Science.gov

Sample records for shoshone county id

  1. 78 FR 4377 - Idaho Panhandle National Forests, Coeur d'Alene River Ranger District, Shoshone County, ID...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ...The Forest Service will prepare an Environmental Impact Statement (EIS) on a proposal to accomplish vegetation management in the Beaver Creek Resource Area, which is located on National Forest System lands administered by the Idaho Panhandle National Forests in Shoshone County, Idaho. The proposed action would include timber harvest (commercial thin, shelterwood, improvement cut, and seed tree......

  2. 76 FR 29784 - Notice of Realty Action; Direct Sale of Public Lands in Jerome County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ... Bureau of Land Management Notice of Realty Action; Direct Sale of Public Lands in Jerome County, ID... location identified in the ADDRESSES section above. Normal business hours are 7:45 a.m. to 4:30 p.m...(a) and (c). Ruth A. Miller, Shoshone Field Manager. BILLING CODE 4310-GG-P...

  3. 76 FR 22076 - Bussel 484, Idaho Panhandle National Forests, Idaho, Shoshone County

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ... in the Federal Register (73 FR 12413) on March 7, 2008, and the notice for the Final EIS (73 FR 24279... Forest Service Bussel 484, Idaho Panhandle National Forests, Idaho, Shoshone County AGENCY: Forest...: The USDA Forest Service will prepare a supplemental environmental impact statement (SEIS) for...

  4. 78 FR 35602 - Coeur d'Alene Basin Restoration Plan, Kootenai, Shoshone and Benewah Counties, Idaho

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-13

    ... Wildlife Service Coeur d'Alene Basin Restoration Plan, Kootenai, Shoshone and Benewah Counties, Idaho... Department of Agriculture (USDA), Coeur d'Alene Indian Tribe (Tribe), and the State of Idaho (State) intend... related to the Coeur d'Alene Basin Restoration Plan by any of the following methods: Web site:...

  5. North Fork well, Shoshone National Forest, Park County, Wyoming

    SciTech Connect

    Not Available

    1984-01-01

    A summary of the draft environmental impact statement for a proposed exploratory oil drilling operation in Shoshone National Forest in Wyoming describes the drilling equipment and support facilities required for the operation. Marathon Oil Company's purpose is to test the gas and oil potential of underlying geologic structures. Although Marathon plans a reclamation and revegetation program, there would be erosion during the operation. Noise from the drilling and helicopter activity would disrupt wildlife and vacationers in nearby Yellowstone Park. Confrontations with the grizzly bear population would increase. The legal mandate for the assessment was the Mineral Leasing Act of 1920.

  6. 75 FR 65649 - Notice of Realty Action: Segregation To Consider Proposed Sale of Public Lands in Blaine County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... Bureau of Land Management Notice of Realty Action: Segregation To Consider Proposed Sale of Public Lands in Blaine County, ID AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action. SUMMARY: The Bureau of Land Management (BLM), Shoshone Field Office, proposes to sell a parcel of...

  7. 1. GENERAL VIEW OF SHOSHONE HYDROELECTRIC PLANT IN GLENWOOD CANYON, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. GENERAL VIEW OF SHOSHONE HYDROELECTRIC PLANT IN GLENWOOD CANYON, VIEW TO THE NORTHEAST ALONG U.S. 6 AND THE COLORADO RIVER. - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

  8. 8. SHOSHONE HYDROELECTRIC PLANT, WEST AND SOUTH ELEVATIONS, OFFICE BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. SHOSHONE HYDROELECTRIC PLANT, WEST AND SOUTH ELEVATIONS, OFFICE BUILDING TO THE LEFT; VIEW TO THE NORTHEAST. - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

  9. JORDAN CREEK STUDY, OWYHEE COUNTY, ID IN 1975-1976

    EPA Science Inventory

    A set of 3 intensive surveys was completed on Jordan Creek in Owyhee County, ID (17050108) during August and October 1975 and June 1976. Studies were conducted to determine the water quality condition of the stream and to assess the impact of pollution sources. The study includ...

  10. 78 FR 4869 - Notice of Intent To Collect Fees on Public Land in Clark County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... Bureau of Land Management Notice of Intent To Collect Fees on Public Land in Clark County, ID AGENCY... County, ID. SUMMARY: Pursuant to applicable provisions of the Federal Lands Recreation Enhancement Act... reservation fee for large group sites at the Birch Creek Campground in Clark County, ID. Under Section 2(2)...

  11. 11. SHOSHONE INTAKE DAM, VIEW TO THE NORTHWEST. RESTROOM BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. SHOSHONE INTAKE DAM, VIEW TO THE NORTHWEST. RESTROOM BUILDING AND STEAM CLEANER BUILDING ARE SEEN BELOW THE WEST SPAN OF THE BRIDGE; HOIST HOUSE AND CABLEWAY TOWER APE ABOVE CENTER. - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

  12. 5. SHOSHONE HYDROELECTRIC PLANT, SOUTH AND EAST ELEVATIONS, VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. SHOSHONE HYDROELECTRIC PLANT, SOUTH AND EAST ELEVATIONS, VIEW TO WEST; MACHINE REPAIR SHOP TO THE RIGHT, OFFICE BUILDING AND 115 KV SUBSTATION TO THE LEFT. - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

  13. 7. SHOSHONE HYDROELECTRIC PLANT, WEST ELEVATION OF MAIN BUILDING TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. SHOSHONE HYDROELECTRIC PLANT, WEST ELEVATION OF MAIN BUILDING TO THE LEFT, NORTH ELEVATION OF OFFICE BUILDING TO THE RIGHT, VIEW TO THE EAST. CONCRETE 'PATH' IN FOREGROUND IS THE CONDUIT THROUGH WHICH POWER CABLES RUN FROM THE TRANSFORMERS TO THE 115 KV SUBSTATION. - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

  14. 4. SHOSHONE HYDROELECTRIC PLANT, SOUTH ELEVATION; TWIN PENSTOCKS AND FOREBAY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. SHOSHONE HYDROELECTRIC PLANT, SOUTH ELEVATION; TWIN PENSTOCKS AND FOREBAY ABOVE THE PLANT; HOIST HOUSE AND NORTH CABLEWAY TOWER ABOVE THE SPILLWAY TO THE RIGHT; TAIL RACE BELOW U.S. HIGHWAY 6 BRIDGE. - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

  15. 75 FR 39580 - Notice of Realty Action; Direct Sale of Public Lands in Minidoka County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ... Bureau of Land Management Notice of Realty Action; Direct Sale of Public Lands in Minidoka County, ID... Management (BLM) proposes to sell four parcels of public land totaling 262.11 acres in Minidoka County, Idaho... S., R. 24 E., Sec. 4, lots 3 and 4. The area described contains 262.11 acres in Minidoka County....

  16. 76 FR 11264 - Notice of Realty Action: Proposed Direct Sale of Public Land in Shoshone County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ...: Written comments concerning this proposed sale may be submitted to Field Manager, BLM Coeur d'Alene Field Office, 3815 Schreiber Way, Coeur d'Alene, Idaho 83815. FOR FURTHER INFORMATION CONTACT: Janna Paronto, Realty Specialist, at 3815 Schreiber Way, Coeur d'Alene, Idaho 83815 or phone (208)...

  17. 77 FR 64352 - Notice of Temporary Closure of Public Lands in Custer County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ...:00 p.m. MST, at the Challis Field Office and also on the BLM Idaho Web site at: http://www.blm.gov/id... Bureau of Land Management Notice of Temporary Closure of Public Lands in Custer County, ID AGENCY: Bureau... CFR 8364.1. Joe Kraayenbrink, Idaho Falls District Manager. BILLING CODE 4310-GG-P...

  18. 78 FR 20135 - Notice of Temporary Closure on Public Lands in Boise County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-03

    ... Bureau of Land Management Notice of Temporary Closure on Public Lands in Boise County, ID AGENCY: Bureau... 83705 and on the BLM- Idaho Web site: http://www.blm.gov/id/st/en/advisories-closures.html . The BLM...-7; 43 CFR 8364.1. Matthew McCoy, Four Rivers Assistant Field Manager. BILLING CODE 4310-GG-P...

  19. WATER QUALITY STATUS REPORT, CONWAY GULCH, CANYON COUNTY, ID, 1981-1982

    EPA Science Inventory

    The ID Division of Environment (DOE) conducted a water quality survey of conway Gulch, Canyon County, ID (17050114) from April 1981 through March 1982. A total of 12,880 critical erosion acres are included in the drainage area of Conway Gulch. Baseline suspended sediment loadin...

  20. 75 FR 71143 - Notice of Realty Action: Direct Sale of Public Land in Blaine County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-22

    ... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Land in Blaine County, ID AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action. SUMMARY: The Bureau of Land Management (BLM) proposes to sell a parcel of public land totaling 17 acres in Blaine County, Idaho, to...

  1. 75 FR 35083 - Notice of Realty Action; Direct Sale of Public Lands in Lincoln County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ... Bureau of Land Management Notice of Realty Action; Direct Sale of Public Lands in Lincoln County, ID AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action. SUMMARY: The Bureau of Land Management (BLM) proposes to sell a parcel of public land totaling 40 acres in Lincoln County, Idaho, to...

  2. 75 FR 41232 - Deer Flat National Wildlife Refuge, Canyon, Owyhee, Payette, and Washington Counties, ID; Malheur...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Fish and Wildlife Service Deer Flat National Wildlife Refuge, Canyon, Owyhee, Payette, and Washington Counties, ID; Malheur County, OR AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of...

  3. 75 FR 45661 - Notice of Permanent Closure on Public Lands in Ada County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Bureau of Land Management Notice of Permanent Closure on Public Lands in Ada County, ID AGENCY: Bureau of...., Boise Meridian, Ada County, Idaho, in an area containing approximately 72 acres. This closure...

  4. 78 FR 39767 - Notice of Realty Action: Direct Sale of Public Land in Blaine County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Land in Blaine County, ID AGENCY... Blaine County, Idaho, to the Point of Rocks Ranch, LLC (PORR), at not less than the appraised fair market value of $3,220. DATES: Comments regarding the proposed sale must be received by the BLM before...

  5. 76 FR 41196 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) will meet in Thermopolis, Wyoming...: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest Supervisor's...

  6. 76 FR 22672 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) will meet in Thermopolis, Wyoming... CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest...

  7. 77 FR 56607 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) is holding a meeting on September... INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest...

  8. 77 FR 55800 - Foreign-Trade Zone 242-Boundary County, ID; Application for Subzone AREVA Enrichment Services...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... Foreign-Trade Zones Board Foreign-Trade Zone 242--Boundary County, ID; Application for Subzone AREVA Enrichment Services, LLC; Bonneville County, ID An application has been submitted to the Foreign-Trade Zones..., Executive Secretary. BILLING CODE 3510-DS-P...

  9. 75 FR 22625 - Notice of Realty Action; Direct Sale of Public Land in Jerome County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... Bureau of Land Management Notice of Realty Action; Direct Sale of Public Land in Jerome County, ID AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Realty Action. SUMMARY: To resolve an... for direct (non-competitive) sale to Todd and Bridget Buschhorn under the provisions of the...

  10. Modeling Approach/Strategy for Corrective Action Unit 99: Rainier Mesa and Shoshone Mountain, Nevada Test Site, Nye County, Nevada, Revision 1, with ROTC-1

    SciTech Connect

    Greg Ruskauff

    2008-06-01

    This document describes an approach for preliminary (Phase I) flow and transport modeling for the Rainier Mesa/Shoshone Mountain (RMSM) Corrective Action Unit (CAU). This modeling will take place before the planned Phase II round of data collection to better identify the remaining data gaps before the fieldwork begins. Because of the geologic complexity, limited number of borings, and large vertical gradients, there is considerable uncertainty in the conceptual model for flow; thus different conceptual models will be evaluated, in addition to different framework and recharge models. The transport simulations will not be used to formally calculate the Contaminant Boundary at this time. The modeling (Phase II) will occur only after the available data are considered sufficient in scope and quality.

  11. A Hydrostrat Model and Alternatives for Groundwater Flow and Contaminant Transport Model of Corrective Action Unit 99: Rainer Mesa-Shoshone Mountain, Nye County, Nevada

    SciTech Connect

    NSTec Geotechnical Sciences Group

    2007-03-01

    The three-dimensional hydrostratigraphic framework model for the Rainier Mesa-Shoshone Mountain Corrective Action Unit was completed in Fiscal Year 2006. The model extends from eastern Pahute Mesa in the north to Mid Valley in the south and centers on the former nuclear testing areas at Rainier Mesa, Aqueduct Mesa, and Shoshone Mountain. The model area also includes an overlap with the existing Underground Test Area Corrective Action Unit models for Yucca Flat and Pahute Mesa. The model area is geologically diverse and includes un-extended yet highly deformed Paleozoic terrain and high volcanic mesas between the Yucca Flat extensional basin on the east and caldera complexes of the Southwestern Nevada Volcanic Field on the west. The area also includes a hydrologic divide between two groundwater sub-basins of the Death Valley regional flow system. A diverse set of geological and geophysical data collected over the past 50 years was used to develop a structural model and hydrostratigraphic system for the model area. Three deep characterization wells, a magnetotelluric survey, and reprocessed gravity data were acquired specifically for this modeling initiative. These data and associated interpretive products were integrated using EarthVision{reg_sign} software to develop the three-dimensional hydrostratigraphic framework model. Crucial steps in the model building process included establishing a fault model, developing a hydrostratigraphic scheme, compiling a drill-hole database, and constructing detailed geologic and hydrostratigraphic cross sections and subsurface maps. The more than 100 stratigraphic units in the model area were grouped into 43 hydrostratigraphic units based on each unit's propensity toward aquifer or aquitard characteristics. The authors organized the volcanic units in the model area into 35 hydrostratigraphic units that include 16 aquifers, 12 confining units, 2 composite units (a mixture of aquifer and confining units), and 5 intrusive confining units. The underlying pre-Tertiary rocks are divided into six hydrostratigraphic units, including three aquifers and three confining units. Other units include an alluvial aquifer and a Mesozoic-age granitic confining unit. The model depicts the thickness, extent, and geometric relationships of these hydrostratigraphic units ('layers' in the model). The model also incorporates 56 Tertiary normal faults and 4 Mesozoic thrust faults. The complexity of the model area and the non-uniqueness of some of the interpretations incorporated into the base model made it necessary to formulate alternative interpretations for some of the major features in the model. Four of these alternatives were developed so they can be modeled in the same fashion as the base model. This work was done for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Underground Test Area Subproject of the Environmental Restoration Project.

  12. 76 FR 12317 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) will meet in Thermopolis, Wyoming... Broadway, Thermopolis, Wyoming. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory...

  13. 76 FR 3081 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) will hold a conference call on.... FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator,...

  14. 75 FR 55539 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee will meet in Thermopolis, Wyoming....

  15. Predevelopment Water-Level Contours for Aquifers in the Rainier Mesa and Shoshone Mountain area of the Nevada Test Site, Nye County, Nevada

    USGS Publications Warehouse

    Fenelon, Joseph M.; Laczniak, Randell J.; Halford, Keith J.

    2008-01-01

    Contaminants introduced into the subsurface of the Nevada Test Site at Rainier Mesa and Shoshone Mountain by underground nuclear testing are of concern to the U.S. Department of Energy and regulators responsible for protecting human health and safety. Although contaminants were introduced into low-permeability rocks above the regional flow system, the potential for contaminant movement away from the underground test areas and into the accessible environment is greatest by ground-water transport. The primary hydrologic control on this transport is evaluated and examined through a series of contour maps developed to represent the water-level distribution within each of the major aquifers underlying the area. Aquifers were identified and their extents delineated by merging and analyzing multiple hydrostratigraphic framework models developed by other investigators from existing geologic information. The contoured water-level distribution in each major aquifer was developed from a detailed evaluation and assessment of available water-level measurements. Multiple spreadsheets that accompany this report provide pertinent water-level and geologic data by well or drill hole. Aquifers are mapped, presented, and discussed in general terms as being one of three aquifer types?volcanic aquifer, upper carbonate aquifer, or lower carbonate aquifer. Each of these aquifer types was subdivided and mapped as independent continuous and isolated aquifers, based on the continuity of its component rock. Ground-water flow directions, as related to the transport of test-generated contaminants, were developed from water-level contours and are presented and discussed for each of the continuous aquifers. Contoured water-level altitudes vary across the study area and range from more than 5,000 feet in the volcanic aquifer beneath a recharge area in the northern part of the study area to less than 2,450 feet in the lower carbonate aquifer in the southern part of the study area. Variations in water-level altitudes within any single continuous aquifer range from a few hundred feet in a lower carbonate aquifer to just more than 1,100 feet in a volcanic aquifer. Flow directions throughout the study area are dominantly southward with minor eastward or westward deviations. Primary exceptions are westward flow in the northern part of the volcanic aquifer and eastward flow in the eastern part of the lower carbonate aquifer. Northward flow in the upper and lower carbonate aquifers in the northern part of the study area is possible but cannot be substantiated because data are lacking. Interflow between continuous aquifers is evaluated and mapped to define major flow paths. These flow paths delineate tributary flow systems, which converge to form the regional ground-water flow system. The implications of these tributary flow paths in controlling transport away from the underground test areas at Rainier Mesa and Shoshone Mountain are discussed. The obvious data gaps contributing to uncertainties in the delineation of aquifers and development of water-level contours are identified and evaluated.

  16. Predevelopment Water-Level Contours for Aquifers in the Rainier Mesa and Shoshone Mountain area of the Nevada Test Site, Nye County, Nevada

    SciTech Connect

    Joseph M. Fenelon; Randell J. Laczniak; and Keith J. Halford

    2008-06-24

    Contaminants introduced into the subsurface of the Nevada Test Site at Rainier Mesa and Shoshone Mountain by underground nuclear testing are of concern to the U.S. Department of Energy and regulators responsible for protecting human health and safety. Although contaminants were introduced into low-permeability rocks above the regional flow system, the potential for contaminant movement away from the underground test areas and into the accessible environment is greatest by ground-water transport. The primary hydrologic control on this transport is evaluated and examined through a series of contour maps developed to represent the water-level distribution within each of the major aquifers underlying the area. Aquifers were identified and their extents delineated by merging and analyzing multiple hydrostratigraphic framework models developed by other investigators from existing geologic information. The contoured water-level distribution in each major aquifer was developed from a detailed evaluation and assessment of available water-level measurements. Multiple spreadsheets that accompany this report provide pertinent water-level and geologic data by well or drill hole. Aquifers are mapped, presented, and discussed in general terms as being one of three aquifer types—volcanic aquifer, upper carbonate aquifer, or lower carbonate aquifer. Each of these aquifer types was subdivided and mapped as independent continuous and isolated aquifers, based on the continuity of its component rock. Ground-water flow directions, as related to the transport of test-generated contaminants, were developed from water-level contours and are presented and discussed for each of the continuous aquifers. Contoured water-level altitudes vary across the study area and range from more than 5,000 feet in the volcanic aquifer beneath a recharge area in the northern part of the study area to less than 2,450 feet in the lower carbonate aquifer in the southern part of the study area. Variations in water-level altitudes within any single continuous aquifer range from a few hundred feet in a lower carbonate aquifer to just more than 1,100 feet in a volcanic aquifer. Flow directions throughout the study area are dominantly southward with minor eastward or westward deviations. Primary exceptions are westward flow in the northern part of the volcanic aquifer and eastward flow in the eastern part of the lower carbonate aquifer. Northward flow in the upper and lower carbonate aquifers in the northern part of the study area is possible but cannot be substantiated because data are lacking. Interflow between continuous aquifers is evaluated and mapped to define major flow paths. These flow paths delineate tributary flow systems, which converge to form the regional ground-water flow system. The implications of these tributary flow paths in controlling transport away from the underground test areas at Rainier Mesa and Shoshone Mountain are discussed. The obvious data gaps contributing to uncertainties in the delineation of aquifers and development of water-level contours are identified and evaluated.

  17. NEWE: A Western Shoshone History.

    ERIC Educational Resources Information Center

    Inter-Tribal Council of Nevada, Reno.

    One in a series of four histories of native Nevadans, this volume relates the history of the Western Shoshone, or Newe, whose territory included parts of the Great Basin area which extends from southern California to Idaho. Based on the spoken word of tribal elders and research conducted at numerous archives, the history begins with ancient…

  18. 75 FR 79018 - Notice of Realty Action: Proposed Sale of Public Lands in Bear Lake County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... Bureau of Land Management Notice of Realty Action: Proposed Sale of Public Lands in Bear Lake County, ID AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action. SUMMARY: The Bureau of Land Management (BLM) proposes the sale of 26 parcels of public lands totaling 1,543.14 acres in Bear Lake...

  19. Phase I Contaminant Transport Parameters for the Groundwater Flow and Contaminant Transport Model of Corrective Action Unit 99: Rainier Mesa/Shoshone Mountain, Nevada Test Site, Nye County, Nevada, Revision 1

    SciTech Connect

    Nathan Bryant

    2008-05-01

    This document presents a summary and framework of available transport data and other information directly relevant to the development of the Rainier Mesa/Shoshone Mountain (RMSM) Corrective Action Unit (CAU) 99 groundwater transport model. Where appropriate, data and information documented elsewhere are briefly summarized with reference to the complete documentation.

  20. Phase I Hydrologic Data for the Groundwater Flow and Contaminant Transport Model of Corrective Action Unit 99: Rainier Mesa/Shoshone Mountain, Nevada Test Site, Nye County, Nevada, Revision 1

    SciTech Connect

    Nathan Bryant

    2008-05-01

    This document presents a summary and framework of the available hydrologic data and other information directly relevant to the development of the Rainier Mesa/Shoshone Mountain (RMSM) Corrective Action Unit (CAU) 99 groundwater flow models. Where appropriate, data and information documented elsewhere are briefly summarized with reference to the complete documentation.

  1. 77 FR 47593 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) will hold a meeting on September 19...-6241 to facilitate entry into the building. FOR FURTHER INFORMATION CONTACT: Olga Troxel,...

  2. 76 FR 48877 - Kootenai National Wildlife Refuge, Boundary County, ID; Draft Comprehensive Conservation Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... Wildlife Refuge. We started this process through a notice in the Federal Register (74 FR 8102; February 23...., Sandpoint, ID 83864; and Coeur d'Alene Public Library, 702 E. Front Ave., Coeur d'Alene, ID 83814....

  3. Shoshone Spirituality Archaeological Interpretation in Southeast Idaho

    SciTech Connect

    Dean, P. A.; Marler, Clayton Fay

    2001-03-01

    Tribal people in southeast Idaho sincerely desire that archaeologists include Shoshone concepts of spirituality when investigating archaeological materials and sites. However, most archaeologists and resource managers have little understanding about these concepts and this creates difficulties. We examine two important aspects of the Shoshone soul, Mugua and Nabushiaipe, and discuss how understanding these attributes aid in explaining why certain archaeological remains are considered sacred. A greater understanding of Shoshone spirituality will begin to bridge the needs of both tribal people and archaeologists.

  4. 75 FR 10811 - Notice of Application for Recordable Disclaimer of Interest in Lands, Gem County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... Bureau of Land Management Notice of Application for Recordable Disclaimer of Interest in Lands, Gem... Rick Zamzow for a Recordable Disclaimer of Interest from the United States for islands in Gem County..., T. 6 N., R. 2 W., Boise Meridian, Gem County, Idaho, as shown on Record of Survey Instrument...

  5. Verticillium wilt in transgenic sugar beet cultivars in Cassia County, ID, 2006

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Twenty-three transgenic (resistant to glyphosate) and six commercial sugar beet cultivars were evaluated for their susceptibility to Verticillium dahliae in Heyburn, ID during the 2006 growing season. The cultivars were planted in a commercial sugar beet field and exposed to natural levels of V. da...

  6. 75 FR 57053 - Camas National Wildlife Refuge, Jefferson County, ID; Comprehensive Conservation Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ...We, the U.S. Fish and Wildlife Service (Service), intend to prepare a comprehensive conservation plan (CCP) for Camas National Wildlife Refuge (refuge) in Hamer, ID. We will also prepare an environmental assessment (EA) to evaluate the potential effects of various CCP alternatives. We are providing this notice in compliance with our CCP policy to advise the public, Federal and State agencies,......

  7. 76 FR 12753 - Notice of Temporary Closures on Public Lands in Ada and Elmore Counties, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... hereby given that the Big Fire ( FNW4) and Hot Tea Fire ( FTF6) closures to motorized vehicle use are in... this area. The Hot Tea closure affects public lands in Elmore County, Idaho, burned August 27-29, 2010, by the Hot Tea Fire, 12 miles northwest of Mountain Home, Idaho. Unburned public lands in the...

  8. Socioeconomic profiles of native American communities: Duckwater Shoshone Reservation

    SciTech Connect

    Hamby, M.

    1991-10-01

    This report presents socioeconomic aspects of Native Americans of the Duckwater Shoshone Reservation. A survey is included concerning their views on the proposed Yucca Mountain waste repository. (CBS)

  9. Socioeconomic profiles of native American communities: Yomba Shoshone Reservation

    SciTech Connect

    Hamby, M.; Rusco, E.

    1991-10-01

    This report was written by the State of Nevada Agency for Nuclear Projects/Nuclear Waste Project Office. This office oversees the nuclear waste activities for the proposed Yucca Mountain high-level waste facility for the state of Nevada. The Yomba Shoshone Reservation socio-economic profile was the basis of this paper. It describes the life and current status of the Shoshone Indians. Population, utilities, education and social services of the Shoshone are examples of the topics which are discussed. It is intended as base-line information only. It eventually summarizes and compares data from the public opinion of the Shoshone about the high level waste repository at Yucca Mountain. (MB)

  10. Cosmonaut Aleksey Leonov enjoys tribal welcome from Shoshone Indians

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Cosmonaut Aleksey A. Leonov (right), commander of the first (prime) crew of Soviet cosmonauts on the planned Apollo Soyuz Test Project (ASTP), enjoys a tribal welcome from Shoshone Indians during a hunting trip in the Lander, Wyoming area.

  11. 75 FR 70029 - Notice of Temporary Closure of Castle Rocks Inter-Agency Recreation Area in Cassia County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... Bureau of Land Management Notice of Temporary Closure of Castle Rocks Inter-Agency Recreation Area in... camping, and the construction of new trails is in effect on public lands within the Castle Rocks Inter... the BLM at Castle Rocks Inter-Agency Recreation Area in Cassia County, Idaho. Lands in the...

  12. Life Stories of Our Native People: Shoshone, Paiute, Washo.

    ERIC Educational Resources Information Center

    Inter-Tribal Council of Nevada, Reno.

    Among the native peoples who occupied the western Great Basin were a great many outstanding personalities. Various types of leaders, referred to as "headmen" or "talkers," as well as medicine men, religious leaders, and artists, played very significant roles in the history of this area. The social organization of the Western Shoshone, the Northern

  13. A Fish Consumption Survey of the Shoshone-Bannock Tribes

    EPA Science Inventory

    This report culminates two years of workpreceded by years of discussionto characterize the current and heritage fish consumption rates and fishing-related activities of the Shoshone-Bannock Tribes. The report contains three volumes in one document. Volume I is concerned with h...

  14. A Fish Consumption Survey of the Shoshone-Bannock Tribes

    EPA Science Inventory

    This report culminates two years of work—preceded by years of discussion—to characterize the current and heritage fish consumption rates and fishing-related activities of the Shoshone-Bannock Tribes. The report contains three volumes in one document. Volume I is concerned with h...

  15. 1. View looking northeast, showing from left, ID65D, ID65B and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. View looking northeast, showing from left, ID-65-D, ID-65-B and ID-65-A from the location of the former driveway. - Buffalo Guard Station, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

  16. 75 FR 28280 - Deadline for Submission of Applications To Be Included on the Roll of Western Shoshone...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    ... Shoshone Identifiable Group of Indians for Judgment Fund Distribution AGENCY: Bureau of Indian Affairs... the judgment funds awarded by the Indian Claims Commission to the Western Shoshone Identifiable Group... Indian Claims Commission to the Western Shoshone Identifiable Group of Indians in Docket No....

  17. 6. Historic American Buildings Survey William C. Everhart, Photographer October ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey William C. Everhart, Photographer October 1958 FRONT and WEST SIDE ELEVATIONS - Sacred Heart Mission, Interstate 90 & Interchange 39, Cataldo, Shoshone County, ID

  18. 5. Historic American Buildings Survey Paul J. F. Schumacher, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey Paul J. F. Schumacher, Photographer September 1957 FRONT and WEST SIDE ELEVATIONS - Sacred Heart Mission, Interstate 90 & Interchange 39, Cataldo, Shoshone County, ID

  19. 3. Historic American Buildings Survey William C. Everhart, Photographer October ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey William C. Everhart, Photographer October 1958 FRONT and EAST SIDE ELEVATIONS - Sacred Heart Mission, Interstate 90 & Interchange 39, Cataldo, Shoshone County, ID

  20. Completion Report for Well ER-12-4, Corrective Action Unit 99: Rainier Mesa - Shoshone Mountain (includes Errata Sheet)

    SciTech Connect

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Bechtel Nevada

    2006-05-01

    Well ER-12-4 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in May 2005, as part of a hydrogeologic investigation program for the Rainier Mesa-Shoshone Mountain Corrective Action Unit in the north-central portion of the Nevada Test Site. The well is located on Rainier/Aqueduct Mesa, northwest of Yucca Flat, within Area 12 of the Nevada Test Site. The well provided information regarding the radiological and physical environment near underground nuclear tests conducted in U12t Tunnel, information on the pre-Tertiary rocks in the area, and depth to the regional water table.

  1. Completion Report for Well ER-16-1 Corrective Action Unit 99: Rainier Mesa - Shoshone Mountain

    SciTech Connect

    NSTec Geology Services

    2006-12-01

    Well ER-16-1 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. The well was drilled in June and July 2005 as part of a hydrogeologic investigation program for the Rainier Mesa-Shoshone Mountain Corrective Action Unit, Number 99. The overall purpose of the well was to gather subsurface data to better characterize the hydrogeology of the Shoshone Mountain area, especially in the older Tertiary and pre-Tertiary strata. The main 46.99-centimeter hole was drilled to a depth of 702.9 meters and cased with 33.97-centimeter casing to 663.7 meters. The hole diameter was then decreased to 31.1 centimeters, and the well was drilled to total depth of 1,220.7 meters. A completion string set at the depth of 1,162.4 meters consisted of 13.97-centimeter stainless-steel casing, with one continuous slotted interval open to the lower carbonate aquifer. The fluid level in the borehole soon dropped, so the borehole was deepened in July 2006. To deepen the borehole, the slotted section was cemented and a 12.1-centimeter hole was drilled through the bottom of the completion string to the new total depth of 1,391.7 meters, which is 171.0 meters deeper than the original borehole. A string of 6.03-centimeter carbon-steel tubing with one continuous slotted interval at 1,361.8 to 1,381.4 meters, and open to the lower carbonate aquifer, was installed in the well with no gravel packing or cement, to serve as a monitoring string. Data gathered during and shortly after hole construction include composite drill cuttings samples collected every 3 meters (extra cuttings samples were collected from the Paleozoic rocks for paleontological analyses), sidewall core samples from 37 depths, various geophysical logs, and water level measurements. These data indicate that the well penetrated 646.8 meters of Tertiary volcanic rocks and 744.9 meters of Paleozoic dolomite, quartzite, shale, and limestone. Three weeks after the monitoring string was installed, the water level was tagged at the drill hole depth of 1,271.9 meters, which equates to an estimated elevation of 761.7 meters, accounting for the borehole angle.

  2. Completion Report for Well ER-12-3 Corrective Action Unit 99: Rainier Mesa - Shoshone Mountain

    SciTech Connect

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Bechtel Nevada Corporation

    2006-05-01

    Well ER-12-3 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. The well was drilled in March and April 2005 as part of a hydrogeologic investigation program for the Rainier Mesa-Shoshone Mountain Corrective Action Unit. The overall purpose of the well was to gather subsurface data to better characterize the hydrogeology of central Rainier Mesa, especially in the older Tertiary volcanic rocks and Paleozoic sedimentary rocks. The main 47.0-centimeter hole was drilled to a depth of 799.2 meters and cased with 33.97-centimeter casing to 743.1 meters. The hole diameter was then decreased to 31.1 centimeters, and the well was drilled to a total depth of 1,496.0 meters. The completion string consisted of 13.97-centimeter stainless steel casing, with two slotted intervals open to the lower carbonate aquifer, suspended from 19.37-centimeter carbon steel casing. A piezometer string was installed outside the 33.97-centimeter casing to a depth of 467.1 meters to monitor a zone of perched water within the Tertiary volcanic section. Data gathered during and shortly after hole construction include composite drill cuttings samples collected every 3 meters (extra cuttings samples were collected from the Paleozoic rocks for paleontological analyses), sidewall core samples from 35 depths, various geophysical logs, and water level measurements. These data indicate that the well penetrated 674.2 meters of Tertiary volcanic rocks and 821.7 meters of Paleozoic dolomite and limestone. Forty-nine days after the well was completed, but prior to well development and testing, the water level inside the main hole was tagged at the depth of 949.1 meters, and the water level inside the piezometer string was tagged at 379.9 meters.

  3. PROCESS WATER BUILDING, TRA605. SUMP TANK PUMP. COMPARE WITH ID33G247. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PROCESS WATER BUILDING, TRA-605. SUMP TANK PUMP. COMPARE WITH ID-33-G-247. INL NEGATIVE NO. 4378. Unknown Photographer, 3/5/1952 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  4. 78 FR 76829 - Approval of Application Submitted by Eastern Shoshone Tribe and Northern Arapaho Tribe for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...This notice announces that the EPA Regional Administrator for Region 8 has approved the December 2008 application submitted by the Northern Arapaho Tribe and Eastern Shoshone Tribe (Tribes) of the Wind River Indian Reservation for treatment in a similar manner as a state (TAS) pursuant to the Clean Air Act and the EPA's implementing regulations for purposes of certain Clean Air Act provisions.......

  5. Geophysical investigation of hot springs within the vicinity of Shoshone, California

    NASA Astrophysics Data System (ADS)

    Ziwu, F. D.; Serpa, L. F.; Doser, D. I.; Hagedorn, E. A.

    2014-12-01

    Hot springs in the Death Valley Region of California lie along the Amargosa River with distinct centers in Saratoga, Tecopa, Shoshone, and Beatty. A geophysical investigation of the hot springs in Tecopa and Saratoga led Wamalwa and other (2011) to hypothesize that deep faults must intersect with a specific orientation relative to the regional stress field in order to support hot springs along the Amargosa River. The inferred that one set of faults parallels the Amargosa River and trends northerly and the other set trends WNW to create an opening in the NW-SE oriented extensional stress field of the region. This research tests that hypothesis in the vicinity of Shoshone using magnetic and gravity data. Three isolated basalt mounds were identified in the area of the Shoshone hot springs. Two of these mounds are characterized by low magnetic and low Bouguer gravity anomalies. The third mound has high Bouguer gravity and high magnetic anomaly. This observation suggests that the basalt mounds were formed at different times and/or from different eruptive sequences. The alignment of the mounds and geophysical trends observed in the data support the earlier hypothesis and suggest there is a pair of faults trending north and west-northwest, respectively, in the area of the Shoshone hot springs. No other hot springs were located in the area but similar intersecting faults with the appropriate orientations were indicated by the geophysical data. We infer that either the basin sediments are sufficiently thick to prevent the springs from flowing to the surface or that the faults are not deep enough to tap the hot water that would produce a hot spring.

  6. ETR BASEMENT, TRA642, INTERIOR. BASEMENT. CUBICLE INTERIOR (SEE PHOTOS ID33G101 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR BASEMENT, TRA-642, INTERIOR. BASEMENT. CUBICLE INTERIOR (SEE PHOTOS ID-33-G-101 AND ID-33-G-102) WITH TANK AND SODIUM-RELATED APPARATUS. CAMERA STANDS BEFORE ROLL-UP DOOR SHOWN IN PHOTO ID-33-G-101. INL NEGATIVE NO. HD24-3-3. Mike Crane, Photographer, 11/2000 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  7. Chromosomal assignment of human ID1 and ID2 genes

    SciTech Connect

    Mathew, S.; Chen, Weiyi; Murty, V.V.V.S.; Benezra, R.; Chaganti, R.S.K.

    1995-11-20

    The Id (inhibitor of DNA binding) proteins regulate transcription during development by interacting with transcription factors. Three human genes, ID1, ID2, and ID3, have been identified that belong to this family of transcription regulators. We show, by somatic cell hybridization and fluorescence in situ hybridization experiments, that ID1 and ID2 are localized at 20q11 and 2p25, respectively. 15 refs., 2 figs.

  8. Geophysical investigation of hot springs in the vicinity of Shoshone, California

    NASA Astrophysics Data System (ADS)

    Dziedzorm, Ziwu Felix

    Magnetic and gravity surveys were conducted in the vicinity of Shoshone, California to test a hypothesis from investigating hotsprings within Tecopa and Saratoga which states that deep faults must intersect with a specific orientation relative to the regional stress field in order to create hot springs along the Amargosa River. Three isolated basalt flows with different gravity and magnetic properties were identified near the Shoshone hot spring. Two of the flows have very low magnetic anomalies and the remaining one has a high magnetic anomaly. The high magnetic anomaly basalt flow also has a significantly higher Bouguer anomaly than the other two flows associated with the low magnetic anomalies. These observations suggest that the flows were formed by different time volcanic activity with the low magnetic anomaly basalts cooling during a magnetic reversal and the high magnetic anomaly basalt cooling during normal magnetic era. The deepest part of the Tecopa basin in the study area was identified as a region with low Bouguer anomaly and associated magnetic high. These properties suggest the basin fill includes highly vesicular basalts which would give the low density. Generally regions of high magnetic anomalies also have high Bouguer anomalies which indicate the possible existence of igneous rocks in the region. The low magnetic anomalies are mainly seen in the regions of thicker sedimentary deposits such as in the Resting Springs range where Precambrian and Paleozoic sedimentary rocks are preserved. From the magnetic and gravity surveys, this research support the testing hypothesis based on the identified intersecting faults of the appropriate orientation associated with the Shoshone hot spring. Faults were also identified at places with no evidence of hot springs and this could be due to the presence of thicker sediments preventing the springs from flowing to the surface. An alternative possibility is that the faults are not deep enough to tap the hot water that would produce a hot spring.

  9. Magnetotelluric Data, Rainier Mesa/Shoshone Mountain, Nevada Test Site, Nevada.

    SciTech Connect

    Jackie M. Williams; Jay A. Sampson; Brian D. Rodriguez; and Theodore H. Asch.

    2006-11-03

    The United States Department of Energy (DOE) and the National Nuclear Security Administration (NNSA) at their Nevada Site Office (NSO) are addressing ground-water contamination resulting from historical underground nuclear testing through the Environmental Management (EM) program and, in particular, the Underground Test Area (UGTA) project. From 1951 to 1992, 828 underground nuclear tests were conducted at the Nevada Test Site northwest of Las Vegas. Most of these tests were conducted hundreds of feet above the ground-water table; however, more than 200 of the tests were near or within the water table. This underground testing was limited to specific areas of the Nevada Test Site, including Pahute Mesa, Rainier Mesa/Shoshone Mountain, Frenchman Flat, and Yucca Flat. One issue of concern is the nature of the somewhat poorly constrained pre-Tertiary geology, and its effects on ground-water flow. Ground-water modelers would like to know more about the hydrostratigraphy and geologic structure to support a hydrostratigraphic framework model that is under development for the Rainier Mesa/Shoshone Mountain Corrective Action Unit (Bechtel Nevada, 2006). During 2005, the U.S. Geological Survey (USGS), in cooperation with the DOE and NNSA-NSO, collected and processed data from twenty-six magnetotelluric (MT) and audio-magnetotelluric (AMT) sites at the Nevada Test Site. The 2005 data stations were located on and near Rainier Mesa and Shoshone Mountain to assist in characterizing the pre-Tertiary geology in those areas. These new stations extend the area of the hydrogeologic study previously conducted in Yucca Flat. This work will help refine what is known about the character, thickness, and lateral extent of pre-Tertiary confining units. In particular, a major goal has been to define the upper clastic confining unit (UCCU – late Devonian to Mississippian-age siliciclastic rocks assigned to the Eleana Formation and Chainman Shale) from the Yucca Flat area and west towards Shoshone Mountain, to Buckboard Mesa in the south, and onto Rainier Mesa in the north. Subsequent interpretation will include a three-dimensional (3-D) character analysis and a two-dimensional (2-D) resistivity model. The purpose of this report is to release the MT sounding data for the twenty-six stations shown in figure 1. No interpretation of the data is included here.

  10. 76 FR 54482 - Notice of Intent To Prepare an Environmental Impact Statement for the Shoshone Basin Grazing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... Bureau of Land Management Notice of Intent To Prepare an Environmental Impact Statement for the Shoshone.... SUMMARY: In compliance with the National Environmental Policy Act of 1969, as amended, and the Federal... Office, Burley, Idaho intends to prepare an environmental impact statement (EIS) and by this notice...

