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1

8. SHOSHONE HYDROELECTRIC PLANT, WEST AND SOUTH ELEVATIONS, OFFICE BUILDING ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. SHOSHONE HYDROELECTRIC PLANT, WEST AND SOUTH ELEVATIONS, OFFICE BUILDING TO THE LEFT; VIEW TO THE NORTHEAST. - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

2

1. GENERAL VIEW OF SHOSHONE HYDROELECTRIC PLANT IN GLENWOOD CANYON, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. GENERAL VIEW OF SHOSHONE HYDROELECTRIC PLANT IN GLENWOOD CANYON, VIEW TO THE NORTHEAST ALONG U.S. 6 AND THE COLORADO RIVER. - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

3

JORDAN CREEK STUDY, OWYHEE COUNTY, ID IN 1975-1976  

EPA Science Inventory

A set of 3 intensive surveys was completed on Jordan Creek in Owyhee County, ID (17050108) during August and October 1975 and June 1976. Studies were conducted to determine the water quality condition of the stream and to assess the impact of pollution sources. The study includ...

4

5. SHOSHONE HYDROELECTRIC PLANT, SOUTH AND EAST ELEVATIONS, VIEW TO ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. SHOSHONE HYDROELECTRIC PLANT, SOUTH AND EAST ELEVATIONS, VIEW TO WEST; MACHINE REPAIR SHOP TO THE RIGHT, OFFICE BUILDING AND 115 KV SUBSTATION TO THE LEFT. - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

5

7. SHOSHONE HYDROELECTRIC PLANT, WEST ELEVATION OF MAIN BUILDING TO ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. SHOSHONE HYDROELECTRIC PLANT, WEST ELEVATION OF MAIN BUILDING TO THE LEFT, NORTH ELEVATION OF OFFICE BUILDING TO THE RIGHT, VIEW TO THE EAST. CONCRETE 'PATH' IN FOREGROUND IS THE CONDUIT THROUGH WHICH POWER CABLES RUN FROM THE TRANSFORMERS TO THE 115 KV SUBSTATION. - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

6

4. SHOSHONE HYDROELECTRIC PLANT, SOUTH ELEVATION; TWIN PENSTOCKS AND FOREBAY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. SHOSHONE HYDROELECTRIC PLANT, SOUTH ELEVATION; TWIN PENSTOCKS AND FOREBAY ABOVE THE PLANT; HOIST HOUSE AND NORTH CABLEWAY TOWER ABOVE THE SPILLWAY TO THE RIGHT; TAIL RACE BELOW U.S. HIGHWAY 6 BRIDGE. - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

7

76 FR 11264 - Notice of Realty Action: Proposed Direct Sale of Public Land in Shoshone County, ID  

Federal Register 2010, 2011, 2012, 2013

...sale may be submitted to Field Manager, BLM Coeur d'Alene Field Office, 3815 Schreiber Way, Coeur d'Alene, Idaho 83815. FOR FURTHER INFORMATION...Realty Specialist, at 3815 Schreiber Way, Coeur d'Alene, Idaho 83815 or phone (208)...

2011-03-01

8

78 FR 4377 - Idaho Panhandle National Forests, Coeur d'Alene River Ranger District, Shoshone County, ID...  

Federal Register 2010, 2011, 2012, 2013

...harvest (commercial thin, shelterwood, improvement cut, and seed tree treatments); hazardous fuels treatment (underburning...timber (commercial thin, shelterwood, improvement cuts, and seed tree treatments) and treat hazardous fuels...

2013-01-22

9

WATER QUALITY STATUS REPORT, CONWAY GULCH, CANYON COUNTY, ID, 1981-1982  

EPA Science Inventory

The ID Division of Environment (DOE) conducted a water quality survey of conway Gulch, Canyon County, ID (17050114) from April 1981 through March 1982. A total of 12,880 critical erosion acres are included in the drainage area of Conway Gulch. Baseline suspended sediment loadin...

10

77 FR 52680 - Foreign-Trade Zone 242-Boundary County, ID, Notification of Proposed Production Activity, AREVA...  

Federal Register 2010, 2011, 2012, 2013

...B-67-2012] Foreign-Trade Zone 242--Boundary County, ID, Notification of Proposed...Production Equipment), Bonneville County, ID Boundary County, grantee of FTZ 242, submitted...systems (duty rate ranges from duty-free to 5.7%). Public comment is...

2012-08-30

11

75 FR 50777 - Minidoka Dam Spillway Replacement, Minidoka County, ID  

Federal Register 2010, 2011, 2012, 2013

...Reclamation [INT-FES 10-43] Minidoka Dam Spillway Replacement, Minidoka County...prepared a FEIS on the proposed Minidoka Dam Spillway Replacement. The U.S. Fish...be submitted electronically to minidoka_dam_eis@usbr.gov. FOR FURTHER...

2010-08-17

12

77 FR 51561 - Notice of Temporary Restriction Order for Skinny Dipper Hot Springs, Boise County, ID  

Federal Register 2010, 2011, 2012, 2013

...Temporary Restriction Order for Skinny Dipper Hot Springs, Boise County, ID AGENCY: Bureau...recreational use restriction of Skinny Dipper Hot Springs is in effect on public lands administered...trail from the parking area to Skinny Dipper Hot Springs, and the public lands in Lot...

2012-08-24

13

Predevelopment Water-Level Contours for Aquifers in the Rainier Mesa and Shoshone Mountain area of the Nevada Test Site, Nye County, Nevada  

SciTech Connect

Contaminants introduced into the subsurface of the Nevada Test Site at Rainier Mesa and Shoshone Mountain by underground nuclear testing are of concern to the U.S. Department of Energy and regulators responsible for protecting human health and safety. Although contaminants were introduced into low-permeability rocks above the regional flow system, the potential for contaminant movement away from the underground test areas and into the accessible environment is greatest by ground-water transport. The primary hydrologic control on this transport is evaluated and examined through a series of contour maps developed to represent the water-level distribution within each of the major aquifers underlying the area. Aquifers were identified and their extents delineated by merging and analyzing multiple hydrostratigraphic framework models developed by other investigators from existing geologic information. The contoured water-level distribution in each major aquifer was developed from a detailed evaluation and assessment of available water-level measurements. Multiple spreadsheets that accompany this report provide pertinent water-level and geologic data by well or drill hole. Aquifers are mapped, presented, and discussed in general terms as being one of three aquifer types—volcanic aquifer, upper carbonate aquifer, or lower carbonate aquifer. Each of these aquifer types was subdivided and mapped as independent continuous and isolated aquifers, based on the continuity of its component rock. Ground-water flow directions, as related to the transport of test-generated contaminants, were developed from water-level contours and are presented and discussed for each of the continuous aquifers. Contoured water-level altitudes vary across the study area and range from more than 5,000 feet in the volcanic aquifer beneath a recharge area in the northern part of the study area to less than 2,450 feet in the lower carbonate aquifer in the southern part of the study area. Variations in water-level altitudes within any single continuous aquifer range from a few hundred feet in a lower carbonate aquifer to just more than 1,100 feet in a volcanic aquifer. Flow directions throughout the study area are dominantly southward with minor eastward or westward deviations. Primary exceptions are westward flow in the northern part of the volcanic aquifer and eastward flow in the eastern part of the lower carbonate aquifer. Northward flow in the upper and lower carbonate aquifers in the northern part of the study area is possible but cannot be substantiated because data are lacking. Interflow between continuous aquifers is evaluated and mapped to define major flow paths. These flow paths delineate tributary flow systems, which converge to form the regional ground-water flow system. The implications of these tributary flow paths in controlling transport away from the underground test areas at Rainier Mesa and Shoshone Mountain are discussed. The obvious data gaps contributing to uncertainties in the delineation of aquifers and development of water-level contours are identified and evaluated.

Joseph M. Fenelon; Randell J. Laczniak; and Keith J. Halford

2008-06-24

14

Predevelopment Water-Level Contours for Aquifers in the Rainier Mesa and Shoshone Mountain area of the Nevada Test Site, Nye County, Nevada  

USGS Publications Warehouse

Contaminants introduced into the subsurface of the Nevada Test Site at Rainier Mesa and Shoshone Mountain by underground nuclear testing are of concern to the U.S. Department of Energy and regulators responsible for protecting human health and safety. Although contaminants were introduced into low-permeability rocks above the regional flow system, the potential for contaminant movement away from the underground test areas and into the accessible environment is greatest by ground-water transport. The primary hydrologic control on this transport is evaluated and examined through a series of contour maps developed to represent the water-level distribution within each of the major aquifers underlying the area. Aquifers were identified and their extents delineated by merging and analyzing multiple hydrostratigraphic framework models developed by other investigators from existing geologic information. The contoured water-level distribution in each major aquifer was developed from a detailed evaluation and assessment of available water-level measurements. Multiple spreadsheets that accompany this report provide pertinent water-level and geologic data by well or drill hole. Aquifers are mapped, presented, and discussed in general terms as being one of three aquifer types?volcanic aquifer, upper carbonate aquifer, or lower carbonate aquifer. Each of these aquifer types was subdivided and mapped as independent continuous and isolated aquifers, based on the continuity of its component rock. Ground-water flow directions, as related to the transport of test-generated contaminants, were developed from water-level contours and are presented and discussed for each of the continuous aquifers. Contoured water-level altitudes vary across the study area and range from more than 5,000 feet in the volcanic aquifer beneath a recharge area in the northern part of the study area to less than 2,450 feet in the lower carbonate aquifer in the southern part of the study area. Variations in water-level altitudes within any single continuous aquifer range from a few hundred feet in a lower carbonate aquifer to just more than 1,100 feet in a volcanic aquifer. Flow directions throughout the study area are dominantly southward with minor eastward or westward deviations. Primary exceptions are westward flow in the northern part of the volcanic aquifer and eastward flow in the eastern part of the lower carbonate aquifer. Northward flow in the upper and lower carbonate aquifers in the northern part of the study area is possible but cannot be substantiated because data are lacking. Interflow between continuous aquifers is evaluated and mapped to define major flow paths. These flow paths delineate tributary flow systems, which converge to form the regional ground-water flow system. The implications of these tributary flow paths in controlling transport away from the underground test areas at Rainier Mesa and Shoshone Mountain are discussed. The obvious data gaps contributing to uncertainties in the delineation of aquifers and development of water-level contours are identified and evaluated.

Fenelon, Joseph M.; Laczniak, Randell J.; Halford, Keith J.

2008-01-01

15

77 FR 47593 - Shoshone Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...Broadway, Thermopolis, WY. Written comments should be sent to Olga Troxel, Shoshone National Forest, 808 Meadow Lane, Cody...facilitate entry into the building. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone...

2012-08-09

16

NEWE: A Western Shoshone History.  

ERIC Educational Resources Information Center

One in a series of four histories of native Nevadans, this volume relates the history of the Western Shoshone, or Newe, whose territory included parts of the Great Basin area which extends from southern California to Idaho. Based on the spoken word of tribal elders and research conducted at numerous archives, the history begins with ancient…

Inter-Tribal Council of Nevada, Reno.

17

77 FR 59639 - Bear Lake National Wildlife Refuge, Bear Lake County, ID and Oxford Slough Waterfowl Production...  

Federal Register 2010, 2011, 2012, 2013

...FWS-R1-R-2012-N095; 1265-0000-10137-S3] Bear Lake National Wildlife Refuge, Bear Lake County, ID and Oxford Slough Waterfowl Production...environmental assessment (Draft CCP/EA) for the Bear Lake National Wildlife Refuge (NWR, Refuge), 7...

2012-09-28

18

78 FR 33433 - Bear Lake National Wildlife Refuge, Bear Lake County, ID, and Oxford Slough Waterfowl Production...  

Federal Register 2010, 2011, 2012, 2013

...FWS-R1-R-2013-N048; 12560-0000-10137 S3] Bear Lake National Wildlife Refuge, Bear Lake County, ID, and Oxford Slough Waterfowl Production...the Environmental Assessment (EA) for the Bear Lake National Wildlife Refuge (NWR, refuge), 7...

2013-06-04

19

Phase I Contaminant Transport Parameters for the Groundwater Flow and Contaminant Transport Model of Corrective Action Unit 99: Rainier Mesa/Shoshone Mountain, Nevada Test Site, Nye County, Nevada, Revision 1  

SciTech Connect

This document presents a summary and framework of available transport data and other information directly relevant to the development of the Rainier Mesa/Shoshone Mountain (RMSM) Corrective Action Unit (CAU) 99 groundwater transport model. Where appropriate, data and information documented elsewhere are briefly summarized with reference to the complete documentation.

Nathan Bryant

2008-05-01

20

Shoshone Spirituality Archaeological Interpretation in Southeast Idaho  

SciTech Connect

Tribal people in southeast Idaho sincerely desire that archaeologists include Shoshone concepts of spirituality when investigating archaeological materials and sites. However, most archaeologists and resource managers have little understanding about these concepts and this creates difficulties. We examine two important aspects of the Shoshone soul, Mugua’ and Nabushi’aipe, and discuss how understanding these attributes aid in explaining why certain archaeological remains are considered sacred. A greater understanding of Shoshone spirituality will begin to bridge the needs of both tribal people and archaeologists.

Dean, P. A.; Marler, Clayton Fay

2001-03-01

21

76 FR 3081 - Shoshone Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...held via conference call. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National...Members of the public who wish to participate may do so by calling Olga Troxel, Resource Advisory Committee Coordinator, for...

2011-01-19

22

77 FR 56607 - Shoshone Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...September 19, 2012, at 9 a.m. ADDRESSES: The meeting is being changed to a conference call. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest Supervisor's Office, (307) 578-5164....

2012-09-13

23

76 FR 12317 - Shoshone Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...The meeting will be held at Big Horn Federal Savings, 643 Broadway, Thermopolis, Wyoming. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest Supervisor's Office, (307) 578-5164....

2011-03-07

24

75 FR 62500 - Shoshone Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...The meeting will be held at Big Horn Federal Savings, 643 Broadway, Thermopolis, Wyoming. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest Supervisor's Office, (307) 578-5164....

2010-10-12

25

76 FR 41196 - Shoshone Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...The meeting will be held at Big Horn Federal Savings, 643 Broadway, Thermopolis, Wyoming. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest Supervisor's Office, (307) 578-5164....

2011-07-13

26

Solar Energy System Description Document. Loudoun County Site, Site ID 033, PON 2157.  

National Technical Information Service (NTIS)

The solar heating system for the Loudon County site provides solar preheating of the domestic hot water supply for the Charles S. Monroe Vocational-Tehnical School at Leesburg, Loudon County, Virginia. In this area the predominant method of providing hot ...

1977-01-01

27

Public Health Assessment: Jackson Park Housing Complex (JPHC) Kitsap County, Washington. EPA Facility ID: WA3170090044  

National Technical Information Service (NTIS)

Jackson Park Housing Complex (JPHC), located in central Kitsap County, Washington, consists of an off-site family housing area for military personnel stationed in the Bremerton area and Naval Hospital Bremerton (NHB), located immediately north of the mili...

2008-01-01

28

Health Consultation: Little Black Creek Sediments, Muskegon County, Michigan. EPA Facility ID: MID006031348.  

National Technical Information Service (NTIS)

In the fall of 2004, the Muskegon County Health Department requested assistance from the Michigan Department of Community Health (MDCH) in evaluating the public health implications of exposure to sediments in two Muskegon-area creeks, Ryerson Creek and Li...

2006-01-01

29

76 FR 78940 - Minidoka National Wildlife Refuge, Blaine, Cassia, Minidoka, and Power Counties, ID...  

Federal Register 2010, 2011, 2012, 2013

...miles northeast of Rupert, ID, in the Snake River Plain, at approximately 4,200...historically comprised of a portion of the Snake River surrounded by an expansive sea of...the Bureau of Reclamation impounded the Snake River and created Lake Walcott to...

2011-12-20

30

75 FR 8744 - Notice of Proposed Issuance of Recordable Disclaimer of Interest; Jerome County, ID  

Federal Register 2010, 2011, 2012, 2013

...County approximately 17 miles northeast of Twin Falls, Idaho. The Consolidated Natural...Hunt Road located 17 miles northeast of Twin Falls, Idaho. This parcel, identified...of land intersects the northerly line of Twin Falls North Side Canal. The above...

2010-02-25

31

75 FR 55539 - Shoshone Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...The meeting will be held at Big Horn Federal Savings, 643 Broadway, Thermopolis, WY. Written comments should be sent to Olga Troxel, Shoshone National Forest, 808 Meadow Lane, Cody, WY 82414. Comments may also be sent via e-mail to...

2010-09-13

32

76 FR 34034 - Shoshone Resource Advisory Committee Agency  

Federal Register 2010, 2011, 2012, 2013

...held via conference call. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National...Members of the public who wish to participate may do so by calling Olga Troxel, Resource Advisory Committee Coordinator, for...

2011-06-10

33

75 FR 28280 - Deadline for Submission of Applications To Be Included on the Roll of Western Shoshone...  

Federal Register 2010, 2011, 2012, 2013

...Applications To Be Included on the Roll of Western Shoshone Identifiable Group of Indians...by the Indian Claims Commission to the Western Shoshone Identifiable Group of Indians...applications to Bureau of Indian Affairs Western Shoshone, Tribal Government...

2010-05-20

34

Superfund Record of Decision: Tower Chemical Company, Clearmont (Lake County), FL, September 14, 2006. EPA ID: FLD004065546.  

National Technical Information Service (NTIS)

The Tower Chemical Company (TCC) Site (the Site) in Lake County, Florida is an approximately 15-acre abandoned pesticide manufacturing facility. From 1957 to 1981, TCC manufactured, produced and stored various pesticides. TCC discharged acidic wastewater ...

2006-01-01

35

75 FR 79018 - Notice of Realty Action: Proposed Sale of Public Lands in Bear Lake County, ID  

Federal Register 2010, 2011, 2012, 2013

...County, Idaho, are proposed for sale under the authority...during processing of the proposed sale. The BLM Pocatello...laws, including the mining laws, except the...encumbrances or other claims relating to the identified...environmental analysis of the proposed sale, comments...

2010-12-17

36

77 FR 15122 - Te-Moak Tribe of Western Shoshone- Ordinance Pursuant to United States Code, Legalizing and...  

Federal Register 2010, 2011, 2012, 2013

...Bureau of Indian Affairs Te-Moak Tribe of Western Shoshone-- Ordinance Pursuant to United...the Amendment to the Te-Moak Tribe of Western Shoshone Indians Ordinance Pursuant to...liquor within the jurisdiction of Te-Moak Western Shoshone Tribe's Colonies and...

2012-03-14

37

National Dam Inspection Program. Bunnell's Pond Dam (NDI ID Number PA-00170, DER ID Number 64-29), Delaware River Basin, Carley Brook, Wayne County, Pennsylvania. Phase I Inspection Report.  

National Technical Information Service (NTIS)

The purpose of the inspection is to determine if the dam constitutes a hazard to human life or property. Bunnell's Pond Dam is located on Carley Brook in Honesdale Borough, Wayne County, Pennsylvania. The overall appearance of the dam and appurtenant stru...

F. Futchko

1981-01-01

38

National Dam Inspection Program. Duck Harbor Pond Dam (NDI ID Number PA-00144, DER ID Number 64-54), Delaware River Basin, Little Equinunk Creek, Wayne County, Pennsylvania. Phase I Inspection Report.  

National Technical Information Service (NTIS)

The purpose of the inspection is to determine if the dam constitutes a hazard to human life or property. Duck Harbor Pond Dam is located on Little Equinunk Creek in Damascus Township, Wayne County, Pennsylvania. Downstream conditions indicate that a signi...

F. Futchko

1981-01-01

39

Completion Report for Well ER-12-4, Corrective Action Unit 99: Rainier Mesa - Shoshone Mountain (includes Errata Sheet)  

SciTech Connect

Well ER-12-4 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in May 2005, as part of a hydrogeologic investigation program for the Rainier Mesa-Shoshone Mountain Corrective Action Unit in the north-central portion of the Nevada Test Site. The well is located on Rainier/Aqueduct Mesa, northwest of Yucca Flat, within Area 12 of the Nevada Test Site. The well provided information regarding the radiological and physical environment near underground nuclear tests conducted in U12t Tunnel, information on the pre-Tertiary rocks in the area, and depth to the regional water table.

U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Bechtel Nevada

2006-05-01

40

Completion Report for Well ER-16-1 Corrective Action Unit 99: Rainier Mesa - Shoshone Mountain  

SciTech Connect

Well ER-16-1 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. The well was drilled in June and July 2005 as part of a hydrogeologic investigation program for the Rainier Mesa-Shoshone Mountain Corrective Action Unit, Number 99. The overall purpose of the well was to gather subsurface data to better characterize the hydrogeology of the Shoshone Mountain area, especially in the older Tertiary and pre-Tertiary strata. The main 46.99-centimeter hole was drilled to a depth of 702.9 meters and cased with 33.97-centimeter casing to 663.7 meters. The hole diameter was then decreased to 31.1 centimeters, and the well was drilled to total depth of 1,220.7 meters. A completion string set at the depth of 1,162.4 meters consisted of 13.97-centimeter stainless-steel casing, with one continuous slotted interval open to the lower carbonate aquifer. The fluid level in the borehole soon dropped, so the borehole was deepened in July 2006. To deepen the borehole, the slotted section was cemented and a 12.1-centimeter hole was drilled through the bottom of the completion string to the new total depth of 1,391.7 meters, which is 171.0 meters deeper than the original borehole. A string of 6.03-centimeter carbon-steel tubing with one continuous slotted interval at 1,361.8 to 1,381.4 meters, and open to the lower carbonate aquifer, was installed in the well with no gravel packing or cement, to serve as a monitoring string. Data gathered during and shortly after hole construction include composite drill cuttings samples collected every 3 meters (extra cuttings samples were collected from the Paleozoic rocks for paleontological analyses), sidewall core samples from 37 depths, various geophysical logs, and water level measurements. These data indicate that the well penetrated 646.8 meters of Tertiary volcanic rocks and 744.9 meters of Paleozoic dolomite, quartzite, shale, and limestone. Three weeks after the monitoring string was installed, the water level was tagged at the drill hole depth of 1,271.9 meters, which equates to an estimated elevation of 761.7 meters, accounting for the borehole angle.

NSTec Geology Services

2006-12-01

41

National Dam Inspection Program. Fawn Lake Dam,(ID Number PA00693). Schuylkill River Basin, Plum Creek, Schuylkill County, Pennsylvania. Phase I Inspection Report.  

National Technical Information Service (NTIS)

Fawn Lake Dam is owned by the Lake Wynonah Property Owners Association and is located in South Mannheim Township in Schuylkill County, Pennsylvania. The dam was designed by the original owner, American Realty Service Corporation of Memphis, Tennessee. The...

1978-01-01

42

Public Health Assessment for Dismal Swamp Site (a/k/a Woodbrook Road Dump) South Plainfield, Middlexsex County, New Jersey. EPA Facility ID: NJSFN0204260.  

National Technical Information Service (NTIS)

The Dismal Swamp site (a.k.a. the Woodbrook Road Dump site) is an inactive, non-permitted dumping area located near the intersection of Woodbrook and Metuchen Roads in South Plainfield, Middlesex County, New Jersey. The approximately 70 acre site is compr...

2003-01-01

43

I.D. 1730-1-00, Park Freeway and Spur, (North Sherman Boulevard to North Twelfth Street), City of Milwaukee, Milwaukee County, Wisconsin.  

National Technical Information Service (NTIS)

The project under consideration is the Park Freeway and Spur, a 2.7 mile portion of the Milwaukee County Expressway System. The western terminus of this project is at Sherman Boulevard between North Avenue and Meinecke Avenue, and is designed to connect w...

1973-01-01

44

Public Health Assessment for Big John Salvage - Hoult Road Site, Fairmont, Marion County, West Virginia, March 14, 2005. EPA Facility ID: WVD054827944.  

National Technical Information Service (NTIS)

The Big John Salvage - Hoult Road (Big John Salvage) site is an abandoned salvage facility in Fairmont, Marion County, West Virginia. The site is located in a mixed industrial/residential area. The site is approximately 20 acres in size and lies along the...

2005-01-01

45

Public Health Assessment for Old Roosevelt Field Contaminated Groundwater Area Garden City, Naasau County, New York. EPA Facility ID: NYSFN0204234.  

National Technical Information Service (NTIS)

The former Roosevelt Air Field Hanger site, now occupied by a shopping mall and office buildings, is at the intersection of Old Country Road and Clinton Road in Garden City, Nassau County, New York. The Old Roosevelt Field Contaminated Groundwater Area (O...

2004-01-01

46

Completion Report for Well ER-12-3 Corrective Action Unit 99: Rainier Mesa - Shoshone Mountain  

SciTech Connect

Well ER-12-3 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. The well was drilled in March and April 2005 as part of a hydrogeologic investigation program for the Rainier Mesa-Shoshone Mountain Corrective Action Unit. The overall purpose of the well was to gather subsurface data to better characterize the hydrogeology of central Rainier Mesa, especially in the older Tertiary volcanic rocks and Paleozoic sedimentary rocks. The main 47.0-centimeter hole was drilled to a depth of 799.2 meters and cased with 33.97-centimeter casing to 743.1 meters. The hole diameter was then decreased to 31.1 centimeters, and the well was drilled to a total depth of 1,496.0 meters. The completion string consisted of 13.97-centimeter stainless steel casing, with two slotted intervals open to the lower carbonate aquifer, suspended from 19.37-centimeter carbon steel casing. A piezometer string was installed outside the 33.97-centimeter casing to a depth of 467.1 meters to monitor a zone of perched water within the Tertiary volcanic section. Data gathered during and shortly after hole construction include composite drill cuttings samples collected every 3 meters (extra cuttings samples were collected from the Paleozoic rocks for paleontological analyses), sidewall core samples from 35 depths, various geophysical logs, and water level measurements. These data indicate that the well penetrated 674.2 meters of Tertiary volcanic rocks and 821.7 meters of Paleozoic dolomite and limestone. Forty-nine days after the well was completed, but prior to well development and testing, the water level inside the main hole was tagged at the depth of 949.1 meters, and the water level inside the piezometer string was tagged at 379.9 meters.

U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Bechtel Nevada Corporation

2006-05-01

47

Boulder ID  

NSDL National Science Digital Library

After some in and out of class practice with mineral and rock id, students are divided into groups of about 5 and taken to locations where boulders and cobbles are used as decorative landscaping (usually adjacent to streets or on short slopes). This seems to work best if class sizes are about 25 or less - then instructors can keep track of groups in an area. Groups are given an area about 5 feet wide and 25 long (enough for several hundred cobbles/boulders) and told to identify 6-12 rocks of different types (at least 2 each if only doing Ig, Met, Sed.- more if rock names expected). 1.) In the first stage groups are given a fairly long time (~20-25 minutes) to pick and identify rocks with flags and markers. This seems like a long time and normally they can quickly flag and name the easiest rocks in their area. However, they only get one point for each rock correctly identified at this stage. 2.) In the second stage groups get 10 minutes to inspect all other groups' areas and mark those rocks they think other groups INCORRECTLY identified. They are allowed to send one person from their group to inspect each of the other groups' areas. Their group gets 5 pts for each correctly mis-identified rock of another group. 3.) In the third stage, groups can defend their identifications to the instructor/TA and get 10 points if they prove that another group flagged/id'd one of their identifications incorrectly - the mistaken group gets docked 10 points. The key to this exercise is that in the first stage some of the students should realize that they get many more points for making other groups mis-identify their rocks, and that all of their own group members should be trained to have enough expertise to identify tricky or difficult rocks. This is the reason for the excess time at the first stage, for training, review, and typically the group will change their chosen rocks to include the most difficult ones rather than the easiest. Should groups not realize this - the instructor might want to prompt them.Students are allowed Rock charts, cheat sheets, etc. at the instructors decision.

Hurst, Steve

48

Anomalously high K in soils of the Shoshone Range, Nevada USA  

NASA Astrophysics Data System (ADS)

The Shoshone Range in north-central Nevada is composed of welded and non-welded silicic ash flow tuffs, early Oligocene to early Miocene in age. We analyzed soil properties along an elevational gradient and ammonium acetate-exchangeable K exceeded 50% of the cation exchange capacity in some samples. To understand these anomalously high exchangeable K levels, we compared the chemistry of one Shoshone Range soil and parent tuff with the chemistry of 20 different soils and associated parent rock in 5 western states. Soil from the Shoshone Range stands out among the other sites in both the large molar proportion of ammonium acetate exchangeable K and the large molar proportion of K relative to Ca + Mg + Na in the total soil digest. Shoshone parent rock also has very high ratios of K:Mg, K:Si, and K:Ti relative to the other parent rocks. These data suggest that Shoshone soils are youthful with minimal weathering losses of K. Moreover, x-ray diffraction indicates little neogenesis of secondary K-bearing clays, which would sequester K against such extraction. Such high soil K levels have been shown to reduce root uptake of Mg and P and affect plant growth.

Blank, R.; Rau, B.

2012-12-01

49

78 FR 35602 - Coeur d'Alene Basin Restoration Plan, Kootenai, Shoshone and Benewah Counties, Idaho  

Federal Register 2010, 2011, 2012, 2013

...Land Management Fish and Wildlife Service Coeur d'Alene Basin Restoration Plan, Kootenai...States Department of Agriculture (USDA), Coeur d'Alene Indian Tribe (Tribe), and...You may submit comments related to the Coeur d'Alene Basin Restoration Plan by...

2013-06-13

50

ID management among clouds  

Microsoft Academic Search

In the following years, the desktop-based applications will be changed to cloud computing gradually. Since all users' profile and context data will be stored on the service supplier side based on their ID. ID is becoming a security bottleneck: attackers can trace all other information via user ID. Increasingly, a simple service may be involved in a chain of service

Xin Huang; Tingting Zhang; Yifan Hou

2009-01-01

51

Magnetotelluric Data, Rainier Mesa/Shoshone Mountain, Nevada Test Site, Nevada.  

SciTech Connect

The United States Department of Energy (DOE) and the National Nuclear Security Administration (NNSA) at their Nevada Site Office (NSO) are addressing ground-water contamination resulting from historical underground nuclear testing through the Environmental Management (EM) program and, in particular, the Underground Test Area (UGTA) project. From 1951 to 1992, 828 underground nuclear tests were conducted at the Nevada Test Site northwest of Las Vegas. Most of these tests were conducted hundreds of feet above the ground-water table; however, more than 200 of the tests were near or within the water table. This underground testing was limited to specific areas of the Nevada Test Site, including Pahute Mesa, Rainier Mesa/Shoshone Mountain, Frenchman Flat, and Yucca Flat. One issue of concern is the nature of the somewhat poorly constrained pre-Tertiary geology, and its effects on ground-water flow. Ground-water modelers would like to know more about the hydrostratigraphy and geologic structure to support a hydrostratigraphic framework model that is under development for the Rainier Mesa/Shoshone Mountain Corrective Action Unit (Bechtel Nevada, 2006). During 2005, the U.S. Geological Survey (USGS), in cooperation with the DOE and NNSA-NSO, collected and processed data from twenty-six magnetotelluric (MT) and audio-magnetotelluric (AMT) sites at the Nevada Test Site. The 2005 data stations were located on and near Rainier Mesa and Shoshone Mountain to assist in characterizing the pre-Tertiary geology in those areas. These new stations extend the area of the hydrogeologic study previously conducted in Yucca Flat. This work will help refine what is known about the character, thickness, and lateral extent of pre-Tertiary confining units. In particular, a major goal has been to define the upper clastic confining unit (UCCU – late Devonian to Mississippian-age siliciclastic rocks assigned to the Eleana Formation and Chainman Shale) from the Yucca Flat area and west towards Shoshone Mountain, to Buckboard Mesa in the south, and onto Rainier Mesa in the north. Subsequent interpretation will include a three-dimensional (3-D) character analysis and a two-dimensional (2-D) resistivity model. The purpose of this report is to release the MT sounding data for the twenty-six stations shown in figure 1. No interpretation of the data is included here.

Jackie M. Williams; Jay A. Sampson; Brian D. Rodriguez; and Theodore H. Asch.

2006-11-03

52

Public Health Assessment. Libby Asbestos NPL Site. OU4: Screening Plant, Export Plant, Town of Libby, and Affected Libby Valley Residential and Commercial Properties Lincoln County, Montana, Region 8. EPA Facility ID: MT0009083840.  

National Technical Information Service (NTIS)

Libby is the county seat of Lincoln County, in northwest Montana. Vermiculite was mined from Zonolite Mountain near Libby from the early 1920s until 1990 and was processed for export in and around the town of Libby. The vermiculite mined in Libby is conta...

2002-01-01

53

The ID effect on youth access to cigarettes  

PubMed Central

Objective: To estimate the effect on cigarette sales rates when minors present identification (ID). Design: Controlled experiment in which minors attempting to purchase cigarettes either carried a valid photo ID (documenting they were minors) or carried no ID, and were instructed to show the ID or admit having no ID if the clerk requested proof of age. Setting: Census of retail stores in six urban and suburban Colorado counties. Subjects: Retail cigarette clerks, uninformed of the study. Main outcome measures: Relative risk (RR) of cigarette sale to a minor when ID was requested and presented versus requested but not presented. Results: When clerks requested ID, sales were more than six times as frequent if minors presented ID than if they did not (12.2% v 2.0%, RR 6.2, p < 0.0001). The relative risk remained substantially unchanged under adjustment for demographic and circumstantial covariates. Conclusions: Presentation of photo ID in compliance checks increases illegal cigarette sales to minors. The impact may vary among states or locales and depends strongly on how often clerks request proof of age. Clerk training and responsible cigarette sales practices should include age calculations from photo ID. Programmes relying on investigative purchase attempts to estimate actual rates of cigarette sales to minors should ascertain and replicate local ID presenting behaviours that minors typically use during genuine attempts to buy cigarettes.

Levinson, A; Hendershott, S; Byers, T

2002-01-01

54

Metal and Nonmetal Mine Safety and Health Report of Investigation: Surface Nonmetal Mine (Limestone) Fatal Powered Haulage Accident, June 21, 2012, T H Kinsella Incorporated, Kinsella Quarry and Mill, Fayettesville, Onondaga County, New York. ID No. 30-01279.  

National Technical Information Service (NTIS)

Kinsella Quarry and Mill, a surface limestone mine, owned and operated by T H Kinsella Incorporated, is located in Fayetteville, Onondaga County, New York. Thomas Kinsella, President, and Allen Curtis, Vice-President are the principal operating officials....

2012-01-01

55

Public Health Assessment: White Swan Cleaners/Sun Cleaners Area Groundwater Contamination (a/k/a White Swan Laundry and Cleaners incorporated) Wall Township, Momouth County, New Jersey. EPA Facility ID: NJSFN0204241.  

National Technical Information Service (NTIS)

On April 30, 2003, the United States Environmental Protection Agency proposed to add the White Swan Cleaners/Sun Cleaners Area Ground Water Contamination site, Wall Township, Monmouth County, New Jersey to the National Priorities 11st. Volatile organic co...

2007-01-01

56

Public Health Assessment for Naval Support Activity, Mechanicsburg (Aliases: Navy Ships Parts Control Center and Naval Inventory Control Point) Mechanicsburg, Cumberland County, Pennsylvania. EPA Facility ID: PA3170022104, June 6, 2002.  

National Technical Information Service (NTIS)

ATSDR evaluated the potential for contamination at the Naval Support Activity, Mechanicsburg (NSA) to cause harm to human health. The NSA, a naval support facility, encompasses 824 acres of land in Hampden Township and Cumberland County, Pennsylvania. In ...

2002-01-01

57

ETR BASEMENT, TRA642, INTERIOR. BASEMENT. CUBICLE INTERIOR (SEE PHOTOS ID33G101 ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ETR BASEMENT, TRA-642, INTERIOR. BASEMENT. CUBICLE INTERIOR (SEE PHOTOS ID-33-G-101 AND ID-33-G-102) WITH TANK AND SODIUM-RELATED APPARATUS. CAMERA STANDS BEFORE ROLL-UP DOOR SHOWN IN PHOTO ID-33-G-101. INL NEGATIVE NO. HD24-3-3. Mike Crane, Photographer, 11/2000 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

58

Tribal Wind Assessment by the Eastern Shoshone Tribe of the Wind River Reservation  

SciTech Connect

The Tribes, through its consultant and advisor, Distributed Generation Systems (Disgen) -Native American Program and Resources Division, of Lakewood CO, assessed and qualified, from a resource and economic perspective, a wind energy generation facility on tribal lands. The goal of this feasibility project is to provide wind monitoring and to engage in preproject planning activities designed to provide a preliminary evaluation of the technical, economic, social and environmental feasibility of developing a sustainable, integrated wind energy plan for the Eastern Shoshone and the Northern Arapahoe Tribes, who resides on the Wind River Indian Reservation. The specific deliverables of the feasibility study are: 1) Assessments of the wind resources on the Wind River Indian Reservation 2) Assessments of the potential environmental impacts of renewable development 3) Assessments of the transmission capacity and capability of a renewable energy project 4) Established an economic models for tribal considerations 5) Define economic, cultural and societal impacts on the Tribe

Pete, Belvin; Perry, Jeremy W.; Stump, Raphaella Q.

2009-08-28

59

Simple estimation of minimum unsaturated contaminant travel times at Rainier Mesa and Shoshone Mountain, Nevada Test Site  

NASA Astrophysics Data System (ADS)

In the unsaturated zone the fastest travel times frequently occur via preferential flow that bypasses the soil/rock matrix. Experimental data provide compelling evidence that minimum solute travel times through preferential paths depend primarily on whether water supply is continuous versus non-continuous in time, with little influence from matrix hydraulic properties. We employ a simple model based on this "source- responsive" paradigm to estimate minimum preferential travel times to the regional water table for nonreactive radionuclides at Rainier Mesa and Shoshone Mountain within the Nevada Test Site. The radionuclides at the site originate from underground nuclear testing within a ~1-km-thick unsaturated zone. Contaminated sources at Rainier Mesa and Shoshone Mountain that are continuously supplied include ponded water in certain tunnels, filled detention basins, and partially-filled boreholes with detonation cavities. Tunnels without ponding and unfilled detonation cavities are considered non-continuous sources supplied by percolation of precipitation. Decades of geological and hydrological characterizations provide the foundation for establishing preferential flow as a viable transport mechanism at Rainier Mesa and Shoshone Mountain Our estimated minimum travel times via preferential flow for Rainier Mesa are one to two months for a continuously-supplied source and tens to hundreds of years for a non-continuous source. Previous studies in the scientific literature conducted isotopic analysis of fracture water collected in tunnels at Rainier Mesa that indicated transit times for 400 m of transport from land surface to tunnel levels of one to 40 years. Four monitoring wells in the carbonate aquifer have not detected radionuclide levels above the drinking water standards at Rainier Mesa. Travel times for both the continuously and non-continuously supplied sources at Shoshone Mountain are twice the Rainier Mesa estimates, resulting from longer transport distances and less precipitation. A shale confining unit at Shoshone Mountain may cause a transition from preferential to matrix dominated flow, increasing estimated transport times to more than a thousand years. Concentrations of radionuclides above the drinking water standard have not been detected in a deep well or in springs at Shoshone Mountain. Preliminary results from our analysis indicate the potentially rapid nature of unsaturated-zone preferential transport (despite a semi-arid climate) for continuous sources and highlight the value of a simple modeling approach to complement traditional, more complex flow simulation approaches for contaminant travel time estimation.

