and Rydberg excitation energies against an experimental benchmark set comprising some organic compounds from different categories. Practically, the single- and double-linked excitation operators are considered in the SAC-CI wave functions. The considered LC density functionals include the combination forms of exchange and correlation functionals (BLYP, PBE, TPSS), pure functionals (tHCTH and B97-D), exchange-only functionals (HFS, HFB, and XAlpha), hybrid functionals (CAM-B3LYP, LC-?PBE, ?B97, ?B97X), and dispersion-corrected hybrid functional ?B97X-D. Our results reveal that the SAC-CI gives the best performance for Rydberg excited states. However, the values of mean absolute deviation show that the applicability of some LC functionals is comparable to SAC-CI. For valence excited states, the functionals ?B97X-D, ?B97X, and LC-?PBE outperform the other tested methods. Overall, the ?B97X-D functional is found to offer the best performance, and its validity compared with SAC-CI has also been verified by computing low-lying excited states of a few molecules as representative examples. Lastly, it is shown that not only is there a reasonable agreement between TDLCDFT and SAC-CI methods for the calculation of excitation energies but also the LC density functionals have quantitatively better overall performance for some excited states than the SAC-CI approach. PMID:24559047

Alipour, Mojtaba

2014-03-01

244

Anal sac secretion of the red fox, Vulpes vulpes ; volatile fatty acids and diamines: Implications for a fermentation hypothesis of chemical recognition  

Microsoft Academic Search

Putrescine (1,4-diaminobutane) and cadaverine (1,5-di-aminopentane) were identified in the anal sac secretions of the red fox,Vulpes vulpes, and of the lion, Panthera leo. Anal sac secretion samples obtained over a period of 10 weeks by sampling from within each sac of each of 6 captive foxes were analyzed and putrescine, cadaverine, and volatile fatty acid compositions and secretion pH values

E. S. Albone; G. C. Perry

1976-01-01

245

Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.  

PubMed

PiT-1 protein is a transmembrane sodium-dependent phosphate (Pi) transporter. PiT-1 knock out (KO) embryos die from largely unknown causes by embryonic day (E) 12.5. We tested the hypothesis that PiT-1 is required for endocytosis in the embryonic yolk sac (YS) visceral endoderm (VE). Here we present data supporting that PiT-1 KO results in a YS remodeling defect and decreased endocytosis in the YS VE. The remodeling defect is not due to an upstream cardiomyocyte requirement for PiT-1, as SM22?Cre-specific KO of PiT-1 in the developing heart and the YS mesodermal layer (ME) does not recapitulate the PiT-1 global KO phenotype. Furthermore, we find that high levels of PiT-1 protein localize to the YS VE apical membrane. Together these data support that PiT-1 is likely required in YS VE. During normal development maternal immunoglobulin (IgG) is endocytosed into YS VE and accumulates in the apical side of the VE in a specialized lysosome termed the apical vacuole (AV). We have identified a reduction in PiT-1 KO VE cell height and a striking loss of IgG accumulation in the PiT-1 KO VE. The endocytosis genes Tfeb, Lamtor2 and Snx2 are increased at the RNA level. Lysotracker Red staining reveals a loss of distinct AVs, and yolk sacs incubated ex vivo with phRODO Green Dextran for Endocytosis demonstrate a functional loss of endocytosis. As yolk sac endocytosis is controlled in part by microautophagy, but expression of LC3 had not been examined, we investigated LC3 expression during yolk sac development and found stage-specific LC3 RNA expression that is predominantly from the YS VE layer at E9.5. Normalized LC3-II protein levels are decreased in the PiT-1 KO YS, supporting a requirement for PiT-1 in autophagy in the YS. Therefore, we propose the novel idea that PiT-1 is central to the regulation of endocytosis and autophagy in the YS VE. PMID:25138534

Wallingford, Mary C; Giachelli, Cecilia M

2014-08-01

246

Early sac shrinkage predicts a low risk of late complications after endovascular aortic aneurysm repair  

PubMed Central

Background Aneurysm shrinkage has been proposed as a marker of successful endovascular aneurysm repair (EVAR). Patients with early postoperative shrinkage may experience fewer subsequent complications, and consequently require less intensive surveillance. Methods Patients undergoing EVAR from 2000 to 2011 at three vascular centres (in 2 countries), who had two imaging examinations (postoperative and after 6–18 months), were included. Maximum diameter, complications and secondary interventions during follow-up were registered. Patients were categorized according to early sac dynamics. The primary endpoint was freedom from late complications. Secondary endpoints were freedom from secondary intervention, postimplant rupture and direct (type I/III) endoleaks. Results Some 597 EVARs (71·1 per cent of all EVARs) were included. No shrinkage was observed in 284 patients (47·6 per cent), moderate shrinkage (5–9 mm) in 142 (23·8 per cent) and major shrinkage (at least 10 mm) in 171 patients (28·6 per cent). Four years after the index imaging, the rate of freedom from complications was 84·3 (95 per cent confidence interval 78·7 to 89·8), 88·1 (80·6 to 95·5) and 94·4 (90·1 to 98·7) per cent respectively. No shrinkage was an independent risk factor for late complications compared with major shrinkage (hazard ratio (HR) 3·11; P < 0·001). Moderate compared with major shrinkage (HR 2·10; P = 0·022), early postoperative complications (HR 3·34; P < 0·001) and increasing abdominal aortic aneurysm baseline diameter (HR 1·02; P = 0·001) were also risk factors for late complications. Freedom from secondary interventions and direct endoleaks was greater for patients with major sac shrinkage. Conclusion Early change in aneurysm sac diameter is a strong predictor of late complications after EVAR. Patients with major sac shrinkage have a very low risk of complications for up to 5 years. This parameter may be used to tailor postoperative surveillance. PMID:24752772

Bastos Gonçalves, F; Baderkhan, H; Verhagen, H J M; Wanhainen, A; Björck, M; Stolker, R J; Hoeks, S E; Mani, K

2014-01-01

247

Digital PCR technology detects brain-tumor-associated mutation in cerebrospinal fluid  

Cancer.gov

Researchers from the Massachusetts General Hospital (a component of the Dana-Farber Cancer Institute) and their colleagues have used digital versions of a standard molecular biology tool to detect a common tumor-associated mutation in the cerebrospinal fluid (CSF) of patients with brain tumors. In their report being published in the open-access journal Molecular Therapy – Nucleic Acids, the investigators describe using advanced forms of the gene-amplification technology polymerase chain reaction (PCR) to analyze bits of RNA carried in membrane-covered sacs called extracellular vesicles for the presence of a tumor-associated mutation in a gene called IDH1.

248

Tumors of the thymus.  

PubMed

Thymic neoplasms are a common cause of an anterior mediastinal mass and may be benign or malignant. Thymic cysts are congenital or acquired and may be associated with a thymic malignancy. True thymic hyperplasia and thymic lymphoid hyperplasia may enlarge the thymus and simulate a neoplasm. Thymoma and thymic carcinoma are epithelial malignancies with distinct clinicopathologic features. Thymic carcinoid is a rare aggressive neuroendocrine malignancy associated with multiple endocrine neoplasia 1. Thymolipoma is a benign neoplasm. Hodgkin and non-Hodgkin lymphoma may primarily or secondarily involve the thymus. Primary mediastinal germ cell tumors may arise primarily within the thymus and include mature teratoma, seminoma, and non-seminomatous malignant germ cell tumors. PMID:10404501

Strollo, D C; Rosado-de-Christenson, M L

1999-07-01

249

Crystal structure of a new RNA-binding domain from the antiterminator protein SacY of Bacillus subtilis.  

PubMed Central

SacY belongs to a family of, at present, seven bacterial transcriptional antiterminators. The RNA-binding and antitermination capacity of SacY resides in the 55 amino acids at the N-terminal [SacY(1-55)]. The crystal structure at 2 A resolution shows that SacY(1-55) forms a dimer in the crystal, in accordance with the NMR solution structure. The structure of the monomer is a four-stranded beta-sheet with a simple beta1beta2beta3beta4 topology. One side of the sheet is covered by a long surface loop and the other side forms the dimer interface. The dimer is stabilized by the orthogonal stacking of the two beta-sheets. The crystal structure is in excellent agreement with the NMR solution structure (r.m.s. distance for C alpha coordinates is 1.3 A). The structure of SacY(1-55) reveals a new RNA-binding motif. PMID:9305644

van Tilbeurgh, H; Manival, X; Aymerich, S; Lhoste, J M; Dumas, C; Kochoyan, M

1997-01-01

250

Eccrine Hidrocystoma Arising at the Tarsal Plate during Childhood.  

PubMed

A 2-year-old boy with an upper-eyelid tumor in his right eye underwent complete resection. Pathological examination showed that the tumor was composed of a thin wall, lined by a single cuboidal epithelium, and contained a transparent liquid. The epithelium of the tumor wall did not display decapitation and the tumor was diagnosed as eccrine hidrocystoma. After resection, obvious improvement of the tumor-caused blepharoptosis was observed and the visual acuity of the patient recovered. PMID:23904854

Hirata, Akira

2013-05-01

251

Eccrine Hidrocystoma Arising at the Tarsal Plate during Childhood  

PubMed Central

A 2-year-old boy with an upper-eyelid tumor in his right eye underwent complete resection. Pathological examination showed that the tumor was composed of a thin wall, lined by a single cuboidal epithelium, and contained a transparent liquid. The epithelium of the tumor wall did not display decapitation and the tumor was diagnosed as eccrine hidrocystoma. After resection, obvious improvement of the tumor-caused blepharoptosis was observed and the visual acuity of the patient recovered. PMID:23904854

Hirata, Akira

2013-01-01

252

RNA recognition by transcriptional antiterminators of the BglG/SacY family: functional and structural comparison of the CAT domain from SacY and LicT.  

PubMed

Transcriptional antiterminators of the BglG/SacY family are regulatory proteins that mediate the induction of sugar metabolizing operons in Gram-positive and Gram-negative bacteria. Upon activation, these proteins bind to specific targets in nascent mRNAs, thereby preventing abortive dissociation of the RNA polymerase from the DNA template. We have previously characterized the RNA-binding domain of SacY from Bacillus subtilis and determined its three-dimensional structure by both NMR and crystallography. In the present study, we have characterized the paralogous domain from LicT and we present the first structural comparison between two BglG/SacY family members. Similar to SacY, the RNA-binding activity of LicT is contained within the 56 N-terminal amino acid residue fragment corresponding to the so-called co-antiterminator (CAT) domain. Surface plasmon resonance affinity measurements show that, compared to SacY-CAT, LicT-CAT binds more tightly and more specifically to its cognate RNA target, with a KD value of about 10(-8) M. The crystal structure of LicT-CAT has been determined at 1.8 A resolution and compared to that of SacY-CAT. Both molecules fold as symmetrical dimers, each monomer comprising a four-stranded antiparallel beta-sheet that stacks against the beta-sheet of the other monomer in a very conserved manner. Comparison of the proposed RNA-binding surfaces shows that many of the conserved atoms concentrate in a central region across one face of the CAT dimer, whereas variable elements are mostly found at the edges. Interestingly, the electrostatic potential maps calculated for the two molecules are quite different, except for the core of the RNA-binding site, which appears essentially neutral in both structures. PMID:10610766

Declerck, N; Vincent, F; Hoh, F; Aymerich, S; van Tilbeurgh, H

1999-11-26

253

Modeling murine yolk sac hematopoiesis with embryonic stem cell culture systems  

PubMed Central

The onset of hematopoiesis in mammals is defined by generation of primitive erythrocytes and macrophage progenitors in embryonic yolk sac. Laboratories have met the challenge of transient and swiftly changing specification events from ventral mesoderm through multipotent progenitors and maturing lineage-restricted hematopoietic subtypes, by developing powerful in vitro experimental models to interrogate hematopoietic ontogeny. Most importantly, studies of differentiating embryonic stem cell derivatives in embryoid body and stromal coculture systems have identified crucial roles for transcription factor networks (e.g. Gata1, Runx1, Scl) and signaling pathways (e.g. BMP, VEGF, WNT) in controlling stem and progenitor cell output. These and other relevant pathways have pleiotropic biological effects, and are often associated with early embryonic lethality in knockout mice. Further refinement in subsequent studies has allowed conditional expression of key regulatory genes, and isolation of progenitors via cell surface markers (e.g. FLK1) and reporter-tagged constructs, with the purpose of measuring their primitive and definitive hematopoietic potential. These observations continue to inform attempts to direct the differentiation, and augment the expansion, of progenitors in human cell culture systems that may prove useful in cell replacement therapies for hematopoietic deficiencies. The purpose of this review is to survey the extant literature on the use of differentiating murine embryonic stem cells in culture to model the developmental process of yolk sac hematopoiesis.

COOK, Brandoch D.

2014-01-01

254

Giant pandas are not an evolutionary cul-de-sac: evidence from multidisciplinary research.  

PubMed

The giant panda (Ailuropoda melanoleuca) is one of the world's most endangered mammals and remains threatened by environmental and anthropogenic pressure. It is commonly argued that giant pandas are an evolutionary cul-de-sac because of their specialized bamboo diet, phylogenetic changes in body size, small population, low genetic diversity, and low reproductive rate. This notion is incorrect, arose from a poor understanding or appreciation of giant panda biology, and is in need of correction. In this review, we summarize research across morphology, ecology, and genetics to dispel the idea, once and for all, that giant pandas are evolutionary dead-end. The latest and most advanced research shows that giant pandas are successful animals highly adapted to a specialized bamboo diet via morphological, ecological, and genetic adaptations and coadaptation of gut microbiota. We also debunk misconceptions around population size, population growth rate, and genetic variation. During their evolutionary history spanning 8 My, giant pandas have survived diet specialization, massive bamboo flowering and die off, and rapid climate oscillations. Now, they are suffering from enormous human interference. Fortunately, continued conservation effort is greatly reducing impacts from anthropogenic interference and allowing giant panda populations and habitat to recover. Previous ideas of a giant panda evolutionary cul-de-sac resulted from an unsystematic and unsophisticated understanding of their biology and it is time to shed this baggage and focus on the survival and maintenance of this high-profile species. PMID:25274274

Wei, Fuwen; Hu, Yibo; Yan, Li; Nie, Yonggang; Wu, Qi; Zhang, Zejun

2015-01-01

255

Embryo sac formation and early embryo development in Agave tequilana (Asparagaceae).  

PubMed

Agave tequilana is an angiosperm species that belongs to the family Asparagaceae (formerly Agavaceae). Even though there is information regarding to some aspects related to the megagametogenesis of A. tequilana, this is the first report describing the complete process of megasporogenesis, megagametogenesis, the early embryo and endosperm development process in detail. The objective of this work was to study and characterize all the above processes and the distinctive morphological changes of the micropylar and chalazal extremes after fertilization in this species. The agave plant material for the present study was collected from commercial plantations in the state of Jalisco, Mexico. Ovules and immature seeds, previously fixed in FAA and kept in ethanol 70%, were stained based on a tissue clarification technique by using a Mayer's-Hematoxylin solution. The tissue clarification technique was successfully used for the characterization of the megasporogenesis, megagametogenesis, mature embryo sac formation, the early embryo and endosperm development processes by studying intact cells. The embryo sac of A. tequilana was confirmed to be of the monosporic Polygonum-type and an helobial endosperm formation. Also, the time-lapse of the developmental processes studied was recorded. PMID:25332875

González-Gutiérrez, Alejandra G; Gutiérrez-Mora, Antonia; Rodríguez-Garay, Benjamín

2014-01-01

256

Calcitropic gene expression suggests a role for the intraplacental yolk sac in maternal-fetal calcium exchange.  

PubMed

The expression of calcitropic genes and proteins was localized within murine placenta during late gestation (the time frame of active calcium transfer) with an analysis of several gene-deletion mouse models by immunohistochemistry and in situ hybridization. Parathyroid hormone-related protein (PTHrP), the PTH/PTHrP receptor, calcium receptor, calbindin-D(9k), Ca(2+)-ATPase, and vitamin D receptor were all highly expressed in a localized structure of the murine placenta, the intraplacental yolk sac, compared with trophoblasts. In the PTHrP gene-deleted or Pthrp-null placenta in which placental calcium transfer is decreased, calbindin-D(9k) expression was downregulated in the intraplacental yolk sac but not in the trophoblasts. These observations indicated that the intraplacental yolk sac contains calcium transfer and calcium-sensing capability and that it is a probable route of maternal-fetal calcium exchange in the mouse. PMID:11832378

Kovacs, Christopher S; Chafe, Linda L; Woodland, Mandy L; McDonald, Kirsten R; Fudge, Neva J; Wookey, Peter J

2002-03-01

257

Histological Analyses Demonstrate the Temporary Contribution of Yolk Sac, Liver, and Bone Marrow to Hematopoiesis during Chicken Development  

PubMed Central

The use of avian animal models has contributed to the understanding of many aspects of the ontogeny of the hematopoietic system in vertebrates. However, specific events that occur in the model itself are still unclear. There is a lack of consensus, among previous studies, about which is the intermediate site responsible for expansion and differentiation of hematopoietic cells, and the liver's contribution to the development of this system. Here we aimed to evaluate the presence of hematopoiesis in the yolk sac and liver in chickens, from the stages of intra-aortic clusters in the aorta-genital ridges-mesonephros (AGM) region until hatching, and how it relates to the establishment of the bone marrow. Gallus gallus domesticus L. embryos and their respective yolk sacs at embryonic day 3 (E3) and up to E21 were collected and processed according to standard histological techniques for paraffin embedding. The slides were stained with hematoxylin-eosin, Lennert's Giemsa, and Sirius Red at pH 10.2, and investigated by light microscopy. This study demonstrated that the yolk sac was a unique hematopoietic site between E4 and E12. Hematopoiesis occurred in the yolk sac and bone marrow between E13 and E20. The liver showed granulocytic differentiation in the connective tissue of portal spaces at E15 and onwards. The yolk sac showed expansion of erythrocytic and granulocytic lineages from E6 to E19, and E7 to E20, respectively. The results suggest that the yolk sac is the major intermediate erythropoietic and granulopoietic site where expansion and differentiation occur during chicken development. The hepatic hematopoiesis is restricted to the portal spaces and represented by the granulocytic lineage. PMID:24621665

Guedes, Priscila Tavares; de Oliveira, Barbara Cristina Euzébio Pereira Dias; Manso, Pedro Paulo de Abreu; Caputo, Luzia Fátima Gonçalves; Pelajo-Machado, Marcelo

2014-01-01

258

Enlarging cells initiating apomixis in Hieracium praealtum transition to an embryo sac program prior to entering mitosis.  

PubMed

Hieracium praealtum forms seeds asexually by apomixis. During ovule development, sexual reproduction initiates with megaspore mother cell entry into meiosis and formation of a tetrad of haploid megaspores. The sexual pathway ceases when a diploid aposporous initial (AI) cell differentiates, enlarges, and undergoes mitosis, forming an aposporous embryo sac that displaces sexual structures. Embryo and endosperm development in aposporous embryo sacs is fertilization independent. Transcriptional data relating to apomixis initiation in Hieracium spp. ovules is scarce and the functional identity of the AI cell relative to other ovule cell types is unclear. Enlarging AI cells with undivided nuclei, early aposporous embryo sacs containing two to four nuclei, and random groups of sporophytic ovule cells not undergoing these events were collected by laser capture microdissection. Isolated amplified messenger RNA samples were sequenced using the 454 pyrosequencing platform and comparatively analyzed to establish indicative roles of the captured cell types. Transcriptome and protein motif analyses showed that approximately one-half of the assembled contigs identified homologous sequences in Arabidopsis (Arabidopsis thaliana), of which the vast majority were expressed during early Arabidopsis ovule development. The sporophytic ovule cells were enriched in signaling functions. Gene expression indicative of meiosis was notably absent in enlarging AI cells, consistent with subsequent aposporous embryo sac formation without meiosis. The AI cell transcriptome was most similar to the early aposporous embryo sac transcriptome when comparing known functional annotations and both shared expressed genes involved in gametophyte development, suggesting that the enlarging AI cell is already transitioning to an embryo sac program prior to mitotic division. PMID:23864557

Okada, Takashi; Hu, Yingkao; Tucker, Matthew R; Taylor, Jennifer M; Johnson, Susan D; Spriggs, Andrew; Tsuchiya, Tohru; Oelkers, Karsten; Rodrigues, Julio C M; Koltunow, Anna M G

2013-09-01

259

Serous carcinoma arising in endometrial polyps: clinicopathologic study of 4 cases.  

PubMed

Uterine serous carcinoma (USC) is a rare variant of endometrial cancer that is not related to increased estrogen level; rather, it arises in a background of atrophic endometrium. Our aim was to describe clinicopathologic features of 4 cases of USC arising in endometrial polyps (EPs). The mean age of the patients at presentation was 53 years (range, 50-61 years). All patients presented with postmenopausal bleeding. In 3 patients, endometrial curretings were done before surgery, which was reported as EP with superficial foci of USC, EP with few clusters of atypical cells, and high-grade serous carcinoma, respectively. All patients underwent hysterectomy with bilateral salpingo-oophorectomy and omental sampling. The uterine cavity showed an EP in all cases ranging in size from 2 to 3.5 cm (mean, 3 cm). The hysterectomy specimens revealed USC in EP as well as the adjacent endometrium in 3 patients. The nonneoplastic endometrium was atrophic in all cases. Residual tumor was not found in the endometrium in 1 case. Omental metastatic deposits were found in all cases. Tumor deposits were also seen in the serosa of uterus, fallopian tubes, and parametrium in 1 case. Two patients died of disease 2 years after diagnosis. The remaining 2 patients are alive after a follow-up of 3 years, respectively. In conclusion, USC is a rare aggressive tumor, and to establish the diagnosis, it is important to look for the small foci of the tumor in the atrophic endometrium and on the surface of the polyps as these patients are likely to harbor additional disease in the uterus or extrauterine sites. The postmenopausal group is at high risk for developing these tumors; therefore, all the endometrial biopsies/curettings and the EPs in this age group should be thoroughly sampled. PMID:23276456

Idrees, Romana; Din, Nasir Ud; Fatima, Saira; Kayani, Naila

2013-06-01

260

The Role of Elastic and Plastic Anisotropy of Sn in Recrystallization and Damage Evolution During Thermal Cycling in SAC305 Solder Joints  

SciTech Connect

Because failures in lead-free solder joints occur at locations other than the most highly shear-strained regions, reliability prediction is challenging. To gain physical understanding of this phenomenon, physically based understanding of how elastic and plastic deformation anisotropy affect microstructural evolution during thermomechanical cycling is necessary. Upon solidification, SAC305 (Sn-3.0Ag-0.5Cu) solder joints are usually single or tricrystals. The evolution of microstructures and properties is characterized statistically using optical and orientation imaging microscopy. In situ synchrotron x-ray measurements during thermal cycling are used to examine how crystal orientation and thermal cycling history change strain history. Extensive characterization of a low-stress plastic ball grid array (PBGA) package design at different stages of cycling history is compared with preliminary experiments using higher-stress package designs. With time and thermal history, microstructural evolution occurs mostly from continuous recrystallization and particle coarsening that is unique to each joint, because of the specific interaction between local thermal and displacement boundary conditions and the strong anisotropic elastic, plastic, expansion, and diffusional properties of Sn crystals. The rate of development of recrystallized microstructures is a strong function of strain and aging. Cracks form at recrystallized (random) boundaries, and then percolate through recrystallized regions. Complications arising from electromigration and corrosion are also considered.

Bieler, Thomas R.; Zhou, Bite; Blair, Lauren; Zamiri, Amir; Darbandi, Payam; Pourboghrat, Farhang; Lee, Tae-Kyu; Liu, Kuo-Chuan (Michigan); (Cisco)

2013-04-08

261

Torsion of an indirect hernia sac within a hydrocele causing acute scrotum: case report and review of the literature.  

PubMed

We report a case of acute scrotum in a 2-year-old child caused by torsion of an indirect hernia sac within a hydrocele. This is an extremely rare cause of acute scrotal swelling and pain in the pediatric population, with this case representing only the eighth instance reported in the literature. Despite the scarcity with which this diagnosis has been encountered, clinicians should include torsion of an indirect hernia sac on the differential diagnosis for acute scrotum in a child. PMID:17013626

Tillett, John W; Elmore, James; Smith, Edwin A

2006-12-01

262

Wilms Tumor  

MedlinePLUS

... cells that are destined to form into the kidneys malfunctioning and forming a tumor. Signs and Symptoms Before being diagnosed with Wilms ... IV. Stage V: Cancer is found in both kidneys at diagnosis (also called bilateral tumors). About 5% are stage V. Surgery is most ...

263

Hypothalamic tumor  

MedlinePLUS

... at any age, but they are often more aggressive in adults than in children. In adults, tumors ... The treatment depends on how aggressive the tumor is, and whether it is a glioma or another type of cancer. Treatment may involve combinations of surgery, radiation , ...

264

Genetics of pediatric renal tumors.  

PubMed

Wilms tumor (WT) accounts for approximately 95 % of all pediatric renal tumors, with a peak incidence between 2 and 3 years of age. It occurs in sporadic and congenital forms, the latter often occurring before 1 year of age. Incidence declines with age, and WT rarely is observed in adults. WT is an embryonal tumor of the kidney caused by aberrant proliferation of early metanephric kidney cells. It can arise from more than one developmental error and therefore several subtypes can be defined. WT1, a zinc-finger transcription factor, was identified as the first WT gene. Other genes frequently altered somatically in subsets of WT are CTNNB1 and WTX; both genes influence the Wnt signalling pathway. Imprinting alterations of genes in 11p15 are also observed in a subset of WTs. Other pediatric renal tumors occur less often, e.g. malignant rhabdoid tumor of the kidney, clear-cell sarcoma, desmoplastic small-round-cell tumors, congenital mesoblastic nephroma, renal cell carcinoma of childhood, renal primitive neuroectodermal tumors, renal medullary carcinoma, and synovial sarcoma of the kidney. In most of these, characteristic genetic alterations have been identified that help in the unequivocal diagnosis of these childhood renal cancers that are often difficult to distinguish. PMID:22461142

Royer-Pokora, Brigitte

2013-01-01

265

PRELIMINARY OBSERVATIONS ON THE COST OF PRODUCING FINGERLINGS FROM CHANNEL CATFISH STOCKED AS SAC FRY OR AS HATCHERY-FED SWIM-UP FRY  

Technology Transfer Automated Retrieval System (TEKTRAN)

Some producers stock channel catfish sac fry in nursery ponds as early as two days after hatching to reduce hatchery operating costs associated with the traditional practice of feeding swim-up fry for 7-10 days prior to stocking. This study was conducted to determine if stocking catfish sac fry two...

