Science.gov

Sample records for safety assessment methodologies

  1. Indirect Lightning Safety Assessment Methodology

    SciTech Connect

    Ong, M M; Perkins, M P; Brown, C G; Crull, E W; Streit, R D

    2009-04-24

    Lightning is a safety hazard for high-explosives (HE) and their detonators. In the However, the current flowing from the strike point through the rebar of the building The methodology for estimating the risk from indirect lighting effects will be presented. It has two parts: a method to determine the likelihood of a detonation given a lightning strike, and an approach for estimating the likelihood of a strike. The results of these two parts produce an overall probability of a detonation. The probability calculations are complex for five reasons: (1) lightning strikes are stochastic and relatively rare, (2) the quality of the Faraday cage varies from one facility to the next, (3) RF coupling is inherently a complex subject, (4) performance data for abnormally stressed detonators is scarce, and (5) the arc plasma physics is not well understood. Therefore, a rigorous mathematical analysis would be too complex. Instead, our methodology takes a more practical approach combining rigorous mathematical calculations where possible with empirical data when necessary. Where there is uncertainty, we compensate with conservative approximations. The goal is to determine a conservative estimate of the odds of a detonation. In Section 2, the methodology will be explained. This report will discuss topics at a high-level. The reasons for selecting an approach will be justified. For those interested in technical details, references will be provided. In Section 3, a simple hypothetical example will be given to reinforce the concepts. While the methodology will touch on all the items shown in Figure 1, the focus of this report is the indirect effect, i.e., determining the odds of a detonation from given EM fields. Professor Martin Uman from the University of Florida has been characterizing and defining extreme lightning strikes. Using Professor Uman's research, Dr. Kimball Merewether at Sandia National Laboratory in Albuquerque calculated the EM fields inside a Faraday-cage type

  2. Safety assessment of adjuvanted vaccines: Methodological considerations

    PubMed Central

    Da Silva, Fernanda Tavares; Di Pasquale, Alberta; Yarzabal, Juan P; Garçon, Nathalie

    2015-01-01

    Adjuvants mainly interact with the innate immune response and are used to enhance the quantity and quality of the downstream adaptive immune response to vaccine antigens. Establishing the safety of a new adjuvant-antigen combination is achieved through rigorous evaluation that begins in the laboratory, and that continues throughout the vaccine life-cycle. The strategy for the evaluation of safety pre-licensure is guided by the disease profile, vaccine indication, and target population, and it is also influenced by available regulatory guidelines. In order to allow meaningful interpretation of clinical data, clinical program methodology should be optimized and standardized, making best use of all available data sources. Post-licensure safety activities are directed by field experience accumulated pre- and post-licensure clinical trial data and spontaneous adverse event reports. Continued evolution of safety evaluation processes that keep pace with advances in vaccine technology and updated communication of the benefit-risk profile is necessary to maintain public confidence in vaccines. PMID:26029975

  3. Safety assessment of adjuvanted vaccines: Methodological considerations.

    PubMed

    Da Silva, Fernanda Tavares; Di Pasquale, Alberta; Yarzabal, Juan P; Garçon, Nathalie

    2015-01-01

    Adjuvants mainly interact with the innate immune response and are used to enhance the quantity and quality of the downstream adaptive immune response to vaccine antigens. Establishing the safety of a new adjuvant-antigen combination is achieved through rigorous evaluation that begins in the laboratory, and that continues throughout the vaccine life-cycle. The strategy for the evaluation of safety pre-licensure is guided by the disease profile, vaccine indication, and target population, and it is also influenced by available regulatory guidelines. In order to allow meaningful interpretation of clinical data, clinical program methodology should be optimized and standardized, making best use of all available data sources. Post-licensure safety activities are directed by field experience accumulated pre- and post-licensure clinical trial data and spontaneous adverse event reports. Continued evolution of safety evaluation processes that keep pace with advances in vaccine technology and updated communication of the benefit-risk profile is necessary to maintain public confidence in vaccines. PMID:26029975

  4. Improvement of Safety Assessment Methodologies for Near Surface Disposal Facilities

    SciTech Connect

    Batandjieva, B.; Torres-Vidal, C.

    2002-02-26

    The International Atomic Energy Agency (IAEA) Coordinated research program ''Improvement of Safety Assessment Methodologies for Near Surface Disposal Facilities'' (ISAM) has developed improved safety assessment methodology for near surface disposal facilities. The program has been underway for three years and has included around 75 active participants from 40 countries. It has also provided examples for application to three safety cases--vault, Radon type and borehole radioactive waste disposal facilities. The program has served as an excellent forum for exchange of information and good practices on safety assessment approaches and methodologies used worldwide. It also provided an opportunity for reaching broad consensus on the safety assessment methodologies to be applied to near surface low and intermediate level waste repositories. The methodology has found widespread acceptance and the need for its application on real waste disposal facilities has been clearly identified. The ISAM was finalized by the end of 2000, working material documents are available and an IAEA report will be published in 2002 summarizing the work performed during the three years of the program. The outcome of the ISAM program provides a sound basis for moving forward to a new IAEA program, which will focus on practical application of the safety assessment methodologies to different purposes, such as licensing radioactive waste repositories, development of design concepts, upgrading existing facilities, reassessment of operating repositories, etc. The new program will also provide an opportunity for development of guidance on application of the methodology that will be of assistance to both safety assessors and regulators.

  5. An Integrated Safety Assessment Methodology for Generation IV Nuclear Systems

    SciTech Connect

    Timothy J. Leahy

    2010-06-01

    The Generation IV International Forum (GIF) Risk and Safety Working Group (RSWG) was created to develop an effective approach for the safety of Generation IV advanced nuclear energy systems. Early work of the RSWG focused on defining a safety philosophy founded on lessons learned from current and prior generations of nuclear technologies, and on identifying technology characteristics that may help achieve Generation IV safety goals. More recent RSWG work has focused on the definition of an integrated safety assessment methodology for evaluating the safety of Generation IV systems. The methodology, tentatively called ISAM, is an integrated “toolkit” consisting of analytical techniques that are available and matched to appropriate stages of Generation IV system concept development. The integrated methodology is intended to yield safety-related insights that help actively drive the evolving design throughout the technology development cycle, potentially resulting in enhanced safety, reduced costs, and shortened development time.

  6. Evaluation of safety assessment methodologies in Rocky Flats Risk Assessment Guide (1985) and Building 707 Final Safety Analysis Report (1987)

    SciTech Connect

    Walsh, B.; Fisher, C.; Zigler, G.; Clark, R.A.

    1990-11-09

    FSARs. Rockwell International, as operating contractor at the Rocky Flats plant, conducted a safety analysis program during the 1980s. That effort resulted in Final Safety Analysis Reports (FSARs) for several buildings, one of them being the Building 707 Final Safety Analysis Report, June 87 (707FSAR) and a Plant Safety Analysis Report. Rocky Flats Risk Assessment Guide, March 1985 (RFRAG85) documents the methodologies that were used for those FSARs. Resources available for preparation of those Rocky Flats FSARs were very limited. After addressing the more pressing safety issues, some of which are described below, the present contractor (EG&G) intends to conduct a program of upgrading the FSARs. This report presents the results of a review of the methodologies described in RFRAG85 and 707FSAR and contains suggestions that might be incorporated into the methodology for the FSAR upgrade effort.

  7. Development and application of a safety assessment methodology for waste disposals

    SciTech Connect

    Little, R.H.; Torres, C.; Schaller, K.H.

    1996-12-31

    As part of a European Commission funded research programme, QuantiSci (formerly the Environmental Division of Intera Information Technologies) and Instituto de Medio Ambiente of the Centro de Investigaciones Energeticas Medioambientales y Tecnologicas (IMA/CIEMAT) have developed and applied a comprehensive, yet practicable, assessment methodology for post-disposal safety assessment of land-based disposal facilities. This Safety Assessment Comparison (SACO) Methodology employs a systematic approach to the collection, evaluation and use of waste and disposal system data. It can be used to assess engineered barrier performance, the attenuating properties of host geological formations, and the long term impacts of a facility on the environment and human health, as well as allowing the comparison of different disposal options for radioactive, mixed and non-radioactive wastes. This paper describes the development of the methodology and illustrates its use.

  8. Development of a methodology for assessing the safety of embedded software systems

    NASA Technical Reports Server (NTRS)

    Garrett, C. J.; Guarro, S. B.; Apostolakis, G. E.

    1993-01-01

    A Dynamic Flowgraph Methodology (DFM) based on an integrated approach to modeling and analyzing the behavior of software-driven embedded systems for assessing and verifying reliability and safety is discussed. DFM is based on an extension of the Logic Flowgraph Methodology to incorporate state transition models. System models which express the logic of the system in terms of causal relationships between physical variables and temporal characteristics of software modules are analyzed to determine how a certain state can be reached. This is done by developing timed fault trees which take the form of logical combinations of static trees relating the system parameters at different point in time. The resulting information concerning the hardware and software states can be used to eliminate unsafe execution paths and identify testing criteria for safety critical software functions.

  9. Safety Assessment for a Surface Repository in the Chernobyl Exclusion Zone - Methodology for Assessing Disposal under Intervention Conditions - 13476

    SciTech Connect

    Haverkamp, B.; Krone, J.; Shybetskyi, I.

    2013-07-01

    The Radioactive Waste Disposal Facility (RWDF) Buryakovka was constructed in 1986 as part of the intervention measures after the accident at Chernobyl NPP (ChNPP). Today, RWDF Buryakovka is still being operated but its maximum capacity is nearly reached. Plans for enlargement of the facility exist since more than 10 years but have not been implemented yet. In the framework of an European Commission Project DBE Technology GmbH prepared a safety analysis report of the facility in its current state (SAR) and a preliminary safety analysis report (PSAR) based on the planned enlargement. Due to its history RWDF Buryakovka does not fully comply with today's best international practices and the latest Ukrainian regulations in this area. The most critical aspects are its inventory of long-lived radionuclides, and the non-existent multi-barrier waste confinement system. A significant part of the project was dedicated, therefore, to the development of a methodology for the safety assessment taking into consideration the facility's special situation and to reach an agreement with all stakeholders involved in the later review and approval procedure of the safety analysis reports. Main aspect of the agreed methodology was to analyze the safety, not strictly based on regulatory requirements but on the assessment of the actual situation of the facility including its location within the Exclusion Zone. For both safety analysis reports, SAR and PSAR, the assessment of the long-term safety led to results that were either within regulatory limits or within the limits allowing for a specific situational evaluation by the regulator. (authors)

  10. Development and methodology of level 1 probability safety assessment at PUSPATI TRIGA Reactor

    NASA Astrophysics Data System (ADS)

    Maskin, Mazleha; Tom, Phongsakorn Prak; Lanyau, Tonny Anak; Brayon, Fedrick Charlie Matthew; Mohamed, Faizal; Saad, Mohamad Fauzi; Ismail, Ahmad Razali; Abu, Mohamad Puad Haji

    2014-02-01

    As a consequence of the accident at the Fukushima Dai-ichi Nuclear Power Plant in Japan, the safety aspects of the one and only research reactor (31 years old) in Malaysia need be reviewed. Based on this decision, Malaysian Nuclear Agency in collaboration with Atomic Energy Licensing Board and Universiti Kebangsaan Malaysia develop a Level-1 Probability Safety Assessment on this research reactor. This work is aimed to evaluate the potential risks of incidents in RTP and at the same time to identify internal and external hazard that may cause any extreme initiating events. This report documents the methodology in developing a Level 1 PSA performed for the RTP as a complementary approach to deterministic safety analysis both in neutronics and thermal hydraulics. This Level-1 PSA work has been performed according to the procedures suggested in relevant IAEA publications and at the same time numbers of procedures has been developed as part of an Integrated Management System programme implemented in Nuclear Malaysia.

  11. Development and methodology of level 1 probability safety assessment at PUSPATI TRIGA Reactor

    SciTech Connect

    Maskin, Mazleha; Tom, Phongsakorn Prak; Lanyau, Tonny Anak; Saad, Mohamad Fauzi; Ismail, Ahmad Razali; Abu, Mohamad Puad Haji; Brayon, Fedrick Charlie Matthew; Mohamed, Faizal

    2014-02-12

    As a consequence of the accident at the Fukushima Dai-ichi Nuclear Power Plant in Japan, the safety aspects of the one and only research reactor (31 years old) in Malaysia need be reviewed. Based on this decision, Malaysian Nuclear Agency in collaboration with Atomic Energy Licensing Board and Universiti Kebangsaan Malaysia develop a Level-1 Probability Safety Assessment on this research reactor. This work is aimed to evaluate the potential risks of incidents in RTP and at the same time to identify internal and external hazard that may cause any extreme initiating events. This report documents the methodology in developing a Level 1 PSA performed for the RTP as a complementary approach to deterministic safety analysis both in neutronics and thermal hydraulics. This Level-1 PSA work has been performed according to the procedures suggested in relevant IAEA publications and at the same time numbers of procedures has been developed as part of an Integrated Management System programme implemented in Nuclear Malaysia.

  12. [Physical principles, methodology, consistency, and safety in Doppler assessment of the fetal-placental circulation].

    PubMed

    Medina Castro, Néstor; Moreno Alvarez, Oscar; Guzmán Huerta, Mario; Hernández Andrade, Edgar

    2007-10-01

    Introduction of Doppler ultrasound in obstetrical practice has changed both management and understanding of several diseases that put at risk women and them fetuses. To establish necessary basics and correctly apply this technique, this review will focus in physical principles, acquisition methods, consistency, and safety issues of Doppler ultrasound, in order to improve precision, accuracy and interpretation of this methodology. PMID:18800581

  13. A Safety Risk Assessment Methodology for Decision Support Systems with an Application to the Expedite Departure Path Tool

    NASA Technical Reports Server (NTRS)

    Snyder, Phillip T.; Landis, Michael R. (Technical Monitor)

    2001-01-01

    In support of the NASA Advanced Air Transportation Technologies Project, the Volpe National Transportation Systems Center has developed a methodology to perform safety risk assessments for air traffic control/air traffic management decision Support systems and concepts. Changes in controller, pilot, and/or airline dispatcher tasks that are affected by the decision support system are related to associated hazards. These hazards are then assessed either qualitatively or quantitatively in terms of likelihood of occurring and the impact if they do occur. Those items that show a potential safety hazard level increase can then have research plans developed to address those safety risks areas. An application of this methodology will he demonstrated using the AATT decision support tool Expedite Departure Path.

  14. A Comparison of the Safety Analysis Process and the Generation IV Proliferation Resistance/Physical Protection Assessment Methodology

    SciTech Connect

    T. A. Bjornard; M. D. Zentner

    2006-05-01

    The Generation IV International Forum (GIF) is a vehicle for the cooperative international development of future nuclear energy systems. The Generation IV program has established primary objectives in the areas of sustainability, economics, safety and reliability, and Proliferation Resistance and Physical Protection (PR&PP). In order to help meet the latter objective a program was launched in December 2002 to develop a rigorous means to assess nuclear energy systems with respect to PR&PP. The study of Physical Protection of a facility is a relatively well established methodology, but an approach to evaluate the Proliferation Resistance of a nuclear fuel cycle is not. This paper will examine the Proliferation Resistance (PR) evaluation methodology being developed by the PR group, which is largely a new approach and compare it to generally accepted nuclear facility safety evaluation methodologies. Safety evaluation methods have been the subjects of decades of development and use. Further, safety design and analysis is fairly broadly understood, as well as being the subject of federally mandated procedures and requirements. It is therefore extremely instructive to compare and contrast the proposed new PR evaluation methodology process with that used in safety analysis. By so doing, instructive and useful conclusions can be derived from the comparison that will help to strengthen the PR methodological approach as it is developed further. From the comparison made in this paper it is evident that there are very strong parallels between the two processes. Most importantly, it is clear that the proliferation resistance aspects of nuclear energy systems are best considered beginning at the very outset of the design process. Only in this way can the designer identify and cost effectively incorporate intrinsic features that might be difficult to implement at some later stage. Also, just like safety, the process to implement proliferation resistance should be a dynamic

  15. Methodology assessment and recommendations for the Mars science laboratory launch safety analysis.

    SciTech Connect

    Sturgis, Beverly Rainwater; Metzinger, Kurt Evan; Powers, Dana Auburn; Atcitty, Christopher B.; Robinson, David B; Hewson, John C.; Bixler, Nathan E.; Dodson, Brian W.; Potter, Donald L.; Kelly, John E.; MacLean, Heather J.; Bergeron, Kenneth Donald (Sala & Associates); Bessette, Gregory Carl; Lipinski, Ronald J.

    2006-09-01

    thousands of possible event sequences and to build up a statistical representation of the releases for each accident case. A code to carry out this process will have to be developed or adapted from previous MMRTG missions. Finally, Level C translates the release (or ''source term'') information from Level B into public risk by applying models for atmospheric transport and the health consequences of exposure to the released plutonium dioxide. A number of candidate codes for this level of analysis are available. This report surveys the range of available codes and tools for each of these levels and makes recommendations for which choices are best for the MSL mission. It also identities areas where improvements to the codes are needed. In some cases a second tier of codes may be identified to provide supporting or clarifying insight about particular issues. The main focus of the methodology assessment is to identify a suite of computational tools that can produce a high quality SAR that can be successfully reviewed by external bodies (such as the Interagency Nuclear Safety Review Panel) on the schedule established by NASA and DOE.

  16. Safety assessment comparison methodology for toxic and radioactive wastes (SACO version 1.0)

    SciTech Connect

    Torres, C.; Simon, I.; Agueero, A.; Little, R.H.; Smith, G.M.

    1993-12-31

    As part of a research contract jointly funded by the Commission of the European Communities (CEC) and Empresa Nacional de Residuos Radiactivos S.A. (Enresa, Spain), the Instituto de Medioambiente of the CIEMAT Research Centre and Intera (UK) are developing and testing a general methodology (SACO) to assess the post-disposal environmental impact produced by waste disposal practices. The scope of the methodology includes toxic, radioactive and mixed hazardous wastes. The term toxic is interpreted broadly to include any kind of liquid or solid non-radioactive waste which could give rise to some detrimental environmental effects post-disposal. Radioactive wastes considered include the full range from low to high level solid wastes arising inside and outside the nuclear power industry. Mixed hazardous waste is taken to be waste presenting both radioactive and other toxic hazard potential. In this paper SACO version 1.0 methodology is presented and it is applied to the assessment of the impact of shallow and deep disposal of waste.

  17. Considering new methodologies in strategies for safety assessment of foods and food ingredients.

    PubMed

    Blaauboer, Bas J; Boobis, Alan R; Bradford, Bobbie; Cockburn, Andrew; Constable, Anne; Daneshian, Mardas; Edwards, Gareth; Garthoff, Jossie A; Jeffery, Brett; Krul, Cyrille; Schuermans, Jeroen

    2016-05-01

    Toxicology and safety assessment are changing and require new strategies for evaluating risk that are less depending on apical toxicity endpoints in animal models and relying more on knowledge of the mechanism of toxicity. This manuscript describes a number of developments that could contribute to this change and implement this in a stepwise roadmap that can be applied for the evaluation of food and food ingredients. The roadmap was evaluated in four case studies by using literature and existing data. This preliminary evaluation was shown to be useful. However, this experience should be extended by including examples where experimental work needs to be included. To further implement these new insights in toxicology and safety assessment for the area of food and food ingredients, the recommendation is that stakeholders take action in addressing gaps in our knowledge, e.g. with regard to the applicability of the roadmap for mixtures and food matrices. Further development of the threshold of toxicological concern is needed, as well as cooperation with other sectors where similar schemes are under development. Moreover, a more comprehensive evaluation of the roadmap, also including the identification of the need for in vitro experimental work is recommended. PMID:26939913

  18. A methodology for determining interactions in probabilistic safety assessment models by varying one parameter at a time.

    PubMed

    Borgonovo, Emanuele

    2010-03-01

    In risk analysis problems, the decision-making process is supported by the utilization of quantitative models. Assessing the relevance of interactions is an essential information in the interpretation of model results. By such knowledge, analysts and decisionmakers are able to understand whether risk is apportioned by individual factor contributions or by their joint action. However, models are oftentimes large, requiring a high number of input parameters, and complex, with individual model runs being time consuming. Computational complexity leads analysts to utilize one-parameter-at-a-time sensitivity methods, which prevent one from assessing interactions. In this work, we illustrate a methodology to quantify interactions in probabilistic safety assessment (PSA) models by varying one parameter at a time. The method is based on a property of the functional ANOVA decomposition of a finite change that allows to exactly determine the relevance of factors when considered individually or together with their interactions with all other factors. A set of test cases illustrates the technique. We apply the methodology to the analysis of the core damage frequency of the large loss of coolant accident of a nuclear reactor. Numerical results reveal the nonadditive model structure, allow to quantify the relevance of interactions, and to identify the direction of change (increase or decrease in risk) implied by individual factor variations and by their cooperation. PMID:20199656

  19. From technological acceptability to appropriation by users: methodological steps for device assessment in road safety.

    PubMed

    Bordel, Stéphanie; Somat, Alain; Barbeau, Hervé; Anceaux, Françoise; Greffeuille, Catherine; Menguy, Gaëlle; Pacaux, Marie-Pierre; Subirats, Peggy; Terrade, Florence; Gallenne, Marie-Line

    2014-06-01

    This article presents the methodology developed within the framework of the research project SARI (Automated Road Surveillance for Driver and Administrator Information). This methodology is based on the logic of action research. The article presents the different stages in the development of technological innovation addressing vehicle control loss when driving on a curve. The results observed in speed reduction illustrate that no matter how optimal an innovation may be technologically speaking, it is only as effective as it is acceptable from a user standpoint. This acceptability can only be obtained if the technology is developed by engineers in liaison with social science specialists. PMID:24508421

  20. Safety Assessment for Inertial Fusion Energy Power Plants: Methodology and Application to the Analysis of the HYLIFE-II and SOMBRERO Conceptual Designs

    NASA Astrophysics Data System (ADS)

    Reyes, S.; Latkowski, J. F.; Sanz, J.; Gomez del Rio, J.

    2001-06-01

    Although the safety and environmental (S & E) characteristics of fusion energy have long been emphasized, these benefits are not automatically achieved. To maximize the potential S & E attractiveness of the inertial fusion energy (IFE), analyses must be performed early in the designs so that lessons can be learned and intelligent decisions made. In this work we have introduced for the first time heat transfer and thermal-hydraulics calculations as part of a state-of-the-art set of codes and libraries in order to establish an updated methodology for IFE safety analysis. We have focused our efforts primarily on two IFE power plant conceptual designs: HYLIFE-II and SOMBRERO. To some degree, these designs represent the extremes in IFE power plant designs. Also, a preliminary safety assessment has been performed for a generic target fabrication facility producing various types of targets and using various production techniques. Although this study cannot address all issues and hazards posed by an IFE power plant, it advances our understanding of radiological safety of such facilities. This will enable better comparisons between IFE designs and competing technologies from the safety point of view.

  1. Environmental probabilistic quantitative assessment methodologies

    USGS Publications Warehouse

    Crovelli, R.A.

    1995-01-01

    In this paper, four petroleum resource assessment methodologies are presented as possible pollution assessment methodologies, even though petroleum as a resource is desirable, whereas pollution is undesirable. A methodology is defined in this paper to consist of a probability model and a probabilistic method, where the method is used to solve the model. The following four basic types of probability models are considered: 1) direct assessment, 2) accumulation size, 3) volumetric yield, and 4) reservoir engineering. Three of the four petroleum resource assessment methodologies were written as microcomputer systems, viz. TRIAGG for direct assessment, APRAS for accumulation size, and FASPU for reservoir engineering. A fourth microcomputer system termed PROBDIST supports the three assessment systems. The three assessment systems have different probability models but the same type of probabilistic method. The type of advantages of the analytic method are in computational speed and flexibility, making it ideal for a microcomputer. -from Author

  2. LNG Safety Assessment Evaluation Methods

    SciTech Connect

    Muna, Alice Baca; LaFleur, Angela Christine

    2015-05-01

    Sandia National Laboratories evaluated published safety assessment methods across a variety of industries including Liquefied Natural Gas (LNG), hydrogen, land and marine transportation, as well as the US Department of Defense (DOD). All the methods were evaluated for their potential applicability for use in the LNG railroad application. After reviewing the documents included in this report, as well as others not included because of repetition, the Department of Energy (DOE) Hydrogen Safety Plan Checklist is most suitable to be adapted to the LNG railroad application. This report was developed to survey industries related to rail transportation for methodologies and tools that can be used by the FRA to review and evaluate safety assessments submitted by the railroad industry as a part of their implementation plans for liquefied or compressed natural gas storage ( on-board or tender) and engine fueling delivery systems. The main sections of this report provide an overview of various methods found during this survey. In most cases, the reference document is quoted directly. The final section provides discussion and a recommendation for the most appropriate methodology that will allow efficient and consistent evaluations to be made. The DOE Hydrogen Safety Plan Checklist was then revised to adapt it as a methodology for the Federal Railroad Administration’s use in evaluating safety plans submitted by the railroad industry.

  3. Methodological innovations expand the safety pharmacology horizon.

    PubMed

    Pugsley, M K; Curtis, M J

    2012-09-01

    Almost uniquely in pharmacology, drug safety assessment is driven by the need for elaboration and validation of methods for detecting drug actions. This is the 9th consecutive year that the Journal of Pharmacological and Toxicological Methods (JPTM) has published themed issues arising from the annual meeting of the Safety Pharmacology Society (SPS). The SPS is now past its 10th year as a distinct (from pharmacology to toxicology) discipline that integrates safety pharmacologists from industry with those in academia and the various global regulatory authorities. The themes of the 2011 meeting were (i) the bridging of safety assessment of a new chemical entity (NCE) between all the parties involved, (ii) applied technologies and (iii) translation. This issue of JPTM reflects these themes. The content is informed by the regulatory guidance documents (S7A and S7B) that apply prior to first in human (FIH) studies, which emphasize the importance of seeking model validation. The manuscripts encompass a broad spectrum of safety pharmacology topics including application of state-of-the-art techniques for study conduct and data processing and evaluation. This includes some exciting novel integrated core battery study designs, refinements in hemodynamic assessment, arrhythmia analysis algorithms, and additionally an overview of safety immunopharmacology, and a brief survey discussing similarities and differences in business models that pharmaceutical companies employ in safety pharmacology, together with SPS recommendations on 'best practice' for the conduct of a non-clinical cardiovascular assessment of a NCE. PMID:22617368

  4. WATER QUALITY ASSESSMENT METHODOLOGY (WQAM)

    EPA Science Inventory

    The Water Quality Assessment Methodology (WQAM) is a screening procedure for toxic and conventional pollutants in surface and ground waters and is a collection of formulas, tables, and graphs that planners can use for preliminary assessment of surface and ground water quality in ...

  5. Uncertainty and sensitivity analysis within the post closure Performance and Safety Assessment of the French deep geological radwaste disposal: methodology, tool and examples of results

    NASA Astrophysics Data System (ADS)

    Pepin, G.

    2009-04-01

    Within the framework of the December 30, 1991 french act, Andra submitted to the French Parliament in December 2005 a report on the feasibility of a high-level and long-lived radwaste disposal in the Callovo-Oxfodien clay layer (Meuse/Haute-Marne site). Further to 2006 french act, Andra is now involved in licensing of the reversible disposal up to 2015, which requires a great scientific and technical knowledge. Studies are based on many years of research carried out in France, in particular in Andra's Meuse/Haute-Marne Underground Research Laboratory (MHM URL), and international programs on radwastes, engineered barriers and deep clay formations. Intensive programs on hydraulic, solute transfer and radionuclides behaviour (solubility, retention) were and are carried out on Callovo-Oxfordian argilites (undisturbed and damaged), concrete materials and swelling clay based material, in order to provide a sound database. All these data allowed to perform firstly a sound description of the expected phenomenological evolution of the repository and its geological environment (including release and migration of radionuclides) from operating period to post closure period up to one million years, secondly a sound post-closure performance and safety assessment covering the different waste types (ILLW, HLW). Various safety scenarii were defined to quantify radiological impacts and to evaluate performance of the components and safety functions in post closure using specific indicators (concentration, molar rate, water flux…). According to the RFS III2.f (french safety rule related to deep geological radwaste disposad), there is no risk analysis in post closure and assessments are performed using deterministic situations, models and values. To complete analysis, propagation of uncertainties from models and input data in Performance and Safey Assessment (PA/SA) models is done using both deterministic and multiparametric probabilistic approach, with two main objectives: (i) to

  6. Safety Auditing and Assessments

    NASA Technical Reports Server (NTRS)

    Goodin, James Ronald (Ronnie)

    2005-01-01

    Safety professionals typically do not engage in audits and independent assessments with the vigor as do our quality brethren. Taking advantage of industry and government experience conducting value added Independent Assessments or Audits benefits a safety program. Most other organizations simply call this process "internal audits." Sources of audit training are presented and compared. A relation of logic between audit techniques and mishap investigation is discussed. An example of an audit process is offered. Shortcomings and pitfalls of auditing are covered.

  7. Reactor safety assessment system

    SciTech Connect

    Sebo, D.E.; Bray, M.A.; King, M.A.

    1987-01-01

    The Reactor Safety Assessment System (RSAS) is an expert system under development for the United States Nuclear Regulatory Commission (USNRC). RSA is designed for use at the USNRC Operations Center in the event of a serious incident at a licensed nuclear power plant. RSAS is a situation assessment expert system which uses plant parametric data to generate conclusions for use by the NRC Reactor Safety Team. RSAS uses multiple rule bases and plant specific setpoint files to be applicable to all licensed nuclear power plants in the United States. RSAS currently covers several generic reactor categories and multiple plants within each category.