Ebel, B. A.; Nimmo, J. R.

2008-12-01

60

AFRD WAREHOUSE, SOUTH SIDE. FACING NORTH. METAL AWNING ALONG LENGTH ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

AFRD WAREHOUSE, SOUTH SIDE. FACING NORTH. METAL AWNING ALONG LENGTH OF BUILDING AND VERTICAL METAL SIDING ARE ALTERATIONS MAD BY THE AFRD. - Minidoka Relocation Center Warehouse, 111 South Fir Street, Shoshone, Lincoln County, ID

61

4. Anode Building. View is to the east. This facility, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Anode Building. View is to the east. This facility, which was used for the cleaning and manufacture of anodes, was documented prior to demolition in 1993. - Sullivan Electrolytic Zinc Plant, Government Gulch, Kellogg, Shoshone County, ID

62

3. Right side of Zinc Plant, from Cell Room midpoint ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Right side of Zinc Plant, from Cell Room midpoint to Plant Office (foreground) and #5 Roaster and Concentrate Handling (background). View is to the east. - Sullivan Electrolytic Zinc Plant, Government Gulch, Kellogg, Shoshone County, ID

63

2. Left side of Zinc Plant, from packless Cooling Tower ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Left side of Zinc Plant, from packless Cooling Tower to midpoint of Cell Room, with majority of Upper Plant in view. View is to the east. - Sullivan Electrolytic Zinc Plant, Government Gulch, Kellogg, Shoshone County, ID

64

127. COTTONWOOD CUT AREA, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

127. COTTONWOOD CUT AREA, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; NORTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

65

128. COTTONWOOD CUT, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

128. COTTONWOOD CUT, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; NORTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

66

108. MURTAUGH LAKE HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

108. MURTAUGH LAKE HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; OVERALL VIEW SOUTH. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

67

107. MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

107. MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; WEST VIEW OF LAKE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

68

100. MURTAUGH LAKE HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

100. MURTAUGH LAKE HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; SOUTH VIEW OF HEADGATES. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

69

125. COTTONWOOD CUT AREA, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

125. COTTONWOOD CUT AREA, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; SOUTH VIEW OF CANAL. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

70

IDS Transfer from Overexpressing Cells to IDS-Deficient Cells  

Microsoft Academic Search

Iduronate sulfatase (IDS) is responsible for mucopolysaccharidosis type II, a rare recessive X-linked lysosomal storage disease. The aim of this work was to test the ability of overexpressing cells to transfer IDS to deficient cells. In the first part of our work, IDS processing steps were compared in fibroblasts, COS cells, and lymphoblastoid cell lines and shown to be identical:

G. Millat; R. Froissart; I. Maire; D. Bozon

1997-01-01

71

Successful I.D. Encounters.  

ERIC Educational Resources Information Center

Instructional Development (I.D.) encounters are dependent for success on such variables as power, politics, promotion, and organizational placement. I.D. consultants must be aware of power bases or orientation of other personnel and clients, e.g., these four "power personalities" which affect their efforts in managing I.D. encounters: the gate…

Poorman, Margaret J.

72

75 FR 22695 - Establishment of Class E Airspace; Bonners Ferry, ID  

Federal Register 2010, 2011, 2012, 2013

...establish Class E airspace at Bonners Ferry, ID, to accommodate aircraft using a new Area Navigation (RNAV) Global Positioning System (GPS) Standard Instrument Approach Procedure (SIAP) at Boundary County Airport. This will improve the...

2010-04-30

73

Magnetotelluric Data, Rainier Mesa/Shoshone Mountain, Nevada Test Site, Nevada  

USGS Publications Warehouse

Introduction: The United States Department of Energy (DOE) and the National Nuclear Security Administration (NNSA) at their Nevada Site Office (NSO) are addressing ground-water contamination resulting from historical underground nuclear testing through the Environmental Management (EM) program and, in particular, the Underground Test Area (UGTA) project. During 2005, the U.S. Geological Survey (USGS), in cooperation with the DOE and NNSA-NSO, collected and processed data from twenty-six magnetotelluric (MT) and audio-magnetotelluric (AMT) sites at the Nevada Test Site. The 2005 data stations were located on and near Rainier Mesa and Shoshone Mountain to assist in characterizing the pre-Tertiary geology in those areas. These new stations extend the area of the hydrogeologic study previously conducted in Yucca Flat. The MT data presented in this report will help refine what is known about the character, thickness, and lateral extent of pre Tertiary confining units. Subsequent interpretation will include a three dimensional (3 D) character analysis and a two-dimensional (2 D) resistivity model. The purpose of this report is to release the MT sounding data. No interpretation of the data is included here.

Williams, Jackie M.; Sampson, Jay A.; Rodriguez, Brian D.; Asch, Theodore H.

2006-01-01

74

13. TIP TOP MINE. WOODEN STRUCTURE VISIBLE IN ID31C12 ISIN ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. TIP TOP MINE. WOODEN STRUCTURE VISIBLE IN ID-31-C-12 ISIN UPPER LEFT. ALSO VISIBLE ARE TWO VERTICALLY BURIED LOGS ASSOCIATED WITH CABLES, ONE OF WHICH IS VISIBLE IN LOWER RIGHT. CAMERA POINTED SOUTH. - Florida Mountain Mining Sites, Tip Top Mine, West face Florida Mountain, approximately 150 feet below summit, Silver City, Owyhee County, ID

75

40. CALCINER CELL SECTIONS. TOGETHER WITH HAER ID33C37 ILLUSTRATES COMPLEXITY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. CALCINER CELL SECTIONS. TOGETHER WITH HAER ID-33-C-37 ILLUSTRATES COMPLEXITY OF PIPING. INEEL DRAWING NUMBER 200-0633-00-287-106446. FLUOR NUMBER 5775-CPP-P-51. - Idaho National Engineering Laboratory, Old Waste Calcining Facility, Scoville, Butte County, ID

76

39. CALCINER CELL PLANS. TOGETHER WITH HAER ID33C37 ILLUSTRATES COMPLEXITY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

39. CALCINER CELL PLANS. TOGETHER WITH HAER ID-33-C-37 ILLUSTRATES COMPLEXITY OF PIPING. INEEL DRAWING NUMBER 200-0633-00-287-106445. FLUOR NUMBER 5775-CPP-633-P-50 - Idaho National Engineering Laboratory, Old Waste Calcining Facility, Scoville, Butte County, ID

77

Health assessment for Bunker Hill Site, Kellog, Shoshone County, Idaho, Region 10. CERCLIS No. IDD048340921. Preliminary report  

SciTech Connect

The Bunker Hill site is on the National Priorities List. Mining and smelting operations have occurred in the area (Silver Valley) since the 1880s. Contamination found within the study area include: lead (33,000 ppm in surface soils, 2.6 ppm in surface water, 11,400 ppm in sediments, 90 ppm in mammalian tissue, and 600 ppb in ground water); cadmium (319 ppm in surface soils, 0.95 ppm in surface water, 51 ppm in sediments, 23 ppm in mammalian tissue, and 250 ppb in ground water); cadmium 319 ppm surface soils, 0.95 ppm in surface water, 51 ppm in sediments, 23 ppm in mammalian tissues, and 250 ppb in ground water; zinc (26,800 ppm in surface soil, 35 ppm in surface water, 7,550 ppm in sediments, and 132,000 ppb in ground water), and polychlorinated biphenyls (1.06 ppb in surface water). The site is of public health concern because human exposure to heavy metals is probably occurring via ingestion, dermal, or inhalation exposure to contaminated surface soils, mine wastes and tailings, surface waters, or contaminated foodstuffs.

Not Available

1989-01-06

78

Corrective Action Investigation Plan for Corrective Action Unit 99: Rainier Mesa/Shoshone Mountain, Nevada Test Site, Nevada, Rev. No. 0  

SciTech Connect

This Corrective Action Investigation Plan (CAIP) was developed for Corrective Action Unit (CAU) 99, Rainier Mesa/Shoshone Mountain. The CAIP is a requirement of the ''Federal Facility Agreement and Consent Order'' (FFACO) agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense (DoD) (FFACO, 1996). The FFACO addresses environmental restoration activities at U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) facilities and sites including the underground testing area(s) of the Nevada Test Site (NTS). This CAIP describes the investigation activities currently planned for the Rainier Mesa/Shoshone Mountain CAU. These activities are consistent with the current Underground Test Area (UGTA) Project strategy described in Section 3.0 of Appendix VI, Revision No. 1 (December 7, 2000) of the FFACO (1996) and summarized in Section 2.1.2 of this plan. The Rainier Mesa/Shoshone Mountain CAU extends over several areas of the NTS (Figure 1-1) and includes former underground nuclear testing locations in Areas 12 and 16. The area referred to as ''Rainier Mesa'' includes the geographical area of Rainier Mesa proper and the contiguous Aqueduct Mesa. Figure 1-2 shows the locations of the tests (within tunnel complexes) conducted at Rainier Mesa. Shoshone Mountain is located approximately 20 kilometers (km) south of Rainier Mesa, but is included within the same CAU due to similarities in their geologic setting and in the nature and types of nuclear tests conducted. Figure 1-3 shows the locations of the tests conducted at Shoshone Mountain. The Rainier Mesa/Shoshone Mountain CAU falls within the larger-scale Rainier Mesa/Shoshone Mountain Investigation Area, which also includes the northwest section of the Yucca Flat CAU as shown in Figure 1-1. Rainier Mesa and Shoshone Mountain lie adjacent to the Timber Mountain Caldera Complex and are composed of volcanic rocks that erupted from the caldera as well as from more distant sources. This has resulted in a layered volcanic stratigraphy composed of thick deposits of welded and nonwelded ash-flow tuff and lava flows. These deposits are proximal to the source caldera and are interstratified with the more distal facies of fallout tephra and bedded reworked tuff from more distant sources. In each area, a similar volcanic sequence was deposited upon Paleozoic carbonate and siliciclastic rocks that are disrupted by various thrust faults, normal faults, and strike-slip faults. In both Rainier Mesa (km) to the southwest, and Tippipah Spring, 4 km to the north, and the tunnel complex is dry. Particle-tracking simulations performed during the value of information analysis (VOIA) (SNJV, 2004b) indicate that most of the regional groundwater that underlies the test locations at Rainier Mesa and Shoshone Mountain eventually follows similar and parallel paths and ultimately discharges in Death Valley and the Amargosa Desert. Particle-tracking simulations conducted for the regional groundwater flow and risk assessment indicated that contamination from Rainier Mesa and Shoshone Mountain were unlikely to leave the NTS during the 1,000-year period of interest (DOE/NV, 1997a). It is anticipated that CAU-scale modeling will modify these results somewhat, but it is not expected to radically alter the outcome of these previous particle-tracking simulations within the 1,000-year period of interest. The Rainier Mesa/Shoshone Mountain CAIP describes the corrective action investigation (CAI) to be conducted at the Rainier Mesa/Shoshone Mountain CAU to evaluate the extent of contamination in groundwater due to the underground nuclear testing. The CAI will be conducted by the UGTA Project, which is part of the NNSA/NSO Environmental Restoration Project (ERP). The purpose and scope of the CAI are presented in this section, followed by a summary of the entire document.

John McCord

2004-12-01

79

Successful I.D. Encounters.  

National Technical Information Service (NTIS)

Instructional Development (I.D.) encounters are dependent for success on such variables as power, politics, promotion, and organizational placement, I.D. consultants must be aware of power bases or orientation of other personnel and clients, e.g., these f...

M. J. Poorman

1979-01-01

80

Estimation of unsaturated zone traveltimes for Rainier Mesa and Shoshone Mountain, Nevada Test Site, Nevada, using a source-responsive preferential-flow model  

Microsoft Academic Search

Traveltimes for contaminant transport by water from a point in the unsaturated zone to the saturated zone are a concern at Rainier Mesa and Shoshone Mountain in the Nevada Test Site, Nevada. Where nuclear tests were conducted in the unsaturated zone, contaminants must traverse hundreds of meters of variably saturated rock before they enter the saturated zone in the carbonate

Brian A. Ebel; John R. Nimmo

2009-01-01

81

SCADA Forensics with Snort IDS  

Microsoft Academic Search

This paper is a research in progress paper outlining an approach using open source IDS (Snort) and honeypot (nepenthes, honeyd) technologies to create a resilient layered defensive approach for SCADA and control systems networks.

Craig Valli

2009-01-01

82

ETR BUILDING, TRA642, INTERIOR. BASEMENT. CUBICLE SHOWN IN ID33G101, ANOTHER ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ETR BUILDING, TRA-642, INTERIOR. BASEMENT. CUBICLE SHOWN IN ID-33-G-101, ANOTHER VIEW. PERSONNEL DOORWAY INTO CHAMBER IDENTIFIES SODIUM HAZARD AND POSSIBILITY OF INERT GAS. LIQUID SODIUM COOLANT WAS USED IN A SPECIAL ETR LOOP ADAPTED FOR IT IN 1972. INL NEGATIVE NO. HD24-3-2. Mike Crane, Photographer, 11/2000 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

83

Threshold extended ID3 algorithm  

NASA Astrophysics Data System (ADS)

Information exchange over insecure networks needs to provide authentication and confidentiality to the database in significant problem in datamining. In this paper we propose a novel authenticated multiparty ID3 Algorithm used to construct multiparty secret sharing decision tree for implementation in medical transactions.

Kumar, A. B. Rajesh; Ramesh, C. Phani; Madhusudhan, E.; Padmavathamma, M.

2012-04-01

84

ISS/IDS Detector Study  

SciTech Connect

This article summarises the results obtained by the detector working group of the 'International Scooping Study' (ISS) of a future neutrino oscillations facility. Special emphasis is put on far detectors, for which some of the main issues are identified. A detector R and D strategy in the context of the 'International Design Study' (IDS) for a neutrino factory is also presented.

Cervera-Villanueva, A. [Instituto de Fisica Corpuscular, C.S.I.C.-Universidad de Valencia (Spain)

2008-02-21

85

The International Doris Service (IDS)  

Microsoft Academic Search

The DORIS system was developed for precise orbit determination and precise positioning on Earth. In continuation of the DORIS Pilot Experiment initiated in 1999, the International DORIS Service (IDS) officially started on July 1, 2003 as an IAG Service after the decision of the IAG Executive Committee at the IUGG General Assembly in Sapporo. Following this decision, the IERS Directing

G. Tavernier; M. Feissel-Vernier; F. Lemoine; C. Noll; J. Ries; L. Soudarin; P. Willis

2004-01-01

86

Expression Pattern of Id Proteins in Medulloblastoma  

PubMed Central

Inhibitor of DNA binding or inhibitor of differentiation (Id) proteins are up regulated in a variety of neoplasms, particularly in association with high-grade, poorly differentiated tumors, while differentiated tissues show little or no Id expression. The four Id genes are members of the helix-loop-helix (HLH) family of transcription factors and act as negative regulators of transcription by binding to and sequestering HLH complexes. We tested the hypothesis that Id proteins are overexpressed in medulloblastoma by performing immunohistochemistry using a medulloblastoma tissue microarray with 45 unique medulloblastoma and 11 normal control cerebella, and antibodies specific for Id1, Id2, Id3, and Id4. A semi-quantitative staining score that took staining intensity and the proportion of immunoreactive cells into account was used. Id1 was not detected in normal cerebella or in medulloblastoma cells, but 78 % of tumors showed strong Id1 expression in endothelial nuclei of tumor vessels. Id2 expression was scant in normal cerebella and increased in medulloblastoma (median staining score: 4). Id3 expression was noted in some neurons of the developing cerebellar cortex, but it was markedly up regulated in medulloblastoma (median staining score: 12) and in tumor endothelial cells. Id4 was not expressed in normal cerebella or in tumor cells. Id2 or Id3 overexpression drove proliferation in medulloblastoma cell lines by altering the expression of critical cell cycle regulatory proteins in favor of cell proliferation. This study shows that Id1 expression in endothelial cells may contribute to angiogenic processes and that increased expression of Id2 and Id3 in medulloblastoma is potentially involved in tumor cell proliferation and survival.

Snyder, Andrew D.; Dulin-Smith, Ashley N.; Houston, Ronald H.; Durban, Ashley N.; Brisbin, Bethany J.; Oostra, Tyler D.; Marshall, Jordan T.; Kahwash, Basil M.

2013-01-01

87

Chipless ID for paper documents  

NASA Astrophysics Data System (ADS)

The notion of assigning every piece of paper that passes through a printer a unique ID encoded either on the surface or in the substrate of the page, regardless of its intended use or perceived importance, could prove to be a breakthrough of magnitude comparable to the now ubiquitous concept of referencing a webpage through the use of its Universal Resource Locater (URL). We see many opportunities for using chipless ID in the world of everyday documents, but also many challenges. In this paper, we begin to explore the ways this new technology can be used to enable advanced document management functions, along with its implications for the ways in which people use documents.

Lopresti, Daniel P.; Nagy, George

2004-12-01

88

IDS contribution to ITRF2008  

NASA Astrophysics Data System (ADS)

For the first time, the International DORIS Service (IDS) has produced a technique level combination based on the contributions of seven analysis centers (ACs), including the European Space Operations Center (ESOC), Geodetic Observatory Pecny (GOP), Geoscience Australia (GAU), the NASA Goddard Space Flight Center (GSFC), the Institut Géographique National (IGN), the Institute of Astronomy, Russian Academy of Sciences (INASAN, named as INA), and CNES/CLS (named as LCA). The ACs used five different software packages to process the DORIS data from 1992 to 2008, including NAPEOS (ESA), Bernese (GOP), GEODYN (GAU, GSC), GIPSY/OASIS (INA), and GINS (LCA). The data from seven DORIS satellites, TOPEX/Poseidon, SPOT-2, SPOT-3, SPOT-4, SPOT-5, Envisat and Jason-1 were processed and all the analysis centers produced weekly SINEX files in either variance-covariance or normal equation format. The processing by the analysis centers used the latest GRACE-derived gravity models, forward modelling of atmospheric gravity, updates to the radiation pressure modelling to improve the DORIS geocenter solutions, denser parameterization of empirically determined drag coefficients to improve station and EOP solutions, especially near the solar maximum in 2001-2002, updated troposphere mapping functions, and an ITRF2005-derived station set for orbit determination, DPOD2005. The CATREF software was used to process the weekly AC solutions, and produce three iterations of an IDS global weekly combination. Between the development of the initial solution IDS-1, and the final solution, IDS-3, the ACs improved their analysis strategies and submitted updated solutions to eliminate troposphere-derived biases in the solution scale, to reduce drag-related degradations in station positioning, and to refine the estimation strategy to improve the combination geocenter solution. An analysis of the frequency content of the individual AC geocenter and scale solutions was used as the basis to define the scale and geocenter of the IDS-3 combination. The final IDS-3 combination has an internal position consistency (WRMS) that is 15 to 20 mm before 2002 and 8 to 10 mm after 2002, when 4 or 5 satellites contribute to the weekly solutions. The final IDS-3 combination includes solutions for 130 DORIS stations on 67 different sites of which 35 have occupations over 16 years (1993.0-2009.0). The EOPs from the IDS-3 combination were compared with the IERS 05 C04 time series and the RMS agreement was 0.24 mas and 0.35 mas for the X and Y components of polar motion. The comparison to ITRF2005 in station position shows an agreement of 6 to 8 mm RMS in horizontal and 10.3 mm in height. The RMS comparison to ITRF2005 in station velocity is at 1.8 mm/year on the East component, to 1.2 mm/year in North component and 1.6 mm/year in height.

Valette, Jean-Jacques; Lemoine, Frank G.; Ferrage, Pascale; Yaya, Philippe; Altamimi, Zuheir; Willis, Pascal; Soudarin, Laurent

2010-12-01

89

IDS contribution to ITRF2013  

NASA Astrophysics Data System (ADS)

In the context of the forthcoming ITRF 2013, the IDS Combination Center is involved in the estimation of DORIS stations positions/velocities as well as Earth orientation parameters from DORIS data. These computations are based on the latest series of all of the 6 IDS Analysis Centers multi-satellite weekly SINEX solutions from January 1993 to December 2013. The primary objective of this study is to analyze the DORIS contribution to ITRF2013 in terms of (1) geocenter and scale solutions; (2) stations positions. Furthermore, we will focus on the impact of new standards such as the application of DORIS ground antennas phase laws in the data processing and improved modeling of DORIS ground beacon frequency variations. We will also address benefits of including new DORIS data in the IDS combination compared to ITRF2008, including data from new DORIS missions (e.g. Jason-2, Cryosat-2), as well as improved data for both Jason-1 and SPOT-5 where these satellite data are now corrected to accommodate perturbations introduced by the South Atlantic Anomaly (SAA). In addition we will compare this new DORIS ITRF realization to the previous realization (ITRF2008).

Moreaux, Guilhem; Lemoine, Frank; Willis, Pascal; Capdeville, Hugues; Otten, Michiel; Stepanek, Petr; Kuzin, Sergei; Ferrage, Pascale

2014-05-01

90

118. COTTONWOOD CREEK SPILL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

118. COTTONWOOD CREEK SPILL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; WEST VIEW OF GATES ON HIGH LINE CANAL. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

91

129. COTTONWOOD CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

129. COTTONWOOD CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; OUTLET SIDE OF SIPHON UNDER CANAL. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

92

141. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

141. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER, IDAHO; CLOSE-UP OF MAIN HEADGATES, RADIAL GATES INSIDE, SOUTHEAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

93

97. POINT SPILL, TWIN FALLS MAIN CANAL, TWIN FALLS COUNTY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

97. POINT SPILL, TWIN FALLS MAIN CANAL, TWIN FALLS COUNTY NORTHWEST OF MURTAUGH, IDAHO; OVERALL WEST VIEW FROM CANAL SIDE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

94

90. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

90. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH OF FILER, IDAHO; CLOSE-UP OF GATES. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

95

99. POINT SPILL, TWIN FALLS MAIN CANAL, TWIN FALLS COUNTY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

99. POINT SPILL, TWIN FALLS MAIN CANAL, TWIN FALLS COUNTY NORTHWEST OF MURTAUGH, IDAHO; CLOSE-UP OF OUTLET SIDE OF GATES, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

96

110. ROCK CREEK SIPHON, LOW LINE CANAL, TWIN FALLS COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

110. ROCK CREEK SIPHON, LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; INLET SIDE WEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

97

93. ROCK CREEK SIPHON, LOW LINE CANAL, TWIN FALLS COUNTY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

93. ROCK CREEK SIPHON, LOW LINE CANAL, TWIN FALLS COUNTY SOUTH OF KIMBERLY, IDAHO; OVERALL NORTHEAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

98

113. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

113. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY IDAHO; CLOSE-UP OF INLET SIDE OF SIPHON, NORTHWEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

99

115. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

115. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY IDAHO; WEST VIEW OF SIPHON CROSSING ROCK CREEK. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

100

104. DRY CREEK OUTLET (SPILL), TWIN FALLS COUNTY, SOUTH OF ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

104. DRY CREEK OUTLET (SPILL), TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; OUTLET FOR MURTAUGH LAKE, SOUTHEAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

101

103. DRY CREEK SPILL, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

103. DRY CREEK SPILL, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; INLET SIDE TO DRY CREEK, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

102

98. SHOESTRING, TWIN FALLS MAIN CANAL, TWIN FALLS COUNTY NORTHWEST ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

98. SHOESTRING, TWIN FALLS MAIN CANAL, TWIN FALLS COUNTY NORTHWEST OF MURTAUGH, IDAHO; PROFILE VIEW, SOUTH. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

103

109. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

109. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF FILER, IDAHO; OVERALL VIEW LOOKING WEST. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

104

94. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

94. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY SOUTH OF FILER, IDAHO; CLOSE-UP OF GATES FROM THE CANAL SIDE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

105

91. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

91. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH OF FILER, IDAHO; NORTHEAST VIEW OF CANAL AND GATES. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

106

121. MCMULLEN CREEK DRAW, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

121. MCMULLEN CREEK DRAW, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; OUTLET SIDE OF CREEK, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

107

122. MCMULLEN CREEK, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

122. MCMULLEN CREEK, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; INLET SIDE OF THE CREEK, ENTRANCE INTO THE HIGH LINE CANAL, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

108

89. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

89. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH OF FILER, IDAHO; OUTLET SIDE OF CANAL, SOUTHWEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

109

101. DRY CREEK SPILL, MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

101. DRY CREEK SPILL, MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; NORTHEAST VIEW OF DRY CREEK OUTLET. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

110

148. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

148. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER DAM; HEADGATES AT INLET, SOUTHWEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

111

114. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

114. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY IDAHO; OVERALL VIEW, WEST OF INLET SIDE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

112

106. DRY CREEK SPILL, MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

106. DRY CREEK SPILL, MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; CLOSE-UP OF GATES, NORTHWEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

113

147. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

147. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER, IDAHO; VIEW OF MAIN HEADGATES, EAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

114

117. COTTONWOOD CREEK SPILL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

117. COTTONWOOD CREEK SPILL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; CLOSE-UP OF OUTLET SIDE OF SPILL, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

115

126. COTTONWOOD CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

126. COTTONWOOD CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; CLOSE-UP OF OUTLET SIDE OF SIPHON, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

116

119. COTTONWOOD CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

119. COTTONWOOD CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; INLET SIDE OF COTTONWOOD CREEK, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

117

149. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

149. TWIN FALLS MAIN CANAL DIVERSION, TWIN FALLS COUNTY, MILNER DAM; CLOSE-UP OF MAIN CANAL GATES, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

118

116. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

116. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY IDAHO; CLOSE-UP OF OUTLET, DIVERSION SPILL IN BACKGROUND, WEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

119

112. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

112. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY IDAHO; OUTLET SIDE, EAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

120

88. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

88. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH OF FILER, IDAHO; WEST VIEW OF CANAL AND GATES. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

121

105. MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

105. MURTAUGH LAKE, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; NORTHWEST VIEW OF LAKE AND HEADGATES. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

122

111. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

111. ROCK CREEK SIPHON LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY IDAHO; OVERALL VIEW OF SIPHON, EAST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

123

95. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

95. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY SOUTH OF FILER, IDAHO; OVERALL VIEW LOOKING EAST. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

124

124. MCMULLEN CREEK HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

124. MCMULLEN CREEK HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; OVERALL SOUTH VIEW OF DRAW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

125

120. COTTONWOOD CUT AREA, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

120. COTTONWOOD CUT AREA, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; OVERALL VIEW OF THE COTTONWOOD CREEK DRAW, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

126

92. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

92. CEDAR DRAW SPILL, HIGH LINE CANAL, TWIN FALLS COUNTY SOUTH OF FILER, IDAHO; CLOSE-UP OF OUTLET SIDE OF GATES, SOUTH VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

127

96. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

96. CEDAR DRAW SPILL, LOW LINE CANAL, TWIN FALLS COUNTY SOUTH OF FILER, IDAHO; OUTLET SIDE OF CEDAR DRAW, WEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

128

102. MURTAUGH LAKE HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

102. MURTAUGH LAKE HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; LAKE SIDE OF HEADGATES, NORTHWEST VIEW. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

129

123. MCMULLEN CREEK, HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

123. MCMULLEN CREEK, HIGH LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; SOUTH VIEW OF THE CREEK EMPTYING INTO THE HIGH LINE CANAL. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

130

Metal and Nonmetal Mine Safety and Health Report on Investigation: Surface Nonmetal Mine (Cement). Fatal Powered Haulage Accident, May 28, 2012, Lehigh Northeast Cement Company, Glens Falls Plant, Glens Falls, Warren County, New York. I.D. No. 30-00585.  

National Technical Information Service (NTIS)

Glens Falls Plant, a cement plant owned and operated by Lehigh Northeast Cement Company, is located in Glens Falls, Warren County, New York. Christoph Striecher, Vice-President of Operations, and Stuart Guinther, Plant Manager, are the principal operating...

2012-01-01

131

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease.  

PubMed

Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We found that T cell antigen receptor (TCR)-driven signaling initially decreased the abundance of Id3, which led to the activation of a follicular regulatory T (TFR) cell-specific transcription signature. However, sustained lower abundance of Id2 and Id3 interfered with proper development of TFR cells. Depletion of Id2 and Id3 expression in Treg cells resulted in compromised maintenance and localization of the Treg cell population. Thus, Id2 and Id3 enforce TFR cell checkpoints and control the maintenance and homing of Treg cells. PMID:24973820

Miyazaki, Masaki; Miyazaki, Kazuko; Chen, Shuwen; Itoi, Manami; Miller, Marina; Lu, Li-Fan; Varki, Nissi; Chang, Aaron N; Broide, David H; Murre, Cornelis

2014-08-01

132

Coal Mine Safety and Health Report of Investigation: Surface Mine Facility. Slip and Fall Accident, March 9, 2008, Resulting Death April 4, 2008, Chargeable as of November 24, 2008. Warrior Preparation Plant, Warrior Coal, LLC, Madisonville, Hopkins County, KY, ID No. 15-14335.  

National Technical Information Service (NTIS)

On Sunday, March 9, 2008, five miners were scheduled to perform train load-out duty at the Warrior Coal, LLC, Warrior Preparation Plant, MSHA ID, 15-14335. At approximately 6:30 a.m., Michael H. Rickard, laborer, was injured as he walked outside the wareh...

W. Barnwell

2008-01-01

133

ID-based secret-key cryptography  

Microsoft Academic Search

This paper introduces ID-based secret-key cryptography, in which secret keys are privately and uniquely binded to an identity. This enables to extend public-key cryptography features at the high throughput rate of secret-key cryptography. As applications, efficient login protocols, an enhanced version of Kerberos, and an ID-based MAC algorithm are presented.ID-based systems were initially developed in the context of public-key cryptography

Marc Joye; Sung-Ming Yen

1998-01-01

134

Id1 and Id3 expression is associated with increasing grade of prostate cancer: Id3 preferentially regulates CDKN1B  

PubMed Central

As transcriptional regulators of basic helix–oop–helix (bHLH) transcription and non-bHLH factors, the inhibitor of differentiation (Id1, Id2, Id3, and Id4) proteins play a critical role in coordinated regulation of cell growth, differentiation, tumorigenesis, and angiogenesis. Id1 regulates prostate cancer (PCa) cell proliferation, apoptosis, and androgen independence, but its clinical significance in PCa remains controversial. Moreover, there is lack of evidence on the expression of Id2 and Id3 in PCa progression. In this study we investigated the expression of Id2 and Id3 and reevaluated the expression of Id1 in PCa. We show that increased Id1 and Id3 protein expression is strongly associated with increasing grade of PCa. At the molecular level, we report that silencing either Id1 or Id3 attenuates cell cycle. Although structurally and mechanistically similar, our results show that both these proteins are noncompensatory at least in PCa progression. Moreover, through gene silencing approaches we show that Id1 and Id3 primarily attenuates CDKN1A (p21) and CDKN1B (p27), respectively. We also demonstrate that silencing Id3 alone significantly attenuates proliferation of PCa cells as compared with Id1. We propose that increased Id1 and Id3 expression attenuates all three cyclin-dependent kinase inhibitors (CDKN2B, -1A, and -1B) resulting in a more aggressive PCa phenotype.

Sharma, Pankaj; Patel, Divya; Chaudhary, Jaideep

2012-01-01

135

Health assessment for Bunker Hill Mining and Metallurgical Complex, Kellogg, Shoshone County, Idaho, Region 10. CERCLIS No. IDD048340921. Addenda. Preliminary report  

SciTech Connect

The Bunker Hill site is listed, by the U.S. Environmental Protection Agency (EPA), on the National Priorities List (NPL). The 21 square-mile site includes the Bunker Hill mining and smelting complexes and the communities of Pinehurst, Page, Smelterville, Kellog, and Wardner, Idaho. Mining and smelting operations have occurred in the area (Silver Valley) since the 1880's. The Bunker Hill smelter discontinued operation in 1982. The former milling and smelting operation at the Bunker Hill Complex has left behind contaminated soils and deposits of slag, mine tailings, and other process residuals. Based upon the information reviewed, ATSDR has concluded that this site is of public health concern because of the risk to human health caused by the probable human exposure to hazardous substances at concentrations that may result in adverse health effects. Human exposure to heavy metals is probably occurring via ingestion, dermal, or inhalation exposure to contaminated surface soils, mine wastes and tailings, surface waters, or contaminated foodstuffs.

Not Available

1989-10-10

136

Programmable reflectors for SAW-ID-tags  

Microsoft Academic Search

Surface acoustic wave devices for identification systems (SAW-ID-tags or SAW wireless labels) have a large potential for future applications. We concentrate in this paper on reflective SAW-ID-tags with amplitude modulation. We use splitfinger interdigital transducers as reflecting structures. If the transducers are short circuited or capacitively loaded the reflection disappears almost entirely. On the other hand, if an open circuit

L. Reindl; W. Ruile

1993-01-01

137

2. PHOSPHATE UNLOADING BUILDING. VIEW IS TO THE NORTH. THIS ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. PHOSPHATE UNLOADING BUILDING. VIEW IS TO THE NORTH. THIS STRUCTURE WAS RELOCATED TO THE SOUTH OF ITS ORIGINAL SITE IN 1993 FOR USE AS A DECONTAMINATION FACILITY WITHIN THE BUNKER HILL SUPERFUND SITE. - North Idaho Phosphate Company, Silver King Community, Kellogg, Shoshone County, ID

138

AFRD WAREHOUSE, WEST SIDE DETAIL OF ALTERED SLIDING DOORS, FACING ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

AFRD WAREHOUSE, WEST SIDE DETAIL OF ALTERED SLIDING DOORS, FACING EAST. WEATHER COVER OVER RAIL IS ORIGINAL. SHEET METAL SIDING HAS BEEN INSERTED BETWEEN TWO HALVES OF SLIDING DOORS. - Minidoka Relocation Center Warehouse, 111 South Fir Street, Shoshone, Lincoln County, ID

139

AFRD WAREHOUSE, EAST SIDE DETAIL SHOWS CONNECTION OF LEANTO TO ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

AFRD WAREHOUSE, EAST SIDE DETAIL SHOWS CONNECTION OF LEAN-TO TO WALL. FACING WEST. NOTE THE PROFILE OF THE METAL AWNING ON SOUTH SIDE. ELECTRICAL CONDUIT AND OTHER SERVICES PENETRATE WALL. POLE SECURED WITH TRIANGULAR BRACES AT CORNER IS COMMUNICATION POLE. - Minidoka Relocation Center Warehouse, 111 South Fir Street, Shoshone, Lincoln County, ID

140

2. BUNKER HILL LEAD SMELTER. VIEW IS FROM CIA TO ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. BUNKER HILL LEAD SMELTER. VIEW IS FROM CIA TO THE SOUTH. IN FOREGROUND, PLANT DRY, SLAG FUMING PLANT, BLAST FURNACE, SMELTER OFFICE, LEAD AND SILVER REFINERIES ARE VISIBLE, L. TO R. HIGH VELOCITY FLUE LEADS FROM LOWER PLANT TO BAG HOUSE AND STACKS AT TOP OF SMELTING FACILITY. - Bunker Hill Lead Smelter, Bradley Rail Siding, Kellogg, Shoshone County, ID

141

Id: A Target of BMP Signaling  

NSDL National Science Digital Library

Cytokines of the transforming growth factor-β (TGF-β) superfamily transduce their signals by activating receptor-regulated Smads (R-Smads). Distinct R-Smads or combinations of R-Smads are activated by TGF-β, activin, or bone morphogenetic proteins (BMPs). R-Smads activated by BMPs induce expression of Id proteins, which act as inhibitors of differentiation and stimulators of cell growth by inhibiting the function of basic helix-loop-helix transcription factors. In endothelial cells, TGF-β binds to two distinct type I receptor serine-threonine kinases, ALK-5 and ALK-1; the latter activates the same R-Smads that are activated by BMP and induces synthesis of Id (inhibitor of differentation or inhibitor of DNA binding) proteins. Growing evidence suggests that Id proteins may play crucial roles in angiogenesis, neurogenesis, and osteogenesis and act as key molecules in regulating biological responses induced by BMPs and TGF-β.

Kohei Miyazono (University of Tokyo;Department of Molecular Pathology, Graduate School of Medicine REV); Keiji Miyazawa (University of Tokyo;Department of Molecular Pathology, Graduate School of Medicine REV)

2002-09-24

142

Estimation of unsaturated zone traveltimes for Rainier Mesa and Shoshone Mountain, Nevada Test Site, Nevada, using a source-responsive preferential-flow model  

SciTech Connect

Traveltimes for contaminant transport by water from a point in the unsaturated zone to the saturated zone are a concern at Rainier Mesa and Shoshone Mountain in the Nevada Test Site, Nevada. Where nuclear tests were conducted in the unsaturated zone, contaminants must traverse hundreds of meters of variably saturated rock before they enter the saturated zone in the carbonate rock, where the regional groundwater system has the potential to carry them substantial distances to a location of concern. The unsaturated-zone portion of the contaminant transport path may cause a significant delay, in addition to the time required to travel within the saturated zone, and thus may be important in the overall evaluation of the potential hazard from contamination. Downward contaminant transport through the unsaturated zone occurs through various processes and pathways; this can lead to a broad distribution of contaminant traveltimes, including exceedingly slow and unexpectedly fast extremes. Though the bulk of mobile contaminant arrives between the time-scale end members, the fastest contaminant transport speed, in other words the speed determined by the combination of possible processes and pathways that would bring a measureable quantity of contaminant to the aquifer in the shortest time, carries particular regulatory significance because of its relevance in formulating the most conservative hazard-prevention scenarios. Unsaturated-zone flow is usually modeled as a diffusive process responding to gravity and pressure gradients as mediated by the unsaturated hydraulic properties of the materials traversed. The mathematical formulation of the diffuse-flow concept is known as Richards' equation, which when coupled to a solute transport equation, such as the advection-dispersion equation, provides a framework to simulate contaminant migration in the unsaturated zone. In recent decades awareness has increased that much fluid flow and contaminant transport within the unsaturated zone takes place as preferential flow, faster than would be predicted by the coupled Richards' and advection-dispersion equations with hydraulic properties estimated by traditional means. At present the hydrologic community has not achieved consensus as to whether a modification of Richards' equation, or a fundamentally different formulation, would best quantify preferential flow. Where the fastest contaminant transport speed is what needs to be estimated, there is the possibility of simplification of the evaluation process. One way of doing so is by a two-step process in which the first step is to evaluate whether significant preferential flow and solute transport is possible for the media and conditions of concern. The second step is to carry out (a) a basic Richards' and advection-dispersion equation analysis if it is concluded that preferential flow is not possible or (b) an analysis that considers only the fastest possible preferential-flow processes, if preferential flow is possible. For the preferential-flow situation, a recently published model describable as a Source-Responsive Preferential-Flow (SRPF) model is an easily applied option. This report documents the application of this two-step process to flow through the thick unsaturated zones of Rainier Mesa and Shoshone Mountain in the Nevada Test Site. Application of the SRPF model involves distinguishing between continuous and intermittent water supply to preferential flow paths. At Rainier Mesa and Shoshone Mountain this issue is complicated by the fact that contaminant travel begins at a location deep in the subsurface, where there may be perched water that may or may not act like a continuous supply, depending on such features as the connectedness of fractures and the nature of impeding layers. We have treated this situation by hypothesizing both continuous and intermittent scenarios for contaminant transport to the carbonate aquifer and reporting estimation of the fastest speed for both of these end members.