  11. 2. Left side of Zinc Plant, from packless Cooling Tower ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Left side of Zinc Plant, from packless Cooling Tower to midpoint of Cell Room, with majority of Upper Plant in view. View is to the east. - Sullivan Electrolytic Zinc Plant, Government Gulch, Kellogg, Shoshone County, ID

  12. 3. Right side of Zinc Plant, from Cell Room midpoint ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Right side of Zinc Plant, from Cell Room midpoint to Plant Office (foreground) and #5 Roaster and Concentrate Handling (background). View is to the east. - Sullivan Electrolytic Zinc Plant, Government Gulch, Kellogg, Shoshone County, ID

  13. AFRD WAREHOUSE, INTERIOR DETAIL OF RAFTER SUPPORT POST TIMBER AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AFRD WAREHOUSE, INTERIOR DETAIL OF RAFTER SUPPORT POST TIMBER AND METHOD OF BRACING. THE BRACES PENETRATE THE SHEET ROCK, SUGGESTING THAT THESE ARE ORIGINAL. - Minidoka Relocation Center Warehouse, 111 South Fir Street, Shoshone, Lincoln County, ID

  14. AFRD WAREHOUSE, SOUTH SIDE. FACING NORTH. METAL AWNING ALONG LENGTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AFRD WAREHOUSE, SOUTH SIDE. FACING NORTH. METAL AWNING ALONG LENGTH OF BUILDING AND VERTICAL METAL SIDING ARE ALTERATIONS MAD BY THE AFRD. - Minidoka Relocation Center Warehouse, 111 South Fir Street, Shoshone, Lincoln County, ID

  15. AFRD WAREHOUSE, INTERIOR, FACING SOUTHEAST TOWARD SOUTHEAST CORNER. SHEET ROCK ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AFRD WAREHOUSE, INTERIOR, FACING SOUTHEAST TOWARD SOUTHEAST CORNER. SHEET ROCK ON CEILING. RAFTERS ARE SUPPORTED BY POST. - Minidoka Relocation Center Warehouse, 111 South Fir Street, Shoshone, Lincoln County, ID

  16. AFRD WAREHOUSE, SOUTH SIDE DETAIL, SLIDING DOORS. FACING NORTH. COMPARE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AFRD WAREHOUSE, SOUTH SIDE DETAIL, SLIDING DOORS. FACING NORTH. COMPARE WITH FIGURES 4 AND 5 IN NARRATIVE REPORT, WHICH SHOW DIAGONAL BRACES BELOW GLAZED SECTION OF DOORS. - Minidoka Relocation Center Warehouse, 111 South Fir Street, Shoshone, Lincoln County, ID

  17. 10. UNDERSIDE OF BRIDGE SHOWING SUPERSTRUCTURE, TOWERS, CONCRETE FOOTINGS, AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. UNDERSIDE OF BRIDGE SHOWING SUPERSTRUCTURE, TOWERS, CONCRETE FOOTINGS, AND ROCK ABUTMENT OF ORIGINAL CROSSING (PRE 1920), FACING SOUTHWEST - Rock Creek Bridge, Shoshone Street West spanning Rock Creek, Twin Falls, Twin Falls County, ID

  18. 9. Historic American Buildings Survey John N. DeHaas, Jr., Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey John N. DeHaas, Jr., Photographer August 1963 VIEW OF HAND CARVED CEILING PANEL - Sacred Heart Mission, Interstate 90 & Interchange 39, Cataldo, Shoshone County, ID

  19. 8. Historic American Buildings Survey John N. DeHaas, Jr., Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey John N. DeHaas, Jr., Photographer August 1963 EAST ELEVATION (Looking Northward) - Sacred Heart Mission, Interstate 90 & Interchange 39, Cataldo, Shoshone County, ID

  20. 2. Historic American Buildings Survey William C. Everhart, Photographer October ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey William C. Everhart, Photographer October 1958 VIEW FROM THE NORTHEAST (Residence of Caretaker at Left) - Sacred Heart Mission, Interstate 90 & Interchange 39, Cataldo, Shoshone County, ID

  1. 13. Historic American Buildings Survey John N. DeHaas, Jr., Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Historic American Buildings Survey John N. DeHaas, Jr., Photographer August 1963 COLUMN DETAILS AT APSE AND SIDE ALTAR - Sacred Heart Mission, Interstate 90 & Interchange 39, Cataldo, Shoshone County, ID

  2. 10. Historic American Buildings Survey John N. DeHaas, Jr., Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey John N. DeHaas, Jr., Photographer August 1963 VIEW OF HAND CARVED CEILING PANEL - Sacred Heart Mission, Interstate 90 & Interchange 39, Cataldo, Shoshone County, ID

  3. 1. Zinc Plant, looking north, down Government Gulch. 610 ft. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Zinc Plant, looking north, down Government Gulch. 610 ft. tall stack replaced original 200 ft. radial brick stack formerly at rear of Cottrell treater. - Sullivan Electrolytic Zinc Plant, Government Gulch, Kellogg, Shoshone County, ID

  4. 4. Anode Building. View is to the east. This facility, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Anode Building. View is to the east. This facility, which was used for the cleaning and manufacture of anodes, was documented prior to demolition in 1993. - Sullivan Electrolytic Zinc Plant, Government Gulch, Kellogg, Shoshone County, ID

  5. Deep Resistivity Structure of Rainier Mesa-Shoshone Mountain, Nevada Test Site, Nevada

    SciTech Connect

    Theodore H. Asch; Brian D. Rodriguez; Jay A. Sampson; Jackie M. Williams; Maryla Deszcz-Pan

    2006-12-12

    The U. S. Department of Energy (DOE) and the National Nuclear Security Administration (NNSA) at their Nevada Site Office (NSO) are addressing groundwater contamination resulting from historical underground nuclear testing through the Environmental Management (EM) program and, in particular, the Underground Test Area (UGTA) project. During 2005, the U.S. Geological Survey (USGS), funded by the DOE and NNSA-NSO, collected and processed data from twenty-six Magnetotelluric (MT) and Audio-Magnetotelluric (AMT) sites at the Nevada Test Site. Data stations were located in and near Rainier Mesa and Shoshone Mountain to assist in characterizing the pre-Tertiary geology in those areas. These new stations extend to the west the hydrogeologic study that was conducted in Yucca Flat in 2003. This work has helped to refine the character, thickness, and lateral extent of pre Tertiary confining units. In particular, a major goal has been to define the upper clastic confining unit (UCCU – late Devonian to Mississippian-age siliciclastic rocks assigned to the Eleana Formation and Chainman Shale(Bechtel Nevada, 2006)) in the Yucca Flat area and west towards Shoshone Mountain in the south, east of Buckboard Mesa, and onto Rainier Mesa in the north. The Nevada Test Site magnetotelluric data interpretation presented in this report includes the results of detailed two-dimensional (2 D) resistivity modeling for each profile (including alternative interpretations) and gross inferences on the three dimensional (3 D) character of the geology within the region. The character, thickness, and lateral extent of the Chainman Shale and Eleana Formation that comprise the Upper Clastic Confining Unit (UCCU) are generally characterized in the upper 5 km. The interpretation is not well determined where conductive TCU overlies conductive Chainman Shale, where resistive Eleana Formation overlies resistive LCA units, or where resistive VTA rock overlies units of the Eleana Formation. The nature of the volcanic units in the west has been refined as are large and small fault structures such as the CP Thrust Fault, the Carpetbag Fault, and the Yucca Fault that cross Yucca Flat. The subsurface electrical resistivity distribution and inferred geologic structures determined by this investigation should help constrain the hydrostratigraphic framework model that is under development for the Rainier Mesa/Shoshone Mountain Corrective Action Unit and areas to the west and in understanding the effects on ground-water flow in the area.

  6. Tribal Wind Assessment by the Eastern Shoshone Tribe of the Wind River Reservation

    SciTech Connect

    Pete, Belvin; Perry, Jeremy W.; Stump, Raphaella Q.

    2009-08-28

    The Tribes, through its consultant and advisor, Distributed Generation Systems (Disgen) -Native American Program and Resources Division, of Lakewood CO, assessed and qualified, from a resource and economic perspective, a wind energy generation facility on tribal lands. The goal of this feasibility project is to provide wind monitoring and to engage in preproject planning activities designed to provide a preliminary evaluation of the technical, economic, social and environmental feasibility of developing a sustainable, integrated wind energy plan for the Eastern Shoshone and the Northern Arapahoe Tribes, who resides on the Wind River Indian Reservation. The specific deliverables of the feasibility study are: 1) Assessments of the wind resources on the Wind River Indian Reservation 2) Assessments of the potential environmental impacts of renewable development 3) Assessments of the transmission capacity and capability of a renewable energy project 4) Established an economic models for tribal considerations 5) Define economic, cultural and societal impacts on the Tribe

  7. Simple estimation of minimum unsaturated contaminant travel times at Rainier Mesa and Shoshone Mountain, Nevada Test Site

    NASA Astrophysics Data System (ADS)

    Ebel, B. A.; Nimmo, J. R.

    2008-12-01

    In the unsaturated zone the fastest travel times frequently occur via preferential flow that bypasses the soil/rock matrix. Experimental data provide compelling evidence that minimum solute travel times through preferential paths depend primarily on whether water supply is continuous versus non-continuous in time, with little influence from matrix hydraulic properties. We employ a simple model based on this "source- responsive" paradigm to estimate minimum preferential travel times to the regional water table for nonreactive radionuclides at Rainier Mesa and Shoshone Mountain within the Nevada Test Site. The radionuclides at the site originate from underground nuclear testing within a ~1-km-thick unsaturated zone. Contaminated sources at Rainier Mesa and Shoshone Mountain that are continuously supplied include ponded water in certain tunnels, filled detention basins, and partially-filled boreholes with detonation cavities. Tunnels without ponding and unfilled detonation cavities are considered non-continuous sources supplied by percolation of precipitation. Decades of geological and hydrological characterizations provide the foundation for establishing preferential flow as a viable transport mechanism at Rainier Mesa and Shoshone Mountain Our estimated minimum travel times via preferential flow for Rainier Mesa are one to two months for a continuously-supplied source and tens to hundreds of years for a non-continuous source. Previous studies in the scientific literature conducted isotopic analysis of fracture water collected in tunnels at Rainier Mesa that indicated transit times for 400 m of transport from land surface to tunnel levels of one to 40 years. Four monitoring wells in the carbonate aquifer have not detected radionuclide levels above the drinking water standards at Rainier Mesa. Travel times for both the continuously and non-continuously supplied sources at Shoshone Mountain are twice the Rainier Mesa estimates, resulting from longer transport distances and less precipitation. A shale confining unit at Shoshone Mountain may cause a transition from preferential to matrix dominated flow, increasing estimated transport times to more than a thousand years. Concentrations of radionuclides above the drinking water standard have not been detected in a deep well or in springs at Shoshone Mountain. Preliminary results from our analysis indicate the potentially rapid nature of unsaturated-zone preferential transport (despite a semi-arid climate) for continuous sources and highlight the value of a simple modeling approach to complement traditional, more complex flow simulation approaches for contaminant travel time estimation.

  8. 139. MILNER DAM, TWIN FALLS COUNTY, MILNER, IDAHO; OUTLET SIDE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    139. MILNER DAM, TWIN FALLS COUNTY, MILNER, IDAHO; OUTLET SIDE OF SPILLWAY, EAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  9. 125. COTTONWOOD CUT AREA, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    125. COTTONWOOD CUT AREA, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; SOUTH VIEW OF CANAL. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  10. 107. MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    107. MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; WEST VIEW OF LAKE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  11. 108. MURTAUGH LAKE HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    108. MURTAUGH LAKE HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; OVERALL VIEW SOUTH. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  12. 127. COTTONWOOD CUT AREA, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    127. COTTONWOOD CUT AREA, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; NORTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  13. 128. COTTONWOOD CUT, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    128. COTTONWOOD CUT, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; NORTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  14. 100. MURTAUGH LAKE HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    100. MURTAUGH LAKE HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; SOUTH VIEW OF HEADGATES. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  15. 39. CALCINER CELL PLANS. TOGETHER WITH HAER ID33C37 ILLUSTRATES COMPLEXITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. CALCINER CELL PLANS. TOGETHER WITH HAER ID-33-C-37 ILLUSTRATES COMPLEXITY OF PIPING. INEEL DRAWING NUMBER 200-0633-00-287-106445. FLUOR NUMBER 5775-CPP-633-P-50 - Idaho National Engineering Laboratory, Old Waste Calcining Facility, Scoville, Butte County, ID

  16. 40. CALCINER CELL SECTIONS. TOGETHER WITH HAER ID33C37 ILLUSTRATES COMPLEXITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    40. CALCINER CELL SECTIONS. TOGETHER WITH HAER ID-33-C-37 ILLUSTRATES COMPLEXITY OF PIPING. INEEL DRAWING NUMBER 200-0633-00-287-106446. FLUOR NUMBER 5775-CPP-P-51. - Idaho National Engineering Laboratory, Old Waste Calcining Facility, Scoville, Butte County, ID

  17. 13. TIP TOP MINE. WOODEN STRUCTURE VISIBLE IN ID31C12 ISIN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. TIP TOP MINE. WOODEN STRUCTURE VISIBLE IN ID-31-C-12 ISIN UPPER LEFT. ALSO VISIBLE ARE TWO VERTICALLY BURIED LOGS ASSOCIATED WITH CABLES, ONE OF WHICH IS VISIBLE IN LOWER RIGHT. CAMERA POINTED SOUTH. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

  18. Successful I.D. Encounters.

    ERIC Educational Resources Information Center

    Poorman, Margaret J.

    Instructional Development (I.D.) encounters are dependent for success on such variables as power, politics, promotion, and organizational placement. I.D. consultants must be aware of power bases or orientation of other personnel and clients, e.g., these four "power personalities" which affect their efforts in managing I.D. encounters: the gate

  19. Simple estimation of fastest preferential contaminant travel times in the unsaturated zone: application to Rainier Mesa and Shoshone Mountain, Nevada

    NASA Astrophysics Data System (ADS)

    Ebel, B. A.; Nimmo, J. R.

    2010-06-01

    Simulating contaminant transport in unsaturated zones with sparse hydraulic property information is a difficult, yet common, problem. When contaminant transport may occur via preferential flow, simple modeling approaches can provide predictions of interest, such as the first arrival of contaminant, with minimal site characterization. The conceptual model for unsaturated zone flow at two areas within the Nevada Test Site, Rainier Mesa and Shoshone Mountain, establishes the possibility of preferential flow through lithologies between potential radionuclide sources and the saturated zone. Lithology, saturated or near-saturated conditions in portions of the rock matrix, and relatively high recharge rates may act in concert at Rainier Mesa to promote preferential flow, despite the semi-arid climate. After identifying preferential flow as a possible contaminant transport process at Rainier Mesa and Shoshone Mountain, we apply a simple model to estimate fastest unsaturated travel times for conservatively-transported radionuclides to initially reach the saturated zone. Preferential flow travel times at Rainier Mesa are tens to hundreds of years for non-ponded water sources and one to two months for continuously-ponded water sources. If preferential flow occurs at Shoshone Mountain, the fastest travel times are approximately twice the Rainier Mesa estimates. A siliceous rock unit is present at Shoshone Mountain that may provide a barrier to preferential flow; if so, estimated transport times increase to more than a thousand years. Our analysis of unsaturated transport of radionuclides via preferential flow, using a relatively simple model, suggests that contaminated locations associated with continuously-supplied water sources, such as effluent ponds and water-filled tunnels, may have significantly shorter radionuclide travel times than locations not associated with such sources. The simple approach demonstrated here for estimating travel times can be useful in situations where predictions are needed by managers for the fastest arrival of contaminants, yet budgetary or time constraints preclude more rigorous analysis, and when additional model estimates are needed for comparison (i.e. model abstraction).

  20. IDS transfer from overexpressing cells to IDS-deficient cells.

    PubMed

    Millat, G; Froissart, R; Maire, I; Bozon, D

    1997-02-01

    Iduronate sulfatase (IDS) is responsible for mucopolysaccharidosis type II, a rare recessive X-linked lysosomal storage disease. The aim of this work was to test the ability of overexpressing cells to transfer IDS to deficient cells. In the first part of our work, IDS processing steps were compared in fibroblasts, COS cells, and lymphoblastoid cell lines and shown to be identical: the two precursor forms (76 and 90 kDa) were processed by a series of intermediate forms to the 55- and 45-kDa mature polypeptides. Then IDS transfer to IDS-deficient cells was tested either by incubation with cell-free medium of overexpressing cells or by coculture. Endocytosis and coculture experiments between transfected L beta and deleted fibroblasts showed that IDS transfer occurred preferentially by cell-to-cell contact as IDS precursors are poorly secreted by transfected L beta. The 76- and 62-kDa IDS polypeptides transferred to deleted fibroblasts were correctly processed to the mature 55- and 45-kDa forms. L beta were not able to internalize the 90-kDa phosphorylated precursor forms excreted in large amounts in the medium of overexpressing fibroblasts. Enzyme transfer occurred only by cell-to-cell contact, but the precursor forms transferred in L beta after cell-to-cell contact were not processed. This absence of maturation was probably due to a mistargeting of IDS precursors in these cells. PMID:9024795

  1. Magnetotelluric Data, Rainier Mesa/Shoshone Mountain, Nevada Test Site, Nevada

    USGS Publications Warehouse

    Williams, Jackie M.; Sampson, Jay A.; Rodriguez, Brian D.; Asch, Theodore H.

    2006-01-01

    Introduction: The United States Department of Energy (DOE) and the National Nuclear Security Administration (NNSA) at their Nevada Site Office (NSO) are addressing ground-water contamination resulting from historical underground nuclear testing through the Environmental Management (EM) program and, in particular, the Underground Test Area (UGTA) project. During 2005, the U.S. Geological Survey (USGS), in cooperation with the DOE and NNSA-NSO, collected and processed data from twenty-six magnetotelluric (MT) and audio-magnetotelluric (AMT) sites at the Nevada Test Site. The 2005 data stations were located on and near Rainier Mesa and Shoshone Mountain to assist in characterizing the pre-Tertiary geology in those areas. These new stations extend the area of the hydrogeologic study previously conducted in Yucca Flat. The MT data presented in this report will help refine what is known about the character, thickness, and lateral extent of pre Tertiary confining units. Subsequent interpretation will include a three dimensional (3 D) character analysis and a two-dimensional (2 D) resistivity model. The purpose of this report is to release the MT sounding data. No interpretation of the data is included here.

  2. Facts about Infectious Diseases (ID)

    MedlinePLUS

    ... Quality Improvement Value of ID Specialists Trends in Health Care Technology and Telehealth Medicare & Your Practice Practice Management Listserve Guidelines/Patient Care IDSA Practice Guidelines Guideline ...

  3. DHSIsotopeID

    Energy Science and Technology Software Center (ESTSC)

    2007-12-18

    DHSIsotopeID is an application designed to read and analyze radiation measurement files taken by radiation measurement files taken by radiation portal monitors, and in particular, by the advanced spectroscopic portals. It requires that the data files be in the N42 file format, compliant with the interface control documents for DNDO radiation measurement files. It carries out an automated analysis to determine which isotopes are present in the spectra, and then presents the results in graphicalmore » form to the user. It also enables further post-processing and analysis, for example by performing further analysis on selected regions of interest of the spectrum, as designated by the user via the graphical interface.« less

  4. Corporate ID/PT Standards.

    ERIC Educational Resources Information Center

    Silber, Kenneth H.

    1992-01-01

    This report outlines corporate instructional design and performance technology (ID/PT) standards, including what they are; how they help an organization; advantages and disadvantages of having standards; types of standards (focus, approach, and scope); content; and formats. A worksheet for determining ID/PT standards is included. (DB)

  5. Corrective Action Investigation Plan for Corrective Action Unit 99: Rainier Mesa/Shoshone Mountain, Nevada Test Site, Nevada with Errata and ROTC 1, Rev. No. 0

    SciTech Connect

    John McCord; Marutzky, Sam

    2004-12-01

    This Corrective Action Investigation Plan (CAIP) was developed for Corrective Action Unit (CAU) 99, Rainier Mesa/Shoshone Mountain. The CAIP is a requirement of the ''Federal Facility Agreement and Consent Order'' (FFACO) agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense (DoD) (FFACO, 1996). The FFACO addresses environmental restoration activities at U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) facilities and sites including the underground testing area(s) of the Nevada Test Site (NTS). This CAIP describes the investigation activities currently planned for the Rainier Mesa/Shoshone Mountain CAU. These activities are consistent with the current Underground Test Area (UGTA) Project strategy described in Section 3.0 of Appendix VI, Revision No. 1 (December 7, 2000) of the FFACO (1996) and summarized in Section 2.1.2 of this plan. The Rainier Mesa/Shoshone Mountain CAU extends over several areas of the NTS (Figure 1-1) and includes former underground nuclear testing locations in Areas 12 and 16. The area referred to as ''Rainier Mesa'' includes the geographical area of Rainier Mesa proper and the contiguous Aqueduct Mesa. Figure 1-2 shows the locations of the tests (within tunnel complexes) conducted at Rainier Mesa. Shoshone Mountain is located approximately 20 kilometers (km) south of Rainier Mesa, but is included within the same CAU due to similarities in their geologic setting and in the nature and types of nuclear tests conducted. Figure 1-3 shows the locations of the tests conducted at Shoshone Mountain. The Rainier Mesa/Shoshone Mountain CAU falls within the larger-scale Rainier Mesa/Shoshone Mountain Investigation Area, which also includes the northwest section of the Yucca Flat CAU as shown in Figure 1-1. Rainier Mesa and Shoshone Mountain lie adjacent to the Timber Mountain Caldera Complex and are composed of volcanic rocks that erupted from the caldera as well as from more distant sources. This has resulted in a layered volcanic stratigraphy composed of thick deposits of welded and nonwelded ash-flow tuff and lava flows. These deposits are proximal to the source caldera and are interstratified with the more distal facies of fallout tephra and bedded reworked tuff from more distant sources. In each area, a similar volcanic sequence was deposited upon Paleozoic carbonate and siliciclastic rocks that are disrupted by various thrust faults, normal faults, and strike-slip faults. In both Rainier Mesa (km) to the southwest, and Tippipah Spring, 4 km to the north, and the tunnel complex is dry. Particle-tracking simulations performed during the value of information analysis (VOIA) (SNJV, 2004b) indicate that most of the regional groundwater that underlies the test locations at Rainier Mesa and Shoshone Mountain eventually follows similar and parallel paths and ultimately discharges in Death Valley and the Amargosa Desert. Particle-tracking simulations conducted for the regional groundwater flow and risk assessment indicated that contamination from Rainier Mesa and Shoshone Mountain were unlikely to leave the NTS during the 1,000-year period of interest (DOE/NV, 1997a). It is anticipated that CAU-scale modeling will modify these results somewhat, but it is not expected to radically alter the outcome of these previous particle-tracking simulations within the 1,000-year period of interest. The Rainier Mesa/Shoshone Mountain CAIP describes the corrective action investigation (CAI) to be conducted at the Rainier Mesa/Shoshone Mountain CAU to evaluate the extent of contamination in groundwater due to the underground nuclear testing. The CAI will be conducted by the UGTA Project, which is part of the NNSA/NSO Environmental Restoration Project (ERP). The purpose and scope of the CAI are presented in this section, followed by a summary of the entire document.

  6. IDS contribution to ITRF2008

    NASA Astrophysics Data System (ADS)

    Valette, J.; Lemoine, F.; Ferrage, P.; Altamimi, Z.; Willis, P.; Stepanek, P.; Otten, M.; Govind, R.; Kuzin, S.; Le Bail, K.; Moore, P.; Yaya, P.; Soudarin, L.

    2009-12-01

    The International DORIS Service (IDS), in operation since 2003, submitted three sets of solutions to ITRF2005 from the IGN/JPL, LEGOS/CLS, and INASAN analysis centers, but no DORIS technique combination. Since that time new analysis centers have become operational including the Geodetic Observatory Pecny (GOP), the European Space Operations Center (ESOC), Geoscience Australia (GAU), the NASA Goddard Space Flight Center (GSC), and the University of Newcastle (NCL). These analysis centers run different software, including Gypsy (IGN & INASAN), GINS (LCA), Bernese (GOP), NAPEOS (ESOC), GEODYN (Geoscience Australia and NASA GSFC) and FAUST (NCL). In order to contribute to ITRF2008, seven analysis centers processed DORIS data from TOPEX/Poseidon, SPOT2, SPOT3, SPOT4, SPOT5, and ENVISAT from 1992 to 2008, producing weekly SINEX solutions or normal equations. The weekly SINEX files from seven ACs were processed with the CATREF software. Three iterations of an IDS weekly combined time series were completed. The IDS-1, and IDS-2 combinations were preliminary station-only solutions. In the final combination, IDS-3, both stations and the Earth Orientation Paramters (EOPs) were adjusted. Between each of the IDS combinations, the combination strategy (station filtering, outliers, weighting, scale or geocenter contributions) was improved and the ACs SINEX series were refined. Some series were extended in data span while others were recomputed to correct anomalies or to improve the quality of the submissions, based on feedback from the combination analyses and intercenter comparisons. For example in IDS-1, both the GAU and GSC solutions were affected by a 20 mm scale offset that was removed in IDS-2 and IDS-3 after the application of improved troposphere modelling in the GEODYN software. The analysis for IDS-1 showed a higher station position WRMS in the vicinity of the high solar flux periods (late 2001-2002). Consequently for IDS-2, several ACs (LCA, GAU, GSC) recomputed their orbits to estimate drag coefficients more frequently to mitigate this effect. The analysis of the frequency and amplitude of geocenter and scale signals was used to define the AC contributions to geocenter and scale in the final combination IDS-3. The comparisons of IDS-3 w.r.t. ITRF2008 are presented. Future prospects and plans for the IDS DORIS analyses are discussed.

  7. Coupled variations in helium isotopes and fluid chemistry: Shoshone Geyser Basin, Yellowstone National Park

    USGS Publications Warehouse

    Hearn, E.H.; Kennedy, B.M.; Truesdell, A.H.

    1990-01-01

    Early studies of 3He/4He variations in geothermal systems have generally attributed these fluctuations to either differences in the source of the magmatic 3He-rich helium or to local differences in the deep flux of magmatic 3He-rich helium. Kennedy et al. (1987), however, show that near-surface processes such as boiling and dilution may also drastically affect 3He 4He ratios of geothermal vapors. Helium isotope ratios were determined for several hot springs at Shoshone Geyser Basin of Yellowstone National Park for this study, along with other noble gas data. Stable isotope data and water and gas chemistry data for each spring were also compiled. The water chemistry indicates that there is one deep, hot thermal water in the area which is mixing with dilute meteoric water that has entered the system at depth. Spring HCO3- concentrations correlate with 3He 4He values, as in nearby Lower Geyser Basin. This correlation is attributed to variable amounts of deep dilution of thermal waters with a relatively cool water that inhibits boiling at depth, thus preventing the loss of CO2 (and therefore HCO3-) and magmatic He in the most diluted samples. Oxygen and hydrogen isotope data also support a boiling and dilution model, but to produce the observed fractionations, the boiling event would have to be extensive, with steam loss at the surface, whereas the boiling that affected the helium isotope ratios was probably a small scale event with steam loss at depth. It is possible that deep boiling occurred in the basin and that small amounts of steam escaped along fractures at about 500 m below the surface while all subsequently produced steam was lost near or at the surface. ?? 1990.

  8. Coupled variations in helium isotopes and fluid chemistry: Shoshone Geyser Basin, Yellowstone National Park

    SciTech Connect

    Hearn, E.H.; Kennedy, B.M. ); Truesdell, A.H. )

    1990-11-01

    Early studies of {sup 3}He/{sup 4}He variations in geothermal systems have generally attributed these fluctuations to either differences in the source of the magmatic {sup 3}He-rich helium or to local differences in the deep flux of magmatic {sup 3}He-rich helium. Kennedy et al, however, show that near-surface processes such as boiling and dilution may also drastically affect {sup 3}He/{sup 4}He ratios of geothermal vapors. Helium isotope ratios were determined for several hot springs at Shoshone Geyser Basin of Yellowstone National Park for this study, along with other noble gas data. Stable isotope data and water and gas chemistry data for each spring were also compiled. The water chemistry indicates that there is one deep, hot thermal water in the area which is mixing with dilute meteoric water that has entered the system at depth. Spring HCO{sub 3}{sup {minus}} concentrations correlate with {sup 3}He/{sup 4}He values, as in nearby Lower Geyser Basin. This correlation is attributed to variable amounts of deep dilution of thermal waters with a relatively cool water that inhibits boiling at depth, thus preventing the loss of CO{sub 2} and magmatic He in the most diluted samples. Oxygen and hydrogen isotope data also support a boiling and dilution model, but to produce the observed fractionations, the boiling event would have to be extensive, with steam loss at the surface, whereas the boiling that affected the helium isotope ratios was probably a small scale event with steam loss at depth. It is possible that deep boiling occurred in the basin and that small amounts of steam escaped along fractures at about 500 m below the surface while all subsequently produced steam was lost near or at the surface.

  9. Superfund record of decision (EPA Region 10): Mountain Home Air Force Base, Site 8, Fire Training Area 8, Operable Unit 4, Elmore County, Mountain Home, ID. (First remedial action), June 1992. Final report

    SciTech Connect

    Not Available

    1992-06-16

    The 7-acre Mountain Home Air Force Base (AFB) site was a fire department training area located in Mountain Home, Elmore County, Idaho. From 1962 to 1975, the Mountain Home Air Force Base used the site for fire department training exercises. Each exercise began by saturating the bermed training area with water, followed directly by applying 250 to 500 gallons of fuel. The flames were extinguished with Aqueous Film Forming Foam (AFFF), or prior to 1972, with a water-based protein foam. The training session was completed with a post-exercise ignition of the residual fuel in a bermed area. The USAF investigations identified solvents and petroleum, oil, lubricant (POL) wastes in the soil. Under the Installation Restoration Program (IRP), the USAF conducted a record search, drilling, and sampling of soil borings to bedrock, the installation of monitoring wells, and hand auger samples. The ROD provided a final remedy for onsite soil as OU4. Because contaminants were found at such low concentrations, the soil was covered by crushed asphalt and has little potential to impact ecological receptors. The soil posed low risks for humans at the site and no remediation was necessary.

  10. ETR BUILDING, TRA642, INTERIOR. BASEMENT. CUBICLE SHOWN IN ID33G101, ANOTHER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR BUILDING, TRA-642, INTERIOR. BASEMENT. CUBICLE SHOWN IN ID-33-G-101, ANOTHER VIEW. PERSONNEL DOORWAY INTO CHAMBER IDENTIFIES SODIUM HAZARD AND POSSIBILITY OF INERT GAS. LIQUID SODIUM COOLANT WAS USED IN A SPECIAL ETR LOOP ADAPTED FOR IT IN 1972. INL NEGATIVE NO. HD24-3-2. Mike Crane, Photographer, 11/2000 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  11. Low-angle slumps in lacustrine environments: the Shoshone (Tecopa basin, California) example

    NASA Astrophysics Data System (ADS)

    Alfaro, Pedro; Gibert, Luis; García Tortosa, Francisco J.; Owen, Geraint; Moretti, Massimo; Scott, Gary

    2015-04-01

    In lacustrine environments, the presence of seismically-induced slump sheets on gentle slopes seems to be very widespread (Alsop and Marco, 2013; García-Tortosa et al., 2011; Gibert et al., 2005). A low-angle slump is extraordinarily well exposed in middle Pleistocene lacustrine deposits of the Tecopa Basin (California, United States), next to the village of Shoshone. Good lateral continuity of stratigraphical sections allowed a detailed description of the slump sheet and a reliable interpretation taking into account main morphological features, data coming from the facies analysis of the involved beds and on the regional tectonic activity. The slump sheet, ~ 2 m thick, is constituted by four units with different rheological characteristics. This heterogeneous composition is the key controlling factor which produces a large variety of soft-sediment deformational structures of different scale (folds, thrusts, breccias, fluidization structures). An earthquake related to regional faults might cause liquefaction and fluidization, and the initiation of the gravitational movement. When slump translation ceases, at the toe of the slump, then contractional strain propagates upslope and internal deformation occurs in the slump sheet. The top bed of the slump sheet, ~1 m of sands, developed decametric-scale folds while underlying sediments migrates laterally from the synform hinges to the core of the anticlines. Different velocity gradients in the downslope direction generate several superposed layer-parallel shear with two main detachments and many secondary internal ones. This new example in the Tecopa Basin, confirms that slumps are a good record of seismicity in low-angle sedimentary environments. Alsop, G.I. & Marco, S. (2013): Seismogenic slump folds formed by gravity-driven tectonics down a negligible subaqueous slope. Tectonophysics, 605: 48-69. García-Tortosa, F.J., Alfaro, P., Gibert, L. & Scott, G (2011): Seismically induced slump on an extremely gentle slope (<1°) of the Pleistocene Tecopa paleolake (California). Geology, 39: 1055-1058. doi:10.1130/G32218.1 Gibert, L., Sanz de Galdeano, C., Alfaro, P., Scott, G. & López Garrido, A.C. (2005): Seismic-induced slump in Early Pleistocene deltaic deposits of the Baza Basin (SE Spain). Sedimentary Geology, 179: 279-294. doi:10.1016/j.sedgeo.2005.06.003.

  12. ISS/IDS Detector Study

    SciTech Connect

    Cervera-Villanueva, A.

    2008-02-21

    This article summarises the results obtained by the detector working group of the 'International Scooping Study' (ISS) of a future neutrino oscillations facility. Special emphasis is put on far detectors, for which some of the main issues are identified. A detector R and D strategy in the context of the 'International Design Study' (IDS) for a neutrino factory is also presented.

  13. Threshold extended ID3 algorithm

    NASA Astrophysics Data System (ADS)

    Kumar, A. B. Rajesh; Ramesh, C. Phani; Madhusudhan, E.; Padmavathamma, M.

    2012-04-01

    Information exchange over insecure networks needs to provide authentication and confidentiality to the database in significant problem in datamining. In this paper we propose a novel authenticated multiparty ID3 Algorithm used to construct multiparty secret sharing decision tree for implementation in medical transactions.

  14. 3. BUNKER HILL LEAD SMELTER. VIEW IS FROM CIA TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. BUNKER HILL LEAD SMELTER. VIEW IS FROM CIA TO THE SOUTHWEST. BUILDINGS NOTED IN ID-29-2 APPEAR, IN ADDITION TO DRY ORE PLANT AND BONNOT COAL PULVERIZING EQUIPMENT BUILDING ON THE RIGHT. - Bunker Hill Lead Smelter, Bradley Rail Siding, Kellogg, Shoshone County, ID

  15. 75 FR 50777 - Minidoka Dam Spillway Replacement, Minidoka County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ...Pursuant to section 102(2)(C) of the National Environmental Policy Act (NEPA) of 1969, as amended, the Bureau of Reclamation (Reclamation) is notifying the public that it has prepared a FEIS on the proposed Minidoka Dam Spillway Replacement. The U.S. Fish and Wildlife Service (Department of Interior) and Rural Development (Department of Agriculture) are cooperating agencies under NEPA.......

  16. Raster Images of Geologic Maps of Middle Proterozoic Belt strata in parts of Benewah, Bonner, Kootenai and Shoshone Counties, Idaho and Lincoln, Mineral and Sanders Counties, Montana

    USGS Publications Warehouse

    Boleneus, David E.; Appelgate, Larry M.; Joseph, Nancy L.; Brandt, Theodore R.

    2001-01-01

    Geologic maps of the western part of the Belt Basin of western Montana and northern Idaho were converted into digital raster (TIFF image) format to facilitate their manipulation in geographic information systems. The 85-mile x 100-mile map area mostly contains rocks belonging to the lower and middle Belt Supergroup. The area is of interest as these Middle Proterozoic strata contain vein-type lead-zinc-silver deposits in the Coeur d?Alene Mining District in the St. Regis and Revett formations and strata-bound copper-silver deposits, such as the Troy mine, within the Revett Formation. The Prichard Formation is also prospective for strata-bound lead-zinc deposits because equivalent Belt strata in southern British Columbia, Canada host the Sullivan lead-zinc deposit. Map data converted to digital images include 13 geological maps at scales ranging from 1:48,000 to 1:12,000. Geologic map images produced from these maps by color scanning were registered to grid tick coverages in a Universal Transverse Mercator (North American Datum of 1927, zone 11) projection using ArcView Image Analysis. Geo-registering errors vary from 10 ft to 114 ft.

  17. STATE/EPA WATER QUALITY-LIMITED WATERBODIES (CWA SECT 303(D)) FOR WA, ID, OR

    EPA Science Inventory

    Major Attributes: Causes of impairment, & extent of waterbodies listed Water Quality Limited/TMDL designations (303(d)). Easily incorporated into maps at the region, county, & basin level. Scale: 1:100,000, via the digital stream reach files. Extent: WA, ID, OR. Source: WA...

  18. Risk concerns, land use, stewardship, and the Idaho National Engineering and Environmental Laboratory: attitudes of the Shoshone-Bannock and other American Indians.

    PubMed

    Burger, J; Roush, D E; Ramos, R; Gochfeld, M

    2000-07-01

    This paper examines the attitudes and perceptions of 277 American Indians about hunting and fishing, risk, and future land use of the Idaho National Engineering and Environmental Laboratory (INEEL) in southeastern Idaho. Nearly half of our sample were Shoshone-Bannock tribal members living on the nearby Fort Hall Reservation, and half were American Indians from elsewhere in the western United States. We also interviewed an additional 44 White people. We examine the hypothesis that there are differences in environmental concerns and attitudes toward future land use at IN-EEL as a function of tribal affiliation (ethnicity), educational level, gender, and age. Such perceptions are important because of the existence of tribal treaties that govern the legal and cultural rights of the Shoshone-Bannock. Returning INEEL to the Shoshone-Bannock Tribes, hunting, fishing, camping, hiking, and a National Environmental Research Park ranked as the highest preferred future land uses, whereas continuing nuclear materials reprocessing and increasing the storage of nuclear wastes ranked as the lowest. There were tribal differences in land use preferences, with those of the Fort Hall Indians being more similar to those of the local Whites than to other American Indians. All groups ranked storage of nuclear material, storage of additional nuclear material, and spills and accidents as the most serious of a list of concerns provided about the site. Fort Hall Indians answered an open-ended question with concerns for population levels and migration routes of game animals and other wildlife, more than hunting and human health. The Shoshone-Bannock from Fort Hall showed an environmental sensitivity for the well-being of wildlife and the health of the ecosystem and were interested in long-term stewardship, in addition to 29 concern for human health. PMID:10944074

  19. THE INFANT DEVELOPMENT STUDY (IDS)

    EPA Science Inventory

    A case-control study to investigate the apparent protective effect of prenatal magnesium sulfate exposure on the risk for cerebral palsy among low birthweight children. Over 200 children who have cerebral palsy, who were born in the 5-county metropolitan Atlanta area from 1981 th...

  20. 110. ROCK CREEK SIPHON, LOW LINE CANAL, TWIN FALLS COUNTY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    110. ROCK CREEK SIPHON, LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; INLET SIDE WEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  1. 149. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    149. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER DAM; CLOSE-UP OF MAIN CANAL GATES, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  2. 88. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    88. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH OF FILER, IDAHO; WEST VIEW OF CANAL AND GATES. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  3. 99. POINT SPILL, TWIN FALLS MAIN CANAL, TWIN FALLS COUNTY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    99. POINT SPILL, TWIN FALLS MAIN CANAL, TWIN FALLS COUNTY NORTHWEST OF MURTAUGH, IDAHO; CLOSE-UP OF OUTLET SIDE OF GATES, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  4. 119. COTTONWOOD CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    119. COTTONWOOD CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; INLET SIDE OF COTTONWOOD CREEK, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  5. 105. MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    105. MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; NORTHWEST VIEW OF LAKE AND HEADGATES. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  6. 123. MCMULLEN CREEK, HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    123. MCMULLEN CREEK, HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; SOUTH VIEW OF THE CREEK EMPTYING INTO THE HIGH LINE CANAL. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  7. 98. SHOESTRING, TWIN FALLS MAIN CANAL, TWIN FALLS COUNTY NORTHWEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    98. SHOESTRING, TWIN FALLS MAIN CANAL, TWIN FALLS COUNTY NORTHWEST OF MURTAUGH, IDAHO; PROFILE VIEW, SOUTH. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  8. 96. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    96. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY SOUTH OF FILER, IDAHO; OUTLET SIDE OF CEDAR DRAW, WEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  9. 120. COTTONWOOD CUT AREA, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    120. COTTONWOOD CUT AREA, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; OVERALL VIEW OF THE COTTONWOOD CREEK DRAW, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  10. 116. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    116. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY IDAHO; CLOSE-UP OF OUTLET, DIVERSION SPILL IN BACKGROUND, WEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  11. 113. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    113. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY IDAHO; CLOSE-UP OF INLET SIDE OF SIPHON, NORTHWEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  12. 95. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    95. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY SOUTH OF FILER, IDAHO; OVERALL VIEW LOOKING EAST. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  13. 103. DRY CREEK SPILL, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    103. DRY CREEK SPILL, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; INLET SIDE TO DRY CREEK, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  14. 141. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    141. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER, IDAHO; CLOSE-UP OF MAIN HEADGATES, RADIAL GATES INSIDE, SOUTHEAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  15. 97. POINT SPILL, TWIN FALLS MAIN CANAL, TWIN FALLS COUNTY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    97. POINT SPILL, TWIN FALLS MAIN CANAL, TWIN FALLS COUNTY NORTHWEST OF MURTAUGH, IDAHO; OVERALL WEST VIEW FROM CANAL SIDE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  16. 94. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    94. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY SOUTH OF FILER, IDAHO; CLOSE-UP OF GATES FROM THE CANAL SIDE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  17. 109. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    109. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF FILER, IDAHO; OVERALL VIEW LOOKING WEST. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  18. 101. DRY CREEK SPILL, MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    101. DRY CREEK SPILL, MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; NORTHEAST VIEW OF DRY CREEK OUTLET. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  19. 90. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    90. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH OF FILER, IDAHO; CLOSE-UP OF GATES. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  20. 126. COTTONWOOD CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    126. COTTONWOOD CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; CLOSE-UP OF OUTLET SIDE OF SIPHON, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  1. 122. MCMULLEN CREEK, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    122. MCMULLEN CREEK, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; INLET SIDE OF THE CREEK, ENTRANCE INTO THE HIGH LINE CANAL, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  2. 106. DRY CREEK SPILL, MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    106. DRY CREEK SPILL, MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; CLOSE-UP OF GATES, NORTHWEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  3. 102. MURTAUGH LAKE HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    102. MURTAUGH LAKE HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; LAKE SIDE OF HEADGATES, NORTHWEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  4. 112. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    112. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY IDAHO; OUTLET SIDE, EAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  5. 147. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    147. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER, IDAHO; VIEW OF MAIN HEADGATES, EAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  6. 111. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    111. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY IDAHO; OVERALL VIEW OF SIPHON, EAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  7. 93. ROCK CREEK SIPHON, LOW LINE CANAL, TWIN FALLS COUNTY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    93. ROCK CREEK SIPHON, LOW LINE CANAL, TWIN FALLS COUNTY SOUTH OF KIMBERLY, IDAHO; OVERALL NORTHEAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  8. 114. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    114. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY IDAHO; OVERALL VIEW, WEST OF INLET SIDE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  9. 124. MCMULLEN CREEK HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    124. MCMULLEN CREEK HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; OVERALL SOUTH VIEW OF DRAW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  10. 129. COTTONWOOD CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    129. COTTONWOOD CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; OUTLET SIDE OF SIPHON UNDER CANAL. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  11. 118. COTTONWOOD CREEK SPILL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    118. COTTONWOOD CREEK SPILL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; WEST VIEW OF GATES ON HIGH LINE CANAL. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  12. 121. MCMULLEN CREEK DRAW, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    121. MCMULLEN CREEK DRAW, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; OUTLET SIDE OF CREEK, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  13. 148. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    148. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER DAM; HEADGATES AT INLET, SOUTHWEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  14. 89. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    89. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH OF FILER, IDAHO; OUTLET SIDE OF CANAL, SOUTHWEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  15. 115. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    115. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY IDAHO; WEST VIEW OF SIPHON CROSSING ROCK CREEK. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  16. 117. COTTONWOOD CREEK SPILL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    117. COTTONWOOD CREEK SPILL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; CLOSE-UP OF OUTLET SIDE OF SPILL, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  17. 92. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    92. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY SOUTH OF FILER, IDAHO; CLOSE-UP OF OUTLET SIDE OF GATES, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  18. 91. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    91. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH OF FILER, IDAHO; NORTHEAST VIEW OF CANAL AND GATES. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  19. 104. DRY CREEK OUTLET (SPILL), TWIN FALLS COUNTY, SOUTH OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    104. DRY CREEK OUTLET (SPILL), TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; OUTLET FOR MURTAUGH LAKE, SOUTHEAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  20. Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

    PubMed Central

    Miyazaki, Masaki; Miyazaki, Kazuko; Chen, Shuwen; Itoi, Manami; Miller, Marina; Lu, Li-Fan; Varki, Nissi; Chang, Aaron N; Broide, David H; Murre, Cornelis

    2015-01-01

    Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We found that T cell antigen receptor (TCR)-driven signaling initially decreased the abundance of Id3, which led to the activation of a follicular regulatory T (TFR) cell–specific transcription signature. However, sustained lower abundance of Id2 and Id3 interfered with proper development of TFR cells. Depletion of Id2 and Id3 expression in Treg cells resulted in compromised maintenance and localization of the Treg cell population. Thus, Id2 and Id3 enforce TFR cell checkpoints and control the maintenance and homing of Treg cells. PMID:24973820

  1. Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease.

    PubMed

    Miyazaki, Masaki; Miyazaki, Kazuko; Chen, Shuwen; Itoi, Manami; Miller, Marina; Lu, Li-Fan; Varki, Nissi; Chang, Aaron N; Broide, David H; Murre, Cornelis

    2014-08-01

    Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We found that T cell antigen receptor (TCR)-driven signaling initially decreased the abundance of Id3, which led to the activation of a follicular regulatory T (TFR) cell-specific transcription signature. However, sustained lower abundance of Id2 and Id3 interfered with proper development of TFR cells. Depletion of Id2 and Id3 expression in Treg cells resulted in compromised maintenance and localization of the Treg cell population. Thus, Id2 and Id3 enforce TFR cell checkpoints and control the maintenance and homing of Treg cells. PMID:24973820

  2. The International Doris Service (IDS)

    NASA Astrophysics Data System (ADS)

    Tavernier, G.; Feissel-Vernier, M.; Lemoine, F.; Noll, C.; Ries, J.; Soudarin, L.; Willis, P.

    The DORIS system was developed for precise orbit determination and precise positioning on Earth. In continuation of the DORIS Pilot Experiment initiated in 1999, the International DORIS Service (IDS) officially started on July 1, 2003 as an IAG Service after the decision of the IAG Executive Committee at the IUGG General Assembly in Sapporo. Following this decision, the IERS Directing board accepted the DORIS Service as a new IERS external service. Six satellites fitted out with DORIS receivers are currently flying, permanently observed by 56 well distributed stations. Among them, three satellites equipped with new DORIS receivers (Jason-1, ENVISAT and SPOT5) have been successfully launched between Dec. 2001 and May 2002. All of them host a navigation function, called DIODE. Two new stations have been added to the permanent network in 2003: Crozet (French Southern Indian Ocean territories) and Jiufeng (China). In response to proposals submitted by candidate host agencies in the frame of IDS, the following stations were installed: Wettzell (Germany), Gavdos (radar altimeter calibration site in Crete), Lambert and Sorsdal (Glacier movement monitoring in Antarctica) in Winter 2001/2002, 2002/2003 and 2003/2004. The 2003 and early 2004 highlights include the renovation of a number of stations, reorganization of the Data Centers, and new developments in the coordination of analyses. While the Analysis Centers continue their support to IERS, the Analysis Coordinator and the Central Bureau are jointly developing comparison and combination activities that eventually aim at benefiting to the IERS Combination Pilot Project.

  3. Training for Instructional Design: Learning I.D. through the I.D. Process.

    ERIC Educational Resources Information Center

    Kemp, Jerrold E.

