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Sample records for sir james crichton-browne

  1. Sir James Lighthill

    NASA Astrophysics Data System (ADS)

    Crighton, D. G.

    1999-05-01

    James Lighthill died on 17 July 1998, at the end of a ten-hour swim round the Channel Island of Sark. He had earlier, at age 49, been the first person ever to do this, and he was carrying out the swim for the seventh time when the exertion revealed a mitral valve weakness which had never been diagnosed, and which led to his sudden death in the water. The swim was one of many long ‘adventure swims’ which Lighthill liked to take, all characterized by strong tidal currents and often heavy seas. And Lighthill took much pleasure through exercising his comprehensive understanding of fluid mechanics first in preparing for them through study of local conditions and then in adapting his performance when, as often, he found that in practice the currents were not as charted and, in fact, often more treacherous.

  2. Sir James Paget and his contributions to pathology.

    PubMed Central

    Turk, J. L.

    1995-01-01

    Sir James Paget's Lectures on Surgical Pathology, published in 1853, was based on Lectures given at the Royal College of Surgeons of England in the previous six years. It makes use of the pathological material collected by John Hunter in the late eighteenth century which was housed in the College. It expands the principles of pathophysiology enunciated by Hunter using microscopic observations. The first half of the book covers mainly inflammation and repair; the second is involved in a description of tumours with particular emphasis on the difference between benign and malignant growths. This book indicates a concept of pathology before the realization of the role of infectious organisms. However, there is some inkling of the contagious nature of syphilis and variola following on Hunter's work. The concept, current at that time, that tuberculosis was related to cancer is expressed. This work acts as a bridge between the pathology of John Hunter and that of the present time. Images Figure 1 PMID:8652365

  3. Experimental tectonics: from Sir James Hall to the present

    NASA Astrophysics Data System (ADS)

    Ranalli, Giorgio

    2001-09-01

    The subject of experimental tectonics is the study of geodynamic processes by means of laboratory scale models. The first roughly scaled experiments were performed by Sir James Hall about two centuries ago, in the intellectual atmosphere generated by the appearance of Hutton's Theory of the Earth (Hutton, J., 1795. Theory of the Earth, with Proofs and Illustrations, Vols. I & II. Cadell & Davies, Edinburgh). Their aim was to test the hypothesis that the folding of originally horizontal strata is the result of lateral compression. The idea to test hypotheses by laboratory experiments had already been applied by Hall to petrological problems (crystallization and melting) not involving scaling. Interestingly, however, he constructed a scale model of a Gothic cathedral, using a line of reasoning parallel to that used in his tectonic experiments. From these beginnings, the theory and practice of scale models have grown to become an important part of an integrated approach to the study of geodynamics. One topic which is at present the focus of much attention is the choice of model materials correctly scaling the temperature dependence of lithospheric materials. As an example, a brief discussion is offered of two geodynamic problems where the application of scale models is proving very fruitful: the initiation and time-history of subduction of oceanic and continental lithosphere, and the tectonic evolution of orogenic wedges.

  4. Sir James Mackenzie: from auricular paralysis and nodal rhythm to auricular fibrillation.

    PubMed

    Lippi, Donatella; Mascia, Giuseppe; Padeletti, Luigi

    2011-09-01

    The aim of this paper is to underline the role of Sir James Mackenzie in stating that atrial fibrillation is a distinct and clinically important arrhythmia and that it is a common condition in patients with cardiac disease. Around 1900, a few clinical researchers were dealing with cardiac arrhythmias with the use of arterial and venous pulse tracings. Sir James Mackenzie, who has been one of the fathers of modern cardiology, introduced registration of the venous pulse at the bedside using the clinical polygraph he had invented. He applied the results of his experimental and clinical discoveries to the explanation of many kinds of arrhythmias before ECG introduction. In our paper, we have especially considered the three steps of his approach to atrial fibrillation, the first two developed in the pre-ECG era. The invention of an instrument of precision, the electrocardiograph, revolutionized the diagnosis of heart disease and catalyzed the formation of cardiology as a specialty. PMID:21476085

  5. Sir James Mouat, VC KCB FRCS (1815-1899): winner of the first medical Victoria Cross.

    PubMed

    Lawrenson, Ross

    2004-11-01

    Sir James Mouat was the first of 36 doctors to win the Victoria Cross. Born in Kent in 1815, he was educated at University College London before joining the army. After service in India and Ireland he joined the 6th Dragoon Guards as regimental surgeon and served with them throughout the Crimean War. He won his VC at the Battle of Balaclava. After the Crimean War he was appointed principal medical officer to the British troops in the New Zealand Wars. After serving in New Zealand he returned to England and became Inspector General of Hospitals. Surgeon General Mouat retired on 28 April 1876. He was appointed an honorary surgeon to the Queen in 1888, and a Knight Commander of the Order of the Bath in 1894. He died of a stroke on 4 January 1899 at the age of 83. PMID:15486614

  6. Sir James Edward Smith (1759-1828) MD FRS, botanist, co-founder of the Linnean Society of London.

    PubMed

    Hawgood, Barbara J

    2009-05-01

    James Edward Smith's interest in botany led him to enter medicine at Edinburgh in 1781. Smith was continuing his medical studies in London when Sir Joseph Banks (1743-1820) suggested to him that he should purchase the collection of the famous Swedish naturalist Carl Linnaeus that had just been offered to Banks. Smith bought the Linnean Collection and Library in 1784. In 1786 he was awarded the degree of Doctor of Medicine from Leiden. In 1788 Smith, with two associates, founded the Linnean Society of London and became President for life. Smith turned from medicine to natural history as a lecturer and writer. During his lifetime he produced numerous botanical works of high value, including The English Flora (1824-28), and he did much to popularize botany. PMID:19401517

  7. Sir James Jeans

    NASA Astrophysics Data System (ADS)

    Milne, E. A.

    2013-09-01

    Memoir by S. C. Roberts; 1. Merchant Taylor's and Cambridge; 2. Princeton, 1905-9; 3. Return to England. The Adams Prize essay, 1909-19; 4. Secretary of the Royal Society, 1919-29; 5. Popular exposition, 1929-30; 6. Later years, 1931-46; 7. Science in Jeans's boyhood; 8. The partition of energy; 9. Rotating fluid masses; 10. Star clusters; 11. The equilibrium of the stars; 12. Jeans and philosophy; Bibliography; Index.

  8. James Bay

    Atmospheric Science Data Center

    2013-04-17

    article title:  First Views of James Bay, Canada     ... show the winter landscape of James Bay, Ontario, Canada from three of the instrument's nine cameras. The image at left captures the opening ... down. The image on the right was taken seven minutes after the first image from the most oblique, aftward-viewing camera. "These ...

  9. James Bay

    Atmospheric Science Data Center

    2013-04-17

    article title:  First Light over James Bay     View Larger Image MISR "First light", 16:40 UTC, 24 February 2000 . This is the first image of Earth's ... the line of flight. At the top of the image, the dark-to-light transition captures the opening of the MISR cover. Progressing southward, ...

  10. Sir Alec Clegg

    ERIC Educational Resources Information Center

    Brighouse, Tim

    2008-01-01

    This article is a personal view of the career of Sir Alec Clegg. It outlines some of Clegg's achievements in the West Riding, and why he was so influential on those that he worked with. Finally, it retells one of Alec Clegg's favourite stories "The fable of Fred".

  11. Influenza SIRS with Minimal Pneumonitis

    PubMed Central

    Erramilli, Shruti; Mannam, Praveen; Manthous, Constantine A.

    2016-01-01

    Although systemic inflammatory response syndrome (SIRS) is a known complication of severe influenza pneumonia, it has been reported very rarely in patients with minimal parenchymal lung disease. We here report a case of severe SIRS, anasarca, and marked vascular phenomena with minimal or no pneumonitis. This case highlights that viruses, including influenza, may cause vascular dysregulation causing SIRS, even without substantial visceral organ involvement.

  12. William James's Moral Theory

    ERIC Educational Resources Information Center

    Cooper, Wesley

    2003-01-01

    James's moral theory, primarily as set out in "The Moral Philosopher and the Moral Life" (in his "The Will To Believe" (1897)), is presented here as having a two-level structure, an empirical or historical level where progress toward greater moral inclusiveness is central, and a metaphysical or end-of-history level--James's "kingdom of…

  13. The demographic work of Sir William Wilde.

    PubMed

    Froggatt, P

    2016-05-01

    This paper argues that Sir William Wilde was indeed a pioneering demographer. It also describes the unveiling of the plaque commemorating Sir William Wilde at his home, 1, Merrion Square, Dublin on the 28 October 1971. PMID:27083459

  14. New Zealand SIR-B science investigations

    NASA Technical Reports Server (NTRS)

    Collins, M. A.; Oliver, P. J.; Cochrane, G. R.; Cole, J.; Coombs, D. S.; Barnes, E. J.; Ching, N. P.; Bennets, R. L.; Stephens, P. H.; Laing, A. K.

    1984-01-01

    It is proposed that shuttle imaging radar (SIR) data be used to study unusual geological features of New Zealand. Particular attention is planned for geological faults. SIR-B imagery is to be compared with LANDSAT multispectral imagery. Three other investigations which are to use SIR data are discussed. An ocean eddy is to be studied from a correlation of SIR-B and advanced very high resolution radiometer imagery. Timber volume is to be assessed by determining the age and size of pine forests from SIR-B data. Soil moisture is to be investigated by comparing SIR-B data with simultaneous gravimetric data. Land cover in a region already subjected to intensive investigation using LANDSAT and aircraft scanner data is to be discriminated by SIR-B data.

  15. James Joule and meteors

    NASA Astrophysics Data System (ADS)

    Hughes, David W.

    1989 was the hundredth anniversary of the death of James Prescott Joule, the Prescott being his mother's family name and the Joule, rhyming with cool, originating from the Derbyshire village of Youlgreave. Joule is rightly famous for his experimental efforts to establish the law of conservation of energy, and for the fact that J, the symbol known as the mechanical equivalent of heat, is named after him. Astronomically his "light has been hidden under a bushel". James Joule had a major influence on the physics of meteors.

  16. SIR-B iceberg observation

    NASA Astrophysics Data System (ADS)

    Carsey, Frank

    The Shuttle Imaging Radar (SIR) made its second flight (called SIR-B) in October 1984. Among the 44 science projects that it was due to support were two ice-related studies, one concerning the behavior of the sea ice of the southern ocean pack and marginal ice zones and another concerning the detectability of icebergs and other navigational hazards off the east coast of Canada. The southern ocean sea ice team was led by F. Carsey of the Jet Propulsion Laboratory (JPL), Pasadena, Calif., and consisted of B. Holt (JPL), S. Martin (University of Washington, Seattle), L. Mc-Nutt (Radarsat, Ottawa), D.A. Rothrock (Polar Science Center, Seattle), W.F. Weeks (U.S. Army Cold Regions Research and Engineering Laboratory, Hanover, N.H.), and V. Squire (Canada Centre for Remote Sensing (CCRS), Ottawa); the iceberg team was led by A.L. Gray (CCRS) and consisted of J.Princz, C.E. Livingstone, R.K. Hawkins, M. Wong (all of CCRS), D. Pearson (Petro-Canada Exploration, Calgary, Canada), J. Gower (Institute of Ocean Sciences, Sydney, Canada), T.F. Mullane, and R.O. Ramseier (both of the Atmospheric Environment Service, Ottawa). As it happened, the SIR-B mission experienced difficulty with its data link to a geostationary relay satellite and with the SIR-B radar transmitter, with the consequences that the total amount of data taken was only about one fifth of what was planned and that the data quality was impaired in comparison to what had been anticipated. The result was that no iceberg synthetic aperture radar (SAR) images off the Canadian coast and very limited sea ice SAR images in the southern ocean were acquired; however, a few interesting SAR images of the southern ocean icebergs were acquired, and a few of these are shown in Figure 1.

  17. A nonlinear SIR with stability

    NASA Astrophysics Data System (ADS)

    Trisilowati, Darti, I.; Fitri, S.

    2014-02-01

    The aim of this work is to develop a mathematical model of a nonlinear susceptible-infectious-removed (SIR) epidemic model with vaccination. We analyze the stability of the model by linearizing the model around the equilibrium point. Then, diphtheria data from East Java province is fitted to the model. From these estimated parameters, we investigate which parameters that play important role in the epidemic model. Some numerical simulations are given to illustrate the analytical results and the behavior of the model.

  18. James Ferguson remembered

    NASA Astrophysics Data System (ADS)

    Davenhall, Clive

    2012-03-01

    The year 2010 marked the three hundredth anniversary of the birth of the astronomer, author and lecturer James Ferguson (1710-1776). Subsequently I visited the site of the churchyard where Ferguson is buried. He is mentioned in a plaque on the site and I thought that the details might be of interest.

  19. How James Wood Works

    ERIC Educational Resources Information Center

    Goldstein, Evan R., Comp.

    2008-01-01

    Reading through news-media clippings about James Wood, one might reasonably conclude that "pre-eminent critic" is his official job title. In fact, Wood is a staff writer for "The New Yorker" and a professor of the practice of literary criticism at Harvard University. But at a time when there is much hand-wringing about the death of the…

  20. Reply to James Muir

    ERIC Educational Resources Information Center

    White, John

    2004-01-01

    In "EPAT", vol. 36, no. 1, 2004, James Muir takes the author and fellow philosophers of education to task for their ignorance of the history of philosophy of education. "[T]oo many currently influential educationists, Professor White in particular, are literally unaware that educational philosophy has a history more than three hundred years in…

  1. William James's Talks about Teaching

    ERIC Educational Resources Information Center

    Brewer, Charles L.

    2003-01-01

    More than 100 years after it was published, William James's (1899/1939) book, "Talks to Teachers on Psychology," is relevant and helpful for teachers and those who aspire to teach. In this article, I highlight certain memorable points in "Talks" and relate them to James's (1890) classic work, "The Principles of Psychology." Many of James's…

  2. William James on Teaching Democracy.

    ERIC Educational Resources Information Center

    Miller, Joshua

    1998-01-01

    Analyzes philosopher William James' writings on political representation and participatory democracy. Although he argued in favor of democratic principles, James also strongly supported the role of a well-educated elite serving as leaders. Attempts to reconcile these contradictory positions and considers James' influence on the development of…

  3. A fractional-order infectivity SIR model

    NASA Astrophysics Data System (ADS)

    Angstmann, C. N.; Henry, B. I.; McGann, A. V.

    2016-06-01

    Fractional-order SIR models have become increasingly popular in the literature in recent years, however unlike the standard SIR model, they often lack a derivation from an underlying stochastic process. Here we derive a fractional-order infectivity SIR model from a stochastic process that incorporates a time-since-infection dependence on the infectivity of individuals. The fractional derivative appears in the generalised master equations of a continuous time random walk through SIR compartments, with a power-law function in the infectivity. We show that this model can also be formulated as an infection-age structured Kermack-McKendrick integro-differential SIR model. Under the appropriate limit the fractional infectivity model reduces to the standard ordinary differential equation SIR model.

  4. The SIR-B science plan

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The Shuttle Imaging Radar-B (SIR-B) will be the third in a series of spaceborne SAR experiments conducted by NASA which began with the 1978 launch of SEASAT and continued with the 1981 launch of SIR-A. Like SEASAT and SIR-A, SIR-B will operate at L-band and will be horizontally polarized. However, SIR-B will allow digitally processed imagery to be acquired at selectable incidence angles between 15 and 60 deg, thereby permitting, for the first time, parametric studies of the effect of illumination geometry on SAR image information extraction. This document presents a science plan for SIR-B and serves as a reference for the types of geoscientific, sensor, and processing experiments which are possible.

  5. Parallelization of the SIR code

    NASA Astrophysics Data System (ADS)

    Thonhofer, S.; Bellot Rubio, L. R.; Utz, D.; Jurčak, J.; Hanslmeier, A.; Piantschitsch, I.; Pauritsch, J.; Lemmerer, B.; Guttenbrunner, S.

    A high-resolution 3-dimensional model of the photospheric magnetic field is essential for the investigation of small-scale solar magnetic phenomena. The SIR code is an advanced Stokes-inversion code that deduces physical quantities, e.g. magnetic field vector, temperature, and LOS velocity, from spectropolarimetric data. We extended this code by the capability of directly using large data sets and inverting the pixels in parallel. Due to this parallelization it is now feasible to apply the code directly on extensive data sets. Besides, we included the possibility to use different initial model atmospheres for the inversion, which enhances the quality of the results.

  6. James R. Thompson

    NASA Technical Reports Server (NTRS)

    1986-01-01

    James R. Thompon served as director of the Marshall Space Flight Center from September 29, 1986 until July 6, 1989, when he was appointed as NASA Deputy Administrator. Prior to his tenure as Marshall's Director, Thompson served from March to June 1986 as the vice-chairman of the NASA task force investigating the cause of the Space Shuttle Challenger accident. He was credited with playing a significant role in returning the Space Shuttle to flight following the Challenger disaster.

  7. Stability of stochastic switched SIRS models

    NASA Astrophysics Data System (ADS)

    Meng, Xiaoying; Liu, Xinzhi; Deng, Feiqi

    2011-11-01

    Stochastic stability problems of a stochastic switched SIRS model with or without distributed time delay are considered. By utilizing the Lyapunov methods, sufficient stability conditions of the disease-free equilibrium are established. Stability conditions about the subsystem of the stochastic switched SIRS systems are also obtained.

  8. The SIR-2 Experiment on Chandrayaan-1

    NASA Astrophysics Data System (ADS)

    Mall, U.; Nathues, A.; SIR-2 Collaboration

    2009-04-01

    The SIR-2 experiment, flying on the Indian Chandrayaan-1 mission to the Moon, is a near-infrared point spectrometer of the second-generation built by a European collaboration around the Max-Planck Institute for Solar System Research. SIR-2 has been designed based on the heritage of the SIR Technology experiment on ESA's SMART-1 mission, in order to investigate the mineralogical composition of the Moon for a period of two years. The SIR-2 instrument, which will operate in conjunction with the Indian Hyper-Spectral Imaging spectrometer (HySI) on board Chandrayaan-1, will cover, together with HySi, a combined spectral range of 0.4 to 2.4 m. We will explain the SIR-2 experiment and report on the performance of the instrument during its commissioning phase to deliver high spatial and spectral near-infrared data from its first 100 km polar orbits around the Moon.

  9. Joint Scientific Papers of James Prescott Joule

    NASA Astrophysics Data System (ADS)

    Prescott Joule, James

    2011-06-01

    Experiments and observations on the mechanical powers of electro-magnetism, steam, and horses with Dr. Scoresby; On atomic volume and specific gravity with Sir Lyon Playfair; On the thermal effects experienced by air in rushing through small apertures with Sir Wm. Thomson; On the thermal effects of fluids in motion with Sir Wm. Thomson; On the thermal effects of elastic fluids with Sir Wm. Thomson; On the thermal effects of fluids in motion with Sir Wm. Thomson.

  10. Sir William Wilde: an enlightened editor.

    PubMed

    O'Doherty, M

    2016-05-01

    This paper examines Sir William Wilde's peculiar genius as editor, his contribution to the Irish Journal of Medical Science in ensuring its endurance and making it a treasure-house of the history of medicine in Ireland. PMID:26969455

  11. Stability of SIRS system with random perturbations

    NASA Astrophysics Data System (ADS)

    Lu, Qiuying

    2009-09-01

    Epidemiological models with bilinear incidence rate λSI usually have an asymptotically stable trivial equilibrium corresponding to the disease-free state, or an asymptotically stable non-trivial equilibrium (i.e. interior equilibrium) corresponding to the endemic state. In this paper, we consider an epidemiological model, which is an SIRS model with or without distributed time delay influenced by random perturbations. We present the stability conditions of the disease-free equilibrium of the associated stochastic SIRS system.