Brian A. Ebel; John R. Nimmo

2009-09-11

143

Estimation of Unsaturated Zone Traveltimes for Rainier Mesa and Shoshone Mountain, Nevada Test Site, Nevada, Using a Source-Responsive Preferential-Flow Model  

USGS Publications Warehouse

Traveltimes for contaminant transport by water from a point in the unsaturated zone to the saturated zone are a concern at Rainier Mesa and Shoshone Mountain in the Nevada Test Site, Nevada. Where nuclear tests were conducted in the unsaturated zone, contaminants must traverse hundreds of meters of variably saturated rock before they enter the saturated zone in the carbonate rock, where the regional groundwater system has the potential to carry them substantial distances to a location of concern. The unsaturated-zone portion of the contaminant transport path may cause a significant delay, in addition to the time required to travel within the saturated zone, and thus may be important in the overall evaluation of the potential hazard from contamination. Downward contaminant transport through the unsaturated zone occurs through various processes and pathways; this can lead to a broad distribution of contaminant traveltimes, including exceedingly slow and unexpectedly fast extremes. Though the bulk of mobile contaminant arrives between the time-scale end members, the fastest contaminant transport speed, in other words the speed determined by the combination of possible processes and pathways that would bring a measureable quantity of contaminant to the aquifer in the shortest time, carries particular regulatory significance because of its relevance in formulating the most conservative hazard-prevention scenarios. Unsaturated-zone flow is usually modeled as a diffusive process responding to gravity and pressure gradients as mediated by the unsaturated hydraulic properties of the materials traversed. The mathematical formulation of the diffuse-flow concept is known as Richards' equation, which when coupled to a solute transport equation, such as the advection-dispersion equation, provides a framework to simulate contaminant migration in the unsaturated zone. In recent decades awareness has increased that much fluid flow and contaminant transport within the unsaturated zone takes place as preferential flow, faster than would be predicted by the coupled Richards' and advection-dispersion equations with hydraulic properties estimated by traditional means. At present the hydrologic community has not achieved consensus as to whether a modification of Richards' equation, or a fundamentally different formulation, would best quantify preferential flow. Where the fastest contaminant transport speed is what needs to be estimated, there is the possibility of simplification of the evaluation process. One way of doing so is by a two-step process in which the first step is to evaluate whether significant preferential flow and solute transport is possible for the media and conditions of concern. The second step is to carry out (a) a basic Richards' and advection-dispersion equation analysis if it is concluded that preferential flow is not possible or (b) an analysis that considers only the fastest possible preferential-flow processes, if preferential flow is possible. For the preferential-flow situation, a recently published model describable as a Source-Responsive Preferential-Flow (SRPF) model is an easily applied option. This report documents the application of this two-step process to flow through the thick unsaturated zones of Rainier Mesa and Shoshone Mountain in the Nevada Test Site. Application of the SRPF model involves distinguishing between continuous and intermittent water supply to preferential flow paths. At Rainier Mesa and Shoshone Mountain this issue is complicated by the fact that contaminant travel begins at a location deep in the subsurface, where there may be perched water that may or may not act like a continuous supply, depending on such features as the connectedness of fractures and the nature of impeding layers. We have treated this situation by hypothesizing both continuous and intermittent scenarios for contaminant transport to the carbonate aquifer and reporting estimation of the fastest speed for both of th

Ebel, Brian A.; Nimmo, John R.

2009-01-01

144

A general purpose application layer IDS  

Microsoft Academic Search

This article concentrates on the design and implementation of a general purpose application layer IDS (intrusion detection system). Being different from the traditional IDSs based on the network layer, this system can rebuild the TCP sessions and deal with different kinds of intrusions on the application layer. The whole process can be described briefly as: The system reassembles the IP

Shishi Liu; Jizhou Sun; Xiaoling Zhao; Zunce Wei

2003-01-01

145

What Is "Real-World" ID Anyway?  

ERIC Educational Resources Information Center

The term "real-world ID" is commonly heard at professional conferences, but its meaning is assumed rather than defined. Unless we examine the meanings and implications of rhetoric of the field, we risk error in presenting ourselves, and we risk derailing the progress of our profession. This article examines the term "real world" as applied to…

Hardre, Patricia L.

2013-01-01

146

Role of ID Proteins in Breast Cancer.  

National Technical Information Service (NTIS)

The basic helix-loop-helix transcription factors, E12 and E47 (products of the E2A gene), have been implicated to have a role as tumor suppressors. Conversely, the inhibitors of El2 and E47, the Id proteins, have been shown to stimulate cell growth, and c...

X. Sun

1999-01-01

147

BOISE RIVER STUDY IN ADA COUNTY IDAHO, 1978  

EPA Science Inventory

The purpose of this study was to assess the impact of present point sources on the river and to obtain background information to develop effluent limitations for the City of Boise wastewater treatment facilities. The study was conducted on the Boise River (Ada County, ID) from L...

148

Percent Uninsured by County  

NSDL National Science Digital Library

This is a county by county visualization of the percentage of residents that are uninsured. The data are from a set available here: http://manyeyes.alphaworks.ibm.com/manyeyes/datasets/percent-uninsured-by-county/versions/1

Manyeyes

149

Id-1 and Id-2 Are Overexpressed in Pancreatic Cancer and in Dysplastic Lesions in Chronic Pancreatitis  

PubMed Central

Id proteins antagonize basic helix-loop-helix proteins, inhibit differentiation, and enhance cell proliferation. In this study we compared the expression of Id-1, Id-2, and Id-3 in the normal pancreas, in pancreatic cancer, and in chronic pancreatitis (CP). Northern blot analysis demonstrated that all three Id mRNA species were expressed at high levels in pancreatic cancer samples by comparison with normal or CP samples. Pancreatic cancer cell lines frequently coexpressed all three Ids, exhibiting a good correlation between Id mRNA and protein levels, as determined by immunoblotting with highly specific anti-Id antibodies. Immunohistochemistry using these antibodies demonstrated the presence of faint Id-1 and Id-2 immunostaining in pancreatic ductal cells in the normal pancreas, whereas Id-3 immunoreactivity ranged from weak to strong. In the cancer tissues, many of the cancer cells exhibited abundant Id-1, Id-2, and Id-3 immunoreactivity. Scoring on the basis of percentage of positive cells and intensity of immunostaining indicated that Id-1 and Id-2 were increased significantly in the cancer cells by comparison with the respective controls. Mild to moderate Id immunoreactivity was also seen in the ductal cells in the CP-like areas adjacent to these cells and in the ductal cells of small and interlobular ducts in CP. In contrast, in dysplastic and atypical papillary ducts in CP, Id-1 and Id-2 immunoreactivity was as significantly elevated as in the cancer cells. These findings suggest that increased Id expression may be associated with enhanced proliferative potential of pancreatic cancer cells and of proliferating or dysplastic ductal cells in CP.

Maruyama, Haruhisa; Kleeff, Jorg; Wildi, Stefan; Friess, Helmut; Buchler, Markus W.; Israel, Mark A.; Korc, Murray

1999-01-01

150

DRAFT LANDSAT DATA MOSAIC: MONTGOMERY COUNTY, TEXAS; HARRIS COUNTY, TEXAS; FORT BEND COUNTY, TEXAS; BRAZORIA COUNTY, TEXAS; GALVESTON COUNTY, TEXAS  

EPA Science Inventory

This is a draft Landsat Data Mosaic, which contains remote sensing information for Montgomery County, Texas Harris County, Texas Fort Bend County, Texas Brazoria County, Texas Galveston County, and Texas Imagery dates on the following dates: October 6, 1999 and September 29, 200...

151

78 FR 65555 - Establishment of Class E Airspace; Salmon, ID  

Federal Register 2010, 2011, 2012, 2013

...Establishment of Class E Airspace; Salmon, ID AGENCY: Federal Aviation Administration...action establishes Class E airspace at the Salmon VHF Omni-Directional Radio Range/Distance...Equipment (VOR/DME) navigation aid, Salmon, ID, to facilitate vectoring of...

2013-11-01

152

Geologic Surface Effects of Underground Nuclear Testing, Buckboard Mesa, Climax Stock, Dome Mountain, Frenchman Flat, Rainier/Aqueduct Mesa, and Shoshone Mountain, Nevada Test Site, Nevada  

USGS Publications Warehouse

Surface effects maps were produced for 72 of 89 underground detonations conducted at the Frenchman Flat, Rainier Mesa and Aqueduct Mesa, Climax Stock, Shoshone Mountain, Buckboard Mesa, and Dome Mountain testing areas of the Nevada Test Site between August 10, 1957 (Saturn detonation, Area 12) and September 18, 1992 (Hunters Trophy detonation, Area 12). The ?Other Areas? Surface Effects Map Database, which was used to construct the maps shown in this report, contains digital reproductions of these original maps. The database is provided in both ArcGIS (v. 8.2) geodatabase format and ArcView (v. 3.2) shapefile format. This database contains sinks, cracks, faults, and other surface effects having a combined (cumulative) length of 136.38 km (84.74 mi). In GIS digital format, the user can view all surface effects maps simultaneously, select and view the surface effects of one or more sites of interest, or view specific surface effects by area or site. Three map layers comprise the database. They are: (1) the surface effects maps layer (oase_n27f), (2) the bar symbols layer (oase_bar_n27f), and (3) the ball symbols layer (oase_ball_n27f). Additionally, an annotation layer, named 'Ball_and_Bar_Labels,' and a polygon features layer, named 'Area12_features_poly_n27f,' are contained in the geodatabase version of the database. The annotation layer automatically labels all 295 ball-and-bar symbols shown on these maps. The polygon features layer displays areas of ground disturbances, such as rock spall and disturbed ground caused by the detonations. Shapefile versions of the polygon features layer in Nevada State Plane and Universal Transverse Mercator projections, named 'area12_features_poly_n27f.shp' and 'area12_features_poly_u83m.shp,' are also provided in the archive.

Grasso, Dennis N.

2003-01-01

153

Id1 Delays Senescence of Primary Human Melanocytes  

PubMed Central

The Id family of helix-loop-helix transcription factors is upregulated in a variety of human malignancies and has been implicated in promoting tumorigenesis through effects on cell growth, differentiation, and tumor angiogenesis. While expression of Id proteins has been associated with tumorigenesis, the precise mechanistic relationship between Id expression and carcinogenesis has not been clearly delineated. We have previously shown that Id1 delays cellular senescence in primary mammalian cells through inhibition of the cell cycle regulatory protein and familial melanoma gene, p16/INK4a. We have also demonstrated that Id1 expression is upregulated in early stage primary human melanomas and may be an important marker for early malignancy. In order to further define the role of Id1 in human melanoma development, we have evaluated the function of Id1 in primary human melanocytes. Here we show that constitutive expression of Id1 in primary human melanocytes leads to delayed cellular senescence and decreased expression of the familial melanoma gene, p16/INK4a. Although melanocytes constitutively expressing Id1 are shown to possess extended lifespans, this is not associated with an appreciable change in cell growth or telomere length. We conclude that Id1 delays cellular senescence in primary human melanocytes through inhibition of p16/INK4a expression and suggest that Id1 may contribute to the malignant conversion of primary human melanocytes through extension of cellular lifespan.

Cummings, Staci D.; Ryu, Byungwoo; Samuels, Michael A.; Yu, Xiaobing; Meeker, Alan K.; Healey, Megan A.; Alani, Rhoda M.

2014-01-01

154

Id transcriptional regulators in adipogenesis and adipose tissue metabolism.  

PubMed

Id proteins (Id1-Id4) are helix-loop-helix (HLH) transcriptional regulators that lack a basic DNA binding domain. They act as negative regulators of basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibit their DNA binding and transcriptional activity. Id proteins areimplicated in the regulation of various cellular mechanisms such as cell proliferation, cellular differentiation, cell fate determination, angiogenesis and tumorigenesis. A handful of recent studies also disclosed that Id proteins have critical functions in adipocyte differentiation and adipose tissue metabolism. Here, we reviewed the progress made thus far in understanding the specific functions of Id proteins in adipose tissue differentiation and metabolism. In addition to reviewing the known mechanisms of action, we also discuss possible additional mechanisms in which Id proteins might participate in regulating adipogenic and metabolic pathways. PMID:24896358

Patil, Mallikarjun; Sharma, Bal Krishan; Satyanarayana, Ande

2014-01-01

155

Percent Uninsured by County  

NSDL National Science Digital Library

This is a county by county visualization of the percentage of residents that are uninsured. The data are from a set available here: http://www-958.ibm.com/software/data/cognos/manyeyes/datasets/percent-uninsured-by-county/versions/1

Manyeyes

156

Reviewing County Extension Programs  

ERIC Educational Resources Information Center

A review of the effectiveness of extension education programs in Douglas County, Kansas is presented. Data were collected through a review of program data, interviews, and questionnaires sent to county residents. The results indicate a general knowledge and acceptance of the county's extension services among the respondents. (EC)

Prawl, Warren L.; Jorns, William J.

1976-01-01

157

Expression and functional role of the Id HLH family in cultured astrocytes  

Microsoft Academic Search

The Id family of helix-loop-helix factors (Id1, Id2, and Id3) expressed in many types of cells has been reported to negatively regulate myoblast differentiation and is required for G1\\/S progression of arrested fibroblasts. Our previous studies have indicated that Id1, Id2, and Id3 mRNA expression appear in the subventricular zone of 1-day-old rat brains. At later ages, Id3 mRNA was

Shun-Fen Tzeng; Jean de Vellis

1997-01-01

158

Uncertain reasoning in an ID3 machine learning framework  

Microsoft Academic Search

Quinlan's ID3 is a symbolic machine learning algorithm which uses training examples as input and constructs a decision tree as output. One problem with the standard decision tree approach to machine learning is that uncertain data, either in training and\\/or testing, often produces poor classification accuracies. The UR-ID3 algorithm described combines uncertain reasoning with the rule set produced by ID3

Peter E. Maher; D. St. Clair

1993-01-01

159

BioID: A Multimodal Biometric Identification System  

Microsoft Academic Search

accurate identification.BioID is the first identification system we know of thatuses a dynamic feature, lip movement.1This featuremakes BioID more secure against fraud than systemsusing only static features such as fingerprints.Commercially available since 1998, the system hasdemonstrated its reliability in many installationsaround the world.SYSTEM FUNCTIONSFigure 1 diagrams BioID's functions. The systemacquires (records), preprocesses, and classifies eachbiometric feature...

Robert Frischholz; Ulrich Dieckmann

2000-01-01

160

ID4: a new player in the cancer arena  

PubMed Central

Id proteins (Id-1 to 4) are dominant negative regulators of basic helix-loop-helix transcription factors. They play a key role during development, preventing cell differentiation while inducing cell proliferation. They are poorly expressed in adult life but can be reactivated in tumorigenesis. Several evidences indicate that Id proteins are associated with loss of differentiation, unrestricted proliferation and neoangiogenesis in diverse human cancers. Recently, we identified Id4 as a transcriptional target of the protein complex mutant p53/E2F1/p300 in breast cancer. Id4 protein binds, stabilizes and enhances the translation of mRNAs encoding proangiogenic cytokines, such as IL8 and GRO-alpha, increasing the angiogenic potential of cancer cells. We present here an overview of the current experimental data that links Id4 to cancer. We provide evidence also of the induction of Id4 following anticancer treatments in mutant p53-carrying cells. Indeed, mutant p53 is recruited to a specific region of the Id4 promoter upon DNA damage. Our findings indicate that Id4, besides its proangiogenic role, might also participate in the chemoresistance associated to mutant p53 proteins exerting gain of function activities.

Dell'Orso, Stefania; Ganci, Federica; Strano, Sabrina; Blandino, Giovanni; Fontemaggi, Giulia

2010-01-01

161

77 FR 13072 - Salmon-Challis National Forest, Butte, Custer and Lemhi Counties, ID, Supplemental Environmental...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Salmon-Challis National Forest, Butte, Custer...Environmental Impact Statement to the 2009 Salmon- Challis National Forest Travel Planning...SUMMARY: The Salmon-Challis National Forest announces...

2012-03-05

162

75 FR 71143 - Notice of Realty Action: Direct Sale of Public Land in Blaine County, ID  

Federal Register 2010, 2011, 2012, 2013

...and educational center. The Animal Shelter owns approximately 5...the proposed sale parcel. The Animal Shelter was issued a right-of-way for a road and a fence...the last 20 years or so, the Animal Shelter has inadvertently...

2010-11-22

163

Health Consultation: Sunoco Refinery, City of Oregon, Lucas County, Ohio. EPA Facility ID: OHD005046511.  

National Technical Information Service (NTIS)

The Agency for Toxic Substances and Disease Registry (ATSDR) was petitioned by a resident of Oregon, Ohio to assess the potential health impact on area residents from exposure to air emissions from the Sunoco Refinery (Sun). The Sunoco Refinery is located...

2005-01-01

164

75 FR 10811 - Notice of Application for Recordable Disclaimer of Interest in Lands, Gem County, ID  

Federal Register 2010, 2011, 2012, 2013

...Interest for a portion of two islands in the Payette River described as follows: A parcel of...beginning of line L1 on the bank of the Payette River, thence, with meanders along the bank of the Payette River. S....

2010-03-09

165

78 FR 23952 - Notice of Temporary Closure on Public Lands in Elmore County, ID  

Federal Register 2010, 2011, 2012, 2013

...pasture boundary fence burned in the fire will be repaired to restrict livestock...the following rule within the Stout Fire closure: Motorized vehicles must...members of organized rescue or fire-fighting forces in the performance of...

2013-04-23

166

CONWAY GULCH, CANYON COUNTY, ID STATE AGRICULTURAL WATER QUALITY PROGRAM, 1988-1989  

EPA Science Inventory

The Conway Gulch area (17050114) is a major source of pollutants effecting water quality and beneficial uses in Conway Gulch and the Lower Boise River. A pollution source and transport monitoring technique was used in evaluating water quality. The objective of this monitoring e...

167

77 FR 64352 - Notice of Temporary Closure of Public Lands in Custer County, ID  

Federal Register 2010, 2011, 2012, 2013

...other variable conditions. The closure will last only as long as the gather. FOR FURTHER INFORMATION CONTACT: Todd...personnel to a designated public observation area as long as they stay in that observation area. Penalties: In...

2012-10-19

168

Health Consultation: Michigan Industrial Finishes Corporation, Hamtramck, Wayne County, Michigan. EPA Facility ID: MIN000509131.  

National Technical Information Service (NTIS)

The Michigan Department of Environmental Quality (DEQ) asked for the assistance of the Michigan Department of Community Health (DCH) to identify the public health hazards present at the Michigan Industrial Finishes Corporation (MIF) facility in Hamtramck,...

2005-01-01

169

75 FR 57053 - Camas National Wildlife Refuge, Jefferson County, ID; Comprehensive Conservation Plan and...  

Federal Register 2010, 2011, 2012, 2013

...during March and April, and again in October, up to 50,000 ducks, 3,000 geese, and several hundred tundra and trumpeter swans...the refuge. The refuge also hosts elk, white- tailed deer, mule deer, pronghorn, and moose. Scoping: Preliminary...

2010-09-17

170

76 FR 12753 - Notice of Temporary Closures on Public Lands in Ada and Elmore Counties, ID  

Federal Register 2010, 2011, 2012, 2013

...hereby given that the Big Fire ( FNW4) and Hot Tea Fire ( FTF6) closures to motorized...their associated habitat in this area. The Hot Tea closure affects public lands in Elmore...burned August 27-29, 2010, by the Hot Tea Fire, 12 miles northwest of...

2011-03-08

171

77 FR 75654 - Notice of Temporary Closures on Public Lands in Owyhee County, ID  

Federal Register 2010, 2011, 2012, 2013

...Land Management (BLM) and Morley Nelson Snake River Birds of Prey National Conservation...contact Patricia Roller, Morley Nelson Snake River Birds of Prey National Conservation...Manager. Patricia Roller, Morley Nelson Snake River Birds of Prey NCA Manager....

2012-12-21

172

78 FR 4869 - Notice of Intent To Collect Fees on Public Land in Clark County, ID  

Federal Register 2010, 2011, 2012, 2013

...Bureau of Land Management (BLM) Upper Snake Field Office is proposing to collect a...BLM's implementing regulations, the Upper Snake Field Office is proposing to charge a group...BLM Idaho State Director. The BLM Upper Snake Field Office will provide final...

2013-01-23

173

78 FR 16523 - Deer Flat National Wildlife Refuge, Canyon, Payette, Owyhee, and Washington Counties, ID, and...  

Federal Register 2010, 2011, 2012, 2013

...including nesting western and Clark's grebes, bald eagles, great blue and black-crowned night herons, Canada geese, and osprey; feeding habitat for a variety of shorebirds including Wilson's phalarope, long- billed curlew, long-billed...

2013-03-15

174

75 FR 1026 - Lower Orogrande Project, Clearwater National Forest, Clearwater County, ID  

Federal Register 2010, 2011, 2012, 2013

...fs.fed.us), Project Leader, Lochsa Ranger...The Lower Orogrande project area contains approximately...improvements include: (1) Decommissioning 6 miles of system roads...being completed for this project; and (3) designating additional stands for management as mature and old...

2010-01-08

175

WATER QUALITY STATUS REPORT, OWYHEE RIVER, OWYHEE COUNTY, ID, 1976-1977.  

EPA Science Inventory

A water quality survey of the Owyhee River in SW Idaho (17050104, 17050105, 17050106) was conducted from August 1976 to April 1977 by the State of Idaho, Department of Health and Welfare, Division of Environment. The survey was conducted to help determine if the Owyhee River in ...

176

77 FR 37702 - Grays Lake National Wildlife Refuge, Caribou and Bonneville Counties, ID; Comprehensive...  

Federal Register 2010, 2011, 2012, 2013

...FWS-R1-ES-2012-N051; 1265-0000-10137-S3] Grays Lake National Wildlife Refuge, Caribou and...comprehensive conservation plan (CCP) for Grays Lake National Wildlife Refuge (refuge, NWR...smith@fws.gov. Include ``Grays Lake CCP EA'' in the subject line of the...

2012-06-22

177

75 FR 41232 - Deer Flat National Wildlife Refuge, Canyon, Owyhee, Payette, and Washington Counties, ID; Malheur...  

Federal Register 2010, 2011, 2012, 2013

...River Islands' grassland, shrub, and riparian forest habitats and surrounding waters provide habitat throughout the year for herons, cormorants, songbirds, and predators such as foxes, coyotes, red-tailed hawks, and American kestrels. [[Page...

2010-07-15

178

Increased expression of Id1 and Id3 promotes tumorigenicity by enhancing angiogenesis and suppressing apoptosis in small cell lung cancer  

PubMed Central

Constant deregulation of Id1 and Id3 has been implicated in a wide range of carcinomas. However, underlying molecular evidence for the joint role of Id1 and Id3 in the tumorigenicity of small cell lung cancer (SCLC) is sparse. Investigating the biological significance of elevated expression in SCLC cells, we found that Id1 and Id3 co-suppression resulted in significant reduction of proliferation rate, invasiveness and anchorage-independent growth. Suppressing both Id1 and Id3 expression also greatly reduced the average size of tumors produced by transfectant cells when inoculated subcutaneously into nude mice. Further investigation revealed that suppressed expression of Id1 and Id3 was accompanied by decreased angiogenesis and increased apoptosis. Therefore, the SCLC tumorigenicity suppression effect of double knockdown of Id1 and Id3 may be regulated through pathways of apoptosis and angiogenesis.

Chen, Danqing; Forootan, Shiva S.; Gosney, John R.; Forootan, Farzad S.; Ke, Youqiang

2014-01-01

179

MADIDS: a novel distributed IDS based on mobile agent  

Microsoft Academic Search

When traditional IDS (Intrusion Detection System) is used to detect and analyze the great flow data transfer in high-speed network, it usually causes the computation bottleneck. This paper presents a new Mobile Agent Distributed IDS (MADIDS) system basing on the mobile agents. This system is specifically designed to process the great flow data transfer in high-speed network. In MADIDS, the

Luo Guangchun; Lu Xianliang; Li Jiong; Zhang Jun

2003-01-01

180

Remote object authentication using distortion-invariant ID tags  

NASA Astrophysics Data System (ADS)

A number of applications in security or inventory control may benefit from an authentication system able to identify a remote object viewed from different perspectives or distances. Object identification can be accomplished by using optical ID tags, which include relevant information of the target and are located on a visible part of the object under surveillance. Encryption of the information codified in the ID tag allows increasing security and deters from unauthorized usage of optical tags. The identification process encompasses several steps such as detection, information decoding and verification which are all detailed in this work. Design of distortion-invariant ID tags has to be taken into account to achieve a correct object authentication even if the ID tag is detected and captured at different distances (i.e. different scales) or from different views (i.e. rotated versions of the original ID tag). Description of diverse distortion-invariant ID tags and authentication results using the proposed ID tags are provided. We show that distortion-tolerance is achieved by the described identification system. Information encrypted on the tested ID tags is correctly decoded and verified even if variations in scale and rotations are considered. The effects of environmental degradation are taken into account in the recognition process.

Perez-Cabre, Elisabet; Millan, Maria S.; Javidi, Bahram

2005-09-01

181

Training MLP neural network to reduce false alerts in IDS  

Microsoft Academic Search

Due to the tremendous growth of the Internet and Network based services, the severity of network based computer attacks have significantly increased. Thus, IDS play a vital role in network security. Intrusion detection system tries to detect computer attacks by examining various data records, log audits etc. Many existing IDS such as Snort are signature based system. The problem with

Prachi Barapatre; N. Z. Tarapore; S. G. Pukale; M. L. Dhore

2008-01-01

182

ID Model Construction and Validation: A Multiple Intelligences Case  

ERIC Educational Resources Information Center

This is a report of a developmental research study that aimed to construct and validate an instructional design (ID) model that incorporates the theory and practice of multiple intelligences (MI). The study consisted of three phases. In phase one, the theoretical foundations of multiple Intelligences and ID were examined to guide the development…

Tracey, Monica W.; Richey, Rita C.

2007-01-01

183

Hancock County Awards Gala  

NASA Technical Reports Server (NTRS)

Gene Goldman (left), deputy director of NASA's John C. Stennis Space Center, accepts an Award of Excellence from Jack Zink, executive director of the Hancock County Port and Harbor Commission, during the 2008 Annual Hancock County Awards Gala. The Award of Excellence was presented to recognize Stennis Space Center's contribution to NASA's 50 years of excellence in space exploration.

2008-01-01

184

County Government Employment: 1990.  

National Technical Information Service (NTIS)

The report provides national statistics on county government employment and payrolls for the month of October 1990. Statistics are based on a mail canvass survey that includes a sample of 2,026 county governments. The survey measures the number of governm...

1991-01-01

185

Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice.  

PubMed

The inhibitor of differentiation Id2 is expressed in mesoderm of the second heart field, which contributes myocardial and mesenchymal cells to the primary heart tube. The role of Id2 in cardiac development is insufficiently known. Heart development was studied in sequential developmental stages in Id2 wildtype and knockout mouse embryos. Expression patterns of Id2, MLC-2a, Nkx2.5, HCN4, and WT-1 were analyzed. Id2 is expressed in myocardial progenitor cells at the inflow and outflow tract, in the endocardial and epicardial lineage, and in neural crest cells. Id2 knockout embryos show severe cardiac defects including abnormal orientation of systemic and pulmonary drainage, abnormal myocardialization of systemic and pulmonary veins, hypoplasia of the sinoatrial node, large interatrial communications, ventricular septal defects, double outlet right ventricle, and myocardial hypoplasia. Our results indicate a role for Id2 in the second heart field contribution at both the arterial and the venous poles of the heart. PMID:22012595

Jongbloed, M R M; Vicente-Steijn, R; Douglas, Y L; Wisse, L J; Mori, K; Yokota, Y; Bartelings, M M; Schalij, M J; Mahtab, E A; Poelmann, R E; Gittenberger-De Groot, A C

2011-11-01

186

76 FR 70865 - Modification of Class E Airspace; Driggs, ID  

Federal Register 2010, 2011, 2012, 2013

...SUMMARY: This action modifies Class E airspace at Driggs, ID to accommodate aircraft using Area Navigation (RNAV) Global Positioning System (GPS) standard instrument approach procedures at Driggs-Reed Memorial Airport. This action also updates the...

2011-11-16

187

Genetics Experts Unite to I.D. Unknown Katrina Victims  

MedlinePLUS

... News From NIH Genetics Experts Unite to I.D. Unknown Katrina Victims Past Issues / Summer 2006 Table ... and genetics," says team member Stephen Sherry, Ph.D., of NLM's National Center for Biotechnology Information, "is ...

188

A Good IDS Response Protocol of MANET Containment Strategies  

NASA Astrophysics Data System (ADS)

Much recent research concentrates on designing an Intrusion Detection System (IDS) to detect the misbehaviors of the malicious node in MANET with ad-hoc and mobility natures. However, without rapid and appropriate IDS response mechanisms performing follow-up management services, even the best IDS cannot achieve the desired primary goal of the incident response. A competent containment strategy is needed to limit the extent of an attack in the Incident Response Life Cycle. Inspired by the T-cell mechanisms in the human immune system, we propose an efficient MANET IDS response protocol (T-SecAODV) that can rapidly and accurately disseminate alerts of the malicious node attacks to other nodes so as to modify their AODV routing tables to isolate the malicious nodes. Simulations are conducted by the network simulator (Qualnet), and the experiment results indicate that T-SecAODV is able to spread alerts steadily while greatly reduce faulty rumors under simultaneous multiple malicious node attacks.

Cheng, Bo-Chao; Chen, Huan; Tseng, Ryh-Yuh

189

75 FR 12974 - Establishment of Class E Airspace; Hailey, ID  

Federal Register 2010, 2011, 2012, 2013

...ID, to accommodate aircraft using the Area Navigation (RNAV) Global Positioning...procedures and air navigation, it is certified...ensure the safety of aircraft and the efficient...Incorporation by reference, Navigation (air)....

2010-03-18

190

4. BUNKER HILL LEAD SMELTER. VIEW IS FROM RIDGE ABOVE ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. BUNKER HILL LEAD SMELTER. VIEW IS FROM RIDGE ABOVE GOVERNMENT GULCH LOOKING TO THE EAST. IN THE RIGHT MID GROUND, CARPENTER SHOP BUILDINGS AND FRAMING SHEDS ARE VISIBLE. THE BACKGROUND FACILITIES VISIBLE FROM L. TO R. ARE: SMELTER OFFICE, REFINERIES, SLAG FUMING STACKS, HIGH VELOCITY FLUE, BAG HOUSE, 200-FOOT STACK, AND 715-FOOT STACK. - Bunker Hill Lead Smelter, Bradley Rail Siding, Kellogg, Shoshone County, ID

191

SIPAR_ID: Freeware for surface irrigation parameter identification  

Microsoft Academic Search

SIPAR_ID is a software based on a robust multiobjective inverse modeling technique for estimating field values of infiltration and roughness parameters of a surface irrigation event under both steady and variable inflow conditions. Its simulation engine is quite flexible and accurate thanks to a hybrid model that combines a volume-balance model with artificial neural networks. SIPAR_ID also provides an estimate

J. A. Rodríguez; J. C. Martos

2010-01-01

192

Accelerated fermentation of 'idli' batter using soy residue okara.  

PubMed

The aim of this work was to reduce the natural fermentation period of 'idli' from the conventional 14 h to 10 h by adding underutilized okara for the preparation of 'idli'. Black gram was partially substituted with soy residue okara in the ratio of (1:1). After 14 h of natural fermentation, the pH and total acidity of control 'idli' batter was 4.51 and 0.64% and that of okara fortified 'idli' batter was 4.53 and 0.43%, respectively. The amount of CO2 released by the control and okara fortified batter was 19.7% and 33.6% respectively. The viable count of yeast and mold, lactics and mesophilic bacteria in control & okara batter increased with time reaching 9.00 & 10.34, 8.66 & 7.69, and 8.65 & 9.47 log10 cfu/g, respectively at the end of 10 h of natural fermentation. Okara fortified 'idli' was soft and spongy compared to control 'idli' . PMID:23572755

Rekha, C R; Vijayalakshmi, G

2011-06-01

193

Distortion-invariant ID tags for object identification  

NASA Astrophysics Data System (ADS)

Active and passive optical identification (ID) tags and readers for remote identification and verification of objects are described. We focus our attention on the design of passive ID tags to achieve distortion-invariant authentication of the information included in the optical tag. A passive ID tag will consist of an optical phase code which can be placed in a visible part of an object for remote detection. We aim to authenticate the object even if the reader captures a distorted version of the code due to in-plane rotations. Distortion-invariance is achieved by both multiplexing the information included in the ID tag and the topology of the tag. For security purposes, double-phase encryption has already been shown as an appropriate technique to encode information. By using double-phase encryption, a signature is hidden in a phase-encoded ID tag not visible by visual inspection. Once the ID tag is captured by the reader and is decrypted, a correlation-based processor verifies the decoded information with a previously stored reference signal. The proposed system may have broad applications in transportation, homeland security, and inventory control.

Perez-Cabre, Elisabet; Javidi, Bahram

2004-11-01

194

SULFUR DIOXIDE SOURCES IN WA, OR, AND ID  

EPA Science Inventory

This map shows industrial plants which emit 100 tons/year or more of sulfur dioxide (SO2) in Idaho, Oregon, and Washington. The SO2 sources are plotted on a background map of cities and county boundaries. Data Sources: SO2 Sites: U.S. EPA AIRS System, County Outlines: USGS, Nat...

195

76 FR 12280 - Revisions to the California State Implementation Plan, for Imperial County, Kern County, and...  

Federal Register 2010, 2011, 2012, 2013

...County, and Ventura County; Air Pollution Control Districts AGENCY: Environmental...revisions to the Imperial County Air Pollution Control District (ICAPCD), Kern County Air Pollution Control District...

2011-03-07

196

76 FR 12306 - Revisions to the California State Implementation Plan, Imperial County, Kern County, and Ventura...  

Federal Register 2010, 2011, 2012, 2013

...County, and Ventura County; Air Pollution Control Districts AGENCY: Environmental...revisions to the Imperial County Air Pollution Control District (ICAPCD), Kern County Air Pollution Control District...

2011-03-07

197

Multimodal biometrics for identity documents (MBioID).  

PubMed

The MBioID initiative has been set up to address the following germane question: What and how biometric technologies could be deployed in identity documents in the foreseeable future? This research effort proposes to look at current and future practices and systems of establishing and using biometric identity documents (IDs) and evaluate their effectiveness in large-scale developments. The first objective of the MBioID project is to present a review document establishing the current state-of-the-art related to the use of multimodal biometrics in an IDs application. This research report gives the main definitions, properties and the framework of use related to biometrics, an overview of the main standards developed in the biometric industry and standardisation organisations to ensure interoperability, as well as some of the legal framework and the issues associated to biometrics such as privacy and personal data protection. The state-of-the-art in terms of technological development is also summarised for a range of single biometric modalities (2D and 3D face, fingerprint, iris, on-line signature and speech), chosen according to ICAO recommendations and availabilities, and for various multimodal approaches. This paper gives a summary of the main elements of that report. The second objective of the MBioID project is to propose relevant acquisition and evaluation protocols for a large-scale deployment of biometric IDs. Combined with the protocols, a multimodal database will be acquired in a realistic way, in order to be as close as possible to a real biometric IDs deployment. In this paper, the issues and solutions related to the acquisition setup are briefly presented. PMID:16890391

Dessimoz, Damien; Richiardi, Jonas; Champod, Christophe; Drygajlo, Andrzej

2007-04-11

198

Id Proteins Regulate Capillary Repair and Perivascular Cell Proliferation following Ischemia-Reperfusion Injury  

PubMed Central

Acute kidney injury (AKI) results in microvascular damage that if not normally repaired, may lead to fibrosis. The Id1 and 3 proteins have a critical role in promoting angiogenesis during development, tumor growth and wound repair by functioning as dominant negative regulators of bHLH transcription factors. The goal of this study was to determine if Id proteins regulate microvascular repair and remodeling and if increased Id1 expression results in decreased capillary loss following AKI. The effect of changes in Id expression in vivo was examined using Id1?/?, Id3RFP/+ (Id1/Id3 KO) and Tek (Tie2)-rtTA, TRE-lacz/TRE Id1 (TRE Id1) mice with doxycycline inducible endothelial Id1 and ?-galactosidase expression. Id1 and 3 were co-localized in endothelial cells in normal adult kidneys and protein levels were increased at day 3 following ischemia-reperfusion injury (IRI) and contralateral nephrectomy. Id1/Id3 KO mice had decreased baseline capillary density and pericyte coverage and increased tubular damage following IRI but decreased interstitial cell proliferation and fibrosis compared with WT littermates. No compensatory increase in kidney size occurred in KO mice resulting in increased creatinine compared with WT and TRE Id1 mice. TRE Id1 mice had no capillary rarefaction within 1 week following IRI in comparison with WT littermates. TRE Id1 mice had increased proliferation of PDGFR? positive interstitial cells and medullary collagen deposition and developed capillary rarefaction and albuminuria at later time points. These differences were associated with increased Angiopoietin 1 (Ang1) and decreased Ang2 expression in TRE Id1 mice. Examination of gene expression in microvascular cells isolated from WT, Id1/Id3 KO and TRE Id1 mice showed increased Ang1 and ?SMA in Id1 overexpressing cells and decreased pericyte markers in cells from KO mice. These results suggest that increased Id levels following AKI result in microvascular remodeling associated with increased fibrosis.

Lee, David; Shenoy, Shantheri; Nigatu, Yezina; Plotkin, Matt

2014-01-01

199

Id proteins regulate capillary repair and perivascular cell proliferation following ischemia-reperfusion injury.  