    1986-01-01

    Examines instructional design (ID) courses offered in instructional technology masters program at San Jose State University. Course objectives, participants' needs assessment, resources and study methods, and student evaluation are discussed for introductory ID course; learning activities of advanced ID seminar are outlined. Sample student

  4. A late Frasnian (Late Devonian) radiolarian, sponge spicule, and conodont fauna from the Slaven Chert, northern Shoshone Range, Roberts Mountains allochthon, Nevada

    USGS Publications Warehouse

    Boundy-Sanders, S. Q.; Sandberg, C.A.; Murchey, B.L.; Harris, A.G.

    1999-01-01

    Co-occuring conodonts, radiolarians, and sponge spicules from the type locality of the Slaven Chert, northern Shoshone Range, Nevada, indicate that the radiolarian and sponge spicule assemblage described herein correlates with the Late rhenana conodont Zone (late Frasnian). The moderately well preserved radiolarians are the first Frasnian-age fauna described from the Western Hemisphere. They include spumellarians, Ceratoikiscum, and Paleoscenidium, and a radiolarian which we have assigned to a new genus, Durahelenifore Boundy-Sanders and Murchey, with its type species, Durahelenifore robustum Boundy-Sanders and Murchey. Sponge spicules include umbellate microscleres of the Subclass Amphidiscophora, Order Hemidiscosa, previously documented only in Pennsylvanian and younger rocks.

  5. A vulnerability tool for adapting water and aquatic resources to climate change and extremes on the Shoshone National Forest, Wyoming

    NASA Astrophysics Data System (ADS)

    Rice, J.; Joyce, L. A.; Armel, B.; Bevenger, G.; Zubic, R.

    2011-12-01

    Climate change introduces a significant challenge for land managers and decision makers managing the natural resources that provide many benefits from forests. These benefits include water for urban and agricultural uses, wildlife habitat, erosion and climate control, aquifer recharge, stream flows regulation, water temperature regulation, and cultural services such as outdoor recreation and aesthetic enjoyment. The Forest Service has responded to this challenge by developing a national strategy for responding to climate change (the National Roadmap for Responding to Climate Change, July 2010). In concert with this national strategy, the Forest Service's Westwide Climate Initiative has conducted 4 case studies on individual Forests in the western U.S to develop climate adaptation tools. Western National Forests are particularly vulnerable to climate change as they have high-mountain topography, diversity in climate and vegetation, large areas of water limited ecosystems, and increasing urbanization. Information about the vulnerability and capacity of resources to adapt to climate change and extremes is lacking. There is an urgent need to provide customized tools and synthesized local scale information about the impacts to resources from future climate change and extremes, as well as develop science based adaptation options and strategies in National Forest management and planning. The case study on the Shoshone National Forest has aligned its objectives with management needs by developing a climate extreme vulnerability tool that guides adaptation options development. The vulnerability tool determines the likely degree to which native Yellowstone cutthroat trout and water availability are susceptible to, or unable to cope with adverse effects of climate change extremes. We spatially categorize vulnerability for water and native trout resources using exposure, sensitivity, and adaptive capacity indicators that use minimum and maximum climate and GIS data. Results show that the vulnerability of water availability may increase in areas that have less storage and become more dominated by rain instead of snow. Native trout habitat was found to improve in some areas from warmer temperatures suggesting future refugia habitat may need to be a focus of conservation efforts. The climate extreme vulnerability tool provides Forest Service resource managers science based information that guides adaptation strategy development; prioritize conservation projects; guides monitoring efforts, and helps promote more resilient ecosystems undergoing the effects of climate change.

  6. 2. PHOSPHATE UNLOADING BUILDING. VIEW IS TO THE NORTH. THIS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. PHOSPHATE UNLOADING BUILDING. VIEW IS TO THE NORTH. THIS STRUCTURE WAS RELOCATED TO THE SOUTH OF ITS ORIGINAL SITE IN 1993 FOR USE AS A DECONTAMINATION FACILITY WITHIN THE BUNKER HILL SUPERFUND SITE. - North Idaho Phosphate Company, Silver King Community, Kellogg, Shoshone County, ID

  7. AFRD WAREHOUSE, INTERIOR, FACING WEST. TWO ROWS OF ORIGINAL WOOD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AFRD WAREHOUSE, INTERIOR, FACING WEST. TWO ROWS OF ORIGINAL WOOD POSTS SUPPORT CEILING RAFTERS. SHEETROCK ON CEILING AND WALLS IS AN ALTERATION MADE BY THE AFRD. LOFT NEAR CENTER OF VIEW MAY HAVE BEEN PART OF THE ORIGINAL BUILDING. - Minidoka Relocation Center Warehouse, 111 South Fir Street, Shoshone, Lincoln County, ID

  8. AFRD WAREHOUSE, WEST SIDE, FACING EAST. NOTE PLACEMENT OF METAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AFRD WAREHOUSE, WEST SIDE, FACING EAST. NOTE PLACEMENT OF METAL SIDING BETWEEN THE TWO HALVES OF THE SLIDING DOOR. ORIGINAL 8-PANE WINDOW HAS BEEN REPLACED BY A SINGLE PANE OF GLASS. CONCRETE BRICK CHIMNEY IS AT LEFT OF VIEW. - Minidoka Relocation Center Warehouse, 111 South Fir Street, Shoshone, Lincoln County, ID

  9. AFRD WAREHOUSE, WEST SIDE DETAIL OF ALTERED SLIDING DOORS, FACING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AFRD WAREHOUSE, WEST SIDE DETAIL OF ALTERED SLIDING DOORS, FACING EAST. WEATHER COVER OVER RAIL IS ORIGINAL. SHEET METAL SIDING HAS BEEN INSERTED BETWEEN TWO HALVES OF SLIDING DOORS. - Minidoka Relocation Center Warehouse, 111 South Fir Street, Shoshone, Lincoln County, ID

  10. AFRD WAREHOUSE, EAST SIDE DETAIL SHOWS CONNECTION OF LEANTO TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AFRD WAREHOUSE, EAST SIDE DETAIL SHOWS CONNECTION OF LEAN-TO TO WALL. FACING WEST. NOTE THE PROFILE OF THE METAL AWNING ON SOUTH SIDE. ELECTRICAL CONDUIT AND OTHER SERVICES PENETRATE WALL. POLE SECURED WITH TRIANGULAR BRACES AT CORNER IS COMMUNICATION POLE. - Minidoka Relocation Center Warehouse, 111 South Fir Street, Shoshone, Lincoln County, ID

  11. 1. BUNKER HILL LEAD SMELTER. VIEW IS FROM CENTRAL IMPOUNDMENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. BUNKER HILL LEAD SMELTER. VIEW IS FROM CENTRAL IMPOUNDMENT AREA LOOKING SOUTH. PLANT DRY IS IN CENTER FOREGROUND, SLAG FUMING PLANT IS IN RIGHT FOREGROUND, AND BAG HOUSE IS IN RIGHT BACKGROUND. VARIOUS PLANT STACKS ARE ALSO VISIBLE. - Bunker Hill Lead Smelter, Bradley Rail Siding, Kellogg, Shoshone County, ID

  12. 2. BUNKER HILL LEAD SMELTER. VIEW IS FROM CIA TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. BUNKER HILL LEAD SMELTER. VIEW IS FROM CIA TO THE SOUTH. IN FOREGROUND, PLANT DRY, SLAG FUMING PLANT, BLAST FURNACE, SMELTER OFFICE, LEAD AND SILVER REFINERIES ARE VISIBLE, L. TO R. HIGH VELOCITY FLUE LEADS FROM LOWER PLANT TO BAG HOUSE AND STACKS AT TOP OF SMELTING FACILITY. - Bunker Hill Lead Smelter, Bradley Rail Siding, Kellogg, Shoshone County, ID

  13. 1. NORTH IDAHO PHOSPHATE COMPANY PLANTS. VIEW IS TO THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. NORTH IDAHO PHOSPHATE COMPANY PLANTS. VIEW IS TO THE NORTHEAST, WITH THE SHIPPING AND STORAGE WAREHOUSE, AMMONIUM PHOSPHATE FERTILIZER PLANT, AND PHOSPHORIC ACID PLANT APPEARING IN SUCCESSION DOWN GOVERNMENT GULCH. - North Idaho Phosphate Company, Silver King Community, Kellogg, Shoshone County, ID

  14. Id-1 and Id-2 genes and products as markers of epithelial cancer

    DOEpatents

    Desprez, Pierre-Yves; Campisi, Judith

    2011-10-04

    A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

  15. Id-1 and Id-2 genes and products as markers of epithelial cancer

    DOEpatents

    Desprez, Pierre-Yves; Campisi, Judith

    2008-09-30

    A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

  16. 75 FR 81269 - Ward Transformer Superfund Site Raleigh, Wake County, NC; Notice of Settlements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... AGENCY Ward Transformer Superfund Site Raleigh, Wake County, NC; Notice of Settlements AGENCY... Ward Transformer Superfund Site located in Raleigh, Wake County, North Carolina for publication. DATES... your comments, identified by Docket ID No. EPA-RO4- SFUND-2010-1053 or Site name Ward...

  17. 76 FR 14970 - National Starch and Chemical Company, Salisbury, Rowan County, NC; Notice of Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ... AGENCY National Starch and Chemical Company, Salisbury, Rowan County, NC; Notice of Settlement AGENCY... National Starch and Chemical Company Site located in Mobile, Mobile County, Alabama for publication. DATES..., identified by Docket ID No. EPA-RO4- SFUND-2011-0278 or Site name National Starch and Chemical...

  18. 75 FR 67968 - Arkwright Dump Site, Spartanburg, Spartanburg County, SC; Notice of Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... AGENCY Arkwright Dump Site, Spartanburg, Spartanburg County, SC; Notice of Settlement AGENCY... Arkwright Dump Site located in Spartanburg, Spartanburg County, South Carolina for publication. DATES: The..., identified by Docket ID No. EPA-RO4- SFUND-2010-0892 or Site name Arkwright Dump Site by one of the...

  19. 75 FR 52360 - Upper Truckee River Restoration and Golf Course Reconfiguration Project, El Dorado County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... Bureau of Reclamation Upper Truckee River Restoration and Golf Course Reconfiguration Project, El Dorado... ; http://www.parks.ca.gov/?page_id=981 (click on El Dorado County); http://www.trpa.org ; http://www.usbr... and south of the City of South Lake Tahoe, within El Dorado County, California. It includes...

  20. 76 FR 11779 - Puckett Smelter Superfund Site; Mountainboro, Etowah County, AL; Notice of Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... AGENCY Puckett Smelter Superfund Site; Mountainboro, Etowah County, AL; Notice of Settlement AGENCY... Puckett Smelter Superfund Site located in Mountainboro, Etowah county, Alabama for publication. DATES: The..., identified by Docket ID No. EPA-RO4- SFUND-2011-0149 or Site name Puckett Smelter Superfund Site by one...

  1. 76 FR 62387 - Public User ID Badging

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... United States Patent and Trademark Office Public User ID Badging ACTION: Proposed collection; comment..., United States Patent and Trademark Office, P.O. Box 1450, Alexandria, VA 22313-1450. Federal Rulemaking... Search Facility, United States Patent and Trademark Office, P.O. Box 1450, Alexandria, VA 22313-1450;...

  2. 76 FR 31388 - Idaho Disaster #ID-00014

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Idaho Disaster ID-00014 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This... E. Rivera Associate Administrator for Disaster Assistance. BILLING CODE 8025-01-P...

  3. 75 FR 45682 - Idaho Disaster #ID-00010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Idaho Disaster ID-00010 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This... E. Rivera, Associate Administrator for Disaster Assistance. BILLING CODE 8025-01-P...

  4. The Evolving "D" in "Basic ID."

    ERIC Educational Resources Information Center

    Gerler, Edwin R.

    1979-01-01

    The multimodal model uses the acronym BASIC ID to identify areas of client functioning that frequently need to be treated. The D mode includes drugs, diet, and other physiological factors. This article describes the evolution of the D mode and shows the importance of a physiological dimension to multimodal counseling. (Author)

  5. What Is "Real-World" ID Anyway?

    ERIC Educational Resources Information Center

    Hardre, Patricia L.

    2013-01-01

    The term "real-world ID" is commonly heard at professional conferences, but its meaning is assumed rather than defined. Unless we examine the meanings and implications of rhetoric of the field, we risk error in presenting ourselves, and we risk derailing the progress of our profession. This article examines the term "real world" as applied to

  6. BOISE RIVER STUDY IN ADA COUNTY IDAHO, 1978

    EPA Science Inventory

    The purpose of this study was to assess the impact of present point sources on the river and to obtain background information to develop effluent limitations for the City of Boise wastewater treatment facilities. The study was conducted on the Boise River (Ada County, ID) from L...

  7. Inhibitor of Differentiation 4 (ID4): From Development to Cancer

    PubMed Central

    Patel, Divya; Morton, Derrick J; Carey, Jason; Havrda, Mathew C; Chaudhary, Jaideep

    2014-01-01

    Highly conserved Inhibitor of DNA Binding (ID1-4) genes encode multi-functional proteins whose transcriptional activity is based on dominant negative inhibition of basic helix-loop-helix (bHLH) transcription factors. Initial animal models indicated a degree of compensatory overlap between ID genes such that deletion of multiple ID genes was required to generate easily recognizable phenotypes. More recently, new model systems have revealed alterations in mice harboring deletions in single ID genes suggesting complex gene and tissue specific functions for members of the ID gene family. Because ID genes are highly expressed during development and their function is associated with a primitive, proliferative cellular phenotype there has been significant interest in understanding their potential roles in neoplasia. Indeed, numerous studies indicate an oncogenic function for ID1, 2 and 3. In contrast, the inhibitor of differentiation 4 (ID4) presents a paradigm shift in context of well-established role of ID1, 2 and 3 in development and cancer. Apart from some degree of functional redundancy such as HLH dependent interactions with bHLH protein E2A, many of the functions of ID4 are distinct from ID1, 2 and 3: ID4 proteins a) regulate distinct developmental processes and tissue expression in the adult, b) promotes stem cell survival, differentiation and/or timing of differentiation, c) epigenetic inactivation/loss of expression in several advanced stage cancers and d) increased expression in some cancers such as those arising in the breast and ovary. Thus, in spite of sharing the conserved HLH domain, ID4 defies the established model of ID protein function and expression. The underlying molecular mechanism responsible for the unique role of ID4 as compared to other ID proteins still remains largely un-explored. This review will focus on the current understanding of ID4 in context of development and cancer. PMID:25512197

  8. Estimation of unsaturated zone traveltimes for Rainier Mesa and Shoshone Mountain, Nevada Test Site, Nevada, using a source-responsive preferential-flow model

    SciTech Connect

    Brian A. Ebel; John R. Nimmo

    2009-09-11

    Traveltimes for contaminant transport by water from a point in the unsaturated zone to the saturated zone are a concern at Rainier Mesa and Shoshone Mountain in the Nevada Test Site, Nevada. Where nuclear tests were conducted in the unsaturated zone, contaminants must traverse hundreds of meters of variably saturated rock before they enter the saturated zone in the carbonate rock, where the regional groundwater system has the potential to carry them substantial distances to a location of concern. The unsaturated-zone portion of the contaminant transport path may cause a significant delay, in addition to the time required to travel within the saturated zone, and thus may be important in the overall evaluation of the potential hazard from contamination. Downward contaminant transport through the unsaturated zone occurs through various processes and pathways; this can lead to a broad distribution of contaminant traveltimes, including exceedingly slow and unexpectedly fast extremes. Though the bulk of mobile contaminant arrives between the time-scale end members, the fastest contaminant transport speed, in other words the speed determined by the combination of possible processes and pathways that would bring a measureable quantity of contaminant to the aquifer in the shortest time, carries particular regulatory significance because of its relevance in formulating the most conservative hazard-prevention scenarios. Unsaturated-zone flow is usually modeled as a diffusive process responding to gravity and pressure gradients as mediated by the unsaturated hydraulic properties of the materials traversed. The mathematical formulation of the diffuse-flow concept is known as Richards' equation, which when coupled to a solute transport equation, such as the advection-dispersion equation, provides a framework to simulate contaminant migration in the unsaturated zone. In recent decades awareness has increased that much fluid flow and contaminant transport within the unsaturated zone takes place as preferential flow, faster than would be predicted by the coupled Richards' and advection-dispersion equations with hydraulic properties estimated by traditional means. At present the hydrologic community has not achieved consensus as to whether a modification of Richards' equation, or a fundamentally different formulation, would best quantify preferential flow. Where the fastest contaminant transport speed is what needs to be estimated, there is the possibility of simplification of the evaluation process. One way of doing so is by a two-step process in which the first step is to evaluate whether significant preferential flow and solute transport is possible for the media and conditions of concern. The second step is to carry out (a) a basic Richards' and advection-dispersion equation analysis if it is concluded that preferential flow is not possible or (b) an analysis that considers only the fastest possible preferential-flow processes, if preferential flow is possible. For the preferential-flow situation, a recently published model describable as a Source-Responsive Preferential-Flow (SRPF) model is an easily applied option. This report documents the application of this two-step process to flow through the thick unsaturated zones of Rainier Mesa and Shoshone Mountain in the Nevada Test Site. Application of the SRPF model involves distinguishing between continuous and intermittent water supply to preferential flow paths. At Rainier Mesa and Shoshone Mountain this issue is complicated by the fact that contaminant travel begins at a location deep in the subsurface, where there may be perched water that may or may not act like a continuous supply, depending on such features as the connectedness of fractures and the nature of impeding layers. We have treated this situation by hypothesizing both continuous and intermittent scenarios for contaminant transport to the carbonate aquifer and reporting estimation of the fastest speed for both of these end members.

  9. Estimation of Unsaturated Zone Traveltimes for Rainier Mesa and Shoshone Mountain, Nevada Test Site, Nevada, Using a Source-Responsive Preferential-Flow Model

    USGS Publications Warehouse

    Ebel, Brian A.; Nimmo, John R.

    2009-01-01

    Traveltimes for contaminant transport by water from a point in the unsaturated zone to the saturated zone are a concern at Rainier Mesa and Shoshone Mountain in the Nevada Test Site, Nevada. Where nuclear tests were conducted in the unsaturated zone, contaminants must traverse hundreds of meters of variably saturated rock before they enter the saturated zone in the carbonate rock, where the regional groundwater system has the potential to carry them substantial distances to a location of concern. The unsaturated-zone portion of the contaminant transport path may cause a significant delay, in addition to the time required to travel within the saturated zone, and thus may be important in the overall evaluation of the potential hazard from contamination. Downward contaminant transport through the unsaturated zone occurs through various processes and pathways; this can lead to a broad distribution of contaminant traveltimes, including exceedingly slow and unexpectedly fast extremes. Though the bulk of mobile contaminant arrives between the time-scale end members, the fastest contaminant transport speed, in other words the speed determined by the combination of possible processes and pathways that would bring a measureable quantity of contaminant to the aquifer in the shortest time, carries particular regulatory significance because of its relevance in formulating the most conservative hazard-prevention scenarios. Unsaturated-zone flow is usually modeled as a diffusive process responding to gravity and pressure gradients as mediated by the unsaturated hydraulic properties of the materials traversed. The mathematical formulation of the diffuse-flow concept is known as Richards' equation, which when coupled to a solute transport equation, such as the advection-dispersion equation, provides a framework to simulate contaminant migration in the unsaturated zone. In recent decades awareness has increased that much fluid flow and contaminant transport within the unsaturated zone takes place as preferential flow, faster than would be predicted by the coupled Richards' and advection-dispersion equations with hydraulic properties estimated by traditional means. At present the hydrologic community has not achieved consensus as to whether a modification of Richards' equation, or a fundamentally different formulation, would best quantify preferential flow. Where the fastest contaminant transport speed is what needs to be estimated, there is the possibility of simplification of the evaluation process. One way of doing so is by a two-step process in which the first step is to evaluate whether significant preferential flow and solute transport is possible for the media and conditions of concern. The second step is to carry out (a) a basic Richards' and advection-dispersion equation analysis if it is concluded that preferential flow is not possible or (b) an analysis that considers only the fastest possible preferential-flow processes, if preferential flow is possible. For the preferential-flow situation, a recently published model describable as a Source-Responsive Preferential-Flow (SRPF) model is an easily applied option. This report documents the application of this two-step process to flow through the thick unsaturated zones of Rainier Mesa and Shoshone Mountain in the Nevada Test Site. Application of the SRPF model involves distinguishing between continuous and intermittent water supply to preferential flow paths. At Rainier Mesa and Shoshone Mountain this issue is complicated by the fact that contaminant travel begins at a location deep in the subsurface, where there may be perched water that may or may not act like a continuous supply, depending on such features as the connectedness of fractures and the nature of impeding layers. We have treated this situation by hypothesizing both continuous and intermittent scenarios for contaminant transport to the carbonate aquifer and reporting estimation of the fastest speed for both of th

  10. Remembering One's ID/E-ntity : E/ID Protein Regulation of T Cell Memory

    PubMed Central

    Omilusik, Kyla D.; Shaw, Laura A.; Goldrath, Ananda W.

    2013-01-01

    Upon infection, CD8+ T cells proliferate and differentiate into armed effector cells capable of eliminating the assaulting pathogen. Although the majority of the antigen-specific T cells will die as the immune response wanes, a few will survive indefinitely to establish the memory population and provide long-lived protection against reinfection. E protein transcription factors and their inhibitors, ID proteins, operate to balance expression of genes that control CD8+ T cell differentiation through this process. Here, we discuss the role of ID2 and ID3 in promoting the generation and survival of effector and memory populations, particularly highlighting their reciprocal roles in shaping the CD8+ T cell response unique to the inflammatory milieu. We further examine this coordinated control of gene expression in the context of additional transcription factors within the transcriptional network that programs CD8+ effector and memory T cell differentiation. PMID:24094885

  11. Minimum silicon wafer thickness for ID wafering

    NASA Technical Reports Server (NTRS)

    Chen, C. P.

    1982-01-01

    An analytical model, based on fracture mechanics analysis, is proposed for estimating the minimum wafer thickness as a function of the diameter requirement for solar cells. The conditions under which the model can be applied are discussed with reference to the critical flaw size, the applied force, and the width of the side support. It is shown that the equivalent cantilever force applied during ID slicing can be estimated from the wafering mechanical yield data. The width of the wafer side support was found to be a significant factor in controlling the minimum allowable wafer thickness during slicing. Wafer side support width requirements were found to increase with decreasing wafer thickness.

  12. The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.

    PubMed

    Yang, Cliff Y; Best, J Adam; Knell, Jamie; Yang, Edward; Sheridan, Alison D; Jesionek, Adam K; Li, Haiyan S; Rivera, Richard R; Lind, Kristin Camfield; D'Cruz, Louise M; Watowich, Stephanie S; Murre, Cornelis; Goldrath, Ananda W

    2011-12-01

    During infection, naive CD8(+) T cells differentiate into effector cells, which are armed to eliminate pathogens, and memory cells, which are poised to protect against reinfection. The transcriptional program that regulates terminal differentiation into short-lived effector-memory versus long-lived memory cells is not clearly defined. Through the use of mice expressing reporters for the DNA-binding inhibitors Id2 and Id3, we identified Id3(hi) precursors of long-lived memory cells before the peak of T cell population expansion or upregulation of cell-surface receptors that indicate memory potential. Deficiency in Id2 or Id3 resulted in loss of distinct CD8(+) effector and memory populations, which demonstrated unique roles for these inhibitors of E-protein transcription factors. Furthermore, cytokines altered the expression of Id2 and Id3 differently, which provides insight into how external cues influence gene expression. PMID:22057289

  13. Low Physical Fitness Levels in Older Adults with ID: Results of the HA-ID Study

    ERIC Educational Resources Information Center

    Hilgenkamp, Thessa I. M.; van Wijck, Ruud; Evenhuis, Heleen M.

    2012-01-01

    Physical fitness is as important to aging adults with ID as in the general population, but to date, the physical fitness levels of this group are unknown. Comfortable walking speed, muscle strength (grip strength), muscle endurance (30 s Chair stand) and cardiorespiratory endurance (10 m incremental shuttle walking test) were tested in a sample of…

  14. Low Physical Fitness Levels in Older Adults with ID: Results of the HA-ID Study

    ERIC Educational Resources Information Center

    Hilgenkamp, Thessa I. M.; van Wijck, Ruud; Evenhuis, Heleen M.

    2012-01-01

    Physical fitness is as important to aging adults with ID as in the general population, but to date, the physical fitness levels of this group are unknown. Comfortable walking speed, muscle strength (grip strength), muscle endurance (30 s Chair stand) and cardiorespiratory endurance (10 m incremental shuttle walking test) were tested in a sample of

  15. To ID or Not to ID? Changes in Classification Rates of Intellectual Disability Using "DSM-5"

    ERIC Educational Resources Information Center

    Papazoglou, Aimilia; Jacobson, Lisa A.; McCabe, Marie; Kaufmann, Walter; Zabel, T. Andrew

    2014-01-01

    The "Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition" ("DSM-5") diagnostic criteria for intellectual disability (ID) include a change to the definition of adaptive impairment. New criteria require impairment in one adaptive domain rather than two or more skill areas. The authors examined the diagnostic

  16. DRAFT LANDSAT DATA MOSAIC: MONTGOMERY COUNTY, TEXAS; HARRIS COUNTY, TEXAS; FORT BEND COUNTY, TEXAS; BRAZORIA COUNTY, TEXAS; GALVESTON COUNTY, TEXAS

    EPA Science Inventory

    This is a draft Landsat Data Mosaic, which contains remote sensing information for Montgomery County, Texas Harris County, Texas Fort Bend County, Texas Brazoria County, Texas Galveston County, and Texas Imagery dates on the following dates: October 6, 1999 and September 29, 200...

  17. Evidence for large-magnitude, post-Eocene extension in the northern Shoshone Range, Nevada, and its implications for Carlin-type gold deposits in the lower plate of the Roberts Mountains allochthon

    USGS Publications Warehouse

    Colgan, Joseph P.; Henry, Christopher D.; John, David A.

    2014-01-01

    The northern Shoshone and Toiyabe Ranges in north-central Nevada expose numerous areas of mineralized Paleozoic rock, including major Carlin-type gold deposits at Pipeline and Cortez. Paleozoic rocks in these areas were previously interpreted to have undergone negligible postmineralization extension and tilting, but here we present new data that suggest major post-Eocene extension along west-dipping normal faults. Tertiary rocks in the northern Shoshone Range crop out in two W-NW–trending belts that locally overlie and intrude highly deformed Lower Paleozoic rocks of the Roberts Mountains allochthon. Tertiary exposures in the more extensive, northern belt were interpreted as subvertical breccia pipes (intrusions), but new field data indicate that these “pipes” consist of a 35.8 Ma densely welded dacitic ash flow tuff (informally named the tuff of Mount Lewis) interbedded with sandstones and coarse volcaniclastic deposits. Both tuff and sedimentary rocks strike N-S and dip 30° to 70° E; the steeply dipping compaction foliation in the tuffs was interpreted as subvertical flow foliation in breccia pipes. The southern belt along Mill Creek, previously mapped as undivided welded tuff, includes the tuff of Cove mine (34.4 Ma) and unit B of the Bates Mountain Tuff (30.6 Ma). These tuffs dip 30° to 50° east, suggesting that their west-dipping contacts with underlying Paleozoic rocks (previously mapped as depositional) are normal faults. Tertiary rocks in both belts were deposited on Paleozoic basement and none appear to be breccia pipes. We infer that their present east tilt is due to extension on west-dipping normal faults. Some of these faults may be the northern strands of middle Miocene (ca. 16 Ma) faults that cut and tilted the 34.0 Ma Caetano caldera ~40° east in the central Shoshone Range (

  18. Geologic Surface Effects of Underground Nuclear Testing, Buckboard Mesa, Climax Stock, Dome Mountain, Frenchman Flat, Rainier/Aqueduct Mesa, and Shoshone Mountain, Nevada Test Site, Nevada

    USGS Publications Warehouse

    Grasso, Dennis N.

    2003-01-01

    Surface effects maps were produced for 72 of 89 underground detonations conducted at the Frenchman Flat, Rainier Mesa and Aqueduct Mesa, Climax Stock, Shoshone Mountain, Buckboard Mesa, and Dome Mountain testing areas of the Nevada Test Site between August 10, 1957 (Saturn detonation, Area 12) and September 18, 1992 (Hunters Trophy detonation, Area 12). The ?Other Areas? Surface Effects Map Database, which was used to construct the maps shown in this report, contains digital reproductions of these original maps. The database is provided in both ArcGIS (v. 8.2) geodatabase format and ArcView (v. 3.2) shapefile format. This database contains sinks, cracks, faults, and other surface effects having a combined (cumulative) length of 136.38 km (84.74 mi). In GIS digital format, the user can view all surface effects maps simultaneously, select and view the surface effects of one or more sites of interest, or view specific surface effects by area or site. Three map layers comprise the database. They are: (1) the surface effects maps layer (oase_n27f), (2) the bar symbols layer (oase_bar_n27f), and (3) the ball symbols layer (oase_ball_n27f). Additionally, an annotation layer, named 'Ball_and_Bar_Labels,' and a polygon features layer, named 'Area12_features_poly_n27f,' are contained in the geodatabase version of the database. The annotation layer automatically labels all 295 ball-and-bar symbols shown on these maps. The polygon features layer displays areas of ground disturbances, such as rock spall and disturbed ground caused by the detonations. Shapefile versions of the polygon features layer in Nevada State Plane and Universal Transverse Mercator projections, named 'area12_features_poly_n27f.shp' and 'area12_features_poly_u83m.shp,' are also provided in the archive.

  19. An ID2-dependent mechanism for VHL inactivation in cancer.

    PubMed

    Lee, Sang Bae; Frattini, Veronique; Bansal, Mukesh; Castano, Angelica M; Sherman, Dan; Hutchinson, Keino; Bruce, Jeffrey N; Califano, Andrea; Liu, Guangchao; Cardozo, Timothy; Iavarone, Antonio; Lasorella, Anna

    2016-01-14

    Mechanisms that maintain cancer stem cells are crucial to tumour progression. The ID2 protein supports cancer hallmarks including the cancer stem cell state. HIF? transcription factors, most notably HIF2? (also known as EPAS1), are expressed in and required for maintenance of cancer stem cells (CSCs). However, the pathways that are engaged by ID2 or drive HIF2? accumulation in CSCs have remained unclear. Here we report that DYRK1A and DYRK1B kinases phosphorylate ID2 on threonine 27 (Thr27). Hypoxia downregulates this phosphorylation via inactivation of DYRK1A and DYRK1B. The activity of these kinases is stimulated in normoxia by the oxygen-sensing prolyl hydroxylase PHD1 (also known as EGLN2). ID2 binds to the VHL ubiquitin ligase complex, displaces VHL-associated Cullin 2, and impairs HIF2? ubiquitylation and degradation. Phosphorylation of Thr27 of ID2 by DYRK1 blocks ID2-VHL interaction and preserves HIF2? ubiquitylation. In glioblastoma, ID2 positively modulates HIF2? activity. Conversely, elevated expression of DYRK1 phosphorylates Thr27 of ID2, leading to HIF2? destabilization, loss of glioma stemness, inhibition of tumour growth, and a more favourable outcome for patients with glioblastoma. PMID:26735018

  20. Id4 Marks Spermatogonial Stem Cells in the Mouse Testis.

    PubMed

    Sun, Feng; Xu, Qing; Zhao, Danfeng; Degui Chen, Charlie

    2015-01-01

    Mammalian spermatogenesis is a classic adult stems cell-dependent process, supported by the self-renewal and differentiation of spermatogonial stem cells (SSCs). However, the identification of SSCs and elucidation of their behaviors in undisturbed testis has long been a big challenge. Here, we generated a knock-in mouse model, Id4-2A-CreERT2-2A-tdTomato, which allowed us to mark Id4-expressing (Id4(+)) cells at different time points in situ and track their behaviors across distinct developmental stages during steady-state and regenerating spermatogenesis. We found that Id4(+) cells continue to produce spermatogonia, spermatocytes and sperm in mouse testis, showing they are capable of self-renewal and have differentiation potential. Consistent with these findings, ablation of Id4(+) cells in mice results in a loss of spermatogenesis. Furthermore, developmental fate mapping reveals that Id4(+) SSCs originate from neonate Id4(+) gonocytes. Therefore, our results indicate that Id4 marks spermatogonial stem cells in the mouse testis. PMID:26621350

  1. Id4 Marks Spermatogonial Stem Cells in the Mouse Testis

    PubMed Central

    Sun, Feng; Xu, Qing; Zhao, Danfeng; Degui Chen, Charlie

    2015-01-01

    Mammalian spermatogenesis is a classic adult stems cell–dependent process, supported by the self-renewal and differentiation of spermatogonial stem cells (SSCs). However, the identification of SSCs and elucidation of their behaviors in undisturbed testis has long been a big challenge. Here, we generated a knock-in mouse model, Id4-2A-CreERT2-2A-tdTomato, which allowed us to mark Id4-expressing (Id4+) cells at different time points in situ and track their behaviors across distinct developmental stages during steady-state and regenerating spermatogenesis. We found that Id4+ cells continue to produce spermatogonia, spermatocytes and sperm in mouse testis, showing they are capable of self-renewal and have differentiation potential. Consistent with these findings, ablation of Id4+ cells in mice results in a loss of spermatogenesis. Furthermore, developmental fate mapping reveals that Id4+ SSCs originate from neonate Id4+ gonocytes. Therefore, our results indicate that Id4 marks spermatogonial stem cells in the mouse testis. PMID:26621350

  2. ID Model Construction and Validation: A Multiple Intelligences Case

    ERIC Educational Resources Information Center

    Tracey, Monica W.; Richey, Rita C.

    2007-01-01

    This is a report of a developmental research study that aimed to construct and validate an instructional design (ID) model that incorporates the theory and practice of multiple intelligences (MI). The study consisted of three phases. In phase one, the theoretical foundations of multiple Intelligences and ID were examined to guide the development

  3. Proteomic analysis of Nipponia nippon (ID#162).

    PubMed

    Oyanagi, Mitsuru; Kaneko, Kentaro; Kaneko, Yoshinori; Sasaki, Maiko; Nishida, Chizuko; Matsuda, Yoichi; Mitsui, Toshiaki

    2014-08-01

    We investigated the proteome of a female Crested Ibis (Nipponia nippon,?ID#162) that died on March 10, 2010 at the Sado Japanese Crested Ibis Conservation Center. Protein preparations from the brain, trachea, liver, heart, lung, proventriculus, muscular stomach, small intestine, duodenum, ovary and neck muscle were subjected to in-solution shotgun mass spectrometry (MS)/MS analyses using an LTQ Orbitrap XL mass spectrometer. A search of the National Center for Biotechnology Information Gallus gallus databases revealed 4253 GI (GenInfo Identifier) numbers with the sum of the same 11 tissues examined in the Crested Ibis. To interpret the obtained proteomics data, it was verified in detail with the data obtained from the brain of the Crested Ibis. It has been reported that drebrin A is specifically expressed in adult chicken brain. In the shotgun proteomic analyses of the Crested Ibis, we identified drebrin A as a brain-specific protein. Furthermore, Western blotting analysis of the protein preparations from 10 tissues of the Crested Ibis and 150-day-old hens using anti-drebrin antibodies showed intensive expression of approximately 110?kDa polypeptides of drebrin in both brains. We believe firmly that the present data will contribute to initial and fundamental steps toward understanding the Crested Ibis proteome. PMID:24961376

  4. Id-1 and Id-2 genes and products as therapeutic targets for treatment of breast cancer and other types of carcinoma

    DOEpatents

    Desprez, Pierre-Yves; Campisi, Judith

    2014-09-30

    A method for treatment and amelioration of breast, cervical, ovarian, endometrial, squamous cells, prostate cancer and melanoma in a patient comprising targeting Id-1 or Id-2 gene expression with a delivery vehicle comprising a product which modulates Id-1 or Id-2 expression.

  5. Biometric authentication for ID cards with hologram watermarks

    NASA Astrophysics Data System (ADS)

    Croce Ferri, Lucilla; Mayerhoefer, Astrid; Frank, Marcus; Vielhauer, Claus; Steinmetz, Ralf

    2002-04-01

    We present an analysis of a new technique for the authentication of ID cardholders, based on the integration of a biometrics-based authentication system with digital watermarks. The chosen biometric authentication method is the dynamic signature verification of the ID cardholder, while we use a specific integrity watermark technique we developed, called Hologram Watermark, to embed and retrieve the off-line data onto an ID card. We take advantage of the fact, that two static biometric features (images of the user's face and signature) are already integral part of ID cards for manual verification and extent the stored biometric information by embedding on-line handwriting features of the signature as holographic watermarks in the overall image information of an ID card. Manipulation of any of the image information can be detected and will further disallow biometric verification of the forger. The Hologram Watermark technique produces content-related data using computer-generated hologram coding techniques. These data are embedded with watermarking techniques into the personal data printed on an ID card. The content-related data in this specific application are the dynamic features of the cardholder's signature. The main goal of this paper is to analyze the suitability of dynamic signature verification in combination with the Hologram Watermark technique, to facilitate automated user authentication based on information transparently embedded in ID cards.

  6. 75 FR 39365 - Revisions to the California State Implementation Plan, Imperial County Air Pollution Control...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... minimis level. Id. at 42011. \\19\\ 75 FR 8008, 8010, and proposal TSD, pp. 5-7. Open areas: --Windblown... Order Reviews I. Summary of Proposed Action On February 23, 2010 (75 FR 8008), EPA proposed a limited... section E.6 for recreational use of public lands in Imperial County. \\6\\ 75 FR 8008, 8010-8011 and...

  7. 76 FR 19096 - National Starch and Chemical Company, Salisbury, Rowan County, North Carolina; Notice of Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... AGENCY National Starch and Chemical Company, Salisbury, Rowan County, North Carolina; Notice of... Liability Act (CERCLA), concerning the National Starch and Chemical Company Site located in Salisbury, Rowan..., identified by Docket ID No. EPA-RO4- SFUND-2011-0278 or Site name National Starch and Chemical...

  8. 78 FR 773 - Hartford Financial Services Group, Inc., Commercial/Actuarial/Information Delivery Services (IDS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    .../ Information Delivery Services (IDS)/Corporate & Financial Reporting Group, Hartford, CT; Notice of Affirmative... (IDS)/Corporate & Financial Reporting group, Hartford, Connecticut (The Hartford-IDS Group). The... applications for corporate, regulatory, and financial reporting. The group develops databases for...

  9. 4. BUNKER HILL LEAD SMELTER. VIEW IS FROM RIDGE ABOVE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. BUNKER HILL LEAD SMELTER. VIEW IS FROM RIDGE ABOVE GOVERNMENT GULCH LOOKING TO THE EAST. IN THE RIGHT MID GROUND, CARPENTER SHOP BUILDINGS AND FRAMING SHEDS ARE VISIBLE. THE BACKGROUND FACILITIES VISIBLE FROM L. TO R. ARE: SMELTER OFFICE, REFINERIES, SLAG FUMING STACKS, HIGH VELOCITY FLUE, BAG HOUSE, 200-FOOT STACK, AND 715-FOOT STACK. - Bunker Hill Lead Smelter, Bradley Rail Siding, Kellogg, Shoshone County, ID

  10. 416492 ORCID IDs and Counting: Uptake by the Astronomical Community

    NASA Astrophysics Data System (ADS)

    Holmquist, J.; Erdmann, C.; Damon, J.

    2015-04-01

    ORCID an acronym short for Open Researcher and Contributor ID is an international, interdisciplinary and community-driven effort to create and maintain a registry of persistent, unique identifiers for researchers and scholars. ORCID IDs are extremely important in the disambiguation of non-unique author names. They can also be embedded in key workflows, such as research profile maintenance, manuscript submissions and grant applications. Using several approaches to reach out to our users, we will report on ORCID ID uptake by the astronomical community.

  11. New security system for ID certificates in IT society

    NASA Astrophysics Data System (ADS)

    Nagashima, Hisato; Saito, Kazuharu

    2004-06-01

    This paper introduces a new security solution regarding security documents with secure unique information. Our newly proposed security measure enables outputting ID documents by commercially available printer. On this basis, a citizen can apply and accept his ID certificates to and from Issuing Authority via website. A unique gradational latent image emerges if a third party authenticates it under Infrared ray. The principle of this new measure lies in the complicated microstructure generated by our specially designed software. It is understood that its security feature based on secure software and wide applicability for commercially available printers show profound potentiality to construct new security system for ID documents in IT society.

  12. MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID, and Fragile X syndrome

    PubMed Central

    Siew, Wei-Hong; Tan, Kai-Leng; Babaei, Maryam Abbaspour; Cheah, Pike-See; Ling, King-Hwa

    2013-01-01

    Intellectual disability (ID) is one of the many features manifested in various genetic syndromes leading to deficits in cognitive function among affected individuals. ID is a feature affected by polygenes and multiple environmental factors. It leads to a broad spectrum of affected clinical and behavioral characteristics among patients. Until now, the causative mechanism of ID is unknown and the progression of the condition is poorly understood. Advancement in technology and research had identified various genetic abnormalities and defects as the potential cause of ID. However, the link between these abnormalities with ID is remained inconclusive and the roles of many newly discovered genetic components such as non-coding RNAs have not been thoroughly investigated. In this review, we aim to consolidate and assimilate the latest development and findings on a class of small non-coding RNAs known as microRNAs (miRNAs) involvement in ID development and progression with special focus on Down syndrome (DS) and X-linked ID (XLID) [including Fragile X syndrome (FXS)]. PMID:23596395

  13. 76 FR 78940 - Minidoka National Wildlife Refuge, Blaine, Cassia, Minidoka, and Power Counties, ID...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... by an expansive sea of sagebrush, identified as the high desert. In 1904 the Bureau of Reclamation... power. The Refuge is primarily an overlay refuge superimposed over Bureau of Reclamation lands...

  14. WATER QUALITY STATUS REPORT, OWYHEE RIVER, OWYHEE COUNTY, ID, 1976-1977.

    EPA Science Inventory

    A water quality survey of the Owyhee River in SW Idaho (17050104, 17050105, 17050106) was conducted from August 1976 to April 1977 by the State of Idaho, Department of Health and Welfare, Division of Environment. The survey was conducted to help determine if the Owyhee River in ...

  15. 77 FR 51561 - Notice of Temporary Restriction Order for Skinny Dipper Hot Springs, Boise County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ... Bureau of Land Management Notice of Temporary Restriction Order for Skinny Dipper Hot Springs, Boise...: This serves as notice of a sunset-to-sunrise recreational use restriction of Skinny Dipper Hot Springs... Hot Springs, and the public lands in Lot 3, Section 25, T. 9 N., R.3 E., Boise Meridian, Boise...

  16. 75 FR 1026 - Lower Orogrande Project, Clearwater National Forest, Clearwater County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-08

    ...The USDA, Forest Service, will prepare an Environmental Impact Statement (EIS) to disclose the environmental effects of improvements on watershed, vegetation, and wildlife habitat in the Lower Orogrande project area on the North Fork Ranger District of the Clearwater National Forest. The Lower Orogrande project area is located entirely within the Orogrande Creek watershed, which contains the......

  17. 77 FR 16556 - Kootenai National Wildlife Refuge, Boundary County, ID; Final Comprehensive Conservation Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ... a notice of intent in the Federal Register (74 FR 8102; February 23, 2009). We released the draft... Register (76 FR 48877; August 9, 2011). Kootenai NWR encompasses 2,774 acres along the lower Kootenai River... Administration Act. CCP Alternatives, Including Selected Alternative Our draft CCP/EA (76 FR 48877; August...

  18. GROUND WATER STUDY OF THE LOWER BOISE RIVER VALLEY, ADA AND CANYON COUNTIES, ID, 1996

    EPA Science Inventory

    From 24 Jul 95 through 24 Oct 95, a total of 335 ground water samples in the Lower Boise River Area (17050114) were collected by the USGS and the Division of Environmental Quality, Southwest Idaho Regional Office. This study is a continuation from the 1993-94 sampling in the Boi...

  19. 75 FR 8744 - Notice of Proposed Issuance of Recordable Disclaimer of Interest; Jerome County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... involving an 8.67 acre portion of Hunt Road adjacent to the Minidoka National Historic Site. This parcel of land, known as Tract No. 2 on the Minidoka National Historical Site Proposed Boundary Map 194/80,004... Tract No. 2 on the Minidoka National Historical Site Proposed Boundary Map, number 194/80,004...