266

Solutions Network Formulation Report. Reducing Light Pollution in U.S. Coastal Regions Using the High Sensitivity Cameras on the SAC-C and Aquarius/SAC-D Satellites  

NASA Technical Reports Server (NTRS)

Light pollution has significant adverse biological effects on humans, animals, and plants and has resulted in the loss of our ability to view the stars and planets of the universe. Over half of the U.S. population resides in coastal regions where it is no longer possible to see the stars and planets in the night sky. Forty percent of the entire U.S. population is never exposed to conditions dark enough for their eyes to convert to night vision capabilities. In coastal regions, urban lights shine far out to sea where they are augmented by the output from fishing boat, cruise ship and oil platform floodlights. The proposed candidate solution suggests using HSCs (high sensitivity cameras) onboard the SAC-C and Aquarius/SAC-D satellites to quantitatively evaluate light pollution at high spatial resolution. New products modeled after pre-existing, radiance-calibrated, global nighttime lights products would be integrated into a modified Garstang model where elevation, mountain screening, Rayleigh scattering, Mie scattering by aerosols, and atmospheric extinction along light paths and curvature of the Earth would be taken into account. Because the spatial resolution of the HSCs on SAC-C and the future Aquarius/SAC-D missions is greater than that provided by the DMSP (Defense Meteorological Satellite Program) OLS (Operational Linescan System) or VIIRS (Visible/Infrared Imager/Radiometer Suite), it may be possible to obtain more precise light intensity data for analytical DSSs and the subsequent reduction in coastal light pollution.

Andrews, Jane C.; Knowlton, Kelly

2007-01-01

267

Updates on abdominal desmoid tumors  

PubMed Central

Desmoid tumor is a monoclonal, fibroblastic proliferation arising in musculoaponeurotic structures. This connective tissue hyperplasia infiltrates locally, recurs frequently after resection but does not metastasize. Abdominal desmoid occurs sporadically, in association with some familial syndromes and often represents a clinical dilemma for surgeons. The enigmatic biology and anatomical location of abdominal desmoids make treatment recommendations difficult. This distinct pathological entity is reviewed with a specific focus on aetiology and management. PMID:18023087

Rampone, Bernardino; Pedrazzani, Corrado; Marrelli, Daniele; Pinto, Enrico; Roviello, Franco

2007-01-01

268

Pediatric germ cell tumors presenting beyond childhood?  

PubMed

Four cases are reported meeting the criteria of a pediatric (i.e., Type I) testicular germ cell tumor (TGCT), apart from the age of presentation, which is beyond childhood. The tumors encompass the full spectrum of histologies of pediatric TGCT: teratoma, yolk sac tumor, and various combinations of the two, and lack intratubular germ cell neoplasia/carcinoma in situ in the adjacent parenchyma. The neoplasms are (near)diploid, and lack gain of 12p, typical for seminomas and non-seminomas of the testis of adolescents and adults (i.e., Type II). It is proposed that these neoplasms are therefore late appearing pediatric (Type I) TGCT. The present report broadens the concept of earlier reported benign teratomas of the post-pubertal testis to the full spectrum of pediatric TGCT. The possible wide age range of pediatric TGCT, demonstrated in this study, lends credence to the concept that TGCT should according to their pathogenesis be classified into the previously proposed types. This classification is clinically relevant, because Type I mature teratomas are benign tumors, which are candidates for testis conserving surgery, as opposed to Type II mature teratomas, which have to be treated as Type II (malignant) non-seminomas. PMID:25427839

Oosterhuis, J W; Stoop, J A; Rijlaarsdam, M A; Biermann, K; Smit, V T H B M; Hersmus, R; Looijenga, L H J

2014-11-27

269

Thymoma and thymic carcinoma arising in a thymolipoma: report of a unique case.  

PubMed

Thymic carcinoma arising within a thymolipoma has not been reported previously. The authors present a unique case of thymoma and undifferentiated thymic carcinoma arising within a thymolipoma in a 36-year-old woman. The bulk of the resected mass was composed of benign fatty tissue admixed with foci of unremarkable thymic tissue; however, it also harbored a central solid mass showing undifferentiated thymic carcinoma associated with a type B2 thymoma. The carcinoma cells were positive for cytokeratin AE1/AE3, cytokeratin 19, and cytokeratin 8/18. They were negative for vimentin, cytokeratin 7, cytokeratin 20, CD5, epithelial membrane antigen, CD30, placental alkaline phosphatase, carcinoembryonic antigen, CD99, leukocyte common antigen, Epstein-Barr virus, inhibin alpha, and protein gene product 9.5. Rare tumor cells showed positive staining for chromogranin and synaptophysin. PMID:18480395

Haddad, Hussam; Joudeh, Amani; El-Taani, Hani; Mansour, Asem; Morcos, Basem; Fayoumi, Said; Sughayer, Maher

2009-02-01

270

Gastric Cancer Arising from an Upside-Down Stomach through a Paraesophageal Hiatal Hernia  

PubMed Central

We report the rare case of an elderly patient with an advanced gastric cancer arising from an upside-down stomach through a paraesophageal hiatal hernia (PEH). An 82-year-old man presented with appetite loss and anemia. Upper gastrointestinal endoscopy revealed a type 1 tumor located in the middle body of the stomach. An upper gastrointestinal series and computed tomography showed organoaxial rotation of the stomach, which was located in the mediastinum, through a PEH, indicating an upside-down stomach. The preoperative diagnosis was gastric cancer arising from an upside-down stomach through a PEH. The patient underwent total gastrectomy with lymph node dissection and closure of the hernial orifice. Although a large PEH is a chronic disorder, gastric malignancies should be considered in patients with PEH manifested as an upside-down stomach due to its anatomical characteristics, and careful preoperative diagnosis is mandatory. PMID:24761138

Mimatsu, Kenji; Kano, Hisao; Oida, Takatsugu; Kawasaki, Atsushi; Fukino, Nobutada; Kida, Kazutoshi; Kuboi, Youichi; Amano, Sadao

2014-01-01

271

Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma  

ClinicalTrials.gov

Childhood Burkitt Lymphoma; Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Childhood Choroid Plexus Tumor; Childhood Craniopharyngioma; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Medulloepithelioma; Childhood Meningioma; Childhood Mixed Glioma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Childhood Oligodendroglioma; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Childhood Subependymal Giant Cell Astrocytoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Childhood Visual Pathway and Hypothalamic Glioma; Recurrent Childhood Visual Pathway Glioma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Unspecified Childhood Solid Tumor, Protocol Specific

2013-07-01

272

Leiomyosarcoma of Bone Arising in Association with a Bone Infarct  

PubMed Central

Both primary leiomyosarcoma of bone and sarcoma arising in association with a bone infarct are rare events. In this case report we describe for the first time a case of leiomyosarcoma arising in a bone infarct. The tumour arose in a medullary infarct in the proximal femur of an elderly patient. As in other cases of sarcoma arising in a bone infarct, the prognosis was poor, the patient dying within 6 months of diagnosis. PMID:18521345

Petra, M.; Gibbons, C. L. M. H.

2002-01-01

273

Wilms tumor in horseshoe kidneys: radiologic diagnosis  

SciTech Connect

Two cases of nephroblastoma occurring in a horseshoe kidney are reported, and 32 cases from the literature are reviewed. The radiologic signs of horseshoe kidney may be difficult to evaluate with excretory urography when the mass is large. Rotational abnormalities of the opposite kidney that is not involved by tumor should suggest the possibility of an associated horseshoe kidney. Real-time ultrasonography and computed tomography are helpful in identifying the isthmus of the horseshoe kidney. Aortography confirms the presence of the horseshoe kidney and demonstrates the arterial supply to the isthmus and the tumor. Radionuclide scans demonstrate the isthmus when the tumor arises from an upper pole, but may not be diagnostic if the tumor arises from the isthmus.

Gay, B.B. Jr.; Dawes, R.K.; Atkinson, G.O. Jr.; Ball, T.I. Jr.

1983-03-01

274

[Adipocytic tumors].  

PubMed

Adipocytic tumors are the most common mesenchymal neoplasms, liposarcoma accounting for approximately 20% of soft tissue sarcomas. The differential diagnosis between benign and malignant tumors is often problematic and represents a significant proportion of consultation cases. The goal of this article is to review liposarcoma subtypes, the main benign adipocytic neoplasms: lipoblastoma, hibernoma, spindle/pleomorphic cell lipoma, chondroid lipoma, as well as non adipocytic neoplasms with a lipomatous component such as lipomatous solitary fibrous tumor, emphasizing on practical differential diagnosis issues, and immunohistochemical and molecular tools allowing their resolution. PMID:25533918

Stock, Nathalie

2015-01-01

275

Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor.  

PubMed

Well documented examples of primary malignant giant cell tumor of bone (giant cell tumor and concurrent sarcoma arising de novo) are exceedingly rare in the literature. We report a case arising in the left ischium of a 44-yr-old man. He had no previous history of radiation therapy or multiple resections. Histologically, the tumor was a typical giant cell tumor of bone juxtaposed to a malignant fibrous histiocytoma (MFH). The juxtaposition of a high grade sarcoma (MFH) and a locally aggressive nonmalignant neoplasm such as giant cell tumor is analogous to several other tumors of bone and soft tissue in which a low grade malignant or locally aggressive tumor can be associated with MFH or fibrosarcoma de novo, namely chondrosarcoma, chordoma, liposarcoma, and well differentiated intraosseous and parosteal osteosarcoma. The presence of a high grade malignant component in each of the aforementioned neoplasms generally portends a more ominous prognosis, although this is not invariably true. Recognition of the phenomenon of "dedifferentiation" (or tumor progression) in some bone tumors and sarcomas is important to ensure appropriate treatment. Distinction from secondary malignant giant cell tumors which are usually radiation induced is also important, since the latter have a much worse prognosis than those with dedifferentiation occurring de novo. PMID:2554283

Meis, J M; Dorfman, H D; Nathanson, S D; Haggar, A M; Wu, K K

1989-09-01

276

[The case of the nematode Setaria equina found in the vaginal sac of the stallion's scrotum].  

PubMed

The nematode Setaria equina usually reside in body cavities and do not cause clinical symptoms. From time to time, however, these parasites can be located in the scrotum and spermatic cord inflicting pain and edema in these body parts. The aim of the study was to describe the case of the nematode Setaria equina found in the vaginal sac of the stallion's scrotum. During the study, thorough examination of 50 isolated testicles of 25 stallions was conducted. The horses were obtained post-slaughter from the local slaughterhouse near Krakow. In one of examined stallions, two females of Setaria equina of 80 and 110 mm in length were found attached to the surface of the testicle. A part of one of the nematode was found in the space between the surface of the testicle and the epididymis. During the examination of the testicle sections, chronic inflammation (orchitis chronica) and focal necrosis perivascularis were found. PMID:21452525

Korna?, S?awomir; Pozor, Ma?gorzata; Okólski, Adam; Nowosad, Bogus?aw

2010-01-01

277

Comparative Study of Endolymphatic Sac Decompression and Vestibular Neurectomy in Intractable Meniere's Disease.  

PubMed

To comparative study the clinical effect of endolymphatic sac decompression (ELSD) and vestibular neurectomy (VN) in intractable Meniere's disease (MD). The study included 30 MD intractable patients, 21 of which underwent ELSD and nine of which were treated by VN via retrosigmoid approach. Follow-up period ranged from 3 to 6 years. In 21 patients by ELSD, excellent vertigo control and good control were noted in 11 patients (52.4 %) and 4 patients (19.0 %), partial control in 4 and no control in 2 patients. All the 9 patients by VN, vertigo was excellent control. ELSD can improve hearing and tinnitus, but VN not. VN can achieve much better effect in improving vertigo in intractable MD patients. But relative to ELSD, it has much more disadvantages. PMID:25621233

Liu, Yiqing; Han, Jie; Zhou, Xuanchen; Luan, Deheng; Xie, Fengyang; Gao, Kun

2015-03-01

278

Self-Assembly of Large and Small Molecules into Hierarchically Ordered Sacs and Membranes  

NASA Astrophysics Data System (ADS)

We report here the self-assembly of macroscopic sacs and membranes at the interface between two aqueous solutions, one containing a megadalton polymer and the other, small self-assembling molecules bearing opposite charge. The resulting structures have a highly ordered architecture in which nanofiber bundles align and reorient by nearly 90° as the membrane grows. The formation of a diffusion barrier upon contact between the two liquids prevents their chaotic mixing. We hypothesize that growth of the membrane is then driven by a dynamic synergy between osmotic pressure of ions and static self-assembly. These robust, self-sealing macroscopic structures offer opportunities in many areas, including the formation of privileged environments for cells, immune barriers, new biological assays, and self-assembly of ordered thick membranes for diverse applications.

Capito, Ramille M.; Azevedo, Helena S.; Velichko, Yuri S.; Mata, Alvaro; Stupp, Samuel I.

2008-03-01

279

Activity in the Shuttle Action Center (SAC) of the Huntsville Operations Support Center (HOSC)  

NASA Technical Reports Server (NTRS)

Launched on June 20, 1996, the STS-78 mission's primary payload was the Life and Microgravity Spacelab (LMS), which was managed by the Marshall Space Flight Center (MSFC). During the 17 day space flight, the crew conducted a diverse slate of experiments divided into a mix of life science and microgravity investigations. In a manner very similar to future International Space Station operations, LMS researchers from the United States and their European counterparts shared resources such as crew time and equipment. Five space agencies (NASA/USA, European Space Agency/Europe (ESA), French Space Agency/France, Canadian Space Agency /Canada, and Italian Space Agency/Italy) along with research scientists from 10 countries worked together on the design, development and construction of the LMS. This photo was taken in the Shuttle Action Center (SAC) of the Huntsville Operations Support Center (HOSC) Spacelab Payload Operations Control Center (SL POCC) at MSFC during the mission.

1996-01-01

280

Squamous cell carcinoma arising from longstanding colocutaneous fistula: A case report  

PubMed Central

A 60-year-old female patient suffered unhealed wounds over left flank for around 30 years after surgical removal of left renal stones. Fecal material spilled from the two small openings of the scar, bothered her all day long. During the course of the 30 years, she suffered from intermittent fever, diarrhea and wound pain and presented with malnourished condition. After serial examinations, tumor associated with iatrogenic colo-cutaneous fistula was impressed and she received en bloc resection. Pathology revealed squamous cell carcinoma arising from the fistula with colon and spleen invasion. To the best of our knowledge, no such case has been reported, as yet. PMID:16127766

Lee, Yueh-Tsung; Hsu, Sheng-Der; Kuo, Chien-Long; Chou, Dev-Aur; Lin, Mao-Sheng; Huang, Min-Ho; Wu, Hurng-Sheng

2005-01-01

281

Sac-D Aquarius a Satellite for Ocean, Climate and Environment. One Year of Data  

NASA Astrophysics Data System (ADS)

The SAC-D/Aquarius satellite was launched in June 10, 2011. It's a joint mission between Argentina (through CONAE) and US (NASA). This satellite is a true Observatory with a suite of sensors for Earth Observation, its weight is 1400 kg, sun-synchronous orbit at 657 km (6 pm ascendant node), revisit of seven days. Other space agencies have contributed with instruments and support (facilities and ground segment), as CNES, CSI, ASI and AEB/INPE. The primary objective is to monitor global variations in ocean surface salinity (SSS) in order to improve the knowledge about ocean circulation, water cycle and climate. The SSS is performed with Aquarius instrument (NASA). Other oceanic and atmospheric parameters are measured with a MWR, from CONAE, in K and Ka band, as wind speed, rain rate, sea ice, water vapour and liquid water in clouds. The thermal camera (NIRST) estimates sea surface temperature and detect high temperature events (fires and volcanic eruptions). The High Sensitivity Camera (HSC) generates night images (very useful for fishery activity monitoring in the sea, studying of electrical storms, polar auroras and urban application). The DCS (Data Collection System, from CONAE) can receive meteorological and environmental data from ground platforms and distribute among users. The TDP (Technological Demonstration Package, from CONAE) measures different parameters of satellite position and velocity. Other two important instruments are ROSA (from Italy) and CARMEN 1 (from France). The first is an atmospheric sounder, it allows elaborating atmospheric profiles of temperature, pressure and humidity, and the second has detectors for studies of space debris and the effects of radiation on electronic devices. This work provides a review of the first year of data, including the status of calibration and validation, other finding and at the same time we want to present the progress in the active educational and outreach program including the information of SAC-D Aquarius Mission.

Torrusio, S.; Lagerloef, G.; Rabolli, M.; LeVine, D.

2012-07-01

282

Limb and other postcranial skeletal defects induced by amniotic sac puncture in the mouse.  

PubMed Central

A mouse model for studying the teratogenic effects of amniotic sac puncture has recently been established (MacIntyre et al. 1995), and the anomalies encountered included cleft palate, limb and tail abnormalities, and postural deformities. In order to investigate the underlying mechanism(s) involved, mouse embryos subjected to amniotic sac puncture on day 13 of gestation were examined externally on day 19, then 'cleared' and bulk stained with alizarin red S and Alcian blue to reveal, respectively, their bony and cartilaginous elements. This procedure allowed a comparison to be made between the incidence of soft tissue anomalies of the distal parts of the limbs and the appearance of the underlying skeletal elements. Despite a high incidence of soft tissue (principally digital) anomalies, relatively few skeletal anomalies were encountered. Measurements of intact long bones, and regions of ossification, were made in the major long bones of 'nonexperimental' and 'internal' controls and 'experimental' fetuses that displayed external morphological malformations to establish whether the experimental procedure had a greater effect on the proximal or distal components of the limb skeleton. No significant difference was observed when the ratios of proximal: distal length were compared with those obtained from the control series. The degree of severity of 'clubhand' and 'clubfoot' deformity was determined, and a comparison made between the severity observed on the right and left sides. This analysis revealed that for 'clubhand', the left forelimb was more severely affected than the right forelimb. The incidence of 'clubfoot' deformity was similar between the 2 sides. A possible explanation for this asymmetric effect is provided. An unexpected finding was the abnormal pattern of ossification seen in the sternum of two thirds of the 'experimental' fetuses that displayed external morphological malformations. This abnormal pattern was seen in none of the controls nor in fetuses in the 'experimental' series that displayed no external morphological malformations. Images Fig. 1 Fig. 2 Fig. 3 PMID:8771394

Chang, H H; Schwartz, Z; Kaufman, M H

1996-01-01

283

SAC-D/Aquarius MWR sea ice concentration: first results and validation  

NASA Astrophysics Data System (ADS)

The National Space Agency of Argentina (CONAE) developed the SAC-D/Aquarius science mission (launched in June 2011), together with the National Aeronautics and Space Administration (NASA). One of the sensors on board the SAC-D is a MWR (Micro Wave Radiometer). This instrument is a three channel push broom microwave radiometer with 8 antenna beams per channel and two different incident angles (52° and 58°), that provides a measurement swath of approximately 380 Km. These channels provide 36.5 GHz dual horizontal and vertical polarized and 23.8 GHz horizontal polarized radiance measurements in an overlapping swath with the L-band Aquarius radiometer/scatterometer. Geophysical variables over marine surface, such as, columnar water vapor, wind speed, sea ice concentration, and rain rate are generated with the data comming from MWR. It is well recognized that sea ice is the most significant characteristic of the polar ocean environment and influences the Earth's global climate. Some approaches such as the Bootstrap and the NASA Team algorithms have been designed to estimate sea ice concentration and type using microwave emissions. These algorithms rely primarily on the factor that polarization and spectrum are different for sea ice and open ocean. CONAE developed an algorithm with the collaboration of CFRSL (Central Florida Remote Sensing Laboratory) and SHN (Argentine Naval Hydrographic Service), for the sea ice concentration using data coming from MWR radiometer. This algorithm is based on differences between brightness temperatures corresponding to vertical and horizontal polarization of 36.5 GHz band and the gradient corresponding to values of 36.5 and 23.8 GHZ in horizontal polarization. A validation process was implemented with the collaboration of SHN researchers, using the sea ice concentration obtained from National Snow and Ice Data Center (NSIDC) for comparisons. In this work we present the first results of Sea Ice Concentration obtained using the CONAE algorithm for both, north and south poles. In addition, we show the preliminary validation analysis of those estimations.

Barreira, S.; Tauro, C. B.; Masuelli, S.; Salgado, H.; Jones, L.

2012-12-01

284

sAC from aquatic organisms as a model to study the evolution of acid/base sensing.  

PubMed

Soluble adenylyl cyclase (sAC) is poised to play multiple physiological roles as an acid/base (A/B) sensor in aquatic organisms. Many of these roles are probably similar to those in mammals; a striking example is the evolutionary conservation of a mechanism involving sAC, carbonic anhydrase and vacuolar H(+)-ATPase that acts as a sensor system and regulator of extracellular A/B in shark gills and mammalian epididymis and kidney. Additionally, the aquatic environment presents unique A/B and physiological challenges; therefore, sACs from aquatic organisms have likely evolved distinct kinetic properties as well as distinct physiological roles. sACs from aquatic organisms offer an excellent opportunity for studying the evolution of A/B sensing at both the molecular and whole organism levels. Moreover, this information could help understand and predict organismal responses to environmental stress based on mechanistic models.This article is part of a Special Issue entitled "The Role of Soluble Adenylyl Cyclase in Health and Disease," guest edited by J. Buck and L. R. Levin. PMID:24971688

Tresguerres, Martin

2014-12-01

285

Quantification of Cardiac Sac Network Effects on a Movement-Related Parameter of Pyloric Network Output in the Lobster  

E-print Network

Output in the Lobster JEFF B. THUMA AND SCOTT L. HOOPER Neuroscience Program, Department of Biological on a movement-related parameter of pyloric network output in the lobster. J Neurophysiol 89: 745­753, 2003; 10 of cardiac sac activity on the OSF of all pyloric neurons in the lobster, Panulirus interruptus

Hooper, Scott

286

Effect of bile and lipids on the stereoselective metabolism of halofantrine by rat everted-intestinal sacs.  

PubMed

The everted rat intestinal-sac model was utilized to assess the effect of post-prandial conditions on the stereoselective intestinal metabolism of halofantrine to its active metabolite desbutylhalofantrine. Everted intestinal sacs were incubated with (+/-)-halofantrine HCl in the presence of simulated bile solution (containing lecithin, lipase and cholesterol) and lipids to mimic post-prandial conditions in the small intestine. The halofantrine enantiomer concentrations in intestinal sacs were relatively constant in the presence of bile, but decreased significantly on addition of lipids to the incubation media. Formation of desbutylhalofantrine enantiomers was inversely proportional to bile concentration whereas addition of lipids in the presence of bile caused a significant decrease in desbutylhalofantrine:halofantrine ratio of (-) enantiomers. Pre-treatment of rats with peanut oil had no significant effect on desbutylhalofantrine formation in the incubated sacs or microsomal preparations, nor did it affect the expression of intestinal cytochrome P450. Addition of extra cholesterol to the bile incubations caused a significant increase in tissue halofantrine and desbutylhalofantrine concentrations, which as for lower cholesterol, were diminished on addition of other lipids. The results were consistent with previous in vivo evaluations showing that the desbutylhalofantrine to halofantrine ratio was decreased by the ingestion of a high fat meal. PMID:19496124

Patel, Jigar P; Korashy, Hesham M; El-Kadi, Ayman O S; Brocks, Dion R

2010-02-01

287

Fate of the excluded abdominal aortic aneurysm sac: Long-term follow-up of 831 patients  

Microsoft Academic Search

Purpose: Nonresective treatment of the infrarenal abdominal aortic aneurysm by proximal and distal ligation of the aneurysm sac (exclusion) combined with aortic bypass has been previously reported. A 10-year experience with 831 patients undergoing this procedure was reviewed.Methods: From 1984 to 1994, 831 (761 elective, 70 urgent) of 1103 patients being treated for abdominal aortic aneurysm underwent repair with the

Michael Resnikoff; R. Clement Darling; Benjamin B. Chang; William E. Lloyd; Philip S. K. Paty; Robert P. Leather; Dhiraj M. Shah

1996-01-01

288

Evidence of the Most Stretchable Egg Sac Silk Stalk, of the European Spider of the Year Meta menardi  

E-print Network

Evidence of the Most Stretchable Egg Sac Silk Stalk, of the European Spider of the Year Meta silks display generally strong mechanical properties, even if differences between species and within the same species can be observed. While many different types of silks have been tested, the mechanical

Buehler, Markus J.

289

Ultrafast Forwarding Architecture Using a Single Optical Processor for Multiple SAC-Label Recognition Based on FWM  

Microsoft Academic Search

We propose and demonstrate a novel ultrafast label processor that can recognize multiple spectral amplitude coded (SAC) labels using four wave mixing (FWM) sideband allocation and selective optical filtering. Our proposed solution favors hardware simplicity over bandwidth efficiency in order to achieve ultra- fast label recognition at reasonable cost. Our implementation, unlike all other optical label processing techniques, does not

JosÉ Bernardo Rosas-FernÁndez; Simon Ayotte; Leslie A. Rusch; Sophie LaRochelle

2008-01-01

290

Malignant epithelial odontogenic tumors.  

PubMed

Malignant epithelial odontogenic tumors are very rare. They may arise from the epithelial components of the odontogenic apparatus. The rests of Malassez, the reduced enamel epithelium surrounding the crown of an impacted tooth, the rests of Serres in the gingiva, and the linings of odontogenic cysts represent the precursor cells for malignant transformation. Because metastatic carcinoma is the most common malignancy of the jaws, the diagnosis of a primary intraosseous carcinoma must always be made to the exclusion of metastatic disease. Odontogenic carcinomas include malignant (metastasizing) ameloblastoma, ameloblastic carcinoma, primary intraosseous squamous cell carcinoma, clear cell odontogenic carcinoma, and malignant epithelial ghost cell tumor. There are specific histopathologic features that support the diagnosis of a primary carcinoma of odontogenic epithelium which are presented in this article. Immunohistochemical (IHC) staining is important for distinguishing clear cell odontogenic carcinoma from metastatic renal cell tumors, yet IHC stains are not particularly helpful for other lesions in this group-all of which exhibit low molecular weight cytokeratin positivity. Aggressive growth and nodal and distant metastases occur with all of these entities. PMID:10587275

Eversole, L R

1999-11-01

291

Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.  

