Science.gov

Sample records for scintillating guides screen

  1. Composite scintillator screen

    DOEpatents

    Zeman, Herbert D.

    1994-01-01

    A scintillator screen for an X-ray system includes a substrate of low-Z material and bodies of a high-Z material embedded within the substrate. By preselecting the size of the bodies embedded within the substrate, the spacial separation of the bodies and the thickness of the screen, the sensitivity of the screen to X-rays within a predetermined energy range can be predicted.

  2. Absolute charge calibration of scintillating screens for relativistic electron detection

    SciTech Connect

    Buck, A.; Popp, A.; Schmid, K.; Karsch, S.; Krausz, F.; Zeil, K.; Jochmann, A.; Kraft, S. D.; Sauerbrey, R.; Cowan, T.; Schramm, U.; Hidding, B.; Kudyakov, T.; Sears, C. M. S.; Veisz, L.; Pawelke, J.

    2010-03-15

    We report on new charge calibrations and linearity tests with high-dynamic range for eight different scintillating screens typically used for the detection of relativistic electrons from laser-plasma based acceleration schemes. The absolute charge calibration was done with picosecond electron bunches at the ELBE linear accelerator in Dresden. The lower detection limit in our setup for the most sensitive scintillating screen (KODAK Biomax MS) was 10 fC/mm{sup 2}. The screens showed a linear photon-to-charge dependency over several orders of magnitude. An onset of saturation effects starting around 10-100 pC/mm{sup 2} was found for some of the screens. Additionally, a constant light source was employed as a luminosity reference to simplify the transfer of a one-time absolute calibration to different experimental setups.

  3. Absolute charge calibration of scintillating screens for relativistic electron detection

    NASA Astrophysics Data System (ADS)

    Buck, A.; Zeil, K.; Popp, A.; Schmid, K.; Jochmann, A.; Kraft, S. D.; Hidding, B.; Kudyakov, T.; Sears, C. M. S.; Veisz, L.; Karsch, S.; Pawelke, J.; Sauerbrey, R.; Cowan, T.; Krausz, F.; Schramm, U.

    2010-03-01

    We report on new charge calibrations and linearity tests with high-dynamic range for eight different scintillating screens typically used for the detection of relativistic electrons from laser-plasma based acceleration schemes. The absolute charge calibration was done with picosecond electron bunches at the ELBE linear accelerator in Dresden. The lower detection limit in our setup for the most sensitive scintillating screen (KODAK Biomax MS) was 10 fC/mm2. The screens showed a linear photon-to-charge dependency over several orders of magnitude. An onset of saturation effects starting around 10-100 pC/mm2 was found for some of the screens. Additionally, a constant light source was employed as a luminosity reference to simplify the transfer of a one-time absolute calibration to different experimental setups.

  4. Screen Study Guides.

    ERIC Educational Resources Information Center

    Duncan, Barry

    1969-01-01

    This study guide for Arthur Lipsett's film "Very Nice, Very Nice" is in four parts. First, it describes and evaluates the film, discusses Lipsett's unusual juxtapositions, fast cutting, and fragmented speeches as indications of his satirical intent, and suggests that the only meaningful summation of the film's content is through pattern…

  5. Optimization of screening for radioactivity in urine by liquid scintillation.

    SciTech Connect

    Shanks, Sonoya Toyoko; Reese, Robert P.; Preston, Rose T.

    2007-08-01

    Numerous events have or could have resulted in the inadvertent uptake of radionuclides by fairly large populations. Should a population receive an uptake, valuable information could be obtained by using liquid scintillation counting (LSC) techniques to quickly screen urine from a sample of the affected population. This study investigates such LSC parameters as discrimination, quench, volume, and count time to yield guidelines for analyzing urine in an emergency situation. Through analyzing variations of the volume and their relationships to the minimum detectable activity (MDA), the optimum ratio of sample size to scintillating chemical cocktail was found to be 1:3. Using this optimum volume size, the alpha MDA varied from 2100 pCi/L for a 30-second count time to 35 pCi/L for a 1000-minute count time. The typical count time used by the Sandia National Laboratories Radiation Protection Sample Diagnostics program is 30 minutes, which yields an alpha MDA of 200 pCi/L. Because MDA is inversely proportional to the square root of the count time, count time can be reduced in an emergency situation to achieve the desired MDA or response time. Note that approximately 25% of the response time is used to prepare the samples and complete the associated paperwork. It was also found that if the nuclide of interest is an unknown, pregenerated discriminator settings and efficiency calibrations can be used to produce an activity value within a factor of two, which is acceptable for a screening method.

  6. High quantum efficiency megavoltage imaging with thick scintillator detectors for image guided radiation therapy

    NASA Astrophysics Data System (ADS)

    Gopal, Arun

    In image guided radiation therapy (IGRT), imaging devices serve as guidance systems to aid patient set-up and tumor volume localization. Traditionally, 2-D megavoltage x-ray imagers, referred to as electronic portal imaging devices (EPIDs), have been used for planar target localization, and have recently been extended to perform 3-D volumetric reconstruction via cone-beam computed tomography (CBCT). However, current EPIDs utilize thin and inefficient phosphor screen detectors and are subsequently limited by poor soft tissue visualization, which limits their use for CBCT. Therefore, the use of thick scintillation media as megavoltage x-ray detectors for greater x-ray sensitivity and enhanced image quality has recently been of significant interest. In this research, two candidates for thick scintillators: CsI(Tl) and terbium doped scintillation glass were investigated in separate imaging configurations. In the first configuration, a thick scintillation crystal (TSC) consisting of a thick, monolithic slab of CsI(Tl) was coupled to a mirror-lens-camera system. The second configuration is based on a fiber-optic scintillation glass array (FOSGA), wherein the scintillation glass is drawn into long fiber-optic conduits, inserted into a grid-type housing constructed out of polymer-tungsten alloy, and coupled to an array of photodiodes for digital read-out. The imaging prototypes were characterized using theoretical studies and imaging measurements to obtain fundamental metrics of imaging performance. Spatial resolution was measured based on a modulation transfer function (MTF), noise was evaluated in terms of a noise power spectrum (NPS), and overall contrast was characterized in the form of detective quantum efficiency (DQE). The imaging studies were used to optimize the TSC and FOSGA imagers and propose prototype configurations for order-of-magnitude improvements in overall image quality. In addition, a fast and simple technique was developed to measure the MTF, NPS, and

  7. New Beginnings: A Guide to Screening.

    ERIC Educational Resources Information Center

    Maine State Dept. of Educational and Cultural Services, Augusta.

    Providing a comprehensive overview, this guide to kindergarten screening was produced to aid Maine's school districts as they work to increase the effectiveness of their screening programs. Part 1, providing materials related to meeting the requirements of Maine's Education Reform Act of 1984, includes regulations pertaining to screening, a…

  8. Combinatorial Screening of Advanced Scintillators for High Resolution X-ray Detectors

    SciTech Connect

    Cheng, Shifan; Tao, Dejie; Lynch, Michael; Yuan, Xianglong; Li, Yiqun

    2008-05-12

    The lack of efficient scintillators is a major problem for developing powerful x-ray detectors that are widely used in homeland security, industrial and scientific research. Intematix has developed and applied a high throughput screening process and corresponding crystal growth technology to significantly speed up the discovery process for new efficient scintillators. As a result, Intematix has invented and fabricated three new scintillators both in powder and bulk forms, which possess promising properties such as better radiation hardness and better matching for silicon diode.

  9. Scintillating screens sensitivity and resolution studies for low energy, low intensity beam diagnostics.

    PubMed

    Harasimowicz, Janusz; Cosentino, Luigi; Finocchiaro, Paolo; Pappalardo, Alfio; Welsch, Carsten P

    2010-10-01

    In order to investigate the limits of scintillating screens for beam profile monitoring in the ultra-low energy, ultra-low intensity regime, CsI:Tl, YAG:Ce, and a Tb glass-based scintillating fiber optic plate (SFOP) were tested. The screens response to 200 and 50 keV proton beams with intensities ranging from a few picoampere down to the subfemtoampere region was examined. In the following paper, the sensitivity and resolution studies are presented in detail for CsI:Tl and the SFOP, the two most sensitive screens. In addition, a possible use of scintillators for ultra-low energy antiproton beam monitoring is discussed. PMID:21034082

  10. Screening and Evaluation Tool (SET) Users Guide

    SciTech Connect

    Layne Pincock

    2014-10-01

    This document is the users guide to using the Screening and Evaluation Tool (SET). SET is a tool for comparing multiple fuel cycle options against a common set of criteria and metrics. It does this using standard multi-attribute utility decision analysis methods.

  11. Ionospheric scintillation by a random phase screen Spectral approach

    NASA Technical Reports Server (NTRS)

    Rufenach, C. L.

    1975-01-01

    The theory developed by Briggs and Parkin, given in terms of an anisotropic gaussian correlation function, is extended to a spectral description specified as a continuous function of spatial wavenumber with an intrinsic outer scale as would be expected from a turbulent medium. Two spectral forms were selected for comparison: (1) a power-law variation in wavenumber with a constant three-dimensional index equal to 4, and (2) Gaussian spectral variation. The results are applied to the F-region ionosphere with an outer-scale wavenumber of 2 per km (approximately equal to the Fresnel wavenumber) for the power-law variation, and 0.2 per km for the Gaussian spectral variation. The power-law form with a small outer-scale wavenumber is consistent with recent F-region in-situ measurements, whereas the gaussian form is mathematically convenient and, hence, mostly used in the previous developments before the recent in-situ measurements. Some comparison with microwave scintillation in equatorial areas is made.

  12. Single electron response of the scintillator-light guide-photomultiplier detector.

    PubMed

    Novák, L; Müllerová, I

    2009-01-01

    The time response of a scintillator-light guide-photomultiplier combination was measured with a time-constant of 3 ns. Single detected electrons were recognizable at the output of the photomultiplier. The distribution of the number of photoelectrons produced by one detected electron and the pulse-height distribution of the photomultiplier output pulses were analysed. Statistical noise computed from these distributions was compared with the noise produced by the dark current of the photomultiplier. PMID:19196414

  13. Arrays of Segmented, Tapered Light Guides for Use with Large, Planar Scintillation Detectors

    PubMed Central

    Raylman, Raymond R.; Vaigneur, Keith; Stolin, Alexander V.; Jaliparthi, Gangadhar

    2015-01-01

    Metabolic imaging techniques can potentially improve detection and diagnosis of cancer in women with radiodense and/or fibrocystic breasts. Our group has previously developed a high-resolution positron emission tomography imaging and biopsy device (PEM-PET) to detect and guide the biopsy of suspicious breast lesions. Initial testing revealed that the imaging field-of-view (FOV) of the scanner was smaller than the physical size of the detector’s active area, which could hinder sampling of breast areas close to the chest wall. The purpose of this work was to utilize segmented, tapered light guides for optically coupling the scintillator arrays to arrays of position-sensitive photomultipliers to increase both the active FOV and identification of individual scintillator elements. Testing of the new system revealed that the optics of these structures made it possible to discern detector elements from the complete active area of the detector face. In the previous system the top and bottom rows and left and right columns were not identifiable. Additionally, use of the new light guides increased the contrast of individual detector elements by up to 129%. Improved element identification led to a spatial resolution increase by approximately 12%. Due to attenuation of light in the light guides the detector energy resolution decreased from 18.5% to 19.1%. Overall, these improvements should increase the field-of-view and spatial resolution of the dedicated breast-PET system. PMID:26538685

  14. Fabrication and characterization of pixelated Gd2O2S:Tb scintillator screens for digital X-ray imaging applications

    NASA Astrophysics Data System (ADS)

    Kim, Jongyul; Kyoung Cha, Bo; Hyung Bae, Jun; Lee, Chae-Hun; Kim, Hyungtaek; Chang, Sungho; Cho, Gyuseong; Sim, Cheulmuu; Kim, Taejoo

    2011-05-01

    X-ray imaging detectors in combination with scintillator screens have been widely used in digital X-ray imaging applications. Gd2O2S:Tb was used as scintillation material for pixelated scintillator screens based on silicon substrates (wafer) with a micropore array of various dimensions fabricated using the photolithography and deep reactive ion etching (DRIE) process. The relative light output and the modulation transfer function (MTF) of each fabricated scintillator screen were measured by a cooled CCD and compared with those of Lanex screens. The spatial resolution of our scintillator screens was higher but their light outputs were lower than those of Lanex screen probably due to the loss of light at the wall surfaces. Therefore further treatment of the wall surface, such as reflective coating, seems necessary to compensate the light loss.

  15. Polycrystalline para-terphenyl scintillator adopted in a β- detecting probe for radio-guided surgery

    NASA Astrophysics Data System (ADS)

    Solfaroli Camillocci, E.; Bellini, F.; Bocci, V.; Collamati, F.; De Lucia, E.; Faccini, R.; Marafini, M.; Mattei, I.; Morganti, S.; Paramatti, R.; Patera, V.; Pinci, D.; Recchia, L.; Russomando, A.; Sarti, A.; Sciubba, A.; Senzacqua, M.; Voena, C.

    2015-06-01

    A radio-guided surgery technique exploiting β- emitters is under development. It aims at a higher target-to-background activity ratio implying both a smaller radiopharmaceutical activity and the possibility of extending the technique to cases with a large uptake of surrounding healthy organs. Such technique requires a dedicated intraoperative probe detecting β- radiation. A first prototype has been developed relying on the low density and high light yield of the diphenylbutadiene doped para-therphenyl organic scintillator. The scintillation light produced in a cylindrical crystal, 5 mm in diameter and 3 mm in height, is guided to a photo-multiplier tube by optical fibres. The custom readout electronics is designed to optimize its usage in terms of feedback to the surgeon, portability and remote monitoring of the signal. Tests show that with a radiotracer activity comparable to those administered for diagnostic purposes the developed probe can detect a 0.1 ml cancerous residual of meningioma in a few seconds.

  16. Inverted-conical light guide for crosstalk reduction in tightly-packed scintillator matrix and MAPMT assembly

    NASA Astrophysics Data System (ADS)

    Chang, Y.-Y.; Chen, C. R.; Chen, P.; Huang, J.-J.; Huang, M. A.; Liu, T.-C.; Nam, J. W.; Wang, M.-Z.; Bogomolov, V.; Brandt, S.; Budtz-Jørgensen, C.; Castro-Tirado, A. J.; Choi, H. S.; Connell, P. H.; Eyles, C.; Jeong, S.; Kim, J. E.; Kim, M. B.; Kim, S.-W.; Lee, J.; Lim, H.; Min, K. W.; Panasyuk, M. I.; Park, I. H.; Petrov, V.; Reglero, V.; Řípa, J.; Rodrigo, J. M.; Svertilov, S.; Yashin, I.

    2015-01-01

    In this paper we present the Inverted-Conical light guide designed for optical crosstalk reduction in the scintillator-MAPMT assemblies. The research was motivated by the 30% crosstalk observed in UFFO X-ray telescope, UBAT, during the preliminary calibration with MAPMTs of 64 2.88 × 2.88 mm2 pixels and identically gridded YSO crystal matrices. We began the study with the energy and crosstalk calibrations of the detector, then we constructed a GEANT4 simulation with the customized metallic film model as the MAPMT photocathode. The simulation reproduced more than 70% of the crosstalk and explained it as a consequence of the total reflection produced by the photocathode. The result indicated that the crosstalk mechanism could be a common case in most of the contact-assembled scintillation detectors. The concept of the Inverted-Conical light guide was to suppress the total reflection by contracting the incident angle of the scintillation. We optimized the design in the simulation and fabricated a test sample. The test sample reduced 52% crosstalk with a loss of 6% signal yield. The idea of the Inverted-Conical light guide can be adapted by scintillation detectors multi-pixel, imaging-purpose scintillation detectors such as the ultra-fast GRB observatory UFFO-UBAT, whose performances are sensitive to responding time, image resolution, and geometrical modifications.

  17. Soil screening guidance: User`s guide

    SciTech Connect

    1996-04-01

    The Soil Screening Guidance is a tool that the U.S. Environmental Protection Agency (EPA) developed to help standardize and accelerate the evaluation and cleanup of contaminated soils at sites on the National Priorities List (NPL) with future residential land use. This guidance provides a methodology for environmental science/engineering professionals to calculate risk-based, site-specific, soil screening levels (SSLs) for contaminants in soil that may be used to identify areas needing further investigation at NPL sites.

  18. HYDROCARBON SPILL SCREENING MODEL (HSSM) VOLUME 1: USER'S GUIDE

    EPA Science Inventory

    This users guide describes the Hydrocarbon Spill Screening Model (HSSM). The model is intended for simulation of subsurface releases of light nonaqueous phase liquids (LNAPLs). The model consists of separate modules for LNAPL flow through the vadose zone, spreading in the capil...

  19. Short interfering RNA guide strand modifiers from computational screening.

    PubMed

    Onizuka, Kazumitsu; Harrison, Jason G; Ball-Jones, Alexi A; Ibarra-Soza, José M; Zheng, Yuxuan; Ly, Diana; Lam, Walter; Mac, Stephanie; Tantillo, Dean J; Beal, Peter A

    2013-11-13

    Short interfering RNAs (siRNAs) are promising drug candidates for a wide range of targets including those previously considered "undruggable". However, properties associated with the native RNA structure limit drug development, and chemical modifications are necessary. Here we describe the structure-guided discovery of functional modifications for the guide strand 5'-end using computational screening with the high-resolution structure of human Ago2, the key nuclease on the RNA interference pathway. Our results indicate the guide strand 5'-end nucleotide need not engage in Watson-Crick (W/C) H-bonding but must fit the general shape of the 5'-end binding site in MID/PIWI domains of hAgo2 for efficient knockdown. 1,2,3-Triazol-4-yl bases formed from the CuAAC reaction of azides and 1-ethynylribose, which is readily incorporated into RNA via the phosphoramidite, perform well at the guide strand 5'-end. In contrast, purine derivatives with modified Hoogsteen faces or N2 substituents are poor choices for 5'-end modifications. Finally, we identified a 1,2,3-triazol-4-yl base incapable of W/C H-bonding that performs well at guide strand position 12, where base pairing to target was expected to be important. This work expands the repertoire of functional nucleotide analogues for siRNAs. PMID:24152142

  20. Short Interfering RNA Guide Strand Modifiers from Computational Screening

    PubMed Central

    Onizuka, Kazumitsu; Harrison, Jason G.; Ball-Jones, Alexi A.; Ibarra-Soza, José M.; Zheng, Yuxuan; Ly, Diana; Lam, Walter; Mac, Stephanie; Tantillo, Dean J.; Beal, Peter A.

    2013-01-01

    Short interfering RNAs (siRNAs) are promising drug candidates for a wide range of targets including those previously considered “undruggable”. However, properties associated with the native RNA structure limit drug development and chemical modifications are necessary. Here we describe the structure-guided discovery of functional modifications for the guide strand 5’ end using computational screening with the high resolution structure of human Ago2, the key nuclease on the RNA interference pathway. Our results indicate the guide strand 5’-end nucleotide need not engage in Watson-Crick (W/C) H-bonding but must fit the general shape of the 5’-end binding site in MID/PIWI domains of hAgo2 for efficient knockdown. 1,2,3-Triazol-4-yl bases formed from the CuAAC reaction of azides and 1-ethynylribose, which is readily incorporated into RNA via the phosphoramidite, perform well at the guide strand 5’-end. In contrast, purine derivatives with modified Hoogsteen faces or N2 substituents are poor choices for 5’-end modifications. Finally, we identified a 1,2,3-triazol-4-yl base incapable of W/C H-bonding that performs well at guide strand position 12, where base pairing to target was expected to be important. This work expands the repertoire of functional nucleotide analogs for siRNAs. PMID:24152142

  1. New process for screen cutting: water-jet guided laser

    NASA Astrophysics Data System (ADS)

    Perrottet, Delphine; Amorosi, Simone; Richerzhagen, Bernold

    2005-07-01

    Today's OLED manufacturers need high-precision, fast tools to cut the metal screens used to deposit the electroluminescent layers onto the substrate. Conventional methods -tching and dry laser cutting - are not satisfying regarding the demands of high-definition OLED displays. A new micro machining technology, the water jet guided laser - a hybrid of laser and water jet technologies that has been actively used in recent years in the electronic and semiconductor field - is now available to OLED manufacturers. This technology represents a significant improvement in screen, mask and stencil cutting, as it combines high precision and high speed. It is able to cut small apertures with totally clean edges (no dross or slag), as the water jet removes the particles and a thin water film is maintained on the material surface during the process. Because the water jet cools the material between the laser pulses, the cut material is free of any thermal stress. The water jet guided laser is also a very fast process: as an example, rectangular slots can be cut in 30 to 50 microns thick stainless steel or nickel at a rate between 25'000 and 30'000 holes per hour.

  2. Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase.

    PubMed

    Meleza, Cesar; Thomasson, Bobbie; Ramachandran, Chidambaram; O'Neill, Jason W; Michelsen, Klaus; Lo, Mei-Chu

    2016-10-15

    Prostaglandin D2 synthase (PGDS) catalyzes the isomerization of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2). PGD2 produced by hematopoietic prostaglandin D2 synthase (H-PGDS) in mast cells and Th2 cells is proposed to be a mediator of allergic and inflammatory responses. Consequently, inhibitors of H-PGDS represent potential therapeutic agents for the treatment of inflammatory diseases such as asthma. Due to the instability of the PGDS substrate PGH2, an in-vitro enzymatic assay is not feasible for large-scale screening of H-PGDS inhibitors. Herein, we report the development of a competition binding assay amenable to high-throughput screening (HTS) in a scintillation proximity assay (SPA) format. This assay was used to screen an in-house compound library of approximately 280,000 compounds for novel H-PGDS inhibitors. The hit rate of the H-PGDS primary screen was found to be 4%. This high hit rate suggests that the active site of H-PGDS can accommodate a large diversity of chemical scaffolds. For hit prioritization, these initial hits were rescreened at a lower concentration in SPA and tested in the LAD2 cell assay. 116 compounds were active in both assays with IC50s ranging from 6 to 807 nM in SPA and 82 nM to 10 μM in the LAD2 cell assay. PMID:27485270

  3. Experimental validation of Monte Carlo (MANTIS) simulated x-ray response of columnar CsI scintillator screens

    SciTech Connect

    Freed, Melanie; Miller, Stuart; Tang, Katherine; Badano, Aldo

    2009-11-15

    Purpose: MANTIS is a Monte Carlo code developed for the detailed simulation of columnar CsI scintillator screens in x-ray imaging systems. Validation of this code is needed to provide a reliable and valuable tool for system optimization and accurate reconstructions for a variety of x-ray applications. Whereas previous validation efforts have focused on matching of summary statistics, in this work the authors examine the complete point response function (PRF) of the detector system in addition to relative light output values. Methods: Relative light output values and high-resolution PRFs have been experimentally measured with a custom setup. A corresponding set of simulated light output values and PRFs have also been produced, where detailed knowledge of the experimental setup and CsI:Tl screen structures are accounted for in the simulations. Four different screens were investigated with different thicknesses, column tilt angles, and substrate types. A quantitative comparison between the experimental and simulated PRFs was performed for four different incidence angles (0 deg., 15 deg., 30 deg., and 45 deg.) and two different x-ray spectra (40 and 70 kVp). The figure of merit (FOM) used measures the normalized differences between the simulated and experimental data averaged over a region of interest. Results: Experimental relative light output values ranged from 1.456 to 1.650 and were in approximate agreement for aluminum substrates, but poor agreement for graphite substrates. The FOMs for all screen types, incidence angles, and energies ranged from 0.1929 to 0.4775. To put these FOMs in context, the same FOM was computed for 2D symmetric Gaussians fit to the same experimental data. These FOMs ranged from 0.2068 to 0.8029. Our analysis demonstrates that MANTIS reproduces experimental PRFs with higher accuracy than a symmetric 2D Gaussian fit to the experimental data in the majority of cases. Examination of the spatial distribution of differences between the PRFs

  4. Experimental validation of Monte Carlo (MANTIS) simulated x-ray response of columnar CsI scintillator screens

    PubMed Central

    Freed, Melanie; Miller, Stuart; Tang, Katherine; Badano, Aldo

    2009-01-01

    Purpose:MANTIS is a Monte Carlo code developed for the detailed simulation of columnar CsI scintillator screens in x-ray imaging systems. Validation of this code is needed to provide a reliable and valuable tool for system optimization and accurate reconstructions for a variety of x-ray applications. Whereas previous validation efforts have focused on matching of summary statistics, in this work the authors examine the complete point response function (PRF) of the detector system in addition to relative light output values. Methods: Relative light output values and high-resolution PRFs have been experimentally measured with a custom setup. A corresponding set of simulated light output values and PRFs have also been produced, where detailed knowledge of the experimental setup and CsI:Tl screen structures are accounted for in the simulations. Four different screens were investigated with different thicknesses, column tilt angles, and substrate types. A quantitative comparison between the experimental and simulated PRFs was performed for four different incidence angles (0°, 15°, 30°, and 45°) and two different x-ray spectra (40 and 70 kVp). The figure of merit (FOM) used measures the normalized differences between the simulated and experimental data averaged over a region of interest. Results: Experimental relative light output values ranged from 1.456 to 1.650 and were in approximate agreement for aluminum substrates, but poor agreement for graphite substrates. The FOMs for all screen types, incidence angles, and energies ranged from 0.1929 to 0.4775. To put these FOMs in context, the same FOM was computed for 2D symmetric Gaussians fit to the same experimental data. These FOMs ranged from 0.2068 to 0.8029. Our analysis demonstrates that MANTIS reproduces experimental PRFs with higher accuracy than a symmetric 2D Gaussian fit to the experimental data in the majority of cases. Examination of the spatial distribution of differences between the PRFs shows that the

  5. Characterization of the SIDDHARTA-2 second level trigger detector prototype based on scintillators coupled to a prism reflector light guide

    NASA Astrophysics Data System (ADS)

    Bazzi, M.; Berucci, C.; Curceanu, C.; d'Uffizi, A.; Iliescu, M.; Sbardella, E.; Scordo, A.; Shi, H.; Sirghi, F.; Tatsuno, H.; Tucakovic, I.

    2013-11-01

    The SIDDHARTA experiment at the DAΦNE collider of LNF-INFN performed in 2009 high precision measurements of kaonic hydrogen and kaonic helium atomic transitions. To determine the bar KN isospin dependent scattering lenghts an important measurement, namely the kaonic deuterium one, is, however, still missing. Due to the very low expected yield of the kaonic deuterium Kα transition, a major improvement in the signal over background ratio is needed. To achieve a further background reduction, a second level trigger, based on the detection of charged pions produced by the K- absorption on various materials, including the target gas nuclei, is planned to be implemented in the future SIDDHARTA-2 experiment. For shielding-related geometrical limitations, a single side of the scintillators can be accessed; in order to reach a good time resolution and uniform efficiency, a both-end readout was then realized with complex multi-reflection light guides. In this work, the results of the tests made on a detector prototype, performed on the πM-1 beamline of the Paul Scherrer Institute (Switzerland), are presented. The tests had the goal to determine the efficiency and the time resolution for pions, which should comply with the minimum required values of 90% and 1 ns (FWHM) respectively. The obtained results, 96% efficiency and 750 ps FWHM for 170 MeV/c momentum pions, qualify the prototype as an excellent second level trigger for the SIDDHARTA-2 experiment. Similar results for 170 MeV/c momentum muons and electrons are also presented.

  6. USER S GUIDE FOR THE RANDOM DRUG SCREENING SYSTEM

    SciTech Connect

    McNeany, Karen I

    2013-12-01

    The Random Drug Screening System (RDSS) is a desktop computing application designed to assign nongameable drug testing dates to each member in a population of employees, within a specific time line. The program includes reporting capabilities, test form generation, unique test ID number assignment, and the ability to flag high-risk employees for a higher frequency of drug testing than the general population.

  7. Hazard screening application guide. Safety Analysis Report Update Program

    SciTech Connect

    1992-06-01

    The basic purpose of hazard screening is to group precesses, facilities, and proposed modifications according to the magnitude of their hazards so as to determine the need for and extent of follow on safety analysis. A hazard is defined as a material, energy source, or operation that has the potential to cause injury or illness in human beings. The purpose of this document is to give guidance and provide standard methods for performing hazard screening. Hazard screening is applied to new and existing facilities and processes as well as to proposed modifications to existing facilities and processes. The hazard screening process evaluates an identified hazards in terms of the effects on people, both on-site and off-site. The process uses bounding analyses with no credit given for mitigation of an accident with the exception of certain containers meeting DOT specifications. The process is restricted to human safety issues only. Environmental effects are addressed by the environmental program. Interfaces with environmental organizations will be established in order to share information.

  8. Structured clinical interview guide for postdeployment psychological screening programs.

    PubMed

    Wright, Kathleen M; Adler, Amy B; Bliese, Paul D; Eckford, Rachel D

    2008-05-01

    Brief structured clinical interviews are a key component of the Department of Defense postdeployment health reassessment program. Such interviews are critical for recommending individuals for follow-up assessment and care. To standardize the interview process, U.S. Army Medical Research Unit-Europe developed a structured interview guide, designed in response to both clinical requirements and research findings. The guide includes sections on depression, suicidality, post-traumatic stress disorder, anger, relationship problems, alcohol problems, and sleep problems. In addition, there is an open-ended section on other problems and a section for case dispositions. Data from a 2005 blinded validation study with soldiers returning from a 1-year-long combat deployment are included to demonstrate the utility of the structured interview. Guidelines and implementation considerations for the use of the structured interview are discussed. PMID:18543560

  9. Simulating the effects of scintillation on transionospheric signals with a two-way phase screen constructed from ALTAIR phase-derived TEC

    NASA Astrophysics Data System (ADS)

    Caton, R. G.; Carrano, C. S.; Alcala, C. M.; Groves, K. M.; Beach, T.; Sponseller, D.

    2009-02-01

    Severe scintillation on transionospheric radio signals caused by small-scale plasma irregularities can greatly disrupt wideband communication, surveillance, and navigation systems. Development of techniques to mitigate the effects of scintillation requires accurate characterization of the ionospheric propagation channel. To achieve this goal, multiple campaigns were conducted as part of the joint U.S. -UK Wideband Ionospheric Distortion Experiment to obtain ionospheric signatures from various instruments located on Kwajalein Atoll. We use tracking data from the VHF/UHF Advanced Research Project Agency Long-Range Tracking and Instrumentation Radar for overflights of passive calibration spheres in low-Earth orbit to demonstrate the validity of a one-dimensional (1-D) phase screen model to represent the propagation channel through a disturbed ionosphere. The 1-D phase screen is constructed from radar phase-derived estimates of the total electron content. We present a detailed comparison of simulated radar cross section after propagation through the phase screen with observed radar returns under both disturbed and quiet ionospheric conditions. Successful reproduction of radar amplitude enhancements and fades adds to our understanding of small-scale plasma irregularities and moves us toward our goal of providing precise predictions of radar system performance. Doing so will allow for the development of better mitigation/compensation algorithms for detrimental ionospheric effects. Result from this study also provide an assessment of the tools required for incorporating in situ density measurements along with phase screen theory into situational awareness products to offer an accurate nowcast/forecast of system impacts to users in the communication, navigation, and surveillance communities.

  10. Protein Ligand Complex Guided Approach for Virtual Screening.

    PubMed

    Karthikeyan, Muthukumarasamy; Pandit, Deepak; Vyas, Renu

    2015-01-01

    The target ligand association data is a rich source of information which is not exploited enough for drug design efforts in virtual screening. A java based open-source toolkit for Protein Ligand Network Extraction (J-ProLiNE) focused on protein-ligand complex analysis with several features integrated in a distributed computing network has been developed. Sequence alignment and similarity search components have been automated to yield local, global alignment scores along with similarity and distance scores. 10000 proteins with co-crystallized ligands from pdb and MOAD databases were extracted and analyzed for revealing relationships between targets, ligands and scaffolds. Through this analysis, we could generate a protein ligand network to identify the promiscuous and selective scaffolds for multiple classes of proteins targets. Using J-ProLiNE we created a 507 x 507 matrix of protein targets and native ligands belonging to six enzyme classes and analyzed the results to elucidate the protein-protein, protein-ligand and ligand-ligand interactions. In yet another application of the J-ProLiNE software, we were able to process kinase related information stored in US patents to construct disease-gene-ligand-scaffold networks. It is hoped that the studies presented here will enable target ligand knowledge based virtual screening for inhibitor design. PMID:26138572

  11. On the response of Y 3Al 5O 12: Ce (YAG: Ce) powder scintillating screens to medical imaging X-rays

    NASA Astrophysics Data System (ADS)

    Kandarakis, I.; Cavouras, D.; Sianoudis, I.; Nikolopoulos, D.; Episkopakis, A.; Linardatos, D.; Margetis, D.; Nirgianaki, E.; Roussou, M.; Melissaropoulos, P.; Kalivas, N.; Kalatzis, I.; Kourkoutas, K.; Dimitropoulos, N.; Louizi, A.; Nomicos, C.; Panayiotakis, G.

    2005-02-01

    The aim of this study was to examine Y 3Al 5O 12:Ce (also known as YAG:Ce) powder scintillator under X-ray imaging conditions. This material shows a very fast scintillation decay time and it has never been used in X-ray medical imaging. In the present study various scintillator layers (screens) with coating thickness ranging from 13 to 166 mg/cm 2 were prepared in our laboratory by sedimentation of Y 3Al 5O 12: Ce powder. Optical emission spectra and light emission efficiency (spectrum area over X-ray exposure) of the layers were measured under X-ray excitation using X-ray tube voltages (80-120 kVp) often employed in general medical radiography and fluoroscopy. Spectral compatibility with various optical photon detectors (photodiodes, photocathodes, charge coupled devices, films) and intrinsic conversion efficiency values were determined using emission spectrum data. In addition, parameters related to X-ray detection, energy absorption efficiency and K-fluorescence characteristic emission were calculated. A theoretical model describing radiation and light transfer through scattering media was used to fit experimental data. Intrinsic conversion efficiency (η≈0.03-0.05) and light attenuation coefficients (σ≈26.5 cm/g) were derived through this fitting. Y 3Al 5O 12:Ce showed peak emission in the wavelength range 530-550 nm. The light emission efficiency was found to be maximum for the 107 mg/cm 2 layer. Due to its "green" emission spectrum, Y 3Al 5O 12:Ce showed excellent compatibility (of the order of 0.9) with the sensitivity of many currently used photodetectors. Taking into account its very fast response Y 3Al 5O 12:Ce could be considered for application in X-ray imaging especially in various digital detectors.

  12. Large-Scale Single-Guide RNA Library Construction and Use for Genetic Screens

    PubMed Central

    Wang, Tim; Lander, Eric S.; Sabatini, David M.

    2016-01-01

    The ability to systematically disrupt genes serves as a powerful tool for understanding their function. The programmable Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system enables efficient targeting of large numbers of genes through the use of single-guide RNA (sgRNA) libraries. In cultured mammalian cells, collections of knockout mutants can be readily generated via transduction of Cas9/sgRNA lentiviral pools, screened for a phenotype of interest, and tracked using high-throughput DNA sequencing. This technique represents the first general method for undertaking systematic loss-of-function genetic screens in mammalian cells. In this chapter, we outline the steps for conducting CRISPR-based screens from the initial library design to final data analysis and provide guidelines for developing an appropriate screening strategy. PMID:26933254

  13. Experimental study of heavy-ion computed tomography using a scintillation screen and an electron-multiplying charged coupled device camera for human head imaging

    NASA Astrophysics Data System (ADS)

    Muraishi, Hiroshi; Hara, Hidetake; Abe, Shinji; Yokose, Mamoru; Watanabe, Takara; Takeda, Tohoru; Koba, Yusuke; Fukuda, Shigekazu

    2016-03-01

    We have developed a heavy-ion computed tomography (IonCT) system using a scintillation screen and an electron-multiplying charged coupled device (EMCCD) camera that can measure a large object such as a human head. In this study, objective with the development of the system was to investigate the possibility of applying this system to heavy-ion treatment planning from the point of view of spatial resolution in a reconstructed image. Experiments were carried out on a rotation phantom using 12C accelerated up to 430 MeV/u by the Heavy-Ion Medical Accelerator in Chiba (HIMAC) at the National Institute of Radiological Sciences (NIRS). We demonstrated that the reconstructed image of an object with a water equivalent thickness (WET) of approximately 18 cm was successfully achieved with the spatial resolution of 1 mm, which would make this IonCT system worth applying to the heavy-ion treatment planning for head and neck cancers.

  14. Measurement of transmission efficiency for 400 MeV proton beam through collimator at Fermilab MuCool Test Area using Chromox-6 scintillation screen

    SciTech Connect

    Jana, M. R.; Chung, M.; Leonova, M.; Moretti, A.; Palmer, M.; Schwarz, T.; Tollestrup, A.; Yonehara, K.; Freemire, B.; Hanlet, P.; Torun, Y.

    2013-06-15

    The MuCool Test Area (MTA) at Fermilab is a facility to develop the technology required for ionization cooling for a future Muon Collider and/or Neutrino Factory. As part of this research program, feasibility studies of various types of RF cavities in a high magnetic field environment are in progress. As a unique approach, we have tested a RF cavity filled with a high pressure hydrogen gas with a 400 MeV proton beam in an external magnetic field (B = 3 T). Quantitative information about the number of protons passing through this cavity is an essential requirement of the beam test. The MTA is a flammable gas (hydrogen) hazard zone. Due to safety reasons, no active (energized) beam diagnostic instrument can be used. Moreover, when the magnetic field is on, current transformers (toroids) used for beam intensity measurements do not work due to the saturation of the ferrite material of the transformer. Based on these requirements, we have developed a passive beam diagnostic instrumentation using a combination of a Chromox-6 scintillation screen and CCD camera. This paper describes details of the beam profile and position obtained from the CCD image with B = 0 T and B = 3 T, and for high and low intensity proton beams. A comparison is made with beam size obtained from multi-wires detector. Beam transmission efficiency through a collimator with a 4 mm diameter hole is measured by the toroids and CCD image of the scintillation screen. Results show that the transmission efficiency estimated from the CCD image is consistent with the toroid measurement, which enables us to monitor the beam transmission efficiency even in a high magnetic field environment.

  15. Measurement of transmission efficiency for 400 MeV proton beam through collimator at Fermilab MuCool Test Area using Chromox-6 scintillation screen.

    PubMed

    Jana, M R; Chung, M; Freemire, B; Hanlet, P; Leonova, M; Moretti, A; Palmer, M; Schwarz, T; Tollestrup, A; Torun, Y; Yonehara, K

    2013-06-01

    The MuCool Test Area (MTA) at Fermilab is a facility to develop the technology required for ionization cooling for a future Muon Collider and∕or Neutrino Factory. As part of this research program, feasibility studies of various types of RF cavities in a high magnetic field environment are in progress. As a unique approach, we have tested a RF cavity filled with a high pressure hydrogen gas with a 400 MeV proton beam in an external magnetic field (B = 3 T). Quantitative information about the number of protons passing through this cavity is an essential requirement of the beam test. The MTA is a flammable gas (hydrogen) hazard zone. Due to safety reasons, no active (energized) beam diagnostic instrument can be used. Moreover, when the magnetic field is on, current transformers (toroids) used for beam intensity measurements do not work due to the saturation of the ferrite material of the transformer. Based on these requirements, we have developed a passive beam diagnostic instrumentation using a combination of a Chromox-6 scintillation screen and CCD camera. This paper describes details of the beam profile and position obtained from the CCD image with B = 0 T and B = 3 T, and for high and low intensity proton beams. A comparison is made with beam size obtained from multi-wires detector. Beam transmission efficiency through a collimator with a 4 mm diameter hole is measured by the toroids and CCD image of the scintillation screen. Results show that the transmission efficiency estimated from the CCD image is consistent with the toroid measurement, which enables us to monitor the beam transmission efficiency even in a high magnetic field environment. PMID:23822337

  16. Measurement of transmission efficiency for 400 MeV proton beam through collimator at Fermilab MuCool Test Area using Chromox-6 scintillation screen

    NASA Astrophysics Data System (ADS)

    Jana, M. R.; Chung, M.; Freemire, B.; Hanlet, P.; Leonova, M.; Moretti, A.; Palmer, M.; Schwarz, T.; Tollestrup, A.; Torun, Y.; Yonehara, K.

    2013-06-01

    The MuCool Test Area (MTA) at Fermilab is a facility to develop the technology required for ionization cooling for a future Muon Collider and/or Neutrino Factory. As part of this research program, feasibility studies of various types of RF cavities in a high magnetic field environment are in progress. As a unique approach, we have tested a RF cavity filled with a high pressure hydrogen gas with a 400 MeV proton beam in an external magnetic field (B = 3 T). Quantitative information about the number of protons passing through this cavity is an essential requirement of the beam test. The MTA is a flammable gas (hydrogen) hazard zone. Due to safety reasons, no active (energized) beam diagnostic instrument can be used. Moreover, when the magnetic field is on, current transformers (toroids) used for beam intensity measurements do not work due to the saturation of the ferrite material of the transformer. Based on these requirements, we have developed a passive beam diagnostic instrumentation using a combination of a Chromox-6 scintillation screen and CCD camera. This paper describes details of the beam profile and position obtained from the CCD image with B = 0 T and B = 3 T, and for high and low intensity proton beams. A comparison is made with beam size obtained from multi-wires detector. Beam transmission efficiency through a collimator with a 4 mm diameter hole is measured by the toroids and CCD image of the scintillation screen. Results show that the transmission efficiency estimated from the CCD image is consistent with the toroid measurement, which enables us to monitor the beam transmission efficiency even in a high magnetic field environment.

  17. Scintillator material

    DOEpatents

    Anderson, David F.; Kross, Brian J.

    1994-01-01

    An improved scintillator material comprising cerium fluoride is disclosed. Cerium fluoride has been found to provide a balance of good stopping power, high light yield and short decay constant that is superior to known scintillator materials such as thallium-doped sodium iodide, barium fluoride and bismuth germanate. As a result, cerium fluoride is favorably suited for use as a scintillator material in positron emission tomography.

  18. Scintillator material

    DOEpatents

    Anderson, D.F.; Kross, B.J.

    1992-07-28

    An improved scintillator material comprising cerium fluoride is disclosed. Cerium fluoride has been found to provide a balance of good stopping power, high light yield and short decay constant that is superior to known scintillator materials such as thallium-doped sodium iodide, barium fluoride and bismuth germanate. As a result, cerium fluoride is favorably suited for use as a scintillator material in positron emission tomography. 4 figs.

  19. Scintillator material

    DOEpatents

    Anderson, D.F.; Kross, B.J.

    1994-06-07

    An improved scintillator material comprising cerium fluoride is disclosed. Cerium fluoride has been found to provide a balance of good stopping power, high light yield and short decay constant that is superior to known scintillator materials such as thallium-doped sodium iodide, barium fluoride and bismuth germanate. As a result, cerium fluoride is favorably suited for use as a scintillator material in positron emission tomography. 4 figs.

  20. Scintillator material

    DOEpatents

    Anderson, David F.; Kross, Brian J.

    1992-01-01

    An improved scintillator material comprising cerium fluoride is disclosed. Cerium fluoride has been found to provide a balance of good stopping power, high light yield and short decay constant that is superior to known scintillator materials such as thallium-doped sodium iodide, barium fluoride and bismuth germanate. As a result, cerium fluoride is favorably suited for use as a scintillator material in positron emission tomography.

  1. A Guide for Developing Standard Operating Job Procedures for the Screening & Grinding Process Wastewater Treatment Facility. SOJP No. 1.

    ERIC Educational Resources Information Center

    Deal, Gerald A.; Montgomery, James A.

    This guide describes standard operating job procedures for the screening and grinding process of wastewater treatment facilities. The objective of this process is the removal of coarse materials from the raw waste stream for the protection of subsequent equipment and processes. The guide gives step-by-step instructions for safety inspection,…

  2. Imaging performance of a thin Lu2O3:Eu nanophosphor scintillating screen coupled to a high resolution CMOS sensor under X-ray radiographic conditions: comparison with Gd2O2S:Eu conventional phosphor screen

    NASA Astrophysics Data System (ADS)

    Seferis, I.; Michail, C.; Valais, I.; Zeler, J.; Liaparinos, P.; Kalyvas, N.; Fountos, G.; Zych, E.; Kandarakis, I.; Panayiotakis, G.

    2014-03-01

    The purpose of the present study was to experimentally evaluate the imaging characteristics of the Lu2O3:Eu nanophosphor thin screen coupled to a high resolution CMOS sensor under radiographic conditions. Parameters such as the Modulation Transfer Function (MTF), the Normalized Noise Power Spectrum (NNPS) and the Detective Quantum Efficiency (DQE) were investigated at 70 kVp under three exposure levels (20 mAs, 63 mAs and 90 mAs). Since Lu2O3:Eu emits light in the red wavelength range, the imaging characteristics of a 33.3 mg/cm2 Gd2O2S:Eu conventional phosphor screen were also evaluated for comparison purposes. The Lu2O3:Eu nanophosphor powder was produced by the combustion synthesis, using urea as fuel. A scintillating screen of 30.2 mg/cm2 was prepared by sedimentation of the nanophosphor powder on a fused silica substrate. The CMOS/Lu2O3:Eu detector`s imaging characteristics were evaluated using an experimental method proposed by the International Electrotechnical Commission (IEC) guidelines. It was found that the CMOS/Lu2O3:Eu nanophosphor system has higher MTF values compared to the CMOS/Gd2O2S:Eu sensor/screen combination in the whole frequency range examined. For low frequencies (0 to 2 cycles/mm) NNPS values of the CMOS/Gd2O2S:Eu system were found 90% higher compared to the NNPS values of the CMOS/Lu2O3:Eu nanophosphor system, whereas from medium to high frequencies (2 to 13 cycles/mm) were found 40% higher. In contrast with the CMOS/ Gd2O2S:Eu system, CMOS/Lu2O3:Eu nanophosphor system appears to retain high DQE values in the whole frequency range examined. Our results indicate that Lu2O3:Eu nanophosphor is a promising scintillator for further research in digital X-ray radiography.

  3. Molecular Shape Analysis-Guided Virtual Screening Platform for Adenosine Kinase Inhibitors

    PubMed Central

    Bhutoria, Savita; Das, Ballari; Ghoshal, Nanda

    2016-01-01

    We propose a new application of molecular shape descriptors in hierarchical selection during virtual screening (VS). Here, a structure-based pharmacophore and docking-guided VS protocol have been evolved to identify inhibitors against adenosine kinase (AK). The knowledge gained on the shape requirements has been extrapolated in classifying active and inactive molecules against this target. This classification enabled us to pick the appropriate ligand conformation in the binding site. We have suggested a set of hierarchical filters for VS, from a simple molecular shape analysis (MSA) descriptor-based recursive models to docking scores. This approach permits a systematic study to understand the importance of spatial requirements and limitations for inhibitors against AK. Finally, the guidelines on how to select compounds for AK to achieve success have been highlighted. The utility of this approach has been suggested by giving an example of database screening for plausible active compounds. PMID:27478367

  4. A scintillation proximity assay for the Raf/MEK/ERK kinase cascade: high-throughput screening and identification of selective enzyme inhibitors.

    PubMed

    McDonald, O B; Chen, W J; Ellis, B; Hoffman, C; Overton, L; Rink, M; Smith, A; Marshall, C J; Wood, E R

    1999-03-15

    We have developed a quantitative scintillation proximity assay (SPA) that reproduces the Raf/MEK/ERK signal transduction pathway. The components of this assay include human cRaf1, MEK1, and ERK2 and a biotinylated peptide substrate for ERK2. cRaf1 was expressed as a his-tagged protein in insect cells in an active form. MEK1 and ERK2 were expressed in Escherichia coli as glutathione S-transferase (GST)-fusion proteins in their inactive forms. ERK2 was removed from the GST portion of the fusion protein by cleavage with thrombin protease. When the purified components are incubated together, cRaf-1 phosphorylates and activates MEK1, MEK1 phosphorylates and activates ERK2, and ERK2 phosphorylates the peptide, biotin-AAATGPLSPGPFA. Phosphorylation of the peptide using [gamma-33P]ATP is detected following binding to streptavidin-coated SPA beads. The assay detects inhibitors of cRaf1, MEK1, or ERK2, and has been used to screen large numbers of compounds. The specific target of inhibition was subsequently identified with secondary assays described herein. PMID:10075822

  5. A Guided Materials Screening Approach for Developing Quantitative Sol-gel Derived Protein Microarrays

    PubMed Central

    Helka, Blake-Joseph; Brennan, John D.

    2013-01-01

    Microarrays have found use in the development of high-throughput assays for new materials and discovery of small-molecule drug leads. Herein we describe a guided material screening approach to identify sol-gel based materials that are suitable for producing three-dimensional protein microarrays. The approach first identifies materials that can be printed as microarrays, narrows down the number of materials by identifying those that are compatible with a given enzyme assay, and then hones in on optimal materials based on retention of maximum enzyme activity. This approach is applied to develop microarrays suitable for two different enzyme assays, one using acetylcholinesterase and the other using a set of four key kinases involved in cancer. In each case, it was possible to produce microarrays that could be used for quantitative small-molecule screening assays and production of dose-dependent inhibitor response curves. Importantly, the ability to screen many materials produced information on the types of materials that best suited both microarray production and retention of enzyme activity. The materials data provide insight into basic material requirements necessary for tailoring optimal, high-density sol-gel derived microarrays. PMID:24022739

  6. T & I--Graphic Arts, Silk Screen Printing. Kit No. 60. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Cope, George

    An instructor's manual and student activity guide on silk screen printing are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry (graphic arts). (This set of materials is one of ninety-two prevocational sets arranged around a cluster of seven vocational offerings: agriculture, home…

  7. Shackleton's Antarctic Adventure: The Greatest Survival Story of All Time. Teacher's Guide To Accompany the Giant-Screen Film.

    ERIC Educational Resources Information Center

    Gibb, Reen

    This teacher's guide was developed to accompany the giant-screen film, "Shackleton's Antarctic Adventure". The activities featured use a multidisciplinary approach and target students ages 7 through 14. Teacher pages include background information and student pages include instructions and additional information for understanding the activity.…

  8. Taking It to the Pews: A CBPR-Guided HIV Awareness and Screening Project with Black Churches

    ERIC Educational Resources Information Center

    Berkley-Patton, Jannette; Bowe-Thompson, Carole; Bradley-Ewing, Andrea; Hawes, Starlyn; Moore, Erin; Williams, Eric; Martinez, David; Goggin, Kathy

    2010-01-01

    Utilizing a community-based participatory research (CBPR) approach is a potentially effective strategy for exploring the development, implementation, and evaluation of HIV interventions in African American churches. This CBPR-guided study describes a church-based HIV awareness and screening intervention (Taking It to the Pews [TIPS]) that fully…

  9. A Guide to Dental Care for the Early and Periodic Screening, Diagnosis, and Treatment Program (EPSDT) Under Medicaid.

    ERIC Educational Resources Information Center

    Lindahl, Roy L.; Young, Wesley O.

    This guide has been developed to assist administrators, providers of dental care, and others involved in carrying out the dental care provisions of the EPSDT program (Early and Periodic Screening, Diagnosis, and Treatment Program). It is intended to assist in the development of programs concerned with the unique characteristics of dental diseases…

  10. Using adverse outcome pathway analysis to guide development of high-throughput screening assays for thyroid-disruptors

    EPA Science Inventory

    Using Adverse Outcome Pathway Analysis to Guide Development of High-Throughput Screening Assays for Thyroid-Disruptors Katie B. Paul1,2, Joan M. Hedge2, Daniel M. Rotroff4, Kevin M. Crofton4, Michael W. Hornung3, Steven O. Simmons2 1Oak Ridge Institute for Science Education Post...

  11. Incremental Validity Analyses of the Violence Risk Appraisal Guide and the Psychopathy Checklist: Screening Version in a Civil Psychiatric Sample

    ERIC Educational Resources Information Center

    Edens, John F.; Skeem, Jennifer L.; Douglas, Kevin S.

    2006-01-01

    This study compares two instruments frequently used to assess risk for violence, the Violence Risk Appraisal Guide (VRAG) and the Psychopathy Checklist: Screening Version (PCL:SV), in a large sample of civil psychiatric patients. Despite a strong bivariate relationship with community violence, the VRAG could not improve on the predictive validity…

  12. Usefulness of previous methicillin-resistant Staphylococcus aureus screening results in guiding empirical therapy for S aureus bacteremia

    PubMed Central

    Bai, Anthony D; Burry, Lisa; Showler, Adrienne; Steinberg, Marilyn; Ricciuto, Daniel; Fernandes, Tania; Chiu, Anna; Raybardhan, Sumit; Tomlinson, George A; Bell, Chaim M; Morris, Andrew M

    2015-01-01

    BACKGROUND: Staphylococcus aureus bacteremia (SAB) is an important infection. Methicillin-resistant S aureus (MRSA) screening is performed on hospitalized patients for infection control purposes. OBJECTIVE: To assess the usefulness of past MRSA screening for guiding empirical antibiotic therapy for SAB. METHODS: A retrospective cohort study examined consecutive patients with confirmed SAB and previous MRSA screening swab from six academic and community hospitals between 2007 and 2010. Diagnostic test properties were calculated for MRSA screening swab for predicting methicillin resistance of SAB. RESULTS: A total of 799 patients underwent MRSA screening swabs before SAB. Of the 799 patients, 95 (12%) had a positive and 704 (88%) had a negative previous MRSA screening swab. There were 150 (19%) patients with MRSA bacteremia. Overall, previous MRSA screening swabs had a positive likelihood ratio of 33 (95% CI 18 to 60) and a negative likelihood ratio of 0.45 (95% CI 0.37 to 0.54). Diagnostic accuracy differed depending on mode of acquisition (ie, community-acquired, nosocomial or health care-associated infection) (P<0.0001) and hospital (P=0.0002). At best, for health care-associated infection, prior MRSA screening swab had a positive likelihood ratio of 16 (95% CI 9 to 28) and a negative likelihood ratio of 0.27 (95% CI 0.17 to 0.41). CONCLUSIONS: A negative prior MRSA screening swab cannot reliably rule out MRSA bacteremia and should not be used to guide empirical antibiotic therapy for SAB. A positive prior MRSA screening swab greatly increases likelihood of MRSA, necessitating MRSA coverage in empirical antibiotic therapy for SAB. PMID:26361488

  13. A Guide to Screening for the Early and Periodic Screening, Diagnosis and Treatment Program (EPSDT) Under Medicaid.

    ERIC Educational Resources Information Center

    Frankenburg, William K.; North, A. Frederick, Jr.

    The manual was designed to help public officials, physicians, nurses, and others to plan and implement an Early and Periodic Screening, Diagnosis and Treatment (EPSDT) program under Medicaid. Procedures for carrying out components of an EPSDT program are recommended. Part 1 discusses organization and administration of screening, diagnosis, and…

  14. Focused Decision Support: a Data Mining Tool to Query the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Dataset and Guide Screening Management for the Individual Patient.

    PubMed

    Sharma, Arjun; Hostetter, Jason; Morrison, James; Wang, Kenneth; Siegel, Eliot

    2016-04-01

    The Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial enrolled ~155,000 participants to determine whether certain screening exams reduced mortality from prostate, lung, colorectal, and ovarian cancer. Repurposing the data provides an unparalleled resource for matching patients with the outcomes of demographically or diagnostically comparable patients. A web-based application was developed to query this subset of patient information against a given patient's demographics and risk factors. Analysis of the matched data yields outcome information which can then be used to guide management decisions and imaging software. Prognostic information is also estimated via the proportion of matched patients that progress to cancer. The US Preventative Services Task Force provides screening recommendations for cancers of the breast, colorectal tract, and lungs. There is wide variability in adherence of clinicians to these guidelines and others published by the Fleischner Society and various cancer organizations. Data mining the PLCO dataset for clinical decision support can optimize the use of limited healthcare resources, focusing screening on patients for whom the benefit to risk ratio is the greatest and most efficacious. A data driven, personalized approach to cancer screening maximizes the economic and clinical efficacy and enables early identification of patients in which the course of disease can be improved. Our dynamic decision support system utilizes a subset of the PLCO dataset as a reference model to determine imaging and testing appropriateness while offering prognostic information for various cancers. PMID:26385814

  15. SCINTILLATION SPECTROMETER

    DOEpatents

    Bell, P.R.; Francis, J.E.

    1960-06-21

    A portable scintillation spectrometer is described which is especially useful in radio-biological studies for determining the uptake and distribution of gamma -emitting substances in tissue. The spectrometer includes a collimator having a plurality of apertures that are hexagonal in cross section. Two crystals are provided: one is activated to respond to incident rays from the collimator; the other is not activated and shields the first from external radiation.

  16. Plastic scintillation dosimetry: Optimal selection of scintillating fibers and scintillators

    SciTech Connect

    Archambault, Louis; Arsenault, Jean; Gingras, Luc; Sam Beddar, A.; Roy, Rene; Beaulieu, Luc

    2005-07-15

    Scintillation dosimetry is a promising avenue for evaluating dose patterns delivered by intensity-modulated radiation therapy plans or for the small fields involved in stereotactic radiosurgery. However, the increase in signal has been the goal for many authors. In this paper, a comparison is made between plastic scintillating fibers and plastic scintillator. The collection of scintillation light was measured experimentally for four commercial models of scintillating fibers (BCF-12, BCF-60, SCSF-78, SCSF-3HF) and two models of plastic scintillators (BC-400, BC-408). The emission spectra of all six scintillators were obtained by using an optical spectrum analyzer and they were compared with theoretical behavior. For scintillation in the blue region, the signal intensity of a singly clad scintillating fiber (BCF-12) was 120% of that of the plastic scintillator (BC-400). For the multiclad fiber (SCSF-78), the signal reached 144% of that of the plastic scintillator. The intensity of the green scintillating fibers was lower than that of the plastic scintillator: 47% for the singly clad fiber (BCF-60) and 77% for the multiclad fiber (SCSF-3HF). The collected light was studied as a function of the scintillator length and radius for a cylindrical probe. We found that symmetric detectors with nearly the same spatial resolution in each direction (2 mm in diameter by 3 mm in length) could be made with a signal equivalent to those of the more commonly used asymmetric scintillators. With augmentation of the signal-to-noise ratio in consideration, this paper presents a series of comparisons that should provide insight into selection of a scintillator type and volume for development of a medical dosimeter.

  17. Screening for Usher Syndrome: A Hands-On Guide for School Nurses.

    ERIC Educational Resources Information Center

    Houghton, Joan; Coonts, Teresa; Jordan, Beth; Schafer, Jacqueline, Ed.

    This manual was written specifically to help school nurses conduct screenings for Usher syndrome, a genetic condition that involves deafness or hearing loss and the progressive loss of vision. It provides information on the step-by-step process of how to conduct a screening, the actual forms needed for a screening, and resources for referring…

  18. Large volume flow-through scintillating detector

    DOEpatents

    Gritzo, Russ E.; Fowler, Malcolm M.

    1995-01-01

    A large volume flow through radiation detector for use in large air flow situations such as incinerator stacks or building air systems comprises a plurality of flat plates made of a scintillating material arranged parallel to the air flow. Each scintillating plate has a light guide attached which transfers light generated inside the scintillating plate to an associated photomultiplier tube. The output of the photomultiplier tubes are connected to electronics which can record any radiation and provide an alarm if appropriate for the application.

  19. TAKING IT TO THE PEWS: A CBPR-GUIDED HIV AWARENESS AND SCREENING PROJECT WITH BLACK CHURCHES

    PubMed Central

    Berkley-Patton, Jannette; Bowe-Thompson, Carole; Bradley-Ewing, Andrea; Hawes, Starlyn; Moore, Erin; Williams, Eric; Martinez, David; Goggin, Kathy

    2014-01-01

    Utilizing a community-based participatory research (CBPR) approach is a potentially effective strategy for exploring the development, implementation, and evaluation of HIV interventions in African American churches. This CBPR-guided study describes a church-based HIV awareness and screening intervention (Taking It to the Pews [TIPS]) that fully involved African American church leaders in all phases of the research project. Findings from the implementation and evaluation phases indicated that church leaders delivered TIPS Tool Kit activities on an ongoing basis (about twice a month) over a 9-month period. TIPS church members were highly exposed to TIPS activities (e.g., 91% reported receiving HIV educational brochures, 84% heard a sermon about HIV). Most (87%) believed that the church should talk about HIV, and 77% believed that the church should offer HIV screening. These findings suggest that implementing an HIV intervention in Black church settings is achievable, particularly when a CBPR approach is used. PMID:20528130

  20. Recombinant Pseudorabies Virus (PRV) Expressing Firefly Luciferase Effectively Screened for CRISPR/Cas9 Single Guide RNAs and Antiviral Compounds.