  20. Rhizoctonia root rot resistance in experimental sugar beet cultivars in Twin Falls County, ID, 2012

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Rhizoctonia root rot continues to be a concerning problem in sugar beet production areas. To investigate resistance to this disease in 26 experimental sugar beet cultivars, field studies were conducted with three Rhizoctonia solani AG-2-2 IIIB strains. Based on means for the 26 cultivars, surface ...

  1. 78 FR 23952 - Notice of Temporary Closure on Public Lands in Elmore County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-23

    ... populations in the area. Approximately 2,938 acres of the burned area would be drill seeded with perennial... livestock from the burned area during recovery and seed establishment and provide soil stabilization....

  2. 77 FR 14417 - Notice of Temporary Closure on Public Lands in Gooding and Elmore Counties, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-09

    ... Boise District and Twin Falls District BLM offices. Maps of the affected area and other documents... Road, Twin Falls, Idaho 83301. Under the authority of Section 303(a) of the Federal Land Policy...

  3. Rhizoctonia root rot resistance in commercial sugar beet cultivars in Twin Falls County, ID, 2012

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Rhizoctonia root rot continues to be a concerning problem in sugar beet production areas. To investigate resistance to this disease in 26 commercial sugar beet cultivars, field studies were conducted with three Rhizoctonia solani AG-2-2 IIIB strains. Based on means for the 26 cultivars, surface ro...

  4. 77 FR 13072 - Salmon-Challis National Forest, Butte, Custer and Lemhi Counties, ID, Supplemental Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... Environmental Impact Statement to the 2009 Salmon- Challis National Forest Travel Planning and OHV Route...-Challis National Forest Travel Planning and OHV Route Designation Project FEIS and ROD as ordered by the... under the 2009 Travel Plan. Any motor vehicle route designation changes resulting from new...

  5. 77 FR 37702 - Grays Lake National Wildlife Refuge, Caribou and Bonneville Counties, ID; Comprehensive...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... challenges of climate change; and (14) How the refuge can most appropriately assess the efficacy of... alteration of Grays Lake's natural water levels has gradually changed the extent and composition of the marsh..., NWR). An Environmental Impact Statement (EIS) evaluating effects of various CCP alternatives will...

  6. 78 FR 16523 - Deer Flat National Wildlife Refuge, Canyon, Payette, Owyhee, and Washington Counties, ID, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ..., photography, jogging, bicycling, on- leash dog walking, and horseback riding. No additional trail or lake... youth waterfowl hunt would continue to be hosted in current waterfowl hunt zones. Gotts Point would... controlled waterfowl hunt (e.g., permit system or sign in/out) would be allowed only on the south side of...

  7. 77 FR 75654 - Notice of Temporary Closures on Public Lands in Owyhee County, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... and closed to all uses due to special resource concerns as a result of impacts from wildfire. DATES... roads and adjacent public lands are at risk from further damage by motorized vehicles. Road structure... potential for increased overland travel and resource damage. The road closures will eliminate possible...

  8. CONWAY GULCH, CANYON COUNTY, ID STATE AGRICULTURAL WATER QUALITY PROGRAM, 1988-1989

    EPA Science Inventory

    The Conway Gulch area (17050114) is a major source of pollutants effecting water quality and beneficial uses in Conway Gulch and the Lower Boise River. A pollution source and transport monitoring technique was used in evaluating water quality. The objective of this monitoring e...

  9. IDS Combined Solution improvements between ITRF2008 and ITRF2013

    NASA Astrophysics Data System (ADS)

    Moreaux, Guilhem; Lemoine, Frank; Willis, Pascal; Capdeville, Hugues; Otten, Michiel; Stepanek, Petr; Kuzin, Sergei; Ferrage, Pascale

    2015-04-01

    In the context of ITRF 2013, the IDS Combination Center delivered to IERS weekly combined SINEX files from early January 1993 to late August 2014. These SINEX files which contain DORIS stations positions/velocities and Earth orientation parameters from DORIS data are based on the latest series of all of the 6 IDS Analysis Centers. The primary objective of this study is to present latest results from the DORIS contribution to ITRF2013. Then, comparisons with IDS contribution to ITRF2008 will address benefits of including both South Atlantic Anomaly corrected data and new DORIS missions (e.g. Jason-1, Jason-2, Cryosat-2) in the IDS combination. These comparisons will also emphasize application of DORIS ground antennas phase laws in the data processing and improved modeling of DORIS ground beacon frequency variations.

  10. Genetics Experts Unite to I.D. Unknown Katrina Victims

    MedlinePLUS

    ... NIH Genetics Experts Unite to I.D. Unknown Katrina Victims Past Issues / Summer 2006 Table of Contents ... than 70 bodies in the aftermath of Hurricane Katrina. "What we are discovering in the recent Advances ...

  11. Security analysis for biometric data in ID documents

    NASA Astrophysics Data System (ADS)

    Schimke, Sascha; Kiltz, Stefan; Vielhauer, Claus; Kalker, Ton

    2005-03-01

    In this paper we analyze chances and challenges with respect to the security of using biometrics in ID documents. We identify goals for ID documents, set by national and international authorities, and discuss the degree of security, which is obtainable with the inclusion of biometric into documents like passports. Starting from classical techniques for manual authentication of ID card holders, we expand our view towards automatic methods based on biometrics. We do so by reviewing different human biometric attributes by modality, as well as by discussing possible techniques for storing and handling the particular biometric data on the document. Further, we explore possible vulnerabilities of potential biometric passport systems. Based on the findings of that discussion we will expand upon two exemplary approaches for including digital biometric data in the context of ID documents and present potential risks attack scenarios along with technical aspects such as capacity and robustness.

  12. Id Proteins Regulate Capillary Repair and Perivascular Cell Proliferation following Ischemia-Reperfusion Injury

    PubMed Central

    Lee, David; Shenoy, Shantheri; Nigatu, Yezina; Plotkin, Matt

    2014-01-01

    Acute kidney injury (AKI) results in microvascular damage that if not normally repaired, may lead to fibrosis. The Id1 and 3 proteins have a critical role in promoting angiogenesis during development, tumor growth and wound repair by functioning as dominant negative regulators of bHLH transcription factors. The goal of this study was to determine if Id proteins regulate microvascular repair and remodeling and if increased Id1 expression results in decreased capillary loss following AKI. The effect of changes in Id expression in vivo was examined using Id1?/?, Id3RFP/+ (Id1/Id3 KO) and Tek (Tie2)-rtTA, TRE-lacz/TRE Id1 (TRE Id1) mice with doxycycline inducible endothelial Id1 and ?-galactosidase expression. Id1 and 3 were co-localized in endothelial cells in normal adult kidneys and protein levels were increased at day 3 following ischemia-reperfusion injury (IRI) and contralateral nephrectomy. Id1/Id3 KO mice had decreased baseline capillary density and pericyte coverage and increased tubular damage following IRI but decreased interstitial cell proliferation and fibrosis compared with WT littermates. No compensatory increase in kidney size occurred in KO mice resulting in increased creatinine compared with WT and TRE Id1 mice. TRE Id1 mice had no capillary rarefaction within 1 week following IRI in comparison with WT littermates. TRE Id1 mice had increased proliferation of PDGFR? positive interstitial cells and medullary collagen deposition and developed capillary rarefaction and albuminuria at later time points. These differences were associated with increased Angiopoietin 1 (Ang1) and decreased Ang2 expression in TRE Id1 mice. Examination of gene expression in microvascular cells isolated from WT, Id1/Id3 KO and TRE Id1 mice showed increased Ang1 and ?SMA in Id1 overexpressing cells and decreased pericyte markers in cells from KO mice. These results suggest that increased Id levels following AKI result in microvascular remodeling associated with increased fibrosis. PMID:24516656

  13. BioID Identification of Lamin-Associated Proteins.

    PubMed

    Mehus, Aaron A; Anderson, Ruthellen H; Roux, Kyle J

    2016-01-01

    A- and B-type lamins support the nuclear envelope, contribute to heterochromatin organization, and regulate a myriad of nuclear processes. The mechanisms by which lamins function in different cell types and the mechanisms by which lamin mutations cause over a dozen human diseases (laminopathies) remain unclear. The identification of proteins associated with lamins is likely to provide fundamental insight into these mechanisms. BioID (proximity-dependent biotin identification) is a unique and powerful method for identifying protein-protein and proximity-based interactions in living cells. BioID utilizes a mutant biotin ligase from bacteria that is fused to a protein of interest (bait). When expressed in living cells and stimulated with excess biotin, this BioID-fusion protein promiscuously biotinylates directly interacting and vicinal endogenous proteins. Following biotin-affinity capture, the biotinylated proteins can be identified using mass spectrometry. BioID thus enables screening for physiologically relevant protein associations that occur over time in living cells. BioID is applicable to insoluble proteins such as lamins that are often refractory to study by other methods and can identify weak and/or transient interactions. We discuss the use of BioID to elucidate novel lamin-interacting proteins and its applications in a broad range of biological systems, and provide detailed protocols to guide new applications. PMID:26778550

  14. Transcriptional regulator Id2 mediates CD8+ T cell immunity.

    PubMed

    Cannarile, Michael A; Lind, Nicholas A; Rivera, Richard; Sheridan, Alison D; Camfield, Kristin A; Wu, Bei Bei; Cheung, Kitty P; Ding, Zhaoqing; Goldrath, Ananda W

    2006-12-01

    Transcriptional programs that initiate and sustain the proliferation, differentiation and survival of CD8(+) T cells during immune responses are not completely understood. Here we show that inhibitor of DNA binding 2 (Id2), an antagonist of E protein transcription factors, was upregulated in CD8(+) T cells during infection and that expression of Id2 was maintained in memory CD8(+) T cells. Although Id2-deficient naive CD8(+) T cells recognized antigen and proliferated normally early after infection, effector CD8(+) T cells did not accumulate because the cells were highly susceptible to apoptosis. Id2-deficient CD8(+) T cells responding to infection had changes in the expression of genes that influence survival and had altered memory formation. Our data emphasize the importance of Id2 in regulating gene expression by CD8(+) T cells and the magnitude of effector responses, suggesting a mechanism involving Id protein- and E protein-mediated survival and differentiation of mature T cells. PMID:17086188

  15. Bathymetry and capacity of Blackfoot Reservoir, Caribou County, Idaho, 2011

    USGS Publications Warehouse

    Wood, Molly S.; Skinner, Kenneth D.; Fosness, Ryan L.

    2012-01-01

    The U.S. Geological Survey (USGS), in cooperation with the Shoshone-Bannock Tribes, surveyed the bathymetry and selected above-water sections of Blackfoot Reservoir, Caribou County, Idaho, in 2011. Reservoir operators manage releases from Government Dam on Blackfoot Reservoir based on a stage-capacity relation developed about the time of dam construction in the early 1900s. Reservoir operation directly affects the amount of water that is available for irrigation of agricultural land on the Fort Hall Indian Reservation and surrounding areas. The USGS surveyed the below-water sections of the reservoir using a multibeam echosounder and real-time kinematic global positioning system (RTK-GPS) equipment at full reservoir pool in June 2011, covering elevations from 6,090 to 6,119 feet (ft) above the North American Vertical Datum of 1988 (NAVD 88). The USGS used data from a light detection and ranging (LiDAR) survey performed in 2000 to map reservoir bathymetry from 6,116 to 6,124 ft NAVD 88, which were mostly in depths too shallow to measure with the multibeam echosounder, and most of the above-water section of the reservoir (above 6,124 ft NAVD 88). Selected points and bank erosional features were surveyed by the USGS using RTK-GPS and a total station at low reservoir pool in September 2011 to supplement and verify the LiDAR data. The stage-capacity relation was revised and presented in a tabular format. The datasets show a 2.0-percent decrease in capacity from the original survey, due to sedimentation or differences in accuracy between surveys. A 1.3-percent error also was detected in the previously used capacity table and measured water-level elevation because of questionable reference elevation at monitoring stations near Government Dam. Reservoir capacity in 2011 at design maximum pool of 6,124 ft above NAVD 88 was 333,500 acre-ft.

  16. The Self- and Other-Deception Questionnaires-Intellectual Disabilities (SDQ-ID and ODQ-ID): component analysis and reliability.

    PubMed

    Jobson, Laura; Stanbury, Alexandra; Langdon, Peter E

    2013-10-01

    The objectives of this research were to: (1) investigate the component structure and psychometric properties of the Self- and Other-Deception Questionnaires-Intellectual Disabilities (SDQ-ID and ODQ-ID), (2) examine the relationship between social desirability and IQ, and (3) compare social desirability scores of those with intellectual disabilities (IDs) and a history of criminal offending to the social desirability scores of participants with IDs and those without IDs and no such history, controlling for general intellectual functioning. Men with mild to borderline IDs detained within medium secure inpatient forensic mental health services (N=40) completed the SDQ-ID and ODQ-ID at Time 1 and then two-weeks later at Time 2. Data for the men with and without IDs and no known criminal offending history were taken from a previous study (N=60). Following exploratory Principal Components Analysis, the number of questionnaire items were reduced, and a two-factor structure was found for the SDQ-ID which was labelled: (1) Positive Self Representation and (2) Denial of Intrusive Thoughts. A two-factor structure was also found for the ODQ-ID and these two factors were labelled: (1) Denial of Negative Social Interaction and (2) Untrustworthiness. Both the SDQ-ID and ODQ-ID had acceptable internal consistency and test-retest reliability. Fifteen percent of the variance in SDQ-ID scores was explained by Full Scale IQ, while 21% of the variance in ODQ-ID scores was explained by Full Scale IQ. Between group comparisons controlling for intelligence did not yield any significant differences. The shortened SDQ-ID and ODQ-ID have promising psychometric properties, and their component structures appear robust. Differences between men with and without IDs on these two measures of social desirability can be accounted for by differences in general intellectual functioning. PMID:23962604

  17. 3-D RESERVOIR AND STOCHASTIC FRACTURE NETWORK MODELING FOR ENHANCED OIL RECOVERY, CIRCLE RIDGE PHOSPHORIA/TENSLEEP RESERVOIR, WIND RIVER RESERVATION, ARAPAHO AND SHOSHONE TRIBES, WYOMING

    SciTech Connect

    Paul La Pointe; Jan Hermanson; Robert Parney; Thorsten Eiben; Mike Dunleavy; Ken Steele; John Whitney; Darrell Eubanks; Roger Straub

    2002-11-18

    This report describes the results made in fulfillment of contract DE-FG26-00BC15190, ''3-D Reservoir and Stochastic Fracture Network Modeling for Enhanced Oil Recovery, Circle Ridge Phosphoria/Tensleep Reservoir, Wind River Reservation, Arapaho and Shoshone Tribes, Wyoming''. The goal of this project is to improve the recovery of oil from the Tensleep and Phosphoria Formations in Circle Ridge Oilfield, located on the Wind River Reservation in Wyoming, through an innovative integration of matrix characterization, structural reconstruction, and the characterization of the fracturing in the reservoir through the use of discrete fracture network models. Fields in which natural fractures dominate reservoir permeability, such as the Circle Ridge Field, often experience sub-optimal recovery when recovery processes are designed and implemented that do not take advantage of the fracture systems. For example, a conventional waterflood in a main structural block of the Field was implemented and later suspended due to unattractive results. It is estimated that somewhere less than 20% of the OOIP in the Circle Ridge Field have been recovered after more than 50 years' production. Marathon Oil Company identified the Circle Ridge Field as an attractive candidate for several advanced IOR processes that explicitly take advantage of the natural fracture system. These processes require knowledge of the distribution of matrix porosity, permeability and oil saturations; and understanding of where fracturing is likely to be well-developed or poorly developed; how the fracturing may compartmentalize the reservoir; and how smaller, relatively untested subthrust fault blocks may be connected to the main overthrust block. For this reason, the project focused on improving knowledge of the matrix properties, the fault block architecture and to develop a model that could be used to predict fracture intensity, orientation and fluid flow/connectivity properties. Knowledge of matrix properties was greatly extended by calibrating wireline logs from 113 wells with incomplete or older-vintage logging suites to wells with a full suite of modern logs. The model for the fault block architecture was derived by 3D palinspastic reconstruction. This involved field work to construct three new cross-sections at key areas in the Field; creation of horizon and fault surface maps from well penetrations and tops; and numerical modeling to derive the geometry, chronology, fault movement and folding history of the Field through a 3D restoration of the reservoir units to their original undeformed state. The methodology for predicting fracture intensity and orientation variations throughout the Field was accomplished by gathering outcrop and subsurface image log fracture data, and comparing it to the strain field produced by the various folding and faulting events determined through the 3D palinspastic reconstruction. It was found that the strains produced during the initial folding of the Tensleep and Phosphoria Formations corresponded well without both the orientations and relative fracture intensity measured in outcrop and in the subsurface. The results have led to a 15% to 20% increase in estimated matrix pore volume, and to the plan to drill two horizontal drain holes located and oriented based on the modeling results. Marathon Oil is also evaluating alternative tertiary recovery processes based on the quantitative 3D integrated reservoir model.

  18. Annual audits of IDS risk contract settlements improve payment accuracy.

    PubMed

    Pearce, J W

    1999-12-01

    Integrated delivery systems (IDSs) should conduct annual audits of payers' settlements under risk contracts to verify that the payer attributed the appropriate amounts of revenue and charged the appropriate claims expenses to the IDS. In particular, IDSs should verify that payers calculated revenues and expenses based on consistent member counts and that the determined commercial revenue was based on the actual premiums paid. IDSs also should determine whether payers have used appropriate demographic factors and countywide rates as a basis for determining Medicare revenue, charged the IDS for claims only for valid members, paid capitated providers the correct capitation amounts, and used appropriate historical data to estimate the amounts of incurred-but-not-reported claims attributed to the IDS. PMID:11066693

  19. High secure authentication by optical multifactor ID tags

    NASA Astrophysics Data System (ADS)

    Milln, Mara S.; Prez-Cabr, Elisabet; Javidi, Bahram

    2006-09-01

    Multifactor encryption-authentication technique reinforces optical security by allowing the simultaneous AND-verification of more than one primary image. The method involves double random-phase encoding, fully phase-based encryption and a combined nonlinear JTC and a classical 4f-correlator for simultaneous recognition and authentication of multiple images. The encoded signal fulfils the general requirements of invisible content, extreme difficulty in counterfeiting and real-time automatic verification. Four reference images, double-phase encoded and encrypted in an ID tag are compared with the input images obtained in situ from the person or the vehicle whose authentication is wanted and from a database. Optical ID tags are satisfactory items to achieve remote and real-time optical authentication. On the one hand, effort has been focused on the tag design to provide a positive identification even though the receiver captured the ID tag under some distortion. On the other hand, demands on increasing security require ciphering the information prior to include it in the ID tag. A recognition step based on the correlation between the retrieved signature and a stored reference determines the authentication or rejection of the object under surveillance. In this work, we combine optical ID tags with the multifactor authentication procedure. Instead of basing the identification on a unique signature or piece of information, our goal is to authenticate a given person, object, or vehicle, by the simultaneous recognition of several factors. Some of them are intrinsic to the person and vehicle under control. Other factors, act as keys of the authentication step. The information of the whole set of factors is included in the ID tag. Remote identification of all factors is achieved. Such a system is proposed to control the access of people and vehicles in restricted areas, where the demand of security is high.

  20. SULFUR DIOXIDE SOURCES IN WA, OR, AND ID

    EPA Science Inventory

    This map shows industrial plants which emit 100 tons/year or more of sulfur dioxide (SO2) in Idaho, Oregon, and Washington. The SO2 sources are plotted on a background map of cities and county boundaries. Data Sources: SO2 Sites: U.S. EPA AIRS System, County Outlines: USGS, Nat...

  1. County Staff or Area Staff?

    ERIC Educational Resources Information Center

    McIntyre, William J.

    1970-01-01

    McIntryre explores the questions of county-based extention and increased specialization in Indiana. He compares the multi-county with individual county systems using variables including clientele's reactions to the two systems. (NL)

  2. Hancock County Awards Gala

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Gene Goldman (left), deputy director of NASA's John C. Stennis Space Center, accepts an Award of Excellence from Jack Zink, executive director of the Hancock County Port and Harbor Commission, during the 2008 Annual Hancock County Awards Gala. The Award of Excellence was presented to recognize Stennis Space Center's contribution to NASA's 50 years of excellence in space exploration.

  3. Inhibitor of differentiation-4 (Id4) stimulates pigmentation in melanoma leading to histiocyte infiltration.

    PubMed

    DiVito, Kyle A; Trabosh, Valerie A; Chen, You-Shin; Simbulan-Rosenthal, Cynthia M; Rosenthal, Dean S

    2015-02-01

    TGF-? and the inhibitors of differentiation (Id) are linked. Smad7 and other TGF-? inhibitors can potently suppress melanomagenesis; however, little work examining Ids has been reported in melanoma, particularly for Id4. Here, we report that Id4, but not Id2 or Id3 expression, surprisingly, activated robust melanin production in xenografts of previously amelanotic (lacking pigment) 1205Lu/Smad7 (S7) cells. Fontana-Masson stain and de-novo expression of MART-1 and tyrosinase proteins confirmed melanin production. Additionally, pigment-laden CD163+ mouse histiocytes with areas of extensive necrosis were found throughout S7/Id4 tumors, but not in parental 1205Lu, S7/Id2 or S7Id3-derived tumors. Mechanistic investigation revealed increased nuclear M-microphthalmia-associated transcription factor (MITF) and MART-1 promoter activation following Id4 expression in 1205Lu and WM852 melanoma cells, suggesting broader implications for Id4 in melanin synthesis. In human tumors, melanin colocalized with Id4 expression establishing a correlation. Current chemotherapeutics for melanoma are only marginally effective. Immunotherapy provides the most promise, yet the role of innate immunity is poorly understood. Here, TGF-? suppression followed by Id4 expression results in extensive melanin synthesis and robust histiocyte recruitment following tumorigenesis, a novel role for Id4. Our results suggest that TGF-? suppression coupled with pigment overproduction triggers an innate immune response resulting in tumor necrosis. PMID:25363621

  4. Comparison of Perinatal Risk Factors Associated with Autism Spectrum Disorder (ASD), Intellectual Disability (ID), and Co-occurring ASD and ID.

    PubMed

    Schieve, Laura A; Clayton, Heather B; Durkin, Maureen S; Wingate, Martha S; Drews-Botsch, Carolyn

    2015-08-01

    While studies report associations between perinatal outcomes and both autism spectrum disorder (ASD) and intellectual disability (ID), there has been little study of ASD with versus without co-occurring ID. We compared perinatal risk factors among 7547 children in the 2006-2010 Autism and Developmental Disability Monitoring Network classified as having ASD + ID, ASD only, and ID only. Children in all three groups had higher rates of preterm birth (PTB), low birth weight, small-for-gestational-age, and low Apgar score than expected based on the US birth cohort adjusted for key socio-demographic factors. Associations with most factors, especially PTB, were stronger for children with ID only than children with ASD + ID or ASD only. Associations were similar for children with ASD + ID and ASD only. PMID:25739693

  5. 75 FR 61610 - Modification of Class E Airspace; Arco, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... Federal Register a notice of proposed rulemaking to amend controlled airspace at Arco, ID (75 FR 41773... U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of...

  6. 77 FR 55688 - Amendment of Class E Airspace; Boise, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... E airspace designated as an extension at Boise Air Terminal, Boise, ID (77 FR 38552). Interested... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR 71.1... FR 6026). Interested parties were invited to participate in this rulemaking effort by...

  7. A Synergetic Model for Building an Intelligent Documentation System (IDS).

    ERIC Educational Resources Information Center

    Emdad, Ali

    1990-01-01

    Presents a conceptual framework for building an intelligent documentation system (IDS) for computer software by integrating hypermedia and expert systems technologies. The need for online computer documentation for end-users is discussed, and elements of the synergetic model are described, including knowledge representation, the hypermedia

  8. Blueprints for Complex Learning: The 4C/ID-Model.

    ERIC Educational Resources Information Center

    van Merrienboer, Jeroen J. G.; Clark, Richard E.; de Croock, Marcel B. M.

    2002-01-01

    Describes the four-component instructional design system (4C/ID-model) developed for the design of training programs for complex skills. Discusses the structure of training blueprints for complex learning and associated instructional methods, focusing on learning tasks, supportive information, just-in-time information, and part-task practice.

  9. Enabling OpenID Authentication for VO-integrated Portals

    NASA Astrophysics Data System (ADS)

    Plante, R.; Yekkirala, V.; Baker, W.

    2012-09-01

    To support interoperating services that share proprietary data and other user-specific information, the VAO Project provides login services for browser-based portals built on the open standard, OpenID. To help portal developers take advantage of this service, we have developed a downloadable toolkit for integrating OpenID single sign-on support into any portal. This toolkit provides APIs in a few languages commonly used on the server-side as well as a command-line version for use in any language. In addition to describing how to use this toolkit, we also discuss the general VAO framework for single sign-on. While a portal may, if it wishes, support any OpenID provider, the VAO service provides a few extra features to support VO interoperability. This includes a portal's ability to retrieve (with the user's permission) an X.509 certificate representing the authenticated user so that the portal can access other restricted services on the user's behalf. Other standard features of OpenID allow portals to request other information about the user; this feature will be used in the future for sharing information about a user's group membership to enable sharing within a group of collaborating scientists.

  10. 75 FR 12974 - Establishment of Class E Airspace; Hailey, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ... Register a notice of proposed rulemaking to establish additional controlled airspace at Hailey, ID (74 FR... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E. O. 10854, 24 FR 9565,...

  11. 78 FR 65555 - Establishment of Class E Airspace; Salmon, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... proposed rulemaking (NPRM) to establish controlled airspace at Salmon, ID (78 FR 45478). Interested parties...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  12. 76 FR 70865 - Modification of Class E Airspace; Driggs, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ...), 40103, 40113, 40120; E. O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The... proposed rulemaking to modify controlled airspace at Driggs, ID (76 FR 56356). Interested parties were... a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26,...

  13. An Application of Decision Tree Based on ID3

    NASA Astrophysics Data System (ADS)

    Xiaohu, Wang; Lele, Wang; Nianfeng, Li

    This article deals with the application of classical decision tree ID3 of the data mining in a certain site data. It constitutes a decision tree based on information gain and thus produces some useful purchasing behavior rules. It also proves that the decision tree has a wide applicable future in the sale field on site.

  14. Three combat ID systems for the dismounted soldier

    NASA Astrophysics Data System (ADS)

    Brenner, Charles; Sherman, Kevin

    1998-08-01

    Three different Combat ID systems for the Dismounted Soldier are described and areas of commonality and differences are noted. CIDDS (Combat ID for Dismounted Soldiers) is a complete Stand-Alone system for non-Land Warrior equipped soldier's. To the weapon, it adds a laser interrogator that produces a Multiple Integrated Laser Engagement Systems (MILES) like pulse coded waveform and a RF receiver. To the soldiers helmet, it adds four laser detectors and an RF transmitter that uses frequency diversity and TDMA to respond. Land Warrior Combat ID, being developed on the Force XXI Land Warrior program, adds a similar laser interrogator to the weapon but uses existing laser detectors on the helmet. Detection of a laser interrogation automatically causes a RF reply via the Land Warrior Soldier Radio (LWSR) that operates in the 1.8 GHz frequency range using a TDMA format. Helicopter to Dismounted Soldier ID (HDSID) uses the SIngle Channel Ground Airborne Radio System (SINCGARS) SIP+ radios, operating in the 30 to 88 MHz band, for both interrogation and reply. The SINCGARS SIP+ ground receivers interrupt normal voice or data transmission/reception every second for a very short interval and switch to receive on the 'Interrogation' net. Up to three helicopters can make interrogations during any one-second interval. CIDDS and Land Warrior CID are presently in development, while HDSID is a recently completed study.

  15. Evaluation of red blood cell and platelet antigen genotyping platforms (ID CORE XT/ID HPA XT) in routine clinical practice

    PubMed Central

    Finning, Kirstin; Bhandari, Radhika; Sellers, Fiona; Revelli, Nicoletta; Villa, Maria Antonietta; Muñiz-Díaz, Eduardo; Nogués, Núria

    2016-01-01

    Background High-throughput genotyping platforms enable simultaneous analysis of multiple polymorphisms for blood group typing. BLOODchip® ID is a genotyping platform based on Luminex® xMAP technology for simultaneous determination of 37 red blood cell (RBC) antigens (ID CORE XT) and 18 human platelet antigens (HPA) (ID HPA XT) using the BIDS XT software. Materials and methods In this international multicentre study, the performance of ID CORE XT and ID HPA XT, using the centres’ current genotyping methods as the reference for comparison, and the usability and practicality of these systems, were evaluated under working laboratory conditions. DNA was extracted from whole blood in EDTA with Qiagen methodologies. Ninety-six previously phenotyped/genotyped samples were processed per assay: 87 testing samples plus five positive controls and four negative controls. Results Results were available for 519 samples: 258 with ID CORE XT and 261 with ID HPA XT. There were three “no calls” that were either caused by human error or resolved after repeating the test. Agreement between the tests and reference methods was 99.94% for ID CORE XT (9,540/9,546 antigens determined) and 100% for ID HPA XT (all 4,698 alleles determined). There were six discrepancies in antigen results in five RBC samples, four of which (in VS, N, S and Doa) could not be investigated due to lack of sufficient sample to perform additional tests and two of which (in S and C) were resolved in favour of ID CORE XT (100% accuracy). The total hands-on time was 28–41 minutes for a batch of 16 samples. Compared with the reference platforms, ID CORE XT and ID HPA XT were considered simpler to use and had shorter processing times. Discussion ID CORE XT and ID HPA XT genotyping platforms for RBC and platelet systems were accurate and user-friendly in working laboratory settings. PMID:26674823

  16. County by County in Ohio Genealogy.

    ERIC Educational Resources Information Center

    Khouw, Petta; And Others

    This comprehensive sourcebook and bibliography lists Ohio genealogical materials available at the State Library of Ohio for each county in the state. It serves as a guide to Ohio genealogical resources, including 14,000 volumes and 15,000 microforms in the non-circulating genealogy collection. The library's genealogy collection consists of a broad…

  17. Subgroups associated with lower physical fitness in older adults with ID: results of the HA-ID study.

    PubMed

    Hilgenkamp, Thessa I M; van Wijck, Ruud; Evenhuis, Heleen M

    2014-02-01

    Although physical fitness is generally very low in older adults with intellectual disabilities (ID), levels may differ across subgroups. It is important to identify which subgroups need to be targeted specifically in physical activity and fitness interventions and reference values. Physical fitness was measured with box-and-block-test, response-time-test, Berg-balance-scale, walking speed, grip strength, 30s-chair-stand, 10 m incremental-shuttle-walking test and the extended modified-back-saver-sit-and-reach-test in a large sample of older adults with ID (n=1050), and subgroups associated with lower physical fitness levels were identified applying multivariate linear regression analyses. Both fixed personal characteristics such as being older, being female, having more severe ID and having Down syndrome and modifiable or preventable factors such as physical activity levels, mobility impairments and a need of more intensive care, are independently associated with lower levels of multiple physical fitness components. This first study identifies subgroups of older adults with ID which require adapted reference values, and subgroups that need to be specifically targeted in fitness promotion programs. PMID:24361812

  18. Biolog(TM) ID as compared to 16S ribosomal RNA ID for environmental isolates from the deep subsurface

    SciTech Connect

    McKinsey, P.C.

    2000-05-05

    The U.S. Dept of Energy (DOE) Subsurface Microbial Culture Collection (SMCC) contains nearly 10,000 strains of microorganisms isolated from terrestrial subsurface environments. Many of the aerobic, gram-negative, chemoheterotrophs isolated from the DOE Savannah River Site (SRS) have previously been identified by phylogenetic analysis of 16S ribosomal RNA (rRNA) gene nucleotide sequences. These SMCC isolates are currently being examined using Biolog GN Microplates and the Biolog Microstation System in order to gain knowledge of their metabolic capabilities and to compare Biolog IDs with 16S IDs. To accommodate the particular needs of these subsurface isolates, which are often incapable of growing under high-nutrient conditions, Biolog's recommendations for inoculating isolates into Biolog GN Microplates have been altered. The isolates are grown on low nutrient media, sodium thioglycolate (3mM) is added to the culture media to inhibit capsule formation, and a low density of bacteria is inoculated into the microplate. Using these altered inoculation criteria, 60 percent of these SMCC isolates have a Biolog genus ID that matches the 16S rRNA ID. These results indicate that the Biolog System can be a good means of identifying unusual environmental isolates, even when recommended inoculation procedures are altered to accommodate particular isolate needs.

  19. Elevated Id2 expression results in precocious neural stem cell depletion and abnormal brain development.

    PubMed

    Park, Hee Jung; Hong, Mingi; Bronson, Roderick T; Israel, Mark A; Frankel, Wayne N; Yun, Kyuson

    2013-05-01

    Id2 is a helix-loop-helix transcription factor essential for normal development, and its expression is dysregulated in many human neurological conditions. Although it is speculated that elevated Id2 levels contribute to the pathogenesis of these disorders, it is unknown whether dysregulated Id2 expression is sufficient to perturb normal brain development or function. Here, we show that mice with elevated Id2 expression during embryonic stages develop microcephaly, and that females in particular are prone to generalized tonic-clonic seizures. Analyses of Id2 transgenic brains indicate that Id2 activity is highly cell context specific: elevated Id2 expression in naive neural stem cells (NSCs) in early neuroepithelium induces apoptosis and loss of NSCs and intermediate progenitors. Activation of Id2 in maturing neuroepithelium results in less severe phenotypes and is accompanied by elevation of G1 cyclin expression and p53 target gene expression. In contrast, activation of Id2 in committed intermediate progenitors has no significant phenotype. Functional analysis with Id2-overexpressing and Id2-null NSCs shows that Id2 negatively regulates NSC self-renewal in vivo, in contrast to previous cell culture experiments. Deletion of p53 function from Id2-transgenic brains rescues apoptosis and results in increased incidence of brain tumors. Furthermore, Id2 overexpression normalizes the increased self-renewal of p53-null NSCs, suggesting that Id2 activates and modulates the p53 pathway in NSCs. Together, these data suggest that elevated Id2 expression in embryonic brains can cause deregulated NSC self-renewal, differentiation, and survival that manifest in multiple neurological outcomes in mature brains, including microcephaly, seizures, and brain tumors. PMID:23390122

  20. UVB upregulates the bax promoter in immortalized human keratinocytes via ROS induction of Id3*

    PubMed Central

    Trabosh, Valerie Anne; Daher, Ahmad; Amin, Karishma; Simbulan-Rosenthal, Cynthia M.; Rosenthal, Dean S.

    2009-01-01

    Id3 belongs to the Inhibitor of differentiation family of HLH transcription factors, important in proliferation, differentiation, and apoptosis. We showed that Id3, but not Id2 or Id1, mediates the UVB-sensitization of immortalized keratinocytes by inducing caspase 9-dependent apoptosis. In the current study, quantitative PCR analysis revealed a time-dependent increase in Id3 mRNA induced by UVB, dependent on reactive oxygen species. UVB upregulated promoter activity of Id3, but not Id2, at early time points, as shown by reporter assays, and also stabilized Id3 mRNA, increasing its half-life from 10 to ~60 minutes. We next examined downstream events related to UVB-induced Id3 upregulation and investigated the effects of UVB or ectopic expression of Id3 on bax promoter activity. Regulatory elements in the bax promoter that mediate transcriptional activation by UVB and Id3, in the absence of p53, were identified. Bax promoter deletion analysis revealed that transcriptional activation by UVB involves a 738-bp region upstream from the transcription start site of bax. Mimicking the effects of UVB, ectopic expression of Id3 also upregulated bax mRNA and activated this 738-bp fragment. Mutational analysis of the transcription binding sites further showed that point mutations of the E-box region found in the 738-bp fragment, but not in a 174-bp fragment, completely abolished Id3- and UVB-inducible bax promoter activity, thus confirming the importance of Id3 and UVB-mediated Id3 upregulation in activating the bax promoter. These results suggest a mechanism whereby ROS upregulation of Id3 relieves repression of bax via E-box-binding factors. PMID:19054058

  1. Status and evolution of the ESRF beamline ID19

    SciTech Connect

    Weitkamp, Timm; Tafforeau, Paul; Boller, Elodie; Cloetens, Peter; Valade, Jean-Paul; Bernard, Pascal; Baruchel, Jose; Peyrin, Francoise; Helfen, Lukas

    2010-04-06

    The ESRF synchrotron beamline ID19, dedicated to full-field parallel-beam imaging techniques such as phase-contrast and absorption microtomography and X-ray topography, is one of the most versatile instruments of its kind. This paper presents key characteristics of ID19 in its present form, names examples for research and development performed on the beamline, and outlines the plans for an upgrade on the beamline in coming years, to adapt to the growing needs of the user community. The technical goals envisioned include an increase in available beam size and maximum photon energy, and a substantial increase in flux density for applications using beams of small and intermediate size.

  2. 77 FR 37696 - Agency Information Collection Activities: Importer ID Input Record

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Importer ID Input... other Federal agencies to comment on an information collection requirement concerning the Importer ID... concerning the following information collection: Title: Importer ID Input Record. OMB Number: 1651-0064....

  3. Picture This: How to Establish an Effective School ID Card Program

    ERIC Educational Resources Information Center

    Finkelstein, David

    2013-01-01

    Most school districts do not have an ID card policy that everyone knows and follows, yet. many school districts are implementing ID card programs to address concerns about safety, efficiency, and convenience. A well-thought-out ID card program leads to greater security and smoother operations throughout the school and should thus be a priority.

  4. Picture This: How to Establish an Effective School ID Card Program

    ERIC Educational Resources Information Center

    Finkelstein, David

    2013-01-01

    Most school districts do not have an ID card policy that everyone knows and follows, yet. many school districts are implementing ID card programs to address concerns about safety, efficiency, and convenience. A well-thought-out ID card program leads to greater security and smoother operations throughout the school and should thus be a priority.…

  5. A Role for Id2 in Regulating Photic Entrainment of the Mammalian Circadian System

    PubMed Central

    Duffield, Giles E.; Watson, Nathan P.; Mantani, Akio; Peirson, Stuart N.; Robles-Murguia, Maricela; Loros, Jennifer J.; Israel, Mark A.; Dunlap, Jay C.

    2009-01-01

    Summary Inhibitor of DNA binding genes (Id1Id4) encode helix-loop-helix (HLH) transcriptional repressors associated with development and tumorigenesis [1, 2], but little is known concerning the function(s) of these genes in normal adult animals. Id2 was identified in DNA microarray screens for rhythmically expressed genes [35], and further analysis revealed a circadian pattern of expression of all four Id genes in multiple tissues including the suprachiasmatic nucleus. To explore an invivo function, we generated and characterized deletion mutations of Id2 and of Id4. Id2?/? mice exhibit abnormally rapid entrainment and an increase in the magnitude of the phase shift of the pacemaker. A significant proportion of mice also exhibit disrupted rhythms when maintained under constant darkness. Conversely, Id4?/? mice did not exhibit a noticeable circadian phenotype. In vitro studies using an mPer1 and an AVP promoter reporter revealed the potential for ID1, ID2, and ID3 proteins to interact with the canonical basic HLH clock proteins BMAL1 and CLOCK. These data suggest that the Id genes may be important for entrainment and operation of the mammalian circadian system, potentially acting through BMAL1 and CLOCK targets. PMID:19217292

  6. 76 FR 28306 - Amendment of Class D and Class E Airspace; Idaho Falls, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D and Class E Airspace; Idaho Falls, ID... existing Class D and Class E airspace at Idaho Falls, ID, by changing the name of the airport to Idaho... Federal Register a notice of proposed rulemaking to amend controlled airspace at Idaho Falls, ID (76...

  7. 32 CFR 161.8 - ID card life-cycle roles and responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false ID card life-cycle roles and responsibilities. 161.8 Section 161.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY IDENTIFICATION (ID) CARDS FOR MEMBERS OF THE UNIFORMED SERVICES, THEIR DEPENDENTS, AND OTHER ELIGIBLE INDIVIDUALS DoD Identification (ID) Cards:...

  8. IDing Innate and Innate-like Lymphoid Cells

    PubMed Central

    Verykokakis, Mihalis; Zook, Erin C.; Kee, Barbara L.

    2014-01-01

    Summary The immune system can be divided into innate and adaptive components that differ in their rate and mode of cellular activation, with innate immune cells being the first responders to invading pathogens. Recent advances in the identification and characterization of innate lymphoid cells have revealed reiterative developmental programs that result in cells with effector fates that parallel those of adaptive lymphoid cells and are tailored to effectively eliminate a broad spectrum of pathogenic challenges. However, activation of these cells can also be associated with pathologies such as autoimmune disease. One major distinction between innate and adaptive immune system cells is the constitutive expression of ID proteins in the former and inducible expression in the latter. ID proteins function as antagonists of the E protein transcription factors that play critical roles in lymphoid specification as well as B and T-lymphocyte development. In this review, we examine the transcriptional mechanisms controlling the development of innate lymphocytes, including natural killer cells and the recently identified innate lymphoid cells (ILC1, ILC2, and ILC3), and innate-like lymphocytes, including natural killer T cells, with an emphasis on the known requirements for the ID proteins. PMID:25123285

  9. Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells

    PubMed Central

    Dai, Meifang; Zhuang, Yuan

    2014-01-01

    The innate-like T cells expressing Vγ1.1 and Vδ6.3 represent a unique T cell lineage sharing features with both the γδ T and the invariant NKT cells. The population size of Vγ1.1+Vδ6.3+ T cells is tightly controlled and usually contributes to a very small proportion of thymic output, but the underlying mechanism remains enigmatic. Deletion of Id3, an inhibitor of E-protein transcription factors, can induce an expansion of the Vγ1.1+Vδ6.3+ T cell population. This phenotype is much stronger on the C57Bl/6 background than on the 129/sv background. Using quantitative trait linkage analysis, we identified Id2, a homologue of Id3, to be the major modifier of Id3 in limiting Vγ1.1+Vδ6.3+ T cell expansion. The Vγ1.1+Vδ6.3+ phenotype is attributed to an intrinsic weakness of Id2 transcription from Id2 C57Bl/6 allele, leading to an overall reduced dosage of Id proteins. However, complete removal of both Id2 and Id3 genes in developing T cells suppressed the expansion of Vγ1.1+Vδ6.3+ T cells due to decreased proliferation and increased cell death. We showed that conditional knockout of Id2 alone is sufficient to promote a moderate expansion of γδ T cells. These regulatory effects of Id2 and Id3 on Vγ1.1+Vδ6.3+ T cells are mediated by titration of E protein activity, since removing one or more copies of E protein genes can restore Vγ1.1+Vδ6.3+ T cell expansion in Id2 and Id3 double conditional knockout mice. Our data indicated that Id2 and Id3 collaboratively control survival and expansion of the γδ lineage through modulating a proper threshold of E-proteins. PMID:24379125

  10. Study of multilayer-reflected beam profiles and their coherence properties using beamlines ID19 (ESRF) and 32-ID (APS)

    SciTech Connect

    Rack, A.; Assoufid, L.; Dietsch, R.; Weitkamp, T.; Trabelsi, S. Bauer; Rack, T.; Siewert, F.; Kraemer, M.; Holz, Th.; Zanette, I.; Le, W.-K.; Cloetens, P.; Ziegler, E.

    2012-05-17

    The use of multilayer mirrors is an interesting alternative for reflective X-ray monochromatization with respect to reflection from crystal optics. The increased photon flux density due to the multilayers' larger bandwidth is of crucial importance for, e.g, full-field X-ray imaging applications. Drawbacks are the introduced modifications of the reflected beam profile as well as a certain loss of coherence, summarized as wavefront degradation. Our recent work has shown that the modification of the beam profile can vary with, e.g., the material composition of the coating applied. In order to verify our findings, a beamline round-robin has been initiated, comparing the wavefront profiles after reflection by selected multilayers at beamlines 32-ID (Advanced Photon Source) and ID19 (European Synchrotron Radiation Facility) with our initial results acquired at BM05 (ESRF) [1].