PubMed

BubR1 acetylation is essential in mitosis. Mice heterozygous for the acetylation-deficient BubR1 allele (K243R/+) spontaneously developed tumors with massive chromosome missegregations. K243R/+ mouse embryonic fibroblasts (MEFs) exhibited a weakened spindle assembly checkpoint (SAC) with shortened mitotic timing. The generation of the SAC signal was intact, as Mad2 localization to the unattached kinetochore (KT) was unaltered; however, because of the premature degradation of K243R-BubR1, the mitotic checkpoint complex disassociated prematurely in the nocodazole-treated condition, suggesting that maintenance of the SAC is compromised. BubR1 acetylation was also required to counteract excessive Aurora B activity at the KT for stable chromosome-spindle attachments. The association of acetylation-deficient BubR1 with PP2A-B56? phosphatase was reduced, and the phosphorylated Ndc80 at the KT was elevated in K243R/+ MEFs. In relation, there was a marked increase of micronuclei and p53 mutation was frequently detected in primary tumors of K243R/+ mice. Collectively, the combined effects of failure in chromosome-spindle attachment and weakened SAC cause genetic instability and cancer in K243R/+ mice. PMID:23878276

Park, Inai; Lee, Hae-ock; Choi, Eunhee; Lee, Yoo-Kyung; Kwon, Mi-Sun; Min, Jaewon; Park, Pil-Gu; Lee, Seonju; Kong, Young-Yun; Gong, Gyungyub; Lee, Hyunsook

2013-07-22

292

Solitary fibrous tumor of the intrathoracic goiter  

PubMed Central

Solitary Fibrous Tumors (SFTs) are rare primary pleural neoplasms which have recently been reported in extra-thoracic sites. In this report, solitary fibrous tumor arising in an intra-thoracic goiter with no evidence of cervical mass in a 74-year-old obese man who was found to have a large superior mediastinal mass with tracheal deviation on Chest X-Ray is presented. PMID:25405117

Vaziri, Mohammad; Molanaei, Saadat; Tamannaei, Zeinab

2014-01-01

293

Primary malignant rhabdoid tumor of the cerebellum  

Microsoft Academic Search

Malignant rhabdoid tumor (MRT) is a recently described variety of childhood renal neoplasm. MRT arising primarily in the\\u000a central nervous system (CNS) is still a rather unfamiliar pathological entity and is frequently misdiagnosed as medulloblastoma\\u000a or primitive neuroectodermal tumor (PNET). We describe a 7-month-old boy who harbored a CNS-MRT that originated within the\\u000a IV ventricle and invaded the brain stem

Juan F. Martínez-Lage; Andrés Nieto; Joaquín Sola; Rosario Domingo; Trinidad R. Costa; Máximo Poza

1997-01-01

294

A Demonstration of the System Assessment Capability (SAC) Rev. 1 Software for the Hanford Remediation Assessment Project  

SciTech Connect

The System Assessment Capability (SAC) is a suite of interrelated computer codes that provides the capability to conduct large-scale environmental assessments on the Hanford Site. Developed by Pacific Northwest National Laboratory for the Department of Energy, SAC models the fate and transport of radioactive and chemical contaminants, starting with the inventory of those contaminants in waste sites, simulating transport through the environment, and continuing on through impacts to the environment and humans. Separate modules in the SAC address inventory, release from waste forms, water flow and mass transport in the vadose zone, water flow and mass transport in the groundwater, water flow and mass transport in the Columbia River, air transport, and human and ecological impacts. The SAC supports deterministic analyses as well as stochastic analyses using a Monte Carlo approach, enabling SAC users to examine the effect of uncertainties in a number of key parameters. The initial assessment performed with the SAC software identified a number of areas where both the software and the analysis approach could be improved. Since that time the following six major software upgrades have been made: (1) An air pathway model was added to support all-pathway analyses. (2) Models for releases from glass waste forms, buried graphite reactor cores, and buried naval reactor compartments were added. (3) An air-water dual-phase model was added to more accurately track the movement of volatile contaminants in the vadose zone. (4) The ability to run analyses was extended from 1,000 years to 10,000 years or longer after site closure. (5) The vadose zone flow and transport model was upgraded to support two-dimensional or three-dimensional analyses. (6) The ecological model and human risk models were upgraded so the concentrations of contaminants in food products consumed by humans are produced by the ecological model. This report documents the functions in the SAC software and provides a number of example applications for Hanford problems. References to theory documents and user guides are provided as well as links to a number of published data sets that support running analyses of interest to Hanford cleanup efforts.

Eslinger, Paul W.; Kincaid, Charles T.; Nichols, William E.; Wurstner, Signe K.

2006-11-06

295

Carcinoid Tumor  

MedlinePLUS

... a roadmap to this full guide. About the endocrine system and endocrine tumors The endocrine system consists of cells that produce hormones. Hormones ... or cells in the body. Part of the endocrine system is the neuroendocrine system, which is made ...

296

Fibroid Tumors  

MedlinePLUS Videos and Cool Tools

... develop from genetic changes in a smooth muscle cell within the myometrium. The cell multiplies to form a tumor. The exact cause ... temperature and break down and destroy the abnormal cells. Other tissues around the fibroid are not affected. ...

297

Pituitary tumor  

MedlinePLUS

... pituitary tumor is an abnormal growth in the pituitary gland. This is the part of the brain that ... are never diagnosed during the person's lifetime. The pituitary gland is a pea-sized endocrine gland located at ...

298

Pituitary Tumors  

MedlinePLUS

... is an abnormal growth of cells within the pituitary gland. Most pituitary tumors are benign, which means they ... of the body; however they can make the pituitary gland produce either too many or too few hormones, ...

299

Pregnancy Tumor  

MedlinePLUS

... Poor oral hygiene (not enough brushing, flossing or cleanings to remove food or plaque) Irritation of the ... of getting a pregnancy tumor. Have regular dental cleanings before you become pregnant. Visit the dentist very ...

300

Effects of breeder age on mineral contents and weight of yolk sac, embryo development, and hatchability in Pekin ducks.  

PubMed

The current study was carried out to investigate the effects of breeder age on egg composition, changes of embryo, yolk sac, and yolk minerals during incubation and hatchability in Pekin ducks. A total of 495 freshly laid eggs were obtained from the same flock of Pekin ducks, aged 28, 34, and 40 wk, and were reared in accordance with the management guide of the duck breeders (Star 53-Grimaud Freres). At each breeder age, egg measurements were made on a random subsample of unincubated eggs. Embryo and yolk sac measurements were made on embryonic day (E) 12, E16, E20, and E25. On d 28 of incubation, the healthy ducklings were removed and sex of chicks was determined. All chicks were weighed and hatching results were determined. Egg weight and yolk percentages increased; however, albumen percentages, shell thickness, and yolk index decreased as the flock aged. Shell percentages, shell breaking strength, albumen index, and haugh units were not affected by breeder age. Also, breeder age affected the Mg, P, K, Ca, Cu, and Zn levels in the yolk, except for Na level on day of setting, and breeder age affected the mineral consumed by embryo during incubation. However, on E25, the levels of examined minerals, except for P level in the yolk sac, were not statistically different in duck breeder age groups. Relative yolk sac and embryo weights of eggs obtained from different breeder ages varied from E16 to E25; however, embryo length was different in breeder age groups from E12 to E20. Hatching weight was affected by breeder age and sex. Hatching results were not different among breeder age groups. This study indicates that breeder age is important for some egg characteristics, relative yolk sac weight, some contents of minerals in the yolk, embryonic growth during incubation, and duckling weight. PMID:24570471

Onbasilar, E E; Erdem, E; Hacan, O; Yalçin, S

2014-02-01

301

Understanding Brain Tumors  

MedlinePLUS

... to Know About Brain Tumors . What is a Brain Tumor? A brain tumor is an abnormal growth? ... Tumors” from Frankly Speaking Frankly Speaking About Cancer: Brain Tumors Download the full book Questions to ask ...

302

32 CFR 537.19 - Demands arising from maritime claims.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 2010-07-01 true Demands arising from maritime claims. 537...BEHALF OF THE UNITED STATES § 537.19 Demands arising from maritime claims. (a) It is essential that Army claims personnel demand payment, or notify the party...

2010-07-01

303

The Plant Cell, Vol. 11, 11791190, June 1999, www.plantcell.org 1999 American Society of Plant Physiologists Sac3, an Snf1-like Serine/Threonine Kinase That Positively and  

E-print Network

Physiologists Sac3, an Snf1-like Serine/Threonine Kinase That Positively and Negatively Regulates the Responses acid sequence of the Sac3 gene product is similar to the catalytic domain of the yeast Snf1 family of serine/threonine kinases and is therefore classified as a Snf1-related kinase (SnRK). Specifically, Sac3

304

Epilepsy associated tumors: Review article  

PubMed Central

Long-term epilepsy associated tumors (LEAT) represent a well known cause of focal epilepsies. Glioneuronal tumors are the most frequent histological type consisting of a mixture of glial and neuronal elements and most commonly arising in the temporal lobe. Cortical dysplasia or other neuronal migration abnormalities often coexist. Epilepsy associated with LEAT is generally poorly controlled by antiepileptic drugs while, on the other hand, it is high responsive to surgical treatment. However the best management strategy of tumor-related focal epilepsies remains controversial representing a contemporary issues in epilepsy surgery. Temporo-mesial LEAT have a widespread epileptic network with complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy LEAT may have an excellent seizure outcome therefore surgical treatment should be offered early, irrespective of pharmacoresistance, avoiding both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of malignant transformation. PMID:25405186

Giulioni, Marco; Marucci, Gianluca; Martinoni, Matteo; Marliani, Anna Federica; Toni, Francesco; Bartiromo, Fiorina; Volpi, Lilia; Riguzzi, Patrizia; Bisulli, Francesca; Naldi, Ilaria; Michelucci, Roberto; Baruzzi, Agostino; Tinuper, Paolo; Rubboli, Guido

2014-01-01

305

Epilepsy associated tumors: Review article.  

PubMed

Long-term epilepsy associated tumors (LEAT) represent a well known cause of focal epilepsies. Glioneuronal tumors are the most frequent histological type consisting of a mixture of glial and neuronal elements and most commonly arising in the temporal lobe. Cortical dysplasia or other neuronal migration abnormalities often coexist. Epilepsy associated with LEAT is generally poorly controlled by antiepileptic drugs while, on the other hand, it is high responsive to surgical treatment. However the best management strategy of tumor-related focal epilepsies remains controversial representing a contemporary issues in epilepsy surgery. Temporo-mesial LEAT have a widespread epileptic network with complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy LEAT may have an excellent seizure outcome therefore surgical treatment should be offered early, irrespective of pharmacoresistance, avoiding both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of malignant transformation. PMID:25405186

Giulioni, Marco; Marucci, Gianluca; Martinoni, Matteo; Marliani, Anna Federica; Toni, Francesco; Bartiromo, Fiorina; Volpi, Lilia; Riguzzi, Patrizia; Bisulli, Francesca; Naldi, Ilaria; Michelucci, Roberto; Baruzzi, Agostino; Tinuper, Paolo; Rubboli, Guido

2014-11-16

306

Tricuspid valve obstruction and right heart failure due to a giant right atrial myxoma arising from the superior vena cava.  

PubMed

Myxomas are the most common primary cardiac tumors. The cardiac myxomas are mostly diagnosed within the atria, and only a few such tumors are reported to have arisen from atrioventricular valves or pulmonary vessels. The authors here present a case of 59-year-old Chinese woman who was hospitalized for exacerbating symptoms of tricuspid stenosis and right heart failure. Echocardiography revealed a giant right atrial myxoma arising from an extremely rare site, the anterior wall of the superior vena cava. With the aid of transesophageal echocardiography, the surgical resection was performed successfully with the patient achieving complete recovery. PMID:24172033

Xiao, Zheng-hua; Hu, Jia; Zhu, Da; Shi, Ying-kang; Zhang, Er-yong

2013-01-01

307

Therapy of a clear cell adenocarcinoma of unknown primary arising in the abdominal wall after cesarean section and after hysterectomy.  

PubMed

Clear cell carcinoma arising in a cesarean section scar is extremely rare. Due to the rarity of the tumor, treatment strategies still need to be further elucidated. We report a case of a woman with a clear cell carcinoma of 10 cm outside the abdominal cavity in her cesarean section scar. Staging surgery revealed two lymph nodes with metastatic dissemination of a clear cell adenocarcinoma. After staging surgery, six cycles of adjuvant chemotherapy with carboplatin/paclitaxel were performed. The patient was disease-free 10 months after completion of chemotherapy. Comprehensive treatment consisting of radical surgery combined with adjuvant chemotherapy can be considered for this uncommon tumor entity. PMID:25301100

Aust, Stefanie; Tiringer, Denise; Grimm, Christoph; Stani, Josefine; Langer, Martin

2014-10-10

308

Epithelial-myoepithelial carcinoma arising in the nasal cavity.  

PubMed

This study documents a case of an epithelial-myoepithelial carcinoma (EMC) in the left nasal cavity. A 70-year-old woman who presented with recurrent epistaxis of the left nasal nostril of 3 months duration was found to have a polypoid tumor in the left nasal cavity. A computed tomography (CT) scan revealed a tumor to occupy the left inferior and middle nasal cavity which had destroyed the inferior nasal turbinate, and a horizontal scan showed the tumor to occupy the middle and posterior nasal cavity. Since the tumor was connected to the lateral wall of the left nasal cavity with a narrow stalk, the tumor was excised by peeling the mucosa from the wall of the left nasal cavity. Based on the histological and immunohistochemical findings, the tumor was diagnosed to be an EMC. The follow-up at 12 months after the operation showed no evidence of recurrence. PMID:18060711

Yamanegi, Koji; Uwa, Nobuhiro; Hirokawa, Mitsuyoshi; Ohyama, Hideki; Hata, Masaki; Yamada, Naoko; Ogino, Koichi; Toh, Kunichika; Terada, Tomonori; Tanaka, Akio; Sakagami, Masafumi; Terada, Nobuyuki; Nakasho, Keiji

2008-09-01

309

From genetic to structural characterization of a new class of RNA-binding domain within the SacY/BglG family of antiterminator proteins.  

PubMed Central

SacY is the prototype of a family of regulatory proteins able to prevent transcription termination. It interacts with a 29 nucleotide RNA sequence able to fold into a stem-loop structure and partially overlapping with a terminator sequence located in the 5' leader mRNA region of the gene it controls. We show here that the N-terminal fragment of SacY, SacY(1-55), and the corresponding fragments of other members of the family have antiterminator activities with efficiency and specificity identical to those of the full-length proteins. In vitro, this activity correlates with the specific affinity of SacY(1-55) for its RNA target. UV melting experiments demonstrate that SacY(1-55) binding stabilizes the RNA target structure. The NMR solution structure of SacY(1-55) is very similar to that obtained in the crystal (van Tilbeurgh et al., 1997): the peptide is folded as a symmetrical dimer without any structural homology with other RNA-binding domains yet characterized. According to a preliminary NMR analysis of the SacY(1-55)-RNA complex, the protein dimer is not disrupted upon RNA binding and several residues implicated in RNA recognition are located at the edge of the dimer interface. This suggests a new mode of protein-RNA interaction. PMID:9305643

Manival, X; Yang, Y; Strub, M P; Kochoyan, M; Steinmetz, M; Aymerich, S

1997-01-01

310

A Case of Chondrosarcoma Arising in the Temporomandibular Joint  

PubMed Central

Chondrosarcoma is a malignant tumor originating in cartilaginous cells. And there are only few reports of the case of chondrosarcoma in temporomandibular joint. We discuss a case of chondrosarcoma in temporomandibular joint in a 28-year-old man. Tumor was in contact with the dura, but en bloc resection was performed. After surgical resection of the tumor, face defect was reconstructed by rectus abdominis-free flap. And there is no recurrence after ten years from the resection.

Shingaki, Susumu; Saito, Chikara

2015-01-01

311

Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades.  

PubMed

The spectrum of testicular tumors and tumor-like lesions that affect young patients (defined for purposes of this article as less than 20 years old) differs significantly from that in an older age group. Although germ cell tumors remain the single largest category, they are a smaller proportion than in adults. Furthermore the pathogenesis and behavior of comparably named germ cell tumors differ depending on whether or not they have developed in prepubertal or postpubertal patients. This is most apparent for the teratomas, which are almost uniformly benign in children but, with some notable exceptions, malignant in the older patients. But even the most common malignant tumor of the testis in children, the yolk sac tumor, despite its identical morphology, lacks the association with other germ cell tumor types, including intratubular germ cell neoplasia, and more aggressive behavior that typify the adult tumors. Among the sex cord-stromal tumors, the juvenile granulosa cell tumor predominates in children, mostly occurs in those under 1-year old, and, for all intents and purposes, is not seen in the postpubertal period. It has a distinctive morphology and, to date, a uniformly benign outcome. There are additional tumors in the sex cord-stromal group that are mostly seen in young patients, including the large cell calcifying Sertoli cell tumor and intratubular large cell hyalinizing Sertoli cell neoplasia. The former is sometimes associated with the Carney syndrome and, to date, all of the latter with the Peutz-Jeghers syndrome. The subtypes of lymphomas and leukemias that involve the testis in children are rare in older patients, and similar remarks pertain to the metastatic tumors, where neuroblastoma (especially) and Wilms? tumor are most common but may be mimicked by primary tumors originating in the paratestis. The pseudoneoplastic lesion, the testicular "tumor" of the adrenogenital syndrome, is usually found in young patients and bears a strong resemblance to the Leydig cell tumor, although there are features that allow its distinction, which is important given its frequently bilateral nature and amenability to medical management through glucocorticoid administration. One of the preferential sites for embryonal rhabdomyosarcoma is the paratestis of young patients, where the spindle cell variant predominates. The melanotic neuroectodermal tumor (retinal anlage tumor) usually occurs in the first year of life, typically involves the epididymis, and uncommonly metastasizes. Occasional cases of the desmoplastic small round cell tumor present in the paratestis of teenagers, and some distinctive tumor-like lesions of the paratestis may also be seen, including meconium periorchitis and splenic-gonadal fusion (occupying both testis and paratestis). These tumors and tumor-like lesions and many others are discussed in this review with the hope it will provide the diagnostic pathologist aid in recognizing the lesions and providing some insight into their clinical significance. PMID:25440720

Ulbright, Thomas M; Young, Robert H

2014-09-01

312

Cancer stem cells in solid tumors: elusive or illusive?  

Microsoft Academic Search

During the past years in vivo transplantation experiments and in vitro colony-forming assays indicated that tumors arise only from rare cells. These cells were shown to bear self-renewal capacities and the ability to recapitulate all cell types within an individual tumor. Due to their phenotypic resemblance to normal stem cells, the term \\

Yvonne Welte; James Adjaye; Hans R Lehrach; Christian RA Regenbrecht

2010-01-01

313

Relative investment in egg load and poison sac in fig wasps: Implications for physiological mechanisms underlying seed and wasp production in figs  

NASA Astrophysics Data System (ADS)

Fig pollinating wasps and most non-pollinator wasps apply secretions from their poison sacs into oviposited flowers that appear necessary to the formation of the galls that their developing offspring consume. Thus, both eggs and poison sac secretions appear to be essential for wasp reproduction, but the relative investment in each is unknown. We measured relative investment in poison sac and egg production in pollinating and non-pollinating wasps associated with seven species of monoecious Panamanian figs representing both active and passive pollination syndromes. We then collected similar data for four fig hosts in China, where some wasp species in the genus Eupristina have lost the ability to pollinate ("cheaters"). All wasps examined possessed large poison sacs, and we found a strong positive correlation between poison sac size and absolute egg production. In the Panamanian species, the relative poison sac to egg investment was highest in the externally ovipositing non-pollinator wasps, followed by active pollinators, then by passive pollinators. Further, pollinator wasps of fig species with demonstrated host sanctions against "cheating" wasps showed higher investment in the poison sac than wasps of species without sanctions. In the Chinese samples, relative investment in the poison sac was indistinguishable between pollinators and "cheaters" associated with the same fig species. We suggest that higher relative investment in poison sac across fig wasp species reflects higher relative difficulty in initiating formation of galls and subsequently obtaining resources from the fig. We discuss the implications for the stability of the fig-wasp mutualism, and for the ability of non-pollinators to exploit this mutualism.

Martinson, Ellen O.; Jandér, K. Charlotte; Peng, Yan-Qiong; Chen, Huan-Huan; Machado, Carlos A.; Arnold, A. Elizabeth; Herre, Edward Allen

2014-05-01

314

Prognosis of Minimally Invasive Carcinoma Arising in Mucinous Cystic Neoplasms of the Pancreas  

PubMed Central

While patients with surgically resected non-invasive mucinous cystic neoplasms (MCNs) of the pancreas are cured, the behavior of surgically resected minimally invasive adenocarcinomas arising in MCN has not been well established. We report 16 surgically resected MCNs with minimal invasion defined as unifocal or multifocal microscopic invasive adenocarcinoma confined to the ovarian stroma of the MCN without capsular or pancreatic parenchymal invasion. Pathological findings were correlated with patient demographics, type of surgery, and long-term follow-up. Our study included 15 females and 1 male ranging in age from 25–66 years. The patients were followed for a mean of 48.6 months (range 12–148 months). The MCNs ranged in size from 3.5–25 cm and were all located in the body/tail of the gland. Lymphovascular invasion was not identified in any of the cases and all lymph nodes were negative for tumor. Ten neoplasms had unifocal invasion, while 6 had multifocal invasion. Twelve of the neoplasms were partially submitted for microscopic examination while 4 were submitted entirely. Only one of the 16 minimally invasive MCNs recurred, and that tumor had been minimally sampled pathologically. Our study demonstrates that the majority of patients with minimally invasive adenocarcinoma arising in MCN are cured by surgery, particularly if the neoplasms are completely examined histologically. PMID:23388125

Lewis, Gloria H.; Wang, Huamin; Bellizzi, Andrew M.; Klein, Alison P.; Askin, Frederic B.; Schwartz, Lauren Ende; Schulick, Richard D.; Wolfgang, Christopher L.; Cameron, John L.; O’Reilly, Eileen M.; Yu, Kenneth H.; Hruban, Ralph H.

2012-01-01

315

Prognosis of minimally invasive carcinoma arising in mucinous cystic neoplasms of the pancreas.  

PubMed

Although patients with surgically resected noninvasive mucinous cystic neoplasms (MCNs) of the pancreas are cured, the behavior of surgically resected minimally invasive adenocarcinomas arising in MCN has not been well established. We report 16 surgically resected MCNs with minimal invasion defined as unifocal or multifocal microscopic invasive adenocarcinoma confined to the ovarian stroma of the MCN without capsular or pancreatic parenchymal invasion. Pathologic findings were correlated with patient demographics, type of surgery, and long-term follow-up. Our study included 15 women and 1 man ranging in age from 25 to 66 years. The patients were followed up for a mean of 48.6 months (range, 12 to 148 mo). The MCNs ranged in size from 3.5 to 25 cm and were all located in the body/tail of the gland. Lymphovascular invasion was not identified in any of the cases, and all lymph nodes were negative for tumor. Ten neoplasms had unifocal invasion, whereas 6 had multifocal invasion. Twelve of the neoplasms were partially submitted for microscopic examination, whereas 4 were submitted entirely. Only 1 of the 16 minimally invasive MCNs recurred, and that tumor had been lighlty sampled pathologically. Our study demonstrates that the majority of patients with minimally invasive adenocarcinoma arising in MCNs are cured by surgery, particularly if the neoplasms are completely examined histologically. PMID:23388125

Lewis, Gloria H; Wang, Huamin; Bellizzi, Andrew M; Klein, Alison P; Askin, Frederic B; Schwartz, Lauren Ende; Schulick, Richard D; Wolfgang, Christopher L; Cameron, John L; O'Reilly, Eileen M; Yu, Kenneth H; Hruban, Ralph H

2013-04-01

316

[Temporomandibular joint primitive tumors and pseudo tumors].  

PubMed

The temporomandibular joint (TMJ) can be the site of bone, cartilaginous, or synovial tumors. There is no well-defined histological classification. We listed all benign tumors, malignant primitive tumors, and rare pseudo tumors of the TMJ. We provide a list to help for the diagnosis and the differential diagnosis of non-tumoral lesions by far the most frequent. PMID:23711211

Oukabli, M; Chibani, M; Ennouali, H; Hemmaoui, B; Albouzidi, A

2013-02-01

317

Localised fibrous mesothelioma arising in an intralobar pulmonary sequestration  

Microsoft Academic Search

A localised fibrous mesothelioma arising from an intralobar lung sequestration occurred in a 64 year old Turkish woman. This appears to be the first report of a mesothelioma occurring within a pulmonary sequestration.

N Paksoy; A Demircan; M Altiner; M Artvinli

1992-01-01

318

EVA Tutorial #3 ISSUES ARISING IN EXTREME VALUE ANALYSIS  

E-print Network

1 EVA Tutorial #3 ISSUES ARISING IN EXTREME VALUE ANALYSIS Rick Katz Institute for Mathematics as limiting distribution of maxima X1, X2, . . ., Xn independent with common cdf F Mn = max{ X1, X2, . . ., Xn

Katz, Richard

319

Sex differences in children's speech arising from the experimental design  

E-print Network

SEX DIFFERENCES IN CHILDREN'S SPEECH ARISING FROM THE EXPERIMENTAL DESIGN A Thesis CONNIE JO WALTERS Submitted to the Graduate College of Texas ARM University in Partial fulfillment of the requirement for the degree of MASTER OF SCIENCE... August 1979 Major Subject: Psychology SEX DIFFERENCES IN CHILDREN'S SPEECH ARISING FROM THE EXPERIMENTAL DESIGN A Thesis by CONNIE JO WALTERS Approved as to style and content by, (Chairman of Committee) (Member) (Member) (Membe (Head...

Walters, Connie Jo

2012-06-07

320

Percutaneous discal cyst rupture in a professional football player using sublaminar epidural injection for thecal sac displacement.  

PubMed

A case of percutaneous discal cyst rupture in a 25-year-old professional American football player is reported. The patient presented with a 3-day history of severe left-sided back pain. Magnetic resonance imaging examination demonstrated a discal cyst effacing the left L4-L5 lateral recess, with interposed thecal sac. A sublaminar epidural injection was performed displacing the thecal sac, exposing the discal cyst, and allowing for percutaneous perforation. The patient had complete resolution of symptoms after discal cyst rupture and was able to compete in a professional football game 3 days later. Computed tomography-guided percutaneous rupture is a therapeutic modality that may be considered for treatment of a symptomatic discal cyst. PMID:25541445

Friedman, Michael V; Park, Andrew; Bumpass, David; Jennings, Jack W; Matava, Matthew J

2015-01-01

321

Motor control of sound frequency in birdsong involves the interaction between air sac pressure and labial tension  

PubMed Central

Frequency modulation is a salient acoustic feature of birdsong. Its control is usually attributed to the activity of syringeal muscles, which affect the tension of the labia responsible for sound production. We use experimental and theoretical tools to test the hypothesis that for birds producing tonal sounds such as domestic canaries (Serinus canaria), frequency modulation is determined by both the syringeal tension and the air sac pressure. For different models, we describe the structure of the isofrequency curves, which are sets of parameters leading to sounds presenting the same fundamental frequencies. We show how their shapes determine the relative roles of syringeal tension and air sac pressure in frequency modulation. Finally, we report experiments that allow us to unveil the features of the isofrequency curves. PMID:24730873

Alonso, Rodrigo; Goller, Franz; Mindlin, Gabriel B.

2014-01-01

322

The effect of temperature on embryonic and yolk-sac larval development in the burbot Lota lota.  