  12. The SIR-B science investigations plan

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Shuttle Imaging Radar-B (SIR-B) is the second synthetic aperture radar (SAR) to be flown on the National Aeronautics and Space Administration's Space Transportation System (Shuttle). It is the first spaceborne SAR to feature an antenna that allows acquisition of multiincidence angle imagery. An international team of scientists will use SIR-B to conduct investigations in a wide range of disciplines. The radar, the mission, and the investigations are described.

  13. James E. Keeler Pioneer Astrophysicist.

    ERIC Educational Resources Information Center

    Osterbrock, Donald E.

    1979-01-01

    Gives a short biography of James E. Keeler, and describes some of his outstanding discoveries, and his pioneering work in observational research where he applied physical methods to the analysis of planets, stars and nebulae. (GA)

  14. Sir Hans Sloane (1660–1735): his life and legacy

    PubMed Central

    Hawkins, Stanley A

    2010-01-01

    Sir Hans Sloane was born in Killyleagh, Co Down, the seventh and last son of Alexander Sloane. His father, who was of Scottish ancestry, had a long association with James Hamilton, Earl of Clanbrassil who had acquired the castle in Killyleagh and extensive estates in east Down. The Hamilton family took an interest in the education of the Sloane children, and much of the early tuition of Hans was conducted within the library of Killyleagh Castle. In 1679 he moved to London to study medicine and botany. In 1683, he continued his studies in Paris and Montpellier, and graduated from the University of Orange. On his return to London, he became a protégé of Thomas Sydenham. In 1687 he was appointed physician to the Duke of Albemarle and surgeon to the West Indies fleet. While in Jamaica he added countless specimens to his collections, continuing a lifetime passion. He also invented milk chocolate there. Following the untimely death of the duke, he returned to London and built up a fashionable medical practice. He married Elizabeth Langley, heiress of a wealthy city alderman, and widow of a sugar planter in Jamaica. They set up house in Great Russell Street. The family home accommodated his burgeoning collections of books, specimens and curiosities. In 1685 he was elected a Fellow of the Royal Society, later becoming the honorary secretary and president. Following his death, his collections were bought for the nation and formed the foundation of the British Museum. PMID:20844729

  15. Sir Charles James Martin MB FRS: Australian serpents and Indian plague, one-hundred years ago.

    PubMed

    Hawgood, B J

    1997-07-01

    In 1891 as Demonstrator in Physiology at the University of Sydney, Charles Martin began the first systematic study of the chemical and physiological properties of the venoms of the Australian elapid species, Pseudechis porphyriacus and Notechis scutatus. Two major constituents were detected: a large coagulable protein which was associated with intravascular clotting, and a small proteinaceous molecule, an albumose, associated with neurotoxicity. Martin designed and constructed a high-pressure gelatin membrane ultrafilter for fractionation of venom. His studies indicated that certain physiological actions and clinical symptoms were related to the faster rate of diffusion within the tissue space of a neurotoxic constituent relative to a clotting constituent. Extending this work to toxin-antitoxin relationships, Martin provided evidence that antitoxin was a large molecule with slow diffusibility in tissue and advised the administration of curative serum (including diphtheria antitoxin) by intravenous injection. In 1903, Martin returned to London as Director of the Lister Institute of Preventive Medicine. He was soon involved in the planning of scientific work to be undertaken by the Commission for Investigation of Plague in India as the disease continued to ravage the subcontinent. Detailed epidemiological studies of possible factors involved in the spread of Pasteurella pestis showed, unequivocally, that infected rat fleas were the vector of transmission from rats to humans. PMID:9247999

  16. Tectonic geomorphology of the Andes with SIR-A and SIR-B

    NASA Technical Reports Server (NTRS)

    Bloom, Arthur L.; Fielding, Eric J.

    1986-01-01

    Data takes from SIR-A and SIR-B (Shuttle Imaging Radar) crossed all of the principal geomorphic provinces of the central Andes between 17 and 34 S latitude. In conjunction with Thematic Mapping images and photographs from hand-held cameras as well as from the Large Format Camera that was flown with SIR-B, the radar images give an excellent sampling of Andean geomorphology. In particular, the radar images show new details of volcanic rocks and landforms of late Cenozoic age in the Puna, and the exhumed surfaces of tilted blocks of Precambrian crystalline basement in the Sierras Pampeanas.

  17. Shuttle Imaging Radar-C (SIR-C): Executive summary

    NASA Technical Reports Server (NTRS)

    1983-01-01

    The scientific and technological objectives of the Shuttle Imaging Radar-C (SIR-C) Project are reviewed. Information regarding the implementation philosophy and approach, and the relationship of the project to the overall SIR program is also provided.

  18. SIR technology helps ensure safe landings for NASA

    NASA Astrophysics Data System (ADS)

    Kratochvil, Gary; Fenner, Thomas; Benson, Richard

    1992-12-01

    The use of a subsurface interface radar (SIR) system to ensure that lake-bed runways are free of unseen fissures and voids is described. SIR systems nonintrusively detect anomalies underground or embedded in concrete and other man-made materials. The effectiveness of an SIR system is influenced by the type of soil, with best results obtained for dry, sandy soil. Results of the application of SIR technology to Edwards AFB runways are summarized.

  19. Sir Sandford Fleming College Repositioning Strategies Report.

    ERIC Educational Resources Information Center

    Sir Sandford Fleming Coll., Peterborough (Ontario).

    This report describes repositioning strategies undertaken by Sir Sandford Fleming College, in Ontario, to respond to changing student demographics, educational demands, and reduced funding. Following opening remarks by the college president providing an overview of the strategies and the use of all-staff meetings to generate responses from the…

  20. Dr James Currie (1756-1805): Liverpool physician, campaigner, hydrotherapist and man of letters.

    PubMed

    Halliday, Stephen

    2006-02-01

    James Currie was born and educated in Scotland but spent most of his professional life in Liverpool, where, as physician to the Liverpool Infirmary, he campaigned against the unsanitary living conditions in the rapidly growing port. He was an early advocate of water cures for fever and other maladies, on which subject he carried out experiments and published a seminal work. He was a pioneer in the use of the clinical thermometer. He was also an early advocate of the abolition of slavery and a man with literary and scientific interests, which brought him into contact with many of his most distinguished contemporaries. These included Erasmus Darwin (1731-1802), William Wilberforce (1759-1833), Sir Walter Scott (1771-1832), Sir Joseph Banks (1743-1820) and Robert Burns (1759-96), of whose poetry Currie was the first editor. He died in August 1805 at Sidmouth in Devon, whose parish church carries his memorial. PMID:16435032

  1. Cooperative stabilization of the SIR complex provides robust epigenetic memory in a model of SIR silencing in Saccharomyces cerevisiae

    PubMed Central

    Sneppen, Kim; Dodd, Ian B

    2015-01-01

    How alternative chromatin-based regulatory states can be made stable and heritable in order to provide robust epigenetic memory is poorly understood. Here, we develop a stochastic model of the silencing system in Saccharomyces cerevisiae that incorporates cooperative binding of the repressive SIR complex and antisilencing histone modifications, in addition to positive feedback in Sir2 recruitment. The model was able to reproduce key features of SIR regulation of an HM locus, including heritable bistability, dependence on the silencer elements, and sensitivity to SIR dosage. We found that antisilencing methylation of H3K79 by Dot1 was not needed to generate these features, but acted to reduce spreading of SIR binding, consistent with its proposed role in containment of silencing. In contrast, cooperative inter-nucleosome interactions mediated by the SIR complex were critical for concentrating SIR binding around the silencers in the absence of barriers, and for providing bistability in SIR binding. SIR-SIR interactions magnify the cooperativity in the Sir2-histone deacetylation positive feedback reaction and complete a double-negative feedback circuit involving antisilencing modifications. Thus, our modeling underscores the potential importance of cooperative interactions between nucleosome-bound complexes both in the SIR system and in other chromatin-based complexes in epigenetic regulation. PMID:25830651

  2. Cooperative stabilization of the SIR complex provides robust epigenetic memory in a model of SIR silencing in Saccharomyces cerevisiae.

    PubMed

    Sneppen, Kim; Dodd, Ian B

    2015-01-01

    How alternative chromatin-based regulatory states can be made stable and heritable in order to provide robust epigenetic memory is poorly understood. Here, we develop a stochastic model of the silencing system in Saccharomyces cerevisiae that incorporates cooperative binding of the repressive SIR complex and antisilencing histone modifications, in addition to positive feedback in Sir2 recruitment. The model was able to reproduce key features of SIR regulation of an HM locus, including heritable bistability, dependence on the silencer elements, and sensitivity to SIR dosage. We found that antisilencing methylation of H3K79 by Dot1 was not needed to generate these features, but acted to reduce spreading of SIR binding, consistent with its proposed role in containment of silencing. In contrast, cooperative inter-nucleosome interactions mediated by the SIR complex were critical for concentrating SIR binding around the silencers in the absence of barriers, and for providing bistability in SIR binding. SIR-SIR interactions magnify the cooperativity in the Sir2-histone deacetylation positive feedback reaction and complete a double-negative feedback circuit involving antisilencing modifications. Thus, our modeling underscores the potential importance of cooperative interactions between nucleosome-bound complexes both in the SIR system and in other chromatin-based complexes in epigenetic regulation. PMID:25830651

  3. John James Audubon & the Turkey

    ERIC Educational Resources Information Center

    Hinshaw, Craig

    2012-01-01

    In the first half of the 1800s, John James Audubon roamed the wilds of America attempting to draw all the birds in their natural habitat. He published his life-sized paintings in a huge book entitled "Birds of America." Audubon developed a unique system of depicting the birds in natural poses, such as flying. After shooting the bird, he would wire…

  4. James Frey: Feelings as Facts

    ERIC Educational Resources Information Center

    Travis, Trysh

    2006-01-01

    James Frey, author of the book "A Million Little Pieces" is accused of embellishing and/or fabricating elements of his story, a graphic but supposedly honest, depiction of his struggle with drugs and alcohol. More and more college students who are caught plagiarizing believe, as Frey seems to, that as long as one agrees with the authors one…

  5. Foreword: Sir John Pendry FRS Sir John Pendry FRS

    NASA Astrophysics Data System (ADS)

    Inglesfield, John; Echenique, Pedro

    2008-07-01

    scattering is much weaker, and this allowed him to develop a method of successive approximation. The material and the calculation are cut up into a series of atomic slices, and the electronic structure solved without approximation in each slice. Being two-dimensional, this was much more manageable than a full three-dimensional calculation. Then the slices could be put together by a sort of perturbation theory to calculate the scattering current as a function of energy along each of the reciprocal lattice 'rods' allowed by the surface periodicity. John didn't just stop at having solved the problem in principle, he also developed a suite of computer codes to do the job in a routine way. He even published the code for all to use, and I believe that to the present day the calculations are still done effectively in the same way. Without the calculations, one cannot interpret the data in terms of a surface atomic structure. Effectively one is doing a computer experiment in parallel to the laboratory experiment, and one fiddles more or less systematically with the surface structure until one gets agreement between the simulations and the laboratory data. One of the things that John noticed was that the process of photoemission (UPS) from a surface is rather similar, and can be calculated in an analogous way. This suddenly became very important because the new synchrotron at Daresbury was about to become operational, pumping out billions of photons for solid state research. Sam Edwards (now Sir Sam) was head of SRC (forerunner of EPSRC) at the time and recognised the problem of interpreting all the data that the machine would provide. And after UPS would come EXAFS, and after that XANES and all the rest of the alphabet soup. With that foresight, unusual at the time, John Pendry was appointed to head the theory group at Daresbury. Previously the theoreticians had revolved around the nuclear physics accelerator, and John had to turn it completely around and refocus it, which he did

  6. Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast

    PubMed Central

    Hannan, Abdul; Abraham, Neethu Maria; Goyal, Siddharth; Jamir, Imlitoshi; Priyakumar, U. Deva; Mishra, Krishnaveni

    2015-01-01

    Silent information regulator 2 (Sir2), the founding member of the conserved sirtuin family of NAD+-dependent histone deacetylase, regulates several physiological processes including genome stability, gene silencing, metabolism and life span in yeast. Within the nucleus, Sir2 is associated with telomere clusters in the nuclear periphery and rDNA in the nucleolus and regulates gene silencing at these genomic sites. How distribution of Sir2 between telomere and rDNA is regulated is not known. Here we show that Sir2 is sumoylated and this modification modulates the intra-nuclear distribution of Sir2. We identify Siz2 as the key SUMO ligase and show that multiple lysines in Sir2 are subject to this sumoylation activity. Mutating K215 alone counteracts the inhibitory effect of Siz2 on telomeric silencing. SUMO modification of Sir2 impairs interaction with Sir4 but not Net1 and, furthermore, SUMO modified Sir2 shows predominant nucleolar localization. Our findings demonstrate that sumoylation of Sir2 modulates distribution between telomeres and rDNA and this is likely to have implications for Sir2 function in other loci as well. PMID:26319015

  7. Oscillations in SIRS model with distributed delays

    NASA Astrophysics Data System (ADS)

    Gonçalves, S.; Abramson, G.; Gomes, M. F. C.

    2011-06-01

    The ubiquity of oscillations in epidemics presents a long standing challenge for the formulation of epidemic models. Whether they are external and seasonally driven, or arise from the intrinsic dynamics is an open problem. It is known that fixed time delays destabilize the steady state solution of the standard SIRS model, giving rise to stable oscillations for certain parameters values. In this contribution, starting from the classical SIRS model, we make a general treatment of the recovery and loss of immunity terms. We present oscillation diagrams (amplitude and period) in terms of the parameters of the model, showing how oscillations can be destabilized by the shape of the distributions of the two characteristic (infectious and immune) times. The formulation is made in terms of delay equations which are both numerically integrated and linearized. Results from simulations are included showing where they support the linear analysis and explaining why not where they do not. Considerations and comparison with real diseases are presented along.

  8. Sir Bernard Lovell (1913-2012)

    NASA Astrophysics Data System (ADS)

    Argo, Megan

    2013-01-01

    Sir Bernard Lovell, founder and first Director of Jodrell Bank Observatory (UK), died on August 6th, 2012, at the age of 98. Lovell was one of the pioneers of radio astronomy. Much of his observational work in the early days of the Observatory focused on radio meteors. Using ex-army radar equipment, Lovell and his colleagues recorded the spectacular Draconid storm of October 1946 and went on to publish many papers in the field, settling some of the big arguments of the time. Sir Bernard's legacy is immense, extending from his wartime work on military radar systems to his pioneering contributions to radio astronomy, and including his dedication to education and public engagement with scientific research.

  9. SIR: Stokes Inversion based on Response functions

    NASA Astrophysics Data System (ADS)

    Ruiz Cobo, B.; del Toro Iniesta, J. C.

    2012-12-01

    SIR is a general-purpose code capable of dealing with gradients of the physical quantities with height. It admits one and two-component model atmospheres. It allows the recovery of the stratification of the temperature, the magnetic field vector, and the line of sight velocity through the atmosphere, and the micro- and macroturbulence velocities - which are assumed to be constant with depth. It is based on the response functions, which enter a Marquardt nonlinear least-squares algorithm in a natural way. Response functions are calculated at the same time as the full radiative transfer equation for polarized light is integrated, which determines values of many free parameters in a reasonable computation time. SIR demonstrates high stability, accuracy, and uniqueness of results, even when simulated observations present signal-to-noise ratios of the order of the lowest acceptable values in real observations.

  10. Magic, Mind Control, and the Body Electric: "Materia Medica" in Sir Walter Scott's Library at Abbotsford.

    PubMed

    Levy, Lindsay

    2014-01-01

    This chapter examines the medical texts, or "Materia Medica", held by Sir Walter Scott in his library at Abbotsford. While the vast majority of Scott's medical texts are antiquarian, his library also contains rare tracts and ephemera relating to the medical practice of the infamous quack, Dr James Graham (1745-94), and the Burke and Hare controversy of 1828 and its aftermath. Examining Scott's holdings of medical texts in relation to his own health and that of his family and friends, it is argued that the lack of contemporary medical self-help texts in his library is striking and indicative of his stoical attitude towards health, despite his clear interest in medical culture. PMID:27132356

  11. The Scientific Papers of James Clerk Maxwell

    NASA Astrophysics Data System (ADS)

    Clerk Maxwell, James; Niven, W. D.

    2011-01-01

    27. On the viscosity or internal friction of air and other gases; 28. On the dynamical theory of gases; 29. On the theory of the maintenance of electric currents by mechanical work without the use of permanent magnets; 30. On the equilibrium of a spherical envelope; 31. On the best arrangement for producing a pure spectrum on a screen; 32. The construction of stereograms of surfaces; 33. On reciprocal diagrams in space and their relation to Airy's function of stress; 34. On governors; 35. Experiment in magneto-electric induction; 36. On a method of making a direct comparison of electrostatic with electromagnetic force; 37. On the cyclide; 38. On a bow seen on the surface of ice; 39. On reciprocal figures, frames, and diagrams of forces; 40. On the displacement in a case of fluid motion; 41. Address to the mathematical and physical sections of the British Association, 1870; 42. On colour-vision at different points of the retina; 43. On hills and dales; 44. Introductory lecture on experimental physics; 45. On the solution of electrical problems by the transformation of conjugate functions; 46. On the mathematical classification of physical quantities; 47. On colour vision; 48. On the geometrical mean distance of two figures on a plane; 49. On the induction of electric currents in an infinite plane sheet of uniform conductivity; 50. On the condition that, in the transformation of any figure by curvilinear co-ordinates in three dimensions, every angle in the new figure shall be equal to the corresponding angle in the original figure; 51. Reprint of Papers on electrostatics and magnetism. By Sir W. Thomson. (Review); 52. On the proof of the equations of motion of a connected system; 53. On a problem in the calculus of variations in which the solution is discontinuous; 54. On action at a distance; 55. Elements of natural philosophy. By Sir W. Thomson and P. G. Tait. (Review); 56. On the theory of a system of electrified conductors, and other physical theories involving

  12. Conference James F.Buckli

    ScienceCinema

    None

    2011-04-25

    L'association du personnel a le plaisir d'accueillir Mons. James F.Buckli, astronaute, né en 1947. Il a participé à la mission Space Lab D1 qui pour la première fois mettait 8 personnes sur orbite.L'ass.du pers. remercie aussi Gordon White(s) de la mission américaine d'avoir permis d'organiser cette conférence

  13. A comparison of the writings of Sir William Osler and his exemplar, Sir Thomas Browne.

    PubMed Central

    Hookman, P.