    PubMed

    Tang, Yan-Dong; Liu, Ji-Ting; Fang, Qiong-Qiong; Wang, Tong-Yun; Sun, Ming-Xia; An, Tong-Qing; Tian, Zhi-Jun; Cai, Xue-Hui

    2016-04-01

    A Pseudorabies virus (PRV) variant has emerged in China since 2011 that is not protected by commercial vaccines, and has not been well studied. The PRV genome is large and difficult to manipulate, but it is feasible to use clustered, regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology. However, identification of single guide RNA (sgRNA) through screening is critical to the CRISPR/Cas9 system, and is traditionally time and labor intensive, and not suitable for rapid and high throughput screening of effective PRV sgRNAs. In this study, we developed a recombinant PRV strain expressing firefly luciferase and enhanced green fluorescent protein (EGFP) as a reporter virus for PRV-specific sgRNA screens and rapid evaluation of antiviral compounds. Luciferase activity was apparent as soon as 4 h after infection and was stably expressed through 10 passages. In a proof of the principle screen, we were able to identify several PRV specific sgRNAs and confirmed that they inhibited PRV replication using traditional methods. Using the reporter virus, we also identified PRV variants lacking US3, US2, and US9 gene function, and showed anti-PRV activity for chloroquine. Our results suggest that the reporter PRV strain will be a useful tool for basic virology studies, and for developing PRV control and prevention measures. PMID:27043610

  1. Recombinant Pseudorabies Virus (PRV) Expressing Firefly Luciferase Effectively Screened for CRISPR/Cas9 Single Guide RNAs and Antiviral Compounds

    PubMed Central

    Tang, Yan-Dong; Liu, Ji-Ting; Fang, Qiong-Qiong; Wang, Tong-Yun; Sun, Ming-Xia; An, Tong-Qing; Tian, Zhi-Jun; Cai, Xue-Hui

    2016-01-01

    A Pseudorabies virus (PRV) variant has emerged in China since 2011 that is not protected by commercial vaccines, and has not been well studied. The PRV genome is large and difficult to manipulate, but it is feasible to use clustered, regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology. However, identification of single guide RNA (sgRNA) through screening is critical to the CRISPR/Cas9 system, and is traditionally time and labor intensive, and not suitable for rapid and high throughput screening of effective PRV sgRNAs. In this study, we developed a recombinant PRV strain expressing firefly luciferase and enhanced green fluorescent protein (EGFP) as a reporter virus for PRV-specific sgRNA screens and rapid evaluation of antiviral compounds. Luciferase activity was apparent as soon as 4 h after infection and was stably expressed through 10 passages. In a proof of the principle screen, we were able to identify several PRV specific sgRNAs and confirmed that they inhibited PRV replication using traditional methods. Using the reporter virus, we also identified PRV variants lacking US3, US2, and US9 gene function, and showed anti-PRV activity for chloroquine. Our results suggest that the reporter PRV strain will be a useful tool for basic virology studies, and for developing PRV control and prevention measures. PMID:27043610

  2. Risk assessment to guide cervical screening strategies in a large Chinese population.

    PubMed

    Zhao, Fang-Hui; Hu, Shang-Ying; Zhang, Qian; Zhang, Xun; Pan, Qin-Jing; Zhang, Wen-Hua; Gage, Julia C; Wentzensen, Nicolas; Castle, Philip E; Qiao, You-Lin; Katki, Hormuzd A; Schiffman, Mark

    2016-06-01

    Three different cervical screening methods [cytology, human papillomavirus(HPV) testing and visual inspection with acetic acid(VIA)] are being considered in China for the national cervical screening program. Comparing risks of CIN3 and cervical cancer (CIN3+) for different results can inform test choice and management guidelines. We evaluated the immediate risk of CIN3+ for different screening results generated from individual and combined tests. We compared tests using a novel statistic designed for this purpose called Mean Risk Stratification (MRS), in a pooled analysis of 17 cross sectional population-based studies of 30,371 Chinese women screened with all 3 methods and diagnosed by colposcopically-directed biopsies. The 3 tests combined powerfully distinguished CIN3+ risk; triple-negative screening conferred a risk of 0.01%, while HPV-positive HSIL+ that was VIA-positive yielded a risk of 57.8%. Among the three screening tests, HPV status most strongly stratified CIN3+ risk. Among HPV-positive women, cytology was the more useful second test. In HPV-negative women, the immediate risks of CIN3+ ranged from 0.01% (negative cytology), 0.00% (ASC-US), 1.1% (LSIL), to 6.6 (HSIL+). In HPV-positive women, the CIN3+ risks were 0.9% (negative cytology), 3.6% (ASC-US), 6.3% (LSIL) and 38.5% (HSIL+). VIA results did not meaningful stratify CIN3+ risk among HPV-negative women with negative or ASC-US cytology; however, positive VIA substantially elevated CIN3+ risk for all other, more positive combinations of HPV and cytology compared with a negative VIA. Because all 3 screening tests had independent value in defining risk of CIN3+, different combinations can be optimized as pragmatic strategies in different resource settings. PMID:26800481

  3. NMR screening in fragment-based drug design: a practical guide.

    PubMed

    Kim, Hai-Young; Wyss, Daniel F

    2015-01-01

    Fragment-based drug design (FBDD) comprises both fragment-based screening (FBS) to find hits and elaboration of these hits to lead compounds. Typical fragment hits have lower molecular weight (<300-350 Da) and lower initial potency but higher ligand efficiency when compared to those from high-throughput screening. NMR spectroscopy has been widely used for FBDD since it identifies and localizes the binding site of weakly interacting hits on the target protein. Here we describe ligand-based NMR methods for hit identification from fragment libraries and for functional cross-validation of primary hits. PMID:25618347

  4. Scintillators and applications thereof

    DOEpatents

    Williams, Richard T.

    2014-07-15

    Scintillators of various constructions and methods of making and using the same are provided. In some embodiments, a scintillator comprises at least one radiation absorption region and at least one spatially discrete radiative exciton recombination region.

  5. Scintillators and applications thereof

    SciTech Connect

    Williams, Richard T.

    2015-09-01

    Scintillators of various constructions and methods of making and using the same are provided. In some embodiments, a scintillator comprises at least one radiation absorption region and at least one spatially discrete radiative exciton recombination region.

  6. Scintillator efficiency study with MeV x-rays

    NASA Astrophysics Data System (ADS)

    Baker, Stuart; Brown, Kristina; Curtis, Alden; Lutz, Stephen S.; Howe, Russell; Malone, Robert; Mitchell, Stephen; Danielson, Jeremy; Haines, Todd; Kwiatkowski, Kris

    2014-09-01

    We have investigated scintillator efficiency for MeV radiographic imaging. This paper discusses the modeled detection efficiency and measured brightness of a number of scintillator materials. An optical imaging camera records images of scintillator emission excited by a pulsed x-ray machine. The efficiency of various thicknesses of monolithic LYSO:Ce (cerium-doped lutetium yttrium orthosilicate) are being studied to understand brightness and resolution trade-offs compared with a range of micro-columnar CsI:Tl (thallium-doped cesium iodide) scintillator screens. The micro-columnar scintillator structure apparently provides an optical gain mechanism that results in brighter signals from thinner samples. The trade-offs for brightness versus resolution in monolithic scintillators is straightforward. For higher-energy x-rays, thicker materials generally produce brighter signal due to x-ray absorption and the optical emission properties of the material. However, as scintillator thickness is increased, detector blur begins to dominate imaging system resolution due to the volume image generated in the scintillator thickness and the depth of field of the imaging system. We employ a telecentric optical relay lens to image the scintillator onto a recording CCD camera. The telecentric lens helps provide sharp focus through thicker-volume emitting scintillators. Stray light from scintillator emission can also affect the image scene contrast. We have applied an optical light scatter model to the imaging system to minimize scatter sources and maximize scene contrasts.

  7. Walkthrough screening evaluation field guide. Natural phenomena hazards at Department of Energy facilities: Revision 2

    SciTech Connect

    Eder, S.J.; Eli, M.W.; Salmon, M.W.

    1993-11-01

    The US Department of Energy (DOE) has a large inventory of existing facilities. Many of these facilities were not designed and constructed to current natural phenomena hazard (NPH) criteria. The NPH events include earthquakes, extreme winds and tornadoes, and floods. DOE Order 5480.28 establishes policy and requirements for NPH mitigation for DOE facilities. DOE is conducting a multiyear project to develop evaluation guidelines for assessing the condition and determining the need for upgrades at DOE facilities. One element of the NPH evaluation guidelines` development involves the existing systems and components at DOE facilities. This effort is described in detail in a cited reference. In the interim period prior to availability of the final guidelines, DOE facilities are encouraged to implement an NPH walk through screening evaluation process by which systems and components that need attention can be rapidly identified. Guidelines for conducting the walk through screening evaluations are contained herein. The result of the NPH walk through screening evaluation should be a prioritized list of systems and components that need further action. Simple and inexpensive fixes for items identified in the walk through as marginal or inadequate should be implemented without further study. By implementing an NPH walk through screening evaluation, DOE facilities may realize significant reduction in risk from NPH in the short term.

  8. A practical guide to Quantative Interactotr Screening with Next Generation Sequencing

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Yeast two-hybrid screens are a powerful approach to identify protein-protein interactions; however, they are typically limited in the number of interactions identified, and lack quantitative values to ascribe confidence scores to the interactions that are obtained. We have developed a high-throughpu...

  9. Lead carbonate scintillator materials

    DOEpatents

    Derenzo, Stephen E.; Moses, William W.

    1991-01-01

    Improved radiation detectors containing lead carbonate or basic lead carbonate as the scintillator element are disclosed. Both of these scintillators have been found to provide a balance of good stopping power, high light yield and short decay constant that is superior to other known scintillator materials. The radiation detectors disclosed are favorably suited for use in general purpose detection and in medical uses.

  10. Scintillator materials for calorimetry

    SciTech Connect

    Weber, M.J.

    1994-09-01

    Requirements for fast, dense scintillator materials for calorimetry in high energy physics and approaches to satisfying these requirements are reviewed with respect to possible hosts and luminescent species. Special attention is given to cerium-activated crystals, core-valence luminescence, and glass scintillators. The present state of the art, limitations, and suggestions for possible new scintillator materials are presented.

  11. Scintillator manufacture at Fermilab

    SciTech Connect

    Mellott, K.; Bross, A.; Pla-Dalmau, A.

    1998-08-01

    A decade of research into plastic scintillation materials at Fermilab is reviewed. Early work with plastic optical fiber fabrication is revisited and recent experiments with large-scale commercial methods for production of bulk scintillator are discussed. Costs for various forms of scintillator are examined and new development goals including cost reduction methods and quality improvement techniques are suggested.

  12. Daily targeting of liver tumors: Screening patients with a mock treatment and using a combination of internal and external fiducials for image-guided respiratory-gated radiotherapy

    SciTech Connect

    Krishnan, Sunil; Briere, Tina Marie; Dong Lei; Murthy, Ravi; Ng, Chaan; Balter, Peter; Mohan, Radhe; Gillin, Michael T.; Beddar, A. Sam

    2007-12-15

    The feasibility and accuracy of using a mock treatment to screen suitable patients for respiratory-gated image-guided radiotherapy was investigated. Radio-opaque fiducials implanted adjacent to the liver tumor were used for online positioning to minimize the systematic error in patient positioning. The consistency in the degree of correlation between the external and internal fiducials was analyzed during a mock treatment. This technique could screen patients for gated therapy, reduce setup inaccuracy, and possibly individualize treatment margins.

  13. Scintillator reflective layer coextrusion

    SciTech Connect

    Yun, Jae-Chul; Para, Adam

    2001-01-01

    A polymeric scintillator has a reflective layer adhered to the exterior surface thereof. The reflective layer comprises a reflective pigment and an adhesive binder. The adhesive binder includes polymeric material from which the scintillator is formed. A method of forming the polymeric scintillator having a reflective layer adhered to the exterior surface thereof is also provided. The method includes the steps of (a) extruding an inner core member from a first amount of polymeric scintillator material, and (b) coextruding an outer reflective layer on the exterior surface of the inner core member. The outer reflective layer comprises a reflective pigment and a second amount of the polymeric scintillator material.

  14. Research into the usage of integrated jamming of IR weakening and smoke-screen resisting the IR imaging guided missiles

    NASA Astrophysics Data System (ADS)

    Wang, Long-tao; Jiang, Ning; Lv, Ming-shan

    2015-10-01

    With the emergence of the anti-ship missle with the capability of infrared imaging guidance, the traditional single jamming measures, because of the jamming mechanism and technical flaws or unsuitable use, greatly reduced the survival probability of the war-ship in the future naval battle. Intergrated jamming of IR weakening + smoke-screen Can not only make jamming to the search and tracking of IR imaging guidance system , but also has feasibility in conjunction, besides , which also make the best jamming effect. The research conclusion has important realistic meaning for raising the antimissile ability of surface ships. With the development of guidance technology, infrared guidance system has expanded by ir point-source homing guidance to infrared imaging guidance, Infrared imaging guidance has made breakthrough progress, Infrared imaging guidance system can use two-dimensional infrared image information of the target, achieve the precise tracking. Which has Higher guidance precision, better concealment, stronger anti-interference ability and could Target the key parts. The traditional single infrared smoke screen jamming or infrared decoy flare interference cannot be imposed effective interference. So, Research how to effectively fight against infrared imaging guided weapons threat measures and means, improving the surface ship antimissile ability is an urgent need to solve.

  15. Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei

    PubMed Central

    Creek, Darren J.; Nijagal, Brunda; Kim, Dong-Hyun; Rojas, Federico; Matthews, Keith R.

    2013-01-01

    In vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to make them more biologically relevant or to optimize growth is traditionally a laborious task. Emerging metabolomic technology enables the rapid evaluation of intra- and extracellular metabolites and can be applied to the rational development of cell culture media. In this study, untargeted semiquantitative and targeted quantitative metabolomic analyses of fresh and spent media revealed the major nutritional requirements for the growth of bloodstream form Trypanosoma brucei. The standard culture medium (HMI11) contained unnecessarily high concentrations of 32 nutrients that were subsequently removed to make the concentrations more closely resemble those normally found in blood. Our new medium, Creek's minimal medium (CMM), supports in vitro growth equivalent to that in HMI11 and causes no significant perturbation of metabolite levels for 94% of the detected metabolome (<3-fold change; α = 0.05). Importantly, improved sensitivity was observed for drug activity studies in whole-cell phenotypic screenings and in the metabolomic mode of action assays. Four-hundred-fold 50% inhibitory concentration decreases were observed for pentamidine and methotrexate, suggesting inhibition of activity by nutrients present in HMI11. CMM is suitable for routine cell culture and offers important advantages for metabolomic studies and drug activity screening. PMID:23571546

  16. A lens-coupled scintillation counter in cryogenic environment

    NASA Astrophysics Data System (ADS)

    Stoykov, A.; Scheuermann, R.; Amato, A.; Bartkowiak, M.; Konter, J. A.; Rodriguez, J.; Sedlak, K.

    2011-02-01

    In this work we present an elegant solution for a scintillation counter to be integrated into a cryogenic system. Its distinguishing feature is the absence of a continuous light guide coupling the scintillation and the photodetector parts, operating at cryogenic and room temperatures respectively. The prototype detector consists of a plastic scintillator with glued-in wavelength-shifting fiber located inside a cryostat, a Geiger-mode Avalanche Photodiode (G-APD) outside the cryostat, and a lens system guiding the scintillation light re-emitted by the fiber to the G-APD through optical windows in the cryostat shields. With a 0.8 mm diameter multiclad fiber and a 1 mm active area G-APD the coupling efficiency of the ``lens light guide" is about 50 %. A reliable performance of the detector down to 3 K is demonstrated.

  17. Multi-PSPMT scintillation camera

    SciTech Connect

    Pani, R.; Pellegrini, R.; Trotta, G.; Scopinaro, F.; Soluri, A.; Vincentis, G. de; Scafe, R.; Pergola, A.

    1999-06-01

    Gamma ray imaging is usually accomplished by the use of a relatively large scintillating crystal coupled to either a number of photomultipliers (PMTs) (Anger Camera) or to a single large Position Sensitive PMT (PSPMT). Recently the development of new diagnostic techniques, such as scintimammography and radio-guided surgery, have highlighted a number of significant limitations of the Anger camera in such imaging procedures. In this paper a dedicated gamma camera is proposed for clinical applications with the aim of improving image quality by utilizing detectors with an appropriate size and shape for the part of the body under examination. This novel scintillation camera is based upon an array of PSPMTs (Hamamatsu R5900-C8). The basic concept of this camera is identical to the Anger Camera with the exception of the substitution of PSPMTs for the PMTs. In this configuration it is possible to use the high resolution of the PSPMTs and still correctly position events lying between PSPMTs. In this work the test configuration is a 2 by 2 array of PSPMTs. Some advantages of this camera are: spatial resolution less than 2 mm FWHM, good linearity, thickness less than 3 cm, light weight, lower cost than equivalent area PSPMT, large detection area when coupled to scintillating arrays, small dead boundary zone (< 3 mm) and flexibility in the shape of the camera.

  18. Recent development in organic scintillators

    NASA Technical Reports Server (NTRS)

    Horrocks, D. L.; Wirth, H. O.

    1969-01-01

    Discussion on recent developments of organic scintillators includes studies of organic compounds that form glass-like masses which scintillate and are stable at room temperature, correlations between molecular structure of organic scintillators and self-quenching, recently developed fast scintillators, and applications of liquid-scintillation counters.

  19. Shifting scintillator neutron detector

    SciTech Connect

    Clonts, Lloyd G; Cooper, Ronald G; Crow, Jr., Morris Lowell; Hannah, Bruce W; Hodges, Jason P; Richards, John D; Riedel, Richard A

    2014-03-04

    Provided are sensors and methods for detecting thermal neutrons. Provided is an apparatus having a scintillator for absorbing a neutron, the scintillator having a back side for discharging a scintillation light of a first wavelength in response to the absorbed neutron, an array of wavelength-shifting fibers proximate to the back side of the scintillator for shifting the scintillation light of the first wavelength to light of a second wavelength, the wavelength-shifting fibers being disposed in a two-dimensional pattern and defining a plurality of scattering plane pixels where the wavelength-shifting fibers overlap, a plurality of photomultiplier tubes, in coded optical communication with the wavelength-shifting fibers, for converting the light of the second wavelength to an electronic signal, and a processor for processing the electronic signal to identify one of the plurality of scattering plane pixels as indicative of a position within the scintillator where the neutron was absorbed.

  20. Scintillator manufacture at Fermilab

    SciTech Connect

    Mellott, K.; Bross, A.; Pla-Dalmau, A.

    1998-11-01

    A decade of research into plastic scintillation materials at Fermilab is reviewed. Early work with plastic optical fiber fabrication is revisited and recent experiments with large-scale commercial methods for production of bulk scintillator are discussed. Costs for various forms of scintillator are examined and new development goals including cost reduction methods and quality improvement techniques are suggested. {copyright} {ital 1998 American Institute of Physics.}

  1. Lead carbonate scintillator materials

    DOEpatents

    Derenzo, S.E.; Moses, W.W.

    1991-05-14

    Improved radiation detectors containing lead carbonate or basic lead carbonate as the scintillator element are disclosed. Both of these scintillators have been found to provide a balance of good stopping power, high light yield and short decay constant that is superior to other known scintillator materials. The radiation detectors disclosed are favorably suited for use in general purpose detection and in medical uses. 3 figures.

  2. Extruded plastic scintillation detectors

    SciTech Connect

    Anna Pla-Dalmau, Alan D. Bross and Kerry L. Mellott

    1999-04-16

    As a way to lower the cost of plastic scintillation detectors, commercially available polystyrene pellets have been used in the production of scintillating materials that can be extruded into different profiles. The selection of the raw materials is discussed. Two techniques to add wavelength shifting dopants to polystyrene pellets and to extrude plastic scintillating strips are described. Data on light yield and transmittance measurements are presented.

  3. Study of equatorial scintillations

    NASA Technical Reports Server (NTRS)

    Pomalaza, J.; Woodman, R.; Tisnado, G.; Nakasone, E.

    1972-01-01

    Observations of the amplitude scintillations produced by the F-region in equatorial areas are presented. The equipment used for conducting the observations is described. The use of transmissions from the ATS-1, ATS-3, and ATS-5 for obtaining data is described. The two principal subjects discussed are: (1) correlation between satellite and incoherent radar observations of scintillations and (2) simultaneous observations of scintillations at 136 MHz and 1550 MHz.

  4. The COMP-Ident Find-Screen Planning Package. A Descriptive Manual And Organizational Guide for Planning and Conducting Child Find/Screen Efforts in Rural Areas.

    ERIC Educational Resources Information Center

    Laub, Karen W.; And Others

    In order to comply with Public Law 94-142, Education for All Handicapped Children Act, procedures for planning and conducting screening (identification) and assessment of preschool handicapped children in rural areas were developed. Screening was accomplished by public awareness campaigns, health screening, or school census analysis. In the HICOMP…

  5. FEDS user`s guide: Facility energy screening. Release 2.10

    SciTech Connect

    Dirks, J.A.

    1995-01-01

    The Facility Energy Decision Screening (FEDS) Model is under development at Pacific Northwest Laboratory (PNL) for the US DOE Federal Energy Management Program (DOE-FEMP) and the US Army Construction Engineering REsearch Laboratory (USA-CERL). FEDS is a multi-level energy analysis software system designed to provide a comprehensive approach to fuel-neutral, technology-independent, integrated (energy) resource planning and acquisition. The FEDS system includes Level-1, which is a top-down, first-pass energy systems analysis and energy resource acquisition decision software model for buildings and facilities, and the Level-2 software model, which allows specific engineering inputs and provides detailed output. The basic intent of the model is to provide an installation with the information necessary to determine the minimum life-cycle cost (LCC) configuration of the installation`s energy generation and consumption infrastructure. The model has no fuel or technology bias; it simply selects the technologies that will provide an equivalent or superior level of service (e.g., heating, cooling, illumination) at the minimum LCC.

  6. Expression of translationally controlled tumor protein (TCTP) gene of Dirofilaria immitis guided by transcriptomic screening.

    PubMed

    Fu, Yan; Lan, Jingchao; Wu, Xuhang; Yang, Deying; Zhang, Zhihe; Nie, Huaming; Hou, Rong; Zhang, Runhui; Zheng, Wanpeng; Xie, Yue; Yan, Ning; Yang, Zhi; Wang, Chengdong; Luo, Li; Liu, Li; Gu, Xiaobin; Wang, Shuxian; Peng, Xuerong; Yang, Guangyou

    2014-02-01

    Dirofilaria immitis (heartworm) infections affect domestic dogs, cats, and various wild mammals with increasing incidence in temperate and tropical areas. More sensitive antibody detection methodologies are required to diagnose asymptomatic dirofilariasis with low worm burdens. Applying current transcriptomic technologies would be useful to discover potential diagnostic markers for D. immitis infection. A filarial homologue of the mammalian translationally controlled tumor protein (TCTP) was initially identified by screening the assembled transcriptome of D. immitis (DiTCTP). A BLAST analysis suggested that the DiTCTP gene shared the highest similarity with TCTP from Loa loa at protein level (97%). A histidine-tagged recombinant DiTCTP protein (rDiTCTP) of 40 kDa expressed in Escherichia coli BL21 (DE3) showed immunoreactivity with serum from a dog experimentally infected with heartworms. Localization studies illustrated the ubiquitous presence of rDiTCTP protein in the lateral hypodermal chords, dorsal hypodermal chord, muscle, intestine, and uterus in female adult worms. Further studies on D. immitis-derived TCTP are warranted to assess whether this filarial protein could be used for a diagnostic purpose. PMID:24623877

  7. Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway.

    PubMed

    Li, Gang; Diogo, Dorothée; Wu, Di; Spoonamore, Jim; Dancik, Vlado; Franke, Lude; Kurreeman, Fina; Rossin, Elizabeth J; Duclos, Grant; Hartland, Cathy; Zhou, Xuezhong; Li, Kejie; Liu, Jun; De Jager, Philip L; Siminovitch, Katherine A; Zhernakova, Alexandra; Raychaudhuri, Soumya; Bowes, John; Eyre, Steve; Padyukov, Leonid; Gregersen, Peter K; Worthington, Jane; Gupta, Namrata; Clemons, Paul A; Stahl, Eli; Tolliday, Nicola; Plenge, Robert M

    2013-05-01

    Although genetic and non-genetic studies in mouse and human implicate the CD40 pathway in rheumatoid arthritis (RA), there are no approved drugs that inhibit CD40 signaling for clinical care in RA or any other disease. Here, we sought to understand the biological consequences of a CD40 risk variant in RA discovered by a previous genome-wide association study (GWAS) and to perform a high-throughput drug screen for modulators of CD40 signaling based on human genetic findings. First, we fine-map the CD40 risk locus in 7,222 seropositive RA patients and 15,870 controls, together with deep sequencing of CD40 coding exons in 500 RA cases and 650 controls, to identify a single SNP that explains the entire signal of association (rs4810485, P = 1.4×10(-9)). Second, we demonstrate that subjects homozygous for the RA risk allele have ∼33% more CD40 on the surface of primary human CD19+ B lymphocytes than subjects homozygous for the non-risk allele (P = 10(-9)), a finding corroborated by expression quantitative trait loci (eQTL) analysis in peripheral blood mononuclear cells from 1,469 healthy control individuals. Third, we use retroviral shRNA infection to perturb the amount of CD40 on the surface of a human B lymphocyte cell line (BL2) and observe a direct correlation between amount of CD40 protein and phosphorylation of RelA (p65), a subunit of the NF-κB transcription factor. Finally, we develop a high-throughput NF-κB luciferase reporter assay in BL2 cells activated with trimerized CD40 ligand (tCD40L) and conduct an HTS of 1,982 chemical compounds and FDA-approved drugs. After a series of counter-screens and testing in primary human CD19+ B cells, we identify 2 novel chemical inhibitors not previously implicated in inflammation or CD40-mediated NF-κB signaling. Our study demonstrates proof-of-concept that human genetics can be used to guide the development of phenotype-based, high-throughput small-molecule screens to identify potential novel therapies in

  8. Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway

    PubMed Central

    Li, Gang; Diogo, Dorothée; Wu, Di; Spoonamore, Jim; Dancik, Vlado; Franke, Lude; Kurreeman, Fina; Rossin, Elizabeth J.; Duclos, Grant; Hartland, Cathy; Zhou, Xuezhong; Li, Kejie; Liu, Jun; De Jager, Philip L.; Siminovitch, Katherine A.; Zhernakova, Alexandra; Raychaudhuri, Soumya; Bowes, John; Eyre, Steve; Padyukov, Leonid; Gregersen, Peter K.; Worthington, Jane; Gupta, Namrata; Clemons, Paul A.; Stahl, Eli; Tolliday, Nicola; Plenge, Robert M.

    2013-01-01

    Although genetic and non-genetic studies in mouse and human implicate the CD40 pathway in rheumatoid arthritis (RA), there are no approved drugs that inhibit CD40 signaling for clinical care in RA or any other disease. Here, we sought to understand the biological consequences of a CD40 risk variant in RA discovered by a previous genome-wide association study (GWAS) and to perform a high-throughput drug screen for modulators of CD40 signaling based on human genetic findings. First, we fine-map the CD40 risk locus in 7,222 seropositive RA patients and 15,870 controls, together with deep sequencing of CD40 coding exons in 500 RA cases and 650 controls, to identify a single SNP that explains the entire signal of association (rs4810485, P = 1.4×10−9). Second, we demonstrate that subjects homozygous for the RA risk allele have ∼33% more CD40 on the surface of primary human CD19+ B lymphocytes than subjects homozygous for the non-risk allele (P = 10−9), a finding corroborated by expression quantitative trait loci (eQTL) analysis in peripheral blood mononuclear cells from 1,469 healthy control individuals. Third, we use retroviral shRNA infection to perturb the amount of CD40 on the surface of a human B lymphocyte cell line (BL2) and observe a direct correlation between amount of CD40 protein and phosphorylation of RelA (p65), a subunit of the NF-κB transcription factor. Finally, we develop a high-throughput NF-κB luciferase reporter assay in BL2 cells activated with trimerized CD40 ligand (tCD40L) and conduct an HTS of 1,982 chemical compounds and FDA–approved drugs. After a series of counter-screens and testing in primary human CD19+ B cells, we identify 2 novel chemical inhibitors not previously implicated in inflammation or CD40-mediated NF-κB signaling. Our study demonstrates proof-of-concept that human genetics can be used to guide the development of phenotype-based, high-throughput small-molecule screens to identify potential novel therapies in

  9. A study guided by the Health Belief Model of the predictors of breast cancer screening of women ages 40 and older.

    PubMed Central

    Fulton, J P; Buechner, J S; Scott, H D; DeBuono, B A; Feldman, J P; Smith, R A; Kovenock, D

    1991-01-01

    In late 1987, a total of 852 Rhode Island women ages 40 and older were interviewed by telephone (78 percent response rate) to measure their use of breast cancer screening and to investigate potential predictors of use. Predictors included the women's socioeconomic status, use of medical care, a provider's reported recommendations for screening, and the women's health beliefs about breast cancer and mammography. The Health Belief Model guided the construction of the interview questions and data analysis. Logistic regression was used to identify leading independent predictors of breast cancer screening according to contemporary recommendations: reporting that a medical provider had ever recommended a screening mammogram (odds ratio [OR] = 18.77), having received gynecological care in the previous year (OR = 4.92), having a regular source of gynecological care (OR = 2.63), having ever had a diagnostic mammogram (OR = 2.32), and perceiving mammography as safe enough to have annually (OR = 1.93). The findings suggest that programs intended to increase the use of breast cancer screening should include "inreach" and "outreach" elements; inreach to patients with established patient-provider relationships, by assuring that physicians recommend screening to all eligible patients, and outreach to all eligible women, by helping them overcome barriers to effective primary care, and by promoting mammography, emphasizing its effectiveness and safety. The findings also suggest that socioeconomically disadvantaged women, who are less likely to be screened than other women, should become special targets of inreach and outreach interventions. PMID:1908592

  10. Toxicology screen

    MedlinePlus

    Barbiturates - screen; Benzodiazepines - screen; Amphetamines - screen; Analgesics - screen; Antidepressants - screen; Narcotics - screen; Phenothiazines - screen; Drug abuse screen; Blood alcohol test

  11. Thin film scintillators

    NASA Astrophysics Data System (ADS)

    McDonald, Warren; McKinney, George; Tzolov, Marian

    2015-03-01

    Scintillating materials convert energy flux (particles or electromagnetic waves) into light with spectral characteristic matching a subsequent light detector. Commercial scintillators such as yttrium aluminum garnet (YAG) and yttrium aluminum perovskite (YAP) are commonly used. These are inefficient at lower energies due to the conductive coating present on their top surface, which is needed to avoid charging. We hypothesize that nano-structured thin film scintillators will outperform the commercial scintillators at low electron energies. We have developed alternative thin film scintillators, zinc tungstate and zinc oxide, which show promise for higher sensitivity to lower energy electrons since they are inherently conductive. Zinc tungstate films exhibit photoluminescence quantum efficiency of 74%. Cathodoluminescence spectroscopy was applied in transmission and reflection geometries. The comparison between the thin films and the YAG and YAP commercial scintillators shows much higher light output from the zinc tungstate and zinc oxide at electron energies less than 5 keV. Our films were integrated in a backscattered electron detector. This detector delivers better images than an identical detector with commercial YAG scintillator at low electron energies. Dr. Nicholas Barbi from PulseTor LLC, Dr. Anura Goonewardene, NSF Grants: #0806660, #1058829, #0923047.

  12. Alpha counting and spectrometry using liquid scintillation methods

    SciTech Connect

    McDowell, W J

    1986-01-01

    The material in this report is intended to be a practical introduction and guide to the use of liquid scintillation for alpha counting and spectrometry. Other works devoted to the development of the theory of liquid scintillation exist and a minimum of such material is repeated here. Much remains to be learned and many improvements remain to be made in the use of liquid scintillation for alpha counting and spectrometry. It is hoped that this modest work will encourage others to continue development in the field.

  13. User's Guide to the Water-Analysis Screening Tool (WAST): A Tool for Assessing Available Water Resources in Relation to Aquatic-Resource Uses

    USGS Publications Warehouse

    Stuckey, Marla H.; Kiesler, James L.

    2008-01-01

    A water-analysis screening tool (WAST) was developed by the U.S. Geological Survey, in partnership with the Pennsylvania Department of Environmental Protection, to provide an initial screening of areas in the state where potential problems may exist related to the availability of water resources to meet current and future water-use demands. The tool compares water-use information to an initial screening criteria of the 7-day, 10-year low-flow statistic (7Q10) resulting in a screening indicator for influences of net withdrawals (withdrawals minus discharges) on aquatic-resource uses. This report is intended to serve as a guide for using the screening tool. The WAST can display general basin characteristics, water-use information, and screening-indicator information for over 10,000 watersheds in the state. The tool includes 12 primary functions that allow the user to display watershed information, edit water-use and water-supply information, observe effects downstream from edited water-use information, reset edited values to baseline, load new water-use information, save and retrieve scenarios, and save output as a Microsoft Excel spreadsheet.

  14. Development of the Risk Appraisal Measure (RAM): A Brief Screen to Identify Risk Areas and Guide Interventions for Dementia Caregivers

    PubMed Central

    Czaja, Sara J.; Gitlin, Laura N.; Schulz, Richard; Zhang, Song; Burgio, Louis D.; Stevens, Alan B.; Nichols, Linda O.; Gallagher-Thompson, Dolores

    2009-01-01

    Objectives Family caregivers play a significant role in the health care of patients with dementia yet their needs and health status are often overlooked. This study developed and validated a brief screening measure for use in research, health care and community settings to systematically assess well-being and identify needed areas of support for caregivers of patients with dementia. Design This study used data from Resources for Enhancing Alzheimer’s Caregiver Health (REACH II), a multi-site, randomized, clinical trial of a behavioral intervention designed to improve the quality of life of caregivers in multiple domains. PARTICIPANTS: Two-hundred and twelve Hispanic, 211 Black/African American and 219 White family community dwelling dementia caregiver dyads providing in-home care to patients with dementia. Measurement Based on conceptual and psychometric analyses, a 16-item measure was developed that taps six domains linked to caregiver risk and amenable to intervention: depression, burden, self-care and health behaviors, social support, safety, and patient problem behaviors. The reliability and validity of the instrument was evaluated with 642 dementia caregiver dyads from the REACH II program. Results The measure was found to have acceptable internal consistency for a multi-dimensional scale and similar measurement properties for each of the racial/ethnic groups. Concurrent validity was also demonstrated for the measure. Conclusion The REACH Risk Appraisal Measure (RAM) developed in this study shows promise as an assessment tool that can be used in research, clinical and community settings to guide, prioritize, and target needed areas of support for caregivers of patients with dementia. PMID:19453305

  15. Bioassay-guided discovery of antibacterial agents: in vitro screening of Peperomia vulcanica, Peperomia fernandopoioana and Scleria striatinux

    PubMed Central

    2012-01-01

    Background The global burden of bacterial infections is high and has been further aggravated by increasing resistance to antibiotics. In the search for novel antibacterials, three medicinal plants: Peperomia vulcanica, Peperomia fernandopoioana (Piperaceae) and Scleria striatinux (Cyperaceae), were investigated for antibacterial activity and toxicity. Methods Crude extracts of these plants were tested by the disc diffusion method against six bacterial test organisms followed by bio-assay guided fractionation, isolation and testing of pure compounds. The minimum inhibitory (MIC) and minimum bactericidal (MBC) concentrations were measured by the microdilution method. The acute toxicity of the active extracts and cytotoxicity of the active compound were performed in mice and mammalian cells, respectively. Results The diameter of the zones of inhibition (DZI) of the extracts ranged from 7–13 mm on Escherichia coli and Staphylococcus aureus of which the methylene chloride:methanol [1:1] extract of Scleria striatinux recorded the highest activity (DZI = 13 mm). Twenty-nine pure compounds were screened and one, Okundoperoxide, isolated from S. striatinux, recorded a DZI ranging from 10–19 mm on S. aureus. The MICs and MBCs indicated that the Peperomias had broad-spectrum bacteriostatic activity. Toxicity tests showed that Okundoperoxide may have a low risk of toxicity with an LC50 of 46.88 μg/mL. Conclusions The antibacterial activity of these plants supports their use in traditional medicine. The pure compound, Okundoperoxide, may yield new antibacterial lead compounds following medicinal chemistry exploration. PMID:22549052

  16. Time resolution of a scintillating fiber detector

    NASA Astrophysics Data System (ADS)

    Horikawa, S.; Toeda, T.; Daito, I.; Doushita, N.; Hasegawa, T.; Horikawa, N.; Iwata, T.; Kibe, Y.; Matsuda, T.; Miyachi, Y.; Noboriguchi, K.; Takabayashi, N.; Tohyama, T.; Wakai, A.

    1999-07-01

    The performance of scintillating fiber detectors with 2 m long light guides was investigated for COMPASS experiment, using a 450 MeV/ c electron beam.Prototypes consisting of 0.5 mm diameter fibers (Kuraray SCSF-38 single-cladding) with the position-sensitive photomultipliers H6568 (Hamamatsu) were constructed for the test. The time resolution of σ˜430 ps was obtained with about 10 photoelectrons for the prototype of 10-layers structure.

  17. Ionospheric Scintillation Explorer (ISX)

    NASA Astrophysics Data System (ADS)

    Iuliano, J.; Bahcivan, H.

    2015-12-01

    NSF has recently selected Ionospheric Scintillation Explorer (ISX), a 3U Cubesat mission to explore the three-dimensional structure of scintillation-scale ionospheric irregularities associated with Equatorial Spread F (ESF). ISX is a collaborative effort between SRI International and Cal Poly. This project addresses the science question: To what distance along a flux tube does an irregularity of certain transverse-scale extend? It has been difficult to measure the magnetic field-alignment of scintillation-scale turbulent structures because of the difficulty of sampling a flux tube at multiple locations within a short time. This measurement is now possible due to the worldwide transition to DTV, which presents unique signals of opportunity for remote sensing of ionospheric irregularities from numerous vantage points. DTV spectra, in various formats, contain phase-stable, narrowband pilot carrier components that are transmitted simultaneously. A 4-channel radar receiver will simultaneously record up to 4 spatially separated transmissions from the ground. Correlations of amplitude and phase scintillation patterns corresponding to multiple points on the same flux tube will be a measure of the spatial extent of the structures along the magnetic field. A subset of geometries where two or more transmitters are aligned with the orbital path will be used to infer the temporal development of the structures. ISX has the following broad impact. Scintillation of space-based radio signals is a space weather problem that is intensively studied. ISX is a step toward a CubeSat constellation to monitor worldwide TEC variations and radio wave distortions on thousands of ionospheric paths. Furthermore, the rapid sampling along spacecraft orbits provides a unique dataset to deterministically reconstruct ionospheric irregularities at scintillation-scale resolution using diffraction radio tomography, a technique that enables prediction of scintillations at other radio frequencies, and

  18. Scintillator Measurements for SNO+

    NASA Astrophysics Data System (ADS)

    Kaptanoglu, Tanner; SNO+ Collaboration

    2016-03-01

    SNO+ is a neutrino detector located 2km underground in the SNOLAB facility with the primary goal of searching for neutrinoless double beta decay. The detector will be filled with a liquid scintillator target primarily composed of linear alkyl benzene (LAB). As charged particles travel through the detector the LAB produces scintillation light which is detected by almost ten thousand PMTs. The LAB is loaded with Te130, an isotope known to undergo double beta decay. Additionally, the LAB is mixed with an additional fluor and wavelength shifter to improve the light output and shift the light to a wavelength regime in which the PMTs are maximally efficient. The precise scintillator optics drastically affect the ultimate sensitivity of SNO+. I will present work being done to measure the optical properties of the SNO+ scintillator cocktail. The measured properties are used as input to a scintillation model that allows us to extrapolate to the SNO+ scale and ultimately predict the sensitivity of the experiment. Additionally, I will present measurements done to characterize the R5912 PMT, a candidate PMT for the second phase of SNO+ that provides better light collection, improved charge resolution, and a narrower spread in timing.

  19. Uterine Fibroids: Correlation of T2 Signal Intensity with Semiquantitative Perfusion MR Parameters in Patients Screened for MR-guided High-Intensity Focused Ultrasound Ablation.

    PubMed

    Kim, Young-Sun; Lee, Jeong-Won; Choi, Chel Hun; Kim, Byoung-Gie; Bae, Duk-Soo; Rhim, Hyunchul; Lim, Hyo Keun

    2016-03-01

    Purpose To evaluate the relationships between T2 signal intensity and semiquantitative perfusion magnetic resonance (MR) parameters of uterine fibroids in patients who were screened for MR-guided high-intensity focused ultrasound (HIFU) ablation. Materials and Methods Institutional review board approval was granted, and informed consents were waived. One hundred seventy most symptom-relevant, nondegenerated uterine fibroids (mean diameter, 7.3 cm; range, 3.0-17.2 cm) in 170 women (mean age, 43.5 years; range, 24-56 years) undergoing screening MR examinations for MR-guided HIFU ablation from October 2009 to April 2014 were retrospectively analyzed. Fibroid signal intensity was assessed as the ratio of the fibroid T2 signal intensity to that of skeletal muscle. Parameters of semiquantitative perfusion MR imaging obtained during screening MR examination (peak enhancement, percentage of relative peak enhancement, time to peak [in seconds], wash-in rate [per seconds], and washout rate [per seconds]) were investigated to assess their relationships with T2 signal ratio by using multiple linear regression analysis. Correlations between T2 signal intensity and independently significant perfusion parameters were then evaluated according to fibroid type by using Spearman correlation test. Results Multiple linear regression analysis revealed that relative peak enhancement showed an independently significant correlation with T2 signal ratio (Β = 0.004, P < .001). Submucosal intracavitary (n = 20, ρ = 0.275, P = .240) and type III (n = 18, ρ = 0.082, P = .748) fibroids failed to show significant correlations between perfusion and T2 signal intensity, while significant correlations were found for all other fibroid types (ρ = 0.411-0.629, P < .05). Conclusion In possible candidates for MR-guided HIFU ablation, the T2 signal intensity of nondegenerated uterine fibroids showed an independently significant positive correlation with relative peak enhancement in most cases, except

  20. Re-exploration of the Codon Context Effect on Amber Codon-Guided Incorporation of Noncanonical Amino Acids in Escherichia coli by the Blue-White Screening Assay.

    PubMed

    Xu, Huan; Wang, Yan; Lu, Jiaqi; Zhang, Bo; Zhang, Ziwei; Si, Longlong; Wu, Ling; Yao, Tianzhuo; Zhang, Chuanling; Xiao, Sulong; Zhang, Lihe; Xia, Qing; Zhou, Demin

    2016-07-01

    The effect of codon context on amber codon-guided incorporation of noncanonical amino acids (NAAs) has been previously examined by antibiotic selection. Here, we re-explored this effect by screening a library in which three nucleotides upstream and downstream of the amber codon were randomised, and inserted within the lacZ-α gene. Thousands of clones were obtained and distinguished by the depth of blue colour upon exposure to X-gal. Large-scale sequencing revealed remarkable preferences in nucleotides downstream of the amber codon, and moderate preferences for upstream nucleotides. Nucleotide preference was quantified by a dual-luciferase assay, which verified that the optimum context for NAA incorporation, AATTAGACT, was applicable to different proteins. Our work provides a general guide for engineering amber codons into genes of interest in bacteria. PMID:27028123

  1. Integration of Microfractionation, qNMR and Zebrafish Screening for the In Vivo Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products

    PubMed Central

    Maes, Jan; Siverio-Mota, Dany; Marcourt, Laurence; Munck, Sebastian; Kamuhabwa, Appolinary R.; Moshi, Mainen J.; Esguerra, Camila V.; de Witte, Peter A. M.; Crawford, Alexander D.; Wolfender, Jean-Luc

    2013-01-01

    Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovery. Several challenges nevertheless persist with respect to NP discovery, including the time and effort required for bioassay-guided isolation of bioactive NPs, and the limited biomedical relevance to date of in vitro bioassays used in this context. With regard to bioassays, zebrafish have recently emerged as an effective model system for chemical biology, allowing in vivo high-content screens that are compatible with microgram amounts of compound. For the deconvolution of the complex extracts into their individual constituents, recent progress has been achieved on several fronts as analytical techniques now enable the rapid microfractionation of extracts, and microflow NMR methods have developed to the point of allowing the identification of microgram amounts of NPs. Here we combine advanced analytical methods with high-content screening in zebrafish to create an integrated platform for microgram-scale, in vivo NP discovery. We use this platform for the bioassay-guided fractionation of an East African medicinal plant, Rhynchosia viscosa, resulting in the identification of both known and novel isoflavone derivatives with anti-angiogenic and anti-inflammatory activity. Quantitative microflow NMR is used both to determine the structure of bioactive compounds and to quantify them for direct dose-response experiments at the microgram scale. The key advantages of this approach are (1) the microgram scale at which both biological and analytical experiments can be performed, (2) the speed and the rationality of the bioassay-guided fractionation – generic for NP extracts of diverse origin – that requires only limited sample-specific optimization and (3) the use of microflow NMR for quantification, enabling the identification and dose-response experiments with only tens of micrograms of each compound. This study demonstrates that a complete in vivo bioassay-guided

  2. Scintillator plate calorimetry

    SciTech Connect

    Price, L.E.

    1990-01-01

    Calorimetry using scintillator plates or tiles alternated with sheets of (usually heavy) passive absorber has been proven over multiple generations of collider detectors. Recent detectors including UA1, CDF, and ZEUS have shown good results from such calorimeters. The advantages offered by scintillator calorimetry for the SSC environment, in particular, are speed (<10 nsec), excellent energy resolution, low noise, and ease of achieving compensation and hence linearity. On the negative side of the ledger can be placed the historical sensitivity of plastic scintillators to radiation damage, the possibility of nonuniform response because of light attenuation, and the presence of cracks for light collection via wavelength shifting plastic (traditionally in sheet form). This approach to calorimetry is being investigated for SSC use by a collaboration of Ames Laboratory/Iowa State University, Argonne National Laboratory, Bicron Corporation, Florida State University, Louisiana State University, University of Mississippi, Oak Ridge National Laboratory, Virginia Polytechnic Institute and State University, Westinghouse Electric Corporation, and University of Wisconsin.

  3. Monte Carlo simulation of a novel water-equivalent electronic portal imaging device using plastic scintillating fibers

    SciTech Connect

    Teymurazyan, A.; Pang, G.

    2012-03-15

    Purpose: Most electronic portal imaging devices (EPIDs) developed so far use a thin Cu plate/phosphor screen to convert x-ray energies into light photons, while maintaining a high spatial resolution. This results in a low x-ray absorption and thus a low quantum efficiency (QE) of approximately 2-4% for megavoltage (MV) x-rays. A significant increase of QE is desirable for applications such as MV cone-beam computed tomography (MV-CBCT). Furthermore, the Cu plate/phosphor screen contains high atomic number (high-Z) materials, resulting in an undesirable over-response to low energy x-rays (due to photoelectric effect) as well as high energy x-rays (due to pair production) when used for dosimetric verification. Our goal is to develop a new MV x-ray detector that has a high QE and uses low-Z materials to overcome the obstacles faced by current MV x-ray imaging technologies. Methods: A new high QE and low-Z EPID is proposed. It consists of a matrix of plastic scintillating fibers embedded in a water-equivalent medium and coupled to an optically sensitive 2D active matrix flat panel imager (AMFPI) for image readout. It differs from the previous approach that uses segmented crystalline scintillators made of higher density and higher atomic number materials to detect MV x-rays. The plastic scintillating fibers are focused toward the x-ray source to avoid image blurring due to oblique incidence of off-axis x-rays. When MV x-rays interact with the scintillating fibers in the detector, scintillation light will be produced. The light photons produced in a fiber core and emitted within the acceptance angle of the fiber will be guided toward the AMFPI by total internal reflection. A Monte Carlo simulation has been used to investigate imaging and dosimetric characteristics of the proposed detector under irradiation of MV x-rays. Results: Properties, such as detection efficiency, modulation transfer function, detective quantum efficiency (DQE), energy dependence of detector

  4. Toxic chemical release inventory risk screening guide (Version 1. 0). Volume 1. The process. Volume 2. Appendices. Final report

    SciTech Connect

    Klauder, D.; Saunders, L.

    1989-07-01

    The guide describes some of the challenges raised by the Toxic Release Inventory (TRI) data and to suggest ways of approaching them. The guide suggests steps that can be taken to answer two key issues of concern: setting risk-based priorities for followup investigation of the TRI facilities and chemicals within geographic area of interest, and identifying data needs and approaches for collecting information necessary to respond to health and ecological questions from the public. The guide is directed at those individuals who are involved in interpreting and explaining environmental pollution, exposures, and health risks to the general public, especially at the local or sub-State level. Many users of the guide will already be well versed in evaluating risk and/or in helping members of the public understand and deal with toxic chemicals, but Title 111 - particularly, the Section 313 release data - presents new challenges for everyone.

  5. Optimum design calculations for detectors based on ZnSe(Те,О) scintillators

    NASA Astrophysics Data System (ADS)

    Katrunov, K.; Ryzhikov, V.; Gavrilyuk, V.; Naydenov, S.; Lysetska, O.; Litichevskyi, V.

    2013-06-01

    Light collection in scintillators ZnSe(X), where X is an isovalent dopant, was studied using Monte Carlo calculations. Optimum design was determined for detectors of "scintillator—Si-photodiode" type, which can involve either one scintillation element or scintillation layers of large area made of small-crystalline grains. The calculations were carried out both for determination of the optimum scintillator shape and for design optimization of light guides, on the surface of which the layer of small-crystalline grains is formed.

  6. Surface preparation and coupling in plastic scintillator dosimetry

    SciTech Connect

    Ayotte, Guylaine; Archambault, Louis; Gingras, Luc; Lacroix, Frederic; Beddar, A. Sam; Beaulieu, Luc

    2006-09-15

    One way to improve the performance of scintillation dosimeters is to increase the light-collection efficiency at the coupling interfaces of the detector system. We performed a detailed study of surface preparation of scintillating fibers and their coupling with clear optical fibers to minimize light loss and increase the amount of light collected. We analyzed fiber-surface polishing with aluminum oxide sheets, coating fibers with magnesium oxide, and the use of eight different coupling agents (air, three optical gels, an optical curing agent, ultraviolet light, cyanoacrylate glue, and acetone). We prepared 10 scintillating fiber and clear optical fiber light guide samples to test different coupling methods. To test the coupling, we first cut both the scintillating fiber and the clear optical fiber. Then, we cleaned and polished both ends of both fibers. Finally, we coupled the scintillating fiber with the clear optical fiber in either a polyethylene jacket or a V-grooved support depending on the coupling agent used. To produce more light, we used an ultraviolet lamp to stimulate scintillation. A typical series of similar couplings showed a standard deviation in light-collection efficiency of 10%. This can be explained by differences in the surface preparation quality and alignment of the scintillating fiber with the clear optical fiber. Absence of surface polishing reduced the light collection by approximately 40%, and application of magnesium oxide on the proximal end of the scintillating fiber increased the amount of light collected from the optical fiber by approximately 39%. Of the coupling agents, we obtained the best results using one of the optical gels. Because a large amount of the light produced inside a scintillator is usually lost, better light-collection efficiency will result in improved sensitivity.

  7. Surface preparation and coupling in plastic scintillator dosimetry.

    PubMed

    Ayotte, Guylaine; Archambault, Louis; Gingras, Luc; Lacroix, Frédéric; Beddar, A Sam; Beaulieu, Luc

    2006-09-01

    One way to improve the performance of scintillation dosimeters is to increase the light-collection efficiency at the coupling interfaces of the detector system. We performed a detailed study of surface preparation of scintillating fibers and their coupling with clear optical fibers to minimize light loss and increase the amount of light collected. We analyzed fiber-surface polishing with aluminum oxide sheets, coating fibers with magnesium oxide, and the use of eight different coupling agents (air, three optical gels, an optical curing agent, ultraviolet light, cyanoacrylate glue, and acetone). We prepared 10 scintillating fiber and clear optical fiber light guide samples to test different coupling methods. To test the coupling, we first cut both the scintillating fiber and the clear optical fiber. Then, we cleaned and polished both ends of both fibers. Finally, we coupled the scintillating fiber with the clear optical fiber in either a polyethylene jacket or a V-grooved support depending on the coupling agent used. To produce more light, we used an ultraviolet lamp to stimulate scintillation. A typical series of similar couplings showed a standard deviation in light-collection efficiency of 10%. This can be explained by differences in the surface preparation quality and alignment of the scintillating fiber with the clear optical fiber. Absence of surface polishing reduced the light collection by approximately 40%, and application of magnesium oxide on the proximal end of the scintillating fiber increased the amount of light collected from the optical fiber by approximately 39%. Of the coupling agents, we obtained the best results using one of the optical gels. Because a large amount of the light produced inside a scintillator is usually lost, better light-collection efficiency will result in improved sensitivity. PMID:17022248

  8. Boron loaded scintillator

    SciTech Connect

    Bell, Zane William; Brown, Gilbert Morris; Maya, Leon; Sloop, Jr., Frederick Victor; Sloop, Jr., Frederick Victor

    2009-10-20

    A scintillating composition for detecting neutrons and other radiation comprises a phenyl containing silicone rubber with carborane units and at least one phosphor molecule. The carbonate units can either be a carborane molecule dispersed in the rubber with the aid of a compatibilization agent or can be covalently bound to the silicone.

  9. Polysiloxane scintillator composition

    DOEpatents

    Walker, J.K.

    1992-05-05

    A plastic scintillator useful for detecting ionizing radiation comprising a matrix which comprises an optically transparent polysiloxane having incorporated therein at least one ionizing radiation-hard fluor capable of converting electromagnetic energy produced in the polysiloxane upon absorption of ionizing radiation to detectable light.

  10. SCINTILLATION EXPOSURE RATE DETECTOR

    DOEpatents

    Spears, W.G.

    1960-11-01

    A radiation detector for gamma and x rays is described. The detector comprises a scintillation crystal disposed between a tantalum shield and the input of a photomultiplier tube, the crystal and the shield cooperating so that their combined response to a given quantity of radiation at various energy levels is substantially constant.

  11. Polysiloxane scintillator composition

    DOEpatents

    Walker, James K.

    1992-01-01

    A plastic scintillator useful for detecting ionizing radiation comprising a matrix which comprises an optically transparent polysiloxane having incorporated therein at least one ionizing radiation-hard fluor capable of converting electromagnetic energy produced in the polysiloxane upon absorption of ionizing radiation to detectable light.

  12. High Latitude Scintillations during the ICI-4 Rocket Campaign.

    NASA Astrophysics Data System (ADS)

    Patra, S.; Moen, J.

    2015-12-01

    We present the first results from the Norwegian ICI-4 sounding rocket campaign in February 2015. The ICI-4 was launched into F-region auroral blobs from the Andøya Space Center. The multi needle langmuir probe (m-NLP) on board the rocket sampled the ionospheric density structures at a sub-meter spatial resolution. A multi-phase screen model has been developed to estimate the scintillations from the density measurements acquired on-board spacecrafts. The phase screen model is validated and the comparison of the estimated values with scintillations measured by ground receivers during the campaign will be presented. A combination of scintillation receivers in Svalbard and surrounding areas as well as all sky imagers at Ny Ålesund, Longyerbyen, and Skibotn are used to improve the performance of the model.

  13. Scintillator requirements for medical imaging

    SciTech Connect

    Moses, William W.

    1999-09-01

    Scintillating materials are used in a variety of medical imaging devices. This paper presents a description of four medical imaging modalities that make extensive use of scintillators: planar x-ray imaging, x-ray computed tomography (x-ray CT), SPECT (single photon emission computed tomography) and PET (positron emission tomography). The discussion concentrates on a description of the underlying physical principles by which the four modalities operate. The scintillator requirements for these systems are enumerated and the compromises that are made in order to maximize imaging performance utilizing existing scintillating materials are discussed, as is the potential for improving imaging performance by improving scintillator properties.

  14. Scintillator Waveguide For Sensing Radiation

    DOEpatents

    Bliss, Mary; Craig, Richard A.; Reeder; Paul L.

    2003-04-22

    The present invention is an apparatus for detecting ionizing radiation, having: a waveguide having a first end and a second end, the waveguide formed of a scintillator material wherein the therapeutic ionizing radiation isotropically generates scintillation light signals within the waveguide. This apparatus provides a measure of radiation dose. The apparatus may be modified to permit making a measure of location of radiation dose. Specifically, the scintillation material is segmented into a plurality of segments; and a connecting cable for each of the plurality of segments is used for conducting scintillation signals to a scintillation detector.

  15. Revisiting the Wilson-Jungner criteria: How can supplemental criteria guide public health in the era of genetic screening?

    PubMed

    Petros, Michael

    2011-10-01

    PURPOSE:: Advances in technology have made newborn screening for more than 50 inborn errors of metabolism possible using a dried blood sample. A framework is proposed that public health practitioners may use when considering candidate disorders for newborn screening panels. METHODS:: The framework expands on the 10 Wilson-Jungner criteria with the addition of 11 criteria specific to newborn screening. A calculation, the "pNBS Decision Score," is used to quantify results and rank candidate disorders. RESULTS:: The pNBS Decision Scores that were calculated for phenylketonuria (OMIM# 261600), cystic fibrosis (OMIM# 219700), Pompe disease (OMIM# 232300), and severe combined immunodeficiency (OMIM# 102700) support their inclusion as newborn screening disorders. The pNBS Decision Score suggests that Krabbe disease (OMIM# 245200) is not a candidate disorder for inclusion at this time. CONCLUSION:: The proposed framework adds to the ability of policy makers to quantify an essential portion of the process for adding disorders to newborn screening panels. Other factors such as ethical, legal, and social issues, clinical utility, and advocacy are also part of the policy process. The framework is not intended to replace existing nomination processes but rather to enhance those processes by encouraging iterative review of newborn screening-specific criteria. The use of the framework will provide consistency across a portion of the decision process. The public health community should take the opportunity to revisit the screening determinants of the Wilson-Jungner criteria from a 21st century perspective. The results suggest that this framework provides the public health practitioner with a consistent process for making an evidence-based decision. PMID:21983595

  16. Laser beam scintillation beyond the turbulent atmosphere A numerical computation

    NASA Technical Reports Server (NTRS)

    Bufton, J. L.; Taylor, L. S.

    1976-01-01

    The extended Huygens-Fresnel formulation for propagation through turbulence is used to examine scintillation of a finite laser beam. The method is demonstrated analytically for propagation beyond a weak Gaussian phase screen. A numerical integration technique is used to extend the results to a more realistic turbulence model. Results are compared with existing Gaussian beam propagation theory.

  17. Intensity Scintillations in Planetary Ring Occultations: Simulations

    NASA Astrophysics Data System (ADS)

    Marouf, E.

    2003-12-01

    A combined analytical and numerical simulation approach is used to investigate the first, second, and fourth statistical averages of the signal observed during a ring occultation experiment. The rings are modeled as a randomly blocked diffraction screen. The field behind the screen (the rings) assumes binary values: zero if located in the shadow area cast by ring particles and the full incident field otherwise. The stochastic geometry of the union of shadow areas cast behind the rings defines a so-called Boolean model. Either the random wavefront formed behind the screen or it's statistical averages can be propagated to an observer (a detector) some distance away from the diffraction screen. The parabolic approximation of the wave equation is used to model near-forward diffraction effects over the free-space path from the ring plane to the observation plane. The first and second moments were previously shown to correspond to the well-known coherent and scattered signal components observed during radio occultation experiments. Of particular interest here is the fourth moment of the random field at the observer, which determines the intensity scintillation index. Numerical simulations are used to investigate its behavior as a function of relevant model parameters, in particular, the ring particle radius and the Fresnel scale of observation. A monodispersion of ring particles is assumed to keep the model as simple as possible so as to investigate conditions under which the particle size may be recoverable from the intensity scintillation measurements. The model is also idealized to one-dimensional diffraction screen in order to speed up the computations; however, simulations of the more realistic two-dimensional diffraction screen models are also carried out.

  18. Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries.

    PubMed

    Körbelin, Jakob; Sieber, Timo; Michelfelder, Stefan; Lunding, Lars; Spies, Elmar; Hunger, Agnes; Alawi, Malik; Rapti, Kleopatra; Indenbirken, Daniela; Müller, Oliver J; Pasqualini, Renata; Arap, Wadih; Kleinschmidt, Jürgen A; Trepel, Martin

    2016-06-01

    Vectors mediating strong, durable, and tissue-specific transgene expression are mandatory for safe and effective gene therapy. In settings requiring systemic vector administration, the availability of suited vectors is extremely limited. Here, we present a strategy to select vectors with true specificity for a target tissue from random peptide libraries displayed on adeno-associated virus (AAV) by screening the library under circulation conditions in a murine model. Guiding the in vivo screening by next-generation sequencing, we were able to monitor the selection kinetics and to determine the right time point to discontinue the screening process. The establishment of different rating scores enabled us to identify the most specifically enriched AAV capsid candidates. As proof of concept, a capsid variant was selected that specifically and very efficiently delivers genes to the endothelium of the pulmonary vasculature after intravenous administration. This technical approach of selecting target-specific vectors in vivo is applicable to any given tissue of interest and therefore has broad implications in translational research and medicine. PMID:27018516

  19. A Guide to Administration, Diagnosis, and Treatment for the Early and Periodic Screening, Diagnosis, and Treatment Program (EPSDT) Under Medicaid.

    ERIC Educational Resources Information Center

    Hass, Gerald; Scovell, Melvin

    Provided are guidelines on administration, diagnosis, and treatment in federally funded EPSDT--Early and Periodic Screening, Diagnosis, and Treatment Programs, a system for providing health care services to Medicaid-eligible children. Detailed in part one are factors involved in developing EPSDT programs. Four chapters consider the need for EPSDT,…

  20. OPTIMAL WELL LOCATOR (OWL): A SCREENING TOOL FOR EVALUATING LOCATIONS OF MONITORING WELLS: USER'S GUIDE VERSION 1.2

    EPA Science Inventory

    The Optimal Well Locator ( OWL) program was designed and developed by USEPA to be a screening tool to evaluate and optimize the placement of wells in long term monitoring networks at small sites. The first objective of the OWL program is to allow the user to visualize the change ...

  1. What ethical and legal principles should guide the genotyping of children as part of a personalised screening programme for common cancer?

    PubMed

    Hall, Alison Elizabeth; Chowdhury, Susmita; Pashayan, Nora; Hallowell, Nina; Pharoah, Paul; Burton, Hilary

    2014-03-01

    Increased knowledge of the gene-disease associations contributing to common cancer development raises the prospect of population stratification by genotype and other risk factors. Individual risk assessments could be used to target interventions such as screening, treatment and health education. Genotyping neonates, infants or young children as part of a systematic programme would improve coverage and uptake, and facilitate a screening package that maximises potential benefits and minimises harms including overdiagnosis. This paper explores the potential justifications and risks of genotyping children for genetic variants associated with common cancer development within a personalised screening programme. It identifies the ethical and legal principles that might guide population genotyping where the predictive value of the testing is modest and associated risks might arise in the future, and considers the standards required by population screening programme validity measures (such as the Wilson and Jungner criteria including cost-effectiveness and equitable access). These are distinguished from the normative principles underpinning predictive genetic testing of children for adult-onset diseases-namely, to make best-interests judgements and to preserve autonomy. While the case for population-based genotyping of neonates or young children has not yet been made, the justifications for this approach are likely to become increasingly compelling. A modified evaluative and normative framework should be developed, capturing elements from individualistic and population-based approaches. This should emphasise proper communication and genuine parental consent or informed choice, while recognising the challenges associated with making unsolicited approaches to an asymptomatic group. Such a framework would be strengthened by complementary empirical research. PMID:23454719

  2. A screening algorithm for diagnosing bacterial gastroenteritis by real-time PCR in combination with guided culture.

    PubMed

    Van Lint, P; De Witte, E; Ursi, J P; Van Herendael, B; Van Schaeren, J

    2016-06-01

    We have introduced a real-time PCR for the simultaneous detection of Campylobacter jejuni, Salmonella spp., Shigella spp./enteroinvasive Escherichia coli and Yersinia enterocolitica in fecal samples in our routine laboratory. This new approach showed consistent results, with minimal inter-sample variation. When compared to conventional culture, the hands-on time decreased by 13 h/wk, and the median turnaround time drastically shortened from 73 to 29 h (P < .0001). Moreover, the detection rate of the targeted pathogens seemed to increase: the positivity rate registered over a twelve month period increased from 4.98% when using bacterial culture, compared to 8.56% when using real-time PCR (P < .0001). For antimicrobial susceptibility testing, samples that are found to be PCR positive are additionally cultured after the PCR result is known. Using this algorithm, we got a positive culture for 71.0% of the PCR positive samples. The samples missed by guided culture had significantly higher quantification cycle (Cq) values compared to the samples picked up by guided culture (P = .0003). Finally; we also tested the effect of extended sample storage on the performance of guided culture. Storage time prior to inoculation did have an effect on the positivity rate of culture; interestingly, these effects were clearly species-dependent. PMID:27107537

  3. New scintillator and waveshifter materials

    SciTech Connect

    Zheng, H.; Baumbaugh, B.; Gerig, A.; Marchant, J.; Reynolds, K.; Ruchti, R.; Warchol, J; Wayne, M. Hurlbut, C. Kauffman, J. Pla-Dalmau, A.