PubMed

Acute kidney injury (AKI) results in microvascular damage that if not normally repaired, may lead to fibrosis. The Id1 and 3 proteins have a critical role in promoting angiogenesis during development, tumor growth and wound repair by functioning as dominant negative regulators of bHLH transcription factors. The goal of this study was to determine if Id proteins regulate microvascular repair and remodeling and if increased Id1 expression results in decreased capillary loss following AKI. The effect of changes in Id expression in vivo was examined using Id1-/-, Id3RFP/+ (Id1/Id3 KO) and Tek (Tie2)-rtTA, TRE-lacz/TRE Id1 (TRE Id1) mice with doxycycline inducible endothelial Id1 and ?-galactosidase expression. Id1 and 3 were co-localized in endothelial cells in normal adult kidneys and protein levels were increased at day 3 following ischemia-reperfusion injury (IRI) and contralateral nephrectomy. Id1/Id3 KO mice had decreased baseline capillary density and pericyte coverage and increased tubular damage following IRI but decreased interstitial cell proliferation and fibrosis compared with WT littermates. No compensatory increase in kidney size occurred in KO mice resulting in increased creatinine compared with WT and TRE Id1 mice. TRE Id1 mice had no capillary rarefaction within 1 week following IRI in comparison with WT littermates. TRE Id1 mice had increased proliferation of PDGFR? positive interstitial cells and medullary collagen deposition and developed capillary rarefaction and albuminuria at later time points. These differences were associated with increased Angiopoietin 1 (Ang1) and decreased Ang2 expression in TRE Id1 mice. Examination of gene expression in microvascular cells isolated from WT, Id1/Id3 KO and TRE Id1 mice showed increased Ang1 and ?SMA in Id1 overexpressing cells and decreased pericyte markers in cells from KO mice. These results suggest that increased Id levels following AKI result in microvascular remodeling associated with increased fibrosis. PMID:24516656

Lee, David; Shenoy, Shantheri; Nigatu, Yezina; Plotkin, Matt

2014-01-01

200

Inhibitor of Differentiation 1 (Id1) and Id3 Proteins Play Different Roles in TGF? Effects on Cell Proliferation and Migration in Prostate Cancer Cells  

PubMed Central

BACKGROUND In prostate cancer cells, transforming growth factor ? (TGF?) inhibits proliferation in earlier stages of the disease; however, the cancer cells become refractory to growth inhibitory effects in advanced stages where TGF? promotes cancer progression and metastasis. Inhibitor of differentiation (Id) family of closely related proteins (Id1–Id4) are dominant negative regulators and basic helix loop helix (bHLH) transcription factors and in general promote proliferation, and inhibit differentiation. In the present study, we have investigated the role of Id1 and Id3 proteins in the growth inhibitory effects of TGF? on prostate cancer cells. METHODS The effect of TGF ? on proliferation and Id1 and Id3 expression were investigated in PZ-HPV7, DU145, and PC3 cells. Id1 silencing through siRNA was also used in DU145 and PC3 cells to examine its role in anti-proliferative and migratory effects of TGF?. RESULTS TGF? increased expression of Id1 and Id3 in all cell lines followed by a later down regulation of Id1 in PZ-HPV7 expression and DU145 cells but not in PC3 cells. Id3 expression remained elevated in all three cell lines. This loss of Id1 protein correlated with an increase of CDKNI p21. Id1 knockdown in both DU145 and PC3 cells resulted in decreased proliferation. However, while TGF? caused a further decrease in proliferation of DU145, but had no further effects in PC3 cells. Knockdown of Id1 or Id3 inhibited TGF?1 induced migration in PC3 cells. CONCLUSIONS These findings suggest an essential role of Id1 and Id3 in TGF?1 effects on proliferation and migration in prostate cancer cells.

Strong, Nicole; Millena, Ana C.; Walker, Lindsey; Chaudhary, Jaideep; Khan, Shafiq A.

2014-01-01

201

The Self- and Other-Deception Questionnaires-Intellectual Disabilities (SDQ-ID and ODQ-ID): component analysis and reliability.  

PubMed

The objectives of this research were to: (1) investigate the component structure and psychometric properties of the Self- and Other-Deception Questionnaires-Intellectual Disabilities (SDQ-ID and ODQ-ID), (2) examine the relationship between social desirability and IQ, and (3) compare social desirability scores of those with intellectual disabilities (IDs) and a history of criminal offending to the social desirability scores of participants with IDs and those without IDs and no such history, controlling for general intellectual functioning. Men with mild to borderline IDs detained within medium secure inpatient forensic mental health services (N=40) completed the SDQ-ID and ODQ-ID at Time 1 and then two-weeks later at Time 2. Data for the men with and without IDs and no known criminal offending history were taken from a previous study (N=60). Following exploratory Principal Components Analysis, the number of questionnaire items were reduced, and a two-factor structure was found for the SDQ-ID which was labelled: (1) Positive Self Representation and (2) Denial of Intrusive Thoughts. A two-factor structure was also found for the ODQ-ID and these two factors were labelled: (1) Denial of Negative Social Interaction and (2) Untrustworthiness. Both the SDQ-ID and ODQ-ID had acceptable internal consistency and test-retest reliability. Fifteen percent of the variance in SDQ-ID scores was explained by Full Scale IQ, while 21% of the variance in ODQ-ID scores was explained by Full Scale IQ. Between group comparisons controlling for intelligence did not yield any significant differences. The shortened SDQ-ID and ODQ-ID have promising psychometric properties, and their component structures appear robust. Differences between men with and without IDs on these two measures of social desirability can be accounted for by differences in general intellectual functioning. PMID:23962604

Jobson, Laura; Stanbury, Alexandra; Langdon, Peter E

2013-10-01

202

County: Lincoln Station # 014 District: 04 Route: SH75 Ascending Direction: North Segment Code and Milepost: 002230 079.670 6.0 Miles North of North Rail St (Shoshone) Volumes and Percent of Daily Traffic  

Microsoft Academic Search

Hour Volume % of day Volume % of day Volume % of day Volume % of day Volume % of day Volume % of day Volume % of day Volume % of day Volume % of day Volume % of day 0:00 37 0.9% 16 0.4% 12 0.3% 13 0.3% 21 0.5% 22 0.4% 35 0.8% 16 0.4% 36 0.8%

Sunday Monday

2005-01-01

203

Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence  

PubMed Central

Summary The Id (inhibitor of differentiation or DNA binding) family of transcription regulators plays an important role in cell proliferation, differentiation and senescence. However, regulation of Id expression during these processes is poorly understood. Id proteins are known to undergo rapid turnover mediated by the ubiquitin-proteasome pathway. Anaphase-promoting complex has been shown to ubiquitinate Id2, but E3 ubiquitin ligase(s) that ubiquitinate other Id family members are not known. Here we report for the first time the identification of Smurf2 as the E3 ligase that ubiquitinates Id1 and Id3. Smurf2-mediated ubiquitination and consequent degradation of Id1 or Id3 plays an important role in the regulation of Id expression in senescent cells. Furthermore, we found that Id1 is the mediator through which Smurf2 regulates p16 expression, providing a mechanistic link between Smurf2 and p16 expression during senescence.

Kong, Yahui; Cui, Hang; Zhang, Hong

2011-01-01

204

National Dam Inspection Program. Lake Mokoma Dam (NDS-ID Number PA-359, DER ID Number 57-3) Mill Creek, Sullivan County, Pennsylvania. Phase I Inspection Report.  

National Technical Information Service (NTIS)

Lake Mokoma Dam consists of an earth embankment constructed over a timber crib. The outlet works is located approximately 100 feet to the left of the emergency spillway and consists of a wet well, valve and pipe. The emergency spillway is located on the r...

1979-01-01

205

Installation, commissioning and performance of IDs installed at ALBA  

NASA Astrophysics Data System (ADS)

The new synchrotron light source ALBA is currently starting regular operation. Up to 6 beamlines are using light produced by Insertion Devices. There are up to four types of IDs: 2 Apple-II undulators (EU62 and EU71) operating at low energies, one conventional wiggler (MPW80) operating in the range of 2 - 20 keV, two in-vacuum undulators (IVU21) operating in the range 5 - 30 keV and a superconducting wiggler (SCW30) operating in the range of (up to) 40 keV. The main IDs characteristics, their influence on the beam dynamics and a first characterization of their light will be presented.

Campmany, J.; Marcos, J.; Massana, V.; Becheri, F.; Gigante, J. V.; Colldelram, C.; Ribó, Ll

2013-03-01

206

Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like ?? T cells.  

PubMed

The innate-like T cells expressing V?1.1 and V?6.3 represent a unique T cell lineage sharing features with both the ?? T and the invariant NKT cells. The population size of V?1.1(+)V?6.3(+) T cells is tightly controlled and usually contributes to a very small proportion of thymic output, but the underlying mechanism remains enigmatic. Deletion of Id3, an inhibitor of E protein transcription factors, can induce an expansion of the V?1.1(+)V?6.3(+) T cell population. This phenotype is much stronger on the C57BL/6 background than on the 129/sv background. Using quantitative trait linkage analysis, we identified Id2, a homolog of Id3, to be the major modifier of Id3 in limiting V?1.1(+)V?6.3(+) T cell expansion. The V?1.1(+)V?6.3(+) phenotype is attributed to an intrinsic weakness of Id2 transcription from Id2 C57BL/6 allele, leading to an overall reduced dosage of Id proteins. However, complete removal of both Id2 and Id3 genes in developing T cells suppressed the expansion of V?1.1(+)V?6.3(+) T cells because of decreased proliferation and increased cell death. We showed that conditional knockout of Id2 alone is sufficient to promote a moderate expansion of ?? T cells. These regulatory effects of Id2 and Id3 on V?1.1(+)V?6.3(+) T cells are mediated by titration of E protein activity, because removing one or more copies of E protein genes can restore V?1.1(+)V?6.3(+) T cell expansion in Id2 and Id3 double conditional knockout mice. Our data indicated that Id2 and Id3 collaboratively control survival and expansion of the ?? lineage through modulating a proper threshold of E proteins. PMID:24379125

Zhang, Baojun; Lin, Yen-Yu; Dai, Meifang; Zhuang, Yuan

2014-02-01

207

Id1 immortalizes hematopoietic progenitors in vitro and promotes a myeloproliferative disease in vivo  

PubMed Central

Id1 is frequently overexpressed in many cancer cells, but the functional significance of these findings is not known. To determine if Id1 could contribute to the development of hematopoietic malignancy, we reconstituted mice with hematopoietic cells overexpressing Id1. We showed for the first time that deregulated expression of Id1 leads to a myeloproliferative disease in mice, and immortalizes myeloid progenitors in vitro. In human cells, we demonstrate that Id genes are expressed in human acute myelogenous leukemia cells, and that knock down of Id1 expression inhibits leukemic cell line growth, suggesting that Id1 is required for leukemic cell proliferation. These findings established a causal relationship between Id1 overexpression and hematologic malignancy. Thus, deregulated expression of Id1 may contribute to the initiation of myeloid malignancy, and Id1 may represent a potential therapeutic target for early stage intervention in the treatment of hematopoietic malignancy.

Suh, HC; Leeanansaksiri, W; Ji, M; Klarmann, KD; Renn, K; Gooya, J; Smith, D; McNiece, I; Lugthart, S; Valk, PJM; Delwel, R; Keller, JR

2011-01-01

208

County Waterford Image Archive  

NSDL National Science Digital Library

Using volunteer help and a locally written image management system, the Waterford County Museum in Ireland has created this collection of close to 3,000 historical images that document Waterford County and its parishes from the late 1890s to the present. The Web interface to the collection includes a number of helpful features - for those familiar with Waterford county and its place and family names, there is a search box, but for those less familiar there are several ways to browse the collection, by selecting photographer, location, image format, or subjects from drop down lists, as well as selecting parishes from a map to see the pictures associated with each. A photo of the week is posted on the site, and visitors can sign up to receive an RSS feed or, alternatively, an email message when new images are added. There are also easy ways to submit photographs for inclusion in the archive, and for locals to contribute identifying information.

209

IDS alerts classification using knowledge-based evaluation  

Microsoft Academic Search

Most organizations deploy Signature based Intrusion Detection Systems (IDS) to monitor network activities for signs of security violations and these systems generate alerts whenever a known intrusion signature is detected in the network traffic. However, IDSs are known for generating many alerts, most of them being false. This makes the job of security analyst tougher as he\\/she has to sift

Dheeraj Gupta; P. S. Joshi; A. K. Bhattacharjee; R. S. Mundada

2012-01-01

210

Performance of the IDS Method as a Soft Computing Tool  

Microsoft Academic Search

Performance factors such as robustness, speed, and tractability are important for the realization of practical computing systems. The aim of soft computing is to achieve these factors in practice by tolerating imprecision and uncertainty instead of depending on exact mathematical computations. The ink drop spread (IDS) method is a modeling technique that has been proposed as a new approach to

Masayuki Murakami; Nakaji Honda

2008-01-01

211

Delineating soil nutrient management zones based on ID3 algorithm  

Microsoft Academic Search

Focused on the contents of organic matter, total N, available P and available K in patch data of Dehui city, Jilin Province, this paper studies on soil nutrient management zones using decision tree ID3 algorithm. By experimental analysis, we obtain six partitions and the result shows that sub-area differences in soil nutrient content are similar or less significant but differences

Liu He; Cao Liying; Chen Guifen; Li Dexin

2011-01-01

212

Effect of Refrigeration on Inoculated Micro-ID Strips  

PubMed Central

Since reading results after 4 h with the Micro-ID system is not always convenient, a study of 500 isolates indicated that identification at the species level is essentially unchanged when inoculated strips are refrigerated overnight and then incubated or incubated and then refrigerated overnight before reading.

Burdash, Nicholas M.; West, Marcia E.

1981-01-01

213

Two-part transfer pricing improves IDS financial control.  

PubMed

To help coordinate patient care services across its various provider entities, an integrated delivery system (IDS) must address two financial control matters: design of responsibility centers and selection of an appropriate transfer pricing methodology. Although designating an HMO as a profit center is appropriate, such a designation is inappropriate for an IDS's provider entities. Instead, these entities are more appropriately designated as standard expense centers. Further, an HMO owned and operated by an IDS should purchase patient care from the delivery entities by means of two-part transfer prices, that is, having fixed costs paid for in a lump sum and variable costs paid for on the basis of the actual volume and mix of services provided. The IDS's management must recognize, however, that both case mix and volume lie largely outside a hospital's control and that financial controls should focus on a combination of the hospital's fixed costs and variable costs associated with resources per case, efficiency of resource delivery, and factor prices. PMID:10182278

Young, D W

1998-08-01

214

Pierce County Hospital Development Guide.  

National Technical Information Service (NTIS)

A hospital development guide that was developed for Pierce County, Washington is presented. Planning for communitywide hospital development in Pierce County was initiated in 1971, based on a draft report and passage of State certificate of need legislatio...

1974-01-01

215

Biolog(TM) ID as compared to 16S ribosomal RNA ID for environmental isolates from the deep subsurface  

SciTech Connect

The U.S. Dept of Energy (DOE) Subsurface Microbial Culture Collection (SMCC) contains nearly 10,000 strains of microorganisms isolated from terrestrial subsurface environments. Many of the aerobic, gram-negative, chemoheterotrophs isolated from the DOE Savannah River Site (SRS) have previously been identified by phylogenetic analysis of 16S ribosomal RNA (rRNA) gene nucleotide sequences. These SMCC isolates are currently being examined using Biolog GN Microplates and the Biolog Microstation System in order to gain knowledge of their metabolic capabilities and to compare Biolog IDs with 16S IDs. To accommodate the particular needs of these subsurface isolates, which are often incapable of growing under high-nutrient conditions, Biolog's recommendations for inoculating isolates into Biolog GN Microplates have been altered. The isolates are grown on low nutrient media, sodium thioglycolate (3mM) is added to the culture media to inhibit capsule formation, and a low density of bacteria is inoculated into the microplate. Using these altered inoculation criteria, 60 percent of these SMCC isolates have a Biolog genus ID that matches the 16S rRNA ID. These results indicate that the Biolog System can be a good means of identifying unusual environmental isolates, even when recommended inoculation procedures are altered to accommodate particular isolate needs.

McKinsey, P.C.

2000-05-05

216

Housing: Dutchess County.  

National Technical Information Service (NTIS)

One of the most crucial responsibilities of any fast-growing area is that of providing housing for all segments of its population. As pressures for growth are increasingly exerted on Dutchess County, it will be all the more important for the area to know ...

1972-01-01

217

Reviewing County Extension Programs  

ERIC Educational Resources Information Center

An evaluation of the Douglas County (Kansas) Extension Program to determine clientele's level of awareness and acceptance of the program and program strengths and weaknesses, to establish new program directions and a base line for future evaluation efforts, and to develop methodology and materials to be used in evaluation. Procedures, findings,…

Prawl, Warren L.; Jorns, William J.

1976-01-01

218

[Cloning of ID4 gene expression regulation promoter and subcloning of recombinant ID4 promoter luciferase reporter].  

PubMed

The present study was aimed to clone ID4 gene promoter and upstream regulatory region, and to construct a series of recombinant promoter-luciferase reporter for exploring the mechanism of ID4 gene expression regulation. Methods and results: the upstream 5' flanking sequence of 2242 bp from transcriptional start site (TSS) and downstream 5' non-coding region of 212 bp on ID4 gene were searched out and downloaded from human genome databank of NCBI using whole length of ID4 gene cDNA as a probe; On-line promoter analysis softwares, including TESS and Genomax, were employed to analyze the characteristics of ID4 gene promoter and upstream regulatory elements. Then, based on the analytic results, PCR primers were designed and synthesized. Segmental amplification method was adopted to obtain two fragments of 1829 bp and 784 bp. The two fragments were inserted into the plasmid pGEM-T, transformed into TOP10 competent E. coli., and positive recombinants were screened respectively. Subsequently, restriction enzymes KpnI/NheI and KpnI/EcoRI were used to digest the above-mentioned two plasmids pGEM-T and pGL3, and ligation was completed by T4 DNA ligase. After transformation to TOP10 competent E. coli. and screening of positive colonies, the basic recombinant ID4 gene promoter-pGL3 was successfully constructed. KpnI/NheI double digestion and sequencing showed that the target fragment was 2 459 bp and consistent with the corresponding sequence of GenBank; Using the 2459 bp fragment as a template, 5 pairs of primers with identical 3' terminus and different 5' terminus were designed and synthesized for half-nest PCR amplification. 5 fragments with an interval of approximate 400 bp each other, i.e. 2112 bp, 1703 bp, 1290 bp, 784 bp and 496 bp, were produced and inserted into pGEM-T after recovery and purification for transformation to TOP10 competent E. coli. and screening of positive colonies. After that, KpnI/NheI was used to digest the above-mentioned five pGEM-T recombinant plasmids and pGL3 basic vector, and the ligation was completed by T4 DNA ligase. After transformation to TOP10 competent E. coli. and screening for positive colonies, 5 subcloned recombinants of ID4 gene promoter and pGL3 Basic vector cells were constructed. In conclusion, 2.5 kb ID4 gene promoter with upstream expression regulatory sequence was successfully cloned and a series of ID4 promoter subclone-pGL3-Basic recombinant were constructed for further researches on activity, expression regulation and function of ID4 promoter. PMID:20416180

Li, Wei; Huang, Yu; Yang, Bo; Chi, Xiao-Hua; Liu, Li-Hong; Zhang, Feng; Yan, Jiang-Wei; Lu, Xue-Chun

2010-04-01

219

Cell-nonautonomous function of Id1 in the hematopoietic progenitor cell niche  

PubMed Central

Development of hematopoietic stem cells (HSCs) and their immediate progeny is maintained by the interaction with cells in the microenvironment. We found that hematopoiesis was dysregulated in Id1?/? mice. Although the frequency of HSCs in Id1?/? bone marrow was increased, their total numbers remained unchanged as the result of decreased bone marrow cellularity. In addition, the ability of Id1?/? HSCs to self-renew was normal, suggesting Id1 does not affect HSC function. Id1?/? progenitors showed increased cycling in vivo but not in vitro, suggesting cell nonautonomous mechanisms for the increased cycling. Id1?/? HSCs developed normally when transplanted into Id1+/+ mice, whereas the development of Id1+/+ HSCs was impaired in Id1?/? recipients undergoing transplantation and reproduced the hematologic features of Id1?/? mice, indicating that the Id1?/? microenvironment cannot support normal hematopoietic development. Id1?/? stromal cells showed altered production of cytokines in vitro, and cytokine levels were deregulated in vivo, which could account for the Id1?/? hematopoietic phenotypes. Thus, Id1 is required for regulating the hematopoietic progenitor cell niche but is dispensable for maintaining HSCs.

Suh, Hyung Chan; Ji, Ming; Gooya, John; Lee, Michael; Klarmann, Kimberly D.

2009-01-01

220

Entitlement Management: Ready to Enter the IdM Mainstream  

NASA Astrophysics Data System (ADS)

Externalizing authorization processing from business applications has been a goal for architects and developers for many years. Recent compliance demands for more granular access control and policy transparency have increased the urgency to adopt an architectural model where authorization and entitlement management are consumed as a service rather than embedded within business applications. Major software vendors, such as Microsoft, Oracle, and SAP, are making significant steps to separate IdM functionality, including entitlement management from application logic. The market has also responded with a plethora of products that provide entitlement management and authorization functionality for commercial or custom-built application environments. Finally, the Extensible Access Control Markup Language (XACML) has emerged as the consensus authorization standard being supported by a growing number of IT and application vendors. Collectively, these forces form the basis of a nascent IdM market segment referred to as entitlement management.

Gebel, Gerry; Wang, Alice

221

Danger Theory: The Link between AIS and IDS  

Microsoft Academic Search

\\u000a We present ideas about creating a next generation Intrusion Detection System (IDS) based on the latest immunological theories.\\u000a The central challenge with computer security is determining the difference between normal and potentially harmful activity.\\u000a For half a century, developers have protected their systems by coding rules that identify and block specific events. However,\\u000a the nature of current and future threats

Uwe Aickelin; Peter J. Bentley; Steve Cayzer; Kim Jungwon; Julie McLeod

2008-01-01

222

ACE I\\/D polymorphism in Alzheimer’s disease  

Microsoft Academic Search

Angiotensin-converting enzyme (ACE) has been reported to show altered activity in patients with neurological diseases. The\\u000a recent studies found that a 287 bp insertion\\/deletion (I\\/D) polymorphism of the ACE gene may be associated with susceptibility\\u000a to Alzheimer’s disease (AD) but the results have been heterogenous between studies in Europe. In the present study we examined\\u000a for the first time the

Marianna Trebunova; Eva Slaba; Viera Habalova; Zuzana Gdovinova

2008-01-01

223

Redesigning photo-ID to improve unfamiliar face matching performance.  

PubMed

Viewers find it difficult to match photos of unfamiliar faces for identity. Despite this, the use of photographic ID is widespread. In this study we ask whether it is possible to improve face matching performance by replacing single photographs on ID documents with multiple photos or an average image of the bearer. In 3 experiments we compare photo-to-photo matching with photo-to-average matching (where the average is formed from multiple photos of the same person) and photo-to-array matching (where the array comprises separate photos of the same person). We consistently find an accuracy advantage for average images and photo arrays over single photos, and show that this improvement is driven by performance in match trials. In the final experiment, we find a benefit of 4-image arrays relative to average images for unfamiliar faces, but not for familiar faces. We propose that conventional photo-ID format can be improved, and discuss this finding in the context of face recognition more generally. PMID:24749864

White, David; Burton, A Mike; Jenkins, Rob; Kemp, Richard I

2014-06-01

224

Cell-ID Software for Microscope-Based Cytometry  

PubMed Central

This unit describes a method to quantify, from sets of microscope images, various cellular parameters from individual cells, and includes procedures to track cells over time. For example, the user can measure cell volume, total and subcellular localization (nuclear, plasma membrane) of fluorescence for multiple fluorescence channels. This method uses the image processing capabilities of Cell-ID (Gordon et al., 2007) and data analysis by the statistical programming framework R, both open source software packages. The first step for successful cytometry entails acquiring at least one set of images for each field of cells. Each set is composed of one purposefully defocused transmission image (sometimes referred to as brightfield, or BF) that will be used to locate each cell, and one fluorescence image for each of the color channels to be analyzed. Images may be conventional wide-field epifluorescence or confocal microscopy images. Cell-ID processes the images and outputs a tab-delimited file with information extracted from each cell, for each time point and each fluorescence channel. Finally, the user analyzes the data using R (R-Development-Team, 2008), which we have supplemented with a package tailored to analyze Cell-ID output.

Chernomoretz, Ariel; Bush, Alan; Yu, Richard; Gordon, Andrew; Colman-Lerner, Alejandro

2009-01-01

225

Integrated diver display device (ID3) for diver applications  

NASA Astrophysics Data System (ADS)

New underwater computer systems have the potential to provide military divers in operational scenarios with the processing power of laptop or desktop computers. While this computing capability is greatly advancing, heads-up displays (HUDs) currently integrated into dive masks are capable of presenting only limited amounts of operational data. Diver situational awareness can be greatly improved by providing increased imagery for accessing and utilizing all of the processing in these next generation dive computers. In an effort to improve operational efficiency in diver scenarios by providing an enhanced display, the Naval Research Lab leveraged technologies developed for the Immersive Input Display Device (I2D2) in the development of the Integrated Diver Display Device (ID3). The ID3 leverages an organic light emitting diode (OLED) micro-display combined with a magnifying optic to provide a full color SVGA solution within the dive mask without dramatically impacting the diver's line of sight (LOS). By not obstructing LOS, the diver maintains his forward vision and environmental awareness while gaining access to critical situational awareness data. This paper will examine the development and capabilities of the ID3 for dive applications.

Tremper, David; Brosky, Andy

2007-05-01

226

ID3 contributes to cerebrospinal fluid seeding and poor prognosis in medulloblastoma  

PubMed Central

Background The inhibitor of differentiation (ID) genes have been implicated as promoters of tumor progression and metastasis in many human cancers. The current study investigated the expression and functional roles of ID genes in seeding and prognosis of medulloblastoma. Methods ID gene expression was screened in human medulloblastoma tissues. Knockdown of ID3 gene was performed in medulloblastoma cells in vitro. The expression of metastasis-related genes after ID3 knockdown was assessed. The effect of ID3 knockdown on tumor seeding was observed in an animal model in vivo. The survival of medulloblastoma patients was plotted according to the ID3 expression levels. Results Significantly higher ID3 expression was observed in medulloblastoma with cerebrospinal fluid seeding than tumors without seeding. Knockdown of ID3 decreased proliferation, increased apoptosis, and suppressed the migration of D283 medulloblastoma cells in vitro. In a seeding model of medulloblastoma, ID3 knockdown in vivo with shRNA inhibited the growth of primary tumors, prevented the development of leptomeningeal seeding, and prolonged animal survival. High ID3 expression was associated with shorter survival of medulloblastoma patients, especially in Group 4 medulloblastomas. Conclusions High ID3 expression is associated with medullolbastoma seeding and is a poor prognostic factor, especially in patients with Group 4 tumors. ID3 may represent the metastatic/ aggressive phenotype of a subgroup of medulloblastoma.

2013-01-01

227

County Business Patterns 1995  

NSDL National Science Digital Library

The US Census Bureau has made available the state publications for the 1995 version of its annual County Business Patterns 1995 series (Adobe Acrobat [.pdf] format only). Data available include employment, payroll, and number of establishments by Standard Industrial Code category. Establishments are further broken down by nine employment size classes ranging from 1-4 to 1,000 or more. The US volume is forthcoming. Complete 1993 and 1994 (also .pdf format) series are available at the site.

1997-01-01

228

Study of multilayer-reflected beam profiles and their coherence properties using beamlines ID19 (ESRF) and 32-ID (APS)  

SciTech Connect

The use of multilayer mirrors is an interesting alternative for reflective X-ray monochromatization with respect to reflection from crystal optics. The increased photon flux density due to the multilayers' larger bandwidth is of crucial importance for, e.g, full-field X-ray imaging applications. Drawbacks are the introduced modifications of the reflected beam profile as well as a certain loss of coherence, summarized as wavefront degradation. Our recent work has shown that the modification of the beam profile can vary with, e.g., the material composition of the coating applied. In order to verify our findings, a beamline round-robin has been initiated, comparing the wavefront profiles after reflection by selected multilayers at beamlines 32-ID (Advanced Photon Source) and ID19 (European Synchrotron Radiation Facility) with our initial results acquired at BM05 (ESRF) [1].

Rack, A.; Assoufid, L.; Dietsch, R.; Weitkamp, T.; Trabelsi, S. Bauer; Rack, T.; Siewert, F.; Kraemer, M.; Holz, Th.; Zanette, I.; Le, W.-K.; Cloetens, P.; Ziegler, E. [European Synchrotron Radiation Facility, BP220, Grenoble (France); Advanced Photon Source, Argonne National Laboratory, Argonne (United States) and AXO DRESDEN GmbH, Dresden (Germany); Synchrotron Soleil, Gif-sur-Yvette (France); K.I.T. / ANKA light source, Karlsruhe (Germany); Charite, Berlin (Germany); Helmholtz Zentrum Berlin/BESSY-II, Berlin (Germany); AXO DRESDEN GmbH, Dresden (Germany); European Synchrotron Radiation Facility, BP220, Grenoble (France); Advanced Photon Source, Argonne National Laboratory, Argonne (United States); European Synchrotron Radiation Facility, BP220, Grenoble (France)

2012-05-17

229

19. Photocopy of photograph (original print at the Public Service ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. Photocopy of photograph (original print at the Public Service Company of Colorado, Shoshone Hydro Plant Collection, Glenwood Springs, Colorado) Photographer unknown, Circa 1940 SHOSHONE HYDROELECTRIC PLANT - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

230

17. Photocopy of photograph (original print at the Public Service ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photocopy of photograph (original print at the Public Service Company of Colorado, Shoshone Hydro Plant Collection, Glenwood Springs, Colorado) Photographer unknown, Circa 1935 SHOSHONE HYDROELECTRIC PLANT, VIEW TO THE NORTHEAST - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

231

18. Photocopy of photograph (original print at the Public Service ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. Photocopy of photograph (original print at the Public Service Company of Colorado, Shoshone Hydro Plant Collection, Glenwood Springs, Colorado) Photographer unknown, Circa 1935 SHOSHONE HYDROELECTRIC PLANT, VIEW TO THE NORTHWEST - Shoshone Hydroelectric Plant Complex, 60111 U.S. Highway 6, Glenwood Springs, Garfield County, CO

232

76 FR 56356 - Proposed Modification of Class E Airspace; Driggs, ID  

Federal Register 2010, 2011, 2012, 2013

...Airport, Driggs, ID. Controlled airspace is necessary to accommodate aircraft using Area Navigation (RNAV) Global Positioning System (GPS) standard instrument approach procedures at Driggs-Reed Memorial Airport, Driggs, ID. This...

2011-09-13

233

Elevated Id2 expression results in precocious neural stem cell depletion and abnormal brain development  

PubMed Central

Id2 is a helix-loop-helix (HLH) transcription factor essential for normal development and its expression is dysregulated in many human neurological conditions. Although it is speculated that elevated Id2 levels contribute to the pathogenesis of these disorders, it is unknown whether dysregulated Id2 expression is sufficient to perturb normal brain development or function. Here, we show that mice with elevated Id2 expression during embryonic stages develop microcephaly, and that females in particular are prone to generalized tonic-clonic seizures. Analyses of Id2 transgenic brains indicate that Id2 activity is highly cell context specific: elevated Id2 expression in naive NSCs in early neuroepithelium induces apoptosis and loss of NSCs and intermediate progenitors. Activation of Id2 in maturing neuroepithelium results in less severe phenotypes and is accompanied by elevation of G1 Cyclin expression and p53 target gene expression. In contrast, activation of Id2 in committed intermediate progenitors has no significant phenotype. Functional analysis with Id2 over-expressing and Id2-null NSCs shows that Id2 negatively regulates NSC self-renewal in vivo, in contrast to previous cell culture experiments. Deletion of p53 function from Id2-transgenic brains rescues apoptosis and results in increased incidence of brain tumors. Furthermore, Id2 over-expression normalizes the increased self-renewal of p53-null NSCs, suggesting that Id2 activates and modulates the p53 pathway in NSCs. Together, these data suggest that elevated Id2 expression in embryonic brains can cause deregulated NSC self-renewal, differentiation and survival that manifest in multiple neurological outcomes in mature brains, including microcephaly, seizures, and brain tumors.

Park, H.J.; Hong, M.; Bronson, R.T.; Israel, M.A.; Frankel, W. N.; Yun, K.

2013-01-01

234

A Role for Id Proteins in Mammary Gland Physiology and Tumorigenesis  

Microsoft Academic Search

Id helix-loop-helix (HLH) proteins are regulators of cell growth and differentiation in embryonic and adult tissues. They are members of the basic HLH family of transcription factors but lack a DNA binding domain. By binding to basic HLH transcription factors, Id proteins regulate gene expression. Id1 and Id3 have extensive sequence homology and similar patterns of expression during embryogenesis and

Paola de Candia; Robert Benera; David B. Solit

2004-01-01

235

Elevated Id2 expression results in precocious neural stem cell depletion and abnormal brain development.  

PubMed

Id2 is a helix-loop-helix transcription factor essential for normal development, and its expression is dysregulated in many human neurological conditions. Although it is speculated that elevated Id2 levels contribute to the pathogenesis of these disorders, it is unknown whether dysregulated Id2 expression is sufficient to perturb normal brain development or function. Here, we show that mice with elevated Id2 expression during embryonic stages develop microcephaly, and that females in particular are prone to generalized tonic-clonic seizures. Analyses of Id2 transgenic brains indicate that Id2 activity is highly cell context specific: elevated Id2 expression in naive neural stem cells (NSCs) in early neuroepithelium induces apoptosis and loss of NSCs and intermediate progenitors. Activation of Id2 in maturing neuroepithelium results in less severe phenotypes and is accompanied by elevation of G1 cyclin expression and p53 target gene expression. In contrast, activation of Id2 in committed intermediate progenitors has no significant phenotype. Functional analysis with Id2-overexpressing and Id2-null NSCs shows that Id2 negatively regulates NSC self-renewal in vivo, in contrast to previous cell culture experiments. Deletion of p53 function from Id2-transgenic brains rescues apoptosis and results in increased incidence of brain tumors. Furthermore, Id2 overexpression normalizes the increased self-renewal of p53-null NSCs, suggesting that Id2 activates and modulates the p53 pathway in NSCs. Together, these data suggest that elevated Id2 expression in embryonic brains can cause deregulated NSC self-renewal, differentiation, and survival that manifest in multiple neurological outcomes in mature brains, including microcephaly, seizures, and brain tumors. PMID:23390122

Park, Hee Jung; Hong, Mingi; Bronson, Roderick T; Israel, Mark A; Frankel, Wayne N; Yun, Kyuson

2013-05-01

236

Id proteins expression in prostate cancer: high-level expression of Id4 in primary prostate cancer is associated with development of metastases  

Microsoft Academic Search

A major cause of treatment failure for prostate cancer is the development of androgen-independent metastatic disease. Id protein family, a group of basic helix–loop–helix transcription factors, has been shown to be involved in carcinogenesis and a prognostic marker in several types of human cancers. In this study, we examined the expressions of four Id proteins, Id-1, -2, -3 and -4,

Hiu-Fung Yuen; Chee-Wai Chua; Yuen-Piu Chan; Yong-Chuan Wong; Xianghong Wang; Kwok-Wah Chan

2006-01-01

237

An Efficient Method for Identifying IDS Agent Nodes by Discovering Compromised Nodes in MANET  

Microsoft Academic Search

Intrusion detection systems (IDS) for mobile ad hoc networks (MANETs) are necessary when they are deployed in reality. In This paper, we have presented a combined method of selecting IDS agent nodes in mobile ad hoc networks. Since, the IDS agents in MANET due to more activities need to more battery power. In our method, first, compromised nodes are detected

Marjan Kuchaki Rafsanjani; Ali Asghar Khavasi; Ali Movaghar

2009-01-01

238

Molecular interpretation of the main relaxations found ID dielectric spectra of cellulose – experimental arguments  

Microsoft Academic Search

ID dielectric spectra of cellulose two relaxation processes dominate ID the low temperature range (-120 °C–0 °C). For application of the dielectric method as a diagnostic tool, these relaxations must be assigned to molecular motions of the polymeric system. This paper summarizes and discusses all experimental facts found by dielectric spectroscopy, which can help to solve this interpretation problem. ID

Jürgen Einfeldt; Dana Meißner; Albert Kwasniewski

2004-01-01

239

ID box: a multisource attribute data fusion function for target identification  

Microsoft Academic Search

The R&D group at Lockheed-Martin Canada has developed a target identifier function called ID Box. This computer program performs five main functions: first it transforms the sensor attribute input into a few contact ID declarations, second, it evaluates the association score between the contact declarations and the ID propositions of a current target track, third it performs attribute contact to

Marc-Alain Simard; Pierre Valin; Frederic Lesage

2000-01-01

240

Hydrology of Lake County, Florida  

USGS Publications Warehouse

Lake County includes a 1,150 square-mile area consisting of ridges, uplands, and valleys in central-peninsular Florida. About 32 percent of the county is covered by lakes, swamps, and marshes. Water requirements in 1970 averaged about 54 million gallons per day. About 85 percent of the water was obtained from wells; about 15 percent from lakes. The Floridan aquifer supplies almost all the ground water used in Lake County. Annual recharge to the Floridan aquifer averages about 7 inches over the county; runoff average 8.5 inches. The quality of ground and surface water in Lake County is in general good enough for most uses; however, the poor quality of Floridan-aquifer water in the St. John River Valley probably results from the upward movement of saline water along a fault zone. Surface water in Lake County is usually less mineralized than ground water but is more turbid and colored. (Woodard-USGS)

Knochenmus, Darwin D.; Hughes, G. H.

1976-01-01

241

77 FR 72968 - Revisions to the California State Implementation Plan, for Imperial County, Placer County and...  

Federal Register 2010, 2011, 2012, 2013

...Placer County and Ventura County Air Pollution Control Districts AGENCY: Environmental...revisions to the Imperial County Air Pollution Control District (ICAPCD), Placer County Air Pollution Control District (PCAPCD)...

2012-12-07

242

77 FR 73005 - Revisions to the California State Implementation Plan, Imperial County, Placer County, and...  

Federal Register 2010, 2011, 2012, 2013

...Placer County, and Ventura County Air Pollution Control Districts AGENCY: Environmental...revisions to the Imperial County Air Pollution Control District (ICAPCD), Placer County Air Pollution Control District (PCAPCD)...

2012-12-07

243

A study of hysteresis in the K ID -å relation  

Microsoft Academic Search

A photoelastic study of high speed crack propagation in Homalite 100 was conducted to measure hysteresis in the constitutive\\u000a relation forK\\u000a \\u000a ID\\u000a -. The fracture specimen was designed to obtain both crack acceleration and deceleration during a single crack extension.\\u000a Additional loads perpendicular to the crck-propagation path were applied at secondary locations to accentuate the magnitude\\u000a of acceleration-deceleration observed in

J. W. Dally; R. K. Agarwal; R. J. Sanford

1990-01-01

244

Digital Atlas of Texas Counties  

NSDL National Science Digital Library

Created by the Center for Geosptial Technology at Texas Tech University, this digital atlas is a fantastic find. It brings together information about all of Texas's counties, including satellite relief maps and data sets about the roads, rivers, lakes, and other features in each area. Visitors can use the interactive map to click on a county of interest, or use the drop down menu to select a region. Once users select a county, they can download information about it for future use. The site also contains a number of Featured Links to resources from the U.S. Census Bureau, the Texas Association of Counties, and several tourism agencies.