    1995-01-01

    Sir William Osler was known throughout his life as a great humanitarian. His writings touched all of us, and to persons of every race, creed, and color, he showed universal feelings of justice and mercy. Osler's writing supports great tolerance for all, yet Osler's contemporaries were far less broad-minded and not free of bigotry. Osler's role model, Sir Thomas Browne, wrote openly about his marked prejudices against Catholics, Jews, Moslems, and even women. This paradox between Osler's tolerance and humanitarianism and the prejudice and bigotry of his time, as well as his role model Browne, are explored. PMID:7581308

  14. Global stability for a class of discrete SIR epidemic models.

    PubMed

    Enatsu, Yoichi; Nakata, Yukihiko; Muroya, Yoshiaki

    2010-04-01

    In this paper, we propose a class of discrete SIR epidemic models which are derived from SIR epidemic models with distributed delays by using a variation of the backward Euler method. Applying a Lyapunov functional technique, it is shown that the global dynamics of each discrete SIR epidemic model are fully determined by a single threshold parameter and the effect of discrete time delays are harmless for the global stability of the endemic equilibrium of the model. PMID:20462293

  15. Solar and Infrared Radiation Station (SIRS) Handbook

    SciTech Connect

    Stoffel, T

    2005-07-01

    The Solar Infrared Radiation Station (SIRS) provides continuous measurements of broadband shortwave (solar) and longwave (atmospheric or infrared) irradiances for downwelling and upwelling components. The following six irradiance measurements are collected from a network of stations to help determine the total radiative flux exchange within the Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) Climate Research Facility: • Direct normal shortwave (solar beam) • Diffuse horizontal shortwave (sky) • Global horizontal shortwave (total hemispheric) • Upwelling shortwave (reflected) • Downwelling longwave (atmospheric infrared) • Upwelling longwave (surface infrared)

  16. Sir John Gurdon: father of nuclear reprogramming.

    PubMed

    Blau, Helen M

    2014-07-01

    Sir John Gurdon founded the field of nuclear reprogramming. His work set the stage for the ever burgeoning area of stem cell biology and regenerative medicine. Here I provide personal reflections on times I shared with John Gurdon and professional reflections of the impact of his ground-breaking research on my own development as a scientist and on the field in general. His paradigm-shifting experiments will continue to provoke scientists to think outside the box for many years to come. PMID:24954777

  17. York, Alcuin, and Sir George Newman

    PubMed Central

    WALKER-SMITH, J

    2001-01-01

    The history of medicine can give insights into past achievements and provide knowledge and even inspiration, a valuable commodity for young students and all doctors. The contribution of Alcuin of York to basic education, and its appreciation by Sir George Newman, medical officer of health and first Chief Medical Officer of the UK in 1919, is recalled. Newman's Quaker education at Bootham School, his views on the main principles of such an education, as well as his influence on its establishment are summarised. A liberal education for doctors is important and knowledge and inspiration from the past may be one factor in enhancing morale.

 PMID:11668116

  18. President of Council-Sir Alec

    ScienceCinema

    None

    2011-04-25

    En décembre 1983 le président de l'Association du Personnel du Cern a suggéré d'inviter le président du conseil à une réunion du personnel dans le but d'améliorer la communication entre le conseil et le personnel. Le DG H.schopper remercie le président du conseil, Sir Alec, d'avoir accepté l'invitation malgré ses nombreux occupations.

  19. Sir John Gurdon: Father of nuclear reprogramming

    PubMed Central

    Blau, Helen M.

    2015-01-01

    Sir John Gurdon founded the field of nuclear reprogramming. His work set the stage for the ever burgeoning area of stem cell biology and regenerative medicine. Here I provide personal reflections on times I shared with John Gurdon and professional reflections of the impact of his ground-breaking research on my own development as a scientist and on the field in general. His paradigm-shifting experiments will continue to provoke scientists to think outside the box for many years to come. PMID:24954777

  20. Sir Kenelm Digby (1603-1665): diplomat, entrepreneur, privateer, duellist, scientist and philosopher.

    PubMed

    Mellick, Sam A

    2011-12-01

    Kenelm Digby was a man with widely differing interests. He studied at Oxford but left without a degree. At the age of 20, he was involved in a dramatic street brawl in Madrid; the following year saw him as a successful privateer in the Mediterranean and adjacent Atlantic waters, and he was then appointed a naval administrator with lucrative trade monopolies. He practised medicine without formal qualifications and gained notoriety by promoting the use of 'sympathetic' powder for healing wounds. Befriended by King James I and his son who succeeded him, he became chancellor to Queen Henrietta and was knighted by King James I on 21 October 1623 and appointed to the Privy Council. At one time, he even spent a brief time in prison, but he later became a founding member of the Royal Society and published two major philosophical treatises as well as a popular cookbook. He designed and manufactured wine bottles with tapered necks for simpler pouring and square sides for easy stacking. He dabbled in mathematics and corresponded with Fermat of 'Last Theorem' fame. In 1641, he challenged a French nobleman who publicly cast a slur on the British King to a 'digladiation' (a sword duel) and quickly dispatched him. He was a friend and admirer of Sir Thomas Browne whose 'Religio Medici' he helped to publish. The Cowlishaw Library holds a 1659 5th edition copy of this remarkable book, with Digby's name on the spine. Truly, Digby must qualify as a Renaissance man. PMID:22507419

  1. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Greenhouse, Matthew

    2008-01-01

    The James Webb Space Telescope is being developed by NASA in partnership with the European and Canadian space agencies for launch during 2013. This mission is expected to carry the legacy of discovery of the Hubble Space Telescope through the next decade, and is designed with unique capability to address key questions about formation of the first galaxies after the Big Bang, their subsequelet volution, and the formation of stars and planets within our own galaxy. This talk will present an overview of the mission science objectives and the status of the mission development.

  2. JAMES RIVER FACE WILDERNESS, VIRGINIA.

    USGS Publications Warehouse

    Brown, C. Ervin; Gazdik, Gertrude C.

    1984-01-01

    A mineral survey concluded that the James River Face Wilderness, Virginia, had little promise for the occurrence of metallic mineral resources. Two major rock units in the area do contain large nonmetallic mineral resources of quartzite and shale that have been mined for silica products and for brick and expanded aggregate, respectively. Because large deposits of the same material are more easily available in nearby areas, demand for the deposits within the wilderness is highly unlikely. No energy resources were identified in the course of this study.

  3. Seasonal dynamics in an SIR epidemic system.

    PubMed

    Augeraud-Véron, E; Sari, N

    2014-02-01

    We consider a seasonally forced SIR epidemic model where periodicity occurs in the contact rate. This periodical forcing represents successions of school terms and holidays. The epidemic dynamics are described by a switched system. Numerical studies in such a model have shown the existence of periodic solutions. First, we analytically prove the existence of an invariant domain D containing all periodic (harmonic and subharmonic) orbits. Then, using different scales in time and variables, we rewrite the SIR model as a slow-fast dynamical system and we establish the existence of a macroscopic attractor domain K, included in D, for the switched dynamics. The existence of a unique harmonic solution is also proved for any value of the magnitude of the seasonal forcing term which can be interpreted as an annual infection. Subharmonic solutions can be seen as epidemic outbreaks. Our theoretical results allow us to exhibit quantitative characteristics about epidemics, such as the maximal period between major outbreaks and maximal prevalence. PMID:23404038

  4. James Hillman (1926-2011).

    PubMed

    Stern, E Mark

    2012-09-01

    Presents an obituary for James Hillman. James Hillman, the third child of Madeline and Julian Hillman, died of metastatic bone cancer at his home in Thompson, Connecticut, on October 27, 2011. The parent of "archetypal psychology," he was born on April 12, 1926, at the Breakers, a then-opulent hotel founded by his family that overlooked the boardwalk and beach in Atlantic City, New Jersey. With an extensive footing in the classics and classical humanism, Jim established the foundations for his emerging archetypal psychology. With archetypal psychology, he was to move away from a dependence on the concept of a personal ego in favor of larger sources that relied on his notion of variegated identity. He proposed a profusion of mythical images that emerge under the rubric of "soul." Soul stands as an appellation indicating a deepening of psychic events, such as when dreams, chaos, and "pathologizing" (the struggles of imagination) are most experienced. For Hillman, psychology could not be taken as a separate discipline isolated from mythology, literature, art, philosophy, politics, religion, natural science, and the ordinary affairs of individuals. Hillman envisioned archetypes as processes that bear evidence to personal suffering and, in so doing, prompt the expansion of compassion. In 1975, Jim was nominated for a Pulitzer Prize for his book Re-Visioning Psychology (Harper & Row). In addition to many other citations, Jim had the high honor in 2001 of receiving the Medal of the Presidency of the Italian Republic. PMID:22963419

  5. Cloning, expression and characterization of Mycobacterium tuberculosis sirR.

    PubMed

    Namwat, Wises; Somnate, Baramee; Maleehual, Dutsadee; Chareonsudjai, Sorujsiri; Lulitanond, Viraphong; Faksri, Kiatichai

    2014-05-01

    Identification of new drug targets is important for the improvement of chemotherapy for tuberculosis treatment. Metal-associated gene products are candidates for novel drug development. A Mycobacterium tuberculosis (MTB) sirR-encoded protein has been proposed, but the function of MTB SirR has not yet been elucidated. Bioinformatics analysis revealed that MTB SirR contains iron binding domains with 34%-59% similarity to previously described metal-dependent gene regulators and that the gene lies in Rv2787-sirR operon. RT-PCR revealed that the Rv2787-sirR operon is transcribed a single bicistronic mRNA. Heterologous expression, purification and characterization of recombinant MTB His-tagged SirR demonstrated a 25 kDa protein (by SDS-PAGE and immunoblotting) that exists as a dimer (native PAGE). Based on electrophoretic mobility shift assay, MTB SirR bound a cis element located at -85 bp upstream of its operon. As Rv2787-sirR operon is unique only to MTB (and M. bovis), further studies on its regulation and other functions of the encoded proteins should provide leads towards the discovery of novel anti-TB drugs. PMID:24974654

  6. The Yellowstone Fires as Observed by SIR-C SAR

    NASA Technical Reports Server (NTRS)

    Rignot, Eric; Despain, Don; Holecz, Francesco

    1996-01-01

    Covers SIR-C (Spaceborne Imaging Radar C) SAR (Synthetic Aperture Radar) imaging of the 1988 Yellowstone National Forest fires. Discusses some of the images and data collected, and some conclusions drawn from them about both the fires, and SIR-C SAR imaging capabilities.

  7. Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.

    PubMed Central

    Smith, J S; Brachmann, C B; Pillus, L; Boeke, J D

    1998-01-01

    Transcriptional silencing in Saccharomyces cerevisiae occurs at the silent mating-type loci HML and HMR, at telomeres, and at the ribosomal DNA (rDNA) locus RDN1. Silencing in the rDNA occurs by a novel mechanism that depends on a single Silent Information Regulator (SIR) gene, SIR2. SIR4, essential for other silenced loci, paradoxically inhibits rDNA silencing. In this study, we elucidate a regulatory mechanism for rDNA silencing based on the finding that rDNA silencing strength directly correlates with cellular Sir2 protein levels. The endogenous level of Sir2p was shown to be limiting for rDNA silencing. Furthermore, small changes in Sir2p levels altered rDNA silencing strength. In rDNA silencing phenotypes, sir2 mutations were shown to be epistatic to sir4 mutations, indicating that SIR4 inhibition of rDNA silencing is mediated through SIR2. Furthermore, rDNA silencing is insensitive to SIR3 overexpression, but is severely reduced by overexpression of full-length Sir4p or a fragment of Sir4p that interacts with Sir2p. This negative effect of SIR4 overexpression was overridden by co-overexpression of SIR2, suggesting that SIR4 directly inhibits the rDNA silencing function of SIR2. Finally, genetic manipulations of SIR4 previously shown to promote extended life span also resulted in enhanced rDNA silencing. We propose a simple model in which telomeres act as regulators of rDNA silencing by competing for limiting amounts of Sir2 protein. PMID:9649515

  8. James Moffett's Legacy to "English Journal"

    ERIC Educational Resources Information Center

    Spalding, Elizabeth; Koshnick, Damian C.; Myers, Miles

    2012-01-01

    In this article, the authors look at James Moffett's influence on "English Journal". With the 1968 publication of his companion volumes--"Teaching the Universe of Discourse," which provided the theoretical underpinnings of his practice-oriented, and "A Student-Centered Language Arts Curriculum"--James Moffett (1929-96) became a major influence on…

  9. Pulkkinen receives James B. Macelwane Medal

    NASA Astrophysics Data System (ADS)

    Baker, Daniel N.; Pulkkinen, Tuija I.

    Tuija I. Pulkkinen was awarded the James B. Macelwane Medal at the AGU Spring Meeting Honors Ceremony, which was held on May 27, 1998, in Boston, Massachusetts. The James B. Macelwane Medal recognizes young scientists of outstanding ability who have made significant contributions to the geophysical sciences.

  10. Writing siblings: Alice James and her brothers.

    PubMed

    Hoffman, Anne Golomb

    2015-02-01

    This essay addresses the relationship of writing to embodiment, through representations of bodily sensation and fantasy in the journal of Alice James. It considers Alice James's writing in relation to her two writer brothers, William and Henry, and in light of their father's experiences of impairment and breakdown. PMID:25688678

  11. Henry James on the Art of Acting.

    ERIC Educational Resources Information Center

    Thompson, David W.

    Henry James, the nineteenth-century American novelist, also served on occasion as a theatre critic. Between 1875 and 1890 he reviewed several productions in Boston, New York, London, and Paris for "Atlantic Monthly" and other periodicals. The reviews are of interest because of James' high standards regarding acting and his often devasting comments…

  12. [Sir Francis Galton: the father of eugenics].

    PubMed

    Aubert-Marson, Dominique

    2009-01-01

    Not only was Sir Francis Galton a famous geographer and statistician, he also invented "eugenics" in 1883. Eugenics, defined as the science of improving racial stock, was developed from a new heredity theory, conceived by Galton himself, and from the evolution theory of Charles Darwin, transposed to human society by Herbert Spencer. Galton's eugenics was a program to artificially produce a better human race through regulating marriage and thus procreation. Galton put particular emphasis on "positive eugenics", aimed at encouraging the physically and mentally superior members of the population to choose partners with similar traits. In 1904, he presented his ideas in front of a vast audience of physicians and scientists in London. His widely-publicized lecture served as the starting point for the development of eugenics groups in Europe and the United States during the first half of the 20th century. PMID:19602363

  13. Sir William Ramsay and the noble gases.

    PubMed

    Davies, Alwyn G

    2012-01-01

    Sir William Ramsay was one of the world's leading scientists at the end of the 19th century, and in a spectacular period of research between 1894 and 1898, he discovered five new elements. These were the noble gases, helium, neon, argon, krypton, and xenon; they added a whole new group to the Periodic Table of the elements, and provided the keystone to our understanding of the electronic structure of atoms, and the way those electrons bind the atoms together into molecules. For this work he was awarded the Nobel Prize in Chemistry in 1904, the first such prize to come to a British subject. He was also a man of great charm, a good linguist, and a composer and performer of music, poetry and song. This review will trace his career, describe his character and give and account of the chemistry which led to the award of the Nobel Prize. PMID:22574384

  14. [Concept of SIRS and severe acute pancreatitis].

    PubMed

    Hirota, Masahiko; Sugita, Hiroki; Maeda, Keisuke; Ichibara, Atsushi; Ogawa, Michio

    2004-11-01

    Acute pancreatitis is a potentially fatal disease, the severity of which ranges from a mild edematous form to a severe necrotizing form. Most patients develop systemic inflammatory response syndrome (SIRS), which is induced by proinflammatory cytokines. The cytokine production can be induced by activation of Toll-like receptor. The breakdown products of the pancreatic and peripancreatic tissues by proteases might be the agonists. Cytokines are supposed to be produced as a biological defense system. However, cytokines may often evoke organ failure and/or immunosuppressive state, if they would be produced excessively. To express this complicated pathologic condition, Ogawa proposed a concept of LISIS(local inflammation-induced systemic immunosuppression syndrome). We have to pay attention to such aspects in the management of this disease. PMID:15552899

  15. Mirror Figuring Techniques of Sir William Herschel

    NASA Astrophysics Data System (ADS)

    Albin, E. F.

    2004-05-01

    Between the years 1773 to 1818, Sir William Herschel constructed dozens of speculum telescope mirrors, with diameters ranging from 6 - 48 inches. Very little, if any, detailed information has ever been published on the specifics of his mirror figuring efforts. The reason for this certainly relates to his desire to closely guard mirror production trade secrets. Upon Herschel's death, all telescope-making documents were passed on to his only son, Sir John Herschel. These materials are now in the possession of the British RAS and primarily consist of: a) a four volume series entitled "Experiments on the Construction of Specula," b) a 129 page treaty called "On the Construction of Specula," and c) a 179 page manuscript entitled "Results of Experiments on the Construction of Mirrors." It is suggested that publication was further delayed and then eventually abandoned due to silver-coated glass mirrors coming into favor. A recent investigation by the author, of the unpublished manuscripts on the construction of specula, suggests that Herschel's mirror figuring techniques did not involve any guess work; in fact, his methods were highly refined -- never leaving to chance the evolution of a spherical surface into the required paraboloid. At the heart of Herschel's figuring techniques were a series of aperture diaphragms (similar to the Couder masks used by modern telescope makers) that were placed over the mirror, which allowed for the precise determination of its curvature at various predefined zones. With this information, Herschel was able to vary his figuring strokes with his polishing tool accordingly. In addition, all mirrors were subsequently "star tested," sometimes with aperture diaphragms in place, allowing for field examination of the mirror's "distinctness" or performance. Double stars and the planet Saturn were favorite targets used to analyze and then correct a mirror's figure.

  16. The James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Kalirai, Jason

    2014-07-01

    The James Webb Space Telescope (JWST) will be the most powerful space telescope that we've ever constructed, and it is a critical step towards answering the top science questions outlined in both the 2000 and 2010 Astronomy & Astrophysics Decadal Surveys. In this presentation, I'll first briefly highlight the science capabilities, current status, and science timeline of JWST out to its 2018 launch. I'll then describe several frontier science opportunities that are uniquely enabled by combining JWST's high spatial resolution and unprecedented IR throughput with the Thirty Meter Telescope's spectral capabilities and visible throughput. Like Hubble and current 10 meter telescopes on the ground, the combination of these two facilities will be a great 1-2 punch to usher in a new era in UVOIR astrophysics.

  17. Doctors, disease and James Joyce.

    PubMed

    Kaplan, Robert M

    2008-08-01

    The Irish author James Joyce is regarded as the greatest modernist writer of his time. His works, notably The Dead, A Portrait of the Artist as a Young Man, Ulysses and Finnegans Wake--are intensely autobiographic including meticulous descriptions of illness and states of health--no surprise in view of Joyce's medical history and hypochondria. The Dead revolves around the tragic love of a doomed tubercular youth. Ulysses has a graphic description of Mary Joyce-s death, a funeral and a birth; Stephen Dedalus, the character based on Joyce, attends a drinking session with medical students at the lying-in hospital just as Joyce had done as a student; references to syphilis, alcoholism and other illnesses abound. PMID:18704219

  18. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2011-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes, and is currently the largest scientific project under construction in the United States. It will be a large (6.6m) cold (50K) telescope launched into orbit around the second Earth-Sun Lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. Science with the James Webb Space Telescope falls into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and black holes within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. I will conclude the talk with a description of recent technical progress in the construction of the observatory.

  19. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2011-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes, and is currently the largest scientific project under construction in the United States. It will be a large (6.6m) cold (50K) telescope launched in about 5 years into orbit around the second Earth-Sun Lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. Science with the James Webb Space Telescope falls into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and black holes within them evolved from the epoch of reionization to the present. The Birth of Stars and Proto planetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. I will conclude the talk with a description of recent technical progress in the construction of the observatory.

  20. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2011-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes, and is currently the largest scientific project under construction in the United States. It will be a large (6.6m) cold (50K) telescope launched in about 5 years into orbit around the second Earth-Sun Lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. Science with the James Webb Space Telescope falls into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and black holes within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. I will conclude the talk with a description of recent technical progress in the construction of the observatory.

