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Sample records for sir james crichton-browne

  1. Sir James Lighthill

    NASA Astrophysics Data System (ADS)

    Crighton, D. G.

    1999-05-01

    James Lighthill died on 17 July 1998, at the end of a ten-hour swim round the Channel Island of Sark. He had earlier, at age 49, been the first person ever to do this, and he was carrying out the swim for the seventh time when the exertion revealed a mitral valve weakness which had never been diagnosed, and which led to his sudden death in the water. The swim was one of many long ‘adventure swims’ which Lighthill liked to take, all characterized by strong tidal currents and often heavy seas. And Lighthill took much pleasure through exercising his comprehensive understanding of fluid mechanics first in preparing for them through study of local conditions and then in adapting his performance when, as often, he found that in practice the currents were not as charted and, in fact, often more treacherous.

  2. Sir James Paget and his contributions to pathology.

    PubMed Central

    Turk, J. L.

    1995-01-01

    Sir James Paget's Lectures on Surgical Pathology, published in 1853, was based on Lectures given at the Royal College of Surgeons of England in the previous six years. It makes use of the pathological material collected by John Hunter in the late eighteenth century which was housed in the College. It expands the principles of pathophysiology enunciated by Hunter using microscopic observations. The first half of the book covers mainly inflammation and repair; the second is involved in a description of tumours with particular emphasis on the difference between benign and malignant growths. This book indicates a concept of pathology before the realization of the role of infectious organisms. However, there is some inkling of the contagious nature of syphilis and variola following on Hunter's work. The concept, current at that time, that tuberculosis was related to cancer is expressed. This work acts as a bridge between the pathology of John Hunter and that of the present time. Images Figure 1 PMID:8652365

  3. Experimental tectonics: from Sir James Hall to the present

    NASA Astrophysics Data System (ADS)

    Ranalli, Giorgio

    2001-09-01

    The subject of experimental tectonics is the study of geodynamic processes by means of laboratory scale models. The first roughly scaled experiments were performed by Sir James Hall about two centuries ago, in the intellectual atmosphere generated by the appearance of Hutton's Theory of the Earth (Hutton, J., 1795. Theory of the Earth, with Proofs and Illustrations, Vols. I & II. Cadell & Davies, Edinburgh). Their aim was to test the hypothesis that the folding of originally horizontal strata is the result of lateral compression. The idea to test hypotheses by laboratory experiments had already been applied by Hall to petrological problems (crystallization and melting) not involving scaling. Interestingly, however, he constructed a scale model of a Gothic cathedral, using a line of reasoning parallel to that used in his tectonic experiments. From these beginnings, the theory and practice of scale models have grown to become an important part of an integrated approach to the study of geodynamics. One topic which is at present the focus of much attention is the choice of model materials correctly scaling the temperature dependence of lithospheric materials. As an example, a brief discussion is offered of two geodynamic problems where the application of scale models is proving very fruitful: the initiation and time-history of subduction of oceanic and continental lithosphere, and the tectonic evolution of orogenic wedges.

  4. Sir James Mackenzie: from auricular paralysis and nodal rhythm to auricular fibrillation.

    PubMed

    Lippi, Donatella; Mascia, Giuseppe; Padeletti, Luigi

    2011-09-01

    The aim of this paper is to underline the role of Sir James Mackenzie in stating that atrial fibrillation is a distinct and clinically important arrhythmia and that it is a common condition in patients with cardiac disease. Around 1900, a few clinical researchers were dealing with cardiac arrhythmias with the use of arterial and venous pulse tracings. Sir James Mackenzie, who has been one of the fathers of modern cardiology, introduced registration of the venous pulse at the bedside using the clinical polygraph he had invented. He applied the results of his experimental and clinical discoveries to the explanation of many kinds of arrhythmias before ECG introduction. In our paper, we have especially considered the three steps of his approach to atrial fibrillation, the first two developed in the pre-ECG era. The invention of an instrument of precision, the electrocardiograph, revolutionized the diagnosis of heart disease and catalyzed the formation of cardiology as a specialty. PMID:21476085

  5. Sir James Mouat, VC KCB FRCS (1815-1899): winner of the first medical Victoria Cross.

    PubMed

    Lawrenson, Ross

    2004-11-01

    Sir James Mouat was the first of 36 doctors to win the Victoria Cross. Born in Kent in 1815, he was educated at University College London before joining the army. After service in India and Ireland he joined the 6th Dragoon Guards as regimental surgeon and served with them throughout the Crimean War. He won his VC at the Battle of Balaclava. After the Crimean War he was appointed principal medical officer to the British troops in the New Zealand Wars. After serving in New Zealand he returned to England and became Inspector General of Hospitals. Surgeon General Mouat retired on 28 April 1876. He was appointed an honorary surgeon to the Queen in 1888, and a Knight Commander of the Order of the Bath in 1894. He died of a stroke on 4 January 1899 at the age of 83. PMID:15486614

  6. Sir James Edward Smith (1759-1828) MD FRS, botanist, co-founder of the Linnean Society of London.

    PubMed

    Hawgood, Barbara J

    2009-05-01

    James Edward Smith's interest in botany led him to enter medicine at Edinburgh in 1781. Smith was continuing his medical studies in London when Sir Joseph Banks (1743-1820) suggested to him that he should purchase the collection of the famous Swedish naturalist Carl Linnaeus that had just been offered to Banks. Smith bought the Linnean Collection and Library in 1784. In 1786 he was awarded the degree of Doctor of Medicine from Leiden. In 1788 Smith, with two associates, founded the Linnean Society of London and became President for life. Smith turned from medicine to natural history as a lecturer and writer. During his lifetime he produced numerous botanical works of high value, including The English Flora (1824-28), and he did much to popularize botany. PMID:19401517

  7. Sir James Jeans

    NASA Astrophysics Data System (ADS)

    Milne, E. A.

    2013-09-01

    Memoir by S. C. Roberts; 1. Merchant Taylor's and Cambridge; 2. Princeton, 1905-9; 3. Return to England. The Adams Prize essay, 1909-19; 4. Secretary of the Royal Society, 1919-29; 5. Popular exposition, 1929-30; 6. Later years, 1931-46; 7. Science in Jeans's boyhood; 8. The partition of energy; 9. Rotating fluid masses; 10. Star clusters; 11. The equilibrium of the stars; 12. Jeans and philosophy; Bibliography; Index.

  8. James Bay

    Atmospheric Science Data Center

    2013-04-17

    article title:  First Views of James Bay, Canada     ... show the winter landscape of James Bay, Ontario, Canada from three of the instrument's nine cameras. The image at left captures the opening ... down. The image on the right was taken seven minutes after the first image from the most oblique, aftward-viewing camera. "These ...

  9. James Bay

    Atmospheric Science Data Center

    2013-04-17

    article title:  First Light over James Bay     View Larger Image MISR "First light", 16:40 UTC, 24 February 2000 . This is the first image of Earth's ... the line of flight. At the top of the image, the dark-to-light transition captures the opening of the MISR cover. Progressing southward, ...

  10. Sir Alec Clegg

    ERIC Educational Resources Information Center

    Brighouse, Tim

    2008-01-01

    This article is a personal view of the career of Sir Alec Clegg. It outlines some of Clegg's achievements in the West Riding, and why he was so influential on those that he worked with. Finally, it retells one of Alec Clegg's favourite stories "The fable of Fred".

  11. Influenza SIRS with Minimal Pneumonitis

    PubMed Central

    Erramilli, Shruti; Mannam, Praveen; Manthous, Constantine A.

    2016-01-01

    Although systemic inflammatory response syndrome (SIRS) is a known complication of severe influenza pneumonia, it has been reported very rarely in patients with minimal parenchymal lung disease. We here report a case of severe SIRS, anasarca, and marked vascular phenomena with minimal or no pneumonitis. This case highlights that viruses, including influenza, may cause vascular dysregulation causing SIRS, even without substantial visceral organ involvement.

  12. William James's Moral Theory

    ERIC Educational Resources Information Center

    Cooper, Wesley

    2003-01-01

    James's moral theory, primarily as set out in "The Moral Philosopher and the Moral Life" (in his "The Will To Believe" (1897)), is presented here as having a two-level structure, an empirical or historical level where progress toward greater moral inclusiveness is central, and a metaphysical or end-of-history level--James's "kingdom of…

  13. The demographic work of Sir William Wilde.

    PubMed

    Froggatt, P

    2016-05-01

    This paper argues that Sir William Wilde was indeed a pioneering demographer. It also describes the unveiling of the plaque commemorating Sir William Wilde at his home, 1, Merrion Square, Dublin on the 28 October 1971. PMID:27083459

  14. New Zealand SIR-B science investigations

    NASA Technical Reports Server (NTRS)

    Collins, M. A.; Oliver, P. J.; Cochrane, G. R.; Cole, J.; Coombs, D. S.; Barnes, E. J.; Ching, N. P.; Bennets, R. L.; Stephens, P. H.; Laing, A. K.

    1984-01-01

    It is proposed that shuttle imaging radar (SIR) data be used to study unusual geological features of New Zealand. Particular attention is planned for geological faults. SIR-B imagery is to be compared with LANDSAT multispectral imagery. Three other investigations which are to use SIR data are discussed. An ocean eddy is to be studied from a correlation of SIR-B and advanced very high resolution radiometer imagery. Timber volume is to be assessed by determining the age and size of pine forests from SIR-B data. Soil moisture is to be investigated by comparing SIR-B data with simultaneous gravimetric data. Land cover in a region already subjected to intensive investigation using LANDSAT and aircraft scanner data is to be discriminated by SIR-B data.

  15. A nonlinear SIR with stability

    NASA Astrophysics Data System (ADS)

    Trisilowati, Darti, I.; Fitri, S.

    2014-02-01

    The aim of this work is to develop a mathematical model of a nonlinear susceptible-infectious-removed (SIR) epidemic model with vaccination. We analyze the stability of the model by linearizing the model around the equilibrium point. Then, diphtheria data from East Java province is fitted to the model. From these estimated parameters, we investigate which parameters that play important role in the epidemic model. Some numerical simulations are given to illustrate the analytical results and the behavior of the model.

  16. SIR-B iceberg observation

    NASA Astrophysics Data System (ADS)

    Carsey, Frank

    The Shuttle Imaging Radar (SIR) made its second flight (called SIR-B) in October 1984. Among the 44 science projects that it was due to support were two ice-related studies, one concerning the behavior of the sea ice of the southern ocean pack and marginal ice zones and another concerning the detectability of icebergs and other navigational hazards off the east coast of Canada. The southern ocean sea ice team was led by F. Carsey of the Jet Propulsion Laboratory (JPL), Pasadena, Calif., and consisted of B. Holt (JPL), S. Martin (University of Washington, Seattle), L. Mc-Nutt (Radarsat, Ottawa), D.A. Rothrock (Polar Science Center, Seattle), W.F. Weeks (U.S. Army Cold Regions Research and Engineering Laboratory, Hanover, N.H.), and V. Squire (Canada Centre for Remote Sensing (CCRS), Ottawa); the iceberg team was led by A.L. Gray (CCRS) and consisted of J.Princz, C.E. Livingstone, R.K. Hawkins, M. Wong (all of CCRS), D. Pearson (Petro-Canada Exploration, Calgary, Canada), J. Gower (Institute of Ocean Sciences, Sydney, Canada), T.F. Mullane, and R.O. Ramseier (both of the Atmospheric Environment Service, Ottawa). As it happened, the SIR-B mission experienced difficulty with its data link to a geostationary relay satellite and with the SIR-B radar transmitter, with the consequences that the total amount of data taken was only about one fifth of what was planned and that the data quality was impaired in comparison to what had been anticipated. The result was that no iceberg synthetic aperture radar (SAR) images off the Canadian coast and very limited sea ice SAR images in the southern ocean were acquired; however, a few interesting SAR images of the southern ocean icebergs were acquired, and a few of these are shown in Figure 1.

  17. James Joule and meteors

    NASA Astrophysics Data System (ADS)

    Hughes, David W.

    1989 was the hundredth anniversary of the death of James Prescott Joule, the Prescott being his mother's family name and the Joule, rhyming with cool, originating from the Derbyshire village of Youlgreave. Joule is rightly famous for his experimental efforts to establish the law of conservation of energy, and for the fact that J, the symbol known as the mechanical equivalent of heat, is named after him. Astronomically his "light has been hidden under a bushel". James Joule had a major influence on the physics of meteors.

  18. How James Wood Works

    ERIC Educational Resources Information Center

    Goldstein, Evan R., Comp.

    2008-01-01

    Reading through news-media clippings about James Wood, one might reasonably conclude that "pre-eminent critic" is his official job title. In fact, Wood is a staff writer for "The New Yorker" and a professor of the practice of literary criticism at Harvard University. But at a time when there is much hand-wringing about the death of the…

  19. James Ferguson remembered

    NASA Astrophysics Data System (ADS)

    Davenhall, Clive

    2012-03-01

    The year 2010 marked the three hundredth anniversary of the birth of the astronomer, author and lecturer James Ferguson (1710-1776). Subsequently I visited the site of the churchyard where Ferguson is buried. He is mentioned in a plaque on the site and I thought that the details might be of interest.

  20. Reply to James Muir

    ERIC Educational Resources Information Center

    White, John

    2004-01-01

    In "EPAT", vol. 36, no. 1, 2004, James Muir takes the author and fellow philosophers of education to task for their ignorance of the history of philosophy of education. "[T]oo many currently influential educationists, Professor White in particular, are literally unaware that educational philosophy has a history more than three hundred years in…

  1. A fractional-order infectivity SIR model

    NASA Astrophysics Data System (ADS)

    Angstmann, C. N.; Henry, B. I.; McGann, A. V.

    2016-06-01

    Fractional-order SIR models have become increasingly popular in the literature in recent years, however unlike the standard SIR model, they often lack a derivation from an underlying stochastic process. Here we derive a fractional-order infectivity SIR model from a stochastic process that incorporates a time-since-infection dependence on the infectivity of individuals. The fractional derivative appears in the generalised master equations of a continuous time random walk through SIR compartments, with a power-law function in the infectivity. We show that this model can also be formulated as an infection-age structured Kermack-McKendrick integro-differential SIR model. Under the appropriate limit the fractional infectivity model reduces to the standard ordinary differential equation SIR model.

  2. The SIR-B science plan

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The Shuttle Imaging Radar-B (SIR-B) will be the third in a series of spaceborne SAR experiments conducted by NASA which began with the 1978 launch of SEASAT and continued with the 1981 launch of SIR-A. Like SEASAT and SIR-A, SIR-B will operate at L-band and will be horizontally polarized. However, SIR-B will allow digitally processed imagery to be acquired at selectable incidence angles between 15 and 60 deg, thereby permitting, for the first time, parametric studies of the effect of illumination geometry on SAR image information extraction. This document presents a science plan for SIR-B and serves as a reference for the types of geoscientific, sensor, and processing experiments which are possible.

  3. William James's Talks about Teaching

    ERIC Educational Resources Information Center

    Brewer, Charles L.

    2003-01-01

    More than 100 years after it was published, William James's (1899/1939) book, "Talks to Teachers on Psychology," is relevant and helpful for teachers and those who aspire to teach. In this article, I highlight certain memorable points in "Talks" and relate them to James's (1890) classic work, "The Principles of Psychology." Many of James's…

  4. William James on Teaching Democracy.

    ERIC Educational Resources Information Center

    Miller, Joshua

    1998-01-01

    Analyzes philosopher William James' writings on political representation and participatory democracy. Although he argued in favor of democratic principles, James also strongly supported the role of a well-educated elite serving as leaders. Attempts to reconcile these contradictory positions and considers James' influence on the development of…

  5. Parallelization of the SIR code

    NASA Astrophysics Data System (ADS)

    Thonhofer, S.; Bellot Rubio, L. R.; Utz, D.; Jurčak, J.; Hanslmeier, A.; Piantschitsch, I.; Pauritsch, J.; Lemmerer, B.; Guttenbrunner, S.

    A high-resolution 3-dimensional model of the photospheric magnetic field is essential for the investigation of small-scale solar magnetic phenomena. The SIR code is an advanced Stokes-inversion code that deduces physical quantities, e.g. magnetic field vector, temperature, and LOS velocity, from spectropolarimetric data. We extended this code by the capability of directly using large data sets and inverting the pixels in parallel. Due to this parallelization it is now feasible to apply the code directly on extensive data sets. Besides, we included the possibility to use different initial model atmospheres for the inversion, which enhances the quality of the results.

  6. James R. Thompson

    NASA Technical Reports Server (NTRS)

    1986-01-01

    James R. Thompon served as director of the Marshall Space Flight Center from September 29, 1986 until July 6, 1989, when he was appointed as NASA Deputy Administrator. Prior to his tenure as Marshall's Director, Thompson served from March to June 1986 as the vice-chairman of the NASA task force investigating the cause of the Space Shuttle Challenger accident. He was credited with playing a significant role in returning the Space Shuttle to flight following the Challenger disaster.

  7. Stability of stochastic switched SIRS models

    NASA Astrophysics Data System (ADS)

    Meng, Xiaoying; Liu, Xinzhi; Deng, Feiqi

    2011-11-01

    Stochastic stability problems of a stochastic switched SIRS model with or without distributed time delay are considered. By utilizing the Lyapunov methods, sufficient stability conditions of the disease-free equilibrium are established. Stability conditions about the subsystem of the stochastic switched SIRS systems are also obtained.

  8. The SIR-2 Experiment on Chandrayaan-1

    NASA Astrophysics Data System (ADS)

    Mall, U.; Nathues, A.; SIR-2 Collaboration

    2009-04-01

    The SIR-2 experiment, flying on the Indian Chandrayaan-1 mission to the Moon, is a near-infrared point spectrometer of the second-generation built by a European collaboration around the Max-Planck Institute for Solar System Research. SIR-2 has been designed based on the heritage of the SIR Technology experiment on ESA's SMART-1 mission, in order to investigate the mineralogical composition of the Moon for a period of two years. The SIR-2 instrument, which will operate in conjunction with the Indian Hyper-Spectral Imaging spectrometer (HySI) on board Chandrayaan-1, will cover, together with HySi, a combined spectral range of 0.4 to 2.4 m. We will explain the SIR-2 experiment and report on the performance of the instrument during its commissioning phase to deliver high spatial and spectral near-infrared data from its first 100 km polar orbits around the Moon.

  9. Joint Scientific Papers of James Prescott Joule

    NASA Astrophysics Data System (ADS)

    Prescott Joule, James

    2011-06-01

    Experiments and observations on the mechanical powers of electro-magnetism, steam, and horses with Dr. Scoresby; On atomic volume and specific gravity with Sir Lyon Playfair; On the thermal effects experienced by air in rushing through small apertures with Sir Wm. Thomson; On the thermal effects of fluids in motion with Sir Wm. Thomson; On the thermal effects of elastic fluids with Sir Wm. Thomson; On the thermal effects of fluids in motion with Sir Wm. Thomson.

  10. Sir William Wilde: an enlightened editor.

    PubMed

    O'Doherty, M

    2016-05-01

    This paper examines Sir William Wilde's peculiar genius as editor, his contribution to the Irish Journal of Medical Science in ensuring its endurance and making it a treasure-house of the history of medicine in Ireland. PMID:26969455

  11. Stability of SIRS system with random perturbations

    NASA Astrophysics Data System (ADS)

    Lu, Qiuying

    2009-09-01

    Epidemiological models with bilinear incidence rate λSI usually have an asymptotically stable trivial equilibrium corresponding to the disease-free state, or an asymptotically stable non-trivial equilibrium (i.e. interior equilibrium) corresponding to the endemic state. In this paper, we consider an epidemiological model, which is an SIRS model with or without distributed time delay influenced by random perturbations. We present the stability conditions of the disease-free equilibrium of the associated stochastic SIRS system.

  12. The SIR-B science investigations plan

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Shuttle Imaging Radar-B (SIR-B) is the second synthetic aperture radar (SAR) to be flown on the National Aeronautics and Space Administration's Space Transportation System (Shuttle). It is the first spaceborne SAR to feature an antenna that allows acquisition of multiincidence angle imagery. An international team of scientists will use SIR-B to conduct investigations in a wide range of disciplines. The radar, the mission, and the investigations are described.

  13. Sir Hans Sloane (1660–1735): his life and legacy

    PubMed Central

    Hawkins, Stanley A

    2010-01-01

    Sir Hans Sloane was born in Killyleagh, Co Down, the seventh and last son of Alexander Sloane. His father, who was of Scottish ancestry, had a long association with James Hamilton, Earl of Clanbrassil who had acquired the castle in Killyleagh and extensive estates in east Down. The Hamilton family took an interest in the education of the Sloane children, and much of the early tuition of Hans was conducted within the library of Killyleagh Castle. In 1679 he moved to London to study medicine and botany. In 1683, he continued his studies in Paris and Montpellier, and graduated from the University of Orange. On his return to London, he became a protégé of Thomas Sydenham. In 1687 he was appointed physician to the Duke of Albemarle and surgeon to the West Indies fleet. While in Jamaica he added countless specimens to his collections, continuing a lifetime passion. He also invented milk chocolate there. Following the untimely death of the duke, he returned to London and built up a fashionable medical practice. He married Elizabeth Langley, heiress of a wealthy city alderman, and widow of a sugar planter in Jamaica. They set up house in Great Russell Street. The family home accommodated his burgeoning collections of books, specimens and curiosities. In 1685 he was elected a Fellow of the Royal Society, later becoming the honorary secretary and president. Following his death, his collections were bought for the nation and formed the foundation of the British Museum. PMID:20844729

  14. James E. Keeler Pioneer Astrophysicist.

    ERIC Educational Resources Information Center

    Osterbrock, Donald E.

    1979-01-01

    Gives a short biography of James E. Keeler, and describes some of his outstanding discoveries, and his pioneering work in observational research where he applied physical methods to the analysis of planets, stars and nebulae. (GA)

  15. Sir Charles James Martin MB FRS: Australian serpents and Indian plague, one-hundred years ago.

    PubMed

    Hawgood, B J

    1997-07-01

    In 1891 as Demonstrator in Physiology at the University of Sydney, Charles Martin began the first systematic study of the chemical and physiological properties of the venoms of the Australian elapid species, Pseudechis porphyriacus and Notechis scutatus. Two major constituents were detected: a large coagulable protein which was associated with intravascular clotting, and a small proteinaceous molecule, an albumose, associated with neurotoxicity. Martin designed and constructed a high-pressure gelatin membrane ultrafilter for fractionation of venom. His studies indicated that certain physiological actions and clinical symptoms were related to the faster rate of diffusion within the tissue space of a neurotoxic constituent relative to a clotting constituent. Extending this work to toxin-antitoxin relationships, Martin provided evidence that antitoxin was a large molecule with slow diffusibility in tissue and advised the administration of curative serum (including diphtheria antitoxin) by intravenous injection. In 1903, Martin returned to London as Director of the Lister Institute of Preventive Medicine. He was soon involved in the planning of scientific work to be undertaken by the Commission for Investigation of Plague in India as the disease continued to ravage the subcontinent. Detailed epidemiological studies of possible factors involved in the spread of Pasteurella pestis showed, unequivocally, that infected rat fleas were the vector of transmission from rats to humans. PMID:9247999

  16. Tectonic geomorphology of the Andes with SIR-A and SIR-B

    NASA Technical Reports Server (NTRS)

    Bloom, Arthur L.; Fielding, Eric J.