245

75 FR 49016 - County of Greenville, S.C.-Acquisition Exemption-Greenville County Economic Development Corporation  

Federal Register 2010, 2011, 2012, 2013

...Exemption--Greenville County Economic Development Corporation The County of...acquire from Greenville County Economic Development Corporation (GCEDC) approximately...See Greenville County Economic Development...

2010-08-12

246

Calibrating GMOS Spectra to the Lick/IDS Index System  

NASA Astrophysics Data System (ADS)

We present preliminary results on the calibration of Gemini GMOS spectra to the Lick line index system. The Lick system of spectral line indices is one of the most commonly used methods of determining ages and metallicities of unresolved (integrated light) spectral populations. However, care must be taken to calibrate the measured indices to the standard system before making comparisons with models. The calibration of the Lick/IDS system is complicated because the original Lick spectra were not flux calibrated, so there are usually systematic effects due to differences in continuum shape. In addition, the spectra must be broadened to the Lick spectral resolution. Proper calibration involves observing many of the original Lick/IDS standard stars and deriving offsets to the standard system. The indices of the standard stars must bracket the expected indices of the science targets, so many stars may be needed if a wide range of metallicities or ages is expected. We have observed several dozen Lick standard stars with GMOS North and South on the Gemini telescopes and we present details on the data reduction and the initial calibration to the Lick system. Based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the NSF on behalf of the Gemini partnership: the National Science Foundation (United States), the Particle Physics and Astronomy Research Council (United Kingdom), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), CNPq (Brazil), and CONICET (Argentina).

Miller, Bryan W.; Trancho, G.; Puzia, T.

2009-12-01

247

Health Consultation: Tittabawassee River Fish Consumption Health Consultation, Tittabawassee River, Midland, Midland County, Michigan. EPA Facility ID: MID980994354.  

National Technical Information Service (NTIS)

The Agency for Toxic Substances and Disease Registry and Michigan Department of Community Health received a petition about the dioxin contamination along the Tittabawassee River downstream of the city of Midland. Elevated concentrations of dioxin and diox...

2005-01-01

248

Public Health Assessment for Portland Harbor, Multnomah County, Oregon, March 22, 2006. EPA Facility ID: OR0001297969.  

National Technical Information Service (NTIS)

The Superfund Health Investigation and Education (SHINE) program in the Oregon Department of Human Services developed this public health assessment to address the risk of consuming fish and shellfish caught in Portland Harbor. In 2002, the Agency for Toxi...

2006-01-01

249

Health Consultation: Lead Shots in Soils. Brentwood Estates Subdivision, Fairfield Township, Butler County, Ohio. EPA Facility ID: OHN000509195.  

National Technical Information Service (NTIS)

The Health Assessment Section (HAS) at the Ohio Department of Health was asked by the United States Environmental Protection Agency (US EPA) to evaluate site information associated with lead-contaminated soils at the Brentwood Estates subdivision in Fairf...

2006-01-01

250

Public Health Assessment for Annapolis Lead Mine, Annapolis, Iron County, Missouri, September 7, 2006. EPA Facility ID: MO0000958611.  

National Technical Information Service (NTIS)

The Missouri Department of Health and Senior Services (DHSS), in cooperation with the Agency for Toxic Substances and Disease Registry (ATSDR), is evaluating the public health impact of the Annapolis Lead Mine (ALM) Site. ATSDR is a federal agency authori...

2006-01-01

251

Health Consultation: Leroi Company Smelter, Lead Exposure Investigation Results, Northport, Stevens County, Washington. EPA Facility ID: WAD988507323.  

National Technical Information Service (NTIS)

The Washington State Department of Health (DOH) prepared a health consultation in August 2004 evaluating exposure to metals contamination resulting from historic operation of the LeRoi smelter in the town of Northport, Washington. As follow-up to this rep...

2005-01-01

252

Health Consultation: Indoor Air Quality Raytheon Area St. Petersburg, Pinellas County, Florida. EPA Facility ID: FLD0004100152.  

National Technical Information Service (NTIS)

This report addresses the public health threat of possible vapor intrusion from contaminated ground water into buildings above the highest ground water contamination near the Raytheon hazardous waste site in St. Petersburg, Florida. The Florida Department...

2009-01-01

253

Health Consultation: Wyckoff/Eagle Harbor Superfund Site, Bainbridge Island, Kitsap County, Washington. EPA Facility ID: WAD009248295.  

National Technical Information Service (NTIS)

The Agency for Toxic Substances and Disease Registry (ATSDR) prepared this health consultation at the request of the Environmental Protection Agency (EPA) Region 10. The initial ATSDR evaluation for the site was completed in 1990. As part of the 2007 Seco...

2009-01-01

254

Health Consultation: Community Concerns, North Ridge Estates, Klamath Falls, Klamath County, Oregon. EPA Facility ID: ORN001002476.  

National Technical Information Service (NTIS)

The Oregon Department of Human Services/Superfund Health Investigation and Education program (ODHS/SHINE), the Agency for Toxic Substances and Disease Registry (ATSDR), the Oregon Department of Environmental Quality (ODEQ), and the U.S. Environmental Prot...

2006-01-01

255

Public Health Assessment for Laytonville Landfill, Laytonville, Mendocino County, California, March 22, 2005. EPA Facility ID: CAD000065532.  

National Technical Information Service (NTIS)

The California Department of Health Services (CDHS) prepared this public health assessment (PHA) under a cooperative agreement with the federal Agency for Toxic Substances and Disease Registry (ATSDR). PHAs provide communities with information on the spec...

2005-01-01

256

75 FR 70029 - Notice of Temporary Closure of Castle Rocks Inter-Agency Recreation Area in Cassia County, ID  

Federal Register 2010, 2011, 2012, 2013

...Notice of Temporary Closure of Castle Rocks Inter-Agency Recreation Area in Cassia...effect on public lands within the Castle Rocks Inter- Agency Recreation Area that are...lands administered by the BLM at Castle Rocks Inter-Agency Recreation Area in...

2010-11-16

257

Edgecombe County, North Carolina, Land Development Plan.  

National Technical Information Service (NTIS)

The Edgecombe County land development plan has been designed to utilize all possible areas of physical, social and economic potential within the county. The plan is essentially a long range program for the physical development of the county. (Author)

D. L. Pugh

1970-01-01

258

Equity and County College Financing.  

ERIC Educational Resources Information Center

An analysis by the Commission on Financial Postsecondary Education of the system by which New Jersey supports county colleges revealed disparities and inequities among the New Jersey counties in wealth and effort per full-time equivalent student, and current state financing practices that aggravate this problem. In response, alternative state…

New Jersey State Commission on Financing Postsecondary Education, Trenton.

259

Housing Cuyahoga County: Housing Sales.  

National Technical Information Service (NTIS)

The report is one of four which, together, constitute the second year work program of the Cuyahoga County Housing Study. It presents and analyzes data on sales prices of one-family houses in the county, both in aggregate and by small area, in terms of loc...

1971-01-01

260

Menominee: Wisconsin's 72nd County.  

ERIC Educational Resources Information Center

Menominee Indian Reservation became a county after the 1960 Census of Population; therefore, data for the county as a unit were distributed throughout the census publication and appeared as civil division tabulation. This 1963 report attempts to compile these data, as well as data from previous census publications, and present them in easily…

Weidemann, Wayne H.; Fuguitt, Glenn V.

261

Targeting Id1 reduces proliferation and invasion in aggressive human salivary gland cancer cells  

PubMed Central

Background Salivary gland cancer (SGC) is one of the common malignancies of the head and neck area. It develops in the minor and major salivary glands and sometimes metastasizes to other organs, particularly to the lungs. Inhibitors of differentiation (Id) proteins are negative regulators of basic helix-loop-helix transcription factors that control malignant cell behavior and tumor aggressiveness in many tissues. In this study, our goal was to determine the potential role of Id proteins, particularly Id1, during human SGC cell progression. Methods We first determined the expression levels of Id1 and Id2 in four SGC cell lines: two adenocarcinoma of the salivary gland (HSG and HSY) and two adenoid cystic carcinoma (ACC2 and ACCM) cell lines. We then used constructs that expressed antisense cDNAs to Id1 or Id2 to knockdown the expression of these proteins in cell lines where they were highly expressed, and determined the effects of the knockdown on cell proliferation, migration and invasion. Results Id1 mRNA and protein were detectable in all cell lines, and expression of Id2 was variable, from absent to high. The ACC2 and ACCM cell lines expressed both Id1 and Id2, but Id1 was expressed at a higher level in the more aggressive ACCM cell line in comparison toACC2 cells as confirmed by Id1 promoter-reporter assays. We therefore focused on the ACCM cells for the remainder of the study. We found that proliferation and invasiveness of ACCM cells were strongly reduced after Id1 knockdown whereas Id2 suppression had only a slight effect. Results of scratch and colony formation assays also confirmed that ACCM cell aggressiveness was significantly reduced upon Id1 knockdown. Finally, this knockdown resulted in reduced c-myc and enhanced cyclin-dependent kinase inhibitor p21 expression. Conclusions These results demonstrate that Id1 plays an important role in the control of human SGC cell aggressiveness and suggest a potential role as a marker of diagnosis, prognosis and progression of SGCs. Id1 suppression could represent a novel and effective approach for the treatment of salivary gland cancer.

2013-01-01

262

Hydrology of Polk County, Florida  

USGS Publications Warehouse

Local water managers usually rely on information produced at the State and regional scale to make water-resource management decisions. Current assessments of hydrologic and water-quality conditions in Polk County, Florida, commonly end at the boundaries of two water management districts (South Florida Water Management District and the Southwest Florida Water Management District), which makes it difficult for managers to determine conditions throughout the county. The last comprehensive water-resources assessment of Polk County was published almost 40 years ago. To address the need for current countywide information, the U.S. Geological Survey began a 3?-year study in 2002 to update information about hydrologic and water-quality conditions in Polk County and identify changes that have occurred. Ground-water use in Polk County has decreased substantially since 1965. In 1965, total ground-water withdrawals in the county were about 350 million gallons per day. In 2002, withdrawals totaled about 285 million gallons per day, of which nearly 95 percent was from the Floridan aquifer system. Water-conservation practices mainly related to the phosphate-mining industry as well as the decrease in the number of mines in operation in Polk County have reduced total water use by about 65 million gallons per day since 1965. Polk County is underlain by three principal hydrogeologic units. The uppermost water-bearing unit is the surficial aquifer system, which is unconfined and composed primarily of clastic deposits. The surficial aquifer system is underlain by the intermediate confining unit, which grades into the intermediate aquifer system and consists of up to two water-bearing zones composed of interbedded clastic and carbonate rocks. The lowermost hydrogeologic unit is the Floridan aquifer system. The Floridan aquifer system, a thick sequence of permeable limestone and dolostone, consists of the Upper Floridan aquifer, a middle semiconfining unit, a middle confining unit, and the Lower Floridan aquifer. The Upper Floridan aquifer provides most of the water required to meet demand in Polk County. Data from about 300 geophysical and geologic logs were used to construct hydrogeologic maps showing the tops and thicknesses of the aquifers and confining units within Polk County. Thickness of the surficial aquifer system ranges from several feet thick or less in the extreme northwestern part of the county and along parts of the Peace River south of Bartow to more than 200 feet along the southern part of the Lake Wales Ridge in eastern Polk County. Thickness of the intermediate aquifer system/intermediate confining unit is highly variable throughout the county because of past erosional processes and sinkhole formation. Thickness of the unit ranges from less than 25 feet in the extreme northwestern part of the county to more than 300 feet in southwestern Polk County. The altitude of the top of the Upper Floridan aquifer in the county ranges from about 50 feet above National Geodetic Vertical Datum of 1929 (NGVD 29) in the northwestern part to more than 250 feet below NGVD 29 in the southern part. Water levels in the Upper Floridan aquifer fluctuate seasonally, increasing during the wet season (June through September) and decreasing during the rest of the year. Water levels in the Upper Floridan aquifer also can change from year to year, depending on such factors as pumpage and climatic variations. In the southwestern part of the county, fluctuations in water use related to phosphate mining have had a major impact on ground-water levels. Hydrographs of selected wells in southwestern Polk County show a general decline in water levels that ended in the mid-1970s. This water-level decline coincides with an increase in water use associated with phosphate mining. A substantial increase in water levels that began in the mid-1970s coincides with a period of decreasing water use in the county. Despite reductions in water use since 1970, howev

Spechler, Rick M.; Kroening, Sharon E.

2007-01-01

263

A Possible Nonlinearity in IDS / Image Dissector Scanner / Data  

NASA Astrophysics Data System (ADS)

Most of the users of the Image Dissector Scanners mounted on the Boiler & Chivens Cassegrain spectrographs on La Silla will be aware of the high count rate nonlinearity of the IDS. The typical figure for this saturation effect is a 10 per cent loss at count rates in excess of some 2,000 detected events per channel per second. For a linear dispersion of 1.7 Aper channel (171 Aper mm grating) this corresponds to a 10 mag star at the 3.6 m and an 8 mag star at the 1.5 m telescopes. In the following I will report on another nonlinearity effect present at very low light levels, i.e. for count rates below 100 counts per second and channel, and discuss some of the possible sources and implications.

Rosa, M.

1985-03-01

264

Image processing by Intensity-Dependent Spread (IDS)  

NASA Technical Reports Server (NTRS)

As retinal illuminance is lowered, the human visual system integrates the effects of photon absorptions over larger areas and longer times. A theory of the process that might underlie these changes is called Intensity-Dependent Spread (IDS). Each input point gives rise to a pattern of excitation that spreads to a region of the total excitation it sees. The unique aspect of the theory is the assumption that, although the amplitude of the excitation pattern at its center increases with input illuminance, its width decreases in such a way that its volume remains constant. Application of this theory to image processing reveals that it displays a number of unexpected and potentially useful properties. Among them are edge enhancement and independence from scene illumination.

Cornsweet, Tom N.

1989-01-01

265

Behavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in mice  

PubMed Central

SUMMARY Characterizing dopaminergic neuronal development and function in novel genetic animal models might uncover strategies for researchers to develop disease-modifying treatments for neurologic disorders. Id2 is a transcription factor expressed in the developing central nervous system. Id2?/? mice have fewer dopaminergic neurons in the olfactory bulb and reduced olfactory discrimination, a pre-clinical marker of Parkinson’s disease. Here, we summarize behavioral, histological and in vitro molecular biological analyses to determine whether midbrain dopaminergic neurons are affected by Id2 loss. Id2?/? mice were hyperactive at 1 and 3 months of age, but by 6 months showed reduced activity. Id2?/? mice showed age-dependent histological alterations in dopaminergic neurons of the substantia nigra pars compacta (SNpC) associated with changes in locomotor activity. Reduced dopamine transporter (DAT) expression was observed at early ages in Id2?/? mice and DAT expression was dependent on Id2 expression in an in vitro dopaminergic differentiation model. Evidence of neurodegeneration, including activated caspase-3 and glial infiltration, were noted in the SNpC of older Id2?/? mice. These findings document a novel role for Id2 in the maintenance of midbrain dopamine neurons. The Id2?/? mouse should provide unique opportunities to study the progression of neurodegenerative disorders involving the dopamine system.

Havrda, Matthew C.; Paolella, Brenton R.; Ward, Nora M.; Holroyd, Kathryn B.

2013-01-01

266

Impaired Immune Responses and B-Cell Proliferation in Mice Lacking the Id3 Gene  

PubMed Central

B-lymphocyte activation and proliferation induced by the B-cell receptor (BCR) signals are important steps in the initiation of humoral immune responses. How the BCR signals are translated by nuclear transcription factors into cell cycle progression is poorly understood. Id3 is an immediate-early gene responding to growth and mitogenic signals in many cell types including B cells. The primary function of the Id3 protein has been defined as that of inhibitor of basic-helix-loop-helix (bHLH) transcription factors. The interaction between Id3 and bHLH proteins, many of which are essential for cellular differentiation, has been proposed as a key regulatory event leading to cellular proliferation instead of differentiation. To further investigate the role of Id3 in tissue and embryo development and the mechanism of Id3-mediated growth regulation, we generated and analyzed Id3-deficient mice. While these mice display no overt abnormality in tissue and embryo development, their humoral immunity is compromised. The amounts of immunoglobulins produced in Id3-deficient mice immunized with a T-cell-dependent antigen and a type 2 T-cell-independent antigen are attenuated and severely impaired, respectively. Further analysis of lymphocytes isolated from Id3-deficient mice reveals a B-cell defect in their proliferation response to BCR cross-linking but not to lipopolysaccharide or a combination of BCR cross-linking and interleukin-4. Analyses of cultured lymphocytes also suggest involvement of Id3 in cytokine production in T cells and isotype switching in B cells. Finally, the proliferation defect in Id3-deficient B cells can be rescued by ectopic expression of Id1, a homologue of Id3. Taken together, these results define a necessary and specific role for Id3 in mediating signals from BCR to cell cycle progression during humoral immune responses.

Pan, Lihua; Sato, Shinichi; Frederick, Joshua P.; Sun, Xiao-Hong; Zhuang, Yuan

1999-01-01

267

Underground Storage Tank Integrated Demonstration (UST-ID). Technology summary  

SciTech Connect

The DOE complex currently has 332 underground storage tanks (USTs) that have been used to process and store radioactive and chemical mixed waste generated from weapon materials production. Very little of the over 100 million gallons of high-level and low-level radioactive liquid waste has been treated and disposed of in final form. Two waste storage tank design types are prevalent across the DOE complex: single-shell wall and double-shell wall designs. They are made of stainless steel, concrete, and concrete with carbon steel liners, and their capacities vary from 5000 gallons (19 m{sup 3}) to 10{sup 6} gallons (3785 m{sup 3}). The tanks have an overburden layer of soil ranging from a few feet to tens of feet. Responding to the need for remediation of tank waste, driven by Federal Facility Compliance Agreements (FFCAs) at all participating sites, the Underground Storage Tank Integrated Demonstration (UST-ID) Program was created by the US DOE Office of Technology Development in February 1991. Its mission is to focus the development, testing, and evaluation of remediation technologies within a system architecture to characterize, retrieve, treat to concentrate, and dispose of radioactive waste stored in USTs at DOE facilities. The ultimate goal is to provide safe and cost-effective solutions that are acceptable to the public and the regulators. The UST-ID has focused on five DOE locations: the Hanford Site, which is the host site, in Richland, Washington; the Fernald Site in Fernald, Ohio; the Idaho National Engineering Laboratory near Idaho Falls, Idaho; the Oak Ridge Reservation in Oak Ridge, Tennessee, and the Savannah River Site in Savannah River, South Carolina.

Not Available

1994-02-01

268

Mush Creek Watershed, Dallas County and Lowndes County, Alabama.  

National Technical Information Service (NTIS)

The proposal is for the development of a watershed project in Dallas and Lowndes Counties, AL. This project includes an accelerated conservation land treatment program and the installation of floodwater retarding structures. The planned combination of con...

1973-01-01

269

Cutaneous id reactions: a comprehensive review of clinical manifestations, epidemiology, etiology, and management.  

PubMed

Id reactions are a type of secondary inflammatory reaction that develops from a remote localized immunological insult. To date, id reactions caused by various fungal, bacterial, viral, and parasitic infections have been reported. Superficial fungal infections, especially tinea pedis, are the most common cause of id reactions. Id reactions exhibit multiple clinical presentations, including localized or widespread vesicular lesions, maculopapular or scarlatiniform eruptions, erythema nodosum, erythema multiforme, erythema annulare centrifugum, Sweet's syndrome, guttate psoriasis, and autoimmune bullous disease. The mechanisms underlying id reactions vary depending on the type of clinical presentation. The most important aspect of therapy involves the identification and adequate treatment of the underlying infection or dermatitis. This review comprehensively discusses the current state of the field concerning cutaneous id reactions, including diagnostic criteria, clinical presentations, underlying infectious conditions, etiologic agents, immunologic characteristics, histopathologic findings, and management strategies. PMID:22300403

Ilkit, Macit; Durdu, Murat; Karaka?, Mehmet

2012-08-01

270

ID-CoBIT: a battery-less information terminal with data upload capability  

Microsoft Academic Search

This paper presents an ID-CoBIT terminal that can drive an infrared ID tag with no plug-in power source. It also describes an ID sensor system for the terminal. We have been developing the CoBIT (compact battery-less information terminal) system. It can provide information support to users based on their locations and orientations. CoBIT is an ultracompact, low cost information terminal

Yoshiyuki Nakamura; Takuichi Nishimura; Hideo Itoh; Hideyuki Nakashima

2003-01-01

271

Expression of the helix-loop-helix protein, Id, during branching morphogenesis in the kidney  

Microsoft Academic Search

Expression of the helix-loop-helix protein, Id, during branching morphogenesis in the kidney. Id, a member of the helix-loop-helix protein family, is an inhibitor of transcriptional activation by basic-helix-loop-helix proteins. In the developing mouse kidney, Id mRNA was observed as early as 12.5 days post-coitum (dpc) specifically in the condensed mesenchyme surrounding the ureteric buds by in situ hybridization. At 14.5

Melinda K Duncan; Tetsuo Shimamura; Kiran Chada

1994-01-01

272

Id Helix-Loop-Helix Proteins Antagonize Pax Transcription Factor Activity by Inhibiting DNA Binding  

Microsoft Academic Search

The Id subfamily of helix-loop-helix (HLH) proteins plays a fundamental role in the regulation of cellular proliferation and differentiation. The major mechanism by which Id proteins are thought to inhibit differen- tiation is through interaction with other HLH proteins and inhibition of their DNA-binding activity. However, Id proteins have also been shown to interact with other proteins involved in regulating

E. CLAIRE ROBERTS; RICHARD W. DEED; TOSHIAKI INOUE; JOHN D. NORTON; ANDREW D. SHARROCKS

2001-01-01

273

Id-1: Regulator of EGFR and VEGF and potential target for colorectal cancer therapy  

PubMed Central

Background The helix-loop-helix transcription factor Id-1 (an inhibitor of differentiation and DNA binding) plays a role in development and progression of many tumours. Id-1 is known to exert its effects on the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor (VEGF). The aim of this study was to reveal whether there was a relationship between Id-1 and EGFR and VEGF in colorectal carcinoma. Methods Tumour and non-tumour tissue specimens from 46 cases of colorectal carcinoma were exposed to immunohistochemical staining for Id-1, EGFR and VEGF. The relationship between the degree of staining and tumour grade, tumour stage and all tumour markers was investigated. Results Tumour cells showed positive staining for Id-1 in 43 cases (93.5%), for EGFR in 41 cases (89%) and for VEGF in 42 cases (91%). There was a significant relation between the tumour grade and the degree of staining for Id-1, EGFR and VEGF. The relation between the tumour stage and the degree of staining for Id-1, EGFR and VEGF was also significant. There was a significant relation between Id-1 expression and EGFR and VEGF expressions. Non-tumoural tissue specimens were not stained with Id-1 and EGFR antibodies in any of the cases, but stained with VEGF antibody in 3 cases. Conclusion This study revealed that Id-1, EGFR and VEGF took part in development and progression of colorectal carcinomas and that Id-1 was associated with regulations of EGFR and VEGF. The results of this study support the idea that not only EGFR and VEGF but also Id-1 could be new targets in cancer treatment.

Meteoglu, Ibrahim; Meydan, Nezih; Erkus, Muhan

2008-01-01

274

Id expression in amphioxus and lamprey highlights the role of gene cooption during neural crest evolution  

NASA Technical Reports Server (NTRS)

Neural crest cells are unique to vertebrates and generate many of the adult structures that differentiate them from their closest invertebrate relatives, the cephalochordates. Id genes are robust markers of neural crest cells at all stages of development. We compared Id gene expression in amphioxus and lamprey to ask if cephalochordates deploy Id genes at the neural plate border and dorsal neural tube in a manner similar to vertebrates. Furthermore, we examined whether Id expression in these cells is a basal vertebrate trait or a derived feature of gnathostomes. We found that while expression of Id genes in the mesoderm and endoderm is conserved between amphioxus and vertebrates, expression in the lateral neural plate border and dorsal neural tube is a vertebrate novelty. Furthermore, expression of lamprey Id implies that recruitment of Id genes to these cells occurred very early in the vertebrate lineage. Based on expression in amphioxus we postulate that Id cooption conferred sensory cell progenitor-like properties upon the lateral neurectoderm, and pharyngeal mesoderm-like properties upon cranial neural crest. Amphioxus Id expression is also consistent with homology between the anterior neurectoderm of amphioxus and the presumptive placodal ectoderm of vertebrates. These observations support the idea that neural crest evolution was driven in large part by cooption of multipurpose transcriptional regulators from other tissues and cell types.

Meulemans, Daniel; McCauley, David; Bronner-Fraser, Marianne

2003-01-01

275

Bolivar County, Mississippi: Subdivision Regulations.  

National Technical Information Service (NTIS)

The report creates and establishes suggested general rules and regulations for the subdivision of land in Bolivar County, MS. It sets forth transportation and thoroughfare design standards within subdivisions; and outlines administrative enforcement, pena...

1973-01-01

276

County Business Patterns, 1997: Massachusetts.  

National Technical Information Service (NTIS)

County Business Patterns is an annual series that provides subnational economic data by industry. The series is useful for studying the economic activity of small areas; analyzing economic changes over time; and as a benchmark for statistical series, surv...

1999-01-01

277

County Business Patterns, 2004: Massachusetts.  

National Technical Information Service (NTIS)

County Business Patterns is an annual series that provides subnational economic data by industry. The series is useful for studying the economic activity of small areas; analyzing economic changes over time; and as a benchmark for statistical series, surv...

2006-01-01

278

County Business Patterns, 1996: Massachusetts.  

National Technical Information Service (NTIS)

County Business Patterns is an annual series that provides subnational economic data by industry. The series is useful for studying the economic activity of small areas; analyzing economic changes over time; and as a benchmark for statistical series, surv...

1998-01-01

279

County Business Patterns, 2003: Massachusetts.  

National Technical Information Service (NTIS)

County Business Patterns is an annual series that provides subnational economic data by industry. The series is useful for studying the economic activity of small areas; analyzing economic changes over time; and as a benchmark for statistical series, surv...

2005-01-01

280

County Business Patterns: Massachusetts, 2002.  

National Technical Information Service (NTIS)

County Business Patterns is an annual series that provides subnational economic data by industry. The series is useful for studying the economic activity of small areas; analyzing economic changes over time; and as a benchmark for statistical series, surv...

2004-01-01

281

VERMONT COUNTY HEALTH DATA2  

EPA Science Inventory

This datalayer contains Vermont Population and Health data describing public health (1986-2000), by county, extracted from various sources, such as; the Vermont Department of Health, the Vermont Center for Justice Research, the National Institute on Alcohol Abuse & Alcoholis...

282

Dauphin County Opportunity Industrialization Center.  

National Technical Information Service (NTIS)

The goals of the OIC organization in Dauphin County include providing hope for impoverished and hard-core unemployed in the form of job preparation by providing adult education, pre-vocational training, skills training, counseling, job development, placem...

1968-01-01

283

Geothermal development plan: Yuma county  

SciTech Connect

One hot spring and 33 wells drilled in the county discharge water at temperatures sufficient for direct-use geothermal applications such as process heat and space heating and cooling. Currently, one industry within the county has been identified which may be able to use geothermal energy for its process heat requirements. Also, a computer simulation model was used to predict geothermal energy on line as a function of time under both private and city-owned utility development of the resource.

White, D.H.

1981-01-01

284

Geothermal Development Plan: Pima County  

SciTech Connect

Pima County is located entirely within the Basin and Range physiographic province in which geothermal resources are known to occur. Continued growth as indicated by such factors as population growth, employment and income will require large amounts of energy. It is believed that geothermal energy could provide some of the energy that will be needed. Potential users of geothermal energy within the county are identified.

White, D.H.

1981-01-01

285

San Bernardino County Museum  

NSDL National Science Digital Library

The San Bernardino County Museum is a regional museum with exhibits and collections in cultural and natural history. Special exhibits, the Exploration Station live animal discovery center, extensive research collections, and public programs for adults, families, students, and children are all part of the museum experience. The Museum is surrounded by citrus groves, and orange blossoms perfume the air. The Zimmerman Citrus Kiosk explores citrus agricultural history in Southern California. Death Valley Alive! is a new traveling exhibit, available for rent, where visitors can explore the natural history and culture of the Death Valley region from its geologic beginnings 1.3 billion years ago. Online exhibits include The Importance of Museum Collections, The Barstow Fossil Beds, Motherlode of the Miocene, The Etiwanda Fan, and for kids, Mimicry, a study in camouflage and adaptation. Teacher Resources include professional development and workshops, and Trading Places, where 21 hours of time spent volunteering in the Museum earns a free program for your class. Sample opportunities include writing activities for study kits, developing post-visit activities, creating a museum gallery guide, translating student materials into Spanish, or developing an independent idea. There are programs for youth, Scouts, and adults, as well as various publications available in anthropology, archeology, biology, geology and history.

286

Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer  

Microsoft Academic Search

BACKGROUND: Inhibitor of DNA binding\\/Inhibitor of differentiation 4 (ID4) is a critical factor for cell proliferation and differentiation in normal vertebrate development. ID4 has regulative functions for differentiation and growth of the developing brain. The role of ID1, ID2 and ID3 are expected to be oncogenic due to their overexpression in pancreatic cancer and colorectal adenocarcinomas, respectively. Aside from these

Erik Noetzel; Jürgen Veeck; Dieter Niederacher; Oliver Galm; Felicitas Horn; Arndt Hartmann; Ruth Knüchel; Edgar Dahl

2008-01-01

287

Atlas of Historical County Boundaries  

NSDL National Science Digital Library

So you'd like to know the boundaries of Washington's King County in the early 20th century? Or perhaps you'd like to know more about the shape of Nassau County in New York back in the 19th century? The Atlas of Historical County Boundaries can provide you such details. The project is housed at the William M. Scholl Center for American History and Culture at The Newberry Library in Chicago and it was completed in 2010. The Atlas includes such features as all boundary changes in states and countries, non-county areas, separate map or polygon files for every different county configuration, and other helpful features. Users can get started by clicking on different states of interest and just exploring as they see fit. It's also useful to read over the Using the Atlas area for additional assistance. Finally, visitors can also look at the Publications section for more information on the source material for these county boundaries.

288

Pros and Cons of ID vs. 3D Modeling  

NASA Technical Reports Server (NTRS)

Advances in computing capability have led to tremendous improvements in 3D modeling. Entire active regions are being simulated in what might be described as a first principles way, in which plasma heating is treated self consistently rather than through the specification of heating functions. There are limitations to this approach, however, as actual heating mechanisms on the Sun involve spatial scales orders of magnitude smaller than what these simulations can resolve. Other simulations begin to resolve these scales, but they only treat a tiny volume and do not include the all important coupling with larger scales or with other parts of the atmosphere, and so cannot be readily compared with observations. Finally, ID hydrodynamic models capture the field-aligned evolution of the plasma extremely well and are ideally suited for data comparison, but they treat the heating in a totally ad hoc manner. All of these approaches have important contributions to make, but we must be aware of their limitations. I will highlight some of the strengths. and weaknesses of each.

Klimchuk, James A.

2012-01-01

289

Molecular characterization of lactobacilli isolated from fermented idli batter  

PubMed Central

Lactic acid bacteria are non pathogenic organism widely distributed in nature typically involved in a large number of spontaneous food fermentation. The purpose of this study was to characterize the bacteriocinogenic lactobacilli from fermented idli batter which can find application in biopreservation and biomedicine. Eight most promising lactobacilli were chosen from twenty two isolates based on their spectrum of activity against other lactic acid bacteria and pathogens. The eight lactobacilli were characterized based on the various classical phenotypic tests, physiological tests and biochemical tests including various carbohydrate utilization profiles. All isolates were homo fermentative, catalase, and gelatin negative. Molecular characterization was performed by RAPD, 16S rRNA analysis, 16S ARDRA, and Multiplex PCR for species identification. RAPD was carried out using the primer R2 and M13. Five different clusters were obtained based on RAPD indicating strain level variation. 16S rRNA analysis showed 99 to 100% homology towards Lactobacillus plantarum. The restriction digestion pattern was similar for all the isolates with the restriction enzyme AluI. The subspecies were identified by performing Multiplex PCR using species specific primer. Among the five clusters, three clusters were clearly identified as Lactobacillus plantarum subsp. plantarum, Lactobacillus pentosus, and Lactobacillus plantarum subsp. argentoratensis.

Agaliya, Perumal Jayaprabha; Jeevaratnam, Kadirvelu

2013-01-01

290

Molecular characterization of lactobacilli isolated from fermented idli batter.  

PubMed

Lactic acid bacteria are non pathogenic organism widely distributed in nature typically involved in a large number of spontaneous food fermentation. The purpose of this study was to characterize the bacteriocinogenic lactobacilli from fermented idli batter which can find application in biopreservation and biomedicine. Eight most promising lactobacilli were chosen from twenty two isolates based on their spectrum of activity against other lactic acid bacteria and pathogens. The eight lactobacilli were characterized based on the various classical phenotypic tests, physiological tests and biochemical tests including various carbohydrate utilization profiles. All isolates were homo fermentative, catalase, and gelatin negative. Molecular characterization was performed by RAPD, 16S rRNA analysis, 16S ARDRA, and Multiplex PCR for species identification. RAPD was carried out using the primer R2 and M13. Five different clusters were obtained based on RAPD indicating strain level variation. 16S rRNA analysis showed 99 to 100% homology towards Lactobacillus plantarum. The restriction digestion pattern was similar for all the isolates with the restriction enzyme AluI. The subspecies were identified by performing Multiplex PCR using species specific primer. Among the five clusters, three clusters were clearly identified as Lactobacillus plantarum subsp. plantarum, Lactobacillus pentosus, and Lactobacillus plantarum subsp. argentoratensis. PMID:24688512

Agaliya, Perumal Jayaprabha; Jeevaratnam, Kadirvelu

2013-12-01

291

Minimum wafer thickness by rotated ingot ID wafering. [Inner Diameter  

NASA Technical Reports Server (NTRS)

The efficient utilization of materials is critical to certain device applications such as silicon for photovoltaics or diodes and gallium-gadolinium-garnet for memories. A variety of slicing techniques has been investigated to minimize wafer thickness and wafer kerf. This paper presents the results of analyses of ID wafering of rotated ingots based on predicted fracture behavior of the wafer as a result of forces during wafering and the properties of the device material. The analytical model indicated that the minimum wafer thickness is controlled by the depth of surface damage and the applied cantilever force. Both of these factors should be minimized. For silicon, a minimum thickness was found to be approximately 200 x 10 - 6th m for conventional sizes of rotated ingot wafering. Fractures through the thickness of the wafer rather than through the center supporting column were found to limit the minimum wafer thickness. The model suggested that the use of a vacuum chuck on the wafer surface to enhance cleavage fracture of the center supporting core and, with silicon, by using 111-line-type ingots could have potential for reducing minimum wafer thickness.

Chen, C. P.; Leipold, M. H.

1984-01-01

292

Protocol for VOC-Arid ID remediation performance characterization  

SciTech Connect

The Volatile Organic Compound-Arid Integrated Demonstration (VOC-Arid ID) is a technology development program sponsored by the US Department of Energy`s Office of Technology Development that is targeted to acquire, develop, demonstrate, and deploy new technologies for the remediation of VOC contaminants in the soils and groundwaters of arid DOE sites. Technologies cannot be adequately evaluated unless sufficient site characterization and technology performance data have been collection and analyzed. The responsibility for identifying these data needs has been placed largely on the Principal Investigators (PIs) developing the remediation technology, who usually are not experts in site characterization or in identification of appropriate sampling, analysis, and monitoring techniques to support the field testing. This document provides a protocol for planning the collection of data before, during, and after a test of a new technology. This generic protocol provides the PIs and project managers with a set of steps to follow. The protocol is based on a data collection planning process called the Data Quality Objectives (DQO) process, which was originally developed by the US Environmental Protection Agency and has been expanded by DOE to support site cleanup decisions. The DQO process focuses on the quality and quantity of data required to make decision. Stakeholders to the decisions must negotiate such key inputs to the process as the decision rules that will be used and the acceptable probabilities of making decision errors.

Tegner, B.J. [ed.; Hassig, N.L.; Last, G.V.

1994-09-01

293

Susceptibility of hepatoma-derived cells to histone deacetylase inhibitors is associated with ID2 expression  

PubMed Central

Downregulation of inhibitor of DNA binding 2 (ID2) is associated with poor prognosis in cases of hepatocellular carcinoma (HCC). Therefore, to search for effective antitumor drugs for the treatment of HCC exhibiting poor prognostic indicators, we used two HCC-derived cell lines (HuH-7 and HLE) to alter ID2 levels. Specifically, ID2 expression was knocked down in HuH-7 cells via transfection with ID2-specific small interfering RNAs and separately ID2 was overexpressed in HLE cells via an ID2 expression plasmid vector. To assess the effect of antitumor drugs, MTS assay was performed. Annexin V staining was used to evaluate apoptosis and real-time RT-PCR was used to measure mRNA levels. ID2 knockdown cells were more susceptible to histone deacethylase (HDAC) inhibitors including sodium butyrate (NaB), sodium 4-phenyl-butyrate, tricostatin A, suberoylanilide hydroxamic acid, MS-275, apicidin and HC-toxin. Conversely, cells that overexpressed ID2 were less susceptible than control cells to HDAC inhibitors. NaB-induced apoptosis was inversely correlated with ID2 expression. Expression of the anti-apoptotic mRNA BCL2 was induced by NaB in control cells, but this induction of BCL2 was inhibited by ID2 knockdown and strengthened by ID2 overexpression. Expression of another anti-apoptotic mRNA, BCL2L1, was decreased by NaB administration and then partially recovered. However, in ID2 knockdown cells, BCL2L1 levels did not recover from NaB-induced suppression. ID2 affected the susceptibility of two HCC-derived cell lines to an HDAC inhibitor by regulating the expression of anti-apoptotic genes. Therefore, HDAC inhibitors may be effective for the treatment of HCC for which the prognosis is poor based on ID2 downregulation and ID2 could serve as a marker that is predictive of the clinical response to HDAC inhibitors.

TSUNEDOMI, RYOUICHI; IIZUKA, NORIO; HARADA, SAWAKO; OKA, MASAAKI

2013-01-01

294

Water Quality Management Plan: Campbell County, Johnson County, Sheridan County (Wyoming).  

National Technical Information Service (NTIS)

The Powder River Areawide Planning Organization (PRAPO) was designated by the Governor of Wyoming to administer a federal grant for areawide waste treatment planning. The major study area covered Campbell, Johnson and Sheridan Counties in Wyoming. Primary...