    1998-11-01

    Experimental applications requiring fast timing and/or high efficiency position and energy measurements typically use scintillation materials. Scintillators utilized for triggering, tracking, and calorimetry in colliding beam detectors are vulnerable to the high radiation fields associated with such experiments. We have begun an investigation of several fluorescent dyes which might lead to fast, efficient, and radiation resistant scintillators. Preliminary results of spectral analysis and efficiency are presented. {copyright} {ital 1998 American Institute of Physics.}

  4. Lunar components in Lunping scintillations

    SciTech Connect

    Koster, J.R.; Lue, H.Y.; Wu, Hsi-Shu; Huang, Yinn-Nien

    1993-08-01

    The authors report on an anlysis of a 14 year data set of ionospheric scintillation data for 136 MHz signals transmitted from a Japanese satellite. They use a lunar age superposition method to analyze this data, breaking the data into blocks by seasons of the year. They observe a number of different scintillation types in the record, as well as impacts of lunar tides on the time record. They attempt to provide an origin for the different scintillation types.

  5. A computer model of high-latitude scintillation

    NASA Astrophysics Data System (ADS)

    Fremouw, E. J.

    1982-01-01

    The DNA Wideband satellite experiment provided extensive data on scintillation produced in high-altitude structured plasmas. A computer program, WBMOD, is being developed to summarize those data in an applications-oriented way. The program contains the phase-screen scattering theory of Rino and a morphological description of ionospheric irregularities (thus far only at auroral latitudes) based on Wideband observations. It permits a user to compute scintillation indices for both phase and intensity as a function of system operating parameters and solar-ionospheric disturbance level. Correction is made for multiple scatter, and the user may choose either one-way (communication) or two-way (radar) propagation.

  6. Computer model of high-latitude scintillation. [WBMOD program

    SciTech Connect

    Fremouw, E.J.

    1982-01-01

    The DNA Wideband satellite experiment provided extensive data on scintillation produced in high-altitude structured plasmas. A computer program, WBMOD, is being developed to summarize those data in an applications-oriented way. The program contains the phase-screen scattering theory of Rino and a morphological description of ionospheric irregularities (thus far only at auroral latitudes) based on Wideband observations. It permits a user to compute scintillation indices for both phase and intensity as a function of system operating parameters and solar-ionospheric disturbance level. Correction is made for multiple scatter, and the user may choose either one-way (communication) or two-way (radar) propagation.

  7. Coherence properties of wideband satellite signals caused by ionospheric scintillation

    NASA Technical Reports Server (NTRS)

    Rufenach, C. L.

    1975-01-01

    Radio scintillation on satellite signals caused by small-scale irregularities in F-region ionospheric electron density can be an important limitation on earth-satellite communication and navigation systems. Scintillation imposes distortion in both amplitude and phase on wideband signals. In the present work, the shallow-modulated phase screen theory is developed in terms of coherence bandwidth including a model based on a turbulent-like power-law description of the irregularities. The model results usually show a greater coherence bandwidth in the signal phase than in the signal amplitude. Therefore, systems that require phase coherence over a large bandwidth should be less affected than those requiring amplitude coherence.

  8. Dual targets guided screening and isolation of Kukoamine B as a novel natural anti-sepsis agent from traditional Chinese herb Cortex lycii.

    PubMed

    Liu, Xin; Zheng, Xinchuan; Long, Yupeng; Cao, Hongwei; Wang, Ning; Lu, Yongling; Zhao, Kecen; Zhou, Hong; Zheng, Jiang

    2011-01-01

    Treating sepsis remains challenging at present. Bacterial lipopolysaccharide (LPS) and bacterial DNA/CpG DNA are important pathogenic molecules and drug targets for sepsis. It is thus a promising strategy to treat sepsis by discovering agents that neutralize LPS and CpG DNA simultaneously. In this study, we present evidences of the biosensor based screening and isolation of active anti-sepsis fractions and monomers from traditional Chinese herbs using dual targets (LPS and CpG DNA) guided drug discovery strategy. Firstly, LPS or CpG DNA was immobilized on surfaces of cuvettes in the biosensor to establish a screening platform. Then, Cortex lycii with both highest affinities was selected out from one hundred and fourteen traditional Chinese herbs. In subsequent experiments, chromatography was utilized and coupled with the biosensor to purify fractions with a higher affinity for LPS and CpG DNA. In line with affinity assay, these fractions were shown to neutralize LPS and CpG DNA and inhibit their activity in vitro and in vivo. Lastly, the contributing monomer Kukoamine B (KB) was purified. KB neutralized LPS and CpG DNA in vitro. It inhibited TLR4, TLR9 and MyD88 mRNA expressions up-regulated by LPS and CpG DNA, and also attenuated the LPS and CpG DNA elicited nuclear translocation of NF-κB p65 protein in RAW264.7 cells. It also protected mice from lethal challenge of heat-killed E. coli, a mixture of LPS and CpG DNA. In conclusion, we presented a dual target guided discovery of a novel anti-sepsis agent KB from traditional Chinese herbs via combination of biosensor technology and chromatography methods. PMID:21073991

  9. A plastic scintillation counter prototype.

    PubMed

    Furuta, Etsuko; Kawano, Takao

    2015-10-01

    A new prototype device for beta-ray measurement, a plastic scintillation counter, was assembled as an alternative device to liquid scintillation counters. This device uses plastic scintillation sheets (PS sheets) as a sample applicator without the use of a liquid scintillator. The performance was evaluated using tritium labeled compounds, and good linearity was observed between the activity and net count rate. The calculated detection limit of the device was 0.01 Bq mL(-1) after 10 h measurement for 2 mL sample. PMID:26164628

  10. Statistical analysis of scintillation data

    SciTech Connect

    Chua, S.; Noonan, J.P.; Basu, S.

    1981-09-01

    The Nakagami-m distribution has traditionally been used successfully to model the probability characteristics of ionospheric scintillations at UHF. This report investigates the distribution properties of scintillation data in the L-band range. Specifically, the appropriateness of the Nakagami-m and lognormal distributions is tested. Briefly the results confirm that the Nakagami-m is appropriate for UHF but not for L-band scintillations. The lognormal provides a better fit to the distribution of L-band scintillations and is an adequate model allowing for an error of + or - 0.1 or smaller in predicted probability with a sample size of 256.

  11. Cas-Database: web-based genome-wide guide RNA library design for gene knockout screens using CRISPR-Cas9

    PubMed Central

    Park, Jeongbin; Kim, Jin-Soo; Bae, Sangsu

    2016-01-01

    Motivation: CRISPR-derived RNA guided endonucleases (RGENs) have been widely used for both gene knockout and knock-in at the level of single or multiple genes. RGENs are now available for forward genetic screens at genome scale, but single guide RNA (sgRNA) selection at this scale is difficult. Results: We develop an online tool, Cas-Database, a genome-wide gRNA library design tool for Cas9 nucleases from Streptococcus pyogenes (SpCas9). With an easy-to-use web interface, Cas-Database allows users to select optimal target sequences simply by changing the filtering conditions. Furthermore, it provides a powerful way to select multiple optimal target sequences from thousands of genes at once for the creation of a genome-wide library. Cas-Database also provides a web application programming interface (web API) for advanced bioinformatics users. Availability and implementation: Free access at http://www.rgenome.net/cas-database/. Contact: sangsubae@hanyang.ac.kr or jskim01@snu.ac.kr Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27153724

  12. The effect of scintillator response on signal difference to noise ratio in X-ray medical imaging

    NASA Astrophysics Data System (ADS)

    Ninos, K.; Cavouras, D.; Fountos, G.; Kandarakis, I.

    2010-10-01

    The aim of the present study was to examine the effect of scintillator material properties on the signal difference to noise ratio (SdNR) under X-ray imaging conditions. To this aim, SdNR was modelled in terms of scintillator material properties such as the quantum detection efficiency (QDE), the intrinsic energy conversion efficiency (ICE) and the light transmission efficiency (LTE). Scintillators were assumed to be in the form of scintillator layers (phosphor screens) with various thicknesses ranging from 70 to 110 mg/cm2. Data on the X-ray absorption and optical properties of the scintillators were either calculated from tabulated data, i.e. X-ray attenuation coefficients for QDE estimation, or were obtained from previous experimental studies. It was found that in a wide range of X-ray tube voltages the Gd2O2S:Tb scintillator produced higher SdNR values, while the CsI:Tl scintillator was better at lower voltages (below 65 kVp). It was additionally verified that, in the range of X-ray diagnostic energies, SdNR increases with the thickness of the scintillator layer screen. In conclusion, SdNR may be critically affected by scintillator properties and, hence, it may be significantly improved by appropriately selecting the type and thickness of the phosphor screen to be integrated into an imaging system.

  13. Screening for Social Determinants of Health Among Children and Families Living in Poverty: A Guide for Clinicians.

    PubMed

    Chung, Esther K; Siegel, Benjamin S; Garg, Arvin; Conroy, Kathleen; Gross, Rachel S; Long, Dayna A; Lewis, Gena; Osman, Cynthia J; Jo Messito, Mary; Wade, Roy; Shonna Yin, H; Cox, Joanne; Fierman, Arthur H

    2016-05-01

    Approximately 20% of all children in the United States live in poverty, which exists in rural, urban, and suburban areas. Thus, all child health clinicians need to be familiar with the effects of poverty on health and to understand associated, preventable, and modifiable social factors that impact health. Social determinants of health are identifiable root causes of medical problems. For children living in poverty, social determinants of health for which clinicians may play a role include the following: child maltreatment, child care and education, family financial support, physical environment, family social support, intimate partner violence, maternal depression and family mental illness, household substance abuse, firearm exposure, and parental health literacy. Children, particularly those living in poverty, exposed to adverse childhood experiences are susceptible to toxic stress and a variety of child and adult health problems, including developmental delay, asthma and heart disease. Despite the detrimental effects of social determinants on health, few child health clinicians routinely address the unmet social and psychosocial factors impacting children and their families during routine primary care visits. Clinicians need tools to screen for social determinants of health and to be familiar with available local and national resources to address these issues. These guidelines provide an overview of social determinants of health impacting children living in poverty and provide clinicians with practical screening tools and resources. PMID:27101890

  14. Free liquid scintillation counting bibliography

    SciTech Connect

    1996-12-31

    Packard Instrument Company announces the availability of its newly updated Bibliography of Packard Tri-Carb Liquid Scintillation Analyzers. This unique new booklet lists 628 references in which Packard Tri-Carb{reg_sign} liquid scintillation analyzers have been used in life science, environmental, nuclear power and archaeological measurements. All listings are cross-referenced by radionuclide, specific field of study and author.

  15. Lithium-loaded liquid scintillators

    DOEpatents

    Dai, Sheng; Kesanli, Banu; Neal, John S.

    2012-05-15

    The invention is directed to a liquid scintillating composition containing (i) one or more non-polar organic solvents; (ii) (lithium-6)-containing nanoparticles having a size of up to 10 nm and surface-capped by hydrophobic molecules; and (iii) one or more fluorophores. The invention is also directed to a liquid scintillator containing the above composition.

  16. Development of radiation hard scintillators

    NASA Astrophysics Data System (ADS)

    Markley, F.; Davidson, M.; Keller, J.; Foster, G.; Pla-Dalmau, A.; Harmon, J.; Biagtan, E.; Schueneman, G.; Senchishin, V.; Gustfason, H.

    1993-11-01

    The authors have demonstrated that the radiation stability of scintillators made from styrene polymer is very much improved by compounding with pentaphenyl trimethyl trisiloxane (DC 705 vacuum pump oil). The resulting scintillators are softer than desired, so they decided to make the scintillators directly from monomer where the base resin could be easily crosslinked to improve the mechanical properties. They can now demonstrate that scintillators made directly from the monomer, using both styrene and 4-methyl styrene, are also much more radiation resistant when modified with DC705 oil. In fact, they retain from 92% to 95% of their original light output after gamma irradiation to 10 Mrads in nitrogen with air annealing. When these scintillators made directly from monomer are compared with scintillators of the same composition made from polymer the latter have much higher light outputs. They commonly reach 83% while those made from monomer give only 50% to 60% relative to the reference, BC408. When oil modified scintillators using both p-terphenyl and tetra phenyl butadiene are compared with identical scintillators except that they use 3 hydroxy-flavone as the only luminophore the radiation stability is the same. However the 3HF system gives only 30% as much light as BC408 instead of 83% when both are measured with a green extended Phillips XP2081B phototube.

  17. Extruding plastic scintillator at Fermilab

    SciTech Connect

    Anna Pla-Dalmau; Alan D. Bross; Victor V. Rykalin

    2003-10-31

    An understanding of the costs involved in the production of plastic scintillators and the development of a less expensive material have become necessary with the prospects of building very large plastic scintillation detectors. Several factors contribute to the high cost of plastic scintillating sheets, but the principal reason is the labor-intensive nature of the manufacturing process. In order to significantly lower the costs, the current casting procedures had to be abandoned. Since polystyrene is widely used in the consumer industry, the logical path was to investigate the extrusion of commercial-grade polystyrene pellets with dopants to yield high quality plastic scintillator. This concept was tested and high quality extruded plastic scintillator was produced. The D0 and MINOS experiments are already using extruded scintillator strips in their detectors. An extrusion line has recently been installed at Fermilab in collaboration with NICADD (Northern Illinois Center for Accelerator and Detector Development). This new facility will serve to further develop and improve extruded plastic scintillator. This paper will discuss the characteristics of extruded plastic scintillator and its raw materials, the different manufacturing techniques and the current R&D program at Fermilab.

  18. Development of radiation hard scintillators

    SciTech Connect

    Markley, F.; Davidson, M.; Keller, J.; Foster, G.; Pla-Dalmau, A.; Harmon, J.; Biagtan, E.; Schueneman, G.; Senchishin, V.; Gustfason, H.; Rivard, M.

    1993-11-01

    The authors have demonstrated that the radiation stability of scintillators made from styrene polymer is very much improved by compounding with pentaphenyltrimethyltrisiloxane (DC 705 vacuum pump oil). The resulting scintillators are softer than desired, so they decided to make the scintillators directly from monomer where the base resin could be easily crosslinked to improve the mechanical properties. They can now demonstrate that scintillators made directly from the monomer, using both styrene and 4-methyl styrene, are also much more radiation resistant when modified with DC705 oil. In fact, they retain from 92% to 95% of their original light output after gamma irradiation to 10 Mrads in nitrogen with air annealing. When these scintillators made directly from monomer are compared with scintillators of the same composition made from polymer the latter have much higher light outputs. They commonly reach 83% while those made form monomer give only 50% to 60% relative to the reference, BC408. When oil modified scintillators using both p-terphenyl and tetraphenylbutadiene are compared with identical scintillators except that they use 3 hydroxy-flavone as the only luminophore the radiation stability is the same. However the 3HF system gives only 30% as much light as BC408 instead of 83% when both are measured with a green extended Phillips XP2081B phototube.

  19. Hybrid scintillators for neutron discrimination

    DOEpatents

    Feng, Patrick L; Cordaro, Joseph G; Anstey, Mitchell R; Morales, Alfredo M

    2015-05-12

    A composition capable of producing a unique scintillation response to neutrons and gamma rays, comprising (i) at least one surfactant; (ii) a polar hydrogen-bonding solvent; and (iii) at least one luminophore. A method including combining at least one surfactant, a polar hydrogen-bonding solvent and at least one luminophore in a scintillation cell under vacuum or an inert atmosphere.

  20. Development of intrinsic IPT scintillator

    SciTech Connect

    Bross, A.D.

    1989-07-31

    We report on the development of a new polystyrene based plastic scintillator. Optical absorption, fluorescence and light output measurements are presented. Preliminary results of radiation damage effects are also given and compared to the effects on a commercial plastic scintillator, NE 110. 6 refs., 12 figs.

  1. A fast microchannel plate-scintillator detector for velocity map imaging and imaging mass spectrometry

    SciTech Connect

    Winter, B.; King, S. J.; Vallance, C.; Brouard, M.

    2014-02-15

    The time resolution achievable using standard position-sensitive ion detectors, consisting of a chevron pair of microchannel plates coupled to a phosphor screen, is primarily limited by the emission lifetime of the phosphor, around 70 ns for the most commonly used P47 phosphor. We demonstrate that poly-para-phenylene laser dyes may be employed extremely effectively as scintillators, exhibiting higher brightness and much shorter decay lifetimes than P47. We provide an extensive characterisation of the properties of such scintillators, with a particular emphasis on applications in velocity-map imaging and microscope-mode imaging mass spectrometry. The most promising of the new scintillators exhibits an electron-to-photon conversion efficiency double that of P47, with an emission lifetime an order of magnitude shorter. The new scintillator screens are vacuum stable and show no signs of signal degradation even over longer periods of operation.

  2. Proton recoil scintillator neutron rem meter

    DOEpatents

    Olsher, Richard H.; Seagraves, David T.

    2003-01-01

    A neutron rem meter utilizing proton recoil and thermal neutron scintillators to provide neutron detection and dose measurement. In using both fast scintillators and a thermal neutron scintillator the meter provides a wide range of sensitivity, uniform directional response, and uniform dose response. The scintillators output light to a photomultiplier tube that produces an electrical signal to an external neutron counter.

  3. Extended algorithm for simulation of light transport in single crystal scintillation detectors for S(T)EM.

    PubMed

    Schauer, Petr

    2007-01-01

    The new extended Monte Carlo (MC) simulation method for photon transport in S(T)EM back scattered electron (BSE) scintillation detection systems of various shapes is presented in this paper. The method makes use of the random generation of photon emission from a scintillator luminescent centre and describes the trajectory of photons and the efficiency of their transport toward the photocathode of the photomultiplier tube. The paper explains a new algorithm for determining the position of interaction of the photon with the surface of the single crystal scintillator or of the light guide with nearly arbitrary shapes. Some examples of the utilization of the simulation method are also included, and conclusions for very simple edge-guided signal (EGS) scintillation detection systems made. The computer optimized design of the BSE scintillation detector for the S 4000 Hitachi SEM was chosen to demonstrate the capability of this MC simulation method. PMID:17957744

  4. Ionospheric scintillation studies

    NASA Technical Reports Server (NTRS)

    Rino, C. L.; Freemouw, E. J.

    1973-01-01

    The diffracted field of a monochromatic plane wave was characterized by two complex correlation functions. For a Gaussian complex field, these quantities suffice to completely define the statistics of the field. Thus, one can in principle calculate the statistics of any measurable quantity in terms of the model parameters. The best data fits were achieved for intensity statistics derived under the Gaussian statistics hypothesis. The signal structure that achieved the best fit was nearly invariant with scintillation level and irregularity source (ionosphere or solar wind). It was characterized by the fact that more than 80% of the scattered signal power is in phase quadrature with the undeviated or coherent signal component. Thus, the Gaussian-statistics hypothesis is both convenient and accurate for channel modeling work.

  5. Properties of scintillator solutes

    SciTech Connect

    Fluornoy, J.M.

    1998-06-01

    This special report summarizes measurements of the spectroscopic and other properties of the solutes that were used in the preparation of several new liquid scintillators developed at EG and G/Energy Measurements/Santa Barbara Operations (the precursor to Bechtel Nevada/Special Technologies Laboratory) on the radiation-to-light converter program. The data on the individual compounds are presented in a form similar to that used by Prof. Isadore Berlman in his classic handbook of fluorescence spectra. The temporal properties and relative efficiencies of the new scintillators are presented in Table 1, and the efficiencies as a function of wavelength are presented graphically in Figure 1. In addition, there is a descriptive glossary of the abbreviations used herein. Figure 2 illustrates the basic structures of some of the compounds and of the four solvents reported in this summary. The emission spectra generally exhibit more structure than the absorption spectra, with the result that the peak emission wavelength for a given compound may lie several nm away from the wavelength, {lambda}{sub avg}, at the geometric center of the emission spectrum. Therefore, the author has chosen to list absorption peaks, {lambda}{sub max}, and emission {lambda}{sub avg} values in Figures 3--30, as being most illustrative of the differences between the compounds. The compounds, BHTP, BTPB, ADBT, and DPTPB were all developed on this program. P-terphenyl, PBD, and TPB are commercially available blue emitters. C-480 and the other longer-wavelength emitters are laser dyes available commercially from Exciton Corporation. 1 ref., 30 figs.

  6. A theory of scintillation for two-component power law irregularity spectra: Overview and numerical results

    NASA Astrophysics Data System (ADS)

    Carrano, Charles S.; Rino, Charles L.

    2016-06-01

    We extend the power law phase screen theory for ionospheric scintillation to account for the case where the refractive index irregularities follow a two-component inverse power law spectrum. The two-component model includes, as special cases, an unmodified power law and a modified power law with spectral break that may assume the role of an outer scale, intermediate break scale, or inner scale. As such, it provides a framework for investigating the effects of a spectral break on the scintillation statistics. Using this spectral model, we solve the fourth moment equation governing intensity variations following propagation through two-dimensional field-aligned irregularities in the ionosphere. A specific normalization is invoked that exploits self-similar properties of the structure to achieve a universal scaling, such that different combinations of perturbation strength, propagation distance, and frequency produce the same results. The numerical algorithm is validated using new theoretical predictions for the behavior of the scintillation index and intensity correlation length under strong scatter conditions. A series of numerical experiments are conducted to investigate the morphologies of the intensity spectrum, scintillation index, and intensity correlation length as functions of the spectral indices and strength of scatter; retrieve phase screen parameters from intensity scintillation observations; explore the relative contributions to the scintillation due to large- and small-scale ionospheric structures; and quantify the conditions under which a general spectral break will influence the scintillation statistics.

  7. Scintillator materials containing lanthanum fluorides

    DOEpatents

    Moses, W.W.

    1991-05-14

    An improved radiation detector containing a crystalline mixture of LaF[sub 3] and CeF[sub 3] as the scintillator element is disclosed. Scintillators made with from 25% to 99.5% LaF[sub 3] and the remainder CeF[sub 3] have been found to provide a balance of good stopping power, high light yield and short decay constant that is equal to or superior to other known scintillator materials, and which may be processed from natural starting materials containing both rare earth elements. The radiation detectors disclosed are favorably suited for use in general purpose detection and in positron emission tomography. 2 figures.

  8. Scintillator materials containing lanthanum fluorides

    DOEpatents

    Moses, William W.

    1991-01-01

    An improved radiation detector containing a crystalline mixture of LaF.sub.3 and CeF.sub.3 as the scintillator element is disclosed. Scintillators made with from 25% to 99.5% LaF.sub.3 and the remainder CeF.sub.3 have been found to provide a balance of good stopping power, high light yield and short decay constant that is equal to or superior to other known scintillator materials, and which may be processed from natural starting materials containing both rare earth elements. The radiation detectors disclosed are favorably suited for use in general purpose detection and in positron emission tomography.

  9. Scintillator fiber optic long counter

    DOEpatents

    McCollum, Tom; Spector, Garry B.

    1994-01-01

    A flat response position sensitive neutron detector capable of providing neutron spectroscopic data utilizing scintillator fiber optic filaments embedded in a neutron moderating housing having an open end through which neutrons enter to be detected.

  10. Scintillator fiber optic long counter

    DOEpatents

    McCollum, T.; Spector, G.B.

    1994-03-29

    A flat response position sensitive neutron detector capable of providing neutron spectroscopic data utilizing scintillator fiber optic filaments embedded in a neutron moderating housing having an open end through which neutrons enter to be detected is described. 11 figures.

  11. Photon statistics in scintillation crystals

    NASA Astrophysics Data System (ADS)

    Bora, Vaibhav Joga Singh

    Scintillation based gamma-ray detectors are widely used in medical imaging, high-energy physics, astronomy and national security. Scintillation gamma-ray detectors are eld-tested, relatively inexpensive, and have good detection eciency. Semi-conductor detectors are gaining popularity because of their superior capability to resolve gamma-ray energies. However, they are relatively hard to manufacture and therefore, at this time, not available in as large formats and much more expensive than scintillation gamma-ray detectors. Scintillation gamma-ray detectors consist of: a scintillator, a material that emits optical (scintillation) photons when it interacts with ionization radiation, and an optical detector that detects the emitted scintillation photons and converts them into an electrical signal. Compared to semiconductor gamma-ray detectors, scintillation gamma-ray detectors have relatively poor capability to resolve gamma-ray energies. This is in large part attributed to the "statistical limit" on the number of scintillation photons. The origin of this statistical limit is the assumption that scintillation photons are either Poisson distributed or super-Poisson distributed. This statistical limit is often dened by the Fano factor. The Fano factor of an integer-valued random process is dened as the ratio of its variance to its mean. Therefore, a Poisson process has a Fano factor of one. The classical theory of light limits the Fano factor of the number of photons to a value greater than or equal to one (Poisson case). However, the quantum theory of light allows for Fano factors to be less than one. We used two methods to look at the correlations between two detectors looking at same scintillation pulse to estimate the Fano factor of the scintillation photons. The relationship between the Fano factor and the correlation between the integral of the two signals detected was analytically derived, and the Fano factor was estimated using the measurements for SrI2:Eu, YAP

  12. About NICADD extruded scintillating strips

    SciTech Connect

    Dyshkant, A.; Beznosko, D.; Blazey, G.; Chakraborty, D.; Francis, K.; Kubik, D.; Lima, J.G.; Rykalin, V.; Zutshi, v.; Baldina, E.; Bross, A.; Deering, P.; Nebel, T.; Pla-Dalmau, A.; Schellpfeffer, J.; Serritella, C.; Zimmerman, J.; /Fermilab

    2005-04-01

    The results of control measurements of extruded scintillating strip responses to a radioactive source Sr-90 are provided, and details of strip choice, preparation, and method of measurement are included. About four hundred one meter long extruded scintillating strips were measured at four different points. These results were essential for prototyping a tail catcher and muon tracker for a future international electron positron linear collider detector.

  13. Ionospheric Scintillation Effects on GPS

    NASA Astrophysics Data System (ADS)

    Steenburgh, R. A.; Smithtro, C.; Groves, K.

    2007-12-01

    . Ionospheric scintillation of Global Positioning System (GPS) signals threatens navigation and military operations by degrading performance or making GPS unavailable. Scintillation is particularly active, although not limited to, a belt encircling the earth within 20 degrees of the geomagnetic equator. As GPS applications and users increases, so does the potential for detrimental impacts from scintillation. We examined amplitude scintillation data spanning seven years from Ascension Island, U.K.; Ancon, Peru; and Antofagasta, Chile in the Atlantic/Americas longitudinal sector at as well as data from Parepare, Indonesia; Marak Parak, Malaysia; Pontianak, Indonesia; Guam; and Diego Garcia, U.K.; in the Pacific longitudinal sector. From these data, we calculate percent probability of occurrence of scintillation at various intensities described by the S4 index. Additionally, we determine Dilution of Precision at one minute resolution. We examine diurnal, seasonal and solar cycle characteristics and make spatial comparisons. In general, activity was greatest during the equinoxes and solar maximum, although scintillation at Antofagasta, Chile was higher during 1998 rather than at solar maximum.

  14. Lithium indium diselenide: A new scintillator for neutron imaging

    NASA Astrophysics Data System (ADS)

    Lukosi, Eric; Herrera, Elan; Hamm, Daniel; Lee, Kyung-Min; Wiggins, Brenden; Trtik, Pavel; Penumadu, Dayakar; Young, Stephen; Santodonato, Louis; Bilheux, Hassina; Burger, Arnold; Matei, Liviu; Stowe, Ashley C.

    2016-09-01

    Lithium indium diselenide, 6LiInSe2 or LISe, is a newly developed neutron detection material that shows both semiconducting and scintillating properties. This paper reports on the performance of scintillating LISe crystals for its potential use as a converter screen for cold neutron imaging. The spatial resolution of LISe, determined using a 10% threshold of the Modulation Transfer Function (MTF), was found to not scale linearly with thickness. Crystals having a thickness of 450 μm or larger resulted in an average spatial resolution of 67 μm, and the thinner crystals exhibited an increase in spatial resolution down to the Nyquist frequency of the CCD. The highest measured spatial resolution of 198 μm thick LISe (27 μm) outperforms a commercial 50 μm thick ZnS(Cu):6LiF scintillation screen by more than a factor of three. For the LISe dimensions considered in this study, it was found that the light yield of LISe did not scale with its thickness. However, absorption measurements indicate that the 6Li concentration is uniform and the neutron absorption efficiency of LISe as a function of thickness follows general nuclear theory. This suggests that the differences in apparent brightness observed for the LISe samples investigated may be due to a combination of secondary charged particle escape, scintillation light transport in the bulk and across the LISe-air interface, and variations in the activation of the scintillation mechanism. Finally, it was found that the presence of 115In and its long-lived 116In activation product did not result in ghosting (memory of past neutron exposure), demonstrating potential of LISe for imaging transient systems.

  15. Extruded plastic scintillator including inorganic powders

    DOEpatents

    Bross, Alan D.; Mellott, Kerry L.; Pla-Dalmau, Anna

    2006-06-27

    A method for producing a plastic scintillator is disclosed. A plurality of nano-sized particles and one or more dopants can be combined with a plastic material for the formation of a plastic scintillator thereof. The nano-sized particles, the dopant and the plastic material can be combined within the dry inert atmosphere of an extruder to produce a reaction that results in the formation of a plastic scintillator thereof and the deposition of energy within the plastic scintillator, such that the plastic scintillator produces light signifying the detection of a radiative element. The nano-sized particles can be treated with an inert gas prior to processing the nano-sized particles, the dopant and the plastic material utilizing the extruder. The plastic scintillator can be a neutron-sensitive scintillator, x-ray sensitive scintillator and/or a scintillator for the detection of minimum ionizing particles.

  16. PMT calibration of a scintillation detector using primary scintillation

    NASA Astrophysics Data System (ADS)

    Freitas, E. D. C.; Fernandes, L. M. P.; Yahlali, N.; Pérez, J.; Álvarez, V.; Borges, F. I. G.; Camargo, M.; Cárcel, S.; Cebrián, S.; Cervera, A.; Conde, C. A. N.; Dafni, T.; Díaz, J.; Esteve, R.; Ferrario, P.; Ferreira, A. L.; Gehman, V. M.; Goldschmidt, A.; Gómez, H.; Gómez-Cadenas, J. J.; González Díaz, D.; Gutiérrez, R. M.; Hauptman, J.; Hernando Morata, J. A.; Herrera, D. C.; Irastorza, I. G.; Labarga, L.; Laing, A.; Liubarsky, I.; Lopez-March, N.; Lorca, D.; Losada, M.; Luzón, G.; Marí, A.; Martín-Albo, J.; Martínez, A.; Martínez Lema, G.; Miller, T.; Monrabal, F.; Monserrate, M.; Mora, F. J.; Moutinho, L. M.; Muñoz Vidal, J.; Nebot Guinot, M.; Nygren, D.; Oliveira, C. A. B.; Pérez, J.; Pérez Aparicio, J. L.; Querol, M.; Renner, J.; Ripoll, L.; Rodríguez, A.; Rodríguez, J.; Santos, F. P.; Dos Santos, J. M. F.; Seguí, L.; Serra, L.; Shuman, D.; Simón, A.; Sofka, C.; Sorel, M.; Toledo, J. F.; Torrent, J.; Tsamalaidze, Z.; Veloso, J. F. C. A.; Villar, J. A.; Webb, R.; White, J.; Monteiro, C. M. B.

    2015-02-01

    We have studied the calibration of PMTs in scintillation detectors, inducing single electron response on the PMT from primary scintillation produced by x-ray interaction. The results agree with those obtained by the commonly used single electron response (SER) method, which uses LED light pulses to induce the PMT SER. The use of the primary scintillation for PMT calibration will be convenient in situations where the PMT is already in situ, when it becomes difficult or even impossible to apply the SER method, e.g. in commercial sealed scintillator/PMT devices. Furthermore, we have experimentally investigated the possibility of fitting the high-charge tail of the PMT SER pulse-height distribution to an exponential function, inferring the PMT gain from the inverse of the exponent. The results of the exponential fit method agree with those obtained by the SER method for pulse-height distributions resulting from an average number of around 1.0 photoelectrons reaching the first dynode per light/scintillation pulse. The SER method has higher precision and, therefore, is used in a larger number of applications. Nevertheless, the exponential fit method will be useful in situations where the single photoelectron peak is under the background or noise peak and it may present an alternative, simple way, for relative gain calibration of PMT arrays as well as for monitoring the PMT gain variations.

  17. AMIGA at the Auger Observatory: the scintillator module testing system

    NASA Astrophysics Data System (ADS)

    Platino, M.; Hampel, M. R.; Almela, A.; Krieger, A.; Gorbeña, D.; Ferrero, A.; De La Vega, G.; Lucero, A.; Suarez, F.; Videla, M.; Wainberg, O.; Etchegoyen, A.

    2011-06-01

    AMIGA is an extension of the Pierre Auger Observatory that will consist of 85 detector pairs each one composed of a surface water-Cherenkov detector and a buried muon counter. Each muon counter has an area of 30 m2 and is made of scintillator strips with doped optical fibers glued to them, which guide the light to 64 pixels photomultiplier tubes. The detector pairs are arranged at 433 m and 750 m array spacings. In this paper we present the testing and initial calibration system for the scintillator modules that constitute each muon counter of AMIGA. The scintillator modules are tested with a "scanner" that consists of an x-y positioning system that moves a 5 mCi 137Cs radioactive source over the module taking data at fixed locations. The scanner both tests the module for possible fabrication defects and stores the light-attenuation curve parameters. A complete scanning process of a 64 strip scintillator module has been performed and results are presented. Also, attenuation curves obtained with scanner and with background muons are compared with satisfactory results.

  18. Scintillation Arcs: Probing Turbulence and Structure in the ISM

    NASA Astrophysics Data System (ADS)

    Stinebring, Daniel R.

    2006-12-01

    Multi-path scattering through inhomogeneities in the interstellar medium causes many related effects. In this review, I concentrate on the phenomenon of scintillation arcs, which are parabolic patterns in the secondary spectrum caused by interference between different angular components of the scatter-broadened image of a pulsar. Scintillation arcs are now fairly well understood. The measured curvature of the arc, together with proper motion and distance information about the pulsar, can be used to determine the location of thin scattering screens along the line of sight to the object. Some recent work of this type is presented. The puzzle of substructure in the power distribution of scintillation arcs is poorly understood, however, and is commented on as an open puzzle. In particular, some inferred physical structures in the ISM are small scale (˜ 1 AU) and over-dense with respect to the background medium. Finally, an application of scintillation arc studies to the correction of high-precision pulsar timing is presented.

  19. FNAL-NICADD extruded scintillator

    SciTech Connect

    Beznosko, D.; Bross, A.; Dyshkant, A.; Pla-Dalmau, A.; Rykalin, V.; /Northern Illinois U.

    2005-09-01

    The possibility to produce a scintillator that satisfies the demands of physicists from different science areas has emerged with the installation of an extrusion line at Fermi National Accelerator Laboratory (FNAL). The extruder is the product of the fruitful collaboration between FNAL and Northern Illinois Center for Accelerator and Detector Development (NICADD) at Northern Illinois University (NIU). The results from the light output, light attenuation length and mechanical tolerance indicate that FNAL-NICADD scintillator is of high quality. Improvements in the extrusion die will yield better scintillator profiles and decrease the time needed for initial tuning. This paper will present the characteristics of the FNAL-NICADD scintillator based on the measurements performed. They include the response to MIPs from cosmic rays for individual extruded strips and irradiation studies where extruded samples were irradiated up to 1 Mrad. We will also discuss the results achieved with a new die design. The attractive perspective of using the extruded scintillator with MRS (Metal Resistive Semiconductor) photodetector readout will also be shown.

  20. New scintillation materials and scintiblocs for neutron and γ-rays registration

    NASA Astrophysics Data System (ADS)

    Koroleva, T. S.; Shulgin, B. V.; Pedrini, Ch.; Ivanov, V. Yu.; Raikov, D. V.; Tcherepanov, A. N.

    2005-01-01

    This paper is a short review of some new scintillation materials, scintillation detectors and scintillation systems for registration of gamma-rays, X-rays, neutrons and neutrinos, which have been developed on the level of inventions and a new fundamental level in the Ural State Technical University-UPI (Ekaterinburg, Russia) and Laboratoire de Physico-Chimie des Matériaux Luminescents (Université Lyon 1, France). The part of Russian patents for this area are presented: some most important new scintillation materials (on the base of lithium hydride, silicate compounds, compounds on the base of aluminates, compounds on the base of fluorides and oxyfluorides, compounds on the base of oxides and oxides crystals, glasses and transparent ceramics) and new scintillation devices (on the base of HgI2, on the base of LiKSO4, sandwich-detectors (organic-inorganic-glass-fiber materials), combine detectors, detectors with photodiodes registration and spectrum shifter, surface scintillation structures and screens, and fiber scintillation devices).

  1. Structural design of a high energy particle detector using liquid scintillator

    SciTech Connect

    Berg, Timothy John; /Minnesota U.

    1997-02-01

    This thesis presents a design for a 10,000 ton liquid scintillator neutrino detector being considered for the MINOS project at Fermilab. Details of designing, manufacturing, and assembling the active detector components are presented. The detector consists of 1080 magnetized steel absorber planes alternating with 1080 active detector planes. Each active plane is made up of plastic extrusions divided into nearly 400 cells for positional resolution. Life tests on the plastic extrusions determine their feasibility for containing the scintillator. The extrusions are sealed at the bottom, filled with liquid scintillator, and have an optical fiber running the entire length of each cell. The fibers terminate at the top of each extrusion in a manifold. An optical-fiber-light-guide connects the fibers in each manifold to a photo-detector. The photo-detector converts the light signals from the scintillator and optical fibers into electrical impulses for computer analysis.

  2. Radiopure Metal-Loaded Liquid Scintillator

    SciTech Connect

    Rosero, Richard; Yeh, Minfang

    2015-03-18

    Metal-loaded liquid scintillator plays a key role in particle and nuclear physics experiments. The applications of metal ions in various neutrino experiments and the purification methods for different scintillator components are discussed in this paper.

  3. Radiopure metal-loaded liquid scintillator

    SciTech Connect

    Rosero, Richard; Yeh, Minfang

    2015-08-17

    Metal-loaded liquid scintillator plays a key role in particle and nuclear physics experiments. The applications of metal ions in various neutrino experiments and the purification methods for different scintillator components are discussed in this paper.

  4. Unitary scintillation detector and system

    DOEpatents

    McElhaney, Stephanie A.; Chiles, Marion M.

    1994-01-01

    The invention is a unitary alpha, beta, and gamma scintillation detector and system for sensing the presence of alpha, beta, and gamma radiations selectively or simultaneously. The scintillators are mounted in a light-tight housing provided with an entrance window for admitting alpha, beta, and gamma radiation and excluding ambient light from the housing. Light pulses from each scintillator have different decay constants that are converted by a photosensitive device into corresponding differently shaped electrical pulses. A pulse discrimination system identifies the electrical pulses by their respective pulse shapes which are determined by decay time. The identified electrical pulses are counted in separate channel analyzers to indicate the respective levels of sensed alpha, beta, and gamma radiations.

  5. Unitary scintillation detector and system

    DOEpatents

    McElhaney, S.A.; Chiles, M.M.

    1994-05-31

    The invention is a unitary alpha, beta, and gamma scintillation detector and system for sensing the presence of alpha, beta, and gamma radiations selectively or simultaneously. The scintillators are mounted in a light-tight housing provided with an entrance window for admitting alpha, beta, and gamma radiation and excluding ambient light from the housing. Light pulses from each scintillator have different decay constants that are converted by a photosensitive device into corresponding differently shaped electrical pulses. A pulse discrimination system identifies the electrical pulses by their respective pulse shapes which are determined by decay time. The identified electrical pulses are counted in separate channel analyzers to indicate the respective levels of sensed alpha, beta, and gamma radiations. 10 figs.

  6. Fracture-resistant lanthanide scintillators

    DOEpatents

    Doty, F. Patrick

    2011-01-04

    Lanthanide halide alloys have recently enabled scintillating gamma ray spectrometers comparable to room temperature semiconductors (<3% FWHM energy resolutions at 662 keV). However brittle fracture of these materials upon cooling hinders the growth of large volume crystals. Efforts to improve the strength through non-lanthanide alloy substitution, while preserving scintillation, have been demonstrated. Isovalent alloys having nominal compositions of comprising Al, Ga, Sc, Y, and In dopants as well as aliovalent alloys comprising Ca, Sr, Zr, Hf, Zn, and Pb dopants were prepared. All of these alloys exhibit bright fluorescence under UV excitation, with varying shifts in the spectral peaks and intensities relative to pure CeBr.sub.3. Further, these alloys scintillate when coupled to a photomultiplier tube (PMT) and exposed to .sup.137Cs gamma rays.

  7. Scintillation-Hardened GPS Receiver

    NASA Technical Reports Server (NTRS)

    Stephens, Donald R.

    2015-01-01

    CommLargo, Inc., has developed a scintillation-hardened Global Positioning System (GPS) receiver that improves reliability for low-orbit missions and complies with NASA's Space Telecommunications Radio System (STRS) architecture standards. A software-defined radio (SDR) implementation allows a single hardware element to function as either a conventional radio or as a GPS receiver, providing backup and redundancy for platforms such as the International Space Station (ISS) and high-value remote sensing platforms. The innovation's flexible SDR implementation reduces cost, weight, and power requirements. Scintillation hardening improves mission reliability and variability. In Phase I, CommLargo refactored an open-source GPS software package with Kalman filter-based tracking loops to improve performance during scintillation and also demonstrated improved navigation during a geomagnetic storm. In Phase II, the company generated a new field-programmable gate array (FPGA)-based GPS waveform to demonstrate on NASA's Space Communication and Navigation (SCaN) test bed.

  8. Development of radiation hard scintillators

    SciTech Connect

    Markley, F.; Woods, D.; Pla-Dalmau, A.; Foster, G. ); Blackburn, R. )

    1992-05-01

    Substantial improvements have been made in the radiation hardness of plastic scintillators. Cylinders of scintillating materials 2.2 cm in diameter and 1 cm thick have been exposed to 10 Mrads of gamma rays at a dose rate of 1 Mrad/h in a nitrogen atmosphere. One of the formulations tested showed an immediate decrease in pulse height of only 4% and has remained stable for 12 days while annealing in air. By comparison a commercial PVT scintillator showed an immediate decrease of 58% and after 43 days of annealing in air it improved to a 14% loss. The formulated sample consisted of 70 parts by weight of Dow polystyrene, 30 pbw of pentaphenyltrimethyltrisiloxane (Dow Corning DC 705 oil), 2 pbw of p-terphenyl, 0.2 pbw of tetraphenylbutadiene, and 0.5 pbw of UVASIL299LM from Ferro.

  9. Response of liquid scintillator assemblies as a function of angular orientation

    NASA Astrophysics Data System (ADS)

    Naeem, S. F.; Scarpelli, M.; Miller, E.; Clarke, S. D.; Pozzi, S. A.

    2014-06-01

    Liquid scintillator detector assemblies contain an inert nitrogen expansion volume to allow for expansion of the liquid with changing temperature. Measurements and Geant4 Monte Carlo simulations are performed to study the dependence of pulse height distribution shapes as a function of detector angle for two liquid scintillators assemblies filled with 97% organic-liquid cocktail and a 3% expansion volume. A 12.7-cm diameter by 12.7-cm long and a 7.6-cm diameter by 9.1-cm long EJ-309 liquid scintillator assemblies are investigated using a 137Cs gamma-ray source. Aside from the differences in dimensions, the detector assemblies also differed in the design of the active detector volume: there is no light guide in the 12.7-cm-diameter detector assembly, whereas the 7.6-cm-diameter detector contains a BK7 light guide between the scintillation liquid and optical coupling to the photomultiplier tube. Results for the 12.7-cm-diameter detector show a decrease in the position of the Compton edge ranges from 4% to 40% at detector orientations where the expansion volume exists between scintillating medium and the photomultiplier tube. Results for the 7.6-cm-diameter detector show that the position of the Compton edge is relatively unaffected at all detector orientations due to the presence of light guide.

  10. An imaging technique for detection and absolute calibration of scintillation light

    SciTech Connect

    Pappalardo, Alfio; Cosentino, Luigi; Finocchiaro, Paolo

    2010-03-15

    Triggered by the need of a detection system to be used in experiments of nuclear fusion in laser-generated plasmas, we developed an imaging technique for the measurement and calibration of the scintillation light yield of scintillating materials. As in such experiments, all the reaction products are generated in an ultrashort time frame, the event-by-event data acquisition scheme is not feasible. As an alternative to the emulsion technique (or the equivalent CR39 sheets) we propose a scintillating screen readout by means of a high performance charge coupled device camera. Even though it is not strictly required in the particular application, this technique allows the absolute calibration of the scintillation light yield.

  11. Comprehensive renal scintillation procedures in spinal cord injury: comparison with excretory urography

    SciTech Connect

    Lloyd, L.K.; Dubovsky, E.V.; Bueschen, A.J.; Witten, D.M.; Scott, J.W.; Kuhlemeier, K.; Stover, S.L.

    1981-07-01

    A /sup 131/iodine orthoiodohippurate comprehensive renal scintillation procedure was performed and compared to results of excretory urography in 200 spinal cord injury patients. No severe urographic abnormalities were undetected by the comprehensive renal scintillation procedure. Only 1.4 per cent of renal units had greater than minimal pyelocaliectasis or ureterectasis in the presence of a normal radionuclide examination. A relatively large number of abnormalities were detected on the renal scintillation procedure when the excretory urogram was normal. Serial followup will be required to determine the significance of these findings but present data suggest that a comprehensive renal scintillation procedure and a plain film of the kidneys, ureters and bladder may be used for screening upper urinary tract abnormalities in lieu of an excretory urogram. This is particularly advantageous for the spinal cord injury population, since there have been no toxic or allergic reactions reported, no bowel preparation or dehydration is required and there is relatively low radiation exposure.

  12. Nanophosphor composite scintillator with a liquid matrix

    DOEpatents

    McKigney, Edward Allen; Burrell, Anthony Keiran; Bennett, Bryan L.; Cooke, David Wayne; Ott, Kevin Curtis; Bacrania, Minesh Kantilal; Del Sesto, Rico Emilio; Gilbertson, Robert David; Muenchausen, Ross Edward; McCleskey, Thomas Mark

    2010-03-16

    An improved nanophosphor scintillator liquid comprises nanophosphor particles in a liquid matrix. The nanophosphor particles are optionally surface modified with an organic ligand. The surface modified nanophosphor particle is essentially surface charge neutral, thereby preventing agglomeration of the nanophosphor particles during dispersion in a liquid scintillator matrix. The improved nanophosphor scintillator liquid may be used in any conventional liquid scintillator application, including in a radiation detector.

  13. Magnetic fields and scintillator performance

    SciTech Connect

    Green, D.; Ronzhin, A.; Hagopian, V.

    1995-06-01

    Experimental data have shown that the light output of a scintillator depends on the magnitude of the externally applied magnetic fields, and that this variation can affect the calorimeter calibration and possibly resolution. The goal of the measurements presented here is to study the light yield of scintillators in high magnetic fields in conditions that are similar to those anticipated for the LHC CMS detector. Two independent measurements were performed, the first at Fermilab and the second at the National High Magnetic Field Laboratory at Florida State University.

  14. Liquid scintillating fiber calorimetry prototype

    SciTech Connect

    Gui, M.; Brookes, D.; David, A.

    1995-08-01

    A full size liquid scintillating fiber spaghetti-hadronic calorimeter has been constructed and tested using cosmic rays at Texas A and M University. The purpose of this research is to find practical solutions for detectors to be used in extremely high radiation environments. The details of design and construction of this module are presented. The advantages of using liquid scintillating materials were investigated. Relevant subjects are addressed. Cosmic ray test results are compared with that of GEANT Monte Carlo simulations. Over all, they agree well with each other. The conclusion is that calorimeters utilizing this technique can be used in high radiation environments such as SSC colliding area.

  15. Hygroscopicity Evaluation of Halide Scintillators

    SciTech Connect

    Zhuravleva, M; Stand, L; Wei, H; Hobbs, C. L.; Boatner, Lynn A; Ramey, Joanne Oxendine; Burger, Arnold; Rowe, E; Bhattacharya, P.; Tupitsyn, E; Melcher, Charles L

    2014-01-01

    A collaborative study of relative hygroscopicity of anhydrous halide scintillators grown at various laboratories is presented. We have developed a technique to evaluate moisture sensitivity of both raw materials and grown crystals, in which the moisture absorption rate is measured using a gravimetric analysis. Degradation of the scintillation performance was investigated by recording gamma-ray spectra and monitoring the photopeak position, count rate and energy resolution. The accompanying physical degradation of the samples exposed to ambient atmosphere was photographically recorded as well. The results were compared with ben

  16. Photonic crystal scintillators and methods of manufacture

    SciTech Connect

    Torres, Ricardo D.; Sexton, Lindsay T.; Fuentes, Roderick E.; Cortes-Concepcion, Jose

    2015-08-11

    Photonic crystal scintillators and their methods of manufacture are provided. Exemplary methods of manufacture include using a highly-ordered porous anodic alumina membrane as a pattern transfer mask for either the etching of underlying material or for the deposition of additional material onto the surface of a scintillator. Exemplary detectors utilizing such photonic crystal scintillators are also provided.

  17. Composite scintillators for detection of ionizing radiation

    DOEpatents

    Dai, Sheng [Knoxville, TN; Stephan, Andrew Curtis [Knoxville, TN; Brown, Suree S [Knoxville, TN; Wallace, Steven A [Knoxville, TN; Rondinone, Adam J [Knoxville, TN

    2010-12-28

    Applicant's present invention is a composite scintillator having enhanced transparency for detecting ionizing radiation comprising a material having optical transparency wherein said material comprises nano-sized objects having a size in at least one dimension that is less than the wavelength of light emitted by the composite scintillator wherein the composite scintillator is designed to have selected properties suitable for a particular application.

  18. Characteristics of High Latitude Ionosphere Scintillations

    NASA Astrophysics Data System (ADS)

    Morton, Y.

    2012-12-01

    As we enter a new solar maximum period, global navigation satellite systems (GNSS) receivers, especially the ones operating in high latitude and equatorial regions, are facing an increasing threat from ionosphere scintillations. The increased solar activities, however, also offer a great opportunity to collect scintillation data to characterize scintillation signal parameters and ionosphere irregularities. While there are numerous GPS receivers deployed around the globe to monitor ionosphere scintillations, most of them are commercial receivers whose signal processing mechanisms are not designed to operate under ionosphere scintillation. As a result, they may distort scintillation signal parameters or lose lock of satellite signals under strong scintillations. Since 2008, we have established and continuously improved a unique GNSS receiver array at HAARP, Alaska. The array contains high ends commercial receivers and custom RF front ends which can be automatically triggered to collect high quality GPS and GLONASS satellite signals during controlled heating experiments and natural scintillation events. Custom designed receiver signal tracking algorithms aim to preserve true scintillation signatures are used to process the raw RF samples. Signal strength, carrier phase, and relative TEC measurements generated by the receiver array since its inception have been analyzed to characterize high latitude scintillation phenomena. Daily, seasonal, and solar events dependency of scintillation occurrence, spectral contents of scintillation activities, and plasma drifts derived from these measurements will be presented. These interesting results demonstrate the feasibility and effectiveness of our experimental data collection system in providing insightful details of ionosphere responses to active perturbations and natural disturbances.

  19. Low-Dose Megavoltage Cone-Beam CT imaging using Thick, Segmented Scintillators

    PubMed Central

    El-Mohri, Youcef; Antonuk, Larry E.; Zhao, Qihua; Choroszucha, Richard B.; Jiang, Hao; Liu, Langechuan

    2011-01-01

    Megavoltage, cone-beam computed tomography (MV CBCT) employing an electronic portal imaging device (EPID) is a highly promising technique for providing soft-tissue visualization in image-guided radiotherapy. However, current EPIDs based on active matrix flat-panel imagers (AMFPIs), which are regarded as the gold standard for portal imaging and referred to as conventional MV AMFPIs, require high radiation doses to achieve this goal due to poor x-ray detection efficiency (~2% at 6 MV). To overcome this limitation, the incorporation of thick, segmented, crystalline scintillators, as a replacement for the phosphor screens used in these AMFPIs, has been shown to significantly improve the DQE performance, leading to improved image quality for projection imaging at low dose. Toward the realization of practical AMFPIs capable of low dose, soft-tissue visualization using MV CBCT imaging, two prototype AMFPIs incorporating segmented scintillators with ~11 mm thick CsI:Tl and BGO crystals were evaluated. Each scintillator consists of 120 × 60 crystalline elements separated by reflective septal walls, with an element-to-element pitch of 1.016 mm. The prototypes were evaluated using a bench-top CBCT system, allowing the acquisition of 180 projection, 360° tomographic scans with a 6 MV radiotherapy photon beam. Reconstructed images of a spatial resolution phantom, as well as of a water-equivalent phantom, embedded with tissue equivalent objects having electron densities (relative to water) varying from ~0.28 to ~1.70, were obtained down to one beam pulse per projection image, corresponding to a scan dose of ~4 cGy – a dose similar to that required for a single portal image obtained from a conventional MV AMFPI. By virtue of their significantly improved DQE, the prototypes provided low contrast visualization, allowing clear delineation of an object with an electron density difference of ~2.76%. Results of contrast, noise and contrast-to-noise ratio are presented as a function

  20. Low-dose megavoltage cone-beam CT imaging using thick, segmented scintillators

    NASA Astrophysics Data System (ADS)

    El-Mohri, Youcef; Antonuk, Larry E.; Zhao, Qihua; Choroszucha, Richard B.; Jiang, Hao; Liu, Langechuan

    2011-03-01

    Megavoltage, cone-beam computed tomography (MV CBCT) employing an electronic portal imaging device (EPID) is a highly promising technique for providing soft-tissue visualization in image-guided radiotherapy. However, current EPIDs based on active matrix flat-panel imagers (AMFPIs), which are regarded as the gold standard for portal imaging and referred to as conventional MV AMFPIs, require high radiation doses to achieve this goal due to poor x-ray detection efficiency (~2% at 6 MV). To overcome this limitation, the incorporation of thick, segmented, crystalline scintillators, as a replacement for the phosphor screens used in these AMFPIs, has been shown to significantly improve the detective quantum efficiency (DQE) performance, leading to improved image quality for projection imaging at low dose. Toward the realization of practical AMFPIs capable of low dose, soft-tissue visualization using MV CBCT imaging, two prototype AMFPIs incorporating segmented scintillators with ~11 mm thick CsI:Tl and Bi4Ge3O12 (BGO) crystals were evaluated. Each scintillator consists of 120 × 60 crystalline elements separated by reflective septal walls, with an element-to-element pitch of 1.016 mm. The prototypes were evaluated using a bench-top CBCT system, allowing the acquisition of 180 projection, 360° tomographic scans with a 6 MV radiotherapy photon beam. Reconstructed images of a spatial resolution phantom, as well as of a water-equivalent phantom, embedded with tissue equivalent objects having electron densities (relative to water) varying from ~0.28 to ~1.70, were obtained down to one beam pulse per projection image, corresponding to a scan dose of ~4 cGy--a dose similar to that required for a single portal image obtained from a conventional MV AMFPI. By virtue of their significantly improved DQE, the prototypes provided low contrast visualization, allowing clear delineation of an object with an electron density difference of ~2.76%. Results of contrast, noise and contrast

  1. Synthesis of plastic scintillation microspheres: Evaluation of scintillators

    NASA Astrophysics Data System (ADS)

    Santiago, L. M.; Bagán, H.; Tarancón, A.; Garcia, J. F.

    2013-01-01

    The use of plastic scintillation microspheres (PSm) appear to be an alternative to liquid scintillation for the quantification of alpha and beta emitters because it does not generate mixed wastes after the measurement (organic and radioactive). In addition to routine radionuclide determinations, PSm can be used for further applications, e.g. for usage in a continuous monitoring equipment, for measurements of samples with a high salt concentration and for an extractive scintillation support which permits the separation, pre-concentration and measurement of the radionuclides without additional steps of elution and sample preparation. However, only a few manufacturers provide PSm, and the low number of regular suppliers reduces its availability and restricts the compositions and sizes available. In this article, a synthesis method based on the extraction/evaporation methodology has been developed and successfully used for the synthesis of plastic scintillation microspheres. Seven different compositions of plastic scintillation microspheres have been synthesised; PSm1 with polystyrene, PSm2 with 2,5-Diphenyloxazol(PPO), PSm3 with p-terphenyl (pT), PSm4 with PPO and 1,4-bis(5-phenyloxazol-2-yl) (POPOP), PSm5 pT and (1,4-bis [2-methylstyryl] benzene) (Bis-MSB), PSm6 with PPO, POPOP and naphthalene and PSm7 with pT, Bis-MSB and naphthalene. The synthesised plastic scintillation microspheres have been characterised in terms of their morphology, detection capabilities and alpha/beta separation capacity. The microspheres had a median diameter of approximately 130 μm. Maximum detection efficiency values were obtained for the PSm4 composition as follows 1.18% for 3H, 51.2% for 14C, 180.6% for 90Sr/90Y and 76.7% for 241Am. Values of the SQP(E) parameter were approximately 790 for PSm4 and PSm5. These values show that the synthesised PSm exhibit good scintillation properties and that the spectra are at channel numbers higher than in commercial PSm. Finally, the addition of

  2. Rare earth phosphors and phosphor screens

    DOEpatents

    Buchanan, Robert A.; Maple, T. Grant; Sklensky, Alden F.

    1981-01-01

    This invention relates to rare earth phosphor screens for converting image carrying incident radiation to image carrying visible or near-visible radiation and to the rare earth phosphor materials utilized in such screens. The invention further relates to methods for converting image carrying charged particles to image carrying radiation principally in the blue and near-ultraviolet region of the spectrum and to stabilized rare earth phosphors characterized by having a continuous surface layer of the phosphors of the invention. More particularly, the phosphors of the invention are oxychlorides and oxybromides of yttrium, lanthanum and gadolinium activated with trivalent cerium and the conversion screens are of the type illustratively including x-ray conversion screens, image amplifier tube screens, neutron imaging screens, cathode ray tube screens, high energy gamma ray screens, scintillation detector screens and screens for real-time translation of image carrying high energy radiation to image carrying visible or near-visible radiation.

  3. Review of Ionospheric Scintillation Models and proposing a Novel Model for Characterizing High Latitude Irregularities

    NASA Astrophysics Data System (ADS)

    Deshpande, K.; Bust, G. S.; Clauer, C. R.

    2013-12-01

    The study of ionospheric scintillations of radio signal involves a problem of electromagnetic (EM) wave propagation in random media and has been a subject of interest for more than last 5 decades. Some of the representative works are by Booker et. al (1950), Ratcliffe (1956), Wernik and Liu (1975), Yeh and Liu (1982), Secan et. al (1995), Costa and Basu (2002), Rino and Carrano (2011). Many of the scintillation models employ a phase screen model introduced by Rino (1979). Beniguel and Hamel (2011) implemented a global ionospheric scintillation model for equatorial regions showing a good agreement of the model with measurements. Implementing these models in the study of ionospheric scintillations of radio signals at high latitudes could be challenging since the path of satellite signal to ground has a variable angle of incidence, in addition to the complicated geometry of magnetic field lines at high latitude and polar regions, and complex magnetosphere-ionosphere coupling mechanisms creating the irregularities. We have developed a high fidelity 3-dimensional Global Positioning System Ionospheric Scintillation Model (3D-GPSISM) which is a full 3D EM wave propagation model to simulate GPS scintillations in high latitude ionosphere. The results from this model can form a basic framework on the use of inverse method to understand the physics of high latitude irregularities using GPS scintillations. We are using our model and an inverse method for selected scintillation observations during 2010 - 2013 from GPS receivers at South Pole, McMurdo and remote stations on Antarctica in conjunction with ancillary observations from SuperDARN, magnetometers, All Sky Imagers etc. We believe that such inverse method can be used to derive certain characteristics of the irregularity causing the scintillations and further achieve an improved understanding of the physics of high latitude irregularities.

  4. SNO+ Scintillator Purification and Assay

    SciTech Connect

    Ford, R.; Vazquez-Jauregui, E.; Chen, M.; Chkvorets, O.; Hallman, D.

    2011-04-27

    We describe the R and D on the scintillator purification and assay methods and technology for the SNO+ neutrino and double-beta decay experiment. The SNO+ experiment is a replacement of the SNO heavy water with liquid scintillator comprised of 2 g/L PPO in linear alkylbenzene (LAB). During filling the LAB will be transported underground by rail car and purified by multi-stage distillation and steam stripping at a flow rate of 19 LPM. While the detector is operational the scintillator can be recirculated at 150 LPM (full detector volume in 4 days) to provide repurification as necessary by either water extraction (for Ra, K, Bi) or by functional metal scavenger columns (for Pb, Ra, Bi, Ac, Th) followed by steam stripping to remove noble gases and oxygen (Rn, O{sub 2}, Kr, Ar). The metal scavenger columns also provide a method for scintillator assay for ex-situ measurement of the U and Th chain radioactivity. We have developed ''natural'' radioactive spikes of Pb and Ra in LAB and use these for purification testing. Lastly, we present the planned operating modes and purification strategies and the plant specifications and design.

  5. Boron Doped Plastic Scintillator Efficiency

    NASA Astrophysics Data System (ADS)

    Mahl, Adam; Chouinard-Dussault, Pascale; Pecinovsky, Cory; Potter, Andrew; Remedes, Tyler; Dorgan, John; Greife, Uwe

    2013-04-01

    This talk will describe the progress made in an interdisciplinary development project aimed at cost-effective, neutron sensitive, plastic scintillator. Colorado School of Mines researchers with backgrounds in Physics, Chemistry, and Chemical Engineering have worked on the incorporation of ^10B in plastics through extrusion. First results on transparent samples using fluorescent spectroscopy and beta excitation will be presented.

  6. SNO+ Scintillator Purification and Assay

    NASA Astrophysics Data System (ADS)

    Ford, R.; Chen, M.; Chkvorets, O.; Hallman, D.; Vázquez-Jáuregui, E.

    2011-04-01

    We describe the R&D on the scintillator purification and assay methods and technology for the SNO+ neutrino and double-beta decay experiment. The SNO+ experiment is a replacement of the SNO heavy water with liquid scintillator comprised of 2 g/L PPO in linear alkylbenzene (LAB). During filling the LAB will be transported underground by rail car and purified by multi-stage distillation and steam stripping at a flow rate of 19 LPM. While the detector is operational the scintillator can be recirculated at 150 LPM (full detector volume in 4 days) to provide repurification as necessary by either water extraction (for Ra, K, Bi) or by functional metal scavenger columns (for Pb, Ra, Bi, Ac, Th) followed by steam stripping to remove noble gases and oxygen (Rn, O2, Kr, Ar). The metal scavenger columns also provide a method for scintillator assay for ex-situ measurement of the U and Th chain radioactivity. We have developed "natural" radioactive spikes of Pb and Ra in LAB and use these for purification testing. Lastly, we present the planned operating modes and purification strategies and the plant specifications and design.

  7. Scintillating fiber ribbon --- tungsten calorimeter

    SciTech Connect

    Bross, A.; Crisler, M.; Kross, B.; Wrbanek, J.

    1989-07-14

    We describe an ultra-high density scintillating fiber and tungsten calorimeter used as an active beam-dump for electrons. Data showing the calorimeter response to electrons with momenta between 50 and 350 GeV/c are presented. 9 figs.

  8. Two dimensional and linear scintillation detectors for fast neutron imaging — comparative analysis

    NASA Astrophysics Data System (ADS)

    Mikerov, V. I.; Koshelev, A. P.; Ozerov, O. V.; Sviridov, A. S.; Yurkov, D. I.