  8. Application of Bow-tie methodology to improve patient safety.

    PubMed

    Abdi, Zhaleh; Ravaghi, Hamid; Abbasi, Mohsen; Delgoshaei, Bahram; Esfandiari, Somayeh

    2016-05-01

    Purpose - The purpose of this paper is to apply Bow-tie methodology, a proactive risk assessment technique based on systemic approach, for prospective analysis of the risks threatening patient safety in intensive care unit (ICU). Design/methodology/approach - Bow-tie methodology was used to manage clinical risks threatening patient safety by a multidisciplinary team in the ICU. The Bow-tie analysis was conducted on incidents related to high-alert medications, ventilator associated pneumonia, catheter-related blood stream infection, urinary tract infection, and unwanted extubation. Findings - In total, 48 potential adverse events were analysed. The causal factors were identified and classified into relevant categories. The number and effectiveness of existing preventive and protective barriers were examined for each potential adverse event. The adverse events were evaluated according to the risk criteria and a set of interventions were proposed with the aim of improving the existing barriers or implementing new barriers. A number of recommendations were implemented in the ICU, while considering their feasibility. Originality/value - The application of Bow-tie methodology led to practical recommendations to eliminate or control the hazards identified. It also contributed to better understanding of hazard prevention and protection required for safe operations in clinical settings. PMID:27142951

  9. Human error risk management methodology for safety audit of a large railway organisation.

    PubMed

    Cacciabue, P C

    2005-11-01

    This paper considers the application of the human error risk management for engineering systems (HERMES) methodology for safety assessment studies. The application concerns the recurrent safety audits (RSA) of a large organisation in the domain of railway transportation systems. The objective of the study was the identification of the most relevant areas of intervention for improving safety and reliability of the service. The methodology has been applied to the whole organisation and its working processes. Specific attention was paid to train drivers. A number of critical indicators of safety and recurrent safety audit matrices were identified, which enabled the assessment of the safety level of the organisation and the generation of safety recommendations. The application of HERMES to this case study shows that the methodology is applicable in practice and can give valuable and significant results. PMID:16122693

  10. Simulation Enabled Safeguards Assessment Methodology

    SciTech Connect

    Robert Bean; Trond Bjornard; Thomas Larson

    2007-09-01

    It is expected that nuclear energy will be a significant component of future supplies. New facilities, operating under a strengthened international nonproliferation regime will be needed. There is good reason to believe virtual engineering applied to the facility design, as well as to the safeguards system design will reduce total project cost and improve efficiency in the design cycle. Simulation Enabled Safeguards Assessment MEthodology (SESAME) has been developed as a software package to provide this capability for nuclear reprocessing facilities. The software architecture is specifically designed for distributed computing, collaborative design efforts, and modular construction to allow step improvements in functionality. Drag and drop wireframe construction allows the user to select the desired components from a component warehouse, render the system for 3D visualization, and, linked to a set of physics libraries and/or computational codes, conduct process evaluations of the system they have designed.

  11. [Agricultural biotechnology safety assessment].

    PubMed

    McClain, Scott; Jones, Wendelyn; He, Xiaoyun; Ladics, Gregory; Bartholomaeus, Andrew; Raybould, Alan; Lutter, Petra; Xu, Haibin; Wang, Xue

    2015-01-01

    Genetically modified (GM) crops were first introduced to farmers in 1995 with the intent to provide better crop yield and meet the increasing demand for food and feed. GM crops have evolved to include a thorough safety evaluation for their use in human food and animal feed. Safety considerations begin at the level of DNA whereby the inserted GM DNA is evaluated for its content, position and stability once placed into the crop genome. The safety of the proteins coded by the inserted DNA and potential effects on the crop are considered, and the purpose is to ensure that the transgenic novel proteins are safe from a toxicity, allergy, and environmental perspective. In addition, the grain that provides the processed food or animal feed is also tested to evaluate its nutritional content and identify unintended effects to the plant composition when warranted. To provide a platform for the safety assessment, the GM crop is compared to non-GM comparators in what is typically referred to as composition equivalence testing. New technologies, such as mass spectrometry and well-designed antibody-based methods, allow better analytical measurements of crop composition, including endogenous allergens. Many of the analytical methods and their intended uses are based on regulatory guidance documents, some of which are outlined in globally recognized documents such as Codex Alimentarius. In certain cases, animal models are recommended by some regulatory agencies in specific countries, but there is typically no hypothesis or justification of their use in testing the safety of GM crops. The quality and standardization of testing methods can be supported, in some cases, by employing good laboratory practices (GLP) and is recognized in China as important to ensure quality data. Although the number of recommended, in some cases, required methods for safety testing are increasing in some regulatory agencies, it should be noted that GM crops registered to date have been shown to be

  12. HSE's safety assessment principles for criticality safety.

    PubMed

    Simister, D N; Finnerty, M D; Warburton, S J; Thomas, E A; Macphail, M R

    2008-06-01

    The Health and Safety Executive (HSE) published its revised Safety Assessment Principles for Nuclear Facilities (SAPs) in December 2006. The SAPs are primarily intended for use by HSE's inspectors when judging the adequacy of safety cases for nuclear facilities. The revised SAPs relate to all aspects of safety in nuclear facilities including the technical discipline of criticality safety. The purpose of this paper is to set out for the benefit of a wider audience some of the thinking behind the final published words and to provide an insight into the development of UK regulatory guidance. The paper notes that it is HSE's intention that the Safety Assessment Principles should be viewed as a reflection of good practice in the context of interpreting primary legislation such as the requirements under site licence conditions for arrangements for producing an adequate safety case and for producing a suitable and sufficient risk assessment under the Ionising Radiations Regulations 1999 (SI1999/3232 www.opsi.gov.uk/si/si1999/uksi_19993232_en.pdf). PMID:18495990

  13. Sounding rocket and balloon flight safety philosophy and methodologies

    NASA Technical Reports Server (NTRS)

    Beyma, R. J.

    1986-01-01

    NASA's sounding rocket and balloon goal is to successfully and safely perform scientific research. This is reflected in the design, planning, and conduct of sounding rocket and balloon operations. The purpose of this paper is to acquaint the sounding rocket and balloon scientific community with flight safety philosophy and methodologies, and how range safety affects their programs. This paper presents the flight safety philosophy for protecting the public against the risk created by the conduct of sounding rocket and balloon operations. The flight safety criteria used to implement this philosophy are defined and the methodologies used to calculate mission risk are described.

  14. Methodological assessment of HCC literature

    PubMed Central

    Daniele, G.; Costa, N.; Lorusso, V.; Costa-Maia, J.; Pache, I.; Pirisi, M.

    2013-01-01

    Despite the fact that the hepatocellular carcinoma (HCC) represents a major health problem, very few interventions are available for this disease, and only sorafenib is approved for the treatment of advanced disease. Of note, only very few interventions have been thoroughly evaluated over time for HCC patients compared with several hundreds in other, equally highly lethal, tumours. Additionally, clinical trials in HCC have often been questioned for poor design and methodological issues. As a consequence, a gap between what is measured in clinical trials and what clinicians have to face in daily practice often occurs. As a result of this scenario, even the most recent guidelines for treatment of HCC patients use low strength evidence to make recommendations. In this review, we will discuss some of the potential methodological issues hindering a rational development of new treatments for HCC patients. PMID:23715943

  15. IMPORTANCE OF SAFETY CULTURE ASSESSMENT

    SciTech Connect

    Spitalnik, J.

    2004-10-06

    Safety Management has lately been considered by some Nuclear Regulatory agencies as the tool on which to concentrate their efforts to implement modern regulation structures, because Safety Culture was said to be difficult to monitor. However, Safety Culture can be assessed and monitored even if it is problematical to make Safety Culture the object of regulation. This paper stresses the feasibility and importance of Safety Culture Assessment based on self-assessment applications performed in several nuclear organizations in Latin America. Reasons and ownership for assessing Safety Culture are discussed, and relevant aspects considered for setting up and programming such an assessment are shown. Basic principles that were taken into account, as well as financial and human resources used in actual self-assessments are reviewed, including the importance of adequate statistical analyses and the necessity of proper feed-back of results. The setting up of action plans to enhance Safety Culture is the final step of the assessment program that once implemented will enable to establish a Safety Culture monitoring process within the organization.

  16. HANFORD SAFETY ANALYSIS & RISK ASSESSMENT HANDBOOK (SARAH)

    SciTech Connect

    EVANS, C B

    2004-12-21

    The purpose of the Hanford Safety Analysis and Risk Assessment Handbook (SARAH) is to support the development of safety basis documentation for Hazard Category 2 and 3 (HC-2 and 3) U.S. Department of Energy (DOE) nuclear facilities to meet the requirements of 10 CFR 830, ''Nuclear Safety Management''. Subpart B, ''Safety Basis Requirements.'' Consistent with DOE-STD-3009-94, Change Notice 2, ''Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Documented Safety Analyses'' (STD-3009), and DOE-STD-3011-2002, ''Guidance for Preparation of Basis for Interim Operation (BIO) Documents'' (STD-3011), the Hanford SARAH describes methodology for performing a safety analysis leading to development of a Documented Safety Analysis (DSA) and derivation of Technical Safety Requirements (TSR), and provides the information necessary to ensure a consistently rigorous approach that meets DOE expectations. The DSA and TSR documents, together with the DOE-issued Safety Evaluation Report (SER), are the basic components of facility safety basis documentation. For HC-2 or 3 nuclear facilities in long-term surveillance and maintenance (S&M), for decommissioning activities, where source term has been eliminated to the point that only low-level, residual fixed contamination is present, or for environmental remediation activities outside of a facility structure, DOE-STD-1120-98, ''Integration of Environment, Safety, and Health into Facility Disposition Activities'' (STD-1120), may serve as the basis for the DSA. HC-2 and 3 environmental remediation sites also are subject to the hazard analysis methodologies of this standard.

  17. EXPOSURE ASSESSMENT METHODOLOGIES FOR HUMANS AND ECOSYSTEMS

    EPA Science Inventory

    Scientists and risk assessment experts are developing approaches to estimate exposure of human populations and ecosystems to environmental contaminants. cological scientists are exploring methodologies for estimating the exposure of ecosystems and their subdivisions to environmen...

  18. Space station data management system assessment methodology

    NASA Technical Reports Server (NTRS)

    Jones, W. R.; Bahrs, D. L.

    1986-01-01

    A computer-aided modeling tool and methodology was developed and is currently being used to assess candidate designs for the Space Station Data Management System (DMS). The DMS will be a complex distributed computer system including processors, storage devices, local area networks, and software that will support all processing functions on board the Space Station. The methodology produces assessments of the performance, reliability, cost, and physical attributes of the candidate designs. This paper describes the architecture and design of the modeling tool and presents the modeling methodology.

  19. The strainer blockage assessment methodology used

    SciTech Connect

    Zigler, G.L.; Rao, D.V.

    1996-03-01

    On July 28, 1992 a spurious opening of a safety valve at Barseback Unit 2 in Sweden resulted in clogging of the Containment Vessel Spray System strainers in less than one hour. Instances of ECCS strainer clogging have occurred in U.S. BWRs. Given these precursors the USNRC staff initiated analyses to estimate the potential for loss of NPSH of the ECCS pumps in BWRs due to clogging of suction strainers by a combination of fibrous and particulate material. The BLOCKAGE code was developed in support of NUREG/CR-6224, a probabilistic scoping analysis of a BWR/4 with a Mark 1 containment. This paper addresses the key elements of the methodology used in the BLOCKAGE code to assess head loss across ECCS strainers. The debris generation model, the debris drywell transport, and the suppression pool models are discussed briefly. NUREG/CR-6224 provides in-depth discussions of the models used in BLOCKAGE. Additionally, user interface features of BLOCKAGE are discussed.

  20. Using Risk Assessment Methodologies to Meet Management Objectives

    NASA Technical Reports Server (NTRS)

    DeMott, D. L.

    2015-01-01

    Current decision making involves numerous possible combinations of technology elements, safety and health issues, operational aspects and process considerations to satisfy program goals. Identifying potential risk considerations as part of the management decision making process provides additional tools to make more informed management decision. Adapting and using risk assessment methodologies can generate new perspectives on various risk and safety concerns that are not immediately apparent. Safety and operational risks can be identified and final decisions can balance these considerations with cost and schedule risks. Additional assessments can also show likelihood of event occurrence and event consequence to provide a more informed basis for decision making, as well as cost effective mitigation strategies. Methodologies available to perform Risk Assessments range from qualitative identification of risk potential, to detailed assessments where quantitative probabilities are calculated. Methodology used should be based on factors that include: 1) type of industry and industry standards, 2) tasks, tools, and environment 3) type and availability of data and 4) industry views and requirements regarding risk & reliability. Risk Assessments are a tool for decision makers to understand potential consequences and be in a position to reduce, mitigate or eliminate costly mistakes or catastrophic failures.

  1. Safety Assessment of Probiotics

    NASA Astrophysics Data System (ADS)

    Lahtinen, Sampo J.; Boyle, Robert J.; Margolles, Abelardo; Frias, Rafael; Gueimonde, Miguel

    Viable microbes have been a natural part of human diet throughout the history of mankind. Today, different fermented foods and other foods containing live microbes are consumed around the world, including industrialized countries, where the diet has become increasingly sterile during the last decades. By definition, probiotics are viable microbes with documented beneficial effects on host health. Probiotics have an excellent safety record, both in humans and in animals. Despite the wide and continuously increasing consumption of probiotics, adverse events related to probiotic use are extremely rare. Many popular probiotic strains such as lactobacilli and bifidobacteria can be considered as components of normal healthy intestinal microbiota, and thus are not thought to pose a risk for the host health - in contrast, beneficial effects on health are commonly reported. Nevertheless, the safety of probiotics is an important issue, in particular in the case of new potential probiotics which do not have a long history of safe use, and of probiotics belonging to species for which general assumption of safety cannot be made. Furthermore, safety of probiotics in high-risk populations such as critically ill patients and immunocompromized subjects deserves particular attention, as virtually all reported cases of bacteremia and fungemia associated with probiotic use, involve subjects with underlying diseases, compromised immune system or compromised intestinal integrity.

  2. Topaz II preliminary safety assessment

    SciTech Connect

    Marshall, A.C. ); Standley, V. ); Voss, S.S. ); Haskin, E. )

    1993-01-10

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz II space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safety assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the U.S. with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  3. Training effectiveness assessment: Methodological problems and issues

    NASA Technical Reports Server (NTRS)

    Cross, Kenneth D.

    1992-01-01

    The U.S. military uses a large number of simulators to train and sustain the flying skills of helicopter pilots. Despite the enormous resources required to purchase, maintain, and use those simulators, little effort has been expended in assessing their training effectiveness. One reason for this is the lack of an evaluation methodology that yields comprehensive and valid data at a practical cost. Some of these methodological problems and issues that arise in assessing simulator training effectiveness, as well as problems with the classical transfer-of-learning paradigm were discussed.

  4. Topaz II preliminary safety assessment

    SciTech Connect

    Marshall, A.C. ); Standley, V. ); Voss, S.S. ); Haskin, E. . Dept. of Chemical and Nuclear Engineering)

    1992-01-01

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz 11 space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safely assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the US with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  5. Gaseous-fuel safety assessment. Status report

    SciTech Connect

    Krupka, M.C.; Edeskuty, F.J.; Bartlit, J.R.; Williamson, K.D. Jr.

    1982-01-01

    The Los Alamos National Laboratory, in support of studies sponsored by the Office of Vehicle and Engine Research and Development in the US Department of Energy, has undertaken a safety assessment of selected gaseous fuels for use in light automotive transportation. The purpose is to put into perspective the hazards of these fuels relative to present day fuels and delineated criteria for their safe handling. Fuels include compressed and liquified natural gas (CNG and LNG), liquefied petroleum gas (LPG), and for reference gasoline and diesel. This paper is a program status report. To date, physicochemical property data and general petroleum and transportation information were compiled; basic hazards defined; alternative fuels were safety-ranked based on technical properties alone; safety data and vehicle accident statistics reviewed; and accident scenarios selected for further analysis. Methodology for such analysis is presently under consideration.

  6. Safety assessment of drug residues

    SciTech Connect

    Jackson, B.A.

    1980-05-15

    The safety assessment of drug residues is part of the process for defining the conditions for the safe use of drugs in food-producing animals. The information needed to assess the safety of drug residues is provided by chemical and toxicity tests. Toxicity tests are conducted to identify the type of effect produced and to determine the exposure concentrations that would be expected not to produce the effect. These tests include acute, subacute, and chronic toxicity tests, as well as reproduction studies and other special tests. The results are used to find an acceptable daily intake for drug residues that can be used to set a tolerance.

  7. Safety evaluation methodology for advanced coal extraction systems

    NASA Technical Reports Server (NTRS)

    Zimmerman, W. F.

    1981-01-01

    Qualitative and quantitative evaluation methods for coal extraction systems were developed. The analysis examines the soundness of the design, whether or not the major hazards have been eliminated or reduced, and how the reduction would be accomplished. The quantitative methodology establishes the approximate impact of hazards on injury levels. The results are weighted by peculiar geological elements, specialized safety training, peculiar mine environmental aspects, and reductions in labor force. The outcome is compared with injury level requirements based on similar, safer industries to get a measure of the new system's success in reducing injuries. This approach provides a more detailed and comprehensive analysis of hazards and their effects than existing safety analyses.

  8. Critical infrastructure systems of systems assessment methodology.

    SciTech Connect

    Sholander, Peter E.; Darby, John L.; Phelan, James M.; Smith, Bryan; Wyss, Gregory Dane; Walter, Andrew; Varnado, G. Bruce; Depoy, Jennifer Mae

    2006-10-01

    Assessing the risk of malevolent attacks against large-scale critical infrastructures requires modifications to existing methodologies that separately consider physical security and cyber security. This research has developed a risk assessment methodology that explicitly accounts for both physical and cyber security, while preserving the traditional security paradigm of detect, delay, and respond. This methodology also accounts for the condition that a facility may be able to recover from or mitigate the impact of a successful attack before serious consequences occur. The methodology uses evidence-based techniques (which are a generalization of probability theory) to evaluate the security posture of the cyber protection systems. Cyber threats are compared against cyber security posture using a category-based approach nested within a path-based analysis to determine the most vulnerable cyber attack path. The methodology summarizes the impact of a blended cyber/physical adversary attack in a conditional risk estimate where the consequence term is scaled by a ''willingness to pay'' avoidance approach.

  9. An object-oriented approach to risk and reliability analysis : methodology and aviation safety applications.

    SciTech Connect

    Dandini, Vincent John; Duran, Felicia Angelica; Wyss, Gregory Dane

    2003-09-01

    This article describes how features of event tree analysis and Monte Carlo-based discrete event simulation can be combined with concepts from object-oriented analysis to develop a new risk assessment methodology, with some of the best features of each. The resultant object-based event scenario tree (OBEST) methodology enables an analyst to rapidly construct realistic models for scenarios for which an a priori discovery of event ordering is either cumbersome or impossible. Each scenario produced by OBEST is automatically associated with a likelihood estimate because probabilistic branching is integral to the object model definition. The OBEST methodology is then applied to an aviation safety problem that considers mechanisms by which an aircraft might become involved in a runway incursion incident. The resulting OBEST model demonstrates how a close link between human reliability analysis and probabilistic risk assessment methods can provide important insights into aviation safety phenomenology.

  10. Vending machine assessment methodology. A systematic review.

    PubMed

    Matthews, Melissa A; Horacek, Tanya M

    2015-07-01

    The nutritional quality of food and beverage products sold in vending machines has been implicated as a contributing factor to the development of an obesogenic food environment. How comprehensive, reliable, and valid are the current assessment tools for vending machines to support or refute these claims? A systematic review was conducted to summarize, compare, and evaluate the current methodologies and available tools for vending machine assessment. A total of 24 relevant research studies published between 1981 and 2013 met inclusion criteria for this review. The methodological variables reviewed in this study include assessment tool type, study location, machine accessibility, product availability, healthfulness criteria, portion size, price, product promotion, and quality of scientific practice. There were wide variations in the depth of the assessment methodologies and product healthfulness criteria utilized among the reviewed studies. Of the reviewed studies, 39% evaluated machine accessibility, 91% evaluated product availability, 96% established healthfulness criteria, 70% evaluated portion size, 48% evaluated price, 52% evaluated product promotion, and 22% evaluated the quality of scientific practice. Of all reviewed articles, 87% reached conclusions that provided insight into the healthfulness of vended products and/or vending environment. Product healthfulness criteria and complexity for snack and beverage products was also found to be variable between the reviewed studies. These findings make it difficult to compare results between studies. A universal, valid, and reliable vending machine assessment tool that is comprehensive yet user-friendly is recommended. PMID:25772195

  11. Process waste assessment methodology for mechanical departments

    SciTech Connect

    Hedrick, R.B.

    1992-12-01

    Process waste assessments (PWAS) were performed for three pilot processes to develop methodology for performing PWAs for all the various processes used throughout the mechanical departments. A material balance and process flow diagram identifying the raw materials utilized in the process and the quantity and types of materials entering the waste streams from the process is defined for each PWA. The data and information are used to determine potential options'' for eliminating hazardous materials or minimizing wastes generated.

  12. Safety evaluation methodology for advanced coal extraction systems

    SciTech Connect

    Zimmerman, W.F.

    1981-07-15

    To be acceptable to the coal industry, an advanced extraction system must provide a significant improvement over conventional systems in cost, safety, environmental impact, and conservation of unmined coal. Qualitative and quantitative evaluation methodologies were developed to assist the designer in determining if a proposed extraction design will be safer than existing systems. The qualitative analysis is a process which tests the new system against regulations and hazards of existing similar systems. The analysis examines the soundness of the design, whether or not the major hazards have been eliminated or reduced, and how the reduction would be accomplished. The quantitative methodology provides the designer with a means of establishing the approximate impact of hazards on injury levels. The results are further weighted by peculiar geological elements, specialized safety training, peculiar mine environmental aspects, and reductions in labor force. The outcome is compared with injury level requirements based on similar, safer industries to get a measure of the new system's success in reducing injuries. This approach provides a more detailed and comprehensive analysis of hazards and their effects than existing safety analyses.

  13. Flammability Assessment Methodology Program Phase I: Final Report

    SciTech Connect

    C. A. Loehr; S. M. Djordjevic; K. J. Liekhus; M. J. Connolly

    1997-09-01

    The Flammability Assessment Methodology Program (FAMP) was established to investigate the flammability of gas mixtures found in transuranic (TRU) waste containers. The FAMP results provide a basis for increasing the permissible concentrations of flammable volatile organic compounds (VOCs) in TRU waste containers. The FAMP results will be used to modify the ''Safety Analysis Report for the TRUPACT-II Shipping Package'' (TRUPACT-II SARP) upon acceptance of the methodology by the Nuclear Regulatory Commission. Implementation of the methodology would substantially increase the number of drums that can be shipped to the Waste Isolation Pilot Plant (WIPP) without repackaging or treatment. Central to the program was experimental testing and modeling to predict the gas mixture lower explosive limit (MLEL) of gases observed in TRU waste containers. The experimental data supported selection of an MLEL model that was used in constructing screening limits for flammable VOC and flammable gas concentrations. The MLEL values predicted by the model for individual drums will be utilized to assess flammability for drums that do not meet the screening criteria. Finally, the predicted MLEL values will be used to derive acceptable gas generation rates, decay heat limits, and aspiration time requirements for drums that do not pass the screening limits. The results of the program demonstrate that an increased number of waste containers can be shipped to WIPP within the flammability safety envelope established in the TRUPACT-II SARP.

  14. Safety assessment of Cordyceps guangdongensis.

    PubMed

    Yan, Wen-juan; Li, Tai-Hui; Lin, Qun-ying; Song, Bin; Jiang, Zi-de

    2010-11-01

    Cordyceps guangdongensis as a kind of fungus, has been discovered and cultivated successfully in recent years. However, its safety assessments have not been studied. In this report, a serial of tests for toxicological safety assessments were depicted in details. These tests included bacterial reverse mutation (Ames) study, bone marrow cell micronucleus test in mice, sperm aberration test in mice, teratogenicaction test in rats, acute toxicity test and 13-week oral toxicity study in rats. After a profound analysis of these tests, it clearly demonstrated that C. guangdongensis did not have any mutagenic, clastogenic nor genotoxic effects; the oral LD50 of the biomass in rats was greater than 15 g/kg body weight; the no-observed adverse-effect-levels (NOAEL) was 5.33 g/kg body weight according to the 13-week oral toxicity analysis. Therefore, a conclusion can be drawn that C. guangdongensis is considered safe for long term consumption. PMID:20692314

  15. Advances in assessing ingredient safety.

    PubMed

    Dourson, Michael L; York, Raymond G

    2016-08-01

    The safety of food ingredients will be assessed in the 21st century by mixture of traditional methods, such as the "safe" dose concept, which is thought to be an accurate but imprecise estimation of dose below the population threshold for adverse effect, and contemporary methods, such as the Benchmark Dose (BMD), Chemical Specific Adjustment Factors (CSAF), physiologically-based pharmacokinetic models, and biologically-informed dose response modeling. New research on the horizon related to toxicology 21 may also improve these risk assessment methods, or suggest new ones. These traditional, contemporary and new methods and research will be briefly described. PMID:27427210

  16. Salt vulnerability assessment methodology for urban streams

    NASA Astrophysics Data System (ADS)

    Betts, A. R.; Gharabaghi, B.; McBean, E. A.

    2014-09-01

    De-icing agents such as road salts while used for winter road maintenance can cause negative effects on urban stream water quality and drinking water supplies. A new methodology using readily available spatial data to identify Salt Vulnerable Areas (SVAs) for urban streams is used to prioritize implementation of best management practices. The methodology calculates the probable chloride concentration statistics at specified points in the urban stream network and compares the results with known aquatic species exposure tolerance limits to characterize the vulnerability scores. The approach prioritizes implementation of best management practices to areas identified as vulnerable to road salt. The vulnerability assessment is performed on seven sites in four watersheds in the Greater Toronto Area and validated using the Hanlon Creek watershed in Guelph. The mean annual in-stream chloride concentration equation uses readily available spatial data - with province-wide coverage - that can be easily used in any urban watershed.

  17. Using Risk Assessment Methodologies to Meet Management Objectives

    NASA Technical Reports Server (NTRS)

    DeMott, D. L.

    2015-01-01

    Corporate and program objectives focus on desired performance and results. ?Management decisions that affect how to meet these objectives now involve a complex mix of: technology, safety issues, operations, process considerations, employee considerations, regulatory requirements, financial concerns and legal issues. ?Risk Assessments are a tool for decision makers to understand potential consequences and be in a position to reduce, mitigate or eliminate costly mistakes or catastrophic failures. Using a risk assessment methodology is only a starting point. ?A risk assessment program provides management with important input in the decision making process. ?A pro-active organization looks to the future to avoid problems, a reactive organization can be blindsided by risks that could have been avoided. ?You get out what you put in, how useful your program is will be up to the individual organization.

  18. Safety-related operator actions: methodology for developing criteria

    SciTech Connect

    Kozinsky, E.J.; Gray, L.H.; Beare, A.N.; Barks, D.B.; Gomer, F.E.

    1984-03-01

    This report presents a methodology for developing criteria for design evaluation of safety-related actions by nuclear power plant reactor operators, and identifies a supporting data base. It is the eleventh and final NUREG/CR Report on the Safety-Related Operator Actions Program, conducted by Oak Ridge National Laboratory for the US Nuclear Regulatory Commission. The operator performance data were developed from training simulator experiments involving operator responses to simulated scenarios of plant disturbances; from field data on events with similar scenarios; and from task analytic data. A conceptual model to integrate the data was developed and a computer simulation of the model was run, using the SAINT modeling language. Proposed is a quantitative predictive model of operator performance, the Operator Personnel Performance Simulation (OPPS) Model, driven by task requirements, information presentation, and system dynamics. The model output, a probability distribution of predicted time to correctly complete safety-related operator actions, provides data for objective evaluation of quantitative design criteria.

  19. Methodology for calculating guideline concentrations for safety shot sites

    SciTech Connect

    1997-06-01

    Residual plutonium (Pu), with trace quantities of depleted uranium (DU) or weapons grade uranium (WU), exists in surficial soils at the Nevada Test Site (NTS), Nellis Air Force Range (NAFR), and the Tonopah Test Range (TTR) as the result of the above-ground testing of nuclear weapons and special experiments involving the detonation of plutonium-bearing devices. The special experiments (referred to as safety shots) involving plutonium-bearing devices were conducted to study the behavior of Pu as it was being explosively compressed; ensure that the accidental detonation of the chemical explosive in a production weapon would not result in criticality; evaluate the ability of personnel to manage large-scale Pu dispersal accidents; and develop criteria for transportation and storage of nuclear weapons. These sites do not pose a health threat to either workers or the general public because they are under active institutional control. The DOE is committed to remediating the safety shot sites so that radiation exposure to the public, both now and in the future, will be maintained within the established limits and be as low as reasonably achievable. Remediation requires calculation of a guideline concentration for the Pu, U, and their decay products that are present in the surface soil. This document presents the methodology for calculating guideline concentrations of weapons grade plutonium, weapons grade uranium, and depleted uranium in surface soils at the safety shot sites. Emphasis is placed on obtaining site-specific data for use in calculating dose to potential residents from the residual soil contamination.

  20. Model-based safety assessments

    SciTech Connect

    Carlson, D.D.; Jones, T.R.

    1998-04-01

    Sandia National Laboratories performs systems analysis of high risk, high consequence systems. In particular, Sandia is responsible for the engineering of nuclear weapons, exclusive of the explosive physics package. In meeting this responsibility, Sandia has developed fundamental approaches to safety and a process for evaluating safety based on modeling and simulation. These approaches provide confidence in the safety of our nuclear weapons. Similar concepts may be applied to improve the safety of other high consequence systems.

  1. ASSESSMENT OF SEISMIC ANALYSIS METHODOLOGIES FOR DEEPLY EMBEDDED NPP STRUCTURES.

    SciTech Connect

    XU, J.; MILLER, C.; COSTANTINO, C.; HOFMAYER, C.; GRAVES, H. .

    2005-07-01

    Several of the new generation nuclear power plant designs have structural configurations which are proposed to be deeply embedded. Since current seismic analysis methodologies have been applied to shallow embedded structures (e.g., ASCE 4 suggest that simple formulations may be used to model embedment effect when the depth of embedment is less than 30% of its foundation radius), the US Nuclear Regulatory Commission is sponsoring a program at the Brookhaven National Laboratory with the objective of investigating the extent to which procedures acceptable for shallow embedment depths are adequate for larger embedment depths. This paper presents the results of a study comparing the response spectra obtained from two of the more popular analysis methods for structural configurations varying from shallow embedment to complete embedment. A typical safety related structure embedded in a soil profile representative of a typical nuclear power plant site was utilized in the study and the depths of burial (DOB) considered range from 25-100% the height of the structure. Included in the paper are: (1) the description of a simplified analysis and a detailed approach for the SSI analyses of a structure with various DOB, (2) the comparison of the analysis results for the different DOBs between the two methods, and (3) the performance assessment of the analysis methodologies for SSI analyses of deeply embedded structures. The resulting assessment from this study has indicated that simplified methods may be capable of capturing the seismic response for much deeper embedded structures than would be normally allowed by the standard practice.