    1986-01-01

    Data takes from SIR-A and SIR-B (Shuttle Imaging Radar) crossed all of the principal geomorphic provinces of the central Andes between 17 and 34 S latitude. In conjunction with Thematic Mapping images and photographs from hand-held cameras as well as from the Large Format Camera that was flown with SIR-B, the radar images give an excellent sampling of Andean geomorphology. In particular, the radar images show new details of volcanic rocks and landforms of late Cenozoic age in the Puna, and the exhumed surfaces of tilted blocks of Precambrian crystalline basement in the Sierras Pampeanas.

  17. Shuttle Imaging Radar-C (SIR-C): Executive summary

    NASA Technical Reports Server (NTRS)

    1983-01-01

    The scientific and technological objectives of the Shuttle Imaging Radar-C (SIR-C) Project are reviewed. Information regarding the implementation philosophy and approach, and the relationship of the project to the overall SIR program is also provided.

  18. SIR technology helps ensure safe landings for NASA

    NASA Astrophysics Data System (ADS)

    Kratochvil, Gary; Fenner, Thomas; Benson, Richard

    1992-12-01

    The use of a subsurface interface radar (SIR) system to ensure that lake-bed runways are free of unseen fissures and voids is described. SIR systems nonintrusively detect anomalies underground or embedded in concrete and other man-made materials. The effectiveness of an SIR system is influenced by the type of soil, with best results obtained for dry, sandy soil. Results of the application of SIR technology to Edwards AFB runways are summarized.

  19. Sir Sandford Fleming College Repositioning Strategies Report.

    ERIC Educational Resources Information Center

    Sir Sandford Fleming Coll., Peterborough (Ontario).

    This report describes repositioning strategies undertaken by Sir Sandford Fleming College, in Ontario, to respond to changing student demographics, educational demands, and reduced funding. Following opening remarks by the college president providing an overview of the strategies and the use of all-staff meetings to generate responses from the…

  20. Cooperative stabilization of the SIR complex provides robust epigenetic memory in a model of SIR silencing in Saccharomyces cerevisiae

    PubMed Central

    Sneppen, Kim; Dodd, Ian B

    2015-01-01

    How alternative chromatin-based regulatory states can be made stable and heritable in order to provide robust epigenetic memory is poorly understood. Here, we develop a stochastic model of the silencing system in Saccharomyces cerevisiae that incorporates cooperative binding of the repressive SIR complex and antisilencing histone modifications, in addition to positive feedback in Sir2 recruitment. The model was able to reproduce key features of SIR regulation of an HM locus, including heritable bistability, dependence on the silencer elements, and sensitivity to SIR dosage. We found that antisilencing methylation of H3K79 by Dot1 was not needed to generate these features, but acted to reduce spreading of SIR binding, consistent with its proposed role in containment of silencing. In contrast, cooperative inter-nucleosome interactions mediated by the SIR complex were critical for concentrating SIR binding around the silencers in the absence of barriers, and for providing bistability in SIR binding. SIR-SIR interactions magnify the cooperativity in the Sir2-histone deacetylation positive feedback reaction and complete a double-negative feedback circuit involving antisilencing modifications. Thus, our modeling underscores the potential importance of cooperative interactions between nucleosome-bound complexes both in the SIR system and in other chromatin-based complexes in epigenetic regulation. PMID:25830651

  1. Cooperative stabilization of the SIR complex provides robust epigenetic memory in a model of SIR silencing in Saccharomyces cerevisiae.

    PubMed

    Sneppen, Kim; Dodd, Ian B

    2015-01-01

    How alternative chromatin-based regulatory states can be made stable and heritable in order to provide robust epigenetic memory is poorly understood. Here, we develop a stochastic model of the silencing system in Saccharomyces cerevisiae that incorporates cooperative binding of the repressive SIR complex and antisilencing histone modifications, in addition to positive feedback in Sir2 recruitment. The model was able to reproduce key features of SIR regulation of an HM locus, including heritable bistability, dependence on the silencer elements, and sensitivity to SIR dosage. We found that antisilencing methylation of H3K79 by Dot1 was not needed to generate these features, but acted to reduce spreading of SIR binding, consistent with its proposed role in containment of silencing. In contrast, cooperative inter-nucleosome interactions mediated by the SIR complex were critical for concentrating SIR binding around the silencers in the absence of barriers, and for providing bistability in SIR binding. SIR-SIR interactions magnify the cooperativity in the Sir2-histone deacetylation positive feedback reaction and complete a double-negative feedback circuit involving antisilencing modifications. Thus, our modeling underscores the potential importance of cooperative interactions between nucleosome-bound complexes both in the SIR system and in other chromatin-based complexes in epigenetic regulation. PMID:25830651

  2. Dr James Currie (1756-1805): Liverpool physician, campaigner, hydrotherapist and man of letters.

    PubMed

    Halliday, Stephen

    2006-02-01

    James Currie was born and educated in Scotland but spent most of his professional life in Liverpool, where, as physician to the Liverpool Infirmary, he campaigned against the unsanitary living conditions in the rapidly growing port. He was an early advocate of water cures for fever and other maladies, on which subject he carried out experiments and published a seminal work. He was a pioneer in the use of the clinical thermometer. He was also an early advocate of the abolition of slavery and a man with literary and scientific interests, which brought him into contact with many of his most distinguished contemporaries. These included Erasmus Darwin (1731-1802), William Wilberforce (1759-1833), Sir Walter Scott (1771-1832), Sir Joseph Banks (1743-1820) and Robert Burns (1759-96), of whose poetry Currie was the first editor. He died in August 1805 at Sidmouth in Devon, whose parish church carries his memorial. PMID:16435032

  3. Foreword: Sir John Pendry FRS Sir John Pendry FRS

    NASA Astrophysics Data System (ADS)

    Inglesfield, John; Echenique, Pedro

    2008-07-01

    scattering is much weaker, and this allowed him to develop a method of successive approximation. The material and the calculation are cut up into a series of atomic slices, and the electronic structure solved without approximation in each slice. Being two-dimensional, this was much more manageable than a full three-dimensional calculation. Then the slices could be put together by a sort of perturbation theory to calculate the scattering current as a function of energy along each of the reciprocal lattice 'rods' allowed by the surface periodicity. John didn't just stop at having solved the problem in principle, he also developed a suite of computer codes to do the job in a routine way. He even published the code for all to use, and I believe that to the present day the calculations are still done effectively in the same way. Without the calculations, one cannot interpret the data in terms of a surface atomic structure. Effectively one is doing a computer experiment in parallel to the laboratory experiment, and one fiddles more or less systematically with the surface structure until one gets agreement between the simulations and the laboratory data. One of the things that John noticed was that the process of photoemission (UPS) from a surface is rather similar, and can be calculated in an analogous way. This suddenly became very important because the new synchrotron at Daresbury was about to become operational, pumping out billions of photons for solid state research. Sam Edwards (now Sir Sam) was head of SRC (forerunner of EPSRC) at the time and recognised the problem of interpreting all the data that the machine would provide. And after UPS would come EXAFS, and after that XANES and all the rest of the alphabet soup. With that foresight, unusual at the time, John Pendry was appointed to head the theory group at Daresbury. Previously the theoreticians had revolved around the nuclear physics accelerator, and John had to turn it completely around and refocus it, which he did

  4. Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast

    PubMed Central

    Hannan, Abdul; Abraham, Neethu Maria; Goyal, Siddharth; Jamir, Imlitoshi; Priyakumar, U. Deva; Mishra, Krishnaveni

    2015-01-01

    Silent information regulator 2 (Sir2), the founding member of the conserved sirtuin family of NAD+-dependent histone deacetylase, regulates several physiological processes including genome stability, gene silencing, metabolism and life span in yeast. Within the nucleus, Sir2 is associated with telomere clusters in the nuclear periphery and rDNA in the nucleolus and regulates gene silencing at these genomic sites. How distribution of Sir2 between telomere and rDNA is regulated is not known. Here we show that Sir2 is sumoylated and this modification modulates the intra-nuclear distribution of Sir2. We identify Siz2 as the key SUMO ligase and show that multiple lysines in Sir2 are subject to this sumoylation activity. Mutating K215 alone counteracts the inhibitory effect of Siz2 on telomeric silencing. SUMO modification of Sir2 impairs interaction with Sir4 but not Net1 and, furthermore, SUMO modified Sir2 shows predominant nucleolar localization. Our findings demonstrate that sumoylation of Sir2 modulates distribution between telomeres and rDNA and this is likely to have implications for Sir2 function in other loci as well. PMID:26319015

  5. James Frey: Feelings as Facts

    ERIC Educational Resources Information Center

    Travis, Trysh

    2006-01-01

    James Frey, author of the book "A Million Little Pieces" is accused of embellishing and/or fabricating elements of his story, a graphic but supposedly honest, depiction of his struggle with drugs and alcohol. More and more college students who are caught plagiarizing believe, as Frey seems to, that as long as one agrees with the authors one…

  6. John James Audubon & the Turkey

    ERIC Educational Resources Information Center

    Hinshaw, Craig

    2012-01-01

    In the first half of the 1800s, John James Audubon roamed the wilds of America attempting to draw all the birds in their natural habitat. He published his life-sized paintings in a huge book entitled "Birds of America." Audubon developed a unique system of depicting the birds in natural poses, such as flying. After shooting the bird, he would wire…

  7. Oscillations in SIRS model with distributed delays

    NASA Astrophysics Data System (ADS)

    Gonçalves, S.; Abramson, G.; Gomes, M. F. C.

    2011-06-01

    The ubiquity of oscillations in epidemics presents a long standing challenge for the formulation of epidemic models. Whether they are external and seasonally driven, or arise from the intrinsic dynamics is an open problem. It is known that fixed time delays destabilize the steady state solution of the standard SIRS model, giving rise to stable oscillations for certain parameters values. In this contribution, starting from the classical SIRS model, we make a general treatment of the recovery and loss of immunity terms. We present oscillation diagrams (amplitude and period) in terms of the parameters of the model, showing how oscillations can be destabilized by the shape of the distributions of the two characteristic (infectious and immune) times. The formulation is made in terms of delay equations which are both numerically integrated and linearized. Results from simulations are included showing where they support the linear analysis and explaining why not where they do not. Considerations and comparison with real diseases are presented along.

  8. Sir Bernard Lovell (1913-2012)

    NASA Astrophysics Data System (ADS)

    Argo, Megan

    2013-01-01

    Sir Bernard Lovell, founder and first Director of Jodrell Bank Observatory (UK), died on August 6th, 2012, at the age of 98. Lovell was one of the pioneers of radio astronomy. Much of his observational work in the early days of the Observatory focused on radio meteors. Using ex-army radar equipment, Lovell and his colleagues recorded the spectacular Draconid storm of October 1946 and went on to publish many papers in the field, settling some of the big arguments of the time. Sir Bernard's legacy is immense, extending from his wartime work on military radar systems to his pioneering contributions to radio astronomy, and including his dedication to education and public engagement with scientific research.

  9. SIR: Stokes Inversion based on Response functions

    NASA Astrophysics Data System (ADS)

    Ruiz Cobo, B.; del Toro Iniesta, J. C.

    2012-12-01

    SIR is a general-purpose code capable of dealing with gradients of the physical quantities with height. It admits one and two-component model atmospheres. It allows the recovery of the stratification of the temperature, the magnetic field vector, and the line of sight velocity through the atmosphere, and the micro- and macroturbulence velocities - which are assumed to be constant with depth. It is based on the response functions, which enter a Marquardt nonlinear least-squares algorithm in a natural way. Response functions are calculated at the same time as the full radiative transfer equation for polarized light is integrated, which determines values of many free parameters in a reasonable computation time. SIR demonstrates high stability, accuracy, and uniqueness of results, even when simulated observations present signal-to-noise ratios of the order of the lowest acceptable values in real observations.

  10. Magic, Mind Control, and the Body Electric: "Materia Medica" in Sir Walter Scott's Library at Abbotsford.

    PubMed

    Levy, Lindsay

    2014-01-01

    This chapter examines the medical texts, or "Materia Medica", held by Sir Walter Scott in his library at Abbotsford. While the vast majority of Scott's medical texts are antiquarian, his library also contains rare tracts and ephemera relating to the medical practice of the infamous quack, Dr James Graham (1745-94), and the Burke and Hare controversy of 1828 and its aftermath. Examining Scott's holdings of medical texts in relation to his own health and that of his family and friends, it is argued that the lack of contemporary medical self-help texts in his library is striking and indicative of his stoical attitude towards health, despite his clear interest in medical culture. PMID:27132356

  11. The Scientific Papers of James Clerk Maxwell

    NASA Astrophysics Data System (ADS)

    Clerk Maxwell, James; Niven, W. D.

    2011-01-01

    27. On the viscosity or internal friction of air and other gases; 28. On the dynamical theory of gases; 29. On the theory of the maintenance of electric currents by mechanical work without the use of permanent magnets; 30. On the equilibrium of a spherical envelope; 31. On the best arrangement for producing a pure spectrum on a screen; 32. The construction of stereograms of surfaces; 33. On reciprocal diagrams in space and their relation to Airy's function of stress; 34. On governors; 35. Experiment in magneto-electric induction; 36. On a method of making a direct comparison of electrostatic with electromagnetic force; 37. On the cyclide; 38. On a bow seen on the surface of ice; 39. On reciprocal figures, frames, and diagrams of forces; 40. On the displacement in a case of fluid motion; 41. Address to the mathematical and physical sections of the British Association, 1870; 42. On colour-vision at different points of the retina; 43. On hills and dales; 44. Introductory lecture on experimental physics; 45. On the solution of electrical problems by the transformation of conjugate functions; 46. On the mathematical classification of physical quantities; 47. On colour vision; 48. On the geometrical mean distance of two figures on a plane; 49. On the induction of electric currents in an infinite plane sheet of uniform conductivity; 50. On the condition that, in the transformation of any figure by curvilinear co-ordinates in three dimensions, every angle in the new figure shall be equal to the corresponding angle in the original figure; 51. Reprint of Papers on electrostatics and magnetism. By Sir W. Thomson. (Review); 52. On the proof of the equations of motion of a connected system; 53. On a problem in the calculus of variations in which the solution is discontinuous; 54. On action at a distance; 55. Elements of natural philosophy. By Sir W. Thomson and P. G. Tait. (Review); 56. On the theory of a system of electrified conductors, and other physical theories involving

  12. A comparison of the writings of Sir William Osler and his exemplar, Sir Thomas Browne.

    PubMed Central

    Hookman, P.

    1995-01-01

    Sir William Osler was known throughout his life as a great humanitarian. His writings touched all of us, and to persons of every race, creed, and color, he showed universal feelings of justice and mercy. Osler's writing supports great tolerance for all, yet Osler's contemporaries were far less broad-minded and not free of bigotry. Osler's role model, Sir Thomas Browne, wrote openly about his marked prejudices against Catholics, Jews, Moslems, and even women. This paradox between Osler's tolerance and humanitarianism and the prejudice and bigotry of his time, as well as his role model Browne, are explored. PMID:7581308

  13. Conference James F.Buckli

    ScienceCinema

    None

    2011-04-25

    L'association du personnel a le plaisir d'accueillir Mons. James F.Buckli, astronaute, né en 1947. Il a participé à la mission Space Lab D1 qui pour la première fois mettait 8 personnes sur orbite.L'ass.du pers. remercie aussi Gordon White(s) de la mission américaine d'avoir permis d'organiser cette conférence

  14. Global stability for a class of discrete SIR epidemic models.

    PubMed

    Enatsu, Yoichi; Nakata, Yukihiko; Muroya, Yoshiaki

    2010-04-01

    In this paper, we propose a class of discrete SIR epidemic models which are derived from SIR epidemic models with distributed delays by using a variation of the backward Euler method. Applying a Lyapunov functional technique, it is shown that the global dynamics of each discrete SIR epidemic model are fully determined by a single threshold parameter and the effect of discrete time delays are harmless for the global stability of the endemic equilibrium of the model. PMID:20462293

  15. President of Council-Sir Alec

    ScienceCinema

    None

    2011-04-25

    En décembre 1983 le président de l'Association du Personnel du Cern a suggéré d'inviter le président du conseil à une réunion du personnel dans le but d'améliorer la communication entre le conseil et le personnel. Le DG H.schopper remercie le président du conseil, Sir Alec, d'avoir accepté l'invitation malgré ses nombreux occupations.

  16. Solar and Infrared Radiation Station (SIRS) Handbook

    SciTech Connect

    Stoffel, T

    2005-07-01

    The Solar Infrared Radiation Station (SIRS) provides continuous measurements of broadband shortwave (solar) and longwave (atmospheric or infrared) irradiances for downwelling and upwelling components. The following six irradiance measurements are collected from a network of stations to help determine the total radiative flux exchange within the Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) Climate Research Facility: • Direct normal shortwave (solar beam) • Diffuse horizontal shortwave (sky) • Global horizontal shortwave (total hemispheric) • Upwelling shortwave (reflected) • Downwelling longwave (atmospheric infrared) • Upwelling longwave (surface infrared)

  17. Sir John Gurdon: father of nuclear reprogramming.

    PubMed

    Blau, Helen M

    2014-07-01

    Sir John Gurdon founded the field of nuclear reprogramming. His work set the stage for the ever burgeoning area of stem cell biology and regenerative medicine. Here I provide personal reflections on times I shared with John Gurdon and professional reflections of the impact of his ground-breaking research on my own development as a scientist and on the field in general. His paradigm-shifting experiments will continue to provoke scientists to think outside the box for many years to come. PMID:24954777

  18. York, Alcuin, and Sir George Newman

    PubMed Central

    WALKER-SMITH, J

    2001-01-01

    The history of medicine can give insights into past achievements and provide knowledge and even inspiration, a valuable commodity for young students and all doctors. The contribution of Alcuin of York to basic education, and its appreciation by Sir George Newman, medical officer of health and first Chief Medical Officer of the UK in 1919, is recalled. Newman's Quaker education at Bootham School, his views on the main principles of such an education, as well as his influence on its establishment are summarised. A liberal education for doctors is important and knowledge and inspiration from the past may be one factor in enhancing morale.

 PMID:11668116

  19. Sir John Gurdon: Father of nuclear reprogramming

    PubMed Central

    Blau, Helen M.

    2015-01-01

    Sir John Gurdon founded the field of nuclear reprogramming. His work set the stage for the ever burgeoning area of stem cell biology and regenerative medicine. Here I provide personal reflections on times I shared with John Gurdon and professional reflections of the impact of his ground-breaking research on my own development as a scientist and on the field in general. His paradigm-shifting experiments will continue to provoke scientists to think outside the box for many years to come. PMID:24954777

  20. Sir Kenelm Digby (1603-1665): diplomat, entrepreneur, privateer, duellist, scientist and philosopher.

    PubMed

    Mellick, Sam A

    2011-12-01

    Kenelm Digby was a man with widely differing interests. He studied at Oxford but left without a degree. At the age of 20, he was involved in a dramatic street brawl in Madrid; the following year saw him as a successful privateer in the Mediterranean and adjacent Atlantic waters, and he was then appointed a naval administrator with lucrative trade monopolies. He practised medicine without formal qualifications and gained notoriety by promoting the use of 'sympathetic' powder for healing wounds. Befriended by King James I and his son who succeeded him, he became chancellor to Queen Henrietta and was knighted by King James I on 21 October 1623 and appointed to the Privy Council. At one time, he even spent a brief time in prison, but he later became a founding member of the Royal Society and published two major philosophical treatises as well as a popular cookbook. He designed and manufactured wine bottles with tapered necks for simpler pouring and square sides for easy stacking. He dabbled in mathematics and corresponded with Fermat of 'Last Theorem' fame. In 1641, he challenged a French nobleman who publicly cast a slur on the British King to a 'digladiation' (a sword duel) and quickly dispatched him. He was a friend and admirer of Sir Thomas Browne whose 'Religio Medici' he helped to publish. The Cowlishaw Library holds a 1659 5th edition copy of this remarkable book, with Digby's name on the spine. Truly, Digby must qualify as a Renaissance man. PMID:22507419

  1. Seasonal dynamics in an SIR epidemic system.

    PubMed

    Augeraud-Véron, E; Sari, N

    2014-02-01

    We consider a seasonally forced SIR epidemic model where periodicity occurs in the contact rate. This periodical forcing represents successions of school terms and holidays. The epidemic dynamics are described by a switched system. Numerical studies in such a model have shown the existence of periodic solutions. First, we analytically prove the existence of an invariant domain D containing all periodic (harmonic and subharmonic) orbits. Then, using different scales in time and variables, we rewrite the SIR model as a slow-fast dynamical system and we establish the existence of a macroscopic attractor domain K, included in D, for the switched dynamics. The existence of a unique harmonic solution is also proved for any value of the magnitude of the seasonal forcing term which can be interpreted as an annual infection. Subharmonic solutions can be seen as epidemic outbreaks. Our theoretical results allow us to exhibit quantitative characteristics about epidemics, such as the maximal period between major outbreaks and maximal prevalence. PMID:23404038

  2. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Greenhouse, Matthew

    2008-01-01

    The James Webb Space Telescope is being developed by NASA in partnership with the European and Canadian space agencies for launch during 2013. This mission is expected to carry the legacy of discovery of the Hubble Space Telescope through the next decade, and is designed with unique capability to address key questions about formation of the first galaxies after the Big Bang, their subsequelet volution, and the formation of stars and planets within our own galaxy. This talk will present an overview of the mission science objectives and the status of the mission development.

  3. JAMES RIVER FACE WILDERNESS, VIRGINIA.

    USGS Publications Warehouse

    Brown, C. Ervin; Gazdik, Gertrude C.

    1984-01-01

    A mineral survey concluded that the James River Face Wilderness, Virginia, had little promise for the occurrence of metallic mineral resources. Two major rock units in the area do contain large nonmetallic mineral resources of quartzite and shale that have been mined for silica products and for brick and expanded aggregate, respectively. Because large deposits of the same material are more easily available in nearby areas, demand for the deposits within the wilderness is highly unlikely. No energy resources were identified in the course of this study.