    2014-05-01

    The paper was aimed to compare performance capabilities of two types of scintillation detectors commonly used for fast neutron imaging: two dimensional and linear ones. Best-case values of quantum efficiency, spatial resolution and capacity were estimated for detectors with plastic converter-screen in case of 14 MeV neutrons. For that there were examined nuclear reactions produced in converter-screen by fast neutrons, spatial distributions of energy release of emerged charged particles and amplitude distributions of scintillations generated by these particles. The paper shows that the efficiency of the linear detector is essentially higher and this detector provides potentially better spatial resolution in comparison with the two dimensional detector. But, the two dimensional detector surpasses the linear one in capacity. The presented results can be used for designing radiographic fast neutron detectors with organic scintillators.

  9. Scintillating lustre induced by radial fins.

    PubMed

    Takahashi, Kohske; Fukuda, Haruaki; Watanabe, Katsumi; Ueda, Kazuhiro

    2012-01-01

    Radial lines of Ehrenstein patterns induce illusory scintillating lustre in gray disks inserted into the central gaps (scintillating-lustre effect). We report a novel variant of this illusion by replacing the radial lines with white and black radial fins. Both white and gray disks inserted into the central gaps were perceived as scintillating, if the ratio of the black/white fin width were balanced (ie, close to 1.0). Thus, the grayness of the central disk is not a prerequisite for the scintillation. However, the scintillation was drastically reduced when the ratio was imbalanced. Furthermore, the optimal ratio depended on the color of the center disks. PMID:23145270

  10. Method of making a scintillator waveguide

    DOEpatents

    Bliss, Mary; Craig, Richard A.; Reeder, Paul L.

    2000-01-01

    The present invention is an apparatus for detecting ionizing radiation, having: a waveguide having a first end and a second end, the waveguide formed of a scintillator material wherein the therapeutic ionizing radiation isotropically generates scintillation light signals within the waveguide. This apparatus provides a measure of radiation dose. The apparatus may be modified to permit making a measure of location of radiation dose. Specifically, the scintillation material is segmented into a plurality of segments; and a connecting cable for each of the plurality of segments is used for conducting scintillation signals to a scintillation detector.

  11. Extruded plastic scintillator for MINERvA

    SciTech Connect

    Pla-Dalmau, Anna; Bross, Alan D.; Rykalin, Victor V.; Wood, Brian M.; /NICADD, DeKalb

    2005-11-01

    An extrusion line has recently been installed at Fermilab in collaboration with NICADD (Northern Illinois Center for Accelerator and Detector Development). This new facility will serve to further develop and improve extruded plastic scintillator. Since polystyrene is widely used in the consumer industry, the logical path was to investigate the extrusion of commercial-grade polystyrene pellets with dopants to yield high quality plastic scintillator. The D0 and MINOS experiments are already using extruded scintillator strips in their detectors. A new experiment at Fermilab is pursuing the use of extruded plastic scintillator. A new plastic scintillator strip is being tested and its properties characterized. The initial results are presented here.

  12. Scintillators for positron emission tomography

    SciTech Connect

    Moses, W.W.; Derenzo, S.E.

    1995-09-01

    Like most applications that utilize scintillators for gamma detection, Positron Emission Tomography (PET) desires materials with high light output, short decay time, and excellent stopping power that are also inexpensive, mechanically rugged, and chemically inert. Realizing that this ``ultimate`` scintillator may not exist, this paper evaluates the relative importance of these qualities and describes their impact on the imaging performance of PET. The most important PET scintillator quality is the ability to absorb 511 keV photons in a small volume, which affects the spatial resolution of the camera. The dominant factor is a short attenuation length ({le} 1.5 cm is required), although a high photoelectric fraction is also important (> 30% is desired). The next most important quality is a short decay time, which affects both the dead time and the coincidence timing resolution. Detection rates for single 511 keV photons can be extremely high, so decay times {le} 500 ns are essential to avoid dead time losses. In addition, positron annihilations are identified by time coincidence so {le}5 ns fwhm coincidence pair timing resolution is required to identify events with narrow coincidence windows, reducing contamination due to accidental coincidences. Current trends in PET cameras are toward septaless, ``fully-3D`` cameras, which have significantly higher count rates than conventional 2-D cameras and so place higher demands on scintillator decay time. Light output affects energy resolution, and thus the ability of the camera to identify and reject events where the initial 511 keV photon has undergone Compton scatter in the patient. The scatter to true event fraction is much higher in fully-3D cameras than in 2-D cameras, so future PET cameras would benefit from scintillators with a 511 keV energy resolution < 10--12% fwhm.

  13. [Chemical databases and virtual screening].

    PubMed

    Rognan, Didier; Bonnet, Pascal

    2014-12-01

    A prerequisite to any virtual screening is the definition of compound libraries to be screened. As we describe here, various sources are available. The selection of the proper library is usually project-dependent but at least as important as the screening method itself. This review details the main compound libraries that are available for virtual screening and guide the reader to the best possible selection according to its needs. PMID:25537046

  14. Scintillation Monitoring Using Asymmetry Index

    NASA Astrophysics Data System (ADS)

    Shaikh, Muhammad Mubasshir; Mahrous, Ayman; Abdallah, Amr; Notarpietro, Riccardo

    Variation in electron density can have significant effect on GNSS signals in terms of propagation delay. Ionospheric scintillation can be caused by rapid change of such delay, specifically, when they last for a longer period of time. Ionospheric irregularities that account for scintillation may vary significantly in spatial range and drift with the background plasma at speeds of 45 to 130 m/sec. These patchy irregularities may occur several times during night, e.g. in equatorial region, with the patches move through the ray paths of the GNSS satellite signals. These irregularities are often characterized as either ‘large scale’ (which can be as large as several hundred km in East-West direction and many times that in the North-South direction) or ‘small scale’ (which can be as small as 1m). These small scale irregularities are regarded as the main cause of scintillation [1,2]. In normal solar activity conditions, the mid-latitude ionosphere is not much disturbed. However, during severe magnetic storms, the aurora oval extends towards the equator and the equator anomaly region may stretched towards poles extending the scintillation phenomena more typically associated with those regions into mid-latitudes. In such stormy conditions, the predicted TEC may deviate largely from the true value of the TEC both at low and mid-latitudes due to which GNSS applications may be strongly degraded. This work is an attempt to analyze ionospheric scintillation (S4 index) using ionospheric asymmetry index [3]. The asymmetry index is based on trans-ionospheric propagation between GPS and LEO satellites in a radio occultation (RO) scenario, using background ionospheric data provided by MIDAS [4]. We attempted to simulate one of the recent geomagnetic storms (NOAA scale G4) occurred over low/mid-latitudes. The storm started on 26 September 2011 at UT 18:00 and lasted until early hours of 27 September 2011. The scintillation data for the storm was taken from an ionospheric

  15. LHCb Upgrade: Scintillating Fibre Tracker

    NASA Astrophysics Data System (ADS)

    Tobin, Mark

    2016-07-01

    The LHCb detector will be upgraded during the Long Shutdown 2 (LS2) of the LHC in order to cope with higher instantaneous luminosities and to read out the data at 40 MHz using a trigger-less read-out system. All front-end electronics will be replaced and several sub-detectors must be redesigned to cope with higher occupancy. The current tracking detectors downstream of the LHCb dipole magnet will be replaced by the Scintillating Fibre (SciFi) Tracker. The SciFi Tracker will use scintillating fibres read out by Silicon Photomultipliers (SiPMs). State-of-the-art multi-channel SiPM arrays are being developed to read out the fibres and a custom ASIC will be used to digitise the signals from the SiPMs. The evolution of the design since the Technical Design Report in 2014 and the latest R & D results are presented.

  16. Silicon photomultipliers for scintillating trackers

    NASA Astrophysics Data System (ADS)

    Rabaioli, S.; Berra, A.; Bolognini, D.; Bonvicini, V.; Bosisio, L.; Ciano, S.; Iugovaz, D.; Lietti, D.; Penzo, A.; Prest, M.; Rashevskaya, I.; Reia, S.; Stoppani, L.; Vallazza, E.

    2012-12-01

    In recent years, silicon photomultipliers (SiPMs) have been proposed as a new kind of readout device for scintillating detectors in many experiments. A SiPM consists of a matrix of parallel-connected pixels, which are independent photon counters working in Geiger mode with very high gain (∼106). This contribution presents the use of an array of eight SiPMs (manufactured by FBK-irst) for the readout of a scintillating bar tracker (a small size prototype of the Electron Muon Ranger detector for the MICE experiment). The performances of the SiPMs in terms of signal to noise ratio, efficiency and time resolution will be compared to the ones of a multi-anode photomultiplier tube (MAPMT) connected to the same bars. Both the SiPMs and the MAPMT are interfaced to a VME system through a 64 channel MAROC ASIC.

  17. Radioluminescence dosimetry by scintillating fiber optics: the open challenges

    NASA Astrophysics Data System (ADS)

    Veronese, Ivan; Cantone, Marie Claire; Chiodini, Norberto; De Mattia, Cristina; Fasoli, Mauro; Mones, Eleonora; Vedda, Anna

    2013-09-01

    In the last decade, the interest in scintillating fiber optics for ionizing radiation monitoring is constantly increasing. Among the fields of possible applications of these sensors, radiation therapy represents a driving force for the research and development of new devices. In fact, the small dimensions of fiber optics based detectors, together with their realtime response, make these systems extremely promising both in quality assurance measurements of intensity modulated radiotherapy beams, and in in-vivo dosimetry. On the other hand, two specific aspects might represent limiting factors: (i) the "stem effect", that is the spurious luminescence originating as a consequence of the irradiation of the light guide, and (ii) the "memory effect", that is the radioluminescence sensitivity increase during prolonged exposition to ionizing radiation, typical of many scintillating materials. These two issues, representing the main challenges to face for the effective use of scintillating fiber as dosimeters in radiotherapy, were studied considering amorphous silica matrices prepared by sol-gel method and doped with europium. The origin of the stem effect was investigated by means of spectral measurements of the doped fibers irradiated with Xrays and electrons of different energies, field sizes and orientations. New approaches for removing the stem effect on the basis of the radioluminescent spectral analysis are presented and discussed. Furthermore, the causes and phenomenology of the memory effect are described, considering also the effect of dose accumulation with different dose rates and energies of ionizing radiation.

  18. Detecting scintillations in liquid helium

    NASA Astrophysics Data System (ADS)

    Huffman, P. R.; McKinsey, D. N.

    2013-09-01

    We review our work in developing a tetraphenyl butadiene (TPB)-based detection system for a measurement of the neutron lifetime using magnetically confined ultracold neutrons (UCN). As part of the development of the detection system for this experiment, we studied the scintillation properties of liquid helium itself, characterized the fluorescent efficiencies of different fluors, and built and tested three detector geometries. We provide an overview of the results from these studies as well as references for additional information.

  19. Scintillator diagnostics for the detection of laser accelerated ion beams

    NASA Astrophysics Data System (ADS)

    Cook, N.; Tresca, O.; Lefferts, R.

    2014-09-01

    Laser plasma interaction with ultraintense pulses present exciting schemes for accelerating ions. One of the advantages conferred by using a gaseous laser and target is the potential for a fast (several Hz) repetition rate. This requires diagnostics which are not only suited for a single shot configuration, but also for repeated use. We consider several scintillators as candidates for an imaging diagnostic for protons accelerated to MeV energies by a CO2 laser focused on a gas jet target. We have measured the response of chromium-doped alumina (chromox) and polyvinyl toluene (PVT) screens to protons in the 2-8 MeV range. We have calibrated the luminescent yield in terms of photons emitted per incident proton for each scintillator. We also discuss how light scattering and material properties affect detector resolution. Furthermore, we consider material damage and the presence of an afterglow under intense exposures. Our analysis reveals a near order of magnitude greater yield from chromox in response to proton beams at > 8 MeV energies, while scattering effects favor PVT-based scintillators at lower energies.

  20. Morphology of auroral zone radio wave scintillation

    SciTech Connect

    Rino, C.L.; Matthews, S.J.

    1980-08-01

    This paper describes the morphology of midnight sector and morning sector auroral zone scintillation observations made over a two-year period using the Wideband satelite, which is in a sun-synchronous, low-altitude orbit. No definitive seasonal variation was found. The nighttime data showed the highest scintillation ocurrence levels, but significant amounts of morning scintillation were observed. For the most part the scintillation activity followed the general pattern of local magnetic activity. The most prominent feature in the nightime data is a localized amplitude and phase scintillation enhancement at the point where the propagation vector lies within an L shell. A geometrical effect due to a dynamic slab of sheetlike structures in the F region is hypothesized as the source of his enhancement. The data have been sorted by magnetic activity, proximity to local midnight, and season. The general features of the data are in agreement with the accepted morphology of auroral zone scintillation.

  1. Scintillating Fibre Tracking at High Luminosity Colliders

    NASA Astrophysics Data System (ADS)

    Joram, C.; Haefeli, G.; Leverington, B.

    2015-08-01

    The combination of small diameter scintillating plastic fibres with arrays of SiPM photodetectors has led to a new class of SciFi trackers usable at high luminosity collider experiments. After a short review of the main principles and history of the scintillating fibre technology, we describe the challenges and developments of the large area Scintillating Fibre Tracker currently under development for the upgraded LHCb experiment.

  2. Recording of relativistic particles in thin scintillators

    SciTech Connect

    Tolstukhin, I A.; Somov, Alexander S.; Somov, S. V.; Bolozdynya, A. I.

    2014-11-01

    Results of investigating an assembly of thin scintillators and silicon photomultipliers for registering relativistic particles with the minimum ionization are presented. A high efficiency of registering relativistic particles using an Ej-212 plastic scintillator, BSF-91A wavelength-shifting fiber (Saint-Gobain), and a silicon photomultiplier (Hamamtsu) is shown. The measurement results are used for creating a scintillation hodoscope of the magnetic spectrometer for registering γ quanta in the GlueX experiment.

  3. Spacecraft Radio Scintillation and Solar System Exploration

    NASA Technical Reports Server (NTRS)

    Woo, Richard

    1993-01-01

    When a wave propagates through a turbulent medium, scattering by the random refractive index inhomogeneities can lead to a wide variety of phenomena that have been the subject of extensive study. The observed scattering effects include amplitude or intensity scintillation, phase scintillation, angular broadening, and spectral broadening, among others. In this paper, I will refer to these scattering effects collectively as scintillation. Although the most familiar example is probably the twinkling of stars (light wave intensity scintillation by turbulence in the Earth's atmosphere), scintillation has been encountered and investigated in such diverse fields as ionospheric physics, oceanography, radio astronomy, and radio and optical communications. Ever since planetary spacecraft began exploring the solar system, scintillation has appeared during the propagation of spacecraft radio signals through planetary atmospheres, planetary ionospheres, and the solar wind. Early studies of these phenomena were motivated by the potential adverse effects on communications and navigation, and on experiments that use the radio link to conduct scientific investigations. Examples of the latter are radio occultation measurements (described below) of planetary atmospheres to deduce temperature profiles, and the search for gravitational waves. However,these concerns soon gave way to the emergence of spacecraft radio scintillation as a new scientific tool for exploring small-scale dynamics in planetary atmospheres and structure in the solar wind, complementing in situ and other remote sensing spacecraft measurements, as well as scintillation measurements using natural (celestial) radio sources. The purpose of this paper is to briefly describe and review the solar system spacecraft radio scintillation observations, to summarize the salient features of wave propagation analyses employed in interpreting them, to underscore the unique remote sensing capabilities and scientific relevance of

  4. Waveshifters and Scintillators for Ionizing Radiation Detection

    SciTech Connect

    B.Baumgaugh; J.Bishop; D.Karmgard; J.Marchant; M.McKenna; R.Ruchti; M.Vigneault; L.Hernandez; C.Hurlbut

    2007-12-11

    Scintillation and waveshifter materials have been developed for the detection of ionizing radiation in an STTR program between Ludlum Measurements, Inc. and the University of Notre Dame. Several new waveshifter materials have been developed which are comparable in efficiency and faster in fluorescence decay than the standard material Y11 (K27) used in particle physics for several decades. Additionally, new scintillation materials useful for fiber tracking have been developed which have been compared to 3HF. Lastly, work was done on developing liquid scintillators and paint-on scintillators and waveshifters for high radiation environments.

  5. Divalent fluoride doped cerium fluoride scintillator

    DOEpatents

    Anderson, David F.; Sparrow, Robert W.

    1991-01-01

    The use of divalent fluoride dopants in scintillator materials comprising cerium fluoride is disclosed. The preferred divalent fluoride dopants are calcium fluoride, strontium fluoride, and barium fluoride. The preferred amount of divalent fluoride dopant is less than about two percent by weight of the total scintillator. Cerium fluoride scintillator crystals grown with the addition of a divalent fluoride have exhibited better transmissions and higher light outputs than crystals grown without the addition of such dopants. These scintillators are useful in radiation detection and monitoring applications, and are particularly well suited for high-rate applications such as positron emission tomography (PET).

  6. Radio wave scintillations at equatorial regions

    NASA Technical Reports Server (NTRS)

    Poularikas, A. D.

    1972-01-01

    Radio waves, passing through the atmosphere, experience amplitude and phase fluctuations know as scintillations. A characterization of equatorial scintillation, which has resulted from studies of data recorded primarily in South America and equatorial Africa, is presented. Equatorial scintillation phenomena are complex because they appear to vary with time of day (pre-and postmidnight), season (equinoxes), and magnetic activity. A wider and more systematic geographical coverage is needed for both scientific and engineering purposes; therefore, it is recommended that more observations should be made at earth stations (at low-geomagnetic latitudes) to record equatorial scintillation phenomena.

  7. Evaluation of different scintillators for 1MV NDE x-ray imaging

    NASA Astrophysics Data System (ADS)

    Zentai, George; Ganguly, Arundhuti; Visrshup, Gary

    2014-03-01

    X-ray radiography is an important and frequently used NDE method of testing metal structures, such as tube welding quality, cracks and voids in cast iron or other metals. It gives fast and visible answer for structural defects. The Varian high energy portal imagers on Clinacs used in cancer treatment were tested for this purpose. We compared the traditional Gadox (LANEX) screen with and without a 1mm Cu buildup plate as used clinically. We also tested different hybrid scintillators, which consisted of different phosphor layers deposited onto fiberoptic plates. The last screen tested was a 2cm thick fiberoptic plate which contained scintillating fibers. The sensitivity (ADU = number of digital counts per a given X-ray dose), the resolution (MTF - modulation transfer function) and the DQE (detective quantum efficiency) were compared, with a 1 MV source, for these X-ray conversion screens. We found that the additional 1mm Cu plate, which improves the absorption and the contrast at 6 or higher energy MeV imaging, does not improve the image quality at 1MV. Rather it attenuates the X-rays, resulting in lower sensitivity and a lower DQE(0) of 2.2% with the additional Cu plate compared to DQE(0) of ~4% without the Cu plate. The hybrid scintillators with evaporated phosphors on fiberoptic plates tested were too thin resulting in low sensitivity. The best results were obtained from the thick scintillating fiberoptic screens, which provided the best DQE and high resolution with the 1MV X-ray beam. Further optimization is planned by changing the thickness of the scintillating fiber optic plate.

  8. Interviewing and Selecting Elementary School Teachers and Administrative Personnel. A Guide for the Screening Interview. One of the Better Employment Interviewing Series.

    ERIC Educational Resources Information Center

    Sadetsky, Irwin; Pell, Arthur R.

    This guide to interviewing and selecting elementary school teachers and administrators covers evaluating resumes, establishing rapport with job applicants, considering legal aspects of interviewing, controlling the interview, evaluating the applicant, closing the interview, checking references, and maintaining interview records. Job-related…

  9. Interviewing and Selecting High School Teachers and Administrative Personnel. A Guide for the Screening Interview. One of the Better Employment Interviewing Series.

    ERIC Educational Resources Information Center

    Rooney, Thomas F., Jr.; Pell, Arthur R.

    This guide to interviewing and selecting high school teachers and administrators covers evaluating resumes, establishing rapport with job applicants, considering the legal aspects of interviewing, controlling the interview, evaluating the applicant, closing the interview, checking references, and maintaining interview records. Job-related…

  10. Scintillation correction for astronomical photometry on large and extremely large telescopes with tomographic atmospheric reconstruction

    NASA Astrophysics Data System (ADS)

    Osborn, J.

    2015-01-01

    We describe a new concept to correct for scintillation noise on high-precision photometry in large and extremely large telescopes using telemetry data from adaptive optics (AO) systems. Most wide-field AO systems designed for the current era of very large telescopes and the next generation of extremely large telescopes require several guide stars to probe the turbulent atmosphere in the volume above the telescope. These data can be used to tomographically reconstruct the atmospheric turbulence profile and phase aberrations of the wavefront in order to assist wide-field AO correction. If the wavefront aberrations and altitude of the atmospheric turbulent layers are known from this tomographic model, then the effect of the scintillation can be calculated numerically and used to normalize the photometric light curve. We show through detailed Monte Carlo simulation that for an 8 m telescope with a 16 × 16 AO system we can reduce the scintillation noise by an order of magnitude.

  11. The Do/ scintillating fiber tracker

    SciTech Connect

    Bross, A.; Gutierrez, G.; Grunendahl, S.; Lincoln, D.; Ramberg, E.; Ray, R.; Ruchti, R.; Warchol, J.; Wayne, M.; Choic, S.

    1998-11-01

    The Do/ detector is being upgraded in preparation for the next collider run at Fermilab. The Central Fiber Tracker discussed in this report is a major component of the Do/ upgrade. The expected Tevatron luminosity of 2{times}10{sup 32} cm{sup {minus}2} sec{sup {minus}1}, the 132ns bunch crossing time, and the Do/ detector constraints of a 2 Tesla solenoid and a 52 cm lever arm, make a scintillating fiber based tracker an optimal choice for the upgrade of the Do/ detector. {copyright} {ital 1998 American Institute of Physics.}

  12. Photodetectors for Scintillator Proportionality Measurement

    SciTech Connect

    Moses, William W.; Choong, Woon-Seng; Hull, Giulia; Payne, Steve; Cherepy, Nerine; Valentine, J.D.

    2010-10-18

    We evaluate photodetectors for use in a Compton Coincidence apparatus designed for measuring scintillator proportionality. There are many requirements placed on the photodetector in these systems, including active area, linearity, and the ability to accurately measure low light levels (which implies high quantum efficiency and high signal-to-noise ratio). Through a combination of measurement and Monte Carlo simulation, we evaluate a number of potential photodetectors, especially photomultiplier tubes and hybrid photodetectors. Of these, we find that the most promising devices available are photomultiplier tubes with high ({approx}50%) quantum efficiency, although hybrid photodetectors with high quantum efficiency would be preferable.

  13. Screening for Lung Cancer.

    PubMed

    Stiles, Brendon M; Pua, Bradley; Altorki, Nasser K

    2016-07-01

    Lung cancer is a global health burden and is among the most common and deadliest of all malignancies worldwide. The goal of screening programs is to detect tumors in earlier, curable stages, consequently reducing disease-specific mortality. The issue of screening has great relevance to thoracic surgeons, who should play a leading role in the debate over screening and its consequences. The burden is on thoracic surgeons to work in a multidisciplinary setting to guide and treat these patients safely and responsibly, ensuring low morbidity and mortality of potential diagnostic or therapeutic interventions. PMID:27261909

  14. 4/6-GHz ionospheric scintillation measurements during the peak of sunspot cycle 21

    SciTech Connect

    Fang, D.J.; Pontes, M.S.

    1981-01-01

    Analyses of power spectral density confirm an f to the -3 dependence for weak scintillations, which, it is noted, can be explained by the conventional weak scattering theory for a thick screen with a power law electron density fluctuation spectrum of p equals 4. Data gathered from 1977 to 1980 at the Hong Kong Earth Station provide further insight into 4- and 6-GHz scintillations during maximum solar activity. Such characteristics as occurrence frequencies, durations, global scales, and spectral roll-off slopes are unique in that they had not been observed in previous years. Peak-to-peak fluctuations of up to 14-dB magnitude are observed for which the f to the -3 power spectrum dependence is no longer valid. In terms of cumulative statistics, a model of scintillation increase as a function of solar activities is developed for engineering applications.

  15. Spectral analysis of scintillation data taken from an aircraft. Part I. Final report Oct 76-Oct 79

    SciTech Connect

    Barrett, T.B.

    1980-02-01

    This report provides theoretical background material for the development of a thin phase screen model for radio scintillation. This model is then used to derive an expression for the expected amplitude scintillation spectra (spectral density funciton) which might be observed in a geometry which includes a satellite based transmitter, an aircraft based receiver and a 'thin', intermediate scintillation-producing medium. A computer procedure was developed for testing the model under various geometries and for various parameters describing the 'bulk' properties statistical properties of the medium. In addition to the development of a theoretical model, this report includes material on experimental spectral analysis and, in particular, details on a spectral analysis procedure which was used on amplitude scintillation and data gathered from an aircraft in geomagnetic equatorial regions.

  16. Multilayer scintillation spectrometer for charged pionium detection

    NASA Astrophysics Data System (ADS)

    Krasnov, V. A.; Karnyushina, L. V.; Kuznetsov, S. N.; Kurepin, A. B.; Livanov, A. N.; Pilyar, A. V.

    2013-01-01

    The design description and characteristics of a 14-layer scintillation spectrometer for meson recording are given. The results from testing the spectrometer, calibrating it with cosmic-ray particles, and using the particle beams at energies reaching 1 GeV are presented. The spectrometer design is based on flat scintillation plates glued with wavelength-shifting optic fibers.

  17. Scintillator handbook with emphasis on cesium iodide

    NASA Technical Reports Server (NTRS)

    Tidd, J. L.; Dabbs, J. R.; Levine, N.

    1973-01-01

    This report provides a background of reasonable depth and reference material on scintillators in general. Particular attention is paid to the cesium iodide scintillators as used in the High Energy Astronomy Observatory (HEAO) experiments. It is intended especially for use by persons such as laboratory test personnel who need to obtain a working knowledge of these materials and their characteristics in a short time.

  18. Binderless composite scintillator for neutron detection

    DOEpatents

    Hodges, Jason P [Knoxville, TN; Crow, Jr; Lowell, M [Oak Ridge, TN; Cooper, Ronald G [Oak Ridge, TN

    2009-03-10

    Composite scintillator material consisting of a binderless sintered mixture of a Lithium (Li) compound containing .sup.6Li as the neutron converter and Y.sub.2SiO.sub.5:Ce as the scintillation phosphor, and the use of this material as a method for neutron detection. Other embodiments of the invention include various other Li compounds.

  19. Development of scintillation materials for PET scanners

    NASA Astrophysics Data System (ADS)

    Korzhik, Mikhail; Fedorov, Andrei; Annenkov, Alexander; Borissevitch, Andrei; Dossovitski, Alexei; Missevitch, Oleg; Lecoq, Paul

    2007-02-01

    The growing demand on PET methodology for a variety of applications ranging from clinical use to fundamental studies triggers research and development of PET scanners providing better spatial resolution and sensitivity. These efforts are primarily focused on the development of advanced PET detector solutions and on the developments of new scintillation materials as well. However Lu containing scintillation materials introduced in the last century such as LSO, LYSO, LuAP, LuYAP crystals still remain the best PET species in spite of the recent developments of bright, fast but relatively low density lanthanum bromide scintillators. At the same time Lu based materials have several drawbacks which are high temperature of crystallization and relatively high cost compared to alkali-halide scintillation materials. Here we describe recent results in the development of new scintillation materials for PET application.

  20. Interstellar scattering of pulsar radiation. 1: Scintillation

    NASA Technical Reports Server (NTRS)

    Backer, D. C.

    1974-01-01

    An investigation of the intensity fluctuations of 28 pulsars near 0.4 GHz indicates that scintillation spectra have a Gaussian shape, scintillation indices are near unity, and the scintillation bandwidth depends linearly on dispersion measure. Observations near 2.5 GHz suggest a strong dependence of the frequency at which scintillation indices fall below unity on dispersion measure. Multistation measurements of scintillation provide values or limits for the scale size of the scattering diffraction pattern. The dependences of scattering parameters on dispersion measure is discussed in terms of the current models. It is suggested that any line of sight through the galaxy encounters increasingly rare, increasingly large deviations of thermal electron density on the scale of 10 to the 11th power cm.

  1. Equitorial scintillations: Advances since ISEA-6

    NASA Astrophysics Data System (ADS)

    Basu, S.

    1985-01-01

    Since the last equatorial aeronomy meeting in 1980, our understanding of the morphology of equatorial scintillations has advanced greatly due to more intensive observations at the equatorial anomaly locations in the different longitude zones. The unmistakable effect of the sunspot cycle in controlling irregularity belt width and electron concentration responsible for strong scintillation in the GHz range has been demonstrated. The fact that night-time F-region dynamics is an important factor in controlling the magnitude of scintillations has been recognized by interpreting scintillation observations in the light of realistic models of total electron content at various longitudes. A hypothesis based on the alignment of the solar terminator with the geomagnetic flux tubes as an indicator of enhanced scintillation occurrence and another based on the influence of a transequatorial thermospheric neutral wind have been postulated to describe the observed longitudinal variation.

  2. Extruded scintillator for the calorimetry applications

    SciTech Connect

    Dyshkant, A.; Rykalin, V.; Pla-Dalmau, A.; Beznosko, D.; /SUNY, Stony Brook

    2006-08-01

    An extrusion line has been installed and successfully operated at FNAL (Fermi National Accelerator Laboratory) in collaboration with NICADD (Northern Illinois Center for Accelerator and Detector Development). This new Facility will serve to further develop and improve extruded plastic scintillator. Recently progress has been made in producing co-extruded plastic scintillator, thus increasing the potential HEP applications of this Facility. The current R&D work with extruded and co-extruded plastic scintillator for a potential ALICE upgrade, the ILC calorimetry program and the MINERvA experiment show the attractiveness of the chosen strategy for future experiments and calorimetry. We extensively discuss extruded and co-extruded plastic scintillator in calorimetry in synergy with new Solid State Photomultipliers. The characteristics of extruded and co-extruded plastic scintillator will be presented here as well as results with non-traditional photo read-out.

  3. Extruded scintillator for the Calorimetry applications

    SciTech Connect

    Dyshkant, A.; Rykalin, V.; Pla-Dalmau, A.; Beznosko, D.

    2006-10-27

    An extrusion line has been installed and successfully operated at FNAL (Fermi National Accelerator Laboratory) in collaboration with NICADD (Northern Illinois Center for Accelerator and Detector Development). This new Facility will serve to further develop and improve extruded plastic scintillator. Recently progress has been made in producing co-extruded plastic scintillator, thus increasing the potential HEP applications of this Facility. The current R and D work with extruded and co-extruded plastic scintillator for a potential ALICE upgrade, the ILC calorimetry program and the MINERvA experiment show the attractiveness of the chosen strategy for future experiments and calorimetry. We extensively discuss extruded and co-extruded plastic scintillator in calorimetry in synergy with new Solid State Photomultipliers. The characteristics of extruded and co-extruded plastic scintillator will be presented here as well as results with non-traditional photo read-out.

  4. Scintillation proximity assay using polymeric membranes

    SciTech Connect

    Mansfield, R.K.

    1992-01-01

    Liquid scintillation counting (LSC) is typically used to quantify electron emitting isotopes. In LSC, radioactive samples are dissolved in an organic fluor solution (scintillation cocktail) to ensure that the label is close enough to the fluor molecules to be detected. Although efficient, scintillation cocktail is neither specific or selective for samples labeled with the same radioisotope. Scintillation cocktail is flammable posing significant health risks to the user and is expensive to purchase and discard. Scintillation Proximity Assay (SPA) is a radioanalytical technique where only those radiochemical entities (RCE's) bound to fluor containing matrices are detected. Only bound RCE's are in close enough proximity the entrapped fluor molecules to induce scintillations. Unbound radioligands are too far removed from the fluor molecules to be detected. The research in this dissertation focused on the development and evaluation of fluor-containing membranes (scintillation proximity membranes, SP membranes) to be used for specific radioanalytical techniques without using scintillation cocktail. Polysulfone and PVC SP membranes prepared in our laboratory were investigated for radioimmunossay (RIA) where only bound radioligand is detected, thereby eliminating the separation step impeding the automation of RIA. These SP membranes performed RIA where the results were nearly identical to commercial SP microbeads. SP membranes functionalized with quaternary ammonium hydroxide moieties were able to trap and quantify [sup 14]CO[sub 2] without using liquid scintillation cocktail. RCE's bound in the pore structure of SP membranes are intimate with the entrapped fluor providing the geometry needed for high detection efficiencies. Absorbent SP membranes were used in radiation surveys and were shown to be as effective as conventional survey techniques using filter paper and scintillation cocktail.

  5. Scintillation Effects on Space Shuttle GPS Data

    NASA Technical Reports Server (NTRS)

    Goodman, John L.; Kramer, Leonard

    2001-01-01

    Irregularities in ionospheric electron density result in variation in amplitude and phase of Global Positioning System (GPS) signals, or scintillation. GPS receivers tracking scintillated signals may lose carrier phase or frequency lock in the case of phase sc intillation. Amplitude scintillation can cause "enhancement" or "fading" of GPS signals and result in loss of lock. Scintillation can occur over the equatorial and polar regions and is a function of location, time of day, season, and solar and geomagnetic activity. Mid latitude regions are affected only very rarely, resulting from highly disturbed auroral events. In the spring of 1998, due to increasing concern about scintillation of GPS signals during the upcoming solar maximum, the Space Shuttle Program began to assess the impact of scintillation on Collins Miniaturized Airborne GPS Receiver (MAGR) units that are to replace Tactical Air Control and Navigation (TACAN) units on the Space Shuttle orbiters. The Shuttle Program must determine if scintillation effects pose a threat to safety of flight and mission success or require procedural and flight rule changes. Flight controllers in Mission Control must understand scintillation effects on GPS to properly diagnose "off nominal" GPS receiver performance. GPS data from recent Space Shuttle missions indicate that the signals tracked by the Shuttle MAGR manifest scintillation. Scintillation is observed as anomalous noise in velocity measurements lasting for up to 20 minutes on Shuttle orbit passes and are not accounted for in the error budget of the MAGR accuracy parameters. These events are typically coincident with latitude and local time occurrence of previously identified equatorial spread F within about 20 degrees of the magnetic equator. The geographic and seasonal history of these events from ground-based observations and a simple theoretical model, which have potential for predicting events for operational purposes, are reviewed.

  6. The improved scintillation crystal lead tungstate scintillation for PET

    NASA Astrophysics Data System (ADS)

    Wan, Youbao; WU, Rurong; Xiao, Linrong; Zhang, Jianxin; Yang, Peizhi; Yan, Hui

    2009-07-01

    As a valuable material for the detecting of γ-ray, PbWO4 and BaF2:PbWO4 crystals were grown by a novel multi-crucible temperature gradient system developed by ourselves. Utilizing a topical partial heating method, this system can form a topical partial high temperature in its hearth. Thus this system could melt raw materials in step by step as requirement. The advantage of this method is that there would be solid obstruct left on the melt in the procedure of the crystal growing up. The left obstruct could prevent the volatilization of the component in the melt. Hence it is helpful for the composition homogenization in the crystal. The system also offers a sustaining device for multi-crucibles and thus it can grow many crystals simultaneity. The optical properties and scintillation properties of the crystals were studied. The results reveal that the ions doping improves the scintillation properties of the crystal. The transmittance spectra show that the transmittance of BaF2:PbWO4 crystals are better than that of PbWO4 crystals. For the PbWO4 crystals, their absorption edge is at 325nm, and their maximum transmittance is 68%. For the BaF2:PbWO4 crystals, their absorption edge is at 325nm and their maximum transmittance is upto76%. The X-ray excited luminescence spectra shows that the luminescence peak is at 420nm for the samples of PbWO4 crystal while the peak is at 430nm for the samples of BaF2:PbWO4 crystal respectively. The luminescence intensity of the samples of BaF2:PbWO4 crystal is about two times than that of PbWO4 crystal. And their peak shape is different for the two kind of crystal. The light yield of BaF2:PbWO4 crystals is about 2.9 times than that of PbWO4 crystal Analyzing these scintillation properties, we find that the VPb 3+ and VO- defects do harm for the optical properties of the crystal. Ions doping method could reduce the defect concentration and improving its illumination performance of the crystal. Specially, the doped F- ions in O2- site can

  7. Disparities in Adherence to Screening Guidelines for Diabetic Retinopathy in the United States: A Comprehensive Review and Guide for Future Directions.

    PubMed

    Fathy, Cherie; Patel, Shriji; Sternberg, Paul; Kohanim, Sahar

    2016-01-01

    Diabetic retinopathy (DR) is the leading cause of new-onset blindness in American adults aged 20-74 years old. The number of diabetics living with diagnosed DR increased by 89%, from 4.06 million to 7.69 million, between 2000 and 2010. Projected numbers from the Vision Health Initiative by the CDC predict that the rate of DR will triple by 2050, from 5.5 million people living with DR to 16 million. Screening guidelines aim to detect cases early because the treatments for DR can reduce severe vision loss by up to 94%. However, adherence to these guidelines is quite low. It is estimated that more than half of patients with diabetes may fail to receive necessary screening. Risk factors for non-screening discussed in this study include low health literacy, lack of access to care, pregnancy, physician adherence to guidelines, unique factors present in different minority populations, gender and age disparities, and living in rural regions. This paper also aims to address potential interventions that may improve adherence rates. PMID:27116205

  8. Speeding up directed evolution: Combining the advantages of solid-phase combinatorial gene synthesis with statistically guided reduction of screening effort.

    PubMed

    Hoebenreich, Sabrina; Zilly, Felipe E; Acevedo-Rocha, Carlos G; Zilly, Matías; Reetz, Manfred T

    2015-03-20

    Efficient and economic methods in directed evolution at the protein, metabolic, and genome level are needed for biocatalyst development and the success of synthetic biology. In contrast to random strategies, semirational approaches such as saturation mutagenesis explore the sequence space in a focused manner. Although several combinatorial libraries based on saturation mutagenesis have been reported using solid-phase gene synthesis, direct comparison with traditional PCR-based methods is currently lacking. In this work, we compare combinatorial protein libraries created in-house via PCR versus those generated by commercial solid-phase gene synthesis. Using descriptive statistics and probabilistic distributions on amino acid occurrence frequencies, the quality of the libraries was assessed and compared, revealing that the outsourced libraries are characterized by less bias and outliers than the PCR-based ones. Afterward, we screened all libraries following a traditional algorithm for almost complete library coverage and compared this approach with an emergent statistical concept suggesting screening a lower portion of the protein sequence space. Upon analyzing the biocatalytic landscapes and best hits of all combinatorial libraries, we show that the screening effort could have been reduced in all cases by more than 50%, while still finding at least one of the best mutants. PMID:24921161

  9. Measurement of radiation damage of water-based liquid scintillator and liquid scintillator

    DOE PAGESBeta

    Bignell, L. J.; Diwan, M. V.; Hans, S.; Jaffe, D. E.; Rosero, R.; Vigdor, S.; Viren, B.; Worcester, E.; Yeh, M.; Zhang, C.

    2015-10-19

    Liquid scintillating phantoms have been proposed as a means to perform real-time 3D dosimetry for proton therapy treatment plan verification. We have studied what effect radiation damage to the scintillator will have upon this application. We have performed measurements of the degradation of the light yield and optical attenuation length of liquid scintillator and water-based liquid scintillator after irradiation by 201 MeV proton beams that deposited doses of approximately 52 Gy, 300 Gy, and 800 Gy in the scintillator. Liquid scintillator and water-based liquid scintillator (composed of 5% scintillating phase) exhibit light yield reductions of 1.74 ± 0.55 % andmore » 1.31 ± 0.59 % after ≈ 800 Gy of proton dose, respectively. Some increased optical attenuation was observed in the irradiated samples, the measured reduction to the light yield is also due to damage to the scintillation light production. Based on our results and conservative estimates of the expected dose in a clinical context, a scintillating phantom used for proton therapy treatment plan verification would exhibit a systematic light yield reduction of approximately 0.1% after a year of operation.« less

  10. Measurement of radiation damage of water-based liquid scintillator and liquid scintillator

    SciTech Connect

    Bignell, L. J.; Diwan, M. V.; Hans, S.; Jaffe, D. E.; Rosero, R.; Vigdor, S.; Viren, B.; Worcester, E.; Yeh, M.; Zhang, C.

    2015-10-19

    Liquid scintillating phantoms have been proposed as a means to perform real-time 3D dosimetry for proton therapy treatment plan verification. We have studied what effect radiation damage to the scintillator will have upon this application. We have performed measurements of the degradation of the light yield and optical attenuation length of liquid scintillator and water-based liquid scintillator after irradiation by 201 MeV proton beams that deposited doses of approximately 52 Gy, 300 Gy, and 800 Gy in the scintillator. Liquid scintillator and water-based liquid scintillator (composed of 5% scintillating phase) exhibit light yield reductions of 1.74 ± 0.55 % and 1.31 ± 0.59 % after ≈ 800 Gy of proton dose, respectively. Some increased optical attenuation was observed in the irradiated samples, the measured reduction to the light yield is also due to damage to the scintillation light production. Based on our results and conservative estimates of the expected dose in a clinical context, a scintillating phantom used for proton therapy treatment plan verification would exhibit a systematic light yield reduction of approximately 0.1% after a year of operation.

  11. Segmented crystalline scintillators: An initial investigation of high quantum efficiency detectors for megavoltage x-ray imaging

    SciTech Connect

    Sawant, Amit; Antonuk, Larry E.; El-Mohri, Youcef; Zhao Qihua; Li Yixin; Su Zhong; Wang Yi; Yamamoto, Jin; Du Hong; Cunningham, Ian; Klugerman, Misha; Shah, Kanai

    2005-10-15

    Electronic portal imaging devices (EPIDs) based on indirect detection, active matrix flat panel imagers (AMFPIs) have become the technology of choice for geometric verification of patient localization and dose delivery in external beam radiotherapy. However, current AMFPI EPIDs, which are based on powdered-phosphor screens, make use of only {approx}2% of the incident radiation, thus severely limiting their imaging performance as quantified by the detective quantum efficiency (DQE) ({approx}1%, compared to {approx}75% for kilovoltage AMFPIs). With the rapidly increasing adoption of image-guided techniques in virtually every aspect of radiotherapy, there exist strong incentives to develop high-DQE megavoltage x-ray imagers, capable of providing soft-tissue contrast at very low doses in megavoltage tomographic and, potentially, projection imaging. In this work we present a systematic theoretical and preliminary empirical evaluation of a promising, high-quantum-efficiency, megavoltage x-ray detector design based on a two-dimensional matrix of thick, optically isolated, crystalline scintillator elements. The detector is coupled with an indirect detection-based active matrix array, with the center-to-center spacing of the crystalline elements chosen to match the pitch of the underlying array pixels. Such a design enables the utilization of a significantly larger fraction of the incident radiation (up to 80% for a 6 MV beam), through increases in the thickness of the crystalline elements, without loss of spatial resolution due to the spread of optical photons. Radiation damage studies were performed on test samples of two candidate scintillator materials, CsI(Tl) and BGO, under conditions relevant to radiotherapy imaging. A detailed Monte Carlo-based study was performed in order to examine the signal, spatial spreading, and noise properties of the absorbed energy for several segmented detector configurations. Parameters studied included scintillator material, septal wall

  12. Scintillation Breakdowns in Chip Tantalum Capacitors

    NASA Technical Reports Server (NTRS)

    Teverovsky, Alexander

    2008-01-01

    Scintillations in solid tantalum capacitors are momentarily local breakdowns terminated by a self-healing or conversion to a high-resistive state of the manganese oxide cathode. This conversion effectively caps the defective area of the tantalum pentoxide dielectric and prevents short-circuit failures. Typically, this type of breakdown has no immediate catastrophic consequences and is often considered as nuisance rather than a failure. Scintillation breakdowns likely do not affect failures of parts under surge current conditions, and so-called "proofing" of tantalum chip capacitors, which is a controllable exposure of the part after soldering to voltages slightly higher than the operating voltage to verify that possible scintillations are self-healed, has been shown to improve the quality of the parts. However, no in-depth studies of the effect of scintillations on reliability of tantalum capacitors have been performed so far. KEMET is using scintillation breakdown testing as a tool for assessing process improvements and to compare quality of different manufacturing lots. Nevertheless, the relationship between failures and scintillation breakdowns is not clear, and this test is not considered as suitable for lot acceptance testing. In this work, scintillation breakdowns in different military-graded and commercial tantalum capacitors were characterized and related to the rated voltages and to life test failures. A model for assessment of times to failure, based on distributions of breakdown voltages, and accelerating factors of life testing are discussed.

  13. Estimation of Fano factor in inorganic scintillators

    NASA Astrophysics Data System (ADS)

    Bora, Vaibhav; Barrett, Harrison H.; Fastje, David; Clarkson, Eric; Furenlid, Lars; Bousselham, Abdelkader; Shah, Kanai S.; Glodo, Jarek

    2016-01-01

    The Fano factor of an integer-valued random variable is defined as the ratio of its variance to its mean. Correlation between the outputs of two photomultiplier tubes on opposite faces of a scintillation crystal was used to estimate the Fano factor of photoelectrons and scintillation photons. Correlations between the integrals of the detector outputs were used to estimate the photoelectron and photon Fano factor for YAP:Ce, SrI2:Eu and CsI:Na scintillator crystals. At 662 keV, SrI2:Eu was found to be sub-Poisson, while CsI:Na and YAP:Ce were found to be super-Poisson. An experiment setup inspired from the Hanbury Brown and Twiss experiment was used to measure the correlations as a function of time between the outputs of two photomultiplier tubes looking at the same scintillation event. A model of the scintillation and the detection processes was used to generate simulated detector outputs as a function of time for different values of Fano factor. The simulated outputs from the model for different Fano factors was compared to the experimentally measured detector outputs to estimate the Fano factor of the scintillation photons for YAP:Ce, LaBr3:Ce scintillator crystals. At 662 keV, LaBr3:Ce was found to be sub-Poisson, while YAP:Ce was found to be close to Poisson.

  14. Equatorial scintillations: advances since ISEA-6

    SciTech Connect

    Not Available

    1985-01-01

    Our understanding of the morphology of equatorial scintillations has advanced due to more intensive observations at the equatorial anomaly locations in the different longitude zones. The unmistakable effect of the sunspot cycle in controlling irregularity belt width and electron concentration responsible for strong scintillation in the controlling the magnitude of scintillations has been recognized by interpreting scintillation observations inthe light of realistic models of total electron content at various longitudes. A hypothesis based on the alignment of the solar terminator with the geomagnetic flux tubes as an indicator of enhanced scintillation occurrence and another based on the influence of a transequatorial thermospheric neutral wind have been postulated to describe the observed longitudinal variation. A distinct class of equatorial irregularities known as the bottomside sinusoidal (BSS) type was identified. These irregularities occur in very large patches, sometimes in excess of several thousand kilometers in the E-W direction and are associated with frequency spread on ionograms. Scintillations caused by such irregularities exist only in the VHF band, exhibit Fresnel oscillations in intensity spectra and are found to give rise to extremely long durations (approx. several hours) of uninterrrupted scintillations.

  15. Pulse shaping analysis with LAB-based liquid scintillators

    NASA Astrophysics Data System (ADS)

    Lee, J. S.; Kim, Y. H.; Lee, K. B.; Lee, M. K.; Ma, K. J.; Jeon, E. J.; Kim, J. Y.; Kim, N. Y.; Kim, Y. D.; Lee, J. Y.

    2012-02-01

    We report on a pulse shaping analysis for alpha-beta discrimination using a linear alkylbenzene (LAB)-based liquid scintillator developed for reactor neutrino experiments. The scintillation properties are measured with an internal alpha source diluted in the same scintillator and an external gamma source. The comparison of the fast and the slow parts in the signal waveforms provide clear separations of alpha and gamma events in the liquid scintillator. The discrimination power is compared between the LAB-based liquid scintillator and other commercially available liquid scintillators. The potential use of this scintillator when loaded with 6Li is discussed with regard to neutron measurements.

  16. Fast scintillation counters with WLS bars

    SciTech Connect

    Bezzubov, V.; Denisov, S.; Dyshkant, A.; Evdokimov, V.; Galyaev, A.; Goncharov, P.; Gurzhiev, S.; Kostritsky, A.; Kozelov, A.; Stoianova, D.; Denisov, D.; Diehl, H.T.; Ito, A.S.; Johns, K.

    1998-11-01

    The Do/ collaboration is building 4608 scintillation counters to upgrade forward muon system for the next Fermilab Collider run. Each counter consists of 12.7 mm thick scintillator plate with two WLS bars along two sides for the light collection. With average 10{sup 2} photoelectrons from {ital mip} particle the counters provide time resolution below 1ns and have good energy resolution. Results of Bicron 404A scintillator and Kumarin 30 WLS aging under irradiation up to 3Mrad are presented. With specially designed magnetic shielding counters can operate in magnetic filed up to 500G. {copyright} {ital 1998 American Institute of Physics.}

  17. Manufacturing and studying of new polystyrene scintillators

    NASA Astrophysics Data System (ADS)

    Senchishin, Vitalij G.; Vasilchuk, Vladimir L.; Borysenko, Artem; Lebedev, Valentin N.; Adadurov, Alexander F.; Kalinichenko, Alexander I.; Titskaja, Valentina D.; Koba, Valentina S.; Khlapova, Nina P.; Pelipyagina, Ludmilla E.; Miroshnichenko, Ludmilla A.; Osadchenko, Valentina N.; Kluban, Nikolaj A.

    1999-10-01

    New type of polystyrene-based scintillators UPS98GC were tested regarding long term stability, radiation hardness and light yield uniformity for different doses and dose-rate levels of gamma radiation. They were compared to SCSN-81 produced by Kuraray Co. which has often used in high-energy physics experiments. The dependence of scintillator properties on radiation dose rates as well on total dose values is studied. It is shown that for relatively small dose rate, closed to those expected during scintillator lifetime, our UPS98GC does not yield to SCSN-81.

  18. Scintillation Noise in Exoplanet Transit Photometry

    NASA Astrophysics Data System (ADS)

    Föhring, Dóra; Wilson, Richard; Osborn, James; Dhillon, Vik

    2015-04-01

    Transit photometry is a powerful technique for studying exoplanets. Transit observations from the ground of targets of magnitude V= 10 or brighter, however, are limited by scintillation noise due to Earth's atmosphere. Through turbulence profiling using instruments such as the stereo-SCIDAR, we have shown to able to accurately model scintillation noise, which is essential in order to fully account for the error budget of the observation. Through numerical modelling we find that employing scintillation reducing techniques enables an improvement of a factor between 1.36 — 1.6 on the astrophysical parameters.

  19. Measurement of light emission in scintillation vials

    SciTech Connect

    Duran Ramiro, M. Teresa; Garcia-Torano, Eduardo

    2005-09-15

    The efficiency and energy resolution of liquid scintillation counting (LSC) systems are strongly dependent on the optical characteristics of scintillators, vials, and reflectors. This article presents the results of measurements of the light-emission profile of scintillation vials. Two measurement techniques, autoradiographs and direct measurements with a photomultiplier tube, have been used to obtain light-emission distribution for standard vials of glass, etched glass and polyethylene. Results obtained with both techniques are in good agreement. For the first time, the effect of the meniscus in terms of light contribution has been numerically estimated. These results can help design LSC systems that are more efficient in terms of light collection.

  20. Scintillation Light from Cosmic-Ray Muons in Liquid Argon

    SciTech Connect

    Whittington, Denver Wade; Mufson, S.; Howard, B.

    2015-11-13

    This paper reports the results of an experiment to directly measure the time-resolved scintillation signal from the passage of cosmic-ray muons through liquid argon. Scintillation light from these muons is of value to studies of weakly-interacting particles in neutrino experiments and dark matter searches. The experiment was carried out at the TallBo dewar facility at Fermilab using prototype light guide detectors and electronics developed for the Deep Underground Neutrino Experiment. Two models are presented for the time structure of the scintillation light, a phenomenological model and a physically-motivated model. Both models find tT = 1:52 ms for the decay time constant of the Ar 2 triplet state. These models also show that the identification of the “early” light fraction in the phenomenological model, FE 25% of the signal, with the total light from singlet decays is an underestimate. The total fraction of singlet light is FS 36%, where the increase over FE is from singlet light emitted by the wavelength shifter through processes with long decay constants. The models were further used to compute the experimental particle identification parameter Fprompt, the fraction of light coming in a short time window after the trigger compared with the light in the total recorded waveform. The models reproduce quite well the typical experimental value 0.3 found by dark matter and double b-decay experiments, which suggests this parameter provides a robust metric for discriminating electrons and muons from more heavily ionizing particles.

  1. Scintillation light from cosmic-ray muons in liquid argon

    NASA Astrophysics Data System (ADS)

    Whittington, D.; Mufson, S.; Howard, B.

    2016-05-01

    This paper reports the results of an experiment to directly measure the time-resolved scintillation signal from the passage of cosmic-ray muons through liquid argon. Scintillation light from these muons is of value to studies of weakly-interacting particles in neutrino experiments and dark matter searches. The experiment was carried out at the TallBo dewar facility at Fermilab using prototype light guide detectors and electronics developed for the Deep Underground Neutrino Experiment. Two models are presented for the time structure of the scintillation light, a phenomenological model and a composite model. Both models find τT = 1.52 μs for the decay time constant of the Ar2* triplet state. These models also show that the identification of the ``early'' light fraction in the phenomenological model, FE ≈ 25% of the signal, with the total light from singlet decays is an underestimate. The total fraction of singlet light is FS ≈ 36%, where the increase over FE is from singlet light emitted by the wavelength shifter through processes with long decay constants. The models were further used to compute the experimental particle identification parameter Fprompt, the fraction of light coming in a short time window after the trigger compared with the light in the total recorded waveform. The models reproduce quite well the typical experimental value ~0.3 found by dark matter and double β-decay experiments, which suggests this parameter provides a robust metric for discriminating electrons and muons from more heavily ionizing particles.

  2. Formula optimization of the Jiashitang scar removal ointment and antiinflammatory compounds screening by NF-κB bioactivity-guided dual-luciferase reporter assay system.

    PubMed

    Gao, Jie; Tao, Jin; Zhang, Nannan; Liu, Yanjie; Jiang, Min; Hou, Yuanyuan; Wang, Qian; Bai, Gang

    2015-02-01

    Inflammation plays a role in scar formation; therefore, decreasing inflammation benefits scar removal. Jiashitang scar removal ointment (JST) is a commercially available traditional Chinese medicinal formulation. It is composed of extracts from Carthamus tinctorius L. (Car), Rheum officinale Baill. (Rhe), Salvia miltiorrhiza Beg. (Sal), and Panax notoginseng (Burk.) F. H. Chen (Pan), which are all herbs with potent antiinflammatory activities. Our aims are to optimize the formula of JST and to elucidate its antiinflammatory active components. Response surface methodology was applied to optimize proportions of the four herb extracts. The antiinflammatory effects were evaluated using in vitro and in vivo models. To screen for active components in this formula, a bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis was performed. After optimization, the antiinflammatory effects of the new formula were significantly superior to the original one. Screening identified 13 active ingredients: a series of saffiomin, emodin, salvianolic acid, tanshinone, and triterpenoid saponin derivatives. These active ingredients were predicted to exert nuclear factor-κB inhibiting effects through MAPK, PI3K/AKT, and NIK-IKK pathways. In conclusion, the original formula was successfully optimized with more potent antiinflammatory activity. These methods can be applied to researches of other formulas. PMID:25363818

  3. Equatorial scintillations: advances since ISEA-6

    NASA Astrophysics Data System (ADS)

    Basu, Sunanda; Basu, Santimay

    1985-10-01

    Since the last equatorial aeronomy meeting in 1980, our understanding of the morphology of equatorial scintillations has advanced greatly due to more intensive observations at the equatorial anomaly locations in the different longitude zones. The unmistakable effect of the sunspot cycle in controlling irregularity belt width and electron concentration responsible for strong scintillation in the GHz range has been demonstrated. The fact that night-time F-region dynamics is an important factor in controlling the magnitude of scintillations has been recognized by interpreting scintillation observations in the light of realistic models of total electron content at various longitudes. A hypothesis based on the alignment of the solar terminator with the geomagnetic flux tubes as an indicator of enhanced scintillation occurrence and another based on the influence of a transequatorial thermospheric neutral wind have been postulated to describe the observed longitudinal variation. A distinct class of equatorial irregularities known as the bottomside sinusoidal (BSS) type has been identified. Unlike equatorial bubbles, these irregularities occur in very large patches, sometimes in excess of several thousand kilometers in the E-W direction and are associated with frequency spread on ionograms. Scintillations caused by such irregularities exist only in the VHF band, exhibit Fresnel oscillations in intensity spectra and are found to give rise to extremely long durations (~ several hours) of uninterrupted scintillations. These irregularities maximize during solstices, so that in the VHF range, scintillation morphology at an equatorial station is determined by considering occurrence characteristics of both bubble type and BSS type irregularities. The temporal structure of scintillations in relation to the in situ measurements of irregularity spatial structure within equatorial bubbles has been critically examined. A two-component irregularity spectrum with a shallow slope ( p1

  4. Structure-guided design of fluorescent S-adenosylmethionine analogs for a high-throughput screen to target SAM-I riboswitch RNAs

    PubMed Central

    Hickey, Scott F.; Hammond, Ming C.

    2014-01-01

    Summary Many classes of S-adenosylmethionine (SAM)-binding RNAs and proteins are of interest as potential drug targets in diverse therapeutic areas, from infectious diseases to cancer. In the former case, the SAM-I riboswitch is an attractive target because this structured RNA element is found only in bacterial mRNAs and regulates multiple genes in several human pathogens. Here we describe the synthesis of stable and fluorescent analogs of SAM in which the fluorophore is introduced through a functionalizable linker to the ribose. A Cy5-labeled SAM analog was shown to bind several SAM-I riboswitches via in-line probing and fluorescence polarization (FP) assays, including one from Staphylococcus aureus that controls the expression of SAM synthetase in this organism. A fluorescent ligand displacement assay was developed and validated for high-throughput screening of compounds to target the SAM-I riboswitch class. PMID:24560607

  5. Elastic scintillation materials based on polyorganosiloxane

    SciTech Connect

    Grinev, B.V.; Andryushchenko, L.A.; Shershukov, V.M.; Ulanenko, K.B.; Minakova, R.A.; Sevastjanova, I.V.

    1994-12-31

    The developed elastic scintillators based on polymethyl-phenylsiloxane rubber are characterized by an elevated light output and a low toxicity. The increase of their light output is achieved by raising the content of phenyl chains, varying the chemical structure of luminescent additions and using isopropylnaphthalene. This high-boiling solvent introduced into the scintillation siloxane compositions is confined within siloxane matrix after the hardening of the rubber.

  6. Liquid scintillators for optical fiber applications

    DOEpatents

    Franks, Larry A.; Lutz, Stephen S.

    1982-01-01

    A multicomponent liquid scintillator solution for use as a radiation-to-light converter in conjunction with a fiber optic transmission system. The scintillator includes a quantity of 1, 2, 4, 5, 3H, 6H, 1 OH, tetrahydro-8-trifluoromethyl (1) benzopyrano (9, 9a, 1-gh) quinolizin-10-one (Coumarin) as a solute in a fluor solvent such as benzyl alcohol or pseudo-cumene. The use of BIBUQ as an additional or primary solute is also disclosed.

  7. Current status on plastic scintillators modifications.

    PubMed

    Bertrand, Guillaume H V; Hamel, Matthieu; Sguerra, Fabien

    2014-11-24

    Recent developments of plastic scintillators are reviewed, from 2000 to March 2014, distributed in two different chapters. First chapter deals with the chemical modifications of the polymer backbone, whereas modifications of the fluorescent probe are presented in the second chapter. All examples are provided with the scope of detection of various radiation particles. The main characteristics of these newly created scintillators and their detection properties are given. PMID:25335882

  8. Ternary liquid scintillator for optical fiber applications

    DOEpatents

    Franks, Larry A.; Lutz, Stephen S.

    1982-01-01

    A multicomponent liquid scintillator solution for use as a radiation-to-light converter in conjunction with a fiber optic transmission system. The scintillator includes a quantity of 5-amino-9-diethylaminobenz (a) phenoxazonium nitrate (Nile Blue Nitrate) as a solute in a fluor solvent such as benzyl alcohol. The use of PPD as an additional solute is also disclosed. The system is controllable by addition of a suitable quenching agent, such as phenol.

  9. Multi-GNSS for Ionospheric Scintillation Studies

    NASA Astrophysics Data System (ADS)

    Morton, Y.

    2015-12-01

    GNSS have been widely used for ionospheric monitoring. We anticipate over 160 GNSS satellites broadcasting 400 signals by 2023, nearly double the number today. With their well-defined signal structures, high spatial density and spectral diversity, GNSS offers low cost and distributed passive sensing of ionosphere effects. There are, however, many challenges to utilize GNSS resources to characterize and forecast ionospheric scintillation. Originally intended for navigation purposes, GNSS receivers are designed to filter out nuisance effects due to ionosphere effects. GNSS measurements are plagued with errors from multipath, oscillator jitters, processing artifacts, and neutral atmosphere effects. Strong scintillation events are often characterized by turbulent structures in ionosphere, causing simultaneous deep amplitude fading and abrupt carrier phase changes. The combined weak signal and high carrier dynamics imposes conflicting requirements for GNSS receiver design. Therefore, GNSS receivers often experience cycle slips and loss of lock of signals during strong scintillation events. High quality, raw GNSS signals bearing space weather signatures and robust receiver algorithms designed to capture these signatures are needed in order for GNSS to be a reliable and useful agent for scintillation monitoring and forecasting. Our event-driven, reconfigurable data collection system is designed to achieve this purpose. To date, our global network has collected ~150TB of raw GNSS data during space weather events. A suite of novel receiver processing algorithms has been developed by exploitating GNSS spatial, frequency, temporal, and constellation diversity to process signals experiencing challenging scintillation impact. The algorithms and data have advanced our understanding of scintillation impact on GNSS, lead to more robust receiver technologies, and enabled high spatial and temporal resolution depiction of ionosphere responses to solar and geomagnetic conditions. This

  10. Single crystal scintillator plates used for light weight material X-ray radiography

    NASA Astrophysics Data System (ADS)

    Tous, J.; Blazek, K.; Nikl, M.; Mares, J. A.

    2013-03-01

    Very thin scintillator imaging plates have recently become of great interest. In high resolution X-ray projection imaging, very thin scintillators of about 5-20 micrometres are used to achieve high spatial resolution. Such thin screens are mainly used in micro-CT and nano-CT systems with either micro-focus X-ray tubes or with synchrotron sources. This work deals with a high resolution CCD camera in connection with an optical system and different single crystal scintillators in application for low energy X-ray micro-radiography. The thin screens used were prepared by mechanical polishing from Y3Al5O12 or Lu3Al5O12 single crystals. The screens can be used in equipment for the detection of different kinds of radiation and particles (UV, VUV, electrons or ions or their beams, X- or gamma-rays). A high resolution open type micro-focus X-ray tube was used to achieve the high resolution. The results show that the single crystal plates exhibit high spatial resolution and high sensitivity to low energy X-rays resulting in high image contrast. The use of the plates is highly suitable for light weight (low Z) material X-ray radiography. The resolution achieved is demonstrated using a test grid. Several light weight objects are imaged using the thin plates.