  2. A risk assessment methodology using intuitionistic fuzzy set in FMEA

    NASA Astrophysics Data System (ADS)

    Chang, Kuei-Hu; Cheng, Ching-Hsue

    2010-12-01

    Most current risk assessment methods use the risk priority number (RPN) value to evaluate the risk of failure. However, conventional RPN methodology has been criticised as having five main shortcomings as follows: (1) the assumption that the RPN elements are equally weighted leads to over simplification; (2) the RPN scale itself has some non-intuitive statistical properties; (3) the RPN elements have many duplicate numbers; (4) the RPN is derived from only three factors mainly in terms of safety; and (5) the conventional RPN method has not considered indirect relations between components. To address the above issues, an efficient and comprehensive algorithm to evaluate the risk of failure is needed. This article proposes an innovative approach, which integrates the intuitionistic fuzzy set (IFS) and the decision-making trial and evaluation laboratory (DEMATEL) approach on risk assessment. The proposed approach resolves some of the shortcomings of the conventional RPN method. A case study, which assesses the risk of 0.15 µm DRAM etching process, is used to demonstrate the effectiveness of the proposed approach. Finally, the result of the proposed method is compared with the listing approaches of risk assessment methods.

  3. Quantifying reactor safety margins: Application of CSAU (Code Scalability, Applicability and Uncertainty) methodology to LBLOCA: Part 3, Assessment and ranging of parameters for the uncertainty analysis of LBLOCA codes

    SciTech Connect

    Wulff, W.; Boyack, B.E.; Duffey, R.B.; Griffith, P.; Katsma, K.R.; Lellouche, G.S.; Levy, S.; Rohatgi, U.S.; Wilson, G.E.; Zuber, N.

    1988-01-01

    Comparisons of results from TRAC-PF1/MOD1 code calculations with measurements from Separate Effects Tests, and published experimental data for modeling parameters have been used to determine the uncertainty ranges of code input and modeling parameters which dominate the uncertainty in predicting the Peak Clad Temperature for a postulated Large Break Loss of Coolant Accident (LBLOCA) in a four-loop Westinghouse Pressurized Water Reactor. The uncertainty ranges are used for a detailed statistical analysis to calculate the probability distribution function for the TRAC code-predicted Peak Clad Temperature, as is described in an attendant paper. Measurements from Separate Effects Tests and Integral Effects Tests have been compared with results from corresponding TRAC-PF1/MOD1 code calculations to determine globally the total uncertainty in predicting the Peak Clad Temperature for LBLOCAs. This determination is in support of the detailed statistical analysis mentioned above. The analyses presented here account for uncertainties in input parameters, in modeling and scaling, in computing and in measurements. The analyses are an important part of the work needed to implement the Code Scalability, Applicability and Uncertainty (CSAU) methodology. CSAU is needed to determine the suitability of a computer code for reactor safety analyses and the uncertainty in computer predictions. The results presented here are used to estimate the safety margin of a particular nuclear reactor power plant for a postulated accident. 25 refs., 10 figs., 11 tabs.

  4. Flightdeck Automation Problems (FLAP) Model for Safety Technology Portfolio Assessment

    NASA Technical Reports Server (NTRS)

    Ancel, Ersin; Shih, Ann T.

    2014-01-01

    NASA's Aviation Safety Program (AvSP) develops and advances methodologies and technologies to improve air transportation safety. The Safety Analysis and Integration Team (SAIT) conducts a safety technology portfolio assessment (PA) to analyze the program content, to examine the benefits and risks of products with respect to program goals, and to support programmatic decision making. The PA process includes systematic identification of current and future safety risks as well as tracking several quantitative and qualitative metrics to ensure the program goals are addressing prominent safety risks accurately and effectively. One of the metrics within the PA process involves using quantitative aviation safety models to gauge the impact of the safety products. This paper demonstrates the role of aviation safety modeling by providing model outputs and evaluating a sample of portfolio elements using the Flightdeck Automation Problems (FLAP) model. The model enables not only ranking of the quantitative relative risk reduction impact of all portfolio elements, but also highlighting the areas with high potential impact via sensitivity and gap analyses in support of the program office. Although the model outputs are preliminary and products are notional, the process shown in this paper is essential to a comprehensive PA of NASA's safety products in the current program and future programs/projects.

  5. Safety assessment of the tritium recovery system

    SciTech Connect

    Not Available

    1994-09-01

    This Safety Assessment (SA) contains descriptions and evaluations of the environmental, health, and safety issues associated with the Tritium Recovery System (TRS) at the Pinellas Plant. It provides: 1. site and facility descriptions, 2. an overall description of the TRS and its operations, 3. an evaluation of the hazards associated with TRS operations, 4. descriptions and analyses of the adequacy of measures taken to eliminate, control, or mitigate identified hazards, and 5. assessment of potential accidents and their associated risks. This SA contains the results of safety evaluations of TRS operations, equipment, and supplied systems. The evaluations include, as appropriate, preliminary hazards listings, qualitative risk assessments, and quantitative risk assessments.

  6. RADIOLOGICAL RISK ASSESSMENT METHODOLOGY DEVELOPMENT/IMPROVEMENTS

    EPA Science Inventory

    The office is developing improved methodologies and guidance for evaluating human health risks associated with exposure to environmental radiological contaminants. These activities involve coordination with numerous federal agencies and the development and communication of vari...

  7. A Common Methodology for Safety and Reliability Analysis for Space Reactor Missions

    NASA Astrophysics Data System (ADS)

    Frank, Michael V.

    2006-01-01

    The thesis of this paper is that the methodology of probabilistic risk management (PRM) has the capability to integrate both safety and reliability analyses for space nuclear missions. Practiced within a decision analysis framework, the concept of risk and the overall methodology of PRM are not dependent on whether the outcome affects mission success or mission safety. This paper presents the methodology by means of simplified examples.

  8. A Common Methodology for Safety and Reliability Analysis for Space Reactor Missions

    SciTech Connect

    Frank, Michael V.

    2006-01-20

    The thesis of this paper is that the methodology of probabilistic risk management (PRM) has the capability to integrate both safety and reliability analyses for space nuclear missions. Practiced within a decision analysis framework, the concept of risk and the overall methodology of PRM are not dependent on whether the outcome affects mission success or mission safety. This paper presents the methodology by means of simplified exampl0008.

  9. Performance and review of safety assessment for decommissioning

    SciTech Connect

    Percival, K.; Thierfeldt, S.; Joubert, A.; Kaulard, J.; Manson, P.; Ferch, R.; Batandjieva, B.

    2007-07-01

    Available in abstract form only. Full text of publication follows: Safety assessment is required by national and international safety standards to be performed for all stages of life cycle of facilities that are using radioactive material. It is required to be performed by operators and reviewed by regulators in support of a decommissioning plan for every facility before decommissioning commences. With the growing amount of decommissioning activities world-wide, the need for assistance to Member States in development and review of such assessments was highlighted in the Berlin Conference in 2002 and reflected in the International Action Plan on Decommissioning of Nuclear Facilities, approved by the International Atomic Energy Agency (IAEA) Board of Governors in 2004. In order to respond to this need, the IAEA initiated an international project on Evaluation and Demonstration of Safety during Decommissioning of Nuclear Facilities (DeSa Project) in the same year. More than fifty experts from over thirty Member States have been working over the last three years on (i) the establishment of a harmonized safety assessment methodology for decommissioning; (ii) development of recommendations for a regulatory approach and procedure for review of such assessments; (iii) development of recommendations on the application of the graded approach to development and review of safety assessments; and (iv) application of the methodology, the regulatory review procedure and graded approach recommendations to three test cases - safety assessment for decommissioning of a nuclear power plant (NPP), a research reactor and a nuclear laboratory. This paper presents the current status of the DeSa project work, the consensus achieved, the main preliminary outcomes and lessons learned. The project results are envisaged to be presented and discussed at the 4. Joint DeSa meeting in October 2007 in Vienna, where the scope and objectives of a follow- up project will be also discussed. (authors)

  10. Employee Turnover: An Empirical and Methodological Assessment.

    ERIC Educational Resources Information Center

    Muchinsky, Paul M.; Tuttle, Mark L.

    1979-01-01

    Reviews research on the prediction of employee turnover. Groups predictor variables into five general categories: attitudinal (job satisfaction), biodata, work-related, personal, and test-score predictors. Consistent relationships between common predictor variables and turnover were found for four categories. Eight methodological problems/issues…

  11. Influence Map Methodology for Evaluating Systemic Safety Issues

    NASA Technical Reports Server (NTRS)

    2008-01-01

    "Raising the bar" in safety performance is a critical challenge for many organizations, including Kennedy Space Center. Contributing-factor taxonomies organize information about the reasons accidents occur and therefore are essential elements of accident investigations and safety reporting systems. Organizations must balance efforts to identify causes of specific accidents with efforts to evaluate systemic safety issues in order to become more proactive about improving safety. This project successfully addressed the following two problems: (1) methods and metrics to support the design of effective taxonomies are limited and (2) influence relationships among contributing factors are not explicitly modeled within a taxonomy.

  12. Risk assessment methodologies for nuclear weapons compared to risk assessment methodologies for nuclear reactors

    SciTech Connect

    Benjamin, A.S.

    1994-12-31

    There are major differences between the safety principles for nuclear weapons and for nuclear reactors. For example, a principal concern for nuclear weapons is to prevent electrical energy from reaching the nuclear package during accidents produced by crashes, fires, and other hazards, whereas the foremost concern for nuclear reactors is to maintain coolant around the core in the event of certain system failures. Not surprisingly, new methods have had to be developed to assess the risk from nuclear weapons. These include fault tree transformations that accommodate time dependencies, thermal and structural analysis techniques that are fast and unconditionally stable, and Monte-Carlo-based sampling methods that incorporate intelligent searching. This paper provides an overview of the new methods for nuclear weapons, compares them with existing methods for nuclear reactors, identifies some of their dual-use characteristics, and discusses ongoing developmental activities.

  13. SYNTHESIS OF SAFETY ANALYSIS AND FIRE HAZARD ANALYSIS METHODOLOGIES

    SciTech Connect

    Coutts, D

    2007-04-17

    Successful implementation of both the nuclear safety program and fire protection program is best accomplished using a coordinated process that relies on sound technical approaches. When systematically prepared, the documented safety analysis (DSA) and fire hazard analysis (FHA) can present a consistent technical basis that streamlines implementation. If not coordinated, the DSA and FHA can present inconsistent conclusions, which can create unnecessary confusion and can promulgate a negative safety perception. This paper will compare the scope, purpose, and analysis techniques for DSAs and FHAs. It will also consolidate several lessons-learned papers on this topic, which were prepared in the 1990s.

  14. QAM: A Competency Based Need Assessment Methodology and Computer Program.

    ERIC Educational Resources Information Center

    Gale, Larrie E.

    A needs assessment methodology is described which can be used (1) to assess the competencies required for functioning in a particular position, (2) to provide data for planning inservice and preservice educational programs, (3) to assess job performance, and (4) to provide information for personnel planners. Quadrants are formed using four…

  15. 45 CFR 308.1 - Self-assessment implementation methodology.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Self-assessment implementation methodology. 308.1... HUMAN SERVICES ANNUAL STATE SELF-ASSESSMENT REVIEW AND REPORT § 308.1 Self-assessment implementation... responsibility for and control of the results produced and contents of the annual report. (b) Sampling. A...

  16. DRAFT METHODOLOGY FOR CONDUCTING RISK ASSESSMENTS AT ASBESTOS SUPERFUND SITES

    EPA Science Inventory

    The document will be an updated draft metholodogy for cancer risk assessment of asbestos. The draft methodology will address potential differences in cancer potency of different fiber types and different fiber dimensions of asbestos.

  17. Hanford Site baseline risk assessment methodology. Revision 2

    SciTech Connect

    Not Available

    1993-03-01

    This methodology has been developed to prepare human health and environmental evaluations of risk as part of the Comprehensive Environmental Response, Compensation, and Liability Act remedial investigations (RIs) and the Resource Conservation and Recovery Act facility investigations (FIs) performed at the Hanford Site pursuant to the Hanford Federal Facility Agreement and Consent Order referred to as the Tri-Party Agreement. Development of the methodology has been undertaken so that Hanford Site risk assessments are consistent with current regulations and guidance, while providing direction on flexible, ambiguous, or undefined aspects of the guidance. The methodology identifies Site-specific risk assessment considerations and integrates them with approaches for evaluating human and environmental risk that can be factored into the risk assessment program supporting the Hanford Site cleanup mission. Consequently, the methodology will enhance the preparation and review of individual risk assessments at the Hanford Site.

  18. Hydrogen Hazards Assessment Protocol (HHAP): Approach and Methodology

    NASA Technical Reports Server (NTRS)

    Woods, Stephen

    2009-01-01

    This viewgraph presentation reviews the approach and methodology to develop a assessment protocol for hydrogen hazards. Included in the presentation are the reasons to perform hazards assessment, the types of hazard assessments that exist, an analysis of hydrogen hazards, specific information about the Hydrogen Hazards Assessment Protocol (HHAP). The assessment is specifically tailored for hydrogen behavior. The end product of the assesment is a compilation of hazard, mitigations and associated factors to facilitate decision making and achieve the best practice.

  19. Challenges and methodology for safety analysis of a high-level waste tank with large periodic releases of flammable gas

    SciTech Connect

    Edwards, J.N.; Pasamehmetoglu, K.O.; White, J.R.; Stewart, C.W.

    1994-07-01

    Tank 241-SY-101, located at the Department of Energy Hanford Site, has periodically released up to 10,000 ft{sup 3} of flammable gas. This release has been one of the highest-priority DOE operational safety problems. The gases include hydrogen and ammonia (fuels) and nitrous oxide (oxidizer). There have been many opinions regarding the controlling mechanisms for these releases, but demonstrating an adequate understanding of the problem, selecting a mitigation methodology, and preparing the safety analysis have presented numerous new challenges. The mitigation method selected for the tank was to install a pump that would mix the tank contents and eliminate the sludge layer believed to be responsible for the gas retention and periodic releases. This report will describe the principal analysis methodologies used to prepare the safety assessment for the installation and operation of the pump, and because this activity has been completed, it will describe the results of pump operation.

  20. Assessment of cognitive safety in clinical drug development

    PubMed Central

    Roiser, Jonathan P.; Nathan, Pradeep J.; Mander, Adrian P.; Adusei, Gabriel; Zavitz, Kenton H.; Blackwell, Andrew D.

    2016-01-01

    Cognitive impairment is increasingly recognised as an important potential adverse effect of medication. However, many drug development programmes do not incorporate sensitive cognitive measurements. Here, we review the rationale for cognitive safety assessment, and explain several basic methodological principles for measuring cognition during clinical drug development, including study design and statistical analysis, from Phase I through to postmarketing. The crucial issue of how cognition should be assessed is emphasized, especially the sensitivity of measurement. We also consider how best to interpret the magnitude of any identified effects, including comparison with benchmarks. We conclude by discussing strategies for the effective communication of cognitive risks. PMID:26610416

  1. An assessment methodology for thermal energy storage evaluation

    NASA Astrophysics Data System (ADS)

    Brown, D. R.; Dirks, J. A.; Drost, M. K.; Spanner, G. E.; Williams, T. A.

    1987-11-01

    This report documents an assessment methodology for evaluating the cost, performance, and overall economic feasibility of thermal energy storage (TES) concepts. The methodology was developed by Thermal Energy Storage Evaluation Program personnel at Pacific Northwest Laboratory (PNL) for use by PNL and other TES concept evaluators. The methodology is generically applicable to all TES concepts; however, specific analyses may require additional or more detailed definition of the ground rules, assumptions, and analytical approach. The overall objective of the assessment methodology is to assist in preparing equitable and proper evaluations of TES concepts that will allow developers and end-users to make valid decisions about research and development (R and D) and implementation. The methodology meets this objective by establishing standard approaches, ground rules, assumptions, and definitions that are analytically correct and can be consistently applied by concept evaluators.

  2. An assessment methodology for thermal energy storage evaluation

    SciTech Connect

    Brown, D.R.; Dirks, J.A.; Drost, M.K.; Spanner, G.E.; Williams, T.A.

    1987-11-01

    This report documents an assessment methodology for evaluating the cost, performance, and overall economic feasibility of thermal energy storage (TES) concepts. The methodology was developed by Thermal Energy Storage Evaluation Program personnel at Pacific Northwest Laboratory (PNL) for use by PNL and other TES concept evaluators. The methodology is generically applicable to all TES concepts; however, specific analyses may require additional or more detailed definition of the ground rules, assumptions, and analytical approach. The overall objective of the assessment methodology is to assist in preparing equitable and proper evaluations of TES concepts that will allow developers and end-users to make valid decisions about research and development (R and D) and implementation. The methodology meets this objective by establishing standard approaches, ground rules, assumptions, and definitions that are analytically correct and can be consistently applied by concept evaluators. 15 refs., 4 figs., 13 tabs.

  3. Institutional Financial Assessment: Methodology and Meaning.

    ERIC Educational Resources Information Center

    Jenny, Hans H.

    1979-01-01

    W. John Minter and Howard R. Bowen's annual report on "Financial and Educational Trends in Independent Higher Education, 1978" is examined. Problems in data reporting by college administrators that skew financial assessment reports are noted. A rating questionnaire for institutional quality is appended. (Author/LBH)

  4. Probabilistic Safety Assessment of Tehran Research Reactor

    SciTech Connect

    Hosseini, Seyed Mohammad Hadi; Nematollahi, Mohammad Reza; Sepanloo, Kamran

    2004-07-01

    Probabilistic Safety Assessment (PSA) application is found to be a practical tool for research reactor safety due to intense involvement of human interactions in an experimental facility. In this paper the application of the Probabilistic Safety Assessment to the Tehran Research Reactor (TRR) is presented. The level 1 PSA application involved: Familiarization with the plant, selection of accident initiators, mitigating functions and system definitions, event tree constructions and quantification, fault tree constructions and quantification, human reliability, component failure data base development and dependent failure analysis. Each of the steps of the analysis given above is discussed with highlights from the selected results. Quantification of the constructed models is done using SAPHIRE software. This Study shows that the obtained core damage frequency for Tehran Research Reactor (8.368 E-6 per year) well meets the IAEA criterion for existing nuclear power plants (1E-4). But safety improvement suggestions are offered to decrease the most probable accidents. (authors)

  5. Space Transportation Operations: Assessment of Methodologies and Models

    NASA Technical Reports Server (NTRS)

    Joglekar, Prafulla

    2002-01-01

    The systems design process for future space transportation involves understanding multiple variables and their effect on lifecycle metrics. Variables such as technology readiness or potential environmental impact are qualitative, while variables such as reliability, operations costs or flight rates are quantitative. In deciding what new design concepts to fund, NASA needs a methodology that would assess the sum total of all relevant qualitative and quantitative lifecycle metrics resulting from each proposed concept. The objective of this research was to review the state of operations assessment methodologies and models used to evaluate proposed space transportation systems and to develop recommendations for improving them. It was found that, compared to the models available from other sources, the operations assessment methodology recently developed at Kennedy Space Center has the potential to produce a decision support tool that will serve as the industry standard. Towards that goal, a number of areas of improvement in the Kennedy Space Center's methodology are identified.

  6. Space Transportation Operations: Assessment of Methodologies and Models

    NASA Technical Reports Server (NTRS)

    Joglekar, Prafulla

    2001-01-01

    The systems design process for future space transportation involves understanding multiple variables and their effect on lifecycle metrics. Variables such as technology readiness or potential environmental impact are qualitative, while variables such as reliability, operations costs or flight rates are quantitative. In deciding what new design concepts to fund, NASA needs a methodology that would assess the sum total of all relevant qualitative and quantitative lifecycle metrics resulting from each proposed concept. The objective of this research was to review the state of operations assessment methodologies and models used to evaluate proposed space transportation systems and to develop recommendations for improving them. It was found that, compared to the models available from other sources, the operations assessment methodology recently developed at Kennedy Space Center has the potential to produce a decision support tool that will serve as the industry standard. Towards that goal, a number of areas of improvement in the Kennedy Space Center's methodology are identified.

  7. Draft report: a selection methodology for LWR safety R and D programs and proposals

    SciTech Connect

    Husseiny, A. A.; Ritzman, R. L.

    1980-03-01

    The results of work done to develop a methodology for selecting LWR safety R and D programs and proposals is described. A critical survey of relevant decision analysis methods is provided including the specifics of multiattribute utility theory. This latter method forms the basis of the developed selection methodology. Details of the methodology and its use are provided along with a sample illustration of its application.

  8. Environment, safety and health progress assessment manual

    SciTech Connect

    Not Available

    1992-12-01

    On June 27, 1989, the Secretary of Energy announced a 1O-Point Initiative to strengthen environment,safety, and health (ES H) programs, and waste management activities at involved conducting DOE production, research, and testing facilities. One of the points independent Tiger Team Assessments of DOE operating facilities. The Office of Special Projects (OSP), EH-5, in the Office of the Assistant Secretary for Environment, Safety and Health, EH-1, was assigned the responsibility to conduct the Tiger Team Assessments. Through June 1992, a total of 35 Tiger Team Assessments were completed. The Secretary directed that Corrective Action Plans be developed and implemented to address the concerns identified by the Tiger Teams. In March 1991, the Secretary approved a plan for assessments that are more focused, concentrating on ES H management, ES H corrective actions, self-assessment programs, and root-cause related issues.'' In July 1991, the Secretary approved the initiation of ES H Progress Assessments, as a followup to the Tiger Team Assessments, and in the continuing effort to institutionalize the self-assessment process and line management accountability in the ES H areas. This volume contains appendices to the Environment, Safety and Health Progress Assessment Manual.

  9. Environment, safety and health progress assessment manual

    SciTech Connect

    Not Available

    1992-12-01

    On June 27, 1989, the Secretary of Energy announced a 10-Point Initiative to strengthen environment, safety, and health (ES H) programs, and waste management activities at DOE production, research, and testing facilities. One of the points involved conducting dent Tiger Team Assessments of DOE operating facilities. The Office of Special independent Projects (OSP), EH-5, in the Office of the Assistant Secretary for Environment, Safety and Health, EH-1, was assigned the responsibility to conduct the Tiger Team Assessments. Through June 1992, a total of 35 Tiger Team Assessments were completed. The Secretary directed that Corrective Action Plans be developed and implemented to address the concerns identified by the Tiger Teams. In March 1991, the Secretary approved a plan for assessments that are more focused, concentrating on ES H management, ES H corrective actions, self-assessment programs, and root-cause related issues.'' In July 1991, the Secretary approved the initiation of ES H Progress Assessments, as a followup to the Tiger Team Assessments, and in the continuing effort to institutionalize the self-assessment process and line management accountability in the ES H areas. This manual documents the processes to be used to perform the ES H Progress Assessments. It was developed based upon the lessons learned from Tiger Team Assessments, the two pilot Progress Assessments, and Progress Assessments that have been completed. The manual will be updated periodically to reflect lessons learned or changes in policy.

  10. Reliability Modeling Methodology for Independent Approaches on Parallel Runways Safety Analysis

    NASA Technical Reports Server (NTRS)

    Babcock, P.; Schor, A.; Rosch, G.

    1998-01-01

    This document is an adjunct to the final report An Integrated Safety Analysis Methodology for Emerging Air Transport Technologies. That report presents the results of our analysis of the problem of simultaneous but independent, approaches of two aircraft on parallel runways (independent approaches on parallel runways, or IAPR). This introductory chapter presents a brief overview and perspective of approaches and methodologies for performing safety analyses for complex systems. Ensuing chapter provide the technical details that underlie the approach that we have taken in performing the safety analysis for the IAPR concept.

  11. Enhancing the Assessment of Verbal Aggression through Observational Methodology

    ERIC Educational Resources Information Center

    van Dulmen, Manfred H. M.; Mata, Andrea D.; Klipfel, Katherine M.

    2012-01-01

    The assessment of verbal aggression in adolescent and young adult dating relationships has largely relied on self-report methodology. We investigated whether information on verbal aggression derived from an observational assessment would enhance the prediction of romantic relationship satisfaction and dissolution in a sample of young adult dating…

  12. Applying insights from repository safety assessments.

    SciTech Connect

    Swift, Peter N.

    2010-03-01

    Despite decades of international consensus that deep geological disposal is the best option for permanent management of long-lived high-level radioactive wastes, no repositories for used nuclear fuel or high-level waste are in operation. Detailed long-term safety assessments have been completed worldwide for a wide range of repository designs and disposal concepts, however, and valuable insights from these assessments are available to inform future decisions about managing radioactive wastes. Qualitative comparisons among the existing safety assessments for disposal concepts in clay, granite, salt, and unsaturated volcanic tuff show how different geologic settings can be matched with appropriate engineered barrier systems to provide a high degree of confidence in the long-term safety of geologic disposal. Review of individual assessments provides insights regarding the release pathways and radionuclides that are most likely to contribute to estimated doses to humans in the far future for different disposal concepts, and can help focus research and development programs to improve management and disposal technologies. Lessons learned from existing safety assessments may be particularly relevant for informing decisions during the process of selecting potential repository sites.

  13. Safety Assessment for Explosive Risk (SAFER) peer review report.

    SciTech Connect

    Heimdahl, Olaf E. R.; LaHoud, Paul; Chapman, Leon Darrel

    2004-08-01

    At the direction of the Department of Defense Explosives Safety Board (DDESB), a Peer Review Team was established to review the status of development of the risk-based explosives safety siting process and criteria as currently implemented in the software 'Safety Assessment for Explosive Risk (SAFER)' Version 2.1. The objective of the Peer Review Team was to provide an independent evaluation of the components of the SAFER model, the ongoing development of the model and the risk assessment process and criteria. This peer review report addressed procedures; protocols; physical and statistical science algorithms; related documents; and software quality assurance, validation and verification. Overall, the risk-based method in SAFER represents a major improvement in the Department of Defense (DoD) approach to explosives safety management. The DDESB and Risk Based Explosives Safety Criteria Team (RBESCT) have made major strides in developing a methodology, which over time may become a worldwide model. The current status of all key areas of the SAFER code has been logically developed and is defensible. Continued improvement and refinement can be expected as implementation proceeds. A consistent approach to addressing and refining uncertainty in each of the primary areas (probability of event, consequences of event and exposure) will be a very beneficial future activity.

  14. Portable Nanoparticle-Based Sensors for Food Safety Assessment.

    PubMed

    Bülbül, Gonca; Hayat, Akhtar; Andreescu, Silvana

    2015-01-01

    The use of nanotechnology-derived products in the development of sensors and analytical measurement methodologies has increased significantly over the past decade. Nano-based sensing approaches include the use of nanoparticles (NPs) and nanostructures to enhance sensitivity and selectivity, design new detection schemes, improve sample preparation and increase portability. This review summarizes recent advancements in the design and development of NP-based sensors for assessing food safety. The most common types of NPs used to fabricate sensors for detection of food contaminants are discussed. Selected examples of NP-based detection schemes with colorimetric and electrochemical detection are provided with focus on sensors for the detection of chemical and biological contaminants including pesticides, heavy metals, bacterial pathogens and natural toxins. Current trends in the development of low-cost portable NP-based technology for rapid assessment of food safety as well as challenges for practical implementation and future research directions are discussed. PMID:26690169

  15. Portable Nanoparticle-Based Sensors for Food Safety Assessment

    PubMed Central

    Bülbül, Gonca; Hayat, Akhtar; Andreescu, Silvana

    2015-01-01

    The use of nanotechnology-derived products in the development of sensors and analytical measurement methodologies has increased significantly over the past decade. Nano-based sensing approaches include the use of nanoparticles (NPs) and nanostructures to enhance sensitivity and selectivity, design new detection schemes, improve sample preparation and increase portability. This review summarizes recent advancements in the design and development of NP-based sensors for assessing food safety. The most common types of NPs used to fabricate sensors for detection of food contaminants are discussed. Selected examples of NP-based detection schemes with colorimetric and electrochemical detection are provided with focus on sensors for the detection of chemical and biological contaminants including pesticides, heavy metals, bacterial pathogens and natural toxins. Current trends in the development of low-cost portable NP-based technology for rapid assessment of food safety as well as challenges for practical implementation and future research directions are discussed. PMID:26690169

  16. Industrial irradiator radiation safety program assessments

    NASA Astrophysics Data System (ADS)

    Smith, Mark A.

    2000-03-01

    Considerable attention is typically given to radiation safety in the design of irradiators and initially establishing the program. However, one component that may not receive enough attention is applying the continuous improvement philosophy to the radiation safety program. Periodic total program assessments of radiation safety can ensure that the design and implementation of the program continues to be applicable to the operations. The first step in the process must be to determine what is to be covered in the program assessment. While regulatory compliance audits are a component, the most useful evaluation will extend beyond looking only at compliance and determine whether the radiation safety program is the most appropriate for the particular operation. Several aspects of the irradiator operation, not all of which may routinely be considered "radiation safety", per se, should be included: Design aspects of the irradiator and operating system, system controls, and maintenance procedures, as well as the more traditional radiation safety program components such as surveys, measurements and training.

  17. Introduction and summary of the 13th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies.

    PubMed Central

    Stokes, W S; Marafante, E

    1998-01-01

    A workshop on alternative toxicological testing methodologies was convened by the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC) 26-31 January 1997 in Ispra, Italy, at the European Centre for the Validation of Alternative Methods. The purpose of the workshop was to assess the current status of alternative testing methodologies available to evaluate adverse human health and environmental effects of chemicals. Another objective of the workshop was to identify and recommend research needed to fill knowledge gaps that would lead to new test methodologies. Four work groups were established to address conceptual issues, acute toxicity, organ toxicity, and ecotoxicology. A joint workshop report was prepared for each topic and included recommendations for the development and use of alternative methods. Participants concluded that alternative methods and approaches are available that can be incorporated into tiered strategies for toxicological assessments. Use of these methods will reduce the numbers of animals required, and in some instances reduce animal pain and distress. It was recommended that future efforts to develop test methods should emphasize mechanism-based methods that can provide improved predictions of toxicity. Continued international cooperation was encouraged to facilitate future progress in the development of alternative toxicological testing methods. These methods will provide for improvements in human health protection, environmental protection, and animal welfare. PMID:9599686

  18. Methodology for assessing the risk from cable fires

    SciTech Connect

    Apostolakis, G.; Kazarians, M.; Bley, D.C.

    1982-07-01

    A methodology for quantifying the frequency of core melt and containment failure due to fires is developed. Critical areas are identified using as criteria the failures of control and power cables, which may lead to loss-of-coolant accidents and transients and the concurrent loss of redundant engineered safety functions. A detailed analysis of fires in a cable-spreading room, which includes models for growth and suppression, is also presented.

  19. Assessment of methodologies for analysis of the dungeness B accidental aircraft crash risk.

    SciTech Connect

    LaChance, Jeffrey L.; Hansen, Clifford W.