  4. The Yellowstone Fires as Observed by SIR-C SAR

    NASA Technical Reports Server (NTRS)

    Rignot, Eric; Despain, Don; Holecz, Francesco

    1996-01-01

    Covers SIR-C (Spaceborne Imaging Radar C) SAR (Synthetic Aperture Radar) imaging of the 1988 Yellowstone National Forest fires. Discusses some of the images and data collected, and some conclusions drawn from them about both the fires, and SIR-C SAR imaging capabilities.

  5. Cloning, expression and characterization of Mycobacterium tuberculosis sirR.

    PubMed

    Namwat, Wises; Somnate, Baramee; Maleehual, Dutsadee; Chareonsudjai, Sorujsiri; Lulitanond, Viraphong; Faksri, Kiatichai

    2014-05-01

    Identification of new drug targets is important for the improvement of chemotherapy for tuberculosis treatment. Metal-associated gene products are candidates for novel drug development. A Mycobacterium tuberculosis (MTB) sirR-encoded protein has been proposed, but the function of MTB SirR has not yet been elucidated. Bioinformatics analysis revealed that MTB SirR contains iron binding domains with 34%-59% similarity to previously described metal-dependent gene regulators and that the gene lies in Rv2787-sirR operon. RT-PCR revealed that the Rv2787-sirR operon is transcribed a single bicistronic mRNA. Heterologous expression, purification and characterization of recombinant MTB His-tagged SirR demonstrated a 25 kDa protein (by SDS-PAGE and immunoblotting) that exists as a dimer (native PAGE). Based on electrophoretic mobility shift assay, MTB SirR bound a cis element located at -85 bp upstream of its operon. As Rv2787-sirR operon is unique only to MTB (and M. bovis), further studies on its regulation and other functions of the encoded proteins should provide leads towards the discovery of novel anti-TB drugs. PMID:24974654

  6. Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.

    PubMed Central

    Smith, J S; Brachmann, C B; Pillus, L; Boeke, J D

    1998-01-01

    Transcriptional silencing in Saccharomyces cerevisiae occurs at the silent mating-type loci HML and HMR, at telomeres, and at the ribosomal DNA (rDNA) locus RDN1. Silencing in the rDNA occurs by a novel mechanism that depends on a single Silent Information Regulator (SIR) gene, SIR2. SIR4, essential for other silenced loci, paradoxically inhibits rDNA silencing. In this study, we elucidate a regulatory mechanism for rDNA silencing based on the finding that rDNA silencing strength directly correlates with cellular Sir2 protein levels. The endogenous level of Sir2p was shown to be limiting for rDNA silencing. Furthermore, small changes in Sir2p levels altered rDNA silencing strength. In rDNA silencing phenotypes, sir2 mutations were shown to be epistatic to sir4 mutations, indicating that SIR4 inhibition of rDNA silencing is mediated through SIR2. Furthermore, rDNA silencing is insensitive to SIR3 overexpression, but is severely reduced by overexpression of full-length Sir4p or a fragment of Sir4p that interacts with Sir2p. This negative effect of SIR4 overexpression was overridden by co-overexpression of SIR2, suggesting that SIR4 directly inhibits the rDNA silencing function of SIR2. Finally, genetic manipulations of SIR4 previously shown to promote extended life span also resulted in enhanced rDNA silencing. We propose a simple model in which telomeres act as regulators of rDNA silencing by competing for limiting amounts of Sir2 protein. PMID:9649515

  7. James Hillman (1926-2011).

    PubMed

    Stern, E Mark

    2012-09-01

    Presents an obituary for James Hillman. James Hillman, the third child of Madeline and Julian Hillman, died of metastatic bone cancer at his home in Thompson, Connecticut, on October 27, 2011. The parent of "archetypal psychology," he was born on April 12, 1926, at the Breakers, a then-opulent hotel founded by his family that overlooked the boardwalk and beach in Atlantic City, New Jersey. With an extensive footing in the classics and classical humanism, Jim established the foundations for his emerging archetypal psychology. With archetypal psychology, he was to move away from a dependence on the concept of a personal ego in favor of larger sources that relied on his notion of variegated identity. He proposed a profusion of mythical images that emerge under the rubric of "soul." Soul stands as an appellation indicating a deepening of psychic events, such as when dreams, chaos, and "pathologizing" (the struggles of imagination) are most experienced. For Hillman, psychology could not be taken as a separate discipline isolated from mythology, literature, art, philosophy, politics, religion, natural science, and the ordinary affairs of individuals. Hillman envisioned archetypes as processes that bear evidence to personal suffering and, in so doing, prompt the expansion of compassion. In 1975, Jim was nominated for a Pulitzer Prize for his book Re-Visioning Psychology (Harper & Row). In addition to many other citations, Jim had the high honor in 2001 of receiving the Medal of the Presidency of the Italian Republic. PMID:22963419

  8. [Sir Francis Galton: the father of eugenics].

    PubMed

    Aubert-Marson, Dominique

    2009-01-01

    Not only was Sir Francis Galton a famous geographer and statistician, he also invented "eugenics" in 1883. Eugenics, defined as the science of improving racial stock, was developed from a new heredity theory, conceived by Galton himself, and from the evolution theory of Charles Darwin, transposed to human society by Herbert Spencer. Galton's eugenics was a program to artificially produce a better human race through regulating marriage and thus procreation. Galton put particular emphasis on "positive eugenics", aimed at encouraging the physically and mentally superior members of the population to choose partners with similar traits. In 1904, he presented his ideas in front of a vast audience of physicians and scientists in London. His widely-publicized lecture served as the starting point for the development of eugenics groups in Europe and the United States during the first half of the 20th century. PMID:19602363

  9. Sir William Ramsay and the noble gases.

    PubMed

    Davies, Alwyn G

    2012-01-01

    Sir William Ramsay was one of the world's leading scientists at the end of the 19th century, and in a spectacular period of research between 1894 and 1898, he discovered five new elements. These were the noble gases, helium, neon, argon, krypton, and xenon; they added a whole new group to the Periodic Table of the elements, and provided the keystone to our understanding of the electronic structure of atoms, and the way those electrons bind the atoms together into molecules. For this work he was awarded the Nobel Prize in Chemistry in 1904, the first such prize to come to a British subject. He was also a man of great charm, a good linguist, and a composer and performer of music, poetry and song. This review will trace his career, describe his character and give and account of the chemistry which led to the award of the Nobel Prize. PMID:22574384

  10. [Concept of SIRS and severe acute pancreatitis].

    PubMed

    Hirota, Masahiko; Sugita, Hiroki; Maeda, Keisuke; Ichibara, Atsushi; Ogawa, Michio

    2004-11-01

    Acute pancreatitis is a potentially fatal disease, the severity of which ranges from a mild edematous form to a severe necrotizing form. Most patients develop systemic inflammatory response syndrome (SIRS), which is induced by proinflammatory cytokines. The cytokine production can be induced by activation of Toll-like receptor. The breakdown products of the pancreatic and peripancreatic tissues by proteases might be the agonists. Cytokines are supposed to be produced as a biological defense system. However, cytokines may often evoke organ failure and/or immunosuppressive state, if they would be produced excessively. To express this complicated pathologic condition, Ogawa proposed a concept of LISIS(local inflammation-induced systemic immunosuppression syndrome). We have to pay attention to such aspects in the management of this disease. PMID:15552899

  11. Mirror Figuring Techniques of Sir William Herschel

    NASA Astrophysics Data System (ADS)

    Albin, E. F.

    2004-05-01

    Between the years 1773 to 1818, Sir William Herschel constructed dozens of speculum telescope mirrors, with diameters ranging from 6 - 48 inches. Very little, if any, detailed information has ever been published on the specifics of his mirror figuring efforts. The reason for this certainly relates to his desire to closely guard mirror production trade secrets. Upon Herschel's death, all telescope-making documents were passed on to his only son, Sir John Herschel. These materials are now in the possession of the British RAS and primarily consist of: a) a four volume series entitled "Experiments on the Construction of Specula," b) a 129 page treaty called "On the Construction of Specula," and c) a 179 page manuscript entitled "Results of Experiments on the Construction of Mirrors." It is suggested that publication was further delayed and then eventually abandoned due to silver-coated glass mirrors coming into favor. A recent investigation by the author, of the unpublished manuscripts on the construction of specula, suggests that Herschel's mirror figuring techniques did not involve any guess work; in fact, his methods were highly refined -- never leaving to chance the evolution of a spherical surface into the required paraboloid. At the heart of Herschel's figuring techniques were a series of aperture diaphragms (similar to the Couder masks used by modern telescope makers) that were placed over the mirror, which allowed for the precise determination of its curvature at various predefined zones. With this information, Herschel was able to vary his figuring strokes with his polishing tool accordingly. In addition, all mirrors were subsequently "star tested," sometimes with aperture diaphragms in place, allowing for field examination of the mirror's "distinctness" or performance. Double stars and the planet Saturn were favorite targets used to analyze and then correct a mirror's figure.

  12. James Moffett's Legacy to "English Journal"

    ERIC Educational Resources Information Center

    Spalding, Elizabeth; Koshnick, Damian C.; Myers, Miles

    2012-01-01

    In this article, the authors look at James Moffett's influence on "English Journal". With the 1968 publication of his companion volumes--"Teaching the Universe of Discourse," which provided the theoretical underpinnings of his practice-oriented, and "A Student-Centered Language Arts Curriculum"--James Moffett (1929-96) became a major influence on…

  13. Pulkkinen receives James B. Macelwane Medal

    NASA Astrophysics Data System (ADS)

    Baker, Daniel N.; Pulkkinen, Tuija I.

    Tuija I. Pulkkinen was awarded the James B. Macelwane Medal at the AGU Spring Meeting Honors Ceremony, which was held on May 27, 1998, in Boston, Massachusetts. The James B. Macelwane Medal recognizes young scientists of outstanding ability who have made significant contributions to the geophysical sciences.

  14. Writing siblings: Alice James and her brothers.

    PubMed

    Hoffman, Anne Golomb

    2015-02-01

    This essay addresses the relationship of writing to embodiment, through representations of bodily sensation and fantasy in the journal of Alice James. It considers Alice James's writing in relation to her two writer brothers, William and Henry, and in light of their father's experiences of impairment and breakdown. PMID:25688678

  15. Henry James on the Art of Acting.

    ERIC Educational Resources Information Center

    Thompson, David W.

    Henry James, the nineteenth-century American novelist, also served on occasion as a theatre critic. Between 1875 and 1890 he reviewed several productions in Boston, New York, London, and Paris for "Atlantic Monthly" and other periodicals. The reviews are of interest because of James' high standards regarding acting and his often devasting comments…

  16. The James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Kalirai, Jason

    2014-07-01

    The James Webb Space Telescope (JWST) will be the most powerful space telescope that we've ever constructed, and it is a critical step towards answering the top science questions outlined in both the 2000 and 2010 Astronomy & Astrophysics Decadal Surveys. In this presentation, I'll first briefly highlight the science capabilities, current status, and science timeline of JWST out to its 2018 launch. I'll then describe several frontier science opportunities that are uniquely enabled by combining JWST's high spatial resolution and unprecedented IR throughput with the Thirty Meter Telescope's spectral capabilities and visible throughput. Like Hubble and current 10 meter telescopes on the ground, the combination of these two facilities will be a great 1-2 punch to usher in a new era in UVOIR astrophysics.

  17. Doctors, disease and James Joyce.

    PubMed

    Kaplan, Robert M

    2008-08-01

    The Irish author James Joyce is regarded as the greatest modernist writer of his time. His works, notably The Dead, A Portrait of the Artist as a Young Man, Ulysses and Finnegans Wake--are intensely autobiographic including meticulous descriptions of illness and states of health--no surprise in view of Joyce's medical history and hypochondria. The Dead revolves around the tragic love of a doomed tubercular youth. Ulysses has a graphic description of Mary Joyce-s death, a funeral and a birth; Stephen Dedalus, the character based on Joyce, attends a drinking session with medical students at the lying-in hospital just as Joyce had done as a student; references to syphilis, alcoholism and other illnesses abound. PMID:18704219

  18. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2011-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes, and is currently the largest scientific project under construction in the United States. It will be a large (6.6m) cold (50K) telescope launched into orbit around the second Earth-Sun Lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. Science with the James Webb Space Telescope falls into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and black holes within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. I will conclude the talk with a description of recent technical progress in the construction of the observatory.

  19. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2011-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes, and is currently the largest scientific project under construction in the United States. It will be a large (6.6m) cold (50K) telescope launched in about 5 years into orbit around the second Earth-Sun Lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. Science with the James Webb Space Telescope falls into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and black holes within them evolved from the epoch of reionization to the present. The Birth of Stars and Proto planetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. I will conclude the talk with a description of recent technical progress in the construction of the observatory.

  20. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2011-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes, and is currently the largest scientific project under construction in the United States. It will be a large (6.6m) cold (50K) telescope launched in about 5 years into orbit around the second Earth-Sun Lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. Science with the James Webb Space Telescope falls into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and black holes within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. I will conclude the talk with a description of recent technical progress in the construction of the observatory.

  1. A Curriculum for Peace: A Conversation with Sir John Daniel.

    ERIC Educational Resources Information Center

    Perkins-Gough, Deborah; Lindfors, Sally; Ernst, Don

    2002-01-01

    Interview with Sir John Daniel, Assistant Director-General for Education of the United Nations Educational, Scientific, and Cultural Organization (UNESCO). Discusses UNESCO's role in promoting a peace curriculum in schools throughout the world. (PKP)

  2. Sir John Cornforth AC CBE FRS: his synthetic work.

    PubMed

    Purchase, Rupert; Hanson, James R

    2015-01-01

    Sir John Cornforth work on the synthesis of cholesterolandpenicillamine, on the chemistry of oxazoles, the stereochemistry of the synthesis of alkenes, the synthesis of abscisic acid and of dibenzophospholes as mimics of enzyme action, is reviewed. PMID:26601337

  3. Was Sir William Crookes epistemically virtuous?

    PubMed

    Kidd, Ian James

    2014-12-01

    The aim of this paper is to use Sir William Crookes' researches into psychical phenomena as a sustained case study of the role of epistemic virtues within scientific enquiry. Despite growing interest in virtues in science, there are few integrated historical and philosophical studies, and even fewer studies focussing on controversial or 'fringe' sciences where, one might suppose, certain epistemic virtues (like open-mindedness and tolerance) may be subjected to sterner tests. Using the virtue of epistemic courage as my focus, it emerges that Crookes' psychical researches were indeed epistemically courageous, but that this judgment must be grounded in sensitivity to the motivational complexity and context-sensitivity of the exercise of epistemic virtues. The paper then considers Crookes' remarks on the relationship between epistemic virtuousness and the intellectual integrity and public duties of scientists, thereby placing epistemic virtues in the context of wider debates about the authority of science in late modern societies. I conclude that Crookes' researches into psychical phenomena offer instructive lessons for historians of science and virtue epistemologists concerning the complexity and contextuality of epistemic virtues, and the profitable forms that future studies of virtues in science could take. PMID:25091260

  4. Shuttle Imaging Radar-A (SIR-A) experiment

    NASA Technical Reports Server (NTRS)

    Elachi, C. (Editor); Cimino, J. B. (Editor)

    1982-01-01

    The SIR-A experiment was conducted in order to acquire radar data over a variety of regions to further understanding of the radar signatures of various geologic features. The capability of the Shuttle as a scientific platform for observation of the Earth's resources was assessed. The SIR-A sensor operated nominally and the full data acquisition capacity of the optical recorder was used.

  5. James Johnson on Asteroid Mission Simulation Testing

    NASA Video Gallery

    NASA Public Affairs Officer Brandi Dean talks to James Johnson, the test director for a simulated mission to an asteroid taking place at the Space Vehicle Mockup Facility at the Johnson Space Cente...

  6. The Teaching Spirit of William James

    ERIC Educational Resources Information Center

    Korn, James H.

    2003-01-01

    William James provided not only practical advice to teachers but also wisdom concerning values in living. Statements from his students show his qualities as a teacher, although some of his statements convey his ambivalence about teaching.

  7. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Nowak, Maria; Eichorn, William; Hill, Michael; Hylan, Jason; Marsh, James; Ohl, Raymond; Sampler, Henry; Wright, Geraldine; Crane, Allen; Herrera, Acey; Quigley, Robert; Jetten, Mark; Young, Philip

    2007-01-01

    The James Webb Space Telescope (JWST) is a 6.6m diameter, segmented, deployable telescope for cryogenic IR space astronomy (approx.40K). The JWST Observatory architecture includes the Optical Telescope Element and the Integrated Science Instrument Module (ISIM) element that contains four science instruments (SI) including a Guider. The ISIM optical metering structure is a roughly 2.2x1.7x2.2mY, asymmetric frame that is composed of carbon fiber and resin tubes bonded to invar end fittings and composite gussets and clips. The structure supports the SIs, isolates the SIs from the OTE, and supports thermal and electrical subsystems. The structure is attached to the OTE structure via strut-like kinematic mounts. The ISM structure must meet its requirements at the approx.40K cryogenic operating temperature. The SIs are aligned to the structure s coordinate system under ambient, clean room conditions using laser tracker and theodolite metrology. The ISM structure is thermally cycled for stress relief and in order to measure temperature-induced mechanical, structural changes. These ambient-to-cryogenic changes in the alignment of SI and OTE-related interfaces are an important component in the JWST Observatory alignment plan and must be verified.

  8. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2009-01-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these for science themes, JWST will be a large (6.6m) cold (50K) telescope launched to the second Earth-Sun Lagrange point early in the next decade. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA. JWST will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. I review the status and capabilities of the observatory and instruments in the context of the major scientific goals.

  9. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2012-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes. It will be a large (6.6m) cold (SDK) telescope launched into orbit around the second Earth-Sun Lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. The science goals for JWST include the formation of the first stars and galaxies in the early universe; the chemical, morphological and dynamical buildup of galaxies and the formation of stars and planetary systems. Recently, the goals have expanded to include studies of dark energy, dark matter, active galactic nuclei, exoplanets and Solar System objects. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Near-Infrared Imager and Slitless Spectrograph will cover the wavelength range 0.6 to S microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. The observatory is confirmed for launch in 2018; the design is complete and it is in its construction phase. Recent progress includes the completion of the mirrors, the delivery of the first flight instruments and the start of the integration and test phase.

  10. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Clampin, Mark

    2011-01-01

    The James Webb Space Telescope (JWST) is a large, infrared-optimized space telescope. JWST's primary science goal is to detect and characterize the first galaxies. It will also study the assembly of galaxies, star formation, and the formation of evolution of planetary systems. The observatory has a large primary mirror 6.5 meter in diameter, designed to deliver high angular resolution in the infrared, combined with a large collecting area. The telescope optics are designed and fabricated to operate at the cryogenic temperatures (,...,40 k) required for an IR optimized telescope. The primary mirror is also a segmented mirror architecture. The observatory is designed to achieve cryogenic operating temperature via passive cooling, facilitated by a five-layer sunshield which keeps the telescope in the sun's shadow. Since the observatory dimensions exceed the Ariane 5 fairing size, the observatory has to be stowed for launch and deployed following launch. The observatory will be launched into an L2 orbit that provides continuous science operations and a benign thermal environment for optical stability.

  11. Hydrodynamics of internal solitons and a comparison of SIR-A and SIR-B data with ocean measurements

    NASA Technical Reports Server (NTRS)

    Apel, J. R.; Gasparovic, R. F.; Thompson, D. R.

    1986-01-01

    Large internal solitary waves have been observed by Shuttle SIR-A and SIR-B at locations in the Andaman Sea and the New York Bight. Satellite imagery and oceanographic measurements are used in conjunction with hydrodynamic interaction and electromagnetic scattering models to estimate the expected SAR image intensity modulations associated with the internal waves. There is reasonable agreement between the predicted and observed internal wave signatures.

  12. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2007-01-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these four science themes, JWST will be a large (6.6m) cold (50K) telescope launched to the second Earth-Sun Lagrange point early in the next decade. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA. JWST will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. In this paper, the status and capabilities of the observatory and instruments in the context of the major scientific goals are reviewed.

  13. The James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Gardner, J.

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these four science themes, JWST will be a large (6.5m) cold (50K) telescope launched to the second Earth-Sun Lagrange point early in the next decade. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA. JWST will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy between 5 and 29 microns. JWST is a facility-class mission, so most of the observing time will be allocated to investigators from the international astronomical community through competitively-selected proposals.

  14. The James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Gardner, J. P.

    2009-12-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these four science themes, JWST will be a large (6.5m) cold (50K) telescope launched to the second Earth-Sun Lagrange point early in the next decade. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA. JWST will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will operate within the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy between 5 and 29 microns. The scientific investigations described here define the measurement capabilities of the telescope, but they do not imply that those particular observations will be made. JWST is a facility-class mission, so most of the observing time will be allocated to investigators from the international astronomical community through competitively-selected proposals.

  15. St. James marine terminal facility description

    SciTech Connect

    Not Available

    1993-10-01

    The US Department of Energy (DOE) currently owns and operates a marine terminal on the west bank of the Mississippi River at St. James, Louisiana. The St. James facility was constructed by the Department to provide marine services associated with the fill and drawdown of the Strategic Petroleum Reserve (SPR) crude oil storage facilities located at Bayou Choctaw and Weeks Island, Louisiana. Although strategic to the mission of the SPR in the event of a national emergency, the St. James terminal is situated such that it has a high potential to also serve the commercial industry`s needs for crude oil terminalling and storage. The St. James terminal is located approximately 45 miles west of New Orleans and 30 miles southeast of Baton Rouge, and approximately 160 miles upstream from the mouth of the Mississippi River. Construction of the St. James terminal was initiated in 1978 and was completed in 1980. Since then, the terminal has received and transferred over 125 million barrels of crude oil to the SPR sites for storage. For crude oil distribution, the St. James terminal was connected to the neighboring LOCAP terminal by a 0.1 mile 36-inch pipeline in 1981 and to the Capline terminal by a 0.5 mile 30-inch pipeline in 1988. The terminal also has a 30-inch pipeline connection to the Koch oil terminal which was used for initial fill purposes; however, this pipeline has been disconnected and is currently inactive. A complete description of the St. James terminal facilities, operational capabilities, operational certifications, and future Government requirements are presented in Sections 2, 3, 4, and 5 respectively.