PubMed

The present study investigated the effect of various temperature regimes on embryonic and yolk-sac larval development of the burbot Lota lota. At constant temperature regimes a high percentage of ready-to-hatch embryos, hatched larvae and normally shaped larvae was observed at the lowest temperature (2° C), which significantly decreased with increasing temperatures (4 and 6° C). No larvae hatched at 9° C. The stream temperature regime had no effect on the percentage of ready-to-hatch embryos, but significantly decreased the percentage of hatched larvae and of normally shaped larvae. The lake temperature regime did not affect the viability variables. Also an abrupt temperature increase from 2 to 4° C after 8 days and from 2 to 9° C after 48 days had no effect on the evaluated viability variables. For yolk-sac larvae no temperature related mortalities or abnormalities were observed between 2 and 9° C. PMID:22880731

Lahnsteiner, F; Kletzl, M; Weismann, T

2012-08-01

323

Take time to smell the frogs: vocal sac glands of reed frogs (Anura: Hyperoliidae) contain species-specific chemical cocktails  

PubMed Central

Males of all reed frog species (Anura: Hyperoliidae) have a prominent, often colourful, gular patch on their vocal sac, which is particularly conspicuous once the vocal sac is inflated. Although the presence, shape, and form of the gular patch are well-known diagnostic characters for these frogs, its function remains unknown. By integrating biochemical and histological methods, we found strong evidence that the gular patch is a gland producing volatile compounds, which might be emitted while calling. Volatile compounds were confirmed by gas chromatography–mass spectrometry in the gular glands in 11 species of the hyperoliid genera Afrixalus, Heterixalus, Hyperolius, and Phlyctimantis. Comparing the gular gland contents of 17 specimens of four sympatric Hyperolius species yielded a large variety of 65 compounds in species-specific combinations. We suggest that reed frogs might use a complex combination of at least acoustic and chemical signals in species recognition and mate choice. PMID:24277973

STARNBERGER, IRIS; POTH, DENNIS; PERAM, PARDHA SARADHI; SCHULZ, STEFAN; VENCES, MIGUEL; KNUDSEN, JETTE; BAREJ, MICHAEL F.; RÖDEL, MARK-OLIVER; WALZL, MANFRED; HÖDL, WALTER

2013-01-01

324

AUTORADIOGRAPHIC STUDY OF SUGAR AND AMINO ACID ABSORPTION BY EVERTED SACS OF HAMSTER INTESTINE  

PubMed Central

Autoradiographs were prepared from frozen sections of everted sacs of hamster jejunum which had been incubated in vitro with C14- or H3-labeled sugars and amino acids. When such tissue was incubated in 1 mM solutions of L-valine or L-methionine, columnar absorptive cells at tips of villi accumulated these amino acids to concentrations ranging from 5 to 50 millimoles per liter of cells. Quantitative data were obtained by microdensitometry of C14 autoradiographs. Similar, though less striking, results were obtained with the sugars: galactose, 3-0-methylglucose, ?-methylglucoside, and 6-deoxyglucose. In all cases the marked "step-up" in concentration occurred near the brush border of the cell, and a "step-down" in concentration occurred at the basal pole of the cell. Known inhibitors of intestinal absorption, e.g., phlorizin in the case of sugars, blocked the concentrative step at the luminal border of the absorptive cell. It is inferred from these data that active transport systems for sugars and amino acids reside in the brush border region of the cell. Additional evidence suggests that the basal membrane of the cell may be the site of both a diffusion barrier and a weak transport system directed into the cell. PMID:19866662

Kinter, William B.; Wilson, T. Hastings

1965-01-01

325

Yolk-sac–derived macrophages regulate fetal testis vascularization and morphogenesis  

PubMed Central

Organogenesis of the testis is initiated when expression of Sry in pre-Sertoli cells directs the gonad toward a male-specific fate. The cells in the early bipotential gonad undergo de novo organization to form testis cords that enclose germ cells inside tubules lined by epithelial Sertoli cells. Although Sertoli cells are a driving force in the de novo formation of testis cords, recent studies in mouse showed that reorganization of the vasculature and of interstitial cells also play critical roles in testis cord morphogenesis. However, the mechanism driving reorganization of the vasculature during fetal organogenesis remained unclear. Here we demonstrate that fetal macrophages are associated with nascent gonadal and mesonephric vasculature during the initial phases of testis morphogenesis. Macrophages mediate vascular reorganization and prune errant germ cells and somatic cells after testis architecture is established. We show that gonadal macrophages are derived from primitive yolk-sac hematopoietic progenitors and exhibit hallmarks of M2 activation status, suggestive of angiogenic and tissue remodeling functions. Depletion of macrophages resulted in impaired vascular reorganization and abnormal cord formation. These findings reveal a previously unappreciated role for macrophages in testis morphogenesis and suggest that macrophages are an intermediary between neovascularization and organ architecture during fetal organogenesis. PMID:24912173

DeFalco, Tony; Bhattacharya, Indrashis; Williams, Alyna V.; Sams, Dustin M.; Capel, Blanche

2014-01-01

326

Development of Multi-Service (MS) for SAC-OCDMA systems  

NASA Astrophysics Data System (ADS)

A Multi-Service Optical Code Division Multiple Access (MS-OCDMA) code based on Spectral Amplitude Coding (SAC) is proposed in this paper. The advantage of proposed code on setting a variable number of users in a basic code matrix with a fixed code weight makes it more flexible in generating codewords. The appropriate quality of service required for various network applications can be provided by choosing a different number of users for the basic code matrix of MS code. The properties of the proposed code is compared with other OCDMA codes in terms of code length and maximum cross-correlation. The performance of the MS code mathematically analysed and probability of error for users is plotted as a function of the number of active users and optical received power. Shot, phase induced intensity and thermal noises are considered in mathematical analysis. Results show that by choosing code weight of 4 and optimizing number of users per sequence, the MS code supports up to 82 users, each operating at a bit-rate of 622 Mbps with reference to the Bit Error Rate (BER) of 10-9.

Kakaee, Majid H.; Seyedzadeh, Saleh; Adnan Fadhil, Hilal; Barirah Ahmad Anas, Siti; Mokhtar, Makhfudzah

2014-08-01

327

[An implantable micro-device using wireless power transmission for measuring aortic aneurysm sac pressure].  

PubMed

In order to detect endoleaks after endovascular aneurysm repair (EVAR), we developed an implantable micro-device based on wireless power transmission to measure aortic aneurysm sac pressure. The implantable micro-device is composed of a miniature wireless pressure sensor, an energy transmitting coil, a data recorder and a data processing platform. Power transmission without interconnecting wires is performed by a transmitting coil and a receiving coil. The coupling efficiency of wireless power transmission depends on the coupling coefficient between the transmitting coil and the receiving coil. With theoretical analysis and experimental study, we optimized the geometry of the receiving coil to increase the coupling coefficient. In order to keep efficiency balance and satisfy the maximizing conditions, we designed a closed loop power transmission circuit, including a receiving voltage feedback module based on wireless communication. The closed loop improved the stability and reliability of transmission energy. The prototype of the micro-device has been developed and the experiment has been performed. The experiments showed that the micro-device was feasible and valid. For normal operation, the distance between the transmitting coil and the receiving coil is smaller than 8cm. Besides, the distance between the micro-device and the data recorder is within 50cm. PMID:24059044

Guo, Xudong; Ge, Bin; Wang, Wenxing

2013-08-01

328

Impact of new technology weapons on SAC (Strategic Air Command) conventional air operations. Research report  

SciTech Connect

Chapter I introduces the issue of conventional-response capability. The point stressed first is that the strategic bomber's primary mission is in support of the single integrated operations plan (SIOP) as a nuclear weapons delivery vehicle. However, as cited by Secretary of Defense Caspar Weinberger, we must have a rapid deployment conventional capability to areas where there are small if any U.S. forces present. The SAC strategic projection force (SPF) is available but with gravity weapons of World War II vintage. New technology can provide answers to the problem by providing highly accurate long-range conventional standoff weapons. Chapter II gives a basic historical perspective on the use of the strategic bomber in past wars. It discusses the development of strategy, weapons, and targets in World War II, Korean War, and Vietnam War. Chapter III presents a very brief look at current US policy, strategy, and guidance. Chapter IV covers the aircraft attrition issue in today's highly lethal defensive environment. Chapter V describes the development of air-to-ground weapons. Chapter VI addresses the potential for the future in the shifting balance of Soviet and US technology. The final chapter makes the point that a decision must be made on weapons-acquisition programs and bomber force structure. New technology-standoff conventional weapons could make AAA and SAM defenses a modern Maginot Line.

Bodenheimer, C.E.

1983-06-01

329

Molecular phylogeny and biogeography of air sac catfishes of the Heteropneustes fossilis species complex (Siluriformes: Heteropneustidae).  

PubMed

The air sac catfish, Heteropneustes fossilis (Siluriformes: Heteropneustidae), is widely distributed in freshwaters of the Indian subcontinent and mainland southeast Asia. No comprehensive molecular studies that cover the broad distributional areas have been carried out to date. Here, we conducted molecular phylogenetic analyses using both mitochondrial and nuclear gene sequences to suggest that the Heteropneustes fossilis species complex consists of three clades that may potentially be separate species with distinct geographical distribution (southeast Asia, northeastern India, and southwestern India). The first and second clades are more closely related to each other than they are to the third clade. Within the first clade there is a basal divergence of a subclade consisting of individuals from the Upper Irrawaddy River basin of Myanmar, which share some morphological traits with members of the Indian clades. Our molecular and morphological data are congruent with hypotheses that the Early-Middle Miocene disconnection between the paleo-Tsangpo River and the Irrawaddy River caused the vicariant divergence between southeast Asian and northeastern Indian clades, and that the southeast Asian Heteropneustes originated from the Upper Irrawaddy. PMID:24875251

Ratmuangkhwang, Sahat; Musikasinthorn, Prachya; Kumazawa, Yoshinori

2014-10-01

330

Apospory appears to accelerate onset of meiosis and sexual embryo sac formation in sorghum ovules  

PubMed Central

Background Genetically unreduced (2n) embryo sacs (ES) form in ovules of gametophytic apomicts, the 2n eggs of which develop into embryos parthenogenetically. In many apomicts, 2n ES form precociously during ovule development. Whether meiosis and sexual ES formation also occur precociously in facultative apomicts (capable of apomictic and sexual reproduction) has not been studied. We determined onset timing of meiosis and sexual ES formation for 569 Sorghum bicolor genotypes, many of which produced 2n ES facultatively. Results Genotype differences for onset timing of meiosis and sexual ES formation, relative to ovule development, were highly significant. A major source of variation in timing of sexual germline development was presence or absence of apomictic ES, which formed from nucellar cells (apospory) in some genotypes. Genotypes that produced these aposporous ES underwent meiosis and sexual ES formation precociously. Aposporous ES formation was most prevalent in subsp. verticilliflorum and in breeding lines of subsp. bicolor. It was uncommon in land races. Conclusions The present study adds meiosis and sexual ES formation to floral induction, apomictic ES formation, and parthenogenesis as processes observed to occur precociously in apomictic plants. The temporally diverse nature of these events suggests that an epigenetic memory of the plants' apomixis status exists throughout its life cycle, which triggers, during multiple life cycle phases, temporally distinct processes that accelerate reproduction. PMID:21223576

2011-01-01

331

Integrated Phase Array Antenna/Solar Cell System for Flexible Access Communication (IA/SAC)  

NASA Technical Reports Server (NTRS)

This paper describes recent efforts to integrate advanced solar cells with printed planar antennas. Several previous attempts have been reported in the literature, but this effort is unique in several ways. It uses Gallium Arsenide (GaAs) multi-junction solar cell technology. The solar cells and antennas will be integrated onto a common GaAs substrate. When fully implemented, IA/SAC will be capable of dynamic beam steering. In addition, this program targets the X-band (8 - 12 GHz) and higher frequencies, as compared to the 2.2 - 2.9 GHz arrays targeted by other organizations. These higher operating frequencies enable a greater bandwidth and thus higher data transfer rates. The first phase of the effort involves the development of 2 x 2 cm GaAs Monolithically Integrated Modules (MIM) with integrated patch antennas on the opposite side of the substrate. Subsequent work will involve the design and development of devices having the GaAs MIMs and the antennas on the same side of the substrate. Results from the phase one efforts will be presented.

Clark, E. B.; Lee, R. Q.; Pal, A. T.; Wilt, D. M.; McElroy, B. D.; Mueller, C. H.

2005-01-01

332

Mass-marking of otoliths of lake trout sac fry by temperature manipulation  

USGS Publications Warehouse

The otoliths of 676,000 sac fry of lake trout Salvelinus namaycush in 1986, and of 1,100,000 in 1987, were marked by daily manipulation of water temperature. The fish were stocked into Lake Huron in the spring. Otolith marks consisted of groups of daily growth rings accentuated into recognizable patterns by steadily raising and lowering the temperature about 10 degrees C (from a base of 1-4 degrees C) over 14 h. In 1987, groups of marked and control fish were held for 6 months. The otoliths were removed from samples of the fish, embedded in epoxy, thin sectioned by grinding in the sagittal plane, etched, and viewed by using a combination of a compound microscope (400-1000x) and a video enhancement system. One or more readable otolith sections were obtained from 39 of a sample of 40 fish. Three independent readers examined 41 otoliths for marks and correctly classified the otoliths, with accuracies of 85, 98, and 100%, as being from marked or unmarked fish. The exact number of rings in a recognizable pattern sometimes differed from the number of temperature cycles to which the fish were exposed. Counts of daily rings within groups of six rings varied less than counts within groups of rings.

Bergstedt, Roger A.; Eshenroder, Randy L.; Bowen, Charles; Seelye, James G.; Locke, Jeffrey C.

1990-01-01

333

Mass-marking of otoliths of lake trout sac fry by temperature manipulation  

USGS Publications Warehouse

The otoliths of 676,000 sac fry of lake trout Salvelinus namaycush in 1986, and of 1,100,000 in 1987, were marked by daily manipulation of water temperature. The fish were stocked into Lake Huron in the spring. Otolith marks consisted of groups of daily growth rings accentuated into recognizable patterns by steadily raising and lowering the temperature about IOA?C (from a base of 1-4A?C) over 14h. In 1987, groups of marked and control fish were held for 6 months. The otoliths were removed from samples of the fish, embedded in epoxy, thin-sectioned by grinding in the sagittal plane, etched, and viewed by using a combination of a compound microscope (400-1000x) and a video enhancement system. One or more readable otolith sections were obtained from 39 of a sample of 40 fish. Three independent readers examined 41 otoliths for marks and correctly classified the otoliths, with accuracies of 85, 98,and 100%, as being from marked or unmarked fish. The exact number of rings in a recognizable pattern sometimes differed from the number of temperature cycles to which the fish were exposed. Counts of daily rings within groups of six rings varied less than counts within groups of three rings.

Bergstedt, R.A.; Eshenroder, R.L.; Bowen, C. II; Seelye, J.G.; Locke, J.C.

1990-01-01

334

HoxB4 Confers Definitive Lymphoid-Myeloid Engraftment Potential on Embryonic Stem Cell and Yolk Sac Hematopoietic Progenitors  

Microsoft Academic Search

The extent to which primitive embryonic blood progenitors contribute to definitive lymphoid-myeloid hematopoiesis in the adult remains uncertain. In an effort to characterize factors that distinguish the definitive adult hematopoietic stem cell (HSC) and primitive progenitors derived from yolk sac or embryonic stem (ES) cells, we examined the effect of ectopic expression of HoxB4, a homeotic selector gene implicated in

Michael Kyba; Rita C. R. Perlingeiro; George Q. Daley

2002-01-01

335

Support to Aviation Control Service (SACS): an online service for near-real-time satellite monitoring of volcanic plumes  

NASA Astrophysics Data System (ADS)

Volcanic eruptions emit plumes of ash and gases into the atmosphere, potentially at very high altitudes. Ash-rich plumes are hazardous for airplanes as ash is very abrasive and easily melts inside their engines. With more than 50 active volcanoes per year and the ever-increasing number of commercial flights, the safety of airplanes is a real concern. Satellite measurements are ideal for monitoring global volcanic activity and, in combination with atmospheric dispersion models, to track and forecast volcanic plumes. Here we present the Support to Aviation Control Service (SACS, sacs.aeronomie.be/ecosystem"_target="blank">http://sacs.aeronomie.be/ecosystem), which is a free online service initiated by the European Space Agency (ESA) for the near-real-time (NRT) satellite monitoring of volcanic plumes of SO2 and ash. It combines data from three ultraviolet (UV)-visible and three infrared (IR) spectrometers. The UV-vis sensors are the Ozone Monitoring Instrument (OMI) and the Global Ozone Monitoring Experiment-2 (GOME-2) on-board the two polar orbiting meteorological satellites (MetOp-A & MetOp-B) operated by the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT). The IR sensors are the Atmospheric InfraRed Sounder (AIRS) and the Infrared Atmospheric Sounding Interferometer (IASI) on-board MetOp-A & MetOp-B. This new multi-sensor warning system of volcanic emissions is based on the selective detection of SO2 and ash. This system is optimised to avoid false alerts while at the same time limiting the number of notifications in case of large plumes. A successful rate with more than 95% of notifications corresponding to true volcanic activity is obtained by the SACS system.

Brenot, H.; Theys, N.; Clarisse, L.; van Geffen, J.; van Gent, J.; Van Roozendael, M.; van der A, R.; Hurtmans, D.; Coheur, P.-F.; Clerbaux, C.; Valks, P.; Hedelt, P.; Prata, F.; Rasson, O.; Sievers, K.; Zehner, C.

2014-05-01

336

The accuracy of the rectovaginal examination in detecting cul-de-sac disease in patients under general anaesthesia  

Microsoft Academic Search

BACKGROUND: The rectovaginal examination is frequently used as an adjunct to a bimanual examination. The accuracy of rectovaginal examination in detecting cul-de-sac disease under ideal circumstances of the operating room was studied. METHODS: Fifty-two attending physicians and 30 residents were selected on experience and immediate availability to evaluate the presence of uterosacral nodularity and external rectal compression on 140 women

K. G. Dragisic; L. A. Padilla; M. P. Mila

2003-01-01

337

Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase  

PubMed Central

In the Golgi apparatus, lipid homeostasis pathways are coordinated with the biogenesis of cargo transport vesicles by phosphatidylinositol 4-kinases (PI4Ks) that produce phosphatidylinositol 4-phosphate (PtdIns4P), a signaling molecule that is recognized by downstream effector proteins. Quantitative analysis of the intra-Golgi distribution of a PtdIns4P reporter protein confirms that PtdIns4P is enriched on the trans-Golgi cisterna, but surprisingly, Vps74 (the orthologue of human GOLPH3), a PI4K effector required to maintain residence of a subset of Golgi proteins, is distributed with the opposite polarity, being most abundant on cis and medial cisternae. Vps74 binds directly to the catalytic domain of Sac1 (KD = 3.8 ?M), the major PtdIns4P phosphatase in the cell, and PtdIns4P is elevated on medial Golgi cisternae in cells lacking Vps74 or Sac1, suggesting that Vps74 is a sensor of PtdIns4P level on medial Golgi cisternae that directs Sac1-mediated dephosphosphorylation of this pool of PtdIns4P. Consistent with the established role of Sac1 in the regulation of sphingolipid biosynthesis, complex sphingolipid homeostasis is perturbed in vps74? cells. Mutant cells lacking complex sphingolipid biosynthetic enzymes fail to properly maintain residence of a medial Golgi enzyme, and cells lacking Vps74 depend critically on complex sphingolipid biosynthesis for growth. The results establish additive roles of Vps74-mediated and sphingolipid-dependent sorting of Golgi residents. PMID:22553352

Wood, Christopher S.; Hung, Chia-Sui; Huoh, Yu-San; Mousley, Carl J.; Stefan, Christopher J.; Bankaitis, Vytas; Ferguson, Kathryn M.; Burd, Christopher G.

2012-01-01

338

Lymph flux rates from various lymph sacs in the cane toad Rhinella marina: an experimental evaluation of the roles of compliance, skeletal muscles and the lungs in the movement of lymph.  

PubMed

A new method for quantitatively determining lymph flux from various lymphatic sacs of an anuran, the cane toad, was developed. This method used the dye dilution principle of C(i)V(i)=C(f)V(f) following injection of Evans Blue into specific lymph sacs and measuring its appearance in the venous circulation. The apparent lymph volume was 57 ml kg(-1). The greatest rate of lymph return (0.5-0.8 ml kg(-1) min(-1)) and best linear fit of Evans Blue appearance in the circulation with time followed injections into the subvertebral lymph sac, which has direct connections to both the anterior and posterior pairs of lymphatic hearts. Rate of lymph flux from the pair of posterior lymph hearts was three times greater than the anterior pair. Rates of lymph flux were only influenced by injection volume in the crural lymph sacs, implicating lymph sac compliance as the source of the pressure for lymph movement from these sacs. Femoral lymph sac fluxes were decreased by 60% following ablation of the tendons of the sphincter ani cloacalis, abdominal crenators and piriformis. This supports a role for these muscles in generating the pressure for vertical lymph movement. Femoral lymph sac fluxes were also decreased by 70% by the insertion of a coil in the subvertebral lymph sac, preventing normal compression and expansion of this sac by the lungs. This supports a role for lung ventilation in generating the pressure for vertical movement of lymph. Contrary to previous hypotheses, fluxes from the brachial sac were not influenced by insertion of the coil into the subvertebral sac. A haemorrhage equivalent to 50% of the blood volume did not change lymph flux rates from the femoral lymph sacs. These data provide the first experimental evidence that actual lymph fluxes in the cane toad Rhinella marina depend on lymph sac compliance, contraction of specific skeletal muscles and lung ventilation to move lymph laterally and vertically to the dorsally located lymphatic hearts. PMID:20802118

Hillman, Stanley S; Hedrick, Michael S; Drewes, Robert C; Withers, Philip C

2010-09-15

339

[Malignant nail tumors].  

PubMed

Because of the large number of different tissues making up the distal phalanx of fingers and toes, a large variety of malignant tumors can be found in and around the nail apparatus. Bowen disease is probably the most frequent nail malignancy. It is usually seen as a verrucous plaque of the nail fold and nail bed in persons above the age of 40 years. It slowly grows over a period of years or even decades before degenerating to an invasive squamous cell carcinoma. The latter may also occur primarily often as a weeping onycholysis. The next most frequent nail malignancy is ungual melanoma. Those arising from the matrix are usually pigmented and often start with a longitudinal melanonychia whereas those originating from the nail bed remain amelanotic, are often nodular and mistaken for an ingrown nail in an elderly person. The treatment of choice for in situ and early invasive subungual melanomas is generous extirpation of the nail apparatus whereas distal amputation is only indicated for advanced melanomas. In addition to these frequent nail malignancies, nail-specific carcinomas, malignant vascular and osseous tumors, other sarcomas, nail involvement in malignant systemic disorders and metastases may occur. In most cases, they cannot be diagnosed accurately on clinical grounds. Therefore, a high degree of suspicion is necessary in all isolated or single-digit proliferations that do not respond to conservative treatment. PMID:24718507

Haneke, E

2014-04-01

340

A rare posterior cranial fossa tumor.  

PubMed

Among tumors of the central nervous system, tumors of the mixed glioneuronal type form an important recognized subset. Some of the examples for mixed glioneuronal tumors include gangliocytoma, dysembryoplastic neuroepithelial tumor (DNT), ganglioglioma, anaplastic ganglioglioma, and central neurocytoma. The rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a new entity that has only slowly emerged in the literature due to its prior classification with other low-grade mixed glial and neuronal tumors. These tumors are relatively infrequent lesions, and therefore, they can be challenging to diagnose for the practicing pathologist. This is a rare biphasic tumor with clearly defined neurocytic and glial components. The tumor is found exclusively in the posterior fossa, where it arises in the midline, usually occupying a substantial fraction of the fourth ventricle, and it is observed by magnetic resonance imaging (MRI) as a circumscribed, solid mass with heterogeneous contrast enhancement. We describe here a case of RGNT occurring in a 22-year-old male. PMID:23361291

Nandeesh, Bevinahalli N; Chabra, Manmeet Singh; Babu, Manjaly K; Chand, Ashish K

2012-01-01

341

Percutaneous Treatment of an Infected Aneurysmal Sac Secondary to Aortoesophageal Fistula with a History of Stent-Graft Treatment for Thoracic Aortic Aneurysm  

SciTech Connect

A 68-year-old man who was subjected to stent-grafting of a descending thoracic aortic aneurysm (TAA) 4 months previously was admitted to our hospital with constitutional symptoms, including high fever, sweating, nausea, vomiting, weight loss, and backache. An infected aneurysmal sac was suspected based on computed tomography (CT) findings, and an aortoesophageal fistula (AEF) was identified during esophagoscopy. CT-guided aspiration was performed using a 20-G Chiba needle, confirming the presence of infection. For treatment of the infected aneurysmal sac, CT-guided percutaneous catheter drainage in a prone position was performed under general anesthesia with left endobronchial intubation. Drainage catheter insertion was successfully performed using the Seldinger technique, which is not a standard treatment of an infected aneurysmal sac. Improvement in the patient's clinical condition was observed at follow-ups, and CT showed total regression of the collection in the aneurysmal sac.

Numan, Furuzan, E-mail: drfgulsen@yahoo.com; Gulsen, Fatih; Cantasdemir, Murat; Solak, Serdar [Istanbul University, Department of Interventional Radiology, Cerrahpasa Faculty of Medicine (Turkey); Arbatli, Harun [Maltepe University, Department of Cardiovascular Surgery, Faculty of Medicine (Turkey)

2012-06-15

342

Giant lipoblastoma of the thigh: a rare soft tissue tumor in an infant.  

PubMed

Lipoblastoma is a rare lipomatous tumor encountered almost exclusively in infants and young children. It arises from embryonic white fat. The common site of involvement is the extremities. In spite of their potential for local invasion, they are benign tumors. We report a case of a lipoblastoma in an infant and review the literature pertaining to clinical management of these tumors. PMID:22531541

Akhtar, Tanveer; Alladi, Anand; Ahmed, Siddiq M; Siddappa, Odda S

2012-01-01

343

Tumor of mesonephric origin in a diverticulum of the urethra. An ultrastructural study.  

PubMed

A case of a rare tumor arising in a diverticulum of the urethra was studied. Light microscopy revealed the typical structures of mesonephric tumor with obvious infiltration of the muscularis. Electron microscopic appearance indicated that the tumor cells were immature and not totally characteristic of any tissue of origin. Apart from appearances suggesting rapid growth, cellular inclusions of various appearance were found. PMID:6818762

Schnoy, N; Leistenschneider, W

1982-01-01

344

Support to Aviation Control Service (SACS): an online service for near real-time satellite monitoring of volcanic plumes  

NASA Astrophysics Data System (ADS)

Volcanic eruptions emit plumes of ash and gases in the atmosphere, potentially at very high altitudes. Ash rich plumes are hazardous for airplanes as ash is very abrasive and easily melts inside their engines. With more than 50 active volcanoes per year and the ever increasing number of commercial flights, the safety of airplanes is a real concern. Satellite measurements are ideal for monitoring global volcanic activity and, in combination with atmospheric dispersion models, to track and forecast volcanic plumes. Here we present the Support to Aviation Control Service (SACS, sacs.aeronomie.be" target ="_blank"> http://sacs.aeronomie.be), which is a free online service initiated by ESA for the near real-time (NRT) satellite monitoring of volcanic plumes of SO2 and ash. It combines data from two UV-visible (OMI, GOME-2) and two infrared (AIRS, IASI) spectrometers. This new multi-sensor warning system of volcanic plumes, running since April 2012, is based on the detection of SO2 and is optimised to avoid false alerts while at the same time limiting the number of notifications in case of large plumes. The system shows successful results with 95% of our notifications corresponding to true volcanic activity.