    2010-09-01

    The Health and Safety Executive (HSE) has requested Sandia National Laboratories (SNL) to review the aircraft crash methodology for nuclear facilities that are being used in the United Kingdom (UK). The scope of the work included a review of one method utilized in the UK for assessing the potential for accidental airplane crashes into nuclear facilities (Task 1) and a comparison of the UK methodology against similar International Atomic Energy Agency (IAEA), United States (US) Department of Energy (DOE), and the US Nuclear Regulatory Commission (NRC) methods (Task 2). Based on the conclusions from Tasks 1 and 2, an additional Task 3 would provide an assessment of a site-specific crash frequency for the Dungeness B facility using one of the other methodologies. This report documents the results of Task 2. The comparison of the different methods was performed for the three primary contributors to aircraft crash risk at the Dungeness B site: airfield related crashes, crashes below airways, and background crashes. The methods and data specified in each methodology were compared for each of these risk contributors, differences in the methodologies were identified, and the importance of these differences was qualitatively and quantitatively assessed. The bases for each of the methods and the data used were considered in this assessment process. A comparison of the treatment of the consequences of the aircraft crashes was not included in this assessment because the frequency of crashes into critical structures is currently low based on the existing Dungeness B assessment. Although the comparison found substantial differences between the UK and the three alternative methodologies (IAEA, NRC, and DOE) this assessment concludes that use of any of these alternative methodologies would not change the conclusions reached for the Dungeness B site. Performance of Task 3 is thus not recommended.

  20. Helping High School Students Assess Campus Safety.

    ERIC Educational Resources Information Center

    Roark, Mary L.

    1992-01-01

    Describes campus violence found on college campus, including rape, assault, hazing, harassment, and bias-related violence. Offers set of guidelines to assist high school students in assessing campus safety at colleges and universities they may be considering. Discusses high school counselor's role in providing information and perspectives that…

  1. DOE/EM Criticality Safety Needs Assessment

    SciTech Connect

    Westfall, Robert Michael; Hopper, Calvin Mitchell

    2011-02-01

    The issue of nuclear criticality safety (NCS) in Department of Energy Environmental Management (DOE/EM) fissionable material operations presents challenges because of the large quantities of material present in the facilities and equipment that are committed to storage and/or material conditioning and dispositioning processes. Given the uncertainty associated with the material and conditions for many DOE/EM fissionable material operations, ensuring safety while maintaining operational efficiency requires the application of the most-effective criticality safety practices. In turn, more-efficient implementation of these practices can be achieved if the best NCS technologies are utilized. In 2002, DOE/EM-1 commissioned a survey of criticality safety technical needs at the major EM sites. These needs were documented in the report Analysis of Nuclear Criticality Safety Technology Supporting the Environmental Management Program, issued May 2002. Subsequent to this study, EM safety management personnel made a commitment to applying the best and latest criticality safety technology, as described by the DOE Nuclear Criticality Safety Program (NCSP). Over the past 7 years, this commitment has enabled the transfer of several new technologies to EM operations. In 2008, it was decided to broaden the basis of the EM NCS needs assessment to include not only current needs for technologies but also NCS operational areas with potential for improvements in controls, analysis, and regulations. A series of NCS workshops has been conducted over the past years, and needs have been identified and addressed by EM staff and contractor personnel. These workshops were organized and conducted by the EM Criticality Safety Program Manager with administrative and technical support by staff at Oak Ridge National Laboratory (ORNL). This report records the progress made in identifying the needs, determining the approaches for addressing these needs, and assimilating new NCS technologies into EM

  2. Safety assessment of high consequence robotics system

    SciTech Connect

    Robinson, D.G.; Atcitty, C.B.

    1996-08-01

    This paper outlines the use of a failure modes and effects analysis for the safety assessment of a robotic system being developed at Sandia National Laboratories. The robotic system, the weigh and leak check system, is to replace a manual process for weight and leakage of nuclear materials at the DOE Pantex facility. Failure modes and effects analyses were completed for the robotics process to ensure that safety goals for the systems have been met. Due to the flexible nature of the robot configuration, traditional failure modes and effects analysis (FMEA) were not applicable. In addition, the primary focus of safety assessments of robotics systems has been the protection of personnel in the immediate area. In this application, the safety analysis must account for the sensitivities of the payload as well as traditional issues. A unique variation on the classical FMEA was developed that permits an organized and quite effective tool to be used to assure that safety was adequately considered during the development of the robotic system. The fundamental aspects of the approach are outlined in the paper.

  3. New methodology for assessing the probability of contaminating Mars

    NASA Technical Reports Server (NTRS)

    North, D. W.; Judd, B. R.; Pezier, J. P.

    1974-01-01

    Methodology is proposed to assess the probability that the planet Mars will be contaminated by terrestrial microorganisms aboard a spacecraft. The present NASA methods are extended to permit utilization of detailed information on microbial characteristics, the lethality of release and transport mechanisms, and of other information about the Martian environment. Different types of microbial release are distinguished, and for each release mechanism a probability of growth is computed. Using this new methodology, an assessment was carried out for the 1975 Viking landings on Mars. The resulting probability of contamination for each Viking lander is 6 x 10 to the -6 power, and is amenable to revision as additional information becomes available.

  4. Regional issue identification and assessment: study methodology. First annual report

    SciTech Connect

    Not Available

    1980-01-01

    The overall assessment methodologies and models utilized for the first project under the Regional Issue Identification and Assessment (RIIA) program are described. Detailed descriptions are given of the methodologies used by lead laboratories for the quantification of the impacts of an energy scenario on one or more media (e.g., air, water, land, human and ecology), and by all laboratories to assess the regional impacts on all media. The research and assessments reflected in this document were performed by the following national laboratories: Argonne National Laboratory; Brookhaven National Laboratory; Lawrence Berkeley Laboratory; Los Alamos Scientific Laboratory; Oak Ridge National Laboratory; and Pacific Northwest Laboratory. This report contains five chapters. Chapter 1 briefly describes the overall study methodology and introduces the technical participants. Chapter 2 is a summary of the energy policy scenario selected for the RIIA I study and Chapter 3 describes how this scenario was translated into a county-level siting pattern of energy development. The fourth chapter is a detailed description of the individual methodologies used to quantify the environmental and socioeconomic impacts of the scenario while Chapter 5 describes how these impacts were translated into comprehensive regional assessments for each Federal Region.

  5. Reactor Accident Analysis Methodology for the Advanced Test Reactor Critical Facility Documented Safety Analysis Upgrade

    SciTech Connect

    Gregg L. Sharp; R. T. McCracken

    2003-06-01

    The regulatory requirement to develop an upgraded safety basis for a DOE nuclear facility was realized in January 2001 by issuance of a revision to Title 10 of the Code of Federal Regulations Section 830 (10 CFR 830).1 Subpart B of 10 CFR 830, “Safety Basis Requirements,” requires a contractor responsible for a DOE Hazard Category 1, 2, or 3 nuclear facility to either submit by April 9, 2001 the existing safety basis which already meets the requirements of Subpart B, or to submit by April 10, 2003 an upgraded facility safety basis that meets the revised requirements.1 10 CFR 830 identifies Nuclear Regulatory Commission (NRC) Regulatory Guide 1.70, “Standard Format and Content of Safety Analysis Reports for Nuclear Power Plants”2 as a safe harbor methodology for preparation of a DOE reactor documented safety analysis (DSA). The regulation also allows for use of a graded approach. This report presents the methodology that was developed for preparing the reactor accident analysis portion of the Advanced Test Reactor Critical Facility (ATRC) upgraded DSA. The methodology was approved by DOE for developing the ATRC safety basis as an appropriate application of a graded approach to the requirements of 10 CFR 830.

  6. Reactor Accident Analysis Methodology for the Advanced Test Reactor Critical Facility Documented Safety Analysis Upgrade

    SciTech Connect

    Sharp, G.L.; McCracken, R.T.

    2003-05-13

    The regulatory requirement to develop an upgraded safety basis for a DOE Nuclear Facility was realized in January 2001 by issuance of a revision to Title 10 of the Code of Federal Regulations Section 830 (10 CFR 830). Subpart B of 10 CFR 830, ''Safety Basis Requirements,'' requires a contractor responsible for a DOE Hazard Category 1, 2, or 3 nuclear facility to either submit by April 9, 2001 the existing safety basis which already meets the requirements of Subpart B, or to submit by April 10, 2003 an upgraded facility safety basis that meets the revised requirements. 10 CFR 830 identifies Nuclear Regulatory Commission (NRC) Regulatory Guide 1.70, ''Standard Format and Content of Safety Analysis Reports for Nuclear Power Plants'' as a safe harbor methodology for preparation of a DOE reactor documented safety analysis (DSA). The regulation also allows for use of a graded approach. This report presents the methodology that was developed for preparing the reactor accident analysis portion of the Advanced Test Reactor Critical Facility (ATRC) upgraded DSA. The methodology was approved by DOE for developing the ATRC safety basis as an appropriate application of a graded approach to the requirements of 10 CFR 830.

  7. A methodology for the assessment of manned flight simulator fidelity

    NASA Technical Reports Server (NTRS)

    Hess, Ronald A.; Malsbury, Terry N.

    1989-01-01

    A relatively simple analytical methodology for assessing the fidelity of manned flight simulators for specific vehicles and tasks is offered. The methodology is based upon an application of a structural model of the human pilot, including motion cue effects. In particular, predicted pilot/vehicle dynamic characteristics are obtained with and without simulator limitations. A procedure for selecting model parameters can be implemented, given a probable pilot control strategy. In analyzing a pair of piloting tasks for which flight and simulation data are available, the methodology correctly predicted the existence of simulator fidelity problems. The methodology permitted the analytical evaluation of a change in simulator characteristics and indicated that a major source of the fidelity problems was a visual time delay in the simulation.

  8. Risk Assessment and Alternatives Assessment: Comparing Two Methodologies

    PubMed Central

    2015-01-01

    The selection and use of chemicals and materials with less hazardous profiles reflects a paradigm shift from reliance on risk minimization through exposure controls to hazard avoidance. This article introduces risk assessment and alternatives assessment frameworks in order to clarify a misconception that alternatives assessment is a less effective tool to guide decision making, discusses factors promoting the use of each framework, and also identifies how and when application of each framework is most effective. As part of an assessor's decision process to select one framework over the other, it is critical to recognize that each framework is intended to perform different functions. Although the two frameworks share a number of similarities (such as identifying hazards and assessing exposure), an alternatives assessment provides a more realistic framework with which to select environmentally preferable chemicals because of its primary reliance on assessing hazards and secondary reliance on exposure assessment. Relevant to other life cycle impacts, the hazard of a chemical is inherent, and although it may be possible to minimize exposure (and subsequently reduce risk), it is challenging to assess such exposures through a chemical's life cycle. Through increased use of alternatives assessments at the initial stage of material or product design, there will be less reliance on post facto risk‐based assessment techniques because the potential for harm is significantly reduced, if not avoided, negating the need for assessing risk in the first place. PMID:26694655

  9. Ultraviolet safety assessments of insect light traps.

    PubMed

    Sliney, David H; Gilbert, David W; Lyon, Terry

    2016-06-01

    Near-ultraviolet (UV-A: 315-400 nm), "black-light," electric lamps were invented in 1935 and ultraviolet insect light traps (ILTs) were introduced for use in agriculture around that time. Today ILTs are used indoors in several industries and in food-service as well as in outdoor settings. With recent interest in photobiological lamp safety, safety standards are being developed to test for potentially hazardous ultraviolet emissions. A variety of UV "Black-light" ILTs were measured at a range of distances to assess potential exposures. Realistic time-weighted human exposures are shown to be well below current guidelines for human exposure to ultraviolet radiation. These UV-A exposures would be far less than the typical UV-A exposure in the outdoor environment. Proposals are made for realistic ultraviolet safety standards for ILT products. PMID:27043058

  10. Ultraviolet safety assessments of insect light traps

    PubMed Central

    Sliney, David H.; Gilbert, David W.; Lyon, Terry

    2016-01-01

    ABSTRACT Near-ultraviolet (UV-A: 315–400 nm), “black-light,” electric lamps were invented in 1935 and ultraviolet insect light traps (ILTs) were introduced for use in agriculture around that time. Today ILTs are used indoors in several industries and in food-service as well as in outdoor settings. With recent interest in photobiological lamp safety, safety standards are being developed to test for potentially hazardous ultraviolet emissions. A variety of UV “Black-light” ILTs were measured at a range of distances to assess potential exposures. Realistic time-weighted human exposures are shown to be well below current guidelines for human exposure to ultraviolet radiation. These UV-A exposures would be far less than the typical UV-A exposure in the outdoor environment. Proposals are made for realistic ultraviolet safety standards for ILT products. PMID:27043058

  11. Methodological Issues in Assessing Resilience in Maltreated Children.

    ERIC Educational Resources Information Center

    Kinard, E. Milling

    1998-01-01

    Discusses methodological difficulties in assessing resilience in maltreated children, including distinguishing between resilience and factors promoting or reducing resilience, choosing sources of measures, determining how many measures to use, selecting scoring criteria, determining when to measure resilience, and examining the stability of…

  12. Methodological Concerns about the Education Value-Added Assessment System

    ERIC Educational Resources Information Center

    Amrein-Beardsley, Audrey

    2008-01-01

    Value-added models help to evaluate the knowledge that school districts, schools, and teachers add to student learning as students progress through school. In this article, the well-known Education Value-Added Assessment System (EVAAS) is examined. The author presents a practical investigation of the methodological issues associated with the…

  13. A Methodological Proposal for Learning Games Selection and Quality Assessment

    ERIC Educational Resources Information Center

    Dondi, Claudio; Moretti, Michela

    2007-01-01

    This paper presents a methodological proposal elaborated in the framework of two European projects dealing with game-based learning, both of which have focused on "quality" aspects in order to create suitable tools that support European educators, practitioners and lifelong learners in selecting and assessing learning games for use in teaching and…

  14. Critical Inquiry and Writing Centers: A Methodology of Assessment

    ERIC Educational Resources Information Center

    Bell, Diana Calhoun; Frost, Alanna

    2012-01-01

    By examining one writing center's role in student success, this project offers two examples of the way writing centers impact student engagement. This analysis models a methodology that writing and learning center directors can utilize in order to foster effective communication with stakeholders. By conducting data-driven assessment, directors can…

  15. DEVELOPMENT OF RISK ASSESSMENT METHODOLOGY FOR MUNICIPAL SLUDGE INCINERATION

    EPA Science Inventory

    This is one of a series of reports that present methodologies for assessing the potential risks to humans or other organisms from the disposal or reuse of municipal sludge. he sludge management practices addressed by this series include land application practices, distribution an...

  16. DEVELOPMENT OF RISK ASSESSMENT METHODOLOGY FOR MUNICIPAL SLUDGE LANDFILLING

    EPA Science Inventory

    This is one of a series of reports that present methodologies for assessing the potential risks to humans or other organisms from the disposal or reuse of municipal sludge. he sludge management practices addressed by this series include land application practices, distribution an...

  17. Personality Assessment of Global Talent: Conceptual and Methodological Issues

    ERIC Educational Resources Information Center

    van de Vijver, Fons J. R.

    2008-01-01

    The recruitment of managers who will operate in a culturally heterogeneous context (as expatriate managers, managers in a global company, or managers of a multicultural workforce) is increasingly important in an age of globalization. This article describes conceptual and methodological issues in the assessment of such managers, notably in the…

  18. Methodological Issues in Curriculum-Based Reading Assessment.

    ERIC Educational Resources Information Center

    Fuchs, Lynn S.; And Others

    1984-01-01

    Three studies involving elementary students examined methodological issues in curriculum-based reading assessment. Results indicated that (1) whereas sample duration did not affect concurrent validity, increasing duration reduced performance instability and increased performance slopes and (2) domain size was related inversely to performance slope…

  19. Improving Medication Administration Safety in a Community Hospital Setting Using Lean Methodology.

    PubMed

    Critchley, Sandy

    2015-01-01

    Virtually all health care organizations have goals of improving patient safety, but despite clear goals and considerable investments, gains have been limited. This article explores a community hospital's resounding success using Lean methodology to improve medication administration safety with process changes designed by engaged employees and leaders with the knowledge and skill to effect improvements. This article inspires an interdisciplinary approach to quality improvement using reproducible strategies. PMID:25599523

  20. Safety assessment of probiotics for human use

    PubMed Central

    Akkermans, Louis MA; Haller, Dirk; Hammerman, Cathy; Heimbach, James; Hörmannsperger, Gabriele; Huys, Geert; Levy, Dan D; Lutgendorff, Femke; Mack, David; Phothirath, Phoukham; Solano-Aguilar, Gloria; Vaughan, Elaine

    2010-01-01

    The safety of probiotics is tied to their intended use, which includes consideration of potential vulnerability of the consumer or patient, dose and duration of consumption, and both the manner and frequency of administration. Unique to probiotics is that they are alive when administered, and unlike other food or drug ingredients, possess the potential for infectivity or in situ toxin production. Since numerous types of microbes are used as probiotics, safety is also intricately tied to the nature of the specific microbe being used. The presence of transferable antibiotic resistance genes, which comprises a theoretical risk of transfer to a less innocuous member of the gut microbial community, must also be considered. Genetic stability of the probiotic over time, deleterious metabolic activities, and the potential for pathogenicity or toxicogenicity must be assessed depending on the characteristics of the genus and species of the microbe being used. Immunological effects must be considered, especially in certain vulnerable populations, including infants with undeveloped immune function. A few reports about negative probiotic effects have surfaced, the significance of which would be better understood with more complete understanding of the mechanisms of probiotic interaction with the host and colonizing microbes. Use of readily available and low cost genomic sequencing technologies to assure the absence of genes of concern is advisable for candidate probiotic strains. The field of probiotic safety is characterized by the scarcity of studies specifically designed to assess safety contrasted with the long history of safe use of many of these microbes in foods. PMID:21327023

  1. Lunar Surface Habitat Configuration Assessment: Methodology and Observations

    NASA Technical Reports Server (NTRS)

    Carpenter, Amanda

    2008-01-01

    The Lunar Habitat Configuration Assessment evaluated the major habitat approaches that were conceptually developed during the Lunar Architecture Team II Study. The objective of the configuration assessment was to identify desired features, operational considerations, and risks to derive habitat requirements. This assessment only considered operations pertaining to the lunar surface and did not consider all habitat conceptual designs developed. To examine multiple architectures, the Habitation Focus Element Team defined several adequate concepts which warranted the need for a method to assess the various configurations. The fundamental requirement designed into each concept included the functional and operational capability to support a crew of four on a six-month lunar surface mission; however, other conceptual aspects were diverse in comparison. The methodology utilized for this assessment consisted of defining figure of merits, providing relevant information, and establishing a scoring system. In summary, the assessment considered the geometric configuration of each concept to determine the complexity of unloading, handling, mobility, leveling, aligning, mating to other elements, and the accessibility to the lunar surface. In theory, the assessment was designed to derive habitat requirements, potential technology development needs and identify risks associated with living and working on the lunar surface. Although the results were more subjective opposed to objective, the assessment provided insightful observations for further assessments and trade studies of lunar surface habitats. This overall methodology and resulting observations will be describe in detail and illustrative examples will be discussed.

  2. Training and Action for Patient Safety: Embedding Interprofessional Education for Patient Safety within an Improvement Methodology

    ERIC Educational Resources Information Center

    Slater, Beverley L.; Lawton, Rebecca; Armitage, Gerry; Bibby, John; Wright, John

    2012-01-01

    Introduction: Despite an explosion of interest in improving safety and reducing error in health care, one important aspect of patient safety that has received little attention is a systematic approach to education and training for the whole health care workforce. This article describes an evaluation of an innovative multiprofessional, team-based…

  3. Spanish methodological approach for biosphere assessment of radioactive waste disposal.

    PubMed

    Agüero, A; Pinedo, P; Cancio, D; Simón, I; Moraleda, M; Pérez-Sánchez, D; Trueba, C

    2007-10-01

    The development of radioactive waste disposal facilities requires implementation of measures that will afford protection of human health and the environment over a specific temporal frame that depends on the characteristics of the wastes. The repository design is based on a multi-barrier system: (i) the near-field or engineered barrier, (ii) far-field or geological barrier and (iii) the biosphere system. Here, the focus is on the analysis of this last system, the biosphere. A description is provided of conceptual developments, methodological aspects and software tools used to develop the Biosphere Assessment Methodology in the context of high-level waste (HLW) disposal facilities in Spain. This methodology is based on the BIOMASS "Reference Biospheres Methodology" and provides a logical and systematic approach with supplementary documentation that helps to support the decisions necessary for model development. It follows a five-stage approach, such that a coherent biosphere system description and the corresponding conceptual, mathematical and numerical models can be built. A discussion on the improvements implemented through application of the methodology to case studies in international and national projects is included. Some facets of this methodological approach still require further consideration, principally an enhanced integration of climatology, geography and ecology into models considering evolution of the environment, some aspects of the interface between the geosphere and biosphere, and an accurate quantification of environmental change processes and rates. PMID:17588645

  4. Animal-Free Chemical Safety Assessment.

    PubMed

    Loizou, George D

    2016-01-01

    The exponential growth of the Internet of Things and the global popularity and remarkable decline in cost of the mobile phone is driving the digital transformation of medical practice. The rapidly maturing digital, non-medical world of mobile (wireless) devices, cloud computing and social networking is coalescing with the emerging digital medical world of omics data, biosensors and advanced imaging which offers the increasingly realistic prospect of personalized medicine. Described as a potential "seismic" shift from the current "healthcare" model to a "wellness" paradigm that is predictive, preventative, personalized and participatory, this change is based on the development of increasingly sophisticated biosensors which can track and measure key biochemical variables in people. Additional key drivers in this shift are metabolomic and proteomic signatures, which are increasingly being reported as pre-symptomatic, diagnostic and prognostic of toxicity and disease. These advancements also have profound implications for toxicological evaluation and safety assessment of pharmaceuticals and environmental chemicals. An approach based primarily on human in vivo and high-throughput in vitro human cell-line data is a distinct possibility. This would transform current chemical safety assessment practice which operates in a human "data poor" to a human "data rich" environment. This could also lead to a seismic shift from the current animal-based to an animal-free chemical safety assessment paradigm. PMID:27493630

  5. Animal-Free Chemical Safety Assessment

    PubMed Central

    Loizou, George D.

    2016-01-01

    The exponential growth of the Internet of Things and the global popularity and remarkable decline in cost of the mobile phone is driving the digital transformation of medical practice. The rapidly maturing digital, non-medical world of mobile (wireless) devices, cloud computing and social networking is coalescing with the emerging digital medical world of omics data, biosensors and advanced imaging which offers the increasingly realistic prospect of personalized medicine. Described as a potential “seismic” shift from the current “healthcare” model to a “wellness” paradigm that is predictive, preventative, personalized and participatory, this change is based on the development of increasingly sophisticated biosensors which can track and measure key biochemical variables in people. Additional key drivers in this shift are metabolomic and proteomic signatures, which are increasingly being reported as pre-symptomatic, diagnostic and prognostic of toxicity and disease. These advancements also have profound implications for toxicological evaluation and safety assessment of pharmaceuticals and environmental chemicals. An approach based primarily on human in vivo and high-throughput in vitro human cell-line data is a distinct possibility. This would transform current chemical safety assessment practice which operates in a human “data poor” to a human “data rich” environment. This could also lead to a seismic shift from the current animal-based to an animal-free chemical safety assessment paradigm. PMID:27493630

  6. 78 FR 14912 - International Aviation Safety Assessment (IASA) Program Change

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... Federal Aviation Administration 14 CFR Part 129 International Aviation Safety Assessment (IASA) Program... statement describes a policy change to the FAA's International Aviation Safety Assessment (IASA) program... INFORMATION CONTACT: Manager of the International Programs and Policy Division (AFS-50), Flight...

  7. Methodology and tools for source term assessment in case of emergency.

    PubMed

    Herviou, Karine; Calmtorp, Christer

    2004-01-01

    By looking at the power plant state of fission product barriers and critical safety systems, the magnitude of a potential radioactive release could be predicted in a timely manner to allow emergency response to be executed even before the occurrence of a release. This is the perspective in which the development of ASTRID methodology and tool is performed. The methodology maps out, for several reactor types as well as reactor containments, relevant process parameters and indicators, what and how to calculate and a structured way to summarise and conclude on potential source term and likely time projections. A computer tool is proposed to support the methodology, to suite different user situations, both on-site and off-site as well as size of staff, priority and work order. The output from such an assessment is intended to, first, give bases for decisions on necessary urgent protective actions pre-release, and, second, an input for the sophisticated dispersion calculation codes. PMID:15238656

  8. Comprehensive methodology for ecological risk assessment of contaminated soils

    SciTech Connect

    Kuperman, R.G.

    1994-12-31

    Development of a comprehensive methodology for ecological risk assessment and monitoring of contaminated soils is essential to assess the impacts of environmental contaminants on soil community and biologically-mediated processes in soil. The proposed four-step plan involves (1) a thorough survey of the soil community to establish biodiversity and a base-line community structure, (2) toxicity trials on indicator species and whole soil invertebrate communities, (3) laboratory and field tests on indicator processes and (4) the use of statistical and simulation models to ascertain changes in the soil ecosystems. This methodology was used in portions of the US Army`s Aberdeen Proving Ground, Maryland as part of an ecological risk assessment. Previous soil analyses showed extensive surface soil contamination with metals, nitrate and PCBs. Preliminary results from field surveys of soil invertebrate communities showed significant reductions in total abundance of animals, reductions in the abundance of several taxonomic and functional groups of soil invertebrates, and changes in the activity of epigeic arthropods in contaminated areas when compared with the local ``background`` area. Laboratory tests also demonstrated that microbial activity and success of egg hatching of ground beetle Harpalus pensylvanicus were reduced in contaminated soils. These results suggest that impacts to soil ecosystems should be explicitly considered in ecological risk assessment. The proposed comprehensive methodology appears to offer an efficient and potentially cost saving tool for remedial investigations of contaminated sites.

  9. Safety assessment for TA-48 radiochemical operations

    SciTech Connect

    1994-08-01

    The purpose of this report is to document an assessment performed to evaluate the safety of the radiochemical operations conducted at the Los Alamos National Laboratory operations area designated as TA-48. This Safety Assessment for the TA-48 radiochemical operations was prepared to fulfill the requirements of US Department of Energy (DOE) Order 5481.1B, ``Safety Analysis and Review System.`` The area designated as TA-48 is operated by the Chemical Science and Technology (CST) Division and is involved with radiochemical operations associated with nuclear weapons testing, evaluation of samples collected from a variety of environmental sources, and nuclear medicine activities. This report documents a systematic evaluation of the hazards associated with the radiochemical operations that are conducted at TA-48. The accident analyses are limited to evaluation of the expected consequences associated with a few bounding accident scenarios that are selected as part of the hazard analysis. Section 2 of this report presents an executive summary and conclusions, Section 3 presents pertinent information concerning the TA-48 site and surrounding area, Section 4 presents a description of the TA-48 radiochemical operations, and Section 5 presents a description of the individual facilities. Section 6 of the report presents an evaluation of the hazards that are associated with the TA-48 operations and Section 7 presents a detailed analysis of selected accident scenarios.

  10. Preliminary assessment of the safety of IFMIF

    NASA Astrophysics Data System (ADS)

    Taylor, N. P.; Brañas, B.; Eriksson, E.; Natalizio, A.; Pinna, T.; Rodríguez-Rodrigo, L.; Ciattaglia, S.; Lässer, R.

    2007-08-01

    The International Fusion Materials Irradiation Facility (IFMIF) is a planned high-energy neutron source for the testing of candidate materials for future fusion power plants. Safety studies performed during the various stages of the conceptual design of IFMIF have been brought together in a preliminary assessment of the safety of IFMIF, identifying the principal hazards and the means to prevent or mitigate them. The design is based on dual high-energy deuteron accelerators delivering beams onto a flowing lithium target, in which neutrons are produced through a d-Li stripping reaction. The neutrons irradiate material samples in controlled conditions in a test cell. In all these systems, potential hazards arise, but analyses show that no postulated off-normal event can result in a significant risk of harm to the public. However, care must be taken in forthcoming detailed design development to minimise occupational radiation exposure during IFMIF operation and maintenance.

  11. Reef Fish Survey Techniques: Assessing the Potential for Standardizing Methodologies.

    PubMed

    Caldwell, Zachary R; Zgliczynski, Brian J; Williams, Gareth J; Sandin, Stuart A

    2016-01-01

    Dramatic changes in populations of fishes living on coral reefs have been documented globally and, in response, the research community has initiated efforts to assess and monitor reef fish assemblages. A variety of visual census techniques are employed, however results are often incomparable due to differential methodological performance. Although comparability of data may promote improved assessment of fish populations, and thus management of often critically important nearshore fisheries, to date no standardized and agreed-upon survey method has emerged. This study describes the use of methods across the research community and identifies potential drivers of method selection. An online survey was distributed to researchers from academic, governmental, and non-governmental organizations internationally. Although many methods were identified, 89% of survey-based projects employed one of three methods-belt transect, stationary point count, and some variation of the timed swim method. The selection of survey method was independent of the research design (i.e., assessment goal) and region of study, but was related to the researcher's home institution. While some researchers expressed willingness to modify their current survey protocols to more standardized protocols (76%), their willingness decreased when methodologies were tied to long-term datasets spanning five or more years. Willingness to modify current methodologies was also less common among academic researchers than resource managers. By understanding both the current application of methods and the reported motivations for method selection, we hope to focus discussions towards increasing the comparability of quantitative reef fish survey data. PMID:27111085

  12. Risk Assessment of Cascading Outages: Methodologies and Challenges

    SciTech Connect

    Vaiman, Marianna; Bell, Keith; Chen, Yousu; Chowdhury, Badrul; Dobson, Ian; Hines, Paul; Papic, Milorad; Miller, Stephen; Zhang, Pei

    2012-05-31

    Abstract- This paper is a result of ongoing activity carried out by Understanding, Prediction, Mitigation and Restoration of Cascading Failures Task Force under IEEE Computer Analytical Methods Subcommittee (CAMS). The task force's previous papers are focused on general aspects of cascading outages such as understanding, prediction, prevention and restoration from cascading failures. This is the first of two new papers, which extend this previous work to summarize the state of the art in cascading failure risk analysis methodologies and modeling tools. This paper is intended to be a reference document to summarize the state of the art in the methodologies for performing risk assessment of cascading outages caused by some initiating event(s). A risk assessment should cover the entire potential chain of cascades starting with the initiating event(s) and ending with some final condition(s). However, this is a difficult task and heuristic approaches and approximations have been suggested. This paper discusses different approaches to this and suggests directions for future development of methodologies. The second paper summarizes the state of the art in modeling tools for risk assessment of cascading outages.

  13. Reef Fish Survey Techniques: Assessing the Potential for Standardizing Methodologies

    PubMed Central

    Caldwell, Zachary R.; Zgliczynski, Brian J.; Williams, Gareth J.; Sandin, Stuart A.