  16. Obituary: James Houck (1940 - 2015)

    NASA Astrophysics Data System (ADS)

    Weedman, Daniel; Barry, Donald; Soifer, Thomas

    James R. Houck, the leading figure in developing infrared spectroscopy for astrophysics, died in Ithaca, NY, on September 18, 2015, at age 74 from complications of Alzheimer's Disease. He was born on October 5, 1940, in Mobile, Alabama, but lived much of his early life in Pittsburgh, Pennsylvania, where he received his undergraduate degree from Carnegie Institute of Technology. Jim spent his scientific career at Cornell University. He came to Cornell as a physics graduate student in 1962 and remained until his retirement as the Kenneth A. Wallace Professor of Astronomy in 2012. His only year away from Ithaca was as a Guggenheim Fellow at Caltech, and he declined job offers from other universities because of his opinion that Ithaca provided the best environment for raising his family. His passion for learning, doing, and teaching science by building instruments and understanding physics led to great benefits for his students and astronomy colleagues. After receiving his PhD in condensed matter physics, he changed fields to work in astronomy at Cornell. He first collaborated with colleague Martin Harwit to develop a rocket program at Cornell for infrared observations and made numerous treks to the White Sands Missile Range flying payloads on Aerobee sounding rockets. Jim emphasized building spectrographs and making pioneering observations with ground based, airborne, and rocket-borne infrared instrumentation. Jim flew on every airplane NASA provided for astronomy. Those were pioneering times. One of his survival stories was of the Learjet in which both engines flamed out over the Pacific when the pilot did a celebratory barrel role after successful completion of their observations. His observations with rockets and airplanes were primarily of a variety of Galactic objects, including planetary nebulae, HII regions, and stars. But the most notable was an observation on the Convair 990 that produced a prescient discovery paper in 1973 led by Jim which discovered bound

  17. The James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Gardner, Jonathan P.; Mather, John C.; Clampin, Mark; Doyon, Rene; Greenhouse, Matthew A.; Hammel, Heidi B.; Hutchings, John B.; Jakobsen, Peter; Lilly, Simon J.; Long, Knox S.; Lunine, Jonathan I.; McCaughrean, Mark J.; Mountain, Matt; Nella, John; Rieke, George H.; Rieke, Marcia J.; Rix, Hans-Walter; Smith, Eric P.; Sonneborn, George; Stiavelli, Massimo; Stockman, H. S.; Windhorst, Rogier A.; Wright, Gillian S.

    2006-04-01

    The James Webb Space Telescope (JWST) is a large (6.6 m), cold (<50 K), infrared (IR)-optimized space observatory that will be launched early in the next decade into orbit around the second Earth Sun Lagrange point. The observatory will have four instruments: a near-IR camera, a near-IR multiobject spectrograph, and a tunable filter imager will cover the wavelength range, 0.6 < ; < 5.0 μ m, while the mid-IR instrument will do both imaging and spectroscopy from 5.0 < ; < 29 μ m. The JWST science goals are divided into four themes. The key objective of The End of the Dark Ages: First Light and Reionization theme is to identify the first luminous sources to form and to determine the ionization history of the early universe. The key objective of The Assembly of Galaxies theme is to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present day. The key objective of The Birth of Stars and Protoplanetary Systems theme is to unravel the birth and early evolution of stars, from infall on to dust-enshrouded protostars to the genesis of planetary systems. The key objective of the Planetary Systems and the Origins of Life theme is to determine the physical and chemical properties of planetary systems including our own, and investigate the potential for the origins of life in those systems. Within these themes and objectives, we have derived representative astronomical observations. To enable these observations, JWST consists of a telescope, an instrument package, a spacecraft, and a sunshield. The telescope consists of 18 beryllium segments, some of which are deployed. The segments will be brought into optical alignment on-orbit through a process of periodic wavefront sensing and control. The instrument package contains the four science instruments and a fine guidance sensor. The spacecraft provides pointing, orbit maintenance, and communications. The sunshield

  18. The James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Gardner, Jonathan P.; Mather, John C.; Clampin, Mark; Doyon, Rene; Flanagan, Kathryn A.; Franx, Marijn; Greenhouse, Matthew A.; Hammel, Heidi B.; Hutchings, John B.; Jakobsen, Peter; Lilly, Simon J.; Lunine, Jonathan I.; McCaughrean, Mark J.; Mountain, Matt; Rieke, George H.; Rieke, Marcia J.; Sonneborn, George; Stiavelli, Massimo; Windhorst, Rogier; Wright, Gillian S.

    The James Webb Space Telescope (JWST) is a large (6.6 m), cold (<50 K), infrared (IR)-optimized space observatory that will be launched early in the next decade into orbit around the second Earth-Sun Lagrange point. The observatory will have four instruments: a near-IR camera, a near-IR multi-object spectrograph, and a tunable filter imager that will cover the wavelength range, 0.6 < λ < 5.0 μm, while the mid-IR instrument will do both imaging and spectroscopy from 5.0 < λ < 29 μm. The JWST science goals are divided into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the early universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present day. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems including our own, and investigate the potential for the origins of life in those systems. To enable these science goals, JWST consists of a telescope, an instrument package, a spacecraft, and a sunshield. The telescope primary mirror is made of 18 beryllium segments, some of which are deployed. The segments will be brought into optical alignment on-orbit through a process of periodic wavefront sensing and control. The instrument package contains the four science instruments and a fine guidance sensor. The spacecraft provides pointing, orbit maintenance, and communications. The sunshield provides passive thermal control. The JWST operations plan is based on that used for previous space observatories, and the majority of JWST

  19. A concert of music by Sir William Herschel

    NASA Astrophysics Data System (ADS)

    Hessman, F. V.; Hammer, C.

    2002-01-01

    The Orchester Göttinger Musikfreunde presented an evening of music in the magnificent Aula of the University as one of the social events of the conference. The astronomical highlights of the concert were two symphonic works by Sir William Herschel, including an oboe solo by a member of the LOC (W. Glatzel). This is the text from the concert programme. A recording of the concert is included in this proceedings. Programme --------- Sir William Herschel (1738-1822): Symphony No. 13 in D Major (1762) W. A. Mozart (1756-1791): Piano Concerto No. 27 in B Major (KV 595), C. Hammer (piano) Sir William Herschel (1738-1822): Fragment of an Oboe Concerto in C Major (MS790), W. Glatzel (oboe) J. Haydn (1732-1809): Symphony No. 91 E-flat Major We would like to acknowledge the Sparkasse Göttingen and the Versicherungsgesellschaft Hannover for generously making this concert possible.

  20. The Shuttle Imaging Radar B (SIR-B) experiment report

    NASA Technical Reports Server (NTRS)

    Cimino, Jo Bea; Holt, Benjamin; Richardson, Annie

    1988-01-01

    The primary objective of the SIR-B experiment was to acquire multiple-incidence-angle radar imagery of a variety of Earth's surfaces to better understand the effects of imaging geometry on radar backscatter. A complementary objective was to map extensive regions of particular interest. Under these broad objectives, many specific scientific experiments were defined by the 43 SIR-B Science Team members, including studies in the area of geology, vegetation, radar penetration, oceanography, image analysis, and calibration technique development. Approximately 20 percent of the planned digital data were collected, meeting 40 percent of the scientific objectives. This report is an overview of the SIR-B experiment and includes the science investigations, hardware design, mission scenario, mission operations, events of the actual missions, astronaut participation, data products (including auxiliary data), calibrations, and a summary of the actual coverage. Also included are several image samples.

  1. Plasma biomarkers of SIRS and MODS associated with canine babesiosis.

    PubMed

    Kuleš, J; de Torre-Minguela, C; Barić Rafaj, R; Gotić, J; Nižić, P; Ceron, J J; Mrljak, V

    2016-04-01

    Canine babesiosis is a tick-borne disease caused by the haemoprotozoan parasites of the genus Babesia. Early detection of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) is of major importance in clinical practice for providing information about severity and outcomes of the disease and therapy. Plasma samples were taken at admission from five dogs with uncomplicated babesiosis caused by B. canis canis, five dogs with babesiosis and SIRS, five dogs with babesiosis and MODS, and five healthy dogs. After two-dimensional electrophoresis and capillary reversed - phase liquid chromatography coupled online with tandem mass spectrometry, 68 differentially expressed spots with level of significance P<0.05 were detected between groups. SIRS in babesiosis was characterised by increases in paraoxonase 1 and apoA-I, whereas MODS with decrease of complement inhibitors leading to prolonged complement activation and decrease of vitamin D binding protein due to haemolysis and activation of the coagulation cascade. PMID:27033937

  2. SIR-2 Data Normalization and Integration with M3 Data

    NASA Astrophysics Data System (ADS)

    Grumpe, A.; Felder, M. P.; Wöhler, C.; Mall, U.

    2013-09-01

    The point spectrometer SIR-2 on Chandrayaan-1 provided radiance spectra integrated over circular footprints of 200 m diameter in the wavelength range 934-2410.8 nm in 256 channels [1]. To analyze SIR-2 reflectance spectra in their spatial context, a coregistration to Chandrayaan-1 M³ hyperspectral images [2] as well as a correction for topography and thermal emission are inevitable. The thermal and topographic correction procedure is based on the surface temperature and a digital elevation model (DEM) inferred from M³ data. The corrected reflectance spectra are then normalized to a standard illumination and viewing geometry.

  3. Performance of the SIR-B digital image processing subsystem

    NASA Technical Reports Server (NTRS)

    Curlander, J. C.

    1986-01-01

    A ground-based system to generate digital SAR image products has been developed and implemented in support of the SIR-B mission. This system is designed to achieve the maximum throughput while meeting strict image fidelity criteria. Its capabilities include: automated radiometric and geometric correction of the output imagery; high-precision absolute location without tiepoint registration; filtering of the raw data to remove spurious signals from alien radars; and automated catologing to maintain a full set of radar and image production facility in support of the SIR-B science investigators routinely produces over 80 image frames per week.

  4. William james, gustav fechner, and early psychophysics.

    PubMed

    Hawkins, Stephanie L

    2011-01-01

    American psychologist and philosopher William James devoted the entirety of his career to exploring the nature of volition, as expressed by such phenomena as will, attention, and belief. As part of that endeavor, James's unorthodox scientific pursuits, from his experiments with nitrous oxide and hallucinogenic drugs to his investigation of spiritualist mediums, represent his attempt to address the "hard problems" of consciousness for which his training in brain physiology and experimental psychology could not entirely account. As a student, James's reading in chemistry and physics had sparked his interest in the concepts of energy and force, terms that he later deployed in his writing about consciousness and in his arguments against philosophical monism and scientific materialism, as he developed his "radically empiricist" ideas privileging discontinuity and plurality. Despite James's long campaign against scientific materialism, he was, however, convinced of the existence of a naturalistic explanation for the more "wayward and fitful" aspects of mind, including transcendent experiences associated with hysteria, genius, and religious ecstasy. In this paper, I examine aspects of James's thought that are still important for contemporary debates in psychology and neuroscience: his "transmission theory" of consciousness, his ideas on the "knowing of things together," and, finally, the related concept of "the compounding of consciousness," which postulates the theoretical possibility for individual entities within a conscious system of thought to "know" the thoughts of others within the system. Taken together, these ideas suggest that James, in spite of, or perhaps because of, his forays into metaphysics, was working toward a naturalistic understanding of consciousness, what I will term a "distributive model," based on his understanding of consciousness as an "awareness" that interacts dynamically within, and in relation to, its environment. PMID:22016738

  5. Obituary: James Houck (1940 - 2015)

    NASA Astrophysics Data System (ADS)

    Weedman, Daniel; Barry, Donald; Soifer, Thomas

    James R. Houck, the leading figure in developing infrared spectroscopy for astrophysics, died in Ithaca, NY, on September 18, 2015, at age 74 from complications of Alzheimer's Disease. He was born on October 5, 1940, in Mobile, Alabama, but lived much of his early life in Pittsburgh, Pennsylvania, where he received his undergraduate degree from Carnegie Institute of Technology. Jim spent his scientific career at Cornell University. He came to Cornell as a physics graduate student in 1962 and remained until his retirement as the Kenneth A. Wallace Professor of Astronomy in 2012. His only year away from Ithaca was as a Guggenheim Fellow at Caltech, and he declined job offers from other universities because of his opinion that Ithaca provided the best environment for raising his family. His passion for learning, doing, and teaching science by building instruments and understanding physics led to great benefits for his students and astronomy colleagues. After receiving his PhD in condensed matter physics, he changed fields to work in astronomy at Cornell. He first collaborated with colleague Martin Harwit to develop a rocket program at Cornell for infrared observations and made numerous treks to the White Sands Missile Range flying payloads on Aerobee sounding rockets. Jim emphasized building spectrographs and making pioneering observations with ground based, airborne, and rocket-borne infrared instrumentation. Jim flew on every airplane NASA provided for astronomy. Those were pioneering times. One of his survival stories was of the Learjet in which both engines flamed out over the Pacific when the pilot did a celebratory barrel role after successful completion of their observations. His observations with rockets and airplanes were primarily of a variety of Galactic objects, including planetary nebulae, HII regions, and stars. But the most notable was an observation on the Convair 990 that produced a prescient discovery paper in 1973 led by Jim which discovered bound

  6. A Cross-Institutional Factor Structure Replication of the Michigan State University Sirs Faculty Evaluation Model

    ERIC Educational Resources Information Center

    Arreola, Raoul A.

    1973-01-01

    Determines that the factor structure of the instructional model measured by the Michigan State University Student Instructional Rating System (SIRS) form could be replicated by an adapted version of the SIRS instrument at Florida State University. (Author)

  7. 76 FR 12295 - James Luehman; Denial of Petition for Rulemaking

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... REGULATORY COMMISSION 10 CFR Part 50 James Luehman; Denial of Petition for Rulemaking AGENCY: Nuclear... Commission (NRC or the Commission) is denying a petition for rulemaking (PRM) submitted by James Luehman...

  8. William James, Philosophical Father of Experience-Based Education.

    ERIC Educational Resources Information Center

    Donaldson, George W.; Vinson, Richard

    1979-01-01

    The article briefly describes the life of William James, nineteenth-century philosopher and psychologist, noting the development of his pragmatist philosophy. The article uses James' work and ideas to support 11 principles of contemporary experience-based education. (SB)

  9. Speculation on Curriculum from the Perspective of William James.

    ERIC Educational Resources Information Center

    Shubert, William H; Zissis, Georgiana

    1988-01-01

    This article discusses the implications for curriculum theory, research, and practice of William James' thought. Also considered is the question of what curriculum theory and research might be like if James had garnered greater influence than Thorndike. (IAH)

  10. On the Shoulders of Sir Isaac Newton and Arthur Storer

    ERIC Educational Resources Information Center

    Martin, Helen E.; Evans-Gondo, Bonita

    2013-01-01

    Helen E. Martin, the author of this article, is a retired National Board Certified Teacher who has been researching Sir Isaac Newton's unpublished manuscripts for over three decades. While researching the work of Newton, a teacher she was mentoring asked for some hands-on activities to study planetary motion. The description of the activity…

  11. Why Creativity Now? A Conversation with Sir Ken Robinson

    ERIC Educational Resources Information Center

    Azzam, Amy M.

    2009-01-01

    In this interview, creativity expert Sir Ken Robinson makes the case for creativity as the crucial 21st-century skill. Genuine creative processes involve critical thinking as well as imaginative insights and fresh ideas. Also, creativity is a process, not a single event, one that requires continual evaluation. It's about everyone, it's a function…

  12. Ready Reference Tools: EBSCO Topic Search and SIRS Researcher.

    ERIC Educational Resources Information Center

    Goins, Sharon; Dayment, Lu

    1998-01-01

    Discussion of ready reference and current events collections in high school libraries focuses on a comparison of two CD-ROM services, EBSCO Topic Search and the SIRS Researcher. Considers licensing; access; search strategies; viewing articles; currency; printing; added value features; and advantages of CD-ROMs. (LRW)

  13. Sir William Johnson and the Indians of New York.

    ERIC Educational Resources Information Center

    Hamilton, Milton W.

    In order to make the vast literature about the history of Indian and white relations in New York readily accessible to teachers, students, and general readers, this booklet brings together the main points of the relationship between the Indians and Sir William Johnson. Johnson is a key figure in the Indian story of New York state during the 1770s.…

  14. Neuro syphilis: Portrayals by Sir Arthur Conan Doyle

    PubMed Central

    Somasundaram, O.

    2009-01-01

    The developments in neuro syphilis in the 19th century are integral parts of the history of psychiatry. The delineation of various aspects of neuro syphilis by Sir Arthur Conan Doyle in three of his stories is discussed in brief. PMID:19881059

  15. James Joyce: steps towards a diagnosis.

    PubMed

    Lyons, J B

    2000-12-01

    Authors whose scholarship is in the golden realm of English literature have not hesitated to make pronouncements on James Joyce's health. A publication in this genre claims he had tabes dorsalis. One feels that an authoritative comment, accepting or rejecting a diagnosis of neurosyphilis, should be provided by the Journal of the History of the Neurosciences. PMID:11232371

  16. The Religion Journalism of James Gordon Bennett.

    ERIC Educational Resources Information Center

    Buddenbaum, Judith M.

    A study was conducted to examine the journalism work of James Gordon Bennett, who founded the "New York Herald" in the 1830s, and to determine the nature of his coverage of religion before, during, and after the "Moral War" waged in 1840 against Bennett's popular newspaper. In addition, the study analyzed what Bennett's religion coverage reveals…

  17. James Bernard Russell: Scholar, collaborator, mentor

    Technology Transfer Automated Retrieval System (TEKTRAN)

    At the time of his untimely death in 2009, ARS scientist Dr. James B. Russell had established himself as the premier rumen microbiologist of his generation. Dr. Russell’s many contributions to the field, including much of the early work on the Cornell Net Carbohydrate System model, were the product ...

  18. The James Bay Project: Reaction or Action?

    ERIC Educational Resources Information Center

    Mackwood, Gae

    1991-01-01

    Discusses the plan to restructure northern Quebec's landscape through the James Bay hydroelectric project. Suggests that the project offers opportunities to study development versus preservation, federal versus provincial powers, and the conflict between business and Native communities. Explores the need to teach students to care about social…

  19. Milestone reached for James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Banks, Michael

    2016-03-01

    The primary mirror for the James Webb Space Telescope (JWST) - the successor to the Hubble Space Telescope - is complete after engineers at NASA's Goddard Space Flight Center in Maryland, US, put in place the craft's 18th and final mirror segment.

  20. Astronaut James Buchli wearing extravehicular mobility unit

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Astronaut James F. Buchli, wearing an extravehicular mobility unit (EMU), is about to be submerged in the weightless environment training facility (WETF) to simulate a contingency extravehicular activity (EVA) for STS 61-A. In this portrait view, Buchli is wearing a communications carrier assembly (CCA).

  1. Low carbon dialysis for James Paget.

    PubMed

    2010-09-01

    ELGA Process Water explains how it provided a new water purification system for the renal dialysis unit at the James Paget University Hospital in Great Yarmouth that not only delivers the required water quality, and meets Renal Association guidelines on water treatment plants, but will also help reduce the acute healthcare facility's carbon footprint. PMID:20882912

  2. James Madison and the Constitutional Convention.

    ERIC Educational Resources Information Center

    Scanlon, Thomas M.

    1987-01-01

    Part 1 of this three-part article traces James Madison's life and focuses primarily on those events that prepared him for leadership in the U.S. Constitutional Convention of 1787. It describes his early love of learning, education, and public service efforts. Part 2 chronicles Madison's devotion to study and preparation prior to the Constitutional…

  3. William James Sidis, The Broken Twig

    ERIC Educational Resources Information Center

    Montour, Kathleen

    1977-01-01

    By presenting cases of prodigies who entered college as early as William James Bidis but who succeeded, this paper attempts to dissuade the public from its opposition to educational acceleration for precocious children, to which the "Sidis fallacy" has helped give rise. (Author)

  4. A Reflective Conversation with James H. Borland

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Moore, Tammy-Lynne; Borland, James H.

    2014-01-01

    James H. Borland, Ph.D. is Professor of Education in the Department of Curriculum and Teaching at Teachers College, Columbia University in New York City. In this reflective conversation, he reflects on his experiences in an urban environment and the current challenges in gifted education. He argues for ongoing diagnosis of learners' needs…

  5. 33 CFR 147.817 - Sir Douglas Morpeth Tension Leg Platform safety zone.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Sir Douglas Morpeth Tension Leg... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.817 Sir Douglas Morpeth Tension Leg Platform safety zone. (a) Description. The Sir Douglas Morpeth Tension Leg Platform...

  6. The Student Instructional Report for Distance Education: e-SIR II

    ERIC Educational Resources Information Center

    Pike, Gary R.

    2004-01-01

    Recently the Educational Testing Service (ETS) has modified its Student Instructional Report II (SIR II) for use in online distance education courses. The SIR II is a second-generation survey based on more than thirty years of experience with student evaluations (Centra, 1998; Centra and Gaubatz, n.d.). The e-SIR II is based on the highly…

  7. Reflection on the "New Dynamics" of Distance Education: An Interview with Sir John Daniel

    ERIC Educational Resources Information Center

    Latchem, Colin

    2012-01-01

    This article presents an interview with Sir John Daniel outgoing President and CEO of the Commonwealth of Learning. Sir John Daniel's term as President and Chief Executive Officer of the Commonwealth of Learning (COL) ended on May 31, 2012. Readers of "Distance Education" will know of Sir John's work at the Tele-universite (Directeur des Etudes,…

  8. 7. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. John and James Dobson Carpet Mill, East and West Parcels, May 17, 1926, (John and James Dobson, Inc. East Falls, Aero Service Corp., Neg. No. 5986, May 17, 1926, Free Library of Philadelphia, Print Collection). - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  9. 77 FR 25592 - Drawbridge Operation Regulations; James River, Hopewell, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; James River, Hopewell, VA AGENCY... Memorial Bridge, at mile 65.0, across the James River, at Hopewell, VA. This deviation is necessary to... schedule, the SR 156/Benjamin Harrison Memorial Bridge, at mile 65.0, across the James River, at...

  10. The Darwinian Center to the Vision of William James.

    ERIC Educational Resources Information Center

    Bredo, Eric

    The essence of William James's vision can sometimes be hard to discover due to emotional volatility and exploratory impulsiveness. On the other hand, beneath James's apparent inconsistency was a constancy of purpose that can be easily underestimated. This paper argues that the center of James's vision lay in an interpretation of Darwinism. By…

  11. God, James Watt, and the public's land

    SciTech Connect

    Wolf, R.