  11. 19. Photocopy of photograph (original print at the Public Service ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Photocopy of photograph (original print at the Public Service Company of Colorado, Shoshone Hydro Plant Collection, Glenwood Springs, Colorado) Photographer unknown, Circa 1940 SHOSHONE HYDROELECTRIC PLANT - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

  12. 17. Photocopy of photograph (original print at the Public Service ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Photocopy of photograph (original print at the Public Service Company of Colorado, Shoshone Hydro Plant Collection, Glenwood Springs, Colorado) Photographer unknown, Circa 1935 SHOSHONE HYDROELECTRIC PLANT, VIEW TO THE NORTHEAST - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

  13. 18. Photocopy of photograph (original print at the Public Service ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Photocopy of photograph (original print at the Public Service Company of Colorado, Shoshone Hydro Plant Collection, Glenwood Springs, Colorado) Photographer unknown, Circa 1935 SHOSHONE HYDROELECTRIC PLANT, VIEW TO THE NORTHWEST - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

  14. Comparison of Perinatal Risk Factors Associated with Autism Spectrum Disorder (ASD), Intellectual Disability (ID), and Co-Occurring ASD and ID

    ERIC Educational Resources Information Center

    Schieve, Laura A.; Clayton, Heather B.; Durkin, Maureen S.; Wingate, Martha S.; Drews-Botsch, Carolyn

    2015-01-01

    While studies report associations between perinatal outcomes and both autism spectrum disorder (ASD) and intellectual disability (ID), there has been little study of ASD with versus without co-occurring ID. We compared perinatal risk factors among 7547 children in the 2006-2010 Autism and Developmental Disability Monitoring Network classified as

  15. Combined deletion of Id2 and Id3 genes reveals multiple roles for E-proteins in iNKT cell development and expansion

    PubMed Central

    Li, Jia; Wu, Di; Jiang, Ning; Zhuang, Yuan

    2013-01-01

    The invariant natural killer T (iNKT) cells represent a unique group of αβ T cells that have been classified based on their exclusive usage of the invariant Vα14Jα18 TCRα chain and their innate like effector function. Thus far, the transcriptional programs that control Vα14Jα18 TCRα rearrangements and the population size of iNKT cells are still incompletely defined. E-protein transcription factors have been shown to play necessary roles in the development of multiple T cell lineages including iNKT cell. Here, we examined E-protein functions in T cell development through combined deletion of genes encoding E-protein inhibitors, Id2 and Id3. Deletion of Id2 and Id3 in T cell progenitors resulted in a partial block at the preTCR selection checkpoint and a dramatic increase in numbers of iNKT cells. The increase in iNKT cells is accompanied with a biased rearrangement involving Vα14 to Jα18 recombination at the double positive stage and enhanced proliferation of iNKT cells. We further demonstrate that a 50% reduction of E-proteins can cause a dramatic switch from iNKT to innate like γδ T cell fate in Id2 and Id3 deficient mice. Collectively, these findings suggest that Id2 and Id3 mediated inhibition of E-proteins controls iNKT development by restricting lineage choice and population expansion. PMID:24123680

  16. Comparison of Perinatal Risk Factors Associated with Autism Spectrum Disorder (ASD), Intellectual Disability (ID), and Co-Occurring ASD and ID

    ERIC Educational Resources Information Center

    Schieve, Laura A.; Clayton, Heather B.; Durkin, Maureen S.; Wingate, Martha S.; Drews-Botsch, Carolyn

    2015-01-01

    While studies report associations between perinatal outcomes and both autism spectrum disorder (ASD) and intellectual disability (ID), there has been little study of ASD with versus without co-occurring ID. We compared perinatal risk factors among 7547 children in the 2006-2010 Autism and Developmental Disability Monitoring Network classified as…

  17. Improving IDS performance through group practice expense management.

    PubMed

    Witt, M J

    2001-09-01

    IDSs can turn around an owned group practice's poor financial performance by taking steps to more effectively manage the practice's expenses. The primary areas on which an IDS should focus its expense-management efforts are physician compensation, nonprovider staffing, and facility planning. The physician compensation system, for example, should include incentives for physicians to improve performance and increase productivity, and the size of the nonprovider staff should be adjusted according to patient volumes. Other areas in which changes in strategy may be required include information system investments; budgeting, accounts-payable, and purchasing processes; and corporate allocations of practice revenues to recover practice acquisition costs. PMID:11552583

  18. Quadruplex Integrated DNA (QuID) Nanosensors for Monitoring Dopamine.

    PubMed

    Morales, Jennifer M; Skipwith, Christopher G; Clark, Heather A

    2015-01-01

    Dopamine is widely innervated throughout the brain and critical for many cognitive and motor functions. Imbalances or loss in dopamine transmission underlie various psychiatric disorders and degenerative diseases. Research involving cellular studies and disease states would benefit from a tool for measuring dopamine transmission. Here we show a Quadruplex Integrated DNA (QuID) nanosensor platform for selective and dynamic detection of dopamine. This nanosensor exploits DNA technology and enzyme recognition systems to optically image dopamine levels. The DNA quadruplex architecture is designed to be compatible in physically constrained environments (110 nm) with high flexibility, homogeneity, and a lower detection limit of 110 µM. PMID:26287196

  19. Quadruplex Integrated DNA (QuID) Nanosensors for Monitoring Dopamine

    PubMed Central

    Morales, Jennifer M.; Skipwith, Christopher G.; Clark, Heather A.

    2015-01-01

    Dopamine is widely innervated throughout the brain and critical for many cognitive and motor functions. Imbalances or loss in dopamine transmission underlie various psychiatric disorders and degenerative diseases. Research involving cellular studies and disease states would benefit from a tool for measuring dopamine transmission. Here we show a Quadruplex Integrated DNA (QuID) nanosensor platform for selective and dynamic detection of dopamine. This nanosensor exploits DNA technology and enzyme recognition systems to optically image dopamine levels. The DNA quadruplex architecture is designed to be compatible in physically constrained environments (110 nm) with high flexibility, homogeneity, and a lower detection limit of 110 µM. PMID:26287196

  20. The Travis County, Texas, meteorites

    NASA Astrophysics Data System (ADS)

    McCoy, T. J.; Ehlmann, A. J.; Keil, K.

    1995-05-01

    Studies of 52 specimens recovered from the find site of the original Travis County meteorite reveal the presence of two distinct meteorites. Travis County (a), which includes the original Travis County meteorite, is the more abundant meteorite and is classified as an H5(S4) shock-blackened chondrite. Travis County (b) is classified as an H4(S2) chondrite with rare chondritic clasts of H group parentage, indicating that the meteorite is a breccia.

  1. Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis

    NASA Astrophysics Data System (ADS)

    Fong, Sylvia; Itahana, Yoko; Sumida, Tomoki; Singh, Jarnail; Coppe, Jean-Philippe; Liu, Yong; Richards, Peter C.; Bennington, James L.; Lee, Nancy M.; Debs, Robert J.; Desprez, Pierre-Yves

    2003-11-01

    Mammary epithelial cells constitutively expressing Id-1 protein are unable to differentiate, acquire the ability to proliferate, and invade the extracellular matrix. In addition, Id-1 is aberrantly over-expressed in aggressive and metastatic breast cancer cells, as well as in human breast tumor biopsies from infiltrating carcinomas, suggesting Id-1 might be an important regulator of breast cancer progression. We show that human metastatic breast cancer cells become significantly less invasive in vitro and less metastatic in vivo when Id-1 is down-regulated by stable transduction with antisense Id-1. Expression of the matrix metalloproteinase MT1-MMP is decreased in proportion to the decrease in Id-1 protein levels, representing a potential mechanism for the reduction of invasiveness. Further, to more accurately recapitulate the biology of and potential therapeutic approaches to tumor metastasis, we targeted Id-1 expression systemically in tumor-bearing mice by using a nonviral approach. We demonstrate significant reduction of both Id-1 and MT1-MMP expressions as well as the metastatic spread of 4T1 breast cancer cells in syngeneic BALB/c mice. In conclusion, our studies have identified Id-1 as a critical regulator of breast cancer progression and suggest the feasibility of developing novel therapeutic approaches to target Id-1 expression to reduce breast cancer metastasis in humans.

  2. Practical use of lens structures in ID documents

    NASA Astrophysics Data System (ADS)

    van den Berg, Jan

    2006-02-01

    Polymer ID-documents mostly are made of plastic foils which are laminated to one massive card by applying heat and pressure. During this lamination process, some structures can be transferred from the metal laminating plate to the card surface. These structures can be shaped in the form of a lens. Both are possible, positive as well as negative lens structures, for example in the form of lines or (micro) text. Also lens arrays of cylinder lenses can be made. The lens structures can be combined with the security design which is printed on the document, resulting in optically variable effects of moire patterns. Also these lens structures can be combined with laser engraving during the personalization of the document. In this way it is even possible to personalize the document with a stereo photo, the so called stereogram. The tactility of the structures on the ID-document, combined with the optical effects, makes these structures a very strong first line security feature. This kind of security features are completely integrated into the card body and combined with the personalization, which make them hard to manipulate by counterfeiters. Because of the fact that the human eye can handle images with a lot of noise, the optical quality of the lenses as well as the focal point seems to be less important for the most applications. Some applications need a rather high optical quality.

  3. Calibrating GMOS Spectra to the Lick/IDS Index System

    NASA Astrophysics Data System (ADS)

    Miller, Bryan W.; Trancho, G.; Puzia, T.

    2009-12-01

    We present preliminary results on the calibration of Gemini GMOS spectra to the Lick line index system. The Lick system of spectral line indices is one of the most commonly used methods of determining ages and metallicities of unresolved (integrated light) spectral populations. However, care must be taken to calibrate the measured indices to the standard system before making comparisons with models. The calibration of the Lick/IDS system is complicated because the original Lick spectra were not flux calibrated, so there are usually systematic effects due to differences in continuum shape. In addition, the spectra must be broadened to the Lick spectral resolution. Proper calibration involves observing many of the original Lick/IDS standard stars and deriving offsets to the standard system. The indices of the standard stars must bracket the expected indices of the science targets, so many stars may be needed if a wide range of metallicities or ages is expected. We have observed several dozen Lick standard stars with GMOS North and South on the Gemini telescopes and we present details on the data reduction and the initial calibration to the Lick system. Based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the NSF on behalf of the Gemini partnership: the National Science Foundation (United States), the Particle Physics and Astronomy Research Council (United Kingdom), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), CNPq (Brazil), and CONICET (Argentina).

  4. Humboldt County Employer Survey.

    ERIC Educational Resources Information Center

    Lyons, Dave

    A project was undertaken in Humboldt County to collect information from large and small businesses in the areas of agriculture, mining, manufacturing, transportation, wholesale and retail, finance, services, and public information with respect to their employee requirements and needs. In all, 451 firms were surveyed to determine the size of the

  5. Westchester County Employers Survey.

    ERIC Educational Resources Information Center

    Lee, Marcia M.

    The Westchester County Employers Survey was done in May 2003 in order learn more about employee training needs, how they accomplished these needs, and how it would be possible for the Westchester Community College to fulfill these needs. Out of the 639 surveys sent, 145 were returned in a satisfactory format, which produces a 22.6% return rate.

  6. Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors.

    PubMed

    Sikder, Hashmat; Huso, David L; Zhang, Hong; Wang, Binghe; Ryu, Byungwoo; Hwang, Sam T; Powell, Jonathan D; Alani, Rhoda M

    2003-10-01

    Id genes regulate tumor angiogenesis and loss of Id1 inhibits tumor xenograft growth in mice. Here we evaluate the role of Id1 in a more clinically relevant tumor model system using a two-step chemical carcinogenesis protocol. Remarkably, we find that Id1-/- mice are more susceptible to skin tumorigenesis compared to their wild-type counterparts. Cutaneous neoplasms in Id1-/- mice show increased proliferation without alterations in tumor angiogenesis; however, Id1-/- mice possess 50% fewer cutaneous gammadelta T cells than their wild-type counterparts due to an intrinsic migration defect associated with loss of expression of the chemokine receptor, CXCR4. We suggest that there are important differences between the mechanisms of angiogenesis in transplanted and autochthonous tumors and that these findings will have significant implications for the potential utility of antiangiogenic therapies in cancer. PMID:14585356

  7. The Implementation of C-ID, R2D2 Model on Learning Reading Comprehension

    ERIC Educational Resources Information Center

    Rayanto, Yudi Hari; Rusmawan, Putu Ngurah

    2016-01-01

    The purposes of this research are to find out, (1) whether C-ID, R2D2 model is effective to be implemented on learning Reading comprehension, (2) college students' activity during the implementation of C-ID, R2D2 model on learning Reading comprehension, and 3) college students' learning achievement during the implementation of C-ID, R2D2 model on…

  8. Idaho National Laboratory Supervisory Control and Data Acquisition Intrusion Detection System (SCADA IDS)

    SciTech Connect

    Jared Verba; Michael Milvich

    2008-05-01

    Current Intrusion Detection System (IDS) technology is not suited to be widely deployed inside a Supervisory, Control and Data Acquisition (SCADA) environment. Anomaly- and signature-based IDS technologies have developed methods to cover information technology-based networks activity and protocols effectively. However, these IDS technologies do not include the fine protocol granularity required to ensure network security inside an environment with weak protocols lacking authentication and encryption. By implementing a more specific and more intelligent packet inspection mechanism, tailored traffic flow analysis, and unique packet tampering detection, IDS technology developed specifically for SCADA environments can be deployed with confidence in detecting malicious activity.

  9. Fake ID ownership and heavy drinking in underage college students: prospective findings.

    PubMed

    Martinez, Julia A; Rutledge, Patricia C; Sher, Kenneth J

    2007-06-01

    The authors examined the ownership of false identification (fake ID) for the purpose of obtaining alcohol and the relation of fake ID ownership to heavy drinking in a longitudinal sample of college students under 21 years of age. A sample of 3,720 undergraduates was assessed the summer prior to college entrance and during the 4 semesters comprising freshman and sophomore years. Regression analyses were used to estimate bidirectional relations between consumption and fake ID ownership. Sex, Greek membership, and prior drinking were controlled. Results showed that fake ID ownership increased over time (12.5% pre-college to 32.2% fourth semester) and that Greek members were more likely than others to own fake IDs. Fake ID ownership predicted concurrent and next-semester heavy drinking with increasing strength over time. Also, the acquisition (onset) of fake ID ownership at each time point was predicted by previous-semester consumption. When traditional, robust risk factors of consumption are controlled, fake ID ownership meaningfully relates to heavy drinking in college. It thus presents a significant public health problem, addressable through training for alcohol servers and retailers, punitive measures toward fake ID owners, and other possible interventions. PMID:17563142

  10. Rodent BC1 RNA gene as a master gene for ID element amplification.

    PubMed Central

    Kim, J; Martignetti, J A; Shen, M R; Brosius, J; Deininger, P

    1994-01-01

    ID elements are short interspersed repetitive DNA elements (SINEs) which have amplified in rodent genomes via retroposition, a process involving an RNA intermediate. BC1, an abundant ID-related transcript, is transcribed from a conserved, single-copy gene in rodents. The gene encoding BC1 RNA represents one of the earliest and possibly the first ID-containing sequence. Comparison of consensus sequences of each rodent ID with its corresponding BC1 RNA gene showed that the variations of BC1 RNA within rodents corresponded to specific changes within the ID consensus sequence for each rodent species. This supports the hypothesis that the BC1 gene is a master gene responsible for the amplification and evolution of ID elements. The rat ID family consists of at least four subfamilies, with the oldest subfamily having been derived from the BC1 RNA. The other three subfamilies appear to have been derived from a new master gene(s), which has been responsible for the large increase in ID element copy number within the rat genome. We have found that the guinea pig genome contains two copies of the BC1 gene, apparently the result of a DNA-mediated duplication event. Both of these guinea pig BC1 genes have a conserved TATA-like element in the 5' flanking region and have contributed to guinea pig ID amplifications. Images PMID:8170955

  11. Id expression in amphioxus and lamprey highlights the role of gene cooption during neural crest evolution

    NASA Technical Reports Server (NTRS)

    Meulemans, Daniel; McCauley, David; Bronner-Fraser, Marianne

    2003-01-01

    Neural crest cells are unique to vertebrates and generate many of the adult structures that differentiate them from their closest invertebrate relatives, the cephalochordates. Id genes are robust markers of neural crest cells at all stages of development. We compared Id gene expression in amphioxus and lamprey to ask if cephalochordates deploy Id genes at the neural plate border and dorsal neural tube in a manner similar to vertebrates. Furthermore, we examined whether Id expression in these cells is a basal vertebrate trait or a derived feature of gnathostomes. We found that while expression of Id genes in the mesoderm and endoderm is conserved between amphioxus and vertebrates, expression in the lateral neural plate border and dorsal neural tube is a vertebrate novelty. Furthermore, expression of lamprey Id implies that recruitment of Id genes to these cells occurred very early in the vertebrate lineage. Based on expression in amphioxus we postulate that Id cooption conferred sensory cell progenitor-like properties upon the lateral neurectoderm, and pharyngeal mesoderm-like properties upon cranial neural crest. Amphioxus Id expression is also consistent with homology between the anterior neurectoderm of amphioxus and the presumptive placodal ectoderm of vertebrates. These observations support the idea that neural crest evolution was driven in large part by cooption of multipurpose transcriptional regulators from other tissues and cell types.

  12. Image processing by Intensity-Dependent Spread (IDS)

    NASA Technical Reports Server (NTRS)

    Cornsweet, Tom N.

    1989-01-01

    As retinal illuminance is lowered, the human visual system integrates the effects of photon absorptions over larger areas and longer times. A theory of the process that might underlie these changes is called Intensity-Dependent Spread (IDS). Each input point gives rise to a pattern of excitation that spreads to a region of the total excitation it sees. The unique aspect of the theory is the assumption that, although the amplitude of the excitation pattern at its center increases with input illuminance, its width decreases in such a way that its volume remains constant. Application of this theory to image processing reveals that it displays a number of unexpected and potentially useful properties. Among them are edge enhancement and independence from scene illumination.

  13. New possibilities at beamline ID27 of the ESRF

    NASA Astrophysics Data System (ADS)

    Mezouar, Mohamed; Garbarino, Gaston; Parisiadis, Paraskevas; Jacobs, Jeroen; Bauchau, Stany

    2013-06-01

    Beamline ID27 is fully optimised for monochromatic high resolution XRD in order to address the most exciting and challenging questions related to science at very high pressures. This beamline can easily accommodate very complex sample environments such as the double-sided laser heating system, the Paris-Edinburgh press and the HP helium cryostat. These techniques are powerful tools to explore a very wide pressure (P > 2 Mbar) and temperature domain (5 < T < 5000 K). The beamline components (source, optics and detectors) are entirely designed to give the best possible response to these very demanding conditions. The most recent developments including an in situ CO2 laser heating system and a high temperature resistively heated diamond anvil cell will be presented.

  14. DeID - a data sharing tool for neuroimaging studies.

    PubMed

    Song, Xuebo; Wang, James; Wang, Anlin; Meng, Qingping; Prescott, Christian; Tsu, Loretta; Eckert, Mark A

    2015-01-01

    Funding institutions and researchers increasingly expect that data will be shared to increase scientific integrity and provide other scientists with the opportunity to use the data with novel methods that may advance understanding in a particular field of study. In practice, sharing human subject data can be complicated because data must be de-identified prior to sharing. Moreover, integrating varied data types collected in a study can be challenging and time consuming. For example, sharing data from structural imaging studies of a complex disorder requires the integration of imaging, demographic and/or behavioral data in a way that no subject identifiers are included in the de-identified dataset and with new subject labels or identification values that cannot be tracked back to the original ones. We have developed a Java program that users can use to remove identifying information in neuroimaging datasets, while still maintaining the association among different data types from the same subject for further studies. This software provides a series of user interaction wizards to allow users to select data variables to be de-identified, implements functions for auditing and validation of de-identified data, and enables the user to share the de-identified data in a single compressed package through various communication protocols, such as FTPS and SFTP. DeID runs with Windows, Linux, and Mac operating systems and its open architecture allows it to be easily adapted to support a broader array of data types, with the goal of facilitating data sharing. DeID can be obtained at http://www.nitrc.org/projects/deid. PMID:26441500

  15. Underground Storage Tank Integrated Demonstration (UST-ID). Technology summary

    SciTech Connect

    Not Available

    1994-02-01

    The DOE complex currently has 332 underground storage tanks (USTs) that have been used to process and store radioactive and chemical mixed waste generated from weapon materials production. Very little of the over 100 million gallons of high-level and low-level radioactive liquid waste has been treated and disposed of in final form. Two waste storage tank design types are prevalent across the DOE complex: single-shell wall and double-shell wall designs. They are made of stainless steel, concrete, and concrete with carbon steel liners, and their capacities vary from 5000 gallons (19 m{sup 3}) to 10{sup 6} gallons (3785 m{sup 3}). The tanks have an overburden layer of soil ranging from a few feet to tens of feet. Responding to the need for remediation of tank waste, driven by Federal Facility Compliance Agreements (FFCAs) at all participating sites, the Underground Storage Tank Integrated Demonstration (UST-ID) Program was created by the US DOE Office of Technology Development in February 1991. Its mission is to focus the development, testing, and evaluation of remediation technologies within a system architecture to characterize, retrieve, treat to concentrate, and dispose of radioactive waste stored in USTs at DOE facilities. The ultimate goal is to provide safe and cost-effective solutions that are acceptable to the public and the regulators. The UST-ID has focused on five DOE locations: the Hanford Site, which is the host site, in Richland, Washington; the Fernald Site in Fernald, Ohio; the Idaho National Engineering Laboratory near Idaho Falls, Idaho; the Oak Ridge Reservation in Oak Ridge, Tennessee, and the Savannah River Site in Savannah River, South Carolina.

  16. DeID a data sharing tool for neuroimaging studies

    PubMed Central

    Song, Xuebo; Wang, James; Wang, Anlin; Meng, Qingping; Prescott, Christian; Tsu, Loretta; Eckert, Mark A.

    2015-01-01

    Funding institutions and researchers increasingly expect that data will be shared to increase scientific integrity and provide other scientists with the opportunity to use the data with novel methods that may advance understanding in a particular field of study. In practice, sharing human subject data can be complicated because data must be de-identified prior to sharing. Moreover, integrating varied data types collected in a study can be challenging and time consuming. For example, sharing data from structural imaging studies of a complex disorder requires the integration of imaging, demographic and/or behavioral data in a way that no subject identifiers are included in the de-identified dataset and with new subject labels or identification values that cannot be tracked back to the original ones. We have developed a Java program that users can use to remove identifying information in neuroimaging datasets, while still maintaining the association among different data types from the same subject for further studies. This software provides a series of user interaction wizards to allow users to select data variables to be de-identified, implements functions for auditing and validation of de-identified data, and enables the user to share the de-identified data in a single compressed package through various communication protocols, such as FTPS and SFTP. DeID runs with Windows, Linux, and Mac operating systems and its open architecture allows it to be easily adapted to support a broader array of data types, with the goal of facilitating data sharing. DeID can be obtained at http://www.nitrc.org/projects/deid. PMID:26441500

  17. Mono County update

    SciTech Connect

    Lyster, D. )

    1988-12-01

    The Mono County Board of Supervisors approved the issuance of a use-permit for the Mammoth-Pacific II geothermal power plant. The power plant will be a binary, air-cooled, 10-megawatt, net, project. An appeal was filed by the California Department of Fish and Game, and the permit will not take effect until this appeal is resolved. Mono County also issued a project use-permit to proposers of Bonneville Pacific Corporations Mammoth Chance Geothermal Project, also a 10-megawatt, net, binary and air-cooled project. The permit was appealed by the Sierra Club, Cal-Trout, and the California Department of Fish and Game. Now, a subsequent EIR must be prepared for public review and comment. The subsequent EIR will address the issue of cumulative impacts and will include a discussion of new information.

  18. Mono County update

    SciTech Connect

    Lyster, D.L.

    1987-07-01

    In May 1987, the Mono County Energy Management Department recommended that a two-year moratorium be placed on geothermal power production projects on private lands within the Mono-Long Valley KGRA. The intent of the proposed moratorium was to allow for the collection and evaluation of hydrologic monitoring data in the Long Valley Caldera. Now, to still achieve this end, the Energy Management Department will suggest that mitigation measures and project-specific monitoring requirements be implemented via the California Environmental Quality Act (CEQA) documentation and the county use permit process. The monitoring data will provide important information to Mono County decision-makers regarding potential adverse impacts from geothermal production on such local resources as Hot Creek Gorge, the Hot Creek Fish Hatchery, and Hot Creek, itself. The Mammoth/Chance Geothermal Project is the proposed construction and operation of a 10 megawatt, net, geothermal binary-cycle power plant and production- and injection-well field by Bonneville Pacific Corporation. The project is currently under environmental review, pursuant to CEQA requirements. The Mono County Energy Management Director is providing assistance to the Town of Mammoth Lakes on its California Energy Commission (CEC) grant-funded resource assessment project. The grant of $220,000 provides for the drilling of at least two temperature-gradient wells (exploratory wells) within the town limits. If a geothermal resource is detected and found to provide adequate flows at a suitable temperature, the Town of Mammoth Lakes will proceed in the development of a geothermal space-heating system to provide heat to such users as the Centinela Mammoth Hospital, Mammoth elementary and high schools, the Gateway Industrial Park, and future residential development projects.

  19. Mono County update

    SciTech Connect

    Lyster, D.L.

    1987-06-01

    On February 9, 1988, the Mono County Board of Supervisors voted to approve Bonneville Pacific Corporation's Mammoth Chance Geothermal Project. The project is an air-cooled, binary, geothermal power plant, 10 megawatts, net. The Mono County Board of Supervisors issued a project use-permit with vigorous and stringent conditions. Specific emphasis was placed on the establishment of a monitoring program designed to detect the effects of geothermal development on the springs at the Hot Creek Fish Hatchery and Hot Creek Gorge. On October 5, 1987, the Mono County Planning Commission granted a use-permit to Mammoth Pacific for its Mammoth Pacific II Project, a binary, air-cooled, geothermal power plant, 10 megawatts, net. The issuance of the use-permit instigated an appeal by the Sierra Club. That appeal was heard on February 22, 1988, At the end of the testimony, the Board of Supervisors voted to uphold the appeal of the Sierra Club, thereby denying the project by a vote of 3 to 2. The main areas of concern voiced by the majority of the Board included potential hydrologic impacts to Hot Creek Gorge and Hot Creek Fish Hatchery, visual impacts, and impacts to mule deer migration and survival. One of the options now available to Mammoth Pacific is to request that the project be denied without prejudice. This would allow Mammoth Pacific to return to the Board immediately with additional material regarding its concerns.

  20. Snohomish County Biodiesel Project

    SciTech Connect

    Terrill Chang; Deanna Carveth

    2010-02-01

    Snohomish County in western Washington State began converting its vehicle fleet to use a blend of biodiesel and petroleum diesel in 2005. As prices for biodiesel rose due to increased demand for this cleaner-burning fuel, Snohomish County looked to its farmers to “grow” this fuel locally. Suitable seed crops that can be crushed to extract oil for use as biodiesel feedstock include canola, mustard, and camelina. The residue, or mash, has high value as an animal feed. County farmers began with 52 acres of canola and mustard crops in 2006, increasing to 250 acres and 356 tons in 2008. In 2009, this number decreased to about 150 acres and 300 tons due to increased price for mustard seed.

  1. High-speed readout method of ID information on a large amount of electronic tags

    NASA Astrophysics Data System (ADS)

    Nagate, Wataru; Sasabe, Masahiro; Nakano, Hirotaka

    2006-10-01

    An electronic tag such as RFID is expected to create new services that cannot be achieved by the traditional bar code. Specifically, in a distribution system, simultaneous readout method of a large amount of electronic tags embedded in products is required to reduce costs and time. In this paper, we propose novel methods, called Response Probability Control (RPC), to accomplish this requirement. In RPC, a reader firstly sends an ID request to electronic tags in its access area. It succeeds reading information on a tag only if other tags do not respond. To improve the readout efficiency, the reader appropriately controls the response probability in accordance with the number of tags. However, this approach cannot entirely avoid a collision of multiple responses. When a collision occurs, ID information is lost. To reduce the amount of lost data, we divide the ID registration process into two steps. The reader first gathers the former part of the original ID, called temporal ID, according to the above method. After obtaining the temporal ID, it sequentially collects the latter part of ID, called remaining ID, based on the temporal ID. Note that we determine the number of bits of a temporal ID in accordance with the number of tags in the access area so that each tag can be distinguishable. Through simulation experiments, we evaluate RPC in terms of the readout efficiency. Simulation results show that RPC can accomplish the readout efficiency 1.17 times higher than the traditional method where there are a thousand of electronic tags whose IDs are 128 bits.

  2. 77 FR 59639 - Bear Lake National Wildlife Refuge, Bear Lake County, ID and Oxford Slough Waterfowl Production...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... notice in the Federal Register (75 FR 35829; June 23, 2010). Bear Lake National Wildlife Refuge Bear Lake... birds nest at Bear Lake NWR, including large concentrations of colonial waterbirds, and many other... additional facilities are developed, and a more diverse array of wetland habitats allows a wider variety...

  3. 76 FR 66034 - Proposed Foreign-Trade Zone-Ada and Canyon Counties, ID, Under Alternative Site Framework...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... (CBP) port of entry, under the alternative site framework (ASF) adopted by the Board (74 FR 1170-1173, 1/12/09 (correction 74 FR 3987, 1/22/09); 75 FR 71069-71070, 11/22/10). The ASF is an option for... of entry. FTZ 192 in Meridian, Idaho was established on February 17, 1993 (Board Order 629, 58...

  4. 77 FR 52680 - Foreign-Trade Zone 242-Boundary County, ID, Notification of Proposed Production Activity, AREVA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ... finished cascades (duty rate 2.6%) for the foreign status inputs noted below. Components and materials... pipework/fittings, parts of cascades, vacuum pumps, UF6 pumps, heat exchange units, autoclaves,...

  5. 78 FR 33433 - Bear Lake National Wildlife Refuge, Bear Lake County, ID, and Oxford Slough Waterfowl Production...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-04

    ... Federal Register (75 FR 35829; June 23, 2010). We released the draft CCP/EA to the public, announcing and requesting comments in a notice of availability in the Federal Register (77 FR 59639; September 28, 2012... public comments on the draft CCP/EA for 30 days, from September 28 to October 29, 2012 (77 FR 59639)....

  6. 77 FR 55486 - Agency Information Collection Activities: Importer ID Input Record

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-10

    ... Federal Register (76 FR 37696) on June 22, 2012, allowing for a 60-day comment period. This notice allows... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Importer ID Input... accordance with the Paperwork Reduction Act: Importer ID Input Record (CBP Form 5106). This is a...

  7. 77 FR 33794 - True Product ID, Inc.; Order of Suspension of Trading

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ... COMMISSION True Product ID, Inc.; Order of Suspension of Trading June 5, 2012. It appears to the Securities... securities of True Product ID, Inc. (``True Product'') because it has not filed a periodic report since it... from 9:30 a.m. EDT on June 5, 2012, through 11:59 p.m. EDT on June 18, 2012. By the Commission. Jill...

  8. Wicked ID: Conceptual Framework for Considering Instructional Design as a Wicked Problem

    ERIC Educational Resources Information Center

    Becker, Katrin

    2007-01-01

    The process of instructional design has parallels in other design disciplines. Software design is one that has experienced intense attention in the last 30 or so years, and many lessons learned there can be applied to ID. Using software design as a springboard, this concept paper seeks to propose a new approach to ID. It suggests that…

  9. The Numbers Game: Phasing in Generated ID Numbers at the University of Oregon

    ERIC Educational Resources Information Center

    Eveland, Sue

    2005-01-01

    With all the recent headlines about security breaches and information loss at financial and educational institutions, the higher education community needs to address the issue of using social security numbers as ID numbers. The University of Oregon undertook a change process to assign generated ID numbers to all records in their information

  10. 6 CFR 37.23 - Reissued REAL ID driver's licenses and identification cards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... time a REAL ID driver's license or identification card is reissued, to ensure that the individual receiving the reissued REAL ID driver's license or identification card is the same individual to whom the driver's license or identification card was originally issued. (b) Remote/Non-in-person...

  11. 6 CFR 37.23 - Reissued REAL ID driver's licenses and identification cards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... time a REAL ID driver's license or identification card is reissued, to ensure that the individual receiving the reissued REAL ID driver's license or identification card is the same individual to whom the driver's license or identification card was originally issued. (b) Remote/Non-in-person...

  12. 6 CFR 37.23 - Reissued REAL ID driver's licenses and identification cards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... time a REAL ID driver's license or identification card is reissued, to ensure that the individual receiving the reissued REAL ID driver's license or identification card is the same individual to whom the driver's license or identification card was originally issued. (b) Remote/Non-in-person...

  13. 6 CFR 37.23 - Reissued REAL ID driver's licenses and identification cards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... time a REAL ID driver's license or identification card is reissued, to ensure that the individual receiving the reissued REAL ID driver's license or identification card is the same individual to whom the driver's license or identification card was originally issued. (b) Remote/Non-in-person...

  14. 6 CFR 37.23 - Reissued REAL ID driver's licenses and identification cards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... identification cards. 37.23 Section 37.23 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REAL ID DRIVER'S LICENSES AND IDENTIFICATION CARDS Minimum Documentation, Verification, and Card Issuance Requirements § 37.23 Reissued REAL ID driver's licenses and identification cards. (a)...

  15. 6 CFR 37.25 - Renewal of REAL ID driver's licenses and identification cards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... identification cards. 37.25 Section 37.25 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REAL ID DRIVER'S LICENSES AND IDENTIFICATION CARDS Minimum Documentation, Verification, and Card Issuance Requirements § 37.25 Renewal of REAL ID driver's licenses and identification cards. (a)...

  16. E and Id proteins influence invariant Natural Killer T cell sublineage differentiation and proliferation

    PubMed Central

    D'Cruz, Louise M.; Stradner, Martin H.; Yang, Cliff Y.; Goldrath, Ananda W.

    2014-01-01

    Disease outcome is known to be influenced by defined subsets of invariant Natural Killer T (iNKT) cells residing in distinct locations within peripheral tissue. However, the factors governing the development of these unique iNKT sublineages during thymic development are unknown. Here we explored the mechanism by which E protein transcription factors and their negative regulators, the Id proteins control the development of iNKT sublineages after positive selection. We found that E proteins directly bound the PLZF promoter and were required for expression of this lineage-defining transcription factor and for the maturation and expansion of thymic iNKT cells. Moreover, expression of the negative regulators of E proteins, Id2 and Id3, defined distinct iNKT cell sublineages. Id3 was expressed in PLZFhigh NKT2 cells and loss of Id3 allowed for increased thymic iNKT cell expansion and abundance of the PLZF+ NKT2 sublineage. Id2 was expressed in TBET+ NKT1 cells and both Id proteins were required for the formation of this sublineage. Thus, we provide insight into E and Id protein regulation of iNKT cell proliferation and differentiation to specific sublineages during development in the thymus. PMID:24470501

  17. Documenting the Undocumented: A Review of the United States' First Municipal ID Program

    ERIC Educational Resources Information Center

    Lagunes, Paul F.; Levin, Brian M.; Ditlmann, Ruth K.

    2012-01-01

    The City of New Haven, CT, sought to promote the assimilation of its immigrants by becoming the first American city to provide a government-backed ID, the Elm City Resident Card, to all residents. This article tests the policy's effectiveness in commerce. We find that Hispanics/Latinos are asked to present an ID more than Whites/Anglos, showing…

  18. Development and Evaluation of LEGUME ID: A ToolBook Multimedia Module.

    ERIC Educational Resources Information Center

    Hannaway, David B.; And Others

    1992-01-01

    Describes the development and advantages of LEGUME ID, a multimedia module for agricultural education. LEGUME ID is an example of how teachers, given the opportunity through accessible computer software programs, can create powerful teaching tools. Summarized is a student response to the use of this teacher-produced software program. (MCO)

  19. Rethinking Social Network Assessment for Students with Intellectual Disabilities (ID) in Postsecondary Education

    ERIC Educational Resources Information Center

    Eisenman, Laura T.; Farley-Ripple, Elizabeth; Culnane, Mary; Freedman, Brian

    2013-01-01

    Social networks of persons with intellectual disabilities (ID) have been characterized as smaller and less diverse than those of typical peers. Advocates have focused on strengthening those social networks by expanding circles of social support, protection, and friendship. As young adults with ID experience increasing levels of community…

  20. 78 FR 8596 - Hartford Financial Services Group, Inc., Commercial/Actuarial/ Information Delivery Services (IDS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    .../ Information Delivery Services (IDS)/Corporate & Financial Reporting Group, Hartford, CT; Notice of Negative... was published in the Federal Register on January 4, 2013 (78 FR 773). The Hartford-IDS Group is... financial reporting. Pursuant to 29 CFR 90.18(c), reconsideration may be granted under the...

  1. Security and Privacy Improvements for the Belgian eID Technology

    NASA Astrophysics Data System (ADS)

    Verhaeghe, Pieter; Lapon, Jorn; de Decker, Bart; Naessens, Vincent; Verslype, Kristof

    The Belgian Electronic Identity Card enables Belgian citizens to prove their identity digitally and to sign electronic documents. At the end of 2009, every Belgian citizen older than 12 years will have such an eID card. In the future, usage of the eID card may be mandatory. However, irresponsible use of the card may cause harm to individuals.

  2. 76 FR 16367 - Implementation of the Truth in Caller ID Act of 2009

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ...In this Notice of Proposed Rulemaking (NPRM), the Commission proposes rules to implement the Truth in Caller ID Act of 2009. The proposed rules prohibit caller ID spoofing done with the intent to defraud, cause harm, or wrongfully obtain anything of value. The Commission also seeks comments that will assist the Commission in preparing a statutorily required report to Congress on whether......

  3. 78 FR 40382 - Modification of Class D and E Airspace; Twin Falls, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... Federal Aviation Administration 14 CFR Part 71 Modification of Class D and E Airspace; Twin Falls, ID.... Reference to Class D airspace, omitted from the Title in the notice of proposed rulemaking is included in... Falls Joslin Field-Magic Valley Regional Airport, Twin Falls, ID (78 FR 25406). Interested parties...

  4. 77 FR 68065 - Amendment of Class D and Class E Airspace; Lewiston, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-15

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D and Class E Airspace; Lewiston, ID... Class D and Class E airspace areas at Lewiston, ID, to accommodate aircraft using Area Navigation (RNAV... (77 FR 32921). Interested parties were invited to participate in this rulemaking effort by...

  5. Integrated Design System (IDS) Tools for the Spacecraft Aeroassist/Entry Vehicle Design Process

    NASA Technical Reports Server (NTRS)

    Olynick, David; Braun, Robert; Langhoff, Steven R. (Technical Monitor)

    1997-01-01

    The definition of the Integrated Design System technology focus area as presented in the NASA Information Technology center of excellence strategic plan is described. The need for IDS tools in the aeroassist/entry vehicle design process is illustrated. Initial and future plans for spacecraft IDS tool development are discussed.

  6. Documenting the Undocumented: A Review of the United States' First Municipal ID Program

    ERIC Educational Resources Information Center

    Lagunes, Paul F.; Levin, Brian M.; Ditlmann, Ruth K.

    2012-01-01

    The City of New Haven, CT, sought to promote the assimilation of its immigrants by becoming the first American city to provide a government-backed ID, the Elm City Resident Card, to all residents. This article tests the policy's effectiveness in commerce. We find that Hispanics/Latinos are asked to present an ID more than Whites/Anglos, showing

  7. Matching the Judgmental Task with Standard Setting Panelist Expertise: The Item-Descriptor (ID) Matching Method

    ERIC Educational Resources Information Center

    Ferrara, Steve; Perie, Marianne; Johnson, Eugene

    2008-01-01

    Psychometricians continue to introduce new approaches to setting cut scores for educational assessments in an attempt to improve on current methods. In this paper we describe the Item-Descriptor (ID) Matching method, a method based on IRT item mapping. In ID Matching, test content area experts match items (i.e., their judgments about the knowledge…

  8. Overexpression of Id1 in transgenic mice promotes mammary basal stem cell activity and breast tumorigenesis

    PubMed Central

    Won, Hee-Young; Jang, Ki-Seok; Min, Kyueng-Whan; Jang, Si-Hyong; Woo, Jong-Kyu; Oh, Seung Hyun; Kong, Gu

    2015-01-01

    Inhibitor of differentiation/DNA binding (Id)1 is a crucial regulator of mammary development and breast cancer progression. However, its effect on stemness and tumorigenesis in mammary epithelial cells remains undefined. Herein, we demonstrate that Id1 induces mammary tumorigenesis by increasing normal and malignant mammary stem cell (MaSC) activities in transgenic mice. MaSC-enriched basal cell expansion and increased self-renewal and in vivo regenerative capacity of MaSCs are observed in the mammary glands of MMTV-Id1 transgenic mice. Furthermore, MMTV-Id1 mice develop ductal hyperplasia and mammary tumors with highly expressed basal markers. Id1 also increases breast cancer stem cell (CSC) population and activity in human breast cancer lines. Moreover, the effects of Id1 on normal and malignant stem cell activities are mediated by the Wnt/c-Myc pathway. Collectively, these findings provide in vivo genetic evidence of Id1 functions as an oncogene in breast cancer and indicate that Id1 regulates mammary basal stem cells by activating the Wnt/c-Myc pathway, thereby contributing to breast tumor development. PMID:25938540

  9. Microvascular lesions by estrogen-induced ID3: its implications in cerebral & cardiorenal vascular disease

    PubMed Central

    Das, Jayanta K.; Felty, Quentin

    2014-01-01

    Severe symptoms of cerebral and cardiorenal vascular diseases can be triggered when cerebral, coronary, or glomerular arterioles grow inappropriately as a result of abnormal cell proliferation. The risk factor(s) and molecular mechanisms responsible for microvascular lesion formation are largely unknown. Although controversial, both animal and epidemiological studies have shown that estrogen increases the risk of stroke which may be due to microvascular lesions. Since microvascular diseases are characterized by excessive vessel growth, it is plausible that estrogen-induced neovascularization contributes to the growth of microvascular lesions. We present evidence for how ID3 overexpression in endothelial cells contributes to the development of an estrogen-induced neovascular phenotype with an additional focus on Pyk2 kinase. Our data showed that ID3 overexpression increased neovascularization, cell migration, and spheroid growth of human cerebral microvascular endothelial cells, hCMEC/D3. ID3 overexpressing cells showed significant estrogen-induced G2/M phase transition. Estrogen treatment increased both ID3 phosphorylation and total protein that was inhibited by tamoxifen; and Pyk2 mediated estrogen-induced ID3 mRNA expression. These findings suggest that Pyk2 signals ID3 expression and ID3 is necessary for estrogen-induced neovascularization in hCMEC/D3 cells. A better understanding of how microvascular lesions depend on ID3 may open new avenues for prevention and treatment of neurological diseases. PMID:25129100

  10. Regulation of Id2 expression by CCAAT/enhancer binding protein β

    PubMed Central

    Karaya, Kazuhiro; Mori, Seiichi; Kimoto, Hisashi; Shima, Yoko; Tsuji, Yoshihito; Kurooka, Hisanori; Akira, Shizuo; Yokota, Yoshifumi

    2005-01-01

    Mice deficient for Id2, a negative regulator of basic helix–loop–helix (bHLH) transcription factors, exhibit a defect in lactation due to impaired lobuloalveolar development during pregnancy, similar to the mice lacking the CCAAT enhancer binding protein (C/EBP) β. Here, we show that Id2 is a direct target of C/EBPβ. Translocation of C/EBPβ into the nucleus, which was achieved by using a system utilizing the fusion protein between C/EBPβ and the ligand-binding domain of the human estrogen receptor (C/EBPβ-ERT), demonstrated the rapid induction of endogenous Id2 expression. In reporter assays, transactivation of the Id2 promoter by C/EBPβ was observed and, among three potential C/EBPβ binding sites found in the 2.3 kb Id2 promoter region, the most proximal element was responsible for the transactivation. Electrophoretic mobility shift assay (EMSA) identified this element as a core sequence to which C/EBPβ binds. Chromatin immunoprecipitation (ChIP) furthermore confirmed the presence of C/EBPβ in the Id2 promoter region. Northern blotting showed that Id2 expression in C/EBPβ-deficient mammary glands was reduced at 10 days post coitus (d.p.c.), compared with that in wild-type mammary glands. Thus, our data demonstrate that Id2 is a direct target of C/EBPβ and provide insight into molecular mechanisms underlying mammary gland development during pregnancy. PMID:15809228

  11. Small molecule inhibitors of USP1 target ID1 degradation in leukemic cells

    PubMed Central

    Mistry, Helena; Hsieh, Grace; Buhrlage, Sara J.; Huang, Min; Park, Eunmi; Cuny, Gregory D.; Galinsky, Ilene; Stone, Richard M; Gray, Nathanael S.; D'Andrea, Alan D.; Parmar, Kalindi

    2013-01-01

    Inhibitor of DNA-binding-1 (ID1) transcription factor is essential for the proliferation and progression of many cancer types including leukemia. However, the ID1 protein has not yet been therapeutically targeted in leukemia. ID1 is normally polyubiquitinated and degraded by the proteasome. Recently, it has been shown that USP1, a ubiquitin specific protease, deubiquitinates ID1 and rescues it from proteasome degradation. Inhibition of USP1 therefore offers a new avenue to target ID1 in cancer. Here, using a Ubiquitin-Rhodamine-based high throughput screening, we identified small molecule inhibitors of USP1 and investigated their therapeutic potential for leukemia. These inhibitors blocked the deubiquitinating enzyme activity of USP1 in vitro in a dose-dependent manner with an IC50 in the high nanomolar range. USP1 inhibitors promoted the degradation of ID1 and, concurrently, inhibited the growth of leukemic cell lines in a dose dependent manner. A known USP1 inhibitor, Pimozide, also promoted ID1 degradation and inhibited growth of leukemic cells. In addition, the growth of primary Acute Myeloid Leukemia (AML) patient-derived leukemic cells was inhibited by a USP1 inhibitor. Collectively, these results indicate that the novel small molecule inhibitors of USP1 promote ID1 degradation and are cytotoxic to leukemic cells. The identification of USP1 inhibitors therefore opens up a new approach for leukemia therapy. PMID:24130053

  12. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3.