Brenot, H.; Theys, N.; Clarisse, L.; van Geffen, J.; van Gent, J.; Van Roozendael, M.; van der A, R.; Hurtmans, D.; Coheur, P.-F.; Clerbaux, C.; Valks, P.; Hedelt, P.; Prata, F.; Rasson, O.; Sievers, K.; Zehner, C.

2013-10-01

345

Glomus Tumors and Neurofibromatosis: A Newly Recognized Association  

PubMed Central

Background: Glomus tumors are painful benign tumors arising from the neuromyoarterial elements of the glomus body, typically in a subungual location. Historically, glomus tumors have been considered isolated or sporadic, not typically associated with other disease processes. Over the last few years, however, multiple case reports, a molecular genetics study, and an epidemiologic study have confirmed an association between type I neurofibromatosis and glomus tumors. The purpose of this review is to summarize the existing information about the association between neurofibromatosis and glomus tumors and to determine whether glomus tumors that are associated with neurofibromatosis differ from isolated glomus tumors in terms of tumor number, location, and sex distribution. Methods: A PubMed, Ovid Medline, and Cochrane Database search was performed using the terms “glomus tumor,” “glomus tumour,” and “glomangioma” each combined with the search term “neurofibromatosis.” Fifteen English language articles were included. Information about the molecular genetics, patient sex, number of tumors per patient, and tumor location were recorded. Results: A total of 36 patients with glomus tumors and neurofibromatosis have been reported in the literature. Seventy-nine percent were female. Tumors were multifocal in 32% of patients, with an average of 1.4 glomus tumors per patient. Glomus tumors arose in a nonsubungual location in 38% of patients. Conclusions: A strong association between type I neurofibromatosis and glomus tumors has been identified. In neurofibromatosis patients with glomus tumors, the sex distribution, tumor location, and tumor burden appear similar to those in patients with isolated glomus tumors. Treating providers should be aware of this association to facilitate prompt diagnosis and treatment. PMID:25426397

Harrison, Bridget

2014-01-01

346

What Is Wilms Tumor?  

MedlinePLUS

... are living normal, healthy lives with just one kidney. Wilms tumors Wilms tumors are the most common cancers in ... rare cases children may develop other types of kidney tumors. Mesoblastic nephroma These tumors usually appear in the ...

347

Brain Tumor Diagnosis  

MedlinePLUS

... Types of Brain Scans X-rays Laboratory Tests DNA Profiling Biopsy Procedure Malignant and Benign Brain Tumors Tumor ... Types of Brain Scans X-rays Laboratory Tests DNA Profiling Biopsy Procedure Malignant and Benign Brain Tumors Tumor ...

348

Laparoscopic treatment of complete obliteration of the cul-de-sac associated with endometriosis: long-term follow-up of en bloc resection  

Microsoft Academic Search

Objective: To evaluate symptom relief following a laparoscopic technique designed for treatment of complete obliteration of the cul-de-sac associated with endometriosis, with fertility preserved.Design: Preoperative and postoperative questionnaire study of a cohort of patients with complete obliteration of the cul-de-sac undergoing a standardized laparoscopic surgical treatment.Setting: American tertiary referral center for the surgical treatment of endometriosis.Patients: Eighty-four consecutive patients undergoing

David B. Redwine; Jeremy T. Wright

2001-01-01

349

Japanese medaka exposed to gold nanoparticles: Only embryonic exposure generates irreversible hatching failure, developmental failure, and mortality of sac-fry.  

PubMed

This study evaluated irreversible toxicity effects of gold nanoparticles (AuNPs) during the short-term (only embryonic stage) and long-term (both embryo and sac-fry stages) exposures of Japanese ricefish, Oryzias latipes (medaka) embryos and sac-fry. Embryos and sac-fry exposed to AuNPs at 8 and 15days post-fertilization exhibited mortality, developmental failure, and abnormal appearance, and sac-fry additionally exhibited hatching failure and abnormal behavior. Embryos damaged by AuNPs during the embryonic stages failed to hatch and died, despite being raised under AuNP-free conditions after embryonic exposure. This study demonstrates that AuNPs have irreversible effects on O. latipes embryos and sac-fry, including the embryonic stages, regardless of the length of exposure. This result may be critical for predicting the potential continuous effects of AuNPs when the exposure duration of fish is short but includes the embryonic stages. To the best of our knowledge, this is the first study to test the toxicity of AuNP exposure on the embryos and sac-fry of O. latipes. PMID:24440878

Shin, Yu-Jin; Nam, Sun-Hwa; An, Youn-Joo

2014-04-01

350

Retrorectal tumors  

Microsoft Academic Search

One hundred twenty patients with primary retrorectal tumors (79 congenital, 14 neurogenic, 13 osseous, and 14 miscellaneous)\\u000a had their initial treatment at the Mayo Clinic from 1960 to 1979. The mean age was 43 years (100 patients were adults). Female\\u000a predominance was associated with congenital cysts (15?1) and male predominance with chordomas (5?1). Forty-three percent of\\u000a the patients had malignant

Shu-Wen Jao; Robert W. Beart; Robert J. Spencer; Herbert M. Reiman; Duane M. Ilstrup

1985-01-01

351

Two Case Reports of a Malignant Germ Cell Tumor of Ovary and a Granulosa Cell Tumor: Interest of Tumoral Immunochemistry in the Identification and Management  

PubMed Central

Objective: In this article, we present two case reports. The first case was a malignant germ cell tumor of the right ovary in a 23-year old woman and the second case was a bilateral undifferentiated granulosa cell tumor in a 71-year old woman. The aim of these reports is to illustrate the interest of the immunohistochemical analysis to define the correct diagnosis, to better classify these ovarian tumors and improve their management. Methods: In this study, we report two cases. The first case concerns a 23-year old woman (A) with a mixed germ cell tumor of the right ovary [dysgerminoma (75%), yolk sac tumor (20%), and a mature teratoma (5%)], and the second case concerns a 71-year old woman (B) with a bilateral non-differentiated and necrotic granulosa cell tumor of both ovaries. The staging system was used according to both the classifications: International Federation of Gynaecology and Obstetrics 1987 for ovarian cancer and TNM code 2009. Results: The immunostaining establishes the malignancy and the immunochemistry contributes to confirm effectively the right diagnosis (Tables 2 and 3). Conclusion: An immunohistochemical analysis is mandatory for the choice of chemotherapy to obtain a better response of the disease and improve the survival prognosis. The efficiency of the chemotherapy authorizes a conservative surgery including a unilateral salpingo-oophorectomy preserving fertility (A). Concerning the non-dysgerminoma tumor (B), and after a surgical staging and debulking, chemotherapy was recommended. The type of tumor and its histological feature conditioned the choice of treatment. The benefit of the immunohistological analysis in this case allowed the right adjuvant treatment. PMID:24982844

Bouquet de Jolinière, J.; Ben Ali, N.; Fadhlaoui, A.; Dubuisson, J. B.; Guillou, L.; Sutter, A.; Betticher, D.; Hoogewoud, H. M.; Feki, A.

2014-01-01

352

Presacral ganglioneuroma arising in an elderly man with persistent constipation  

Microsoft Academic Search

Presacral ganglioneuroma in a 70-year-old man with persistent constipation and its features on computed tomography, magnetic resonance, and endoscopic ultrasonography are presented. Barium enema study and laparotomy showed that constipation was caused mainly by extrinsic compression from this tumor. Computed tomography, magnetic resonance, endoscopic ultrasonographic features such as well-defined solid tumor with a cystic component and punctate calcifications may facilitate

T. Okai; T. Minamoto; K. Ohtsubo; Y. Takahashi; H. Kitagata; M. Kadoya; Y. Oda; N. Sawabu

2001-01-01

353

Epithelial–myoepithelial carcinoma arising in the nasal cavity  

Microsoft Academic Search

This study documents a case of an epithelial–myoepithelial carcinoma (EMC) in the left nasal cavity. A 70-year-old woman who presented with recurrent epistaxis of the left nasal nostril of 3 months duration was found to have a polypoid tumor in the left nasal cavity. A computed tomography (CT) scan revealed a tumor to occupy the left inferior and middle nasal

Koji Yamanegi; Nobuhiro Uwa; Mitsuyoshi Hirokawa; Hideki Ohyama; Masaki Hata; Naoko Yamada; Koichi Ogino; Kunichika Toh; Tomonori Terada; Akio Tanaka; Masafumi Sakagami; Nobuyuki Terada; Keiji Nakasho

2008-01-01

354

Giant Pindborg Tumor (Calcifying Epithelial Odontogenic Tumor): An Unusual Case Report with Radiologic-Pathologic Correlation  

PubMed Central

Odontogenic tumors develop in the jaws from odontogenic tissues such as enamel organ, Hertwig epithelial root sheath, dental lamina, and so on. A variety of tumors unique to the maxilla and mandible are therefore seen. Calcifying epithelial odontogenic tumor (CEOT) is a rare, aggressive, benign odontogenic tumor of epithelial origin accounting for only about 1% of all odontogenic tumors. It is eponymously called “Pindborg tumor”, as it was first described by Pindborg in 1955. The origin of this locally invasive tumor remains unknown. It is thought to arise from stratum intermedium. It commonly affects the posterior mandible manifesting as a slow-growing asymptomatic swelling often associated with an impacted tooth. We report a case of CEOT, for which, owing to its huge size we have proposed the term “giant” Pindborg tumor (CEOT). This is probably the largest case of this tumor reported so far in the English literature. The present case also has the classic yet rare “driven snow” appearance of the tumor on radiographs. PMID:24516774

Misra, Satya Ranjan; Lenka, Sthitaprajna; Sahoo, Sujit Ranjan; Mishra, Sobhan

2013-01-01

355

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis.  

PubMed

Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells. This could be due to short half-life of hematopoietic stem cells in culture or, alternatively, human embryonic stem cell-initiated hematopoiesis may be hematopoietic stem cell-independent, similar to yolk sac hematopoiesis, generating multipotent progenitors with limited expansion capacity. Since a MYB was reported to be an excellent marker for hematopoietic stem cell-dependent hematopoiesis, we generated a MYB-eGFP reporter human embryonic stem cell line to study formation of hematopoietic progenitor cells in vitro. We found CD34(+) hemogenic endothelial cells rounding up and developing into CD43(+) hematopoietic cells without expression of MYB-eGFP. MYB-eGFP(+) cells appeared relatively late in embryoid body cultures as CD34(+)CD43(+)CD45(-/lo) cells. These MYB-eGFP(+) cells were CD33 positive, proliferated in IL-3 containing media and hematopoietic differentiation was restricted to the granulocytic lineage. In agreement with data obtained on murine Myb(-/-) embryonic stem cells, bright eGFP expression was observed in a subpopulation of cells, during directed myeloid differentiation, which again belonged to the granulocytic lineage. In contrast, CD14(+) macrophage cells were consistently eGFP(-) and were derived from eGFP-precursors only. In summary, no evidence was obtained for in vitro generation of MYB(+) hematopoietic stem cells during embryoid body cultures. The observed MYB expression appeared late in culture and was confined to the granulocytic lineage. PMID:25381126

Vanhee, Stijn; De Mulder, Katrien; Van Caeneghem, Yasmine; Verstichel, Greet; Van Roy, Nadine; Menten, Björn; Velghe, Imke; Philippé, Jan; De Bleser, Dominique; Lambrecht, Bart N; Taghon, Tom; Leclercq, Georges; Kerre, Tessa; Vandekerckhove, Bart

2015-02-01

356

Enhanced solubility and intestinal absorption of candesartan cilexetil solid dispersions using everted rat intestinal sacs  

PubMed Central

Objective Candesartan cilexetil (CAN) is a poor aqueous soluble compound and a P-glycoprotein (P-gp) efflux pump substrate. These key factors are responsible for its incomplete intestinal absorption. Methods In this study, we investigated to enhance the absorption of CAN by improving its solubility and inhibiting intestinal P-gp activity. A phase solubility method was used to evaluate the aqueous solubility of CAN in PVP K30 (0.2–2%). Gibbs free energy (?Gtro) values were all negative. Solubility was enhanced by the freeze drying technique. The in vitro dissolution was evaluated using the USP paddle method. The interaction between drug and carrier was evaluated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Differential scanning calorimetry (DSC) studies. Naringin was selected as P-gp inhibitor. Absorption studies were performed using the everted gut sac model from rat jejunum. The drug analysis was performed by HPLC. Results FTIR spectra revealed no interaction between drug and PVP K30. From XRD and DSC data, CAN was in the amorphous form, which explains the cumulative release of drug from its prepared systems. We noticed an enhancement of CAN absorption by improving its solubility and inhibiting the P-gp activity. The significant results (p < 0.05) were obtained for freeze dried solid dispersions in the presence of P-gp inhibitor than without naringin (15 mg/kg) with an absorption enhancement of 8-fold. Conclusion Naringin, a natural flavonoid, has no undesirable side effects. Therefore, it could be employed as an excipient in the form of solid dispersions to increase CAN intestinal absorption and its oral bioavailability. PMID:25067902

Gurunath, S.; Nanjwade, Baswaraj K.; Patila, P.A.

2013-01-01

357

Experimental investigation of unsteady flow behaviour within a sac-type ventricular assist device (VAD).  

PubMed

The flow behaviour of human blood in a pneumatically driven sac-type ventricular assist device (VAD) has been simulated by a non-Newtonian polymer (Separan) solution, and investigated by both a one-component laser Doppler anemometer (LDA) in back-scattering mode and flow visualisation. The device was driven by a pneumatic driver with a squarewave output pressure, and was operated at a pumping rate of 70 bpm, and a systolic duration of 35% of the pumping cycle. The preload and the average afterload to the device were set at 10 mmHg and 100 mmHg, respectively. The output flowrate was 4.05 l min-1. The wall of the peripheral and the central parts of the blood chamber of the VAD were well 'washed' by a main vortex developed during filling and the flow components perpendicular to the base of the VAD produced by the diaphragm motions, respectively. Flow recirculation regions were found at several locations. Around the junction between the tube sections and the blood chamber, the recirculation with an associated fluid particle deposition indicates an underlying risk of thrombus formation. This risk will be reduced by modifying the device design. The maximum turbulent shear stress estimated from the maximum turbulent normal stress (74 N m-2), is unlikely to cause significant damage to blood for the exposure times found. The maximum particle residence time was found to be closely related to the heart rate and the degree of completion of ejection/filling. At a given flow rate, the operating conditions which produce the highest stroke volume give the shortest residence times. PMID:8514814

Jin, W; Clark, C

1993-06-01

358

Is oxidative stress the mechanism of blue sac disease in retene-exposed trout larvae?  

PubMed

Retene (7-isopropyl-1-methylphenanthrene) causes blue sac disease (BSD) in early life stages of fish, an effect similar to that of 2,3,7,8-tetrachlorodibenzo(p)dioxin. The signs of BSD include cytochrome P450 (CYP1A) induction, edema, hemorrhaging, and craniofacial deformities, indicating membrane damage, circulatory failure, and impaired development. To test if the underlying cause was oxidative stress, rainbow trout (Oncorhynchus mykiss) larvae were exposed to waterborne retene or to known prooxidants (paraquat, t-butyl hydroperoxide, and carbon tetrachloride) in the presence or absence of vitamin E, an antioxidant. Fish exposed to retene showed an increased prevalence of BSD, reduced tissue concentrations of vitamin E and total glutathione, and a lower percentage of glutathione in a reduced form. Coexposure to vitamin E reduced the prevalence of BSD and restored tissue concentrations of vitamin E, but it did not affect retene uptake or tissue concentrations of glutathione. These responses are consistent with oxidative stress as a mode of action of retene. However, retene did not affect whole-body lipid peroxide concentrations, and prooxidants did not affect the prevalence of BSD and had only minimal effects on tissue glutathione and vitamin E. Possible explanations for these conflicting results include prooxidant exposures were insufficient to generate oxidative stress; lipid peroxidation may not be measurable in whole-body homogenates of retene-exposed fish if effects are localized to endothelial cells, where CYP1A enzymes are most induced; or retene may have an alternate mode of action (e.g., adduction of retene metabolites to lipids, protein, or DNA). PMID:15779771

Bauder, Matthew B; Palace, Vincent P; Hodson, Peter V

2005-03-01

359

Thyroid type papillary carcinoma arising in a mature teratoma.  

PubMed

Struma ovary is a monodermal ovarian teratoma which contains mature thyroid tissue. We present an unusual case of papillary carcinoma arising in struma ovarii. A 52 year old post menopausal lady presented with a large right adnexal mass preoperatively diagnosed as a dermoid cyst. She underwent staging laparotomy and the histopatholgy report showed follicular variant of papillary carcinoma thyroid arising in a mature teratoma. She subsequently underwent total thyroidectomy to enable follow up with serum thyroglobulin and iodine scan. On follow up there is no evidence of disease recurrence. PMID:25419058

Kumar, Sreekanth S; Rema, P; R, Anila K; Varghese, Bipin T

2014-09-01

360

Endoscopic resection of subepithelial tumors  

PubMed Central

Management of subepithelial tumors (SETs) remains challenging. Endoscopic ultrasound (EUS) has improved differential diagnosis of these tumors but a definitive diagnosis on EUS findings alone can be achieved in the minority of cases. Complete endoscopic resection may provide a reasonable approach for tissue acquisition and may also be therapeutic in case of malignant lesions. Small SET restricted to the submucosa can be removed with established basic resection techniques. However, resection of SET arising from deeper layers of the gastrointestinal wall requires advanced endoscopic methods and harbours the risk of perforation. Innovative techniques such as submucosal tunneling and full thickness resection have expanded the frontiers of endoscopic therapy in the past years. This review will give an overview about endoscopic resection techniques of SET with a focus on novel methods. PMID:25512768

Schmidt, Arthur; Bauder, Markus; Riecken, Bettina; Caca, Karel

2014-01-01

361

Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia  

ClinicalTrials.gov

Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Childhood Choroid Plexus Tumor; Childhood Craniopharyngioma; Childhood Ependymoblastoma; Childhood Grade I Meningioma; Childhood Grade II Meningioma; Childhood Grade III Meningioma; Childhood Infratentorial Ependymoma; Childhood Medulloepithelioma; Childhood Mixed Glioma; Childhood Oligodendroglioma; Childhood Supratentorial Ependymoma; Gonadotroph Adenoma; Pituitary Basophilic Adenoma; Pituitary Chromophobe Adenoma; Pituitary Eosinophilic Adenoma; Prolactin Secreting Adenoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Childhood Spinal Cord Neoplasm; Recurrent Childhood Subependymal Giant Cell Astrocytoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Childhood Visual Pathway and Hypothalamic Glioma; Recurrent Childhood Visual Pathway Glioma; Recurrent Pituitary Tumor; Recurrent/Refractory Childhood Hodgkin Lymphoma; T-cell Childhood Acute Lymphoblastic Leukemia; T-cell Large Granular Lymphocyte Leukemia; TSH Secreting Adenoma; Unspecified Childhood Solid Tumor, Protocol Specific

2014-11-04

362

ADRENOCORTICAL TUMORS  

PubMed Central

Hormonally active tumors of the adrenal cortex are either benign adenomas or adenocarcinomas. They may be located within the adrenal gland or as adrenal rests along the Wolffian tract. Hyperplastic cortical tissue without actual neoplastic formation is also capable of elaborating excessive cortical secretions. At the present state of knowledge, any one or a combination of the following compounds may be elaborated in a given case: the electrolytic, glucogenic, androgenic, or estrogenic corticosteroids. Whether or not Cushing's syndrome is primarily pituitary or adrenal in origin is still a matter of conjecture. PMID:15426994

Shelton, E. Kost

1950-01-01

363

Well-Differentiated Extraskeletal Osteosarcoma Arising from the Retroperitoneum That Recurred as Anaplastic Spindle Cell Sarcoma  

PubMed Central

Extraskeletal osteosarcoma is an uncommon high-grade malignant soft tissue sarcoma. Well-differentiated extraskeletal osteosarcoma is thought to have a better prognosis than classical extraskeletal osteosarcoma, but dedifferentiation after recurrence has also been reported. We present a case of a primary retroperitoneal extraskeletal osteosarcoma in a 62-year-old Japanese woman. Abdominal CT revealed a large mass with diffuse calcification in the right retroperitoneal space and tumor resection was performed. The histopathological diagnosis was well-differentiated retroperitoneal extraskeletal osteosarcoma. She was followed up by CT every 6 months without adjuvant radiotherapy and chemotherapy for 31 months until anaplastic high-grade spindle cell sarcoma recurred in the retroperitoneum. Our case is the seventh reported description of well-differentiated extraskeletal sarcoma, and the first to arise in the retroperitoneum and recur as an entirely dedifferentiated spindle cell sarcoma. PMID:20224645

Arai, Hiromasa; Rino, Yasushi; Nishii, Teppei; Yukawa, Norio; Wada, Nobuyuki; Oshiro, Hisashi; Ishida, Tsuyoshi; Nakaigawa, Noboru; Masuda, Munetaka

2010-01-01

364

Familial Testicular Germ Cell Tumors  

PubMed Central

In this review, we define familial testicular germ cell tumors (FTGCT) as testicular germ cell tumors (TGCT) diagnosed in at least two blood relatives, a situation which occurs in 1-2% of all cases of TGCT. Brothers and fathers of TGCT patients have an 8-10 and 4-6 fold increased risk of TGCT, respectively, and an even higher elevated risk of TGCT in twin brothers of men with TGCT has been observed, suggesting that genetic elements play an important role in these tumors. Nevertheless, previous linkage studies with multiple FTGCT families did not uncover any high-penetrance genes and it has been concluded that the combined effects of multiple common alleles, each conferring modest risk, might underlie FTGCT. In agreement with this assumption, recent candidate gene association analyses have identified the chromosome Y gr/gr deletion and mutations in the PDE11A gene as genetic modifiers of FTGCT risk. Moreover, two genomewide association studies of predominantly sporadic but also familial cases of TGCT have identified three additional susceptibility loci, KITLG, SPRY4 and BAK1. Notably, all five loci are involved in the biology of primordial germ cells, representing the cell of origin of TGCT, suggesting that the tumors arise as a result of disturbed testicular development. PMID:20833340

Kratz, Christian P.; Mai, Phuong L.; Greene, Mark H.

2010-01-01

365

Tumors of the Infratemporal Fossa  

PubMed Central

Neoplastic processes involving the infratemporal fossa may originate from the tissues in the region, but more often are the result of extension from neighboring structures. Metastatic lesions located in the region are rarely encountered. Because of its concealed localization, tumors may remain unnoticed for some time. Clinical signs and symptoms often arise late, are insidious, and may be mistakenly attributed to other structures. The close proximity of the area to the intracranial structures, the orbit, the paranasal sinuses, the nasopharynx, and the facial area demands careful planning of surgical excision and combined procedures may be called for. Modern imaging techniques have made three-dimensional visualization of the extent of the pathology possible. Treatment depends on the histopathology and staging of the tumor. Several surgical approaches have been developed over the years. Radical tumor excision with preservation of the quality of life remain the ultimate goal for those tumors where surgery is indicated. Experience over a decade with various pathologies is presented. ImagesFigure 1p6-bFigure 2Figure 3 PMID:17171095

Tiwari, Rammohan; Quak, Jasper; Egeler, Saskia; Smeele, Ludi; Waal, Isaac v.d.; Valk, Paul v.d.; Leemans, Rene

2000-01-01

366

[Case of primary renal carcinoid tumor with hemorrhage].  

PubMed

Carcinoid tumors are low-grade malignant tumors that arise from neuroendocrine cells. Primary renal carcinoid tumors are extremely uncommon. A 63-year-old woman presented with a right abdominal mass and fever. Abdominal computed tomography demonstrated a mass in the right kidney; the mass measured 120 mm in diameter and showed hemorrhage. The patient underwent an uneventful right radical nephrectomy, and histological appearance was typical of carcinoid tumor. Immunohistochemistry demonstrated strong cytoplasmic labeling for neuron-specific enolase and synaptophysin. Additional examinations of the gastrointestinal tract did not show any evidence of carcinoid tumors. The patient remains free from disease recurrence at 8 months after the operation. The prognosis for primary renal carcinoid tumor is relatively optimistic. Complete surgical excision is the only recommended treatment for localized renal carcinoid tumor. PMID:20448447

Kubota, Yasuaki; Seike, Kensaku; Maeda, Shinichi; Tashiro, Kazuhiro

2010-04-01

367

Mucinous adenocarcinoma of the intestinal type arising from mature cystic teratoma of the ovary: a rare case report and review of the literature  

PubMed Central

Background Mature cystic teratomas (MCTs) are the most common germ cell tumors of the ovary. Malignant tranformation occurs in 1-2% of these neoplasms. Although most of the malignancies arising from MCTs are squamous cell carcinomas, adenocarcinoma of the gastrointestinal type is extremery rare. We herein present a case of adenocarcinoma of the intestinal type arising from a MCT. Case A 49-year-old female underwent surgery for a left ovarian tumor. The histology of the cyst walls revealed a MCT with a few hair shafts and a squamous layer, while another part of the tumor showed adenocarcinoma of the intestinal type. Five years after surgery, she is alive without disease. PMID:23216975

2012-01-01

368

BIODIVERSITY (COMMUNICATIONS ARISING): MAIZE TRANSGENE RESULTS IN MEXICO ARE ARTEFACTS  

Technology Transfer Automated Retrieval System (TEKTRAN)

Quist and Chapela's conclusion that the transgenes they claim to have detected in native maize in Oaxaca, Mexico, are predominantly reassorted and inserted into a "diversity of genomic contexts" seems to be based on an artefact arising from the inverse polymerase chain reaction (i-PCR) they used to ...

369

Transcultural Knowledge and Skills Transfer: Issues Arising from Evaluation Processes  

ERIC Educational Resources Information Center

The transfer of knowledge, policy and practice between nations increasingly involves knowledge of the theory and practice of evaluation. This article examines issues arising from the transcultural evaluation of a drug and alcohol misuse knowledge and skills transfer programme for nurses, nurse teachers and medical staff in the narcology service in…

Green, Anita J.; Holloway, David G.

2007-01-01

370

Shadow movies not arising from knots Daniel Denton  

E-print Network

Shadow movies not arising from knots Daniel Denton Peter Doyle Version 1.0 dated 17 June 2011 Abstract A shadow diagram is a knot diagram with under-over information omitted; a shadow movie is a sequence of shadow diagrams related by shadow Reidemeister moves. We show that not every shadow movie

Doyle, Peter

371

Constraints on food chain length arising from regional metacommunity dynamics  

E-print Network

Constraints on food chain length arising from regional metacommunity dynamics Vincent Calcagno1-en-Provence cedex 5, France Classical ecological theory has proposed several determinants of food chain length­prey metacommunities with extinction­colonization dynamics, we identify two distinct constraints on food chain length

Mouquet, Nicolas

372

ARISE: A Challenging 25-m Space Antenna Design  

NASA Technical Reports Server (NTRS)

ARISE (Advanced Radio Interferometry between Space and Earth). Future scientific and communications missions are conceptualizing using very large reflector antennas in space. The antenna dimensions are targeted from lOm to 25m beyond. Frequencies coveting L-band through W-band are being considered. these challenging missions, one may refer to ARISE (Advanced Radio Interferometry between Space and Earth), which is projected to utilize a 25-m dual Gregorian optics operating from 8 GHz to 86 Gl-lz . An artist's renditions Gregorian antenna concept is shown . The objective of this mission is to create a space-based VLBI system (integrated with ground based antennas) for high resolution mapping of black holes. Successful realization of ARISE necessitates development of several technologies . The most crucial technology is that of the deployable 25-m reflector that must work at frequencies as high as 43 and 86 GHz. The current baseline selection for ARISE is an inflatable antenna, under development for several other applications in communications and remote sensing.