    1981-05-01

    The political career of James Watt, Secretary of the Interior, is chronicled. His current reputation as archenemy of the environmental movement is largely the outgrowth of three and a half years of activity on behalf of the Mountain States Legal Foundation. Since taking office in January 1981, Watt has moved swiftly to impose his individual standards on USDI. Various programs and agencies are being terminated, and public lands may soon be open for mineral and energy exploitation. (7 drawings, 1 photo)

  12. Diversity in the Sir2 family of protein deacetylases.

    PubMed

    Buck, Stephen W; Gallo, Christopher M; Smith, Jeffrey S

    2004-06-01

    The silent information regulator (Sir2) family of protein deacetylases (Sirtuins) are nicotinamide adenine dinucleotide (NAD)(+)-dependent enzymes that hydrolyze one molecule of NAD(+) for every lysine residue that is deacetylated. The Sirtuins are phylogenetically conserved in eukaryotes, prokaryotes, and Archeal species. Prokaryotic and Archeal species usually have one or two Sirtuin homologs, whereas eukaryotes typically have multiple versions. The founding member of this protein family is the Sir2 histone deacetylase of Saccharomyces cerevisiae, which is absolutely required for transcriptional silencing in this organism. Sirtuins in other organisms often have nonhistone substrates and in eukaryotes, are not always localized in the nucleus. The diversity of substrates is reflected in the various biological activities that Sirtuins function, including development, metabolism, apoptosis, and heterochromatin formation. This review emphasizes the great diversity in Sirtuin function and highlights its unusual catalytic properties. PMID:14742637

  13. Stability analysis of the Euler discretization for SIR epidemic model

    SciTech Connect

    Suryanto, Agus

    2014-06-19

    In this paper we consider a discrete SIR epidemic model obtained by the Euler method. For that discrete model, existence of disease free equilibrium and endemic equilibrium is established. Sufficient conditions on the local asymptotical stability of both disease free equilibrium and endemic equilibrium are also derived. It is found that the local asymptotical stability of the existing equilibrium is achieved only for a small time step size h. If h is further increased and passes the critical value, then both equilibriums will lose their stability. Our numerical simulations show that a complex dynamical behavior such as bifurcation or chaos phenomenon will appear for relatively large h. Both analytical and numerical results show that the discrete SIR model has a richer dynamical behavior than its continuous counterpart.

  14. Nuclear export modulates the cytoplasmic Sir2 homologue Hst2

    PubMed Central

    Wilson, Jeanne M; Le, Viet Q; Zimmerman, Collin; Marmorstein, Ronen; Pillus, Lorraine

    2006-01-01

    Modulating transcription factors is crucial to executing sophisticated gene expression programs. The silent information regulator 2 (Sir2) family of NAD-dependent protein deacetylases influences transcription by targeting proteins such as histones, p53 and forkhead-box family transcription factors. Although apparently cytoplasmic, both mammalian SIRT2 and its yeast orthologue Hst2 have been implicated in transcriptional regulation. Here, we show that Hst2 moves between the nucleus and cytoplasm, but is largely cytoplasmic owing to efficient nuclear export. This nuclear exclusion is mediated by the exportin chromosomal region maintenance 1 (Crm1) and a putative leucine-rich nuclear export sequence in Hst2, which overlaps a unique autoregulatory helix. Disruption of Hst2 export shows that nuclear exclusion inhibits the activity of Hst2 as a transcriptional repressor. Our identification of putative nuclear export sequences in numerous vertebrate SIRT2 proteins shows that active nuclear export can be a conserved mechanism for regulating Sir2 homologues. PMID:17110954

  15. A SIRS epidemic model with infection-age dependence

    NASA Astrophysics Data System (ADS)

    Zhang, Zhonghua; Peng, Jigen

    2007-07-01

    Based on J. Mena-Lorca and H.W. Hethcote's epidemic model, a SIRS epidemic model with infection-age-dependent infectivity and general nonlinear contact rate is formulated. Under general conditions, the unique existence of its global positive solutions is obtained. Moreover, under more general assumptions than the existing, the existence and asymptotical stability of its equilibria are discussed. In the end, the condition on the stability of endemic equilibrium is verified by a special model.

  16. Digital simulation of the SIR-C sensor electronics

    NASA Technical Reports Server (NTRS)

    Klein, Jeffrey D.; Curlander, John C.

    1987-01-01

    In this paper software for simulation of the response of the SIR-C sensor to a point target is described. Synthetic SAR data is generated by passing successive chirps through a simulation of the transmitter electronics, propagation path and receiver electronics. This result is then processed with a digital correlator to yield the point target response of the system. This allows an accurate assessment of the effect of the radar design on the final image product.

  17. Hero or villain?--Sir Richard Doll and occupational cancer.

    PubMed

    Tweedale, Geoffrey

    2007-01-01

    In 2006, the English media broke the story that Sir Richard Doll had for many years been retained on a secret consultancy by Monsanto. Doll's colleagues rushed to his defense, arguing that the story was an unjustified smear on a great man whose work had saved millions of lives. However, Doll's conflicts of interest in his occupational health epidemiology are shown to sit uneasily alongside his more independent smoking/lung cancer studies. PMID:17718181

  18. Sarcophilia, cremation and Sir Henry Thompson (1820-1904).

    PubMed

    Jellinek, E H

    2009-11-01

    Sarcophilia, a neologism for an attachment to human remains, is set in a review of the history of the disposal of the dead. The ancient practice of cremation was relaunched late in the 19th century by the urological surgeon cum social reformer Sir Henry Thompson. He was stimulated by Edwin Chadwick and Charles Dickens, and by Charles Darwin's observations on the earthworm. Sarcophilia is the reason for the controversial Human Tissue Act of 2004. PMID:20029076

  19. A Fractional Order Recovery SIR Model from a Stochastic Process.

    PubMed

    Angstmann, C N; Henry, B I; McGann, A V

    2016-03-01

    Over the past several decades, there has been a proliferation of epidemiological models with ordinary derivatives replaced by fractional derivatives in an ad hoc manner. These models may be mathematically interesting, but their relevance is uncertain. Here we develop an SIR model for an epidemic, including vital dynamics, from an underlying stochastic process. We show how fractional differential operators arise naturally in these models whenever the recovery time from the disease is power-law distributed. This can provide a model for a chronic disease process where individuals who are infected for a long time are unlikely to recover. The fractional order recovery model is shown to be consistent with the Kermack-McKendrick age-structured SIR model, and it reduces to the Hethcote-Tudor integral equation SIR model. The derivation from a stochastic process is extended to discrete time, providing a stable numerical method for solving the model equations. We have carried out simulations of the fractional order recovery model showing convergence to equilibrium states. The number of infecteds in the endemic equilibrium state increases as the fractional order of the derivative tends to zero. PMID:26940822

  20. SIR: Deterministic protein inference from peptides assigned to MS data.

    PubMed

    Matthiesen, Rune; Prieto, Gorka; Amorim, Antonio; Aloria, Kerman; Fullaondo, Asier; Carvalho, Ana S; Arizmendi, Jesus M

    2012-07-16

    Currently the bottom up approach is the most popular for characterizing protein samples by mass spectrometry. This is mainly attributed to the fact that the bottom up approach has been successfully optimized for high throughput studies. However, the bottom up approach is associated with a number of challenges such as loss of linkage information between peptides. Previous publications have addressed some of these problems which are commonly referred to as protein inference. Nevertheless, all previous publications on the subject are oversimplified and do not represent the full complexity of the proteins identified. To this end we present here SIR (spectra based isoform resolver) that uses a novel transparent and systematic approach for organizing and presenting identified proteins based on peptide spectra assignments. The algorithm groups peptides and proteins into five evidence groups and calculates sixteen parameters for each identified protein that are useful for cases where deterministic protein inference is the goal. The novel approach has been incorporated into SIR which is a user-friendly tool only concerned with protein inference based on imports of Mascot search results. SIR has in addition two visualization tools that facilitate further exploration of the protein inference problem. PMID:22626983

  1. Development of SIR-C Ground Calibration Equipment

    NASA Technical Reports Server (NTRS)

    Freeman, A.; Azeem, M.; Haub, D.; Sarabandi, K.

    1993-01-01

    SIR-C/X-SAR is currently scheduled for launch in April 1994. SIR-C is an L-Band and C-Band, multi-polarization spaceborne SAR system developed by NASA/JPL. X- SAR is an X-Band SAR system developed by DARA/ASI. One of the problems involved in calibrating the SIR-C instrument is to make sure that the horizontal (H) and vertical (V) polarized beams are aligned in the azimuth direction, i.e.. that they are pointing in the same direction. This is important if the polarimetric performance specifications for the system are to be met. To solve this problem, we have designed and built a prototype of a low-cost ground receiver capable of recording received power from two antennas, one H-polarized, the other V-polarized. The two signals are mixed to audio then recorded on the left and right stereo channels of a standard audio cassette player. The audio cassette recording can then be played back directly into a Macintosh computer, where it is digitized. Analysis of.

  2. SIR model with general distribution function in the infectious period

    NASA Astrophysics Data System (ADS)

    Gomes, Marcelo F. C.; Gonçalves, Sebastián

    2009-08-01

    The Susceptible-Infected-Removed or SIR model, as it was formulated by Kermack and McKendrick, is the key model for epidemic dynamics. Most applications of such a basic scheme use a constant rate for the removal term. However, that assumption corresponds to the rather unrealistic exponential distribution of infectious times. On the other hand, recent approaches, like numerical simulations, frequently assume a fixed and uniform duration for the infectious state-which is unrealistic too. The extreme assumptions in those different schemes are a hurdle that can frustrate any intention of drawing comparison between results from them. In the present contribution we study the delay equations for the SIR model, comparing the solutions for many typical cases with the simulation counterpart and with the standard SIR model. Using delay equations, where each infected individual is removed at a specific time after being infected, the dynamics for the infected and susceptible agree almost exactly with the numerical implementation. Even in the general case of distributed infective periods, the agreement is excellent.

  3. James Sowerby: meteorites and his meteoritic sword made for the Emperor of Russia, Alexander I, in 1814

    PubMed Central

    Henderson, Paul

    2013-01-01

    James Sowerby included meteorites in his publications of British and exotic natural history and so raised interest in their nature and origins at a time of much debate and involving the President of the Royal Society, Sir Joseph Banks. The celebrations over the defeat of France in 1814 prompted Sowerby to make a sword from the Cape of Good Hope iron meteorite to present to the Russian Emperor, Alexander I, at the time of his state visit to London in June 1814 and in recognition of his achievements in bringing peace to Europe. The story of its attempted presentation, its final reception and the following response, including publications, all helped to increase interest in meteorites and their properties. The rediscovery of the sword after a lengthy disappearance probably brings an unusual saga to a fitting close.

  4. Phylogenetic conservation and homology modeling help reveal a novel domain within the budding yeast heterochromatin protein Sir1.

    PubMed

    Hou, Zhonggang; Danzer, John R; Mendoza, Liza; Bose, Melissa E; Müller, Ulrika; Williams, Barry; Fox, Catherine A

    2009-02-01

    The yeast Sir1 protein's ability to bind and silence the cryptic mating-type locus HMRa requires a protein-protein interaction between Sir1 and the origin recognition complex (ORC). A domain within the C-terminal half of Sir1, the Sir1 ORC interaction region (Sir1OIR), and the conserved bromo-adjacent homology (BAH) domain within Orc1, the largest subunit of ORC, mediate this interaction. The structure of the Sir1OIR-Orc1BAH complex is known. Sir1OIR and Orc1BAH interacted with a high affinity in vitro, but the Sir1OIR did not inhibit Sir1-dependent silencing when overproduced in vivo, suggesting that other regions of Sir1 helped it bind HMRa. Comparisons of diverged Sir1 proteins revealed two highly conserved regions, N1 and N2, within Sir1's poorly characterized N-terminal half. An N-terminal portion of Sir1 (residues 27 to 149 [Sir1(27-149)]) is similar in sequence to the Sir1OIR; homology modeling predicted a structure for Sir1(27-149) in which N1 formed a submodule similar to the known Orc1BAH-interacting surface on Sir1. Consistent with these findings, two-hybrid assays indicated that the Sir1 N terminus could interact with BAH domains. Amino acid substitutions within or near N1 or N2 reduced full-length Sir1's ability to bind and silence HMRa and to interact with Orc1BAH in a two-hybrid assay. Purified recombinant Sir1 formed a large protease-resistant structure within which the Sir1OIR domain was protected, and Orc1BAH bound Sir1OIR more efficiently than full-length Sir1 in vitro. Thus, the Sir1 N terminus exhibited both positive and negative roles in the formation of a Sir1-ORC silencing complex. This functional duality might contribute to Sir1's selectivity for silencer-bound ORCs in vivo. PMID:19029247

  5. Remote sensing of rice fields and sea pollution by SIR-B

    NASA Technical Reports Server (NTRS)

    Fugono, N.; Furuhama, Y.; Takasugi, T.; Okamoto, K.; Fujita, M.; Yoshikado, S.; Masuko, H.; Shinozuka, T.; Inomata, H.; Shiro, I.

    1984-01-01

    Sensor calibration, rice fields, and sea pollution are to be investigated with respect to shuttle imaging radar-B (SIR-B). It is planned that the resolution characteristics of the SIR-B be evaluated, the sidelobe characteristics of the SIR-B be investigated, and the relationship between backscatter cross section and image intensity be established. The microwave-scattering characteristics of rice fields are to be studied using SIR-B data. The possibility of classifying crops from SIR-B data is to be explored. The characteristics of the radar image of oil-like surface films under several sea surface conditions are to be determined. The absolute measurement capability of the sea surface scattering cross section is to be estimated using the SIR.

  6. 10. Historic American Buildings Survey James R. Dunlop, Inc., Photographer, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey James R. Dunlop, Inc., Photographer, n.d. STABLES, INTERIOR DEMOLISHED - Larz Anderson House, 2118 Massachusetts Avenue Northwest, Washington, District of Columbia, DC

  7. 3. Historic American Buildings Survey James R. Dunlop, Inc., Photographer, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey James R. Dunlop, Inc., Photographer, n.d. ARCHWAY TOWARD ENTRANCE - Larz Anderson House, 2118 Massachusetts Avenue Northwest, Washington, District of Columbia, DC

  8. The lymphocyte in immunology: from James B. Murphy to James L. Gowans.

    PubMed

    Silverstein, A M

    2001-07-01

    Between 1912 and 1921, James Murphy established conclusively the role of the lymphocyte in tissue and tumor graft rejection and in protection against infection. Contemporary mainstream immunology paid little attention to these findings, until the lymphocyte was "rediscovered" with the advent of modern cellular immunology after the mid-1950s. PMID:11429534

  9. [Nicolas Dobo and Pierre Jame about the army medical general Lucian Jame].

    PubMed

    Dobo, N; Jame, P

    1996-01-01

    Lucien Jame was born October the 20th 1891 at Gourdon (Lot). State Police Officer's son, he studied in Lyon at the Military Health School. Called up August the 6th 1914, he shined among many fights and wore a lot of medals. After the armistice he defended his thesis upon "Venereal diseases prophylaxis study". March the 9th 1921, medical Officer in South Algeria, he published some original articles regarding to leprosis, tuberculosis and malaria. After a competitive examination in France, Lucien Jame became a Medical Commanding Officer of Military Health Service in Toulouse where Nicolas Dobo was at his disposal. August the 6th 1943, in the same rank in Algier then in Rabat, Lucien Jame reached the top of his career as Chief Executive of Military Health Service. He planed First French army medical operations through Italy, France and Germany battles. "Grand-Officier de la Légion d'honneur", the Army Medical General Lucien Jame retired but kept on with works dedicated to hygiene and preventive medicine till he died, June the 16th, 1969. PMID:11624989

  10. Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.

    PubMed

    Gallagher, Jennifer E G; Babiarz, Joshua E; Teytelman, Leonid; Wolfe, Kenneth H; Rine, Jasper

    2009-04-01

    Heterochromatin renders domains of chromosomes transcriptionally silent and, due to clonal variation in its formation, can generate heritably distinct populations of genetically identical cells. Saccharomyces cerevisiae's Sir1 functions primarily in the establishment, but not the maintenance, of heterochromatic silencing at the HMR and HML loci. In several Saccharomyces species, we discovered multiple paralogs of Sir1, called Kos1-Kos4 (Kin of Sir1). The Kos and Sir1 proteins contributed partially overlapping functions to silencing of both cryptic mating loci in S. bayanus. Mutants of these paralogs reduced silencing at HML more than at HMR. Most genes of the SIR1 family were located near telomeres, and at least one paralog was regulated by telomere position effect. In S. cerevisiae, Sir1 is recruited to the silencers at HML and HMR via its ORC interacting region (OIR), which binds the bromo adjacent homology (BAH) domain of Orc1. Zygosaccharomyces rouxii, which diverged from Saccharomyces after the appearance of the silent mating cassettes, but before the whole-genome duplication, contained an ortholog of Kos3 that was apparently the archetypal member of the family, with only one OIR. In contrast, a duplication of this domain was present in all orthologs of Sir1, Kos1, Kos2, and Kos4. We propose that the functional specialization of Sir3, itself a paralog of Orc1, as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions. PMID:19171939

  11. Selective management of cardiovascular dysfunction in posttraumatic SIRS and sepsis.

    PubMed

    Martin, R Shayn; Kincaid, Edward H; Russell, Hyde M; Meredith, J Wayne; Chang, Michael C

    2005-03-01

    Cardiovascular dysfunction associated with the systemic inflammatory response syndrome (SIRS) is caused by a combination of decreased myocardial contractility and low vascular resistance. The contribution of each of these components can be determined at the bedside, and directed therapy can be appropriately initiated. Over an 8-month period of time, 23 consecutive patients who experienced posttraumatic SIRS while still being monitored with a volumetric pulmonary artery catheter (PAC) were prospectively evaluated. Ventricular pressure-volume diagrams were constructed to quantify myocardial contractility and afterload. In a resuscitation protocol, dobutamine was administered to patients with an isolated decrease in contractility, and dopamine or epinephrine was instituted for the combination of reduced contractility and afterload. Variables describing cardiovascular function were measured at the time of resolution of initial shock resuscitation (BASE), at the onset of SIRS (ONSET), and after administration of inotropic or vasoactive agents (TREAT). ONSET was associated with a significant decrease in left ventricular power (LVP) (362 +/- 96 to 235 +/- 55 mmHg.L/min/m(2), P < 0.00001) and stroke work index (SWI) (4670 +/- 1213 to 3060 +/- 848 mmHg.mL/m, P < 0.00001) from BASE. Sixteen patients (70%) demonstrated predominantly decreased contractility, which returned to near BASE values after the administration of dobutamine. The remaining seven patients (30%) had both decreased contractility and afterload, which was treated with dopamine or epinephrine. LVP and SWI significantly increased (235 +/- 55 to 328 +/- 77 mmHg.L/min/m(2), P < 0.00001, and 3060 +/- 848 to 4554 +/- 1423 mmHg.mL/m(2), P < 0.00001, respectively) on the initiation of directed therapy. Specific cardiovascular abnormalities can be identified at the bedside, and this information can guide pharmacologic management. Directed therapy improves cardiovascular function. PMID:15718916

  12. Involvement of Daphnia pulicaria Sir2 in regulating stress response and lifespan.

    PubMed

    Schumpert, Charles A; Anderson, Craig; Dudycha, Jeffry L; Patel, Rekha C

    2016-02-01

    The ability to appropriately respond to proteotoxic stimuli is a major determinant of longevity and involves induction of various heat shock response (HSR) genes, which are essential to cope with cellular and organismal insults throughout lifespan. The activity of NAD+-dependent deacetylase Sir2, originally discovered in yeast, is known to be essential for effective HSR and longevity. Our previous work on HSR inDaphnia pulicaria indicated a drastic reduction of the HSR in older organisms. In this report we investigate the role of Sir2 in regulating HSR during the lifespan of D. pulicaria. We cloned Daphnia Sir2 open reading frame (ORF) to characterize the enzyme activity and confirmed that the overall function of Sir2 was conserved in Daphnia. The Sir2 mRNA levels increased while the enzyme activity declined with age and considering that Sir2 activity regulates HSR, this explains the previously observed age-dependent decline in HSR. Finally, we tested the effect of Sir2 knockdown throughout adult life by using our new RNA interference (RNAi) method by feeding. Sir2 knockdown severely reduced both the median lifespan as well as significantly increased mortality following heat shock. Our study provides the first characterization and functional study of Daphnia Sir2. PMID:26978617

  13. Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine

    PubMed Central

    Zhu, Anita Y.; Zhou, Yeyun; Khan, Saba; Deitsch, Kirk W.; Hao, Quan; Lin, Hening

    2011-01-01

    Plasmodium falciparum Sir2A (PfSir2A), a member of the sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylases, has been shown to regulate the expression of surface antigens to evade the detection by host immune surveillance. It is thought that PfSir2A achieves this by deacetylating histones. However, the deacetylase activity of PfSir2A is weak. Here we present enzymology and structural evidences supporting that PfSir2A catalyzes the hydrolysis of medium and long chain fatty acyl groups from lysine residues more efficiently. Furthermore, P. falciparum proteins are found to contain such fatty acyl lysine modifications that can be removed by purified PfSir2A in vitro. Together, the data suggest that the physiological function of PfSir2A in antigen variation may be achieved by removing medium and long chain fatty acyl groups from protein lysine residues. The robust activity of PfSir2A would also facilitate the development of PfSir2A inhibitors, which may have therapeutic value in malaria treatment. PMID:21992006

  14. Reversible glutathionylation of Sir2 by monothiol glutaredoxins Grx3/4 regulates stress resistance.

    PubMed

    Vall-Llaura, Núria; Reverter-Branchat, Gemma; Vived, Celia; Weertman, Naomi; Rodríguez-Colman, María José; Cabiscol, Elisa

    2016-07-01

    The regulatory mechanisms of yeast Sir2, the founding member of the sirtuin family involved in oxidative stress and aging, are unknown. Redox signaling controls many cellular functions, especially under stress situations, with dithiol glutaredoxins (Grxs) playing an important role. However, monothiol Grxs are not considered to have major oxidoreductase activity. The present study investigated the redox regulation of yeast Sir2, together with the role and physiological impact of monothiol Grx3/4 as Sir2 thiol-reductases upon stress. S-glutathionylation of Sir2 upon disulfide stress was demonstrated both in vitro and in vivo, and decreased Sir2 deacetylase activity. Physiological levels of nuclear Grx3/4 can reverse the observed post-translational modification. Grx3/4 interacted with Sir2 and reduced it after stress, thereby restoring telomeric silencing activity. Using site-directed mutagenesis, key cysteine residues at the catalytic domain of Sir2 were identified as a target of S-glutathionylation. Mutation of these residues resulted in cells with increased resistance to disulfide stress. We provide new mechanistic insights into Grx3/4 regulation of Sir2 by S-deglutathionylation to increase cell resistance to stress. This finding offers news perspectives on monothiol Grxs in redox signaling, describing Sir2 as a physiological substrate regulated by S-glutathionylation. These results might have a relevant role in understanding aging and age-related diseases. PMID:27085841

  15. Involvement of Daphnia pulicaria Sir2 in regulating stress response and lifespan

    PubMed Central

    Schumpert, Charles A.; Anderson, Craig; Dudycha, Jeffry L.; Patel, Rekha C.