  1. A Curriculum for Peace: A Conversation with Sir John Daniel.

    ERIC Educational Resources Information Center

    Perkins-Gough, Deborah; Lindfors, Sally; Ernst, Don

    2002-01-01

    Interview with Sir John Daniel, Assistant Director-General for Education of the United Nations Educational, Scientific, and Cultural Organization (UNESCO). Discusses UNESCO's role in promoting a peace curriculum in schools throughout the world. (PKP)

  2. Sir John Cornforth AC CBE FRS: his synthetic work.

    PubMed

    Purchase, Rupert; Hanson, James R

    2015-01-01

    Sir John Cornforth work on the synthesis of cholesterolandpenicillamine, on the chemistry of oxazoles, the stereochemistry of the synthesis of alkenes, the synthesis of abscisic acid and of dibenzophospholes as mimics of enzyme action, is reviewed. PMID:26601337

  3. Was Sir William Crookes epistemically virtuous?

    PubMed

    Kidd, Ian James

    2014-12-01

    The aim of this paper is to use Sir William Crookes' researches into psychical phenomena as a sustained case study of the role of epistemic virtues within scientific enquiry. Despite growing interest in virtues in science, there are few integrated historical and philosophical studies, and even fewer studies focussing on controversial or 'fringe' sciences where, one might suppose, certain epistemic virtues (like open-mindedness and tolerance) may be subjected to sterner tests. Using the virtue of epistemic courage as my focus, it emerges that Crookes' psychical researches were indeed epistemically courageous, but that this judgment must be grounded in sensitivity to the motivational complexity and context-sensitivity of the exercise of epistemic virtues. The paper then considers Crookes' remarks on the relationship between epistemic virtuousness and the intellectual integrity and public duties of scientists, thereby placing epistemic virtues in the context of wider debates about the authority of science in late modern societies. I conclude that Crookes' researches into psychical phenomena offer instructive lessons for historians of science and virtue epistemologists concerning the complexity and contextuality of epistemic virtues, and the profitable forms that future studies of virtues in science could take. PMID:25091260

  4. James Johnson on Asteroid Mission Simulation Testing

    NASA Video Gallery

    NASA Public Affairs Officer Brandi Dean talks to James Johnson, the test director for a simulated mission to an asteroid taking place at the Space Vehicle Mockup Facility at the Johnson Space Cente...

  5. The Teaching Spirit of William James

    ERIC Educational Resources Information Center

    Korn, James H.

    2003-01-01

    William James provided not only practical advice to teachers but also wisdom concerning values in living. Statements from his students show his qualities as a teacher, although some of his statements convey his ambivalence about teaching.

  6. Shuttle Imaging Radar-A (SIR-A) experiment

    NASA Technical Reports Server (NTRS)

    Elachi, C. (Editor); Cimino, J. B. (Editor)

    1982-01-01

    The SIR-A experiment was conducted in order to acquire radar data over a variety of regions to further understanding of the radar signatures of various geologic features. The capability of the Shuttle as a scientific platform for observation of the Earth's resources was assessed. The SIR-A sensor operated nominally and the full data acquisition capacity of the optical recorder was used.

  7. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2009-01-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these for science themes, JWST will be a large (6.6m) cold (50K) telescope launched to the second Earth-Sun Lagrange point early in the next decade. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA. JWST will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. I review the status and capabilities of the observatory and instruments in the context of the major scientific goals.

  8. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2012-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes. It will be a large (6.6m) cold (SDK) telescope launched into orbit around the second Earth-Sun Lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. The science goals for JWST include the formation of the first stars and galaxies in the early universe; the chemical, morphological and dynamical buildup of galaxies and the formation of stars and planetary systems. Recently, the goals have expanded to include studies of dark energy, dark matter, active galactic nuclei, exoplanets and Solar System objects. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Near-Infrared Imager and Slitless Spectrograph will cover the wavelength range 0.6 to S microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. The observatory is confirmed for launch in 2018; the design is complete and it is in its construction phase. Recent progress includes the completion of the mirrors, the delivery of the first flight instruments and the start of the integration and test phase.

  9. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Clampin, Mark

    2011-01-01

    The James Webb Space Telescope (JWST) is a large, infrared-optimized space telescope. JWST's primary science goal is to detect and characterize the first galaxies. It will also study the assembly of galaxies, star formation, and the formation of evolution of planetary systems. The observatory has a large primary mirror 6.5 meter in diameter, designed to deliver high angular resolution in the infrared, combined with a large collecting area. The telescope optics are designed and fabricated to operate at the cryogenic temperatures (,...,40 k) required for an IR optimized telescope. The primary mirror is also a segmented mirror architecture. The observatory is designed to achieve cryogenic operating temperature via passive cooling, facilitated by a five-layer sunshield which keeps the telescope in the sun's shadow. Since the observatory dimensions exceed the Ariane 5 fairing size, the observatory has to be stowed for launch and deployed following launch. The observatory will be launched into an L2 orbit that provides continuous science operations and a benign thermal environment for optical stability.

  10. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Nowak, Maria; Eichorn, William; Hill, Michael; Hylan, Jason; Marsh, James; Ohl, Raymond; Sampler, Henry; Wright, Geraldine; Crane, Allen; Herrera, Acey; Quigley, Robert; Jetten, Mark; Young, Philip

    2007-01-01

    The James Webb Space Telescope (JWST) is a 6.6m diameter, segmented, deployable telescope for cryogenic IR space astronomy (approx.40K). The JWST Observatory architecture includes the Optical Telescope Element and the Integrated Science Instrument Module (ISIM) element that contains four science instruments (SI) including a Guider. The ISIM optical metering structure is a roughly 2.2x1.7x2.2mY, asymmetric frame that is composed of carbon fiber and resin tubes bonded to invar end fittings and composite gussets and clips. The structure supports the SIs, isolates the SIs from the OTE, and supports thermal and electrical subsystems. The structure is attached to the OTE structure via strut-like kinematic mounts. The ISM structure must meet its requirements at the approx.40K cryogenic operating temperature. The SIs are aligned to the structure s coordinate system under ambient, clean room conditions using laser tracker and theodolite metrology. The ISM structure is thermally cycled for stress relief and in order to measure temperature-induced mechanical, structural changes. These ambient-to-cryogenic changes in the alignment of SI and OTE-related interfaces are an important component in the JWST Observatory alignment plan and must be verified.

  11. Hydrodynamics of internal solitons and a comparison of SIR-A and SIR-B data with ocean measurements

    NASA Technical Reports Server (NTRS)

    Apel, J. R.; Gasparovic, R. F.; Thompson, D. R.

    1986-01-01

    Large internal solitary waves have been observed by Shuttle SIR-A and SIR-B at locations in the Andaman Sea and the New York Bight. Satellite imagery and oceanographic measurements are used in conjunction with hydrodynamic interaction and electromagnetic scattering models to estimate the expected SAR image intensity modulations associated with the internal waves. There is reasonable agreement between the predicted and observed internal wave signatures.

  12. The James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2007-01-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these four science themes, JWST will be a large (6.6m) cold (50K) telescope launched to the second Earth-Sun Lagrange point early in the next decade. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA. JWST will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. In this paper, the status and capabilities of the observatory and instruments in the context of the major scientific goals are reviewed.

  13. The James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Gardner, J.

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these four science themes, JWST will be a large (6.5m) cold (50K) telescope launched to the second Earth-Sun Lagrange point early in the next decade. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA. JWST will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy between 5 and 29 microns. JWST is a facility-class mission, so most of the observing time will be allocated to investigators from the international astronomical community through competitively-selected proposals.

  14. The James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Gardner, J. P.

    2009-12-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these four science themes, JWST will be a large (6.5m) cold (50K) telescope launched to the second Earth-Sun Lagrange point early in the next decade. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA. JWST will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will operate within the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy between 5 and 29 microns. The scientific investigations described here define the measurement capabilities of the telescope, but they do not imply that those particular observations will be made. JWST is a facility-class mission, so most of the observing time will be allocated to investigators from the international astronomical community through competitively-selected proposals.

  15. St. James marine terminal facility description

    SciTech Connect

    Not Available

    1993-10-01

    The US Department of Energy (DOE) currently owns and operates a marine terminal on the west bank of the Mississippi River at St. James, Louisiana. The St. James facility was constructed by the Department to provide marine services associated with the fill and drawdown of the Strategic Petroleum Reserve (SPR) crude oil storage facilities located at Bayou Choctaw and Weeks Island, Louisiana. Although strategic to the mission of the SPR in the event of a national emergency, the St. James terminal is situated such that it has a high potential to also serve the commercial industry`s needs for crude oil terminalling and storage. The St. James terminal is located approximately 45 miles west of New Orleans and 30 miles southeast of Baton Rouge, and approximately 160 miles upstream from the mouth of the Mississippi River. Construction of the St. James terminal was initiated in 1978 and was completed in 1980. Since then, the terminal has received and transferred over 125 million barrels of crude oil to the SPR sites for storage. For crude oil distribution, the St. James terminal was connected to the neighboring LOCAP terminal by a 0.1 mile 36-inch pipeline in 1981 and to the Capline terminal by a 0.5 mile 30-inch pipeline in 1988. The terminal also has a 30-inch pipeline connection to the Koch oil terminal which was used for initial fill purposes; however, this pipeline has been disconnected and is currently inactive. A complete description of the St. James terminal facilities, operational capabilities, operational certifications, and future Government requirements are presented in Sections 2, 3, 4, and 5 respectively.

  16. Obituary: James Houck (1940 - 2015)

    NASA Astrophysics Data System (ADS)

    Weedman, Daniel; Barry, Donald; Soifer, Thomas

    James R. Houck, the leading figure in developing infrared spectroscopy for astrophysics, died in Ithaca, NY, on September 18, 2015, at age 74 from complications of Alzheimer's Disease. He was born on October 5, 1940, in Mobile, Alabama, but lived much of his early life in Pittsburgh, Pennsylvania, where he received his undergraduate degree from Carnegie Institute of Technology. Jim spent his scientific career at Cornell University. He came to Cornell as a physics graduate student in 1962 and remained until his retirement as the Kenneth A. Wallace Professor of Astronomy in 2012. His only year away from Ithaca was as a Guggenheim Fellow at Caltech, and he declined job offers from other universities because of his opinion that Ithaca provided the best environment for raising his family. His passion for learning, doing, and teaching science by building instruments and understanding physics led to great benefits for his students and astronomy colleagues. After receiving his PhD in condensed matter physics, he changed fields to work in astronomy at Cornell. He first collaborated with colleague Martin Harwit to develop a rocket program at Cornell for infrared observations and made numerous treks to the White Sands Missile Range flying payloads on Aerobee sounding rockets. Jim emphasized building spectrographs and making pioneering observations with ground based, airborne, and rocket-borne infrared instrumentation. Jim flew on every airplane NASA provided for astronomy. Those were pioneering times. One of his survival stories was of the Learjet in which both engines flamed out over the Pacific when the pilot did a celebratory barrel role after successful completion of their observations. His observations with rockets and airplanes were primarily of a variety of Galactic objects, including planetary nebulae, HII regions, and stars. But the most notable was an observation on the Convair 990 that produced a prescient discovery paper in 1973 led by Jim which discovered bound

  17. The James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Gardner, Jonathan P.; Mather, John C.; Clampin, Mark; Doyon, Rene; Greenhouse, Matthew A.; Hammel, Heidi B.; Hutchings, John B.; Jakobsen, Peter; Lilly, Simon J.; Long, Knox S.; Lunine, Jonathan I.; McCaughrean, Mark J.; Mountain, Matt; Nella, John; Rieke, George H.; Rieke, Marcia J.; Rix, Hans-Walter; Smith, Eric P.; Sonneborn, George; Stiavelli, Massimo; Stockman, H. S.; Windhorst, Rogier A.; Wright, Gillian S.

    2006-04-01

    The James Webb Space Telescope (JWST) is a large (6.6 m), cold (<50 K), infrared (IR)-optimized space observatory that will be launched early in the next decade into orbit around the second Earth Sun Lagrange point. The observatory will have four instruments: a near-IR camera, a near-IR multiobject spectrograph, and a tunable filter imager will cover the wavelength range, 0.6 < ; < 5.0 μ m, while the mid-IR instrument will do both imaging and spectroscopy from 5.0 < ; < 29 μ m. The JWST science goals are divided into four themes. The key objective of The End of the Dark Ages: First Light and Reionization theme is to identify the first luminous sources to form and to determine the ionization history of the early universe. The key objective of The Assembly of Galaxies theme is to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present day. The key objective of The Birth of Stars and Protoplanetary Systems theme is to unravel the birth and early evolution of stars, from infall on to dust-enshrouded protostars to the genesis of planetary systems. The key objective of the Planetary Systems and the Origins of Life theme is to determine the physical and chemical properties of planetary systems including our own, and investigate the potential for the origins of life in those systems. Within these themes and objectives, we have derived representative astronomical observations. To enable these observations, JWST consists of a telescope, an instrument package, a spacecraft, and a sunshield. The telescope consists of 18 beryllium segments, some of which are deployed. The segments will be brought into optical alignment on-orbit through a process of periodic wavefront sensing and control. The instrument package contains the four science instruments and a fine guidance sensor. The spacecraft provides pointing, orbit maintenance, and communications. The sunshield

  18. The James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Gardner, Jonathan P.; Mather, John C.; Clampin, Mark; Doyon, Rene; Flanagan, Kathryn A.; Franx, Marijn; Greenhouse, Matthew A.; Hammel, Heidi B.; Hutchings, John B.; Jakobsen, Peter; Lilly, Simon J.; Lunine, Jonathan I.; McCaughrean, Mark J.; Mountain, Matt; Rieke, George H.; Rieke, Marcia J.; Sonneborn, George; Stiavelli, Massimo; Windhorst, Rogier; Wright, Gillian S.

    The James Webb Space Telescope (JWST) is a large (6.6 m), cold (<50 K), infrared (IR)-optimized space observatory that will be launched early in the next decade into orbit around the second Earth-Sun Lagrange point. The observatory will have four instruments: a near-IR camera, a near-IR multi-object spectrograph, and a tunable filter imager that will cover the wavelength range, 0.6 < λ < 5.0 μm, while the mid-IR instrument will do both imaging and spectroscopy from 5.0 < λ < 29 μm. The JWST science goals are divided into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the early universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present day. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems including our own, and investigate the potential for the origins of life in those systems. To enable these science goals, JWST consists of a telescope, an instrument package, a spacecraft, and a sunshield. The telescope primary mirror is made of 18 beryllium segments, some of which are deployed. The segments will be brought into optical alignment on-orbit through a process of periodic wavefront sensing and control. The instrument package contains the four science instruments and a fine guidance sensor. The spacecraft provides pointing, orbit maintenance, and communications. The sunshield provides passive thermal control. The JWST operations plan is based on that used for previous space observatories, and the majority of JWST

  19. William james, gustav fechner, and early psychophysics.

    PubMed

    Hawkins, Stephanie L

    2011-01-01

    American psychologist and philosopher William James devoted the entirety of his career to exploring the nature of volition, as expressed by such phenomena as will, attention, and belief. As part of that endeavor, James's unorthodox scientific pursuits, from his experiments with nitrous oxide and hallucinogenic drugs to his investigation of spiritualist mediums, represent his attempt to address the "hard problems" of consciousness for which his training in brain physiology and experimental psychology could not entirely account. As a student, James's reading in chemistry and physics had sparked his interest in the concepts of energy and force, terms that he later deployed in his writing about consciousness and in his arguments against philosophical monism and scientific materialism, as he developed his "radically empiricist" ideas privileging discontinuity and plurality. Despite James's long campaign against scientific materialism, he was, however, convinced of the existence of a naturalistic explanation for the more "wayward and fitful" aspects of mind, including transcendent experiences associated with hysteria, genius, and religious ecstasy. In this paper, I examine aspects of James's thought that are still important for contemporary debates in psychology and neuroscience: his "transmission theory" of consciousness, his ideas on the "knowing of things together," and, finally, the related concept of "the compounding of consciousness," which postulates the theoretical possibility for individual entities within a conscious system of thought to "know" the thoughts of others within the system. Taken together, these ideas suggest that James, in spite of, or perhaps because of, his forays into metaphysics, was working toward a naturalistic understanding of consciousness, what I will term a "distributive model," based on his understanding of consciousness as an "awareness" that interacts dynamically within, and in relation to, its environment. PMID:22016738

  20. A concert of music by Sir William Herschel

    NASA Astrophysics Data System (ADS)

    Hessman, F. V.; Hammer, C.

    2002-01-01

    The Orchester Göttinger Musikfreunde presented an evening of music in the magnificent Aula of the University as one of the social events of the conference. The astronomical highlights of the concert were two symphonic works by Sir William Herschel, including an oboe solo by a member of the LOC (W. Glatzel). This is the text from the concert programme. A recording of the concert is included in this proceedings. Programme --------- Sir William Herschel (1738-1822): Symphony No. 13 in D Major (1762) W. A. Mozart (1756-1791): Piano Concerto No. 27 in B Major (KV 595), C. Hammer (piano) Sir William Herschel (1738-1822): Fragment of an Oboe Concerto in C Major (MS790), W. Glatzel (oboe) J. Haydn (1732-1809): Symphony No. 91 E-flat Major We would like to acknowledge the Sparkasse Göttingen and the Versicherungsgesellschaft Hannover for generously making this concert possible.

  1. The Shuttle Imaging Radar B (SIR-B) experiment report

    NASA Technical Reports Server (NTRS)

    Cimino, Jo Bea; Holt, Benjamin; Richardson, Annie

    1988-01-01

    The primary objective of the SIR-B experiment was to acquire multiple-incidence-angle radar imagery of a variety of Earth's surfaces to better understand the effects of imaging geometry on radar backscatter. A complementary objective was to map extensive regions of particular interest. Under these broad objectives, many specific scientific experiments were defined by the 43 SIR-B Science Team members, including studies in the area of geology, vegetation, radar penetration, oceanography, image analysis, and calibration technique development. Approximately 20 percent of the planned digital data were collected, meeting 40 percent of the scientific objectives. This report is an overview of the SIR-B experiment and includes the science investigations, hardware design, mission scenario, mission operations, events of the actual missions, astronaut participation, data products (including auxiliary data), calibrations, and a summary of the actual coverage. Also included are several image samples.

  2. Plasma biomarkers of SIRS and MODS associated with canine babesiosis.

    PubMed

    Kuleš, J; de Torre-Minguela, C; Barić Rafaj, R; Gotić, J; Nižić, P; Ceron, J J; Mrljak, V

    2016-04-01

    Canine babesiosis is a tick-borne disease caused by the haemoprotozoan parasites of the genus Babesia. Early detection of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) is of major importance in clinical practice for providing information about severity and outcomes of the disease and therapy. Plasma samples were taken at admission from five dogs with uncomplicated babesiosis caused by B. canis canis, five dogs with babesiosis and SIRS, five dogs with babesiosis and MODS, and five healthy dogs. After two-dimensional electrophoresis and capillary reversed - phase liquid chromatography coupled online with tandem mass spectrometry, 68 differentially expressed spots with level of significance P<0.05 were detected between groups. SIRS in babesiosis was characterised by increases in paraoxonase 1 and apoA-I, whereas MODS with decrease of complement inhibitors leading to prolonged complement activation and decrease of vitamin D binding protein due to haemolysis and activation of the coagulation cascade. PMID:27033937

  3. Obituary: James Houck (1940 - 2015)

    NASA Astrophysics Data System (ADS)

    Weedman, Daniel; Barry, Donald; Soifer, Thomas

    James R. Houck, the leading figure in developing infrared spectroscopy for astrophysics, died in Ithaca, NY, on September 18, 2015, at age 74 from complications of Alzheimer's Disease. He was born on October 5, 1940, in Mobile, Alabama, but lived much of his early life in Pittsburgh, Pennsylvania, where he received his undergraduate degree from Carnegie Institute of Technology. Jim spent his scientific career at Cornell University. He came to Cornell as a physics graduate student in 1962 and remained until his retirement as the Kenneth A. Wallace Professor of Astronomy in 2012. His only year away from Ithaca was as a Guggenheim Fellow at Caltech, and he declined job offers from other universities because of his opinion that Ithaca provided the best environment for raising his family. His passion for learning, doing, and teaching science by building instruments and understanding physics led to great benefits for his students and astronomy colleagues. After receiving his PhD in condensed matter physics, he changed fields to work in astronomy at Cornell. He first collaborated with colleague Martin Harwit to develop a rocket program at Cornell for infrared observations and made numerous treks to the White Sands Missile Range flying payloads on Aerobee sounding rockets. Jim emphasized building spectrographs and making pioneering observations with ground based, airborne, and rocket-borne infrared instrumentation. Jim flew on every airplane NASA provided for astronomy. Those were pioneering times. One of his survival stories was of the Learjet in which both engines flamed out over the Pacific when the pilot did a celebratory barrel role after successful completion of their observations. His observations with rockets and airplanes were primarily of a variety of Galactic objects, including planetary nebulae, HII regions, and stars. But the most notable was an observation on the Convair 990 that produced a prescient discovery paper in 1973 led by Jim which discovered bound

  4. Performance of the SIR-B digital image processing subsystem

    NASA Technical Reports Server (NTRS)

    Curlander, J. C.