Rahmat-Samii, Yahya; Hoferer, Robert A.

1999-01-01

373

Hepatocellular Carcinoma Arising in Non-Cirrhotic Haemochromatosis  

PubMed Central

Hepatocellular carcinoma arising in a patient with genetic haemachromatosis, without cirrhosis, has only been described once previously. We present a patient with a 15 year history of genetic haemachromatosis who underwent resection of a hepatocellular carcinoma in a liver with normal architecture. PMID:7547618

Thompson, N. P.; Stansby, G.; Jarmulowicz, M.; Hobbs, K. E.; McIntyre, N.

1995-01-01

374

A Case of Angiomyolipoma Arising in the Tongue  

PubMed Central

A 61-year-old woman was referred to our hospital with a mass in the left proglossis. The lesion was excised with a provisional diagnosis of hemangioma. The mass was well-demarcated and easily dissected with an ultrasonic surgical aspirator. The histopathologic diagnosis was angiomyolipoma arising in the tongue. There were no signs of recurrence at followup at 18 months. PMID:22937390

Yura, Shinya; Terahata, Shintaro; Sugiguchi, Shun

2011-01-01

375

Squamous cell carcinoma arising in endometriosis of the ovary.  

PubMed Central

Squamous cell carcinoma arising in ovarian endometriosis is extremely rare, but a case is reported in a 62 year old woman. If such an ovarian tumour is discovered evidence of teratoma, Brenner tumour, or endometriosis should be sought. Extensive sampling is mandatory as the developing tumour often overgrows the foci of endometriosis, thus obliterating evidence of its origin. Images PMID:1752990

Naresh, K N; Ahuja, V K; Rao, C R; Mukherjee, G; Bhargava, M K

1991-01-01

376

Rosetted glioneuronal tumor: a case with proliferating neuronal nodules.  

PubMed

Glioneuronal tumors with neuropil-like islands (rosetted glioneuronal tumors) were recently reported as a novel brain tumor entity with characteristic clinicopathological features (Am J Surg Pathol 23: 502, 1999). Here we describe the clinical, histological and genetic features of another case arising in the parietal lobe of a 43-year-old man suffering from focal motor epilepsy. Histologically, nodules of small neuronal tumor cells immunoreactive for synaptophysin and NeuN were embedded within a diffuse astrocytoma. Remarkably, highest proliferative activity was observed within the neuronal nodules. Comparative genomic hybridization revealed a gain of chromosome 7q and a loss on chromosome 9p. PMID:11484825

Keyvani, K; Rickert, C H; von Wild, K; Paulus, W

2001-05-01

377

Evolutionary Theory Suggest New Mechanism for Genetic Heterogeneity of Tumors | Physical Sciences in Oncology  

Cancer.gov

One of the most consistent characteristics of solid tumors is the genetic heterogeneity of the cells that make up the tumor. Current dogma holds that this heterogeneity results from the effect of random mutations that develop as a result of the instability of cancer cell genes. However, a theoretical analysis of tumor evolution suggests that this heterogeneity arises from predictable variations in the local environments that form in tumors and the resulting adaptations that cells make those changing conditions.

378

Mammary analog secretory carcinoma of salivary gland with high-grade histology arising in hard palate, report of a case and review of literature  

PubMed Central

Mammary gland analog secretary carcinoma (MASC) of salivary gland is typically a tumor of low histologic grade and behaves as a low-grade malignancy with relatively benign course. This tumor shares histologic features, immunohistochemical profile, and a highly specific genetic translocation, ETV6-NTRK3, with secretory carcinoma of breast. Histologically, it is often mistaken as acinic cell carcinoma, adenocarcinoma not otherwise specified, and other primary salivary gland tumors. Here we report a case of MASC with high-grade transformation and cervical lymph node metastases confirmed with ETV6-NTRK3 translocation arising in the hard palate of a 41 year-old adult. Interestingly, the metastatic carcinoma has lower grade than the original tumor which strongly support malignant transformation of the original tumor. Most commonly, MASC arises from the parotid gland and less often in minor salivary glands. Metastasis is relatively uncommon and high-grade histology has only been reported in four cases with three of them arising from the parotid gland and the location of the fourth one has not been reported. This is the first case with high grade histology that arise from minor salivary gland and it emphasizes the importance of molecular screening of salivary gland tumor with high-grade histology for ETV6-NTRK3 translocation. In our literature of 115 cases that includes the current case, MASC occurred predominantly in adult with only a few cases under 18 years of age and a male to female ratio of 1.2:1. Parotid gland is more commonly affected but there is also significant occurrence in minor salivary glands. Except for the cases with high grade histology, the overall prognosis is good.

Luo, Wenyi; Lindley, Sarah W; Lindley, Peter H; Krempl, Gregory A; Seethala, Raja R; Fung, Kar-Ming

2014-01-01

379

Endovascular Repair of a Right-Sided Descending Thoracic Aortic Aneurysm Associated with a Right Aortic Arch and a Left Subclavian Artery Arising from a Kommerell's Diverticulum  

SciTech Connect

This case report describes the endovascular repair of a right-sided descending thoracic aortic aneurysm associated with a right aortic arch and an aberrant left subclavian artery. A 76-year-old male with multiple comorbidities was incidentally found to have a right-sided descending thoracic aortic aneurysm with a maximum diameter of 6.2 cm. Additionally, there was a right aortic arch with a retroesophageal segment and separate arch branches arising in the following order: left common carotid artery, right common carotid artery, right subclavian artery, and left subclavian artery that was aberrant, arising from a Kommerrell's diverticulum. The aneurysm was successfully excluded by deployment of a Zenith TX1 36 x 32 x 20-mm stent-graft using wire traction technique via the left femoral and right brachial arteries in order to deal with two severe aortic angulations. At 18-month follow-up the patient was doing well, with aneurysm sac shrinkage to 5.9 cm and no signs of endoleak or migration. Endovascular repair of right-sided descending thoracic aortic aneurysms with a right arch and aberrant left subclavian artery is feasible, safe, and effective. In such rare configurations, which demand considerably increased technical dexterity and center experience, endovascular repair emerges as an attractive therapeutic option.

Klonaris, Chris, E-mail: chris_klonaris@yahoo.com; Avgerinos, Efthimios D.; Katsargyris, Athanasios; Matthaiou, Alexandros; Georgopoulos, Sotirios; Psarros, Vasileios; Bastounis, Elias ['LAIKON' Hospital, Athens University Medical School, First Department of Surgery, Vascular Division (Greece)

2009-07-15

380

Calcified angioleiomyoma of foot arising from the posterior tibial artery  

Microsoft Academic Search

Case  A 77-year-old woman was presented with a mass in the plantar side of left foot. Physical examinations revealed 30?×?20-mm-sized\\u000a hard mass with tenderness. Plane X-ray and computed tomography showed heterogenously calcified tumor that contacted with posterior\\u000a tibial artery. Magnetic resonance imaging indicated spindle-shaped tumor in subcutis. That was isointense and hypointense\\u000a on the T1-weighted image and hyperintense on the T2-weighted

Masaru Kadowaki; Soichiro Yamamoto; Yuji Uchio

2010-01-01

381

Regulation of carotenoid accumulation and the expression of carotenoid metabolic genes in citrus juice sacs in vitro  

PubMed Central

In the present study, to investigate the mechanisms regulating carotenoid accumulation in citrus, a culture system was set up in vitro with juice sacs of three citrus varieties, Satsuma mandarin (Citrus unshiu Marc.), Valencia orange (Citrus sinensis Osbeck), and Lisbon lemon (Citrus limon Burm.f.). The juice sacs of all the three varieties enlarged gradually with carotenoid accumulation. The changing patterns of carotenoid content and the expression of carotenoid metabolic genes in juice sacs in vitro were similar to those ripening on trees in the three varieties. Using this system, the changes in the carotenoid content and the expression of carotenoid metabolic genes in response to environmental stimuli were investigated. The results showed that carotenoid accumulation was induced by blue light treatment, but was not affected by red light treatment in the three varieties. Different regulation of CitPSY expression, which was up-regulated by blue light while unaffected by red light, led to different changes in carotenoid content in response to these two treatments in Satsuma mandarin and Valencia orange. In all three varieties, increases in carotenoid content were observed with sucrose and mannitol treatments. However, the accumulation of carotenoid in the two treatments was regulated by distinct mechanisms at the transcriptional level. With abscisic acid (ABA) treatment, the expression of the genes investigated in this study was up-regulated in Satsuma mandarin and Lisbon lemon, indicating that ABA induced its own biosynthesis at the transcriptional level. This feedback regulation of ABA led to decreases in carotenoid content. With gibberellin (GA) treatment, carotenoid content was significantly decreased in the three varieties. Changes in the expression of genes related to carotenoid metabolism varied among the three varieties in response to GA treatment. These results provided insights into improving carotenoid content and composition in citrus during fruit maturation. PMID:21994171

Zhang, Lancui; Ma, Gang; Kato, Masaya; Yamawaki, Kazuki; Takagi, Toshihiko; Kiriiwa, Yoshikazu; Ikoma, Yoshinori; Matsumoto, Hikaru; Yoshioka, Terutaka; Nesumi, Hirohisa

2012-01-01

382

1?,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac.  

PubMed

Previous studies have shown that 1?,25-dihydroxyvitamin D3 (1,25(OH)2D3) treatment (2.56 nmol/kg i.p. daily×4) increased PepT1, Mrp2, Mrp4, Asbt, but not Mdr1/P-gp in the rat small intestine. In this study, the intestinal everted sac technique, together with various select probes: mannitol (paracellular transport), glycylsarcosine (PepT1), 5(and 6)-carboxy-2',7'-dichlorofluorescein (CDF) diacetate (precursor of CDF for Mrp2), adefovir dipivoxil (precursor of adefovir for Mrp4) and digoxin (P-gp) was used to examine the functional changes of these transporters. After establishing identical permeabilities (Papp) of mannitol for the apical-to-basolateral (A-to-B) and basolateral-to-apical (B-to-A) directions at 20?min in 1,25(OH)2D3-treated vs. vehicle-treated duodenal, jejunal and ileal everted sacs, a significant enhancement of net A-to-B transport of glycylsarcosine in the duodenum, increased B-to-A transport of CDF and A-to-B and B-to-A transport of adefovir in the jejunum were observed with 1,25(OH)2 D3 treatment. However, the A-to-B and B-to-A transport of digoxin in the ileum was unchanged. These changes in transporter function in the rat intestinal everted sac corresponded well to changes in proteins that were observed previously. This study confirms that the rat intestinal PepT1, Mrp2 and Mrp4, but not P-gp are functionally induced by 1,25(OH)2D3 treatment via the vitamin D receptor (VDR). PMID:21341280

Maeng, Han-Joo; Durk, Matthew R; Chow, Edwin C Y; Ghoneim, Ragia; Pang, K Sandy

2011-03-01

383

Deficiency of Zonula Occludens-1 Causes Embryonic Lethal Phenotype Associated with Defected Yolk Sac Angiogenesis and Apoptosis of Embryonic Cells  

PubMed Central

Zonula occludens (ZO)-1/2/3 are the members of the TJ-MAGUK family of membrane-associated guanylate kinases associated with tight junctions. To investigate the role of ZO-1 (encoded by Tjp1) in vivo, ZO-1 knockout (Tjp1?/?) mice were generated by gene targeting. Although heterozygous mice showed normal development and fertility, delayed growth and development were evident from E8.5 onward in Tjp1?/? embryos, and no viable Tjp1?/? embryos were observed beyond E11.5. Tjp1?/? embryos exhibited massive apoptosis in the notochord, neural tube area, and allantois at embryonic day (E)9.5. In the yolk sac, the ZO-1 deficiency induced defects in vascular development, with impaired formation of vascular trees, along with defective chorioallantoic fusion. Immunostaining of wild-type embryos at E8.5 for ZO-1/2/3 revealed that ZO-1/2 were expressed in almost all embryonic cells, showing tight junction-localizing patterns, with or without ZO-3, which was confined to the epithelial cells. ZO-1 deficiency depleted ZO-1-expression without influence on ZO-2/3 expression. In Tjp1+/+ yolk sac extraembryonic mesoderm, ZO-1 was dominant without ZO-2/3 expression. Thus, ZO-1 deficiency resulted in mesoderms with no ZO-1/2/3, associated with mislocalization of endothelial junctional adhesion molecules. As a result, angiogenesis was defected in Tjp1?/? yolk sac, although differentiation of endothelial cells seemed to be normal. In conclusion, ZO-1 may be functionally important for cell remodeling and tissue organization in both the embryonic and extraembryonic regions, thus playing an essential role in embryonic development. PMID:18353970

Katsuno, Tatsuya; Umeda, Kazuaki; Matsui, Takeshi; Hata, Masaki; Tamura, Atsushi; Itoh, Masahiko; Takeuchi, Kosei; Fujimori, Toshihiko; Nabeshima, Yo-ichi; Noda, Tetsuo; Tsukita, Shoichiro

2008-01-01

384

Evidence of the Most Stretchable Egg Sac Silk Stalk, of the European Spider of the Year Meta menardi  

PubMed Central

Spider silks display generally strong mechanical properties, even if differences between species and within the same species can be observed. While many different types of silks have been tested, the mechanical properties of stalks of silk taken from the egg sac of the cave spider Meta menardi have not yet been analyzed. Meta menardi has recently been chosen as the “European spider of the year 2012”, from the European Society of Arachnology. Here we report a study where silk stalks were collected directly from several caves in the north-west of Italy. Field emission scanning electron microscope (FESEM) images showed that stalks are made up of a large number of threads, each of them with diameter of 6.03±0.58 µm. The stalks were strained at the constant rate of 2 mm/min, using a tensile testing machine. The observed maximum stress, strain and toughness modulus, defined as the area under the stress-strain curve, are 0.64 GPa, 751% and 130.7 MJ/m3, respectively. To the best of our knowledge, such an observed huge elongation has never been reported for egg sac silk stalks and suggests a huge unrolling microscopic mechanism of the macroscopic stalk that, as a continuation of the protective egg sac, is expected to be composed by fibres very densely and randomly packed. The Weibull statistics was used to analyze the results from mechanical testing, and an average value of Weibull modulus (m) is deduced to be in the range of 1.5–1.8 with a Weibull scale parameter (?0) in the range of 0.33–0.41 GPa, showing a high coefficient of correlation (R2?=?0.97). PMID:22347380

Lepore, Emiliano; Marchioro, Andrea; Isaia, Marco; Buehler, Markus J.; Pugno, Nicola M.

2012-01-01

385

Development of the endolymphatic sac and duct in the Japanese red-bellied newt, Cynops pyrrhogaster  

NASA Technical Reports Server (NTRS)

The development and maturation of the endolymphatic sac (ES) and duct (ED) were studied in the newt Cynops pyrrhogaster. The ES first appears as an oval capsule at the dorsal-medial tip of the otic vesicle at stage 39, about 11 days after oviposition. The ES consists of polymorphous epithelial cells with a minimum of cytoplasm. The intercellular space (IS) between the epithelial cells is narrow and has a smooth surface. At stage 44, the size of the ES increases as many vacuoles in the IS become filled. At stage 46, 18 days after oviposition, the ES elongates markedly and a slit-like lumen is found in the ES. The epithelium contains a few cell organelles which are scattered in the cytoplasm. The vacuoles in the IS are fused, which expands the IS. Two days later (stage 48), floccular material (endolymph) is present in the expanded lumen. The IS dilates and has a wide and irregular appearance. At stage 50, approximately 26 days after oviposition, the ES extends and expands significantly and crystals (otoconia) can now be seen in the widened lumen of the ES. The cytoplasm of the cuboidal epithelial cells contains an abundance of vesicles surrounded by ribosomes and Golgi complexes. Intercellular digitations are formed in the expanded IS. At stage 54, the ES forms a large bellow-like pouch. Numerous otoconia accumulate in the lumen. Free floating cells and cell debris can be seen in the lumen at this stage. The epithelial cells contain numerous cytoplasmic organelles which are evenly distributed in the cytoplasm. Granules are found in the apical and lateral cytoplasm. The IS is loose and displays a labyrinthine appearance. The primitive ED first appears as a connection between the ES and the saccule but no lumen is present inside at stage 39. At stage 46, a narrow lumen is formed in the ED, which corresponds to the formation of the ES lumen. At stage 50, as the ED extends, floccular material is seen in the lumen. At stage 54, the ED bears numerous microvilli on its luminal surface. Otoconia and endolymph are present in the ED. Tight junctions between the epithelial cells are formed at stage 46. A fully developed intercellular junctional complex is produced at stage 54. Based on the development of the ES and ED, the maturation of function of the ES and ED are discussed.

Gao, W.; Wiederhold, M. L.; Harrison, J. L.

1998-01-01

386

Trichilemmoma arising in the nasal vestibule: report of three cases with special emphasis on the differential diagnosis.  

PubMed

Trichilemmoma is a benign cutaneous epithelial tumor with differentiation towards cells of the outer hair root sheath and usually presents as a small papule on the face of middle-aged or older adults. We herein report three cases of trichilemmoma located in the nasal vestibule, including two of the conventional type and one of the desmoplastic variant. To our knowledge, only one case of trichilemmoma arising in the nasal vestibule has been previously reported. Trichilemmoma must be included in the differential diagnosis of epithelial lesions arising in this location. This is particularly important in the case of the desmoplastic trichilemmoma, a tumor that resembles invasive carcinoma such as desmoplastic squamous cell carcinoma, sclerosing basal cell carcinoma, and trichilemmal carcinoma. The circumscription of the lesion, the architectural pattern of epithelial cell cords and small nests merging with a desmoplastic stroma in the central area of the tumor, the expression of CD34, and the lack of an obvious squamous differentiation or basaloid foci favor the diagnosis of desmoplastic trichilemmoma. All these features help to rule out the diagnosis of carcinoma with significant clinical implications. PMID:22669747

Herráiz, Marisa; Martín-Fragueiro, Luz M; Tardío, Juan C

2012-12-01

387

Mixed adeno(neuro)endocrine carcinoma arising from the ectopic gastric mucosa of the upper thoracic esophagus  

PubMed Central

We report a case of mixed adenoendocrine carcinoma of the upper thoracic esophagus arising from ectopic gastric mucosa. A 64-year-old man who had been diagnosed with an esophageal tumor on the basis of esophagoscopy was referred to our hospital. Upper gastrointestinal endoscopy revealed the presence of ectopic gastric mucosa and an adjacent pedunculated lesion located on the posterior wall of the upper thoracic esophagus. Subtotal esophagectomy with three-field lymph node dissection was performed. A microscopic examination revealed that there was a partially intermingling component of neuroendocrine carcinoma adjacent to a tubular adenocarcinoma which was conterminous with the area of the ectopic gastric mucosa. Although the tubular adenocarcinoma was confined to the mucosa and submucosa, the neuroendocrine carcinoma had invaded the submucosaand there was vascular permeation. Each component accounted for 30% or more of the tumor, so the final histopathological diagnosis was mixed adenoendocrine carcinoma of the upper thoracic esophagus arising from ectopic gastric mucosa. Adjuvant chemotherapy was not performed, because the postoperative tumor stage was IA. The patient was well and had no evidence of recurrence 16 months after surgery. PMID:24139488

2013-01-01

388

Benign sacral tumors.  

PubMed

Primary tumors of the sacrum are rare. In adults, the most common sacral tumors are metastases. The most common primary sacral tumor is a chordoma. Chordomas along as well as tumors such as chondrosarcomas, osteosarcomas, myxopapillary ependymomas, myelomas, and Ewing sarcomas are considered malignant. In this article the authors focus on benign sacral tumors. PMID:15350045

Deutsch, Harel; Mummaneni, Praveen V; Haid, Regis W; Rodts, Gerald E; Ondra, Stephen L

2003-08-15

389

Pharmacogenetics in neuroendocrine tumors of the pancreas.  

PubMed

Neuroendocrine tumors (NETs) arise from cells distributed throughout the endocrine system. Although, NETs are heterogeneous in their behavior, they tend to be more aggressive when arising in the pancreas. Pancreatic NET (panNET) represents three percent of all primary pancreatic neoplasms. Symptomatic and progressive panNETs are generally treated with cytotoxic chemotherapy, whereas molecular targeted therapy is used for nonfunctional tumors without aggressive features. Pharmacogenetics has increasingly been used recently to better identify potential targets for therapy and help select patient-specific therapy. In this review, we discuss two abstracts (Abstracts #4113 and #e15169) presented at the ASCO Annual Meeting in Chicago this year, outlining the potential role of tumor gene and gene product profiling in disease management. We describe what is known about the pathogenesis of these tumors, role of decreased gene product expression (MGMT, RRM1, MET) and its application in cytotoxic therapy selection, as well as genetic mutations that can be used for molecular targeted therapy. With an overall shift towards personalized medicine, it has become ever more important to identify the molecular signature of a tumor as it appears to dictate the clinical behavior and response to therapy. PMID:25076325

Rizvi, Syed Mujtaba; Wong, Joyce; Saif, Muhammad Wasif; Jia, Yuxia

2014-07-01

390

Basaloid ductal carcinoma in situ arising in salivary gland metaplasia of the breast: a case report  

PubMed Central

Salivary gland metaplasia is a newly recognized, adenosis-like lesion which could not be classified according to known categories of adenosis of the breast. We report a case of basaloid ductal carcinoma in situ (DCIS) arising in a background of salivary gland metaplasia in a 49-year old woman who visited our hospital for a right breast mass. Breast ultrasonography showed a multi-lobulating mixed hypoechoic and isoechoic mass measuring 2.9 cm in size at the periareolar area. Histologically, the lesion showed a well-defined DCIS with basaloid tumor cells and central comedo-type necrosis surrounded by salivary gland metaplasia composed of glands or ducts not specific to the breast, ducts with cribriform proliferation of luminal epithelial cells, and ducts with varying degrees of proliferation of basaloid cells including solid nests of basaloid cells. Salivary gland metaplasia is a most unusual lesion of the breast characterized by salivary gland-type acini and ducts with various proliferations of luminal and basaloid cells, and accompanied by malignant tumor of basal cell type. PMID:25337293

Jang, Eun Jeong; Kang, Su Hwan; Bae, Young Kyung

2014-01-01

391

Preoperative diagnosis of ductal carcinoma in situ arising within a mammary fibroadenoma: a case report.  

PubMed

Fibroadenoma is the most common form of benign breast tumor and the most common breast tumor in women under 30 years of age. However, carcinoma arising within a fibroadenoma is unusual, with over 100 cases reported in the literature. Histological diagnosis is typically unexpected. A 46-year-old female with no family history of breast malignancies was admitted for an elastic hard lump in the upper-outer quadrant of her right breast. At a clinic that she visited previously, her condition was diagnosed by core needle biopsy with four specimens showing fibroadenoma with borderline atypical ductal hyperplasia at pathology. Excisional biopsy was recommended for pathological diagnosis. The patient requested a definitive diagnosis and alternative treatment to tumorectomy. More biopsy specimens were needed for pathological diagnosis; therefore, ultrasonography-guided vacuum-assisted core needle biopsies were obtained, confirming ductal carcinoma in situ with questionable microinvasion of intracanalicular- and pericanalicular-type fibroadenoma. Right breast-conserving surgery and sentinel lymph node biopsy were immediately performed for radical therapy. We present this case to increase awareness of this entity and stress the need for histological evaluation of some breast masses. PMID:21693482

Ooe, Asako; Takahara, Sachiko; Sumiyoshi, Kazuhiro; Yamamoto, Hitoshi; Shiba, Eiichi; Kawai, Jun

2011-07-01

392

Tumors in the tracheobronchial tree: CT and FDG PET features.  

PubMed

A variety of tumors, including primary malignant tumors, secondary malignant tumors, and benign tumors, can occur in the tracheobronchial tree. Primary malignant tumors commonly originate from the surface epithelium or the salivary glands, whereas most benign tumors arise from the mesenchymal tissue. At computed tomography (CT), primary malignant tumors manifest as a polypoid lesion, a focal sessile lesion, eccentric narrowing of the airway lumen, or circumferential wall thickening. At fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET), most squamous cell carcinomas show high uptake, whereas adenoid cystic carcinoma and mucoepidermoid carcinoma show variable uptake depending on the grade of differentiation. High-grade malignancies tend to show high and homogeneous uptake. Carcinoid tumors commonly show intense enhancement at contrast material-enhanced CT, which can be helpful in making the diagnosis, and usually have lower uptake at FDG PET than would be expected for a malignant tumor. Secondary malignant tumors occur as a result of either hematogenous metastasis or direct invasion by a malignancy from an adjacent structure. Their CT manifestations are similar to those of primary malignant tumors, with uptake at FDG PET depending primarily on the metabolic activity and degree of differentiation of the primary tumor. Among the benign tumors, hamartoma and lipoma can show characteristic CT findings such as "popcorn" calcification or internal fat. However, CT findings in most benign tumors are nonspecific. At FDG PET, benign tumors usually show little or no uptake and can be differentiated from malignant tumors. Knowledge of the characteristic CT and FDG PET findings of tracheobronchial tumors can aid in diagnosis and treatment planning. PMID:19168836

Park, Chang Min; Goo, Jin Mo; Lee, Hyun Ju; Kim, Min A; Lee, Chang Hyun; Kang, Mi-Jin

2009-01-01

393

Ceramide kinase promotes tumor cell survival and mammary tumor recurrence.  