1978-01-01

295

Id2 promotes tumor cell migration and invasion through transcriptional repression of Semaphorin 3F  

PubMed Central

Id proteins (Id1-4) are helix-loop-helix transcription factors that promote metastasis. It was found that Semaphorin 3F (SEMA3F), a potent inhibitor of metastasis, was repressed by Id2. High metastatic human tumor cell lines had relatively high amounts of Id2 and low SEMA3F levels compared to their low metastatic counterparts. No correlation between metastatic potential and expression of the other Id family members was observed. Furthermore, ectopic expression of Id2 in low metastatic tumor cells downregulated SEMA3F and, as a consequence, enhanced their ability to migrate and invade, two requisite steps of metastasis in vivo. Id2 overexpression was driven by the c-myc oncoprotein. SEMA3F was a direct target gene of the E47/Id2 pathway. Two E-box sites, which bind E protein transcription factors including E47, were identified in the promoter region of the SEMA3F gene. E47 directly activated SEMA3F promoter activity and expression and promoted SEMA3F biological activities, including F-actin depolymerization, inactivation of RhoA and inhibition of cell migration. Silencing of SEMA3F inhibited the E47-induced SEMA3F expression and biological activities, confirming that these E47-induced effects were SEMA3F-dependent. E47 did not induce expression of the other members of the SEMA3 family. Id2, a dominant-negative inhibitor of E proteins, abrogated the E47-induced SEMA3F expression and biological activities. Thus, high metastatic tumor cells overexpress c-myc, leading to upregulation of Id2 expression; the aberrantly elevated amount of Id2 represses SEMA3F expression and, as a consequence, enhances the ability of tumor cells to migrate and invade.

Coma, Silvia; Amin, Dhara N.; Shimizu, Akio; Lasorella, Anna; Iavarone, Antonio; Klagsbrun, Michael

2010-01-01

296

A human Id-like helix-loop-helix protein expressed during early development.  

PubMed Central

The interaction of helix-loop-helix (HLH) proteins is known to regulate the differentiation of several different tissues, including mammalian muscle and the insect peripheral nervous system. In myoblasts, the products of myogenic HLH genes such as MyoD and ubiquitous HLH proteins such as E12 are present at constant levels throughout development. An E12 monomer and a MyoD monomer form a DNA binding heterodimer that activates muscle-specific genes. These two proteins are unable to dimerize in proliferating myoblasts because a negative regulator HLH protein, Id, is present. We now report the sequence and structure of a human HLH gene related to Id, which has been designated Id-2. Two prominent Id-2 RNA molecules of 2.5 and 1.3 kilobases were found in a number of different human normal and neoplastic tissues. We believe the larger RNA is a precursor of the 1.3-kilobase mRNA that encodes an Id-2 protein of 134 amino acids. The HLH region of the Id-2 protein is 90% homologous to that of myogenic Id, but the homology is much less extensive outside the HLH region. The Id-2 gene is highly expressed during early fetal development in several tissues, including those of the central nervous system, but is not expressed in the corresponding mature tissues. Id-2 expression is modulated in association with retinoic acid-induced ganglionic differentiation of the neuroblastoma cell line SMS-KCNR. These findings suggest that Id-2 is an inhibitor of tissue-specific gene expression, although its distinctive pattern of expression during development suggests a role different from that of Id. Images

Biggs, J; Murphy, E V; Israel, M A

1992-01-01

297

76 FR 33401 - Environmental Impact Statement: Will and Kankakee Counties, Illinois and Lake County, IN  

Federal Register 2010, 2011, 2012, 2013

...Administration Environmental Impact Statement: Will and Kankakee Counties, Illinois and Lake County...that a Tier One Environmental Impact Statement will be prepared for the Illiana Corridor Project in Will and Kankakee Counties, Illinois and Lake...

2011-06-08

298

75 FR 25308 - Environmental Impact Statement: Winnebago County, IL and Rock County, WI  

Federal Register 2010, 2011, 2012, 2013

...Administration Environmental Impact Statement: Winnebago County, IL and Rock County, WI AGENCY: Federal Highway Administration (FHWA...Wisconsin Route 213 and Nye School Road northwest of Beloit, Rock County, Wisconsin to the interchange of Rockton Road and...

2010-05-07

299

New Form of Identity (ID) Theft Crime: Acquiring Personal Information from Your Online Newsletter Providers  

Microsoft Academic Search

Using sophisticated means, Identity (ID) Thieves can acquire victims' personal information for their own deeds from online news providers. This paper discusses how ID Thieves may compile their stock of trade from Directory Harvest Attacks (DHAs) and launch the attacks against online news providers with two possible attack methodologies. This follows by an evaluation of the inadequacy of the current

Gim Hiong Soh; Timo Vuori

2004-01-01

300

78 FR 45478 - Proposed Establishment of Class E Airspace; Salmon, ID  

Federal Register 2010, 2011, 2012, 2013

...Proposed Establishment of Class E Airspace; Salmon, ID AGENCY: Federal Aviation Administration...proposes to establish Class E airspace at the Salmon VHF Omni-Directional Radio Range/Distance...Equipment (VOR/DME) navigation aid, Salmon, ID, to facilitate vectoring of...

2013-07-29

301

Security and Privacy Improvements for the Belgian eID Technology  

NASA Astrophysics Data System (ADS)

The Belgian Electronic Identity Card enables Belgian citizens to prove their identity digitally and to sign electronic documents. At the end of 2009, every Belgian citizen older than 12 years will have such an eID card. In the future, usage of the eID card may be mandatory. However, irresponsible use of the card may cause harm to individuals.

Verhaeghe, Pieter; Lapon, Jorn; de Decker, Bart; Naessens, Vincent; Verslype, Kristof

302

FD, OD, and ID, What's the Relationship: Or--New Wineskins Anyone?  

ERIC Educational Resources Information Center

This paper defines faculty development (FD), organization development (OD), and instructional development (ID), and discusses the interrelationships between them in effecting change in an institution of higher education. FD and OD provide the individual and organizational readiness necessary for adoption of an innovation, while ID focuses on the…

Sachs, Steven G.; Abedor, Allan J.

303

Matching the Judgmental Task with Standard Setting Panelist Expertise: The Item-Descriptor (ID) Matching Method  

ERIC Educational Resources Information Center

Psychometricians continue to introduce new approaches to setting cut scores for educational assessments in an attempt to improve on current methods. In this paper we describe the Item-Descriptor (ID) Matching method, a method based on IRT item mapping. In ID Matching, test content area experts match items (i.e., their judgments about the knowledge…

Ferrara, Steve; Perie, Marianne; Johnson, Eugene

2008-01-01

304

E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.  

PubMed

Disease outcome is known to be influenced by defined subsets of invariant NKT (iNKT) cells residing in distinct locations within peripheral tissue. However, the factors governing the development of these unique iNKT sublineages during thymic development are unknown. In this study we explored the mechanism by which E protein transcription factors and their negative regulators, the Id proteins, control the development of iNKT sublineages after positive selection. We found that E proteins directly bound the promyelocytic leukemia zinc finger (PLZF) promoter and were required for expression of this lineage-defining transcription factor and for the maturation and expansion of thymic iNKT cells. Moreover, expression of the negative regulators of E proteins, Id2 and Id3, defined distinct iNKT cell sublineages. Id3 was expressed in PLZF(high) NKT2 cells and loss of Id3 allowed for increased thymic iNKT cell expansion and abundance of the PLZF(+) NKT2 sublineage. Id2 was expressed in T-BET(+) NKT1 cells, and both Id proteins were required for the formation of this sublineage. Thus, we provide insight into E and Id protein regulation of iNKT cell proliferation and differentiation to specific sublineages during development in the thymus. PMID:24470501

D'Cruz, Louise M; Stradner, Martin H; Yang, Cliff Y; Goldrath, Ananda W

2014-03-01

305

EMERGEncy ID NET: An Emergency Department–Based Emerging Infections Sentinel Network  

Microsoft Academic Search

Acute infectious disease presentations among many at-risk patient groups (eg, uninsured, homeless, and recent immigrants) are frequently seen in emergency departments. Therefore EDs may be useful sentinel sites for infectious disease surveillance. This article describes the background, development, and implementation of EMERGE ncy ID NET, an interdisciplinary, multicenter, ED-based network for research of emerging infectious diseases. EMERGE ncy ID NET

David A Talan; Gregory J Moran; William R Mower; Michael Newdow; Samuel Ong; Laurence Slutsker; William R Jarvis; Laura A Conn; Robert W Pinner

1998-01-01

306

XSSmon: A Perl based IDS for the detection of potential XSS attacks  

Microsoft Academic Search

Recent years have seen an explosion in the number of cross site scripting (XSS) incidents effecting Web sites and Web applications. As such, an intrusion detection system (IDS) capable of detecting potential cross site scripting attacks is demonstrated. The IDS involves the capturing of potential client side executable content on a Web page and the hashing of that content. At

Christopher M. Frenz; Jong P. Yoon

2012-01-01

307

Flaws and frauds in the evaluation of IDS\\/IPS technologies  

Microsoft Academic Search

In this paper, we will briefly review the problem of IDS and IPS perfor- mance evaluation, demonstrating how flawed current approaches to eval- uation are, both in academia and in the industry. We will show all the issues in current testing methodologies, as well as key reasons to distrust claimed performance rates of current IDS systems. We will also show

Stefano Zanero

308

The Numbers Game: Phasing in Generated ID Numbers at the University of Oregon  

ERIC Educational Resources Information Center

With all the recent headlines about security breaches and information loss at financial and educational institutions, the higher education community needs to address the issue of using social security numbers as ID numbers. The University of Oregon undertook a change process to assign generated ID numbers to all records in their information…

Eveland, Sue

2005-01-01

309

Integrated Design System (IDS) Tools for the Spacecraft Aeroassist/Entry Vehicle Design Process  

NASA Technical Reports Server (NTRS)

The definition of the Integrated Design System technology focus area as presented in the NASA Information Technology center of excellence strategic plan is described. The need for IDS tools in the aeroassist/entry vehicle design process is illustrated. Initial and future plans for spacecraft IDS tool development are discussed.

Olynick, David; Braun, Robert; Langhoff, Steven R. (Technical Monitor)

1997-01-01

310

Hold Your Sessions: An Attack on Java Session-Id Generation  

Microsoft Academic Search

HTTP session-id's take an important role in almost any web site today. This paper presents a cryptanalysis of Java Servlet 128-bit session-id's and an efficient practical prediction algorithm. Using this attack an adversary may impersonate a legitimate client. Through the analysis we also present a novel, general space-time tradeoff for secure pseudo random number generator attacks.

Zvi Gutterman; Dahlia Malkhi

2005-01-01

311

Long-range optical character recognition for product ID  

NASA Astrophysics Data System (ADS)

An automated product tag reading system based on CCD cameras and computer image processing has been developed by West Virginia University and demonstrated at the Weirton Steel Corporation. The system reads both a 50-mil barcode and a string of six numbers on a four-inch by six-inch tag fastened to the end of a steel slab. Feedback from the image is used to point and zoom the camera, making the system effective at ranges up to thirty feet, and in bright sunlight-situations where handheld barcode scanners are ineffective. A video camera is mounted on a pan/tilt head and connected to a personal computer through a frame grabber board. The whole system is mounted on a slab hauler--a huge wheeled machine for carrying 100 tons of steel slabs at a time. The slab hauler backs into position and presses `start' on a touchscreen operator interface. A wide-angle image is grabbed, and the computer analyzes the images to find product ID tags in scene. The camera is then zoomed and pointed one-by-one at the tags for closeup images. Geometric warping is done on the closeup images to correct for viewing angle distortion, and both the barcode and the alphanumeric code are read by the software and reported to the inventory management system via radio modern. This paper discusses the neural network-based system for reading the characters on the tag. The camera pointing system and barcode reader are discussed in a companion paper.

Banta, Larry E.; Pertl, Franz A.; Rosenberry-Friend, Kimberly A.

1998-10-01

312

TGF-?1-induced expression of Id-1 is associated with tumor progression in gastric cancer.  

PubMed

Transforming growth factor ?1 (TGF-?1) and inhibitor of differentiation/DNA-binding 1 (Id-1) have been shown to be associated with aggressive metastatic behavior of cancer cells in many malignant tumors. However, their role in gastric cancer (GC) has not been established. In this study, we investigated the relationship between expression of Id-1 and TGF-?1 in GC as well as their association with GC progression. The immunohistochemical analysis of 71 human GC samples indicated that both Id-1 and TGF-?1 were markedly upregulated in tumor tissue compared with the adjacent tissue; in addition, a significant positive correlation was found between the expression levels of Id-1 and TGF-?1 by Pearson's correlation analysis. Furthermore, the investigation of the association of Id-1 and TGF-?1 with patient clinical characteristics revealed that Id-1 expression was significantly correlated with tumor differentiation, while TGF-?1 was associated with lymph node metastasis. The results were validated in vitro by using a GC cell line, AGS. The expression of Id-1 was upregulated at 24 and 48 h after the treatment with TGF-?1, whereas it did not affect the proliferation of cells. TGF-?1 also influenced the expression of N-cadherin and ?-catenin. Our results suggested that Id-1 and TGF-?1 played important roles in the progression of GC, in which Id-1 might act as a downstream mediator of TGF-?1 signaling through a regulatory mechanism involving N-cadherin and ?-catenin. The TGF-?1/Id-1 axis might serve as a future therapeutic target for GC. PMID:24861919

Ma, Huiying; Wei, Ye; Leng, Yongmei; Li, Shichao; Gao, Lingling; Hu, Heng; Chen, Long; Wang, Fei; Xiao, Honglei; Zhu, Chouwen; Liang, Chunmin

2014-07-01

313

A short Id2 protein fragment containing the nuclear export signal forms amyloid-like fibrils  

SciTech Connect

The negative regulator of DNA-binding/cell-differentiation Id2 is a small protein containing a central helix-loop-helix (HLH) motif and a C-terminal nuclear export signal (NES). Whereas the former is essential for Id2 dimerization and nuclear localization, the latter is responsible for the transport of Id2 from the nucleus to the cytoplasm. Whereas the isolated Id2 HLH motif is highly helical, large C-terminal Id2 fragments including the NES sequence are either unordered or aggregation-prone. To study the conformational properties of the isolated NES region, we synthesized the Id2 segment 103-124. The latter was insoluble in water and only temporarily soluble in water/alcohol mixtures, where it formed quickly precipitating {beta}-sheets. Introduction of a positively charged N-terminal tail prevented aggressive precipitation and led to aggregates consisting of long fibrils that bound thioflavin T. These results show an interesting structural aspect of the Id2 NES region, which might be of significance for both protein folding and function.

Colombo, Noemi [Fakultaet fuer Chemie und Pharmazie, Universitaet Regensburg, Universitaetsstrasse 31, 93053 Regensburg (Germany); Schroeder, Josef [Institut fuer Pathologie, Zentrales EM-Labor, Fakultaet fuer Medizin, Universitaet Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg (Germany); Cabrele, Chiara [Fakultaet fuer Chemie und Pharmazie, Universitaet Regensburg, Universitaetsstrasse 31, 93053 Regensburg (Germany)]. E-mail: chiara.cabrele@chemie.uni-regensburg.de

2006-07-21

314

Id-1 is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target  

PubMed Central

Glioblastoma (GBM) is the most common form of primary adult brain tumors. A majority of GBMs grow invasively into distant brain tissue, leading to tumor recurrence, which is ultimately incurable. It is, therefore, essential to discover master regulators that control GBM invasiveness and target them therapeutically. We demonstrate here that the transcriptional regulator Id-1 plays a critical role in modulating the invasiveness of GBM cell lines and primary GBM cells. Id-1 expression levels positively correlate with glioma cell invasiveness in culture and with histopathological grades in patient biopsies. Id-1 knockdown dramatically reduces GBM cell invasion that is accompanied by profound morphological changes and robust reduction in expression levels of “mesenchymal” markers, as well as inhibition of self-renewal potential and down-regulation of glioma stem cell markers. Importantly, genetic knockdown of Id-1 leads to a significant increase in survival in an orthotopic model of human GBM. Furthermore, we show that a non-toxic compound, cannabidiol, significantly down-regulates Id-1 gene expression and associated glioma cell invasiveness and self-renewal. Additionally, cannabidiol significantly inhibits the invasion of GBM cells through an organotypic brain slice and glioma progression in vivo. Our results suggest that Id-1 regulates multiple tumor-promoting pathways in GBM, and that drugs targeting Id-1 represent a novel and promising strategy for improving the therapy and outcome of GBM patients.

Soroceanu, Liliana; Murase, Ryuichi; Limbad, Chandani; Singer, Eric; Allison, Juanita; Adrados, Isabel; Kawamura, Rumi; Pakdel, Arash; Fukuyo, Yayoi; Nguyen, Daniel; Khan, Sabeena; Arauz, Robert; Yount, Garret L.; Moore, Dan H.; Desprez, Pierre-Yves; McAllister, Sean D.

2012-01-01

315

Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis  

PubMed Central

High-grade gliomas (HGGs) are incurable brain tumors that are characterized by the presence of glioma-initiating cells (GICs). GICs are essential to tumor aggressiveness and retain the capacity for self-renewal and multilineage differentiation as long as they reside in the perivascular niche. ID proteins are master regulators of stemness and anchorage to the extracellular niche microenvironment, suggesting that they may play a role in maintaining GICs. Here, we modeled the probable therapeutic impact of ID inactivation in HGG by selective ablation of Id in tumor cells and after tumor initiation in a new mouse model of human mesenchymal HGG. Deletion of 3 Id genes induced rapid release of GICs from the perivascular niche, followed by tumor regression. GIC displacement was mediated by derepression of Rap1gap and subsequent inhibition of RAP1, a master regulator of cell adhesion. We identified a signature module of 5 genes in the ID pathway, including RAP1GAP, which segregated 2 subgroups of glioma patients with markedly different clinical outcomes. The model-informed survival analysis together with genetic and functional studies establish that ID activity is required for the maintenance of mesenchymal HGG and suggest that pharmacological inactivation of ID proteins could serve as a therapeutic strategy.

Niola, Francesco; Zhao, Xudong; Singh, Devendra; Sullivan, Ryan; Castano, Angelica; Verrico, Antonio; Zoppoli, Pietro; Friedmann-Morvinski, Dinorah; Sulman, Erik; Barrett, Lindy; Zhuang, Yuan; Verma, Inder; Benezra, Robert; Aldape, Ken; Iavarone, Antonio; Lasorella, Anna

2012-01-01

316

Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.  

PubMed

High-grade gliomas (HGGs) are incurable brain tumors that are characterized by the presence of glioma-initiating cells (GICs). GICs are essential to tumor aggressiveness and retain the capacity for self-renewal and multilineage differentiation as long as they reside in the perivascular niche. ID proteins are master regulators of stemness and anchorage to the extracellular niche microenvironment, suggesting that they may play a role in maintaining GICs. Here, we modeled the probable therapeutic impact of ID inactivation in HGG by selective ablation of Id in tumor cells and after tumor initiation in a new mouse model of human mesenchymal HGG. Deletion of 3 Id genes induced rapid release of GICs from the perivascular niche, followed by tumor regression. GIC displacement was mediated by derepression of Rap1gap and subsequent inhibition of RAP1, a master regulator of cell adhesion. We identified a signature module of 5 genes in the ID pathway, including RAP1GAP, which segregated 2 subgroups of glioma patients with markedly different clinical outcomes. The model-informed survival analysis together with genetic and functional studies establish that ID activity is required for the maintenance of mesenchymal HGG and suggest that pharmacological inactivation of ID proteins could serve as a therapeutic strategy. PMID:23241957

Niola, Francesco; Zhao, Xudong; Singh, Devendra; Sullivan, Ryan; Castano, Angelica; Verrico, Antonio; Zoppoli, Pietro; Friedmann-Morvinski, Dinorah; Sulman, Erik; Barrett, Lindy; Zhuang, Yuan; Verma, Inder; Benezra, Robert; Aldape, Ken; Iavarone, Antonio; Lasorella, Anna

2013-01-01

317

ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2.  

PubMed

Dendritic cells (DCs) comprise two major subsets, the interferon (IFN)-producing plasmacytoid DCs (pDCs) and antigen-presenting classical DCs (cDCs). The development of pDCs is promoted by E protein transcription factor E2-2, whereas E protein antagonist Id2 is specifically absent from pDCs. Conversely, Id2 is prominently expressed in cDCs and promotes CD8(+) cDC development. The mechanisms that control the balance between E and Id proteins during DC subset specification remain unknown. We found that the loss of Mtg16, a transcriptional cofactor of the ETO protein family, profoundly impaired pDC development and pDC-dependent IFN response. The residual Mtg16-deficient pDCs showed aberrant phenotype, including the expression of myeloid marker CD11b. Conversely, the development of cDC progenitors (pre-DCs) and of CD8(+) cDCs was enhanced. Genome-wide expression and DNA-binding analysis identified Id2 as a direct target of Mtg16. Mtg16-deficient cDC progenitors and pDCs showed aberrant induction of Id2, and the deletion of Id2 facilitated the impaired development of Mtg16-deficient pDCs. Thus, Mtg16 promotes pDC differentiation and restricts cDC development in part by repressing Id2, revealing a cell-intrinsic mechanism that controls subset balance during DC development. PMID:24980046

Ghosh, Hiyaa S; Ceribelli, Michele; Matos, Ines; Lazarovici, Allan; Bussemaker, Harmen J; Lasorella, Anna; Hiebert, Scott W; Liu, Kang; Staudt, Louis M; Reizis, Boris

2014-07-28

318

Prototype Planning Study: Middlesex County, New Jersey.  

National Technical Information Service (NTIS)

Middlesex County, New Jersey is experiencing transportation problems. To help solve escalating traffic problems on the county roads, they explored the potential of transportation systems management (TSM) techniques. The strategies they investigated fell i...

1979-01-01

319

Cherokee County Kansas Lead Surveillance Program.  

National Technical Information Service (NTIS)

The Cherokee County Kansas Lead Surveillance Program was conducted as a two year screening program (1994-1996) by Kansas Department of Health and Environment and Cherokee County Health Department with funds made available by Agency for Toxic Substances an...

B. Fulghum D. Mulnix S. N. Paige

1998-01-01

320

Solid Waste Management Plan, Emmet County.  

National Technical Information Service (NTIS)

The Solid Waste Management Plan for Emmet County suggests economically feasible solid waste collection and disposal systems. Georgraphic factors related to County land area, outstanding natural resources, and soil conditions represent strong elements in t...

1973-01-01

321

E47 and Id1 Interplay in Epithelial-Mesenchymal Transition  

PubMed Central

E12/E47 proteins (encoded by E2A gene) are members of the class I basic helix-loop-helix (bHLH) transcription factors (also known as E proteins). E47 has been described as repressor of E-cadherin and inducer of epithelial-mesenchymal transition (EMT). We reported previously that EMT mediated by E47 in MDCK cells occurs with a concomitant overexpression of Id1 and Id3 proteins. Id proteins belong to class V of HLH factors that lack the basic domain; they dimerise with E proteins and prevent their DNA interaction, thus, acting as dominant negative of E proteins. Here, we show that E47 interacts with Id1 in E47 overexpressing MDCK cells that underwent a full EMT as well as in mesenchymal breast carcinoma and melanoma cell lines. By conducting chromatin immunoprecipitation assays we demonstrate that E47 binds directly to the endogenous E-cadherin promoter of mesenchymal MDCK-E47 cells in a complex devoid of Id1. Importantly, our data suggest that both E47 and Id1 are required to maintain the mesenchymal phenotype of MDCK-E47 cells. These data support the collaboration between E47 and Id1 in the maintenance of EMT by mechanisms independent of the dominant negative action of Id1 on E47 binding to E-cadherin promoter. Finally, the analysis of several N0 breast tumour series indicates that the expression of E47 and ID1 is significantly associated with the basal-like phenotype supporting the biological significance of the present findings.

Cubillo, Eva; Moreno-Bueno, Gema; Peinado, Hector; Montes, Amalia; Santos, Vanesa; Portillo, Francisco; Cano, Amparo

2013-01-01

322

COX-2 overexpression increases malignant potential of human glioma cells through Id1.  

PubMed

Increased COX-2 expression directly correlates with glioma grade and is associated with shorter survival in glioblastoma (GBM) patients. COX-2 is also regulated by epidermal growth factor receptor signaling which is important in the pathogenesis of GBMs. However, COX-2 expression has not been previously shown to directly alter malignancy of GBMs. Id1 is a member of the helix-loop-helix (HLH) family of transcriptional repressors that act as dominant-negative inhibitors of basic-HLH factors. This factor has been shown to be regulated by COX-2 in breast carcinoma cells and recent studies suggest that Id1 may also be involved in the genesis/progression of gliomas. We now show that COX-2 increases the aggressiveness of GBM cells. GBM cells with COX-2 overexpression show increased growth of colonies in soft agar. Tumorigenesis in vivo is also increased in both subcutaneous flank and orthotopic intracranial tumor models. COX-2 overexpression induces Id1 expression in two GBM cell lines suggesting a role for Id1 in glioma transformation/tumorigenesis. Furthermore, we find direct evidence of a role for Id1 with significant suppression of in vitro transformation and in vivo tumorigenesis in COX-2-overexpressing GBM cells where Id1 has been knocked down. In fact, Id1 is even more efficient at enhancing transformation/tumorigenesis of GBM cells than COX-2. Finally, GBM cells with COX-2 or Id1 overexpression show greater migration/invasive potential and tumors that arise from these cells also display increased microvessel density, results in line with the increased malignant potential seen in these cells. Thus, COX-2 enhances the malignancy of GBM cells through induction of Id1. PMID:24659686

Xu, Kaiming; Wang, Lanfang; Shu, Hui-Kuo G

2014-03-15

323

COX-2 overexpression increases malignant potential of human glioma cells through Id1  

PubMed Central

Increased COX-2 expression directly correlates with glioma grade and is associated with shorter survival in glioblastoma (GBM) patients. COX-2 is also regulated by epidermal growth factor receptor signaling which is important in the pathogenesis of GBMs. However, COX-2 expression has not been previously shown to directly alter malignancy of GBMs. Id1 is a member of the helix-loop-helix (HLH) family of transcriptional repressors that act as dominant-negative inhibitors of basic-HLH factors. This factor has been shown to be regulated by COX-2 in breast carcinoma cells and recent studies suggest that Id1 may also be involved in the genesis/progression of gliomas. We now show that COX-2 increases the aggressiveness of GBM cells. GBM cells with COX-2 overexpression show increased growth of colonies in soft agar. Tumorigenesis in vivo is also increased in both subcutaneous flank and orthotopic intracranial tumor models. COX-2 overexpression induces Id1 expression in two GBM cell lines suggesting a role for Id1 in glioma transformation/tumorigenesis. Furthermore, we find direct evidence of a role for Id1 with significant suppression of in vitro transformation and in vivo tumorigenesis in COX-2-overexpressing GBM cells where Id1 has been knocked down. In fact, Id1 is even more efficient at enhancing transformation/tumorigenesis of GBM cells than COX-2. Finally, GBM cells with COX-2 or Id1 overexpression show greater migration/invasive potential and tumors that arise from these cells also display increased microvessel density, results in line with the increased malignant potential seen in these cells. Thus, COX-2 enhances the malignancy of GBM cells through induction of Id1.

Xu, Kaiming; Wang, Lanfang; Shu, Hui-Kuo G.

2014-01-01

324

Id1 Expression Promotes T Regulatory Cell Differentiation by Facilitating TCR Costimulation.  

PubMed

T regulatory (Treg) cells play crucial roles in the regulation of cellular immunity. The development of Treg cells depends on signals from TCRs and IL-2Rs and is influenced by a variety of transcription factors. The basic helix-loop-helix proteins are known to influence TCR signaling thresholds. Whether this property impacts Treg differentiation is not understood. In this study, we interrogated the role of basic helix-loop-helix proteins in the production of Treg cells using the CD4 promoter-driven Id1 transgene. We found that Treg cells continued to accumulate as Id1 transgenic mice aged, resulting in a significant increase in Treg cell counts in the thymus as well as in the periphery compared with wild-type controls. Data from mixed bone marrow assays suggest that Id1 acts intrinsically on developing Treg cells. We made a connection between Id1 expression and CD28 costimulatory signaling because Id1 transgene expression facilitated the formation of Treg precursors in CD28(-/-) mice and the in vitro differentiation of Treg cells on thymic dendritic cells despite the blockade of costimulation by anti-CD80/CD86. Id1 expression also allowed in vitro Treg differentiation without anti-CD28 costimulation, which was at least in part due to enhanced production of IL-2. Notably, with full strength of costimulatory signals, however, Id1 expression caused modest but significant suppression of Treg induction. Finally, we demonstrate that Id1 transgenic mice were less susceptible to the induction of experimental autoimmune encephalomyelitis, thus illustrating the impact of Id1-mediated augmentation of Treg cell levels on cellular immunity. PMID:24920844

Liu, Chen; Wang, Hong-Cheng; Yu, Sen; Jin, Rong; Tang, Hui; Liu, Yuan-Feng; Ge, Qing; Sun, Xiao-Hong; Zhang, Yu

2014-07-15

325

Id2 and Id3 Inhibit Development of CD34 1 Stem Cells into Predendritic Cell (Pre-DC)2 but Not into Pre-DC1: Evidence for a Lymphoid Origin of Pre-DC2  

Microsoft Academic Search

We found previously that Id3, which inhibits transcriptional activities of many basic helix- loop-helix transcription factors, blocked T and B cell development but stimulated natural killer (NK) cell development. Here we report that ectopic expression of Id3 and another Id protein, Id2, strongly inhibited the development of primitive CD34 1 CD38 2 progenitor cells into CD123 high dendritic cell (DC)2

Hergen Spits; Franka Couwenberg; Arjen Q. Bakker; Kees Weijer; Christel H. Uittenbogaart

326

76 FR 29721 - Lost River and Challis-Yankee Fork Ranger Districts, Salmon-Challis National Forest; ID; Lost...  

Federal Register 2010, 2011, 2012, 2013

...Challis-Yankee Fork Ranger Districts, Salmon- Challis National Forest; ID; Lost...National Forest System lands managed by the Salmon-Challis National Forest. This project...Lands Center, 1206 S. Challis Street, Salmon, ID 83467; telephone:...

2011-05-23

327

76 FR 12733 - Shenzhen Tangreat Technology Co., Ltd., Grantee of Equipment Authorization FCC ID No. XRLTG-VIPJAMM  

Federal Register 2010, 2011, 2012, 2013

...Shenzhen Tangreat Technology Co., Ltd., Grantee of Equipment Authorization FCC ID No...Technology Co., Ltd. (``Shenzhen''), Grantee of Equipment Authorization FCC ID No...TG-VIPJAMM'') is assigned by the grantee or applicant. \\3\\ 47 U.S.C....

2011-03-08

328

Underemployment Estimates by County, United States, 1960.  

ERIC Educational Resources Information Center

This is a collection of estimates, by county, of the unutilized labor due to underemployment in 1960. This technique of determining unemployment uses the national median income adjusted for each country's age-color mix, education status, and an employment factor, to provide a county standard against which the actual county median income can be…

Kampe, Ronald E.; Lindamood, William A.

329

Water Management in Cache County, Utah  

Microsoft Academic Search

Cache County is one of the biggest agricultural producers in Utah and over 70% of the county's water is used for irrigation. In this project, we use NASA's Terrestrial Observation and Prediction System (TOPS) and Moderate Resolution Imaging Spectroradiometer (MODIS) data to gain an understanding of the water cycle in Cache County by comparing the precipitation, snowpack, and runoff amounts

G. Zhang; K. Lowry; R. Nemani; C. Schmidt; J. Skiles

2008-01-01

330

Community Types and Mortality in Georgia Counties  

ERIC Educational Resources Information Center

Using an "ecological regional analysis" methodology for defining types of communities and their associated mortality rates, this study of Georgia's 159 counties finds that the suburban and town centered counties have low mortality while the city-centered type predicts low mortality for the whites. The military-centered counties do not predict. The…

Young, Frank W.

2012-01-01

331

The Bridge of Mandolin County  

Microsoft Academic Search

The Bridge of Mandolin County is a case designed to teach the general chemistry principles of molar mass, ions and aqueous reactions, solubility rules, and inorganic nomenclature. Through the instructor-facilitated class discussion, students consider the options before the Mandolin Town Council regarding deicing the newly constructed bridge connecting Mandolin with a large nearby city. The students must decipher contradictory claims

Juliette M. Lantz; Jenny E. Feindt; Eric P. B. Lewellyn; Mary M. Walczak

1999-01-01

332

GEOPHAGY IN A MISSISSIPPI COUNTY  

Microsoft Academic Search

Geophagy (earth eating) is practiced by black women and black children of both sexes, but by few or none of the adult black males in Holmes County, Mississippi. Geophagy does not stem from physiological disorder nor appetite aberration. It appears to be a custom brought by slaves from the Old World. Edible clays are obtained from the B soil horizon.

DONALD E. VERMEER; DENNIS A. FRATE

1975-01-01

333

Natural Decrease in Texas Counties.  

ERIC Educational Resources Information Center

In replication of other studies, the natural decrease of Texas population was examined in terms of the effect of migration and fertility. Utilizing Texas and U.S. vital statistics and the 1970 U.S. Census of Population, Texas population trends were analyzed for the 1968-72 period by dividing the 254 Texas counties into: (1) 65 natural decrease…

Koebernick, Thomas E.; Markides, Kyriakos S.

334

76 FR 30152 - East Calloway County Middle School Mercury Spill Site, Murray, Calloway County, KY; Notice of...  

Federal Register 2010, 2011, 2012, 2013

...FRL-9310-4] East Calloway County Middle School Mercury Spill Site, Murray, Calloway County...the East Calloway County Middle School Mercury Spill Site located in Murray, Calloway...County [[Page 30153

2011-05-24

335

Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer  

Microsoft Academic Search

ID4 gene is a member of the inhibitor of DNA-binding (ID) family, which inhibits DNA binding of basic helix–loop–helix transcription factors. Certain human primary breast cancers reportedly have low or no expression of ID4 protein, but its role in carcinogenesis and cancer progression is unknown. To determine its possible role, we examined epigenetic inactivation of ID4 gene by promoter hypermethylation

Naoyuki Umetani; Takuji Mori; Kazuo Koyanagi; Masaru Shinozaki; Joseph Kim; Armando E Giuliano; Dave S B Hoon; DSB Hoon

2005-01-01

336

A Cysteine Residue in the Helix-Loop-Helix Domain of Id2 Is Critical for Homodimerization and Function  

Microsoft Academic Search

Id proteins are negative regulators of basic helix-loop-helix (bHLH) transcription factors. In this study, we compared the expression of Id2 mRNA in proliferating (fetal) and nonproliferating (adult) alveolar epithelial cells (AECs). The expression of Id2 was higher in adult AECs than in the corresponding fetal cells, suggesting that Id2 might play a functional role in developmental regulation of lung epithelial

Jian Liu; Wei Shi; David Warburton

2000-01-01

337

The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues  

SciTech Connect

Highlights: •Sodium arsenite induces cytoplasmic accumulation of Id3. •Arsenite binds to closely spaced N-terminal cysteine residues of Id3. •N-terminal cysteines are essential for arsenite-induced nuclear export of Id3. •Nuclear export of Id3 counteracts its transcriptional repression activity. -- Abstract: Ids are versatile transcriptional repressors that regulate cell proliferation and differentiation, and appropriate subcellular localization of the Id proteins is important for their functions. We previously identified distinct functional nuclear export signals (NESs) in Id1 and Id2, but no active NES has been reported in Id3. In this study, we found that treatment with the stress-inducing metalloid arsenite led to the accumulation of GFP-tagged Id3 in the cytoplasm. Cytoplasmic accumulation was impaired by a mutation in the Id3 NES-like sequence resembling the Id1 NES, located at the end of the HLH domain. It was also blocked by co-treatment with the CRM1-specific nuclear export inhibitor leptomycin B (LMB), but not with the inhibitors for mitogen-activated protein kinases (MAPKs). Importantly, we showed that the closely spaced N-terminal cysteine residues of Id3 interacted with the arsenic derivative phenylarsine oxide (PAO) and were essential for the arsenite-induced cytoplasmic accumulation, suggesting that arsenite induces the CRM1-dependent nuclear export of Id3 via binding to the N-terminal cysteines. Finally, we demonstrated that Id3 significantly repressed arsenite-stimulated transcription of the immediate-early gene Egr-1 and that this repression activity was inversely correlated with the arsenite-induced nuclear export. Our results imply that Id3 may be involved in the biological action of arsenite.

Kurooka, Hisanori, E-mail: hkurooka@u-fukui.ac.jp [Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui (Japan) [Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui (Japan); Research and Education Program for Life Science, University of Fukui, Fukui (Japan); Sugai, Manabu [Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto (Japan)] [Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto (Japan); Mori, Kentaro [Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui (Japan)] [Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui (Japan); Yokota, Yoshifumi, E-mail: yokota@u-fukui.ac.jp [Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui (Japan) [Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui (Japan); Research and Education Program for Life Science, University of Fukui, Fukui (Japan)

2013-04-19

338

Family Impact in Intellectual Disability, Severe Mental Health Disorders and Mental Health Disorders in ID. A Comparison  

ERIC Educational Resources Information Center

Family impact (or family burden) is a concept born in the field of mental health that has successfully been exported to the ambit of intellectual disability (ID). However, differences in family impact associated with severe mental health disorders (schizophrenia), to ID or to mental health problems in ID should be expected. Seventy-two adults with…

Martorell, Almudena; Gutierrez-Recacha, Pedro; Irazabal, Marcia; Marsa, Ferran; Garcia, Mercedes

2011-01-01

339

Wnt/{beta}-catenin signaling changes C2C12 myoblast proliferation and differentiation by inducing Id3 expression  

SciTech Connect

Highlights: Black-Right-Pointing-Pointer Expression of Id3 but not Id1 is induced by Wnt3a stimulation in C2C12 cells. Black-Right-Pointing-Pointer Wnt3a induces Id3 expression via canonical Wnt/{beta}-catenin pathway. Black-Right-Pointing-Pointer Wnt3a-induced Id3 expression does not depend on BMP signaling activation. Black-Right-Pointing-Pointer Induction of Id3 expression is critical determinant in Wnt3a-induced cell proliferation and differentiation. -- Abstract: Canonical Wnt signaling plays important roles in regulating cell proliferation and differentiation. In this study, we report that inhibitor of differentiation (Id)3 is a Wnt-inducible gene in mouse C2C12 myoblasts. Wnt3a induced Id3 expression in a {beta}-catenin-dependent manner. Bone morphogenetic protein (BMP) also potently induced Id3 expression. However, Wnt-induced Id3 expression occurred independent of the BMP/Smad pathway. Functional studies showed that Id3 depletion in C2C12 cells impaired Wnt3a-induced cell proliferation and alkaline phosphatase activity, an early marker of osteoblast cells. Id3 depletion elevated myogenin induction during myogenic differentiation and partially impaired Wnt3a suppressed myogenin expression in C2C12 cells. These results suggest that Id3 is an important Wnt/{beta}-catenin induced gene in myoblast cell fate determination.