    PubMed

    Rivera, R R; Johns, C P; Quan, J; Johnson, R S; Murre, C

    2000-01-01

    E2A, HEB, E2-2, and daughterless are basic helix-loop-helix (bHLH) proteins that play key roles in multiple developmental pathways. The DNA binding activity of E2A, HEB, and E2-2 is regulated by a distinct class of inhibitor HLH proteins, the Id gene products. Here, we show that Id3 is required for major histocompatability (MHC) class I- and class II-restricted thymocyte positive selection. Additionally, H-Y TCR-mediated negative selection is severely perturbed in Id3 null mutant mice. Finally, we show that E2A and Id3 interact genetically to regulate thymocyte development. These observations identify the HLH inhibitory protein Id3 as an essential component required for proper thymocyte maturation. PMID:10661402

  13. ID Proteins Regulate Diverse Aspects of Cancer Progression and Provide Novel Therapeutic Opportunities

    PubMed Central

    Nair, Radhika; Teo, Wee Siang; Mittal, Vivek; Swarbrick, Alexander

    2014-01-01

    The inhibitor of differentiation (ID) proteins are helix-loop-helix transcriptional repressors with established roles in stem cell self-renewal, lineage commitment, and niche interactions. While deregulated expression of ID proteins in cancer was identified more than a decade ago, emerging evidence has revealed a central role for ID proteins in neoplastic progression of multiple tumor types that often mirrors their function in physiological stem and progenitor cells. ID proteins are required for the maintenance of cancer stem cells, self-renewal, and proliferation in a range of malignancies. Furthermore, ID proteins promote metastatic dissemination through their role in remodeling the tumor microenvironment and by promoting tumor-associated endothelial progenitor cell proliferation and mobilization. Here, we discuss the latest findings in this area and the clinical opportunities that they provide. PMID:24827908

  14. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.

    PubMed

    McAllister, Sean D; Christian, Rigel T; Horowitz, Maxx P; Garcia, Amaia; Desprez, Pierre-Yves

    2007-11-01

    Invasion and metastasis of aggressive breast cancer cells is the final and fatal step during cancer progression, and is the least understood genetically. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available. Clearly, effective and nontoxic therapies are urgently required. Id-1, an inhibitor of basic helix-loop-helix transcription factors, has recently been shown to be a key regulator of the metastatic potential of breast and additional cancers. Using a mouse model, we previously determined that metastatic breast cancer cells became significantly less invasive in vitro and less metastatic in vivo when Id-1 was down-regulated by stable transduction with antisense Id-1. It is not possible at this point, however, to use antisense technology to reduce Id-1 expression in patients with metastatic breast cancer. Here, we report that cannabidiol (CBD), a cannabinoid with a low-toxicity profile, could down-regulate Id-1 expression in aggressive human breast cancer cells. The CBD concentrations effective at inhibiting Id-1 expression correlated with those used to inhibit the proliferative and invasive phenotype of breast cancer cells. CBD was able to inhibit Id-1 expression at the mRNA and protein level in a concentration-dependent fashion. These effects seemed to occur as the result of an inhibition of the Id-1 gene at the promoter level. Importantly, CBD did not inhibit invasiveness in cells that ectopically expressed Id-1. In conclusion, CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness. PMID:18025276

  15. Mono County geothermal activity

    SciTech Connect

    Lyster, D.L.

    1986-01-01

    Three geothermal projects have been proposed or are underway in Mono County, California. The Mammoth/Chance geothermal development project plans to construct a 10-MW geothermal binary power plant which will include 8 production and 3 injection wells. Pacific Lighting Energy Systems is also planning a 10-MW binary power plant consisting of 5 geothermal wells and up to 4 injection wells. A geothermal research project near Mammoth Lakes has spudded a well to provide a way to periodically measure temperature gradient, pressure, and chemistry of the thermal waters and to investigate the space-heating potential of the area in the vicinity of Mammoth Lakes. All three projects are briefly described.

  16. Molecular characterization of lactobacilli isolated from fermented idli batter

    PubMed Central

    Agaliya, Perumal Jayaprabha; Jeevaratnam, Kadirvelu

    2013-01-01

    Lactic acid bacteria are non pathogenic organism widely distributed in nature typically involved in a large number of spontaneous food fermentation. The purpose of this study was to characterize the bacteriocinogenic lactobacilli from fermented idli batter which can find application in biopreservation and biomedicine. Eight most promising lactobacilli were chosen from twenty two isolates based on their spectrum of activity against other lactic acid bacteria and pathogens. The eight lactobacilli were characterized based on the various classical phenotypic tests, physiological tests and biochemical tests including various carbohydrate utilization profiles. All isolates were homo fermentative, catalase, and gelatin negative. Molecular characterization was performed by RAPD, 16S rRNA analysis, 16S ARDRA, and Multiplex PCR for species identification. RAPD was carried out using the primer R2 and M13. Five different clusters were obtained based on RAPD indicating strain level variation. 16S rRNA analysis showed 99 to 100% homology towards Lactobacillus plantarum. The restriction digestion pattern was similar for all the isolates with the restriction enzyme AluI. The subspecies were identified by performing Multiplex PCR using species specific primer. Among the five clusters, three clusters were clearly identified as Lactobacillus plantarum subsp. plantarum, Lactobacillus pentosus, and Lactobacillus plantarum subsp. argentoratensis. PMID:24688512

  17. A neural-visualization IDS for honeynet data.

    PubMed

    Herrero, lvaro; Zurutuza, Urko; Corchado, Emilio

    2012-04-01

    Neural intelligent systems can provide a visualization of the network traffic for security staff, in order to reduce the widely known high false-positive rate associated with misuse-based Intrusion Detection Systems (IDSs). Unlike previous work, this study proposes an unsupervised neural models that generate an intuitive visualization of the captured traffic, rather than network statistics. These snapshots of network events are immensely useful for security personnel that monitor network behavior. The system is based on the use of different neural projection and unsupervised methods for the visual inspection of honeypot data, and may be seen as a complementary network security tool that sheds light on internal data structures through visual inspection of the traffic itself. Furthermore, it is intended to facilitate verification and assessment of Snort performance (a well-known and widely-used misuse-based IDS), through the visualization of attack patterns. Empirical verification and comparison of the proposed projection methods are performed in a real domain, where two different case studies are defined and analyzed. PMID:23627591

  18. Comparison of ID performance using real and synthetic imagery

    NASA Astrophysics Data System (ADS)

    Jacobs, Eddie L.; Edwards, Timothy C.; Miller, Brian; Hodgkin, Van A.

    2002-07-01

    Recent experiments performed at the U.S. Army Night Vision and Electronic Sensors Directorate (NVESD) provide significant insight into the validation of synthetic imagery for use in human perception experiments. This paper documents the procedures and results of target identification (ID) experiments using real and synthetic thermal imagery. Real imagery representing notional first generation and advanced scanning sensor systems was obtained. Parameters derived from the sensor data were used to generate synthetic imagery using the NVESD Paint the Night simulation. Both image sets were then used in a target identification experiment with trained human observers. Perception test results were analyzed and compared with metrics derived from the imagery. Several parameters missing from the original truth data were found to correlate with differences in the perception data. Synthetic data were regenerated using these additional parameters. A subsequent perception experiment confirmed the importance of these parameters, and a good match was obtained between real and synthetic imagery. While the techniques used in this series of experiments do not constitute a definitive method for validating synthetic imagery, they point to some important observations on validation. The main observation is that both target and local background characteristics must be sufficiently specified in the truth data in order to obtain good agreement between synthetic and real data. The paper concludes with suggestions as to the level of detail necessary for truth data when using synthetic imagery in perception experiments.

  19. Minimum wafer thickness by rotated ingot ID wafering. [Inner Diameter

    NASA Technical Reports Server (NTRS)

    Chen, C. P.; Leipold, M. H.

    1984-01-01

    The efficient utilization of materials is critical to certain device applications such as silicon for photovoltaics or diodes and gallium-gadolinium-garnet for memories. A variety of slicing techniques has been investigated to minimize wafer thickness and wafer kerf. This paper presents the results of analyses of ID wafering of rotated ingots based on predicted fracture behavior of the wafer as a result of forces during wafering and the properties of the device material. The analytical model indicated that the minimum wafer thickness is controlled by the depth of surface damage and the applied cantilever force. Both of these factors should be minimized. For silicon, a minimum thickness was found to be approximately 200 x 10 - 6th m for conventional sizes of rotated ingot wafering. Fractures through the thickness of the wafer rather than through the center supporting column were found to limit the minimum wafer thickness. The model suggested that the use of a vacuum chuck on the wafer surface to enhance cleavage fracture of the center supporting core and, with silicon, by using 111-line-type ingots could have potential for reducing minimum wafer thickness.

  20. Vision robot with rotational camera for searching ID tags

    NASA Astrophysics Data System (ADS)

    Kimura, Nobutaka; Moriya, Toshio

    2008-02-01

    We propose a new concept, called "real world crawling", in which intelligent mobile sensors completely recognize environments by actively gathering information in those environments and integrating that information on the basis of location. First we locate objects by widely and roughly scanning the entire environment with these mobile sensors, and we check the objects in detail by moving the sensors to find out exactly what and where they are. We focused on the automation of inventory counting with barcodes as an application of our concept. We developed "a barcode reading robot" which autonomously moved in a warehouse. It located and read barcode ID tags using a camera and a barcode reader while moving. However, motion blurs caused by the robot's translational motion made it difficult to recognize the barcodes. Because of the high computational cost of image deblurring software, we used the pan rotation of the camera to reduce these blurs. We derived the appropriate pan rotation velocity from the robot's translational velocity and from the distance to the surfaces of barcoded boxes. We verified the effectiveness of our method in an experimental test.

  1. Pros and Cons of ID vs. 3D Modeling

    NASA Technical Reports Server (NTRS)

    Klimchuk, James A.

    2012-01-01

    Advances in computing capability have led to tremendous improvements in 3D modeling. Entire active regions are being simulated in what might be described as a first principles way, in which plasma heating is treated self consistently rather than through the specification of heating functions. There are limitations to this approach, however, as actual heating mechanisms on the Sun involve spatial scales orders of magnitude smaller than what these simulations can resolve. Other simulations begin to resolve these scales, but they only treat a tiny volume and do not include the all important coupling with larger scales or with other parts of the atmosphere, and so cannot be readily compared with observations. Finally, ID hydrodynamic models capture the field-aligned evolution of the plasma extremely well and are ideally suited for data comparison, but they treat the heating in a totally ad hoc manner. All of these approaches have important contributions to make, but we must be aware of their limitations. I will highlight some of the strengths. and weaknesses of each.

  2. High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells

    PubMed Central

    Nam, Hyung-song; Benezra, Robert

    2009-01-01

    Defining the molecular identity of stem cells may be critical for formulating a rational strategy for the therapeutic intervention of stem cell dysfunction. We find that high expression of Id1, a dominant-negative helix-loop-helix transcriptional regulator, identifies a rare population GFAP+ astrocytes with stem cell attributes among the subventricular astrocytes in the adult brain. The rare, long-lived, and relatively quiescent Id1high astrocytes with morphology characteristic of B1 type astrocytes self-renew and generate migratory neuroblasts that differentiate into olfactory bulb interneurons. Cultured Id1high neural stem cells can self-renew asymmetrically and generate a stem and a differentiated cell expressing progressively lower levels of Id1, revealing an Id1 gradient in unperturbed cells of subventricular neurogenic lineages. Moreover, Id genes are necessary to confer self-renewal capacity, a characteristic of stem cell identity. We suggest that high expression of a single transcriptional regulator, Id1, molecularly defines the long-sought-after B1 type adult neural stem cells. PMID:19896442

  3. ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2.

    PubMed

    Ghosh, Hiyaa S; Ceribelli, Michele; Matos, Ines; Lazarovici, Allan; Bussemaker, Harmen J; Lasorella, Anna; Hiebert, Scott W; Liu, Kang; Staudt, Louis M; Reizis, Boris

    2014-07-28

    Dendritic cells (DCs) comprise two major subsets, the interferon (IFN)-producing plasmacytoid DCs (pDCs) and antigen-presenting classical DCs (cDCs). The development of pDCs is promoted by E protein transcription factor E2-2, whereas E protein antagonist Id2 is specifically absent from pDCs. Conversely, Id2 is prominently expressed in cDCs and promotes CD8(+) cDC development. The mechanisms that control the balance between E and Id proteins during DC subset specification remain unknown. We found that the loss of Mtg16, a transcriptional cofactor of the ETO protein family, profoundly impaired pDC development and pDC-dependent IFN response. The residual Mtg16-deficient pDCs showed aberrant phenotype, including the expression of myeloid marker CD11b. Conversely, the development of cDC progenitors (pre-DCs) and of CD8(+) cDCs was enhanced. Genome-wide expression and DNA-binding analysis identified Id2 as a direct target of Mtg16. Mtg16-deficient cDC progenitors and pDCs showed aberrant induction of Id2, and the deletion of Id2 facilitated the impaired development of Mtg16-deficient pDCs. Thus, Mtg16 promotes pDC differentiation and restricts cDC development in part by repressing Id2, revealing a cell-intrinsic mechanism that controls subset balance during DC development. PMID:24980046

  4. SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers.

    PubMed

    Hass, Matthew R; Liow, Hien-Haw; Chen, Xiaoting; Sharma, Ankur; Inoue, Yukiko U; Inoue, Takayoshi; Reeb, Ashley; Martens, Andrew; Fulbright, Mary; Raju, Saravanan; Stevens, Michael; Boyle, Scott; Park, Joo-Seop; Weirauch, Matthew T; Brent, Michael R; Kopan, Raphael

    2015-08-20

    We developed Split DamID (SpDamID), a protein complementation version of DamID, to mark genomic DNA bound in vivo by interacting or juxtapositioned transcription factors. Inactive halves of DAM (DNA adenine methyltransferase) were fused to protein pairs to be queried. Either direct interaction between proteins or proximity enabled DAM reconstitution and methylation of adenine in GATC. Inducible SpDamID was used to analyze Notch-mediated transcriptional activation. We demonstrate that Notch complexes label RBP sites broadly across the genome and show that a subset of these complexes that recruit MAML and p300 undergo changes in chromatin accessibility in response to Notch signaling. SpDamID differentiates between monomeric and dimeric binding, thereby allowing for identification of half-site motifs used by Notch dimers. Motif enrichment of Notch enhancers coupled with SpDamID reveals co-targeting of regulatory sequences by Notch and Runx1. SpDamID represents a sensitive and powerful tool that enables dynamic analysis of combinatorial protein-DNA transactions at a genome-wide level. PMID:26257285

  5. Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis

    PubMed Central

    Niola, Francesco; Zhao, Xudong; Singh, Devendra; Sullivan, Ryan; Castano, Angelica; Verrico, Antonio; Zoppoli, Pietro; Friedmann-Morvinski, Dinorah; Sulman, Erik; Barrett, Lindy; Zhuang, Yuan; Verma, Inder; Benezra, Robert; Aldape, Ken; Iavarone, Antonio; Lasorella, Anna

    2012-01-01

    High-grade gliomas (HGGs) are incurable brain tumors that are characterized by the presence of glioma-initiating cells (GICs). GICs are essential to tumor aggressiveness and retain the capacity for self-renewal and multilineage differentiation as long as they reside in the perivascular niche. ID proteins are master regulators of stemness and anchorage to the extracellular niche microenvironment, suggesting that they may play a role in maintaining GICs. Here, we modeled the probable therapeutic impact of ID inactivation in HGG by selective ablation of Id in tumor cells and after tumor initiation in a new mouse model of human mesenchymal HGG. Deletion of 3 Id genes induced rapid release of GICs from the perivascular niche, followed by tumor regression. GIC displacement was mediated by derepression of Rap1gap and subsequent inhibition of RAP1, a master regulator of cell adhesion. We identified a signature module of 5 genes in the ID pathway, including RAP1GAP, which segregated 2 subgroups of glioma patients with markedly different clinical outcomes. The model-informed survival analysis together with genetic and functional studies establish that ID activity is required for the maintenance of mesenchymal HGG and suggest that pharmacological inactivation of ID proteins could serve as a therapeutic strategy. PMID:23241957

  6. The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues

    SciTech Connect

    Kurooka, Hisanori; Research and Education Program for Life Science, University of Fukui, Fukui ; Sugai, Manabu; Mori, Kentaro; Yokota, Yoshifumi; Research and Education Program for Life Science, University of Fukui, Fukui

    2013-04-19

    Highlights: •Sodium arsenite induces cytoplasmic accumulation of Id3. •Arsenite binds to closely spaced N-terminal cysteine residues of Id3. •N-terminal cysteines are essential for arsenite-induced nuclear export of Id3. •Nuclear export of Id3 counteracts its transcriptional repression activity. -- Abstract: Ids are versatile transcriptional repressors that regulate cell proliferation and differentiation, and appropriate subcellular localization of the Id proteins is important for their functions. We previously identified distinct functional nuclear export signals (NESs) in Id1 and Id2, but no active NES has been reported in Id3. In this study, we found that treatment with the stress-inducing metalloid arsenite led to the accumulation of GFP-tagged Id3 in the cytoplasm. Cytoplasmic accumulation was impaired by a mutation in the Id3 NES-like sequence resembling the Id1 NES, located at the end of the HLH domain. It was also blocked by co-treatment with the CRM1-specific nuclear export inhibitor leptomycin B (LMB), but not with the inhibitors for mitogen-activated protein kinases (MAPKs). Importantly, we showed that the closely spaced N-terminal cysteine residues of Id3 interacted with the arsenic derivative phenylarsine oxide (PAO) and were essential for the arsenite-induced cytoplasmic accumulation, suggesting that arsenite induces the CRM1-dependent nuclear export of Id3 via binding to the N-terminal cysteines. Finally, we demonstrated that Id3 significantly repressed arsenite-stimulated transcription of the immediate-early gene Egr-1 and that this repression activity was inversely correlated with the arsenite-induced nuclear export. Our results imply that Id3 may be involved in the biological action of arsenite.

  7. Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma

    DOEpatents

    Desprez, Pierre-Yves; Campisi, Judith

    2014-08-19

    A method for treatment of breast cancer and other types of cancer. The method comprises targeting and modulating Id-1 gene expression, if any, for the Id-1 gene, or gene products in breast or other epithelial cancers in a patient by delivering products that modulate Id-1 gene expression. When expressed, Id-1 gene is a prognostic indicator that cancer cells are invasive and metastatic.

  8. Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation

    PubMed Central

    Jin, Rong; Tang, Hui; Liu, Yuan-Feng; Ge, Qing; Sun, Xiao-Hong; Zhang, Yu

    2014-01-01

    T Regulatory cells (Treg) play crucial roles in the regulation of cellular immunity. The development of Treg cells depends on signals from T cell receptors (TCR) and IL-2 receptors and is influenced by a variety of transcription factors. The basic helix-loop-helix (bHLH) proteins are known to influence TCR signaling thresholds. Whether this property impacts Treg differentiation is not understood. Here, we interrogated the role of bHLH proteins in the production of Treg cells using the CD4 promoter-driven Id1 transgene. We found that Treg cells continued to accumulate as Id1 transgenic mice aged, resulting in a significant increase in Treg cell counts in the thymus as well as in the periphery compared to wild type controls. Data from mixed-bone marrow assays suggest that Id1 acts intrinsically on developing Treg cells. We made a connection between Id1 expression and CD28 co-stimulatory signaling because Id1 transgene expression facilitated the formation of Treg precursors in CD28−/− mice and the in vitro differentiation of Treg cells on thymic dendritic cells despite the blockade of costimulation by anti-CD80/CD86. Id1 expression also allowed in vitro Treg differentiation without anti-CD28 co-stimulation, which was at least in part due to enhanced production of IL-2. Notably, with full strength of co-stimulatory signals, however, Id1 expression caused modest but significant suppression of Treg induction. Finally, we demonstrate that Id1 transgenic mice were less susceptible to the induction of experimental autoimmune encephalomyelitis (EAE), thus illustrating the impact of Id1-mediated augmentation of Treg cell levels on cellular immunity. PMID:24920844

  9. Family Impact in Intellectual Disability, Severe Mental Health Disorders and Mental Health Disorders in ID. A Comparison

    ERIC Educational Resources Information Center

    Martorell, Almudena; Gutierrez-Recacha, Pedro; Irazabal, Marcia; Marsa, Ferran; Garcia, Mercedes

    2011-01-01

    Family impact (or family burden) is a concept born in the field of mental health that has successfully been exported to the ambit of intellectual disability (ID). However, differences in family impact associated with severe mental health disorders (schizophrenia), to ID or to mental health problems in ID should be expected. Seventy-two adults with

  10. Family Impact in Intellectual Disability, Severe Mental Health Disorders and Mental Health Disorders in ID. A Comparison

    ERIC Educational Resources Information Center

    Martorell, Almudena; Gutierrez-Recacha, Pedro; Irazabal, Marcia; Marsa, Ferran; Garcia, Mercedes

    2011-01-01

    Family impact (or family burden) is a concept born in the field of mental health that has successfully been exported to the ambit of intellectual disability (ID). However, differences in family impact associated with severe mental health disorders (schizophrenia), to ID or to mental health problems in ID should be expected. Seventy-two adults with…

  11. Wnt/{beta}-catenin signaling changes C2C12 myoblast proliferation and differentiation by inducing Id3 expression

    SciTech Connect

    Zhang, Long; Shi, Songting; Zhang, Juan; Zhou, Fangfang; Dijke, Peter ten

    2012-03-02

    Highlights: Black-Right-Pointing-Pointer Expression of Id3 but not Id1 is induced by Wnt3a stimulation in C2C12 cells. Black-Right-Pointing-Pointer Wnt3a induces Id3 expression via canonical Wnt/{beta}-catenin pathway. Black-Right-Pointing-Pointer Wnt3a-induced Id3 expression does not depend on BMP signaling activation. Black-Right-Pointing-Pointer Induction of Id3 expression is critical determinant in Wnt3a-induced cell proliferation and differentiation. -- Abstract: Canonical Wnt signaling plays important roles in regulating cell proliferation and differentiation. In this study, we report that inhibitor of differentiation (Id)3 is a Wnt-inducible gene in mouse C2C12 myoblasts. Wnt3a induced Id3 expression in a {beta}-catenin-dependent manner. Bone morphogenetic protein (BMP) also potently induced Id3 expression. However, Wnt-induced Id3 expression occurred independent of the BMP/Smad pathway. Functional studies showed that Id3 depletion in C2C12 cells impaired Wnt3a-induced cell proliferation and alkaline phosphatase activity, an early marker of osteoblast cells. Id3 depletion elevated myogenin induction during myogenic differentiation and partially impaired Wnt3a suppressed myogenin expression in C2C12 cells. These results suggest that Id3 is an important Wnt/{beta}-catenin induced gene in myoblast cell fate determination.

  12. Hydrology of Polk County, Florida

    USGS Publications Warehouse

    Spechler, Rick M.; Kroening, Sharon E.

    2007-01-01

    Local water managers usually rely on information produced at the State and regional scale to make water-resource management decisions. Current assessments of hydrologic and water-quality conditions in Polk County, Florida, commonly end at the boundaries of two water management districts (South Florida Water Management District and the Southwest Florida Water Management District), which makes it difficult for managers to determine conditions throughout the county. The last comprehensive water-resources assessment of Polk County was published almost 40 years ago. To address the need for current countywide information, the U.S. Geological Survey began a 3?-year study in 2002 to update information about hydrologic and water-quality conditions in Polk County and identify changes that have occurred. Ground-water use in Polk County has decreased substantially since 1965. In 1965, total ground-water withdrawals in the county were about 350 million gallons per day. In 2002, withdrawals totaled about 285 million gallons per day, of which nearly 95 percent was from the Floridan aquifer system. Water-conservation practices mainly related to the phosphate-mining industry as well as the decrease in the number of mines in operation in Polk County have reduced total water use by about 65 million gallons per day since 1965. Polk County is underlain by three principal hydrogeologic units. The uppermost water-bearing unit is the surficial aquifer system, which is unconfined and composed primarily of clastic deposits. The surficial aquifer system is underlain by the intermediate confining unit, which grades into the intermediate aquifer system and consists of up to two water-bearing zones composed of interbedded clastic and carbonate rocks. The lowermost hydrogeologic unit is the Floridan aquifer system. The Floridan aquifer system, a thick sequence of permeable limestone and dolostone, consists of the Upper Floridan aquifer, a middle semiconfining unit, a middle confining unit, and the Lower Floridan aquifer. The Upper Floridan aquifer provides most of the water required to meet demand in Polk County. Data from about 300 geophysical and geologic logs were used to construct hydrogeologic maps showing the tops and thicknesses of the aquifers and confining units within Polk County. Thickness of the surficial aquifer system ranges from several feet thick or less in the extreme northwestern part of the county and along parts of the Peace River south of Bartow to more than 200 feet along the southern part of the Lake Wales Ridge in eastern Polk County. Thickness of the intermediate aquifer system/intermediate confining unit is highly variable throughout the county because of past erosional processes and sinkhole formation. Thickness of the unit ranges from less than 25 feet in the extreme northwestern part of the county to more than 300 feet in southwestern Polk County. The altitude of the top of the Upper Floridan aquifer in the county ranges from about 50 feet above National Geodetic Vertical Datum of 1929 (NGVD 29) in the northwestern part to more than 250 feet below NGVD 29 in the southern part. Water levels in the Upper Floridan aquifer fluctuate seasonally, increasing during the wet season (June through September) and decreasing during the rest of the year. Water levels in the Upper Floridan aquifer also can change from year to year, depending on such factors as pumpage and climatic variations. In the southwestern part of the county, fluctuations in water use related to phosphate mining have had a major impact on ground-water levels. Hydrographs of selected wells in southwestern Polk County show a general decline in water levels that ended in the mid-1970s. This water-level decline coincides with an increase in water use associated with phosphate mining. A substantial increase in water levels that began in the mid-1970s coincides with a period of decreasing water use in the county. Despite reductions in water use since 1970, howev

  13. Unconventional myosin ID is expressed in myelinating oligodendrocytes.

    PubMed

    Yamazaki, Reiji; Ishibashi, Tomoko; Baba, Hiroko; Yamaguchi, Yoshihide

    2014-10-01

    Myelin is a dynamic multilamellar structure that ensheathes axons and is crucial for normal neuronal function. In the central nervous system (CNS), myelin is produced by oligodendrocytes that wrap many layers of plasma membrane around axons. The dynamic membrane trafficking system, which relies on motor proteins, is required for myelin formation and maintenance. Previously, we found that myosin ID (Myo1d), a class I myosin, is enriched in the rat CNS myelin fraction. Myo1d is an unconventional myosin and has been shown to be involved in membrane trafficking in the recycling pathway in an epithelial cell line. Western blotting revealed that Myo1d expression begins early in myelinogenesis and continues to increase into adulthood. The localization of Myo1d in CNS myelin has not been reported, and the function of Myo1d in vivo remains unknown. To demonstrate the expression of Myo1d in CNS myelin and to begin to explore the function of Myo1d in myelination, we produced a new antibody against Myo1d that has a high titer and specificity for rat Myo1d. By using this antibody, we demonstrated that Myo1d is expressed in rat CNS myelin and is especially abundant in abaxonal and adaxonal regions (the outer and inner cytoplasm-containing loops, respectively), but that expression is low in peripheral nervous system myelin. In culture, Myo1d was expressed in mature rat oligodendrocytes. Furthermore, an increase in expression of Myo1d during maturation of CNS white matter (cerebellum and corpus callosum) was demonstrated by histological analysis. These results suggest that Myo1d may be involved in the formation and/or maintenance of CNS myelin. PMID:24903835

  14. Long-range optical character recognition for product ID

    NASA Astrophysics Data System (ADS)

    Banta, Larry E.; Pertl, Franz A.; Rosenberry-Friend, Kimberly A.

    1998-10-01

    An automated product tag reading system based on CCD cameras and computer image processing has been developed by West Virginia University and demonstrated at the Weirton Steel Corporation. The system reads both a 50-mil barcode and a string of six numbers on a four-inch by six-inch tag fastened to the end of a steel slab. Feedback from the image is used to point and zoom the camera, making the system effective at ranges up to thirty feet, and in bright sunlight-situations where handheld barcode scanners are ineffective. A video camera is mounted on a pan/tilt head and connected to a personal computer through a frame grabber board. The whole system is mounted on a slab hauler--a huge wheeled machine for carrying 100 tons of steel slabs at a time. The slab hauler backs into position and presses `start' on a touchscreen operator interface. A wide-angle image is grabbed, and the computer analyzes the images to find product ID tags in scene. The camera is then zoomed and pointed one-by-one at the tags for closeup images. Geometric warping is done on the closeup images to correct for viewing angle distortion, and both the barcode and the alphanumeric code are read by the software and reported to the inventory management system via radio modern. This paper discusses the neural network-based system for reading the characters on the tag. The camera pointing system and barcode reader are discussed in a companion paper.

  15. The regulation and function of the Id proteins in lymphocyte development.

    PubMed

    Rivera, R; Murre, C

    2001-12-20

    Helix-loop-helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation, survival, proliferation, and differentiation. E-proteins are negatively regulated by another class of HLH proteins known as the Id proteins. The Id proteins function as dominant negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here we discuss the function and regulation of the Id proteins in lymphocyte development. PMID:11840323

  16. Improvement and analysis of ID3 algorithm in decision-making tree

    NASA Astrophysics Data System (ADS)

    Xie, Xiao-Lan; Long, Zhen; Liao, Wen-Qi

    2015-12-01

    For the cooperative system under development, it needs to use the spatial analysis and relative technology concerning data mining in order to carry out the detection of the subject conflict and redundancy, while the ID3 algorithm is an important data mining. Due to the traditional ID3 algorithm in the decision-making tree towards the log part is rather complicated, this paper obtained a new computational formula of information gain through the optimization of algorithm of the log part. During the experiment contrast and theoretical analysis, it is found that IID3 (Improved ID3 Algorithm) algorithm owns higher calculation efficiency and accuracy and thus worth popularizing.

  17. 78 FR 68467 - Notice of Public Meetings, Twin Falls District Resource Advisory Council, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ... Resource Advisory Council (RAC) and subcommittee for the Greater sage-grouse will meet as indicated below... sage-grouse will meet at the Twin Falls District BLM Office, 2536 Kimberly Road, Twin Falls, ID...

  18. 75 FR 15741 - Applied Materials; Boise, ID; Notice of Termination of Investigation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Applied Materials; Boise, ID; Notice of Termination of Investigation... Officer, Division of Trade Adjustment Assistance. BILLING CODE 4510-FN-P...

  19. How to save distressed IDS-physician marriages: a case study.

    PubMed

    Collins, H; Johnson, B A

    1998-04-01

    A hospital-driven IDS that encounters serious problems resulting from ownership of a physician practice should address those problems by focusing on three core areas: vision and leadership, effectiveness of operations, and physician compensation arrangements. If changes in these areas do not lead to improvements, the IDS may need to consider organizational restructuring. In one case study, a hospital-driven IDS faced the problem of owning a poorly performing MSO with a captive physician group. The IDS's governing board determined that the organization lacked effective communication with the physicians and that realization of the organization's vision would require greater physician involvement in organizational decision making. The organization is expected to undergo some corporate reorganization in which physicians will acquire an equity interest in the enterprise. PMID:10178061

  20. Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-beta.

    PubMed

    Kee, B L; Rivera, R R; Murre, C

    2001-03-01

    E proteins function in many developmental processes and are essential for the formation of lymphocyte progenitors. However, it is not known whether E proteins regulate lymphocyte survival, proliferation or differentiation or how their activity is regulated during lymphocyte development. We show here a role for Id3, an inhibitor of E protein activity, in the induction of apoptosis and growth arrest. Id3 is induced in response to transforming growth factor beta (TGF-beta), a pleiotropic cytokine that inhibits the growth and survival of normal and transformed lymphocyte progenitors. In the absence of Id3, the response of lymphocyte progenitors to TGF-beta is perturbed, which indicates that Id3 is a mediator of this response. Our data show a key role for E proteins in lymphocyte survival and link the activity of E proteins, and their antagonists, to members of the TGF-beta family of cytokines. PMID:11224524

  1. 17 CFR 249.446 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...: For Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears... has been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent...

  2. 17 CFR 274.402 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... its Password. Editorial Note: For Federal Register citations affecting Form ID, see the List of CFR... filer to ensure that the filing has been authorized by the filer. (c) Password (PW)allows a...

  3. 17 CFR 274.402 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... its Password. Editorial Note: For Federal Register citations affecting Form ID, see the List of CFR... filer to ensure that the filing has been authorized by the filer. (c) Password (PW)allows a...

  4. 17 CFR 239.63 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...: For Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears... has been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent...

  5. 17 CFR 249.446 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...: For Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears... has been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent...

  6. 17 CFR 274.402 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... its Password. Editorial Note: For Federal Register citations affecting Form ID, see the List of CFR... filer to ensure that the filing has been authorized by the filer. (c) Password (PW)allows a...

  7. 17 CFR 249.446 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...: For Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears... has been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent...

  8. 17 CFR 249.446 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...: For Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears... has been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent...

  9. 17 CFR 269.7 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears in the... been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent to...

  10. 17 CFR 269.7 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears in the... been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent to...

  11. 17 CFR 239.63 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...: For Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears... has been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent...

  12. 17 CFR 274.402 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... its Password. Editorial Note: For Federal Register citations affecting Form ID, see the List of CFR... filer to ensure that the filing has been authorized by the filer. (c) Password (PW)allows a...

  13. 17 CFR 249.446 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...: For Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears... has been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent...

  14. 17 CFR 269.7 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears in the... been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent to...

  15. 17 CFR 239.63 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...: For Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears... has been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent...

  16. 17 CFR 269.7 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears in the... been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent to...

  17. 17 CFR 274.402 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... its Password. Editorial Note: For Federal Register citations affecting Form ID, see the List of CFR... filer to ensure that the filing has been authorized by the filer. (c) Password (PW)allows a...

  18. 17 CFR 239.63 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...: For Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears... has been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent...

  19. 17 CFR 269.7 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears in the... been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent to...

  20. 17 CFR 239.63 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...: For Federal Register citations affecting Form ID, see the List of CFR Sections Affected, which appears... has been authorized by the filer. (c) Password (PW)allows a filer, filing agent or training agent...

  1. Id2 IS REQUIRED FOR SPECIFICATION OF DOPAMINERGIC NEURONS DURING ADULT OLFACTORY NEUROGENESIS

    PubMed Central

    Havrda, Matthew C.; Harris, Brent T.; Mantani, Akio; Ward, Nora M.; Paolella, Brenton R.; Cuzon, Verginia C.; Yeh, Hermes H.; Israel, Mark A.

    2009-01-01

    Understanding the biology of adult neural stem cells has important implications for nervous system development and may contribute to our understanding of neurodegenerative disorders and their treatment. We have characterized the process of olfactory neurogenesis in adult mice lacking Inhibitor of DNA Binding 2 (Id2). We found a diminished olfactory bulb containing reduced numbers of granular and periglomerular neurons with a distinct paucity of dopaminergic periglomerular neurons. While no deficiency of the stem cell compartment was detectable, migrating neuroblasts in Id2−/− mutant mice prematurely undergo astroglial differentiation within a disorganized rostral migratory stream. Further, when evaluated in vitro loss of Id2 results in decreased proliferation of neural progenitors and decreased expression of the Hes1 and Mash1 transcription factors, known mediators of neuronal differentiation. These data support a novel role for sustained Id2 expression in migrating neural progenitors mediating olfactory dopaminergic neuronal differentiation in adult animals. PMID:19109490

  2. Tennessee Higher Education County Profiles, 2008

    ERIC Educational Resources Information Center

    Tennessee Higher Education Commission, 2008

    2008-01-01

    This report presents a localized perspective on Tennessee higher education, including: (1) county demographic and economic data; (2) information on public and private colleges and universities located in the county; (3) number of county residents enrolled in Tennessee public institutions; and (4) number of county residents participating in the…

  3. 75 FR 22100 - Nevada County and Placer County, CA, Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... Forest Service Nevada County and Placer County, CA, Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Nevada County and Placer County Resource Advisory... National Forests in Nevada and Placer Counties. DATES: The meeting will be held Tuesday, May 4, 2010 at...

  4. The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells.

    PubMed

    Nakatsukasa, Hiroko; Zhang, Dunfang; Maruyama, Takashi; Chen, Hua; Cui, Kairong; Ishikawa, Masaki; Deng, Lisa; Zanvit, Peter; Tu, Eric; Jin, Wenwen; Abbatiello, Brittany; Goldberg, Nathan; Chen, Qianming; Sun, Lingyun; Zhao, Keji; Chen, WanJun

    2015-10-01

    The molecular mechanisms by which signaling via transforming growth factor-? (TGF-?) and interleukin 4 (IL-4) control the differentiation of CD4(+) IL-9-producing helper T cells (TH9 cells) remain incompletely understood. We found here that the DNA-binding inhibitor Id3 regulated TH9 differentiation, as deletion of Id3 increased IL-9 production from CD4(+) T cells. Mechanistically, TGF-?1 and IL-4 downregulated Id3 expression, and this process required the kinase TAK1. A reduction in Id3 expression enhanced binding of the transcription factors E2A and GATA-3 to the Il9 promoter region, which promoted Il9 transcription. Notably, Id3-mediated control of TH9 differentiation regulated anti-tumor immunity in an experimental melanoma-bearing model in vivo and also in human CD4(+) T cells in vitro. Thus, our study reveals a previously unrecognized TAK1-Id3-E2A-GATA-3 pathway that regulates TH9 differentiation. PMID:26322481

  5. ID box: a multisource attribute data fusion function for target identification

    NASA Astrophysics Data System (ADS)

    Simard, Marc-Alain; Valin, Pierre; Lesage, Frederic

    2000-04-01

    The R&D group at Lockheed-Martin Canada has developed a target identifier function called ID Box. This computer program performs five main functions: first it transforms the sensor attribute input into a few contact ID declarations, second, it evaluates the association score between the contact declarations and the ID propositions of a current target track, third it performs attribute contact to track fusion using a modification of the Dempster-Shafer evidential theory, fourth the ID Box, using a platform library, produces a translator that unifies the information within track identity and the attribute input, and fifth, it manages the distribution of results to a system human computer interface. Our exhaustive platform library enables the ID Box to fuse attribute data from almost all kinds of sensor or information sources that may be found on large warships or patrol aircraft. These attributes are the radar cross section and the moving parts from surveillance radars, allegiance from interrogator systems, emitter composition from electronics support measure systems, spoken language from communication intercept systems, acoustical signature from sonar systems, propulsion types from IR detectors, dimensional data from imaging systems and other classification attributes from various systems or operators including dynamical parameters from positional trackers. This paper presents and describes the ID Box.

  6. Id proteins synchronize stemness and anchorage to the niche of neural stem cells

    PubMed Central

    Niola, Francesco; Zhao, Xudong; Singh, Devendra; Castano, Angelica; Sullivan, Ryan; Lauria, Mario; Nam, Hyung-song; Zhuang, Yuan; Benezra, Robert; Di Bernardo, Diego; Iavarone, Antonio; Lasorella, Anna

    2013-01-01

    Stem-cell functions require activation of stem-cell-intrinsic transcriptional programs and extracellular interaction with a niche microenvironment. How the transcriptional machinery controls residency of stem cells in the niche is unknown. Here we show that Id proteins coordinate stem-cell activities with anchorage of neural stem cells (NSCs) to the niche. Conditional inactivation of three Id genes in NSCs triggered detachment of embryonic and postnatal NSCs from the ventricular and vascular niche, respectively. The interrogation of the gene modules directly targeted by Id deletion in NSCs revealed that Id proteins repress bHLH-mediated activation of Rap1GAP, thus serving to maintain the GTPase activity of RAP1, a key mediator of cell adhesion. Preventing the elevation of the Rap1GAP level countered the consequences of Id loss on NSC–niche interaction and stem-cell identity. Thus, by preserving anchorage of NSCs to the extracellular environment, Id activity synchronizes NSC functions to residency in the specialized niche. PMID:22522171

  7. Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression

    PubMed Central

    Man, Na; Sun, Xiao-Jian; Tan, Yurong; Cao, Marta Garcia; Liu, Fan; Hatlen, Megan; Xu, Haiming; Huang, Gang; Mattlin, Meredith; Mehta, Arpit; Rampersaud, Evadnie; Benezra, Robert; Nimer, Stephen D.

    2015-01-01

    Transcriptional regulators are recurrently altered through translocations, deletions, or aberrant expression in acute myeloid leukemia (AML). Although critically important in leukemogenesis, the underlying pathogenetic mechanisms they trigger remain largely unknown. Here, we identified that Id1 (inhibitor of DNA binding 1) plays a pivotal role in acute myeloid leukemogenesis. Using genetically modified mice, we found that loss of Id1 inhibited t(8;21) leukemia initiation and progression in vivo by abrogating protein kinase B (AKT)1 activation, and that Id1 interacted with AKT1 through its C terminus. An Id1 inhibitor impaired the in vitro growth of AML cells and, when combined with an AKT inhibitor, triggered even greater apoptosis and growth inhibition, whereas normal hematopoietic stem/progenitor cells were largely spared. We then performed in vivo experiments and found that the Id1 inhibitor significantly prolonged the survival of t(8;21)+ leukemic mice, whereas overexpression of activated AKT1 promoted leukemogenesis. Thus, our results establish Id1/Akt1 signaling as a potential therapeutic target in t(8;21) leukemia. PMID:26084673

  8. Inside amber: the structural role of succinic acid in Class Ia and Class Id resinite.

    PubMed

    Poulin, Jennifer; Helwig, Kate

    2014-08-01

    For the first time, molecular evidence of the structural role played by succinic acid within the macromolecular structure of Class Ia and Class Id resinite is presented. Using a novel gas chromatographic methodology, communol (Class Ia) and ozol (Class Id) moieties within the polylabdane matrix are shown to be cross-linked with succinic acid. Samples were analyzed using pyrolysis-gas chromatography-mass spectrometry with in situ hexamethyldisilazane derivatization, using a thermal separation probe to perform the pyrolysis and sample introduction. The relatively slow rate of heating and prolonged pyrolysis of resinites using this new methodology, combined with the use of a mild derivatization reagent, allowed communol pyrolysates from Class Ia resinite and ozol pyrolysates from Class Id resinite to elute with unbroken succinyl ester cross-linkages. These results provide direct molecular evidence that the key role of succinic acid within Class Ia and Class Id resinite is to cross-link the macromolecular structure. In the Class Id resinite, the methodology also allowed the detection of succinyl ester linkages between ozol pyrolysates and dehydroabietol, thus demonstrating that nonpolymerized diterpenes contribute structurally to the macromolecular structure of Class Id resinite. PMID:24945921

  9. Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression.

    PubMed

    Wang, Lan; Man, Na; Sun, Xiao-Jian; Tan, Yurong; Cao, Marta Garcia; Liu, Fan; Hatlen, Megan; Xu, Haiming; Huang, Gang; Mattlin, Meredith; Mehta, Arpit; Rampersaud, Evadnie; Benezra, Robert; Nimer, Stephen D

    2015-07-30

    Transcriptional regulators are recurrently altered through translocations, deletions, or aberrant expression in acute myeloid leukemia (AML). Although critically important in leukemogenesis, the underlying pathogenetic mechanisms they trigger remain largely unknown. Here, we identified that Id1 (inhibitor of DNA binding 1) plays a pivotal role in acute myeloid leukemogenesis. Using genetically modified mice, we found that loss of Id1 inhibited t(8;21) leukemia initiation and progression in vivo by abrogating protein kinase B (AKT)1 activation, and that Id1 interacted with AKT1 through its C terminus. An Id1 inhibitor impaired the in vitro growth of AML cells and, when combined with an AKT inhibitor, triggered even greater apoptosis and growth inhibition, whereas normal hematopoietic stem/progenitor cells were largely spared. We then performed in vivo experiments and found that the Id1 inhibitor significantly prolonged the survival of t(8;21)(+) leukemic mice, whereas overexpression of activated AKT1 promoted leukemogenesis. Thus, our results establish Id1/Akt1 signaling as a potential therapeutic target in t(8;21) leukemia. PMID:26084673

  10. VERMONT COUNTY HEALTH DATA2

    EPA Science Inventory

    This datalayer contains Vermont Population and Health data describing public health (1986-2000), by county, extracted from various sources, such as; the Vermont Department of Health, the Vermont Center for Justice Research, the National Institute on Alcohol Abuse & Alcoholis...