PubMed

Recurrent breast cancer is typically an incurable disease and, as such, is disproportionately responsible for deaths from this disease. Recurrent breast cancers arise from the pool of disseminated tumor cells (DTC) that survive adjuvant or neoadjuvant therapy, and patients with detectable DTCs following therapy are at substantially increased risk for recurrence. Consequently, the identification of pathways that contribute to the survival of breast cancer cells following therapy could aid in the development of more effective therapies that decrease the burden of residual disease and thereby reduce the risk of breast cancer recurrence. We now report that ceramide kinase (Cerk) is required for mammary tumor recurrence following HER2/neu pathway inhibition and is spontaneously upregulated during tumor recurrence in multiple genetically engineered mouse models for breast cancer. We find that Cerk is rapidly upregulated in tumor cells following HER2/neu downregulation or treatment with Adriamycin and that Cerk is required for tumor cell survival following HER2/neu downregulation. Consistent with our observations in mouse models, analysis of gene expression profiles from more than 2,200 patients revealed that elevated CERK expression is associated with an increased risk of recurrence in women with breast cancer. In addition, although CERK expression is associated with aggressive subtypes of breast cancer, including those that are estrogen receptor-negative, HER2(+), basal-like, or high grade, its association with poor clinical outcome is independent of these clinicopathologic variables. Together, our findings identify a functional role for Cerk in breast cancer recurrence and suggest the clinical utility of agents targeted against this prosurvival pathway. PMID:25164007

Payne, Ania W; Pant, Dhruv K; Pan, Tien-Chi; Chodosh, Lewis A

2014-11-01

394

Analysis of the vibratory excitation arising from spiral bevel gears  

NASA Technical Reports Server (NTRS)

Tools required to understand and predict in terms of its underlying causes the vibratory excitation arising from meshing spiral bevel gears are developed. A generalized three component transmission error of meshing spiral bevel gears is defined. Equations are derived that yield the three components of the generalized transmission error in terms of deviations of tooth running surfaces from equispaced perfect spherical involute surfaces and tooth/gearbody elastic deformations arising from the three components of the generalized force transmitted by the meshing gears. A method for incorporating these equations into the equations of motion of a gear system is described. Equations are derived for the three components of the generalized force transmitted by the gears which are valid whenever inertial effects of the meshing gears and their supports are negligible. Bearing offsets from the positions occupied by the shaft centerlines of perfect spherical involute bevel gears and bearing/bearing support flexibilities enter into the computation of these forces.

Mark, William D.

1987-01-01

395

Colonic adenocarcinoma arising from gastric heterotopia: a case study.  

PubMed

Heterotopic gastric mucosa occurs in all areas of the gastrointestinal tract including the nasopharynx, tongue, esophagus, small intestine, colon, and rectum. Gastric heterotopia of the large bowel is infrequent, and most cases have been reported in the rectum. Review of the literature has revealed only eight cases involving the colon proximal to the rectum. Little is known of the natural history of gastric heterotopias, except that. It usually presents with gastrointestinal bleeding, though other serious complications such as bowel perforation, intussusceptions, and fistula formation, are possible. Further, it is unclear whether heterotopic gastric mucosa progresses to malignancy. Herein, we describe a case of adenocarcinoma of the transverse colon arising from gastric heterotopia. To the best of our knowledge, this is the first report of adenocarcinoma arising from heterotopic gastric mucosa in the colon. PMID:23837024

Ko, Hyoungsuk; Park, Shin Young; Cha, Eun Jung; Sohn, Jang Sihn

2013-06-01

396

Membranous basal cell adenoma arising in the eyelid  

PubMed Central

Basal cell adenoma (BCA) is a specific entity that lacks the myxochondroid stromal component of pleomorphic adenoma. Membranous basal cell adenoma is a rare variant of BCA, which is characteristic by abundant eosinophilicextracellular hyaline material deposited either inside or at the periphery of the epithelial islands. Herin we describe the first case of membranous BCA arising in the upper eyelid in a 38-year-old woman. A well-demarcated nodule arising in the eyelid was composed of isomorphic basaloid cells organized with a prominent basal cell layer and distinct basement membrane-like material. Immunohistochemically, S100 protein and p63 highlighted the basal aspect of the peripheral epithelial cells, while CK7 expressed on the luminal cells. A diagnosis of membranous basal cell adenoma of the eyelid was made. At follow-up for 2 years and 3 months later, there was no evidence of recurrence. Further pathological characteristics of this disease are discussed. PMID:25120843

Huang, Yong; Yang, Min; Ding, Jianhui

2014-01-01

397

Changes in lung tumor shape during respiration  

NASA Astrophysics Data System (ADS)

Evidence that some lung tumors change shape during respiration is derived from respiratory gated CT data by statistical shape modeling and image manipulation. Some tumors behave as rigid objects while others show systematic shape changes. Two views of lung motion are presented to allow analysis of the results. In the first, lung motion is viewed as a wave motion in which inertial effects arising from mass are present and in the second it is a quasistatic motion in which the mass of the lung tissues is neglected. In the first scenario, the extremes of tumor compression and expansion are expected to correlate with maximum upward and downward velocity of the tumor, respectively. In the second, they should occur at end exhale and end inhale, respectively. An observed correlation between tumor strain and tumor velocity provides more support for the first view of lung motion and may explain why previous attempts at observing tumor shape changes during respiration have largely failed. The implications for the optimum gating of radiation therapy are discussed.

Kyriakou, E.; McKenzie, D. R.

2012-02-01

398

Scheduling Issues Arising from Automated Real-Time System Design  

Microsoft Academic Search

We have developed CIRCA, the Cooperative Intelligent Real-time Control Architecture, as amechanism for automating the on-line, adaptive design of real-time systems. The real-time controltasks generated by CIRCA do not meet many of the simplifying assumptions made to developtraditional scheduling algorithms. We examine several problematic issues that arise in schedulingthese automatically-generated real-time monitoring tasks, and describe two solution approaches.In the first

David J. Musliner

1995-01-01

399

High blood pressure arising from a defect in vascular function  

Microsoft Academic Search

Hypertension, a major cardiovascular risk factor and cause of mortality worldwide, is thought to arise from primary renal abnormalities. However, the etiology of most cases of hypertension remains unexplained. Vascular tone, an important determinant of blood pressure, is regulated by nitric oxide, which causes vascular relaxation by increasing intracellular cGMP and activating cGMP-dependent protein kinase I (PKGI). Here we show

Simon K. Michael; Howard K. Surks; Yuepeng Wang; Yan Zhu; Robert Blanton; Michelle Jamnongjit; Mark Aronovitz; Wendy Baur; Kenichi Ohtani; Michael K. Wilkerson; Adrian D. Bonev; Mark T. Nelson; Richard H. Karas; Michael E. Mendelsohn

2008-01-01

400

Ameloblastoma Arising from A Dentigerous Cyst-A Case Report  

PubMed Central

We are reporting a case of an ameloblastoma which arose in the wall of a dentigerous cyst. The clinical, radiographic and histological characteristics were similar to those of dentigerous cysts, as were seen on doing an incisional biopsy. Enucleation was done intraorally under local anaesthesia. Post-operative excisional biopsy revealed strands and cords arising from the cystic lining, which are suggestive of ameloblastic changes. PMID:24995259

Bhushan, NVV Satya; Navatha, M.; Kumar, B. Kiran

2014-01-01

401

Moire effects arising on mechanical treatment of single crystal surface  

NASA Astrophysics Data System (ADS)

X-ray diffraction moiré methods in the geometry of L-L-L Laue diffraction have been used to determine crystal structure defects arising in the near-surface Si layers on mechanical treatment (cutting with diamond disc and grinding). A model of damaged layer has been proposed and zone dimensions have been determined, namely polycrystalline structure, microcracks, dislocation assemblies and packing defects, crystal elastic strain.

Raransky, Mykola; Balazyuk, Vitaliy; Melnyk, Mykola; Kniginitska, Olga; Gunko, Mykhailo

2013-12-01

402

Acinic cell carcinoma of the breast arising in microglandular adenosis.  

PubMed

Acinic cell carcinoma is a rare breast tumour belonging to salivary gland-like tumours of the breast. They are "triple-negative" breast cancers even if their biological behaviour seems to be more favourable. Herein we present an acinic cell carcinoma arising on a background of typical and atypical microglandular adenosis in a 58-year-old woman, along with a review of the literature. PMID:24369519

Falleti, Jessica; Coletti, Gino; Rispoli, Ettore; Scarabeo, Francesca; Cervasio, Mariarosaria; Tornillo, Luigi; Pettinato, Guido; Insabato, Luigi

2013-01-01

403

Acinic Cell Carcinoma of the Breast Arising in Microglandular Adenosis  

PubMed Central

Acinic cell carcinoma is a rare breast tumour belonging to salivary gland-like tumours of the breast. They are “triple-negative” breast cancers even if their biological behaviour seems to be more favourable. Herein we present an acinic cell carcinoma arising on a background of typical and atypical microglandular adenosis in a 58-year-old woman, along with a review of the literature. PMID:24369519

Coletti, Gino; Rispoli, Ettore; Scarabeo, Francesca; Cervasio, Mariarosaria; Tornillo, Luigi; Pettinato, Guido; Insabato, Luigi

2013-01-01

404

Tumors and Pregnancy  

MedlinePLUS

Tumors during pregnancy are rare, but they can happen. Tumors can be either benign or malignant. Benign tumors aren't cancer. Malignant ones are. The most common cancers in pregnancy are breast cancer, cervical cancer, lymphoma, and melanoma. ...

405

Pancreatic islet cell tumor  

MedlinePLUS

Islet cell tumors; Islet of Langerhans tumor; Neuroendocrine tumors ... In the healthy pancreas, cells called islet cells produce hormones that regulate a several bodily functions. These include blood sugar level and the production of ...

406

Brain Tumor Statistics  

MedlinePLUS

... updates Please leave this field empty Brain Tumor Statistics SHARE Share on Facebook Preview your comments Share ... Close Finish Home > About Us > News > Brain Tumor Statistics Listen Brain Tumors do not discriminate. Primary brain ...

407

[Study on toxic effects of ammonia on embryonic and yolk-sac stage larvae of rare minnow].  

PubMed

To investigate the toxicity to fish which were exposed to ammonia during early life stages. This study choose rare minnow which is unique to China for experimental subject. Representative toxicological endpoints were observed and recorded during the development of embryo and yolk-sac stage larvae. Meanwhile, selected ammonia transporter protein Rhbg gene as a toxicity parameter to reflect the changes of rare minnow embryos Rhbg gene expression. The result shows that ammonia we have chosen in this research had an influence on many toxic effects including the hatching rate of fry, mortality rate, the slowing of heart rate and arrhythmia, unformed functional swim bladder, the decreasing of body length and weight and the occurrence of pericardium and yolk-sac edema etc. But other toxicological endpoints have relatively weak effect. The ammonia also affect the Rhbg gene expression changes, especially that of Rhbg gene at 72 hours post-fertilization distinctly. Rhbg may have important functions to facilitate ammonia transport during rare minnow embryo stages. PMID:22720585

Wang, Zhi-Jian; Lu, Zeng-Hui; Shi, Ping

2012-04-01

408

Assay and properties of rat yolk sac 25-hydroxyvitamin D/sub 3/ 1. cap alpha. -hydroxylase  

SciTech Connect

An in vitro assay has been developed for the rat yolk sac 25-hydroxyvitamin D/sub 3/ 1..cap alpha..-hydroxylase (1..cap alpha..-hydroxylase). The subcellular location and some properties of the enzyme are described. 1,25-Dihydroxyvitamin D/sub 3/ produced from incubations of yolk sac homogenates was extracted, purified by Sephadex LH-20 chromatography and straight- and reverse-phase high-performance liquid chromatography (HPLC), and measured by a competitive binding assay using chick intestinal receptor. The reaction is linear with time for up to 45 min at a substrate concentration of 80 ..mu..M and 4-6 mg/mL microsomal protein. The enzyme, located in the microsomes, requires molecular oxygen and NADPH. Metyrapone (1 x 10/sup -3/ M) was found to inhibit 1-hydroxylation, but a 90% carbon monoxide-10% oxygen atmosphere did not, leaving open the question of involvement of cytochrome P-450. Diphenyl-p-phenylenediamine, a lipid peroxidase inhibitor, inhibited 1..cap alpha..-hydroxylation.

Paulson, S.K.; Phelps, M.; DeLuca, H.F.

1986-11-04

409

CYP1A Induction and Blue SAC Disease in Early Developmental Stages of Rainbow Trout (Oncorhynchus Mykiss) Exposed to Retene.  

PubMed

Early life stages of rainbow trout were exposed to different regimes of water-borne retene (7-isopropyl-1-methylphenanthrene) to determine if there is an ontogenic stage particularly sensitive to retene toxicity, and if cytochrome P-4501A (CYP1A) induction is a forerunner to blue sac disease (BSD), the syndrome of toxicity. CYP1A protein concentrations, measured by immunohistochemistry, were first detected during organogenesis, when organ and enzyme systems are first being developed, and steadily increased until swim-up. The prevalence of signs of BSD rose 1 wk following a marked increase in CYP1A activity after hatch, suggesting that CYP1A induction is related to BSD. The larval stage was the most sensitive to retene toxicity, based on CYP1A induction and a high prevalence of BSD. The most common signs of BSD were hemorrhaging, yolk-sac edema, and mortality, but hemorrhaging was the first and most frequently observed response. Tissue concentrations of retene were elevated just after fertilization, but decreased steadily as fish developed to the swim-up stage, most likely due to the establishment of more efficient metabolic and excretory systems in later stages of development. PMID:12746134

Brinkworth, Lyndon; Hodson, Peter; Tabash, Samir; Lee, Patricia

2003-01-01

410

CYP1A induction and blue sac disease in early developmental stages of rainbow trout (Oncorhynchus Mykiss) exposed to retene.  

PubMed

Early life stages of rainbow trout were exposed to different regimes of water-borne retene (7-isopropyl-1-methylphenanthrene) to determine if there is an ontogenic stage particularly sensitive to retene toxicity, and if cytochrome P-4501A (CYP1A) induction is a forerunner to blue sac disease (BSD), the syndrome of toxicity. CYP1A protein concentrations, measured by immunohistochemistry, were first detected during organogenesis, when organ and enzyme systems are first being developed, and steadily increased until swim-up. The prevalence of signs of BSD rose 1 wk following a marked increase in CYP1A activity after hatch, suggesting that CYP1A induction is related to BSD. The larval stage was the most sensitive to retene toxicity, based on CYP1A induction and a high prevalence of BSD. The most common signs of BSD were hemorrhaging, yolk-sac edema, and mortality, but hemorrhaging was the first and most frequently observed response. Tissue concentrations of retene were elevated just after fertilization, but decreased steadily as fish developed to the swim-up stage, most likely due to the establishment of more efficient metabolic and excretory systems in later stages of development. PMID:12751390

Brinkworth, Lyndon C; Hodson, Peter V; Tabash, Samir; Lee, Patricia

2003-04-11

411

Diffuse ependymal dysembryoplastic neuroepithelial tumor causing spinal drop metastases: a case report.  

PubMed

Dysembryoplastic neuroepithelial tumors (DNETs) arise mostly in the supratentorial cerebral cortex. A very rare case of intraventricular DNET with diffuse ependymal involvement, which causes spinal drop metastasis, is presented. PMID:22778572

Kim, Seul Kee; Jeong, Min Young; Jung, Tae Young; Kang, Heoung Keun; Yoon, Woong

2012-01-01

412

Toxicity of parathion on embryo and yolk-sac larvae of gilthead seabream (Sparus aurata l.): effects on survival, cholinesterase, and carboxylesterase activity.  

PubMed

This study was conducted to examine the acute toxicity of the organophosphorus pesticide (OP) parathion on embryos and yolk-sac larvae of gilthead seabream (Sparus aurata), and to investigate the effects of this compound on cholinesterase and carboxylesterase activity of seabream larvae in the phase of endogenous feeding. The 72-h LC50 for yolk-sac larvae (0.523 mg L?¹) was about two-fold lower than the 48-h LC50 for embryos (1.005 mg L?¹). Parathion significantly inhibited the activity of ChE and CaE activity in yolk sac larvae but there were not significant differences in the sensitivity of both esterases to parathion as inferred by their 72-h IC50 values. Larvae exposed to parathion for 72 h showed a 70% inhibition of the whole body acetylcholinesterase at approximately the LC50. PMID:19565633

Arufe, M Isabel; Arellano, Juana M; Albendín, Gemma; Sarasquete, Carmen

2010-12-01

413

Enlarging Cells Initiating Apomixis in Hieracium praealtum Transition to an Embryo Sac Program prior to Entering Mitosis1[W][OPEN  

PubMed Central

Hieracium praealtum forms seeds asexually by apomixis. During ovule development, sexual reproduction initiates with megaspore mother cell entry into meiosis and formation of a tetrad of haploid megaspores. The sexual pathway ceases when a diploid aposporous initial (AI) cell differentiates, enlarges, and undergoes mitosis, forming an aposporous embryo sac that displaces sexual structures. Embryo and endosperm development in aposporous embryo sacs is fertilization independent. Transcriptional data relating to apomixis initiation in Hieracium spp. ovules is scarce and the functional identity of the AI cell relative to other ovule cell types is unclear. Enlarging AI cells with undivided nuclei, early aposporous embryo sacs containing two to four nuclei, and random groups of sporophytic ovule cells not undergoing these events were collected by laser capture microdissection. Isolated amplified messenger RNA samples were sequenced using the 454 pyrosequencing platform and comparatively analyzed to establish indicative roles of the captured cell types. Transcriptome and protein motif analyses showed that approximately one-half of the assembled contigs identified homologous sequences in Arabidopsis (Arabidopsis thaliana), of which the vast majority were expressed during early Arabidopsis ovule development. The sporophytic ovule cells were enriched in signaling functions. Gene expression indicative of meiosis was notably absent in enlarging AI cells, consistent with subsequent aposporous embryo sac formation without meiosis. The AI cell transcriptome was most similar to the early aposporous embryo sac transcriptome when comparing known functional annotations and both shared expressed genes involved in gametophyte development, suggesting that the enlarging AI cell is already transitioning to an embryo sac program prior to mitotic division. PMID:23864557

Okada, Takashi; Hu, Yingkao; Tucker, Matthew R.; Taylor, Jennifer M.; Johnson, Susan D.; Spriggs, Andrew; Tsuchiya, Tohru; Oelkers, Karsten; Rodrigues, Julio C.M.; Koltunow, Anna M.G.

2013-01-01

414

A case of trichoadenoma arising in the buttock.  

PubMed

A 41-year-old Japanese man with trichoadenoma on his buttock was described. Histological examination showed numerous horn cysts and some tumor islands consisting entirely of eosinophilic epithelial cells. A review of 24 reported cases of trichoadenoma revealed that most of them developed on the facial region (14 of 24 cases, 58%); the buttock (6 of 24, 25%) was the next most common site. PMID:1401511

Yamaguchi, J; Takino, C

1992-08-01

415

Primary liver carcinoma arising in people younger than 30 years.  

PubMed

Primary liver carcinomas in children and young adults are uncommon and poorly described. We examined primary liver carcinomas in people younger than 30 years and performed immunostains for markers of biliary (cytokeratin [CK] 7, CK19, CD56) and hepatocellular (HepPar) differentiation. We found 23 primary liver carcinomas were found: 13 hepatocellular carcinomas (HCCs), 9 fibrolamellar carcinomas (FLCs), and 1 cholangiocarcinoma. Most HCCs showed compact (n = 7) or trabecular (n = 4) growth patterns. The Edmondson grades were as follows: 1, 3 tumors; 2, 8 tumors; and 3, 2 tumors). All HCCs and FLCs were HepPar(+). All FLCs and 7 of 9 HCCs were CK7(+). In contrast, a control group of 65 adult HCCs showed less CK7 positivity (24 [37%]; P = .03). CK19 was positive in 2 HCCs and CD56 in 1 HCC. No chronic background liver disease was seen, although 3 cases showed foci of altered hepatocytes. HCCs are the most common primary liver carcinoma in children and young adults followed by FLCs. They are morphologically similar to adult HCC, but more likely to be CK7(+). PMID:16146811

Klein, Walter M; Molmenti, Ernesto P; Colombani, Paul M; Grover, Davinder S; Schwarz, Kathleen B; Boitnott, John; Torbenson, Michael S

2005-10-01

416

Neuroendocrine tumors: beyond the abdomen.  

PubMed

Several classification systems for neuroendocrine tumors (NETs) exist, which use variable terminology and criteria for grading and staging. This variability in terminology can cause confusion and difficulty in recognizing which tumors are, in fact, members of this heterogeneous group of malignancies. The largest group of NETs, the gastroenteropancreatic NETs, has been well described and characterized; however, there are less-recognized extra-abdominal NETs that can arise from nearly any organ in the body. In this article, the clinical features and imaging appearances of the extra-abdominal NETs will be reviewed, compared, and contrasted. This diverse group consists of paragangliomas, Merkel cell carcinomas, esthesioneuroblastomas, NETs of the lung, and medullary thyroid carcinomas. Recognition of these tumors as part of the larger group of NETs is important for understanding how best to approach imaging for their diagnosis, staging, and potential treatment. Familiarity with the computed tomographic and magnetic resonance imaging appearances and the role of radionuclide imaging of these heterogeneous groups aids in the correct diagnosis and in treatment planning. PMID:25162290

Jacobs, Melissa A; Weinstein, Stefanie; Hope, Thomas A; Aslam, Rizwan; Yee, Judy; Coakley, Fergus

2014-01-01

417

Observational constraints upon quintessence models arising from moduli fields  

E-print Network

We study observational constraints on cosmological models with a quintessence arising from moduli fields. The scalar field potential is given by a double exponential potential V=V_0 exp(-A e^{sqrt{2} kappa phi}). After reviewing the properties of the solutions, from a dynamical systems phase space analysis, we consider the constraints on parameter values imposed by luminosity distances from the 60 Type IA supernovae published by Perlmutter et al., and also from gravitational lensing statistics of distant quasars. We also update the constraints on models with a single exponential potential V=V_0 e^{-lambda kappa phi}.

S. C. C. Ng

2000-06-12

418

Orbital tumors: operative and therapeutic strategies.  

PubMed

The term "orbital tumors" includes diverse benign or malignant space-occupying lesions of the orbit, often leading to dystopia of the eyeball, motility disturbances, diplopia, visual field defects, and sometimes a complete loss of vision. Removing these tumors in a limited surgical field is challenging. Therefore, the preservation of function is a primary concern. We retrospectively reviewed 671 patients with orbital tumors from October 1999 to June 2014. Diagnosis on referral, presenting symptoms, radiological records, histology of the primary tumor or orbital metastasis, and treatment choice were analyzed. Among the 671 orbital tumors, 40% were accessed anteriorly, 36% via an orbitotomy with temporary osteotomy, and 23.9% underwent an orbital exenteration. As an illustration of the operative strategies with subsequent reconstructions, a distinction was made among the main indication groups: (1) function-preserving therapy for retrobulbar tumors, (2) malignant tumors of the conjunctiva and the eyelids, (3) exenteration of the orbit and subsequent reconstruction, and (4) operative and therapeutic strategy for orbital metastases. Adequate preoperative use of modern imaging techniques and thorough planning of the operation are crucial. Accurate histopathological diagnosis is crucial for planning appropriate therapeutic and surgical interventions. New innovative treatment concepts and surgical techniques arise from the close cooperation of related disciplines such as ophthalmology and neurosurgery. Although an orbital exenteration in patients with eyelid and conjunctival carcinomas can now often be avoided, eye-preserving treatment for locally advanced carcinomas of the conjunctiva and eyelid must be attempted. For extensive orbital malignancies, orbital exenteration is curative. In this context, primary closure of the orbit can improve the patient's quality of life and avoid subsequent complications. Concerning orbital metastasis, early diagnosis can preserve function and fulfil the esthetic demands of the patients. In palliative tumor disease, operative procedures such as orbital decompression or tumor debulking can reduce patient complaints and contribute to improved quality of life. PMID:25397713

Pförtner, R; Mohr, C; Daamen, J; Metz, A

2014-10-01

419

Squamous Cell Carcinoma Arising in a Mature Cystic Teratoma  

PubMed Central

Introduction. Malignant transformation in a mature cystic teratoma of the ovary is a rare complication. Squamous cell carcinoma is the most common transformation. We describe a new case of squamous cell carcinoma arising in a mature cystic teratoma. Case Report. A premenopausal 52-year-old female patient is diagnosed with vaginal bleeding. According to examination made on the women and the pelvic scanning, 7?cm mass is found on the right adnexa of the patient. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, pelvic lymph node dissection, and debulking were the treatments completed on the patient. According to histopathological diagnosis, squamous cell carcinoma arising in a mature cystic teratoma is diagnosed as a reason for the mass in the right adnexa of the patient. Conclusion. The prognosis of the malign transformation of MCT depends on surgery stage; however it is extremely poor. The patient should receive chemotherapy regardless of stage. We have decided to administer second cycle carboplatin and paclitaxel treatments on the patient. PMID:23320213

Avc?, Suna; Selcukbiricik, Fatih; Bilici, Ahmet; Özkan, Gülkan; Öza?ar?, Ayse Ay?im; Borlu, Fatih

2012-01-01

420

Neuroendocrine tumors of the gastrointestinal tract.  

PubMed

Neoplastic proliferations of neuroendocrine cells (NE) may occur throughout the entire GI tract but affect particularly appendix and ileum ("midgut carcinoids"), rectum ("hindgut carcinoids"), as well as stomach and the duodenum ("foregut carcinoids"). Only more exceptionally, they arise in the esophagus, jejunum and colon. The NE tumors encompass a heterogeneous gross and microscopic structural spectrum, ranging from inconspicuous microproliferations ("mucous membrane nevi") to bulky tumor masses. Their growth patterns are usually characteristic and easily recognized. In doubtful cases their NE differentiation becomes established by a characteristic silver affinity, by the ultrastructurally observed presence of characteristic "endocrine" secretion granules, and by immunohistochemically detectable occurrence of "pan-NE markers" (neuron-specific enolase, chromogranins, and synaptophysin), biogenic amines (mainly serotonin), and neurohormonal peptides. Foregut carcinoids usually contain serotonin, gastrin, and somatostatin, midgut carcinoids often only serotonin and tachykinins, whereas the hindgut carcinoids as a rule are multihormonal with a wide spectrum of hormonal peptides, including even insulin. Most GI NE tumors are found in the appendix (50%) and the ileum (30%). Practically all (98%) of the appendiceal NE tumors are benign. They have recently been proposed as arising from apparently Schwann-cell-related NE cells in the submucosa, whereas the ileal--and probably also all the other non-appendiceal NE tumors--are derived from the totipotential cells in epithelial crypts of the mucosa. Among the ileal NE neoplasms a large number can metastasize and result in a fatal outcome. The ability to metastasize is related to the size and to the multiplicity of the primary tumors at the time of initial diagnosis and, to some extent, to their histopathologic growth pattern. Now, some relationship between the prognosis and the cytochemically assessed nuclear DNA content of the NE tumor cells has also been established; not less than about 1/4 to 1/3 seem to be aneuploid. Almost 90% of the rectal carcinoids are benign. Exceptionally, a highly malignant NE neoplasms can arise from the colon/rectum--as well as from the esophagus--composed of NE cells of small and intermediate size. The NE tumors of the stomach are often composed of ECL (enterochromaffin-cell-like) cells; such ECL cell carcinoids are related to atrophic gastritis with pernicious anemia; experimentally, they can be induced by hypergastrinemia in rats. Duodenal carcinoids often contain psammoma bodies and can be associated with neurofibromatosis. PMID:3290866

Chejfec, G; Falkmer, S; Askensten, U; Grimelius, L; Gould, V E

1988-04-01

421

Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression  

PubMed Central

SUMMARY Neoantigens derived from somatic mutations in tumors may provide a critical link between the adaptive immune system and cancer. Here we describe a system to introduce exogenous antigens into genetically engineered mouse lung cancers to mimic tumor neoantigens. We show that endogenous T cells respond to and infiltrate tumors, significantly delaying malignant progression. Despite continued antigen expression, T cell infiltration does not persist and tumors ultimately escape immune attack. Transplantation of cell lines derived from these lung tumors or prophylactic vaccination against the autochthonous tumors, however, results in rapid tumor eradication or selection of tumors that lose antigen expression. These results provide insight into the dynamic nature of the immune response to naturally arising tumors. PMID:21251614

DuPage, Michel; Cheung, Ann; Mazumdar, Claire; Winslow, Monte M.; Bronson, Roderick; Schmidt, Leah M.; Crowley, Denise; Chen, Jianzhu; Jacks, Tyler

2010-01-01

422

Transcription factors GATA-4 and GATA-6, and their potential downstream effectors in ovarian germ cell tumors.  