    1986-01-01

    A ground-based system to generate digital SAR image products has been developed and implemented in support of the SIR-B mission. This system is designed to achieve the maximum throughput while meeting strict image fidelity criteria. Its capabilities include: automated radiometric and geometric correction of the output imagery; high-precision absolute location without tiepoint registration; filtering of the raw data to remove spurious signals from alien radars; and automated catologing to maintain a full set of radar and image production facility in support of the SIR-B science investigators routinely produces over 80 image frames per week.

  5. SIR-2 Data Normalization and Integration with M3 Data

    NASA Astrophysics Data System (ADS)

    Grumpe, A.; Felder, M. P.; Wöhler, C.; Mall, U.

    2013-09-01

    The point spectrometer SIR-2 on Chandrayaan-1 provided radiance spectra integrated over circular footprints of 200 m diameter in the wavelength range 934-2410.8 nm in 256 channels [1]. To analyze SIR-2 reflectance spectra in their spatial context, a coregistration to Chandrayaan-1 M³ hyperspectral images [2] as well as a correction for topography and thermal emission are inevitable. The thermal and topographic correction procedure is based on the surface temperature and a digital elevation model (DEM) inferred from M³ data. The corrected reflectance spectra are then normalized to a standard illumination and viewing geometry.

  6. William James, Philosophical Father of Experience-Based Education.

    ERIC Educational Resources Information Center

    Donaldson, George W.; Vinson, Richard

    1979-01-01

    The article briefly describes the life of William James, nineteenth-century philosopher and psychologist, noting the development of his pragmatist philosophy. The article uses James' work and ideas to support 11 principles of contemporary experience-based education. (SB)

  7. Speculation on Curriculum from the Perspective of William James.

    ERIC Educational Resources Information Center

    Shubert, William H; Zissis, Georgiana

    1988-01-01

    This article discusses the implications for curriculum theory, research, and practice of William James' thought. Also considered is the question of what curriculum theory and research might be like if James had garnered greater influence than Thorndike. (IAH)

  8. 76 FR 12295 - James Luehman; Denial of Petition for Rulemaking

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... REGULATORY COMMISSION 10 CFR Part 50 James Luehman; Denial of Petition for Rulemaking AGENCY: Nuclear... Commission (NRC or the Commission) is denying a petition for rulemaking (PRM) submitted by James Luehman...

  9. A Cross-Institutional Factor Structure Replication of the Michigan State University Sirs Faculty Evaluation Model

    ERIC Educational Resources Information Center

    Arreola, Raoul A.

    1973-01-01

    Determines that the factor structure of the instructional model measured by the Michigan State University Student Instructional Rating System (SIRS) form could be replicated by an adapted version of the SIRS instrument at Florida State University. (Author)

  10. James Bernard Russell: Scholar, collaborator, mentor

    Technology Transfer Automated Retrieval System (TEKTRAN)

    At the time of his untimely death in 2009, ARS scientist Dr. James B. Russell had established himself as the premier rumen microbiologist of his generation. Dr. Russell’s many contributions to the field, including much of the early work on the Cornell Net Carbohydrate System model, were the product ...

  11. The James Bay Project: Reaction or Action?

    ERIC Educational Resources Information Center

    Mackwood, Gae

    1991-01-01

    Discusses the plan to restructure northern Quebec's landscape through the James Bay hydroelectric project. Suggests that the project offers opportunities to study development versus preservation, federal versus provincial powers, and the conflict between business and Native communities. Explores the need to teach students to care about social…

  12. Milestone reached for James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Banks, Michael

    2016-03-01

    The primary mirror for the James Webb Space Telescope (JWST) - the successor to the Hubble Space Telescope - is complete after engineers at NASA's Goddard Space Flight Center in Maryland, US, put in place the craft's 18th and final mirror segment.

  13. Astronaut James Buchli wearing extravehicular mobility unit

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Astronaut James F. Buchli, wearing an extravehicular mobility unit (EMU), is about to be submerged in the weightless environment training facility (WETF) to simulate a contingency extravehicular activity (EVA) for STS 61-A. In this portrait view, Buchli is wearing a communications carrier assembly (CCA).

  14. James Joyce: steps towards a diagnosis.

    PubMed

    Lyons, J B

    2000-12-01

    Authors whose scholarship is in the golden realm of English literature have not hesitated to make pronouncements on James Joyce's health. A publication in this genre claims he had tabes dorsalis. One feels that an authoritative comment, accepting or rejecting a diagnosis of neurosyphilis, should be provided by the Journal of the History of the Neurosciences. PMID:11232371

  15. The Religion Journalism of James Gordon Bennett.

    ERIC Educational Resources Information Center

    Buddenbaum, Judith M.

    A study was conducted to examine the journalism work of James Gordon Bennett, who founded the "New York Herald" in the 1830s, and to determine the nature of his coverage of religion before, during, and after the "Moral War" waged in 1840 against Bennett's popular newspaper. In addition, the study analyzed what Bennett's religion coverage reveals…

  16. James Madison and the Constitutional Convention.

    ERIC Educational Resources Information Center

    Scanlon, Thomas M.

    1987-01-01

    Part 1 of this three-part article traces James Madison's life and focuses primarily on those events that prepared him for leadership in the U.S. Constitutional Convention of 1787. It describes his early love of learning, education, and public service efforts. Part 2 chronicles Madison's devotion to study and preparation prior to the Constitutional…

  17. William James Sidis, The Broken Twig

    ERIC Educational Resources Information Center

    Montour, Kathleen

    1977-01-01

    By presenting cases of prodigies who entered college as early as William James Bidis but who succeeded, this paper attempts to dissuade the public from its opposition to educational acceleration for precocious children, to which the "Sidis fallacy" has helped give rise. (Author)

  18. Low carbon dialysis for James Paget.

    PubMed

    2010-09-01

    ELGA Process Water explains how it provided a new water purification system for the renal dialysis unit at the James Paget University Hospital in Great Yarmouth that not only delivers the required water quality, and meets Renal Association guidelines on water treatment plants, but will also help reduce the acute healthcare facility's carbon footprint. PMID:20882912

  19. A Reflective Conversation with James H. Borland

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Moore, Tammy-Lynne; Borland, James H.

    2014-01-01

    James H. Borland, Ph.D. is Professor of Education in the Department of Curriculum and Teaching at Teachers College, Columbia University in New York City. In this reflective conversation, he reflects on his experiences in an urban environment and the current challenges in gifted education. He argues for ongoing diagnosis of learners' needs…

  20. 7. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. John and James Dobson Carpet Mill, East and West Parcels, May 17, 1926, (John and James Dobson, Inc. East Falls, Aero Service Corp., Neg. No. 5986, May 17, 1926, Free Library of Philadelphia, Print Collection). - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  1. 77 FR 25592 - Drawbridge Operation Regulations; James River, Hopewell, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; James River, Hopewell, VA AGENCY... Memorial Bridge, at mile 65.0, across the James River, at Hopewell, VA. This deviation is necessary to... schedule, the SR 156/Benjamin Harrison Memorial Bridge, at mile 65.0, across the James River, at...

  2. The Darwinian Center to the Vision of William James.

    ERIC Educational Resources Information Center

    Bredo, Eric

    The essence of William James's vision can sometimes be hard to discover due to emotional volatility and exploratory impulsiveness. On the other hand, beneath James's apparent inconsistency was a constancy of purpose that can be easily underestimated. This paper argues that the center of James's vision lay in an interpretation of Darwinism. By…

  3. Ready Reference Tools: EBSCO Topic Search and SIRS Researcher.

    ERIC Educational Resources Information Center

    Goins, Sharon; Dayment, Lu

    1998-01-01

    Discussion of ready reference and current events collections in high school libraries focuses on a comparison of two CD-ROM services, EBSCO Topic Search and the SIRS Researcher. Considers licensing; access; search strategies; viewing articles; currency; printing; added value features; and advantages of CD-ROMs. (LRW)

  4. Sir William Johnson and the Indians of New York.

    ERIC Educational Resources Information Center

    Hamilton, Milton W.

    In order to make the vast literature about the history of Indian and white relations in New York readily accessible to teachers, students, and general readers, this booklet brings together the main points of the relationship between the Indians and Sir William Johnson. Johnson is a key figure in the Indian story of New York state during the 1770s.…

  5. On the Shoulders of Sir Isaac Newton and Arthur Storer

    ERIC Educational Resources Information Center

    Martin, Helen E.; Evans-Gondo, Bonita

    2013-01-01

    Helen E. Martin, the author of this article, is a retired National Board Certified Teacher who has been researching Sir Isaac Newton's unpublished manuscripts for over three decades. While researching the work of Newton, a teacher she was mentoring asked for some hands-on activities to study planetary motion. The description of the activity…

  6. Why Creativity Now? A Conversation with Sir Ken Robinson

    ERIC Educational Resources Information Center

    Azzam, Amy M.

    2009-01-01

    In this interview, creativity expert Sir Ken Robinson makes the case for creativity as the crucial 21st-century skill. Genuine creative processes involve critical thinking as well as imaginative insights and fresh ideas. Also, creativity is a process, not a single event, one that requires continual evaluation. It's about everyone, it's a function…

  7. Neuro syphilis: Portrayals by Sir Arthur Conan Doyle

    PubMed Central

    Somasundaram, O.

    2009-01-01

    The developments in neuro syphilis in the 19th century are integral parts of the history of psychiatry. The delineation of various aspects of neuro syphilis by Sir Arthur Conan Doyle in three of his stories is discussed in brief. PMID:19881059

  8. Reflection on the "New Dynamics" of Distance Education: An Interview with Sir John Daniel

    ERIC Educational Resources Information Center

    Latchem, Colin

    2012-01-01

    This article presents an interview with Sir John Daniel outgoing President and CEO of the Commonwealth of Learning. Sir John Daniel's term as President and Chief Executive Officer of the Commonwealth of Learning (COL) ended on May 31, 2012. Readers of "Distance Education" will know of Sir John's work at the Tele-universite (Directeur des Etudes,…

  9. 33 CFR 147.817 - Sir Douglas Morpeth Tension Leg Platform safety zone.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Sir Douglas Morpeth Tension Leg... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.817 Sir Douglas Morpeth Tension Leg Platform safety zone. (a) Description. The Sir Douglas Morpeth Tension Leg Platform...

  10. The Student Instructional Report for Distance Education: e-SIR II

    ERIC Educational Resources Information Center

    Pike, Gary R.

    2004-01-01

    Recently the Educational Testing Service (ETS) has modified its Student Instructional Report II (SIR II) for use in online distance education courses. The SIR II is a second-generation survey based on more than thirty years of experience with student evaluations (Centra, 1998; Centra and Gaubatz, n.d.). The e-SIR II is based on the highly…

  11. God, James Watt, and the public's land

    SciTech Connect

    Wolf, R.

    1981-05-01

    The political career of James Watt, Secretary of the Interior, is chronicled. His current reputation as archenemy of the environmental movement is largely the outgrowth of three and a half years of activity on behalf of the Mountain States Legal Foundation. Since taking office in January 1981, Watt has moved swiftly to impose his individual standards on USDI. Various programs and agencies are being terminated, and public lands may soon be open for mineral and energy exploitation. (7 drawings, 1 photo)

  12. Stability analysis of the Euler discretization for SIR epidemic model

    SciTech Connect

    Suryanto, Agus

    2014-06-19

    In this paper we consider a discrete SIR epidemic model obtained by the Euler method. For that discrete model, existence of disease free equilibrium and endemic equilibrium is established. Sufficient conditions on the local asymptotical stability of both disease free equilibrium and endemic equilibrium are also derived. It is found that the local asymptotical stability of the existing equilibrium is achieved only for a small time step size h. If h is further increased and passes the critical value, then both equilibriums will lose their stability. Our numerical simulations show that a complex dynamical behavior such as bifurcation or chaos phenomenon will appear for relatively large h. Both analytical and numerical results show that the discrete SIR model has a richer dynamical behavior than its continuous counterpart.

  13. Nuclear export modulates the cytoplasmic Sir2 homologue Hst2

    PubMed Central

    Wilson, Jeanne M; Le, Viet Q; Zimmerman, Collin; Marmorstein, Ronen; Pillus, Lorraine

    2006-01-01

    Modulating transcription factors is crucial to executing sophisticated gene expression programs. The silent information regulator 2 (Sir2) family of NAD-dependent protein deacetylases influences transcription by targeting proteins such as histones, p53 and forkhead-box family transcription factors. Although apparently cytoplasmic, both mammalian SIRT2 and its yeast orthologue Hst2 have been implicated in transcriptional regulation. Here, we show that Hst2 moves between the nucleus and cytoplasm, but is largely cytoplasmic owing to efficient nuclear export. This nuclear exclusion is mediated by the exportin chromosomal region maintenance 1 (Crm1) and a putative leucine-rich nuclear export sequence in Hst2, which overlaps a unique autoregulatory helix. Disruption of Hst2 export shows that nuclear exclusion inhibits the activity of Hst2 as a transcriptional repressor. Our identification of putative nuclear export sequences in numerous vertebrate SIRT2 proteins shows that active nuclear export can be a conserved mechanism for regulating Sir2 homologues. PMID:17110954

  14. Diversity in the Sir2 family of protein deacetylases.

    PubMed

    Buck, Stephen W; Gallo, Christopher M; Smith, Jeffrey S

    2004-06-01

    The silent information regulator (Sir2) family of protein deacetylases (Sirtuins) are nicotinamide adenine dinucleotide (NAD)(+)-dependent enzymes that hydrolyze one molecule of NAD(+) for every lysine residue that is deacetylated. The Sirtuins are phylogenetically conserved in eukaryotes, prokaryotes, and Archeal species. Prokaryotic and Archeal species usually have one or two Sirtuin homologs, whereas eukaryotes typically have multiple versions. The founding member of this protein family is the Sir2 histone deacetylase of Saccharomyces cerevisiae, which is absolutely required for transcriptional silencing in this organism. Sirtuins in other organisms often have nonhistone substrates and in eukaryotes, are not always localized in the nucleus. The diversity of substrates is reflected in the various biological activities that Sirtuins function, including development, metabolism, apoptosis, and heterochromatin formation. This review emphasizes the great diversity in Sirtuin function and highlights its unusual catalytic properties. PMID:14742637

  15. Digital simulation of the SIR-C sensor electronics

    NASA Technical Reports Server (NTRS)

    Klein, Jeffrey D.; Curlander, John C.

    1987-01-01

    In this paper software for simulation of the response of the SIR-C sensor to a point target is described. Synthetic SAR data is generated by passing successive chirps through a simulation of the transmitter electronics, propagation path and receiver electronics. This result is then processed with a digital correlator to yield the point target response of the system. This allows an accurate assessment of the effect of the radar design on the final image product.

  16. Hero or villain?--Sir Richard Doll and occupational cancer.

    PubMed

    Tweedale, Geoffrey

    2007-01-01

    In 2006, the English media broke the story that Sir Richard Doll had for many years been retained on a secret consultancy by Monsanto. Doll's colleagues rushed to his defense, arguing that the story was an unjustified smear on a great man whose work had saved millions of lives. However, Doll's conflicts of interest in his occupational health epidemiology are shown to sit uneasily alongside his more independent smoking/lung cancer studies. PMID:17718181

  17. Sarcophilia, cremation and Sir Henry Thompson (1820-1904).

    PubMed

    Jellinek, E H

    2009-11-01

    Sarcophilia, a neologism for an attachment to human remains, is set in a review of the history of the disposal of the dead. The ancient practice of cremation was relaunched late in the 19th century by the urological surgeon cum social reformer Sir Henry Thompson. He was stimulated by Edwin Chadwick and Charles Dickens, and by Charles Darwin's observations on the earthworm. Sarcophilia is the reason for the controversial Human Tissue Act of 2004. PMID:20029076

  18. A SIRS epidemic model with infection-age dependence

    NASA Astrophysics Data System (ADS)

    Zhang, Zhonghua; Peng, Jigen

    2007-07-01

    Based on J. Mena-Lorca and H.W. Hethcote's epidemic model, a SIRS epidemic model with infection-age-dependent infectivity and general nonlinear contact rate is formulated. Under general conditions, the unique existence of its global positive solutions is obtained. Moreover, under more general assumptions than the existing, the existence and asymptotical stability of its equilibria are discussed. In the end, the condition on the stability of endemic equilibrium is verified by a special model.

  19. James Sowerby: meteorites and his meteoritic sword made for the Emperor of Russia, Alexander I, in 1814

    PubMed Central

    Henderson, Paul

    2013-01-01

    James Sowerby included meteorites in his publications of British and exotic natural history and so raised interest in their nature and origins at a time of much debate and involving the President of the Royal Society, Sir Joseph Banks. The celebrations over the defeat of France in 1814 prompted Sowerby to make a sword from the Cape of Good Hope iron meteorite to present to the Russian Emperor, Alexander I, at the time of his state visit to London in June 1814 and in recognition of his achievements in bringing peace to Europe. The story of its attempted presentation, its final reception and the following response, including publications, all helped to increase interest in meteorites and their properties. The rediscovery of the sword after a lengthy disappearance probably brings an unusual saga to a fitting close.

  20. SIR: Deterministic protein inference from peptides assigned to MS data.

    PubMed

    Matthiesen, Rune; Prieto, Gorka; Amorim, Antonio; Aloria, Kerman; Fullaondo, Asier; Carvalho, Ana S; Arizmendi, Jesus M

    2012-07-16

    Currently the bottom up approach is the most popular for characterizing protein samples by mass spectrometry. This is mainly attributed to the fact that the bottom up approach has been successfully optimized for high throughput studies. However, the bottom up approach is associated with a number of challenges such as loss of linkage information between peptides. Previous publications have addressed some of these problems which are commonly referred to as protein inference. Nevertheless, all previous publications on the subject are oversimplified and do not represent the full complexity of the proteins identified. To this end we present here SIR (spectra based isoform resolver) that uses a novel transparent and systematic approach for organizing and presenting identified proteins based on peptide spectra assignments. The algorithm groups peptides and proteins into five evidence groups and calculates sixteen parameters for each identified protein that are useful for cases where deterministic protein inference is the goal. The novel approach has been incorporated into SIR which is a user-friendly tool only concerned with protein inference based on imports of Mascot search results. SIR has in addition two visualization tools that facilitate further exploration of the protein inference problem. PMID:22626983

  1. SIR model with general distribution function in the infectious period

    NASA Astrophysics Data System (ADS)

    Gomes, Marcelo F. C.; Gonçalves, Sebastián

    2009-08-01

    The Susceptible-Infected-Removed or SIR model, as it was formulated by Kermack and McKendrick, is the key model for epidemic dynamics. Most applications of such a basic scheme use a constant rate for the removal term. However, that assumption corresponds to the rather unrealistic exponential distribution of infectious times. On the other hand, recent approaches, like numerical simulations, frequently assume a fixed and uniform duration for the infectious state-which is unrealistic too. The extreme assumptions in those different schemes are a hurdle that can frustrate any intention of drawing comparison between results from them. In the present contribution we study the delay equations for the SIR model, comparing the solutions for many typical cases with the simulation counterpart and with the standard SIR model. Using delay equations, where each infected individual is removed at a specific time after being infected, the dynamics for the infected and susceptible agree almost exactly with the numerical implementation. Even in the general case of distributed infective periods, the agreement is excellent.