    2016-01-01

    The ability to appropriately respond to proteotoxic stimuli is a major determinant of longevity and involves induction of various heat shock response (HSR) genes, which are essential to cope with cellular and organismal insults throughout lifespan. The activity of NAD+-dependent deacetylase Sir2, originally discovered in yeast, is known to be essential for effective HSR and longevity. Our previous work on HSR in Daphnia pulicaria indicated a drastic reduction of the HSR in older organisms. In this report we investigate the role of Sir2 in regulating HSR during the lifespan of D. pulicaria. We cloned Daphnia Sir2 open reading frame (ORF) to characterize the enzyme activity and confirmed that the overall function of Sir2 was conserved in Daphnia. The Sir2 mRNA levels increased while the enzyme activity declined with age and considering that Sir2 activity regulates HSR, this explains the previously observed age-dependent decline in HSR. Finally, we tested the effect of Sir2 knockdown throughout adult life by using our new RNA interference (RNAi) method by feeding. Sir2 knockdown severely reduced both the median lifespan as well as significantly increased mortality following heat shock. Our study provides the first characterization and functional study of Daphnia Sir2. PMID:26978617

  16. Sir Ronald A. Fisher and the International Biometric Society.

    PubMed

    Billard, Lynne

    2014-06-01

    The year 2012 marks the 50th anniversary of the death of Sir Ronald A. Fisher, one of the two Fathers of Statistics and a Founder of the International Biometric Society (the "Society"). To celebrate the extraordinary genius of Fisher and the far-sighted vision of Fisher and Chester Bliss in organizing and promoting the formation of the Society, this article looks at the origins and growth of the Society, some of the key players and events, and especially the roles played by Fisher himself as the First President. A fresh look at Fisher, the man rather than the scientific genius is also presented. PMID:24499157

  17. Effects of population mixing on the spread of SIR epidemics

    NASA Astrophysics Data System (ADS)

    Fukś, H.; Lawniczak, A. T.; Duchesne, R.

    2006-03-01

    We study dynamics of spread of epidemics of SIR type in a realistic spatially-explicit geographical region, Southern and Central Ontario, using census data obtained from Statistics Canada, and examine the role of population mixing in epidemic processes. Our model incorporates the random nature of disease transmission, the discreteness and heterogeneity of distribution of host population.We find that introduction of a long-range interaction destroys spatial correlations very easily if neighbourhood sizes are homogeneous. For inhomogeneous neighbourhoods, very strong long-range coupling is required to achieve a similar effect. Our work applies to the spread of influenza during a single season.

  18. Color Image of Death Valley, California from SIR-C

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This radar image shows the area of Death Valley, California and the different surface types in the area. Radar is sensitive to surface roughness with rough areas showing up brighter than smooth areas, which appear dark. This is seen in the contrast between the bright mountains that surround the dark, smooth basins and valleys of Death Valley. The image shows Furnace Creek alluvial fan (green crescent feature) at the far right, and the sand dunes near Stove Pipe Wells at the center. Alluvial fans are gravel deposits that wash down from the mountains over time. Several other alluvial fans (semicircular features) can be seen along the mountain fronts in this image. The dark wrench-shaped feature between Furnace Creek fan and the dunes is a smooth flood-plain which encloses Cottonball Basin. Elevations in the valley range from 70 meters (230 feet) below sea level, the lowest in the United States, to more than 3,300 meters (10,800 feet) above sea level. Scientists are using these radar data to help answer a number of different questions about Earth's geology including how alluvial fans form and change through time in response to climatic changes and earthquakes. The image is centered at 36.629 degrees north latitude, 117.069 degrees west longitude. Colors in the image represent different radar channels as follows: red =L-band horizontally polarized transmitted, horizontally polarized received (LHH); green =L-band horizontally transmitted, vertically received (LHV) and blue = CHV.

    SIR-C/X-SAR is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves allowing detailed observations at any time, regardless of weather or sunlight conditions. SIR-C/X-SAR uses three microwave wavelengths: L-band (24 cm), C-band (6 cm) and X-band (3 cm). The multi-frequency data will be used by the international scientific community to better understand the global environment and how it is changing. The SIR-C/X-SAR data, complemented by aircraft and ground

  19. Traffic-driven SIR epidemic spreading in networks

    NASA Astrophysics Data System (ADS)

    Pu, Cunlai; Li, Siyuan; Yang, XianXia; Xu, Zhongqi; Ji, Zexuan; Yang, Jian

    2016-03-01

    We study SIR epidemic spreading in networks driven by traffic dynamics, which are further governed by static routing protocols. We obtain the maximum instantaneous population of infected nodes and the maximum population of ever infected nodes through simulation. We find that generally more balanced load distribution leads to more intense and wide spread of an epidemic in networks. Increasing either average node degree or homogeneity of degree distribution will facilitate epidemic spreading. When packet generation rate ρ is small, increasing ρ favors epidemic spreading. However, when ρ is large enough, traffic congestion appears which inhibits epidemic spreading.

  20. Sir Arthur Conan Doyle: the author was an ophthalmologist.

    PubMed

    Ravin, J G; Migdal, C

    1995-01-01

    Sir Arthur Conan Doyle created the famous detective Sherlock Holmes, and his faithful companion, Dr. Watson. A graduate of the University of Edinburgh Medical School, Doyle (1859-1930) spent nearly ten years practicing medicine. During his years in general practice, Doyle gave particular attention to the eye. Later, he studied ophthalmology in Vienna and spent time with the best known ophthalmologist in Paris. He returned to London and established an ophthalmological office near Harley Street. His literary career soon overtook the medical career, but he made many references to medicine, and to ophthalmology in particular in his writings. PMID:8599161

  1. James R. Wait (1924-1998)

    NASA Astrophysics Data System (ADS)

    Hill, David A.

    James (Jim) R.Wait, a pioneer in electromagnetic theory and applications to geophysical exploration, died of cancer in Tucson, Arizona, on October 1, 1998. At 74, he was still very active and innovative in electromagnetics as Regents Professor Emeritus, University of Arizona, and as a consultant in electrical geophysics. He is survived by his wife, Gertrude; his son, George; his daughter, Laura; and three grandchildren, James, Carolyn, and Connor.Jim was born in Ottawa, Ontario, Canada, on January 23, 1924. He obtained B.A.Sc.and M.A.Sc. degrees in 1948 and 1949, respectively and his Ph.D. degree in 1951, in electrical engineering, all from the University of Toronto. He obtained his “T” in skiing and remained an avid skier all his life. Jim stayed in great shape and always found time to work out despite his busy schedule. I still remember the business trip where Jim and I ran laps around the parking lot of a Holiday Inn for his daily workout.

  2. Advanced photomask reconstruction with the Seiko SIR 3000

    NASA Astrophysics Data System (ADS)

    Ruatta, Stephen A.; Smith, Eryn L.; Yasaka, Anto

    1997-02-01

    OPC and other complicated geometric structures are increasingly common on production masks. These features may be small, have highly irregular shapes and may not be repeated in a nearby region. These features make it difficult for a repair operator to know where the defect stops and the desired pattern begins. We are increasingly called upon to write masks with these complicated patterns, high densities and long write times. In order to meet our customers demand for shorter turnaround times and high throughput, it makes sense to implement new, more sophisticated repair techniques. We have recently acquired a new, state of the art Seiko SIR3000 FIB (focused ion beam) mask repair system. This system is a sophisticated secondary ion mass spectrometer (SIMS) that uses a focused primary beam of gallium ions to both image and repair mask defects. Both opaque and clear defects can be reconstructed by the gallium beam. The SIR3000 system uses a proprietary material (alpha-gas) to reduce glass damage caused by the sputtering process. We have performed some preliminary measurements to determine the extent of the glass damage and performed some introductory work into methods of reducing the damage further. We present some of the data we use to monitor its performance, a number of examples illustrating its utility and our expectations for the tool in the near future.

  3. Multiple incidence angle SIR-B experiment over Argentina

    NASA Technical Reports Server (NTRS)

    Cimino, Jobea; Casey, Daren; Wall, Stephen; Brandani, Aldo; Domik, Gitta; Leberl, Franz

    1986-01-01

    The Shuttle Imaging Radar (SIR-B), the second synthetic aperture radar (SAR) to fly aboard a shuttle, was launched on October 5, 1984. One of the primary goals of the SIR-B experiment was to use multiple incidence angle radar images to distinguish different terrain types through the use of their characteristic backscatter curves. This goal was accomplished in several locations including the Chubut Province of southern Argentina. Four descending image acquisitions were collected providing a multiple incidence angle image set. The data were first used to assess stereo-radargrammetric techniques. A digital elevation model was produced using the optimum pair of multiple incidence angle images. This model was then used to determine the local incidence angle of each picture element to generate curves of relative brightness vs. incidence angle. Secondary image products were also generated using the multi-angle data. The results of this work indicate that: (1) various forest species and various structures of a single species may be discriminated using multiple incidence angle radar imagery, and (2) it is essential to consider the variation in backscatter due to a variable incidence angle when analyzing and comparing data collected at varying frequencies and polarizations.

  4. PEOPLE IN PHYSICS: Interview with Sir Arnold Wolfendale FRS

    NASA Astrophysics Data System (ADS)

    Wiltsher, Conducted by Nicholas

    1997-11-01

    Sir Arnold Wolfendale was born on 25 June 1927, the son of Arnold and Doris Wolfendale. His BSc in Physics with First Class honours from the University of Manchester in 1948 was followed by a PhD in 1953 and a DSc in 1970. He was elected a Fellow of the Royal Society in 1977, and of the Royal Astronomical Society in 1973. In 1951 he married Audrey Darby, and they have twin sons. Sir Arnold's career has included lecturing posts at the Universities of Manchester, Durham, Ceylon and Hong Kong, and he was head of department at Durham. He retired from teaching in 1992 and was knighted in 1995. From 1991 to 1995 he was Astronomer Royal. Since 1996 he has been Professor of Experimental Physics with the Royal Institution of Great Britain. He has given lectures in many countries and in many places, and has had several books published on the subject of cosmic rays and astrophysics. He lives in Durham.

  5. Sir William Osler's speech at Troy: a Trojan horse?

    PubMed

    Moran, Michael E

    2012-01-01

    Troy, New York, is a city of 55,000 people in upstate New York located along the Hudson River. A city of surprisingly rich cultural heritage, it was the home of New York state's first hospital outside New York City. The 50th anniversary celebration of Troy's hospital brought William Osler to the city as the keynote speaker. This speech, delivered on November 28, 1900, is one of Sir William's less well known addresses. Osler began his comments with Sir Thomas More's Utopia and talked at length about the hospital, its obligations, the influences it has upon the community, and the role of physicians and surgeons. He broached one of his old saws, the salary of attending physicians and their needed role in hospital management. His words were published in the diamond jubilee's records, but the hospital did not outlive its prominent guest professor, and it closed its doors in 1914. Just like the great historical city of Troy, New York's own Troy was on the brink of decline, and its hospital would be the first fatality. Therefore, it is almost prescient that the words of Osler, taken into historical context juxtaposed against the socioeconomic forces at work, are akin to the Greek's offering of a wooden edifice to end the Trojan War. PMID:22275788

  6. 19. John and James Dobson Carpet Mills, West parcel, topographical ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. John and James Dobson Carpet Mills, West parcel, topographical plan, 1986. Barton and Martin, Engineers. 'Topographical Plan for Dobson Mills.' Prepared for Rouse Urban Housing, Inc., Philadelphia, Pennsylvania, 1986. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  7. 75 FR 13323 - James A. Fitzpatrick Nuclear Power Plant; Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION James A. Fitzpatrick Nuclear Power Plant; Exemption 1.0 Background Entergy Nuclear Operations, Inc. (the licensee) is the holder of Facility Operating License No. DPR-59, which authorizes operation of the James A. FitzPatrick Nuclear Power Plant...

  8. 3. Photocopy of Plate #13, 'Interior of St. James, Thirtyeighth ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of Plate #13, 'Interior of St. James, Thirty-eighth and Chestnut Sts.', in Architectural Album of Edwin F. Durang and Son, 1200. Chestnut St., Philadelphia (a privately bound volume). Exact date not noted. - St. James Roman Catholic Church, 3728 Chestnut Street, Philadelphia, Philadelphia County, PA

  9. 2. Photocopy of Plate #12, 'St. James Church, Thirtyeighth and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of Plate #12, 'St. James Church, Thirty-eighth and Chestnut Sts.', in Architectural Album of Edwin F. Durang and Son, 1200 Chestnut St., Philadelphia (a privately bound volume). Exact date not noted. - St. James Roman Catholic Church, 3728 Chestnut Street, Philadelphia, Philadelphia County, PA

  10. 1. VIEW OF JAMES H. LANE BARN (HEREAFTER LANE BARN) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW OF JAMES H. LANE BARN (HEREAFTER LANE BARN) FROM L.D.S. CHURCH GROUNDS ON IDAHO HIGHWAY 26, APPROXIMATELY 1/4 MILE EAST OF THE MAIN INTERSECTION OF RICHFIELD, IDAHO. CAMERA IS POINTING SOUTH. - James H. Lane Ranch, Barn, One Mile South of Richfield on Highway 26, Richfield, Lincoln County, ID

  11. Metacognition and Self-Regulation in James, Piaget, and Vygotsky

    ERIC Educational Resources Information Center

    Fox, Emily; Riconscente, Michelle

    2008-01-01

    This article investigates the intertwined constructs of metacognition and self-regulation as they emerge in the works and theories of James, Piaget, and Vygotsky. To coordinate this exploration, we use an interpretive framework based on the relation of subject and object. In this framework, James's perspective on metacognition and self-regulation…

  12. 18. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. John and James Dobson Carpet Mill, East and West parcels, site plan-lower left, and surrounding environs, 1925. Bromley, George Washington and Bromley, Walter Scott. Atlas of the City of Philadelphia (North Philadelphia), Philadelphia, Pennsylvania: George W. and Walter S. Bromley, 1925, p. 106. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  13. 1. Historic American Buildings Survey James F. and Jean B. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey James F. and Jean B. O'Gorman, Photographers October 1963 EXTERIOR FROM THE SOUTHEAST Gift of James F. and Jean B. O'Gorman - Stephen Higginson Jr. House, 7 Kirkland Street, Cambridge, Middlesex County, MA

  14. 2. Historic American Buildings Survey James F. and Jean B. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey James F. and Jean B. O'Gorman, Photographers October 1963 EXTERIOR FROM THE SOUTHWEST Gift of James F. and Jean B. O'Gorman - Stephen Higginson Jr. House, 7 Kirkland Street, Cambridge, Middlesex County, MA

  15. 5. Historic American Buildings Survey James F. and Jean B. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey James F. and Jean B. O'Gorman, Photographers October 1963 MID-19th-CENTURY MANTELPIECE IN EAST CHAMBER, SECOND FLOOR Gift of James F. and Jean B. O'Gorman - Stephen Higginson Jr. House, 7 Kirkland Street, Cambridge, Middlesex County, MA

  16. 4. Historic American Buildings Survey James F. and Jean B. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey James F. and Jean B. O'Gorman, Photographers October 1963 LATE 19th-CENTURY MANTELPIECE IN FIRST FLOOR ROOM Gift of James F. and Jean B. O'Gorman - Stephen Higginson Jr. House, 7 Kirkland Street, Cambridge, Middlesex County, MA

  17. 3. Historic American Buildings Survey James F. and Jean B. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey James F. and Jean B. O'Gorman, Photographers October 1963 ORIGINAL MANTELPIECE AND WINDOW SHUTTERS, FIRST FLOOR Gift of James F. and Jean B. O'Gorman - Stephen Higginson Jr. House, 7 Kirkland Street, Cambridge, Middlesex County, MA

  18. The National Writing Project: A Best Idea from James Gray.

    ERIC Educational Resources Information Center

    Jago, Carol

    2003-01-01

    Discusses how James Gray, founder of the Bay Area Writing Project and later the National Writing Project, began with a simple idea--successful teachers are the best teachers of teachers. Describes how James Gray laid a foundation for what has become a national network with 175 sites across the nation, providing a professional home for thousands of…

  19. 10. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. John and James Dobson Carpet Mill, East and West parcels, site plan-lower right, and surrounding environs, 1875. Hopkins, Griffith Morgan. City Atlas of Philadelphia by Wards, 7 vols., Philadelphia, Pennsylvania: G. M. Hopkins and Co., 1875, pp. 46-47. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  20. 9. John and James Dobson Carpet Mill, portion of West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. John and James Dobson Carpet Mill, portion of West parcel, site plan-left, elevation-upper right, and survey-lower right, 1873. Hexamer, Ernest and Son. Hexamer General Surveys 1867-1895, Philadelphia, Pennsylvania: E. Hexamer and Son, 1873, pp. 670-671. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  1. 13. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. John and James Dobson Carpet Mill, East and West parcels, site plan-upper left, elevation-upper right, and survey-below, 1885. Hexamer, Ernest and Son. Hexamer General Surveys, 1867-1895, Philadelphia, Pennsylvania: E. Hexamer and Son, 1885, pp. 1890-1891. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  2. 11. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. John and James Dobson Carpet Mill, East and West parcels, site plan-upper left, elevation-lower left, and survey-right, 1877. Hexamer, Ernest and Son. Hexamer General Surveys, 1867-1895, Philadelphia, Pennsylvania: E. Hexamer and Son, 1877, pp. 1095-1096. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  3. 16. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. John and James Dobson Carpet Mill, East and West parcels, site plan-right, and western environs, 1908. Smith, Elvino Victor. Atlas of the 38th and Part of the 37th Ward of the City of Philadelphia, Philadelphia, Pennsylvania: Elvino V. Smith, 1908, Plate 24. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  4. 17. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. John and James Dobson Carpet Mill, East and West Parcels, site plan, revised through 1914. Hexamer, Ernest and Son. Insurance Maps of the City of Philadelphia, Vol. 21., Philadelphia, Pennsylvania: E. Hexamer and Son, 1893. Revisions, 1914, p. 446. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  5. 14. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. John and James Dobson Carpet Mill, East and West parcels, site plan, revised through 1895. Hexamer, Ernest and Son. Insurance Maps of the City of Philadelphia, Vol. 21., Philadelphia, Pennsylvania: E. Hexamer and Son, 1893. Revisions, 1895, p. 446. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  6. James Astor in conversation with Warren Colman.

    PubMed

    Astor, James

    2013-11-01

    In this interview with Warren Colman, James Astor speaks about his development as a Jungian analyst from his own experience of personal analysis in the 1960s to his recent retirement from clinical practice. The discussion covers his long association with Michael Fordham, the child analytic training at the SAP, the infant observation seminars with Fordham and Gianna Henry through which Fordham was able to make new discoveries about infant development, his experience of supervision with Donald Meltzer and the development of his own thinking through a series of papers on the analytic process, supervision and the relation between language and truth. The interview concludes with reflections about the legacy of Michael Fordham and the future of analytic work. PMID:24237210

  7. Overview of the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Clampin, Mark

    2011-01-01

    The James Webb Space Telescope (JWST) is a large aperture (6.5 meter), cryogenic space telescope with a suite of near and mid-infrared instruments covering the wavelength range of 0.6 microns to 28 microns. JWST's primary science goals are to detect and characterize the first galaxies, and study the assembly of galaxies, star formation, and the formation of evolution of planetary systems. JWST is a segmented mirror telescope operating at approx.40K, a temperature achieved by passive cooling of the observatory, via a large, 5-layer membrane-based sunshield. We will review the scientific capabilities of JWST in the context of their synergy with survey facilities, and with the next generation of ground-based Extremely Large Telescopes. We will also present an overview of the observatory design, and report on recent progress in the construction of the observatory and its science instruments.

  8. James Webb Space Telescope Station-keeping

    NASA Technical Reports Server (NTRS)

    Beckman, Mark

    2003-01-01

    The James Webb Space Telescope (JWST) is planned to be launched in 2011 to the Sun- Earth L2 libration point. The resultant delta-Vs (dV) from momentum unloads will perturb the orbit and necessitate frequent station-keeping maneuvers. The station-keeping dV budget is highly sensitive to the direction of the resultant dV vector. A simple spacecraft reorientation prior to each momentum unload will allow some control over the direction of the resultant dV vector. For each inertial momentum vector direction, an optimum spacecraft attitude is determined which gives a resultant dV vector that requires the least amount of station-keeping dV. Using this procedure, the station-keeping dV budget for JWST can be reduced by 60%.

  9. Remembering James Alan Bassham (1922-2012).

    PubMed

    Govindjee; Bassham, Helen; Bassham, Susan

    2016-04-01

    James Alan Bassham, known to many as Al, was born on November 26, 1922, in Sacramento, California (CA), USA. He died on November 19, 2012, in El Cerrito, CA. To celebrate his life at his 3rd death anniversary, we present here a brief biography, comments on his discoveries, but most importantly, remembrances from family and friends; we remember this wonderful and modest person who had played a major pivotal role in the discoveries that led to what he would like to call the P(hotosynthetic) C(arbon) R(eduction) cycle, known to many as the Calvin Cycle, the Calvin-Benson Cycle, or the Calvin-Benson-Bassham Cycle. Based on a personal request by Bassham himself to one of us (Govindjee), we refrain from including his name in the cycle-in recognition of his many students and associates he would have liked to honor. PMID:26582593

  10. James Webb Space Telescope Project (JWST) Overview

    NASA Technical Reports Server (NTRS)

    Dutta, Mitra

    2008-01-01

    This presentation provides an overview of the James Webb Space Telescope (JWST) Project. The JWST is an infrared telescope designed to collect data in the cosmic dark zone. Specifically, the mission of the JWST is to study the origin and evolution of galaxies, stars and planetary systems. It is a deployable telescope with a 6.5 m diameter, segmented, adjustable primary mirror. outfitted with cryogenic temperature telescope and instruments for infrared performance. The JWST is several times more sensitive than previous telescope and other photographic and electronic detection methods. It hosts a near infrared camera, near infrared spectrometer, mid-infrared instrument and a fine guidance sensor. The JWST mission objection and architecture, integrated science payload, instrument overview, and operational orbit are described.