  11. Crystal growth and scintillation properties of strontium iodide scintillators

    SciTech Connect

    van Loef, Edgar; Wilson, Cody; Cherepy, Nerine; Payne, Steven; Choong, Woon-Seng; Moses, William W.; Shah, Kanai

    2009-06-01

    Single crystals of SrI{sub 2}:Eu and SrI{sub 2}:Ce/Na were grown from anhydrous iodides by the vertical Bridgman technique in evacuated silica ampoules. Growth rates were of the order of 5-30 mm/day. Radioluminescence spectra of SrI{sub 2}:Eu and SrI{sub 2}:Ce/Na exhibit a broad band due to Eu{sup 2+} and Ce{sup 3+} emission, respectively. The maximum in the luminescence spectrum of SrI{sub 2}:Eu is found at 435 nm. The spectrum of SrI{sub 2}:Ce/Na exhibits a doublet peaking at 404 and 435 nm attributed to Ce{sup 3+} emission, while additional impurity - or defected - related emission is present at approximately 525 nm. The strontium iodide scintillators show very high light yields of up to 120,000 photons/MeV, have energy resolutions down to 3% at 662 keV (Full Width Half Maximum) and exhibit excellent light yield proportionality with a standard deviation of less than 5% between 6 and 460 keV.

  12. Scintillation Hole Observed by FORMOSAT-3/COSMIC

    NASA Astrophysics Data System (ADS)

    Chen, Shih Ping; Yenq Liu, Jann; Krishnanunni Rajesh, Panthalingal

    2013-04-01

    Ionospheric scintillations can significantly disturb satellite positioning, navigation, and communication. FORMOSAT-3/COSMIC provides the first 3-D global observation by solo instrument (radio occultation experiment, GOX). The GPS L-band amplitude fluctuation from 50Hz signal is received and recorded by F3/C GOX to calculate S4-index from 50-800km altitude. The global F3/C S4 index are subdivided and examined in various latitudes, longitudes, altitudes, and seasons during 2007-2012. The F-region scintillations in the equatorial and low-latitude ionosphere start around post-sunset period and often persist till post-midnight hours (0300 MLT, magnetic local time) during the March and September equinox as well as December Solstice seasons. The E-region scintillations reveal a clear solar zenith effect and yield pronounced intensities in mid-latitudes during the Summer Solstice seasons, which are well correlated with occurrences of the sporadic E-layer. It is interesting to find there is no scintillation, which is termed "scintillation hole", in the E region ranging from 80 to 130km altitude over the South Africa region, and become the most pronounced in November-January (December Solstice seasons or summer months). Other space-borne and ground based observations are use to confirm the existence of the scintillation hole.

  13. Development of Novel Polycrystalline Ceramic Scintillators

    SciTech Connect

    Wisniewska, Monika; Boatner, Lynn A; Neal, John S; Jellison Jr, Gerald Earle; Ramey, Joanne Oxendine; North, Andrea L; Wisniewski, Monica; Payzant, E Andrew; Howe, Jane Y; Lempicki, Aleksander; Brecher, Charlie; Glodo, J.

    2008-01-01

    For several decades most of the efforts to develop new scintillator materials have concentrated on high-light-yield inorganic single-crystals while polycrystalline ceramic scintillators, since their inception in the early 1980 s, have received relatively little attention. Nevertheless, transparent ceramics offer a promising approach to the fabrication of relatively inexpensive scintillators via a simple mechanical compaction and annealing process that eliminates single-crystal growth. Until recently, commonly accepted concepts restricted the polycrystalline ceramic approach to materials exhibiting a cubic crystal structure. Here, we report our results on the development of two novel ceramic scintillators based on the non-cubic crystalline materials: Lu SiO:Ce (LSO:Ce) and LaBr:Ce. While no evidence for texturing has been found in their ceramic microstructures, our LSO:Ce ceramics exhibit a surprisingly high level of transparency/ translucency and very good scintillation characteristics. The LSO:Ce ceramic scintillation reaches a light yield level of about 86% of that of a good LSO:Ce single crystal, and its decay time is even faster than in single crystals. Research on LaBr:Ce shows that translucent ceramics of the high-light-yield rare-earth halides can also be synthesized. Our LaBr:Ce ceramics have light yields above 42 000 photons/MeV (i.e., 70%of the single-crystal light yield).

  14. GPS phase scintillation correlated with auroral forms

    NASA Astrophysics Data System (ADS)

    Hampton, D. L.; Azeem, S. I.; Crowley, G.; Santana, J.; Reynolds, A.

    2013-12-01

    The disruption of radio wave propagation due to rapid changes in electron density caused by auroral precipitation has been observed for several decades. In a few cases the disruption of GPS signals has been attributed to distinct auroral arcs [Kintner, 2007; Garner, 2011], but surprisingly there has been no systematic study of the characteristics of the auroral forms that cause GPS scintillation. In the Fall of 2012 ASTRA deployed four CASES GPS receivers at UAF observatories in Alaska (Kaktovik, Fort Yukon, Poker Flat and Gakona) specifically to address the effects of auroral activity on the high latitude ionosphere. We have initiated an analysis that compares the phase scintillation, recorded at high cadence, with filtered digital all-sky camera data to determine the auroral morphology and electron precipitation parameters that cause scintillation. From correlation studies from a single site (Poker Flat), we find that scintillation is well correlated with discrete arcs that have high particle energy flux (power per unit area), and not as well correlated with pulsating forms which typically have high characteristic energy, but lower energy flux . This indicates that the scintillation is correlated with the magnitude of the change in total electron density as expected. We will also report on ongoing work where we correlate the scintillation from the Fort Yukon receiver with the all-sky images at Poker Flat to determine the altitude that produces the greatest disturbance. These studies are aimed at a model that can predict the expected local disturbance to navigation due to auroral activity.

  15. Validating the use of scintillation proxies to study ionospheric scintillation over the Ugandan region

    NASA Astrophysics Data System (ADS)

    Amabayo, Emirant B.; Jurua, Edward; Cilliers, Pierre J.

    2015-06-01

    In this study, we compare the standard scintillation indices (S4 and σΦ) from a SCINDA receiver with scintillation proxies (S4p and | sDPR |) derived from two IGS GPS receivers. Amplitude (S4) and phase (σΦ) scintillation data were obtained from the SCINDA installed at Makerere University (0.34°N, 32.57°E). The corresponding amplitude (S4p) and phase (| sDPR |) scintillation proxies were derived from data archived by IGS GPS receivers installed at Entebbe (0.04°N, 32.44°E) and Mbarara (0.60°S, 30.74°E). The results show that for most of the cases analysed in this study, σΦ and | sDPR | are in agreement. Amplitude scintillation occurrence estimated using the S4p are fairly consistent with the standard S4, mainly between 17:00 UT and 21:00 UT, despite a few cases of over and under estimation of scintillation levels by S4p. Correlation coefficients between σΦ and the | sDPR | proxy revealed positive correlation. Generally, S4p and S4 exhibits both moderate and strong positive correlation. TEC depletions associated with equatorial plasma bubbles are proposed as the cause of the observed scintillation over the region. These equatorial plasma bubbles were evident along the ray paths to satellites with PRN 2, 15, 27 and 11 as observed from MBAR and EBBE. In addition to equatorial plasma bubbles, atmospheric gravity waves with periods similar to those of large scale traveling ionospheric disturbances were also observed as one of the mechanisms for scintillation occurrence. The outcome of this study implies that GPS derived scintillation proxies can be used to quantify scintillation levels in the absence of standard scintillation data in the equatorial regions.

  16. A Monte Carlo investigation of Swank noise for thick, segmented, crystalline scintillators for radiotherapy imaging

    PubMed Central

    Wang, Yi; Antonuk, Larry E.; El-Mohri, Youcef; Zhao, Qihua

    2009-01-01

    Thick, segmented scintillating detectors, consisting of 2D matrices of scintillator crystals separated by optically opaque septal walls, hold considerable potential for significantly improving the performance of megavoltage (MV) active matrix, flat-panel imagers (AMFPIs). Initial simulation studies of the radiation transport properties of segmented detectors have indicated the possibility of significant improvement in DQE compared to conventional MV AMFPIs based on phosphor screen detectors. It is therefore interesting to investigate how the generation and transport of secondary optical photons affect the DQE performance of such segmented detectors. One effect that can degrade DQE performance is optical Swank noise (quantified by the optical Swank factor Iopt), which is induced by depth-dependent variations in optical gain. In this study, Monte Carlo simulations of radiation and optical transport have been used to examine Iopt and zero-frequency DQE for segmented CsI:Tl and BGO detectors at different thicknesses and element-to-element pitches. For these detectors, Iopt and DQE were studied as a function of various optical parameters, including absorption and scattering in the scintillator, absorption at the top reflector and septal walls, as well as scattering at the side surfaces of the scintillator crystals. The results indicate that Iopt and DQE are only weakly affected by absorption and scattering in the scintillator, as well as by absorption at the top reflector. However, in some cases, these metrics were found to be significantly degraded by absorption at the septal walls and scattering at the scintillator side surfaces. Moreover, such degradations are more significant for detectors with greater thickness or smaller element pitch. At 1.016 mm pitch and with optimized optical properties, 40 mm thick segmented CsI:Tl and BGO detectors are predicted to provide DQE values of ∼29% and 42%, corresponding to improvement by factors of ∼29 and 42, respectively

  17. A scintillating gas detector for 2D dose measurements in clinical carbon beams.

    PubMed

    Seravalli, E; de Boer, M; Geurink, F; Huizenga, J; Kreuger, R; Schippers, J M; van Eijk, C W E; Voss, B

    2008-09-01

    A two-dimensional position sensitive dosimetry system based on a scintillating gas detector has been developed for pre-treatment verification of dose distributions in hadron therapy. The dosimetry system consists of a chamber filled with an Ar/CF4 scintillating gas mixture, inside which two cascaded gas electron multipliers (GEMs) are mounted. A GEM is a thin kapton foil with copper cladding structured with a regular pattern of sub-mm holes. The primary electrons, created in the detector's sensitive volume by the incoming beam, drift in an electric field towards the GEMs and undergo gas multiplication in the GEM holes. During this process, photons are emitted by the excited Ar/CF4 gas molecules and detected by a mirror-lens-CCD camera system. Since the amount of emitted light is proportional to the dose deposited in the sensitive volume of the detector by the incoming beam, the intensity distribution of the measured light spot is proportional to the 2D hadron dose distribution. For a measurement of a 3D dose distribution, the scintillating gas detector is mounted at the beam exit side of a water-bellows phantom, whose thickness can be varied in steps. In this work, the energy dependence of the output signal of the scintillating gas detector has been verified in a 250 MeV/u clinical 12C ion beam by means of a depth-dose curve measurement. The underestimation of the measured signal at the Bragg peak depth is only 9% with respect to an air-filled ionization chamber. This is much smaller than the underestimation found for a scintillating Gd2O2S:Tb ('Lanex') screen under the same measurement conditions (43%). Consequently, the scintillating gas detector is a promising device for verifying dose distributions in high LET beams, for example to check hadron therapy treatment plans which comprise beams with different energies. PMID:18695295

  18. A scintillating gas detector for 2D dose measurements in clinical carbon beams

    NASA Astrophysics Data System (ADS)

    Seravalli, E.; de Boer, M.; Geurink, F.; Huizenga, J.; Kreuger, R.; Schippers, J. M.; van Eijk, C. W. E.; Voss, B.

    2008-09-01

    A two-dimensional position sensitive dosimetry system based on a scintillating gas detector has been developed for pre-treatment verification of dose distributions in hadron therapy. The dosimetry system consists of a chamber filled with an Ar/CF4 scintillating gas mixture, inside which two cascaded gas electron multipliers (GEMs) are mounted. A GEM is a thin kapton foil with copper cladding structured with a regular pattern of sub-mm holes. The primary electrons, created in the detector's sensitive volume by the incoming beam, drift in an electric field towards the GEMs and undergo gas multiplication in the GEM holes. During this process, photons are emitted by the excited Ar/CF4 gas molecules and detected by a mirror-lens-CCD camera system. Since the amount of emitted light is proportional to the dose deposited in the sensitive volume of the detector by the incoming beam, the intensity distribution of the measured light spot is proportional to the 2D hadron dose distribution. For a measurement of a 3D dose distribution, the scintillating gas detector is mounted at the beam exit side of a water-bellows phantom, whose thickness can be varied in steps. In this work, the energy dependence of the output signal of the scintillating gas detector has been verified in a 250 MeV/u clinical 12C ion beam by means of a depth-dose curve measurement. The underestimation of the measured signal at the Bragg peak depth is only 9% with respect to an air-filled ionization chamber. This is much smaller than the underestimation found for a scintillating Gd2O2S:Tb ('Lanex') screen under the same measurement conditions (43%). Consequently, the scintillating gas detector is a promising device for verifying dose distributions in high LET beams, for example to check hadron therapy treatment plans which comprise beams with different energies.

  19. Scintillation gamma spectrometer for analysis of hydraulic fracturing waste products.

    PubMed

    Ying, Leong; O'Connor, Frank; Stolz, John F

    2015-01-01

    Flowback and produced wastewaters from unconventional hydraulic fracturing during oil and gas explorations typically brings to the surface Naturally Occurring Radioactive Materials (NORM), predominantly radioisotopes from the U238 and Th232 decay chains. Traditionally, radiological sampling are performed by sending collected small samples for laboratory tests either by radiochemical analysis or measurements by a high-resolution High-Purity Germanium (HPGe) gamma spectrometer. One of the main isotopes of concern is Ra226 which requires an extended 21-days quantification period to allow for full secular equilibrium to be established for the alpha counting of its progeny daughter Rn222. Field trials of a sodium iodide (NaI) scintillation detector offers a more economic solution for rapid screenings of radiological samples. To achieve the quantification accuracy, this gamma spectrometer must be efficiency calibrated with known standard sources prior to field deployments to analyze the radioactivity concentrations in hydraulic fracturing waste products. PMID:25734826

  20. An experimental method for the determination of spatial-frequency-dependent detective quantum efficiency (DQE) of scintillators used in X-ray imaging detectors

    NASA Astrophysics Data System (ADS)

    Kandarakis, I.; Cavouras, D.; Panayiotakis, G. S.; Triantis, D.; Nomicos, C. D.

    1997-02-01

    The spatial-frequency-dependent detective quantum efficiency (DQE) of imaging scintillators was studied independently of the optical detector (film, photocathode, or photodiode) employed in medical imaging devices. A method was developed to experimentally determine the scintillator DQE in terms of its luminescence efficiency (LE), quantum detection efficiency, modulation transfer function, and light emission spectrum. Gd 2O 2S : Tb, La 2O 2S : Tb, Y 2O 2S : Tb and ZnSCdS : Ag scintillating screens were prepared in laboratory and were excited to luminescence by a medical X-ray tube. Maximum DQE values varied between 0.13 and 0.33 depending on the scintillator material, the screen coating weight, and the tube voltage; Gd 2O 2S : Tb was superior to La 2O 2S : Tb followed by ZnSCdS : Ag and Y 2O 2S : Tb. This ranking was maintained at frequencies up to 100 cycles/cm. Considering the same material, DQE of thin screens was found superior to DQE of thicker screens at medium-to-high frequencies. The proposed method allows for the comparison of imaging characteristics of scintillating materials without the inclusion of optical detector imaging properties.

  1. First-principles Studies of the Optical Properties of Eu doped Barium Halides: From Storage Phosphor to Bright Scintillator

    NASA Astrophysics Data System (ADS)

    Canning, Andrew; Medasani, Bharat; Del Ben, Mauro; Bizarri, Gregory

    The Eu doped Ba mixed halide family BaBrX (X=F,Cl,Br,I) changes from being a widely used X-ray Storage Phosphor (BaBrF:Eu) to one of the brightest know new gamma ray detector scintillators (BaBrI:Eu). To help understand these contrasting optical properties and guide in the design of new and improved scintillator detectors, in collaboration with experimental groups, we have performed first principles theoretical studies of these materials. In particular we have studied their electron and hole trapping mechanisms and how that can explain their very different optical properties.

  2. High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.

    PubMed

    Bottini, Angel; Wu, Bainan; Barile, Elisa; De, Surya K; Leone, Marilisa; Pellecchia, Maurizio

    2016-04-19

    Recently we described a novel approach, named high-throughput screening (HTS) by NMR that allows the identification, from large combinatorial peptide libraries, of potent and selective peptide mimetics against a given target. Here, we deployed the "HTS by NMR" approach for the design of novel peptoid sequences targeting the N-terminal domain of Yersinia outer protein H (YopH-NT), a bacterial toxin essential for the virulence of Yersinia pestis. We aimed at disrupting the protein-protein interactions between YopH-NT and its cellular substrates, with the goal of inhibiting indirectly YopH enzymatic function. These studies resulted in a novel agent of sequence Ac-F-pY-cPG-d-P-NH2 (pY=phosphotyrosine; cPG=cyclopentyl glycine) with a Kd value against YopH-NT of 310 nm. We demonstrated that such a pharmacological inhibitor of YopH-NT results in the inhibition of the dephosphorylation by full-length YopH of a cellular substrate. Hence, potentially this agent represents a valuable stepping stone for the development of novel therapeutics against Yersinia infections. The data reported further demonstrate the utility of the HTS by NMR approach in deriving novel peptide mimetics targeting protein-protein interactions. PMID:26592695

  3. Ionosphere scintillations associated with features of equatorial ionosphere

    NASA Technical Reports Server (NTRS)

    Chandra, H.; Vats, H. O.; Sethia, G.; Deshpande, M. R.; Rastogi, R. G.; Sastri, J. H.; Murthy, B. S.

    1979-01-01

    Amplitude scintillations of radio beacons aboard the ATS-6 satellite on 40 MHz, 140 MHz and 360 MHz recorded during the ATS-6 phase II at an equatorial station Ootacamund (dip 4 deg N) and the ionograms at a nearby station Kodaikanal (dip 3.5 deg N) are examined for scintillation activity. Only sporadic E events, other than Es-q, Es-c or normal E are found to be associated with intense daytime scintillations. Scintillations are also observed during night Es conditions. The amplitude spread is associated with strong scintillations on all frequencies while frequency spread causes weaker scintillations and that mainly at 40 MHz.

  4. Scintillating quantum dots for imaging x-rays (SQDIX) for aircraft inspection

    NASA Astrophysics Data System (ADS)

    Burke, E. R.; DeHaven, S. L.; Williams, P. A.

    2016-02-01

    Scintillation is the process currently employed by conventional X-ray detectors to create X-ray images. Scintillating quantum dots (StQDs) or nano-crystals are novel, nanometer-scale materials that upon excitation by X-rays, re-emit the absorbed energy as visible light. StQDs theoretically have higher output efficiency than conventional scintillating materials and are more environmentally friendly. This paper will present the characterization of several critical elements in the use of StQDs that have been performed along a path to the use of this technology in wide spread X-ray imaging. Initial work on the scintillating quantum dots for imaging X-rays (SQDIX) system has shown great promise to create state-of-the-art sensors using StQDs as a sensor material. In addition, this work also demonstrates a high degree of promise using StQDs in microstructured fiber optics. Using the microstructured fiber as a light guide could greatly increase the capture efficiency of a StQDs based imaging sensor.

  5. Efficiency and timing resolution of scintillator tiles read out with silicon photomultipliers

    NASA Astrophysics Data System (ADS)

    Pooth, O.; Weingarten, S.; Weinstock, L.

    2016-01-01

    Silicon photomultipliers (SiPM) are semiconductor photo sensors that have the potential to replace photomultiplier tubes (PMT) in various fields of application. We present detectors consisting of 30 × 30 × 0.5 cm3 fast plastic scintillator tiles read out with SiPMs. The detectors offer great electronic and mechanical advantages over the classical PMT-scintillator combination. SiPMs are very compact devices that run independent of magnetic fields at low voltages and no light guides between the scintillator and the SiPM are necessary in the presented layouts. Three prototypes, two of which with integrated wavelength shifting fibres, have been tested in a proton beam at the COSY accelerator at Forschungszentrum Jülich. The different layouts are compared in terms of most probable pulse height, detection efficiency and noise behaviour as well as timing resolution. The spatial distributions of these properties across the scintillator surface are presented. The best layout can be operated at a mean efficiency of bar epsilon=99.9 % while sustaining low noise rates in the order of 10 Hz with a timing resolution of less than 3 ns. Both efficiency and timing resolution show good spatial homogeneity.

  6. Screening for Drug-Induced Hepatotoxicity in Primary Mouse Hepatocytes Using Acetaminophen, Amiodarone, and Cyclosporin A as Model Compounds: An Omics-Guided Approach

    PubMed Central

    Van Summeren, Anke; Renes, Johan; Lizarraga, Daneida; Bouwman, Freek G.; Noben, Jean-Paul; van Delft, Joost H. M.; Kleinjans, Jos C. S.

    2013-01-01

    Abstract Drug-induced hepatotoxicity is a leading cause of attrition for candidate pharmaceuticals in development. New preclinical screening methods are crucial to predict drug toxicity prior to human studies. Of all in vitro hepatotoxicity models, primary human hepatocytes are considered as ‘the gold standard.’ However, their use is hindered by limited availability and inter-individual variation. These barriers may be overcome by using primary mouse hepatocytes. We used differential in gel electrophoresis (DIGE) to study large-scale protein expression of primary mouse hepatocytes. These hepatocytes were exposed to three well-defined hepatotoxicants: acetaminophen, amiodarone, and cyclosporin A. Each hepatotoxicant induces a different hepatotoxic phenotype. Based on the DIGE results, the mRNA expression levels of deregulated proteins from cyclosporin A-treated cells were also analyzed. We were able to distinguish cyclosporin A from controls, as well as acetaminophen and amiodarone-treated samples. Cyclosporin A induced endoplasmic reticulum (ER) stress and altered the ER-Golgi transport. Moreover, liver carboxylesterase and bile salt sulfotransferase were differentially expressed. These proteins were associated with a protective adaptive response against cyclosporin A-induced cholestasis. The results of this study are comparable with effects in HepG2 cells. Therefore, we suggest both models can be used to analyze the cholestatic properties of cyclosporin A. Furthermore, this study showed a conserved response between primary mouse hepatocytes and HepG2 cells. These findings collectively lend support for use of omics strategies in preclinical toxicology, and might inform future efforts to better link preclinical and clinical research in rational drug development. PMID:23308384

  7. A compact, in vivo screen of all 6-mers reveals drivers of tissue-specific expression and guides synthetic regulatory element design

    PubMed Central

    2013-01-01

    Background Large-scale annotation efforts have improved our ability to coarsely predict regulatory elements throughout vertebrate genomes. However, it is unclear how complex spatiotemporal patterns of gene expression driven by these elements emerge from the activity of short, transcription factor binding sequences. Results We describe a comprehensive promoter extension assay in which the regulatory potential of all 6 base-pair (bp) sequences was tested in the context of a minimal promoter. To enable this large-scale screen, we developed algorithms that use a reverse-complement aware decomposition of the de Bruijn graph to design a library of DNA oligomers incorporating every 6-bp sequence exactly once. Our library multiplexes all 4,096 unique 6-mers into 184 double-stranded 15-bp oligomers, which is sufficiently compact for in vivo testing. We injected each multiplexed construct into zebrafish embryos and scored GFP expression in 15 tissues at two developmental time points. Twenty-seven constructs produced consistent expression patterns, with the majority doing so in only one tissue. Functional sequences are enriched near biologically relevant genes, match motifs for developmental transcription factors, and are required for enhancer activity. By concatenating tissue-specific functional sequences, we generated completely synthetic enhancers for the notochord, epidermis, spinal cord, forebrain and otic lateral line, and show that short regulatory sequences do not always function modularly. Conclusions This work introduces a unique in vivo catalog of short, functional regulatory sequences and demonstrates several important principles of regulatory element organization. Furthermore, we provide resources for designing compact, reverse-complement aware k-mer libraries. PMID:23867016

  8. Equatorial scintillation model. Technical report, 1 February 1983-30 April 1985

    SciTech Connect

    Fremouw, E.J.; Robins, R.E.

    1985-09-30

    Radiowave scintillation in the presence of natural and/or high-altitude nuclear disturbances has the potential to disrupt numerous transionospheric radio and radar systems. This report develops a model characterizing the plasma-density irregularities that produce scintillation in the naturally disturbed equatorial F layer. The model is incorporated into Program WBMOD along with subroutines for computing both link geometry and scintillation indices, the latter by means of phase screen diffraction theory. The model is based on similarly extensive analysis of wideband data from two equatorial stations. It describes irregularities at an effective height of 350 km that are isotropic across the geomagnetic field and elongated by a factor of 50 along the field and whose one-dimensional spatial power spectrum obeys a single-regime power law with a (negative) spectral index of 1.5. The height-integrated spectral strength of the irregularities is modeled as a function of solar epoch (sunspot number), the angle between the sunset terminator and the geomagnetic field line through the equatorial F layer point in question (a measure of seasonal and longitudinal variation), time after E-layer sunset on that field line, and the F-layer magnetic apex latitude of the point. The report also highlights a factor missing from complete characterization of the joint seasonal/longitudinal variation of scintillation, thought to depend upon thermospheric neutral winds.

  9. Mid-latitude scintillation model. Technical report, 1 November 1985-31 October 1986

    SciTech Connect

    Robins, R.E.; Secan, J.A.; Fremouw, E.J.

    1986-10-31

    Radiowave scintillation in the presence of ionospheric disturbances has the potential to disrupt numerous transionospheric radio and radar systems. This report describes development of a model characterizing the plasma density irregularities that produce scintillation in the naturally disturbed mid-latitude F layer. The model will be incorporated into Program WBMOD, which includes subroutines for computing both link geometry and scintillation indices, the latter by means of phase screen diffraction theory. Earlier versions of WBMOD, were based on extensive analysis of scintillation data collected in the auroral and equatorial zones in Wideband Satellite Mission. The model described herein is based on similarly extensive analysis of Wideband data from one mid latitude station and of data collected from HiLat satellite at another mid latitude station. The model describes irregularities at an effective height of 350 km that are isotropic across the geomagnetic field and elongated by a factor of 10 along the field and whose one-dimensional spatial power spectrum obeys a single regime power law with a (negative) spectral index of 1.5. The height-integrated spectral strength of the irregularities is modeled as a function apex latitude of the point. The report highlights a disagreement by a factor of approximately three between irregularity strength inferred from the two satellites in a region of overlap between the two mid-latitude stations.

  10. Chemical compatibility screening test results

    SciTech Connect

    Nigrey, P.J.; Dickens, T.G.

    1997-12-01

    A program for evaluating packaging components that may be used in transporting mixed-waste forms has been developed and the first phase has been completed. This effort involved the screening of ten plastic materials in four simulant mixed-waste types. These plastics were butadiene-acrylonitrile copolymer rubber, cross-linked polyethylene (XLPE), epichlorohydrin rubber, ethylene-propylene rubber (EPDM), fluorocarbon (Viton or Kel-F), polytetrafluoroethylene, high-density polyethylene (HDPE), isobutylene-isoprene copolymer rubber (butyl), polypropylene, and styrene-butadiene rubber (SBR). The selected simulant mixed wastes were (1) an aqueous alkaline mixture of sodium nitrate and sodium nitrite; (2) a chlorinated hydrocarbon mixture; (3) a simulant liquid scintillation fluid; and (4) a mixture of ketones. The testing protocol involved exposing the respective materials to 286,000 rads of gamma radiation followed by 14-day exposures to the waste types at 60{degrees}C. The seal materials were tested using vapor transport rate (VTR) measurements while the liner materials were tested using specific gravity as a metric. For these tests, a screening criterion of 0.9 g/hr/m{sup 2} for VTR and a specific gravity change of 10% was used. Based on this work, it was concluded that while all seal materials passed exposure to the aqueous simulant mixed waste, EPDM and SBR had the lowest VTRs. In the chlorinated hydrocarbon simulant mixed waste, only Viton passed the screening tests. In both the simulant scintillation fluid mixed waste and the ketone mixture simulant mixed waste, none of the seal materials met the screening criteria. For specific gravity testing of liner materials, the data showed that while all materials with the exception of polypropylene passed the screening criteria, Kel-F, HDPE, and XLPE offered the greatest resistance to the combination of radiation and chemicals.

  11. Review on photonic crystal coatings for scintillators

    NASA Astrophysics Data System (ADS)

    Knapitsch, Arno; Lecoq, Paul

    2014-11-01

    The amount of light and its time distribution are key factors determining the performance of scintillators when used as radiation detectors. However most inorganic scintillators are made of heavy materials and suffer from a high index of refraction which limits light extraction efficiency. This increases the path length of the photons in the material with the consequence of higher absorption and tails in the time distribution of the extracted light. Photonic crystals are a relatively new way of conquering this light extraction problem. Basically they are a way to produce a smooth and controllable index matching between the scintillator and the output medium through the nanostructuration of a thin layer of optically transparent high index material deposited at the coupling face of the scintillator. Our review paper discusses the theory behind this approach as well as the simulation details. Furthermore the different lithography steps of the production of an actual photonic crystal sample will be explained. Measurement results of LSO scintillator pixels covered with a nanolithography machined photonic crystal surface are presented together with practical tips for the further development and improvement of this technique.

  12. Radar detection during scintillation. Technical report

    SciTech Connect

    Knepp, D.L.; Reinking, J.T.

    1990-04-01

    Electromagnetic signals that propagate through a disturbed region of the ionosphere can experience scattering which can cause fluctuations in the received amplitude, phase, and angle-of-arrival. This report considers the performance of a radar that must operate through a disturbed propagation environment such as might occur during strong equatorial scintillation, during a barium release experiment or after a high altitude nuclear detonation. The severity of the channel disturbance is taken to range from weak scattering where the signal quadrature components are uncorrelated Gaussian variates. The detection performance of noncoherent combining is compared to that of double threshold (M out of N) combining under various levels of scintillation disturbance. Results are given for detection sensitivity as a function of the scintillation index and the ratio of the radar hopping bandwidth to the channel bandwidth. It is shown that both types of combining can provide mitigation of fading, and that noncoherent combining generally enjoys an advantage in detection sensitivity of about 2 dB. This work serves as a quantitative guideline to the advantages and disadvantages of certain types of detection strategies during scintillation and is, therefore, useful in the radar design process. However, a detailed simulation of the radar detection algorithms is necessary to evaluate a radar design strategy to predict performance under scintillation conditions.

  13. Thallium bromide photodetectors for scintillation detection

    NASA Astrophysics Data System (ADS)

    Hitomi, K.; Muroi, O.; Shoji, T.; Hiratate, Y.; Ishibashi, H.; Ishii, M.

    2000-07-01

    A wide bandgap compound semiconductor, TlBr, has been investigated as a blue sensitive photodetector material for scintillation detection. The TlBr photodetectors have been fabricated from the TlBr crystals grown by the TMZ method using materials purified by many pass zone refining. The performance of the photodetectors has been evaluated by measuring their leakage current, quantum efficiency, spatial uniformity, direct X-ray detection and scintillation detection characteristics. The photodetectors have shown high quantum efficiency for the blue wavelength region and high spatial uniformity for their optical response. In addition, good direct X-ray detection characteristics with an energy resolution of 4.5 keV FWHM for 22 keV X-rays from a 109Cd radioactive source have been obtained. Detection of blue scintillation from GSO and LSO scintillators irradiated with a 22Na radioactive source has been done successfully by using the photodetectors at room temperature. A clear full-energy peak for 511 keV γ-rays has been obtained with the TlBr photodetector coupled to the LSO scintillator with an energy resolution of 40% FWHM.

  14. Simulation of optical configurations and signal processing methods in Anger-type neutron-position scintillation detector

    NASA Astrophysics Data System (ADS)

    Roche, C. T.; Strauss, M. G.; Brenner, R.

    The spatial linearity and resolution of Anger type neutron position scintillation detectors were studied as a semi-empirical model. Detector optics with either an air gap or optical grease between the scintillator and the dispersive light guide are considered. Three signal processing methods which truncate signals from PMT's distant from the scintillation are compared with the linear resistive weighting method. Air gap optics yields a 15% improvement in spatial resolution and 50% reduction in differential and integral nonlinearity relative to grease coupled optics, using linear processing. Using signal truncation instead of linear processing improves the resolution 15% to 20% for the air gap and 20% to 30% for the grease coupling case. The initial discrepancy in the resolution between the two optics nearly vanished, however, the linearity of the grease coupled system is still significantly poorer.

  15. Simulation of optical configurations and signal processing methods in Anger-type neutron-position scintillation detector

    SciTech Connect

    Roche, C.T.; Strauss, M.G.; Brenner, R.

    1984-01-01

    The spatial linearity and resolution of Anger-type neutron-position scintillation detectors are studied using a semi-empirical model. Detector optics with either an air gap or optical grease between the scintillator and the dispersive light guide are considered. Three signal processing methods which truncate signals from PMT's distant from the scintillation are compared with the linear resistive weighting method. Air gap optics yields a 15% improvement in spatial resolution and 50% reduction in differential and integral nonlinearity relative to grease coupled optics, using linear processing. Using signal truncation instead of linear processing improves the resolution 15-20% for the air gap and 20-30% for the grease coupling case. Thus, the initial discrepancy in the resolution between the two optics nearly vanished, however the linearity of the grease coupled system is still significantly poorer.

  16. Airport Screening

    MedlinePlus

    ... 2011 Photo courtesy of Dan Paluska/Flickr Denver Airport Security Screening Introduction With air travel regaining popularity and increased secu- rity measures, airport security screening has become an area of interest for ...

  17. Health Screening

    MedlinePlus

    Screenings are tests that look for diseases before you have symptoms. Screening tests can find diseases early, when they're easier ... Overweight and obesity Prostate cancer in men Which tests you need depends on your age, your sex, ...

  18. MRSA Screening

    MedlinePlus

    ... be limited. Home Visit Global Sites Search Help? MRSA Screening Share this page: Was this page helpful? Formal name: Methicillin resistant Staphylococcus aureus Screening Related tests: Wound Culture At a Glance ...

  19. Characterization of ionospheric scintillation at a geomagnetic equatorial region station

    NASA Astrophysics Data System (ADS)

    Seba, Ephrem Beshir; Gogie, Tsegaye Kassa

    2015-11-01

    In this study, we analyzed ionospheric scintillation at Bahir Dar station, Ethiopia (11.6°N, 37.38°E) using GPS-SCINDA data between August 2010 and July 2011. We found that small scale variation in TEC caused high ionospheric scintillation, rather than large scale variation. We studied the daily and monthly variations in the scintillation index S4 during this year, which showed that scintillation was a post-sunset phenomenon on equinoctial days, with high activity during the March equinox. The scintillation activity observed on solstice days was relatively low and almost constant throughout the day with low post-sunset activity levels. Our analysis of the seasonal and annual scintillation characteristics showed that intense activity occurred in March and April. We also studied the dependence of the scintillation index on the satellite elevation angle and found that scintillation was high for low angles but low for high elevation angles.

  20. Isotopic response with small scintillator based gamma-ray spectrometers

    DOEpatents

    Madden, Norman W.; Goulding, Frederick S.; Asztalos, Stephen J.

    2012-01-24

    The intrinsic background of a gamma ray spectrometer is significantly reduced by surrounding the scintillator with a second scintillator. This second (external) scintillator surrounds the first scintillator and has an opening of approximately the same diameter as the smaller central scintillator in the forward direction. The second scintillator is selected to have a higher atomic number, and thus has a larger probability for a Compton scattering interaction than within the inner region. Scattering events that are essentially simultaneous in coincidence to the first and second scintillators, from an electronics perspective, are precluded electronically from the data stream. Thus, only gamma-rays that are wholly contained in the smaller central scintillator are used for analytic purposes.

  1. Scintillating-glass-fiber neutron sensors

    NASA Astrophysics Data System (ADS)

    Abel, K. H.; Arthur, R. J.; Bliss, M.; Brite, D. W.; Brodzinski, R. L.; Craig, R. A.; Geelhood, B. D.; Goldman, D. S.; Griffin, J. W.; Perkins, R. W.; Reeder, P. L.; Richey, W. R.; Stahl, K. A.; Sunberg, D. S.; Warner, R. A.; Wogman, N. A.; Weber, M. J.

    1994-12-01

    Cerium-doped lithium-silicate glass fibers have been developed at Pacific Northwest Laboratory (PNL) for use as thermal neutron detectors. By using highly-enriched 6Li, these fibers efficiently capture thermal neutrons and produce scintillation light that can be detected at the ends of the fibers. Advantages of scintillating fibers over 3He or BF 3 proportional tubes include flexibility in geometric configuration, ruggedness in high-vibration environments, and less detector weight for the same neutron sensitivity. This paper describes the performance of these scintillating fibers with regard to count rates, pulse height spectra, absolute efficiencies, and neutron/gamma discrimination. Fibers with light transmission lengths ( {1}/{e}) of greater than 2 m have been produced at PNL. Neutron sensors in fiber form allow development of a variety of neutron detectors packaged in previously unavailable configurations. Brief descriptions of some of the devices already produced are included to illustrate these possibilities.

  2. Bispectral analysis of meter wavelength interplanetary scintillation

    NASA Technical Reports Server (NTRS)

    Armstrong, J. W.

    1977-01-01

    The bispectrum of interplanetary scintillation is investigated. Rice-squared and lognormal point-source intensity probability density functions are used to derive model bispectra as functionals of the intensity autocovariance. Simultaneous observations of the source CTA 21 at 270, 340, and 470 MHz are analyzed to produce scintillation indices, skewness parameters, and bispectra, which are compared with the models for the cases of weak, intermediate, and strong scattering. The results obtained for CTA 21 are shown to rule out lognormal statistics for interplanetary scintillation over the frequency range from 340 to 470 MHz. It is found that the observed bispectra correspond well with the predictions of the Rice-squared model for weak and intermediate scattering, but are systematically different from model bispectra computed by assuming a point source in the case of strong scattering.

  3. Wavelength-shifter Readout of Scintillation Counters

    NASA Astrophysics Data System (ADS)

    Pauletta, Giovanni

    1998-04-01

    A compact system for reading out the scintillation counters of the CDF muon upgrade has been developed and tested. The system relies on wavelength-shifter (wls) fiber ribbon, glued to the side of 1.5 to 2 cm - thick counters, to collect and transfer the light from the scintillator to a small(Hamamatsu R5600) phototube, embedded in one corner of the counter. Prototype counters were constructed from polystyrene-based scintillator(Manufactured by Monocristal Institute at Kharkov under Dubna supervision.) using y11 - doped wls fibers(Manufactured by Kuraray.) for readout. Their response to cosmic ray muons was measured and found to be adequate for up to more than 3 m when the light collection was enhanced by mirroring the wls fiber ends furthest from the photomultiplier.

  4. New Efficient Organic Scintillators Derived from Pyrazoline.

    PubMed

    Bliznyuk, Valery N; Seliman, Ayman F; Ishchenko, Alexander A; Derevyanko, Nadezhda A; DeVol, Timothy A

    2016-05-25

    We report on the synthesis, spectroscopic and scintillation properties of three new pyrazoline core based fluorophores. Fluorescence properties of the fluorophores have been studied both in a solution state and in a solid polyvinyltoluene (PVT) resin matrix of different porosity. The synthesized fluorophores were found to be promising candidates for application in plastic scintillators for detection of ionizing radiation (alpha, beta particles, γ rays and neutrons) and demonstrated superior efficiency in comparison to the existing commercially used fluorophores (2-(1-naphthyl)-5-phenyloxazole (αNPO), 9,10-diphenylanthracene, etc.). Moreover, the suggested synthetic route allows functionalization of the fluorophores with a vinyl group for further covalent bound to the PVT or other vinyl polymer matrices, which dramatically improves chemical stability of the system simultaneously improving the photoluminescence quantum yield. Possible mechanisms of the enhanced scintillation properties are discussed based on preliminary quantum mechanical calculations and spectroscopic characteristics of the fluorophores under study. PMID:27163887

  5. Refractive scintillation in the interstellar medium

    NASA Astrophysics Data System (ADS)

    Coles, W. A.; Rickett, B. J.; Codona, J. L.; Frehlich, R. G.

    1987-04-01

    The slow variation in the apparent intensity of pulsars on time scales of days to months was recently shown to be due to a large-scale component of interstellar scintillation (Rickett, Coles, and Bourgois). These variations are greater than one would expect if the turbulence spectrum were a simple Kolmogorov power law. It is shown that this large-scale component can be greatly enhanced when the turbulence spectrum has a limiting "inner scale" of the order of 109m. The authors present a solution for the covariance of refractive scintillation of an extended source in an extended medium. The results show that refractive scintillations are also responsible for slow variations in "low-frequency variables".

  6. Testing Gravity Using Pulsar Scintillation Measurements

    NASA Astrophysics Data System (ADS)

    Yang, Huan; Nishizawa, Atsushi; Pen, Ue-Li

    2016-03-01

    We propose to use pulsar scintillation measurements to test predictions of alternative theories of gravity. Comparing to single-path pulsar timing measurements, the scintillation measurements can achieve a factor of 104 ~105 improvement in timing accuracy, due to the effect of multi-path interference. The self-noise from pulsar also does not affect the interference pattern, where the data acquisition timescale is 103 seconds instead of years. Therefore it has unique advantages in measuring gravitational effect or other mechanisms (at mHz and above frequencies) on light propagation. We illustrate its application in constraining scalar gravitational-wave background and measuring gravitational-wave speed, in which cases the sensitivities are greatly improved with respect to previous limits. We expect much broader applications in testing gravity with existing and future pulsar scintillation observations.

  7. The design of the TASD (totally active scintillator detector) prototype

    SciTech Connect

    Mefodiev, A. V. Kudenko, Yu. G.

    2015-12-15

    Totally active and magnetic segmented scintillation neutrino detectors are developed for the nextgeneration accelerator neutrino experiments. Such detectors will incorporate scintillation modules with scintillation counters that form X and Y planes. A single counter is a 7 × 10 × 90 mm{sup 3} scintillation bar with gluedin wavelength-shifting fibers and micropixel avalanche photodiodes. The results of measurements of the parameters of these detectors are presented.

  8. Spectral attenuation length of scintillating fibers

    NASA Astrophysics Data System (ADS)

    Drexlin, Guido; Eberhard, Veit; Hunkel, Dirk; Zeitnitz, B.

    1995-02-01

    A double spectrometer allows the precise measurement of the spectral attenuation length of scintillating fibers. Exciting the fibers with a N 2-laser at different points and measuring the wavelength dependent light intensity on both ends of the fiber simultaneously, enables a measurement of the attenuation length which is practically independent of systematic uncertainties. The experimental setup can additionally be used for the measurement of the relative light output. Six types of scintillating fibers from four manufactures (Bicron, Kuraray, Pol.Hi.Tech, and Plastifo) were tested. For different fibers the wavelength dependent attenuation lengths were measured from 0.3 m up to 20 m with an accuracy as good as 1%.

  9. Near-infrared scintillation of liquid argon

    NASA Astrophysics Data System (ADS)

    Alexander, T.; Escobar, C. O.; Lippincott, W. H.; Rubinov, P.

    2016-03-01

    Since the 1970s it has been known that noble gases scintillate in the near infrared (NIR) region of the spectrum (0.7 μm < λ < 1.5 μm). More controversial has been the question of the NIR light yield for condensed noble gases. We first present the motivation for using the NIR scintillation in liquid argon detectors, then briefly review early as well as more recent efforts and finally show encouraging preliminary results of a test performed at Fermilab.

  10. Statistics of time averaged atmospheric scintillation

    SciTech Connect

    Stroud, P.

    1994-02-01

    A formulation has been constructed to recover the statistics of the moving average of the scintillation Strehl from a discrete set of measurements. A program of airborne atmospheric propagation measurements was analyzed to find the correlation function of the relative intensity over displaced propagation paths. The variance in continuous moving averages of the relative intensity was then found in terms of the correlation functions. An empirical formulation of the variance of the continuous moving average of the scintillation Strehl has been constructed. The resulting characterization of the variance of the finite time averaged Strehl ratios is being used to assess the performance of an airborne laser system.

  11. The homestake surface-underground scintillations: Description

    NASA Technical Reports Server (NTRS)

    Cherry, M. L.; Corbato, S.; Daily, T.; Fenyves, E. J.; Kieda, D.; Lande, K.; Lee, C. K.

    1985-01-01

    Two new detectors are currently under construction at the Homestake Gold Mine a 140-ton Large Area Scintillation Detector (LASD) with an upper surface area of 130 square meters, a geometry factor (for an isotropic flux) of 1200 square meters, sr, and a depth of 4200 m.w.e.; and a surface air shower array consisting of 100 scintillator elements, each 3 square meters, spanning an area of approximately square kilometers. Underground, half of the LASD is currently running and collecting muon data; on the surface, the first section of the air shower array will begin operation in the spring of 1985. The detectors and their capabilities are described.

  12. Scintillation index in strong oceanic turbulence

    NASA Astrophysics Data System (ADS)

    Baykal, Yahya

    2016-09-01

    Scintillation index of spherical wave in strongly turbulent oceanic medium is evaluated. In the evaluation, modified Rytov solution and our recent formulation that expresses the oceanic turbulence parameters by the atmospheric turbulence structure constant, are employed. Variations of the scintillation index in strong oceanic turbulence are examined versus the oceanic turbulence parameters such as the rate of dissipation of kinetic energy per unit mass of fluid, the rate of dissipation of mean-squared temperature, viscosity, wavelength, the link length, and the ratio of temperature to salinity contributions to the refractive index spectrum.

  13. New Structured Scintillators for Neutron Radiography

    NASA Astrophysics Data System (ADS)

    Nagarkar, V. V.; Ovechkina, E. E.; Bhandari, H. B.; Soundara-Pandian, L.; More, M. J.; Riedel, R. A.; Miller, S. R.

    We report on the development of novel neutron scintillators fabricated in microcolumnar formats using the physical vapour deposition (PVD) method. Such structures mitigate the conventional trade-off between spatial resolution and detection efficiency by channelling the scintillation light towards the detector while minimizing lateral spread in the film. Consequently, high resolution and high contrast neutron images can be acquired in a time efficient manner. In this paper, we discuss methods and characterization for scintillator films made from three distinct compositions, Thallium (Tl) or Europium (Eu) doped Lithium CesiumIodide (Li3Cs2I5:Tl,Eu, referred to as LCI), Tl or Eudoped Lithium Sodium Iodide (LixNa1-xI:Tl,Eu, referred to as LNI), and Cerium (Ce)-doped Gadolinium Iodide (GdI3:Ce, referred to as GDI). LCI and LNI scintillators are derived from the well-known CsI and NaI scintillators by the incorporation of 6Li into their lattice. Based on our measurements reported here, LCI/LNI scintillators have shown to exhibit bright emissions, fast, sub-microsecond decay, and an ability to effectively discriminate between neutron and gamma interactions using pulse shape (PSD) and/or pulse height (PHD) discrimination. LCI has a density of 4.5 g/cm3, a measured peak emission wavelength of 460 nm (doped with Eu), and a light yield of ∼50,000 photons/thermal neutron. LNI has a density of 3.6 g/cm3, an emission peak measured at 420 nm, and a light yield of ∼100,000 photons/thermal neutron. The recently discovered GDI exhibits excellent scintillation properties including a bright emission of up to 5,000 photons/thermal neutron interaction, 550 nm green emission, a rise time of ∼0.5 ns and a primary decay time of ∼38 ns (Glodo et al., 2006). Its high thermal neutron cross-section of ∼255 kb makes it an attractive candidate for neutron detection and imaging. Although it has high density of 5.2 gm/cm3 and effective atomic number of 57, its gamma sensitivity can be

  14. 21 CFR 892.1100 - Scintillation (gamma) camera.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Scintillation (gamma) camera. 892.1100 Section 892.1100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1100 Scintillation (gamma) camera. (a) Identification. A scintillation (gamma) camera...

  15. Upconverting nanoparticles for optimizing scintillator based detection systems

    DOEpatents

    Kross, Brian; McKisson, John E; McKisson, John; Weisenberger, Andrew; Xi, Wenze; Zom, Carl

    2013-09-17

    An upconverting device for a scintillation detection system is provided. The detection system comprises a scintillator material, a sensor, a light transmission path between the scintillator material and the sensor, and a plurality of upconverting nanoparticles particles positioned in the light transmission path.

  16. Propagation of Gaussian beams through a modified von Karman phase screen

    NASA Astrophysics Data System (ADS)

    Whitfield, Erica M.; Banerjee, Partha P.; Haus, Joseph W.

    2012-10-01

    Gaussian beam propagation through a thin screen and an extended random media has been studied using a beam propagation method. We use the modified von Karman spectrum model to describe the phase screen statistics. The scintillation index is analyzed as a function of the structure constant, phase screen location, the initial width and curvature of the Gaussian beam, etc. The numerical simulations are extended using a pair of Gaussian beams. We examine the interference of the beams and measure the fringe visibility at the target. The results are correlated with the scintillation index.

  17. Simulation tool for optical design of PET detector modules including scintillator material and sensor array

    SciTech Connect

    Jatekos, B.; Erdei, G.; Lorincz, E.

    2011-07-01

    The appearance of single photon avalanche diodes (SPADs) in the field of PET detector modules made it necessary to apply more complex optical design methods to refine the performance of such assemblies. We developed a combined simulation tool that is capable to model complex detector structures including scintillation material, light guide, light collection optics and sensor, correctly taking into account the statistical behavior of emission of scintillation light and its absorbance in SPADs. As a validation we compared simulation results obtained by our software and another optical design program. Calculations were performed for a simple PET detector arrangement used for testing purposes. According to the results, deviation of center of gravity coordinates between the two simulations is 0.0195 mm, the average ratio of total counts 1.0052. We investigated the error resulting from finite sampling in wavelength space and we found that 20 nm pitch is sufficient for the simulation in case of the given spectral dependencies. (authors)

  18. Clinical prototype of a plastic water-equivalent scintillating fiber dosimeter array for QA applications

    SciTech Connect

    Lacroix, Frederic; Archambault, Louis; Gingras, Luc; Guillot, Mathieu; Beddar, A. Sam; Beaulieu, Luc

    2008-08-15

    A clinical prototype of a scintillating fiber dosimeter array for quality assurance applications is presented. The array consists of a linear array of 29 plastic scintillation detectors embedded in a water-equivalent plastic sheet coupled to optical fibers used to guide optical photons to a charge coupled device (CCD) camera. The CCD is packaged in a light-tight, radiation-shielded housing designed for convenient transport. A custom designed connector is used to ensure reproducible mechanical positioning of the optical fibers relative to the CCD. Profile and depth dose characterization measurements are presented and show that the prototype provides excellent dose measurement reproducibility ({+-}0.8%) in-field and good accuracy ({+-}1.6% maximum deviation) relative to the dose measured with an IC10 ionization chamber.

  19. Double screening

    NASA Astrophysics Data System (ADS)

    Gratia, Pierre; Hu, Wayne; Joyce, Austin; Ribeiro, Raquel H.

    2016-06-01

    Attempts to modify gravity in the infrared typically require a screening mechanism to ensure consistency with local tests of gravity. These screening mechanisms fit into three broad classes; we investigate theories which are capable of exhibiting more than one type of screening. Specifically, we focus on a simple model which exhibits both Vainshtein and kinetic screening. We point out that due to the two characteristic length scales in the problem, the type of screening that dominates depends on the mass of the sourcing object, allowing for different phenomenology at different scales. We consider embedding this double screening phenomenology in a broader cosmological scenario and show that the simplest examples that exhibit double screening are radiatively stable.

  20. Monte Carlo investigations of the effect of beam divergence on thick, segmented crystalline scintillators for radiotherapy imaging

    PubMed Central

    Wang, Yi; El-Mohri, Youcef; Antonuk, Larry E.; Zhao, Qihua

    2010-01-01

    The use of thick segmented scintillators in electronic portal imagers offers the potential for significant improvement in x-ray detection efficiency compared to conventional phosphor screens. Such improvement substantially increases the detective quantum efficiency (DQE), leading to the possibility of achieving soft-tissue visualization at clinically-practical (i.e. low) doses using megavoltage (MV) cone-beam computed tomography. While these DQE increases are greatest at zero spatial frequency, they are diminished at higher frequencies as a result of degradation of spatial resolution due to lateral spreading of secondary radiation within the scintillator – an effect that is more pronounced for thicker scintillators. The extent of this spreading is even more accentuated for radiation impinging the scintillator at oblique angles of incidence due to beam divergence. In this paper, Monte Carlo simulations of radiation transport, performed to investigate and quantify the effects of beam divergence on the imaging performance of MV imagers based on two promising scintillators (BGO and CsI:T1), are reported. In these studies, 10 – 40 mm thick scintillators, incorporating low-density polymer, or high-density tungsten septal walls were examined for incident angles corresponding to that encountered at locations up to ~15 cm from the central beam axis (for an imager located 130 cm from a radiotherapy x-ray source). The simulations demonstrate progressively more severe spatial resolution degradation (quantified in terms of the effect on modulation transfer function) as a function of increasing angle of incidence (as well as of scintillator thickness). Since the noise power behavior was found to be largely independent of incident angle, the dependence of the DQE on incident angle is therefore primarily determined by the spatial resolution. The observed DQE degradation suggests that 10 mm thick scintillators are not strongly affected by beam divergence for detector areas up

  1. Optimization of the design of thick, segmented scintillators for megavoltage cone-beam CT using a novel, hybrid modeling technique

    PubMed Central

    Liu, Langechuan; Antonuk, Larry E.; El-Mohri, Youcef; Zhao, Qihua; Jiang, Hao

    2014-01-01

    Purpose: Active matrix flat-panel imagers (AMFPIs) incorporating thick, segmented scintillators have demonstrated order-of-magnitude improvements in detective quantum efficiency (DQE) at radiotherapy energies compared to systems based on conventional phosphor screens. Such improved DQE values facilitate megavoltage cone-beam CT (MV CBCT) imaging at clinically practical doses. However, the MV CBCT performance of such AMFPIs is highly dependent on the design parameters of the scintillators. In this paper, optimization of the design of segmented scintillators was explored using a hybrid modeling technique which encompasses both radiation and optical effects. Methods: Imaging performance in terms of the contrast-to-noise ratio (CNR) and spatial resolution of various hypothetical scintillator designs was examined through a hybrid technique involving Monte Carlo simulation of radiation transport in combination with simulation of optical gain distributions and optical point spread functions. The optical simulations employed optical parameters extracted from a best fit to measurement results reported in a previous investigation of a 1.13 cm thick, 1016 μm pitch prototype BGO segmented scintillator. All hypothetical designs employed BGO material with a thickness and element-to-element pitch ranging from 0.5 to 6 cm and from 0.508 to 1.524 mm, respectively. In the CNR study, for each design, full tomographic scans of a contrast phantom incorporating various soft-tissue inserts were simulated at a total dose of 4 cGy. Results: Theoretical values for contrast, noise, and CNR were found to be in close agreement with empirical results from the BGO prototype, strongly supporting the validity of the modeling technique. CNR and spatial resolution for the various scintillator designs demonstrate complex behavior as scintillator thickness and element pitch are varied—with a clear trade-off between these two imaging metrics up to a thickness of ∼3 cm. Based on these results, an

  2. Robust GPS carrier tracking under ionospheric scintillation

    NASA Astrophysics Data System (ADS)

    Susi, M.; Andreotti, M.; Aquino, M. H.; Dodson, A.

    2013-12-01

    Small scale irregularities present in the ionosphere can induce fast and unpredictable fluctuations of Radio Frequency (RF) signal phase and amplitude. This phenomenon, known as scintillation, can degrade the performance of a GPS receiver leading to cycle slips, increasing the tracking error and also producing a complete loss of lock. In the most severe scenarios, if the tracking of multiple satellites links is prevented, outages in the GPS service can also occur. In order to render a GPS receiver more robust under scintillation, particular attention should be dedicated to the design of the carrier tracking stage, that is the receiver's part most sensitive to these types of phenomenon. This paper exploits the reconfigurability and flexibility of a GPS software receiver to develop a tracking algorithm that is more robust under ionospheric scintillation. For this purpose, first of all, the scintillation level is monitored in real time. Indeed the carrier phase and the post correlation terms obtained by the PLL (Phase Locked Loop) are used to estimate phi60 and S4 [1], the scintillation indices traditionally used to quantify the level of phase and amplitude scintillations, as well as p and T, the spectral parameters of the fluctuations PSD. The effectiveness of the scintillation parameter computation is confirmed by comparing the values obtained by the software receiver and the ones provided by a commercial scintillation monitoring, i.e. the Septentrio PolarxS receiver [2]. Then the above scintillation parameters and the signal carrier to noise density are exploited to tune the carrier tracking algorithm. In case of very weak signals the FLL (Frequency Locked Loop) scheme is selected in order to maintain the signal lock. Otherwise an adaptive bandwidth Phase Locked Loop (PLL) scheme is adopted. The optimum bandwidth for the specific scintillation scenario is evaluated in real time by exploiting the Conker formula [1] for the tracking jitter estimation. The performance

  3. Detection of charged particles and X-rays by scintillator layers coupled to amorphous silicon photodiode arrays

    SciTech Connect

    Jing, T.; Drewery, J.; Hong, W.S.; Lee, H.; Kaplan, S.N.; Perez-Mendez, V.; Goodman, C.A.; Wildermuth, D.

    1995-04-01

    Hydrogenated amorphous silicon (a-Si:H) p-i-n diodes with transparent metallic contacts are shown to be suitable for detecting charged particles, electrons, and X-rays. When coupled to a suitable scintillator using CsI(Tl) as the scintillator we show a capability to detect minimum ionizing particles with S/N {approximately}20. We demonstrate such an arrangement by operating a p-i-n diode in photovoltaic mode (reverse bias). Moreover, we show that a p-i-n diode can also work as a photoconductor under forward bias and produces a gain yield of 3-8 higher light sensitivity for shaping times of 1 {mu}s. n-i-n devices have similar optical gain as the p-i-n photoconductor for short integrating times ( < 10{mu}s). However, n-i-n devices exhibit much higher gain for a long term integration (10ms) than the p-i-n ones. High sensitivity photosensors are very desirable for X-ray medical imaging because radiation exposure dose can be reduced significantly. The scintillator CsI layers we made have higher spatial resolution than the Kodak commercial scintillator screens due to their internal columnar structure which can collimate the scintillation light. Evaporated CsI layers are shown to be more resistant to radiation damage than the crystalline bulk CsI(Tl).

  4. The SNO+ Scintillator Purification Plant and Projected Sensitivity to Solar Neutrinos in the Pure Scintillator Phase

    NASA Astrophysics Data System (ADS)

    Pershing, Teal; SNO+ Collaboration

    2016-03-01

    The SNO+ detector is a neutrino and neutrinoless double-beta decay experiment utilizing the renovated SNO detector. In the second phase of operation, the SNO+ detector will contain 780 tons of organic liquid scintillator composed of 2 g/L 2,5-diphenyloxazole (PPO) in linear alkylbenzene (LAB). In this phase, SNO+ will strive to detect solar neutrinos in the sub-MeV range, including CNO production neutrinos and pp production neutrinos. To achieve the necessary detector sensitivity, a four-part scintillator purification plant has been constructed in SNOLAB for the removal of ionic and radioactive impurities. We present an overview of the SNO+ scintillator purification plant stages, including distillation, water extraction, gas stripping, and metal scavenger columns. We also give the projected SNO+ sensitivities to various solar-produced neutrinos based on the scintillator plant's projected purification efficiency.

  5. Development of scintillator plates with high energy resolution for alpha particles made of GPS scintillator grains

    NASA Astrophysics Data System (ADS)

    Shimaoka, Takehiro; Kaneko, Junichi H.; Izaki, Kenji; Tsubota, Youichi; Higuchi, Mikio; Nishiyama, Shusuke

    2014-01-01

    A scintillator plate with high energy resolution was developed to produce an alpha particle monitor used in nuclear fuel reprocessing plants and mixed plutonium-uranium oxide (MOX) fuel plants. Grains of a Gd2Si2O7 (GPS) scintillator of several 10 to 550 μm were fixed on a glass substrate and were then mechanically polished. By increasing the size of scintillator grains and removing fine powders, the collected light yield and energy resolution for alpha particles were drastically improved. Energy resolution of 9.3% was achieved using average grain size of 91 μm. Furthermore, the ratios between counts in a peak and total counts were improved by more than 60% by the further increase of grain size and adoption of mechanically polished surfaces on both sides. Beta and gamma ray influences were suppressed sufficiently by the thin 100 μm scintillator plates.

  6. Screening for Panic Disorder

    MedlinePlus

    ... Membership Journal & Multimedia Resources Awards Consumers Screening for Panic Disorder Main navigation FAQs Screen Yourself Screening for Depression ... Screening for Obsessive-Compulsive Disorder (OCD) Screening for Panic Disorder Screening for Posttraumatic Stress Disorder (PTSD) Screening for ...

  7. Genetic Screening

    PubMed Central

    Burke, Wylie; Tarini, Beth; Press, Nancy A.; Evans, James P.

    2011-01-01

    Current approaches to genetic screening include newborn screening to identify infants who would benefit from early treatment, reproductive genetic screening to assist reproductive decision making, and family history assessment to identify individuals who would benefit from additional prevention measures. Although the traditional goal of screening is to identify early disease or risk in order to implement preventive therapy, genetic screening has always included an atypical element—information relevant to reproductive decisions. New technologies offer increasingly comprehensive identification of genetic conditions and susceptibilities. Tests based on these technologies are generating a different approach to screening that seeks to inform individuals about all of their genetic traits and susceptibilities for purposes that incorporate rapid diagnosis, family planning, and expediting of research, as well as the traditional screening goal of improving prevention. Use of these tests in population screening will increase the challenges already encountered in genetic screening programs, including false-positive and ambiguous test results, overdiagnosis, and incidental findings. Whether this approach is desirable requires further empiric research, but it also requires careful deliberation on the part of all concerned, including genomic researchers, clinicians, public health officials, health care payers, and especially those who will be the recipients of this novel screening approach. PMID:21709145

  8. An improved model of equatorial scintillation

    NASA Astrophysics Data System (ADS)

    Secan, J. A.; Bussey, R. M.; Fremouw, E. J.; Basu, Sa.

    1995-05-01

    One of the main limitations of the modeling work that went into the equatorial section of the Wideband ionospheric scintillation model (WBMOD) was that the data set used in the modeling was limited to two stations near the dip equator (Ancon, Peru, and Kwajalein Island, in the North Pacific Ocean) at two fixed local times (nominally 1000 and 2200). Over the past year this section of the WBMOD model has been replaced by a model developed using data from three additional stations (Ascension Island, in the South Atlantic Ocean, Huancayo, Peru, and Manila, Phillipines; data collected under the auspices of the USAF Phillips Laboratory Geophysics Directorate) which provide a greater diversity in both latitude and longitude, as well as cover the entire day. The new model includes variations with latitude, local time, longitude, season, solar epoch, and geomagnetic activity levels. The way in which the irregularity strength parameter CkL is modeled has also been changed. The new model provides the variation of the full probability distribution function (PDF) of log (CkL) rather than simply the average of log (CkL). This permits the user to specify a threshold on scintillation level, and the model will calculate the percent of the time that scintillation will exceed that level in the user-specified scenario. It will also permit calculation of scintillation levels at a user-specified percentile. A final improvement to the WBMOD model is the implementation of a new theory for calculating S4 on a two-way channel.