  2. Development of SIR-C Ground Calibration Equipment

    NASA Technical Reports Server (NTRS)

    Freeman, A.; Azeem, M.; Haub, D.; Sarabandi, K.

    1993-01-01

    SIR-C/X-SAR is currently scheduled for launch in April 1994. SIR-C is an L-Band and C-Band, multi-polarization spaceborne SAR system developed by NASA/JPL. X- SAR is an X-Band SAR system developed by DARA/ASI. One of the problems involved in calibrating the SIR-C instrument is to make sure that the horizontal (H) and vertical (V) polarized beams are aligned in the azimuth direction, i.e.. that they are pointing in the same direction. This is important if the polarimetric performance specifications for the system are to be met. To solve this problem, we have designed and built a prototype of a low-cost ground receiver capable of recording received power from two antennas, one H-polarized, the other V-polarized. The two signals are mixed to audio then recorded on the left and right stereo channels of a standard audio cassette player. The audio cassette recording can then be played back directly into a Macintosh computer, where it is digitized. Analysis of.

  3. A Fractional Order Recovery SIR Model from a Stochastic Process.

    PubMed

    Angstmann, C N; Henry, B I; McGann, A V

    2016-03-01

    Over the past several decades, there has been a proliferation of epidemiological models with ordinary derivatives replaced by fractional derivatives in an ad hoc manner. These models may be mathematically interesting, but their relevance is uncertain. Here we develop an SIR model for an epidemic, including vital dynamics, from an underlying stochastic process. We show how fractional differential operators arise naturally in these models whenever the recovery time from the disease is power-law distributed. This can provide a model for a chronic disease process where individuals who are infected for a long time are unlikely to recover. The fractional order recovery model is shown to be consistent with the Kermack-McKendrick age-structured SIR model, and it reduces to the Hethcote-Tudor integral equation SIR model. The derivation from a stochastic process is extended to discrete time, providing a stable numerical method for solving the model equations. We have carried out simulations of the fractional order recovery model showing convergence to equilibrium states. The number of infecteds in the endemic equilibrium state increases as the fractional order of the derivative tends to zero. PMID:26940822

  4. 10. Historic American Buildings Survey James R. Dunlop, Inc., Photographer, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey James R. Dunlop, Inc., Photographer, n.d. STABLES, INTERIOR DEMOLISHED - Larz Anderson House, 2118 Massachusetts Avenue Northwest, Washington, District of Columbia, DC

  5. 3. Historic American Buildings Survey James R. Dunlop, Inc., Photographer, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey James R. Dunlop, Inc., Photographer, n.d. ARCHWAY TOWARD ENTRANCE - Larz Anderson House, 2118 Massachusetts Avenue Northwest, Washington, District of Columbia, DC

  6. [Nicolas Dobo and Pierre Jame about the army medical general Lucian Jame].

    PubMed

    Dobo, N; Jame, P

    1996-01-01

    Lucien Jame was born October the 20th 1891 at Gourdon (Lot). State Police Officer's son, he studied in Lyon at the Military Health School. Called up August the 6th 1914, he shined among many fights and wore a lot of medals. After the armistice he defended his thesis upon "Venereal diseases prophylaxis study". March the 9th 1921, medical Officer in South Algeria, he published some original articles regarding to leprosis, tuberculosis and malaria. After a competitive examination in France, Lucien Jame became a Medical Commanding Officer of Military Health Service in Toulouse where Nicolas Dobo was at his disposal. August the 6th 1943, in the same rank in Algier then in Rabat, Lucien Jame reached the top of his career as Chief Executive of Military Health Service. He planed First French army medical operations through Italy, France and Germany battles. "Grand-Officier de la Légion d'honneur", the Army Medical General Lucien Jame retired but kept on with works dedicated to hygiene and preventive medicine till he died, June the 16th, 1969. PMID:11624989

  7. The lymphocyte in immunology: from James B. Murphy to James L. Gowans.

    PubMed

    Silverstein, A M

    2001-07-01

    Between 1912 and 1921, James Murphy established conclusively the role of the lymphocyte in tissue and tumor graft rejection and in protection against infection. Contemporary mainstream immunology paid little attention to these findings, until the lymphocyte was "rediscovered" with the advent of modern cellular immunology after the mid-1950s. PMID:11429534

  8. Phylogenetic conservation and homology modeling help reveal a novel domain within the budding yeast heterochromatin protein Sir1.

    PubMed

    Hou, Zhonggang; Danzer, John R; Mendoza, Liza; Bose, Melissa E; Müller, Ulrika; Williams, Barry; Fox, Catherine A

    2009-02-01

    The yeast Sir1 protein's ability to bind and silence the cryptic mating-type locus HMRa requires a protein-protein interaction between Sir1 and the origin recognition complex (ORC). A domain within the C-terminal half of Sir1, the Sir1 ORC interaction region (Sir1OIR), and the conserved bromo-adjacent homology (BAH) domain within Orc1, the largest subunit of ORC, mediate this interaction. The structure of the Sir1OIR-Orc1BAH complex is known. Sir1OIR and Orc1BAH interacted with a high affinity in vitro, but the Sir1OIR did not inhibit Sir1-dependent silencing when overproduced in vivo, suggesting that other regions of Sir1 helped it bind HMRa. Comparisons of diverged Sir1 proteins revealed two highly conserved regions, N1 and N2, within Sir1's poorly characterized N-terminal half. An N-terminal portion of Sir1 (residues 27 to 149 [Sir1(27-149)]) is similar in sequence to the Sir1OIR; homology modeling predicted a structure for Sir1(27-149) in which N1 formed a submodule similar to the known Orc1BAH-interacting surface on Sir1. Consistent with these findings, two-hybrid assays indicated that the Sir1 N terminus could interact with BAH domains. Amino acid substitutions within or near N1 or N2 reduced full-length Sir1's ability to bind and silence HMRa and to interact with Orc1BAH in a two-hybrid assay. Purified recombinant Sir1 formed a large protease-resistant structure within which the Sir1OIR domain was protected, and Orc1BAH bound Sir1OIR more efficiently than full-length Sir1 in vitro. Thus, the Sir1 N terminus exhibited both positive and negative roles in the formation of a Sir1-ORC silencing complex. This functional duality might contribute to Sir1's selectivity for silencer-bound ORCs in vivo. PMID:19029247

  9. Remote sensing of rice fields and sea pollution by SIR-B

    NASA Technical Reports Server (NTRS)

    Fugono, N.; Furuhama, Y.; Takasugi, T.; Okamoto, K.; Fujita, M.; Yoshikado, S.; Masuko, H.; Shinozuka, T.; Inomata, H.; Shiro, I.

    1984-01-01

    Sensor calibration, rice fields, and sea pollution are to be investigated with respect to shuttle imaging radar-B (SIR-B). It is planned that the resolution characteristics of the SIR-B be evaluated, the sidelobe characteristics of the SIR-B be investigated, and the relationship between backscatter cross section and image intensity be established. The microwave-scattering characteristics of rice fields are to be studied using SIR-B data. The possibility of classifying crops from SIR-B data is to be explored. The characteristics of the radar image of oil-like surface films under several sea surface conditions are to be determined. The absolute measurement capability of the sea surface scattering cross section is to be estimated using the SIR.

  10. Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.

    PubMed

    Gallagher, Jennifer E G; Babiarz, Joshua E; Teytelman, Leonid; Wolfe, Kenneth H; Rine, Jasper

    2009-04-01

    Heterochromatin renders domains of chromosomes transcriptionally silent and, due to clonal variation in its formation, can generate heritably distinct populations of genetically identical cells. Saccharomyces cerevisiae's Sir1 functions primarily in the establishment, but not the maintenance, of heterochromatic silencing at the HMR and HML loci. In several Saccharomyces species, we discovered multiple paralogs of Sir1, called Kos1-Kos4 (Kin of Sir1). The Kos and Sir1 proteins contributed partially overlapping functions to silencing of both cryptic mating loci in S. bayanus. Mutants of these paralogs reduced silencing at HML more than at HMR. Most genes of the SIR1 family were located near telomeres, and at least one paralog was regulated by telomere position effect. In S. cerevisiae, Sir1 is recruited to the silencers at HML and HMR via its ORC interacting region (OIR), which binds the bromo adjacent homology (BAH) domain of Orc1. Zygosaccharomyces rouxii, which diverged from Saccharomyces after the appearance of the silent mating cassettes, but before the whole-genome duplication, contained an ortholog of Kos3 that was apparently the archetypal member of the family, with only one OIR. In contrast, a duplication of this domain was present in all orthologs of Sir1, Kos1, Kos2, and Kos4. We propose that the functional specialization of Sir3, itself a paralog of Orc1, as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions. PMID:19171939

  11. James R. Wait (1924-1998)

    NASA Astrophysics Data System (ADS)

    Hill, David A.

    James (Jim) R.Wait, a pioneer in electromagnetic theory and applications to geophysical exploration, died of cancer in Tucson, Arizona, on October 1, 1998. At 74, he was still very active and innovative in electromagnetics as Regents Professor Emeritus, University of Arizona, and as a consultant in electrical geophysics. He is survived by his wife, Gertrude; his son, George; his daughter, Laura; and three grandchildren, James, Carolyn, and Connor.Jim was born in Ottawa, Ontario, Canada, on January 23, 1924. He obtained B.A.Sc.and M.A.Sc. degrees in 1948 and 1949, respectively and his Ph.D. degree in 1951, in electrical engineering, all from the University of Toronto. He obtained his “T” in skiing and remained an avid skier all his life. Jim stayed in great shape and always found time to work out despite his busy schedule. I still remember the business trip where Jim and I ran laps around the parking lot of a Holiday Inn for his daily workout.

  12. Selective management of cardiovascular dysfunction in posttraumatic SIRS and sepsis.

    PubMed

    Martin, R Shayn; Kincaid, Edward H; Russell, Hyde M; Meredith, J Wayne; Chang, Michael C

    2005-03-01

    Cardiovascular dysfunction associated with the systemic inflammatory response syndrome (SIRS) is caused by a combination of decreased myocardial contractility and low vascular resistance. The contribution of each of these components can be determined at the bedside, and directed therapy can be appropriately initiated. Over an 8-month period of time, 23 consecutive patients who experienced posttraumatic SIRS while still being monitored with a volumetric pulmonary artery catheter (PAC) were prospectively evaluated. Ventricular pressure-volume diagrams were constructed to quantify myocardial contractility and afterload. In a resuscitation protocol, dobutamine was administered to patients with an isolated decrease in contractility, and dopamine or epinephrine was instituted for the combination of reduced contractility and afterload. Variables describing cardiovascular function were measured at the time of resolution of initial shock resuscitation (BASE), at the onset of SIRS (ONSET), and after administration of inotropic or vasoactive agents (TREAT). ONSET was associated with a significant decrease in left ventricular power (LVP) (362 +/- 96 to 235 +/- 55 mmHg.L/min/m(2), P < 0.00001) and stroke work index (SWI) (4670 +/- 1213 to 3060 +/- 848 mmHg.mL/m, P < 0.00001) from BASE. Sixteen patients (70%) demonstrated predominantly decreased contractility, which returned to near BASE values after the administration of dobutamine. The remaining seven patients (30%) had both decreased contractility and afterload, which was treated with dopamine or epinephrine. LVP and SWI significantly increased (235 +/- 55 to 328 +/- 77 mmHg.L/min/m(2), P < 0.00001, and 3060 +/- 848 to 4554 +/- 1423 mmHg.mL/m(2), P < 0.00001, respectively) on the initiation of directed therapy. Specific cardiovascular abnormalities can be identified at the bedside, and this information can guide pharmacologic management. Directed therapy improves cardiovascular function. PMID:15718916

  13. Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine

    PubMed Central

    Zhu, Anita Y.; Zhou, Yeyun; Khan, Saba; Deitsch, Kirk W.; Hao, Quan; Lin, Hening

    2011-01-01

    Plasmodium falciparum Sir2A (PfSir2A), a member of the sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylases, has been shown to regulate the expression of surface antigens to evade the detection by host immune surveillance. It is thought that PfSir2A achieves this by deacetylating histones. However, the deacetylase activity of PfSir2A is weak. Here we present enzymology and structural evidences supporting that PfSir2A catalyzes the hydrolysis of medium and long chain fatty acyl groups from lysine residues more efficiently. Furthermore, P. falciparum proteins are found to contain such fatty acyl lysine modifications that can be removed by purified PfSir2A in vitro. Together, the data suggest that the physiological function of PfSir2A in antigen variation may be achieved by removing medium and long chain fatty acyl groups from protein lysine residues. The robust activity of PfSir2A would also facilitate the development of PfSir2A inhibitors, which may have therapeutic value in malaria treatment. PMID:21992006

  14. Reversible glutathionylation of Sir2 by monothiol glutaredoxins Grx3/4 regulates stress resistance.

    PubMed

    Vall-Llaura, Núria; Reverter-Branchat, Gemma; Vived, Celia; Weertman, Naomi; Rodríguez-Colman, María José; Cabiscol, Elisa

    2016-07-01

    The regulatory mechanisms of yeast Sir2, the founding member of the sirtuin family involved in oxidative stress and aging, are unknown. Redox signaling controls many cellular functions, especially under stress situations, with dithiol glutaredoxins (Grxs) playing an important role. However, monothiol Grxs are not considered to have major oxidoreductase activity. The present study investigated the redox regulation of yeast Sir2, together with the role and physiological impact of monothiol Grx3/4 as Sir2 thiol-reductases upon stress. S-glutathionylation of Sir2 upon disulfide stress was demonstrated both in vitro and in vivo, and decreased Sir2 deacetylase activity. Physiological levels of nuclear Grx3/4 can reverse the observed post-translational modification. Grx3/4 interacted with Sir2 and reduced it after stress, thereby restoring telomeric silencing activity. Using site-directed mutagenesis, key cysteine residues at the catalytic domain of Sir2 were identified as a target of S-glutathionylation. Mutation of these residues resulted in cells with increased resistance to disulfide stress. We provide new mechanistic insights into Grx3/4 regulation of Sir2 by S-deglutathionylation to increase cell resistance to stress. This finding offers news perspectives on monothiol Grxs in redox signaling, describing Sir2 as a physiological substrate regulated by S-glutathionylation. These results might have a relevant role in understanding aging and age-related diseases. PMID:27085841

  15. Involvement of Daphnia pulicaria Sir2 in regulating stress response and lifespan

    PubMed Central

    Schumpert, Charles A.; Anderson, Craig; Dudycha, Jeffry L.; Patel, Rekha C.

    2016-01-01

    The ability to appropriately respond to proteotoxic stimuli is a major determinant of longevity and involves induction of various heat shock response (HSR) genes, which are essential to cope with cellular and organismal insults throughout lifespan. The activity of NAD+-dependent deacetylase Sir2, originally discovered in yeast, is known to be essential for effective HSR and longevity. Our previous work on HSR in Daphnia pulicaria indicated a drastic reduction of the HSR in older organisms. In this report we investigate the role of Sir2 in regulating HSR during the lifespan of D. pulicaria. We cloned Daphnia Sir2 open reading frame (ORF) to characterize the enzyme activity and confirmed that the overall function of Sir2 was conserved in Daphnia. The Sir2 mRNA levels increased while the enzyme activity declined with age and considering that Sir2 activity regulates HSR, this explains the previously observed age-dependent decline in HSR. Finally, we tested the effect of Sir2 knockdown throughout adult life by using our new RNA interference (RNAi) method by feeding. Sir2 knockdown severely reduced both the median lifespan as well as significantly increased mortality following heat shock. Our study provides the first characterization and functional study of Daphnia Sir2. PMID:26978617

  16. Involvement of Daphnia pulicaria Sir2 in regulating stress response and lifespan.

    PubMed

    Schumpert, Charles A; Anderson, Craig; Dudycha, Jeffry L; Patel, Rekha C

    2016-02-01

    The ability to appropriately respond to proteotoxic stimuli is a major determinant of longevity and involves induction of various heat shock response (HSR) genes, which are essential to cope with cellular and organismal insults throughout lifespan. The activity of NAD+-dependent deacetylase Sir2, originally discovered in yeast, is known to be essential for effective HSR and longevity. Our previous work on HSR inDaphnia pulicaria indicated a drastic reduction of the HSR in older organisms. In this report we investigate the role of Sir2 in regulating HSR during the lifespan of D. pulicaria. We cloned Daphnia Sir2 open reading frame (ORF) to characterize the enzyme activity and confirmed that the overall function of Sir2 was conserved in Daphnia. The Sir2 mRNA levels increased while the enzyme activity declined with age and considering that Sir2 activity regulates HSR, this explains the previously observed age-dependent decline in HSR. Finally, we tested the effect of Sir2 knockdown throughout adult life by using our new RNA interference (RNAi) method by feeding. Sir2 knockdown severely reduced both the median lifespan as well as significantly increased mortality following heat shock. Our study provides the first characterization and functional study of Daphnia Sir2. PMID:26978617

  17. Color Image of Death Valley, California from SIR-C

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This radar image shows the area of Death Valley, California and the different surface types in the area. Radar is sensitive to surface roughness with rough areas showing up brighter than smooth areas, which appear dark. This is seen in the contrast between the bright mountains that surround the dark, smooth basins and valleys of Death Valley. The image shows Furnace Creek alluvial fan (green crescent feature) at the far right, and the sand dunes near Stove Pipe Wells at the center. Alluvial fans are gravel deposits that wash down from the mountains over time. Several other alluvial fans (semicircular features) can be seen along the mountain fronts in this image. The dark wrench-shaped feature between Furnace Creek fan and the dunes is a smooth flood-plain which encloses Cottonball Basin. Elevations in the valley range from 70 meters (230 feet) below sea level, the lowest in the United States, to more than 3,300 meters (10,800 feet) above sea level. Scientists are using these radar data to help answer a number of different questions about Earth's geology including how alluvial fans form and change through time in response to climatic changes and earthquakes. The image is centered at 36.629 degrees north latitude, 117.069 degrees west longitude. Colors in the image represent different radar channels as follows: red =L-band horizontally polarized transmitted, horizontally polarized received (LHH); green =L-band horizontally transmitted, vertically received (LHV) and blue = CHV.

    SIR-C/X-SAR is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves allowing detailed observations at any time, regardless of weather or sunlight conditions. SIR-C/X-SAR uses three microwave wavelengths: L-band (24 cm), C-band (6 cm) and X-band (3 cm). The multi-frequency data will be used by the international scientific community to better understand the global environment and how it is changing. The SIR-C/X-SAR data, complemented by aircraft and ground

  18. Traffic-driven SIR epidemic spreading in networks

    NASA Astrophysics Data System (ADS)

    Pu, Cunlai; Li, Siyuan; Yang, XianXia; Xu, Zhongqi; Ji, Zexuan; Yang, Jian

    2016-03-01

    We study SIR epidemic spreading in networks driven by traffic dynamics, which are further governed by static routing protocols. We obtain the maximum instantaneous population of infected nodes and the maximum population of ever infected nodes through simulation. We find that generally more balanced load distribution leads to more intense and wide spread of an epidemic in networks. Increasing either average node degree or homogeneity of degree distribution will facilitate epidemic spreading. When packet generation rate ρ is small, increasing ρ favors epidemic spreading. However, when ρ is large enough, traffic congestion appears which inhibits epidemic spreading.