    2016-01-01

    Dramatic changes in populations of fishes living on coral reefs have been documented globally and, in response, the research community has initiated efforts to assess and monitor reef fish assemblages. A variety of visual census techniques are employed, however results are often incomparable due to differential methodological performance. Although comparability of data may promote improved assessment of fish populations, and thus management of often critically important nearshore fisheries, to date no standardized and agreed-upon survey method has emerged. This study describes the use of methods across the research community and identifies potential drivers of method selection. An online survey was distributed to researchers from academic, governmental, and non-governmental organizations internationally. Although many methods were identified, 89% of survey-based projects employed one of three methods–belt transect, stationary point count, and some variation of the timed swim method. The selection of survey method was independent of the research design (i.e., assessment goal) and region of study, but was related to the researcher’s home institution. While some researchers expressed willingness to modify their current survey protocols to more standardized protocols (76%), their willingness decreased when methodologies were tied to long-term datasets spanning five or more years. Willingness to modify current methodologies was also less common among academic researchers than resource managers. By understanding both the current application of methods and the reported motivations for method selection, we hope to focus discussions towards increasing the comparability of quantitative reef fish survey data. PMID:27111085

  14. National assessment of geologic carbon dioxide storage resources: methodology implementation

    USGS Publications Warehouse

    Blondes, Madalyn S.; Brennan, Sean T.; Merrill, Matthew D.; Buursink, Marc L.; Warwick, Peter D.; Cahan, Steven M.; Corum, Margo D.; Cook, Troy A.; Craddock, William H.; DeVera, Christina A.; Drake II, Ronald M.; Drew, Lawrence J.; Freeman, P.A.; Lohr, Celeste D.; Olea, Ricardo A.; Roberts-Ashby, Tina L.; Slucher, Ernie R.; Varela, Brian A.

    2013-01-01

    In response to the 2007 Energy Independence and Security Act, the U.S. Geological Survey (USGS) conducted a national assessment of potential geologic storage resources for carbon dioxide (CO2). Storage of CO2 in subsurface saline formations is one important method to reduce greenhouse gas emissions and curb global climate change. This report provides updates and implementation details of the assessment methodology of Brennan and others (2010, http://pubs.usgs.gov/of/2010/1127/) and describes the probabilistic model used to calculate potential storage resources in subsurface saline formations.

  15. Environmental, health and safety assessment of photovoltaics

    NASA Technical Reports Server (NTRS)

    Rose, E. C.

    1983-01-01

    The environmental, health, and safety (E, H and S) concerns associated with the fabrication, deployment, and decommissioning of photovoltaic (PV) systems in terrestial applications are identified and assessed. Discussion is limited to crystalline silicon technologies. The primary E, H, and S concerns that arise during collector fabrication are associated with occupational exposure to materials of undetermined toxicity or to materials that are known to be hazardous, but for which process control technology may be inadequate. Stricter exposure standards are anticipated for some materials and may indicate a need for further control technology development. Minimizing electric shock hazards is a significant concern during system construction, operation and maintenance, and decommissioning.

  16. Safety assessment of outdoor live fire range

    SciTech Connect

    1989-05-01

    The following Safety Assessment (SA) pertains to the outdoor live fire range facility (LFR). The purpose of this facility is to supplement the indoor LFR. In particular it provides capacity for exercises that would be inappropriate on the indoor range. This SA examines the risks that are attendant to the training on the outdoor LFR. The outdoor LFR used by EG&G Mound is privately owned. It is identified as the Miami Valley Shooting Grounds. Mondays are leased for the exclusive use of EG&G Mound.

  17. Effectiveness evaluation methodology for safety processes to enhance organisational culture in hazardous installations.

    PubMed

    Mengolini, A; Debarberis, L

    2008-06-30

    Safety performance indicators are widely collected and used in hazardous installations. The IAEA, OECD and other international organisations have developed approaches that strongly promote deployment of safety performance indicators. These indicators focus mainly on operational performance, but some of them also address organisational and safety culture aspects. However, operators of hazardous installations, in particular those with limited resources and time constraints, often find it difficult to collect the large number of different safety performance indicators. Moreover, they also have difficulties with giving a meaning to the numbers and trends recorded, especially to those that should reflect a positive safety culture. In this light, the aim of this article is to address the need to monitor and assess progress on implementation of a programme to enhance safety and organisational culture. It proposes a specific process-view approach to effectiveness evaluation of organisational and safety culture indicators by means of a multi-level system in which safety processes and staff involvement in defining improvement activities are central. In this way safety becomes fully embedded in staff activities. Key members of personnel become directly involved in identifying and supplying leading indicators relating to their own daily activity and become responsible and accountable for keeping the measurement system alive. Besides use of lagging indicators, particular emphasis is placed on the importance of identifying and selecting leading indicators which can be used to drive safety performance for organisational and safety culture aspects as well. PMID:18241983

  18. Development of methodologies for ensuring structural safety of gas turbines and launch vehicles

    NASA Astrophysics Data System (ADS)

    George, Thomas Joe, Jr.

    The research presented in this dissertation involves two distinct areas. In both cases, optimization techniques provided an important tool to achieve the goal of ensuring structural integrity and safety of gas turbine and launch vehicle systems. In the first area, a novel testing methodology has been developed to assess turbine engine materials fatigue strength. The idea is to accumulate fatigue energy on a base-excited plate specimen at high frequency resonant modes and to complete a fatigue test in a few hours at very low cost. The methodology consists of: (1) a topological design procedure, incorporating a finite element model, to characterize the shape of the specimens for ensuring the required stress state/pattern, (2) a vibration feedback empirical procedure for achieving the high cycle fatigue experiments with variable-amplitude loading, and (3) a fatigue strength implementation scheme for calculating effective stresses and effective number of cycles to failure. The performance of the methodology is demonstrated by the experimental results from steel, 6061-T6 aluminum, and Ti-6Al-4V plate specimens subjected to fully reversed bending for both uniaxial and biaxial stress states. Furthermore, a technique has been developed to produce residual stress enabling vibration-based fatigue testing at various stress ratios. Additionally, this vibration-based fatigue method has the advantage of being able to produce a fatigue crack in the test specimen while it is still in the initiation stage. In the second area, an optimization procedure has been developed to uniquely and efficiently determine the "best" local geometry design of a new composite ChamberCore structure. This procedure is based on minimization of the total mass of a single composite ChamberCore, subject to a set of design and stress constraints. The stress constraints are obtained in closed-form based on the composite box-beam model for various composite lamination designs and loading conditions. The

  19. Risk-Informed Assessment Methodology Development and Application

    SciTech Connect

    Sung Goo Chi; Seok Jeong Park; Chul Jin Choi; Ritterbusch, S.E.; Jacob, M.C.

    2002-07-01

    Westinghouse Electric Company (WEC) has been working with Korea Power Engineering Company (KOPEC) on a US Department of Energy (DOE) sponsored Nuclear Energy Research Initiative (NERI) project through a collaborative agreement established for the domestic NERI program. The project deals with Risk-Informed Assessment (RIA) of regulatory and design requirements of future nuclear power plants. An objective of the RIA project is to develop a risk-informed design process, which focuses on identifying and incorporating advanced features into future nuclear power plants (NPPs) that would meet risk goals in a cost-effective manner. The RIA design methodology is proposed to accomplish this objective. This paper discusses the development of this methodology and demonstrates its application in the design of plant systems for future NPPs. Advanced conceptual plant systems consisting of an advanced Emergency Core Cooling System (ECCS) and Emergency Feedwater System (EFWS) for a NPP were developed and the risk-informed design process was exercised to demonstrate the viability and feasibility of the RIA design methodology. Best estimate Loss-of-Coolant Accident (LOCA) analyses were performed to validate the PSA success criteria for the NPP. The results of the analyses show that the PSA success criteria can be met using the advanced conceptual systems and that the RIA design methodology is a viable and appropriate means of designing key features of risk-significant NPP systems. (authors)

  20. 14 CFR Appendix A to Part 417 - Flight Safety Analysis Methodologies and Products for a Launch Vehicle Flown With a Flight Safety...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Flight Safety Analysis Methodologies and Products for a Launch Vehicle Flown With a Flight Safety System A Appendix A to Part 417 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Pt. 417, App....

  1. 14 CFR Appendix A to Part 417 - Flight Safety Analysis Methodologies and Products for a Launch Vehicle Flown With a Flight Safety...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Flight Safety Analysis Methodologies and Products for a Launch Vehicle Flown With a Flight Safety System A Appendix A to Part 417 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Pt. 417, App....

  2. 14 CFR Appendix A to Part 417 - Flight Safety Analysis Methodologies and Products for a Launch Vehicle Flown With a Flight Safety...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Flight Safety Analysis Methodologies and Products for a Launch Vehicle Flown With a Flight Safety System A Appendix A to Part 417 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Pt. 417, App....

  3. 14 CFR Appendix A to Part 417 - Flight Safety Analysis Methodologies and Products for a Launch Vehicle Flown With a Flight Safety...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Flight Safety Analysis Methodologies and Products for a Launch Vehicle Flown With a Flight Safety System A Appendix A to Part 417 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Pt. 417, App....

  4. A passive control methodology for seismic safety enhancement of monumental structures

    NASA Astrophysics Data System (ADS)

    Papalou, Angeliki; Roubien, Denis; Triantafillou, Thanasis; Strepelias, Elias

    2015-04-01

    A passive control methodology to increase the seismic safety of multi-drum columns is presented. The response of a large scale column-model to dynamic excitations is investigated experimentally. A particle damper is used to replace one of the columns' original drums. The influence of the system parameters on the response of the column is also examined. The seismic response of the column can be considerably reduced if a particle damper replaces a drum above the mid-height. Guidelines and a design methodology are proposed to restore and protect monumental structures consisting of multi-drum columns.

  5. Risk Assessment of Cascading Outages: Part I - Overview of Methodologies

    SciTech Connect

    Vaiman, Marianna; Bell, Keith; Chen, Yousu; Chowdhury, Badrul; Dobson, Ian; Hines, Paul; Papic, Milorad; Miller, Stephen; Zhang, Pei

    2011-07-31

    This paper is a result of ongoing activity carried out by Understanding, Prediction, Mitigation and Restoration of Cascading Failures Task Force under IEEE Computer Analytical Methods Subcommittee (CAMS). The task force's previous papers are focused on general aspects of cascading outages such as understanding, prediction, prevention and restoration from cascading failures. This is the first of two new papers, which will extend this previous work to summarize the state of the art in cascading failure risk analysis methodologies and modeling tools. This paper is intended to be a reference document to summarize the state of the art in the methodologies for performing risk assessment of cascading outages caused by some initiating event(s). A risk assessment should cover the entire potential chain of cascades starting with the initiating event(s) and ending with some final condition(s). However, this is a difficult task and heuristic approaches and approximations have been suggested. This paper discusses diffeent approaches to this and suggests directions for future development of methodologies.

  6. Methodology and Process for Condition Assessment at Existing Hydropower Plants

    SciTech Connect

    Zhang, Qin Fen; Smith, Brennan T; Cones, Marvin; March, Patrick; Dham, Rajesh; Spray, Michael

    2012-01-01

    Hydropower Advancement Project was initiated by the U.S. Department of Energy Office of Energy Efficiency and Renewable Energy to develop and implement a systematic process with a standard methodology to identify the opportunities of performance improvement at existing hydropower facilities and to predict and trend the overall condition and improvement opportunity within the U.S. hydropower fleet. The concept of performance for the HAP focuses on water use efficiency how well a plant or individual unit converts potential energy to electrical energy over a long-term averaging period of a year or more. The performance improvement involves not only optimization of plant dispatch and scheduling but also enhancement of efficiency and availability through advanced technology and asset upgrades, and thus requires inspection and condition assessment for equipment, control system, and other generating assets. This paper discusses the standard methodology and process for condition assessment of approximately 50 nationwide facilities, including sampling techniques to ensure valid expansion of the 50 assessment results to the entire hydropower fleet. The application and refining process and the results from three demonstration assessments are also presented in this paper.

  7. Renewable Energy Assessment Methodology for Japanese OCONUS Army Installations

    SciTech Connect

    Solana, Amy E.; Horner, Jacob A.; Russo, Bryan J.; Gorrissen, Willy J.; Kora, Angela R.; Weimar, Mark R.; Hand, James R.; Orrell, Alice C.; Williamson, Jennifer L.

    2010-08-30

    Since 2005, Pacific Northwest National Laboratory (PNNL) has been asked by Installation Management Command (IMCOM) to conduct strategic assessments at selected US Army installations of the potential use of renewable energy resources, including solar, wind, geothermal, biomass, waste, and ground source heat pumps (GSHPs). IMCOM has the same economic, security, and legal drivers to develop alternative, renewable energy resources overseas as it has for installations located in the US. The approach for continental US (CONUS) studies has been to use known, US-based renewable resource characterizations and information sources coupled with local, site-specific sources and interviews. However, the extent to which this sort of data might be available for outside the continental US (OCONUS) sites was unknown. An assessment at Camp Zama, Japan was completed as a trial to test the applicability of the CONUS methodology at OCONUS installations. It was found that, with some help from Camp Zama personnel in translating and locating a few Japanese sources, there was relatively little difficulty in finding sources that should provide a solid basis for conducting an assessment of comparable depth to those conducted for US installations. Project implementation will likely be more of a challenge, but the feasibility analysis will be able to use the same basic steps, with some adjusted inputs, as PNNL’s established renewable resource assessment methodology.

  8. New techniques for landslide hazard assessments: opportunities, methodology, and uncertainty

    NASA Astrophysics Data System (ADS)

    Kirschbaum, D. B.; Peters-Lidard, C. D.; Adler, R. F.; Hong, Y.

    2009-12-01

    An emerging global rainfall-triggered landslide hazard algorithm employs an empirical framework to identify potentially susceptible areas to rainfall-triggered landslides in near real-time. This methodology couples a satellite-derived estimate of cumulative rainfall with a static surface susceptibility map to highlight regions of anticipated landslide activity. While this algorithm represents an important first step in developing a larger-scale landslide prediction framework, there are many uncertainties and assumptions surrounding such a methodology that decreases the functionality and utility of this system. This research seeks to improve upon this initial concept by exploring the potential opportunities and methodological structure needed to advance larger-scale landslide hazard forecasting and make it more of an operational reality. Sensitivity analysis of the surface and rainfall parameters in the preliminary algorithm indicates that surface data resolution and the interdependency of variables must be more appropriately quantified at local and regional scales. Additionally, integrating available surface parameters must be approached in a more theoretical, physically-based manner to better represent the physical processes underlying slope instability and landslide initiation. Several rainfall infiltration and hydrological flow models have been developed to model slope instability at small spatial scales. This research investigates the potential of upscaling a more quantitative hydrological model to larger spatial scales, utilizing satellite and surface data inputs that are obtainable over different geographic regions. Due to the significant role that data and methodological uncertainties play in the effectiveness of landslide hazard assessment outputs, the methodology and data inputs are considered within an ensemble uncertainty framework in order to better resolve the contribution and limitations of model inputs and more effectively communicate the model skill.

  9. Methodological considerations when assessing restricted and repetitive behaviors and aggression

    PubMed Central

    Keefer, A.J.; Kalb, L.; Mazurek, M.O.; Kanne, S.M.; Freedman, B.; Vasa, R.A.

    2016-01-01

    Methodological issues impacting the relationship between aggression and restricted, repetitive, and stereotyped behaviors and interests (RRSBI) were examined in 2648 children and adolescents with autism spectrum disorders (ASD) using a multi-method, multi-informant analysis model to assess the effects of informant, assessment method, and aggression phenotype. Overall, a significant, but small relationship was found between RRSBI and aggression (p < .05). There was significant heterogeneity of estimates with large effect sizes observed when utilizing teacher report and a broad phenotype of aggression. Variance in estimates was attributed to differences in informant and assessment method with two times greater effect attributed to informant. Results suggest strategies to optimize future investigations of the relationship between RRSBI and aggression. Findings also provide the opportunity for the development of targeted interventions for aggression in youth with ASD. PMID:27239223

  10. Assessment of a French scenario with the INPRO methodology

    SciTech Connect

    Vasile, A.; Fiorini, G.L.; Cazalet, J.; Linet, F.L.; Moulin, V.; Greneche, D.

    2006-07-01

    This paper presents the French contribution to the Joint Study of the IAEA International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). It concerns the application of the INPRO methodology to a French scenario, on the transition from present LWRs to EPRs in a first phase and to 4. generation fast reactors in a second phase during the 21. century. The scenario also considers the renewal of the present fuel cycle facilities by the third and the fourth generation ones. Present practice of plutonium recycling in PWR is replaced by the middle of the century by a global recycling of actinides, uranium, plutonium and minor actinides in fast reactors. The status and the evolution of the INPRO criteria and the corresponding indicators during the studied period are analyzed for each of the six considered areas: economics, safety, environment, waste management, proliferation resistance and infrastructure. Improvements on economic and safety are expected for both the EPR and the 4. generation systems having these improvements among their basic goals. The use of fast reactors and global recycling of actinides leads to a significant improvement on environment indicators and in particular on the natural resources utilization. The envisaged waste management policy results in significant reductions on mass, thermal loads and radiotoxicity of the final waste which only contains fission products. The use of fuels that do not relay on enriched uranium and separated plutonium increases the proliferation resistance characteristics of the future fuel cycle. The paper summarizes also some recommendations on the data, codes and methods used to support the continuous improvement of the INPRO methodology and help future assessors. (authors)

  11. QTc prolongation assessment in anticancer drug development: clinical and methodological issues

    PubMed Central

    Curigliano, G; Spitaleri, G; de Braud, F; Cardinale, D; Cipolla, C; Civelli, M; Colombo, N; Colombo, A; Locatelli, M; Goldhirsch, A

    2009-01-01

    Cardiac safety assessments are commonly employed in the clinical development of investigational oncology medications. In anti-cancer drug development there has been increasing consideration for the potential of a compound to cause adverse electrocardiographic changes, especially QT interval prolongation, which can be associated with risk of torsades de pointes and sudden death. Irrespective of overt clinical toxicities, QTc assessment can potentially influence decision making at many levels during the conduct of clinical studies, including eligibility for protocol therapy, dose delivery or discontinuation, and analyses of optimal dose for subsequent development. Given the potential for serious and irreversible morbidity from cardiac adverse events, it is understandable that cardiac safety results can have broad impact on study conduct and patient management. The methodologies for risk management of QTc prolongation for non cardiac drugs have been developed out of experiences primarily from drugs used to treat non life-threatening illnesses in a chronic setting such as antibiotics or antihistamines. Extrapolating these approaches to drugs for treating cancer over an acute period may not be appropriate. Few specific guidelines are available for risk management of cardiac safety in the development and use of oncology drugs. In this manuscript, clinical and methodological issues related to QTc prolongation assessment will be reviewed. Discussions about limitations in phase-I design and oncology drug development will be highlighted. Efforts are needed to refine strategies for risk management, avoiding unintended consequences that negatively affect patient access and clinical development of promising new cancer treatments. A thoughtful risk management plan generated by an organized collaboration between oncologists, cardiologists, and regulatory agencies to support a development programme essential for oncology agents with cardiac safety concerns. PMID:22275999

  12. Safety Assessment of Multi Purpose Small Payload Rack(MSPR)

    NASA Astrophysics Data System (ADS)

    Mizutani, Yoshinobu; Takada, Satomi; Murata, Kosei; Ozawa, Daisaku; Kobayashi, Ryoji; Nakamura, Yasuhiro

    2010-09-01

    We are reporting summary of preliminary safety assessment for Multi Purpose Small Payload Rack(MSPR), which is one of the micro gravity experiment facilities that are being developed for the 2nd phase JEM utilization(JEM: Japanese Experiment Module) that will be launched on H-II Transfer Vehicle(HTV) 2nd flight in 2011. MSPR is used for multi-purpose micro-g experiment providing experimental spaces and work stations. MSPR has three experimental spaces; first, there is a space called Work Volume(WV) with capacity volume of approximately 350 litters, in which multiple resources including electricity, communication, and moving image functions can be used. Within this space, installation of devices can be done by simple, prompt attachment by Velcro and pins with high degree of flexibility. Second, there is Small Experiment Area(SEA), with capacity volume of approximately 70 litters, in which electricity, communication, and moving image functions can also be used in the same way as WV. These spaces protect experiment devices and specimens from contingent loads by the crewmembers. Third, there is Work Bench with area of 0.5 square meters, on which can be used for maintenance, inspection and data operations of installed devices, etc. This bench can be stored in the rack during contingency. Chamber for Combustion Experiment(CCE) that is planned to be installed in WV is a pressure-resistant experimental container that can be used to seal hazardous materials from combustion experiments. This CCE has double sealing design in chamber itself, which resist gas leakage under normal the temperature and pressure. Electricity, communication, moving image function can be used in the same way as WV. JAXA Phase 2 Safety Review Panel(SRP) has been held in April, 2010. For safety analysis of MSPR, hazards were identified based on Fault Tree Analysis methodology and then these hazards were classified into either eight ISS standard-type hazards or eight unique-type hazards that requires

  13. A Methodology to Assess Ionospheric Models for GNSS

    NASA Astrophysics Data System (ADS)

    Rovira-Garcia, Adria; Juan, José Miguel; Sanz, Jaume; González-Casado, Guillermo; Ibánez, Deimos

    2015-04-01

    Testing the accuracy of the ionospheric models used in the Global Navigation Satellite System (GNSS) is a long-standing issue. It is still a challenging problem due to the lack of accurate enough slant ionospheric determinations to be used as a reference. The present study proposes a methodology to assess any ionospheric model used in satellite-based applications and, in particular, GNSS ionospheric models. The methodology complements other analysis comparing the navigation based on different models to correct the code and carrier-phase observations. Specifically, the following ionospheric models are assessed: the operational models broadcast in the Global Positioning System (GPS), Galileo and the European Geostationary Navigation Overlay System (EGNOS), the post-process Global Ionospheric Maps (GIMs) from different analysis centers belonging to the International GNSS Service (IGS) and, finally, a new GIM computed by the gAGE/UPC research group. The methodology is based in the comparison between the predictions of the ionospheric model with actual unambiguous carrier-phase measurements from a global distribution of permanent receivers. The differences shall be separated into the hardware delays (a receiver constant plus a satellite constant) per data interval, e.g., a day. The condition that these Differential Code Biases (DCBs) are commonly shared throughout the world-wide network of receivers and satellites provides a global character to the assessment. This approach generalizes simple tests based on double differenced Slant Total Electron Contents (STECs) between pairs of satellites and receivers on a much local scale. The present study has been conducted during the entire 2014, i.e., the last Solar Maximum. The seasonal and latitudinal structures of the results clearly reflect the different strategies used by the different models. On one hand, ionospheric model corrections based on a grid (IGS-GIMs or EGNOS) are shown to be several times better than the models

  14. Assessing Hmong farmers' safety and health.

    PubMed

    de Castro, A B; Krenz, Jennifer; Neitzel, Richard L

    2014-05-01

    This pilot project investigated agricultural-related safety and health issues among Hmong refugees working on family-operated farms. Novel approaches, namely participatory rural appraisal and photovoice, were used to conduct a qualitative occupational hazard assessment with a group of Hmong farmers in Washington State. These two methods were useful in gathering participants' own perspectives about priority concerns. Several identified problems were related to musculoskeletal disorders, handling and operating heavy machinery, heat and cold stress, respiratory exposures, pest management, and socioeconomic and language concerns. Findings from this study provide insight into the work-related challenges that Hmong refugee farmers encounter and can serve as a basis for occupational health professionals to develop interventions to assist this underserved group. PMID:24806037

  15. Assessing Hmong Farmers’ Safety and Health

    PubMed Central

    de Castro, A. B.; Krenz, Jennifer; Neitzel, Richard L.

    2014-01-01

    This pilot project investigated agricultural-related safety and health issues among Hmong refugees working on family-operated farms. Novel approaches, namely participatory rural appraisal and photovoice, were used to conduct a qualitative occupational hazard assessment with a group of Hmong farmers in Washington State. These two methods were useful in gathering participants’ own perspectives about priority concerns. Several identified problems were related to musculoskeletal disorders, handling and operating heavy machinery, heat and cold stress, respiratory exposures, pest management, and socioeconomic and language concerns. Findings from this study provide insight into the work-related challenges that Hmong refugee farmers encounter and can serve as a basis for occupational health professionals to develop interventions to assist this underserved group. PMID:24806037

  16. Application of Non-Human Biota Assessment Methodologies to the Assessment of Potential Impacts from a Nuclear Waste Repository

    SciTech Connect

    Smith, K.L.; Robinson, C.A.; Ikonen, A.T.K.

    2007-07-01

    The protection of the environment from the effects of ionising radiation has become increasingly more topical over the last few years as the intentions enshrined in international principles and agreements have become more binding through national and international law. For example, the Directive on impact of certain projects on the environment (EIA Directive 85/337/EEC) [CEC, 1985], amended in 1997 [CEC, 1997], places a mandatory requirement on all EU Member States to conduct environmental impact assessments for a range of project having potential impact on the environment, including radioactive waste disposal. Such assessments must consider humans, fauna and flora, the abiotic environment (soil, water, air), material assets and cultural heritage as well as the interactions between these factors. In Finland, Posiva Oy are responsible for the overall repository programme for spent nuclear fuel and, as such, are conducting the Safety Case Assessment for a proposed geological repository for nuclear waste. Within the European legislation framework, the Finnish regulatory body requires that the repository safety case assessment should include not only human radiological safety, but also an assessment of the potential impact upon populations of non-human biota. Specifically, the Safety Case should demonstrate that there will be: - no decline in the biodiversity of currently living populations; - no significant detriment to populations of fauna and flora; and, - no detrimental effects on individuals of domestic animals and rare plants and animals. At present, there are no internationally agreed criteria that explicitly address protection of the environment from ionising radiation. However, over recent years a number of assessment methodologies have been developed including, at a European level, the Framework for the Assessment of Environmental impact (FASSET) and Environmental Risks from Ionising Contaminants (ERICA). The International Committee on Radiation Protection

  17. Environmental Restoration Disposal Facility (Project W-296) Safety Assessment

    SciTech Connect

    Armstrong, D.L.

    1994-08-01

    This Safety Assessment is based on information derived from the Conceptual Design Report for the Environmental Restoration Disposal Facility (DOE/RL 1994) and ancillary documentation developed during the conceptual design phase of Project W-296. The Safety Assessment has been prepared to support the Solid Waste Burial Ground Interim Safety Basis document. The purpose of the Safety Assessment is to provide an evaluation of the design to determine if the process, as proposed, will comply with US Department of Energy (DOE) Limits for radioactive and hazardous material exposures and be acceptable from an overall health and safety standpoint. The evaluation considered affects on the worker, onsite personnel, the public, and the environment.

  18. Development of risk assessment methodology for municipal sludge incineration

    SciTech Connect

    Not Available

    1990-10-01

    This is one of a series of reports that present methodologies for assessing the potential risks to humans or other organisms from the disposal or reuse of municipal sludge. The sludge management practices addressed by the series include land application practices, distribution and marketing programs, landfilling, surface disposal, incineration and ocean disposal. In particular, these reports provide methods for evaluating potential health and environmental risks from toxic chemicals that may be present in sludge. The document addresses risks from chemicals associated with incineration of municipal sludge. These proposed risk assessment procedures are designed as tools to assist in the development of regulations for sludge management practices. The procedures are structured to allow calculation of technical criteria for sludge disposal/reuse options based on the potential for adverse health or environmental impacts. The criteria may address management practices (such as site design or process control specifications), limits on sludge disposal rates or limits on toxic chemical concentrations in the sludge.

  19. A Methodology for Robust Comparative Life Cycle Assessments Incorporating Uncertainty.

    PubMed

    Gregory, Jeremy R; Noshadravan, Arash; Olivetti, Elsa A; Kirchain, Randolph E

    2016-06-21

    We propose a methodology for conducting robust comparative life cycle assessments (LCA) by leveraging uncertainty. The method evaluates a broad range of the possible scenario space in a probabilistic fashion while simultaneously considering uncertainty in input data. The method is intended to ascertain which scenarios have a definitive environmentally preferable choice among the alternatives being compared and the significance of the differences given uncertainty in the parameters, which parameters have the most influence on this difference, and how we can identify the resolvable scenarios (where one alternative in the comparison has a clearly lower environmental impact). This is accomplished via an aggregated probabilistic scenario-aware analysis, followed by an assessment of which scenarios have resolvable alternatives. Decision-tree partitioning algorithms are used to isolate meaningful scenario groups. In instances where the alternatives cannot be resolved for scenarios of interest, influential parameters are identified using sensitivity analysis. If those parameters can be refined, the process can be iterated using the refined parameters. We also present definitions of uncertainty quantities that have not been applied in the field of LCA and approaches for characterizing uncertainty in those quantities. We then demonstrate the methodology through a case study of pavements. PMID:27219285

  20. Characterization and improvement of the nuclear safety culture through self-assessment

    SciTech Connect

    Levin, H.A.; McGehee, R.B.; Cottle, W.T.

    1996-12-31

    Organizational culture has a powerful influence on overall corporate performance. The ability to sustain superior results in ensuring the public`s health and safety is predicated on an organization`s deeply embedded values and behavioral norms and how these affect the ability to change and seek continuous improvement. The nuclear industry is developing increased recognition of the relationship of culture to nuclear safety performance as a critical element of corporate strategy. This paper describes a self-assessment methodology designed to characterize and improve the nuclear safety culture, including processes for addressing employee concerns. This methodology has been successfully applied on more than 30 occasions in the last several years, resulting in measurable improvements in safety performance and quality and employee motivation, productivity, and morale. Benefits and lessons learned are also presented.

  1. Track train dynamics analysis and test program: Methodology development for the derailment safety analysis of six-axle locomotives

    NASA Technical Reports Server (NTRS)

    Marcotte, P. P.; Mathewson, K. J. R.

    1982-01-01

    The operational safety of six axle locomotives is analyzed. A locomotive model with corresponding data on suspension characteristics, a method of track defect characterization, and a method of characterizing operational safety are used. A user oriented software package was developed as part of the methodology and was used to study the effect (on operational safety) of various locomotive parameters and operational conditions such as speed, tractive effort, and track curvature. The operational safety of three different locomotive designs was investigated.

  2. Safety assessment of discharge chute isolation barrier preparation and installation

    SciTech Connect

    Meichle, R.H.

    1994-09-29

    The safety assessment is made for the activities for the preparation and installation of the discharge chute isolation barriers. The safety assessment includes a hazard assessment and comparison of potential accidents/events to those addressed by the current safety basis documentation. No significant hazards were identified. An evaluation against the USQ evaluation questions were made and the determination made that the activities do not represent a USQ. Hazard categorization techniques were used to provide a basis for readiness review classification.