Zhang, Long; Shi, Songting; Zhang, Juan; Zhou, Fangfang [Dept. of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden (Netherlands)] [Dept. of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden (Netherlands); Dijke, Peter ten, E-mail: p.ten_dijke@lumc.nl [Dept. of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden (Netherlands)

2012-03-02

340

78 FR 25406 - Proposed Modification of Class E Airspace; Twin Falls, ID  

Federal Register 2010, 2011, 2012, 2013

...Airport, Twin Falls, ID. Controlled airspace is necessary to accommodate aircraft using the Area Navigation (RNAV) Global Positioning System (GPS) and the Instrument Landing System (ILS) or Localizer (LOC) standard instrument approach procedures...

2013-05-01

341

76 FR 46721 - Salmon-Challis National Forest, ID; Upper North Fork HFRA Ecosystem Restoration Project...  

Federal Register 2010, 2011, 2012, 2013

...ID; Upper North Fork HFRA Ecosystem Restoration Project Environmental Impact Statement...integrated hazardous fuels and forest restoration project in the Upper North Fork drainage...environmental analysis under the Healthy Forest Restoration Act (HFRA) of 2003. A...

2011-08-03

342

78 FR 9029 - Nez Perce-Clearwater National Forests; ID; Clear Creek Integrated Restoration Project  

Federal Register 2010, 2011, 2012, 2013

...Forests; ID; Clear Creek Integrated Restoration Project AGENCY: Forest Service, USDA...actions in the Clear Creek Integrated Restoration Draft Environmental Impact Statement...standard for the Clear Creek Integrated Restoration project area. The original notice...

2013-02-07

343

The balance between Pax5 and Id2 activities is the key to AID gene expression.  

PubMed

Pax5 activity is enhanced in activated B cells and is essential for class switch recombination (CSR). We show that inhibitor of differentiation (Id)2 suppresses CSR by repressing the gene expression of activation-induced cytidine deaminase (AID), which has been shown to be indispensable for CSR. Furthermore, a putative regulatory region of AID contains E2A- and Pax5-binding sites, and the latter site is indispensable for AID gene expression. Moreover, the DNA-binding activity of Pax5 is decreased in Id2-overexpressing B cells and enhanced in Id2(-/-) B cells. The kinetics of Pax5, but not E2A, occupancy to AID locus is the same as AID expression in primary B cells. Finally, enforced expression of Pax5 induces AID transcription in pro-B cell lines. Our results provide evidence that the balance between Pax5 and Id2 activities has a key role in AID gene expression. PMID:14581609

Gonda, Hiroyuki; Sugai, Manabu; Nambu, Yukiko; Katakai, Tomoya; Agata, Yasutoshi; Mori, Kazuhiro J; Yokota, Yoshifumi; Shimizu, Akira

2003-11-01

344

78 FR 773 - Hartford Financial Services Group, Inc., Commercial/Actuarial/Information Delivery Services (IDS...  

Federal Register 2010, 2011, 2012, 2013

...IDS)/Corporate & Financial Reporting Group, Hartford, CT; Notice of Affirmative Determination Regarding Application...investigation resulted in a negative determination based on the findings that with respect to Section 222(a) and Section...

2013-01-04

345

78 FR 40382 - Modification of Class D and E Airspace; Twin Falls, ID  

Federal Register 2010, 2011, 2012, 2013

...Field-Magic Valley Regional Airport, Twin Falls, ID, to accommodate aircraft using the Navigation (RNAV) Global Positioning System (GPS) and the Instrument Landing System (ILS) or Localizer (LOC) standard instrument approach...

2013-07-05

346

Identification of an alternative transcript from the human iduronate-2-sulfatase (IDS) gene  

SciTech Connect

Iduronate-2-sulfatase (IDS) is involved in the degradation of heparan sulfate and dermatan sulfate in the lysosomes, and a deficiency in this enzyme results in Hunter syndrome. A 2.3-kb cDNA clone that contains the entire coding sequence of IDS has previously been reported. Here we describe the identification of a 1.4-kb transcript that may encode an IDS-like enzyme. The predicted protein is identical to the previously described enzyme, except for the absence of the 207-amino-acid COOH-terminal domain, which is replaced by 7 amino acids. Our data suggest that there might exist an additional form of the IDS enzyme in humans. The results from this study may have implications for the pathogenesis of the Hunter syndrome. 16 refs., 2 figs.

Malmgren, H.; Carlberg, B.M.; Petterson, U. [Univ. of Uppsala (Sweden)] [and others] [Univ. of Uppsala (Sweden); and others

1995-09-01

347

Modulation of IdUrd-DNA incorporation and radiosensitization in human bladder carcinoma cells  

SciTech Connect

5' Amino-5'-deoxythymidine (5'-AdThd) has been demonstrated previously to antagonize dTTP-mediated feedback inhibition of purified thymidine kinase from 647V, a human bladder cancer cell line. Low concentrations of 5'-AdThd (3-30 microM) have also been shown to stimulate cellular uptake of iododeoxyuridine (IdUrd) in 647V cells at clinically relevant IdUrd concentrations (2 microM). We report that the combination of 30 microM 5'-AdThd plus 2 microM IdUrd results in a significant increase of IdUrd replacement of thymidine (dThd) (18%) in the DNA of 647V cells over that obtained by exposure to 2 microM IdUrd alone (7.9%). However, increasing the 5'-AdThd concentration to 300 microM inhibited the incorporation of IdUrd into DNA (3%). IdUrd-induced radiosensitization of 647V cells, as measured by clonogenic survival, was enhanced by coincubation with 30 microM 5'-AdThd, while 300 microM 5'-AdThd reduced the IdUrd radiosensitization. Additionally, radiation-induced single strand break generation when IdUrd was incorporated into 647V DNA, as measured by rapid alkaline elution, was also enhanced by coincubation with 30 microM 5'-AdThd, while 300 microM 5'-AdThd resulted in a decrease in the number of single strand breaks produced. In T24, another bladder cancer cell line, and SV-HUC-TT1, a tumorigenic cell line derived from SV-HUC, 3-10 microM 5'-AdThd was also able to enhance IdUrd replacement of dThd in DNA. However, no stimulation of dThd replacement by 5'-AdThd occurred in SV-HUC, a prototypic normal bladder urothelial cell line. Since 5'-AdThd is not a substrate for mammalian thymidine kinase and has little or no cytotoxicity in vitro and in vivo, it may be a selective modulator of IdUrd radiosensitization of human bladder carcinoma and should be tested in vivo.

Kunugi, K.A.; Vazquez-Padua, M.A.; Miller, E.M.; Kinsella, T.J. (Univ. of Wisconsin, Madison (USA))

1990-08-15

348

Ameliorative effect of IDS 30, a stinging nettle leaf extract, on chronic colitis  

Microsoft Academic Search

Background and aims Anti-TNF-? antibodies are very effective in the treatment of acute Crohn’s disease, but are limited by the decline of their effectiveness after repeated applications. The stinging nettle leaf extract, IDS 30, is an adjuvant remedy in rheumatic diseases dependent on a cytokine suppressive effect. We investigated the effect of IDS 30 on disease activity of murine colitis in different

Astrid Konrad; Michael Mähler; Stephan Arni; Beatrice Flogerzi; Sonja Klingelhöfer; Frank Seibold

2005-01-01

349

Effects of 3?-hydroxyfarrerol (IdB 1031), a novel flavonoid agent, on phagocyte products  

Microsoft Academic Search

The novel flavonoid compound 3'-hydroxyfarrerol (IdB 1031) was tested in a number of in vitro experiments in order to ascertain its effects on some functions and products of human phagocytes. We found that IdB 1031 did not depress neutrophil phagocytosis and chemotaxis, whereas at a concentration of 10-4 M it significantly (p}) reduced the fMLP-triggered neutrophil production of superoxide anion.

Federica Meloni; Piercarla Ballabio; Marina Gorrini; Mara De Amici; Carlo Marena; Salvatore Malandrino; Maurizio Luisetti

1995-01-01

350

Id proteins synchronize stemness and anchorage to the niche of neural stem cells  

PubMed Central

Stem-cell functions require activation of stem-cell-intrinsic transcriptional programs and extracellular interaction with a niche microenvironment. How the transcriptional machinery controls residency of stem cells in the niche is unknown. Here we show that Id proteins coordinate stem-cell activities with anchorage of neural stem cells (NSCs) to the niche. Conditional inactivation of three Id genes in NSCs triggered detachment of embryonic and postnatal NSCs from the ventricular and vascular niche, respectively. The interrogation of the gene modules directly targeted by Id deletion in NSCs revealed that Id proteins repress bHLH-mediated activation of Rap1GAP, thus serving to maintain the GTPase activity of RAP1, a key mediator of cell adhesion. Preventing the elevation of the Rap1GAP level countered the consequences of Id loss on NSC–niche interaction and stem-cell identity. Thus, by preserving anchorage of NSCs to the extracellular environment, Id activity synchronizes NSC functions to residency in the specialized niche.

Niola, Francesco; Zhao, Xudong; Singh, Devendra; Castano, Angelica; Sullivan, Ryan; Lauria, Mario; Nam, Hyung-song; Zhuang, Yuan; Benezra, Robert; Di Bernardo, Diego; Iavarone, Antonio; Lasorella, Anna

2013-01-01

351

Modeling Sj?gren's Syndrome with Id3 Conditional Knockout Mice  

PubMed Central

The Id3 gene has been shown to play important roles in the development and function of broad tissue types including B and T cells. Id3 deficient mice develop autoimmune disease similar to human Sjögren’s syndrome. Both B and T lymphocytes have been implicated to contribute to the disease phenotype in this disease model. In order to gain a better understanding of individual cell types in this disease model, we generated an Id3 conditional allele. An LckCre transgene was used to induce Id3 deletion in developing T cells. We showed that the Id3 gene was efficiently disrupted in early thymocyte development prior to T cell receptor (TCR)-mediated positive selection. Consequently, thymocyte maturation was impaired in the conditional knockout mice. These mice developed exocrinopathy starting at two months of age and subsequently exhibited high incidence of lymphocyte infiltration to salivary glands between eight and 12 months of age. This progressive feature of disease development is very similar to those observed in Id3 germline knockout mice. This study establishes a new model for investigating the relationship between T cell development and autoimmune disease. Our observation provides an experimental case that autoimmune disease may be induced by acquired mutation in developing T cells.

Guo, Zengli; Li, Hongmei; Han, Min; Xu, Tian; Wu, Xiaohui; Zhuang, Yuan

2010-01-01

352

Zebrafish id2 developmental expression pattern contains evolutionary conserved and species-specific characteristics.  

PubMed

The inhibitor of differentiation or inhibitor of DNA binding (Id) family are members of the helix-loop-helix (HLH) group of transcription factors that play important roles in cell proliferation, differentiation, cell cycle control, and apoptosis. They modulate the formation of active class A-class B basic HLH (bHLH) complexes. Ids lack the amino-terminal associated basic region necessary for DNA binding, thus sequestering the class A factors, inhibiting the formation of active class A-class B heterodimers and, therefore, are considered to act as dominant-negative regulators of differentiation pathways. We isolated zebrafish id2, and its expression during development was characterized. id2, in addition to regions of expression detected in Xenopus and mice, is also expressed in the tegmentum; midbrain-hindbrain boundary; cerebellum; rhombomeres 2,3,4,6; notochord; and corpuscles of Stannius. Furthermore, we show that expression of id2 is repressed in mind bomb mutants, suggesting a role of Notch upstream of Id2. PMID:16252281

Chong, Shang-Wei; Nguyen, Thi-Thu-Hang; Chu, Lee-Thean; Jiang, Yun-Jin; Korzh, Vladimir

2005-12-01

353

Id proteins synchronize stemness and anchorage to the niche of neural stem cells.  

PubMed

Stem-cell functions require activation of stem-cell-intrinsic transcriptional programs and extracellular interaction with a niche microenvironment. How the transcriptional machinery controls residency of stem cells in the niche is unknown. Here we show that Id proteins coordinate stem-cell activities with anchorage of neural stem cells (NSCs) to the niche. Conditional inactivation of three Id genes in NSCs triggered detachment of embryonic and postnatal NSCs from the ventricular and vascular niche, respectively. The interrogation of the gene modules directly targeted by Id deletion in NSCs revealed that Id proteins repress bHLH-mediated activation of Rap1GAP, thus serving to maintain the GTPase activity of RAP1, a key mediator of cell adhesion. Preventing the elevation of the Rap1GAP level countered the consequences of Id loss on NSC-niche interaction and stem-cell identity. Thus, by preserving anchorage of NSCs to the extracellular environment, Id activity synchronizes NSC functions to residency in the specialized niche. PMID:22522171

Niola, Francesco; Zhao, Xudong; Singh, Devendra; Castano, Angelica; Sullivan, Ryan; Lauria, Mario; Nam, Hyung-song; Zhuang, Yuan; Benezra, Robert; Di Bernardo, Diego; Iavarone, Antonio; Lasorella, Anna

2012-05-01

354

Association between ACE gene I/D polymorphism and clinical presentation and prognosis of sarcoidosis.  

PubMed

Serum angiotensin converting enzyme (SACE) concentration is considered a marker of sarcoidosis activity. This concentration is influenced by an insertion/deletion (I/D) polymorphism of the ACE gene, such that SACE levels follow the pattern DD>ID>II. The aim of our work was to study the relationship between I/D polymorphism and susceptibility to sarcoidosis, as well as the relation between this polymorphism and the clinical presentation and evolution of the disease in 177 sarcoidosis patients. A group of 104 individuals without sarcoidosis was included as control. Genotyping was done by a polymerase chain reaction (PCR) method, and SACE concentration at diagnosis was determined by a kinetic method. No differences were observed in genotype or allele distributions between patients and controls, nor between patients considering the type of presentation (Löfgren versus non-Löfgren) and evolution of the disease (acute versus chronic). As reported for healthy populations, SACE concentrations followed the pattern DD>ID>II in sarcoidosis patients, but significant differences between genotypes existed only in the Löfgren group (p = 0.003) and in acute patients (p = 0.02). SACE concentrations at diagnosis were lower in acute patients (p = 0.05) and in Löfgren's syndrome (p = 0.04), but this seemed to occur only in ID individuals (p = 0.02 and p = 0.01, respectively). No relation was thus found between I/D polymorphism and susceptibility to sarcoidosis, but ACE I/D genotyping may improve the assessment of disease activity, both at diagnosis and during the follow-up of treated and untreated patients. PMID:16319043

Alía, P; Mañá, J; Capdevila, O; Alvarez, A; Navarro, M A

2005-01-01

355

Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.  

PubMed

Three complete cDNA clones encoding Id-related helix-loop-helix (HLH) proteins lacking a basic region were isolated from a pcD2 cDNA expression library prepared from TIG-3 human diploid fibroblasts (HDF). Of these cDNAs (Id-1H, Id-1H', and Id-2H), two (Id-1H and Id-1H') appeared to be derived by alternative RNA splicing. Id-1H and Id-2H seem to be human homologues of mouse Id-1 and Id-2, respectively, and have potential to encode 154 and 135 amino acid proteins. The Id-1H and Id-2H mRNAs were barely detectable in quiescent early passage HDF; serum coordinately induced both mRNAs, with two peaks of expression, in early and late in G1. Antisense oligomers complementary to Id-1H and Id-2H mRNA prevented early passage HDF from entering the S phase of the cell cycle. The treatment of serum-stimulated early passage cells with the antisense Id-1H oligomer completely abolished Id-1H. In senescent cells, serum barely induced the Id-1H and Id-2H mRNAs, although the levels of c-myc expression induced were similar in early passage and senescent cells. The expression levels of these Id genes vary among immortal human cell lines. Both genes were overexpressed in VA4 SV40-transformed lung fibroblasts and EJ-1 bladder carcinoma cells, while these genes were expressed at a very low level in SVts8 cells derived from SV40 tsA-transformed TIG-3 cells. SVts8 cells may acquire some function redundant to Id proteins. HT1080 fibrosarcoma cells expressed the Id-1H gene but not the Id-2H gene, suggesting these Id genes may subserve redundant functions. PMID:8294468

Hara, E; Yamaguchi, T; Nojima, H; Ide, T; Campisi, J; Okayama, H; Oda, K

1994-01-21

356

SmartID: a highly accurate physics-based isotope attribution algorithm  

NASA Astrophysics Data System (ADS)

The spectral post-processing algorithm Advanced Synthetically Enhanced Detector Resolution Algorithm (ASEDRA (patent pending)) has shown to be a powerful tool for deconvolving full energy peaks from scintillation spectrometeracquired gamma-ray spectra, effectively improving obtainable data-synthesized energy resolutions by a factor of four to six times over what is rendered from the detector. An isotope attribution algorithm, SmartID, was developed to augment ASEDRA in order to improve radionuclide identification accuracy. SmartID utilizes a novel, physics-based method of importance weighting the ASEDRA-identified peaks and the emissions of a candidate isotope. This methodology enhances the screening of potential false peaks and prevents isotope mismatches. As a final step, SmartID assigns a physical matching attribution score to each possible isotope match to reflect goodness-of-fit. A test suite of 105 gammaray spectra acquired with a 2"×2" NaI:Tl spectrometer under varying shielding conditions and various single and multisource configurations were recorded for testing the accuracy of ASEDRA+SmartID. The sources utilized in the tests included 133Ba, 109Cd, 57Co, 60Co, 137Cs, 152Eu, 54Mn, 22Na, 232Th, natural uranium rods and a PuBe source. Shielding configurations varied widely, ranging from none to more than 2.5cm Pb. Overall, SmartID proved to be more than 95% accurate in attributing the correct isotope(s) to the spectra.

Harrison, M. J.; Sjoden, G. E.; Detwiler, R.

2010-04-01

357

Inhibitor of DNA binding 1 (Id1) induces differentiation and proliferation of mouse embryonic carcinoma P19CL6 cells  

SciTech Connect

Highlights: {yields} Id1 was upregulated during the cardiac differentiation process of P19CL6 cells. {yields} Id1 upregulated expression of cardiac specific genes Gata4, {alpha}-MHC and ISL1. {yields} Id1 promoted proliferation of P19CL6 cells. {yields} Overexpression of Id1 increased activity of TOP flash. {yields} Wnt3a or LiCl treatment promoted Id1 expression in P19CL6 cells. -- Abstract: The inhibitor of DNA binding (Id) family of genes encodes negative regulators of basic helix-loop-helix transcription factors and has been implicated in such diverse cellular processes as differentiation, proliferation, apoptosis and migration. Id knockout mouse embryos display multiple cardiac defects but the specific role of Id1 in cardiac differentiation is unclear. In the present study, we investigated the function of Id1 in DMSO-induced P19CL6 cells, a widely-accepted cell model of cardiac differentiation. We found that Id1 was upregulated during the cardiac differentiation of P19CL6 cells. The expression of cardiac specific marker genes, Gata4, {alpha}-MHC and ISL1, was upregulated in P19CL6 cells stably transfected with Id1 (P19CL6-Id1) during cardiac differentiation. The overexpression of Id1 reduced the number of cells in G1 phase and increased the cell population in G2, M and S phases, while knockdown of Id1 increased the number of cells in G1 phase from 48.6 {+-} 2.51% to 62.2 {+-} 1.52% at day 0 of cardiac induction, and from 52.5 {+-} 3.41% to 63.7 {+-} 1.02% at day 3 after cardiac induction, indicating that Id1 promoted proliferation of P19CL6 cells. Luciferase assays showed that the activity of TOP flash was higher in P19CL6-Id1 cells than wildtype P19CL6 cells, while Id1 expression was also upregulated in P19CL6 cells treated with Wnt3a or LiCl. This indicates that there may be positive feedback between Id1 and Wnt signaling which plays an important role in cardiac differentiation.

Meng, Qingzhen; Jia, Zhuqing; Wang, Weiping; Li, Binhong; Ma, Kangtao [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, 38 Xueyuan Road, 100191 Beijing (China)] [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, 38 Xueyuan Road, 100191 Beijing (China); Zhou, Chunyan, E-mail: chunyanzhou@bjmu.edu.cn [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, 38 Xueyuan Road, 100191 Beijing (China)] [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, 38 Xueyuan Road, 100191 Beijing (China)

2011-08-26

358

76 FR 9640 - Prevailing Rate Systems: Santa Clara, CA, Tulsa County, OK, and Angelina County, TX  

Federal Register 2010, 2011, 2012, 2013

...Systems: Santa Clara, CA, Tulsa County, OK, and Angelina County, TX AGENCY: U...an area of application to the Oklahoma, OK, nonappropriated fund (NAF) Federal Wage...an area of application to the Oklahoma, OK, nonappropriated fund (NAF) Federal...

2011-02-22

359

75 FR 45557 - Prevailing Rate Systems; Definition of Tulsa County, OK, and Angelina County, TX, to...  

Federal Register 2010, 2011, 2012, 2013

...Rate Systems; Definition of Tulsa County, OK, and Angelina County, TX, to Nonappropriated...an area of application to the Oklahoma, OK, nonappropriated fund (NAF) Federal Wage...an area of application to the Oklahoma, OK, nonappropriated fund (NAF) Federal...

2010-08-03

360

Drainage basins in St. Johns County, Florida  

USGS Publications Warehouse

The highest point in St. Johns County, Florida is only slightly above 65 feet above sea level and drainage divides are indistinct and readily influenced by cultural features. This report delineates some 80 drainage basins (or artificial equivalents to natural basins such as the Intracoastal Waterway) within the county and their areas in square miles. Total area of St. Johns County is about 670 square miles. (USGS)

Foose, Donald W.

1984-01-01

361

Id1 enhances RING1b E3 ubiquitin ligase activity through the Mel-18/Bmi-1 polycomb group complex.  

PubMed

The helix-loop-helix inhibitor of differentiation and DNA binding (Id1) is well known as an oncogene in various tumors. Although it has been reported that Id1 promotes several oncogenic processes, it is still unclear whether Id1 functions through epigenetic transcriptional regulation. In this study, we examined the effect of Id1 on polycomb group (PcG) proteins, which are crucial epigenetic gene silencers, and found that Id1 regulated the expression of Mel-18 and Bmi-1, both of which belong to polycomb repressive complex 1. We also confirmed that Id1 induced Mel-18 downregulation, which was mediated by the Akt pathway, and consequently upregulated the transcription of its target gene, c-Myc. Using a promoter-reporter, we demonstrated that Id1 regulated Bmi-1 transcription through c-Myc binding to its E-box in the promoter. Finally, we examined the activity of E3 ligase RING1b, whose catalytic activity is increased by binding with the RING finger protein Bmi-1, and found that Id1 overexpression enhanced RING1b E3 ligase activity leading to accumulation of H2A ubiquitination and ubiquitin/proteasome-mediated degradation of geminin. Taken together, our study provided a novel link between Id1 and PcG proteins and suggested that Id1 may contribute to tumor development through PcG-mediated epigenetic regulation. PMID:20697353

Qian, T; Lee, J-Y; Park, J-H; Kim, H-J; Kong, G

2010-10-28

362

Id4 Promotes Senescence and Sensitivity to Doxorubicin-induced Apoptosis in DU145 Prostate Cancer Cells  

PubMed Central

Inhibitor of differentiation proteins (Id1, 2, 3 and 4) are dominant negative regulators of basic helix loop helix transcription factors and play dominant roles in cancer cells, spanning several molecular pathways including senescence, invasion, metastasis, proliferation and apoptosis. In contrast to high Id1, Id2 and Id3 expression, the expression of Id4 is epigenetically silenced in prostate cancer. In the present study we demonstrated a novel role of Id4, that of promotion of cellular senescence in prostate cancer cells. Materials and Methods: Id4 was ectopically expressed in DU145 cells (DU145+Id4). The cells treated with Doxorubicin (0–500 nm) or vehicle control were analyzed for apoptosis, senescence (SA-beta Galactosidase), and expression of CDKN1A (p21), CDKN1B(p27), CDKN2A (p16), E2F1, vimentin and E-cadherin by immuno-histochemistry and/or Western blot. Results: In the present study we demonstrated that Id4 promotes cellular senescence in prostate cancer cell line DU145. Ectopic overexpression of Id4 in androgen receptor-negative DU145 prostate cancer cells resulted in increased expression of p16, p21, p27, E-cadherin and vimentin but down-regulated E2F1 expression. Id4 also potentiated the effect of doxorubicin induced senescence and apoptosis. Conclusion: The absence of functional p16, pRB and p53 in DU145 suggests that Id4 could alter additional molecular pathways such as those involving E2F1 to promote senescence and increased sensitivity to doxorubicin-induced apoptosis. The results of the present study support the role of Id4 as a tumor suppressor in prostate cancer.

Carey, Jason P.; Knowell, Ashley Evans; Chinaranagari, Swathi; Chaudhary, Jaideep

2014-01-01

363

National Dam Inspection Program. Freethy Dam (NDI ID Number PA-00171, DER ID Number 64-160), Delaware River Basin, Carley Brook, Wayne County, Pennsylvania. Phase I Inspection Report.  

National Technical Information Service (NTIS)

Based on the criteria established for these studies, Freethy Dam is judged to be unsafe, nonemergency, because the spillway capacity is seriously inadequate. The recommended Spillway Design Flood (SDF) for the size and hazard classification of the dam var...

F. Futchko

1981-01-01

364

National Dam Inspection Program. Wildwood Lake Dam (NDI ID Number PA-00157, DER ID Number 64-30), Delaware River Basin, Ariel Creek, Wayne County, Pennsylvania. Phase I inspection report.  

National Technical Information Service (NTIS)

Based on visual inspection, available records, calculations, past operational performance, and according to criteria established for these studies, Wildwood Lake Dam is judged to be in fair condition. Based on the size and hazard classification of the dam...

F. Futchko

1981-01-01

365

National Dam Inspection Program. Pike Township Municipal Authority Dam (NDS-ID-PA-00916, PennDER ID-17-111), Susquehanna River Basin, Bear Run, Clearfield County, Pennsylvania. Phase I Inspection Report.  

National Technical Information Service (NTIS)

Bear Run Dam is an earth embankment approximately 42 feet high and 415 feet long (including spillway). The dam is provided with an unlined trapezoidal channel spillway cut into the left abutment. The spillway contains a short concrete control slab adjacen...

B. M. Mihalcin

1979-01-01

366

National Dam Inspection Program. Larsen Dam (NDI ID Number PA-00367, DER ID Number 35-30), Delaware River Basin, Lehigh River, Lackawanna and Wayne Counties, Pennsylvania. Phase I Inspection Report.  

National Technical Information Service (NTIS)

Based on visual inspection, available records, calculations, past operational performance, and according to criteria established for these studies, Larsen Dam is judged to be in fair condition. Based on the size and hazard classification of the dam, the S...

F. Futchko

1981-01-01

367

National Dam Inspection Program. Mill Water Dam (NDS I.D. Number PA 00703, DER I.D. Number 6-442), Susquehanna River Basin, Back Creek, Berks County, Pennsylvania. Phase I Inspection Report.  

National Technical Information Service (NTIS)

Mill Water Pond Dam is owned by the Bethlehem Mines Corporation. The dam was originally built as an industrial water supply dam for the Grace Mine. As the mine is no longer in operation, water from the reservoir is no longer used. The dam and its appurten...

M. F. Beck J. H. Frederick

1980-01-01

368

ID-Based Authenticated Group Key Agreement Secure against Insider Attacks  

NASA Astrophysics Data System (ADS)

In 2004, Choi et al. proposed an ID-based authenticated group key agreement. Unfortunately, their protocol was found to be vulnerable to the insider attacks by Zhang, Chen and Shim. To prevent insider attacks, Shim presented a modification of Choi et al.'s protocol. In this letter, we first show that Shim's modification is still insecure against insider attacks. We then present a modification of Choi et al.'s protocol that resists insider attacks. The counter-measure uses an ID-based signature on transcripts in order to bind them in a session. This prevents any replay of transcripts. Especially, by applying ID-based batch verification, the proposed one still consists of two rounds and is computationally efficient.

Choi, Kyu Young; Hwang, Jung Yeon; Lee, Dong Hoon

369

Tunneling conductance in topological insulator ferromagnet/d+id mixed wave superconductor junctions  

NASA Astrophysics Data System (ADS)

The tunneling conductance in a topological insulator (TI) ferromagnet/d+id mixed wave superconductor (FM/d+id S) junction is studied based on the Blonder-Tinkham-Klapwijk (BTK) theory. It is demonstrated that the conductance strongly depends on the magnetic gap, the superconducting pair symmetry orientation, and the magnitude of the ratio of ?2/?1. Here ?1(?2) is the absolute pair potential of d(d) component. For a large magnetic gap, the tunneling spectrum is characterized by a dip structure. When ?=0.25?, the conductance dip appears at eV=±?2. Thus, the d+id pairing symmetry as well as the magnitude of the gap can be determined from the experiment of scanning tunneling spectroscopy.

Li, Hong; Yang, Xinjian; Jia, Cuiping

2014-05-01

370

Use of ChromID Extended-Spectrum ?-Lactamase Medium for Detecting Carbapenemase-Producing Enterobacteriaceae?  

PubMed Central

ChromID extended-spectrum ?-lactamase (ESBL) culture medium is routinely used for screening ESBL producers. This medium was tested for detecting carbapenemase-producing Enterobacteriaceae isolates from a collection of reference strains and compared to the CHROMagar KPC culture medium previously evaluated for detecting KPC-producing isolates. Producers of IMP-, VIM-, and KPC-type carbapenemases with high levels of resistance to cephalosporins and to carbapenems were detected at 1 × 101 CFU/ml. The OXA-48 producers were not detected on ChromID ESBL medium unless coexpressing ESBLs, whereas carbapenemase-producing isolates with MICs of <4 ?g/ml were not detected on CHROMagar KPC medium.

Carrer, Amelie; Fortineau, Nicolas; Nordmann, Patrice

2010-01-01

371

Surface And Interface Studies At APS Endstation 5ID-C  

NASA Astrophysics Data System (ADS)

We have instrumented the 5ID-C hutch of DND-CAT at the Advanced Photon Source (APS) for x-ray surface spectroscopy and scattering. A wide variety of experiments have already been carried out at 5ID-C, including studies on semiconductors, oxides, metals, nanodots, and biomolecular adsorption. We describe the beamline optics, data collection hardware and software, and both diffractometers, a five-circle kappa diffractometer for open-air and liquid-cell experiments, and a psi-circle diffractometer with an integrated ultrahigh vacuum (UHV) chamber, paying particular attention to the requirements of an XSW measurement.

Walko, D. A.; Sakata, O.; Lyman, P. F.; Lee, T.-L.; Tinkham, B. P.; Okasinski, J. S.; Zhang, Z.; Bedzyk, M. J.

2004-05-01

372

Attitudes of Israeli Teachers and Paraprofessionals towards the New Definition of ID and Their Willingness to Cope with Special Education Law Changes  

ERIC Educational Resources Information Center

Attitudes of teachers (N = 96) and paraprofessionals (N = 48) working with students with intellectual disability (ID) towards the new definition of ID (Luckasson et al., 1992, 2002), was examined. The main innovation of the new definition of ID is the cancellation of the four ID levels, suggesting an optimistic view, especially towards individuals…

Lifshitz, Hefziba; Nissim, Shoshanna; Cohen, Sara

2008-01-01

373

75 FR 49886 - Big Horn County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Big Horn County Resource Advisory Committee...SUMMARY: The Big Horn County Resource Advisory Committee...ADDRESSES: The meeting will be held at the Big Horn County Courthouse, Commissioners...

2010-08-16

374

77 FR 49779 - Big Horn County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Big Horn County Resource Advisory Committee...SUMMARY: The Big Horn County Resource Advisory Committee...ADDRESSES: The meeting will be held at the Big Horn County Weed and Pest Building,...

2012-08-17

375

78 FR 33326 - Big Horn County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Big Horn County Resource Advisory Committee...SUMMARY: The Big Horn County Resource Advisory Committee...ADDRESSES: The meeting will be held at Big Horn County Weed and Pest Building,...

2013-06-04

376

75 FR 71069 - Big Horn County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Big Horn County Resource Advisory Committee...SUMMARY: The Big Horn County Resource Advisory Committee...ADDRESSES: The meeting will be held at the Big Horn County Weed and Pest Building,...

2010-11-22

377

76 FR 47141 - Big Horn County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Big Horn County Resource Advisory Committee...SUMMARY: The Big Horn County Resource Advisory Committee...ADDRESSES: The meeting will be held at the Big Horn County Weed and Pest Building,...

2011-08-04

378

76 FR 26240 - Big Horn County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Big Horn County Resource Advisory Committee...SUMMARY: The Big Horn County Resource Advisory Committee...ADDRESSES: The meeting will be held at the Big Horn County Weed and Pest Building,...

2011-05-06

379

76 FR 12316 - Madera County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Madera County Resource Advisory Committee AGENCY...SUMMARY: The Madera County Resource Advisory Committee will...for expenditure of Payments to States Madera County Title II funds. DATES: The...

2011-03-07

380

76 FR 29722 - Madera County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Madera County Resource Advisory Committee AGENCY...SUMMARY: The Madera County Resource Advisory Committee will...for expenditure of Payments to States Madera County Title II funds. DATES: The...

2011-05-23

381

76 FR 66033 - Madera County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Madera County Resource Advisory Committee AGENCY...SUMMARY: The Madera County Resource Advisory Committee will...for expenditure of Payments to States Madera County Title II funds. DATES: The...

2011-10-25

382

76 FR 6116 - Madera County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Madera County Resource Advisory Committee AGENCY...SUMMARY: The Madera County Resource Advisory Committee will...for expenditure of Payments to States Madera County Title II funds. DATES: The...

2011-02-03

383

76 FR 19970 - Madera County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Madera County Resource Advisory Committee AGENCY...SUMMARY: The Madera County Resource Advisory Committee will...responsibilities for the remainder of the year. The Madera County Resource Advisory Committee...

2011-04-11

384

75 FR 79334 - Madera County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Madera County Resource Advisory Committee AGENCY...SUMMARY: The Madera County Resource Advisory Committee will...for expenditure of Payments to States Madera County Title II funds. The Madera...

2010-12-20

385

75 FR 50987 - Madera County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Madera County Resource Advisory Committee AGENCY...SUMMARY: The Madera County Resource Advisory Committee will...for expenditure of Payments to States Madera County Title II funds. DATES: The...

2010-08-18

386

75 FR 31759 - Madera County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Madera County Resource Advisory Committee AGENCY...SUMMARY: The Madera County Resource Advisory Committee will...Send written comments to Julie Roberts, Madera County Resource Advisory Committee...

2010-06-04

387

State and County Exposure Levels to I-131  

Cancer.gov

State and County Exposure Levels Per capita thyroid doses resulting from all exposure routes from all tests State and County Exposure Levels Per capita thyroid doses resulting from all exposure routes from all tests Next Section > State and County Exposure

388

75 FR 63436 - Glenn/Colusa County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...AGRICULTURE Forest Service Glenn/Colusa County Resource Advisory Committee...SUMMARY: The Glenn/Colusa County Resource Advisory Committee...Designated Federal Official, Glenn/Colusa County RAC Meeting Agenda....

2010-10-15

389

77 FR 56606 - Glenn/Colusa County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...AGRICULTURE Forest Service Glenn/Colusa County Resource Advisory Committee...SUMMARY: The Glenn/Colusa County Resource Advisory Committee...1000&RestrictToCategory=Glenn+and+Colusa+Counties . Anyone who would like...

2012-09-13

390

77 FR 48125 - Glenn/Colusa County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...AGRICULTURE Forest Service Glenn/Colusa County Resource Advisory Committee...SUMMARY: The Glenn/Colusa County Resource Advisory Committee...1000&RestrictToCategory=Glenn+and+Colusa+Counties . Anyone who would like...

2012-08-13

391

6. Photocopy of illustration on Map of Chester County Pennsylvania, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Photocopy of illustration on Map of Chester County Pennsylvania, by T.J. Kennedy, published by R.L. Barnes, Philadelphia, Pennsylvania, 1856 SOUTHWEST CORNER, 1856 - Bank of Chester County, 17 North High Street, West Chester, Chester County, PA

392

75 FR 74681 - Alpine County Resource Advisory Committee (RAC)  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Alpine County Resource Advisory Committee (RAC...SUMMARY: The Alpine County Resource Advisory Committee (RAC...ADDRESSES: The meeting will be held in Alpine County at the Alpine Early Learning...

2010-12-01

393

75 FR 30366 - Alpine County Resource Advisory Committee (RAC)  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Alpine County Resource Advisory Committee (RAC...SUMMARY: The Alpine County Resource Advisory Committee (RAC...6 p.m. The meeting will be held in Alpine County at the Alpine Early Learning...

2010-06-01

394

76 FR 6395 - Alpine County Resource Advisory Committee (RAC)  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Alpine County Resource Advisory Committee (RAC...SUMMARY: The Alpine County Resource Advisory Committee (RAC...ADDRESSES: The meeting will be held in Alpine County at the Alpine Early Learning...

2011-02-04

395

75 FR 52925 - Alpine County Resource Advisory Committee (RAC)  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Alpine County Resource Advisory Committee (RAC...SUMMARY: The Alpine County Resource Advisory Committee (RAC...ADDRESSES: The meeting will be held in Alpine County at the Alpine Early Learning...

2010-08-30

396

75 FR 16069 - Alpine County Resource Advisory Committee (RAC)  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Alpine County Resource Advisory Committee (RAC...SUMMARY: The Alpine County Resource Advisory Committee (RAC...6 p.m. The meeting will be held in Alpine County at the Alpine Early Learning...

2010-03-31

397

76 FR 25299 - Alpine County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF AGRICULTURE Forest Service Alpine County Resource Advisory Committee AGENCY...SUMMARY: The Alpine County Resource Advisory Committee (RAC...ADDRESSES: The meeting will be held in Alpine County at the Alpine Early Learning...

2011-05-04

398

76 FR 61379 - Final Recovery Plan, Bexar County Karst Invertebrates  

Federal Register 2010, 2011, 2012, 2013

...Recovery Plan, Bexar County Karst Invertebrates AGENCY: Fish...for the nine Bexar County Karst Invertebrates under the Endangered...Act. The Act requires the development of recovery plans for listed...following nine Bexar County karst invertebrates were listed...

2011-10-04

399

Effect of Id1 knockdown on formation of osteolytic bone lesions by prostate cancer PC3 cells in vivo.  