PubMed

Ovarian germ cell tumors (GCTs) are histologically heterogeneous neoplasms originating from activated germ cells, the oocyte stem cells. These rare tumors often contain many different tissues mixed together, and malignant components are occasionally hidden within benign tissues thus complicating the diagnosis. The reasons for the variable differentiation of germ cells are still largely unknown. As transcription factors GATA-4 and GATA-6 as well as their downstream factors (e.g. HNF-4, BMP-2 and Ihh) are essential for normal yolk sac development, we studied their expression in 19 ovarian GCTs. Endodermal markers were expressed distinctively in different GCT types. The malignant endoderm in yolk sac tumors expressed all factors of endodermal development included in the study. Dysgerminomas, on the contrary, expressed only GATA-4 and, in a minority of cases, Ihh and BMP-2. The results suggest that GATA-4 and GATA-6 detected in the ovarian GCTs have retained their normal function. The fact that GATA-6 and HNF-4 are expressed exclusively in endodermal tissues indicates that these transcription factors play a role in the differentiation of germ cells towards the endodermal phenotype. Analysis of the nuclear transcription factors in tumor tissue could serve as a new informative diagnostic tool for ovarian GCTs. PMID:16110260

Mannisto, Susanna; Butzow, Ralf; Salonen, Jonna; Leminen, Arto; Heikinheimo, Oskari; Heikinheimo, Markku

2005-01-01

423

Middle Meningeal Artery Arising from the Basilar Artery  

PubMed Central

Various anomalies for the origin of the middle meningeal artery (MMA) have been described in the literature. However, origin of the MMA from the basilar trunk is an extremely rare variant. We report on a 54-year-old female who presented with frequent headaches; magnetic resonance imaging showed a right parietal meningioma. The abnormal origin of the middle meningeal artery from the basilar artery was diagnosed by angiography performed for preoperative embolization of the tumor. We report on the case with a review of the embryologic basis, possible explanations for this aberrant origin, and its clinical implications. PMID:25599045

Salem, Mohamed M.; Fusco, Matthew R.; Dolati, Parviz; Reddy, Arra S.; Ogilvy, Christopher S.; Thomas, Ajith J.

2014-01-01

424

Immune Escape Mechanisms of Intraocular Tumors  

PubMed Central

The notion that the immune system might control the growth of tumors was suggested over 100 years ago by the eminent microbiologist Paul Ehrlich. This concept was refined and expanded by Burnet and Thomas fifty years later with their articulation of the “immune surveillance” hypothesis. In its simplest form, the immune surveillance hypothesis suggests that neoplasms arise spontaneously and express novel antigens that are recognized by the immune system, which either eliminates the tumors or restrains their growth. Within the eye, immune responses are controlled and sometimes profoundly inhibited - a condition known as immune privilege. Immune privilege in the eye is the result of a complex array of anatomical, physiological, and immunoregulatory mechanisms that prevent the induction and expression of many immune responses. Tumors arising in the eye would seem to have an advantage in evading immune surveillance due to ocular immune privilege. Uveal melanoma, the most common and malignant intraocular tumor in adults not only benefits from the immune privilege of the eye, but has adopted many of the mechanisms that contribute to ocular immune privilege as a strategy for protecting uveal melanoma cells once they leave the sanctuary of the eye and are disseminated systemically in the form of metastases. Although the immune system possesses a battery of effector mechanisms designed to rid the body of neoplasms, tumors are capable of rapidly evolving and countering even the most sophisticated immunological effector mechanisms. To date, tumors seem to be winning this arms race, but an increased understanding of these mechanisms should provide insights for designing immunotherapy that was envisioned over half a century ago, but has failed to materialize to date. PMID:19563908

Niederkorn, Jerry Y.

2009-01-01

425

Design for a New Signal Analyzer through a Circuit Modeling Simulation as a One Body System for SAC's  

SciTech Connect

A circuit simulation analysis and diagnosis methods are used to diagnose instruments in detail when they give apparently abnormal readings. In this paper, a new simulator for analyzing the modeling of important circuits under SACs(severe accident conditions) has been designed. The realization of a one body system by using a one order command system in the LabVIEW and Pspice was used instead of a complex two body system. The program shows the output data from the circuit modeling according to a one order command system. The procedure for the simulator design was divided into two steps, of which the first step was the design of the diagnosis methods, and the second step was a circuit simulator for the signal processing tool and the special signal analysis tool. It has three main functions which are a signal processing tool, an accident management tool, and an additional guide from the initial screen. (authors)

Kil-Mo, Koo; Sang-Baik, Kim; Hee-Dong, Kim [Department of Thermal-Hydraulic Safety Research Team, KAERI, 150 Dukjin-dong, Yuseong, Daejeon, 305-353 (Korea, Republic of); Hae-Yong, Kang [Semiconductor Research Institute, Korea University, Daejeon (Korea, Republic of)

2006-07-01

426

Babbling behavior in the sac-winged bat (Saccopteryx bilineata)  

NASA Astrophysics Data System (ADS)

Infant babbling in humans and a few other primates plays an important role in allowing the young to practice the adult vocal repertoire during early behavioral development. Vocalizations uttered during babbling resemble, to some degree, the acoustic structure of adult vocalizations and are often produced in long bouts independent of any social context. Similar behavior, termed subsong or plastic song, is known from a variety of songbirds. Here, we show that pups of the sac-winged bat ( Saccopteryx bilineata), a species with an unusually large vocal repertoire, produce renditions of all known adult vocalization types during bouts of vocalizations, which appear to be independent of a distinct social context. Babbling occurs in pups of both sexes, even though only adult males, not females, utter all different vocalization types produced in infancy. To our knowledge, this is the first evidence of babbling in a nonprimate mammal and suggests that infant babbling may be necessary for the ontogeny of complex vocal repertoires.

Knörnschild, Mirjam; Behr, Oliver; von Helversen, Otto

2006-09-01

427

Development of a new code family based on SAC-OCDMA system with large cardinality for OCDMA network  

NASA Astrophysics Data System (ADS)

We have proposed a new Multi-Diagonal (MD) code for Spectral Amplitude - Coding Optical Code Division Multiple Access (SAC-OCDMA). Although this new MD code has many properties, one of the important properties of this code is that the cross correlation is always zero. Simplicity in code construction and flexibility in cross correlation control has made this code a compelling candidate for future OCDMA applications. The Multiple access interference (MAI) effects have been successfully and completely eliminated. Based on the theoretical analysis MD code is shown here to provide a much better performance compared to Modified Quadratic Congruence (MQC) code and Random Diagonal (RD) code. Proof-of-principle simulations of encoding with 5 and 10 users with 622 Mb/s data transmission at a BER of 10 -12 have been successfully demonstrated together with the DIRECT detection scheme.

Abd, Thanaa Hussein; Aljunid, S. A.; Fadhil, Hilal Adnan; Ahmad, R. A.; Saad, N. M.

2011-07-01

428

Theoretical investigation of EPR and molecular orbital coefficient parameters for [Cu(hsm) 2(sac) 2] complex  

NASA Astrophysics Data System (ADS)

In this study, the molecular orbital coefficients and the spin Hamiltonian parameters of bis(histamine-saccharinate) copper(II) complex, [Cu(hsm) 2(sac) 2], are calculated theoretically. Two d- d transition spectra and four EPR parameters g?,g?,A?,A? for the Cu(II) complex are calculated by using crystal-field theory. The calculated values are in good agreement with the experimental values. The g and A parameters have indicated that the paramagnetic centre is axially symmetric. Having the relations of g?>g?>ge and A?>A? for Cu 2+ ions, it can be concluded that Cu 2+ ions are located in distorted octahedral sites (D 4h) elongated along the z-axis and that the ground state of the paramagnetic electron is d ( 2B1g state).

Kalfao?lu, Emel; Karabulut, Bünyamin

2011-03-01

429

Aciniform spidroin, a constituent of egg case sacs and wrapping silk fibers from the black widow spider Latrodectus hesperus.  

PubMed

Spiders produce high performance fibers with diverse mechanical properties and biological functions. Molecular and biochemical studies of spider egg case silk have revealed that the main constituent of the large diameter fiber contains the fibroin TuSp1. Here we demonstrate by SDS-PAGE and protein silver staining the presence of a distinct approximately 300-kDa polypeptide that is found in solubilized egg case sacs. Combining matrix-assisted laser desorption ionization tandem time-of-flight mass spectrometry and reverse genetics, we have isolated a novel gene called AcSp1-like and demonstrate that its protein product is assembled into the small diameter fibers of egg case sacs and wrapping silks from the black widow spider, Latrodectus hesperus. BLAST searches of the NCBInr protein data base using the amino acid sequence of AcSp1-like revealed similarity to AcSp1, an inferred protein proposed to be a component of wrapping silk. However, the AcSp1-like protein was found to display more nonuniformity in its internal iterated repeat modules than the putative AcSp1 fibroin. Real time quantitative PCR analysis demonstrates that the AcSp1-like gene displays an aciniform gland-restricted pattern of expression. The amino acid composition of the fibroins extracted from the luminal contents of the aciniform glands was remarkably similar to the predicted amino acid composition of the AcSp1-like protein, which supports the assertion that AcSp1-like protein represents the major constituent stored within the aciniform gland. Collectively, our findings provide the first direct molecular evidence for the involvement of the aciniform gland in the production of a common fibroin that is assembled into the small diameter threads of egg case and wrapping silk of cob weavers. PMID:17921147

Vasanthavada, Keshav; Hu, Xiaoyi; Falick, Arnold M; La Mattina, Coby; Moore, Anne M F; Jones, Patrick R; Yee, Russell; Reza, Ryan; Tuton, Tiffany; Vierra, Craig

2007-11-30

430

DEVELOPMENT OF PROTOCOLS AND DECISION SUPPORT TOOLS FOR ASSESSING WATERSHED SYSTEM ASSIMILATIVE CAPACITY (SAC), IN SUPPORT OF RISK-BASED ECOSYSTEM MANAGEMENT/RESTORATION PRACTICES (TEXOMA PROJECT)  

EPA Science Inventory

Project funded through Ecosystem Restoration internal solicitation within NRMRL. This project will focus on Lake Texoma (located on the Oklahoma/Texas border) and the surrounding watershed to develop methods and protocols for assessing SAC, and to evaluate its potential for use ...

431

Comparative study of bacterial status from conjunctival sac of the elder Qiang minority and Han people with dry eye in Sichuan, China  

PubMed Central

AIM To compare the status of bacteria in the conjunctival sac from the elder Qiang minority and Han people with dry eyes in Sichuan, China. METHODS Total of 54 elder Qiang people with dry eyes (108 eyes) were examined by cluster sampling. In the similar habitation region of Han people, 80 (160 dry eyes) Han people were analyzed as the control group. The bacteria was separated from the inferior palpebral conjunctiva, then inoculated on blood plate for 48 hours and identified. RESULTS Totally 24 strains of bacteria were cultured in either Qiang minority or Han c populations with 3 strains of them existed in both ethnic groups. The commonest bacteria in conjunctival sac in two ethnic groups were non-pathogenic bacterium. The composition of Corynebacterium in Han people (54.1%) was significantly higher than that in Qiang minority (27.4%) (?2=11.6721, P=0.0006). The percentage of Sphingomonas Paucimobilis in Qiang people was higher than that in Han people (?2=18.6442, P=0.0000). However, there was no significant difference between Qiang minority and Han people either in bacterial positive rate in conjunctival sac, or the composition of bacteria species and strains, or the composition of staphylococcus epidemids between two ethnic populations. CONCLUSION There was no significant difference of bacterial positive rate in conjunctival sac from the elder of Qiang minority and Han people with dry eye, but the species of bacteria were different. PMID:22773985

Zhang, Yue; Liu, Zhi-Rong; Chen, Hui; Dong, Wan-Jiang; Fan, Ying-Chuan; Yu, Hua; Wang, Guang-Jin; Li, Yu-Chan; Cao, Kui

2012-01-01

432

Truncation of a Protein Disulfide Isomerase, PDIL2-1, Delays Embryo Sac Maturation and Disrupts Pollen Tube Guidance in Arabidopsis thaliana  

Technology Transfer Automated Retrieval System (TEKTRAN)

Pollen tubes navigate through different female tissues and deliver the sperm to the embryo sac for fertilization. Protein disulfide isomerases play important roles in the maturation of secreted or plasma membrane proteins. Here we show that truncated versions of a protein disulfide isomerase (PDI), ...

433

[A case of adenocarcinoma arising in an ileal conduit].  

PubMed

We report a rare case of adenocarcinoma developing in an ileal conduit. A 78-year-old woman was referred complaining of abdominal pain. She had undergone radical cystectomy and ileal conduit formation for invasive bladder cancer 8 years previously. The pathological diagnosis was urothelial carcinoma, and distant metastasis was not found. She was lost to follow-up over 2 years postoperatively. Computed tomography at this time showed bilateral hydronephrosis. Metastasis was not revealed. Because renal failure progressed and gross hematuria developed, endoscopic examination through the stoma was performed. A mass adjacent to the ureteroileal anastomosis site was found. Biopsy led to a diagnosis of moderately differentiated adenocarcinoma. She died of renal failure 1.5 months after admission. To our knowledge, 9 cases of adenocarcinoma arising in an ileal conduit have previously been reported. PMID:23719138

Mizusawa, Hiroya; Mimura, Yuji; Saito, Tetsuichi

2013-05-01

434

Irregular activity arises as a natural consequence of synaptic inhibition  

SciTech Connect

Irregular neuronal activity is observed in a variety of brain regions and states. This work illustrates a novel mechanism by which irregular activity naturally emerges in two-cell neuronal networks featuring coupling by synaptic inhibition. We introduce a one-dimensional map that captures the irregular activity occurring in our simulations of conductance-based differential equations and mathematically analyze the instability of fixed points corresponding to synchronous and antiphase spiking for this map. We find that the irregular solutions that arise exhibit expansion, contraction, and folding in phase space, as expected in chaotic dynamics. Our analysis shows that these features are produced from the interplay of synaptic inhibition with sodium, potassium, and leak currents in a conductance-based framework and provides precise conditions on parameters that ensure that irregular activity will occur. In particular, the temporal details of spiking dynamics must be present for a model to exhibit this irregularity mechanism and must be considered analytically to capture these effects.

Terman, D., E-mail: terman@math.ohio-state.edu [Department of Mathematics, The Ohio State University, Columbus, Ohio 43210 (United States); Rubin, J. E., E-mail: jonrubin@pitt.edu [Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 (United States); Diekman, C. O., E-mail: diekman@njit.edu [Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, New Jersey 07102 (United States)

2013-12-15

435

Central and Peripheral Retina Arise through Distinct Developmental Paths  

PubMed Central

In the mature eye, three distinct tissue fates, retina, ciliary body, and iris, arrange with a strict linear organization along the central (back) to peripheral (front) axis. The establishment of this topographical relationship within the optic vesicle is not well understood. We use a targeted vital labeling strategy to test the derivation of mature eye tissues from the optic vesicle of the chick embryo. Fate mapping uncovers two distinct origins of the neural retina. Contrary to expectations, the central neural retina has a discrete origin within the posterior optic vesicle. The peripheral retina derives from the distal optic vesicle, sharing a common origin with more peripheral tissue fates. This study identifies for the first time two distinct retinal sub-domains, central and peripheral, which arise during embryogenesis. Identification of these discrete retinal compartments provides a framework for understanding functional and disease processes throughout retinal tissue. PMID:23613848

Venters, Sara J.; Mikawa, Takashi; Hyer, Jeanette

2013-01-01

436

Stromal tumor of the lesser omentum : a case report  

PubMed Central

Gastrointestinal stromal tumors (GISTs) represent the majority of primary non-epithelial neoplasms of the digestive tract, most frequently expressing the KIT protein detected by immunohistochemical staining for the CD117 antigen. Extragastrointestinal stromal tumors (EGISTs), neoplasms with immunohistological features overlapping those of GISTs, are found in the abdomen outside of the gastrointestinal tract with no connection to the gastric or intestinal wall. We report the clinical, macroscopic and immunohistological features of an EGIST arising in the lesser omentum of a 58-year-old woman. This is a very rare location of intra abdominal stromal tumors. PMID:25170380

Behammane, Hossam; Aggouri, Younes; Oussaid, Morad; Laalim, Said Ait; Toughrai, Imane; majdoub, Karim Ibn; Mazaz, Khalid

2014-01-01

437

Stromal tumor of the lesser omentum : a case report.  

PubMed

Gastrointestinal stromal tumors (GISTs) represent the majority of primary non-epithelial neoplasms of the digestive tract, most frequently expressing the KIT protein detected by immunohistochemical staining for the CD117 antigen. Extragastrointestinal stromal tumors (EGISTs), neoplasms with immunohistological features overlapping those of GISTs, are found in the abdomen outside of the gastrointestinal tract with no connection to the gastric or intestinal wall. We report the clinical, macroscopic and immunohistological features of an EGIST arising in the lesser omentum of a 58-year-old woman. This is a very rare location of intra abdominal stromal tumors. PMID:25170380

Behammane, Hossam; Aggouri, Younes; Oussaid, Morad; Laalim, Said Ait; Toughrai, Imane; Ibn majdoub, Karim; Mazaz, Khalid

2014-01-01

438

Primitive Neuroectodermal Tumor with Kidney Involvement: A Case Report  

PubMed Central

Primitive neuroectodermal tumor (PNET) is usually an aggressive, rapidly progressing and metastasizing tumor. Occurrence of this type of tumor in the kidney is considered as unusual and few cases have been reported so far. We present a metastatic PNET arising probably from the kidney in a 17-year-old female patient with local invasion and metastasis to the stomach. PNET should be considered as a differential diagnosis of a large heterogeneous soft tissue mass in the abdomen, especially in those with widely local invasion and metastases. PMID:25035703

Sharifi Doloui, Davood; Fakharian, Tahereh; Yahyavi, Vahid; Nekooei, Sirous; Zivarifar, Hamid Reza; Ghafarzadegan, Kamran

2014-01-01

439

Malignant peripheral nerve sheath tumor of the parotid gland.  

PubMed

Malignant peripheral nerve sheath tumor (MPNST) refers to spindle cell sarcomas arising from or separating in the direction of cells of the peripheral nerve sheath. The MPNST of the parotid gland is an extremely rare tumor, usually having a poor prognosis, and only a few cases been described in the literature. In this article, we report the diagnostic and therapeutic challenges related to a new case of MPNST of the parotid. Diagnosis was made based on clinical, imaging (computed tomography scan), histologic, and immunohistochemistry findings. Despite comprehensive treatment--complete surgical resection and radiotherapy--the tumor displayed a highly aggressive course. PMID:25153067

Chis, Octavian; Albu, Silviu

2014-09-01

440

A tale of two tumors: treating pancreatic and extrapancreatic neuroendocrine tumors.  

PubMed

Despite their perceived rarity, gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rising in incidence and prevalence. The biology, natural history, and therapeutic options for GEP-NETs are heterogeneous: NETs arising in the pancreas can be distinguished from those arising elsewhere in the gastrointestinal tract, and therapy is dichotomized between these two groups. Somatostatin analogues are the mainstay of oncologic management of bowel NETs; everolimus, streptozocin, and sunitinib are approved to treat pancreatic NETs. There are significant differences in molecular genetics between pancreatic and extrapancreatic NETs, and studies are evaluating whether additional NET patients may benefit from targeted agents. We discuss the distinguishing features of these two groups of tumors, as well as the therapeutic implications of the distinction. We also examine the evolving therapeutic landscape and discuss the likelihood that treatment will be developed independently for pancreatic and extrapancreatic gastrointestinal NETs, with novel therapeutics effective for newly identified pathologically or molecularly defined subgroups. PMID:25341008

Halperin, Daniel M; Kulke, Matthew H; Yao, James C

2015-01-14

441

Tumor microenvironment and nanotherapeutics  

PubMed Central

Recent studies delineate a predominant role for the tumor microenvironment in tumor growth and progression. Improved knowledge of cancer biology and investigation of the complex functional interrelation between the cellular and noncellular compartments of the tumor microenvironment have provided an ideal platform for the evolution of novel cancer nanotherapies. In addition, multifunctional “smart” nanoparticles carrying imaging agents and delivering multiple drugs targeted preferentially to the tumor/tumor microenvironment will lead to early diagnosis and better treatment for patients with cancer. The emerging knowledge of the tumor microenvironment has enabled rational designing of nanoparticles for combinatorial treatment strategies that include radiotherapy, antiangiogenesis and chemotherapy. This multimodality approach is thus expected to achieve therapeutic efficacy and enhance the quality of life of cancer patients. This review highlights the unique characteristics of the tumor microenvironment that are exploited by nanotechnology to develop novel drug delivery systems aimed to target the tumor/tumor microenvironment. PMID:24634853

Upreti, Meenakshi; Jyoti, Amar; Sethi, Pallavi

2014-01-01

442

Tumor Macroenvironment and Metabolism  

PubMed Central

In this review we introduce the concept of the tumor macroenvironment and explore it in the context of metabolism. Tumor cells interact with the tumor microenvironment including immune cells. Blood and lymph vessels are the critical components that deliver nutrients to the tumor and also connect the tumor to the macroenvironment. Several factors are then released from the tumor itself but potentially also from the tumor microenvironment, influencing the metabolism of distant tissues and organs. Amino acids, and distinct lipid and lipoprotein species can be essential for further tumor growth. The role of glucose in tumor metabolism has been studied extensively. Cancer-associated cachexia is the most important tumor-associated systemic syndrome and not only affects the quality of life of patients with various malignancies but is estimated to be the cause of death in 15%–20% of all cancer patients. On the other hand, systemic metabolic diseases such as obesity and diabetes are known to influence tumor development. Furthermore, the clinical implications of the tumor macroenvironment are explored in the context of the patient’s outcome with special consideration for pediatric tumors. Finally, ways to target the tumor macroenvironment that will provide new approaches for therapeutic concepts are described. PMID:24787299

Al-Zhoughbi, Wael; Huang, Jianfeng; Paramasivan, Ganapathy S.; Till, Holger; Pichler, Martin; Guertl-Lackner, Barbara; Hoefler, Gerald

2014-01-01

443

Tumor macroenvironment and metabolism.  

PubMed

In this review we introduce the concept of the tumor macroenvironment and explore it in the context of metabolism. Tumor cells interact with the tumor microenvironment including immune cells. Blood and lymph vessels are the critical components that deliver nutrients to the tumor and also connect the tumor to the macroenvironment. Several factors are then released from the tumor itself but potentially also from the tumor microenvironment, influencing the metabolism of distant tissues and organs. Amino acids, and distinct lipid and lipoprotein species can be essential for further tumor growth. The role of glucose in tumor metabolism has been studied extensively. Cancer-associated cachexia is the most important tumor-associated systemic syndrome and not only affects the quality of life of patients with various malignancies but is estimated to be the cause of death in 15%-20% of all cancer patients. On the other hand, systemic metabolic diseases such as obesity and diabetes are known to influence tumor development. Furthermore, the clinical implications of the tumor macroenvironment are explored in the context of the patient's outcome with special consideration for pediatric tumors. Finally, ways to target the tumor macroenvironment that will provide new approaches for therapeutic concepts are described. PMID:24787299

Al-Zoughbi, Wael; Al-Zhoughbi, Wael; Huang, Jianfeng; Paramasivan, Ganapathy S; Till, Holger; Pichler, Martin; Guertl-Lackner, Barbara; Hoefler, Gerald

2014-04-01

444

Uterine mast cell tumor: a clinical and cytohistopathological study.  

PubMed

BackgroundMast cells are one of the characteristic factors in angiogenesis, growth, and metastatic spread of tumors. Further studies are suggested to determine the type of these cells which might be useful in the assessment of biological nature of the tumor and its future treatment modality. Few studies have evaluated mast cell infiltration in visceral tumors, especially uterine tumors.Case presentationIn this study, age, sex, death rate, and histologic patterns were in agreement with those of previous reports on canine mast cell tumors. Cytopathology assays are widely used to prognosticate canine uterine mast cell tumors (MCT). There is limited information about these prognostic assays used on MCT that arise in the uterine. The anisocytosis and anisocytosis and giant cells were present in the tumor. Furthermore, the tumor had nuclear atypia with scattered multinucleated cells and prominent nucleoli and tumor were classified as poorly granulated. Under microscopic examination, we observed diffuse infiltration and proliferation of tumor cells from the uterine different area and the infiltrative characteristics and distribution patterns of neoplastic cells were observed. This tumor consisted of sheets and cords of uniform round cells with discrete cytoplasmic margins. Microscopically, the neoplastic masses were poorly-demarcated and lacked capsules and tumor cell usually showed a distinct cell boundary. Nevertheless, the neoplastic cells were located between collagen bundles forming small clusters and sheets and had large, centrally located, round to ovoid nuclei. In addition, eosinophils were scattered among the mast cells at the periphery of the masses. The presence of eosinophils and the observation, at high magnification, of cells with cytoplasmic metachromatic granules.ConclusionBased on these findings, a diagnosis of poorly-differentiated mast cell tumor was made and data histologic grading was available for tumor. Neoplasm was poorly differentiated or gradeIII. PMID:25376173

Bahrami, Ali; Khaki, Fariba; Zehtabian, Shahram; Cheraghi, Javad; Rashnavadi, Mehdi; Ahmadi, Mohammad; Naderafif, Mostafa; Javaherypour, Soheil; Mohsenzadeh, Siamak; Hosseini, Ehsan; Masoudi, Hamed; Pourzaer, Mehdi

2014-11-01

445

Primary solitary fibrous tumor (SFT) in the retroperitoneum  

Microsoft Academic Search

BackgroundSolitary fibrous tumor (SFT) is an infrequent but distinct neoplasm, which generally arises from submesothelial connective tissue in the pleura. SFT is rarely recognized in extrathoracic sites, and histologically identical conditions have also been reported in the retroperitoneum, although their pathophysiology has not been extensively investigated.

Itsuhiro Takizawa; Toshihiro Saito; Yasuo Kitamura; Kei Arai; Makoto Kawaguchi; Kota Takahashi; Noboru Hara

2008-01-01

446

Primary adenoid cystic carcinoma: an extremely rare eyelid tumor.  

PubMed

Cutaneous adenoid cystic carcinoma is an extremely rare clinical entity. Among the few cases reported in the literature, most had contiguous involvement from the lacrimal gland. Primary adenoid cystic carcinoma is one of the rarest eyelid tumors. The authors report a case of adenoid cystic carcinoma arising from the lower eyelid. PMID:21629138