  3. Methodology, status and plans for development and assessment of Cathare code

    SciTech Connect

    Bestion, D.; Barre, F.; Faydide, B.

    1997-07-01

    This paper presents the methodology, status and plans for the development, assessment and uncertainty evaluation of the Cathare code. Cathare is a thermalhydraulic code developed by CEA (DRN), IPSN, EDF and FRAMATOME for PWR safety analysis. First, the status of the code development and assessment is presented. The general strategy used for the development and the assessment of the code is presented. Analytical experiments with separate effect tests, and component tests are used for the development and the validation of closure laws. Successive Revisions of constitutive laws are implemented in successive Versions of the code and assessed. System tests or integral tests are used to validate the general consistency of the Revision. Each delivery of a code Version + Revision is fully assessed and documented. A methodology is being developed to determine the uncertainty on all constitutive laws of the code using calculations of many analytical tests and applying the Discrete Adjoint Sensitivity Method (DASM). At last, the plans for the future developments of the code are presented. They concern the optimization of the code performance through parallel computing - the code will be used for real time full scope plant simulators - the coupling with many other codes (neutronic codes, severe accident codes), the application of the code for containment thermalhydraulics. Also, physical improvements are required in the field of low pressure transients and in the modeling for the 3-D model.

  4. 77 FR 26292 - Risk Evaluation and Mitigation Strategy Assessments: Social Science Methodologies to Assess Goals...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-03

    ...The Food and Drug Administration (FDA) is announcing a public workshop entitled ``Risk Evaluation and Mitigation Strategy Assessments: Social Science Methodologies to Assess Goals Related to Knowledge.'' The purpose of the public workshop is to initiate constructive dialogue and information-sharing among regulators, researchers, the pharmaceutical industry, health care organizations, health......

  5. Constantly evolving safety assessment protocols for GM foods.

    PubMed

    Sesikeran, B; Vasanthi, Siruguri

    2008-01-01

    he introduction of GM foods has led to the evolution of a food safety assessment paradigm that establishes safety of the GM food relative to its conventional counterpart. The GM foods currently approved and marketed in several countries have undergone extensive safety testing under a structured safety assessment framework evolved by international organizations like FAO, WHO, Codex and OECD. The major elements of safety assessment include molecular characterization of inserted genes and stability of the trait, toxicity and allergenicity potential of the expressed substances, compositional analysis, potential for gene transfer to gut microflora and unintentional effects of the genetic modification. As more number and type of food crops are being brought under the genetic modification regime, the adequacy of existing safety assessment protocols for establishing safety of these foods has been questioned. Such crops comprise GM crops with higher agronomic vigour, nutritional or health benefit/ by modification of plant metabolic pathways and those expressing bioactive substances and pharmaceuticals. The safety assessment challenges of these foods are the potential of the methods to detect unintentional effects with higher sensitivity and rigor. Development of databases on food compositions, toxicants and allergens is currently seen as an important aid to development of safety protocols. With the changing global trends in genetic modification technology future challenge would be to develop GM crops with minimum amount of inserted foreign DNA so as to reduce the burden of complex safety assessments while ensuring safety and utility of the technology. PMID:18296346

  6. An ABET assessment model using Six Sigma methodology

    NASA Astrophysics Data System (ADS)

    Lalovic, Mira

    Technical fields are changing so rapidly that even the core of an engineering education must be constantly reevaluated. Graduates of today give more dedication and, almost certainly, more importance to continued learning than to mastery of specific technical concepts. Continued learning shapes a high-quality education, which is what an engineering college must offer its students. The question is how to guarantee the quality of education. In addition, the Accreditation Board of Engineering and Technology is asking that universities commit to continuous and comprehensive education, assuming quality of the educational process. The research is focused on developing a generic assessment model for a college of engineering as an annual cycle that consists of a systematic assessment of every course in the program, followed by an assessment of the program and of the college as a whole using Six Sigma methodology. This unique approach to assessment in education will provide a college of engineering with valuable information regarding many important curriculum decisions in every accreditation cycle. The Industrial and Manufacturing Engineering (IME) Program in the College of Engineering at the University of Cincinnati will be used as a case example for a preliminary test of the generic model.

  7. Methodology for the environmental assessment of advanced coal extraction systems

    SciTech Connect

    Sullivan, P.J.; Hutchinson, C.F.; Makihara, J.; Evensizer, J.

    1980-06-15

    This document describes the methodology which was developed to identify and assess potential environmental impacts of advanced mining technology as it moves from a generic concept to a more precise systems definition. Two levels of assessment are defined in terms of the design stage of the technology being evaluated. The first level of analysis is appropriate to a conceptual design. At this level it is assumed that each mining process has known and potential environmental impacts that are generic to each mining activity. By using this assumption, potential environmental impacts can be identified for new mining systems. When two or more systems have been assessed, they can be evaluated by comparing potential environmental impacts. At the preliminary stage of design, a systems performance can be assessed again with more precision. At this level of systems definition, potential environmental impacts can be analyzed and their significance determined in a manner to facilitate comparisons between systems. An important output of each level of analysis is suggestions calculated to help the designer mitigate potentially harmful impacts.

  8. Risk assessment methodologies for passive smoking-induced lung cancer

    SciTech Connect

    Repace, J.L.; Lowrey, A.H. )

    1990-03-01

    Risk assessment methodologies have been successfully applied to control societal risk from outdoor air pollutants. They are now being applied to indoor air pollutants such as environmental tobacco smoke (ETS) and radon. Nonsmokers' exposures to ETS have been assessed based on dosimetry of nicotine, its metabolite, continine, and on exposure to the particulate phase of ETS. Lung cancer responses have been based on both the epidemiology of active and of passive smoking. Nine risk assessments of nonsmokers' lung cancer risk from exposure to ETS have been performed. Some have estimated risks for lifelong nonsmokers only; others have included ex-smokers; still others have estimated total deaths from all causes. To facilitate interstudy comparison, in some cases lung cancers had to be interpolated from a total, or the authors' original estimate had to be adjusted to include ex-smokers. Further, all estimates were adjusted to 1988. Excluding one study whose estimate differs from the mean of the others by two orders of magnitude, the remaining risk assessments are in remarkable agreement. The mean estimate is approximately 5000 +/- 2400 nonsmokers' lung cancer deaths (LCDSs) per year. This is a 25% greater risk to nonsmokers than is indoor radon, and is about 57 times greater than the combined estimated cancer risk from all the hazardous outdoor air pollutants currently regulated by the Environmental Protection Agency: airborne radionuclides, asbestos, arsenic, benzene, coke oven emissions, and vinyl chloride. 48 references.

  9. Methodology for qualitative uncertainty assessment of climate impact indicators

    NASA Astrophysics Data System (ADS)

    Otto, Juliane; Keup-Thiel, Elke; Rechid, Diana; Hänsler, Andreas; Pfeifer, Susanne; Roth, Ellinor; Jacob, Daniela

    2016-04-01

    The FP7 project "Climate Information Portal for Copernicus" (CLIPC) is developing an integrated platform of climate data services to provide a single point of access for authoritative scientific information on climate change and climate change impacts. In this project, the Climate Service Center Germany (GERICS) has been in charge of the development of a methodology on how to assess the uncertainties related to climate impact indicators. Existing climate data portals mainly treat the uncertainties in two ways: Either they provide generic guidance and/or express with statistical measures the quantifiable fraction of the uncertainty. However, none of the climate data portals give the users a qualitative guidance how confident they can be in the validity of the displayed data. The need for such guidance was identified in CLIPC user consultations. Therefore, we aim to provide an uncertainty assessment that provides the users with climate impact indicator-specific guidance on the degree to which they can trust the outcome. We will present an approach that provides information on the importance of different sources of uncertainties associated with a specific climate impact indicator and how these sources affect the overall 'degree of confidence' of this respective indicator. To meet users requirements in the effective communication of uncertainties, their feedback has been involved during the development process of the methodology. Assessing and visualising the quantitative component of uncertainty is part of the qualitative guidance. As visual analysis method, we apply the Climate Signal Maps (Pfeifer et al. 2015), which highlight only those areas with robust climate change signals. Here, robustness is defined as a combination of model agreement and the significance of the individual model projections. Reference Pfeifer, S., Bülow, K., Gobiet, A., Hänsler, A., Mudelsee, M., Otto, J., Rechid, D., Teichmann, C. and Jacob, D.: Robustness of Ensemble Climate Projections

  10. Global scale flood exposure assessment - Methodologies and results

    NASA Astrophysics Data System (ADS)

    Jongman, B.; Ward, P. J.; Aerts, J. C. J. H.

    2012-04-01

    Flood damage modelling has traditionally been limited to the local, regional or national scale. Recent flood events, population growth and climate change concerns have increased the need for global methods with both spatial and temporal dynamics. In this study we present a first estimate of economic exposure to both river and coastal flooding on a global scale from 1970 - 2050, using two different methods for economic exposure calculation. One methodology is based on population densities and GDP, while the other method uses land-use and maximum damage figures to calculate economic exposure. Both methods show very similar upward trends in economic exposure over the period 1970-2050. However, the absolute exposure values resulting from the two methods show different magnitudes, reflecting variation in urbanisation and income. Furthermore we found that growth of population and economic assets in flood prone areas is higher than average national growth, especially in developing countries. As a next step, we propose a methodology for assessing total flood vulnerability that goes beyond economic impact, using a welfare-based approach based on a broad range of development indicators. The results are interesting for academics and practitioners working on international environmental, economic and development issues at the regional and global scales.

  11. A methodology for assessing high intensity RF effects in aircraft

    SciTech Connect

    Zacharias, R.A.; Avalle, C.A.; Kunz, K.S.; Molau, N.E.; Pennock, S.T.; Poggio, A.J.; Sharpe, R.M.

    1993-07-01

    Optical components have an inherent immunity to the electromagnetic interference (EMI) associated with High Intensity Radiated Fields (HIRF). The optical technology embodied in Fly-by-Light (FBL) might therefore minimize the effects of HIRF on digitally controlled systems while providing lifetime immunity to signal EMI. This is one of the primary motivations for developing FBL systems for aircraft. FBL has the potential to greatly simplify EMI certification by enabling technically acceptable laboratory tests of subsystems, as opposed to expensive full airplane tests. In this paper the authors describe a methodology for assessing EMI effects on FBL aircraft that reduces or potentially eliminates the need for full airplane tests. This methodology is based on comparing the applied EMI stress--the level of interference signal that arrives at a unit under test--versus the EMI strength of the unit--the interference level it can withstand without upset. This approach allows one to use computer models and/or low power coupling measurement and similarity (to other previously tested aircraft) to determine the stress applied to installed subsystems, and to use benchtop cable injection tests and/or mode stirred chamber radiated tests to determine the strength of the subsystem.

  12. Assessment of capillary suction time (CST) test methodologies.

    PubMed

    Sawalha, O; Scholz, M

    2007-12-01

    The capillary suction time (CST) test is a commonly used method to measure the filterability and the easiness of removing moisture from slurry and sludge in numerous environmental and industrial applications. This study assessed several novel alterations of both the test methodology and the current standard capillary suction time (CST) apparatus. Twelve different papers including the standard Whatman No. 17 chromatographic paper were tested. The tests were run using four different types of sludge including a synthetic sludge, which was specifically developed for benchmarking purposes. The standard apparatus was altered by the introduction of a novel rectangular funnel instead of a standard circular one. A stirrer was also introduced to solve the problem of test inconsistency (e.g. high CST variability) particularly for heavy types of sludge. Results showed that several alternative papers, which are cheaper than the standard paper, can be used to estimate CST values accurately, and that the test repeatability can be improved in many cases and for different types of sludge. The introduction of the rectangular funnel demonstrated an obvious enhancement of test repeatability. The use of a stirrer to avoid sedimentation of heavy sludge did not have statistically significant impact on the CST values or the corresponding data variability. The application of synthetic sludge can support the testing of experimental methodologies and should be used for subsequent benchmarking purposes. PMID:18341148

  13. Handbook of five methodologies for the assessment of load management

    SciTech Connect

    Not Available

    1980-02-01

    This report provides a summary description and evaluation of five methodologies that have been developed for the assessment of utility costs and benefits of load-management programs, including marginal-costing methodologies and an integrated set of utility-system planning and production costing models. Of the two basic methods, the first uses marginal-cost data to compute the cumulative reduction in utility-system costs realized in moving units of load from periods of high marginal cost to periods of low marginal cost. The present value of these cost savings may be compared directly with the costs of implementing the load-management program. The second method relies on an evaluation of future total-system costs. System planning and production-costing models are used to calculate the total fixed and variable costs of meeting baseline and alternative-load configurations. The difference between baseline system costs and the costs with load management may then be compared to the costs of implementing the program. The advantages and disadvantages of each method are summarized briefly.

  14. Integrated deterministic and probabilistic safety analysis for safety assessment of nuclear power plants

    DOE PAGESBeta

    Di Maio, Francesco; Zio, Enrico; Smith, Curtis; Rychkov, Valentin

    2015-07-06

    The present special issue contains an overview of the research in the field of Integrated Deterministic and Probabilistic Safety Assessment (IDPSA) of Nuclear Power Plants (NPPs). Traditionally, safety regulation for NPPs design and operation has been based on Deterministic Safety Assessment (DSA) methods to verify criteria that assure plant safety in a number of postulated Design Basis Accident (DBA) scenarios. Referring to such criteria, it is also possible to identify those plant Structures, Systems, and Components (SSCs) and activities that are most important for safety within those postulated scenarios. Then, the design, operation, and maintenance of these “safety-related” SSCs andmore » activities are controlled through regulatory requirements and supported by Probabilistic Safety Assessment (PSA).« less

  15. Integrated deterministic and probabilistic safety analysis for safety assessment of nuclear power plants

    SciTech Connect

    Di Maio, Francesco; Zio, Enrico; Smith, Curtis; Rychkov, Valentin

    2015-07-06

    The present special issue contains an overview of the research in the field of Integrated Deterministic and Probabilistic Safety Assessment (IDPSA) of Nuclear Power Plants (NPPs). Traditionally, safety regulation for NPPs design and operation has been based on Deterministic Safety Assessment (DSA) methods to verify criteria that assure plant safety in a number of postulated Design Basis Accident (DBA) scenarios. Referring to such criteria, it is also possible to identify those plant Structures, Systems, and Components (SSCs) and activities that are most important for safety within those postulated scenarios. Then, the design, operation, and maintenance of these “safety-related” SSCs and activities are controlled through regulatory requirements and supported by Probabilistic Safety Assessment (PSA).

  16. Practical Methodology of Cognitive Tasks Within a Navigational Assessment

    PubMed Central

    Robillard, Manon; Mayer-Crittenden, Chantal; Roy-Charland, Annie; Minor-Corriveau, Michèle; Bélanger, Roxanne

    2015-01-01

    This paper describes an approach for measuring navigation accuracy relative to cognitive skills. The methodology behind the assessment will thus be clearly outlined in a step-by-step manner. Navigational skills are important when trying to find symbols within a speech-generating device (SGD) that has a dynamic screen and taxonomical organization. The following skills have been found to impact children’s ability to find symbols when navigating within the levels of an SGD: sustained attention, categorization, cognitive flexibility, and fluid reasoning1,2. According to past studies, working memory was not correlated with navigation1,2. The materials needed for this method include a computerized tablet, an augmentative and alternative communication application, a booklet of symbols, and the Leiter International Performance Scale-Revised (Leiter-R)3. This method has been used in two previous studies. Robillard, Mayer-Crittenden, Roy-Charland, Minor-Corriveau and Bélanger1 assessed typically developing children, while Rondeau, Robillard and Roy-Charland2 assessed children and adolescents with a diagnosis of Autism Spectrum Disorder. The direct observation of this method will facilitate the replication of this study for researchers. It will also help clinicians that work with children who have complex communication needs to determine the children’s ability to navigate an SGD with taxonomical categorization. PMID:26065431

  17. Optical methodology for the health assessment of power transformers

    NASA Astrophysics Data System (ADS)

    Palmer, John A.; Wang, Xianghui; Shoureshi, Rahmat A.; Mander, Arthur A.; Torgerson, Duane

    2000-06-01

    Among the most critical components in the electric power system is the power transformer. As such, a significant body of research has been put forward to attempt to anticipate the needs for maintenance to be performed. Traditional health assessment has required sampling of oil for submission to a laboratory for analysis, but this has been deemed undesirable in light of budgetary constraints on maintenance staffing, and new predictive maintenance philosophies for substation equipment. A number of processes have been developed in recent years for online health assessment of transformers, most of which have focused on dissolved gas analysis. This paper describes a novel optical methodology for on-line transformer health assessment that utilizes an ultraviolet absorption measurement to identify the degradation of the transformer oil. An optical system was selected because of its immunity to the electromagnetic noise typical of substations, and because of the minimal impact that non-conducting materials have on the insulation system design of the transformer. The system is designed to identify deterioration and premature aging resulting from overheating, low level arcing or excessive exposure to atmospheric air. The system consists of a light source, filter, guide and detection components, and a very simple computational requirement. The measurements performed with the prototype system are validated with a high precision spectrophotometry measurement and an independent oil-testing laboratory.

  18. A novel integrated assessment methodology of urban water reuse.

    PubMed

    Listowski, A; Ngo, H H; Guo, W S; Vigneswaran, S

    2011-01-01

    Wastewater is no longer considered a waste product and water reuse needs to play a stronger part in securing urban water supply. Although treatment technologies for water reclamation have significantly improved the question that deserves further analysis is, how selection of a particular wastewater treatment technology relates to performance and sustainability? The proposed assessment model integrates; (i) technology, characterised by selected quantity and quality performance parameters; (ii) productivity, efficiency and reliability criteria; (iii) quantitative performance indicators; (iv) development of evaluation model. The challenges related to hierarchy and selections of performance indicators have been resolved through the case study analysis. The goal of this study is to validate a new assessment methodology in relation to performance of the microfiltration (MF) technology, a key element of the treatment process. Specific performance data and measurements were obtained at specific Control and Data Acquisition Points (CP) to satisfy the input-output inventory in relation to water resources, products, material flows, energy requirements, chemicals use, etc. Performance assessment process contains analysis and necessary linking across important parametric functions leading to reliable outcomes and results. PMID:22335107

  19. Q methodology: a new way of assessing employee satisfaction.

    PubMed

    Chinnis, A S; Summers, D E; Doerr, C; Paulson, D J; Davis, S M

    2001-05-01

    As yet another nursing shortage faces the country, the issue of the satisfaction of nurses again becomes of critical concern to nursing managers in the interest of staff retention. The authors describe the use of the statistical technique Q methodology to assess the needs of nurses and other medical staff at a level one, tertiary care emergency department in the United States. Using the Q method, the authors were able to identify different, unique viewpoints concerning employee needs among the study population, as well as commonly shared views. This level of detail, not obtainable using more traditional statistical techniques, can aid in the design of more effective strategies aimed at fulfilling the needs of an organization's staff to increase their satisfaction. PMID:11388161

  20. Life-cycle assessment (LCA) methodology applied to energetic materials

    SciTech Connect

    Reardon, P.T.

    1995-03-01

    The objective of the Clean Agile Manufacturing of Propellants, Explosives, and pyrotechnics (CAMPEP) program is to develop and demonstrate the feasibility of using modeling, alternate materials and processing technology to reduce PEO life-cycle pollution by up to 90%. Traditional analyses of factory pollution treat the manufacturing facility as the singular pollution source. The life cycle of a product really begins with raw material acquisition and includes all activities through ultimate disposal. The life cycle thus includes other facilities besides the principal manufacturing facility. The pollution generated during the product life cycle is then integrated over the total product lifetime, or represents a ``cradle to grave`` accounting philosophy. This paper addresses a methodology for producing a life-cycle inventory assessment.

  1. A methodology for adaptable and robust ecosystem services assessment.

    PubMed

    Villa, Ferdinando; Bagstad, Kenneth J; Voigt, Brian; Johnson, Gary W; Portela, Rosimeiry; Honzák, Miroslav; Batker, David

    2014-01-01

    Ecosystem Services (ES) are an established conceptual framework for attributing value to the benefits that nature provides to humans. As the promise of robust ES-driven management is put to the test, shortcomings in our ability to accurately measure, map, and value ES have surfaced. On the research side, mainstream methods for ES assessment still fall short of addressing the complex, multi-scale biophysical and socioeconomic dynamics inherent in ES provision, flow, and use. On the practitioner side, application of methods remains onerous due to data and model parameterization requirements. Further, it is increasingly clear that the dominant "one model fits all" paradigm is often ill-suited to address the diversity of real-world management situations that exist across the broad spectrum of coupled human-natural systems. This article introduces an integrated ES modeling methodology, named ARIES (ARtificial Intelligence for Ecosystem Services), which aims to introduce improvements on these fronts. To improve conceptual detail and representation of ES dynamics, it adopts a uniform conceptualization of ES that gives equal emphasis to their production, flow and use by society, while keeping model complexity low enough to enable rapid and inexpensive assessment in many contexts and for multiple services. To improve fit to diverse application contexts, the methodology is assisted by model integration technologies that allow assembly of customized models from a growing model base. By using computer learning and reasoning, model structure may be specialized for each application context without requiring costly expertise. In this article we discuss the founding principles of ARIES--both its innovative aspects for ES science and as an example of a new strategy to support more accurate decision making in diverse application contexts. PMID:24625496

  2. Assessing patient preferences in heart failure using conjoint methodology

    PubMed Central

    Pisa, Giovanni; Eichmann, Florian; Hupfer, Stephan

    2015-01-01

    Aim The course of heart failure (HF) is characterized by frequent hospitalizations, a high mortality rate, as well as a severely impaired health-related quality of life (HRQoL). To optimize disease management, understanding of patient preferences is crucial. We aimed to assess patient preferences using conjoint methodology and HRQoL in patients with HF. Methods Two modules were applied: an initial qualitative module, consisting of in-depth interviews with 12 HF patients, and the main quantitative module in 300 HF patients from across Germany. Patients were stratified according to the time of their last HF hospitalization. Each patient was presented with ten different scenarios during the conjoint exercise. Additionally, patients completed the generic HRQoL instrument, EuroQol health questionnaire (EQ-5D™). Results The attribute with the highest relative importance was dyspnea (44%), followed by physical capacity (18%). Of similar importance were exhaustion during mental activities (13%), fear due to HF (13%), and autonomy (12%). The most affected HRQoL dimensions according to the EQ-5D questionnaire were anxiety/depression (23% with severe problems), pain/discomfort (19%), and usual activities (15%). Overall average EQ-5D score was 0.39 with stable, chronic patients (never hospitalized) having a significantly better health state vs the rest of the cohort. Conclusion This paper analyzed patient preference in HF using a conjoint methodology. The preference weights resulting from the conjoint analysis could be used in future to design HRQoL questionnaires which could better assess patient preferences in HF care. PMID:26345530

  3. A Methodology for Adaptable and Robust Ecosystem Services Assessment

    PubMed Central

    Villa, Ferdinando; Bagstad, Kenneth J.; Voigt, Brian; Johnson, Gary W.; Portela, Rosimeiry; Honzák, Miroslav; Batker, David

    2014-01-01

    Ecosystem Services (ES) are an established conceptual framework for attributing value to the benefits that nature provides to humans. As the promise of robust ES-driven management is put to the test, shortcomings in our ability to accurately measure, map, and value ES have surfaced. On the research side, mainstream methods for ES assessment still fall short of addressing the complex, multi-scale biophysical and socioeconomic dynamics inherent in ES provision, flow, and use. On the practitioner side, application of methods remains onerous due to data and model parameterization requirements. Further, it is increasingly clear that the dominant “one model fits all” paradigm is often ill-suited to address the diversity of real-world management situations that exist across the broad spectrum of coupled human-natural systems. This article introduces an integrated ES modeling methodology, named ARIES (ARtificial Intelligence for Ecosystem Services), which aims to introduce improvements on these fronts. To improve conceptual detail and representation of ES dynamics, it adopts a uniform conceptualization of ES that gives equal emphasis to their production, flow and use by society, while keeping model complexity low enough to enable rapid and inexpensive assessment in many contexts and for multiple services. To improve fit to diverse application contexts, the methodology is assisted by model integration technologies that allow assembly of customized models from a growing model base. By using computer learning and reasoning, model structure may be specialized for each application context without requiring costly expertise. In this article we discuss the founding principles of ARIES - both its innovative aspects for ES science and as an example of a new strategy to support more accurate decision making in diverse application contexts. PMID:24625496

  4. A methodology for adaptable and robust ecosystem services assessment

    USGS Publications Warehouse

    Villa, Ferdinando; Bagstad, Kenneth J.; Voigt, Brian; Johnson, Gary W.; Portela, Rosimeiry; Honzák, Miroslav; Batker, David

    2014-01-01

    Ecosystem Services (ES) are an established conceptual framework for attributing value to the benefits that nature provides to humans. As the promise of robust ES-driven management is put to the test, shortcomings in our ability to accurately measure, map, and value ES have surfaced. On the research side, mainstream methods for ES assessment still fall short of addressing the complex, multi-scale biophysical and socioeconomic dynamics inherent in ES provision, flow, and use. On the practitioner side, application of methods remains onerous due to data and model parameterization requirements. Further, it is increasingly clear that the dominant “one model fits all” paradigm is often ill-suited to address the diversity of real-world management situations that exist across the broad spectrum of coupled human-natural systems. This article introduces an integrated ES modeling methodology, named ARIES (ARtificial Intelligence for Ecosystem Services), which aims to introduce improvements on these fronts. To improve conceptual detail and representation of ES dynamics, it adopts a uniform conceptualization of ES that gives equal emphasis to their production, flow and use by society, while keeping model complexity low enough to enable rapid and inexpensive assessment in many contexts and for multiple services. To improve fit to diverse application contexts, the methodology is assisted by model integration technologies that allow assembly of customized models from a growing model base. By using computer learning and reasoning, model structure may be specialized for each application context without requiring costly expertise. In this article we discuss the founding principles of ARIES - both its innovative aspects for ES science and as an example of a new strategy to support more accurate decision making in diverse application contexts.

  5. Safety assessment and detection methods of genetically modified organisms.

    PubMed

    Xu, Rong; Zheng, Zhe; Jiao, Guanglian

    2014-01-01

    Genetically modified organisms (GMOs), are gaining importance in agriculture as well as the production of food and feed. Along with the development of GMOs, health and food safety concerns have been raised. These concerns for these new GMOs make it necessary to set up strict system on food safety assessment of GMOs. The food safety assessment of GMOs, current development status of safety and precise transgenic technologies and GMOs detection have been discussed in this review. The recent patents about GMOs and their detection methods are also reviewed. This review can provide elementary introduction on how to assess and detect GMOs. PMID:25342147

  6. Safety Assessment of Dialkyl Malates as Used in Cosmetics.

    PubMed

    Becker, Lillian C; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Andersen, F Alan

    2015-01-01

    The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of 6 dialkyl malate compounds used in cosmetics. These ingredients function mostly as skin-conditioning agents-emollients. The Panel reviewed relevant animal and human data related to the ingredients along with a previous safety assessment of malic acid. The similar structure, properties, functions, and uses of these ingredients enabled grouping them and using the available toxicological data to assess the safety of the entire group. The Panel concluded that these dialkyl maleate compounds are safe in the present practices of use and concentration as given in this safety assessment. PMID:26227891

  7. Determining a cost/effectiveness/safety tradeoff methodology for strategic nuclear warheads

    SciTech Connect

    Erickson, S.A. Jr.; Hall, C.H.

    1992-04-27

    Department of Energy national laboratories are charged with anticipating with a long leadtime which technologies for nuclear warheads should be developed. The Safe Warhead System Study was constituted to provide Lawrence Livermore National Laboratory management with information and suggestions for making such decisions for enhanced safety warheads. The Minuteman III replacement warheads were analyzed as a test case and that information was used to identify and describe the dominant issues, to develop a methodology and to make initial recommendations. The test case work resulted in several insights into how ongoing design and engineering interacts with the technology ranking and on how to cope with the ubiquitous uncertainties relating to our current ICBM force.

  8. Environmental, health, and safety assessment of photovoltaics

    SciTech Connect

    Rose, E.C.

    1983-10-15

    Potential enviornmental, health, and safety (E,H and S) concerns associated with all phases of the photovoltaic (PV) energy system life cycle are identified and assessed. E,H and S concerns affecting the achievement of National PV Program goals or the viability of specific PV technologies are emphasized. The report is limited to near-term manufacturing process alternatives for crystalline silicon PV materials, addresses flat-plate and concentrator collector designs, and reviews system deployment in grid-connected, roof-mounted, residential and ground-mounted central-station applications. The PV life-cycle phases examined include silicon refinement and manufacture of PV collectors, system deployment, and decommissioning. The primary E,H and S concerns that arise during collector fabrication are associated with occupational exposure to materials of undetermined toxicity or to materials that are known to be hazardous, but for which process control technology may be inadequate. Stricter exposure standards are anticipated for some materials and may indicate a need for further control technology development. Minimizing electric shock hazards is a significant concern during system construction, operation and maintenance, and decommissioning.

  9. Developing a Methodology for Eliciting Subjective Probability Estimates During Expert Evaluations of Safety Interventions: Application for Bayesian Belief Networks

    NASA Technical Reports Server (NTRS)

    Wiegmann, Douglas A.a

    2005-01-01

    The NASA Aviation Safety Program (AvSP) has defined several products that will potentially modify airline and/or ATC operations, enhance aircraft systems, and improve the identification of potential hazardous situations within the National Airspace System (NAS). Consequently, there is a need to develop methods for evaluating the potential safety benefit of each of these intervention products so that resources can be effectively invested to produce the judgments to develop Bayesian Belief Networks (BBN's) that model the potential impact that specific interventions may have. Specifically, the present report summarizes methodologies for improving the elicitation of probability estimates during expert evaluations of AvSP products for use in BBN's. The work involved joint efforts between Professor James Luxhoj from Rutgers University and researchers at the University of Illinois. The Rutgers' project to develop BBN's received funding by NASA entitled "Probabilistic Decision Support for Evaluating Technology Insertion and Assessing Aviation Safety System Risk." The proposed project was funded separately but supported the existing Rutgers' program.

  10. Safety Assessment of Synthetic Fluorphlogopite as Used in Cosmetics.

    PubMed

    Becker, Lillian C; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Andersen, F Alan

    2015-01-01

    The Cosmetic Ingredient Review Expert Panel (the Panel) reviewed the safety of synthetic fluorphlogopite as used in cosmetics. Synthetic fluorphlogopite functions as a bulking agent and a viscosity-increasing agent. The Panel reviewed available animal and human data related to this ingredient along with a previous safety assessment of other magnesium silicates. The Panel concluded that synthetic fluorphlogopite was safe as cosmetic ingredients in the practices of use and concentration as given in this safety assessment. PMID:26684795

  11. Methodology to develop crash modification functions for road safety treatments with fully specified and hierarchical models.