  11. Energy Improvements in Barnstable County

    SciTech Connect

    2003-09-01

    A fact sheet that describes Barnstable County, Massachusetts, effort to improve energy efficiency through a public appliance trade-in program, installation of compact fluorescent light bulbs in public buildings, and public energy education.

  12. Protection against Mycobacterium leprae Infection by the ID83/GLA-SE and ID93/GLA-SE Vaccines Developed for Tuberculosis

    PubMed Central

    Coler, Rhea N.; Laurance, John D.; Sampaio, Lucas H.; Oliveira, Regiane M.; Sousa, Ana Lucia M.; Stefani, Mariane M. A.; Maeda, Yumi; Matsuoka, Masanori; Makino, Masahiko; Reed, Steven G.

    2014-01-01

    Despite the dramatic reduction in the number of leprosy cases worldwide in the 1990s, transmission of the causative agent, Mycobacterium leprae, is still occurring, and new cases continue to appear. New strategies are required in the pursuit of leprosy elimination. The cross-application of vaccines in development for tuberculosis may lead to tools applicable to elimination of leprosy. In this report, we demonstrate that the chimeric fusion proteins ID83 and ID93, developed as antigens for tuberculosis (TB) vaccine candidates, elicited gamma interferon (IFN-?) responses from both TB and paucibacillary (PB) leprosy patients and from healthy household contacts of multibacillary (MB) patients (HHC) but not from nonexposed healthy controls. Immunization of mice with either protein formulated with a Toll-like receptor 4 ligand (TLR4L)-containing adjuvant (glucopyranosyl lipid adjuvant in a stable emulsion [GLA-SE]) stimulated antigen-specific IFN-? secretion from pluripotent Th1 cells. When immunized mice were experimentally infected with M. leprae, both cellular infiltration into the local lymph node and bacterial growth at the site were reduced relative to those of unimmunized mice. Thus, the use of the Mycobacterium tuberculosis candidate vaccines ID83/GLA-SE and ID93/GLA-SE may confer cross-protection against M. leprae infection. Our data suggest these vaccines could potentially be used as an additional control measure for leprosy. PMID:25024362

  13. Geothermal development plan: Yuma county

    SciTech Connect

    White, D.H.

    1981-01-01

    One hot spring and 33 wells drilled in the county discharge water at temperatures sufficient for direct-use geothermal applications such as process heat and space heating and cooling. Currently, one industry within the county has been identified which may be able to use geothermal energy for its process heat requirements. Also, a computer simulation model was used to predict geothermal energy on line as a function of time under both private and city-owned utility development of the resource.

  14. Inhibitor of DNA binding 1 (Id1) induces differentiation and proliferation of mouse embryonic carcinoma P19CL6 cells

    SciTech Connect

    Meng, Qingzhen; Jia, Zhuqing; Wang, Weiping; Li, Binhong; Ma, Kangtao; Zhou, Chunyan

    2011-08-26

    Highlights: {yields} Id1 was upregulated during the cardiac differentiation process of P19CL6 cells. {yields} Id1 upregulated expression of cardiac specific genes Gata4, {alpha}-MHC and ISL1. {yields} Id1 promoted proliferation of P19CL6 cells. {yields} Overexpression of Id1 increased activity of TOP flash. {yields} Wnt3a or LiCl treatment promoted Id1 expression in P19CL6 cells. -- Abstract: The inhibitor of DNA binding (Id) family of genes encodes negative regulators of basic helix-loop-helix transcription factors and has been implicated in such diverse cellular processes as differentiation, proliferation, apoptosis and migration. Id knockout mouse embryos display multiple cardiac defects but the specific role of Id1 in cardiac differentiation is unclear. In the present study, we investigated the function of Id1 in DMSO-induced P19CL6 cells, a widely-accepted cell model of cardiac differentiation. We found that Id1 was upregulated during the cardiac differentiation of P19CL6 cells. The expression of cardiac specific marker genes, Gata4, {alpha}-MHC and ISL1, was upregulated in P19CL6 cells stably transfected with Id1 (P19CL6-Id1) during cardiac differentiation. The overexpression of Id1 reduced the number of cells in G1 phase and increased the cell population in G2, M and S phases, while knockdown of Id1 increased the number of cells in G1 phase from 48.6 {+-} 2.51% to 62.2 {+-} 1.52% at day 0 of cardiac induction, and from 52.5 {+-} 3.41% to 63.7 {+-} 1.02% at day 3 after cardiac induction, indicating that Id1 promoted proliferation of P19CL6 cells. Luciferase assays showed that the activity of TOP flash was higher in P19CL6-Id1 cells than wildtype P19CL6 cells, while Id1 expression was also upregulated in P19CL6 cells treated with Wnt3a or LiCl. This indicates that there may be positive feedback between Id1 and Wnt signaling which plays an important role in cardiac differentiation.

  15. PCB153-Induced Overexpression of ID3 Contributes to the Development of Microvascular Lesions

    PubMed Central

    Das, Jayanta K.; Felty, Quentin

    2014-01-01

    Microvascular lesions resulting from endothelial cell dysfunction are produced in the brain, lung, kidney, and retina of patients of complex chronic diseases. The environmental and molecular risk factors which may contribute in the development of microvascular damage are unclear. The mechanism(s) responsible for initiating microvascular damage remain poorly defined, although several inciting factors have been proposed, including environmental toxicants-induced oxidative stress. Enhanced neovascularization has been implicated in either the development or progression of proliferative vascular lesions. Here, we present evidence for how PCB-induced ROS may contribute to the development of a neovascular phenotype with the aim of elucidating the role of environmental toxicants in endothelial dysfunction with a specific focus on the inhibitor of differentiation protein ID3. We used a combination of phenotype and immunohistochemical analysis followed by validating with protein expression and post-translational modifications with Western Blot and MALDI-TOF/TOF analysis. We also looked for a correlation between ID3 expression in vascular tissue. Our results showed that PCB-induced ROS mediated a highly tube branched neovascular phenotype that also depended on ID3 and Pyk2; and PCB153 treatment increased the size of endothelial spheroids under conditions typically used for clonal selection of stem cell spheroids. High ID3 protein expression correlated with a greater degree of malignancy and oxidative DNA damage marker 8-OHdG in blood vessels from human subjects. PCB153 treatment increased both serine and tyrosine phosphorylation of endothelial ID3. Stable ID3 overexpression increased cell survival of human microvascular endothelial cell line hCMEC/D3. In summary, our data provide evidence that ID3 may play a critical role in regulating vascular endothelial cell survival and development of microvascular lesions induced by persistent environmental pollutants such as PCB153. Findings of this study are important because they provide a new paradigm by which PCBs may contribute to the growth of microvascular lesions. PMID:25090023

  16. Id-1 promotes osteosarcoma cell growth and inhibits cell apoptosis via PI3K/AKT signaling pathway.

    PubMed

    Hao, Liang; Liao, Qi; Tang, Qiang; Deng, Huan; Chen, Lu

    2016-02-12

    Accumulating evidence reveals that Id-1 is upregulated and functions as a potential tumor promoter in several human cancer types. However, the role of Id-1 in osteosarcoma (OS) is unknown. In present study, we found that Id-1 expression was elevated in OS tissues than adjacent normal bone tissues. More importantly, we demonstrated that overexpression of Id-1 is significantly correlated with tumor progression and poor survival in OS patients. Furthermore, increased expression of Id-1 was observed in OS cell lines and ectopic expression of Id-1 significantly enhanced invitro cell proliferation and promoted invivo tumor growth, whereas knockdown of Id-1 suppressed OS cells growth. Moreover, our experimental data revealed that Id-1 promotes cell proliferation by facilitating cell cycle progression and inhibits cell apoptosis. Mechanistically, the effects of Id-1 in OS cells is at least partly through activation of PI3K/Akt signaling pathway. Therefore, we identified a tumorigenic role of Id-1 in OS and suggested a potential therapeutic target for OS patients. PMID:26797271

  17. Attitudes of Israeli Teachers and Paraprofessionals towards the New Definition of ID and Their Willingness to Cope with Special Education Law Changes

    ERIC Educational Resources Information Center

    Lifshitz, Hefziba; Nissim, Shoshanna; Cohen, Sara

    2008-01-01

    Attitudes of teachers (N = 96) and paraprofessionals (N = 48) working with students with intellectual disability (ID) towards the new definition of ID (Luckasson et al., 1992, 2002), was examined. The main innovation of the new definition of ID is the cancellation of the four ID levels, suggesting an optimistic view, especially towards individuals

  18. Population substructure in Cache County, Utah: the Cache County study

    PubMed Central

    2014-01-01

    Background Population stratification is a key concern for genetic association analyses. In addition, extreme homogeneity of ethnic origins of a population can make it difficult to interpret how genetic associations in that population may translate into other populations. Here we have evaluated the genetic substructure of samples from the Cache County study relative to the HapMap Reference populations and data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Results Our findings show that the Cache County study is similar in ethnic diversity to the self-reported "Whites" in the ADNI sample and less homogenous than the HapMap CEU population. Conclusions We conclude that the Cache County study is genetically representative of the general European American population in the USA and is an appropriate population for conducting broadly applicable genetic studies. PMID:25078123

  19. Differential gene expression of FoxO1, ID1, and ID3 between young and older men and associations with muscle mass and function

    PubMed Central

    Buford, Thomas W.; Cooke, Matthew B.; Shelmadine, Brian D.; Hudson, Geoffrey M.; Redd, Liz L.; Willoughby, Darryn S.

    2013-01-01

    Background and aims Aging is associated with significant losses of skeletal muscle mass and function. Numerous biochemical molecules have been implicated in the development of these age-related changes, however evidence from human models is sparse. Assessment of transcript expression is useful as it requires minimal tissue and may potentially be used in clinical trials. This study aimed to compare mRNA expression of proteolytic genes in skeletal muscle of young (18–35 yrs) and older (55–75 yrs) men. Methods Muscle tissue was obtained from young (n=14, 21.35±1.03 yrs) and older (n=13, 63.85±1.83 yrs) men using percutaneous biopsy, and transcript expression was quantified using real-time polymerase chain reaction. Lower limb muscle mass was assessed using DEXA while concentric peak torque (PT) and power were assessed via isokinetic dynamometer. When age-related differences in mRNA expression were observed, Pearson correlation coefficients were obtained to examine the relationship of transcripts to muscle mass and function. Results Older muscle contained significantly more transcript for Forkhead Box O 1 (FoxO1, p=0.001), Inhibitor of DNA binding 1 (ID1, p=0.009), and Inhibitor of DNA Binding 3 (ID3, p=0.043) than young muscle. FoxO1 was significantly correlated with lean mass (R=−0.44, p=0.023) and PT (R=−0.40, p=0.046) while ID3 was significantly correlated with PT (R=−0.58, p=0.001) and power (R=−0.65, p<0.001). Moreover, ID1 was significantly correlated with all assessed measures of muscle function - mass (R=−0.39, p=0.046), PT (R=−0.53, p=0.005), and power (R=−0.520, p=0.005). Conclusion These data suggest that FoxO1, ID1, and ID3 are potentially useful as clinical biomarkers of age-related muscle atrophy and dysfunction. PMID:21993163

  20. Geothermal development plan: Yuma County

    SciTech Connect

    White, D.H.; Goldstone, L.A.

    1982-08-01

    The Yuma County Area Development Plan evaluated the county-wide market potential for utilizing geothermal energy. The study identified four potential geothermal resource areas with temperatures less than 90/sup 0/C (194/sup 0/F), and in addition, two areas are inferred to contain geothermal resources with intermediate (90/sup 0/C to 150/sup 0/C, 194/sup 0/F to 300/sup 0/F) temperature potential. The resource areas are isolated, although one resource area is located near Yuma, Arizona. One resource site is inferred to contain a hot dry rock resource. Anticipated population growth in the county is expected to be 2 percent per year over the next 40 years. The primary employment sector is agriculture, though some light industry is located in the county. Water supplies are found to be adequate to support future growth without advese affect on agriculture. Six firms were found in Yuma County which may be able to utilize geothermal energy for process heat needs. In addition, several agricultural processors were found, concentrated in citrus processing and livestock raising. Geothermal energy utilization projections suggest that by the year 2000, geothermal energy may economically provide the energy equivalent of 53,000 barrels of oil per year to the industrial sector if developed privately. Geothermal utilization projections increase to 132,000 barrels of oil per year by 2000 if a municipal utility developed the resource.

  1. A Comprehensive Analysis of Primer IDs to Study Heterogeneous HIV-1 Populations.

    PubMed

    Seifert, David; Di Giallonardo, Francesca; Töpfer, Armin; Singer, Jochen; Schmutz, Stefan; Günthard, Huldrych F; Beerenwinkel, Niko; Metzner, Karin J

    2016-01-16

    Determining the composition of viral populations is becoming increasingly important in the field of medical virology. While recently developed computational tools for viral haplotype analysis allow for correcting sequencing errors, they do not always allow for the removal of errors occurring in the upstream experimental protocol, such as PCR errors. Primer IDs (pIDs) are one method to address this problem by harnessing redundant template resampling for error correction. By using a reference mixture of five HIV-1 strains, we show how pIDs can be useful for estimating key experimental parameters, such as the substitution rate of the PCR process and the reverse transcription (RT) error rate. In addition, we introduce a hidden Markov model for determining the recombination rate of the RT PCR process. We found no strong sequence-specific bias in pID abundances (the same RT efficiencies as compared to commonly used short, specific RT primers) and no effects of pIDs on the estimated distribution of the references viruses. PMID:26711506

  2. Identification of Tox chromatin binding properties and downstream targets by DamID-Seq.

    PubMed

    de Jesus Domingues, António Miguel; Artegiani, Benedetta; Dahl, Andreas; Calegari, Federico

    2016-03-01

    In recent years, DNA adenine methyltransferase identification (DamID) has emerged as a powerful tool to profile protein-DNA interaction on a genome-wide scale. While DamID has been primarily combined with microarray analyses, which limits the spatial resolution and full potential of this technique, our group was the first to combine DamID with sequencing (DamID-Seq) for characterizing the binding loci and properties of a transcription factor (Tox) (sequencing data available at NCBI's Gene Expression Omnibus under the accession number GSE64240). Our approach was based on the combination and optimization of several bioinformatics tools that are here described in detail. Analysis of Tox proximity to transcriptional start sites, profiling on enhancers and binding motif has allowed us to identify this transcription factor as an important new regulator of neural stem cells differentiation and newborn neurons maturation during mouse cortical development. Here we provide a valuable resource to study the role of Tox as a novel key determinant of mammalian somatic stem cells during development of the nervous and lymphatic system, in which this factor is known to be active, and describe a useful pipeline to perform DamID-Seq analyses for any other transcription factor. PMID:26981424

  3. SmartID: a highly accurate physics-based isotope attribution algorithm

    NASA Astrophysics Data System (ADS)

    Harrison, M. J.; Sjoden, G. E.; Detwiler, R.

    2010-04-01

    The spectral post-processing algorithm Advanced Synthetically Enhanced Detector Resolution Algorithm (ASEDRA (patent pending)) has shown to be a powerful tool for deconvolving full energy peaks from scintillation spectrometeracquired gamma-ray spectra, effectively improving obtainable data-synthesized energy resolutions by a factor of four to six times over what is rendered from the detector. An isotope attribution algorithm, SmartID, was developed to augment ASEDRA in order to improve radionuclide identification accuracy. SmartID utilizes a novel, physics-based method of importance weighting the ASEDRA-identified peaks and the emissions of a candidate isotope. This methodology enhances the screening of potential false peaks and prevents isotope mismatches. As a final step, SmartID assigns a physical matching attribution score to each possible isotope match to reflect goodness-of-fit. A test suite of 105 gammaray spectra acquired with a 2"2" NaI:Tl spectrometer under varying shielding conditions and various single and multisource configurations were recorded for testing the accuracy of ASEDRA+SmartID. The sources utilized in the tests included 133Ba, 109Cd, 57Co, 60Co, 137Cs, 152Eu, 54Mn, 22Na, 232Th, natural uranium rods and a PuBe source. Shielding configurations varied widely, ranging from none to more than 2.5cm Pb. Overall, SmartID proved to be more than 95% accurate in attributing the correct isotope(s) to the spectra.

  4. Methods of "fake ID" obtainment and use in underage college students.

    PubMed

    Martinez, Julia A; Sher, Kenneth J

    2010-07-01

    Fake IDs are highly prevalent among underage college students, and are strongly associated with heavy drinking. However it is not currently known how exactly fake IDs are most commonly obtained and used, and how often individuals are caught. Such information could aid law enforcement and school personnel in their enforcement responsibilities, and might further elucidate the extent and means by which students "make ethical compromises" to gain illegal access to alcohol. A cross-sectional online survey of 1098 underage students at a large Midwestern university indicated that comparable to previous findings, 21.0% reported possessing a fake ID (which was strongly associated with past-month frequent heavy drinking; OR=4.84, 95% CI=3.41-6.86). Of those with fake IDs, 93.5% reported having used them, and 29.1% reported having been caught. Greek (i.e., fraternity/sorority) members were more likely than others to obtain them through a Greek organization (OR=8.02, 95% CI=1.81-35.54). Also, men were more likely than women to buy (OR=2.74, 95% CI=1.57-4.77), yet less likely to be given them (OR=0.53, 95% CI=0.31-0.90). Future studies might examine whether and how fake ID capture reduces (or exacerbates) drinking over time. PMID:20359829

  5. Identification of Tox chromatin binding properties and downstream targets by DamID-Seq

    PubMed Central

    de Jesus Domingues, António Miguel; Artegiani, Benedetta; Dahl, Andreas; Calegari, Federico

    2016-01-01

    In recent years, DNA adenine methyltransferase identification (DamID) has emerged as a powerful tool to profile protein-DNA interaction on a genome-wide scale. While DamID has been primarily combined with microarray analyses, which limits the spatial resolution and full potential of this technique, our group was the first to combine DamID with sequencing (DamID-Seq) for characterizing the binding loci and properties of a transcription factor (Tox) (sequencing data available at NCBI's Gene Expression Omnibus under the accession number GSE64240). Our approach was based on the combination and optimization of several bioinformatics tools that are here described in detail. Analysis of Tox proximity to transcriptional start sites, profiling on enhancers and binding motif has allowed us to identify this transcription factor as an important new regulator of neural stem cells differentiation and newborn neurons maturation during mouse cortical development. Here we provide a valuable resource to study the role of Tox as a novel key determinant of mammalian somatic stem cells during development of the nervous and lymphatic system, in which this factor is known to be active, and describe a useful pipeline to perform DamID-Seq analyses for any other transcription factor. PMID:26981424

  6. The helix-loop-helix protein id1 controls stem cell proliferation during regenerative neurogenesis in the adult zebrafish telencephalon.

    PubMed

    Rodriguez Viales, Rebecca; Diotel, Nicolas; Ferg, Marco; Armant, Olivier; Eich, Julia; Alunni, Alessandro; Mrz, Martin; Bally-Cuif, Laure; Rastegar, Sepand; Strhle, Uwe

    2015-03-01

    The teleost brain has the remarkable ability to generate new neurons and to repair injuries during adult life stages. Maintaining life-long neurogenesis requires careful management of neural stem cell pools. In a genome-wide expression screen for transcription regulators, the id1 gene, encoding a negative regulator of E-proteins, was found to be upregulated in response to injury. id1 expression was mapped to quiescent type I neural stem cells in the adult telencephalic stem cell niche. Gain and loss of id1 function in vivo demonstrated that Id1 promotes stem cell quiescence. The increased id1 expression observed in neural stem cells in response to injury appeared independent of inflammatory signals, suggesting multiple antagonistic pathways in the regulation of reactive neurogenesis. Together, we propose that Id1 acts to maintain the neural stem cell pool by counteracting neurogenesis-promoting signals. PMID:25376791

  7. Archuleta County CO Lineaments

    SciTech Connect

    Zehner, Richard E.

    2012-01-01

    Citation Information: Originator: Earth Science &Observation Center (ESOC), CIRES, University of Colorado at Boulder Originator: Geothermal Development Associates, Reno, Nevada Publication Date: 2012 Title: Archuleta Lineaments Edition: First Publication Information: Publication Place: Reno Nevada Publisher: Geothermal Development Associates, Reno, Nevada Description: This layer traces apparent topographic and air-photo lineaments in the area around Pagosa springs in Archuleta County, Colorado. It was made in order to identify possible fault and fracture systems that might be conduits for geothermal fluids. Geothermal fluids commonly utilize fault and fractures in competent rocks as conduits for fluid flow. Geothermal exploration involves finding areas of high near-surface temperature gradients, along with a suitable “plumbing system” that can provide the necessary permeability. Geothermal power plants can sometimes be built where temperature and flow rates are high. To do this, georeferenced topographic maps and aerial photographs were utilized in an existing GIS, using ESRI ArcMap 10.0 software. The USA_Topo_Maps and World_Imagery map layers were chosen from the GIS Server at server.arcgisonline.com, using a UTM Zone 13 NAD27 projection. This line shapefile was then constructed over that which appeared to be through-going structural lineaments in both the aerial photographs and topographic layers, taking care to avoid manmade features such as roads, fence lines, and right-of-ways. These lineaments may be displaced somewhat from their actual location, due to such factors as shadow effects with low sun angles in the aerial photographs. Note: This shape file was constructed as an aid to geothermal exploration in preparation for a site visit for field checking. We make no claims as to the existence of the lineaments, their location, orientation, and nature. Spatial Domain: Extent: Top: 4132831.990103 m Left: 311979.997741 m Right: 331678.289280 m Bottom: 4116067.165795 m Contact Information: Contact Organization: Geothermal Development Associates, Reno, Nevada Contact Person: Richard “Rick” Zehner Address: 3740 Barron Way City: Reno State: NV Postal Code: 89511 Country: USA Contact Telephone: 775-737-7806 Spatial Reference Information: Coordinate System: Universal Transverse Mercator (UTM) WGS’1984 Zone 13N False Easting: 500000.00000000 False Northing: 0.00000000 Central Meridian: -105.00000000 Scale Factor: 0.99960000 Latitude of Origin: 0.00000000 Linear Unit: Meter Datum: World Geodetic System 1984 (WGS ’1984) Prime Meridian: Greenwich Angular Unit: Degree Digital Form: Format Name: Shape file

  8. Geothermal development plan: Maricopa county

    SciTech Connect

    White, D.H.

    1981-01-01

    Maricopa county is the area of Arizona receiving top priority since it contains over half of the state's population. The county is located entirely within the Basin and Range physiographic region in which geothermal resources are known to occur. Several approaches were taken to match potential users to geothermal resources. One approach involved matching some of the largest facilities in the county to nearby geothermal resources. Other approaches involved identifying industrial processes whose heat requirements are less than the average assessed geothermal reservoir temperature of 110/sup 0/C (230/sup 0/F). Since many of the industries are located on or near geothermal resources, geothermal energy potentially could be adapted to many industrial processes.

  9. Id3 Controls Cell Death of 2B4+ Virus-Specific CD8+ T Cells in Chronic Viral Infection.

    PubMed

    Menner, Alexandra J; Rauch, Katharina S; Aichele, Peter; Pircher, Hanspeter; Schachtrup, Christian; Schachtrup, Kristina

    2015-09-01

    Sustained Ag persistence in chronic infection results in a deregulated CD8(+) T cell response that is characterized by T cell exhaustion and cell death of Ag-specific CD8(+) T cells. Yet, the underlying transcriptional mechanisms regulating CD8(+) T cell exhaustion and cell death are poorly defined. Using the experimental mouse model of lymphocytic choriomeningitis virus infection, we demonstrate that the transcriptional regulator Id3 controls cell death of virus-specific CD8(+) T cells in chronic infection. By comparing acute and chronic infection, we showed that Id3 (-) virus-specific CD8(+) T cells were less abundant, whereas the absolute numbers of Id3 (+) virus-specific CD8(+) T cells were equal in chronic and acute infection. Phenotypically, Id3 (-) and Id3 (+) cells most prominently differed with regard to expression of the surface receptor 2B4; although Id3 (-) cells were 2B4(+), almost all Id3 (+) cells lacked expression of 2B4. Lineage-tracing experiments showed that cells initially expressing Id3 differentiated into Id3 (-)2B4(+) cells; in turn, these cells were terminally differentiated and highly susceptible to cell death under conditions of persisting Ag. Enforced Id3 expression specifically increased the persistence of 2B4(+) virus-specific CD8(+) T cells by decreasing susceptibility to Fas/Fas ligand-mediated cell death. Thus, our findings reveal that the transcriptional regulator Id3 promotes the survival of virus-specific CD8(+) T cells in chronic infection and suggest that targeting Id3 might be beneficial for preventing cell death of CD8(+) T cells in chronic infection or for promoting cell death of uncontrolled, hyperactive CD8(+) T cells to prevent immunopathology. PMID:26232435

  10. 7 CFR 1280.606 - Farm Service Agency County Committee.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Farm Service Agency County Committee. 1280.606....606 Farm Service Agency County Committee. Farm Service Agency County Committee, also referred to as... Farm Service Agency County Committee....

  11. 7 CFR 1280.606 - Farm Service Agency County Committee.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Farm Service Agency County Committee. 1280.606....606 Farm Service Agency County Committee. Farm Service Agency County Committee, also referred to as... Farm Service Agency County Committee....

  12. 7 CFR 1280.606 - Farm Service Agency County Committee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Farm Service Agency County Committee. 1280.606....606 Farm Service Agency County Committee. Farm Service Agency County Committee, also referred to as... Farm Service Agency County Committee....

  13. 7 CFR 1280.606 - Farm Service Agency County Committee.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Farm Service Agency County Committee. 1280.606....606 Farm Service Agency County Committee. Farm Service Agency County Committee, also referred to as... Farm Service Agency County Committee....

  14. 7 CFR 1280.606 - Farm Service Agency County Committee.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Farm Service Agency County Committee. 1280.606....606 Farm Service Agency County Committee. Farm Service Agency County Committee, also referred to as... Farm Service Agency County Committee....

  15. Tunneling conductance in topological insulator ferromagnet/d+id mixed wave superconductor junctions

    NASA Astrophysics Data System (ADS)

    Li, Hong; Yang, Xinjian; Jia, Cuiping

    2014-05-01

    The tunneling conductance in a topological insulator (TI) ferromagnet/d+id mixed wave superconductor (FM/d+id S) junction is studied based on the Blonder-Tinkham-Klapwijk (BTK) theory. It is demonstrated that the conductance strongly depends on the magnetic gap, the superconducting pair symmetry orientation, and the magnitude of the ratio of ?2/?1. Here ?1(?2) is the absolute pair potential of d(d) component. For a large magnetic gap, the tunneling spectrum is characterized by a dip structure. When ?=0.25?, the conductance dip appears at eV=?2. Thus, the d+id pairing symmetry as well as the magnitude of the gap can be determined from the experiment of scanning tunneling spectroscopy.

  16. Incorporating Temporal Constraints in the Planning Task of a Hybrid Intelligent IDS

    NASA Astrophysics Data System (ADS)

    Herrero, lvaro; Navarro, Mart; Julin, Vicente; Corchado, Emilio

    Accurate and swift responses are crucial to Intrusion Detection Systems (IDSs), especially if automatic abortion mechanisms are running. In keeping with this idea, this work presents an extension of a Hybrid Intelligent IDS characterized by incorporating temporal control to facilitate real-time processing. The hybrid intelligent -IDS has been conceived as a Hybrid Artificial Intelligent System to perform Intrusion Detection in dynamic computer networks. It combines Artificial Neural Networks and Case-based Reasoning within a multiagent system, in order to develop a more efficient computer network security architecture. Although this temporal issue was taken into account in the initial formulation of this hybrid IDS, in this upgraded version, temporal restrictions are imposed in order to perform real/execution time processing. Experimental results are presented which validate the performance of this upgraded version.

  17. E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease.

    PubMed

    Wang, Lan-Hsin; Baker, Nicholas E

    2015-11-01

    The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous partners, the E proteins. A widely expressed class of inhibitory heterodimer partners-the Inhibitor of DNA-binding (ID) proteins-also exists. Genetic and molecular analyses in humans and in knockout mice implicate E proteins and ID proteins in a wide variety of diseases, belying the notion that they are non-specific partner proteins. Here, we explore relationships of E proteins and ID proteins to a variety of disease processes and highlight gaps in knowledge of disease mechanisms. PMID:26555048

  18. Differential expression of id genes and their potential regulator znf238 in zebrafish adult neural progenitor cells and neurons suggests distinct functions in adult neurogenesis.

    PubMed

    Diotel, Nicolas; Beil, Tanja; Strhle, Uwe; Rastegar, Sepand

    2015-01-01

    Teleost fish display a remarkable ability to generate new neurons and to repair brain lesions during adulthood. They are, therefore, a very popular model to investigate the molecular mechanisms of constitutive and induced neurogenesis in adult vertebrates. In this study, we investigated the expression patterns of inhibitor of DNA binding (id) genes and of their potential transcriptional repressor, znf238, in the whole brain of adult zebrafish. We show that while id1 is exclusively expressed in ventricular cells in the whole brain, id2a, id3 and id4 genes are expressed in broader areas. Interestingly, znf238 was also detected in these regions, its expression overlapping with id2a, id3 and id4 expression. Further detailed characterization of the id-expressing cells demonstrated that (a) id1 is expressed in type 1 and type 2 neural progenitors as previously published, (b) id2a in type 1, 2 and 3 neural progenitors, (c) id3 in type 3 neural progenitors and (d) id4 in postmitotic neurons. Our data provide a detailed map of id and znf238 expression in the brain of adult zebrafish, supplying a framework for studies of id genes function during adult neurogenesis and brain regeneration in the zebrafish. PMID:26107416

  19. The Ubiquitin Ligase ASB4 Promotes Trophoblast Differentiation through the Degradation of ID2

    PubMed Central

    Townley-Tilson, W. H. Davin; Wu, Yaxu; Ferguson, James E.; Patterson, Cam

    2014-01-01

    Vascularization of the placenta is a critical developmental process that ensures fetal viability. Although the vascular health of the placenta affects both maternal and fetal well being, relatively little is known about the early stages of placental vascular development. The ubiquitin ligase Ankyrin repeat, SOCS box-containing 4 (ASB4) promotes embryonic stem cell differentiation to vascular lineages and is highly expressed early in placental development. The transcriptional regulator Inhibitor of DNA binding 2 (ID2) negatively regulates vascular differentiation during development and is a target of many ubiquitin ligases. Due to their overlapping spatiotemporal expression pattern in the placenta and contrasting effects on vascular differentiation, we investigated whether ASB4 regulates ID2 through its ligase activity in the placenta and whether this activity mediates vascular differentiation. In mouse placentas, ASB4 expression is restricted to a subset of cells that express both stem cell and endothelial markers. Placentas that lack Asb4 display immature vascular patterning and retain expression of placental progenitor markers, including ID2 expression. Using JAR placental cells, we determined that ASB4 ubiquitinates and represses ID2 expression in a proteasome-dependent fashion. Expression of ASB4 in JAR cells and primary isolated trophoblast stem cells promotes the expression of differentiation markers. In functional endothelial co-culture assays, JAR cells ectopically expressing ASB4 increased endothelial cell turnover and stabilized endothelial tube formation, both of which are hallmarks of vascular differentiation within the placenta. Co-transfection of a degradation-resistant Id2 mutant with Asb4 inhibits both differentiation and functional responses. Lastly, deletion of Asb4 in mice induces a pathology that phenocopies human pre-eclampsia, including hypertension and proteinuria in late-stage pregnant females. These results indicate that ASB4 mediates vascular differentiation in the placenta via its degradation of ID2. PMID:24586788

  20. Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation.

    PubMed

    Fan, Lucy X; Li, Xinjian; Magenheimer, Brenda; Calvet, James P; Li, Xiaogang

    2012-01-01

    The pan-histone deacetylase (HDAC) inhibitor, trichostatin A, was found to reduce cyst progression and slow the decline of kidney function in Pkd2 knockout mice, model of autosomal dominant polycystic kidney disease (ADPKD). Here we determine whether HDAC inhibition acts by regulating cell proliferation to prevent cyst formation, or by other mechanisms. The loss of Pkd1 caused an upregulation of the inhibitor of differentiation 2 (Id2), a transcription regulator, triggering an Id2-mediated downregulation of p21 in mutant mouse embryonic kidney cells in vitro. Using mouse embryonic kidney cells, mutant for Pkd1, we found that trichostatin A decreased Id2, which resulted in upregulation of p21. Further, phosphorylated retinoblastoma (Rb), usually regulated by Cdk2/Cdk4 activity, was also reduced in these cells. Since these latter enzymes are under the control of p21, these studies suggest that the proliferation of cyst epithelial cells that is reduced by trichostatin A might result from p21 upregulation, or alternatively through the Rb-E2F pathway. Additional studies showed that Id2 directly bound to Rb, releasing the transcription activator E2F from transcriptionally inactive Rb-E2F complexes. HDAC inhibition was able to reverse this process by downregulation of Id2. Furthermore, treatment of pregnant Pkd1 mice with trichostatin A prevented cyst formation in the developing embryonic kidneys, showing that this inhibition is effective in vivo during early cyst formation. Thus, HDAC inhibition targets Id2-mediated pathways to downregulate cystic epithelial cell proliferation and hence cystogenesis. PMID:21900881

  1. A Functionally Significant Polymorphism in ID3 Is Associated with Human Coronary Pathology

    PubMed Central

    Manichaikul, Ani; Rich, Stephen S.; Perry, Heather; Yeboah, Joseph; Law, Michelle; Davis, Molly; Parker, Matthew; Ragosta, Michael; Connelly, Jessica J.

    2014-01-01

    Aims We previously identified association between the ID3 SNP rs11574 and carotid intima-media thickness in the Diabetes Heart Study, a predominantly White diabetic population. The nonsynonymous SNP rs11574 results in an amino acid substitution in the C-terminal region of ID3, attenuating the dominant negative function of ID3 as an inhibitor of basic HLH factor E12-mediated transcription. In the current investigation, we characterize the association between the functionally significant polymorphism in ID3, rs11574, with human coronary pathology. Methods and Results The Multi-Ethnic Study of Atherosclerosis (MESA) is a longitudinal study of subclinical cardiovascular disease, including non-Hispanic White (n?=?2,588), African American (n?=?2,560) and Hispanic (n?=?2,130) participants with data on coronary artery calcium (CAC). The Coronary Assessment in Virginia cohort (CAVA) included 71 patients aged 3080 years, undergoing a medically necessary cardiac catheterization and intravascular ultrasound (IVUS) at the University of Virginia. ID3 SNP rs11574 risk allele was associated with the presence of CAC in MESA Whites (P?=?0.017). In addition, the risk allele was associated with greater atheroma burden and stenosis in the CAVA cohort (P?=?0.003, P?=?0.04 respectively). The risk allele remained predictive of atheroma burden in multivariate analysis (Model 1: covariates age, gender, and LDL, regression coefficient?=?9.578, SE?=?3.657, p?=?0.0110; Model 2: covariates Model 1, presence of hypertension, presence of diabetes, regression coefficient?=?8.389, SE?=?4.788, p?=?0.0163). Conclusions We present additional cohorts that demonstrate association of ID3 SNP rs11574 directly with human coronary artery pathology as measured by CAC and IVUS: one a multiethnic, relatively healthy population with low levels of diabetes and the second a predominantly White population with a higher incidence of T2DM referred for cardiac catheterization. PMID:24603695

  2. ID-1 mass storage system for mainframe by using FDDI network

    SciTech Connect

    Morita, Y.; Fujii, H.; Inoue, E.; Kodama, H. Manabe, A.; Miyamoto, A.; Nomachi, M.; Watase, Y.; Yasu, Y.

    1994-12-31

    The authors have developed an ID-1 mass storage system as a distributed data server for Fujitsu mainframe computers. The system consists of a SONY ID-1 recorder DIR-1000, a tape robot system DMS-24 and a SCSI-II interface DFC-1500, which are connected to Spar Station 10 with an FDDI interface. The maximum speed of 7.5 Mbytes/sec is achieved for data transfer between Sparc Station 10 memory and DIR-1000 with a buffer size of 1 Mbytes. The system has been used successfully since last October to migrate more than 1 Tbytes data.

  3. Trouble Brewing in Orange County. Policy Brief

    ERIC Educational Resources Information Center

    Buck, Stuart

    2010-01-01

    Orange County will soon face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that Orange County faces a total $41.2 billion liability for retiree benefits that are underfunded--including $9.4 billion for the county pension system and an estimated…

  4. Once Distressed, Jackson County Moves On.

    ERIC Educational Resources Information Center

    Baldwin, Fred D.

    1998-01-01

    In 1981, Jackson County, North Carolina, appeared on the first list of "distressed counties" in Appalachia. Since then, the rural county has made significant improvements by investing in its physical infrastructure (which also promotes tourism); fostering economic-development partnerships among governments, small businesses, and local colleges;

  5. Once Distressed, Jackson County Moves On.

    ERIC Educational Resources Information Center

    Baldwin, Fred D.

    1998-01-01

    In 1981, Jackson County, North Carolina, appeared on the first list of "distressed counties" in Appalachia. Since then, the rural county has made significant improvements by investing in its physical infrastructure (which also promotes tourism); fostering economic-development partnerships among governments, small businesses, and local colleges;…

  6. Tennessee Higher Education County Profiles, 2009

    ERIC Educational Resources Information Center

    Tennessee Higher Education Commission, 2009

    2009-01-01

    This report presents a localized perspective on Tennessee higher education for the year 2009, including: (1) county demographic and economic data; (2) information on public and private colleges and universities located in the county; and (4) number of county residents participating in the state's primary need-based and merit-based financial aid…

  7. Community Types and Mortality in Georgia Counties

    ERIC Educational Resources Information Center

    Young, Frank W.

    2012-01-01

    Using an "ecological regional analysis" methodology for defining types of communities and their associated mortality rates, this study of Georgia's 159 counties finds that the suburban and town centered counties have low mortality while the city-centered type predicts low mortality for the whites. The military-centered counties do not predict. The…

  8. Community Types and Mortality in Georgia Counties

    ERIC Educational Resources Information Center

    Young, Frank W.

    2012-01-01

    Using an "ecological regional analysis" methodology for defining types of communities and their associated mortality rates, this study of Georgia's 159 counties finds that the suburban and town centered counties have low mortality while the city-centered type predicts low mortality for the whites. The military-centered counties do not predict. The

  9. 76 FR 13172 - Placer County Water Agency

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... Energy Regulatory Commission Placer County Water Agency Notice of Application Tendered for Filing with... Filed: February 23, 2011 d. Applicant: Placer County Water Agency e. Name of Project: Middle Fork... Manager, Placer County Water Agency, 144 Ferguson Road, Auburn, CA 95603; Telephone: (530) 823-4490....

  10. Kinship Care in Walton County.

    ERIC Educational Resources Information Center

    Charon, Sara L.; Nackerud, Larry

    1996-01-01

    The quality of life of maltreated children placed with relatives was examined through interviews with nine families in Walton County (Georgia) who had taken in related children. Over half of the children had experienced some improvement in home life, school performance, and their physical and mental status. Kinship care families indicated needs…

  11. Community Analysis, Stafford County, Virginia.

    ERIC Educational Resources Information Center

    Central Rappahannock Regional Library, Fredericksburg, VA.

    This study of the present and future library needs of residents of Stafford County, Virginia, with emphasis on the North Stafford areas, includes a review of demographic statistics and recommendations for library services. The currently increasing population is highly dependent on the automobile for transportation, and recommendations for library

  12. Composting in Prince William County

    SciTech Connect

    Lyons, K.

    1995-10-01

    Hidden in a small industrial corner of Prince Williams County, in Northern Virginia, a composting facility, after its first flourishing year in business, has found itself part of a symbiotic triangle. Along with a landfill and a waste-to-energy (WTE) plant, the composting facility is one of three programs that make up a joint public-private venture and form a interjurisdictional solid waste/refuse exchange agreement. Faced with the prospects of having to close a landfill at the end of the year, a mandate on yard waste collection that was increasing collection tonnage, and no room for further landfill development, Fairfax County, with approximately 900,000 residents, needed help. In a turn-around situation, Prince William County--with approximately 240,000 residents, a low budget, and much space available for development--responded. Together the counties created a solid waste exchange. The basis for the program is a unity between the local governments on some solid waste issues and a composting facility. Composting, specifically yard waste composting, has been among the fastest-growing aspects of waste management. In 1990, the nation was composting 2% of its solid waste. By the end of 1995, according to the US EPA, between 4% and 7% of solid waste will be recovered through composting. The number of yard waste composting facilities operating has increased from 651 in 1988 to more than 3,000 in 1994.

  13. Kinship Care in Walton County.

    ERIC Educational Resources Information Center

    Charon, Sara L.; Nackerud, Larry

    1996-01-01

    The quality of life of maltreated children placed with relatives was examined through interviews with nine families in Walton County (Georgia) who had taken in related children. Over half of the children had experienced some improvement in home life, school performance, and their physical and mental status. Kinship care families indicated needs

  14. Partnership Program, Essex County College.

    ERIC Educational Resources Information Center

    Berry, David A.

    The Partnership Program at Essex County College (ECC), in Newark, New Jersey, was a 3-year, intensive, college-high school faculty development project designed to coordinate curriculum and learning strategies in area feeder high schools with content and instructional methods used in introductory college courses. Weekly workshops were conducted…

  15. Natural Decrease in Texas Counties.

    ERIC Educational Resources Information Center

    Koebernick, Thomas E.; Markides, Kyriakos S.

    In replication of other studies, the natural decrease of Texas population was examined in terms of the effect of migration and fertility. Utilizing Texas and U.S. vital statistics and the 1970 U.S. Census of Population, Texas population trends were analyzed for the 1968-72 period by dividing the 254 Texas counties into: (1) 65 natural decrease

  16. Truancy in Yolo County, California.

    ERIC Educational Resources Information Center

    Sommer, Barbara; Tyburczy, Jason

    The problem of truancy in the elementary and junior high schools of California's Yolo County was investigated during the 1980-81 academic year by means of questionnaires completed by 16 school principals and interviews with 30 people representing schools, school district offices, law enforcement agencies, the Department of Social Services, and the

  17. The Licking County Writing Project.

    ERIC Educational Resources Information Center

    Davis, James E., Ed.; Davis, Hazel K., Ed.

    1982-01-01

    The 24 articles in this special journal resulted from the Licking County (Ohio) Writing Project. The articles provide information about the following: (1) how to motivate students and teachers, (2) prewriting activities, (3) lightening the teacher's grading load, (4) the uses of conferences, (5) sustained silent reading, (6) traditional techniques

  18. Community Analysis, Stafford County, Virginia.

    ERIC Educational Resources Information Center

    Central Rappahannock Regional Library, Fredericksburg, VA.

    This study of the present and future library needs of residents of Stafford County, Virginia, with emphasis on the North Stafford areas, includes a review of demographic statistics and recommendations for library services. The currently increasing population is highly dependent on the automobile for transportation, and recommendations for library…

  19. Hydrogeology of Webb County, Texas

    USGS Publications Warehouse

    Lambert, Rebecca B.

    2004-01-01

    Introduction: Webb County, in semiarid South Texas on the U.S.-Mexico border, is a region confronted by increasing stresses on natural resources. Laredo (fig. 1), the largest city in Webb County (population 193,000 in 2000), was one of the 10 fastest-growing metropolitan areas in the country during 1990-2000 (Perry and Mackun, 2001). Commercial and industrial activities have expanded throughout the region to support the maquiladora industry (manufacturing plants in Mexico) along the border and other growth as a result of the passage of the North American Free Trade Agreement. The Rio Grande currently (2002) is the primary source of public water supply for Laredo and other cities along the border in Webb County (fig. 1). Other cities, such as Bruni and Mirando City in the southeastern part of the county, rely on ground-water supplies to meet municipal demands. Increased water demand associated with development and population growth in the region has increased the need for the City of Laredo and Webb County to evaluate alternative water sources to meet future demand. Possible options include (1) supplementing the surface-water supply with ground water, and (2) applying artificial storage and recovery (ASR) technology to recharge local aquifers. These options raise issues regarding the hydraulic capability of the aquifers to store economically substantial quantities of water, current or potential uses of the resource, and possible effects on the quality of water resulting from mixing ground water with alternative source waters. To address some of these issues, the U.S. Geological Survey (USGS), in cooperation with the City of Laredo, began a study in 1996 to assess the ground-water resources of Webb County. A hydrogeologic study was conducted to review and analyze available information on the hydrogeologic units (aquifers and confining units) in Webb County, to locate available wells in the region with water-level and water-quality information from the aquifers, and to analyze the hydraulic properties of the aquifers. The purpose of this report is to document the findings of the study. The information is organized by hydrogeologic unit and presented on this and six other sheets.