  9. Scintillator Development for the PROSPECT Experiment

    NASA Astrophysics Data System (ADS)

    Yeh, Minfang

    2014-03-01

    Doped scintillator is the target material of choice for antineutrino detection as it utilizes the time-delayed coincidence signature of the positron annihilation and neutron capture resulting from the Inverse Beta Decay (IBD) interaction. Additionally, the multiple gamma rays or heavy ions emitted after neutron capture on either Gd or 6Li respectively provide a distinct signal for the identification of antineutrino events and therefore significantly enhance accidental background reduction. The choice of scintillator and dopant depends on the detector requirements and scintillator performance criteria. Both Gd and 6Li doped scintillators have been used in past reactor antineutrino experiments such as Double Chooz, Daya Bay, RENO, and Bugey3 and are currently under investigation by the PROSPECT collaboration. Their properties in terms of light yield, optical transparency, chemical stability and background rejection efficiency using Pulse Shape Discrimination (PSD) will be reported. Research sponsored by the U.S. Department of Energy, Office of Nuclear Physics and Office of High Energy Physics, under contract with Brookhaven National Laboratory-Brookhaven Science Associates.

  10. Fluorescent compounds for plastic scintillation applications

    SciTech Connect

    Pla-Dalmau, A.; Bross, A.D.

    1994-04-01

    Several 2-(2{prime}-hydroxyphenyl)benzothiazole, -benzoxazole, and -benzimidazole derivatives have been prepared. Transmittance, fluorescence, light yield, and decay time characteristics of these compounds have been studied in a polystyrene matrix and evaluated for use in plastic scintillation detectors. Radiation damage studies utilizing a {sup 60}C source have also been performed.

  11. High resolution scintillation detector with semiconductor readout

    DOEpatents

    Levin, Craig S.; Hoffman, Edward J.

    2000-01-01

    A novel high resolution scintillation detector array for use in radiation imaging such as high resolution Positron Emission Tomography (PET) which comprises one or more parallelepiped crystals with at least one long surface of each crystal being in intimate contact with a semiconductor photodetector such that photons generated within each crystal by gamma radiation passing therethrough is detected by the photodetector paired therewith.

  12. Temperature dependence of BCF plastic scintillation detectors

    NASA Astrophysics Data System (ADS)

    Wootton, Landon; Beddar, Sam

    2013-05-01

    We examined temperature dependence in plastic scintillation detectors (PSDs) made of BCF-60 or BCF-12 scintillating fiber coupled to optical fiber with cyanoacrylate. PSDs were subjected to a range of temperatures using a temperature-controlled water bath and irradiated at each temperature while either the dose was measured using a CCD camera or the spectral output was measured using a spectrometer. The spectrometer was used to examine the intensity and spectral distribution of scintillation light emitted by the PSDs, Cerenkov light generated within the PSD, and light transmitted through an isolated optical coupling. BCF-60 PSDs exhibited a 0.50% decrease and BCF-12 PSDs a 0.09% decrease in measured dose per °C increase, relative to dose measured at 22 °C. Spectrometry revealed that the total intensity of the light generated by BCF-60 and BCF-12 PSDs decreased by 0.32% and 0.13%, respectively, per °C increase. The spectral distribution of the light changed slightly with temperature for both PSDs, accounting for the disparity between the change in measured dose and total light output. The generation of Cerenkov light was temperature independent. However, light transmitted through optical coupling between the scintillator and the optical fiber also exhibited temperature dependence.

  13. Progress in studying scintillator proportionality: Phenomenological model

    SciTech Connect

    Bizarri, Gregory; Cherepy, Nerine; Choong, Woon-Seng; Hull, Giulia; Moses, William; Payne, Sephen; Singh, Jai; Valentine, John; Vasilev, Andrey; Williams, Richard

    2009-04-30

    We present a model to describe the origin of non-proportional dependence of scintillator light yield on the energy of an ionizing particle. The non-proportionality is discussed in terms of energy relaxation channels and their linear and non-linear dependences on the deposited energy. In this approach, the scintillation response is described as a function of the deposited energy deposition and the kinetic rates of each relaxation channel. This mathematical framework allows both a qualitative interpretation and a quantitative fitting representation of scintillation non-proportionality response as function of kinetic rates. This method was successfully applied to thallium doped sodium iodide measured with SLYNCI, a new facility using the Compton coincidence technique. Finally, attention is given to the physical meaning of the dominant relaxation channels, and to the potential causes responsible for the scintillation non-proportionality. We find that thallium doped sodium iodide behaves as if non-proportionality is due to competition between radiative recombinations and non-radiative Auger processes.

  14. Waveshifting fiber readout of lanthanum halide scintillators

    NASA Astrophysics Data System (ADS)

    Case, G. L.; Cherry, M. L.; Stacy, J. G.

    2006-07-01

    Newly developed high-light-yield inorganic scintillators coupled to waveshifting optical fibers provide the capability of efficient X-ray detection and millimeter scale position resolution suitable for high-energy cosmic ray instruments, hard X-ray/gamma ray astronomy telescopes and applications to national security. The CASTER design for NASA's proposed Black Hole Finder Probe mission, in particular, calls for a 6 8 m2 hard X-ray coded aperture imaging telescope operating in the 20 600 keV energy band, putting significant constraints on cost and readout complexity. The development of new inorganic scintillator materials (e.g., cerium-doped LaBr3 and LaCl3) provides improved energy resolution and timing performance that is well suited to the requirements for national security and astrophysics applications. LaBr3 or LaCl3 detector arrays coupled with waveshifting fiber optic readout represent a significant advance in the performance capabilities of scintillator-based gamma cameras and provide the potential for a feasible approach to affordable, large area, extremely sensitive detectors. We describe some of the applications and present laboratory test results demonstrating the expected scintillator performance.

  15. Ionospheric scintillations associated with equatorial E-region

    NASA Technical Reports Server (NTRS)

    Chandra, H.; Vats, H. O.; Sethia, G.; Deshpande, M. R.; Rastogi, R. G.; Sastri, J. H.

    1978-01-01

    Amplitude scintillations at 40, 140, and 360 MHz recorded at an equatorial station Ootacamund (dip 4 deg N) during the ATS-6 phase II and the ionograms at a nearby station Kodaikanal (dip 3.5 deg N) are examined for the scintillation activity. Various sporadic E events, but not the Es-q, are associated with intense daytime scintillations. There are no scintillations at times of normal E-layer or cusp type of Es. Scintillations are also present at times of night Es.

  16. Liquid scintillator production for the NOvA experiment

    NASA Astrophysics Data System (ADS)

    Mufson, S.; Baugh, B.; Bower, C.; Coan, T. E.; Cooper, J.; Corwin, L.; Karty, J. A.; Mason, P.; Messier, M. D.; Pla-Dalmau, A.; Proudfoot, M.

    2015-11-01

    The NOvA collaboration blended and delivered 8.8 kt (2.72M gal) of liquid scintillator as the active detector medium to its near and far detectors. The composition of this scintillator was specifically developed to satisfy NOvA's performance requirements. A rigorous set of quality control procedures was put in place to verify that the incoming components and the blended scintillator met these requirements. The scintillator was blended commercially in Hammond, IN. The scintillator was shipped to the NOvA detectors using dedicated stainless steel tanker trailers cleaned to food grade.

  17. Liquid Scintillator Production for the NOvA Experiment

    DOE PAGESBeta

    Mufson, S.; Baugh, B.; Bower, C.; Coan, T.; Cooper, J.; Corwin, L.; Karty, J.; Mason, P.; Messier, M. D.; Pla-Dalmau, A.; et al

    2015-04-15

    The NOvA collaboration blended and delivered 8.8 kt (2.72M gal) of liquid scintillator as the active detector medium to its near and far detectors. The composition of this scintillator was specifically developed to satisfy NOvA's performance requirements. A rigorous set of quality control procedures was put in place to verify that the incoming components and the blended scintillator met these requirements. The scintillator was blended commercially in Hammond, IN. The scintillator was shipped to the NOvA detectors using dedicated stainless steel tanker trailers cleaned to food grade.

  18. Measurement of imaging properties of scintillating fiber optic plate

    NASA Astrophysics Data System (ADS)

    Zentai, George; Ganguly, Arundhuti; Star-Lack, Josh; Virshup, Gary; Hirsh, Hayley; Shedlock, Daniel; Humber, David

    2014-03-01

    Scintillating Fiber Optic Plates (SFOP) or Fiber Optic Scintillator (FOS) made with scintillating fiber-glass, were investigated for x-ray imaging. Two different samples (T x W x L = 2cm x 5cm x 5cm) were used; Sample A: 10μm fibers, Sample B: 50μm fibers both with statistically randomized light absorbing fibers placed in the matrix. A customized holder was used to place the samples in close contact with photodiodes in an amorphous silicon flat panel detector (AS1000, Varian), typically used for portal imaging. The detector has a 392μm pixel pitch and in the standard configuration uses a gadolinium oxy-sulphide (GOS) screen behind a copper plate. X-ray measurements were performed at 120kV (RQA 9 spectrum), 1MeV (5mm Al filtration) and 6MeV (Flattening Filter Free) for Sample A and the latter 2 spectra for Sample B. A machined edge was used for MTF measurements. The measurements showed the MTF degraded with increased X-ray energies because of the increase in Compton scattering. However, at the Nyquist frequency of 1.3lp/mm, the MTF is still high (FOS value vs. Cu+GOS): (a) 37% and 21% at 120kVp for the 10μm FOS and the Cu+GOS arrays, (b) 31%, 20% and 20% at 1MeV and (c) 17%, 11% and 14% at 6MeV for the 10μm FOS, 50μm FOS and the Cu+GOS arrays. The DQE(0) value comparison were (a) at 120kV ~24% and ~13 % for the 10μm FOS and the Cu+GOS arrays (b) at 1MV 10%, 10% and 7% and (c) at 6MV 12%, ~19% and 1.6% for the 10μm FOS , 50μm FOS and Cu+GOS arrays.

  19. Non-Carbon Dyes For Platic Scintillators- Report

    SciTech Connect

    Teprovich, J.; Colon-Mercado, H.; Gaillard, J.; Sexton, L.; Washington, A.; Ward, P.; Velten, J.

    2015-10-19

    Scintillation based detectors are desirable for many radiation detection applications (portal and border monitoring, safeguards verification, contamination detection and monitoring). The development of next generation scintillators will require improved detection sensitivity for weak gamma ray sources, and fast and thermal neutron quantification. Radiation detection of gamma and neutron sources can be accomplished with organic scintillators, however, the single crystals are difficult to grow for large area detectors and subject to cracking. Alternatives to single crystal organic scintillators are plastic scintillators (PS) which offer the ability to be shaped and scaled up to produce large sized detectors. PS is also more robust than the typical organic scintillator and are ideally suited for deployment in harsh real-world environments. PS contain a mixture of dyes to down-convert incident radiation into visible light that can be detected by a PMT. This project will evaluate the potential use of nano-carbon dyes in plastic scintillators.

  20. Study of the light guide system for CANDLES

    NASA Astrophysics Data System (ADS)

    Tsubota, Y.; CANDLES Collaboration

    2008-07-01

    We are trying to observe the neutrinoless double beta decay at Osaka University with the detector system named CANDLES III that uses CaF2(pure) crystals and liquid scintillator. CANDLES III has the photo-coverage of about 30% now. We will install the mirror light guide system to improve this photo-coverage. This means the improvement of the energy resolution. We will report on the result of the experiment to evaluate the performance of this light guide system.

  1. Application of the Strong Scatter Theory to the Interpretation of Ionospheric Scintillation Measurements along Geostationary Satellite Links at VHF and L-band

    NASA Astrophysics Data System (ADS)

    Carrano, C. S.; Groves, K. M.; Basu, S.; Mackenzie, E.; Sheehan, R. E.

    2013-12-01

    In a previous work, we demonstrated that ionospheric turbulence parameters may be inferred from amplitude scintillations well into in the strong scatter regime [Carrano et al., International Journal of Geophysics, 2012]. This technique, called Iterative Parameter Estimation (IPE), uses the strong scatter theory and numerical inversion to estimate the parameters of an ionospheric phase screen (turbulent intensity, phase spectral index, and irregularity zonal drift) consistent with the observed scintillations. The optimal screen parameters are determined such that the theoretical intensity spectrum on the ground best matches the measured intensity spectrum in a least squares sense. We use this technique to interpret scintillation measurements collected during a campaign at Ascension Island (7.96°S, 14.41°W) in March 2000, led by Santimay Basu and his collaborators from Air Force Research Laboratory. Geostationary satellites broadcasting radio signals at VHF and L-band were monitored along nearly co-linear links, enabling a multi-frequency analysis of scintillations with the same propagation geometry. The VHF data were acquired using antennas spaced in the magnetic east-west direction, which enabled direct measurement of the zonal irregularity drift. We show that IPE analysis of the VHF and L-Band scintillations, which exhibited very different statistics due to the wide frequency separation, yields similar estimates of the phase screen parameters that specify the disturbed ionospheric medium. This agreement provides confidence in our phase screen parameter estimates. It also suggests a technique for extrapolating scintillation measurements to frequencies other than those observed that is valid in the case of strong scatter. We find that IPE estimates of the zonal irregularity drift, made using scintillation observations along single space-to-ground link, are consistent with those measured independently using the spaced antenna technique. This encouraging result

  2. Characterizing energy dependence and count rate performance of a dual scintillator fiber-optic detector for computed tomography

    SciTech Connect

    Hoerner, Matthew R. Stepusin, Elliott J.; Hyer, Daniel E.; Hintenlang, David E.

    2015-03-15

    Purpose: Kilovoltage (kV) x-rays pose a significant challenge for radiation dosimetry. In the kV energy range, even small differences in material composition can result in significant variations in the absorbed energy between soft tissue and the detector. In addition, the use of electronic systems in light detection has demonstrated measurement losses at high photon fluence rates incident to the detector. This study investigated the feasibility of using a novel dual scintillator detector and whether its response to changes in beam energy from scatter and hardening is readily quantified. The detector incorporates a tissue-equivalent plastic scintillator and a gadolinium oxysulfide scintillator, which has a higher sensitivity to scatter x-rays. Methods: The detector was constructed by coupling two scintillators: (1) small cylindrical plastic scintillator, 500 μm in diameter and 2 mm in length, and (2) 100 micron sheet of gadolinium oxysulfide 500 μm in diameter, each to a 2 m long optical fiber, which acts as a light guide to transmit scintillation photons from the sensitive element to a photomultiplier tube. Count rate linearity data were obtained from a wide range of exposure rates delivered from a radiological x-ray tube by adjusting the tube current. The data were fitted to a nonparalyzable dead time model to characterize the time response. The true counting rate was related to the reference free air dose air rate measured with a 0.6 cm{sup 3} Radcal{sup ®} thimble chamber as described in AAPM Report No. 111. Secondary electron and photon spectra were evaluated using Monte Carlo techniques to analyze ionization quenching and photon energy-absorption characteristics from free-in-air and in phantom measurements. The depth/energy dependence of the detector was characterized using a computed tomography dose index QA phantom consisting of nested adult head and body segments. The phantom provided up to 32 cm of acrylic with a compatible 0.6 cm{sup 3} calibrated

  3. A new type of thermal-neutron detector based on ZnS(Ag)/LiF scintillator and avalanche photodiodes

    NASA Astrophysics Data System (ADS)

    Marin, V. N.; Sadykov, R. A.; Trunov, D. N.; Litvin, V. S.; Aksenov, S. N.; Stolyarov, A. A.

    2015-09-01

    A high-efficiency thermal-neutron detector based on ZnS(Ag)/LiF scintillator is described, which employs a new technique of signal pick-up with the aid of a light guide and avalanche photodiodes instead of optical fibers and photomultipliers. Results of tests on the RADEX pulsed neutron source are presented, in which neutron diffraction patterns of test objects have been obtained.

  4. Calculations and measurements of the scintillator-to-water stopping power ratio of liquid scintillators for use in proton radiotherapy

    PubMed Central

    Ingram, W. Scott; Robertson, Daniel; Beddar, Sam

    2015-01-01

    Liquid scintillators are a promising detector for high-resolution three-dimensional proton therapy dosimetry. Because the scintillator comprises both the active volume of the detector and the phantom material, an ideal scintillator will exhibit water equivalence in its radiological properties. One of the most fundamental of these is the scintillator’s stopping power. The objective of this study was to compare calculations and measurements of scintillator-to-water stopping power ratios to evaluate the suitability of the liquid scintillators BC-531 and OptiPhase HiSafe 3 for proton dosimetry. We also measured the relative scintillation output of the two scintillators. Both calculations and measurements show that the linear stopping power of OptiPhase is significantly closer to water than that of BC-531. BC-531 has a somewhat higher scintillation output. OptiPhase can be mixed with water at high concentrations, which further improves its scintillator-to-water stopping power ratio. However, this causes the solution to become cloudy, which has a negative impact on the scintillation output and spatial resolution of the detector. OptiPhase is preferred over BC-531 for proton dosimetry because its density and scintillator-to-water stopping power ratio are more water equivalent. PMID:25705066

  5. Neutron spectroscopy with scintillation detectors using wavelets

    NASA Astrophysics Data System (ADS)

    Hartman, Jessica

    The purpose of this research was to study neutron spectroscopy using the EJ-299-33A plastic scintillator. This scintillator material provided a novel means of detection for fast neutrons, without the disadvantages of traditional liquid scintillation materials. EJ-299-33A provided a more durable option to these materials, making it less likely to be damaged during handling. Unlike liquid scintillators, this plastic scintillator was manufactured from a non-toxic material, making it safer to use, as well as easier to design detectors. The material was also manufactured with inherent pulse shape discrimination abilities, making it suitable for use in neutron detection. The neutron spectral unfolding technique was developed in two stages. Initial detector response function modeling was carried out through the use of the MCNPX Monte Carlo code. The response functions were developed for a monoenergetic neutron flux. Wavelets were then applied to smooth the response function. The spectral unfolding technique was applied through polynomial fitting and optimization techniques in MATLAB. Verification of the unfolding technique was carried out through the use of experimentally determined response functions. These were measured on the neutron source based on the Van de Graff accelerator at the University of Kentucky. This machine provided a range of monoenergetic neutron beams between 0.1 MeV and 24 MeV, making it possible to measure the set of response functions of the EJ-299-33A plastic scintillator detector to neutrons of specific energies. The response of a plutonium-beryllium (PuBe) source was measured using the source available at the University of Nevada, Las Vegas. The neutron spectrum reconstruction was carried out using the experimentally measured response functions. Experimental data was collected in the list mode of the waveform digitizer. Post processing of this data focused on the pulse shape discrimination analysis of the recorded response functions to remove the

  6. Nonproportionality of Scintillator Detectors: Theory and Experiment

    SciTech Connect

    Payne, Stephen; Cherepy, Nerine; Hull, Giulia; Valentine, John; Moses, William; Choong, Woon-Seng

    2009-08-17

    On the basis of nonproportionality data obtained for several scintillators, we have developed a theory to describe the carrier dynamics to fit the light yield versus electron energy. The theory of Onsager was adapted to explain how the carriers form excitons or sequentially arrive at the activators to promote the ion to an excited state, and the theory of Birks was employed to allow for exciton-exciton annihilation. We then developed a second theory to deduce the degradation in resolution that results from nonproportionality by evoking Landau fluctuations, which are essentially variations in the deposited energy density that occur as the high energy electron travels along its trajectory. In general there is good agreement with the data, in terms of fitting the nonproportionality curves and reproducing the literature values of nonproportionality's contribution to the scintillator resolution. With the resurgence of interest in developing scintillator detectors that have good energy resolution, an improved understanding of nonproportionality has become a crucial matter since it presents the fundamental limit to the achievable resolution. In order to hasten an improved understanding of scintillator nonproportionality, we have constructed an instrument referred to as SLYNCI (Scintillator Light Yield Nonproportionality Compton Instrument). This is a second-generation instrument to the original device developed by Valentine and coworkers, wherein several new principles of operation have served to increase the data rate by an order of magnitude as discussed in detail in References. In the present article, the focus is on a theory to describe the measured electron response, which is the light yield as a function of the electron energy. To do this, we account for transport of carriers and excitons, in terms of how they transfer their energy to the activators with competition from nonradiative decay pathways. This work builds on the original work of Murray and coworkers, and

  7. Real-time Scintillation Monitoring in Alaska from a Longitudinal Chain of ASTRA's SM-211 GPS TEC and Scintillation Receivers

    NASA Astrophysics Data System (ADS)

    Crowley, G.; Azeem, S. I.; Reynolds, A.; Santana, J.; Hampton, D. L.

    2013-12-01

    Amplitude and phase scintillation can cause serious difficulties for GPS receivers. Intense scintillation can cause loss of lock. High latitude studies generally show that phase scintillation can be severe, but the amplitude scintillation tends to be small. The reason for this is not yet understood. Furthermore, the actual causes of the ionospheric irregularities that produce high latitude scintillation are not well understood. While the gradient drift instability is thought to be important in the F-region, there may be other structures present in either the E- or F-regions. The role of particle precipitation is also not well understood. Four of ASTRA's CASES GPS receivers were deployed in Alaska to demonstrate our ability to map scintillation in realtime, to provide space weather services to GPS users, and to initiate a detailed investigation of these effects. These dual-frequency GPS receivers measure total electron content (TEC) and scintillation. The scintillation monitors were deployed in a longitudinal chain at sites in Kaktovic, Fort Yukon, Poker Flat, and Gakona. Scintillation statistics show phase scintillations to be largest at Kaktovic and smallest at Gakona. We present GPS phase scintillation and auroral emission results from the Alaska chain to characterize the correspondence between scintillation and auroral features, and to investigate the role of high latitude auroral features in driving the phase scintillations. We will also present data showing how phase scintillation can cause other GPS receivers to lose lock. The data and results are particularly valuable because they illustrate some of the challenges of using GPS systems for positioning and navigation in an auroral region like Alaska. These challenges for snowplough drivers were recently highlighted, along with the CASES SM-211 space weather monitor, in a special video in which ASTRA and three other small businesses were presented with an entrepreneurial award from William Shatner (http://youtu.be/bIVKEQH_YPk).

  8. Monte Carlo investigations of the effect of beam divergence on thick, segmented crystalline scintillators for radiotherapy imaging

    NASA Astrophysics Data System (ADS)

    Wang, Yi; El-Mohri, Youcef; Antonuk, Larry E.; Zhao, Qihua

    2010-07-01

    The use of thick, segmented scintillators in electronic portal imagers offers the potential for significant improvement in x-ray detection efficiency compared to conventional phosphor screens. Such improvement substantially increases the detective quantum efficiency (DQE), leading to the possibility of achieving soft-tissue visualization at clinically practical (i.e. low) doses using megavoltage (MV) cone-beam computed tomography. While these DQE increases are greatest at zero spatial frequency, they are diminished at higher frequencies as a result of degradation of spatial resolution due to lateral spreading of secondary radiation within the scintillator—an effect that is more pronounced for thicker scintillators. The extent of this spreading is even more accentuated for radiation impinging the scintillator at oblique angles of incidence due to beam divergence. In this paper, Monte Carlo simulations of radiation transport, performed to investigate and quantify the effects of beam divergence on the imaging performance of MV imagers based on two promising scintillators (BGO and CsI:Tl), are reported. In these studies, 10-40 mm thick scintillators, incorporating low-density polymer, or high-density tungsten septal walls, were examined for incident angles corresponding to that encountered at locations up to ~15 cm from the central beam axis (for an imager located 130 cm from a radiotherapy x-ray source). The simulations demonstrate progressively more severe spatial resolution degradation (quantified in terms of the effect on the modulation transfer function) as a function of increasing angle of incidence (as well as of the scintillator thickness). Since the noise power behavior was found to be largely independent of the incident angle, the dependence of the DQE on the incident angle is therefore primarily determined by the spatial resolution. The observed DQE degradation suggests that 10 mm thick scintillators are not strongly affected by beam divergence for

  9. Genetic screening

    PubMed Central

    Andermann, Anne; Blancquaert, Ingeborg

    2010-01-01

    Abstract OBJECTIVE To provide a primer for primary care professionals who are increasingly called upon to discuss the growing number of genetic screening services available and to help patients make informed decisions about whether to participate in genetic screening, how to interpret results, and which interventions are most appropriate. QUALITY OF EVIDENCE As part of a larger research program, a wide literature relating to genetic screening was reviewed. PubMed and Internet searches were conducted using broad search terms. Effort was also made to identify the gray literature. MAIN MESSAGE Genetic screening is a type of public health program that is systematically offered to a specified population of asymptomatic individuals with the aim of providing those identified as high risk with prevention, early treatment, or reproductive options. Ensuring an added benefit from screening, as compared with standard clinical care, and preventing unintended harms, such as undue anxiety or stigmatization, depends on the design and implementation of screening programs, including the recruitment methods, education and counseling provided, timing of screening, predictive value of tests, interventions available, and presence of oversight mechanisms and safeguards. There is therefore growing apprehension that economic interests might lead to a market-driven approach to introducing and expanding screening before program effectiveness, acceptability, and feasibility have been demonstrated. As with any medical intervention, there is a moral imperative for genetic screening to do more good than harm, not only from the perspective of individuals and families, but also for the target population and society as a whole. CONCLUSION Primary care professionals have an important role to play in helping their patients navigate the rapidly changing terrain of genetic screening services by informing them about the benefits and risks of new genetic and genomic technologies and empowering them to

  10. Screening Jews and genes: a consideration of the ethics of genetic screening within the Jewish community: challenges and responses.

    PubMed

    Levin, M

    1999-01-01

    Screening for genetic disorders, particularly Tay-Sachs Disease, has been traditionally welcome by the Jewish community. I review the history of genetic screening among Jews and the views from the Jewish tradition on the subject, and then discuss ethical challenges of screening and the impact of historical memories upon future acceptance of screening programs. Some rational principles to guide future design of genetic screening programs among Jews are proposed. PMID:10464669

  11. An experimental method to determine the effective luminescence efficiency of scintillator-photodetector combinations used in X-ray medical imaging systems.

    PubMed

    Cavouras, D; Kandarakis, I; Bakas, A; Triantis, D; Nomicos, C D; Panayiotakis, G S

    1998-07-01

    The scintillator effective luminescence efficiency, which may be defined in terms of the scintillator's X-ray luminescence efficiency and the scintillator-photodetector spectral matching and geometrical configuration, was studied for various X-ray imaging applications. Four scintillator materials Gd2O2S:Tb, Y2O2S:Tb, ZnSCdS:Ag and CsI:Na were used to prepare test screens. They were evaluated in relation to various photodetectors used in X-ray imaging, such as radiographic films, photocathodes, and photodiodes. Effective luminescence efficiency was determined for a range of X-ray tube voltages (50-140 kVp) by measuring the light flux emitted per unit of incident exposure rate and the spectra of the light emitted by the four scintillators. Scintillator-photodetector combinations resulting in higher image brightness level were determined for different X-ray imaging systems. Findings indicate that CsI:Na is very efficient with orthochromatic radiographic films, Gd2O2S:Tb could be useful in conventional or digital fluoroscopy and in CT and ZnSCdS:Ag could be employed in some medium to low voltage digital radiography applications. PMID:9771388

  12. Divalent europium doped and un-doped calcium iodide scintillators: Scintillator characterization and single crystal growth

    SciTech Connect

    Boatner, L. A.; Ramey, J. O.; Kolopus, J. A.; Neal, John S.

    2015-02-21

    Initially, the alkaline-earth scintillator, CaI2:Eu2+, was discovered around 1964 by Hofstadter, Odell, and Schmidt. Serious practical problems quickly arose, however, that were associated with the growth of large monolithic single crystals of this material due to its lamellar, mica-like structure. As a result of its theoretically higher light yield, CaI2:Eu2+ has the potential to exceed the excellent scintillation performance of SrI2:Eu2+. In fact, theoretical predictions for the light yield of CaI2:Eu2+ scintillators suggested that an energy resolution approaching 2% at 662 keV could be achievable. Like the early SrI2:Eu2+ scintillator, the performance of CaI2:Eu2+ scintillators has traditionally suffered due, at least in part, to outdated materials synthesis, component stoichiometry/purity, and single-crystal-growth techniques. Based on our recent work on SrI2:Eu2+ scintillators in single-crystal form, we have developed new techniques that are applied here to CaI2:Eu2+ and pure CaI2 with the goal of growing large un-cracked crystals and, potentially, realizing the theoretically predicted performance of the CaI2:Eu2+ form of this material. Calcium iodide does not adhere to modern glassy carbon Bridgman crucibles - so there should be no differential thermal-contraction-induced crystal/crucible stresses on cooling that would result in crystal cracking of the lamellar structure of CaI2. Here we apply glassy carbon crucible Bridgman growth, high-purity growth-charge compounds, our molten salt processing/filtration technique, and extended vacuum-melt-pumping methods to the growth of both CaI2:Eu2+ and un-doped CaI2. Moreover, large scintillating single crystals were obtained, and detailed characterization studies of the

  13. Divalent europium doped and un-doped calcium iodide scintillators: Scintillator characterization and single crystal growth

    DOE PAGESBeta

    Boatner, L. A.; Ramey, J. O.; Kolopus, J. A.; Neal, John S.

    2015-02-21

    Initially, the alkaline-earth scintillator, CaI2:Eu2+, was discovered around 1964 by Hofstadter, Odell, and Schmidt. Serious practical problems quickly arose, however, that were associated with the growth of large monolithic single crystals of this material due to its lamellar, mica-like structure. As a result of its theoretically higher light yield, CaI2:Eu2+ has the potential to exceed the excellent scintillation performance of SrI2:Eu2+. In fact, theoretical predictions for the light yield of CaI2:Eu2+ scintillators suggested that an energy resolution approaching 2% at 662 keV could be achievable. Like the early SrI2:Eu2+ scintillator, the performance of CaI2:Eu2+ scintillators has traditionally suffered due, atmore » least in part, to outdated materials synthesis, component stoichiometry/purity, and single-crystal-growth techniques. Based on our recent work on SrI2:Eu2+ scintillators in single-crystal form, we have developed new techniques that are applied here to CaI2:Eu2+ and pure CaI2 with the goal of growing large un-cracked crystals and, potentially, realizing the theoretically predicted performance of the CaI2:Eu2+ form of this material. Calcium iodide does not adhere to modern glassy carbon Bridgman crucibles - so there should be no differential thermal-contraction-induced crystal/crucible stresses on cooling that would result in crystal cracking of the lamellar structure of CaI2. Here we apply glassy carbon crucible Bridgman growth, high-purity growth-charge compounds, our molten salt processing/filtration technique, and extended vacuum-melt-pumping methods to the growth of both CaI2:Eu2+ and un-doped CaI2. Moreover, large scintillating single crystals were obtained, and detailed characterization studies of the scintillation properties of CaI2:Eu2+ and pure CaI2 single crystals are presented that include studies of the effects of plastic deformation of the crystals on the scintillator performance.« less

  14. Discriminated neutron and X-ray radiography using multi-color scintillation detector

    NASA Astrophysics Data System (ADS)

    Nittoh, Koichi; Takahara, Takeshi; Yoshida, Tadashi; Tamura, Toshiyuki

    1999-06-01

    A new conversion screen Gd 2O 2S:Eu is developed, which emits red light on irradiation by thermal neutrons. By applying this in combination with the currently used Gd 2O 2S:Tb, a green-light scintillator, in the radiography under a neutron + X-ray coexisting field, we can easily separate the neutron image and the X-ray image by simple color-image processing. This technique enables a non-destructive and detailed inspection of industrial products composed both of light elements (water, plastics, etc.) and heavy elements (metals), widening the horizon of new applications.

  15. Reflectance of polytetrafluoroethylene for xenon scintillation light

    SciTech Connect

    Silva, C.; Pinto da Cunha, J.; Pereira, A.; Chepel, V.; Lopes, M. I.; Solovov, V.; Neves, F.

    2010-03-15

    Gaseous and liquid xenon particle detectors are being used in a number of applications including dark matter search and neutrino-less double beta decay experiments. Polytetrafluoroethylene (PTFE) is often used in these detectors both as electrical insulator and as a light reflector to improve the efficiency of detection of scintillation photons. However, xenon emits in the vacuum ultraviolet (VUV) wavelength region ({lambda}{approx_equal}175 nm) where the reflecting properties of PTFE are not sufficiently known. In this work, we report on measurements of PTFE reflectance, including its angular distribution, for the xenon scintillation light. Various samples of PTFE, manufactured by different processes (extruded, expanded, skived, and pressed) have been studied. The data were interpreted with a physical model comprising both specular and diffuse reflections. The reflectance obtained for these samples ranges from about 47% to 66% for VUV light. Other fluoropolymers, namely, ethylene tetrafluoroethylene (ETFE), fluorinated ethylene propylene (FEP), and perfluoro-alkoxyalkane (PFA) were also measured.

  16. Scintillating 99Tc Selective Ion Exchange Resins

    SciTech Connect

    Mitchell Greenhalgh; Richard D. Tillotson

    2012-07-01

    Scintillating technetium (99Tc) selective ion exchange resins have been developed and evaluated for equilibrium capacities and detection efficiencies. These resins can be utilized for the in-situ concentration and detection of low levels of pertechnetate anions (99TcO4-) in natural waters. Three different polystyrene type resin support materials were impregnated with varying amounts of tricaprylmethylammonium chloride (Aliquat 336) extractant, several different scintillating fluors and wavelength shifters. The prepared resins were contacted batch-wise to equilibrium over a wide range of 99TcO4- concentrations in natural water. The measured capacities were used to develop Langmuir adsorption isotherms for each resin. 99Tc detection efficiencies were determined and up to 71.4 ± 2.6% was achieved with some resins. The results demonstrate that a low level detection limit for 99TcO4- in natural waters can be realized.

  17. Neutron detection with single crystal organic scintillators

    SciTech Connect

    Zaitseva, N; Newby, J; Hamel, S; Carman, L; Faust, M; Lordi, V; Cherepy, N; Stoeffl, W; Payne, S

    2009-07-15

    Detection of high-energy neutrons in the presence of gamma radiation background utilizes pulse-shape discrimination (PSD) phenomena in organics studied previously only with limited number of materials, mostly liquid scintillators and single crystal stilbene. The current paper presents the results obtained with broader varieties of luminescent organic single crystals. The studies involve experimental tools of crystal growth and material characterization in combination with the advanced computer modeling, with the final goal of better understanding the relevance between the nature of the organic materials and their PSD properties. Special consideration is given to the factors that may diminish or even completely obscure the PSD properties in scintillating crystals. Among such factors are molecular and crystallographic structures that determine exchange coupling and exciton mobility in organic materials and the impurity effect discussed on the examples of trans-stilbene, bibenzyl, 9,10-diphenylanthracene and diphenylacetylene.

  18. Effects of light on scintillating fibers

    NASA Astrophysics Data System (ADS)

    Chung, Manho; Margulies, Seymour

    1993-10-01

    Tracking detectors based on scintillating-fiber technology are being developed for the Solenoidal Detector Collaboration at the Superconducting Super Collider and for the D0 collaboration at Fermilab. An important part of the work is to insure that the fibers will not be damaged by environmental conditions in the course of detector construction. This paper presents preliminary results of the effects of ambient fluorescent light on scintillating fibers containing 3-hydroxyflavone (3HF) waveshifter. Six fiber types having 3HF concentrations between 100 ppm and 6000 ppm were studied; both single-clad fibers from Bicron and Kuraray and a new Kuraray multiclad fiber were included. A blue fiber containing no 3HF was used to provide a comparison.

  19. Development of High-Resolution Scintillator Systems

    SciTech Connect

    Larry A. Franks; Warnick J. Kernan

    2007-09-01

    Mercuric iodide (HgI2) is a well known material for the direct detection of gamma-rays; however, the largest volume achievable is limited by the thickness of the detector which needs to be a small fraction of the average trapping length for electrons. We report results of using HgI2 crystals to fabricate photocells used in the readout of scintillators. The optical spectral response and efficiency of these photocells were measured and will be reported. Nuclear response from an HgI2 photocell that was optically matched to a cerium-activated scintillator is presented and discussed. Further improvements can be expected by optimizing the transparent contact technology.

  20. Scintillator phase of the SNO+ experiment

    NASA Astrophysics Data System (ADS)

    Lozza, V.; SNO+ Collaboration

    2012-07-01

    The SNO+ experiment is the follow up of the SNO experiment, replacing the heavy water volume with about 780 tons of liquid scintillator (LAB) in order to shift the sensitive threshold to lower energy range. The 6000 m.w.e. natural rock shielding, and the use of ultra-clean materials makes the detector suitable for the detection of pep and CNO solar neutrinos, geo-neutrinos, reactor neutrinos and the possible observation of neutrinos from supernovae. Complementing this program, SNO+ will also search for 150Nd (5.6% abundance) neutrinoless double beta decay, loading the liquid scintillator with 0.1% of natural Neodymium. After a review of the general SNO+ setup, the physics of the solar neutrino phase will be presented.

  1. Neutron detection with single crystal organic scintillators

    NASA Astrophysics Data System (ADS)

    Zaitseva, Natalia P.; Newby, Jason; Hamel, Sebastien; Carman, Leslie; Faust, Michelle; Lordi, Vincenzo; Cherepy, Nerine J.; Stoeffl, Wolfgang; Payne, Stephen A.

    2009-08-01

    Detection of high-energy neutrons in the presence of gamma radiation background utilizes pulse-shape discrimination (PSD) phenomena in organics studied previously only with limited number of materials, mostly liquid scintillators and single crystal stilbene. The current paper presents the results obtained with broader varieties of luminescent organic single crystals. The studies involve experimental tools of crystal growth and material characterization in combination with the advanced computer modeling, with the final goal of better understanding the relevance between the nature of the organic materials and their PSD properties. Special consideration is given to the factors that may diminish or even completely obscure the PSD properties in scintillating crystals. Among such factors are molecular and crystallographic structures that determine exchange coupling and exciton mobility in organic materials and the impurity effect discussed on the examples of trans-stilbene, bibenzyl, 9,10- diphenylanthracene and diphenylacetylene.

  2. Plastic fiber scintillator response to fast neutrons

    NASA Astrophysics Data System (ADS)

    Danly, C. R.; Sjue, S.; Wilde, C. H.; Merrill, F. E.; Haight, R. C.

    2014-11-01

    The Neutron Imaging System at NIF uses an array of plastic scintillator fibers in conjunction with a time-gated imaging system to form an image of the neutron emission from the imploded capsule. By gating on neutrons that have scattered from the 14.1 MeV DT energy to lower energy ranges, an image of the dense, cold fuel around the hotspot is also obtained. An unmoderated spallation neutron beamline at the Weapons Neutron Research facility at Los Alamos was used in conjunction with a time-gated imaging system to measure the yield of a scintillating fiber array over several energy bands ranging from 1 to 15 MeV. The results and comparison to simulation are presented.

  3. Codoped direct-gap semiconductor scintillators

    DOEpatents

    Derenzo, Stephen Edward; Bourret-Courchesne, Edith; Weber, Marvin J.; Klintenberg, Mattias K.

    2008-07-29

    Fast, bright inorganic scintillators at room temperature are based on radiative electron-hole recombination in direct-gap semiconductors, e.g. CdS and ZnO. The direct-gap semiconductor is codoped with two different impurity atoms to convert the semiconductor to a fast, high luminosity scintillator. The codopant scheme is based on dopant band to dopant trap recombination. One dopant provides a significant concentration of carriers of one type (electrons or holes) and the other dopant traps carriers of the other type. Examples include CdS:In,Te; CdS:In,Ag; CdS:In,Na; ZnO:Ga,P; ZnO:Ga,N; ZnO:Ga,S; and GaN:Ge,Mg.

  4. Codoped direct-gap semiconductor scintillators

    DOEpatents

    Derenzo, Stephen E.; Bourret-Courchesne, Edith; Weber, Marvin J.; Klintenberg, Mattias K.

    2006-05-23

    Fast, bright inorganic scintillators at room temperature are based on radiative electron-hole recombination in direct-gap semiconductors, e.g. CdS and ZnO. The direct-gap semiconductor is codoped with two different impurity atoms to convert the semiconductor to a fast, high luminosity scintillator. The codopant scheme is based on dopant band to dopant trap recombination. One dopant provides a significant concentration of carriers of one type (electrons or holes) and the other dopant traps carriers of the other type. Examples include CdS:In,Te; CdS:In,Ag; CdS:In,Na; ZnO:Ga,P; ZnO:Ga,N; ZnO:Ga,S; and GaN:Ge,Mg.

  5. Reflectance of polytetrafluoroethylene for xenon scintillation light

    NASA Astrophysics Data System (ADS)

    Silva, C.; Pinto da Cunha, J.; Pereira, A.; Chepel, V.; Lopes, M. I.; Solovov, V.; Neves, F.

    2010-03-01

    Gaseous and liquid xenon particle detectors are being used in a number of applications including dark matter search and neutrino-less double beta decay experiments. Polytetrafluoroethylene (PTFE) is often used in these detectors both as electrical insulator and as a light reflector to improve the efficiency of detection of scintillation photons. However, xenon emits in the vacuum ultraviolet (VUV) wavelength region (λ ≃175 nm) where the reflecting properties of PTFE are not sufficiently known. In this work, we report on measurements of PTFE reflectance, including its angular distribution, for the xenon scintillation light. Various samples of PTFE, manufactured by different processes (extruded, expanded, skived, and pressed) have been studied. The data were interpreted with a physical model comprising both specular and diffuse reflections. The reflectance obtained for these samples ranges from about 47% to 66% for VUV light. Other fluoropolymers, namely, ethylene tetrafluoroethylene (ETFE), fluorinated ethylene propylene (FEP), and perfluoro-alkoxyalkane (PFA) were also measured.

  6. Plastic fiber scintillator response to fast neutrons

    SciTech Connect

    Danly, C. R.; Sjue, S.; Wilde, C. H.; Merrill, F. E.; Haight, R. C.

    2014-11-15

    The Neutron Imaging System at NIF uses an array of plastic scintillator fibers in conjunction with a time-gated imaging system to form an image of the neutron emission from the imploded capsule. By gating on neutrons that have scattered from the 14.1 MeV DT energy to lower energy ranges, an image of the dense, cold fuel around the hotspot is also obtained. An unmoderated spallation neutron beamline at the Weapons Neutron Research facility at Los Alamos was used in conjunction with a time-gated imaging system to measure the yield of a scintillating fiber array over several energy bands ranging from 1 to 15 MeV. The results and comparison to simulation are presented.

  7. Transparent Ceramic Scintillator Fabrication, Properties and Applications

    SciTech Connect

    Cherepy, N J; Kuntz, J D; Roberts, J J; Hurst, T A; Drury, O B; Sanner, R D; Tillotson, T M; Payne, S A

    2008-08-24

    Transparent ceramics offer an alternative to single crystals for scintillator applications such as gamma ray spectroscopy and radiography. We have developed a versatile, scaleable fabrication method, using Flame Spray Pyrolysis (FSP) to produce feedstock which is readily converted into phase-pure transparent ceramics. We measure integral light yields in excess of 80,000 Ph/MeV with Cerium-doped Garnets, and excellent optical quality. Avalanche photodiode readout of Garnets provides resolution near 6%. For radiography applications, Lutetium Oxide offers a high performance metric and is formable by ceramics processing. Scatter in transparent ceramics due to secondary phases is the principal limitation to optical quality, and afterglow issues that affect the scintillation performance are presently being addressed.

  8. Development of an Ultra-Low Background Liquid Scintillation Counter for Trace Level Analysis

    SciTech Connect

    Erchinger, Jennifer L.; Orrell, John L.; Aalseth, Craig E.; Bernacki, Bruce E.; Douglas, Matthew; Finn, Erin C.; Fuller, Erin S.; Keillor, Martin E.; Morley, Shannon M.; Mullen, Crystal A.; Panisko, Mark E.; Shaff, Sarah M.; Warren, Glen A.; Wright, Michael E.

    2015-09-01

    Low-level liquid scintillation counting (LSC) has been established as one of the radiation detection techniques useful in elucidating environmental processes and environmental monitoring around nuclear facilities. The Ultra-Low Background Liquid Scintillation Counter (ULB-LSC) under construction in the Shallow Underground Laboratory at Pacific Northwest National Laboratory aims to further reduce the MDAs and/or required sample processing. Through layers of passive shielding in conjunction with an active veto and 30 meters water equivalent overburden, the background reduction is expected to be 10 to 100 times below typical analytic low-background liquid scintillation systems. Simulations have shown an expected background of around 14 counts per day. A novel approach to the light collection will use a coated hollow light guide cut into the inner copper shielding. Demonstration LSC measurements will show low-energy detection, spectral deconvolution, and alpha/beta discrimination capabilities, from trials with standards of tritium, strontium-90, and actinium-227, respectively. An overview of the system design and expected demonstration measurements will emphasize the potential applications of the ULB-LSC in environmental monitoring for treaty verification, reach-back sample analysis, and facility inspections.

  9. Scintillating Quantum Dots for Imaging X-rays (SQDIX) for Aircraft Inspection

    NASA Technical Reports Server (NTRS)

    Burke, Eric (Principal Investigator); Williams, Phillip (Principal Investigator); Dehaven, Stan

    2015-01-01

    Scintillation is the process currently employed by conventional x-ray detectors to create x-ray images. Scintillating quantum dots or nano-crystals (StQDs) are a novel, nanometer-scale material that upon excitation by x-rays, re-emit the absorbed energy as visible light. StQDs theoretically have higher output efficiency than conventional scintillating materials and are more environmental friendly. This paper will present the characterization of several critical elements in the use of StQDs that have been performed along a path to the use of this technology in wide spread x-ray imaging. Initial work on the SQDIX system has shown great promise to create state-of-the-art sensors using StQDs as a sensor material. In addition, this work also demonstrates a high degree of promise using StQDs in microstructured fiber optics. Using the microstructured fiber as a light guide could greatly increase the capture efficiency a StQDs based imaging sensor.

  10. Nanophosphor composite scintillators comprising a polymer matrix

    DOEpatents

    Muenchausen, Ross Edward; Mckigney, Edward Allen; Gilbertson, Robert David

    2010-11-16

    An improved nanophosphor composite comprises surface modified nanophosphor particles in a solid matrix. The nanophosphor particle surface is modified with an organic ligand, or by covalently bonding a polymeric or polymeric precursor material. The surface modified nanophosphor particle is essentially charge neutral, thereby preventing agglomeration of the nanophosphor particles during formation of the composite material. The improved nanophosphor composite may be used in any conventional scintillator application, including in a radiation detector.

  11. Sorohalide scintillators, phosphors, and uses thereof

    DOEpatents

    Yang, Pin; Deng, Haoran; Doty, F. Patrick; Zhou, Xiaowang

    2016-05-10

    The present invention relates to sorohalide compounds having formula A.sub.3B.sub.2X.sub.9, where A is an alkali metal, B is a rare earth metal, and X is a halogen. Optionally, the sorohalide includes a dopant D. Such undoped and doped sorohalides are useful as scintillation materials or phosphors for any number of uses, including for radiation detectors, solid-state light sources, gamma-ray spectroscopy, medical imaging, and drilling applications.

  12. Simulating Silicon Photomultiplier Response to Scintillation Light

    PubMed Central

    Jha, Abhinav K.; van Dam, Herman T.; Kupinski, Matthew A.; Clarkson, Eric

    2015-01-01

    The response of a Silicon Photomultiplier (SiPM) to optical signals is affected by many factors including photon-detection efficiency, recovery time, gain, optical crosstalk, afterpulsing, dark count, and detector dead time. Many of these parameters vary with overvoltage and temperature. When used to detect scintillation light, there is a complicated non-linear relationship between the incident light and the response of the SiPM. In this paper, we propose a combined discrete-time discrete-event Monte Carlo (MC) model to simulate SiPM response to scintillation light pulses. Our MC model accounts for all relevant aspects of the SiPM response, some of which were not accounted for in the previous models. We also derive and validate analytic expressions for the single-photoelectron response of the SiPM and the voltage drop across the quenching resistance in the SiPM microcell. These analytic expressions consider the effect of all the circuit elements in the SiPM and accurately simulate the time-variation in overvoltage across the microcells of the SiPM. Consequently, our MC model is able to incorporate the variation of the different SiPM parameters with varying overvoltage. The MC model is compared with measurements on SiPM-based scintillation detectors and with some cases for which the response is known a priori. The model is also used to study the variation in SiPM behavior with SiPM-circuit parameter variations and to predict the response of a SiPM-based detector to various scintillators. PMID:26236040

  13. Improved Neutron Scintillators Based on Nanomaterials

    SciTech Connect

    Dennis Friesel, PhD

    2008-06-30

    The development work conducted in this SBIR has so far not supported the premise that using nano-particles in LiFZnS:Ag foils improves their transparency to 420 (or other frequency) light. This conclusion is based solely on the light absorption properties of LiFZnS foils fabricated from nano- and from micro-particles. Furthermore, even for the case of the Gd{sub 2}O{sub 3} foils, the transmission of 420 nm light gained by using nano-particles all but disappears as the foil thickness is increased beyond about 0.2 mm, a practical scintillator thickness. This was not immediately apparent from the preliminary study since no foils thicker than about 0.04 mm were produced. Initially it was believed that the failure to see an improvement by using nano-particles for the LiFZnS foils was caused by the clumping of the particles in Toluene due to the polarity of the ZnS particles. However, we found, much to our surprise, that nano-particle ZnS alone in polystyrene, and in Epoxy, had worse light transmission properties than the micro-particle foils for equivalent thickness and density foils. The neutron detection measurements, while disappointing, are attributable to our inability to procure or fabricate Bulk Doped ZnS nanoparticles. The cause for the failure of nano-particles to improve the scintillation light, and hence improved neutron detection efficiency, is a fundamental one of light scattering within the scintillator. A consequence of PartTec's documentation of this is that several concepts for the fabrication of improved {sup 6}LiFZnS scintillators were formulated that will be the subject of a future SBIR submission.

  14. Characteristics of Yerevan High Transparency Scintillators

    SciTech Connect

    Zorn, Carl; Asryan, Gegham; Egiyan, Kim; Tarverdyan, M.; Amaryan, Moscov; Amaryan, Moskov; Demirchyan, Raphael; Stepanyan, Stepan; Burkert, Volker; Sharabian, Youri

    1992-08-01

    Optical transmission, light output and time characteristics are given for long scintillator strips fabricated at the Yerevan Physics Institute using the extrusion method. It is shown that at 45% relative (to anthracene) light output, good transmission (2.5/2.9 m attenuation length with photomultiplier direct readout and 3/3.5 m attenuation length fiber readout) and time characteristics (average decay time 2.8 nsec) were obtained.

  15. Studies of NICADD Extruded Scintillator Strips

    SciTech Connect

    Dychkant, Alexandre; et al.

    2005-03-01

    About four hundred one meter long, 10 cm wide and 5 mm thick extruded scintillating strips were measured at four different points. The results of measurements strip responses to a radioactive source {sup 90}Sr are provided, and details of strip choice, preparation, and method of measurement are included. This work was essential for prototyping a tail catcher and muon tracker for a future international electron positron linear collider detector.

  16. Detecting dark matter with scintillating bubble chambers

    NASA Astrophysics Data System (ADS)

    Zhang, Jianjie; Dahl, C. Eric; Jin, Miaotianzi; Baxter, Daniel

    2016-03-01

    Threshold based direct WIMP dark matter detectors such as the superheated bubble chambers developed by the PICO experiment have demonstrated excellent electron-recoil and alpha discrimination, excellent scalability, ease of change of target fluid, and low cost. However, the nuclear-recoil like backgrounds have been a limiting factor in their dark matter sensitivity. We present a new type of detector, the scintillating bubble chamber, which reads out the scintillation pulse of the scattering events as well as the pressure, temperature, acoustic traces, and bubble images as a conventional bubble chamber does. The event energy provides additional handle to discriminate against the nuclear-recoil like backgrounds. Liquid xenon is chosen as the target fluid in our prototyping detector for its high scintillation yield and suitable vapor pressure which simplifies detector complexity. The detector can be used as an R&D tool to study the backgrounds present in the current PICO bubble chambers or as a prototype for standalone dark matter detectors in the future. Supported by DOE Grant DE-SC0012161.

  17. Calorimetry using organic scintillators, 'a sideways perspective'.

    SciTech Connect

    Proudfoot, J.

    1999-09-10

    Over the last two decades, calorimetry baaed on organic scintillators has developed into an excellent technology for many experimental situations in high energy physics. The primary difficulty, that of extracting the light signals, has benefited from two milestone innovations. The first was the use of wavelength-shifting bars to allow light to be efficiently collected from large areas of scintillator and then readily piped to a readout device. The second of these was the extension of this approach to plastic wavelength-shifting optical fibers whose great flexibility and small diameter allowed a minimum of detector volume to be compromised by the read-out. These two innovations coupled with inventiveness have produced many varied and successful calorimeters. Equal response to both hadronic and electromagnetic showers can be realized in scintillator-based calorimeters. However, in general this is not the case and it is likely that in the search for greater performance, in the future, combined tracking and calorimeter systems will be required.

  18. Boron-Loaded Silicone Rubber Scintillators

    SciTech Connect

    Bell, Z.W.; Maya, L.; Brown, G.M.; Sloop, F.V.Jr

    2003-05-12

    Silicone rubber received attention as an alternative to polyvinyltoluene in applications in which the scintillator is exposed to high doses because of the increased resistance of the rubber to the formation of blue-absorbing color centers. Work by Bowen, et al., and Harmon, et al., demonstrated their properties under gamma/x-ray irradiation, and Bell, et al. have shown their response to thermal neutrons. This last work, however, provided an example of a silicone in which both the boron and the scintillator were contained in the rubber as solutes, a formulation which led to the precipitation of solids and sublimation of the boron component. In the present work we describe a scintillator in which the boron is chemically bonded to the siloxane and so avoids the problem of precipitation and loss of boron to sublimation. Material containing up to 18% boron, by weight, was prepared, mounted on photomultipliers, and exposed to both neutron and gamma fluxes. Pulse height spectra showing the neutron and photon response were obtained, and although the light output was found to be much poorer than from samples in which boron was dissolved, the higher boron concentrations enabled essentially 100% neutron absorption in only a few millimeters' thickness of rubber.

  19. Scintillators with potential to supersede lanthanum bromide

    SciTech Connect

    Cherepy, Nerine; Payne, Steven; Aszatlos, Steve; Hull, Giulia; Kuntz, J.; Niedermayr, Tom; Pimputkar, S.; Roberts, J.; Sanner, R.; Tillotson, T.; van Loef, Edger; Wilson, Cody; Shah, Kanai; Roy, U.; Hawrami, R.; Burger, Arnold; Boatner, Lynn; Choong, Woon-Seng; Moses, William

    2009-06-01

    New scintillators for high-resolution gamma ray spectroscopy have been identified, grown and characterized. Our development efforts have focused on two classes of high light yield materials: Europium-doped alkaline earth halides and Cerium-doped garnets. Of the halide single crystals we have grown by the Bridgman method - SrI{sub 2}, CaI{sub 2}, SrBr{sub 2}, BaI{sub 2} and BaBr{sub 2} - SrI{sub 2} is the most promising. SrI{sub 2}(Eu) emits into the Eu{sup 2+} band, centered at 435 nm, with a decay time of 1.2 {micro}s and a light yield of up to 115,000 photons/MeV. It offers energy resolution better than 3% FWHM at 662 keV, and exhibits excellent light yield proportionality. Transparent ceramics fabrication allows production of Gadolinium- and Terbium-based garnets which are not growable by melt techniques due to phase instabilities. While scintillation light yields of Cerium-doped ceramic garnets are high, light yield non-proportionality and slow decay components appear to limit their prospects for high energy resolution. We are developing an understanding of the mechanisms underlying energy dependent scintillation light yield non-proportionality and how it affects energy resolution. We have also identified aspects of optical design that can be optimized to enhance energy resolution.

  20. Sillicon Photomultiplier and Scintillator Bar Systems

    NASA Astrophysics Data System (ADS)

    Shelor, Mark; Elizondo, Leonardo; Ritt, Stefan

    2016-03-01

    To analyze extraterrestrial cosmic rays via precise measurements of airshower axes directions of penetrating particles such as muons, we constructed a model detector consisting of two 1-meter long scintillator bars. Each bar is fitted with green wavelength shifting fibers to modulate input for two silicon photomultiplier (SiPM) light detectors to record light produced by cosmic rays via scintillation. The purpose of the experiment is to determine the performance of these devices. Two makes of SiPMs were evaluated - from AdvanSiD and Hamamatsu. In order to filter out noise, timing measurements of the apparatus were performed under several trigger conditions such as coincidence trigger with 2 photomultiplier detectors, as well as SiPM detector arrays in self-triggered mode. The DRS4 Digitizer 4-channel fast waveform sampler digitized SiPM detector waveforms. Signals were analyzed with the CERN PAW package. The speed of light in the scintillator using the SiPM modules was found to be approximately 66% of the speed of light in a vacuum which is in accordance with the index of refraction for the fibers given by the manufacturer's specifications. The results of our timing measurements would be presented. Dept. of Ed. Title V Grant PO31S090007.

  1. Pulse height model for deuterated scintillation detectors

    NASA Astrophysics Data System (ADS)

    Wang, Haitang; Enqvist, Andreas

    2015-12-01

    An analytical model of light pulse height distribution for finite deuterated scintillation detectors is created using the impulse approximation. Particularly, the energy distribution of a scattered neutron is calculated based on an existing collision probability scheme for general cylindrical shaped detectors considering double differential cross-sections. The light pulse height distribution is analytically and numerically calculated by convoluting collision sequences with the light output function for an EJ-315 detector from our measurements completed at Ohio University. The model provides a good description of collision histories capturing transferred neutron energy in deuterium-based scintillation materials. The resulting light pulse height distribution details pulse compositions and their corresponding contributions. It shows that probabilities of neutron collision with carbon and deuterium nuclei are comparable, however the light pulse amplitude due to collisions with carbon nuclei is small and mainly located at the lower region of the light pulse distribution axis. The model can explore those neutron interaction events that generate pulses near or below a threshold that would be imposed in measurements. A comparison is made between the light pulse height distributions given by the analytical model and measurements. It reveals a significant probability of a neutron generating a small light pulse due to collisions with carbon nuclei when compared to larger light pulse generated by collisions involving deuterium nuclei. This model is beneficial to understand responses of scintillation materials and pulse compositions, as well as nuclei information extraction from recorded pulses.

  2. Data-driven exploration of the ionization-phonon partitioning in scintillating radiation detector materials

    SciTech Connect

    Ferris, Kim F.; Webb-Robertson, Bobbie-Jo M.; Jordan, David V.; Jones, Dumont M.

    2008-06-01

    An information-based approach to scintillating materials development has been applied to ranking the alkali halide and alkali earth halide series in terms of their energy conversion efficiency. The efficiency of scintillating radiation detection materials can be viewed as the product of a consecutive series of electronic processes (energy conversion, transfer, and luminescence) as outlined by Lempicki and others. Relevant data are relatively sparse, but sufficient for the development of forward mapping of materials properties through materials signatures. These mappings have been used to explore the limits of the K ratio in the Lempicki model with chemical composition, and examine its relationship with another common design objective, density. The alkali halides and alkali earth halide compounds separate themselves into distinct behavior classes favoring heavier cations and anions for improved K ratio. While the coupling of ionization is strongly related to the optical phonon modes, both dielectric and band gap contributions cannot be ignored. When applied within a candidate screen, the resulting model for K imposes design rules—simple structural restrictions—on scintillating radiation detector materials.

  3. Neutron guide

    DOEpatents

    Greene, Geoffrey L.

    1999-01-01

    A neutron guide in which lengths of cylindrical glass tubing have rectangular glass plates properly dimensioned to allow insertion into the cylindrical glass tubing so that a sealed geometrically precise polygonal cross-section is formed in the cylindrical glass tubing. The neutron guide provides easier alignment between adjacent sections than do the neutron guides of the prior art.

  4. Characterization of Ionospheric Scintillation Using Simultaneous Formosat-3/COSMIC Radio Occultation Observations and AFRL SCINDA Ground Scintillation Measurements

    NASA Astrophysics Data System (ADS)

    Starks, M. J.; Lin, C. S.; Groves, K. M.; Pedersen, T. R.; Basu, S.; Syndergaard, S.; Rocken, C.

    2007-05-01

    Ionospheric scintillation at low latitudes has been studied using ionospheric radio occultation (RO) measurements by the FORMOSAT-3/COSMIC micro-satellites in conjunction with ground-based data from the Scintillation Network Decision Aid (SCINDA) station at Kwajalein Atoll. The Air Force Research Laboratory has developed the SCINDA network for monitoring low-latitude ionospheric total electron content (TEC) and scintillation associated with equatorial spread F. The network currently consists of sixteen stations distributed around the globe and the data have been used to conduct numerous studies on the characteristics and climatology of equatorial scintillation. The present study focuses on COSMIC RO and SCINDA data during the three COSMIC campaigns in 2006. Radio occultation events are selected by requiring that ionospheric scintillation was detected by the SCINDA VHF scintillation monitor at Kwajalein, and that the occultation ray path intersected the Kwajalein longitude below the satellite altitude, which varied from 500 to 800 km for the six FORMOSAT-3 satellites. In order to exclude tropospheric effects, only GPS signal amplitudes from FORMOSAT-3 with ray path tangent altitudes above 100 km are considered. Locations of ionospheric scintillation are estimated by triangulation using the satellites and the SCINDA ground station. Airglow images at Kwajalein are also used to confirm occurrence of equatorial ionospheric scintillations. For the selected events, large amplitude L1 and L2 scintillations tend to occur at altitudes below 200 km at frequencies around 0.5 Hz. The results are discussed as a potential path toward better specifying the occurrence of equatorial scintillations.

  5. Separation of scintillation and Cherenkov lights in linear alkyl benzene

    NASA Astrophysics Data System (ADS)

    Li, Mohan; Guo, Ziyi; Yeh, Minfang; Wang, Zhe; Chen, Shaomin

    2016-09-01

    To separate scintillation and Cherenkov lights in water-based liquid scintillator detectors is a desired feature for future neutrino and proton decay experiments. Linear alkyl benzene (LAB) is one important ingredient of a water-based liquid scintillator currently under development. In this paper we report on the separation of scintillation and Cherenkov lights observed in an LAB sample. The rise and decay times of the scintillation light are measured to be (7.7 ± 3.0) ns and (36.6 ± 2.4) ns , respectively, while the full width [-3σ, 3σ] of the Cherenkov light is 12 ns and is dominated by the time resolution of the photomultiplier tubes. The scintillation light yield was measured to be (1.01 ± 0.12) ×103 photons / MeV .

  6. Light collection from scintillation counters using WLS fibers and bars

    SciTech Connect

    Evdokimov, V.

    1998-01-01

    Several methods of collecting light on scintillation counters using WLS fibers and WLS bars were studied. Nearly 20 prototype counters with different designs and with sizes ranging from 14{times}11{times}1.3cm{sup 3} to 105{times}60{times}1.3cm{sup 3} have been tested using cosmic muons and radioactive source. The efficiency of light collection on number of photoelectrons, uniformity of response, and time resolution have been measured. Test results for two new designs of light collection from scintillator based on WLS fibers around perimeter of scintillator plate and WLS fibers placed in machined on scintillator plate deep grooves are presented. Two out of the studied designs have been chosen as the basic options for the D0 muon system upgrade: light collection using two WLS bars for the forward muon scintillation counters and light collection using WLS fibers in deep grooves on scintillator for central area muon counters.