    PubMed

    Chen, Yongsheng; Persaud, Bhagwant

    2014-09-01

    Crash modification factors (CMFs) for road safety treatments are developed as multiplicative factors that are used to reflect the expected changes in safety performance associated with changes in highway design and/or the traffic control features. However, current CMFs have methodological drawbacks. For example, variability with application circumstance is not well understood, and, as important, correlation is not addressed when several CMFs are applied multiplicatively. These issues can be addressed by developing safety performance functions (SPFs) with components of crash modification functions (CM-Functions), an approach that includes all CMF related variables, along with others, while capturing quantitative and other effects of factors and accounting for cross-factor correlations. CM-Functions can capture the safety impact of factors through a continuous and quantitative approach, avoiding the problematic categorical analysis that is often used to capture CMF variability. There are two formulations to develop such SPFs with CM-Function components - fully specified models and hierarchical models. Based on sample datasets from two Canadian cities, both approaches are investigated in this paper. While both model formulations yielded promising results and reasonable CM-Functions, the hierarchical model was found to be more suitable in retaining homogeneity of first-level SPFs, while addressing CM-Functions in sub-level modeling. In addition, hierarchical models better capture the correlations between different impact factors. PMID:24727204

  12. Preliminary Assessment of Operational Hazards and Safety Requirements for Airborne Trajectory Management (ABTM) Roadmap Applications

    NASA Technical Reports Server (NTRS)

    Cotton, William B.; Hilb, Robert; Koczo, Stefan, Jr.; Wing, David J.

    2016-01-01

    A set of five developmental steps building from the NASA TASAR (Traffic Aware Strategic Aircrew Requests) concept are described, each providing incrementally more efficiency and capacity benefits to airspace system users and service providers, culminating in a Full Airborne Trajectory Management capability. For each of these steps, the incremental Operational Hazards and Safety Requirements are identified for later use in future formal safety assessments intended to lead to certification and operational approval of the equipment and the associated procedures. Two established safety assessment methodologies that are compliant with the FAA's Safety Management System were used leading to Failure Effects Classifications (FEC) for each of the steps. The most likely FEC for the first three steps, Basic TASAR, Digital TASAR, and 4D TASAR, is "No effect". For step four, Strategic Airborne Trajectory Management, the likely FEC is "Minor". For Full Airborne Trajectory Management (Step 5), the most likely FEC is "Major".

  13. 14 CFR Appendix C to Part 417 - Flight Safety Analysis Methodologies and Products for an Unguided Suborbital Launch Vehicle Flown...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Flight Safety Analysis Methodologies and Products for an Unguided Suborbital Launch Vehicle Flown With a Wind Weighting Safety System C Appendix C to Part 417 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING...

  14. Salt vulnerability assessment methodology for municipal supply wells

    NASA Astrophysics Data System (ADS)

    Betts, Andrew; Gharabaghi, Bahram; McBean, Ed; Levison, Jana; Parker, Beth

    2015-12-01

    De-icing agents containing chloride ions used for winter road maintenance have the potential to negatively impact groundwater resources for drinking water supplies. A novel methodology using commonly-available geospatial data (land use, well head protection areas) and public accessible data (salt application rates, hydrometric data) to identify salt vulnerable areas (SVAs) for groundwater wells is developed to prioritize implementation of better management practices for road salt applications. The approach uses simple mass-balance terms to collect chloride input from 3 pathways: surface runoff, shallow interflow and baseflow. A risk score is calculated, which depends on the land use within the respective municipal supply well protection area. Therefore, it is plausible to avoid costly and extensive numerical modeling (which also would bear many assumptions, simplifications and uncertainties). The method is applied to perform a vulnerability assessment on twenty municipal water supply wells in the Grand River watershed, Ontario, Canada. The calculated steady-state groundwater recharge chloride concentration for the supply wells is strongly correlated to the measured transient groundwater chloride concentrations in the case study evaluation, with an R2 = 0.84. The new method provides a simple, robust, and practical method for municipalities to assess the long-term risk of chloride contamination of municipal supply wells due to road salt application.

  15. A Methodology for Assessing the Seismic Vulnerability of Highway Systems

    SciTech Connect

    Cirianni, Francis; Leonardi, Giovanni; Scopelliti, Francesco

    2008-07-08

    Modern society is totally dependent on a complex and articulated infrastructure network of vital importance for the existence of the urban settlements scattered on the territory. On these infrastructure systems, usually indicated with the term lifelines, are entrusted numerous services and indispensable functions of the normal urban and human activity.The systems of the lifelines represent an essential element in all the urbanised areas which are subject to seismic risk. It is important that, in these zones, they are planned according to opportune criteria based on two fundamental assumptions: a) determination of the best territorial localization, avoiding, within limits, the places of higher dangerousness; b) application of constructive technologies finalized to the reduction of the vulnerability.Therefore it is indispensable that in any modern process of seismic risk assessment the study of the networks is taken in the rightful consideration, to be integrated with the traditional analyses of the buildings.The present paper moves in this direction, dedicating particular attention to one kind of lifeline: the highway system, proposing a methodology of analysis finalized to the assessment of the seismic vulnerability of the system.

  16. Programmer`s manual for CAMCON: Compliance Assessment Methodology CONtroller

    SciTech Connect

    Rechard, R.P.; Gilkey, A.P.; Rudeen, D.K.; Byle, K.A.; Iuzzolino, H.J.

    1993-05-01

    CAMCON, the Compliance Assessment Methodology CONtroller, is an analysis system that assists in assessing the compliance of the Waste Isolation Pilot Plant (WIPP) with applicable long-term regulations of the US Environmental Protection Agency, including Subpart B of the Environmental Standards for the Management and Disposal of spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes, 40 CFR 191 and 40CFR268.6, which is the portion of the Land Disposal Restrictions implementing the Resource, Conservative, and Recovery Act of 1976, as amended that states the conditions for disposal of hazardous chemical wastes. This manual provides an architectural overview of the CAMCON system. Furthermore this manual presents guidelines and presents suggestions for programmers developing the many different types of software necessary to investigate various events and physical processes of the WIPP. These guidelines include user interface requirements, minimum quality assurance requirements, coding style suggestions, and the use of numerous software libraries developed specifically for or adapted for the CAMCON system.

  17. Patient Safety Culture Assessment in Oman

    PubMed Central

    Al-Mandhari, Ahmed; Al-Zakwani, Ibrahim; Al-Kindi, Moosa; Tawilah, Jihane; Dorvlo, Atsu S.S.; Al-Adawi, Samir

    2014-01-01

    Objective To illustrate the patient safety culture in Oman as gleaned via 12 indices of patient safety culture derived from the Hospital Survey on Patient Safety Culture (HSPSC) and to compare the average positive response rates in patient safety culture between Oman and the USA, Taiwan, and Lebanon. Methods This was a cross-sectional research study employed to gauge the performance of HSPSC safety indices among health workers representing five secondary and tertiary care hospitals in the northern region of Oman. The participants (n=398) represented different professional designations of hospital staff. Analyses were performed using univariate statistics. Results The overall average positive response rate for the 12 patient safety culture dimensions of the HSPSC survey in Oman was 58%. The indices from HSPSC that were endorsed the highest included ‘organizational learning and continuous improvement’ while conversely, ‘non-punitive response to errors’ was ranked the least. There were no significant differences in average positive response rates between Oman and the United States (58% vs. 61%; p=0.666), Taiwan (58% vs. 64%; p=0.386), and Lebanon (58% vs. 61%; p=0.666). Conclusion This study provides the first empirical study on patient safety culture in Oman which is similar to those rates reported elsewhere. It highlights the specific strengths and weaknesses which may stem from the specific milieu prevailing in Oman. PMID:25170407

  18. Processes of technology assessment: The National Transportation Safety Board

    NASA Technical Reports Server (NTRS)

    Weiss, E.

    1972-01-01

    The functions and operations of the Safety Board as related to technology assessment are described, and a brief history of the Safety Board is given. Recommendations made for safety in all areas of transportation and the actions taken are listed. Although accident investigation is an important aspect of NTSB's activity, it is felt that the greatest contribution is in pressing for development of better accident prevention programs. Efforts of the Safety Board in changing transportation technology to improve safety and prevent accidents are illustrated.

  19. Recent developments in Topaz II reactor safety assessments

    SciTech Connect

    Marshall, A.C.

    1993-07-01

    In December 1991, the Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of a US launch of a Russian Topaz II space nuclear power system. The primary mission goal would be to demonstrate and evaluate Nuclear Electric Propulsion technology to establish a capability for future civilian and military missions. A preliminary nuclear safety assessment, involving selected safety analyses, was initiated to determine whether or not a space mission could be conducted safely and within budget constraints. This paper describes the preliminary safety assessment results and the nuclear safety program now being established for the Nuclear Electric Propulsion Space Test Program (NEPSTP).

  20. AN ASSESSMENT OF SIMPLIFIED VS. DETAILED METHODOLOGIES FOR SSI ANALYSES OF DEEPLY EMBEDDED STRUCTURES.

    SciTech Connect

    XU,J.MILLER,C.HOFMAYER,C.GRAVES,H.

    2004-03-04

    Sponsored by the US Nuclear Regulatory Commission (NRC), Brookhaven National Laboratory (BNL) is carrying out a research program to develop a technical basis to support the safety evaluation of deeply embedded and/or buried (DEB) structures as proposed for advanced reactor designs. In this program, the methods and computer programs established for the assessment of soil-structure interaction (SSI) effects for the current generation of light water reactors are evaluated to determine their applicability and adequacy in capturing the seismic behavior of DEB structures. This paper presents an assessment of the simplified vs. detailed methodologies for seismic analyses of DEB structures. In this assessment, a lump-mass beam model is used for the simplified approach and a finite element representation is employed for the detailed method. A typical containment structure embedded in a soil profile representative of a typical nuclear power plant site was utilized, considering various embedment depths from shallow to full burial. BNL used the CARES program for the simplified model and the SASSI2000 program for the detailed analyses. The calculated response spectra at the key locations of the DEB structure are used for the performance assessment of the applied methods for different depths of burial. Included in the paper are: (1) the description of both the simplified and detailed models for the SSI analyses of the DEB structure, (2) the comparison of the analysis results for the different depths of burial between the two methods, and (3) the performance assessment of the analysis methodologies for SSI analyses of DEB structures. The resulting assessment from this study has indicated that simplified methods may be capable of capturing the seismic response for much deeper embedded structures than would be normally allowed by the standard practice.

  1. Optimization of coupled multiphysics methodology for safety analysis of pebble bed modular reactor

    NASA Astrophysics Data System (ADS)

    Mkhabela, Peter Tshepo

    The research conducted within the framework of this PhD thesis is devoted to the high-fidelity multi-physics (based on neutronics/thermal-hydraulics coupling) analysis of Pebble Bed Modular Reactor (PBMR), which is a High Temperature Reactor (HTR). The Next Generation Nuclear Plant (NGNP) will be a HTR design. The core design and safety analysis methods are considerably less developed and mature for HTR analysis than those currently used for Light Water Reactors (LWRs). Compared to LWRs, the HTR transient analysis is more demanding since it requires proper treatment of both slower and much longer transients (of time scale in hours and days) and fast and short transients (of time scale in minutes and seconds). There is limited operation and experimental data available for HTRs for validation of coupled multi-physics methodologies. This PhD work developed and verified reliable high fidelity coupled multi-physics models subsequently implemented in robust, efficient, and accurate computational tools to analyse the neutronics and thermal-hydraulic behaviour for design optimization and safety evaluation of PBMR concept The study provided a contribution to a greater accuracy of neutronics calculations by including the feedback from thermal hydraulics driven temperature calculation and various multi-physics effects that can influence it. Consideration of the feedback due to the influence of leakage was taken into account by development and implementation of improved buckling feedback models. Modifications were made in the calculation procedure to ensure that the xenon depletion models were accurate for proper interpolation from cross section tables. To achieve this, the NEM/THERMIX coupled code system was developed to create the system that is efficient and stable over the duration of transient calculations that last over several tens of hours. Another achievement of the PhD thesis was development and demonstration of full-physics, three-dimensional safety analysis

  2. Development of the damage assessment methodology for ceiling elements

    NASA Astrophysics Data System (ADS)

    Nitta, Yoshihiro; Iwasaki, Atsumi; Nishitani, Akira; Wakatabe, Morimasa; Inai, Shinsuke; Ohdomari, Iwao; Tsutsumi, Hiroki

    2012-04-01

    This paper presents the basic concept of a damage assessment methodology for ceiling elements with the aid of smart sensor board and inspection robot. In this proposed system, the distributed smart sensor boards firstly detect the fact of damage occurrence. Next, the robot inspects the damage location and captures the photographic image of damage condition. The smart sensor board for the proposed system mainly consists of microcontroller, strain gage and LAN module. The inspection robot integrated into the proposed system has a wireless camera and wireless LAN device for receiving signal to manipulate itself. At first, the effectiveness of the smart sensor board and inspection robot is tested by experiments of a full-scale suspended ceiling utilizing shaking table facilities. The model ceiling is subjected to several levels of excitations and thus various levels of damages are caused. Next, this robot inspection scheme is applied to the ceiling of a real structure damaged by the 2011 off the pacific coast of Tohoku Earthquake. The obtained results indicate that the proposed system can detect the location and condition of the damage.

  3. Radiographic assessment of osteoarthritis: comparison between existing methodologies.

    PubMed

    Buckland-Wright

    1999-07-01

    Radiographic sensitivity for quantifying the rate of change in joint space width (JSW) for DMOAD trials, is influenced by the following, which vary between methodologies for imaging hip, knee and hand. Radio-anatomical plane of measurement JSW measurement precision is improve when the (i) joint is in a normal functional position, (ii) X-ray beam is centred on the joint space and (iii) plane of measurement is orthogonal to the beam and articular surfaces, and parallel to the film. Measuring instrument Manual methods, e.g. callipers with graduated magnifying lens or digitisation tablets, suffer from observer variability but are practical and can reliably measure JSW. Computer-based techniques provide precise and accurate JSW measurements. Site of measurement Minimum JSW may lie within the joint's load transmitting region. JSW area and mean area assess the entire JS width. Radiographic magnification This effect is present in hip and knee radiographs and when not corrected, requires increased study numbers. Type of X-ray unit Microfocal radiography's improved spatial resolution increases measurement precision and can decrease study numbers. PMID:10419790

  4. Assessment of the food safety issues related to genetically modified foods.

    PubMed

    Kuiper, H A; Kleter, G A; Noteborn, H P; Kok, E J

    2001-09-01

    International consensus has been reached on the principles regarding evaluation of the food safety of genetically modified plants. The concept of substantial equivalence has been developed as part of a safety evaluation framework, based on the idea that existing foods can serve as a basis for comparing the properties of genetically modified foods with the appropriate counterpart. Application of the concept is not a safety assessment per se, but helps to identify similarities and differences between the existing food and the new product, which are then subject to further toxicological investigation. Substantial equivalence is a starting point in the safety evaluation, rather than an endpoint of the assessment. Consensus on practical application of the principle should be further elaborated. Experiences with the safety testing of newly inserted proteins and of whole genetically modified foods are reviewed, and limitations of current test methodologies are discussed. The development and validation of new profiling methods such as DNA microarray technology, proteomics, and metabolomics for the identification and characterization of unintended effects, which may occur as a result of the genetic modification, is recommended. The assessment of the allergenicity of newly inserted proteins and of marker genes is discussed. An issue that will gain importance in the near future is that of post-marketing surveillance of the foods derived from genetically modified crops. It is concluded, among others that, that application of the principle of substantial equivalence has proven adequate, and that no alternative adequate safety assessment strategies are available. PMID:11576435

  5. Safety/security interface assessments at commercial nuclear power plants

    SciTech Connect

    Byers, K.R.; Brown, P.J.; Norderhaug, L.R.

    1985-07-01

    The findings of the Haynes Task Force Committee (NUREG-0992) are used as the basis for defining safety/security assessment team activities at commercial nuclear power plants in NRC Region V. A safety/security interface assessment outline and the approach used for making the assessments are presented along with the composition of team members. As a result of observing simulated plant emergency conditions during scheduled emergency preparedness exercises, examining security and operational response procedures, and interviewing plant personnel, the team has identified instances where safety/security conflicts can occur. 2 refs.

  6. [Ecological safety assessment of Manas River Basin oasis, Xinjiang].

    PubMed

    Ling, Hong-bo; Xu, Hai-liang; Shi, Wei; Zhang, Qing-qing

    2009-09-01

    By using analytic hierarchy process and fuzzy comprehensive evaluation, an index system for ecological safety assessment was built, and 18 indices in the aspects of water resource, environment, and social economy were selected to assess the ecological safety of Manas River Basin oasis in 2006. In the study area, the ecological situation in 2006 was basically safe, with the membership degree being 0. 3347 and the integrated evaluation score being 0. 551. The water resource safety index, social economy index, and environmental safety index were in the levels of relatively safe, extremely safe, and unsafe, respectively. Water resource index could represent the sustainable development degree of oasis, while social economy index and environment safety index could indicate the oasis development level and environment situation, respectively. These three indices could most reflect the ecological safety level of the oasis. PMID:20030146

  7. Chemical footprint: a methodological framework for bridging life cycle assessment and planetary boundaries for chemical pollution.

    PubMed

    Sala, Serenella; Goralczyk, Malgorzata

    2013-10-01

    The development and use of footprint methodologies for environmental assessment are increasingly important for both the scientific and political communities. Starting from the ecological footprint, developed at the beginning of the 1990s, several other footprints were defined, e.g., carbon and water footprint. These footprints-even though based on a different meaning of "footprint"-integrate life cycle thinking, and focus on some challenging environmental impacts including resource consumption, CO2 emission leading to climate change, and water consumption. However, they usually neglect relevant sources of impacts, as those related to the production and use of chemicals. This article presents and discusses the need and relevance of developing a methodology for assessing the chemical footprint, coupling a life cycle-based approach with methodologies developed in other contexts, such as ERA and sustainability science. Furthermore, different concepts underpin existing footprint and this could be the case also of chemical footprint. At least 2 different approaches and steps to chemical footprint could be envisaged, applicable at the micro- as well as at the meso- and macroscale. The first step (step 1) is related to the account of chemicals use and emissions along the life cycle of a product, sector, or entire economy, to assess potential impacts on ecosystems and human health. The second step (step 2) aims at assessing to which extent actual emission of chemicals harm the ecosystems above their capability to recover (carrying capacity of the system). The latter step might contribute to the wide discussion on planetary boundaries for chemical pollution: the thresholds that should not be surpassed to guarantee a sustainable use of chemicals from an environmental safety perspective. The definition of what the planetary boundaries for chemical pollution are and how the boundaries should be identified is an on-going scientific challenge for ecotoxicology and ecology. In

  8. Comparative risk assessment: an international comparison of methodologies and results.

    PubMed

    Morgenstern, R D; Shih, J; Sessions, S L

    2000-11-01

    Comparative risk assessment (CRA) is a systematic procedure for evaluating the environmental problems affecting a geographic area. This paper looks beyond the U.S. border and examines the experience with CRAs conducted in various developing countries and economies in transition, including Bangkok, Thailand, Cairo, Egypt and Quito, Ecuador, as well as other locations in Eastern Europe, Asia and Central and South America. A recent pilot CRA conducted in Taiwan is also considered. Comparisons are made of both the methodologies and the results across the relatively diverse international literature. The most robust finding is that conventional air pollutants (e.g., particulate matter and lead) consistently rank as high health risks across all of the CRAs examined. Given the varied nature of the settings studied in the CRAs, including level of economic development, urban-rural differences, and climate, this finding is particularly significant. Problems involving drinking water are also ranked as a high or medium health risk in almost all the countries studied. This is consistent with the results of analyses conducted by the World Bank suggesting contamination, limited coverage and erratic service by water supply systems. Beyond the major air pollutants and drinking water, the CRA results diverge significantly across countries. A number of problems involving toxic chemicals, e. g., hazardous air pollutants, rank as high health risks in the US but do not appear as consistent areas of concerns in the other countries studied. This likely reflects the so-called "risk transition" - the shift from sanitation and infection disease problems to those involving industry, vehicles and toxic substances - that often occurs with economic development. It may also reflect the greater information about sources of toxic pollutants in the U.S. For other problems, there are important differences across the developing countries and economies in transition. For example, hazardous and

  9. Safety assessment of 6-hydroxyindole as used in cosmetics.

    PubMed

    Burnett, Christina L; Heldreth, Bart; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Andersen, F Alan

    2014-01-01

    The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of 6-hydroxyindole, which functions as an oxidative hair dye ingredient. The Panel considered relevant animal and human data provided in this safety assessment and concluded that 6-hydroxyindole is safe for use in oxidative hair dye formulations. PMID:25297906

  10. LNG vehicle technology, economics, and safety assessment

    NASA Astrophysics Data System (ADS)

    Powars, Charles A.; Moyer, Carl B.; Lowell, Douglas D.

    1994-02-01

    Liquid natural gas (LNG) is an attractive transportation fuel because of its high heating value and energy density (i.e., Btu/lb. and Btu/gal.), clean burning characteristics, relatively low cost ($/Btu), and domestic availability. This research evaluated LNG vehicle and refueling system technology, economics, and safety. Prior and current LNG vehicle projects were studied to identify needed technology improvements. Life-cycle cost analyses considered various LNG vehicle and fuel supply options. Safety records, standards, and analysis methods were reviewed. The LNG market niche is centrally fueled heavy-duty fleet vehicles with high fuel consumption. For these applications, fuel cost savings can amortize equipment capital costs.

  11. Soft Mathematical Aggregation in Safety Assessment and Decision Analysis

    SciTech Connect

    Cooper, J. Arlin

    1999-06-10

    This paper improves on some of the limitations of conventional safety assessment and decision analysis methods. It develops a top-down mathematical method for expressing imprecise individual metrics as possibilistic or fuzzy numbers and shows how they may be combined (aggregated) into an overall metric, also portraying the inherent uncertainty. Both positively contributing and negatively contributing factors are included. Metrics are weighted according to significance of the attribute and evaluated as to contribution toward the attribute. Aggregation is performed using exponential combination of the metrics, since the accumulating effect of such factors responds less and less to additional factors. This is termed soft mathematical aggregation. Dependence among the contributing factors is accounted for by incorporating subjective metrics on overlap of the factors and by correspondingly reducing the overall contribution of these combinations to the overall aggregation. Decisions corresponding to the meaningfulness of the results are facilitated in several ways. First, the results are compared to a soft threshold provided by a sigmoid function. Second, information is provided on input ''Importance'' and ''Sensitivity,'' in order to know where to place emphasis on controls that may be necessary. Third, trends in inputs and outputs are tracked in order to add important information to the decision process. The methodology has been implemented in software.

  12. A Methodology for the Assessment of Experiential Learning Lean: The Lean Experience Factory Study

    ERIC Educational Resources Information Center

    De Zan, Giovanni; De Toni, Alberto Felice; Fornasier, Andrea; Battistella, Cinzia

    2015-01-01

    Purpose: The purpose of this paper is to present a methodology to assess the experiential learning processes of learning lean in an innovative learning environment: the lean model factories. Design/methodology/approach: A literature review on learning and lean management literatures was carried out to design the methodology. Then, a case study…

  13. Safety assessment of the liquid-fed ceramic melter process

    SciTech Connect

    Buelt, J.L.; Partain, W.L.

    1980-08-01

    As part of its development program for the solidification of high-level nuclear waste, Pacific Northwest Laboratory assessed the safety issues for a complete liquid-fed ceramic melter (LFCM) process. The LFCM process, an adaption of commercial glass-making technology, is being developed to convert high-level liquid waste from the nuclear fuel cycle into glass. This safety assessment uncovered no unresolved or significant safety problems with the LFCM process. Although in this assessment the LFCM process was not directly compared with other solidification processes, the safety hazards of the LFCM process are comparable to those of other processes. The high processing temperatures of the glass in the LFCM pose no additional significant safety concerns, and the dispersible inventory of dried waste (calcine) is small. This safety assessment was based on the nuclear power waste flowsheet, since power waste is more radioactive than defense waste at the time of solidification, and all accident conditions for the power waste would have greater radiological consequences than those for defense waste. An exhaustive list of possible off-standard conditions and equipment failures was compiled. These accidents were then classified according to severity of consequence and type of accident. Radionuclide releases to the stack were calculated for each group of accidents using conservative assumptions regarding the retention and decontamination features of the process and facility. Two recommendations that should be considered by process designers are given in the safety assessment.

  14. Safety assessment of probiotics for human use

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The safety of probiotics is tied to their intended use, which includes consideration of the potential vulnerability of the consumer or patient, dose and duration of consumption, and both the manner and frequency of administration. Unique to probiotics is that they are living organisms when administ...

  15. Teaching Technology by Assessing Vehicle Safety

    ERIC Educational Resources Information Center

    Lazaros, Edward J.

    2012-01-01

    According to the National Center for Injury Prevention and Control, motor vehicle crashes are the leading cause of death among Americans aged 2-34. Many states have adopted periodic motor vehicle inspection (PMVI) to ensure the safety of the highways, and states that have adopted PMVI report a reduction in highway fatalities. Deaths and injuries…

  16. AGRICULTURAL CHEMICAL SAFETY ASSESSMENT: A MULTISECTOR APPROACH TO THE MODERNIZATION OF HUMAN SAFETY REQUIREMENTS.

    EPA Science Inventory

    Better understanding of toxicological mechanisms, enhanced testing capabilities, and demands for more sophisticated data for safety and health risk assessment have generated international interest in improving the current testing paradigm for agricultural chemicals. To address th...

  17. A Mechanistic, Model-Based Approach to Safety Assessment in Clinical Development

    PubMed Central

    Lippert, J; Brosch, M; von Kampen, O; Meyer, M; Siegmund, H.-U; Schafmayer, C; Becker, T; Laffert, B; Görlitz, L; Schreiber, S; Neuvonen, P J; Niemi, M; Hampe, J; Kuepfer, L

    2012-01-01

    Assessing the safety of pharmacotherapies is a primary goal of clinical trials in drug development. The low frequency of relevant side effects, however, often poses a significant challenge for risk assessment. Methodologies allowing robust extrapolation of safety statistics based on preclinical data and information from clinical trials with limited numbers of patients are hence needed to further improve safety and efficacy in the drug development process. Here, we present a generic systems pharmacology approach integrating prior physiological and pharmacological knowledge, preclinical data, and clinical trial results, which allows predicting adverse event rates related to drug exposure. Possible fields of application involve high-risk populations, novel drug candidates, and different dosing scenarios. As an example, the approach is applied to simvastatin and pravastatin and the prediction of myopathy rates in a population with a genotype leading to a significantly increased myopathy risk. PMID:23835795

  18. Positive lists of cosmetic ingredients: Analytical methodology for regulatory and safety controls - A review.

    PubMed

    Lores, Marta; Llompart, Maria; Alvarez-Rivera, Gerardo; Guerra, Eugenia; Vila, Marlene; Celeiro, Maria; Lamas, J Pablo; Garcia-Jares, Carmen

    2016-04-01

    Cosmetic products placed on the market and their ingredients, must be safe under reasonable conditions of use, in accordance to the current legislation. Therefore, regulated and allowed chemical substances must meet the regulatory criteria to be used as ingredients in cosmetics and personal care products, and adequate analytical methodology is needed to evaluate the degree of compliance. This article reviews the most recent methods (2005-2015) used for the extraction and the analytical determination of the ingredients included in the positive lists of the European Regulation of Cosmetic Products (EC 1223/2009): comprising colorants, preservatives and UV filters. It summarizes the analytical properties of the most relevant analytical methods along with the possibilities of fulfilment of the current regulatory issues. The cosmetic legislation is frequently being updated; consequently, the analytical methodology must be constantly revised and improved to meet safety requirements. The article highlights the most important advances in analytical methodology for cosmetics control, both in relation to the sample pretreatment and extraction and the different instrumental approaches developed to solve this challenge. Cosmetics are complex samples, and most of them require a sample pretreatment before analysis. In the last times, the research conducted covering this aspect, tended to the use of green extraction and microextraction techniques. Analytical methods were generally based on liquid chromatography with UV detection, and gas and liquid chromatographic techniques hyphenated with single or tandem mass spectrometry; but some interesting proposals based on electrophoresis have also been reported, together with some electroanalytical approaches. Regarding the number of ingredients considered for analytical control, single analyte methods have been proposed, although the most useful ones in the real life cosmetic analysis are the multianalyte approaches. PMID:26995636

  19. NextGen Future Safety Assessment Game

    NASA Technical Reports Server (NTRS)

    Ancel, Ersin; Gheorghe, Adian; Jones, Sharon Monica

    2010-01-01

    The successful implementation of the next generation infrastructure systems requires solid understanding of their technical, social, political and economic aspects along with their interactions. The lack of historical data that relate to the long-term planning of complex systems introduces unique challenges for decision makers and involved stakeholders which in turn result in unsustainable systems. Also, the need to understand the infrastructure at the societal level and capture the interaction between multiple stakeholders becomes important. This paper proposes a methodology in order to develop a holistic approach aiming to provide an alternative subject-matter expert (SME) elicitation and data collection method for future sociotechnical systems. The methodology is adapted to Next Generation Air Transportation System (NextGen) decision making environment in order to demonstrate the benefits of this holistic approach.

  20. NextGen Future Safety Assessment Game

    NASA Technical Reports Server (NTRS)

    Ancel, Ersin; Gheorghe, Adrian; Jones, Sharon Monica

    2011-01-01

    The successful implementation of the next generation infrastructure systems requires solid understanding of their technical, social, political and economic aspects along with their interactions. The lack of historical data that relate to the long-term planning of complex systems introduces unique challenges for decision makers and involved stakeholders which in turn result in unsustainable systems. Also, the need to understand the infrastructure at the societal level and capture the interaction between multiple stakeholders becomes important. This paper proposes a methodology in order to develop a holistic approach aiming to provide an alternative subject-matter expert (SME) elicitation and data collection method for future sociotechnical systems. The methodology is adapted to Next Generation Air Transportation System (NextGen) decision making environment in order to demonstrate the benefits of this holistic approach.