  19. Effects of population mixing on the spread of SIR epidemics

    NASA Astrophysics Data System (ADS)

    Fukś, H.; Lawniczak, A. T.; Duchesne, R.

    2006-03-01

    We study dynamics of spread of epidemics of SIR type in a realistic spatially-explicit geographical region, Southern and Central Ontario, using census data obtained from Statistics Canada, and examine the role of population mixing in epidemic processes. Our model incorporates the random nature of disease transmission, the discreteness and heterogeneity of distribution of host population.We find that introduction of a long-range interaction destroys spatial correlations very easily if neighbourhood sizes are homogeneous. For inhomogeneous neighbourhoods, very strong long-range coupling is required to achieve a similar effect. Our work applies to the spread of influenza during a single season.

  20. Sir Arthur Conan Doyle: the author was an ophthalmologist.

    PubMed

    Ravin, J G; Migdal, C

    1995-01-01

    Sir Arthur Conan Doyle created the famous detective Sherlock Holmes, and his faithful companion, Dr. Watson. A graduate of the University of Edinburgh Medical School, Doyle (1859-1930) spent nearly ten years practicing medicine. During his years in general practice, Doyle gave particular attention to the eye. Later, he studied ophthalmology in Vienna and spent time with the best known ophthalmologist in Paris. He returned to London and established an ophthalmological office near Harley Street. His literary career soon overtook the medical career, but he made many references to medicine, and to ophthalmology in particular in his writings. PMID:8599161

  1. Sir Ronald A. Fisher and the International Biometric Society.

    PubMed

    Billard, Lynne

    2014-06-01

    The year 2012 marks the 50th anniversary of the death of Sir Ronald A. Fisher, one of the two Fathers of Statistics and a Founder of the International Biometric Society (the "Society"). To celebrate the extraordinary genius of Fisher and the far-sighted vision of Fisher and Chester Bliss in organizing and promoting the formation of the Society, this article looks at the origins and growth of the Society, some of the key players and events, and especially the roles played by Fisher himself as the First President. A fresh look at Fisher, the man rather than the scientific genius is also presented. PMID:24499157

  2. 1. Historic American Buildings Survey James F. and Jean B. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey James F. and Jean B. O'Gorman, Photographers October 1963 EXTERIOR FROM THE SOUTHEAST Gift of James F. and Jean B. O'Gorman - Stephen Higginson Jr. House, 7 Kirkland Street, Cambridge, Middlesex County, MA

  3. 2. Historic American Buildings Survey James F. and Jean B. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey James F. and Jean B. O'Gorman, Photographers October 1963 EXTERIOR FROM THE SOUTHWEST Gift of James F. and Jean B. O'Gorman - Stephen Higginson Jr. House, 7 Kirkland Street, Cambridge, Middlesex County, MA

  4. 5. Historic American Buildings Survey James F. and Jean B. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey James F. and Jean B. O'Gorman, Photographers October 1963 MID-19th-CENTURY MANTELPIECE IN EAST CHAMBER, SECOND FLOOR Gift of James F. and Jean B. O'Gorman - Stephen Higginson Jr. House, 7 Kirkland Street, Cambridge, Middlesex County, MA

  5. 4. Historic American Buildings Survey James F. and Jean B. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey James F. and Jean B. O'Gorman, Photographers October 1963 LATE 19th-CENTURY MANTELPIECE IN FIRST FLOOR ROOM Gift of James F. and Jean B. O'Gorman - Stephen Higginson Jr. House, 7 Kirkland Street, Cambridge, Middlesex County, MA

  6. 3. Historic American Buildings Survey James F. and Jean B. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey James F. and Jean B. O'Gorman, Photographers October 1963 ORIGINAL MANTELPIECE AND WINDOW SHUTTERS, FIRST FLOOR Gift of James F. and Jean B. O'Gorman - Stephen Higginson Jr. House, 7 Kirkland Street, Cambridge, Middlesex County, MA

  7. 75 FR 13323 - James A. Fitzpatrick Nuclear Power Plant; Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION James A. Fitzpatrick Nuclear Power Plant; Exemption 1.0 Background Entergy Nuclear Operations, Inc. (the licensee) is the holder of Facility Operating License No. DPR-59, which authorizes operation of the James A. FitzPatrick Nuclear Power Plant...

  8. 3. Photocopy of Plate #13, 'Interior of St. James, Thirtyeighth ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of Plate #13, 'Interior of St. James, Thirty-eighth and Chestnut Sts.', in Architectural Album of Edwin F. Durang and Son, 1200. Chestnut St., Philadelphia (a privately bound volume). Exact date not noted. - St. James Roman Catholic Church, 3728 Chestnut Street, Philadelphia, Philadelphia County, PA

  9. 2. Photocopy of Plate #12, 'St. James Church, Thirtyeighth and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of Plate #12, 'St. James Church, Thirty-eighth and Chestnut Sts.', in Architectural Album of Edwin F. Durang and Son, 1200 Chestnut St., Philadelphia (a privately bound volume). Exact date not noted. - St. James Roman Catholic Church, 3728 Chestnut Street, Philadelphia, Philadelphia County, PA

  10. 1. VIEW OF JAMES H. LANE BARN (HEREAFTER LANE BARN) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW OF JAMES H. LANE BARN (HEREAFTER LANE BARN) FROM L.D.S. CHURCH GROUNDS ON IDAHO HIGHWAY 26, APPROXIMATELY 1/4 MILE EAST OF THE MAIN INTERSECTION OF RICHFIELD, IDAHO. CAMERA IS POINTING SOUTH. - James H. Lane Ranch, Barn, One Mile South of Richfield on Highway 26, Richfield, Lincoln County, ID

  11. Metacognition and Self-Regulation in James, Piaget, and Vygotsky

    ERIC Educational Resources Information Center

    Fox, Emily; Riconscente, Michelle

    2008-01-01

    This article investigates the intertwined constructs of metacognition and self-regulation as they emerge in the works and theories of James, Piaget, and Vygotsky. To coordinate this exploration, we use an interpretive framework based on the relation of subject and object. In this framework, James's perspective on metacognition and self-regulation…

  12. 18. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. John and James Dobson Carpet Mill, East and West parcels, site plan-lower left, and surrounding environs, 1925. Bromley, George Washington and Bromley, Walter Scott. Atlas of the City of Philadelphia (North Philadelphia), Philadelphia, Pennsylvania: George W. and Walter S. Bromley, 1925, p. 106. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  13. 17. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. John and James Dobson Carpet Mill, East and West Parcels, site plan, revised through 1914. Hexamer, Ernest and Son. Insurance Maps of the City of Philadelphia, Vol. 21., Philadelphia, Pennsylvania: E. Hexamer and Son, 1893. Revisions, 1914, p. 446. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  14. 14. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. John and James Dobson Carpet Mill, East and West parcels, site plan, revised through 1895. Hexamer, Ernest and Son. Insurance Maps of the City of Philadelphia, Vol. 21., Philadelphia, Pennsylvania: E. Hexamer and Son, 1893. Revisions, 1895, p. 446. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  15. 16. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. John and James Dobson Carpet Mill, East and West parcels, site plan-right, and western environs, 1908. Smith, Elvino Victor. Atlas of the 38th and Part of the 37th Ward of the City of Philadelphia, Philadelphia, Pennsylvania: Elvino V. Smith, 1908, Plate 24. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  16. 11. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. John and James Dobson Carpet Mill, East and West parcels, site plan-upper left, elevation-lower left, and survey-right, 1877. Hexamer, Ernest and Son. Hexamer General Surveys, 1867-1895, Philadelphia, Pennsylvania: E. Hexamer and Son, 1877, pp. 1095-1096. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  17. 19. John and James Dobson Carpet Mills, West parcel, topographical ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. John and James Dobson Carpet Mills, West parcel, topographical plan, 1986. Barton and Martin, Engineers. 'Topographical Plan for Dobson Mills.' Prepared for Rouse Urban Housing, Inc., Philadelphia, Pennsylvania, 1986. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  18. The National Writing Project: A Best Idea from James Gray.

    ERIC Educational Resources Information Center

    Jago, Carol

    2003-01-01

    Discusses how James Gray, founder of the Bay Area Writing Project and later the National Writing Project, began with a simple idea--successful teachers are the best teachers of teachers. Describes how James Gray laid a foundation for what has become a national network with 175 sites across the nation, providing a professional home for thousands of…

  19. 10. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. John and James Dobson Carpet Mill, East and West parcels, site plan-lower right, and surrounding environs, 1875. Hopkins, Griffith Morgan. City Atlas of Philadelphia by Wards, 7 vols., Philadelphia, Pennsylvania: G. M. Hopkins and Co., 1875, pp. 46-47. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  20. 9. John and James Dobson Carpet Mill, portion of West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. John and James Dobson Carpet Mill, portion of West parcel, site plan-left, elevation-upper right, and survey-lower right, 1873. Hexamer, Ernest and Son. Hexamer General Surveys 1867-1895, Philadelphia, Pennsylvania: E. Hexamer and Son, 1873, pp. 670-671. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  1. 13. John and James Dobson Carpet Mill, East and West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. John and James Dobson Carpet Mill, East and West parcels, site plan-upper left, elevation-upper right, and survey-below, 1885. Hexamer, Ernest and Son. Hexamer General Surveys, 1867-1895, Philadelphia, Pennsylvania: E. Hexamer and Son, 1885, pp. 1890-1891. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  2. PEOPLE IN PHYSICS: Interview with Sir Arnold Wolfendale FRS

    NASA Astrophysics Data System (ADS)

    Wiltsher, Conducted by Nicholas

    1997-11-01

    Sir Arnold Wolfendale was born on 25 June 1927, the son of Arnold and Doris Wolfendale. His BSc in Physics with First Class honours from the University of Manchester in 1948 was followed by a PhD in 1953 and a DSc in 1970. He was elected a Fellow of the Royal Society in 1977, and of the Royal Astronomical Society in 1973. In 1951 he married Audrey Darby, and they have twin sons. Sir Arnold's career has included lecturing posts at the Universities of Manchester, Durham, Ceylon and Hong Kong, and he was head of department at Durham. He retired from teaching in 1992 and was knighted in 1995. From 1991 to 1995 he was Astronomer Royal. Since 1996 he has been Professor of Experimental Physics with the Royal Institution of Great Britain. He has given lectures in many countries and in many places, and has had several books published on the subject of cosmic rays and astrophysics. He lives in Durham.

  3. Advanced photomask reconstruction with the Seiko SIR 3000

    NASA Astrophysics Data System (ADS)

    Ruatta, Stephen A.; Smith, Eryn L.; Yasaka, Anto

    1997-02-01

    OPC and other complicated geometric structures are increasingly common on production masks. These features may be small, have highly irregular shapes and may not be repeated in a nearby region. These features make it difficult for a repair operator to know where the defect stops and the desired pattern begins. We are increasingly called upon to write masks with these complicated patterns, high densities and long write times. In order to meet our customers demand for shorter turnaround times and high throughput, it makes sense to implement new, more sophisticated repair techniques. We have recently acquired a new, state of the art Seiko SIR3000 FIB (focused ion beam) mask repair system. This system is a sophisticated secondary ion mass spectrometer (SIMS) that uses a focused primary beam of gallium ions to both image and repair mask defects. Both opaque and clear defects can be reconstructed by the gallium beam. The SIR3000 system uses a proprietary material (alpha-gas) to reduce glass damage caused by the sputtering process. We have performed some preliminary measurements to determine the extent of the glass damage and performed some introductory work into methods of reducing the damage further. We present some of the data we use to monitor its performance, a number of examples illustrating its utility and our expectations for the tool in the near future.

  4. Sir William Osler's speech at Troy: a Trojan horse?

    PubMed

    Moran, Michael E

    2012-01-01

    Troy, New York, is a city of 55,000 people in upstate New York located along the Hudson River. A city of surprisingly rich cultural heritage, it was the home of New York state's first hospital outside New York City. The 50th anniversary celebration of Troy's hospital brought William Osler to the city as the keynote speaker. This speech, delivered on November 28, 1900, is one of Sir William's less well known addresses. Osler began his comments with Sir Thomas More's Utopia and talked at length about the hospital, its obligations, the influences it has upon the community, and the role of physicians and surgeons. He broached one of his old saws, the salary of attending physicians and their needed role in hospital management. His words were published in the diamond jubilee's records, but the hospital did not outlive its prominent guest professor, and it closed its doors in 1914. Just like the great historical city of Troy, New York's own Troy was on the brink of decline, and its hospital would be the first fatality. Therefore, it is almost prescient that the words of Osler, taken into historical context juxtaposed against the socioeconomic forces at work, are akin to the Greek's offering of a wooden edifice to end the Trojan War. PMID:22275788

  5. Multiple incidence angle SIR-B experiment over Argentina

    NASA Technical Reports Server (NTRS)

    Cimino, Jobea; Casey, Daren; Wall, Stephen; Brandani, Aldo; Domik, Gitta; Leberl, Franz

    1986-01-01

    The Shuttle Imaging Radar (SIR-B), the second synthetic aperture radar (SAR) to fly aboard a shuttle, was launched on October 5, 1984. One of the primary goals of the SIR-B experiment was to use multiple incidence angle radar images to distinguish different terrain types through the use of their characteristic backscatter curves. This goal was accomplished in several locations including the Chubut Province of southern Argentina. Four descending image acquisitions were collected providing a multiple incidence angle image set. The data were first used to assess stereo-radargrammetric techniques. A digital elevation model was produced using the optimum pair of multiple incidence angle images. This model was then used to determine the local incidence angle of each picture element to generate curves of relative brightness vs. incidence angle. Secondary image products were also generated using the multi-angle data. The results of this work indicate that: (1) various forest species and various structures of a single species may be discriminated using multiple incidence angle radar imagery, and (2) it is essential to consider the variation in backscatter due to a variable incidence angle when analyzing and comparing data collected at varying frequencies and polarizations.

  6. James Astor in conversation with Warren Colman.

    PubMed

    Astor, James

    2013-11-01

    In this interview with Warren Colman, James Astor speaks about his development as a Jungian analyst from his own experience of personal analysis in the 1960s to his recent retirement from clinical practice. The discussion covers his long association with Michael Fordham, the child analytic training at the SAP, the infant observation seminars with Fordham and Gianna Henry through which Fordham was able to make new discoveries about infant development, his experience of supervision with Donald Meltzer and the development of his own thinking through a series of papers on the analytic process, supervision and the relation between language and truth. The interview concludes with reflections about the legacy of Michael Fordham and the future of analytic work. PMID:24237210

  7. Overview of the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Clampin, Mark

    2011-01-01

    The James Webb Space Telescope (JWST) is a large aperture (6.5 meter), cryogenic space telescope with a suite of near and mid-infrared instruments covering the wavelength range of 0.6 microns to 28 microns. JWST's primary science goals are to detect and characterize the first galaxies, and study the assembly of galaxies, star formation, and the formation of evolution of planetary systems. JWST is a segmented mirror telescope operating at approx.40K, a temperature achieved by passive cooling of the observatory, via a large, 5-layer membrane-based sunshield. We will review the scientific capabilities of JWST in the context of their synergy with survey facilities, and with the next generation of ground-based Extremely Large Telescopes. We will also present an overview of the observatory design, and report on recent progress in the construction of the observatory and its science instruments.

  8. James Webb Space Telescope Station-keeping

    NASA Technical Reports Server (NTRS)

    Beckman, Mark

    2003-01-01

    The James Webb Space Telescope (JWST) is planned to be launched in 2011 to the Sun- Earth L2 libration point. The resultant delta-Vs (dV) from momentum unloads will perturb the orbit and necessitate frequent station-keeping maneuvers. The station-keeping dV budget is highly sensitive to the direction of the resultant dV vector. A simple spacecraft reorientation prior to each momentum unload will allow some control over the direction of the resultant dV vector. For each inertial momentum vector direction, an optimum spacecraft attitude is determined which gives a resultant dV vector that requires the least amount of station-keeping dV. Using this procedure, the station-keeping dV budget for JWST can be reduced by 60%.

  9. Remembering James Alan Bassham (1922-2012).

    PubMed

    Govindjee; Bassham, Helen; Bassham, Susan

    2016-04-01

    James Alan Bassham, known to many as Al, was born on November 26, 1922, in Sacramento, California (CA), USA. He died on November 19, 2012, in El Cerrito, CA. To celebrate his life at his 3rd death anniversary, we present here a brief biography, comments on his discoveries, but most importantly, remembrances from family and friends; we remember this wonderful and modest person who had played a major pivotal role in the discoveries that led to what he would like to call the P(hotosynthetic) C(arbon) R(eduction) cycle, known to many as the Calvin Cycle, the Calvin-Benson Cycle, or the Calvin-Benson-Bassham Cycle. Based on a personal request by Bassham himself to one of us (Govindjee), we refrain from including his name in the cycle-in recognition of his many students and associates he would have liked to honor. PMID:26582593

  10. James Webb Space Telescope Project (JWST) Overview

    NASA Technical Reports Server (NTRS)

    Dutta, Mitra

    2008-01-01

    This presentation provides an overview of the James Webb Space Telescope (JWST) Project. The JWST is an infrared telescope designed to collect data in the cosmic dark zone. Specifically, the mission of the JWST is to study the origin and evolution of galaxies, stars and planetary systems. It is a deployable telescope with a 6.5 m diameter, segmented, adjustable primary mirror. outfitted with cryogenic temperature telescope and instruments for infrared performance. The JWST is several times more sensitive than previous telescope and other photographic and electronic detection methods. It hosts a near infrared camera, near infrared spectrometer, mid-infrared instrument and a fine guidance sensor. The JWST mission objection and architecture, integrated science payload, instrument overview, and operational orbit are described.

  11. William James, Gustav Fechner, and Early Psychophysics

    PubMed Central

    Hawkins, Stephanie L.

    2011-01-01

    American psychologist and philosopher William James devoted the entirety of his career to exploring the nature of volition, as expressed by such phenomena as will, attention, and belief. As part of that endeavor, James’s unorthodox scientific pursuits, from his experiments with nitrous oxide and hallucinogenic drugs to his investigation of spiritualist mediums, represent his attempt to address the “hard problems” of consciousness for which his training in brain physiology and experimental psychology could not entirely account. As a student, James’s reading in chemistry and physics had sparked his interest in the concepts of energy and force, terms that he later deployed in his writing about consciousness and in his arguments against philosophical monism and scientific materialism, as he developed his “radically empiricist” ideas privileging discontinuity and plurality. Despite James’s long campaign against scientific materialism, he was, however, convinced of the existence of a naturalistic explanation for the more “wayward and fitful” aspects of mind, including transcendent experiences associated with hysteria, genius, and religious ecstasy. In this paper, I examine aspects of James’s thought that are still important for contemporary debates in psychology and neuroscience: his “transmission theory” of consciousness, his ideas on the “knowing of things together,” and, finally, the related concept of “the compounding of consciousness,” which postulates the theoretical possibility for individual entities within a conscious system of thought to “know” the thoughts of others within the system. Taken together, these ideas suggest that James, in spite of, or perhaps because of, his forays into metaphysics, was working toward a naturalistic understanding of consciousness, what I will term a “distributive model,” based on his understanding of consciousness as an “awareness” that interacts dynamically within, and in relation to

  12. Heat Stress-Induced Cup9-Dependent Transcriptional Regulation of SIR2

    PubMed Central

    Laskar, Shyamasree; K, Sheeba; Bhattacharyya, Mrinal K.; Nair, Achuthsankar S.; Dhar, Pawan

    2014-01-01

    The epigenetic writer Sir2 maintains the heterochromatin state of chromosome in three chromosomal regions, namely, the silent mating type loci, telomeres, and the ribosomal DNA (rDNA). In this study, we demonstrated the mechanism by which Sir2 is regulated under heat stress. Our study reveals that a transient heat shock causes a drastic reduction in the SIR2 transcript which results in sustained failure to initiate silencing for as long as 90 generations. Hsp82 overexpression, which is the usual outcome of heat shock treatment, leads to a similar downregulation of SIR2 transcription. Using a series of genetic experiments, we have established that heat shock or Hsp82 overexpression causes upregulation of CUP9 that, in turn, represses SIR2 transcription by binding to its upstream activator sequence. We have mapped the cis regulatory element of SIR2. Our study shows that the deletion of cup9 causes reversal of the Hsp82 overexpression phenotype and upregulation of SIR2 expression in heat-induced Hsp82-overexpressing cells. On the other hand, we found that Cup9 overexpression represses SIR2 transcription and leads to a failure in the establishment of heterochromatin. The results of our study highlight the mechanism by which environmental factors amend the epigenetic configuration of chromatin. PMID:25384977

  13. Evaluation of SIR-B imagery for geologic and geomorphic mapping, hydrology, and oceanography in Australia

    NASA Technical Reports Server (NTRS)

    Honey, F. R.; Simpson, C. J.; Huntington, J.; Horwitz, R.; Byrne, G.; Nilsson, C.