  7. Metal-loaded organic scintillators for neutrino physics

    NASA Astrophysics Data System (ADS)

    Buck, Christian; Yeh, Minfang

    2016-09-01

    Organic liquid scintillators are used in many neutrino physics experiments of the past and present. In particular for low energy neutrinos when realtime and energy information are required, liquid scintillators have several advantages compared to other technologies. In many cases the organic liquid needs to be loaded with metal to enhance the neutrino signal over background events. Several metal loaded scintillators of the past suffered from chemical and optical instabilities, limiting the performance of these neutrino detectors. Different ways of metal loading are described in the article with a focus on recent techniques providing metal loaded scintillators that can be used under stable conditions for many years even in ton scale experiments. Applications of metal loaded scintillators in neutrino experiments are reviewed and the performance as well as the prospects of different scintillator types are compared.

  8. Methods for the continuous production of plastic scintillator materials

    DOEpatents

    Bross, Alan; Pla-Dalmau, Anna; Mellott, Kerry

    1999-10-19

    Methods for producing plastic scintillating material employing either two major steps (tumble-mix) or a single major step (inline-coloring or inline-doping). Using the two step method, the polymer pellets are mixed with silicone oil, and the mixture is then tumble mixed with the dopants necessary to yield the proper response from the scintillator material. The mixture is then placed in a compounder and compounded in an inert gas atmosphere. The resultant scintillator material is then extruded and pelletized or formed. When only a single step is employed, the polymer pellets and dopants are metered into an inline-coloring extruding system. The mixture is then processed under a inert gas atmosphere, usually argon or nitrogen, to form plastic scintillator material in the form of either scintillator pellets, for subsequent processing, or as material in the direct formation of the final scintillator shape or form.

  9. Theoretical Studies of the Optical Properties of Eu doped Barium Mixed Halides: From X-ray Storage Phosphor to Bright Scintillator

    NASA Astrophysics Data System (ADS)

    Chourou, Slim; Bizarri, Gregory; Canning, Andrew

    2015-03-01

    The Eu doped Ba mixed halide family BaBrX (X=F,Cl,Br,I) changes from being a widely used X-ray Storage Phosphor (BaBrF:Eu) to one of the brightest know new gamma ray detector scintillators (BaBrI:Eu). To help understand these contrasting optical properties and guide in the design of new and improved scintillator detectors, in collaboration with experimental groups, we have performed first principles theoretical studies of these materials. In particular we have studied their electron and hole trapping mechanisms and how that can explain their very different optical properties.

  10. Get Screened

    MedlinePlus

    ... Get Ready 3 of 4 sections Take Action: Cost and Insurance What about cost? Depending on your insurance plan, you may be able to get screening tests at no cost to you. Most insurance plans, including Medicaid and ...

  11. TORCH screen

    MedlinePlus

    ... different infections in a newborn. TORCH stands for toxoplasmosis , rubella , cytomegalovirus, herpes simplex, and HIV, but it ... used to screen infants for infections such as toxoplasmosis, cytomegalovirus, herpes simplex, syphilis and others. These infections ...

  12. Developmental Screening

    MedlinePlus

    Learn More about Your Child’s Development: Developmental Monitoring and Screening Taking a first step, waving “bye-bye,” and pointing to something interesting are all developmental milestones, ...

  13. Hypertension screening

    NASA Technical Reports Server (NTRS)

    Foulke, J. M.

    1975-01-01

    An attempt was made to measure the response to an announcement of hypertension screening at the Goddard Space Center, to compare the results to those of previous statistics. Education and patient awareness of the problem were stressed.

  14. TORCH Screen

    MedlinePlus

    ... different infections in a newborn. TORCH stands for toxoplasmosis , rubella , cytomegalovirus, herpes simplex, and HIV, but it ... used to screen infants for infections such as toxoplasmosis, cytomegalovirus, herpes simplex, syphilis and others. These infections ...

  15. Newborn Screening

    MedlinePlus

    ... Pulse Oximetry Screening for CCHDs Sickle Cell Disease Laboratory SCID Quality Assurance Training and Resources For Lab Professionals Data and Reports Laboratory Reports National Birth Defects Prevention Network (NBDPN) Resources ...

  16. Measurement accuracy and Cerenkov removal for high performance, high spatial resolution scintillation dosimetry

    SciTech Connect

    Archambault, Louis; Beddar, A. Sam; Gingras, Luc

    2006-01-15

    With highly conformal radiation therapy techniques such as intensity-modulated radiation therapy, radiosurgery, and tomotherapy becoming more common in clinical practice, the use of these narrow beams requires a higher level of precision in quality assurance and dosimetry. Plastic scintillators with their water equivalence, energy independence, and dose rate linearity have been shown to possess excellent qualities that suit the most complex and demanding radiation therapy treatment plans. The primary disadvantage of plastic scintillators is the presence of Cerenkov radiation generated in the light guide, which results in an undesired stem effect. Several techniques have been proposed to minimize this effect. In this study, we compared three such techniques--background subtraction, simple filtering, and chromatic removal--in terms of reproducibility and dose accuracy as gauges of their ability to remove the Cerenkov stem effect from the dose signal. The dosimeter used in this study comprised a 6-mm{sup 3} plastic scintillating fiber probe, an optical fiber, and a color charge-coupled device camera. The whole system was shown to be linear and the total light collected by the camera was reproducible to within 0.31% for 5-s integration time. Background subtraction and chromatic removal were both found to be suitable for precise dose evaluation, with average absolute dose discrepancies of 0.52% and 0.67%, respectively, from ion chamber values. Background subtraction required two optical fibers, but chromatic removal used only one, thereby preventing possible measurement artifacts when a strong dose gradient was perpendicular to the optical fiber. Our findings showed that a plastic scintillation dosimeter could be made free of the effect of Cerenkov radiation.

  17. Predicting the timing properties of phosphor-coated scintillators using Monte Carlo light transport simulation.

    PubMed

    Roncali, Emilie; Schmall, Jeffrey P; Viswanath, Varsha; Berg, Eric; Cherry, Simon R

    2014-04-21

    Current developments in positron emission tomography focus on improving timing performance for scanners with time-of-flight (TOF) capability, and incorporating depth-of-interaction (DOI) information. Recent studies have shown that incorporating DOI correction in TOF detectors can improve timing resolution, and that DOI also becomes more important in long axial field-of-view scanners. We have previously reported the development of DOI-encoding detectors using phosphor-coated scintillation crystals; here we study the timing properties of those crystals to assess the feasibility of providing some level of DOI information without significantly degrading the timing performance. We used Monte Carlo simulations to provide a detailed understanding of light transport in phosphor-coated crystals which cannot be fully characterized experimentally. Our simulations used a custom reflectance model based on 3D crystal surface measurements. Lutetium oxyorthosilicate crystals were simulated with a phosphor coating in contact with the scintillator surfaces and an external diffuse reflector (teflon). Light output, energy resolution, and pulse shape showed excellent agreement with experimental data obtained on 3 × 3 × 10 mm³ crystals coupled to a photomultiplier tube. Scintillator intrinsic timing resolution was simulated with head-on and side-on configurations, confirming the trends observed experimentally. These results indicate that the model may be used to predict timing properties in phosphor-coated crystals and guide the coating for optimal DOI resolution/timing performance trade-off for a given crystal geometry. Simulation data suggested that a time stamp generated from early photoelectrons minimizes degradation of the timing resolution, thus making this method potentially more useful for TOF-DOI detectors than our initial experiments suggested. Finally, this approach could easily be extended to the study of timing properties in other scintillation crystals, with a range of

  18. Ionospheric scintillation in Brazil: Analyses and Effects on GNSS Positioning

    NASA Astrophysics Data System (ADS)

    Alves, D. B.; Souza, J. S.; Silva, H. D.

    2013-05-01

    Ionosphere has a great influence on GNSS (Global Navigation Satellite System) signals and its behavior depends on several variables: local time, geographic location, seasons and solar activity. Besides, there are ionospheric irregularities that also affect the GNSS signal propagation, as the ionospheric scintillation. The ionospheric scintillation can be described as a fast change in phase and amplitude of GNSS signal, caused by irregularities of electron density. Scintillation can degrade or cause the GNSS signal lost. Due to these described factors, one can say that the ionosphere can cause important effects on GNSS positioning. It can degrade the coordinate accuracy obtained by GNSS positioning methods. In this paper the goal is to evaluate the ionospheric effect, in special the ionospheric scintillation in different regions of Brazil, and its effects on GNSS Point Positioning. In order to evaluate the days where the scintillation was more significant it is used a database (http://200.145.185.118/cigala/index.php) from CIGALA (Concept for Ionospheric Scintillation Mitigation for Professional GNSS in Latin America) project (http://cigala.galileoic.org/). Using these data it is possible to obtain information about ionospheric scintillation in different GNSS stations in Brazil. It is possible to correlate the data according to time, season and other factors that can contribute to scintillation analysis. In 2013 must occur an intense solar activity, which can intensify the ionospheric effects, and consequently ionospheric scintillation, mainly in Brazil region, where the scintillation index is already intense. Preliminary evaluations, showed larger values of S4 (scintillation index) in Brazil. For example, in October 2012, it was obtained S4 values larger than 1 in several epochs. This causes severe effects in GNSS Positioning. In this paper, the results of GNSS positioning under ionosphere scintillation effects in different regions of Brazil will be presented.

  19. Transition effect of air shower particles in plastic scintillators

    NASA Technical Reports Server (NTRS)

    Asakimori, K.; Maeda, T.; Kameda, T.; Mizushima, K.; Misaki, Y.

    1985-01-01

    The transition effect of air shower particles in the plastic scintillators near the core was measured by scintillators of various thickness. The air showers selected for the measurement were of 10,000. Results obtained are as follows: (1) the multiplication of shower particles in the scintillators is less than 20% for that of 50 mm thickness; (2) dependence of the transition effect on age parameter is not recognized within the experimental errors.

  20. Growth and scintillation properties of gadolinium and yttrium orthovanadate crystals

    NASA Astrophysics Data System (ADS)

    Voloshina, O. V.; Baumer, V. N.; Bondar, V. G.; Kurtsev, D. A.; Gorbacheva, T. E.; Zenya, I. M.; Zhukov, A. V.; Sidletskiy, O. Ts.

    2012-02-01

    Aiming to explore the possibility of using the undoped rare-earth orthovanadates as scintillation materials, we developed the procedure for growth of gadolinium (GdVO 4) and yttrium (YVO 4) orthovanadate single crystals by Czochralski method, and determined the optimal conditions of their after-growth annealing. Optical, luminescent, and scintillation properties of YVO 4 and GdVO 4 were discussed versus known literature data. Scintillation characteristics of GdVO 4 were determined for the first time.

  1. Composite solid-state scintillators for neutron detection

    DOEpatents

    Dai, Sheng; Im, Hee-Jung; Pawel, Michelle D.

    2006-09-12

    Applicant's present invention is a composite scintillator for neutron detection comprising a matrix material fabricated from an inorganic sol-gel precursor solution homogeneously doped with a liquid scintillating material and a neutron absorbing material. The neutron absorbing material yields at least one of an electron, a proton, a triton, an alpha particle or a fission fragment when the neutron absorbing material absorbs a neutron. The composite scintillator further comprises a liquid scintillating material in a self-assembled micelle formation homogeneously doped in the matrix material through the formation of surfactant-silica composites. The scintillating material is provided to scintillate when traversed by at least one of an electron, a proton, a triton, an alpha particle or a fission fragment. The scintillating material is configured such that the matrix material surrounds the micelle formation of the scintillating material. The composite scintillator is fabricated and applied as a thin film on substrate surfaces, a coating on optical fibers or as a glass material.

  2. Plasmonic light yield enhancement of a liquid scintillator

    SciTech Connect

    Bignell, Lindsey J.; Jackson, Timothy W.; Mume, Eskender; Lee, George P.

    2013-05-27

    We demonstrate modifications to the light yield properties of an organic liquid scintillator due to the localization of the tertiary fluorophore component to the surface of Ag-core silica-shell nanoparticles. We attribute this enhancement to the near-field interaction of Ag nanoparticle plasmons with these fluor molecules. The scintillation light yield enhancement is shown to be equal to the fluorescence enhancement within measurement uncertainties. With a suitable choice of plasmon energy and scintillation fluor, this effect may be used to engineer scintillators with enhanced light yields for radiation detection applications.

  3. Large-scale liquid scintillation detectors for solar neutrinos

    NASA Astrophysics Data System (ADS)

    Benziger, Jay B.; Calaprice, Frank P.

    2016-04-01

    Large-scale liquid scintillation detectors are capable of providing spectral yields of the low energy solar neutrinos. These detectors require > 100 tons of liquid scintillator with high optical and radiopurity. In this paper requirements for low-energy neutrino detection by liquid scintillation are specified and the procedures to achieve low backgrounds in large-scale liquid scintillation detectors for solar neutrinos are reviewed. The designs, operations and achievements of Borexino, KamLAND and SNO+ in measuring the low-energy solar neutrino fluxes are reviewed.

  4. Plasmonic light yield enhancement of a liquid scintillator

    NASA Astrophysics Data System (ADS)

    Bignell, Lindsey J.; Mume, Eskender; Jackson, Timothy W.; Lee, George P.

    2013-05-01

    We demonstrate modifications to the light yield properties of an organic liquid scintillator due to the localization of the tertiary fluorophore component to the surface of Ag-core silica-shell nanoparticles. We attribute this enhancement to the near-field interaction of Ag nanoparticle plasmons with these fluor molecules. The scintillation light yield enhancement is shown to be equal to the fluorescence enhancement within measurement uncertainties. With a suitable choice of plasmon energy and scintillation fluor, this effect may be used to engineer scintillators with enhanced light yields for radiation detection applications.

  5. Development of polystyrene-based scintillation materials and its mechanisms

    NASA Astrophysics Data System (ADS)

    Nakamura, Hidehito; Kitamura, Hisashi; Shinji, Osamu; Saito, Katashi; Shirakawa, Yoshiyuki; Takahashi, Sentaro

    2012-12-01

    Scintillation materials based on polystyrene (PS) have been investigated. Para-terphenyl was employed as a fluorescent molecule (fluor) that functions as a wavelength shifter. A clear increase in photon yield of the scintillation materials relative to the pure PS was observed, which cannot be explained by the conventional theory of scintillation mechanism. Furthermore, the photon yield increased with flour concentration in accordance with a power-law. Here we reveal the emergence of a luminescence of PS-based scintillation materials and demonstrate that their photon yields can be controlled by the fluor concentration.

  6. Lanthanide doped strontium-barium cesium halide scintillators

    SciTech Connect

    Bizarri, Gregory; Bourret-Courchesne, Edith; Derenzo, Stephen E.; Borade, Ramesh B.; Gundiah, Gautam; Yan, Zewu; Hanrahan, Stephen M.; Chaudhry, Anurag; Canning, Andrew

    2015-06-09

    The present invention provides for a composition comprising an inorganic scintillator comprising an optionally lanthanide-doped strontium-barium, optionally cesium, halide, useful for detecting nuclear material.

  7. Energy Transfer Based Nanocomposite Scintillator for Radiation Detection

    NASA Astrophysics Data System (ADS)

    Aslam, Soha; Sahi, Sunil; Chen, Wei; Ma, Lun; Kenarangui, Rasool

    2014-09-01

    Scintillators are the materials that emit light upon irradiation with high energy radiation like X-ray or gamma-ray. Inorganic single crystal and organic (plastic and liquid) are the two most used scintillator types. Both of these scintillator kinds have advantages and disadvantages. Inorganic single crystals are expensive and difficult to grow in desire shape and size. Also, single crystal scintillator such as NaI and CsI are very hygroscopic. On the other hand, organic scintillators have low density which limits their applications in gamma spectroscopy. Due to high quantum yield and size dependent emission, nanoparticles have attracted interested in various field of research. Here, we have studies the nanoparticles for radiation detection. We have synthesized nanoparticles of Cerium fluoride (CeF3), Zinc Oxide (ZnO), Cadmium Telluride (CdTe), Copper complex and Zinc sulfide (ZnS). We have used Fluorescence Resonance Energy Transfer (FRET) principle to enhance the luminescence properties of nanocomposite scintillator. Nanocomposites scintillators are structurally characterized with X-ray diffraction (XRD) and Transmission Electron Microscopy (TEM). Optical properties are studied using Photoluminescence, UV-Visible and X-ray. Enhancements in the luminescence are observed under UV and X-ray excitation. Preliminary studies shows nanocomposite scintillators are promising for radiation detection. Scintillators are the materials that emit light upon irradiation with high energy radiation like X-ray or gamma-ray. Inorganic single crystal and organic (plastic and liquid) are the two most used scintillator types. Both of these scintillator kinds have advantages and disadvantages. Inorganic single crystals are expensive and difficult to grow in desire shape and size. Also, single crystal scintillator such as NaI and CsI are very hygroscopic. On the other hand, organic scintillators have low density which limits their applications in gamma spectroscopy. Due to high quantum

  8. Scintillation near the F-layer trough over Northern Europe

    SciTech Connect

    Kersley, L.; Pryse, S.E.; Russell, C.D.

    1990-05-03

    Results are presented of scintillation observations made during a two and a half year period at Lerwick in the Shetland Islands using more than 19000 passes of NNSS satellites. Examples of scintillation morphology, in the region near the scintillation boundary and the F-layer trough, for both amplitude and phase are discussed using exceedence levels for the S sub 4 and sigma sub psi indices respectively. The equatorwards advancement of the scintillation boundary in response to enhanced solar activity during the increasing phase of the solar cycle is shown to be a dominant feature in the observations.

  9. Chaotic behavior of ionospheric turbulence from scintillation measurements

    SciTech Connect

    Bhattacharyya, A. )

    1990-05-01

    Ionospheric amplitude and phase scintillation data have been analyzed to estimate the information dimension associated with the attractor of the system. For weak scintillations, both amplitude and phase data yield identical results which demonstrate that spatial fluctuations of electron density in the ionosphere may be characterized by a few degrees of freedom. Stronger scintillations are attributed to steepened density irregularities which cause focusing of the incident radio wave. This results in the amplitude scintillations exhibiting higher dimensional chaos but spatial fluctuations in ionospheric density still involve low dimensional chaos.

  10. Application of accelerators for the research and development of scintillators.

    PubMed

    Shibuya, Kengo; Koshimizu, Masanori; Asai, Keisuke; Muroya, Yusa; Katsumura, Yosuke; Inadama, Naoko; Yoshida, Eiji; Nishikido, Fumihiko; Yamaya, Taiga; Murayama, Hideo

    2007-08-01

    We introduce experimental systems which use accelerators to evaluate scintillation properties such as scintillation intensity, wavelength, and lifetime. A single crystal of good optical quality is often unavailable during early stages in the research and development (R&D) of new scintillator materials. Because of their beams' high excitation power and/or low penetration depth, accelerators facilitate estimation of the properties of early samples which may only be available as powders, thin films, and very small crystals. We constructed a scintillation spectrum measurement system that uses a Van de Graaff accelerator and an optical multichannel analyzer to estimate the relative scintillation intensity. In addition, we constructed a scintillation time profile measurement system that uses an electron linear accelerator and a femtosecond streak camera or a microchannel plate photomultiplier tube followed by a digital oscilloscope to determine the scintillation lifetimes. The time resolution is approximately 10 ps. The scintillation spectra or time profiles can be obtained in a significantly shorter acquisition time in comparison with that required by conventional measuring systems. The advantages of the systems described in this study can significantly promote the R&D of novel scintillator materials. PMID:17764319

  11. A slanting light-guide analog decoding high resolution detector for positron emission tomography camera

    SciTech Connect

    Wong, W.H.; Jing, M.; Bendriem, B.; Hartz, R.; Mullani, N.; Gould, K.L.; Michel, C.

    1987-02-01

    Current high resolution PET cameras require the scintillation crystals to be much narrower than the smallest available photomultipliers. In addition, the large number of photomultiplier channels constitutes the major component cost in the camera. Recent new designs use the Anger camera type of analog decoding method to obtain higher resolution and lower cost by using the relatively large photomultipliers. An alternative approach to improve the resolution and cost factors has been proposed, with a system of slanting light-guides between the scintillators and the photomultipliers. In the Anger camera schemes, the scintillation light is distributed to several neighboring photomultipliers which then determine the scintillation location. In the slanting light-guide design, the scintillation is metered and channeled to only two photomultipliers for the decision making. This paper presents the feasibility and performance achievable with the slanting light-guide detectors. With a crystal/photomultiplier ratio of 6/1, the intrinsic resolution was found to be 4.0 mm using the first non-optimized prototype light-guides on BGO crystals. The axial resolution will be about 5-6 mm.

  12. A Guide to Desktop Videoconferencing.

    ERIC Educational Resources Information Center

    Maring, Gerald H.; Levy, Erik W.

    This document presents a step-by-step guide to using three desktop videoconferencing applications: CU-SeeMe, iVisit, and NetMeeting. First, hardware and software recommendations for PC-based and Macintosh systems are provided. Illustrations of sample screens accompany the text for each application. The following additional considerations for…

  13. Apparatus for positioning an external radioactive standard in a liquid scintillation counter

    SciTech Connect

    Horrocks, D.L.; Kampf, R.S.

    1987-07-07

    This patent describes a liquid scintillation counter having a counting chamber for receiving a sample containing a scintillator substance and a sample of a radioactive substance to be counted. The improved apparatus positions a radioactive source in an operating location to irradiate the sample in the counting chamber comprising, in combination: (1) a continuous bidirectionally flexible conveyor forming a closed loop for conveying the radioactive source through on operating location and a storage location; (2) means supporting the radioactive source at a position along the flexible conveyor for conveyance; (3) guide means for supporting the conveyor and for guiding conveyor movement along a selected path, the path transversing at spaced positions the storage location for the radioactive source remote from the counting chamber and the operating location for the radioactive source near to the counting chamber; and (4) drive means coupled to the continuous flexible conveyor to draw the conveyor around the path for conveying the radioactive source through the spaced storage and operating locations.

  14. A model for the secondary scintillation pulse shape from a gas proportional scintillation counter

    NASA Astrophysics Data System (ADS)

    Kazkaz, K.; Joshi, T. H.

    2016-03-01

    Proportional scintillation counters (PSCs), both single- and dual-phase, can measure the scintillation (S1) and ionization (S2) channels from particle interactions within the detector volume. The signal obtained from these detectors depends first on the physics of the medium (the initial scintillation and ionization), and second how the physics of the detector manipulates the resulting photons and liberated electrons. In this paper we develop a model of the detector physics that incorporates event topology, detector geometry, electric field configuration, purity, optical properties of components, and wavelength shifters. We present an analytic form of the model, which allows for general study of detector design and operation, and a Monte Carlo model which enables a more detailed exploration of S2 events. This model may be used to study systematic effects in current detectors such as energy and position reconstruction, pulse shape discrimination, event topology, dead time calculations, purity, and electric field uniformity. We present a comparison of this model with experimental data collected with an argon gas proportional scintillation counter (GPSC), operated at 20 C and 1 bar, and irradiated with an internal, collimated 55Fe source. Additionally we discuss how the model may be incorporated in Monte Carlo simulations of both GPSCs and dual-phase detectors, increasing the reliability of the simulation results and allowing for tests of the experimental data analysis algorithms.

  15. Comparing the response of PSD-capable plastic scintillator to standard liquid scintillator

    NASA Astrophysics Data System (ADS)

    Woolf, Richard S.; Hutcheson, Anthony L.; Gwon, Chul; Phlips, Bernard F.; Wulf, Eric A.

    2015-06-01

    This work discusses a test campaign to characterize the response of the recently developed plastic scintillator with pulse shape discrimination (PSD) capabilities (EJ-299-33). PSD is a property exhibited by certain types of scintillating material in which incident stimuli (fast neutrons or γ rays) can be separated by exploiting differences in the scintillation light pulse tail. Detector geometries used were: a 10 cm×10 cm×10 cm cube and a 10-cm diameter×10-cm long cylinder. EJ-301 and EJ-309 liquid scintillators with well-known responses were also tested. The work was conducted at the University of Massachusetts Lowell Van De Graaff accelerator. The facility accelerated protons on a thin Li target to yield quasi-monoenergetic neutrons from the 7Li(p,n)7Be reaction (Q-value: -1.644 MeV). Collimated fast neutrons were obtained by placing detectors behind a neutron spectrometer. Rotating the spectrometer, and thus changing the neutron energy, allowed us to achieve 0.5-3.2 MeV neutrons in 200-300 keV steps. Data were acquired through a flash analog-to-digital converter (ADC) capable of performing digital PSD measurements. By using the PSD technique to separate the neutron events from unwanted γ background, we constructed a pulse height spectrum at each energy. Obtaining a relationship of the relative light output versus energy allowed us to construct the response function for the EJ-299-33 and liquid scintillator. The EJ-299-33 response in terms of electron equivalent energy (Ee.e.) vs. proton equivalent energy (Ep.e.), how it compared with the standard xylene-based EJ-301 (or, NE-213/BC-501 A equivalent) and EJ-309 liquid scintillator response, and how the EJ-301 and EJ-309 compared, are presented. We find that the EJ-299-33 demonstrated a lower light output by up to 40% for <1.0 MeV neutrons; and ranging between a 5-35% reduction for 2.5-3.0 MeV neutrons compared to the EJ-301/309, depending on the scintillator and geometry. Monte Carlo modeling techniques were

  16. HF produced ionospheric electron density irregularities diagnosed by UHF radio star scintillations

    SciTech Connect

    Alfred, F.

    1982-01-01

    HF-waves incident on an overdense (HF-frequency < penetration frequency) ionosphere are known to produce large scale electron density irregularities. It is predicted that similar irregularities are formed during underdense HF-modification. The propagation of UHF radio waves originating from radio stars will be affected by such irregularities in the ionosphere. The interest in a scintillation experiment is twofold. One may obtain information on the electron density irregularies and one may learn about the propagation of radio waves through such a perturbed medium. A thin screen (diffractive) theory is derived which allows to draw conclusons on the electron density irregularities from the intensity fluctuations measured on the ground if the phase perturbations are much less than one radian. Since radio stars suitable for scintillation measurements at UHF are very faint an antenna with a large collection area is required. The observations reported in this dissertation were performed with the 300m diameter spherical reflector of the Arecibo Observatory. Successful observations were performed at 430 MHz and at 1400 MHz. Intensity fluctuations at such high frequencies measured with a large antenna suffer severe filtering in the thin phase screen regime. The theory presented in this dissertation includes these filtering effects. Many observations agree with the predictions of that theory. Some observations indicate that refraction effects have to be included to explain the data. HF-induced electron density irregularities were only observed during overdense heating.

  17. RNAi Screening in Spodoptera frugiperda.

    PubMed

    Ghosh, Subhanita; Singh, Gatikrushna; Sachdev, Bindiya; Kumar, Ajit; Malhotra, Pawan; Mukherjee, Sunil K; Bhatnagar, Raj K

    2016-01-01

    RNA interference is a potent and precise reverse genetic approach to carryout large-scale functional genomic studies in a given organism. During the past decade, RNAi has also emerged as an important investigative tool to understand the process of viral pathogenesis. Our laboratory has successfully generated transgenic reporter and RNAi sensor line of Spodoptera frugiperda (Sf21) cells and developed a reversal of silencing assay via siRNA or shRNA guided screening to investigate RNAi factors or viral pathogenic factors with extraordinary fidelity. Here we describe empirical approaches and conceptual understanding to execute successful RNAi screening in Spodoptera frugiperda 21-cell line. PMID:27581295

  18. Direct reading measurement of absorbed dose with plastic scintillators--the general concept and applications to ophthalmic plaque dosimetry.

    PubMed

    Flühs, D; Heintz, M; Indenkämpen, F; Wieczorek, C

    1996-03-01

    We have developed dosemeters based on plastic scintillators for a variety of applications in radiation therapy. The dosemeters consist basically of a tissue-substituting scintillator probe, an optical fiber light guide, and a photomultiplier tube. The background light generated in the light guide can be compensated by a simultaneous measurement of the light from a blind fiber. Plastic scintillator dosemeters combine several advantageous properties which render them superior to other dosemeter types for many applications: minimal disturbance of the radiation field because of the homogeneous detector volume and the approximate water equivalence; no dependence on temperature and pressure (under standard clinical conditions) and angle of radiation incidence; no high voltage in the probe; high spatial resolution due to small detector volumes; direct reading of absorbed doses; and a large dynamical range. The high spatial resolution together with direct reading make these detectors suitable for real-time 3-D dosimetry using multi-channel detector systems. Such a system has been developed for eye plaque dosimetry and successfully employed for dosimetric treatment optimization. The plaque optimization can be performed by dosimetric measurements for the individual patient ("dosimetric treatment planning"). The time consumption for this procedure is less than for a physically correct computer-based therapy planning, e.g., by means of a Monte Carlo simulation. PMID:8815386

  19. Cherenkov and Scintillation Properties of Cubic Zirconium

    NASA Technical Reports Server (NTRS)

    Christl, M.J.; Adams, J.H.; Parnell, T.A.; Kuznetsov, E.N.

    2008-01-01

    Cubic zirconium (CZ) is a high index of refraction (n =2.17) material that we have investigated for Cherenkov counter applications. Laboratory and proton accelerator tests of an 18cc sample of CZ show that the expected fast Cherenkov response is accompanied by a longer scintillation component that can be separated by pulse shaping. This presents the possibility of novel particle spectrometers which exploits both properties of CZ. Other high index materials being examined for Cherenkov applications will be discussed. Results from laboratory tests and an accelerator exposure will be presented and a potential application in solar energetic particle instruments will be discussed

  20. Fundamental Limits of Scintillation Detector Timing Precision

    PubMed Central

    Derenzo, Stephen E.; Choong, Woon-Seng; Moses, William W.

    2014-01-01

    In this paper we review the primary factors that affect the timing precision of a scintillation detector. Monte Carlo calculations were performed to explore the dependence of the timing precision on the number of photoelectrons, the scintillator decay and rise times, the depth of interaction uncertainty, the time dispersion of the optical photons (modeled as an exponential decay), the photodetector rise time and transit time jitter, the leading-edge trigger level, and electronic noise. The Monte Carlo code was used to estimate the practical limits on the timing precision for an energy deposition of 511 keV in 3 mm × 3 mm × 30 mm Lu2SiO5:Ce and LaBr3:Ce crystals. The calculated timing precisions are consistent with the best experimental literature values. We then calculated the timing precision for 820 cases that sampled scintillator rise times from 0 to 1.0 ns, photon dispersion times from 0 to 0.2 ns, photodetector time jitters from 0 to 0.5 ns fwhm, and A from 10 to 10,000 photoelectrons per ns decay time. Since the timing precision R was found to depend on A−1/2 more than any other factor, we tabulated the parameter B, where R = BA−1/2. An empirical analytical formula was found that fit the tabulated values of B with an rms deviation of 2.2% of the value of B. The theoretical lower bound of the timing precision was calculated for the example of 0.5 ns rise time, 0.1 ns photon dispersion, and 0.2 ns fwhm photodetector time jitter. The lower bound was at most 15% lower than leading-edge timing discrimination for A from 10 to 10,000 photoelectrons/ns. A timing precision of 8 ps fwhm should be possible for an energy deposition of 511 keV using currently available photodetectors if a theoretically possible scintillator were developed that could produce 10,000 photoelectrons/ns. PMID:24874216

  1. Fundamental limits of scintillation detector timing precision.

    PubMed

    Derenzo, Stephen E; Choong, Woon-Seng; Moses, William W

    2014-07-01

    In this paper we review the primary factors that affect the timing precision of a scintillation detector. Monte Carlo calculations were performed to explore the dependence of the timing precision on the number of photoelectrons, the scintillator decay and rise times, the depth of interaction uncertainty, the time dispersion of the optical photons (modeled as an exponential decay), the photodetector rise time and transit time jitter, the leading-edge trigger level, and electronic noise. The Monte Carlo code was used to estimate the practical limits on the timing precision for an energy deposition of 511 keV in 3 mm × 3 mm × 30 mm Lu2SiO5:Ce and LaBr3:Ce crystals. The calculated timing precisions are consistent with the best experimental literature values. We then calculated the timing precision for 820 cases that sampled scintillator rise times from 0 to 1.0 ns, photon dispersion times from 0 to 0.2 ns, photodetector time jitters from 0 to 0.5 ns fwhm, and A from 10 to 10,000 photoelectrons per ns decay time. Since the timing precision R was found to depend on A(-1/2) more than any other factor, we tabulated the parameter B, where R = BA(-1/2). An empirical analytical formula was found that fit the tabulated values of B with an rms deviation of 2.2% of the value of B. The theoretical lower bound of the timing precision was calculated for the example of 0.5 ns rise time, 0.1 ns photon dispersion, and 0.2 ns fwhm photodetector time jitter. The lower bound was at most 15% lower than leading-edge timing discrimination for A from 10 to 10,000 photoelectrons ns(-1). A timing precision of 8 ps fwhm should be possible for an energy deposition of 511 keV using currently available photodetectors if a theoretically possible scintillator were developed that could produce 10,000 photoelectrons ns(-1). PMID:24874216

  2. Colon cancer screening

    MedlinePlus

    ... screening; Sigmoidoscopy - screening; Virtual colonoscopy - screening; Fecal immunochemical test; Stool DNA test; sDNA test ... death and complications caused by colorectal cancer. SCREENING TESTS There are several ways to screen for colon ...

  3. Measurement of Scintillation and Ionization Yield and Scintillation Pulse Shape from Nuclear Recoils in Liquid Argon

    SciTech Connect

    Cao, H.

    2015-05-26

    We have measured the scintillation and ionization yield of recoiling nuclei in liquid argon as a function of applied electric field by exposing a dual-phase liquid argon time projection chamber (LAr-TPC) to a low energy pulsed narrow band neutron beam produced at the Notre Dame Institute for Structure and Nuclear Astrophysics. Liquid scintillation counters were arranged to detect and identify neutrons scattered in the TPC and to select the energy of the recoiling nuclei. We also report measurements of the scintillation yields for nuclear recoils with energies from 10.3 to 57.3 keV and for median applied electric fields from 0 to 970 V/cm. For the ionization yields, we report measurements from 16.9 to 57.3 keV and for electric fields from 96.4 to 486 V/cm. Furthermore, we report the observation of an anticorrelation between scintillation and ionization from nuclear recoils, which is similar to the anticorrelation between scintillation and ionization from electron recoils. Assuming that the energy loss partitions into excitons and ion pairs from 83mKr internal conversion electrons is comparable to that from 207Bi conversion electrons, we obtained the numbers of excitons (Nex) and ion pairs (Ni) and their ratio (Nex/Ni) produced by nuclear recoils from 16.9 to 57.3 keV. Motivated by arguments suggesting direction sensitivity in LAr-TPC signals due to columnar recombination, a comparison of the light and charge yield of recoils parallel and perpendicular to the applied electric field is presented for the first time.

  4. Measurement of Scintillation and Ionization Yield and Scintillation Pulse Shape from Nuclear Recoils in Liquid Argon

    DOE PAGESBeta

    Cao, H.

    2015-05-26

    We have measured the scintillation and ionization yield of recoiling nuclei in liquid argon as a function of applied electric field by exposing a dual-phase liquid argon time projection chamber (LAr-TPC) to a low energy pulsed narrow band neutron beam produced at the Notre Dame Institute for Structure and Nuclear Astrophysics. Liquid scintillation counters were arranged to detect and identify neutrons scattered in the TPC and to select the energy of the recoiling nuclei. We also report measurements of the scintillation yields for nuclear recoils with energies from 10.3 to 57.3 keV and for median applied electric fields from 0more » to 970 V/cm. For the ionization yields, we report measurements from 16.9 to 57.3 keV and for electric fields from 96.4 to 486 V/cm. Furthermore, we report the observation of an anticorrelation between scintillation and ionization from nuclear recoils, which is similar to the anticorrelation between scintillation and ionization from electron recoils. Assuming that the energy loss partitions into excitons and ion pairs from 83mKr internal conversion electrons is comparable to that from 207Bi conversion electrons, we obtained the numbers of excitons (Nex) and ion pairs (Ni) and their ratio (Nex/Ni) produced by nuclear recoils from 16.9 to 57.3 keV. Motivated by arguments suggesting direction sensitivity in LAr-TPC signals due to columnar recombination, a comparison of the light and charge yield of recoils parallel and perpendicular to the applied electric field is presented for the first time.« less

  5. Application of refractive scintillation theory to radio transmission through the ionosphere and the solar wind, and to reflection from a rough ocean

    NASA Astrophysics Data System (ADS)

    Booker, H. G.

    1981-11-01

    The theory of diffractive scattering by small-scale irregularities is combined with the results of Booker and MajidiAhi (1981) concerning refractive scattering by large-scale irregularities in a phase-changing screen, in a study of three intensity scintillation phenomena: (1) the reflection of radio and optical waves from an ocean surface disturbed by a spectrum of water waves; (2) the scintillation of VHF, UHF and SHF radio waves traversing the ionospheric F-region; and (3) the scintillation of the radio waves mentioned while traversing the solar wind. Spectral diagrams are drawn to show how the outer, inner, Fresnel, focal, lens and peak scales vary with such relevant parameters as electromagnetic wave-frequency for the ocean, RMS fractional fluctuation of ionization density for the ionosphere, and distance of closest approach to the sun for the solar wind.

  6. Screening for cancer

    SciTech Connect

    Miller, A.B.

    1985-01-01

    This book contains three sections: Fundamentals of Screening, Screening Tests, and Screening for Specific Cancer Sites. Each section consists of several chapters. Some of the chapter titles are: Principles of Screening and of the Evaluation of Screening Programs; Economic Aspects of Screening; Cervical Cytology; Screening Tests for Bladder Cancer; Fecal Occult Blood Testing; Screening for Cancer of the Cervix; Screening for Gastric Cancer; and Screening for Oral Cancer.

  7. Purification of KamLAND-Zen liquid scintillator

    NASA Astrophysics Data System (ADS)

    Ikeda, Haruo

    2013-08-01

    KamLAND-Zen is neutrino-less double-beta decay search experiment using enriched 300 kg of 136Xe dissolved in pure liquid scintillator. This report is purification work of liquid scintillator for KamLAND-Zen experiment before installation in the inner-balloon and background rejection processes after installation.

  8. A study of GPS ionospheric scintillations observed at Guilin

    NASA Astrophysics Data System (ADS)

    Zou, Yuhua; Wang, Dongli

    2009-12-01

    The occurrence of strong ionospheric scintillations with S4>=0.2 was studied using global positioning system (GPS) measurements at Guilin (25.29°N, 110.33°E; geomagnetic: 15.04°N, 181.98°E), a station located near the northern crest of equatorial anomaly in China. The results are presented for data collected from January 2007 to December 2008. The results show that amplitude scintillations occurred only during the first five months of the considered years. Nighttime amplitude scintillations, observed mainly in the south of Guilin, always occurred with phase scintillations, total electron content (TEC) depletions, and Rate Of change of TEC (ROT) fluctuations. However, TEC depletions and ROT fluctuations were weak during daytime amplitude scintillations, and daytime amplitude scintillations usually occurred in most of the azimuth directions. GPS scintillation/TEC observations recorded at Guilin and signal-to-noise-ratio measurements obtained from GPS-COSMIC radio occultation indicate that nighttime and daytime scintillations are very likely caused by ionospheric F region irregularities and sporadic E, respectively.

  9. Performance comparison of scintillators for alpha particle detectors

    NASA Astrophysics Data System (ADS)

    Morishita, Yuki; Yamamoto, Seiichi; Izaki, Kenji; Kaneko, Junichi H.; Toui, Kohei; Tsubota, Youichi; Higuchi, Mikio

    2014-11-01

    Scintillation detectors for alpha particles are often used in nuclear fuel facilities. Alpha particle detectors have also become important in the research field of radionuclide therapy using alpha emitters. ZnS(Ag) is the most often used scintillator for alpha particle detectors because its light output is high. However, the energy resolution of ZnS(Ag)-based scintillation detectors is poor because they are not transparent. A new ceramic sample, namely the cerium doped Gd2Si2O7 (GPS) scintillator, has been tested as alpha particle detector and its performances have been compared to that one of three different scintillating materials: ZnS(Ag), GAGG and a standard plastic scintillator. The different scintillating materials have been coupled to two different photodetectors, namely a photomultiplier tube (PMT) and a Silicon Photo-multiplier (Si-PM): the performances of each detection system have been compared. Promising results as far as the energy resolution performances (10% with PMT and 14% with Si-PM) have been obtained in the case of GPS and GAGG samples. Considering the quantum efficiencies of the photodetectors under test and their relation to the emission wavelength of the different scintillators, the best results were achieved coupling the GPS with the PMT and the GAGG with the Si-PM

  10. Purification of KamLAND-Zen liquid scintillator

    SciTech Connect

    Ikeda, Haruo

    2013-08-08

    KamLAND-Zen is neutrino-less double-beta decay search experiment using enriched 300 kg of {sup 136}Xe dissolved in pure liquid scintillator. This report is purification work of liquid scintillator for KamLAND-Zen experiment before installation in the inner-balloon and background rejection processes after installation.

  11. Microprocessor-based single particle calibration of scintillation counter

    NASA Technical Reports Server (NTRS)

    Mazumdar, G. K. D.; Pathak, K. M.

    1985-01-01

    A microprocessor-base set-up is fabricated and tested for the single particle calibration of the plastic scintillator. The single particle response of the scintillator is digitized by an A/D converter, and a 8085 A based microprocessor stores the pulse heights. The digitized information is printed. Facilities for CRT display and cassette storing and recalling are also made available.

  12. Characterizing Properties and Performance of 3D Printed Plastic Scintillators

    NASA Astrophysics Data System (ADS)

    McCormick, Jacob

    2015-10-01

    We are determining various characteristics of the performance of 3D printed scintillators. A scintillator luminesces when an energetic particle raises electrons to an excited state by depositing some of its energy in the atom. When these excited electrons fall back down to their stable states, they emit the excess energy as light. We have characterized the transmission spectrum, emission spectrum, and relative intensity of light produced by 3D printed scintillators. We are also determining mechanical properties such as tensile strength and compressibility, and the refractive index. The emission and transmission spectra were measured using a monochromator. By observing the transmission spectrum, we can see which optical wavelengths are absorbed by the scintillator. This is then used to correct the emission spectrum, since this absorption is present in the emission spectrum. Using photomultiplier tubes in conjunction with integration hardware (QDC) to measure the intensity of light emitted by 3D printed scintillators, we compare with commercial plastic scintillators. We are using the characterizations to determine if 3D printed scintillators are a viable alternative to commercial scintillators for use at Jefferson Lab in nuclear and accelerated physics detectors. I would like to thank Wouter Deconinck, as well as the Parity group at the College of William and Mary for all advice and assistance with my research.

  13. Measurement of ortho-positronium properties in liquid scintillators

    NASA Astrophysics Data System (ADS)

    Perasso, S.; Consolati, G.; Franco, D.; Hans, S.; Jollet, C.; Meregaglia, A.; Tonazzo, A.; Yeh, M.

    2013-08-01

    Pulse shape discrimination in liquid scintillator detectors is a well-established technique for the discrimination of heavy particles from light particles. Nonetheless, it is not efficient in the separation of electrons and positrons, as they give rise to indistinguishable scintillator responses. This inefficiency can be overtaken through the exploitation of the formation of ortho-Positronium (o-Ps), which alters the time profile of light pulses induced by positrons. We characterized the o-Ps properties in the most commonly used liquid scintillators, i.e. PC, PXE, LAB, OIL and PC + PPO. In addition, we studied the effects of scintillator doping on the o-Ps properties for dopants currently used in neutrino experiments, Gd and Nd. Further measurements for Li-loaded and Tl-loaded liquid scintillators are foreseen. We found that the o-Ps properties are suitable for enhancing the electron-positron discrimination.

  14. Measurement of ortho-positronium properties in liquid scintillators

    SciTech Connect

    Perasso, S.; Franco, D.; Tonazzo, A.; Consolati, G.; Hans, S.; Yeh, M.; Jollet, C.; Meregaglia, A.

    2013-08-08

    Pulse shape discrimination in liquid scintillator detectors is a well-established technique for the discrimination of heavy particles from light particles. Nonetheless, it is not efficient in the separation of electrons and positrons, as they give rise to indistinguishable scintillator responses. This inefficiency can be overtaken through the exploitation of the formation of ortho-Positronium (o-Ps), which alters the time profile of light pulses induced by positrons. We characterized the o-Ps properties in the most commonly used liquid scintillators, i.e. PC, PXE, LAB, OIL and PC + PPO. In addition, we studied the effects of scintillator doping on the o-Ps properties for dopants currently used in neutrino experiments, Gd and Nd. Further measurements for Li-loaded and Tl-loaded liquid scintillators are foreseen. We found that the o-Ps properties are suitable for enhancing the electron-positron discrimination.

  15. Hearing Screening

    ERIC Educational Resources Information Center

    Johnson-Curiskis, Nanette

    2012-01-01

    Hearing levels are threatened by modern life--headsets for music, rock concerts, traffic noises, etc. It is crucial we know our hearing levels so that we can draw attention to potential problems. This exercise requires that students receive a hearing screening for their benefit as well as for making the connection of hearing to listening.

  16. Classroom Screening.

    ERIC Educational Resources Information Center

    Alpha Plus Corp., Piedmont, CA.

    This classroom screening device was developed by the Circle Preschool First Chance Project, a government-funded program to integrate handicapped children into regular classroom activities, for use in preschools, nursery schools, Head Start centers and other agencies working with young children. It is designed to give a gross measure of a child's…

  17. SDC conceptual design: Scintillating fiber outer tracker

    SciTech Connect

    Adams, D.; Baumbaugh, A.; Bird, F.; SDC Collaboration

    1992-01-22

    The authors propose an all-scintillating fiber detector for the purpose of outer tracking for the SDC. The objectives of this tracking system are to: (1) provide a first level trigger for {vert_bar}{eta}{vert_bar} < 2.3 with sharp p{sub T} threshold with the ability to resolve individual beam crossings; (2) provide pattern recognition capability and momentum resolution which complements and extends the capabilities of the inner silicon tracking system; (3) provide three dimensional linkage with outer detection systems including the shower maximum detector, muon detectors, and calorimetry; (4) provide robust tracking and track-triggering at the highest luminosities expected at the SSC. The many attractive features of a fiber tracker include good position resolution, low occupancy, low mass in the active volume, and excellent resistance to radiation damage. An additional important feature, especially at the SSC, is the intrinsically prompt response time of a scintillating fiber. This property is exploited in the construction of a level 1 trigger sensitive to individual beam crossings.

  18. Scintillating bolometers for the LUCIFER project

    NASA Astrophysics Data System (ADS)

    Pattavina, L.; LUCIFER Collaboration

    2016-05-01

    Neutrinoless double beta decay (0vββ) is one of the most sensitive probes for physics beyond the Standard Model, providing unique information on the nature and masses of neutrinos. In order to explore the so-called inverted neutrino mass hierarchy region a further improvement on the upcoming 0vββ experiment is needed. In this respect, scintillating bolometers are the suitable technology for achieving such goal: they ensure excellent energy resolution and highly efficient particle discrimination. The LUCIFER project aims at deploying the first array of enriched scintillating bolometers for the investigation of 0vββ of 82Se. The matrix which embeds the source is an array of Zn 82Se crystals, where enriched 82Se is used as decay isotope. Taking advantage of the large Q-value (2997 keV) and of the particle discrimination, the expected background rate in the region of interest is as low as 10-3 c/keV/kg/y. The foreseen sensitivity after 2 years of live time will be 1.8×1025 years. We will report on the potential of such technology and on the present status of the project.

  19. Characterization of cerium fluoride nanocomposite scintillators

    SciTech Connect

    Stange, Sy; Esch, Ernst I; Brown, Leif O; Couture, Aaron J; Mckigney, Edward A; Muenchausen, Ross E; Del Sesto, Rico E; Gilbertson, Robert D; Mccleskey, T Mark; Reifarth, Rene

    2009-01-01

    Measurement of the neutron capture cross-sections of a number of short-lived isotopes would advance both pure and applied scientific research. These cross-sections are needed for calculation of criticality and waste production estimates for the Advanced Fuel Cycle Initiative, for analysis of data from nuclear weapons tests, and to improve understanding of nucleosynthesis. However, measurement of these cross-sections would require a detector with a faster signal decay time than those used in existing neutron capture experiments. Crystals of faster detector materials are not available in sufficient sizes and quantities to supply these large-scale experiments. Instead, we propose to use nanocomposite detectors, consisting of nanoscale particles of a scintillating material dispersed in a matrix material. We have successfully fabricated cerium fluoride (CeF{sub 3}) nanoparticles and dispersed them in a liquid matrix. We have characterized this scintillator and have measured its response to neutron capture. Results of the optical, structural, and radiation characterization will be presented.

  20. A scintillating fiber dosimeter for radiotherapy

    NASA Astrophysics Data System (ADS)

    Bartesaghi, G.; Conti, V.; Bolognini, D.; Grigioni, S.; Mascagna, V.; Prest, M.; Scazzi, S.; Mozzanica, A.; Cappelletti, P.; Frigerio, M.; Gelosa, S.; Monti, A.; Ostinelli, A.; Giannini, G.; Vallazza, E.

    2007-10-01

    Radiotherapy, together with chemotherapy and surgery, is one of the main methods applied in the fight against cancer; in order to increase the chances of a successful radiotherapy treatment the dose delivery to the tumor and the surrounding normal tissues has to be computed with high accuracy. Traditional dosimeters are accurate but single channel (ionization chambers and diodes) or non real-time (radiographic films) devices. At present there is no device water equivalent that can perform real-time and bidimensional measurements of a dose distribution. This article describes the development of a real-time dosimeter based on scintillating fibers for photon and electron beams; the fibers are made of polystyrene, that is water equivalent and thus tissue equivalent, allowing a direct dose calculation. Three prototypes (single and multichannel) have been assembled, consisting in small scintillators coupled to white fibers that carry the light to photomultiplier tubes. In this article the prototypes and the readout electronics are described, together with the results of the measurements with electron and photon beams with energy up to 20 MeV (produced by linear accelerators Varian Clinac 1800 and 2100CD).

  1. Measuring scintillation light using Visible Light

    NASA Astrophysics Data System (ADS)

    Chavarria, Alvaro

    2006-11-01

    A new search for the neutron electric dipole moment (EDM) using ultra cold neutrons proposes an improvement on the neutron EDM by two orders of magnitude over the current limit (to 10-28 e*cm). Detection of scintillation light in superfluid ^4He is at the heart of this experiment. One possible scheme to detect this light is to use wavelength-shifting fibers in the superfluid ^4He to collect the scintillation light and transport it out of the measuring cell. The fiber terminates in a visible light photon counter (VLPC). VLPCs are doped, silicon based, solid state photomultipliers with high quantum efficiency (up to 80%) and high gain ( 40000 electrons per converted photon). Moreover, they are insensitive to magnetic fields and operate at temperatures of 6.5K. A test setup has been assembled at Duke University using acrylic cells wrapped in wavelength-shifting fibers that terminate on VLPCs. This setup is being used to evaluate the feasibility of this light detection scheme. The results obtained in multiple experiments done over the past summer (2006) and the current status of the project will be presented at the conference.Reference:A New Search for the Neutron Electric Dipole Moment, funding pre-proposal by the EDM collaboration; R. Golub and S. Lamoreaux, Phys. Rep. 237, 1 (1994).

  2. Liquid Scintillation Detectors for High Energy Neutrinos

    SciTech Connect

    Smith, Stefanie N.; Learned, John G.

    2010-03-30

    Large open volume (not segmented) liquid scintillation detectors have been generally dedicated to low energy neutrino measurements, in the MeV energy region. We describe the potential employment of large detectors (>1 kiloton) for studies of higher energy neutrino interactions, such as cosmic rays and long-baseline experiments. When considering the physics potential of new large instruments the possibility of doing useful measurements with higher energy neutrino interactions has been overlooked. Here we take into account Fermat's principle, which states that the first light to reach each PMT will follow the shortest path between that PMT and the point of origin. We describe the geometry of this process, and the resulting wavefront, which we are calling the 'Fermat surface', and discuss methods of using this surface to extract directional track information and particle identification. This capability may be demonstrated in the new long-baseline neutrino beam from Jaeri accelerator to the KamLAND detector in Japan. Other exciting applications include the use of Hanohano as a movable long-baseline detector in this same beam, and LENA in Europe for future long-baseline neutrino beams from CERN. Also, this methodology opens up the question as to whether a large liquid scintillator detector should be given consideration for use in a future long-baseline experiment from Fermilab to the DUSEL underground laboratory at Homestake.

  3. Imaging of gamma emitters using scintillation cameras

    NASA Astrophysics Data System (ADS)

    Ricard, Marcel

    2004-07-01

    Since their introduction by Hal Anger in the late 1950s, the gamma cameras have been widely used in the field of nuclear medicine. The original concept is based on the association of a large field of view scintillator optically coupled with an array of photomultiplier tubes (PMTs), in order to locate the position of interactions inside the crystal. Using a dedicated accessory, like a parallel hole collimator, to focus the field of view toward a predefined direction, it is possible to built up an image of the radioactive distribution. In terms of imaging performances, three main characteristics are commonly considered: uniformity, spatial resolution and energy resolution. Major improvements were mainly due to progress in terms of industrial process regarding analogical electronic, crystal growing or PMTs manufacturing. Today's gamma camera is highly digital, from the PMTs to the display. All the corrections are applied "on the fly" using up to date signal processing techniques. At the same time some significant progresses have been achieved in the field of collimators. Finally, two new technologies have been implemented, solid detectors like CdTe or CdZnTe, and pixellized scintillators plus photodiodes or position sensitive photomultiplier tubes. These solutions are particularly well adapted to build dedicated gamma camera for breast or intraoperative imaging.

  4. Kinetic Monte Carlo simulations of scintillation processes in NaI(Tl)

    SciTech Connect

    Kerisit, Sebastien N.; Wang, Zhiguo; Williams, Richard; Grim, Joel; Gao, Fei

    2014-04-26

    Developing a comprehensive understanding of the processes that govern the scintillation behavior of inorganic scintillators provides a pathway to optimize current scintillators and allows for the science-driven search for new scintillator materials. Recent experimental data on the excitation density dependence of the light yield of inorganic scintillators presents an opportunity to incorporate parameterized interactions between excitations in scintillation models and thus enable more realistic simulations of the nonproportionality of inorganic scintillators. Therefore, a kinetic Monte Carlo (KMC) model of elementary scintillation processes in NaI(Tl) is developed in this work to simulate the kinetics of scintillation for a range of temperatures and Tl concentrations as well as the scintillation efficiency as a function of excitation density. The ability of the KMC model to reproduce available experimental data allows for elucidating the elementary processes that give rise to the kinetics and efficiency of scintillation observed experimentally for a range of conditions.

  5. Unexpected behaviour of polystyrene-based scintillating fibers during irradiation at low doses and low dose rates

    NASA Astrophysics Data System (ADS)

    Wick, K.; Zoufal, T.

    2001-12-01

    The time dependence of the optical radiation damage process was studied for different fibers with polystyrene (PS) core. The fibers were irradiated with X-rays. In the present experiment the light guide BCF-98 (Bicron, clear polystyrene) was compared with the two scintillating fibers SCSF-38 and SCSF-81 (Kuraray). The light transmission through the fiber was investigated before, during and after irradiation. All investigated fibers showed unexpected effects depending on the fiber type: (1) at low doses the scintillating fibers are more sensitive to radiation than at high doses, i.e. the optical absorption rises nonlinearly with dose; (2) shortlived optical absorption centers decaying within several hours were detected in all fibers with PS core investigated up to now. Especially for SCSF-81, the annealing part is large and it totally overlaps the emission spectrum of the fiber.

  6. Synthesis and characterization of a BaGdF5:Tb glass ceramic as a nanocomposite scintillator for x-ray imaging.

    PubMed

    Lee, Gyuhyon; Struebing, Christian; Wagner, Brent; Summers, Christopher; Ding, Yong; Bryant, Alex; Thadhani, Naresh; Shedlock, Daniel; Star-Lack, Josh; Kang, Zhitao

    2016-05-20

    Transparent glass ceramics with embedded light-emitting nanocrystals show great potential as low-cost nanocomposite scintillators in comparison to single crystal and transparent ceramic scintillators. In this study, cubic structure BaGdF5:Tb nanocrystals embedded in an aluminosilicate glass matrix are reported for potential high performance MeV imaging applications. Scintillator samples with systematically varied compositions were prepared by a simple conventional melt-quenching method followed by annealing. Optical, structural and scintillation properties were characterized to guide the design and optimization of selected material systems, aiming at the development of a system with higher crystal volume and larger crystal size for improved luminosity. It is observed that enhanced scintillation performance was achieved by tuning the glass matrix composition and using GdF3 in the raw materials, which served as a nucleation agent. A 26% improvement in light output was observed from a BaGdF5:Tb glass ceramic with addition of GdF3. PMID:27044066

  7. Synthesis and characterization of a BaGdF5:Tb glass ceramic as a nanocomposite scintillator for x-ray imaging

    NASA Astrophysics Data System (ADS)

    Lee, Gyuhyon; Struebing, Christian; Wagner, Brent; Summers, Christopher; Ding, Yong; Bryant, Alex; Thadhani, Naresh; Shedlock, Daniel; Star-Lack, Josh; Kang, Zhitao

    2016-05-01

    Transparent glass ceramics with embedded light-emitting nanocrystals show great potential as low-cost nanocomposite scintillators in comparison to single crystal and transparent ceramic scintillators. In this study, cubic structure BaGdF5:Tb nanocrystals embedded in an aluminosilicate glass matrix are reported for potential high performance MeV imaging applications. Scintillator samples with systematically varied compositions were prepared by a simple conventional melt-quenching method followed by annealing. Optical, structural and scintillation properties were characterized to guide the design and optimization of selected material systems, aiming at the development of a system with higher crystal volume and larger crystal size for improved luminosity. It is observed that enhanced scintillation performance was achieved by tuning the glass matrix composition and using GdF3 in the raw materials, which served as a nucleation agent. A 26% improvement in light output was observed from a BaGdF5:Tb glass ceramic with addition of GdF3.

  8. Colostomy Guide

    MedlinePlus

    ... window. My Saved Articles » My ACS » Colostomy: A Guide Download Printable Version [PDF] » ( En español ) Colostomy surgery ... the activities you enjoyed in the past. This guide will help you better understand colostomy – what it ...

  9. Optimization of the Performance of Segmented Scintillators for Radiotherapy Imaging through Novel Binning Techniques

    PubMed Central

    El-Mohri, Youcef; Antonuk, Larry E.; Choroszucha, Richard B.; Zhao, Qihua; Jiang, Hao; Liu, Langechuan

    2014-01-01

    Thick, segmented crystalline scintillators have shown increasing promise as replacement x-ray converters for the phosphor screens currently used in active matrix flat-panel imagers (AMFPIs) in radiotherapy, by virtue of providing over an order of magnitude improvement in the DQE. However, element-to-element misalignment in current segmented scintillator prototypes creates a challenge for optimal registration with underlying AMFPI arrays, resulting in degradation of spatial resolution. To overcome this challenge, a methodology involving the use of a relatively high resolution AMFPI array in combination with novel binning techniques is presented. The array, which has a pixel pitch of 0.127 mm, was coupled to prototype segmented scintillators based on BGO, LYSO and CsI:Tl materials, each having a nominal element-to-element pitch of 1.016 mm and thickness of ~1 cm. The AMFPI systems incorporating these prototypes were characterized at a radiotherapy energy of 6 MV in terms of MTF, NPS, DQE, and reconstructed images of a resolution phantom acquired using a cone-beam CT geometry. For each prototype, the application of 8×8 pixel binning to achieve a sampling pitch of 1.016 mm was optimized through use of an alignment metric which minimized misregistration and thereby improved spatial resolution. In addition, the application of alternative binning techniques that exclude the collection of signal near septal walls resulted in further significant improvement in spatial resolution for the BGO and LYSO prototypes, though not for the CsI:Tl prototype due to the large amount of optical cross-talk resulting from significant light spread between scintillator elements in that device. The efficacy of these techniques for improving spatial resolution appears to be enhanced for scintillator materials that exhibit mechanical hardness, high density and high refractive index, such as BGO. Moreover, materials that exhibit these properties as well as offer significantly higher light

  10. Optimization of the performance of segmented scintillators for radiotherapy imaging through novel binning techniques

    NASA Astrophysics Data System (ADS)

    El-Mohri, Youcef; Antonuk, Larry E.; Choroszucha, Richard B.; Zhao, Qihua; Jiang, Hao; Liu, Langechuan

    2014-02-01

    Thick, segmented crystalline scintillators have shown increasing promise as replacement x-ray converters for the phosphor screens currently used in active matrix flat-panel imagers (AMFPIs) in radiotherapy, by virtue of providing over an order of magnitude improvement in the detective quantum efficiency (DQE). However, element-to-element misalignment in current segmented scintillator prototypes creates a challenge for optimal registration with underlying AMFPI arrays, resulting in degradation of spatial resolution. To overcome this challenge, a methodology involving the use of a relatively high resolution AMFPI array in combination with novel binning techniques is presented. The array, which has a pixel pitch of 0.127 mm, was coupled to prototype segmented scintillators based on BGO, LYSO and CsI:Tl materials, each having a nominal element-to-element pitch of 1.016 mm and thickness of ∼1 cm. The AMFPI systems incorporating these prototypes were characterized at a radiotherapy energy of 6 MV in terms of modulation transfer function, noise power spectrum, DQE, and reconstructed images of a resolution phantom acquired using a cone-beam CT geometry. For each prototype, the application of 8 × 8 pixel binning to achieve a sampling pitch of 1.016 mm was optimized through use of an alignment metric which minimized misregistration and thereby improved spatial resolution. In addition, the application of alternative binning techniques that exclude the collection of signal near septal walls resulted in further significant improvement in spatial resolution for the BGO and LYSO prototypes, though not for the CsI:Tl prototype due to the large amount of optical cross-talk resulting from significant light spread between scintillator elements in that device. The efficacy of these techniques for improving spatial resolution appears to be enhanced for scintillator materials that exhibit mechanical hardness, high density and high refractive index, such as BGO. Moreover, materials

  11. Optimization of the performance of segmented scintillators for radiotherapy imaging through novel binning techniques.