  11. Heat Stress-Induced Cup9-Dependent Transcriptional Regulation of SIR2

    PubMed Central

    Laskar, Shyamasree; K, Sheeba; Bhattacharyya, Mrinal K.; Nair, Achuthsankar S.; Dhar, Pawan

    2014-01-01

    The epigenetic writer Sir2 maintains the heterochromatin state of chromosome in three chromosomal regions, namely, the silent mating type loci, telomeres, and the ribosomal DNA (rDNA). In this study, we demonstrated the mechanism by which Sir2 is regulated under heat stress. Our study reveals that a transient heat shock causes a drastic reduction in the SIR2 transcript which results in sustained failure to initiate silencing for as long as 90 generations. Hsp82 overexpression, which is the usual outcome of heat shock treatment, leads to a similar downregulation of SIR2 transcription. Using a series of genetic experiments, we have established that heat shock or Hsp82 overexpression causes upregulation of CUP9 that, in turn, represses SIR2 transcription by binding to its upstream activator sequence. We have mapped the cis regulatory element of SIR2. Our study shows that the deletion of cup9 causes reversal of the Hsp82 overexpression phenotype and upregulation of SIR2 expression in heat-induced Hsp82-overexpressing cells. On the other hand, we found that Cup9 overexpression represses SIR2 transcription and leads to a failure in the establishment of heterochromatin. The results of our study highlight the mechanism by which environmental factors amend the epigenetic configuration of chromatin. PMID:25384977

  12. William James, Gustav Fechner, and Early Psychophysics

    PubMed Central

    Hawkins, Stephanie L.

    2011-01-01

    American psychologist and philosopher William James devoted the entirety of his career to exploring the nature of volition, as expressed by such phenomena as will, attention, and belief. As part of that endeavor, James’s unorthodox scientific pursuits, from his experiments with nitrous oxide and hallucinogenic drugs to his investigation of spiritualist mediums, represent his attempt to address the “hard problems” of consciousness for which his training in brain physiology and experimental psychology could not entirely account. As a student, James’s reading in chemistry and physics had sparked his interest in the concepts of energy and force, terms that he later deployed in his writing about consciousness and in his arguments against philosophical monism and scientific materialism, as he developed his “radically empiricist” ideas privileging discontinuity and plurality. Despite James’s long campaign against scientific materialism, he was, however, convinced of the existence of a naturalistic explanation for the more “wayward and fitful” aspects of mind, including transcendent experiences associated with hysteria, genius, and religious ecstasy. In this paper, I examine aspects of James’s thought that are still important for contemporary debates in psychology and neuroscience: his “transmission theory” of consciousness, his ideas on the “knowing of things together,” and, finally, the related concept of “the compounding of consciousness,” which postulates the theoretical possibility for individual entities within a conscious system of thought to “know” the thoughts of others within the system. Taken together, these ideas suggest that James, in spite of, or perhaps because of, his forays into metaphysics, was working toward a naturalistic understanding of consciousness, what I will term a “distributive model,” based on his understanding of consciousness as an “awareness” that interacts dynamically within, and in relation to

  13. Evaluation of SIR-B imagery for geologic and geomorphic mapping, hydrology, and oceanography in Australia

    NASA Technical Reports Server (NTRS)

    Honey, F. R.; Simpson, C. J.; Huntington, J.; Horwitz, R.; Byrne, G.; Nilsson, C.

    1984-01-01

    The objectives of a study to evaluate the potential of Shuttle Imaging Radar-B (SIR-B) imagery for various applications are outlined. Specific goals include: the development of techniques for registration multiple acquisition, varied illumination, and incidence-angle SIR-B imagery, and a model for estimation of the relative contributions to the backscattered radiation of topography, surface roughness, and dielectric and conductivity components; (2) the evaluation of SIR-B imagery for delineation of agricultural lands affected by secondary salinity in the southwest and southeast agricultural regions of Australia; (3) the development of techniques for application of SIR-B imagery for geologic, geomorphologic and soils mapping and mineral exploration; and (4) the evaluation of the use of SIR-B imagery in determining ocean currents, current shear patterns, internal waves and bottom features for specific locations off the Australian coast.

  14. [Basic concept and definition of SIRS and sepsis--present consideration and future perspectives].

    PubMed

    Hirasawa, Hiroyuki; Oda, Shigeto; Matsuda, Kenichi; Watanabe, Eizo

    2004-12-01

    SIRS (systemic inflammatory response syndrome) is thought to be caused by hypercytokinemia. On the other hand, interleukin-6 (IL-6) is reported to be one of most easily measurable cytokines and we found that IL-6 blood levels on SIRS patients are above 1,500 pg/ml which is compatible to the previously reported values. Since only 6% of SIRS patients developed MOF according to our own data, we need not overestimate SIRS as a grave clinical signs. On the other hand, it is reported that cytokine-related genetic polymorphism may affect the cytokine production following insult, or may affect the development of SIRS following insult. Therefore, we must also consider genetic aspect of cytokine biology in future study. PMID:15597782

  15. Development of a calibration workstation for SIR-C

    NASA Technical Reports Server (NTRS)

    Madsen, S. N.; Dubois, P.; Freeman, A.; Norikane, L.; Shaffer, S.; Shimada, J.

    1991-01-01

    The paper describes the status of a comprehensive synthetic aperture radar (SAR) software package developed specifically to aid the calibration of a multifrequency and multipolarization radar like the Shuttle Imaging Radar, SIR-C. The primary data types processed are engineering telemetry, point targets (corner reflectors and polarimetric active radar calibrators), distributed targets (clutter), tone-generators, and ground receivers. The parameters derived to aid the calibration of the production processor include measurements of relative radiometric channel to channel imbalance, absolute calibration constants, antenna pattern corrections, noise levels, polarimetric cross-talk, and geometric offsets. The software reports standard performance measurements such as resolution, peak and integrated sidelobes, radiometric response accuracy, and geometrical distortions such as scale errors, position bias and standard deviation, and image skew. Furthermore, the inclusion of software to allow updates of the shuttle-state vector (position and velocity) is considered.

  16. Development of a calibration workstation for SIR-C

    NASA Astrophysics Data System (ADS)

    Madsen, S. N.; Dubois, P.; Freeman, A.; Norikane, L.; Shaffer, S.; Shimada, J.

    The paper describes the status of a comprehensive synthetic aperture radar (SAR) software package developed specifically to aid the calibration of a multifrequency and multipolarization radar like the Shuttle Imaging Radar, SIR-C. The primary data types processed are engineering telemetry, point targets (corner reflectors and polarimetric active radar calibrators), distributed targets (clutter), tone-generators, and ground receivers. The parameters derived to aid the calibration of the production processor include measurements of relative radiometric channel to channel imbalance, absolute calibration constants, antenna pattern corrections, noise levels, polarimetric cross-talk, and geometric offsets. The software reports standard performance measurements such as resolution, peak and integrated sidelobes, radiometric response accuracy, and geometrical distortions such as scale errors, position bias and standard deviation, and image skew. Furthermore, the inclusion of software to allow updates of the shuttle-state vector (position and velocity) is considered.

  17. Sir Robert Ball: Victorian Astronomer and Lecturer par excellence

    NASA Astrophysics Data System (ADS)

    Jones, R. I. G.

    2005-12-01

    Between 1875 and 1910 Sir Robert Stawell Ball gave an estimated 2,500 lectures in towns and cities all over the British Isles and abroad. This paper traces his lecturing career from its beginnings in Ireland to the triumphs of the Royal Institution, and on lecture tours in the United States of America. After a period in mathematics and mechanics, he became a populariser of science, especially astronomy, and found fame and fortune among the working classes and the aristocracy. What motivated him to tireless travels is uncertain, but it might have been that it was rewarding, financially and to his reputation. Whatever his motives, contemporary accounts are clear that BallÕs lectures were extremely popular and well-received.

  18. Sir Francis Galton and the birth of eugenics.

    PubMed

    Gillham, N W

    2001-01-01

    The eugenics movement was initiated by Sir Francis Galton, a Victorian scientist. Galton's career can be divided into two parts. During the first, Galton was engaged in African exploration, travel writing, geography, and meteorology. The second part began after he read the Origin of Species by his cousin Charles Darwin. The book convinced Galton that humanity could be improved through selective breeding. During this part of his career he was interested in the factors that determine what he called human "talent and character" and its hereditary basis. Consequently, he delved into anthropometrics and psychology and played a major role in the development of fingerprinting. He also founded the field of biometrics, inventing such familiar statistical procedures as correlation and regression analysis. He constructed his own theory of inheritance in which nature and not nurture played the leading role. He actively began to promote eugenics and soon gained important converts. PMID:11700278

  19. SIRS Dynamics on Random Networks: Simulations and Analytical Models

    NASA Astrophysics Data System (ADS)

    Rozhnova, Ganna; Nunes, Ana

    The standard pair approximation equations (PA) for the Susceptible-Infective-Recovered-Susceptible (SIRS) model of infection spread on a network of homogeneous degree k predict a thin phase of sustained oscillations for parameter values that correspond to diseases that confer long lasting immunity. Here we present a study of the dependence of this oscillatory phase on the parameter k and of its relevance to understand the behaviour of simulations on networks. For k = 4, we compare the phase diagram of the PA model with the results of simulations on regular random graphs (RRG) of the same degree. We show that for parameter values in the oscillatory phase, and even for large system sizes, the simulations either die out or exhibit damped oscillations, depending on the initial conditions. This failure of the standard PA model to capture the qualitative behaviour of the simulations on large RRGs is currently being investigated.

  20. Sir Robert Jones: orthopaedic surgeon and war hero.

    PubMed

    Di Matteo, Berardo; Tarabella, Vittorio; Filardo, Giuseppe; Tomba, Patrizia; Viganò, Anna; Kon, Elizaveta; Marcacci, Maurilio

    2015-05-01

    The First World War was a very harsh conflict and statistics recorded a great number of victims, both soldiers and civilians. One hundred years later, the whole world is commemorating the Great War by celebrating people and events that contributed to shaping the XX century. Beyond remembering political figures, war heroes or even famous battles, it is also important to underline the contribution of those who devoted their efforts to improve the living conditions during war campaigns. This is the case of Sir Robert Jones, one of the fathers of XX century orthopaedics, who contributed to re-organize the military medical assistance during war times and whose teachings, coming directly from his "on the field" experience, inspired an entire generation of European surgeons. PMID:25435061

  1. Fatal SIR diseases and rational exemption to vaccination.

    PubMed

    d'Onofrio, Alberto; Manfredi, Piero; Salinelli, Ernesto

    2008-12-01

    A challenge to disease control in modern societies is the spread of rational exemption to vaccination as a consequence of the rational comparison between the steadily declining risk of infection and the risk of side effects from the vaccine. Here, we consider rational exemption in an susceptible-infectious-removed (SIR) model with information-dependent vaccination where individuals use information on the disease's mortality as their information set. Using suitable assumptions on the dynamics of the population, we show the dynamic implications of the interaction between rational exemption, current and delayed information and the risk of death by the disease. In particular, we illustrate the onset of the long cycles caused by rational exemption when vaccination decisions are based on delayed informations. PMID:18840601

  2. Precipitation measurement using SIR-C: A feasibility study

    NASA Technical Reports Server (NTRS)

    Ahamad, Atiq; Moore, Richard K.

    1993-01-01

    A precipitation detection and measurement experiment is planned for the SIR-C/X-SAR mission. This study was conducted to determine under what conditions an off-nadir experiment is feasible. The signal-to-clutter ratio, the signal-to-noise ratio, and the minimum detectable rain rate were investigated. Available models, used in previous studies, were used for the surface clutter and the rain echo. The study also considers the attenuation of the returns at X band. It was concluded that an off-nadir rain-measurement experiment is feasible only for rain rates greater than 10 mm/hr for look angles greater than 60 deg. For the range of look angles 5 less than theta(sub 1) less than 50, the rain rate required is very high for adequate signal-to-clutter ratio, and hence the feasibility of the experiment.

  3. Sir William Herschel's notebooks - Abstracts of solar observations

    NASA Technical Reports Server (NTRS)

    Hoyt, Douglas V.; Schatten, Kenneth H.

    1992-01-01

    An introduction to the background of Sir William Herschel's notebooks and the historical context within which his observations were made are provided. The observations have relevance in reconstructing solar behavior, as discussed in a separate analysis paper by Hoyt and Schatten (1992), and in understanding active features on the sun such as faculae. The text of Herschel's notebooks with modern terms used throughout forms the body of this paper. The complete text has not previously been published and is not easily accessible to scholars. Herschel used different words for solar features than are used today, and thus, for clarity, his terminology is changed on two occasions. A glossary explains the terminology changed. In the text of the notebooks, several contemporaries are mentioned; a brief description of Herschel's colleagues is provided.

  4. Sir Harry Sinderson Pasha and Iraq's first medical school.

    PubMed

    Al-Fattal, Sa'ad

    2013-08-01

    During the early twentieth century, the medical status of Mesopotamia, later Iraq, was very bad due to the lack of sanitation and recurrent epidemics and it was rife with endemic diseases including bilharziasis, tuberculosis and malaria. Medical care was poor, with few hospitals and doctors. The condition improved slowly with the return of a few Iraqi doctors who trained outside Iraq, in Turkey, Syria and Lebanon, and with the arrival of British Medical personnel, during and after the First World War, principally Sir Harry Sinderson who was one of the most influential figures in recent Iraqi medical and political history. He had the distinctive role of being one of the founders and the Dean of the first Iraqi medical college. During his service until his retirement in 1946 he achieved, with tireless effort, exceptionally high standards and brought fame and prestige to the new medical college in record time. He attained his goal of training at least 500 local doctors. PMID:24585764

  5. The SIRS Model of Epidemic Spreading in Virtual Society

    NASA Astrophysics Data System (ADS)

    Grabowski, A.; Kosiński, R.

    2008-09-01

    Dedicated to Professor Dietrich Stauffer on the occasion of his 65th birthday The phenomenon of epidemic spreading in a real social network is described and investigated numerically. On the basis of data concerning amount of time devoted daily to social interactions, the influence of human activity on spreading process is investigated in the frame of SIRS model. It was found that the activity of an individual is positively correlated with its connectivity and the relation has power law form. The influence of control measures on the spreading process is investigated as a function of initial conditions. The cost-effectiveness of mass immunizations campaigns and target vaccinations is compared. It was found that the form of activity distribution has significant influence on the spreading phenomena in the network.

  6. SIR dynamics in random networks with heterogeneous connectivity.

    PubMed

    Volz, Erik

    2008-03-01

    Random networks with specified degree distributions have been proposed as realistic models of population structure, yet the problem of dynamically modeling SIR-type epidemics in random networks remains complex. I resolve this dilemma by showing how the SIR dynamics can be modeled with a system of three nonlinear ODE's. The method makes use of the probability generating function (PGF) formalism for representing the degree distribution of a random network and makes use of network-centric quantities such as the number of edges in a well-defined category rather than node-centric quantities such as the number of infecteds or susceptibles. The PGF provides a simple means of translating between network and node-centric variables and determining the epidemic incidence at any time. The theory also provides a simple means of tracking the evolution of the degree distribution among susceptibles or infecteds. The equations are used to demonstrate the dramatic effects that the degree distribution plays on the final size of an epidemic as well as the speed with which it spreads through the population. Power law degree distributions are observed to generate an almost immediate expansion phase yet have a smaller final size compared to homogeneous degree distributions such as the Poisson. The equations are compared to stochastic simulations, which show good agreement with the theory. Finally, the dynamic equations provide an alternative way of determining the epidemic threshold where large-scale epidemics are expected to occur, and below which epidemic behavior is limited to finite-sized outbreaks. PMID:17668212

  7. Science with the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2012-01-01

    The science objectives of the James Webb Space Telescope fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and black holes within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and to investigate the potential for life in those systems. These four science themes were used to establish the design requirements for the observatory and instrumentation. Since Webb's capabilities are unique, those science themes will remain relevant through launch and operations and goals contained within these themes will continue to guide the design and implementation choices for the mission. More recently, it has also become clear that Webb will make major contributions to other areas of research, including dark energy, dark matter, active galactic nuclei, stellar populations, exoplanet characterization and Solar System objects. In this paper, we review the original four science themes and discuss how the scientific output of Webb will extend to these new areas of research. The James Webb Space Telescope was designed to meet science objectives in four themes: The End of the Dark Ages: First Light and Reionization, The Assembly of Galaxies, The Birth of Stars and Protoplanetary Systems, and Planetary Systems and the Origins of Life. More recently, it has become clear that Webb will also make major contributions to studies of dark energy, dark matter

  8. SirT1 in muscle physiology and disease: lessons from mouse models

    PubMed Central

    Vinciguerra, Manlio; Fulco, Marcella; Ladurner, Andreas; Sartorelli, Vittorio; Rosenthal, Nadia

    2010-01-01

    Sirtuin 1 (SirT1) is the largest of the seven members of the sirtuin family of class III nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases, whose activation is beneficial for metabolic, neurodegenerative, inflammatory and neoplastic diseases, and augments life span in model organisms (Finkel et al., 2009; Lavu et al., 2008). In vitro studies show that SirT1 protects genome integrity and is involved in circadian physiological rhythms (Asher et al., 2008; Nakahata et al., 2008; Oberdoerffer et al., 2008). In the last few years, a fundamental role for SirT1 in the metabolism and differentiation of skeletal muscle cells has been uncovered (Fulco et al., 2003), and the use of specific transgenic or knockout SirT1 mouse models implicates it in the protection of heart muscle from oxidative and hypertrophic stresses (Alcendor et al., 2007). In this Perspective, we review the recent exciting findings that have established a key role for the ’longevity’ protein SirT1 in skeletal and heart muscle physiology and disease. Furthermore, given the multiple biological functions of SirT1, we discuss the unique opportunities that SirT1 mouse models can offer to improve our integrated understanding of the metabolism, as well as the regeneration and aging-associated changes in the circadian function, of skeletal and heart muscle. PMID:20354108

  9. Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes

    PubMed Central

    Sanders, Brandi D.; Zhao, Kehao; Slama, James T.; Marmorstein, Ronen

    2009-01-01

    SUMMARY The Sir2 family of proteins are broadly conserved NAD+-dependant deacetylases that are implicated in diverse biological processes including DNA regulation, metabolism and longevity. Sir2 proteins are regulated in part by the cellular concentrations of a noncompetitive inhibitor, nicotinamide, that reacts with a Sir2 reaction intermediate via a base exchange reaction to reform NAD+ at the expense of deacetylation. To gain a mechanistic understanding of nicotinamide inhibition in Sir2 enzymes, we captured the structure of nicotinamide bound to a Sir2 homologue, yeast Hst2, in complex with its acetyl-lysine 16 histone H4 substrate and a reaction intermediate analog, ADP-HPD. Together with related biochemical studies and structures, we identify a nicotinamide inhibition and base exchange site that is distinct from the so-called “C pocket” binding site for the nicotinamide group of NAD+. These results provide insights into the Sir2 mechanism of nicotinamide inhibition and have important implications for the development of Sir2-specific effectors. PMID:17289592

  10. Structural Integrity Recording System (SIR) for U.S. Army AH-1G Helicopters

    NASA Astrophysics Data System (ADS)

    Farrell, T. G.; Johnson, R. B.; Tyler, M. C.

    1981-03-01

    A Structural Integrity Recording System (SIRS) was designed and developed to track the fatigue damage accumulation on 10 critical helicopter components for the subsequent timely replacement of such components for safer and more economical helicopter operation. SIRS comprises three discrete but interrelated subsystems: an airborne microprocessor-based recorder, a portable flight-line data retrieval unit, and a software system. The validation of SIRS, initially configured for the AH-1G helicopter, consisted of two phases. Phase I (Development Test and Evaluation - DT E) covered the design, fabrication, laboratory qualification testing, reliability analysis, and flight-testing of the prototype SIRS recorder. Phase II (Initial Operational Test and Evaluation - IOT E) covered the evaluation of the entire system operation and the resultant data acquired during a 3-month recording period with five AH-1G's, each equipped with a SIRS recorder. As the documentation of both DT E and IOT E, this report describes the characteristics and functions of the entire system and details the successful performance of the SIRS recorder in the laboratory qualification testing and the flight environment. The SIRS recorder performed as designed, operated reliably, and yielded valid data.

  11. Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes

    SciTech Connect

    Sanders, B.; Zhao, K; Slama, J; Marmorstein, R

    2007-01-01

    The Sir2 family of proteins consists of broadly conserved NAD+-dependent deacetylases that are implicated in diverse biological processes, including DNA regulation, metabolism, and longevity. Sir2 proteins are regulated in part by the cellular concentrations of a noncompetitive inhibitor, nicotinamide, that reacts with a Sir2 reaction intermediate via a base-exchange reaction to reform NAD+ at the expense of deacetylation. To gain a mechanistic understanding of nicotinamide inhibition in Sir2 enzymes, we captured the structure of nicotinamide bound to a Sir2 homolog, yeast Hst2, in complex with its acetyl-lysine 16 histone H4 substrate and a reaction intermediate analog, ADP-HPD. Together with related biochemical studies and structures, we identify a nicotinamide inhibition and base-exchange site that is distinct from the so-called 'C pocket' binding site for the nicotinamide group of NAD+. These results provide insights into the Sir2 mechanism of nicotinamide inhibition and have important implications for the development of Sir2-specific effectors.