PubMed

The formation of osteolytic bone lesions is a key process for osteolytic cancer to metastasize to the bone and is under the control of a set of transcription factors. Recently, the inhibitor of differentiation 1 (Id1) has been linked with angiogenesis, tumorigenesis, metastasis and bone formation. However, the function of Id1 during the process of bone destruction caused by cancer in vivo has not yet been elucidated. We, therefore, examined whether and how Id1 affects the ability of cancer to form osteolytic lesion in vivo. The study used a lentiviral vector overexpressing short hairpin RNA (shRNA) targeting Id1 gene. PC3 cells, a prostate cancer cell line, were transduced with Id1 shRNA or negative control (NC) shRNA before implantation in BALB/c mice. Cells were implanted in a tibial injection model. Tumor formation in bone was monitored by X-ray. The relationship between parathyroid hormone-related protein (PTHrP), an osteolytic factor, and Id1 was analyzed by using immunohistochemistry in tissue sections from osteolytic lesion of the BALB/c mice. Our results showed that Id1 shRNA delivery to PC3 cells by lentivirus caused efficient and stable Id1 gene silencing. In the intratibial model, PC3 cells produced primarily osteolytic lesions in the bone. Eleven of 14 mice in Id1 shRNA group but only 4 of 14 mice in the NC shRNA group developed osteolytic lesions with cortical destruction at 4th week. Mice treated with Id1 shRNA had larger tumor volume in the bone and larger cortical destruction. The expression of PTHrP protein in PC3 cells was not affected by Id1 knockdown in vivo. These results indicate that Id1 may down-regulate the ability of PC3 cells to form osteolytic lesions in vivo and the signal pathway needs to be further investigated. PMID:22684559

Zhang, Zhengguo; Li, Kuanxin; Zhang, Xiaomei; Fang, Zhong; Xiong, Wei; Chen, Qi; Chen, Wenjian; Li, Feng

2012-06-01

400

Purification and characterization of two distinct thermostable lipases from the gram-positive thermophilic bacterium Bacillus thermoleovorans ID1  

Microsoft Academic Search

The thermophilic bacterium Bacillus thermoleovorans ID-1 can hydrolyze a variety of oils such as olive oil, soybean oil, palm oil, and lard as a carbon source (1.5%, v\\/v) after 72 h of culture at 50°C. In this study, we purified to homogeneity two distinct thermostable lipases, designated BTID-A (B. thermoleovorans ID-1 lipase A) and BTID-B (B. thermoleovorans ID-1 lipase B).

Dong-Woo Lee; Hack-Woo Kim; Keun-Wook Lee; Byoung-Chan Kim; Eun-Ah Choe; Han-Seung Lee; Doo-Sik Kim; Yu-Ryang Pyun

2001-01-01

401

Crawford County Adult Education Center Program Evaluation  

ERIC Educational Resources Information Center

The Crawford County Adult Education Program Evaluation was implemented to gather data that would assist in increasing the number of enrolled students at CCAEC. The data were compiled from state, federal, local extant data, a Community Opinion Survey and focus group interviews. Of the 1,015 Crawford County Residents who were emailed the COS, 213…

Faubus, Deborah L.

2011-01-01

402

Geothermal development issues: Recommendations to Deschutes County  

SciTech Connect

This report discusses processes and issues related to geothermal development. It is intended to inform planners and interested individuals in Deschutes County about geothermal energy, and advise County officials as to steps that can be taken in anticipation of resource development. (ACR)

Gebhard, C.

1982-07-01

403

THE VEGETATION OF TRUMBULL COUNTY, OHIO1  

Microsoft Academic Search

THE REGIONAL BACKGROUND Trumbull County is located in northeastern Ohio, adjacent to Pennsylvania. It lies midway between the glacial boundary and Lake Erie, and a single county lies between it and the lake. It is approximately twenty-five miles square. Its subdivisions and principal streams are shown in the accompanying map (Figure 1). The elevation above sea level ranges from 800

ROYAL E. SHANKS; Austin Peay

404

A Profile of Hardee County, Florida.  

ERIC Educational Resources Information Center

In 1977 leaders of Hardee County, Florida, listed relationships and attitudes of residents, rural atmosphere, environmental conditions, and economic potential among the county's strong points, and public service and facility improvements, developing economic potential, recreational and entertainment development, and planning and zoning as its most…

Beaulieu, Lionel J.; Anderson, Deborah S.

405

Youth Political Culture in a Kentucky County.  

ERIC Educational Resources Information Center

Data from a self-administered questionnaire survey of all 188 high school juniors and seniors who attended the only high school in a rural county in Kentucky were utilized to explore various dimensions of youth political culture in that county. The study was part of a continuing effort to understand and analyze the political culture and…

Mohapatra, Manindra Kumar

406

Edgecombe County, n.C. Subdivision Regulations.  

National Technical Information Service (NTIS)

Recent industrial growth and a general increase in residential expansion within the county has created a need for firm land-use controls. The subdivision regulations are intended to act as a guide for the proper subdivision of land in Edgecombe County and...

1970-01-01

407

COUNTY BOUNDARIES FOR THE MAIA STUDY REGION  

EPA Science Inventory

This data set is a geographic information system (GIS) coverage of the county boundaries in the United States Environmental Protection Agency (USEPA) Mid-Atlantic Integrated Assessment (MAIA) Project region. The coverage was produced using the US Geological Survey county bound...

408

Cayuga County Regional Digester. Vision Becomes Reality.  

National Technical Information Service (NTIS)

With an average herd size of 113 mature cows, Cayuga County is home to 280 dairy farms and 31,500 dairy milking cows producing approximately 855 million gallons of milk per year. The Cayuga Dairy industry is a major contributor to the county's economy, em...

J. Young K. V. Zadeh M. Riley S. Huey

2013-01-01

409

A Profile of Suwannee County, Florida.  

ERIC Educational Resources Information Center

Agriculture and the railroad were significant forces in the development of Suwannee County, Florida, formally created in 1858 but explored and settled beginning some 300 years earlier. Lumber and cotton caused an early 20th century boom in the county which soon saw the negative effects of both industries. The introduction of tobacco in the late…

Beaulieu, Lionel J.

410

Educational and Demographic Profile: Alpine County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Alpine County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

411

A Community Needs Assessment: Franklin County, Massachusetts.  

ERIC Educational Resources Information Center

In collaboration with a county hospital and two local government planning offices, Greenfield Community College (GCC) conducted a survey of 1,200 randomly selected residents of Franklin County, Massachusetts, to obtain a demographic profile of area citizens and to identify their needs in the areas of postsecondary education, health care,…

DiCarlo, Robert D.

412

[A Profile of Kershaw County, South Carolina].  

ERIC Educational Resources Information Center

Careful long-range planning and slow, deliberate growth have benefitted Kershaw County's 500,000 pleasantly varied acres near the state capitol. The county, famous for its equestrian activity, boasts prestige stables, riding clubs, and trails. In addition there are lakes and numerous parks. Leaders want to maintain this aesthetic appeal while…

Lilley, Stephen C.; McLean, Edward L.

413

Santa Clara County Asian Health Survey: Methodology.  

ERIC Educational Resources Information Center

This paper describes the methodology used in a study assessing the health needs of the Asian population, specifically the Chinese, Cambodian, and Vietnamese populations, in Santa Clara County, California. The study by the Santa Clara County Health Department is part of a wide-ranging needs assessment project primarily intended to guide…

Tom, Soleng; And Others

414

Analysis of County School Districts in Arkansas.  

ERIC Educational Resources Information Center

The 1948, Arkansas School District Reorganization Act was passed in an effort to reduce the 1589 small school districts to a smaller number. Those districts not consolidated would form county districts. As of the 1967-68 school year, 26 of these county districts remained. The purpose of this study was to provide information drawing attention to…

Budd, Karol B.; Charlton, J.L.

415

Pennsylvania Dutch Country of Lancaster County  

NSDL National Science Digital Library

The Pennsylvania Dutch Convention And Visitors Bureau, in cooperation with the attractions of the Amish Country of Lancaster County, Pennsylvania, now offer a complete virtual information center on the Pennsylvania Dutch Country of Lancaster County. Includes information on the Amish, quilts, covered bridges, and all the interesting things to see and do in the area.

416

Educational and Demographic Profile: Kern County.  

ERIC Educational Resources Information Center

This profile derived from U.S. Census 2000 data presents educational and socioeconomic information for Kern County, California, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for…

California Postsecondary Education Commission, 2004

2004-01-01

417

Educational and Demographic Profile: Solano County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Solano County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. The information provides a framework for enhanced communication and…

California Postsecondary Education Commission, 2004

2004-01-01

418

Educational and Demographic Profile: Yolo County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Yolo County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced communication…

California Postsecondary Education Commission, 2004

2004-01-01

419

Educational and Demographic Profile: Siskiyou County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Siskiyou County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

420

Educational and Demographic Profile: Mono County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Mono County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced communication…

California Postsecondary Education Commission, 2004

2004-01-01

421

Educational and Demographic Profile: Mendocino County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Mendocino County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

422

Educational and Demographic Profile: Imperial County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Imperial County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

423

Educational and Demographic Profile: San Benito County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for San Benito County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

424

Educational and Demographic Profile: Sacramento County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Sacramento County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

425

Educational and Demographic Profile: Monterey County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Monterey County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

426

Educational and Demographic Profile: San Mateo County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for San Mateo County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

427

Educational and Demographic Profile: Trinity County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Trinity County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

428

Educational and Demographic Profile: Napa County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Napa County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced communication…

California Postsecondary Education Commission, 2004

2004-01-01

429

Educational and Demographic Profile: Lake County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Lake County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced communication…

California Postsecondary Education Commission, 2004

2004-01-01

430

Educational and Demographic Profile: Los Angeles County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Los Angeles County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

431

Educational and Demographic Profile: Riverside County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Riverside County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

432

Educational and Demographic Profile: Shasta County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Shasta County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

433

Educational and Demographic Profile: Placer County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Placer County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced communication…

California Postsecondary Education Commission, 2004

2004-01-01

434

Educational and Demographic Profile: Tuolumne County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Tuolumne County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

435

Educational and Demographic Profile: Santa Cruz County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Santa Cruz County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation provides a framework for enhanced communication and…

California Postsecondary Education Commission, 2004

2004-01-01

436

Educational and Demographic Profile: Kings County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Kings County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced communication…

California Postsecondary Education Commission, 2004

2004-01-01

437

Educational and Demographic Profile: Madera County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Madera County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

438

Educational and Demographic Profile: Tehama County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Tehama County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

439

Educational and Demographic Profile: Modoc County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Modoc County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

440

Educational and Demographic Profile: Sonoma County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Sonoma County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. The information provides a framework for enhanced communication and…

California Postsecondary Education Commission, 2004

2004-01-01

441

Educational and Demographic Profile: Tulare County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Tulare County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

442

Educational and Demographic Profile: Merced County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Merced County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced communication…

California Postsecondary Education Commission, 2004

2004-01-01

443

Educational and Demographic Profile: El Dorado County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for El Dorado County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

444

Educational and Demographic Profile: Humboldt County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Humboldt County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

445

Educational and Demographic Profile: Glenn County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Glenn County, California, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

446

Educational and Demographic Profile: Sutter County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Sutter County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

447

Educational and Demographic Profile: San Bernardino County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for San Bernardino County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

448

Educational and Demographic Profile: Inyo County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Inyo County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced communication…

California Postsecondary Education Commission, 2004

2004-01-01

449

Educational and Demographic Profile: Orange County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Orange County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

450

Educational and Demographic Profile: Plumas County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Plumas County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced communication…

California Postsecondary Education Commission, 2004

2004-01-01

451

Educational and Demographic Profile: Fresno County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Fresno County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

452

Educational and Demographic Profile: Ventura County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Ventura County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

Louisiana State Department of Education, 2004

2004-01-01

453

Educational and Demographic Profile: Santa Barbara County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Santa Barbara County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

454

Educational and Demographic Profile: San Joaquin County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for San Joaquin County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

455

Educational and Demographic Profile: San Francisco County  

ERIC Educational Resources Information Center

This profile uniquely presents educational and socioeconomic information for San Francisco County, nearby counties, and the state. It highlights the relationship between various factors that affect the economic well-being of individuals and communities. This information provides a framework for enhanced communication and collaboration between the…

California Postsecondary Education Commission, 2004

2004-01-01

456

Educational and Demographic Profile: Nevada County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Nevada County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

457

Educational and Demographic Profile: Sierra County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Sierra County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

458

Educational and Demographic Profile: Marin County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Marin County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced communication…

California Postsecondary Education Commission, 2004

2004-01-01

459

Educational and Demographic Profile: Stanislaus County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Stanislaus County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

460

Educational and Demographic Profile: Santa Clara County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Santa Clara County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

461

Educational and Demographic Profile: Mariposa County.  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Mariposa County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

462

Educational and Demographic Profile: Lassen County  

ERIC Educational Resources Information Center

This profile uniquely presents a variety of educational and socioeconomic information for Lassen County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

California Postsecondary Education Commission, 2004

2004-01-01

463

Public Library Service for San Benito County.  

ERIC Educational Resources Information Center

A sparsely populated, agricultural area, San Benito County (California) provides library services in conjunction with the Hollister city library and in cooperation with the San Juan Bautista city library. Financing comes from the county general fund. There are no written goals or policy statements and no professionally trained librarians. As…

McGovern, Gail

464

COUNTIES OF CALIFORNIA - WITH FARM STATISTICS  

EPA Science Inventory

County farming statistics polygon coverage of California. The statistics were taken from the 1997 Census of Agriculture and added to a coverage extracted from TIGER county boundaries. A farm is any place from which $1,000 or more of agricultural products were sold, or normally w...

465

Commodity Flow Study - Clark County, Nevada, USA  

SciTech Connect

The United States Department of Energy has designated Clark County, Nevada as an 'Affected Unit of Local Government' due to the potential for impacts by activities associated with the Yucca Mountain High Level Nuclear Waste Repository project. Urban Transit, LLC has led a project team of transportation including experts from the University of Nevada Las Vegas Transportation Research Center to conduct a hazardous materials community flow study along Clark County's rail and truck corridors. In addition, a critical infrastructure analysis has also been carried out in order to assess the potential impacts of transportation within Clark County of high level nuclear waste and spent nuclear fuel to a proposed repository 90 miles away in an adjacent county on the critical infrastructure in Clark County. These studies were designed to obtain information relating to the transportation, identification and routing of hazardous materials through Clark County. Coordinating with the United States Department of Energy, the U.S. Department of Agriculture, the U. S. Federal Highway Administration, the Nevada Department of Transportation, and various other stakeholders, these studies and future research will examine the risk factors along the entire transportation corridor within Clark County and provide a context for understanding the additional vulnerability associated with shipping spent fuel through Clark County. (authors)

Conway, S.Ph.D. [Urban Environmental Research LLC, Las Vegas, NV (United States); Navis, I. [AICP Planning Manager, Clark County Nuclear Waste Division, Department of Comprehensive Planning, Las Vegas, NV (United States)

2008-07-01

466

Environmental assessment: Deaf Smith County site, Texas  

SciTech Connect

In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and the eight other potentially sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of the five sites suitable for characterization. 591 refs., 147 figs., 173 tabs.

Not Available

1986-05-01

467

Water resources of Duval County, Florida  

USGS Publications Warehouse

The report describes the hydrology and water resources of Duval County, the development of its water supplies, and water use within the county. Also included are descriptions of various natural features of the county (such as topography and geology), an explanation of the hydrologic cycle, and an interpretation of the relationship between them. Ground-water and surface-water resources and principal water-quality features within the county are also discussed. The report is intended to provide the general public with an overview of the water resources Of Duval County, and to increase public awareness of water issues. Information is presented in nontechnical language to enable the general reader to understand facts about water as a part of nature, and the problems associated with its development and use.

Phelps, G. G.

1994-01-01

468

EAST SIDE, LOCATED WEST OF THE MONTGOMERY COUNTY COURTHOUSE ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

EAST SIDE, LOCATED WEST OF THE MONTGOMERY COUNTY COURTHOUSE - U. S. Post Office, Courthouse Station, South Washington Street & West Montgomery Avenue on Courthouse Square, Rockville, Montgomery County, MD

469

7. Photocopy of photograph (from Broome County Historical Society) showing ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photocopy of photograph (from Broome County Historical Society) showing SWIMMERS, PHOTOGRAPH TAKEN FACING NORTHEAST - Charles F. Johnson Pool, Charles F. Johnson Park, Johnson City, Broome County, NY

470

Shoreham Railroad Bridge, Former Addison County Railroad (later, Rutland Railroad, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Shoreham Railroad Bridge, Former Addison County Railroad (later, Rutland Railroad, Addison Branch), spanning Lemon Fair River above Richville Pond, west of East Shoreham Road, Shoreham, Addison County, VT

471

Geologic Investigations Near an Underhand Cut-and-Fill Stope, Lucky Friday Mine, Mullan, ID.  

National Technical Information Service (NTIS)

Researchers from the U.S. Bureau of Mines conducted geologic investigations in an area of the Lucky Friday Mine, Mullan, ID, that included the 5300-107 demonstration stope using underhand longwall cut-and-fill mining. Structural analysis of the area sugge...

D. F. Scott

1993-01-01

472

MAD-IDS: Novel Intrusion Detection System Using Mobile Agents and Data Mining Approaches  

Microsoft Academic Search

Intrusion Detection has been investigated for many years and the field reached the maturity. Nevertheless, there are still important challenges, e.g., how an Intrusion Detection System (IDS) can detect new and complex distributed at- tacks. To tackle this problem, we propose a novel distributed intrusion detection system, based on the desirable features provided by the mobile agent methodol- ogy. Our

Imen Brahmi; Sadok Ben Yahia; Pascal Poncelet

2010-01-01

473

Ubiquitous ID: Standards for Ubiquitous Computing and the Internet of Things  

Microsoft Academic Search

In ubiquitous computing environments, many tiny computers cooperate, adapting their behaviors according to real-world contexts to provide flexible information services. These information services can't be realized without technology standardization in a broad area. In this article, we discuss the principle of ubiquitous computing technology standardization and introduce uID standards currently in development.

Noboru Koshizuka; Ken Sakamura

2010-01-01

474

A Provably Secure Revocable ID-Based Authenticated Group Key Exchange Protocol with Identifying Malicious Participants  

PubMed Central

The existence of malicious participants is a major threat for authenticated group key exchange (AGKE) protocols. Typically, there are two detecting ways (passive and active) to resist malicious participants in AGKE protocols. In 2012, the revocable identity- (ID-) based public key system (R-IDPKS) was proposed to solve the revocation problem in the ID-based public key system (IDPKS). Afterwards, based on the R-IDPKS, Wu et al. proposed a revocable ID-based AGKE (RID-AGKE) protocol, which adopted a passive detecting way to resist malicious participants. However, it needs three rounds and cannot identify malicious participants. In this paper, we fuse a noninteractive confirmed computation technique to propose the first two-round RID-AGKE protocol with identifying malicious participants, which is an active detecting way. We demonstrate that our protocol is a provably secure AGKE protocol with forward secrecy and can identify malicious participants. When compared with the recently proposed ID/RID-AGKE protocols, our protocol possesses better performance and more robust security properties.

Tsai, Tung-Tso

2014-01-01

475

Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis  

PubMed Central

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), a malignancy commonly found in AIDS patients. Whether KS is a true neoplasm or hyperplasia has been a subject of intensive debate until recently when KSHV is unequivocally shown to efficiently infect, immortalize and transform rat primary mesenchymal precursor cells (MM). Moreover, KSHV-transformed MM cells (KMM) efficiently induce tumors with hallmark features of KS when inoculated into nude mice. Here, we showed Smad1 as a novel binding protein of KSHV latency-associated nuclear antigen (LANA). LANA interacted with and sustained BMP-activated p-Smad1 in the nucleus and enhanced its loading on the Id promoters. As a result, Ids were significantly up-regulated in KMM cells and abundantly expressed in human KS lesions. Strikingly, genetic and chemical inhibition of the BMP-Smad1-Id pathway blocked the oncogenic phenotype of KSHV-transformed cells in vitro and in vivo. These findings illustrate a novel mechanism by which a tumor virus hijacks and converts a developmental pathway into an indispensable oncogenic pathway for tumorigenesis. Importantly, our results demonstrate the efficacy of targeting the BMP-Smad1-Id pathway for inhibiting the growth of KSHV-induced tumors, and therefore identify the BMP pathway as a promising therapeutic target for KS.

Li, Shasha; Dong, Jiazhen; Wang, Xing; Wang, Yuhan; He, Li; He, Zhiheng; Gao, Yuan; Gao, Shou-Jiang; Lan, Ke

2014-01-01

476

Infrastructures and Middleware for the Application of eID Cards in eGovernment  

NASA Astrophysics Data System (ADS)

Cross border eID interoperability is one of the main goals to meet the pan-European challenge. At the same time appropriate conformance to any requirements of flexibility, legal certainty as the case may be guaranteed future will be stipulated.

Walloschke, Thomas

477

A Study on Noise Tolerance of the IDS Method in Regression  

Microsoft Academic Search

The ink drop spread (IDS) method is a modeling technique that provides several advantages with regard to real- time capabilities, tractability, and interpretability of models; thus, it has a good potential to be a useful soft computing tool. Robustness is one of the criteria that determine the effectiveness of a soft computing approach. This paper deals with the noise tolerance

Masayuki Murakami; Nakaji Honda

2006-01-01

478

FAST-id system for enrichment of cells with TALEN-induced mutations and large deletions.  

PubMed

Transcription activator-like effector nuclease (TALEN)-mediated genome editing is a powerful technique for analyzing gene functions in various cells and organisms. At target loci, TALENs can not only introduce short insertions and deletions, but also yield large deletions through the use of two TALEN pairs. Here, we report easy and efficient methods for enrichment of cells with TALEN-induced mutations and large deletions. First, we established the fluorescence-activated sorting of TALEN-induced deletions (FAST-id) system that enabled fluorescence-activated cell sorting-mediated enrichment of cells with TALEN-induced mutations. In the FAST-id system, either EGFP or mCherry and TALENs were co-expressed. Using dual fluorescence selection, both left and right TALEN-expressing cells were easily concentrated, resulting in enrichment of TALEN-mediated mutated cells. Next, to apply the FAST-id system to enrichment of cells with large deletions, we developed the fast unification of separate endonucleases (FUSE) method for assembly of two TALENs into a single expression vector. Using the FUSE method, we easily obtained a TALEN pair-expressing plasmid driven by a single promoter. By combining the FAST-id system and FUSE method, cells with large deletions were efficiently enriched. To the best of our knowledge, this is the first report of enrichment of cells with TALEN-induced large deletions. PMID:24636012

Tokumasu, Daisuke; Sakuma, Tetsushi; Hayashi, Yoko; Hosoi, Sayaka; Hiyama, Eiso; Yamamoto, Takashi

2014-05-01

479

77 FR 50417 - Proposed Amendment of Class D and Class E Airspace; Lewiston, ID  

Federal Register 2010, 2011, 2012, 2013

...12-ANM-9] Proposed Amendment of Class D and Class E Airspace; Lewiston, ID AGENCY...The NPRM proposed a modification of Class D airspace, and Class E airspace extending...the FAA published a NPRM to modify Class D airspace, and Class E airspace...

2012-08-21

480

Preparation of idli batter, its properties and nutritional improvement during fermentation.  

PubMed

Idli is a traditional fermented rice and black gram based food. Idli batter is prepared by soaking polished parboiled rice and decorticated black gram for 4 h at 30?±?1 °C in water. The soaked mass was ground using a grinder with adequate amount of water. The blend ratios of 2:1, 3:1 and 4:1 (w/w) batter were allowed for fermentation for different periods with the addition of 2% (w/w) of salt. The rheology of the product was assessed using a Brookfield Viscometer having disc spindles. Shear stress values were in the range of 0.22 and 4 Pa and reached a maximum value at 7 h of fermentation. The density, pH, and percentage total acidity of batter during fermentation for different blend ratios ranged between 0.93 and 0.59 gm cm(-3), 4.21 and 5.9 and 0.44 and 0.91% respectively. During fermentation, maximum production of riboflavin and thiamine were found to be 0.76 mg/100 gm and 0.73 mg/100 gm in 3:1 blend ratio of idli batter; and the folic acid content was found to be at a maximum of 0.75 mg/100 gm of idli batter after 10 h of fermentation. Digestibility in terms of amino N2 content was analysed by formol titration. PMID:23572795

Ghosh, Debasree; Chattopadhyay, Parimal

2011-10-01

481

Integrating Automatic Data Acquisition with Business Processes - Experiences with SAP's AutoID Infrastructure  

Microsoft Academic Search

Smart item technologies, like RFID and sensor networks, are considered to be the next big step in business process automation (1). Through automatic and real-time data acquisition, these technologies can benefit a great variety of industries by improving the efficiency of their operations. SAP's Auto-ID infrastructure enables the integration of RFID and sensor technologies with existing business processes. In this

Christof Bornhövd; Tao Lin; Stephan Haller; Joachim Schaper

2004-01-01

482

Id1 stimulates cell proliferation through activation of EGFR in ovarian cancer cells  

Microsoft Academic Search

Increased EGFR (epidermal growth factor receptor) expression has been reported in many types of human cancer and its levels are positively associated with advanced cancers. Recently, upregulation of Id-1 (inhibitor of differentiation or DNA binding) protein was found in over 70% of ovarian cancer samples and correlated with poor survival of ovarian cancer patients. However, the molecular mechanisms responsible for

X Zhang; M-T Ling; H Feng; Y C Wong; S W Tsao; X Wang

2004-01-01

483

Evaluation of optical security features in ID documents, currency, and stamps  

NASA Astrophysics Data System (ADS)

Optical security features have been increasingly used to protect and ensure the integrity of value documents. The types of optical features and their purposes are discussed. The application of these optical features to ID documents, currency and postage stamps are discussed. Particular attention is paid to the fraud and counterfeit resistance of the features in relation to the specific document.

Mercer, John W.

2002-04-01

484

76 FR 23321 - New Sweden Irrigation District, ID; Notice of Preliminary Permit Application Accepted for Filing...  

Federal Register 2010, 2011, 2012, 2013

...Project No. 14126-000] New Sweden Irrigation District, ID; Notice of Preliminary...Applications On March 29, 2011, New Sweden Irrigation District filed an application for a...annual generation of the New Sweden Irrigation Project would be 5.6...

2011-04-26

485

ID4 methylation predicts high risk of leukemic transformation in patients with myelodysplastic syndrome  

Microsoft Academic Search

Epigenetic gene silencing due to promoter methylation is observed in human cancers like acute myeloid leukemia (AML). Little is known about aberrant methylation in myelodysplastic syndrome (MDS), a heterogeneous clonal stem cell disorder with a ?30% risk of transformation into secondary AML. Recent evidence demonstrated that ID4, a negative regulator of transcription, may act as a tumor-suppressor gene. To clarify

Hong Wang; Xiao-Qin Wang; Xiao-Ping Xu; Guo-Wei Lin

2010-01-01

486

Developing Technical Expertise in Secondary Technical Schools: The Effect of 4C/ID Learning Environments  

ERIC Educational Resources Information Center

In this study, the effectiveness of learning environments, developed in line with the specifications of the four components instructional design model (4C/ID model) and the additional effect of ICT for fostering the development of technical expertise in traditional Ghanaian classrooms, was assessed. The study had a one-by-one-by-two…

Sarfo, Frederick K.; Elen, Jan

2007-01-01

487

M2D2: A Formal Data Model for IDS Alert Correlation  

Microsoft Academic Search

At present, alert correlation techniques do not make full use of the information that is available. We propose a data model for IDS alert correlation called M2D2. It supplies four information types: in- formation related to the characteristics of the monitored information system, information about the vulnerabilities, information about the se- curity tools used for the monitoring, and information about

Benjamin Morin; Mé Ludovic; Hervé Debar; Mireille Ducassé

2002-01-01

488

People Tracking with Anonymous and ID-Sensors Using Rao-Blackwellised Particle Filters  

Microsoft Academic Search

Estimating the location of people using a network of sensors placed throughout an environment is a fundamental challenge in smart environments and ubiquitous computing. Id-sensors such as infrared badges provide explicit object identity information but coarse location information while anonymous sensors such as laser range-finders provide accurate location information only. Tracking using both sen- sor types simultaneously is an open

Dirk Schulz; Dieter Fox; Jeffrey Hightower

2003-01-01

489

Developing cyberspace data understanding: using CRISP-DM for host-based IDS feature mining  

Microsoft Academic Search

Current intrusion detection systems (IDS) generate a large number of specific alerts, but typically do not provide actionable information. Compounding this problem is the fact that many alerts are false positive alerts. This paper applies the Cross Industry Standard Process for Data Mining (CRISP-DM) to develop an understanding of a host environment under attack. Data is generated by launching scans

Joseph R. Erskine; Gilbert L. Peterson; Barry E. Mullins; Michael R. Grimaila

2010-01-01

490

Evaluation of CPS ID 2 chromogenic agar as a single medium for urine culture  

Microsoft Academic Search

The CPS ID 2 (CPS) chromogenic agar was compared to routine media for use in the isolation, enumeration, identification, and susceptibility testing of bacteria recovered from urine specimens. Of 487 urine specimens, 318 were culture negative, 12 were positive on CPS only, 16 positive on routine only, and 141 positive on both. The enumeration of microorganisms agreed for 96 of

Barbara S. Reisner; Ellen F. Austin

1997-01-01

491

Identification of clinical yeasts by Vitek MS system compared with API ID 32 C.  

PubMed

We performed a clinical evaluation of the Vitek MS matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) system with the commercial database version 2.0 for rapid identification of medically important yeasts as compared with the conventional phenotypic method API ID 32 C. We tested 161 clinical isolates, nine isolates from culture collections and five reference strains. In case of discrepant results or no identification with one or both methods, molecular identification techniques were employed. Concordance between both methods was observed with 160/175 isolates (91.42%) and misidentifications by both systems occurred only when taxa were not included in the respective databases, i.e., one isolate of Candida etchellsii was identified as C. globosa by Vitek MS and two isolates of C. orthopsilosis were identified as C. parapsilosis by API ID 32 C. Vitek MS could not identify nine strains (5.14%) and API ID 32 C did not identify 13 (7.42%). Vitek MS was more reliable than API ID 32 C and reduced the time required for the identification of clinical isolates to only a few minutes. PMID:24782106

Durán-Valle, M Teresa; Sanz-Rodríguez, Nuria; Muñoz-Paraíso, Carmen; Almagro-Moltó, María; Gómez-Garcés, José Luis

2014-05-01

492

An Infrastructural Approach to Secure Interoperability of Electronic IDs: The Bridging Backbone  

Microsoft Academic Search

In this paper we propose a solution to secure interoperability between electronic ID management infrastructures enabling the provision of cross-border eServices to mobile citizens. Our proposal considers an interoperability architec- ture based on a federation of national infrastructures and follows a cooperation based approach which is fully compatible with and respectful of organizational and technical independence of existing national systems.

Franco Arcieri; Andrea Dimitri; Fabio Fioravanti; Enrico Nardelli; Katia Pallucca; Alberto Postiglione; Maurizio Talamo

2005-01-01

493

Extraction of words from the national ID cards for automated recognition  

NASA Astrophysics Data System (ADS)

The government of Bangladesh introduced national ID cards in 2008 for all peoples of age 18 years and above. This card is now a de-facto identity document and finds diverse applications in vote casting, bank account opening, telephone subscribing as well as in many real life transactions and security checking. To get real fruits of this versatile ID card, automated retrieving and recognition of an independent person from this extra large national database is an ultimate necessity. This work is the first step to fill this gap in making the recognition in automated fashion. Here we have investigated an image analysis technique to extract the words that will be used in subsequent recognition steps. At first scanned ID card image is used as an input into the computer system and then the target text region is separated from the picture region. The text region is used for separation of lines and words on the basis of the vertical and horizontal projections of image intensity, respectively. Experimentation using real national ID cards confirms the effectiveness of our technique.

Akhter, Md. Rezwan; Bhuiyan, Md. Hasanuzzaman; Uddin, Mohammad Shorif

2011-10-01

494

Knox County Black History Archives  

NSDL National Science Digital Library

Knox County, Ohio has had a significant black population for several hundred years, and historians and others have documented their activities in journal articles, books, and other printed materials. This remarkable digital collection from the Digital Resource Commons at Kenyon College provides access to photographs, documents, and other items that tell the story of this unique community. This collection was made possible, in part, by funding from the Ohio Humanities Council, along with support from the Rural Life Center. Currently the collection includes 200 items, which visitors can browse alphabetically or by performing a keyword search. Each item has a preview feature and visitors can click through to zoom in on each item. The handwritten history of Mt. Cavalry Baptist Church is particularly fascinating.

2012-06-01

495

Initial Validation of the Chinese Quality of Life Questionnaire-Intellectual Disabilities (CQOL-ID): A Cultural Perspective  

ERIC Educational Resources Information Center

Background: In the field of intellectual disabilities (ID), the quality of life concept has been developing rapidly in Chinese societies including Hong Kong, mainland China and Taiwan. However, there is a lack of locally validated instruments to measure the quality of life of people with ID. The study reported in this paper attempted to validate…

Wong, P. K. S.; Wong, D. F. K.; Schalock, R. L.; Chou, Y-C.

2011-01-01

496

Inhibitor of DNA Binding 4 (ID4) Regulation of Adipocyte Differentiation and Adipose Tissue Formation in Mice*  

PubMed Central

Inhibitor of DNA binding 4 (ID4) is a helix-loop-helix protein that heterodimerizes with basic helix-loop-helix transcription factors inhibiting their function. ID4 expression is important for adipogenic differentiation of the 3T3-L1 cell line, and inhibition of ID4 is associated with a concomitant decrease in CCAAT/enhancer-binding protein ? and peroxisome proliferator-activated receptor ? mRNA and protein expression. Mice with a homozygous deletion of Id4 (Id4?/?) have reduced body fat and gain much less weight compared with wild-type littermates when placed on diets with high fat content. Mouse embryonic fibroblasts (MEFs) isolated from Id4?/? mice have reduced adipogenic potential when compared with wild-type MEFs. In agreement with changes in morphological differentiation, the levels of CCAAT/enhancer-binding protein ? and peroxisome proliferator-activated receptor ? were also reduced in MEFs from Id4?/? mice. Our results demonstrate the importance of ID4 in adipocyte differentiation and the implications of this regulation for adipose tissue formation.

Murad, Joana M.; Place, Chelsea S.; Ran, Cong; Hekmatyar, Shahryar K. N.; Watson, Nathan P.; Kauppinen, Risto A.; Israel, Mark A.

2010-01-01

497

Tubular cell dedifferentiation and peritubular inflammation are coupled by the transcription regulator Id1 in renal fibrogenesis.  

PubMed

During renal fibrogenesis, tubular epithelial-mesenchymal transition is closely associated with peritubular inflammation; however, it is not clear whether these two processes are connected. We previously identified the inhibitor of differentiation-1 (Id1), a dominant negative antagonist of basic helix-loop-helix transcription factors, as a major trigger of tubular cell dedifferentiation after injury. Id1 was induced selectively in degenerated proximal tubule and collecting duct epithelia after injury and was present in both the cytoplasm and nucleus, suggesting shuttling between these two compartments. Interestingly, the upregulation of Id1 was associated with peritubular inflammation in mouse and human nephropathies. In vitro, Id1 potentiated NF-?B signaling and augmented RANTES expression in kidney epithelial cells, which led to an enhanced recruitment of inflammatory cells. Id1 also induced Snail1 expression and triggered tubular epithelial dedifferentiation. In vivo, genetic ablation of Id1 in mice reduced peritubular inflammation and decreased tubular expression of RANTES following ureteral obstruction. Mice lacking Id1 were also protected against myofibroblast activation and matrix expression, leading to a reduced total collagen deposition in obstructive nephropathy. Thus, these results indicate that Id1 shuttles between nucleus and cytoplasm, and promotes peritubular inflammation and tubular epithelial dedifferentiation, suggesting that these two events are intrinsically coupled during renal fibrogenesis. PMID:22278018

Li, Yingjian; Wen, Xiaoyan; Liu, Youhua

2012-05-01

498

Development and Psychometric Properties of an Assessment for Persons with Intellectual Disability--The InterRAI ID  

ERIC Educational Resources Information Center

This paper describes the development of the interRAI-Intellectual Disability (interRAI ID), a comprehensive instrument that assesses all key domains of interest to service providers relative to a person with an intellectual disability (ID). The authors report on the reliability and validity of embedded scales for cognition, self-care, aggression,…

Martin, Lynn; Hirdes, John P.; Fries, Brant E.; Smith, Trevor F.

2007-01-01

499

Id1 expression promotes peripheral CD4{sup +} T cell proliferation and survival upon TCR activation without co-stimulation  

SciTech Connect

Highlights: •Id1 expression enables naïve T cell proliferation without anti-CD28 co-stimulation. •Id1 expression facilitates T cells survival when stimulated with anti-CD3. •Elevation of IL-2 production by Id1 contributes increased proliferation and survival. •Id1 potentiates NF-?B activation by anti-CD3 stimulation. -- Abstract: Although the role of E proteins in the thymocyte development is well documented, much less is known about their function in peripheral T cells. Here we demonstrated that CD4 promoter-driven transgenic expression of Id1, a naturally occurring dominant-negative inhibitor of E proteins, can substitute for the co-stimulatory signal delivered by CD28 to facilitate the proliferation and survival of naïve CD4{sup +} cells upon anti-CD3 stimulation. We next discovered that IL-2 production and NF-?B activity after anti-CD3 stimulation were significantly elevated in Id1-expressing cells, which may be, at least in part, responsible for the augmentation of their proliferation and survival. Taken together, results from this study suggest an important role of E and Id proteins in peripheral T cell activation. The ability of Id proteins to by-pass co-stimulatory signals to enable T cell activation has significant implications in regulating T cell immunity.

Liu, Chen; Jin, Rong [Department of Immunology, Peking University Health Science Center, Beijing (China)] [Department of Immunology, Peking University Health Science Center, Beijing (China); Wang, Hong-Cheng [Oklahoma Medical Research Foundation, Oklahoma City, OK (United States)] [Oklahoma Medical Research Foundation, Oklahoma City, OK (United States); Tang, Hui; Liu, Yuan-Feng; Qian, Xiao-Ping; Sun, Xiu-Yuan; Ge, Qing [Department of Immunology, Peking University Health Science Center, Beijing (China)] [Department of Immunology, Peking University Health Science Center, Beijing (China); Sun, Xiao-Hong, E-mail: sunx@omrf.org [Oklahoma Medical Research Foundation, Oklahoma City, OK (United States)] [Oklahoma Medical Research Foundation, Oklahoma City, OK (United States); Zhang, Yu, E-mail: zhangyu007@bjmu.edu.cn [Department of Immunology, Peking University Health Science Center, Beijing (China)] [Department of Immunology, Peking University Health Science Center, Beijing (China)

2013-06-21

500

Health Professionals' Attitudes and Emotions towards Working with Adults with Intellectual Disability (ID) and Mental Ill Health  

ERIC Educational Resources Information Center

Objectives: Mainstream mental health services are providing more care for individuals with an intellectual disability (ID); this has implications for staff and service users. Attitudes of staff towards people with ID in mental health services may be negative and negative staff attitudes may have a detrimental impact on service provision. Design: A…

Rose, N.; Kent, S.; Rose, J.

2012-01-01