    PubMed

    El-Mohri, Youcef; Antonuk, Larry E; Choroszucha, Richard B; Zhao, Qihua; Jiang, Hao; Liu, Langechuan

    2014-02-21

    Thick, segmented crystalline scintillators have shown increasing promise as replacement x-ray converters for the phosphor screens currently used in active matrix flat-panel imagers (AMFPIs) in radiotherapy, by virtue of providing over an order of magnitude improvement in the detective quantum efficiency (DQE). However, element-to-element misalignment in current segmented scintillator prototypes creates a challenge for optimal registration with underlying AMFPI arrays, resulting in degradation of spatial resolution. To overcome this challenge, a methodology involving the use of a relatively high resolution AMFPI array in combination with novel binning techniques is presented. The array, which has a pixel pitch of 0.127 mm, was coupled to prototype segmented scintillators based on BGO, LYSO and CsI:Tl materials, each having a nominal element-to-element pitch of 1.016 mm and thickness of ∼ 1 cm. The AMFPI systems incorporating these prototypes were characterized at a radiotherapy energy of 6 MV in terms of modulation transfer function, noise power spectrum, DQE, and reconstructed images of a resolution phantom acquired using a cone-beam CT geometry. For each prototype, the application of 8 × 8 pixel binning to achieve a sampling pitch of 1.016 mm was optimized through use of an alignment metric which minimized misregistration and thereby improved spatial resolution. In addition, the application of alternative binning techniques that exclude the collection of signal near septal walls resulted in further significant improvement in spatial resolution for the BGO and LYSO prototypes, though not for the CsI:Tl prototype due to the large amount of optical cross-talk resulting from significant light spread between scintillator elements in that device. The efficacy of these techniques for improving spatial resolution appears to be enhanced for scintillator materials that exhibit mechanical hardness, high density and high refractive index, such as BGO. Moreover, materials

  12. Investigation of the effect of the scintillator material on the overall X-ray detection system performance by application of analytical models

    NASA Astrophysics Data System (ADS)

    Efthimiou, N.; Kalivas, N.; Patatoukas, G.; Konstantinidis, A.; Valais, I.; Nikolopoulos, D.; Gaitanis, A.; David, S.; Michail, C.; Loudos, G.; Cavouras, D.; Panayiotakis, G.; Kandarakis, I.

    2007-02-01

    The purpose of the present work was to model a modern X-ray detection system and to investigate the effect of the scintillator material on the detector's output signal. The scintillators were used in the form of screens. The parameters investigated were the Modulation Transfer Function (MTF), the Detective Quantum Efficiency (DQE) and the Energy Absorption Efficiency (EAE). The results for some well-known scintillators (Y 3Al 5O 12:Ce, Y 2O 3:Eu, ZnSCdS:Ag, Lu 3Al 5O 7, CdWO 4) are presented. Typical radiographic conditions were considered as input parameters. For simulation purposes, the intrinsic conversion efficiency ( ηc), the total number of optical photons produced per incident X-ray ( m0), the attenuation coefficients and other optical parameters of the scintillator materials, were taken as input data. The complete simulation procedure was performed in a specially designed Graphical User Interface (GUI). The results showed that the Y 2O 3:Eu scintillator presented similar behavior to that of ZnSCdS:Ag, exhibiting higher DQE at zero spatial frequencies. For higher frequencies, however, the DQE values of Lu 3Al 5O 7 and CdWO 4 prevailed.

  13. Monte Carlo calculation of the spatial response (Modulated Transfer Function) of a scintillation flat panel and comparison with experimental results

    NASA Astrophysics Data System (ADS)

    Juste, Belén; Miró, Rafael; Monasor, Paula; Verdú, Gumersindo

    2015-11-01

    Phosphor screens are commonly used in many X-ray imaging applications. The design and optimization of these detectors can be achieved using Monte Carlo codes to simulate radiation transport in scintillation materials and to improve the spatial response. This work presents an exhaustive procedure to measure the spatial resolution of a scintillation flat panel image and to evaluate the agreement with data obtained by simulation. To evaluate the spatial response we have used the Modulated Transfer Function (MTF) parameter. According to this, we have obtained the Line Spread Function (LSF) of the system since the Fourier Transform (FT) of the LSF gives the MTF. The experimental images were carried out using a medical X-ray tube (Toshiba E7299X) and a flat panel (Hammamatsu C9312SK). Measurements were based on the slit methodology experimental implementation, which measures the response of the system to a line. LSF measurements have been performed using a 0.2 mm wide lead slit superimposed over the flat panel. The detector screen was modelled with MCNP (version 6) Monte Carlo simulation code in order to analyze the effect of the acquisition setup configuration and to compare the response of scintillator screens with the experimental results. MCNP6 offers the possibility of studying the optical physics parameters (optical scattering and absorption coefficients) that occur in the phosphor screen. The study has been tested for different X-ray tube voltages, from 100 to 140 kV. An acceptable convergence between the MTF results obtained with MCNP6 and the experimental measurements have been obtained.

  14. RADTRAN 5 user guide.

    SciTech Connect

    Kanipe, Frances L.; Neuhauser, Karen Sieglinde

    2003-07-01

    This User Guide for the RADTRAN 5 computer code for transportation risk analysis describes basic risk concepts and provides the user with step-by-step directions for creating input files by means of either the RADDOG input file generator software or a text editor. It also contains information on how to interpret RADTRAN 5 output, how to obtain and use several types of important input data, and how to select appropriate analysis methods. Appendices include a glossary of terms, a listing of error messages, data-plotting information, images of RADDOG screens, and a table of all data in the internal radionuclide library.

  15. Comparison of Luminescence ADP Production Assay and Radiometric Scintillation Proximity Assay for Cdc7 Kinase

    PubMed Central

    Takagi, Toshimitsu; Shum, David; Parisi, Monika; Santos, Ruth E.; Radu, Constantin; Calder, Paul; Rizvi, Zahra; Frattini, Mark G.; Djaballah, Hakim

    2013-01-01

    Several assay technologies have been successfully adapted and used in HTS to screen for protein kinase inhibitors; however, emerging comparative analysis studies report very low hit overlap between the different technologies, which challenges the working assumption that hit identification is not dependent on the assay method of choice. To help address this issue, we performed two screens on the cancer target, Cdc7-Dbf4 heterodimeric protein kinase, using a direct assay detection method measuring [33P]-phosphate incorporation into the substrate and an indirect method measuring residual ADP production using luminescence. We conducted the two screens under similar conditions, where in one, we measured [33P]-phosphate incorporation using scintillation proximity assay (SPA), and in the other, we detected luminescence signal of the ATP-dependent luciferase after regenerating ATP from residual ADP (LUM). Surprisingly, little or no correlation were observed between the positives identified by the two methods; at a threshold of 30% inhibition, 25 positives were identified in the LUM screen whereas the SPA screen only identified two positives, Tannic acid and Gentian violet, with Tannic acid being common to both. We tested 20 out of the 25 positive compounds in secondary confirmatory study and confirmed 12 compounds including Tannic acid as Cdc7-Dbf4 kinase inhibitors. Gentian violet, which was only positive in the SPA screen, inhibited luminescence detection and categorized as a false positive. This report demonstrates the strong impact in detection format on the success of a screening campaign and the importance of carefully designed confirmatory assays to eliminate those compounds that target the detection part of the assay. PMID:21564015

  16. Vision Screening

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Visi Screen OSS-C, marketed by Vision Research Corporation, incorporates image processing technology originally developed by Marshall Space Flight Center. Its advantage in eye screening is speed. Because it requires no response from a subject, it can be used to detect eye problems in very young children. An electronic flash from a 35 millimeter camera sends light into a child's eyes, which is reflected back to the camera lens. The photorefractor then analyzes the retinal reflexes generated and produces an image of the child's eyes, which enables a trained observer to identify any defects. The device is used by pediatricians, day care centers and civic organizations that concentrate on children with special needs.

  17. Development of scintillation materials for medical imaging and other applications

    SciTech Connect

    Melcher, C. L.

    2013-02-05

    Scintillation materials that produce pulses of visible light in response to the absorption of energetic photons, neutrons, and charged particles, are widely used in various applications that require the detection of radiation. The discovery and development of new scintillators has accelerated in recent years, due in large part to their importance in medical imaging as well as in security and high energy physics applications. Better understanding of fundamental scintillation mechanisms as well as the roles played by defects and impurities have aided the development of new high performance scintillators for both gamma-ray and neutron detection. Although single crystals continue to dominate gamma-ray based imaging techniques, composite materials and transparent optical ceramics potentially offer advantages in terms of both synthesis processes and scintillation performance. A number of promising scintillator candidates have been identified during the last few years, and several are currently being actively developed for commercial production. Purification and control of raw materials and cost effective crystal growth processes can present significant challenges to the development of practical new scintillation materials.

  18. Implications of Ionospheric Scintillation for GNSS Users in Northern Europe

    NASA Astrophysics Data System (ADS)

    Aquino, Marcio; Moore, Terry; Dodson, Alan; Waugh, Sam; Souter, Jock; Rodrigues, Fabiano S.

    2005-05-01

    Extensive ionospheric scintillation and Total Electron Content (TEC) data were collected by the Institute of Engineering Surveying and Space Geodesy (IESSG) in Northern Europe during years of great impact of the solar maximum on GNSS users (2001 2003). The ionospheric TEC is responsible for range errors due to its time delay effect on transionospheric signals. Electron density irregularities in the ionosphere, occurring frequently during these years, are responsible for (phase and amplitude) fluctuations on GNSS signals, known as ionospheric scintillation. Since June 2001 four GPS Ionospheric Scintillation and TEC Monitor receivers (the NovAtel/AJ Systems GSV4004) have been deployed at stations in the UK and Norway, forming a Northern European network, covering geographic latitudes from 53° to 70° N approximately. These receivers compute and record GPS phase and amplitude scintillation parameters, as well as TEC and TEC variations. The project involved setting up the network and developing automated archiving and data analysis strategies, aiming to study the impact of scintillation on DGPS and EGNOS users, and on different GPS receiver technologies. In order to characterise scintillation and TEC variations over Northern Europe, as well as investigate correlation with geomagnetic activity, long-term statistical analyses were also produced. This paper summarises our findings, providing an overview of the potential implications of ionospheric scintillation for the GNSS user in Northern Europe.

  19. Low/Mid-latitude Ionospheric irregularities and scintillation climatology

    NASA Astrophysics Data System (ADS)

    Abdallah, Amr; Groves, K. M.; Mahrous, Ayman; Hussein, Fayrouz

    Ionospheric scintillation occur when radio signals propagate through an irregular ionosphere (e.g., plasma bubbles). Since plasma bubbles are regions of depleted ion and electron densities, a plasma bubble located on the satellite-to-ground signal path will cause radio signals to fluctuate in phase and amplitude. Ionospheric scintillation data were analyzed in the magnetic latitudinal field-of-view 29° N -13.4° N, observed by a stand-alone SCINDA (Scintillation Network Decision Aid) - GPS receiver at Helwan, Egypt (29.86° N, 31.32° E). A minimum 20° elevation cut off angle has been set in order to minimize the multipath effect. During the enhancing phase of the current solar cycle 24 (years 2010, 2011, 2012 and 2013), the behaviour of the scintillation occurrence were characterized. The seasonal, annual and solar cycle variation of scintillation occurrence is investigated together with the Total Electron Content (TEC), to put in evidence the relation between the electron density gradients and the ionospheric irregularities causing scintillation. This study considers a first step to develop a scintillation climatology over Northern Africa.

  20. Characterization of scintillator materials for fast-ion loss detectors in nuclear fusion reactors

    NASA Astrophysics Data System (ADS)

    Jiménez-Ramos, M. C.; García López, J.; García-Muñoz, M.; Rodríguez-Ramos, M.; Carmona Gázquez, M.; Zurro, B.

    2014-08-01

    . The solid angle subtended by the fiber is ∼2.2 × 10-5 sr. The final element is a compact and high sensitive spectrometer, QE6500 (Ocean Optics Inc.) with a 2D area detector which allow us to measure simultaneously in the range of 200-1100 nm with a spectral resolution ∼1-2 nm. The measured signals were analyzed and stored with the SpectraSuite software [6]. The absolute calibration of the optical system described above was carried out with a HL-2000-CAL Tungsten Halogen Calibration Standard light source which provides absolute intensity values (in μW/cm2/nm) at the fiber port at wavelengths from 360-1050 nm.The beam fluxes used to irradiate the phosphors were ∼ 1012 p/cm2s- for the IL yields determination, and up to ten times higher for the degradation analyses.The Rutherford Backscattering Spectrometry (RBS) measurements of the screens were accomplished in the same vacuum chamber using protons at 3 MeV and 5 MeV. Two different energies were employed due to the large difference between the thicknesses of the samples. The proton beam intensity was 10 nA and the beam size 1 mm of diameter. The analysis were performed with a Passivated Implanted Planar Silicon (PIPS) detector of 300 mm2, positioned at 150° and with a 10 μm thick aluminized mylar foil placed at the detector surface to avoid the light emitted by the scintillators. The RBS spectra were analyzed using the SIMNRA code [7].The scintillators investigated in this work were selected according to their availability, radiation hardness, fast response, and/or prior use in plasma diagnostics. In this paper, three different kinds of materials have been analyzed. The TG-Green (so called by the manufacturer, Sarnoff Corporation, USA) is a Eu doped SrGa2S4 powder substrate with density of 3.65 g/cm3, and presents an emission at 540 nm with a very short decay time.≈490 ns [8]. A TG-Green scintillator coating has been applied, for the first time, to a fusion plasma diagnostics for the detection of fast

  1. Comparison of plastic scintillating fibres and capillaries filled with liquid scintillator

    NASA Astrophysics Data System (ADS)

    Cardini, A.; Cavasinni, V.; Di Girolamo, B.; Flaminio, V.; Golovkin, S. V.; Gorin, A. M.; Kulichenko, A. V.; Kushnirenko, A. E.; Pyshev, A. I.; Manuilov, I.; Vasilchenko, V. G.

    1994-07-01

    A comparison is made between the light yield, attenuation length, time response and light propagation speed in plastic scintillating fibres (SCSF-38 and Kuraray-3HF) and quartz capillaries filled with liquid scintillator (LS) 1-methilnaphthalene (1MN) doped with new dyes R45 and R39. The inner diameter of capillaries and diameter of plastic fibres is 0.5 mm. The number of photoelectrons detected at the far end (2 m) was 2.9 for capillaries filled with 1MN + 3 g/1 R45 while it was 1.8 times smaller in the case of SCSF-38 and 3 times smaller in the case of Kuraray 3HF plastic fibres. Taking into account the quantum efficiency of the photodetector used these reduction factors became 3.0 and 2.0, respectively. Good attenuation length, high light output and also excellent radiation resistance of capillaries filled with LS (> 60 Mrad, measured elsewhere) show that they are a very promising alternative to plastic scintillating fibres for future applications in tracking detectors and calorimeters.

  2. Regional Arctic observations of TEC gradients and scintillations

    NASA Astrophysics Data System (ADS)

    Durgonics, Tibor; Høeg, Per; Benzon, Hans-Henrik

    2015-04-01

    In recent years, there has been growing scientific interest in Arctic ionospheric properties and variations. However our understanding of the fundamental ionospheric processes present in this area is still incomplete. GNSS networks present in Greenland today make it possible to acquire near-real time observations of the state and variations of the high-latitude ionosphere. This data can be employed to obtain relevant geophysical variables and statistics. In our study GPS-derived total electron content (TEC) measurements have been complemented with amplitude scintillation indices (S4), and phase scintillation indices (σφ). The investigation of the relationship between these geophysical variables will likely lead to new ways to study the underlying physical processes and to build tools for monitoring and predicting large-scale patterns in Arctic TEC and scintillations. A number of specific ionosphere events will be presented and the underlying geophysical process will be identified and described. In particular, results will be presented where large-scale gradients in the regional TEC are compared with the growth of scintillations. The statistics of the scintillations will be investigated, with emphasis on how well the scintillations follow the Nakagami-m distribution. The spectra of both the intensities and phase will be calculated, and the corner frequency of these spectra will also be determined. These corner frequencies will be used to compute a number of important geophysical and ionospheric parameters. Furthermore, we will discuss how the spectral characteristics of the scintillations during large TEC gradients vary, and how values of the power spectra slopes change during increasing scintillations. These values will be validated against values found in prior studies. TEC and scintillation time-series and maps will also be presented over the Greenlandic region. We will show how the expansion of the auroral oval during geomagnetic storms can be detected from

  3. Uranium scintillator calorimeter at the CERN ISR

    SciTech Connect

    Gordon, H; Killian, T; Ludlam, T

    1980-01-01

    The design, Monte Carlo studies and test beam results of a uranium/scintillator calorimeter to be installed in the Intersecting Storage Ring (ISR) at CERN are described. In its final stage the calorimeter will cover the full azimuth over a polar region of 45/sup 0/ < theta < 135/sup 0/. The full calorimeter is built in a modular way from 128 stacks, with each stack internally subdivided into six cells of 20 x 20 cm/sup 2/ cross section. The readout is by wavelength shifting (WLS) plates with a separate readout of the front part of the calorimeter (first ten plates) to allow electromagnetic/hadronic separation. Since the readout plates are on both sides of the cells, position information is obtained from the left/right ratio.

  4. Scintillating glass fiber-optic neutron sensors

    NASA Astrophysics Data System (ADS)

    Abel, K. H.; Arthur, R. J.; Bliss, M.

    1994-04-01

    Pacific Northwest Laboratory (PNL) has fabricated cerium-activated lithium silicate scintillating fibers via a hot-downdraw process. These fibers, which, as produced, typically have a transmission length (e(sup -1) length) of greater than 2 meters, are found to undergo aging when subjected to room air. The aging, which is complete in a few weeks, reduces the transmission length to the order of 0.5 meter. Because of the high alkali content of the glass (on the order of 20-30 mole percent lithia), we have attributed this aging to aqueous corrosion at the polymer cladding/glass interface. Changes in transmission with chemical treatment of the surface support the corrosion model. Fiber transmission performance has been preserved by modifying the hot-downdraw to a double crucible to produce glass-on-glass waveguides.

  5. Scintillation fiber hodoscope for topological triggering

    SciTech Connect

    Ferro-Luzzi, M.; Gorin, A.; Korolev, V.; Kuznetsov, A.; Manuilov, I.; Riazantsev, A.; Sidorov, A.; Kobayashi, M.; Yoshimura, Y.; Maki, T.; Kuroda, K.-I.; Penzo, A.; Takeutchi, F.; Okada, K.

    1998-11-09

    A fast and precise scintillating fiber (SciFi) hodoscope based on KURARAY SciFi and HAMAMATSU multianode H6568 tubes was constructed to be used in DIRAC experiment (PS-212) at CERN for tracking and topological triggering information. The front-end electronics was custom developed to allow on-line discrimination after built-in dynamic cross-talk rejection. Preliminary tests of the detector using more than 300 read-out channels have shown an excellent stability and optimum performance for this system: a uniform detection efficiency of 98%, a 125 {mu}m single hit and {approx}0.5 mm two-hit space resolution, 0.6 ns time resolution.

  6. Bulk semiconducting scintillator device for radiation detection

    DOEpatents

    Stowe, Ashley C.; Burger, Arnold; Groza, Michael

    2016-08-30

    A bulk semiconducting scintillator device, including: a Li-containing semiconductor compound of general composition Li-III-VI.sub.2, wherein III is a Group III element and VI is a Group VI element; wherein the Li-containing semiconductor compound is used in one or more of a first mode and a second mode, wherein: in the first mode, the Li-containing semiconductor compound is coupled to an electrical circuit under bias operable for measuring electron-hole pairs in the Li-containing semiconductor compound in the presence of neutrons and the Li-containing semiconductor compound is also coupled to current detection electronics operable for detecting a corresponding current in the Li-containing semiconductor compound; and, in the second mode, the Li-containing semiconductor compound is coupled to a photodetector operable for detecting photons generated in the Li-containing semiconductor compound in the presence of the neutrons.

  7. Scintillation fiber hodoscope for topological triggering

    NASA Astrophysics Data System (ADS)

    Ferro-Luzzi, M.; Gorin, A.; Kobayashi, M.; Korolev, V.; Kuznetsov, A.; Maki, T.; Manuilov, I.; Kuroda, K.-I.; Penzo, A.; Riazantsev, A.; Sidorov, A.; Takeutchi, F.; Okada, K.; Yoshimura, Y.

    1998-11-01

    A fast and precise scintillating fiber (SciFi) hodoscope based on KURARAY SciFi and HAMAMATSU multianode H6568 tubes was constructed to be used in DIRAC experiment (PS-212) at CERN for tracking and topological triggering information. The front-end electronics was custom developed to allow on-line discrimination after built-in dynamic cross-talk rejection. Preliminary tests of the detector using more than 300 read-out channels have shown an excellent stability and optimum performance for this system: a uniform detection efficiency of 98%, a 125 μm single hit and ˜0.5 mm two-hit space resolution, 0.6 ns time resolution.

  8. The Oriented Scintillation Spectrometer Experiment - Instrument description

    NASA Astrophysics Data System (ADS)

    Johnson, W. N.; Kinzer, R. L.; Kurfess, J. D.; Strickman, M. S.; Purcell, W. R.; Grabelsky, D. A.; Ulmer, M. P.; Hillis, D. A.; Jung, G. V.; Cameron, R. A.

    1993-06-01

    The Oriented Scintillation Spectrometer Experiment on the Arthur Holly Compton Gamma Ray Observatory satellite uses four actively shielded NaI (Tl)-CsI(Na) phoswich detectors to provide gamma-ray line and continuum detection capability in the 0.05-10 MeV energy range. The instrument includes secondary capabilities for gamma-ray and neutron detection between 10 and 250 MeV. The detectors have 3.8 deg x 11.04 deg (FWHM) fields of view defined by tungsten collimators. Each detector has an independent, single-axis orientation system which permits offset pointing from the spacecraft Z-axis for background measurements and multitarget observations. The instrument, and its calibration and performance, are described.

  9. The Oriented Scintillation Spectrometer Experiment - Instrument description

    NASA Technical Reports Server (NTRS)

    Johnson, W. N.; Kinzer, R. L.; Kurfess, J. D.; Strickman, M. S.; Purcell, W. R.; Grabelsky, D. A.; Ulmer, M. P.; Hillis, D. A.; Jung, G. V.; Cameron, R. A.

    1993-01-01

    The Oriented Scintillation Spectrometer Experiment on the Arthur Holly Compton Gamma Ray Observatory satellite uses four actively shielded NaI (Tl)-CsI(Na) phoswich detectors to provide gamma-ray line and continuum detection capability in the 0.05-10 MeV energy range. The instrument includes secondary capabilities for gamma-ray and neutron detection between 10 and 250 MeV. The detectors have 3.8 deg x 11.04 deg (FWHM) fields of view defined by tungsten collimators. Each detector has an independent, single-axis orientation system which permits offset pointing from the spacecraft Z-axis for background measurements and multitarget observations. The instrument, and its calibration and performance, are described.

  10. High-Density, Scintillating, Fluoride Glass Calorimeters

    NASA Astrophysics Data System (ADS)

    Akgun, Ugur; Xie, Qiuchen

    2014-03-01

    The unprecedented radiation levels in current Large Hadron Collider runs, and plans to even increase the luminosity creates a need for new detector technologies to be investigated. Here, we propose to use high density, scintillating, fluoride glasses as active media in calorimeters. CHG3 is a special example of this glass family, which has been developed specifically for hadron collider experiments, and is known for fast response time, in addition to high light yield. In this presentation, the results from a computational study on the performances of the two different designs of CHG3 glass calorimeters are reported. First design reads the signal directly from the edge of the glass plate; the second design utilizes wavelength-shifting fibers to carry the signal out of the glass plate. Each simulation model is a sampling calorimeter with 20 alternating layers of glass and iron absorber. By changing the absorber thickness we tested hadronic as well as electromagnetic capabilities of the calorimeter models.

  11. Fiber optic thermal/fast neutron and gamma ray scintillation detector

    DOEpatents

    Neal, John S.; Mihalczo, John T

    2007-10-30

    A system for detecting fissile and fissionable material originating external to the system includes: a .sup.6Li loaded glass fiber scintillator for detecting thermal neutrons, x-rays and gamma rays; a fast scintillator for detecting fast neutrons, x-rays and gamma rays, the fast scintillator conjoined with the glass fiber scintillator such that the fast scintillator moderates fast neutrons prior to their detection as thermal neutrons by the glass fiber scintillator; and a coincidence detection system for processing the time distributions of arriving signals from the scintillators.

  12. Quenching the scintillation in CF4 Cherenkov gas radiator

    NASA Astrophysics Data System (ADS)

    Blake, T.; D`Ambrosio, C.; Easo, S.; Eisenhardt, S.; Fitzpatrick, C.; Forty, R.; Frei, C.; Gibson, V.; Gys, T.; Harnew, N.; Hunt, P.; Jones, C. R.; Lambert, R. W.; Matteuzzi, C.; Muheim, F.; Papanestis, A.; Perego, D. L.; Piedigrossi, D.; Plackett, R.; Powell, A.; Topp-Joergensen, S.; Ullaland, O.; Websdale, D.; Wotton, S. A.; Wyllie, K.

    2015-08-01

    CF4 is used as a Cherenkov gas radiator in one of the Ring Imaging Cherenkov detectors at the LHCb experiment at the CERN Large Hadron Collider. CF4 is well known to have a high scintillation photon yield in the near and far VUV, UV and in the visible wavelength range. A large flux of scintillation photons in our photon detection acceptance between 200 and 800 nm could compromise the particle identification efficiency. We will show that this scintillation photon emission system can be effectively quenched, consistent with radiationless transitions, with no significant impact on the photons resulting from Cherenkov radiation.

  13. Measurement of the liquid scintillator nonlinear energy response to electron

    NASA Astrophysics Data System (ADS)

    Zhang, Fei-Hong; Yu, Bo-Xiang; Hu, Wei; Yang, Ma-Sheng; Cao, Guo-Fu; Cao, Jun; Zhou, Li

    2015-01-01

    Nonlinearity of the liquid scintillator energy response is a key to measuring the neutrino energy spectrum in reactor neutrino experiments such as Daya Bay and JUNO. We measured the nonlinearity of the linear alkyl benzene based liquid scintillator in the laboratory, which is used in Daya Bay and will be used in JUNO, via the Compton scattering process. By tagging the scattered gamma from the liquid scintillator sample simultaneously at seven angles, the instability of the system was largely cancelled. The accurately measured nonlinearity will improve the precision of the θ13, Δm2, and reactor neutrino spectrum measurements at Daya Bay.

  14. Trigger and electronics issues for scintillating fiber tracking

    SciTech Connect

    Baumbaugh, A.E.

    1994-01-01

    Scintillating Fiber technology has made great advances and has demonstrated great promise for high speed charged particle tracking and triggering. The small detector sizes and fast scintillation floors available, make them very promising for use at high luminosity experiments at today`s and tomorrow`s colliding and fixed target experiments where high rate capability is essential. This paper will discuss some of the system aspects which should be considered by anyone attempting to design a scintillating fiber tracking system and high speed tracking trigger. As the reader will see, seemingly simple decisions can have far reaching effects on overall system performance.

  15. Neutron detector using lithiated glass-scintillating particle composite

    SciTech Connect

    Wallace, Steven; Stephan, Andrew C.; Dai, Sheng; Im, Hee-Jung

    2009-09-01

    A neutron detector composed of a matrix of scintillating particles imbedded in a lithiated glass is disclosed. The neutron detector detects the neutrons by absorbing the neutron in the lithium-6 isotope which has been enriched from the natural isotopic ratio to a commercial ninety five percent. The utility of the detector is optimized by suitably selecting scintillating particle sizes in the range of the alpha and the triton. Nominal particle sizes are in the range of five to twenty five microns depending upon the specific scintillating particle selected.

  16. Method for measuring multiple scattering corrections between liquid scintillators

    DOE PAGESBeta

    Verbeke, J. M.; Glenn, A. M.; Keefer, G. J.; Wurtz, R. E.

    2016-04-11

    In this study, a time-of-flight method is proposed to experimentally quantify the fractions of neutrons scattering between scintillators. An array of scintillators is characterized in terms of crosstalk with this method by measuring a californium source, for different neutron energy thresholds. The spectral information recorded by the scintillators can be used to estimate the fractions of neutrons multiple scattering. With the help of a correction to Feynman's point model theory to account for multiple scattering, these fractions can in turn improve the mass reconstruction of fissile materials under investigation.

  17. Ionization and scintillation of nuclear recoils in gaseous xenon

    NASA Astrophysics Data System (ADS)

    Renner, J.; Gehman, V. M.; Goldschmidt, A.; Matis, H. S.; Miller, T.; Nakajima, Y.; Nygren, D.; Oliveira, C. A. B.; Shuman, D.; Álvarez, V.; Borges, F. I. G.; Cárcel, S.; Castel, J.; Cebrián, S.; Cervera, A.; Conde, C. A. N.; Dafni, T.; Dias, T. H. V. T.; Díaz, J.; Esteve, R.; Evtoukhovitch, P.; Fernandes, L. M. P.; Ferrario, P.; Ferreira, A. L.; Freitas, E. D. C.; Gil, A.; Gómez, H.; Gómez-Cadenas, J. J.; González-Díaz, D.; Gutiérrez, R. M.; Hauptman, J.; Hernando Morata, J. A.; Herrera, D. C.; Iguaz, F. J.; Irastorza, I. G.; Jinete, M. A.; Labarga, L.; Laing, A.; Liubarsky, I.; Lopes, J. A. M.; Lorca, D.; Losada, M.; Luzón, G.; Marí, A.; Martín-Albo, J.; Martínez, A.; Moiseenko, A.; Monrabal, F.; Monserrate, M.; Monteiro, C. M. B.; Mora, F. J.; Moutinho, L. M.; Muñoz Vidal, J.; Natal da Luz, H.; Navarro, G.; Nebot-Guinot, M.; Palma, R.; Pérez, J.; Pérez Aparicio, J. L.; Ripoll, L.; Rodríguez, A.; Rodríguez, J.; Santos, F. P.; dos Santos, J. M. F.; Seguí, L.; Serra, L.; Simón, A.; Sofka, C.; Sorel, M.; Toledo, J. F.; Tomás, A.; Torrent, J.; Tsamalaidze, Z.; Veloso, J. F. C. A.; Villar, J. A.; Webb, R. C.; White, J.; Yahlali, N.

    2015-09-01

    Ionization and scintillation produced by nuclear recoils in gaseous xenon at approximately 14 bar have been simultaneously observed in an electroluminescent time projection chamber. Neutrons from radioisotope α-Be neutron sources were used to induce xenon nuclear recoils, and the observed recoil spectra were compared to a detailed Monte Carlo employing estimated ionization and scintillation yields for nuclear recoils. The ability to discriminate between electronic and nuclear recoils using the ratio of ionization to primary scintillation is demonstrated. These results encourage further investigation on the use of xenon in the gas phase as a detector medium in dark matter direct detection experiments.

  18. Liquid Scintillator based experiments in Neutrinoless Double Beta Decay

    NASA Astrophysics Data System (ADS)

    Nakamura, K.; KamLAND-Zen Collaboration

    2012-08-01

    Recent experiments have confirmed neutrino oscillations. The mass structure of neutrinos is one of the next interesting subjects in neutrino physics. Neutrinoless double beta decay has the potential to investigate the mass structure of neutrinos. Many neutrinoless double beta decay experiments are being proposed and some were introduced at this conference. Here we present neutrinoless double beta decay experiments based on liquid scintillator techniques. SNO+ plans to use 150Nd as the neutrinoless double beta decay isotope dissolved in liquid scintillator, similarly KamLAND-Zen will use 136Xe loaded liquid scintillator. The physics goals, schedule and current status of both experiments were discussed.

  19. Method for measuring multiple scattering corrections between liquid scintillators

    NASA Astrophysics Data System (ADS)

    Verbeke, J. M.; Glenn, A. M.; Keefer, G. J.; Wurtz, R. E.

    2016-07-01

    A time-of-flight method is proposed to experimentally quantify the fractions of neutrons scattering between scintillators. An array of scintillators is characterized in terms of crosstalk with this method by measuring a californium source, for different neutron energy thresholds. The spectral information recorded by the scintillators can be used to estimate the fractions of neutrons multiple scattering. With the help of a correction to Feynman's point model theory to account for multiple scattering, these fractions can in turn improve the mass reconstruction of fissile materials under investigation.

  20. Thin scintillators for ultrafast hard X-ray imaging

    NASA Astrophysics Data System (ADS)

    Wang, Zhehui; Barnes, Cris W.; Kapustinsky, Jon S.; Morris, Chris L.; Nelson, Ron O.; Yang, Fan; Zhang, Liyuan; Zhu, Ren-Yuan

    2015-05-01

    A multilayer thin-scintillator concept is described for ultrafast imaging. The individual layer thickness is determined by the spatial resolution and light attenuation length, the number of layers is determined by the overall efficiency. By coating the scintillators with a high quantum-efficiency photocathode, single X-ray photon detection can be achieved using fast scintillators with low light yield. The fast, efficient sensors, when combined with MCP and novel nanostructed electron amplification schemes, is a possible way towards GHz hard X-ray cameras for a few frames of images.

  1. Rayleigh scattering of linear alkylbenzene in large liquid scintillator detectors

    SciTech Connect

    Zhou, Xiang Zhang, Zhenyu; Liu, Qian; Zheng, Yangheng; Wurm, Michael; Zhang, Qingmin; Ding, Yayun; Zhou, Li; Cao, Jun; Wang, Yifang

    2015-07-15

    Rayleigh scattering poses an intrinsic limit for the transparency of organic liquid scintillators. This work focuses on the Rayleigh scattering length of linear alkylbenzene (LAB), which will be used as the solvent of the liquid scintillator in the central detector of the Jiangmen Underground Neutrino Observatory. We investigate the anisotropy of the Rayleigh scattering in LAB, showing that the resulting Rayleigh scattering length will be significantly shorter than reported before. Given the same overall light attenuation, this will result in a more efficient transmission of photons through the scintillator, increasing the amount of light collected by the photosensors and thereby the energy resolution of the detector.

  2. Calibration of Small Plastic Scintillators for Imaging Applications

    SciTech Connect

    Pozzi, S.

    2005-01-19

    This report presents the results of measurements and simulations performed with 12 small plastic scintillation detectors manufactured by Scionix for imaging applications. The scintillator is equivalent to a Bicron BC-420 plastic scintillator. A gamma calibration is presented to determine the voltage to be applied on each detector to ensure uniform detector operation. Time of flight measurements performed with a Cf-252 source are also presented. Comparisons between experimental data and data from the Monte Carlo simulations show good agreement for time lags of 0 to 70 ns.

  3. A flexible scintillation light apparatus for rare events searches

    NASA Astrophysics Data System (ADS)

    Gironi, L.; Baldazzi, G.; Bonvicini, V.; Campana, R.; Capelli, S.; Evangelista, Y.; Fasoli, M.; Feroci, M.; Fuschino, F.; Labanti, C.; Marisaldi, M.; Previtali, E.; Riganese, L.; Rashevsky, A.; Sisti, M.; Vacchi, A.; Vedda, A.; Zampa, G.; Zampa, N.; Zuffa, M.

    2016-05-01

    FLARES (a Flexible scintillation Light Apparatus for Rare Event Searches) is a project for an innovative detector technology to be applied to rare event searches, and in particular to neutrinoless double beta decay experiments. Its novelty is the enhancement and optimization of the collection of the scintillation light emitted by ultra-pure crystals through the use of arrays of high performance silicon photodetectors cooled to 120 K. This would provide scintillation detectors with ~1% level energy resolution, with the advantages of a technology offering relatively simple low cost mass scalability and powerful background reduction handles, as requested by future neutrinoless double beta decay experimental programs.

  4. Radiation sensitivity of GSO and LSO scintillation detectors

    NASA Astrophysics Data System (ADS)

    Kozma, Peter; Kozma, Petr

    2005-02-01

    Radiation resistance of 4×4×30 mm 3 GSO and LSO imaging scintillation detectors has been studied for low-energy gamma-ray doses of 10 4 Gy (10 6 rad) and 10 5 Gy (10 7 rad). Radiation hardness was determined by the measurement of optical transmission through GSO and LSO scintillation crystals before and after irradiations with 60Co gamma-rays. The results have been analysed in terms of the radiation-induced absorption coefficients and compared with radiation sensitivity measurements of small BGO scintillation crystals. The recovery time of irradiated small GSO and LSO crystals has also been determined.

  5. Quadruple screen test

    MedlinePlus

    ... screen; Multiple marker screening; AFP plus; Triple screen test; AFP maternal; MSAFP; 4-marker screen ... This test is most often done between the 15th and 22nd weeks of the pregnancy. It is most accurate ...

  6. Liquid Scintillator Light Yield Measurements for the SNO+ Experiment

    NASA Astrophysics Data System (ADS)

    Grullon, Sean

    2013-04-01

    The SNO+ experiment is the follow-up to the Sudbury Neutrino Observatory (SNO). The heavy water that was in SNO will be replaced with a liquid scintillator of linear alkylbenzene. SNO+ will have a broad physics program which will include measuring the pep and CNO solar neutrino flux, detecting geo-neutrinos, studying reactor neutrino oscillations, serving as a supernova neutrino detector, and carrying out a search for neutrinoless double beta decay by loading an isotope such as neodymium into the liquid scintillator. Since energy resolution is of profound importance for the experiment, it is extremely important to accurately measure the light yield of the liquid scintillator for different loading percentages of Neodymium. A series of measurements made comparing the relative light yields of different liquid scintillator configurations to a Cherenkov spectrum will be described.

  7. Encapsulated scintillators monitor /sup 3/H-solute concentrations

    SciTech Connect

    Kirk, G.; Gruner, S.

    1982-02-01

    The short range of the /sup 3/H beta allows shielding of microbeds of scintillator by a several um thick coating of a water based gel. Gels may be used which are permeable to a wide variety of tritiated molecules. Thus, the light output of a mixture of the coated beads and a solution of the tritiated compound is proportional to the solution concentration of the tritiated substance. The mixture may also contain particles to which the gel is impermeable, such as cells, vesicles, large proteins, etc., but which can alter the concentration of the tritiated compound by uptake or release. In this case, the light output monitors the fractional uptake of the tritiated material. The design criteria for encapsulating the scintillators and dynamically monitoring the scintillation output are discussed. A simple method for encapsulating plastic scintillator microbeads, suitable for monitoring slow concentration changes, is described and tested.

  8. Scintillation characterization for multiple incoherent uplink Gaussian beams

    NASA Astrophysics Data System (ADS)

    Wu, Wu-Ming; Ning, Yu; Ma, Yan-Xing; Xi, Fen-Jie; Xu, Xiao-Jun

    2014-09-01

    By means of numerical simulations, we analyze the scintillation characterization for multiple incoherent uplink Gaussian beams under weak fluctuations cases. Because truly independent beams are difficult to create, we present a more general but approximate model for the multiple of beams traveling through partially correlated paths. This model compares with wave-optics simulations and highlights the reduced correlation coefficient as the beam separation is increased. The scintillation index of three and six incoherent uplink Gaussian beams is also induced. The result shows that the scintillation index decreases with the increase of beams amount and beam separation. When the beams amount and strength of atmospheric turbulence are fixed, the reduction of scintillation index is affected by the ratio of beams separation and the Fried length. The corresponding physical mechanisms for the results are discussed.

  9. Scintillation effects on radio wave propagation through solar corona

    NASA Technical Reports Server (NTRS)

    Ho, C. M.; Sue, M. K.; Bedrossian, A.; Sniffin, R. W.

    2002-01-01

    When RF waves pass through the solar corona and solar wind regions close to the Sun, strong scintillation effects appear at their amplitude, frequency and phase, especially in the regions very close to the Sun (less than 4 solar radius).

  10. Data analysis in solar neutrinos liquid-scintillator detectors

    NASA Astrophysics Data System (ADS)

    Testera, G.

    2016-04-01

    This paper focuses on the description of some of the methods developed to extract the solar neutrino signal from the background by the two running experiments (Borexino and Kamland) based on the use of a large volume of liquid scintillator.

  11. A scintillator purification plant and fluid handling system for SNO+

    SciTech Connect

    Ford, Richard J.

    2015-08-17

    A large capacity purification plant and fluid handling system has been constructed for the SNO+ neutrino and double-beta decay experiment, located 6800 feet underground at SNOLAB, Canada. SNO+ is a refurbishment of the SNO detector to fill the acrylic vessel with liquid scintillator based on Linear Alkylbenzene (LAB) and 2 g/L PPO, and also has a phase to load natural tellurium into the scintillator for a double-beta decay experiment with {sup 130}Te. The plant includes processes multi-stage dual-stream distillation, column water extraction, steam stripping, and functionalized silica gel adsorption columns. The plant also includes systems for preparing the scintillator with PPO and metal-loading the scintillator for double-beta decay exposure. We review the basis of design, the purification principles, specifications for the plant, and the construction and installations. The construction and commissioning status is updated.

  12. A scintillator purification plant and fluid handling system for SNO+

    NASA Astrophysics Data System (ADS)

    Ford, Richard J.

    2015-08-01

    A large capacity purification plant and fluid handling system has been constructed for the SNO+ neutrino and double-beta decay experiment, located 6800 feet underground at SNOLAB, Canada. SNO+ is a refurbishment of the SNO detector to fill the acrylic vessel with liquid scintillator based on Linear Alkylbenzene (LAB) and 2 g/L PPO, and also has a phase to load natural tellurium into the scintillator for a double-beta decay experiment with 130Te. The plant includes processes multi-stage dual-stream distillation, column water extraction, steam stripping, and functionalized silica gel adsorption columns. The plant also includes systems for preparing the scintillator with PPO and metal-loading the scintillator for double-beta decay exposure. We review the basis of design, the purification principles, specifications for the plant, and the construction and installations. The construction and commissioning status is updated.

  13. First study of nano-composite scintillators under alpha irradiation

    SciTech Connect

    Letant, S; Wang, T

    2005-06-01

    We demonstrate that nano-composite materials based on semiconductor quantum dots have great potential for radiation detection via scintillation. While quantum dots and laser dyes both emit in the visible range at room temperature, the Stokes shift of the dyes is significantly larger. The scintillation output of both systems was studied under alpha irradiation and interpreted using a combination of energy-loss and photon transport Monte Carlo simulation models. The comparison of the two systems, which allows the quantification of the role played by the Stokes shift in the scintillation output, opens up exciting possibilities for a new class of scintillators that would take advantage of the limitless assembly of nano-crystals in large, transparent, and sturdy matrices.

  14. The response of scintillators to heavy ions: 1, Plastics

    SciTech Connect

    McMahan, M.A.

    1987-10-01

    The response of various scintillator detectors to ions of A = 1-84 and energies E/A = 5 to 30 MeV have been measured, and are found to be linear above an energy of 100 MeV. Results are presented for a typical organic plastic scintillator including parametrizations of the data as a function of Z, A, and energy. These results can be used by anyone using scintillators as heavy ion detectors, with one calibration point giving a normalization that allows use of the whole set of curves. The response functions are compared to previous parametrizations at lower energies and discussed in terms of the theory of delta-ray formation in the scintillator.

  15. Final LDRD report : advanced plastic scintillators for neutron detection.

    SciTech Connect

    Vance, Andrew L.; Mascarenhas, Nicholas; O'Bryan, Greg; Mrowka, Stanley

    2010-09-01

    This report summarizes the results of a one-year, feasibility-scale LDRD project that was conducted with the goal of developing new plastic scintillators capable of pulse shape discrimination (PSD) for neutron detection. Copolymers composed of matrix materials such as poly(methyl methacrylate) (PMMA) and blocks containing trans-stilbene (tSB) as the scintillator component were prepared and tested for gamma/neutron response. Block copolymer synthesis utilizing tSBMA proved unsuccessful so random copolymers containing up to 30% tSB were prepared. These copolymers were found to function as scintillators upon exposure to gamma radiation; however, they did not exhibit PSD when exposed to a neutron source. This project, while falling short of its ultimate goal, demonstrated the possible utility of single-component, undoped plastics as scintillators for applications that do not require PSD.

  16. Radiowave Phase Scintillation and Precision Doppler Tracking of Spacecraft

    NASA Technical Reports Server (NTRS)

    Armstrong, J. W.

    1997-01-01

    Phase scintillation cause by propagation through irregularities in the solar wind, ionosphere, and tropospher, introduces noise in spacecraft radio science experiments. The observations reported here are uses to refine the propagation noise model for Doppler tracking of deep space probes.

  17. Multilayer Scintillation Detector for Nuclear Physics Monitoring of Space Weather

    NASA Astrophysics Data System (ADS)

    Batischev, A. G.; Aleksandrin, S. Yu.; Gurov, Yu. B.; Koldashov, S. V.; Lapushkin, S. V.; Mayorov, A. G.

    The physical characteristics of the multilayer scintillation spectrometer (MSS) for identification and energy measurement of cosmic electrons, positrons and nuclei are considered in this paper. This spectrometer is made on the basis of several plastic scintillator plates with various thick viewed by photomultipliers. Two upper layers are strips of orthogonal scintillators. The nuclei energy measurement range is 3 - 100 MeV/nucleon. Spectrometer is planning for space weather monitoring and investigation of solar-magnetospheric and geophysics effects on satellite. MSS time resolution is about 1 microsecond and it can measure the time profiles of fast processes in the Earth's magnetosphere. Spectrometer experimental characteristics were estimated by means of computer simulation. The ionization loss fluctuations, ion charge exchange during pass through detector and, especially, scintillation quenching effect (Bircs effect) were taken into account in calculations.

  18. Scintillation advantages of lowest order Bessel-Gaussian beams

    NASA Astrophysics Data System (ADS)

    Eyyuboğlu, H. T.; Baykal, Y.; Sermutlu, E.; Cai, Y.

    2008-08-01

    For a weak turbulence propagation environment, the scintillation index of the lowest order Bessel-Gaussian beams is formulated. Its triple and single integral versions are presented. Numerical evaluations show that at large source sizes and large width parameters, when compared at the same source size, Bessel-Gaussian beams tend to exhibit lower scintillations than the Gaussian beam scintillations. This advantage is lost however for excessively large width parameters and beyond certain propagation lengths. Large width parameters also cause rises and falls in the scintillation index of off-axis positions toward the edges of the received beam. Comparisons against the fundamental Gaussian beam are made on equal source size and equal power basis.

  19. Time profile of the scintillation from liquid and gaseous xenon

    NASA Astrophysics Data System (ADS)

    Murayama, Ikuko; Nakamura, Shogo

    2014-11-01

    The decay time profile of vacuum ultraviolet scintillation induced by electronic recoils has been studied for liquid and gaseous xenon. The scintillation light from xenon excited by a gamma source was measured by using two vacuum ultraviolet sensitive photomultipliers, one for detecting scintillation and the other for counting photons of weak monochromatic light. The analysis results based on the time-correlated single photon counting method show that the time profile in the 176 nm scintillation decay curve for liquid xenon is consistent with a single exponential component and the decay time constant is 31.5±1.3 ns. This constant does not change significantly for pressure ranges between 90 kPa and 130 kPa. There is no emission wavelength dependence of the decay constant. The result corresponds to an average on electronic recoil energies up to 1.3 MeV.

  20. UCN detection with 6Li-doped glass scintillators

    NASA Astrophysics Data System (ADS)

    Ban, G.; Bodek, K.; Lefort, T.; Naviliat-Cuncic, O.; Pierre, E.; Plonka, C.; Rogel, G.

    2009-12-01

    We report the results of test measurements aimed at determining the performance of 6Li-doped glass scintillators for ultra-cold neutron detection. Investigations have mainly focused on the reduction of the gamma-ray sensitivity of the scintillators. The probability of gamma interaction has been considerably lowered using very thin glasses. For signals corresponding to full-energy deposition, a background count rate of 8×10 -3 s -1 was obtained for a shielded 0.5 cm 3 GS10 scintillator located near the PF2 turbine at ILL. The neutron-gamma separation has further been improved using a stack with an 6Li-depleted scintillator and an 6Li-enriched one. Neutron captures leading to partial energy deposition (so-called "edge events") have strongly been reduced resulting in a clear separation between the neutron and the gamma contributions.

  1. 21 CFR 892.1100 - Scintillation (gamma) camera.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) Identification. A scintillation (gamma) camera is a device intended to image the distribution of radionuclides in the body by means of a photon radiation detector. This generic type of device may include...

  2. 21 CFR 892.1100 - Scintillation (gamma) camera.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Identification. A scintillation (gamma) camera is a device intended to image the distribution of radionuclides in the body by means of a photon radiation detector. This generic type of device may include...

  3. 21 CFR 892.1100 - Scintillation (gamma) camera.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) Identification. A scintillation (gamma) camera is a device intended to image the distribution of radionuclides in the body by means of a photon radiation detector. This generic type of device may include...

  4. 21 CFR 892.1100 - Scintillation (gamma) camera.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Identification. A scintillation (gamma) camera is a device intended to image the distribution of radionuclides in the body by means of a photon radiation detector. This generic type of device may include...

  5. Lanthanum halide scintillators for time-of-flight 3-D pet

    DOEpatents

    Karp, Joel S.; Surti, Suleman

    2008-06-03

    A Lanthanum Halide scintillator (for example LaCl.sub.3 and LaBr.sub.3) with fast decay time and good timing resolution, as well as high light output and good energy resolution, is used in the design of a PET scanner. The PET scanner includes a cavity for accepting a patient and a plurality of PET detector modules arranged in an approximately cylindrical configuration about the cavity. Each PET detector includes a Lanthanum Halide scintillator having a plurality of Lanthanum Halide crystals, a light guide, and a plurality of photomultiplier tubes arranged respectively peripherally around the cavity. The good timing resolution enables a time-of-flight (TOF) PET scanner to be developed that exhibits a reduction in noise propagation during image reconstruction and a gain in the signal-to-noise ratio. Such a PET scanner includes a time stamp circuit that records the time of receipt of gamma rays by respective PET detectors and provides timing data outputs that are provided to a processor that, in turn, calculates time-of-flight (TOF) of gamma rays through a patient in the cavity and uses the TOF of gamma rays in the reconstruction of images of the patient.

  6. Digital breast tomosynthesis (3D-mammography) screening: A pictorial review of screen-detected cancers and false recalls attributed to tomosynthesis in prospective screening trials.

    PubMed

    Houssami, Nehmat; Lång, Kristina; Bernardi, Daniela; Tagliafico, Alberto; Zackrisson, Sophia; Skaane, Per

    2016-04-01

    This pictorial review highlights cancers detected only at tomosynthesis screening and screens falsely recalled in the course of breast tomosynthesis screening, illustrating both true-positive (TP) and false-positive (FP) detection attributed to tomosynthesis. Images and descriptive data were used to characterise cases of screen-detection with tomosynthesis, sourced from prospective screening trials that performed standard (2D) digital mammography (DM) and tomosynthesis (3D-mammography) in the same screening participants. Exemplar cases from four trials highlight common themes of relevance to screening practice including: the type of lesions frequently made more conspicuous or perceptible by tomosynthesis (spiculated masses, and architectural distortions); the histologic findings (both TP and FP) of tomosynthesis-only detection; and the need to extend breast work-up protocols (additional imaging including ultrasound and MRI, and tomosynthesis-guided biopsy) if tomosynthesis is adopted for primary screening. PMID:27017251

  7. Scintillating fiber ribbon development for the D0 upgrade

    SciTech Connect

    Ramberg, E.J.

    1998-11-01

    As part of general upgrade of the D0 detector, a scintillating fiber tracker is being developed at Fermilab. This note describes the development of ribbons of scintillating fibers as the first step in production of the active element of this tracker. Methods for testing the quality of these ribbons and of mounting them on the support structure are briefly described. {copyright} {ital 1998 American Institute of Physics.}

  8. Initial tests of a high resolution Scintillating Fibre (SCIFI) tracker

    NASA Astrophysics Data System (ADS)

    Atkinson, M.; Fent, J.; Fisher, C.; Freund, P.; Hughes, P.; Kirkby, J.; Osthoff, A.; Pretzl, K.

    1987-03-01

    We present our initial measurements of high resolution particle tracking in scintillating fibre (SCIFI) detectors. The scintillator under study is a glass, designated GS1, which is doped with the cerium (Ce 3+) emitter. We conclude from our measurements that present SCIFI detectors can be successfully used as small-volume "active" targets, but that further developments are necessary before this technique can be applied to high precision tracking in collider detectors.

  9. Refractive Interstellar Scintillation for Flux Density Variations of Two Pulsars

    NASA Astrophysics Data System (ADS)

    Zhou, Ai-Zhi; Wu, Xin-Ji; Esamdin, A.

    2003-08-01

    The flux density structure functions of PSRs B0525+21 and B2111+46 are calculated with the refractive interstellar scintillation (RISS) theory. The theoretical curves are in good agreement with observations [Astrophys. J. 539 (2000) 300] (hereafter S2000). The spectra of the electron density fluctuations both are of Kolmogorov spectra. We suggest that the flux density variations observed for these two pulsars are attributed to refractive interstellar scintillation, not to intrinsic variability.

  10. Fluorescence decay-time constants in organic liquid scintillators

    SciTech Connect

    Marrodan Undagoitia, T.; Feilitzsch, F. von; Oberauer, L.; Potzel, W.; Ulrich, A.; Winter, J.; Wurm, M.

    2009-04-15

    The fluorescence decay-time constants have been measured for several scintillator mixtures based on phenyl-o-xylylethane (PXE) and linear alkylbenzene (LAB) solvents. The resulting values are of relevance for the physics performance of the proposed large-volume liquid scintillator detector Low Energy Neutrino Astronomy (LENA). In particular, the impact of the measured values to the search for proton decay via p{yields}K{sup +}{nu} is evaluated in this work.

  11. High effective atomic number polymer scintillators for gamma ray spectroscopy

    SciTech Connect

    Cherepy, Nerine Jane; Sanner, Robert Dean; Payne, Stephen Anthony; Rupert, Benjamin Lee; Sturm, Benjamin Walter

    2014-04-15

    A scintillator material according to one embodiment includes a bismuth-loaded aromatic polymer having an energy resolution at 662 keV of less than about 10%. A scintillator material according to another embodiment includes a bismuth-loaded aromatic polymer having a fluor incorporated therewith and an energy resolution at 662 keV of less than about 10%. Additional systems and methods are also presented.

  12. Research to Operations of Ionospheric Scintillation Detection and Forecasting

    NASA Astrophysics Data System (ADS)

    Jones, J.; Scro, K.; Payne, D.; Ruhge, R.; Erickson, B.; Andorka, S.; Ludwig, C.; Karmann, J.; Ebelhar, D.

    Ionospheric Scintillation refers to random fluctuations in phase and amplitude of electromagnetic waves caused by a rapidly varying refractive index due to turbulent features in the ionosphere. Scintillation of transionospheric UHF and L-Band radio frequency signals is particularly troublesome since this phenomenon can lead to degradation of signal strength and integrity that can negatively impact satellite communications and navigation, radar, or radio signals from other systems that traverse or interact with the ionosphere. Although ionospheric scintillation occurs in both the equatorial and polar regions of the Earth, the focus of this modeling effort is on equatorial scintillation. The ionospheric scintillation model is data-driven in a sense that scintillation observations are used to perform detection and characterization of scintillation structures. These structures are then propagated to future times using drift and decay models to represent the natural evolution of ionospheric scintillation. The impact on radio signals is also determined by the model and represented in graphical format to the user. A frequency scaling algorithm allows for impact analysis on frequencies other than the observation frequencies. The project began with lab-grade software and through a tailored Agile development process, deployed operational-grade code to a DoD operational center. The Agile development process promotes adaptive promote adaptive planning, evolutionary development, early delivery, continuous improvement, regular collaboration with the customer, and encourage rapid and flexible response to customer-driven changes. The Agile philosophy values individuals and interactions over processes and tools, working software over comprehensive documentation, customer collaboration over contract negotiation, and responding to change over following a rigid plan. The end result was an operational capability that met customer expectations. Details of the model and the process of

  13. Gamma ray spectroscopy in astrophysics: Future role of scintillation detectors

    NASA Technical Reports Server (NTRS)

    Kurfess, J. D.

    1978-01-01

    The future role of conventional scintillation detector telescopes for line gamma-ray astronomy is discussed. Although the energy resolution of the germanium detectors now being used by several groups is clearly desirable, the larger effective areas and higher efficiencies available with scintillation detectors is advantageous for many observations. This is particularly true for those observations of astrophysical phenomena where significant line broadening is expected.

  14. Lanthanum halide nanoparticle scintillators for nuclear radiation detection

    SciTech Connect

    Guss, Paul; Guise, Ronald; Yuan, Ding; Mukhopadhyay, Sanjoy; O'Brien, Robert; Lowe, Daniel; Kang, Zhitao; Menkara, Hisham; Nagarkar, Vivek V.

    2013-01-01

    Nanoparticles with sizes <10 nm were fabricated and characterized for their nanocomposite radiation detector properties. This work investigated the properties of several nanostructured radiation scintillators, in order to determine the viability of using scintillators employing nanostructured lanthanum tribromide, lanthanum trifluoride, or cerium tribromide. Preliminary results of this investigation are consistent with the idea that these materials have an intrinsic response to nuclear radiation that may be correlated to the energy of the incident radiation.

  15. Lanthanum halide nanoparticle scintillators for nuclear radiation detection

    SciTech Connect

    Guss, Paul; Guise, Ronald; O'Brien, Robert; Lowe, Daniel; Kang Zhitao; Menkara, Hisham; Nagarkar, Vivek V.

    2013-02-14

    Nanoparticles with sizes <10 nm were fabricated and characterized for their nanocomposite radiation detector properties. This work investigated the properties of several nanostructured radiation scintillators, in order to determine the viability of using scintillators employing nanostructured lanthanum trifluoride. Preliminary results of this investigation are consistent with the idea that these materials have an intrinsic response to nuclear radiation that may be correlated to the energy of the incident radiation.

  16. Comparison of scintillators for single shot imaging of laser accelerated proton beams

    NASA Astrophysics Data System (ADS)

    Cook, Nathan

    2012-03-01

    The application of intense laser pulses incident on specialized targets provides exciting new means for generating energetic beams of protons and ions. Recent work has demonstrated the utility of these beams of particles in a variety of applications, from inertial confinement fusion to radiation therapy. These applications require precise control, and subsequently precise feedback from the beam. Imaging techniques can provide the necessary shot-to-shot characterization to be effective as diagnostics. However, the utility of imaging methods scales with the capability of scintillating materials to emit well characterized and consistent radiation upon irradiance by a charged particle beam. We will discuss three candidates for an ideal diagnostic for MeV range protons and light ions. CsI:Tl^+ and Al2O3:Cr^3+ are two inorganic scintillators which exhibit excellent response to hadrons in this energy range. They are compared with the combination diagnostic micro-channel plate with a P43 phosphor screen, which offers advantages in refresh rate and resolution over direct exposure methods. Ultimately we will determine which candidate performs optimally as part of a robust, inexpensive diagnostic for laser accelerated protons and light ions.

  17. Ceramic scintillator-coupled linear array PIN photodiode for X-ray scanner

    NASA Astrophysics Data System (ADS)

    Kim, Kwang Hyun; Kang, Dong-Wan; Cho, Gyuseong; Kim, Do Kyung

    2007-08-01

    In order to design the full system of dual-energy X-ray scanner, each component of the system has been fabricated and tested. The high-energy X-ray detector modules used a ceramic scintillator of Eu 3+-doped (Gd,Y) 2O 3, manufactured using Glycine Nitrate Process (GNP). This was coupled to a 16-channel linear array PIN-type photodiode. The low-energy module was a commercially available Lanex Regular screen that was also coupled to a 16-channel linear array PIN-type photodiode. The 16-channel linear array PIN-type photodiode of 1.5 mm×3.2 mm was fabricated in the process of Electronics and Telecommunications Research Institute (ETRI). With a data acquisition system, signal-to-noise ratio was measured at low X-ray energy and low photon flux to evaluate each scintillator-coupled detector module. Through the experiment results and analysis, we inspected each component of the system as a dual-energy single-exposure X-ray scanner.

  18. Iterative reconstruction for pet scanners with continuous scintillators.

    PubMed

    Iriarte, Ana; Caffarena, Gabriel; Lopez-Fernandez, Mariano; Garcia-Carmona, Rodrigo; Otero, Abraham; Sorzano, Carlos O S; Marabini, Roberto

    2015-08-01

    Several technical developments have led to a comeback of the continuous scintillators in positron emission tomography (PET). Important differences exist between the resurgent continuous scintillators and the prevailing pixelated devices, which can translate into certain advantages of the former over the latter. However, if the peculiarities of the continuous scintillators are not considered in the iterative reconstruction in which the measured data is converted to images, these advantages will not be fully exploited. In this paper, we review which those peculiarities are and how they have been considered in the literature of PET reconstruction. In light of this review, we propose a new method to compute one of the key elements of the iterative schemes, the system matrix. Specifically, we substitute the traditional Gaussian approach to the so-called uncertainty term by a more general Monte Carlo estimation, and account for the effect of the optical photons, which cannot be neglected in continuous-scintillators devices. Finally, we gather in a single scheme all the elements of the iterative reconstruction that have been individually reformulated, in this or previous works, for continuous scintillators, providing the first reconstruction framework fully adapted to this type of detectors. The preliminary images obtained for a commercially available PET scanner show the benefits of adjusting the reconstruction to the nature of the scintillators. PMID:26736742

  19. Scintillator probe for lost alpha measurements in JET

    SciTech Connect

    Baeumel, S.; Werner, A.; Semler, R.; Mukherjee, S.; Darrow, D.S.; Ellis, R.; Cecil, F.E.; Pedrick, L.; Altmann, H.; Kiptily, V.; Gafert, J.

    2004-10-01

    Good confinement of alpha particles in a large magnetic fusion device is a precondition for building a magnetic fusion reactor. The direct measurement of alpha particle losses is of particular interest. Appropriate diagnostics are now being prepared for the Joint European Torus tokamak: a scintillator probe and a set of Faraday cups. Both systems are capable of measuring charged fusion products and ion cyclotron resonance heating tail ions. The design of the lost alpha particle scintillator probe is in the scope of this article. It will allow the detection of particles with a gyroradius between 20 and 140 mm (15% resolution) and a pitch angle between 30 deg. and 86 deg. (5% resolution). As scintillating material P56 will be used. The light emitted by the scintillator caused by charged particles that pass the collimator and hit the scintillator will be detected via a set of optical lenses and a coherent image fiber bundle with a charge coupled device camera and a photomultiplier array. In the following the present design of the scintillator probe with emphasis on the performance of the system, structural resistance against plasma disruptions, and the requirements on the heat protection against plasma and neutral beam induced thermal loads will be described.

  20. Response of plastic scintillators to low-energy photons

    NASA Astrophysics Data System (ADS)

    Peralta, Luis; Rêgo, Florbela

    2014-08-01

    Diagnostic radiology typically uses x-ray beams between 25 and 150 kVp. Plastic scintillation detectors (PSDs) are potentially successful candidates as field dosimeters but careful selection of the scintillator is crucial. It has been demonstrated that they can suffer from energy dependence in the low-energy region, an undesirable dosimeter characteristic. This dependence is partially due to the nonlinear light yield of the scintillator to the low-energy electrons set in motion by the photon beam. In this work, PSDs made of PMMA, PVT or polystyrene were studied for the x-ray beam range 25 to 100 kVp. For each kVp data has been acquired for additional aluminium filtrations of 0.5, 1.0, 2.0 and 4.0 mm. Absolute dose in the point of measurement was obtained with an ionization chamber calibrated to dose in water. From the collected data, detector sensitivities were obtained as function of the beam kVp and additional filtration. Using Monte Carlo simulations relative scintillator sensitivities were computed. For some of the scintillators these sensitivities show strong energy-dependence for beam average energy below 35 keV for each additional filtration but fair constancy above. One of the scintillators (BC-404) has smaller energy-dependence at low photon average energy and could be considered a candidate for applications (like mammography) where beam energy has small span.