  20. EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer

    PubMed Central

    Chinaranagari, Swathi; Sharma, Pankaj; Chaudhary, Jaideep

    2014-01-01

    Inhibitor of DNA binding/differentiation protein 4 (ID4) is dominant negative helix loop helix transcriptional regulator is epigenetically silenced due to promoter hyper-methylation in many cancers including prostate. However, the underlying mechanism involved in epigenetic silencing of ID4 is not known. Here, we demonstrate that ID4 promoter methylation is initiated by EZH2 dependent tri-methylation of histone 3 at lysine 27 (H3K27me3). ID4 expressing (LNCaP) and non-expressing (DU145 and C81) prostate cancer cell lines were used to investigate EZH2, H3K27me3 and DNMT1 enrichment on ID4 promoter by Chromatin immuno-precipitation (ChIP). Enrichment of EZH2, H3K27Me3 and DNMT1 in DU145 and C81 cell lines compared to ID4 expressing LNCaP cell line. Knockdown of EZH2 in DU145 cell line led to re-expression of ID4 and decrease in enrichment of EZH2, H3K27Me3 and DNMT1 demonstrating that ID4 is regulated in an EZH2 dependent manner. ChIP data on prostate cancer tissue specimens and cell lines suggested EZH2 occupancy and H3K27Me3 marks on the ID4 promoter. Collectively, our data indicate a PRC2 dependent mechanism in ID4 promoter silencing in prostate cancer through recruitment of EZH2 and a corresponding increase in H3K27Me3. Increased EZH2 but decreased ID4 expression in prostate cancer strongly supports this model. PMID:25115397

  1. Inhibitor of Differentiation 4 (ID4) Inactivation Promotes De Novo Steroidogenesis and Castration-Resistant Prostate Cancer

    PubMed Central

    Patel, Divya; Knowell, Ashley E.; Korang-Yeboah, Maxwell; Sharma, Pankaj; Joshi, Jugal; Glymph, Shanora; Chinaranagari, Swathi; Nagappan, Peri; Palaniappan, Ravi; Bowen, Nathan J.

    2014-01-01

    Prostate cancer (PCa) is the most commonly diagnosed cancer in men in the Western world. The transition of androgen-dependent PCa to castration-resistant (CRPC) is a major clinical manifestation during disease progression and presents a therapeutic challenge. Our studies have shown that genetic ablation of inhibitor of differentiation 4 (Id4), a dominant-negative helix loop helix protein, in mice results in prostatic intraepithelial neoplasia lesions and decreased Nkx3.1 expression without the loss of androgen receptor (Ar) expression. ID4 is also epigenetically silenced in the majority of PCa. However, the clinical relevance and molecular pathways altered by ID4 inactivation in PCa are not known. This study investigates the effect of loss of ID4 in PCa cell lines on tumorigenicity and addresses the underlying mechanism. Stable silencing of ID4 in LNCaP cells (L-ID4) resulted in increased proliferation, migration, invasion, and anchorage-independent growth. An increase in the rate of tumor growth, weight, and volume was observed in L-ID4 xenografts compared with that in the LNCaP cells transfected with nonspecific short hairpin RNA (L+ns) in noncastrated mice. Interestingly, tumors were also observed in castrated mice, suggesting that loss of ID4 promotes CRPC. RNA sequence analysis revealed a gene signature mimicking that of constitutively active AR in L-ID4, which was consistent with gain of de novo steroidogenesis. Prostate-specific antigen expression as a result of persistent AR activation was observed in L-ID4 cells but not in L+ns cells. The results demonstrate that ID4 acts as a tumor suppressor in PCa, and its loss, frequently observed in PCa, promotes CRPC through constitutive AR activation. PMID:24921661

  2. 76 FR 43196 - Implementation of the Truth in Caller ID Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ... proposed in the Caller ID Act NPRM, 76 FR 16367, the revised rules also specify that blocking or attempting... manipulating caller identification information with the intent to defraud, cause harm, or wrongfully obtain... information with the intent to defraud, cause harm, or wrongfully obtain anything of value. Synopsis of...

  3. Single mimivirus particles intercepted and imaged with an X-ray laser (CXIDB ID 2)

    DOE Data Explorer

    Seibert, M. Marvin; Ekeberg, Tomas

    2011-02-02

    These are the files used to reconstruct the images in the paper "Single Mimivirus particles intercepted and imaged with an X-ray laser". Besides the diffracted intensities, the Hawk configuration files used for the reconstructions are also provided. The files from CXIDB ID 2 are the pattern and configuration files for the pattern showed in Figure 2b in the paper.

  4. 77 FR 55813 - Transition of DOE-ID Public Reading Room

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... Library at 1776 Science Center Drive, Idaho Falls, ID 83401, beginning September 1, 2012. Access to....ntis.gov . DATES: Effective September 1, 2012. ADDRESSES: INL Research Library, 1776 Science Center...: Notice. SUMMARY: Pursuant to 5 U.S.C. 552(a) of the Freedom of Information Act and in accordance...

  5. Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1

    SciTech Connect

    Desprez, P.; Hara, E.; Bissell, M.J.

    1995-06-01

    Cell proliferation and differentiation are precisely coordinated during the development and maturation of the mammary gland, and this balance invariably is disrupted during carcinogenesis. Little is known about the cell-specific transcription factors that regulate these processes in the mammary gland. The mouse mammary epithelial cell line SCp2 grows well under standard culture conditions but arrests growth, forms alveolus-like structures, and expresses {beta}-casein, a differentiation marker, 4 to 5 days after exposure to basement membrane and lactogenic hormones (differentiation signals). The authors show that this differentiation entails a marked decline in the expression of Id-1, a helix-loop-helix (HLH) protein that inactivates basic HLH transcription factors in other cell types. SCp2 cells stably transfected with an Id-1 expression vector grew more rapidly than control cells under standard conditions, but in response to differentiation signals, they lost three-dimensional organization, invaded the basement membrane, and then resumed growth. SCp2 cells expressing an Id-1 antisense vector grew more slowly than controls; in response to differentiation signals, they remained stably growth arrested and fully differentiated, as did control cells. The authors suggest that Id-1 renders cells refractory to differentiation signals and receptive to growth signals by inactivating one or more basic HLH proteins that coordinate growth and differentiation in the mammary epithelium. 53 refs., 6 figs.

  6. 76 FR 9266 - Proposed Amendment of Class D and Class E Airspace; Idaho Falls, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    .... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by reference in 14 CFR...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... Falls, ID AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed...

  7. 75 FR 41773 - Proposed Amendment of Class E Airspace; Arco, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; Arco, ID...

  8. 75 FR 18881 - Notice of Realty Action: Proposed Sale of Public Land in Caribou Co., ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... Bureau of Land Management Notice of Realty Action: Proposed Sale of Public Land in Caribou Co., ID AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action. SUMMARY: The Bureau of Land..., Idaho by direct sale under the provisions of the Federal Land Policy and Management Act of 1976...

  9. Use of false ID cards and other deceptive methods to purchase alcoholic beverages during high school.

    PubMed

    Schwartz, R H; Farrow, J A; Banks, B; Giesel, A E

    1998-01-01

    Altered motor vehicle drivers's licenses or other falsified or counterfeit photo identification cards are widely and illegally used by teenagers to obtain beer and other alcohol beverages. We obtained information on the methods currently used by teenagers to purchase beer and wine by asking nine hundred teenagers, between 16-19 years old to complete a brief, confidential questionnaire. High school students most often obtained alcoholic beverages by requesting someone of legal age to purchase it for them. College students used borrowed, altered, or counterfeit identification (ID) more often than high school students. Photo IDs purchased through mail order from a magazine advertisement were used infrequently and when use was attempted, they were sometimes (25%) unsuccessful. Fifteen percent of high school students, 14% of college freshmen, and 24% of teenage drug abusers were able to purchase beer by the case with borrowed, altered, or fake ID. Suggestions to reduce sales of alcohol-containing beverages to minors include universal "carding" of prospective purchasers, use of two view or hologram photos on a drivers' license, requiring three different ID cards at the point of purchase, and penalties to stores that fail to make a good effort to identify underage customers. PMID:9789157

  10. Phytophthora-ID.org: a sequence-based Phytophthora identification tool

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Contemporary species identification relies strongly on sequence-based identification, yet resources for identification of many fungal and oomycete pathogens are rare. We developed the Phytophthora ID website, which contains two web-based, searchable databases for rapid identification of Phytophthora...

  11. Time-Resolved Research at the Advanced Photon Source Beamline 7-ID

    NASA Astrophysics Data System (ADS)

    Dufresne, Eric M.; Adams, Bernhard; Arms, Dohn A.; Chollet, Matthieu; Landahl, Eric C.; Li, Yuelin; Walko, Donald A.; Wang, Jin

    2010-06-01

    The Sector 7 undulator beamline (7-ID) of the Advanced Photon Source (APS) is dedicated to time-resolved x-ray research and is capable of ultrafast measurements on the order of 100 ps. Beamline 7-ID has a laser laboratory featuring a Ti:Sapphire system (average power of 2.5 W, pulse duration <50 fs, repetition rate 1-5 kHz) that can be synchronized to the bunch pattern of the storage ring. The laser is deliverable to x-ray enclosures, which contain diffractometers, as well as motorized optical tables for table-top experiments. Beamline 7-ID has a single APS Undulator A and uses a diamond (111) double-crystal monochromator, providing good energy resolution over a range of 6-24 keV. Available optics include Kirkpatrick-Baez (KB) mirrors to microfocus the x-ray beam. A variety of time-resolved diffraction and spectroscopy research is available at 7-ID, with experiments being done in the atomic, molecular, optical, chemistry, and solid state (bulk and surface) fields.

  12. OpenID connect as a security service in Cloud-based diagnostic imaging systems

    NASA Astrophysics Data System (ADS)

    Ma, Weina; Sartipi, Kamran; Sharghi, Hassan; Koff, David; Bak, Peter

    2015-03-01

    The evolution of cloud computing is driving the next generation of diagnostic imaging (DI) systems. Cloud-based DI systems are able to deliver better services to patients without constraining to their own physical facilities. However, privacy and security concerns have been consistently regarded as the major obstacle for adoption of cloud computing by healthcare domains. Furthermore, traditional computing models and interfaces employed by DI systems are not ready for accessing diagnostic images through mobile devices. RESTful is an ideal technology for provisioning both mobile services and cloud computing. OpenID Connect, combining OpenID and OAuth together, is an emerging REST-based federated identity solution. It is one of the most perspective open standards to potentially become the de-facto standard for securing cloud computing and mobile applications, which has ever been regarded as "Kerberos of Cloud". We introduce OpenID Connect as an identity and authentication service in cloud-based DI systems and propose enhancements that allow for incorporating this technology within distributed enterprise environment. The objective of this study is to offer solutions for secure radiology image sharing among DI-r (Diagnostic Imaging Repository) and heterogeneous PACS (Picture Archiving and Communication Systems) as well as mobile clients in the cloud ecosystem. Through using OpenID Connect as an open-source identity and authentication service, deploying DI-r and PACS to private or community clouds should obtain equivalent security level to traditional computing model.

  13. Single mimivirus particles intercepted and imaged with an X-ray laser (CXIDB ID 1)

    DOE Data Explorer

    Seibert, M. Marvin; Ekeberg, Tomas; Maia, Filipe R.N.C.

    2011-02-02

    These are the files used to reconstruct the images in the paper "Single Mimivirus particles intercepted and imaged with an X-ray laser". Besides the diffracted intensities, the Hawk configuration files used for the reconstructions are also provided. The files from CXIDB ID 1 are the pattern and configuration files for the pattern showed in Figure 2a in the paper.

  14. Time-Resolved Research at the Advanced Photon Source Beamline 7-ID

    SciTech Connect

    Dufresne, Eric M.; Adams, Bernhard; Arms, Dohn A.; Chollet, Matthieu; Li, Yuelin; Walko, Donald A.; Wang Jin; Landahl, Eric C.

    2010-06-23

    The Sector 7 undulator beamline (7-ID) of the Advanced Photon Source (APS) is dedicated to time-resolved x-ray research and is capable of ultrafast measurements on the order of 100 ps. Beamline 7-ID has a laser laboratory featuring a Ti:Sapphire system (average power of 2.5 W, pulse duration <50 fs, repetition rate 1-5 kHz) that can be synchronized to the bunch pattern of the storage ring. The laser is deliverable to x-ray enclosures, which contain diffractometers, as well as motorized optical tables for table-top experiments. Beamline 7-ID has a single APS Undulator A and uses a diamond (111) double-crystal monochromator, providing good energy resolution over a range of 6-24 keV. Available optics include Kirkpatrick-Baez (KB) mirrors to microfocus the x-ray beam. A variety of time-resolved diffraction and spectroscopy research is available at 7-ID, with experiments being done in the atomic, molecular, optical, chemistry, and solid state (bulk and surface) fields.

  15. Evaluation of optical security features in ID documents, currency, and stamps

    NASA Astrophysics Data System (ADS)

    Mercer, John W.

    2002-04-01

    Optical security features have been increasingly used to protect and ensure the integrity of value documents. The types of optical features and their purposes are discussed. The application of these optical features to ID documents, currency and postage stamps are discussed. Particular attention is paid to the fraud and counterfeit resistance of the features in relation to the specific document.

  16. Time-Resolved Research at the Advanced Photon Source Beamline 7-ID

    SciTech Connect

    Dufresne, Eric M.; Adams, Bernhard; Arms, Dohn A.; Chollet, Matthieu; Landahl, Eric C.; Li, Yuelin; Walko, Donald A.; Wang, Jin

    2010-08-02

    The Sector 7 undulator beamline (7-ID) of the Advanced Photon Source (APS) is dedicated to time-resolved x-ray research and is capable of ultrafast measurements on the order of 100 ps. Beamline 7-ID has a laser laboratory featuring a Ti:Sapphire system (average power of 2.5W, pulse duration <50 fs, repetition rate 1-5 kHz) that can be synchronized to the bunch pattern of the storage ring. The laser is deliverable to x-ray enclosures, which contain diffractometers, as well as motorized optical tables for table-top experiments. Beamline 7-ID has a single APS Undulator A and uses a diamond (111) double-crystal monochromator, providing good energy resolution over a range of 6-24 keV. Available optics include Kirkpatrick-Baez (KB) mirrors to microfocus the x-ray beam. A variety of time-resolved diffraction and spectroscopy research is available at 7-ID, with experiments being done in the atomic, molecular, optical, chemistry, and solid state (bulk and surface) fields.

  17. Identification of Interactions in the NMD Complex Using Proximity-Dependent Biotinylation (BioID)

    PubMed Central

    Schweingruber, Christoph; Soffientini, Paolo; Ruepp, Marc-David; Bachi, Angela; Mühlemann, Oliver

    2016-01-01

    Proximity-dependent trans-biotinylation by the Escherichia coli biotin ligase BirA mutant R118G (BirA*) allows stringent streptavidin affinity purification of proximal proteins. This so-called BioID method provides an alternative to the widely used co-immunoprecipitation (co-IP) to identify protein-protein interactions. Here, we used BioID, on its own and combined with co-IP, to identify proteins involved in nonsense-mediated mRNA decay (NMD), a post-transcriptional mRNA turnover pathway that targets mRNAs that fail to terminate translation properly. In particular, we expressed BirA* fused to the well characterized NMD factors UPF1, UPF2 and SMG5 and detected by liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) the streptavidin-purified biotinylated proteins. While the identified already known interactors confirmed the usefulness of BioID, we also found new potentially important interactors that have escaped previous detection by co-IP, presumably because they associate only weakly and/or very transiently with the NMD machinery. Our results suggest that SMG5 only transiently contacts the UPF1-UPF2-UPF3 complex and that it provides a physical link to the decapping complex. In addition, BioID revealed among others CRKL and EIF4A2 as putative novel transient interactors with NMD factors, but whether or not they have a function in NMD remains to be elucidated. PMID:26934103

  18. Cytoplasmic intron sequence-retaining transcripts (CIRTs) can be dendritically targeted via ID element retrotransposons

    PubMed Central

    Buckley, Peter T.; Lee, Miler T.; Sul, Jai-Yoon; Miyashiro, Kevin Y.; Bell, Thomas J.; Fisher, Stephen A.; Kim, Junhyong; Eberwine, James

    2011-01-01

    RNA precursors give rise to mRNA after splicing of intronic sequences traditionally thought to occur in the nucleus. Here, we show that intron sequences are retained in a number of dendritically-targeted mRNAs, using microarray and Illumina sequencing of isolated dendritic mRNA as well as in situ hybridization. Many of the retained introns contain ID elements, a class of SINE retrotransposon. A portion of these SINEs confers dendritic targeting to exogenous and endogenous transcripts showing the necessity of ID-mediated mechanisms for the targeting of different transcripts to dendrites. ID elements are capable of selectively altering the distribution of endogenous proteins, providing a link between intronic SINEs and protein function. As such, the ID element represents the first common dendritic targeting element to be found across multiple RNAs. Retention of intronic sequence is a more general phenomenon then previously thought and plays a functional role in the biology of the neuron, partly mediated by co-opted repetitive sequences. PMID:21382548

  19. Developing Technical Expertise in Secondary Technical Schools: The Effect of 4C/ID Learning Environments

    ERIC Educational Resources Information Center

    Sarfo, Frederick K.; Elen, Jan

    2007-01-01

    In this study, the effectiveness of learning environments, developed in line with the specifications of the four components instructional design model (4C/ID model) and the additional effect of ICT for fostering the development of technical expertise in traditional Ghanaian classrooms, was assessed. The study had a one-by-one-by-two

  20. Probing mammalian centrosome structure using BioID proximity-dependent biotinylation.

    PubMed

    Firat-Karalar, Elif Nur; Stearns, Tim

    2015-01-01

    Understanding the structure and function of the centrosome will require identification of its constituent components and a detailed characterization of the interactions among these components. Here, we describe the application of proximity-dependent biotin identification (BioID) to identify spatial and temporal relationships among centrosome proteins. The BioID method relies on protein fusions to a promiscuous mutant of the Escherichia coli biotin ligase BirA, which biotinylates proteins that are in a ?10nm labeling radius of the enzyme. The biotinylated proteins are captured by affinity and are identified by mass spectrometry. Proteins identified in this way are referred to as "proximity interactors." Application of BioID to a set of centrosome proteins demonstrated the utility of this approach in overcoming inherent limitations in probing centrosome structure. These studies also demonstrated the potential of BioID for building large-scale proximity interaction maps among centrosome proteins. In this chapter, we describe the work flow for identification of proximity interactions of centrosome proteins, including materials and methods for the generation and characterization of a BirA*-fusion protein expression plasmid, expression of BirA*-fusion proteins in cells, and purification and identification of proximity partners by mass spectrometry. PMID:26175438

  1. 75 FR 47515 - Identification (ID) Cards for Members of the Uniformed Services, Their Dependents, and Other...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    .... It is DoD policy that a distinct DoD ID card shall be issued to uniformed service members, their... for common access card (CAC) life-cycle compliance with Federal Information Processing Standards (FIPS... develop overall policy and establish procedures for providing medical care through the Military...

  2. Infrastructures and Middleware for the Application of eID Cards in eGovernment

    NASA Astrophysics Data System (ADS)

    Walloschke, Thomas

    Cross border eID interoperability is one of the main goals to meet the pan-European challenge. At the same time appropriate conformance to any requirements of flexibility, legal certainty as the case may be guaranteed future will be stipulated.

  3. 77 FR 32921 - Proposed Amendment of Class D and E Airspace; Lewiston, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-04

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class D and E Airspace; Lewiston, ID... Class D and Class E airspace areas. The FAA is proposing this action to enhance the safety and... respective Class D airspace and Class E airspace areas. This action would enhance the safety and...

  4. Support and Self-Efficacy among Latino and White Parents of Children with ID

    ERIC Educational Resources Information Center

    Cohen, Shana R.; Holloway, Susan D.; Dominguez-Pareto, Irenka; Kuppermann, Miriam

    2015-01-01

    Research indicates that mothers of children with ID who receive familial support experience less stress than those who receive less support. Less is known about the relation of support to mothers' evaluation of parenting self-efficacy, particularly in Latino families. We examined the relationship of different types of family support to life…

  5. An alternative method for genotyping of the ACE I/D polymorphism.

    PubMed

    Glenn, Kimberly L; Du, Zhi-Qiang; Eisenmann, Joey C; Rothschild, Max F

    2009-07-01

    The mistyping of the angiotensin I-converting enzyme insertion/deletion (ACE I/D) has been well documented, and new methods have been suggested here to improve the genotyping efficiency. Buccal cell samples were collected from 157 young Caucasians, and genotyped using previously known and newly developed PCR amplification genotyping techniques, as well as PCR-RFLP tests for three single nucleotide polymorphisms (rs4327, rs4341 and rs4343). Inconsistent genotyping results were found when using only the PCR amplification genotyping techniques across repeated attempts (8% to 45%), however, individual SNP genotyping was highly consistent (100%). Two SNPs (rs4341 and rs4343) were in complete LD and SNP rs4327 was in high LD with the ACE I/D. The ACE I/D was in HW equilibrium in the portion of the population with consistent genotyping results, whereas the three SNPs were not in HW equilibrium. The mistyping of ACE I/D by only PCR amplification can be improved using alternative methods. PMID:18622756

  6. The Id, Ego and Super-Ego in "Pride and Prejudice"

    ERIC Educational Resources Information Center

    Liang, Yamin

    2011-01-01

    This paper mainly analyses the the id, ego, and super-ego which exists in the main character Elizabeth from several aspects, such as her pursuit for love, her prejudice towards Mr. Darcy, and the changes in her attitudes towards Wickham. This analysis helps readers appreciate this masterpiece from a different aspect which is related to the…

  7. A Provably Secure Revocable ID-Based Authenticated Group Key Exchange Protocol with Identifying Malicious Participants

    PubMed Central

    Tsai, Tung-Tso

    2014-01-01

    The existence of malicious participants is a major threat for authenticated group key exchange (AGKE) protocols. Typically, there are two detecting ways (passive and active) to resist malicious participants in AGKE protocols. In 2012, the revocable identity- (ID-) based public key system (R-IDPKS) was proposed to solve the revocation problem in the ID-based public key system (IDPKS). Afterwards, based on the R-IDPKS, Wu et al. proposed a revocable ID-based AGKE (RID-AGKE) protocol, which adopted a passive detecting way to resist malicious participants. However, it needs three rounds and cannot identify malicious participants. In this paper, we fuse a noninteractive confirmed computation technique to propose the first two-round RID-AGKE protocol with identifying malicious participants, which is an active detecting way. We demonstrate that our protocol is a provably secure AGKE protocol with forward secrecy and can identify malicious participants. When compared with the recently proposed ID/RID-AGKE protocols, our protocol possesses better performance and more robust security properties. PMID:24991641

  8. 76 FR 55788 - Amendments To Include New Applicant Types on Form ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... regulations.\\5\\ Persons that have previously filed Form ID applications with the Commission are not required... otherwise change any provision of the federal securities laws or the regulations promulgated thereunder. \\4... on EDGAR in another capacity. See Securities Exchange Act Release No. 54865 (December 4, 2006), 71...

  9. 78 FR 61442 - Idaho Disaster #ID-00027 Declaration of Economic Injury

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... ADMINISTRATION Idaho Disaster ID-00027 Declaration of Economic Injury AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Economic Injury Disaster Loan (EIDL) declaration for the... the Administrator's EIDL declaration, applications for economic injury disaster loans may be filed...

  10. 78 FR 45478 - Proposed Establishment of Class E Airspace; Salmon, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation.../Distance Measuring Equipment (VOR/DME) navigation aid, Salmon, ID, to facilitate vectoring of...

  11. Inflammation-induced S100A8 activates Id3 and promotes colorectal tumorigenesis.

    PubMed

    Zhang, Xuemei; Ai, Feiyan; Li, Xiayu; She, Xiaoling; Li, Nan; Tang, Anliu; Qin, Zailong; Ye, Qiurong; Tian, Li; Li, Guiyuan; Shen, Shourong; Ma, Jian

    2015-12-15

    The aberrant expression of S100A8 and S100A9 is linked to nonresolving inflammation and ultimately to carcinogenesis, whereas the underlying mechanism that allows inflammation to progress to specific cancer types remains unknown. Here, we report that S100A8 was induced by inflammation and then promoted colorectal tumorigenesis downstream by activating Id3 (inhibitor of differentiation 3). Using gene expression profiling and immunohistochemistry, we found that both S100A8 and S100A9 were upregulated in the chemically-induced colitis-associated cancer mouse model and in human colorectal cancer specimens. Furthermore, we showed that S100A8 and S100A9 acted as chemoattractant proteins by recruiting macrophages, promoting the proliferation and invasion of colon cancer cell, as well as spurring the cycle that culminates in the acceleration of cancer metastasis in a nude mouse model. S100A8 regulated colon cancer cell cycle and proliferation by inducing Id3 expression while inhibiting p21. Id3 expression was regulated by Smad5, which was directly phosphorylated by Akt1. Our study revealed a novel mechanism in which inflammation-induced S100A8 promoted colorectal tumorigenesis by acting upstream to activate the Akt1-Smad5-Id3 axis. PMID:26135667

  12. Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis

    PubMed Central

    Li, Shasha; Dong, Jiazhen; Wang, Xing; Wang, Yuhan; He, Li; He, Zhiheng; Gao, Yuan; Gao, Shou-Jiang; Lan, Ke

    2014-01-01

    Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), a malignancy commonly found in AIDS patients. Whether KS is a true neoplasm or hyperplasia has been a subject of intensive debate until recently when KSHV is unequivocally shown to efficiently infect, immortalize and transform rat primary mesenchymal precursor cells (MM). Moreover, KSHV-transformed MM cells (KMM) efficiently induce tumors with hallmark features of KS when inoculated into nude mice. Here, we showed Smad1 as a novel binding protein of KSHV latency-associated nuclear antigen (LANA). LANA interacted with and sustained BMP-activated p-Smad1 in the nucleus and enhanced its loading on the Id promoters. As a result, Ids were significantly up-regulated in KMM cells and abundantly expressed in human KS lesions. Strikingly, genetic and chemical inhibition of the BMP-Smad1-Id pathway blocked the oncogenic phenotype of KSHV-transformed cells in vitro and in vivo. These findings illustrate a novel mechanism by which a tumor virus hijacks and converts a developmental pathway into an indispensable oncogenic pathway for tumorigenesis. Importantly, our results demonstrate the efficacy of targeting the BMP-Smad1-Id pathway for inhibiting the growth of KSHV-induced tumors, and therefore identify the BMP pathway as a promising therapeutic target for KS. PMID:25010525

  13. Coupling Molecular Modeling to the Traditional "IR-ID" Exercise in the Introductory Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Stokes-Huby, Heather; Vitale, Dale E.

    2007-01-01

    This exercise integrates the infrared unknown identification ("IR-ID") experiment common to most organic laboratory syllabi with computer molecular modeling. In this modification students are still required to identify unknown compounds from their IR spectra, but must additionally match some of the absorptions with computed frequencies they

  14. 32 CFR 161.7 - ID card life-cycle procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... verify completion of background investigation activities for DoD, military, and civilian CAC populations... authorized for issuance. (2) Initial issuance of a CAC requires, at a minimum, the completion of the Federal... section. (1) Cross-servicing. The uniformed services agree to cross-service the issuance of ID cards...

  15. 77 FR 50417 - Proposed Amendment of Class D and Class E Airspace; Lewiston, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ..., ID (77 FR 32921). Also the geographic coordinates of the airport and navigation aids would be... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963...

  16. National Plant Diagnostic Network, Taxonomic training videos: Introduction to AphID

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Training is a critical part of aphid (Hemiptera: Aphididae) identification. This video provides visual instruction on the use of the expert system, AphID, for aphid examination and identification. The video demonstrates the use of different training modules that allow the user to gain familiarity wi...

  17. Coupling Molecular Modeling to the Traditional "IR-ID" Exercise in the Introductory Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Stokes-Huby, Heather; Vitale, Dale E.

    2007-01-01

    This exercise integrates the infrared unknown identification ("IR-ID") experiment common to most organic laboratory syllabi with computer molecular modeling. In this modification students are still required to identify unknown compounds from their IR spectra, but must additionally match some of the absorptions with computed frequencies they…

  18. Probing mammalian centrosome structure using BioID proximity-dependent biotinylation

    PubMed Central

    Firat-Karalar, Elif Nur; Stearns, Tim

    2016-01-01

    Understanding the structure and function of the centrosome will require identification of its constituent components and a detailed characterization of the interactions among these components. Here, we describe the application of proximity-dependent biotin identification (BioID) to identify spatial and temporal relationships among centrosome proteins. The BioID method relies on protein fusions to a promiscuous mutant of the Escherichia coli biotin ligase BirA, which biotinylates proteins that are in a ~10 nm labeling radius of the enzyme. The biotinylated proteins are captured by affinity and are identified by mass spectrometry. Proteins identified in this way are referred to as “proximity interactors.” Application of BioID to a set of centrosome proteins demonstrated the utility of this approach in overcoming inherent limitations in probing centrosome structure. These studies also demonstrated the potential of BioID for building large-scale proximity interaction maps among centrosome proteins. In this chapter, we describe the work flow for identification of proximity interactions of centrosome proteins, including materials and methods for the generation and characterization of a BirA*-fusion protein expression plasmid, expression of BirA*-fusion proteins in cells, and purification and identification of proximity partners by mass spectrometry. PMID:26175438

  19. 75 FR 22695 - Establishment of Class E Airspace; Bonners Ferry, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... Register a notice of proposed rulemaking to amend controlled airspace at Bonners Ferry, ID (74 FR 58570... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565,...

  20. Functional and molecular features of the Id4+ germline stem cell population in mouse testes

    PubMed Central

    Chan, Frieda; Oatley, Melissa J.; Kaucher, Amy V.; Yang, Qi-En; Bieberich, Charles J.; Shashikant, Cooduvalli S.; Oatley, Jon M.

    2014-01-01

    The maintenance of cycling cell lineages relies on undifferentiated subpopulations consisting of stem and progenitor pools. Features that delineate these cell types are undefined for many lineages, including spermatogenesis, which is supported by an undifferentiated spermatogonial population. Here, we generated a transgenic mouse line in which spermatogonial stem cells are marked by expression of an inhibitor of differentiation 4 (Id4)-green fluorescent protein (Gfp) transgene. We found that Id4-Gfp+ cells exist primarily as a subset of the type Asingle pool, and their frequency is greatest in neonatal development and then decreases in proportion during establishment of the spermatogenic lineage, eventually comprising ?2% of the undifferentiated spermatogonial population in adulthood. RNA sequencing analysis revealed that expression of 11 and 25 genes is unique for the Id4-Gfp+/stem cell and Id4-Gfp?/progenitor fractions, respectively. Collectively, these findings provide the first definitive evidence that stem cells exist as a rare subset of the Asingle pool and reveal transcriptome features distinguishing stem cell and progenitor states within the mammalian male germline. PMID:24939937

  1. 76 FR 8324 - Proposed Amendment of Class E Airspace; McCall, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; McCall, ID...

  2. 75 FR 11936 - Hewlett Packard; Technical Support Call Center; Boise, ID; Notice of Termination of Investigation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Hewlett Packard; Technical Support Call Center; Boise, ID; Notice of... Packard, Technical Support Call Center, Boise, Idaho. The petitioner has requested that the petition...

  3. 76 FR 25537 - Amendment of Class E Airspace; McCall, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... controlled airspace at McCall, ID (76 FR 8324). Interested parties were invited to participate in this... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The...

  4. ACE I/D genotype, adiposity, and blood pressure in children

    PubMed Central

    Eisenmann, Joey C; Sarzynski, Mark A; Glenn, Kim; Rothschild, Max; Heelan, Kate A

    2009-01-01

    Background Angiotensin converting enzyme (ACE) is a possible candidate gene that may influence both body fatness and blood pressure. Although several genetic studies have been conducted in adults, relatively few studies have examined the contribution of potential candidate genes, and specifically ACE I/D, on adiposity and BP phenotypes in childhood. Such studies may prove insightful for the development of the obesity-hypertension phenotype early in life. The purpose of this study was to examine differences in body fatness and resting blood pressure (BP) by ACE I/D genotype, and determine if the association between adiposity and BP varies by ACE I/D genotype in children. Methods 152 children (75 girls, 77 boys) were assessed for body composition (% body fat) using dual energy x-ray absorbtiometry and resting BP according to American Heart Association recommendations. Buccal cell samples were genotyped using newly developed PCR-RFLP tests for two SNPs (rs4341 and rs4343) in complete linkage disequilibrium with the ACE I/D polymorphism. Partial correlations were computed to assess the ociations between % body fat and BP in the total sample and by genotype. ANCOVA was used to examine differences in resting BP by ACE I/D genotype and fatness groups. Results Approximately 39% of youth were overfat based on % body fat (>30% fat in girls, 25% fat in boys). Body mass, body mass index, and fat-free mass were significantly higher in the ACE D-carriers compared to the II group (p < 0.05). BP was not significantly different by ACE I/D genotypes. In the total sample, correlations between adiposity and BP ranged from 0.30 to 0.46, and were not significantly different between genotypes. When grouped by genotype and body fat category, the overfat D-carrier subjects had significantly higher SBP and MAP compared to the normal fat D-carrier and normal fat II groups (p < 0.05). Conclusion ACE D-carriers are heavier than ACE II children; however, BP did not differ by ACE I/D genotype but was adversely influenced in the overfat D-carriers. Further studies are warranted to investigate the genetics of fatness and BP phenotypes in children. PMID:19291311

  5. Initial Validation of the Chinese Quality of Life Questionnaire-Intellectual Disabilities (CQOL-ID): A Cultural Perspective

    ERIC Educational Resources Information Center

    Wong, P. K. S.; Wong, D. F. K.; Schalock, R. L.; Chou, Y-C.

    2011-01-01

    Background: In the field of intellectual disabilities (ID), the quality of life concept has been developing rapidly in Chinese societies including Hong Kong, mainland China and Taiwan. However, there is a lack of locally validated instruments to measure the quality of life of people with ID. The study reported in this paper attempted to validate…

  6. Limited Concordance between Teachers, Parents and Healthcare Professionals on the Presence of Chronic Diseases in ID-Adolescents

    ERIC Educational Resources Information Center

    Oeseburg, B.; Jansen, D. E. M. C.; Reijneveld, S. A.; Dijkstra, G. J.; Groothoff, J. W.

    2010-01-01

    Evidence on teachers' knowledge about somatic and mental chronic diseases among ID-adolescent compared to the knowledge parents and healthcare professionals have, is limited. The aim of this study is: (1) to assess the knowledge of teachers on the presence of chronic diseases in ID-adolescents; (2) to compare teachers with parents and healthcare…

  7. Initial Validation of the Chinese Quality of Life Questionnaire-Intellectual Disabilities (CQOL-ID): A Cultural Perspective

    ERIC Educational Resources Information Center

    Wong, P. K. S.; Wong, D. F. K.; Schalock, R. L.; Chou, Y-C.

    2011-01-01

    Background: In the field of intellectual disabilities (ID), the quality of life concept has been developing rapidly in Chinese societies including Hong Kong, mainland China and Taiwan. However, there is a lack of locally validated instruments to measure the quality of life of people with ID. The study reported in this paper attempted to validate

  8. 6 CFR 37.5 - Validity periods and deadlines for REAL ID driver's licenses and identification cards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Validity periods and deadlines for REAL ID driver's licenses and identification cards. 37.5 Section 37.5 Domestic Security DEPARTMENT OF HOMELAND... Validity periods and deadlines for REAL ID driver's licenses and identification cards. (a)...

  9. 6 CFR 37.5 - Validity periods and deadlines for REAL ID driver's licenses and identification cards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Validity periods and deadlines for REAL ID driver's licenses and identification cards. 37.5 Section 37.5 Domestic Security DEPARTMENT OF HOMELAND... Validity periods and deadlines for REAL ID driver's licenses and identification cards. (a)...

  10. 6 CFR 37.5 - Validity periods and deadlines for REAL ID driver's licenses and identification cards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Validity periods and deadlines for REAL ID driver's licenses and identification cards. 37.5 Section 37.5 Domestic Security DEPARTMENT OF HOMELAND... Validity periods and deadlines for REAL ID driver's licenses and identification cards. (a)...

  11. 6 CFR 37.5 - Validity periods and deadlines for REAL ID driver's licenses and identification cards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Validity periods and deadlines for REAL ID driver's licenses and identification cards. 37.5 Section 37.5 Domestic Security DEPARTMENT OF HOMELAND... Validity periods and deadlines for REAL ID driver's licenses and identification cards. (a)...

  12. 6 CFR 37.5 - Validity periods and deadlines for REAL ID driver's licenses and identification cards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Validity periods and deadlines for REAL ID driver's licenses and identification cards. 37.5 Section 37.5 Domestic Security DEPARTMENT OF HOMELAND... Validity periods and deadlines for REAL ID driver's licenses and identification cards. (a)...

  13. Limited Concordance between Teachers, Parents and Healthcare Professionals on the Presence of Chronic Diseases in ID-Adolescents

    ERIC Educational Resources Information Center

    Oeseburg, B.; Jansen, D. E. M. C.; Reijneveld, S. A.; Dijkstra, G. J.; Groothoff, J. W.

    2010-01-01

    Evidence on teachers' knowledge about somatic and mental chronic diseases among ID-adolescent compared to the knowledge parents and healthcare professionals have, is limited. The aim of this study is: (1) to assess the knowledge of teachers on the presence of chronic diseases in ID-adolescents; (2) to compare teachers with parents and healthcare

  14. Health Professionals' Attitudes and Emotions towards Working with Adults with Intellectual Disability (ID) and Mental Ill Health

    ERIC Educational Resources Information Center

    Rose, N.; Kent, S.; Rose, J.

    2012-01-01

    Objectives: Mainstream mental health services are providing more care for individuals with an intellectual disability (ID); this has implications for staff and service users. Attitudes of staff towards people with ID in mental health services may be negative and negative staff attitudes may have a detrimental impact on service provision. Design: A

  15. Performance of candida ID, a new chromogenic medium for presumptive identification of Candida species, in comparison to CHROMagar Candida.

    PubMed

    Willinger, B; Hillowoth, C; Selitsch, B; Manafi, M

    2001-10-01

    Candida ID agar allows identification of Candida albicans and differentiation of other Candida species. In comparison with CHROMagar Candida, we evaluated the performance of this medium directly from 596 clinical specimens. In particular, detection of C. albicans after 24 h of incubation was easier on Candida ID (sensitivity, 96.8%) than on CHROMagar (sensitivity, 49.6%). PMID:11574621

  16. Performance of Candida ID, a New Chromogenic Medium for Presumptive Identification of Candida Species, in Comparison to CHROMagar Candida

    PubMed Central

    Willinger, Birgit; Hillowoth, Cornelia; Selitsch, Brigitte; Manafi, Mammad

    2001-01-01

    Candida ID agar allows identification of Candida albicans and differentiation of other Candida species. In comparison with CHROMagar Candida, we evaluated the performance of this medium directly from 596 clinical specimens. In particular, detection of C. albicans after 24 h of incubation was easier on Candida ID (sensitivity, 96.8%) than on CHROMagar (sensitivity, 49.6%). PMID:11574621

  17. Id1 expression promotes peripheral CD4{sup +} T cell proliferation and survival upon TCR activation without co-stimulation

    SciTech Connect

    Liu, Chen; Jin, Rong; Wang, Hong-Cheng; Tang, Hui; Liu, Yuan-Feng; Qian, Xiao-Ping; Sun, Xiu-Yuan; Ge, Qing; Sun, Xiao-Hong; Zhang, Yu

    2013-06-21

    Highlights: •Id1 expression enables naïve T cell proliferation without anti-CD28 co-stimulation. •Id1 expression facilitates T cells survival when stimulated with anti-CD3. •Elevation of IL-2 production by Id1 contributes increased proliferation and survival. •Id1 potentiates NF-κB activation by anti-CD3 stimulation. -- Abstract: Although the role of E proteins in the thymocyte development is well documented, much less is known about their function in peripheral T cells. Here we demonstrated that CD4 promoter-driven transgenic expression of Id1, a naturally occurring dominant-negative inhibitor of E proteins, can substitute for the co-stimulatory signal delivered by CD28 to facilitate the proliferation and survival of naïve CD4{sup +} cells upon anti-CD3 stimulation. We next discovered that IL-2 production and NF-κB activity after anti-CD3 stimulation were significantly elevated in Id1-expressing cells, which may be, at least in part, responsible for the augmentation of their proliferation and survival. Taken together, results from this study suggest an important role of E and Id proteins in peripheral T cell activation. The ability of Id proteins to by-pass co-stimulatory signals to enable T cell activation has significant implications in regulating T cell immunity.

  18. Chronic kidney disease in older people with intellectual disability: results of the HA-ID study.

    PubMed

    de Winter, C F; Echteld, M A; Evenhuis, H M

    2014-03-01

    With increasing longevity and cardiovascular events, chronic kidney disease may also become a significant problem in older people with intellectual disability (ID). We studied prevalence and associations of chronic kidney disease as part of the Healthy Ageing and Intellectual Disability (HA-ID) study, a large Dutch cross-sectional study among people with ID aged 50 years and over, using creatinine and cystatin-C measurement in plasma. Glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. Equations based on creatinine (as the MDRD equation) may underestimate kidney dysfunction in people with sarcopenia, because low muscle mass leads to a low creatinine production. Therefore, also prevalence of chronic kidney disease was studied in the sarcopenic group, using different GFR equations. Prevalence of chronic kidney disease, among 635 participants, was 15.3%, which equals prevalence in the general Dutch population. In the group of participants with sarcopenia (n=82), the CKD-EPI equation based on creatinine and cystatin-C gave a higher prevalence of chronic kidney disease than did the MDRD equation, but confidence intervals were very wide. Chronic kidney disease was associated with higher age, Down syndrome, obesity, hypercholesterolemia and hypothyroid disease. GFR should be measured in all older people with ID and polypharmacy, and in older people with ID and Down syndrome as part of the regular health checks. Moreover, if sarcopenia is present and information on GFR is required, this should not be measured based on creatinine only, but additional measures, such as cystatin-C, should be taken into account. PMID:24287320

  19. Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1.

    PubMed Central

    Desprez, P Y; Hara, E; Bissell, M J; Campisi, J

    1995-01-01

    Cell proliferation and differentiation are precisely coordinated during the development and maturation of the mammary gland, and this balance invariably is disrupted during carcinogenesis. Little is known about the cell-specific transcription factors that regulate these processes in the mammary gland. The mouse mammary epithelial cell line SCp2 grows well under standard culture conditions but arrests growth, forms alveolus-like structures, and expresses beta-casein, a differentiation marker, 4 to 5 days after exposure to basement membrane and lactogenic hormones (differentiation signals). We show that this differentiation entails a marked decline in the expression of Id-1, a helix-loop-helix (HLH) protein that inactivates basic HLH transcription factors in other cell types. SCp2 cells stably transfected with an Id-1 expression vector grew more rapidly than control cells under standard conditions, but in response to differentiation signals, they arrested growth and formed three-dimensional structures similar to those of control cells. Id-1-expressing cells did not, however, express beta-casein. Moreover, 8 to 10 days after receiving differentiation signals, they lost three-dimensional organization, invaded the basement membrane, and then resumed growth. SCp2 cells expressing an Id-1 antisense vector grew more slowly than controls; in response to differentiation signals, they remained stably growth arrested and fully differentiated, as did control cells. We suggest that Id-1 renders cells refractory to differentiation signals and receptive to growth signals by inactivating one or more basic HLH proteins that coordinate growth and differentiation in the mammary epithelium. PMID:7760836

  20. 40 CFR 81.274 - Mountain Counties Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Calaveras County, Mariposa County, Nevada Country, Plumas County, Sierra County, Tuolumne County. El Dorado County—all of El Dorado County except that portion within the drainage area naturally tributary to...