  1. Assessing the relationship between patient safety culture and EHR strategy.

    PubMed

    Ford, Eric W; Silvera, Geoffrey A; Kazley, Abby S; Diana, Mark L; Huerta, Timothy R

    2016-07-11

    Purpose - The purpose of this paper is to explore the relationship between hospitals' electronic health record (EHR) adoption characteristics and their patient safety cultures. The "Meaningful Use" (MU) program is designed to increase hospitals' adoption of EHR, which will lead to better care quality, reduce medical errors, avoid unnecessary cost, and promote a patient safety culture. To reduce medical errors, hospital leaders have been encouraged to promote safety cultures common to high-reliability organizations. Expecting a positive relationship between EHR adoption and improved patient safety cultures appears sound in theory, but it has yet to be empirically demonstrated. Design/methodology/approach - Providers' perceptions of patient safety culture and counts of patient safety incidents are explored in relationship to hospital EHR adoption patterns. Multi-level modeling is employed to data drawn from the Agency for Healthcare Research and Quality's surveys on patient safety culture (level 1) and the American Hospital Association's survey and healthcare information technology supplement (level 2). Findings - The findings suggest that the early adoption of EHR capabilities hold a negative association to the number of patient safety events reported. However, this relationship was not present in providers' perceptions of overall patient safety cultures. These mixed results suggest that the understanding of the EHR-patient safety culture relationship needs further research. Originality/value - Relating EHR MU and providers' care quality attitudes is an important leading indicator for improved patient safety cultures. For healthcare facility managers and providers, the ability to effectively quantify the impact of new technologies on efforts to change organizational cultures is important for pinpointing clinical areas for process improvements. PMID:27298060

  2. Savannah River Site K-Reactor Probabilistic Safety Assessment

    SciTech Connect

    Brandyberry, M.D.; Bailey, R.T.; Baker, W.H.; Kearnaghan, D.P.; O`Kula, K.R.; Wittman, R.S.; Woody, N.D.; Amos, C.N.; Weingardt, J.J.

    1992-12-01

    This report gives the results of a Savannah River Site (SRS) K-Reactor Probabilistic Safety Assessment (PSA). Measures of adverse consequences to health and safety resulting from representations of severe accidents in SRS reactors are presented. In addition, the report gives a summary of the methods employed to represent these accidents and to assess the resultant consequences. The report is issued to provide useful information to the U. S. Department of Energy (DOE) on the risk of operation of SRS reactors, for insights into severe accident phenomena that contribute to this risk, and in support of improved bases for other DOE programs in Heavy Water Reactor safety.

  3. Complementary safety assessments of the French nuclear facilities

    NASA Astrophysics Data System (ADS)

    Pouget-Abadie, Xavier

    2012-05-01

    EDF has conducted, after the Fukushima event, complementary safety assessments of its nuclear facilities. The aim of this in-depth review was to assess the resilience of each plant to extreme external hazards, situations that could lead to severe accident conditions. These analyses demonstrate a good level of safety for all of EDF's nuclear facilities. Supplementary measures post-Fukushima have been put forward to the ASN with the aim of continuing to improve the level of safety at the plants. Once the ASN position is issued, EDF will develop an action plan over several years, covering both supplementary studies and modifications that have been identified.

  4. Safety assessment of modified terephthalate polymers as used in cosmetics.

    PubMed

    Becker, Lillian C; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Andersen, F Alan

    2014-01-01

    The safety of 6 modified terephthalate polymers as cosmetic ingredients was assessed. These ingredients mostly function as exfoliants, bulking agents, hair fixatives, and viscosity-increasing agents-nonaqueous. Polyethylene terephthalate (PET) is used in leave-on products up to 100% and in rinse-off products up to 2%. The Cosmetic Ingredient Review Expert Panel (Panel) considered that the PET used in cosmetics is chemically equivalent to that used in medical devices. The Panel determined that the Food and Drug Administration's determination of safety of PET in several medical devices, which included human and animal safety data, can be used as the basis for the determination of safety of PET and related polymers used in cosmetics. Use studies of cosmetic eye products that contain PET demonstrated no ocular irritation or dermal sensitization. The Panel concluded that modified terephthalate polymers were safe as cosmetic ingredients in the practices of use and concentration described in this safety assessment. PMID:25297907

  5. Selected component failure rate values from fusion safety assessment tasks

    SciTech Connect

    Cadwallader, L.C.

    1998-09-01

    This report is a compilation of component failure rate and repair rate values that can be used in magnetic fusion safety assessment tasks. Several safety systems are examined, such as gas cleanup systems and plasma shutdown systems. Vacuum system component reliability values, including large vacuum chambers, have been reviewed. Values for water cooling system components have also been reported here. The report concludes with the examination of some equipment important to personnel safety, atmospheres, combustible gases, and airborne releases of radioactivity. These data should be useful to system designers to calculate scoping values for the availability and repair intervals for their systems, and for probabilistic safety or risk analysts to assess fusion systems for safety of the public and the workers.

  6. Selected Component Failure Rate Values from Fusion Safety Assessment Tasks

    SciTech Connect

    Cadwallader, Lee Charles

    1998-09-01

    This report is a compilation of component failure rate and repair rate values that can be used in magnetic fusion safety assessment tasks. Several safety systems are examined, such as gas cleanup systems and plasma shutdown systems. Vacuum system component reliability values, including large vacuum chambers, have been reviewed. Values for water cooling system components have also been reported here. The report concludes with the examination of some equipment important to personnel safety, atmospheres, combustible gases, and airborne releases of radioactivity. These data should be useful to system designers to calculate scoping values for the availability and repair intervals for their systems, and for probabilistic safety or risk analysts to assess fusion systems for safety of the public and the workers.

  7. RISK ASSESSMENT METHODOLOGY FOR DETERMINING GROUNDWATER CONTAMINATION FROM LANDFILL SLUDGE

    EPA Science Inventory

    Contaminant concentration criteria are required to prevent contaminant infiltration from leading to conditions which exceed health criteria. A methodology of groundwater has been described which may be used to select those criteria and quantify concentrations associated with plac...

  8. Extreme Storm Event Assessments for Nuclear Facilities and Dam Safety

    NASA Astrophysics Data System (ADS)

    England, J. F.; Nicholson, T. J.; Prasad, R.

    2008-12-01

    Extreme storm events over the last 35 years are being assessed to evaluate flood estimates for safety assessments of dams, nuclear power plants, and other high-hazard structures in the U.S. The current storm rainfall design standard for evaluating the flood potential at dams and non-coastal nuclear power plants is the Probable Maximum Precipitation (PMP). PMP methods and estimates are published in the National Weather Service generalized hydrometeorological reports (HMRs). A new Federal Interagency cooperative effort is reviewing hydrometeorologic data from large storms which have occurred in the last 20 to 40 years and were not included in the database used in the development of many of the HMRs. Extreme storm data, such as the January 1996 storm in Pennsylvania, June 2008 Iowa storms, and Hurricanes Andrew (1992), Floyd (1999), Isabel (2003), Katrina (2005), need to be systematically assembled and analyzed for use in these regional extreme storm studies. Storm maximization, transposition, envelopment, and depth-area duration procedures will incorporate recent advances in hydrometeorology, including radar precipitation data and stochastic storm techniques. We describe new cooperative efforts to develop a database of extreme storms and to examine the potential impacts of recent extreme storms on PMP estimates. These efforts will be coordinated with Federal agencies, universities, and the private sector through an Extreme Storm Events Work Group under the Federal Subcommittee on Hydrology. This work group is chartered to coordinate studies and develop databases for reviewing and improving methodologies and data collection techniques used to estimate design precipitation up to and including the PMP. The initial effort focuses on collecting and reviewing extreme storm event data in the Southeastern U.S. that have occurred since Tropical Storm Agnes (1972). Uncertainties and exceedance probability estimates of PMP are being explored. Potential effects of climate

  9. 76 FR 71431 - Civil Penalty Calculation Methodology

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... TRANSPORTATION Federal Motor Carrier Safety Administration Civil Penalty Calculation Methodology AGENCY: Federal... Uniform Fine Assessment (UFA) algorithm, which FMCSA currently uses for calculation of civil penalties... methodology for calculation of certain civil penalties. To induce compliance with federal regulations,...

  10. Methodology for reliability based condition assessment. Application to concrete structures in nuclear plants

    SciTech Connect

    Mori, Y.; Ellingwood, B.

    1993-08-01

    Structures in nuclear power plants may be exposed to aggressive environmental effects that cause their strength to decrease over an extended period of service. A major concern in evaluating the continued service for such structures is to ensure that in their current condition they are able to withstand future extreme load events during the intended service life with a level of reliability sufficient for public safety. This report describes a methodology to facilitate quantitative assessments of current and future structural reliability and performance of structures in nuclear power plants. This methodology takes into account the nature of past and future loads, and randomness in strength and in degradation resulting from environmental factors. An adaptive Monte Carlo simulation procedure is used to evaluate time-dependent system reliability. The time-dependent reliability is sensitive to the time-varying load characteristics and to the choice of initial strength and strength degradation models but not to correlation in component strengths within a system. Inspection/maintenance strategies are identified that minimize the expected future costs of keeping the failure probability of a structure at or below an established target failure probability during its anticipated service period.

  11. Defining the methodological challenges and opportunities for an effective science of sociotechnical systems and safety

    PubMed Central

    Waterson, Patrick; Robertson, Michelle M.; Cooke, Nancy J.; Militello, Laura; Roth, Emilie; Stanton, Neville A.

    2015-01-01

    An important part of the application of sociotechnical systems theory (STS) is the development of methods, tools and techniques to assess human factors and ergonomics workplace requirements. We focus in this paper on describing and evaluating current STS methods for workplace safety, as well as outlining a set of six case studies covering the application of these methods to a range of safety contexts. We also describe an evaluation of the methods in terms of ratings of their ability to address a set of theoretical and practical questions (e.g. the degree to which methods capture static/dynamic aspects of tasks and interactions between system levels). The outcomes from the evaluation highlight a set of gaps relating to the coverage and applicability of current methods for STS and safety (e.g. coverage of external influences on system functioning; method usability). The final sections of the paper describe a set of future challenges, as well as some practical suggestions for tackling these. Practitioner Summary: We provide an up-to-date review of STS methods, a set of case studies illustrating their use and an evaluation of their strengths and weaknesses. The paper concludes with a ‘roadmap’ for future work. PMID:25832121

  12. Cancer risk assessment of extremely low frequency electric and magnetic fields: a critical review of methodology.

    PubMed Central

    McCann, J

    1998-01-01

    This review provides a discussion of cancer risk assessment methodology pertinent to developing a strategy for extremely low frequency electric and magnetic fields (EMF). Approaches taken for chemical agents or ionizing radiation in six key topic areas are briefly reviewed, and then those areas are examined from the perspective of EMF, identifying issues to be addressed in developing a risk assessment strategy. The following recommendations are offered: 1) risk assessment should be viewed as an iterative process that informs an overall judgment as to health risk and consists of a complex of related activities incorporating both positive and negative data, tumor and nontumor end points, and human and nonhuman sources of information; 2) a hazard identification resulting in a conclusion of weak or null effects, such as may be associated with EMF, will need to assign significant weight to animal cancer bioassays conducted under defined exposure conditions as well as to human epidemiologic studies; 3) a default factor to account for possible age differences in sensitivity to carcinogenesis should be included in an EMF risk assessment; 4) lack of evidence of dose response and the apparent lack of DNA reactivity of EMF suggest that a safety (or uncertainty) factor or margin of exposure type of risk characterization may be most appropriate; and 5) an EMF risk assessment should permit at least tentative conclusions to be reached as to the limits of carcinogenic risk from exposure to EMF, and should also define an efficient research agenda aimed at clarifying uncertainties appropriate to a more complete assessment. PMID:9799185

  13. Evaluation of the safety of C-spine clearance by paramedics: design and methodology

    PubMed Central

    2011-01-01

    Background Canadian Emergency Medical Services annually transport 1.3 million patients with potential neck injuries to local emergency departments. Less than 1% of those patients have a c-spine fracture and even less (0.5%) have a spinal cord injury. Most injuries occur before the arrival of paramedics, not during transport to the hospital, yet most patients are transported in ambulances immobilized. They stay fully immobilized until a bed is available, or until physician assessment and/or X-rays are complete. The prolonged immobilization is often unnecessary and adds to the burden of already overtaxed emergency medical services systems and crowded emergency departments. Methods/Design The goal of this study is to evaluate the safety and potential impact of an active strategy that allows paramedics to assess very low-risk trauma patients using a validated clinical decision rule, the Canadian C-Spine Rule, in order to determine the need for immobilization during transport to the emergency department. This cohort study will be conducted in Ottawa, Canada with one emergency medical service. Paramedics with this service participated in an earlier validation study of the Canadian C-Spine Rule. Three thousand consecutive, alert, stable adult trauma patients with a potential c-spine injury will be enrolled in the study and evaluated using the Canadian C-Spine Rule to determine the need for immobilization. The outcomes that will be assessed include measures of safety (numbers of missed fractures and serious adverse outcomes), measures of clinical impact (proportion of patients transported without immobilization, key time intervals) and performance of the Rule. Discussion Approximately 40% of all very low-risk trauma patients could be transported safely, without c-spine immobilization, if paramedics were empowered to make clinical decisions using the Canadian C-Spine Rule. This safety study is an essential step before allowing all paramedics across Canada to selectively

  14. Ways of improvement of methodological approaches to the assessment of the effectiveness of physical protection systems of nuclear facilities in consideration of modern requirements and threats

    NASA Astrophysics Data System (ADS)

    Vlasenko, E. A.; Nikienko, A. V.; Demyanuk, D. G.

    2016-06-01

    Methodological approaches to the assessment of the effectiveness of physical protection systems developed by Russian and foreign researchers are reviewed. Some ways of improvement of these approaches are offered. They consider tactics overview, application of two-person rule, aspects of inherent safety of nuclear materials, proposals on the use of test reliability data.

  15. Safety assessment of genetically modified plants with deliberately altered composition.

    PubMed

    Halford, Nigel G; Hudson, Elizabeth; Gimson, Amy; Weightman, Richard; Shewry, Peter R; Tompkins, Steven

    2014-08-01

    The development and marketing of 'novel' genetically modified (GM) crops in which composition has been deliberately altered poses a challenge to the European Union (EU)'s risk assessment processes, which are based on the concept of substantial equivalence with a non-GM comparator. This article gives some examples of these novel GM crops and summarizes the conclusions of a report that was commissioned by the European Food Safety Authority on how the EU's risk assessment processes could be adapted to enable their safety to be assessed. PMID:24735114

  16. Safety assessment of genetically modified plants with deliberately altered composition

    PubMed Central

    Halford, Nigel G; Hudson, Elizabeth; Gimson, Amy; Weightman, Richard; Shewry, Peter R; Tompkins, Steven

    2014-01-01

    The development and marketing of ‘novel’ genetically modified (GM) crops in which composition has been deliberately altered poses a challenge to the European Union (EU)'s risk assessment processes, which are based on the concept of substantial equivalence with a non-GM comparator. This article gives some examples of these novel GM crops and summarizes the conclusions of a report that was commissioned by the European Food Safety Authority on how the EU's risk assessment processes could be adapted to enable their safety to be assessed. PMID:24735114

  17. A fuzzy logic methodology for fault-tree analysis in critical safety systems

    SciTech Connect

    Erbay, A.; Ikonomopoulos, A. )

    1993-01-01

    A new approach for fault-tree analysis in critical safety systems employing fuzzy sets for information representation is presented in this paper. The methodology is based on the utilization of the extension principle for mapping crisp measurements to various degrees of membership in the fuzzy set of linguistic Truth. Criticality alarm systems are used in miscellaneous nuclear fuel processing, handling, and storage facilities to reduce the risk associated with fissile material operations. Fault-tree methodologies are graphic illustrations of tile failure logic associated with the development of a particular system failure (top event) from basic subcomponent failures (primary events). The term event denotes a dynamic change of state that occurs to system elements, which may include hardware, software, human, or environmental factors. A fault-tree represents a detailed, deductive, analysis that requires extensive system information. The knowledge incorporated in a fault tree can be articulated in logical rules of the form [open quotes]IF A is true THEN B is true.[close quotes] However, it is well known that this type of syllogism fails to give an answer when the satisfaction of the antecedent clause is only partial. Zadeh suggested a new type of fuzzy conditional inference. This type of syllogism (generalized modus ponens) reads as follows: Premise: A is partially true Implication: IF A is true THEN B is true Conclusion: B is partially-true. In generalized modus ponens, the antecedent is true only to some degree; hence, it is desired to compute the grade to which the consequent is satisfied. Fuzzy sets provide a natural environment for this type of computation because fuzzy variables (e.g., B) can take fuzzy values (e.g., partially-true).

  18. INPRO Assessment of an INS in the Area of Safety of Fuel Cycle Installations

    SciTech Connect

    Raj, B.; Busurin, Y.; Depisch, F.

    2006-07-01

    INPRO has defined requirements organized in a hierarchy of Basic Principles, User Requirements and Criteria (consisting of an indicator and an acceptance limit) to be met by innovative nuclear reactor systems (INS) in six areas, namely: economics, safety, waste management, environment, proliferation resistance, and infrastructure. If an INS meets all requirements in all areas it represents a sustainable system for the supply of energy, capable of making a significant contribution to meeting the energy needs of the 21. century. Draft manuals have been developed, for each INPRO area, to provide guidance for performing an assessment of whether an INS meets the INPRO requirements in a given area. The manuals set out the information that needs to be assembled to perform an assessment and provide guidance on selecting the acceptance limits and, for a given INS, for determining the value of the indicators for comparison with the associated acceptance limits. Each manual also includes an example of a specific assessment to illustrate the guidance. This paper discusses the manual for performing an INPRO assessment in the area of safety of fuel cycle installations. The example, chosen solely for the purpose of illustrating the INPRO methodology, describes an assessment of an MOX fuel fabrication plant based on sol-gel technology and illustrates an assessment performed for an INS at an early stage of development. The safety issues and the assessment steps are presented in detail in the paper. (authors)

  19. Safety Assessment of Low- and Intermediate-Level Waste Disposal at Vaalputs, South Africa

    NASA Astrophysics Data System (ADS)

    Kozak, M. W.; Beyleveld, C.; Carolissen, A.

    2006-12-01

    The South African Nuclear Energy Corporation (Necsa ) owns and operates the Vaalputs radioactive waste disposal site, which is South Africa's designated facility for the disposal of low-and intermediate level radioactive waste (LILW). The bulk of the currently authorized LILW disposal at Vaalputs was generated at the Koeberg Nuclear Power Station (KNPS) near Cape Town. However, Necsa has generated wastes associated with research and uranium enrichment that are currently in storage, which are intended for disposal at Vaalputs. In addition, South Africa is currently considering expansion of its nuclear power generating capabilities, both through construction of a second pressurized water reactor (PWR) and through the development of the Pebble Bed Modular Reactor (PBMR) design. The proposed change in waste characteristics warrants a safety review of the Vaalputs authorization for the disposal of LILW. As part of the safety review, an updated postclosure safety assessment is being conducted. This current safety assessment is being conducted according to an internationally accepted state-of-the-art safety assessment methodology (IAEA, 2004), and is defensible, transparent, and credible. A formal scenario-generation methodology is being applied, which has led to the identification of a number of site-specific scenarios for further consideration. Specific features of the site, the disposal facility design, and local behavior patterns were used to screen Features, Events, and Processes (FEPs) from consideration. Specific FEPs were chosen as initiating FEPs for scenarios to be considered in the safety assessment, based on a combination of reasonable likelihood and high consequence for the analysis. Scenarios identified by this process are A nominal scenario represents the intended design basis for the long-term function of the repository. A late-subsidence scenario is included, in which subsidence occurs after active institutional control measures cease, such that

  20. Assessing the Impact of Entrepreneurship Education Programmes: A New Methodology

    ERIC Educational Resources Information Center

    Fayolle, Alain; Gailly, Benoit; Lassas-Clerc, Narjisse

    2006-01-01

    Purpose: Facing the multiplication of entrepreneurship education programmes (EEP) and the increasing resources allocated, there is a need to develop a common framework to evaluate the design of those programmes. The purpose of this article is to propose such a framework, based on the theory of planned behaviour (TPB). Design/methodology/approach:…

  1. Assessing L2 Knowledge of Spanish Clitic Placement: Converging Methodologies.

    ERIC Educational Resources Information Center

    Duffield, Nigel; White, Lydia

    1999-01-01

    Reports on an experiment investigating adult second language (L2) acquisition of Spanish object clitic placement by native speakers of English and French. Two experimental methodologies are compared: an on-line sentence matching task and an off-line grammaticality judgment task. (Author/VWL)

  2. Environment, Safety, and Health Risk Assessment Program (ESHRAP)

    SciTech Connect

    Eide, Steven Arvid; Thomas Wierman

    2003-12-01

    The Environment, Safety and Health Risk Assessment Program (ESHRAP) models human safety and health risk resulting from waste management and environmental restoration activities. Human safety and health risks include those associated with storing, handling, processing, transporting, and disposing of radionuclides and chemicals. Exposures to these materials, resulting from both accidents and normal, incident-free operation, are modeled. In addition, standard industrial risks (falls, explosions, transportation accidents, etc.) are evaluated. Finally, human safety and health impacts from cleanup of accidental releases of radionuclides and chemicals to the environment are estimated. Unlike environmental impact statements and safety analysis reports, ESHRAP risk predictions are meant to be best estimate, rather than bounding or conservatively high. Typically, ESHRAP studies involve risk predictions covering the entire waste management or environmental restoration program, including such activities as initial storage, handling, processing, interim storage, transportation, and final disposal. ESHRAP can be used to support complex environmental decision-making processes and to track risk reduction as activities progress.

  3. Safety culture assessment in community pharmacy: development, face validity, and feasibility of the Manchester Patient Safety Assessment Framework

    PubMed Central

    Ashcroft, D; Morecroft, C; Parker, D; Noyce, P

    2005-01-01

    Objective: To develop a framework that could be used by community pharmacies to self-assess their current level of safety culture maturity, which has high face validity and is both acceptable and feasible for use in this setting. Design: An iterative review process in which the framework was developed and evaluated through a series of 10 focus groups with a purposive sample of 67 community pharmacists and support staff in the UK. Main outcome measures: Development of the framework and qualitative process feedback on its acceptability, face validity, and feasibility for use in community pharmacies. Results: Using this process, a version of the Manchester Patient Safety Assessment Framework (MaPSAF) was developed that is suitable for application to community pharmacies. The participants were able to understand the concepts, recognised differences between the five stages of safety culture maturity, and concurred with the descriptions from personal experience. They also indicated that they would be willing to use the framework but recognised that staff would require protected time in order to complete the assessment. Conclusions: In practice the MaPSAF is likely to have a number of uses including raising awareness about patient safety and illustrating any differences in perception between staff, stimulating discussion about the strengths and weaknesses of patient safety culture within the pharmacy, identifying areas for improvement, and evaluating patient safety interventions and tracking changes over time. This will support the development of a mature safety culture in community pharmacies. PMID:16326787

  4. The TRIPOD e-learning Platform for the Training of Earthquake Safety Assessment

    NASA Astrophysics Data System (ADS)

    Coppari, S.; Di Pasquale, G.; Goretti, A.; Papa, F.; Papa, S.; Paoli, G.; Pizza, A. G.; Severino, M.

    2008-07-01

    The paper summarizes the results of the in progress EU Project titled TRIPOD (Training Civil Engineers on Post-Earthquake Safety Assessment of Damaged Buildings), funded under the Leonardo Da Vinci program. The main theme of the project is the development of a methodology and a learning platform for the training of technicians involved in post-earthquake building safety inspections. In the event of a catastrophic earthquake, emergency building inspections constitute a major undertaking with severe social impact. Given the inevitable chaotic conditions and the urgent need of a great number of specialized individuals to carry out inspections, past experience indicates that inspection teams are often formed in an adhoc manner, under stressful conditions, at a varying levels of technical expertise and experience, sometime impairing the reliability and consistency of the inspection results. Furthermore each Country has its own building damage and safety assessment methodology, developed according to its experience, laws, building technology and seismicity. This holds also for the partners participating to the project (Greece, Italy, Turkey, Cyprus), that all come from seismically sensitive Mediterranean countries. The project aims at alleviating the above shortcomings by designing and developing a training methodology and e-platform, forming a complete training program targeted at inspection engineers, specialized personnel and civil protection agencies. The e-learning platform will provide flexible and friendly authoring mechanisms, self-teaching and assessment capabilities, course and trainee management, etc. Courses will be also made available as stand-alone multimedia applications on CD and in the form of a complete pocket handbook. Moreover the project will offer the possibility of upgrading different experiences and practices: a first step towards the harmonization of methodologies and tools of different Countries sharing similar problems. Finally, through wide

  5. The TRIPOD e-learning Platform for the Training of Earthquake Safety Assessment

    SciTech Connect

    Coppari, S.; Di Pasquale, G.; Goretti, A.; Papa, F.; Papa, S.; Paoli, G.; Pizza, A. G.; Severino, M.

    2008-07-08

    The paper summarizes the results of the in progress EU Project titled TRIPOD (Training Civil Engineers on Post-Earthquake Safety Assessment of Damaged Buildings), funded under the Leonardo Da Vinci program. The main theme of the project is the development of a methodology and a learning platform for the training of technicians involved in post-earthquake building safety inspections. In the event of a catastrophic earthquake, emergency building inspections constitute a major undertaking with severe social impact. Given the inevitable chaotic conditions and the urgent need of a great number of specialized individuals to carry out inspections, past experience indicates that inspection teams are often formed in an adhoc manner, under stressful conditions, at a varying levels of technical expertise and experience, sometime impairing the reliability and consistency of the inspection results. Furthermore each Country has its own building damage and safety assessment methodology, developed according to its experience, laws, building technology and seismicity. This holds also for the partners participating to the project (Greece, Italy, Turkey, Cyprus), that all come from seismically sensitive Mediterranean countries. The project aims at alleviating the above shortcomings by designing and developing a training methodology and e-platform, forming a complete training program targeted at inspection engineers, specialized personnel and civil protection agencies. The e-learning platform will provide flexible and friendly authoring mechanisms, self-teaching and assessment capabilities, course and trainee management, etc. Courses will be also made available as stand-alone multimedia applications on CD and in the form of a complete pocket handbook. Moreover the project will offer the possibility of upgrading different experiences and practices: a first step towards the harmonization of methodologies and tools of different Countries sharing similar problems. Finally, through wide

  6. Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics.

    PubMed

    Fiume, Monice M; Heldreth, Bart; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Andersen, F Alan

    2016-07-01

    The Cosmetic Ingredient Review Expert Panel assessed the safety of 34 microbial polysaccharide gums for use in cosmetics, finding that these ingredients are safe in cosmetic formulations in the present practices of use and concentration. The microbial polysaccharide gums named in this report have a variety of reported functions in cosmetics, including emulsion stabilizer, film former, binder, viscosity-increasing agent, and skin-conditioning agent. The Panel reviewed available animal and clinical data in making its determination of safety. PMID:27383198

  7. International Harmonization of Food Safety Assessment of Pesticide Residues.

    PubMed

    Ambrus, Árpád

    2016-01-13

    This paper summarizes the development of principles and methods applied within the program of the FAO/WHO Codex Alimentarius during the past 50 years for the safety assessment of pesticide residues in food and feed and establishing maximum residue limits (MRLs) to promote free international trade and assure the safety of consumers. The role of major international organizations in this process, the FAO capacity building activities, and some problematic areas that require special attention are briefly described. PMID:25660755

  8. Safety Assessment of Galactomannans as Used in Cosmetics.

    PubMed

    Johnson, Wilbur; Heldreth, Bart; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Andersen, F Alan

    2015-01-01

    The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of 16 galactomannans as used in cosmetics. These ingredients are legume polysaccharides that function mostly as hair/skin-conditioning agents and viscosity-increasing agents in cosmetic products. Their substantial molecular sizes suggest that skin penetration of these ingredients would be unlikely. The Panel concluded that these galactomannans are safe in the present practices of use and concentration described in this safety assessment. PMID:26227890

  9. Initial development of a practical safety audit tool to assess fleet safety management practices.

    PubMed

    Mitchell, Rebecca; Friswell, Rena; Mooren, Lori

    2012-07-01

    Work-related vehicle crashes are a common cause of occupational injury. Yet, there are few studies that investigate management practices used for light vehicle fleets (i.e. vehicles less than 4.5 tonnes). One of the impediments to obtaining and sharing information on effective fleet safety management is the lack of an evidence-based, standardised measurement tool. This article describes the initial development of an audit tool to assess fleet safety management practices in light vehicle fleets. The audit tool was developed by triangulating information from a review of the literature on fleet safety management practices and from semi-structured interviews with 15 fleet managers and 21 fleet drivers. A preliminary useability assessment was conducted with 5 organisations. The audit tool assesses the management of fleet safety against five core categories: (1) management, systems and processes; (2) monitoring and assessment; (3) employee recruitment, training and education; (4) vehicle technology, selection and maintenance; and (5) vehicle journeys. Each of these core categories has between 1 and 3 sub-categories. Organisations are rated at one of 4 levels on each sub-category. The fleet safety management audit tool is designed to identify the extent to which fleet safety is managed in an organisation against best practice. It is intended that the audit tool be used to conduct audits within an organisation to provide an indicator of progress in managing fleet safety and to consistently benchmark performance against other organisations. Application of the tool by fleet safety researchers is now needed to inform its further development and refinement and to permit psychometric evaluation. PMID:22342958

  10. Need for an "integrated safety assessment" of GMOs, linking food safety and environmental considerations.

    PubMed

    Haslberger, Alexander G

    2006-05-01

    Evidence for substantial environmental influences on health and food safety comes from work with environmental health indicators which show that agroenvironmental practices have direct and indirect effects on human health, concluding that "the quality of the environment influences the quality and safety of foods" [Fennema, O. Environ. Health Perspect. 1990, 86, 229-232). In the field of genetically modified organisms (GMOs), Codex principles have been established for the assessment of GM food safety and the Cartagena Protocol on Biosafety outlines international principles for an environmental assessment of living modified organisms. Both concepts also contain starting points for an assessment of health/food safety effects of GMOs in cases when the environment is involved in the chain of events that could lead to hazards. The environment can act as a route of unintentional entry of GMOs into the food supply, such as in the case of gene flow via pollen or seeds from GM crops, but the environment can also be involved in changes of GMO-induced agricultural practices with relevance for health/food safety. Examples for this include potential regional changes of pesticide uses and reduction in pesticide poisonings resulting from the use of Bt crops or influences on immune responses via cross-reactivity. Clearly, modern methods of biotechnology in breeding are involved in the reasons behind the rapid reduction of local varieties in agrodiversity, which constitute an identified hazard for food safety and food security. The health/food safety assessment of GM foods in cases when the environment is involved needs to be informed by data from environmental assessment. Such data might be especially important for hazard identification and exposure assessment. International organizations working in these areas will very likely be needed to initiate and enable cooperation between those institutions responsible for the different assessments, as well as for exchange and analysis of