  12. Relationships between rDNA, Nop1 and Sir complex in biotechnologically relevant distillery yeasts.

    PubMed

    Adamczyk, Jagoda; Deregowska, Anna; Potocki, Leszek; Kuna, Ewelina; Kaplan, Jakub; Pabian, Sylwia; Kwiatkowska, Aleksandra; Lewinska, Anna; Wnuk, Maciej

    2016-09-01

    Distillery yeasts are poorly characterized physiological group among the Saccharomyces sensu stricto complex. As industrial yeasts are under constant environmental stress during fermentation processes and the nucleolus is a stress sensor, in the present study, nucleolus-related parameters were evaluated in 22 commercially available distillery yeast strains. Distillery yeasts were found to be a heterogeneous group with a variable content and length of rDNA and degree of nucleolus fragmentation. The levels of rDNA were negatively correlated with Nop1 (r = -0.59, p = 0.0038). Moreover, the protein levels of Sir transcriptional silencing complex and longevity regulators, namely Sir1, Sir2, Sir3 and Fob1, were studied and negative correlations between Sir2 and Nop1 (r = -0.45, p = 0.0332), and between Sir2 and Fob1 (r = -0.49, p = 0.0211) were revealed. In general, S. paradoxus group of distillery yeasts with higher rDNA pools and Sir2 level than S. bayanus group was found to be more tolerant to fermentation-associated stress stimuli, namely mild cold/heat stresses and KCl treatment. We postulate that rDNA state may be considered as a novel factor that may modulate a biotechnological process. PMID:27329282

  13. 2. Historic American Buildings Survey, James I. Campbell, Photographer February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, James I. Campbell, Photographer February 20, 1934 FRONT PORCH FROM EAST. - Nichols-Rice-Cherry House, Sam Houston Park (moved from San Jacinto Street), Houston, Harris County, TX

  14. 3. Historic American Buildings Survey, James I. Campbell, Photographer February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, James I. Campbell, Photographer February 20, 1934 SOUTH ELEVATION (FRONT). - Nichols-Rice-Cherry House, Sam Houston Park (moved from San Jacinto Street), Houston, Harris County, TX

  15. 5. Historic American Buildings Survey, James I. Campbell, Photographer February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, James I. Campbell, Photographer February 20, 1934 CLOSE-UP OF FRONT ENTRANCE. - Nichols-Rice-Cherry House, Sam Houston Park (moved from San Jacinto Street), Houston, Harris County, TX

  16. 4. Historic American Buildings Survey, James I. Campbell, Photographer February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, James I. Campbell, Photographer February 20, 1934 DETAIL OF FRONT ENTRANCE. - Nichols-Rice-Cherry House, Sam Houston Park (moved from San Jacinto Street), Houston, Harris County, TX

  17. 1. Historic American Buildings Survey, James I. Campbell, Photographer February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, James I. Campbell, Photographer February 20, 1934 VIEW FROM SOUTHEAST. - Nichols-Rice-Cherry House, Sam Houston Park (moved from San Jacinto Street), Houston, Harris County, TX

  18. 5. William Beardsley standing along canal section. Photographer James Dix ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. William Beardsley standing along canal section. Photographer James Dix Schuyler, 1903. Source: Schuyler report. - Waddell Dam, On Agua Fria River, 35 miles northwest of Phoenix, Phoenix, Maricopa County, AZ

  19. 5. Historic American Buildings Survey James Rainey, Photographer May 16, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey James Rainey, Photographer May 16, 1936 LIVING? (MUSIC) ROOM FIREPLACE (LOOKING NORTH? SOUTH) - Thaddeus Burr Homestead, 491 Old Post Road, Fairfield, Fairfield County, CT

  20. 4. Historic American Buildings Survey James C. Massey, Photographer 1964 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey James C. Massey, Photographer 1964 MAIN (SOUTH) ENTRANCE (4x5' b&w film copy neg. from 35mm slide) - Albert F. Madlener House, 4 West Burton Place, Chicago, Cook County, IL

  1. 5. Historic American Buildings Survey James C. Massey, Photographer 1964 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey James C. Massey, Photographer 1964 MAIN (SOUTH) ENTRANCE DETAIL (4x5' b&w film copy neg. from 35mm slide) - Albert F. Madlener House, 4 West Burton Place, Chicago, Cook County, IL

  2. Astronaut James Newman with latch hook for tether device

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Astronaut James H. Newman, mission specialist, shows off a latch hook for a tether device used during the STS-51 extravehicular activity (EVA) on September 16, 1993. Newman, on Discovery's middeck, appears surrounded by sleep restraints.

  3. Plan of the entresol (third floor) of James H. Windrim ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Plan of the entresol (third floor) of James H. Windrim and George Summers’s competition design for the New Masonic Temple, Philadelphia, 1867 - Masonic Temple, 1 North Broad Street, Philadelphia, Philadelphia County, PA

  4. Astronaut James van Hoften working with Syncom IV-3 satellite

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Astronaut James D. van Hoften gives a shove to the previously troubled Syncom IV-3 communications satellite. Dr. van Hoften stands on a foot restraint/extension to the remote manipulator system (RMS) arm.

  5. Fine Guidance System for the James Webb Space Telescope Delivered

    NASA Video Gallery

    Video has music in the background but no dialogue. The second of four main instruments to fly aboard NASA's James Webb Space Telescope (Webb) has been delivered to NASA. The Fine Guidance Sensor (F...

  6. NCGE Special Award Presented to James A. Michener.

    ERIC Educational Resources Information Center

    Boehm, Richard G.; de Souza, Anthony R.

    1985-01-01

    In 1984 the National Council for Geographic Education presented James Michener with a special award for his "Outstanding Contributions to Geographic Education through the American Novel." Michener's acceptance speech is presented. (RM)

  7. STS-69 Mission Specialist James H. Newman in white room

    NASA Technical Reports Server (NTRS)

    1995-01-01

    At Launch Pad 39A, STS-69 Mission Specialist James H. Newman chats with white room closeout crew members Rene Arriens (far left), Travis Thompson and Bob Saulnier (right) prior to entering the Space Shuttle Endeavour.

  8. 82. REGENTS' ROOM WEST WALL, WITH ORIGINAL CHAIRS BY JAMES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    82. REGENTS' ROOM WEST WALL, WITH ORIGINAL CHAIRS BY JAMES RENWICK, JR. MANTELPIECE AND MIRROR ARE NOT ORIGINAL TO THE ROOM. - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  9. 1. Historic American Buildings Survey James O. Milmoe, Photographer Winter ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey James O. Milmoe, Photographer Winter 1979 GENERAL VIEW OF PLYMOUTH PLACE WITH CAPTIOL IN BACKGROUND - Plymouth Place, 1560-1572 Broadway, Denver, Denver County, CO

  10. 5. Historic American Buildings Survey James Rainey, Photographer May 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey James Rainey, Photographer May 10, 1936 GRINDING PLATFORM, VIEW OF INTERIOR LOOKING WEST - Old Town Mill, Mill Brook, near Mill Street, New London, New London County, CT

  11. Young James Madison: His Character and Civic Values.

    ERIC Educational Resources Information Center

    Bennett, William J.

    1987-01-01

    Examines the life of James Madison, Founding Father and "theoretic statesman." Focuses specifically on Madison's education and character, his friendship with Thomas Jefferson, and his civic legacy: a selfless devotion to republican government and union. (JDH)

  12. Una mirada hacia el pasado -- El Telescopio Espacial James Webb

    NASA Video Gallery

    La NASA planea usar el nuevo Telescopio Espacial James Webb para mirar el pasado. Al observar la luz de las estrellas que se formaron al principio del universo, la NASA está a punto de arrojar nuev...

  13. Astronaut James D. van Hoften examines student experiment on Challenger

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut James D. van Hoften, 41-C mission specialist, holds an aluminum box full of honeybees. The experiment in earth orbit is duplicated with another colony of the bees on earth. This is an experiment submitted by student researchers.

  14. 6. Watchman Robert 'Jerry' Jones at Camp Dyer. Photographer James ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Watchman Robert 'Jerry' Jones at Camp Dyer. Photographer James Dix Schuyler, 1903. Source: Schuyler report. - Waddell Dam, On Agua Fria River, 35 miles northwest of Phoenix, Phoenix, Maricopa County, AZ

  15. Science with the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2006-01-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dustenshrouded protostars, to the genesis of planetary systems. Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these for science themes, JWST will be a large (6.5m) cold (50K) telescope with four instruments, capable of imaging and spectroscopy from 0.6 to 27 microns wavelength.

  16. James Paget Henry--a retrospective.

    PubMed

    Meehan, J P; Meehan, W P

    1997-01-01

    James Paget Henry really began his productive research career at the outset of the second world war. His studies of acceleration and the anoxia of high altitude were supported by the development of then new techniques of measuring and recording critical physiologic parameters such as vascular pressures, respiratory functions and haemoglobin saturation. His inquisitive mind made productive use of the instruments that had to be made by skilled instrument makers working in university shops. Much of this instrumentation has now found its way into the clinical arena where it is now the main armamentarium of cardiac diagnostic and respiratory function laboratories. His work in the space program preceeded that of the Russians but did not get recognition until Sputnik awakened the world to the possibilities of space flight. His development of the concept of a cardiovascular basis for fluid volume control and the supportive investigative work undertaken constitute a milestone in the annals of experimental physiology. The chimpanzees used in Project Mercury were found to be hypertensive which was related to the method of capture used by the commercial suppliers. This lead Jim to study the effect of early experience on resting blood pressure, an effort that soon developed into provocative studies of the biological basis of the stress response. PMID:9401600

  17. James Moores Ball: Ophthalmologist, medical historian, bibliophile.

    PubMed

    Feibel, Robert M

    2016-08-01

    James Moores Ball (1862-1929) was an ophthalmologist in St. Louis, Missouri, who excelled as a medical historian and collector of rare and historic books about the history of anatomy. During his lifetime, he was best known as the author of a comprehensive, authoritative, and popular textbook titled Modern Ophthalmology First published in 1904, there were five further editions. Ball was very interested in the history of anatomy and wrote two books on this subject, the first being a biography of Andreas Vesalius, one of the earliest in English, and the second a history of the resurrection men or grave robbers who sold corpses to professors of anatomy and surgery for teaching purposes. His legacy today is the 470 volumes of his personal library, which are now in the Archives and Rare Books department of the Becker Medical Library of the Washington University School of Medicine. These texts are one of their major collections, concentrating on the history of anatomy, beginning with a first edition of Vesalius's De Humani Corporis Fabrica and holding many important and beautiful landmark volumes of anatomical atlases. PMID:27316691

  18. Science with the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2010-01-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these for science themes, JWST will be a large (6.6m) cold (50K) telescope launched to the second Earth-Sun Lagrange point in 2014. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA.

  19. Science with the James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Gardner, J. P.; JWST Science Working Group

    2005-12-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these for science themes, JWST will be a large (6.5m) cold (50K) telescope launched to the second Earth-Sun Lagrange point early in the next decade. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA. JWST will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 27 microns.

  20. Microshutter Arrays for James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Li, Mary J.; Acuna, Nadine; Beamesderfer, Michael; Ewin, Audrey; Fettig, Rainer; Franz, Dave; Hess, Larry; Hu, Ron; Kelly, Dan; King, Todd

    2004-01-01

    Two-dimensional MEMS microshutter arrays are being developed at NASA Goddard Space Flight Center for use in the near-infrared region on the James Webb Space Telescope (JWST). The microshutter arrays are designed for the selective transmission of light with high efficiency and high contrast. The JWST environment requires cryogenic operation at 35K. Microshutter arrays are fabricated out of silicon-oxide-insulated (SOI) silicon wafers. Arrays are close-packed silicon nitride membranes with a pixel size of 100x200 p. Individual shutters are patterned with a torsion flexure permitting shutters to open 90 degrees with a minimized mechanical stress concentration. The mechanical shutter arrays are fabricated using MEMS technologies. The processing includes a multi- layer metal deposition and patterning of shutter electrodes and magnetic pads, reactive ion etching (NE) of the front side to form shutters out of the nitride membrane, an anisotropic back-etch for wafer thinning, followed by a deep RIE (DRIE) back-etch down to the nitride shutter membrane to form W e s and relieve shutters from the silicon substrate. An additional metal deposition and patterning is used to form back electrodes. Shutters are actuated using a magnetic force and latched using an electrostatic force. . . . KEYWORDS: microshutter, MEMS, RIE, DRIE, micro-optics, near inbred, space telescope

  1. STS-109 Crew Interviews: James H. Newman

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-109 Mission Specialist James H. Newman is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut, his career path, and his most memorable experiences. He gives details on the mission's goals and objectives, which focus on the refurbishing of the Hubble Space Telescope, and his role in the mission. He provides a brief background on the Hubble Space Telescope, and explains the plans for the rendezvous of the Columbia Orbiter with the Hubble Space Telescope. He provides details and timelines for each of the planned Extravehicular Activities (EVAs), which include replacing the solar arrays, changing the Power Control Unit, installing the Advanced Camera for Surveys (ACS), and installing a new Cryocooler for the Near Infrared Camera and Multi-Object Spectrometer (NICMOS). He gives further explanation of each of these pieces of equipment. He also describes the break-out plan in place for these spacewalks. The interview ends with Newman explaining the details of a late addition to the mission's tasks, which is to replace a reaction wheel on the Hubble Space Telescope.

  2. James L. Outtz (1947-2016).

    PubMed

    Zedeck, Sheldon; Cascio, Wayne

    2016-09-01

    This article memorializes James L. Outtz, who passed away March 26, 2016. For more than 40 years, Outtz was a leading researcher, practitioner, and consultant in the areas of hiring and promotion, employment discrimination, selection-test design and implementation, and legal issues pertaining to employment. He worked tirelessly to enhance opportunities for workforce diversity through greater inclusion of minorities and women. Another important focus was on strategies to minimize adverse impact through alternative approaches to selection. His work significantly influenced best practices in equal employment opportunity, and he was a highly sought-after legal-compliance consultant and testifying expert, advisor to courts, and participant on consent decrees with experts and lawyers from all sides of an issue. His efforts involved some of the most prominent corporations in America and most visible public-sector jurisdictions. In his final 2 years, he became president-elect of the Society for Industrial and Organizational Psychology (SIOP). (PsycINFO Database Record PMID:27571534

  3. James J. Jenkins (1923-2012).

    PubMed

    Foss, Donald J; Overmier, J Bruce

    2013-01-01

    Presents an obituary for James J. Jenkins. Jim Jenkins, fondly known as "J-cubed," was born on July 29, 1923, in St. Louis, Missouri. He attended William Jewell College but enlisted in the Army in 1942. He received a bachelor's degree in physics from the University of Chicago in 1944 as part of his training as a meteorologist. After serving in the South Pacific, he returned to William Jewell College, obtaining a bachelor's degree in psychology in 1947. Jenkins received a master's degree (1948) and a doctorate (1950) from the University of Minnesota under a giant in industrial psychology, Donald G. Paterson. He joined the Minnesota Psychology Department faculty upon graduation (turning down an offer from General Motors at triple the salary). Jenkins helped lead psychology's "cognitive revolution" from the second half of the 20th century into the present one. His work advanced multiple research areas: learning and memory, sentence processing, aphasia, speech perception, and perceptual organization. His remarkable combination of abilities led to nearly 200 scholarly publications and 500 conference and meeting presentations; multiple leadership positions, teaching awards, and professional accolades; and intense devotion from generations of students. PMID:23895612

  4. James F. T. Bugental (1915-2008).

    PubMed

    Schneider, Kirk J; Greening, Tom

    2009-01-01

    James F. T. Bugental died peacefully at age 92 at his Petaluma, California, home on September 18, 2008. Jim was a leading psychotherapist and a founding father, with Abraham Maslow and others, of humanistic psychology, or the "third force" (in contrast to psychoanalysis and behaviorism). Jim was also the creator, along with Rollo May, of existential-humanistic psychotherapy. Jim was born in Fort Wayne, Indiana, on Christmas Day in 1915. Jim earned his doctorate in 1948 from Ohio State University, where he was influenced by Victor Raimy and George Kelly. After a brief time on the University of California, Los Angeles (UCLA) faculty in psychology, Jim resigned in 1953 to found the first group practice of psychotherapy, Psychological Service Associates, with Alvin Lasko. With Abraham Maslow and others, Jim was a cofounder of the Journal of Humanistic Psychology (JHP) and the Association for Humanistic Psychology in 1961. Jim also wrote many books on the topic of psychotherapy during his lifetime. Jim was a great and bold spirit--his many writings and teachings are cherished today widely, and the field of psychology is much richer for his efforts. PMID:19203148

  5. Building the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2012-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes. It will be a large (6.6m) cold (50K) telescope launched into orbit around the second Earth-Sun Lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. JWST will make progress In almost every area of astronomy, from the first galaxies to form in the early universe to exoplanets and Solar System objects. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Near-Infrared Imager and Slitless Spectrograph will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. The observatory Is confirmed for launch in 2018; the design is complete and it is in its construction phase. Innovations that make JWST possible include large-area low-noise infrared detectors, cryogenic ASICs, a MEMS micro-shutter array providing multi-object spectroscopy, a non-redundant mask for interferometric coronagraphy and diffraction-limited segmented beryllium mirrors with active wavefront sensing and control. Recent progress includes the completion of the mirrors, the delivery of the first flight instruments and the start of the integration and test phase.

  6. Science with the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2012-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes. It will be a large (6.6m) cold (50K) telescope launched into orbit around the second Earth-Sun lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. The science goals for JWST include the formation of the first stars and galaxies in the early universe; the chemical, morphological and dynamical buildup of galaxies and the formation of stars and planetary systems. Recently, the goals have expanded to include studies of dark energy, dark matter, active galactic nuclei, exoplanets and Solar System objects. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Near-Infrared Imager and Slitiess Spectrograph will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. The observatory is confirmed for launch in 2018; the design is complete and it is in its construction phase. Recent progress includes the completion of the mirrors, the delivery of the first flight instrument(s) and the start of the integration and test phase.

  7. A Conversation with James J. Morgan

    NASA Astrophysics Data System (ADS)

    Morgan, James J.; Newman, Dianne K.

    2015-05-01

    In conversation with professor Dianne Newman, Caltech geobiologist, James "Jim" J. Morgan recalls his early days in Ireland and New York City, education in parochial and public schools, and introduction to science in Cardinal Hayes High School, Bronx. In 1950, Jim entered Manhattan College, where he elected study of civil engineering, in particular water quality. Donald O'Connor motivated Jim's future study of O2 in rivers at Michigan, where in his MS work he learned to model O2 dynamics of rivers. As an engineering instructor at Illinois, Jim worked on rivers polluted by synthetic detergents. He chose to focus on chemical studies, seeing it as crucial for the environment. Jim enrolled for PhD studies with Werner Stumm at Harvard, who mentored his research in chemistry of particle coagulation and oxidation processes of Mn(II) and (IV). In succeeding decades, until retirement in 2000, Jim's teaching and research centered on aquatic chemistry; major themes comprised rates of abiotic manganese oxidation on particle surfaces and flocculation of natural water particles, and chemical speciation proved the key.

  8. James Webb Space Telescope Orbit Determination Analysis

    NASA Technical Reports Server (NTRS)

    Yoon, Sungpil; Rosales, Jose; Richon, Karen

    2014-01-01

    The James Webb Space Telescope (JWST) is designed to study and answer fundamental astrophysical questions from an orbit about the Sun-EarthMoon L2 libration point, 1.5 million km away from Earth. Three mid-course correction (MCC) maneuvers during launch and early orbit phase and transfer orbit phase are required for the spacecraft to reach L2. These three MCC maneuvers are MCC-1a at Launch+12 hours, MCC-1b at L+2.5 days and MCC-2 at L+30 days. Accurate orbit determination (OD) solutions are needed to support MCC maneuver planning. A preliminary analysis shows that OD performance with the given assumptions is adequate to support MCC maneuver planning. During the nominal science operations phase, the mission requires better than 2 cmsec velocity estimation performance to support stationkeeping maneuver planning. The major challenge to accurate JWST OD during the nominal science phase results from the unusually large solar radiation pressure force acting on the huge sunshield. Other challenges are stationkeeping maneuvers at 21-day intervals to keep JWST in orbit around L2, frequent attitude reorientations to align the JWST telescope with its targets and frequent maneuvers to unload momentum accumulated in the reaction wheels. Monte Carlo analysis shows that the proposed OD approach can produce solutions that meet the mission requirements.

  9. James Webb Space Telescope Orbit Determination Analysis

    NASA Technical Reports Server (NTRS)

    Yoon, Sungpil; Rosales, Jose; Richon, Karen

    2014-01-01

    The James Webb Space Telescope (JWST) is designed to study and answer fundamental astrophysical questions from an orbit about the Sun-Earth/Moon L2 libration point, 1.5 million km away from Earth. This paper describes the results of an orbit determination (OD) analysis of the JWST mission emphasizing the challenges specific to this mission in various mission phases. Three mid-course correction (MCC) maneuvers during launch and early orbit phase and transfer orbit phase are required for the spacecraft to reach L2. These three MCC maneuvers are MCC-1a at Launch+12 hours, MCC-1b at L+2.5 days and MCC-2 at L+30 days. Accurate OD solutions are needed to support MCC maneuver planning. A preliminary analysis shows that OD performance with the given assumptions is adequate to support MCC maneuver planning. During the nominal science operations phase, the mission requires better than 2 cm/sec velocity estimation performance to support stationkeeping maneuver planning. The major challenge to accurate JWST OD during the nominal science phase results from the unusually large solar radiation pressure force acting on the huge sunshield. Other challenges are stationkeeping maneuvers at 21-day intervals to keep JWST in orbit around L2, frequent attitude reorientations to align the JWST telescope with its targets and frequent maneuvers to unload momentum accumulated in the reaction wheels. Monte Carlo analysis shows that the proposed OD approach can produce solutions that meet the mission requirements.

  10. SirR, a novel iron-dependent repressor in Staphylococcus epidermidis.

    PubMed

    Hill, P J; Cockayne, A; Landers, P; Morrissey, J A; Sims, C M; Williams, P

    1998-09-01

    In Staphylococcus epidermidis and Staphylococcus aureus, a number of cell wall- and cytoplasmic membrane-associated lipoproteins are induced in response to iron starvation. To gain insights into the molecular basis of iron-dependent gene regulation in the staphylococci, we sequenced the DNA upstream of the 3-kb S. epidermidis sitABC operon, which Northern blot analysis indicates is transcriptionally regulated by the growth medium iron content. We identified two DNA sequences which are homologous to elements of the Corynebacterium diphtheriae DtxR regulon, which controls, in response to iron stress, for example, production of diphtheria toxin, siderophore, and a heme oxygenase. Upstream of the sitABC operon and divergently transcribed lies a 645-bp open reading frame (ORF), which codes for a polypeptide of approximately 25 kDa with homology to the DtxR family of metal-dependent repressor proteins. This ORF has been designated SirR (staphylococcal iron regulator repressor). Within the sitABC promoter/operator region, we also located a region of dyad symmetry overlapping the transcriptional start of sitABC which shows high homology to the DtxR operator consensus sequence, suggesting that this region, termed the Sir box, is the SirR-binding site. The SirR protein was overexpressed, purified, and used in DNA mobility shift assays; SirR retarded the migration of a synthetic oligonucleotide based on the Sir box in a metal (Fe2+ or Mn2+)-dependent manner, providing confirmatory evidence that this motif is the SirR-binding site. Furthermore, Southern blot analysis of staphylococcal chromosomal DNA with the synthetic Sir box as a probe confirmed that there are at least five Sir boxes in the S. epidermidis genome and at least three in the genome of S. aureus, suggesting that SirR controls the expression of multiple target genes. Using a monospecific polyclonal antibody raised against SirR to probe Western blots of whole-cell lysates of S. aureus, S. carnosus, S. epidermidis