    1984-01-01

    The objectives of a study to evaluate the potential of Shuttle Imaging Radar-B (SIR-B) imagery for various applications are outlined. Specific goals include: the development of techniques for registration multiple acquisition, varied illumination, and incidence-angle SIR-B imagery, and a model for estimation of the relative contributions to the backscattered radiation of topography, surface roughness, and dielectric and conductivity components; (2) the evaluation of SIR-B imagery for delineation of agricultural lands affected by secondary salinity in the southwest and southeast agricultural regions of Australia; (3) the development of techniques for application of SIR-B imagery for geologic, geomorphologic and soils mapping and mineral exploration; and (4) the evaluation of the use of SIR-B imagery in determining ocean currents, current shear patterns, internal waves and bottom features for specific locations off the Australian coast.

  14. [Basic concept and definition of SIRS and sepsis--present consideration and future perspectives].

    PubMed

    Hirasawa, Hiroyuki; Oda, Shigeto; Matsuda, Kenichi; Watanabe, Eizo

    2004-12-01

    SIRS (systemic inflammatory response syndrome) is thought to be caused by hypercytokinemia. On the other hand, interleukin-6 (IL-6) is reported to be one of most easily measurable cytokines and we found that IL-6 blood levels on SIRS patients are above 1,500 pg/ml which is compatible to the previously reported values. Since only 6% of SIRS patients developed MOF according to our own data, we need not overestimate SIRS as a grave clinical signs. On the other hand, it is reported that cytokine-related genetic polymorphism may affect the cytokine production following insult, or may affect the development of SIRS following insult. Therefore, we must also consider genetic aspect of cytokine biology in future study. PMID:15597782

  15. Sir Robert Jones: orthopaedic surgeon and war hero.

    PubMed

    Di Matteo, Berardo; Tarabella, Vittorio; Filardo, Giuseppe; Tomba, Patrizia; Viganò, Anna; Kon, Elizaveta; Marcacci, Maurilio

    2015-05-01

    The First World War was a very harsh conflict and statistics recorded a great number of victims, both soldiers and civilians. One hundred years later, the whole world is commemorating the Great War by celebrating people and events that contributed to shaping the XX century. Beyond remembering political figures, war heroes or even famous battles, it is also important to underline the contribution of those who devoted their efforts to improve the living conditions during war campaigns. This is the case of Sir Robert Jones, one of the fathers of XX century orthopaedics, who contributed to re-organize the military medical assistance during war times and whose teachings, coming directly from his "on the field" experience, inspired an entire generation of European surgeons. PMID:25435061

  16. Fatal SIR diseases and rational exemption to vaccination.

    PubMed

    d'Onofrio, Alberto; Manfredi, Piero; Salinelli, Ernesto

    2008-12-01

    A challenge to disease control in modern societies is the spread of rational exemption to vaccination as a consequence of the rational comparison between the steadily declining risk of infection and the risk of side effects from the vaccine. Here, we consider rational exemption in an susceptible-infectious-removed (SIR) model with information-dependent vaccination where individuals use information on the disease's mortality as their information set. Using suitable assumptions on the dynamics of the population, we show the dynamic implications of the interaction between rational exemption, current and delayed information and the risk of death by the disease. In particular, we illustrate the onset of the long cycles caused by rational exemption when vaccination decisions are based on delayed informations. PMID:18840601

  17. Sir Robert Ball: Victorian Astronomer and Lecturer par excellence

    NASA Astrophysics Data System (ADS)

    Jones, R. I. G.

    2005-12-01

    Between 1875 and 1910 Sir Robert Stawell Ball gave an estimated 2,500 lectures in towns and cities all over the British Isles and abroad. This paper traces his lecturing career from its beginnings in Ireland to the triumphs of the Royal Institution, and on lecture tours in the United States of America. After a period in mathematics and mechanics, he became a populariser of science, especially astronomy, and found fame and fortune among the working classes and the aristocracy. What motivated him to tireless travels is uncertain, but it might have been that it was rewarding, financially and to his reputation. Whatever his motives, contemporary accounts are clear that BallÕs lectures were extremely popular and well-received.

  18. Sir Francis Galton and the birth of eugenics.

    PubMed

    Gillham, N W

    2001-01-01

    The eugenics movement was initiated by Sir Francis Galton, a Victorian scientist. Galton's career can be divided into two parts. During the first, Galton was engaged in African exploration, travel writing, geography, and meteorology. The second part began after he read the Origin of Species by his cousin Charles Darwin. The book convinced Galton that humanity could be improved through selective breeding. During this part of his career he was interested in the factors that determine what he called human "talent and character" and its hereditary basis. Consequently, he delved into anthropometrics and psychology and played a major role in the development of fingerprinting. He also founded the field of biometrics, inventing such familiar statistical procedures as correlation and regression analysis. He constructed his own theory of inheritance in which nature and not nurture played the leading role. He actively began to promote eugenics and soon gained important converts. PMID:11700278

  19. SIRS Dynamics on Random Networks: Simulations and Analytical Models

    NASA Astrophysics Data System (ADS)

    Rozhnova, Ganna; Nunes, Ana

    The standard pair approximation equations (PA) for the Susceptible-Infective-Recovered-Susceptible (SIRS) model of infection spread on a network of homogeneous degree k predict a thin phase of sustained oscillations for parameter values that correspond to diseases that confer long lasting immunity. Here we present a study of the dependence of this oscillatory phase on the parameter k and of its relevance to understand the behaviour of simulations on networks. For k = 4, we compare the phase diagram of the PA model with the results of simulations on regular random graphs (RRG) of the same degree. We show that for parameter values in the oscillatory phase, and even for large system sizes, the simulations either die out or exhibit damped oscillations, depending on the initial conditions. This failure of the standard PA model to capture the qualitative behaviour of the simulations on large RRGs is currently being investigated.

  20. Sir Harry Sinderson Pasha and Iraq's first medical school.

    PubMed

    Al-Fattal, Sa'ad

    2013-08-01

    During the early twentieth century, the medical status of Mesopotamia, later Iraq, was very bad due to the lack of sanitation and recurrent epidemics and it was rife with endemic diseases including bilharziasis, tuberculosis and malaria. Medical care was poor, with few hospitals and doctors. The condition improved slowly with the return of a few Iraqi doctors who trained outside Iraq, in Turkey, Syria and Lebanon, and with the arrival of British Medical personnel, during and after the First World War, principally Sir Harry Sinderson who was one of the most influential figures in recent Iraqi medical and political history. He had the distinctive role of being one of the founders and the Dean of the first Iraqi medical college. During his service until his retirement in 1946 he achieved, with tireless effort, exceptionally high standards and brought fame and prestige to the new medical college in record time. He attained his goal of training at least 500 local doctors. PMID:24585764

  1. The SIRS Model of Epidemic Spreading in Virtual Society

    NASA Astrophysics Data System (ADS)

    Grabowski, A.; Kosiński, R.

    2008-09-01

    Dedicated to Professor Dietrich Stauffer on the occasion of his 65th birthday The phenomenon of epidemic spreading in a real social network is described and investigated numerically. On the basis of data concerning amount of time devoted daily to social interactions, the influence of human activity on spreading process is investigated in the frame of SIRS model. It was found that the activity of an individual is positively correlated with its connectivity and the relation has power law form. The influence of control measures on the spreading process is investigated as a function of initial conditions. The cost-effectiveness of mass immunizations campaigns and target vaccinations is compared. It was found that the form of activity distribution has significant influence on the spreading phenomena in the network.

  2. Sir William Herschel's notebooks - Abstracts of solar observations

    NASA Technical Reports Server (NTRS)

    Hoyt, Douglas V.; Schatten, Kenneth H.

    1992-01-01

    An introduction to the background of Sir William Herschel's notebooks and the historical context within which his observations were made are provided. The observations have relevance in reconstructing solar behavior, as discussed in a separate analysis paper by Hoyt and Schatten (1992), and in understanding active features on the sun such as faculae. The text of Herschel's notebooks with modern terms used throughout forms the body of this paper. The complete text has not previously been published and is not easily accessible to scholars. Herschel used different words for solar features than are used today, and thus, for clarity, his terminology is changed on two occasions. A glossary explains the terminology changed. In the text of the notebooks, several contemporaries are mentioned; a brief description of Herschel's colleagues is provided.

  3. Development of a calibration workstation for SIR-C

    NASA Technical Reports Server (NTRS)

    Madsen, S. N.; Dubois, P.; Freeman, A.; Norikane, L.; Shaffer, S.; Shimada, J.

    1991-01-01

    The paper describes the status of a comprehensive synthetic aperture radar (SAR) software package developed specifically to aid the calibration of a multifrequency and multipolarization radar like the Shuttle Imaging Radar, SIR-C. The primary data types processed are engineering telemetry, point targets (corner reflectors and polarimetric active radar calibrators), distributed targets (clutter), tone-generators, and ground receivers. The parameters derived to aid the calibration of the production processor include measurements of relative radiometric channel to channel imbalance, absolute calibration constants, antenna pattern corrections, noise levels, polarimetric cross-talk, and geometric offsets. The software reports standard performance measurements such as resolution, peak and integrated sidelobes, radiometric response accuracy, and geometrical distortions such as scale errors, position bias and standard deviation, and image skew. Furthermore, the inclusion of software to allow updates of the shuttle-state vector (position and velocity) is considered.

  4. Development of a calibration workstation for SIR-C

    NASA Astrophysics Data System (ADS)

    Madsen, S. N.; Dubois, P.; Freeman, A.; Norikane, L.; Shaffer, S.; Shimada, J.

    The paper describes the status of a comprehensive synthetic aperture radar (SAR) software package developed specifically to aid the calibration of a multifrequency and multipolarization radar like the Shuttle Imaging Radar, SIR-C. The primary data types processed are engineering telemetry, point targets (corner reflectors and polarimetric active radar calibrators), distributed targets (clutter), tone-generators, and ground receivers. The parameters derived to aid the calibration of the production processor include measurements of relative radiometric channel to channel imbalance, absolute calibration constants, antenna pattern corrections, noise levels, polarimetric cross-talk, and geometric offsets. The software reports standard performance measurements such as resolution, peak and integrated sidelobes, radiometric response accuracy, and geometrical distortions such as scale errors, position bias and standard deviation, and image skew. Furthermore, the inclusion of software to allow updates of the shuttle-state vector (position and velocity) is considered.

  5. Precipitation measurement using SIR-C: A feasibility study

    NASA Technical Reports Server (NTRS)

    Ahamad, Atiq; Moore, Richard K.

    1993-01-01

    A precipitation detection and measurement experiment is planned for the SIR-C/X-SAR mission. This study was conducted to determine under what conditions an off-nadir experiment is feasible. The signal-to-clutter ratio, the signal-to-noise ratio, and the minimum detectable rain rate were investigated. Available models, used in previous studies, were used for the surface clutter and the rain echo. The study also considers the attenuation of the returns at X band. It was concluded that an off-nadir rain-measurement experiment is feasible only for rain rates greater than 10 mm/hr for look angles greater than 60 deg. For the range of look angles 5 less than theta(sub 1) less than 50, the rain rate required is very high for adequate signal-to-clutter ratio, and hence the feasibility of the experiment.

  6. SIR dynamics in random networks with heterogeneous connectivity.

    PubMed

    Volz, Erik

    2008-03-01

    Random networks with specified degree distributions have been proposed as realistic models of population structure, yet the problem of dynamically modeling SIR-type epidemics in random networks remains complex. I resolve this dilemma by showing how the SIR dynamics can be modeled with a system of three nonlinear ODE's. The method makes use of the probability generating function (PGF) formalism for representing the degree distribution of a random network and makes use of network-centric quantities such as the number of edges in a well-defined category rather than node-centric quantities such as the number of infecteds or susceptibles. The PGF provides a simple means of translating between network and node-centric variables and determining the epidemic incidence at any time. The theory also provides a simple means of tracking the evolution of the degree distribution among susceptibles or infecteds. The equations are used to demonstrate the dramatic effects that the degree distribution plays on the final size of an epidemic as well as the speed with which it spreads through the population. Power law degree distributions are observed to generate an almost immediate expansion phase yet have a smaller final size compared to homogeneous degree distributions such as the Poisson. The equations are compared to stochastic simulations, which show good agreement with the theory. Finally, the dynamic equations provide an alternative way of determining the epidemic threshold where large-scale epidemics are expected to occur, and below which epidemic behavior is limited to finite-sized outbreaks. PMID:17668212

  7. Science with the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2012-01-01

    The science objectives of the James Webb Space Telescope fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and black holes within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and to investigate the potential for life in those systems. These four science themes were used to establish the design requirements for the observatory and instrumentation. Since Webb's capabilities are unique, those science themes will remain relevant through launch and operations and goals contained within these themes will continue to guide the design and implementation choices for the mission. More recently, it has also become clear that Webb will make major contributions to other areas of research, including dark energy, dark matter, active galactic nuclei, stellar populations, exoplanet characterization and Solar System objects. In this paper, we review the original four science themes and discuss how the scientific output of Webb will extend to these new areas of research. The James Webb Space Telescope was designed to meet science objectives in four themes: The End of the Dark Ages: First Light and Reionization, The Assembly of Galaxies, The Birth of Stars and Protoplanetary Systems, and Planetary Systems and the Origins of Life. More recently, it has become clear that Webb will also make major contributions to studies of dark energy, dark matter

  8. Astronaut James van Hoften working with Syncom IV-3 satellite

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Astronaut James D. van Hoften gives a shove to the previously troubled Syncom IV-3 communications satellite. Dr. van Hoften stands on a foot restraint/extension to the remote manipulator system (RMS) arm.

  9. Fine Guidance System for the James Webb Space Telescope Delivered

    NASA Video Gallery

    Video has music in the background but no dialogue. The second of four main instruments to fly aboard NASA's James Webb Space Telescope (Webb) has been delivered to NASA. The Fine Guidance Sensor (F...

  10. NCGE Special Award Presented to James A. Michener.

    ERIC Educational Resources Information Center

    Boehm, Richard G.; de Souza, Anthony R.

    1985-01-01

    In 1984 the National Council for Geographic Education presented James Michener with a special award for his "Outstanding Contributions to Geographic Education through the American Novel." Michener's acceptance speech is presented. (RM)

  11. 5. Historic American Buildings Survey James Rainey, Photographer May 16, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey James Rainey, Photographer May 16, 1936 LIVING? (MUSIC) ROOM FIREPLACE (LOOKING NORTH? SOUTH) - Thaddeus Burr Homestead, 491 Old Post Road, Fairfield, Fairfield County, CT

  12. 4. Historic American Buildings Survey James C. Massey, Photographer 1964 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey James C. Massey, Photographer 1964 MAIN (SOUTH) ENTRANCE (4x5' b&w film copy neg. from 35mm slide) - Albert F. Madlener House, 4 West Burton Place, Chicago, Cook County, IL

  13. 5. Historic American Buildings Survey James C. Massey, Photographer 1964 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey James C. Massey, Photographer 1964 MAIN (SOUTH) ENTRANCE DETAIL (4x5' b&w film copy neg. from 35mm slide) - Albert F. Madlener House, 4 West Burton Place, Chicago, Cook County, IL

  14. Astronaut James Newman with latch hook for tether device

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Astronaut James H. Newman, mission specialist, shows off a latch hook for a tether device used during the STS-51 extravehicular activity (EVA) on September 16, 1993. Newman, on Discovery's middeck, appears surrounded by sleep restraints.

  15. Plan of the entresol (third floor) of James H. Windrim ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Plan of the entresol (third floor) of James H. Windrim and George Summers’s competition design for the New Masonic Temple, Philadelphia, 1867 - Masonic Temple, 1 North Broad Street, Philadelphia, Philadelphia County, PA

  16. Young James Madison: His Character and Civic Values.

    ERIC Educational Resources Information Center

    Bennett, William J.

    1987-01-01

    Examines the life of James Madison, Founding Father and "theoretic statesman." Focuses specifically on Madison's education and character, his friendship with Thomas Jefferson, and his civic legacy: a selfless devotion to republican government and union. (JDH)

  17. Una mirada hacia el pasado -- El Telescopio Espacial James Webb

    NASA Video Gallery

    La NASA planea usar el nuevo Telescopio Espacial James Webb para mirar el pasado. Al observar la luz de las estrellas que se formaron al principio del universo, la NASA está a punto de arrojar nuev...

  18. 82. REGENTS' ROOM WEST WALL, WITH ORIGINAL CHAIRS BY JAMES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    82. REGENTS' ROOM WEST WALL, WITH ORIGINAL CHAIRS BY JAMES RENWICK, JR. MANTELPIECE AND MIRROR ARE NOT ORIGINAL TO THE ROOM. - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  19. Astronaut James D. van Hoften examines student experiment on Challenger

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut James D. van Hoften, 41-C mission specialist, holds an aluminum box full of honeybees. The experiment in earth orbit is duplicated with another colony of the bees on earth. This is an experiment submitted by student researchers.

  20. 6. Watchman Robert 'Jerry' Jones at Camp Dyer. Photographer James ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Watchman Robert 'Jerry' Jones at Camp Dyer. Photographer James Dix Schuyler, 1903. Source: Schuyler report. - Waddell Dam, On Agua Fria River, 35 miles northwest of Phoenix, Phoenix, Maricopa County, AZ

  1. 5. Historic American Buildings Survey James Rainey, Photographer May 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey James Rainey, Photographer May 10, 1936 GRINDING PLATFORM, VIEW OF INTERIOR LOOKING WEST - Old Town Mill, Mill Brook, near Mill Street, New London, New London County, CT

  2. STS-69 Mission Specialist James H. Newman in white room

    NASA Technical Reports Server (NTRS)

    1995-01-01

    At Launch Pad 39A, STS-69 Mission Specialist James H. Newman chats with white room closeout crew members Rene Arriens (far left), Travis Thompson and Bob Saulnier (right) prior to entering the Space Shuttle Endeavour.

  3. 2. Historic American Buildings Survey, James I. Campbell, Photographer February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, James I. Campbell, Photographer February 20, 1934 FRONT PORCH FROM EAST. - Nichols-Rice-Cherry House, Sam Houston Park (moved from San Jacinto Street), Houston, Harris County, TX

  4. 3. Historic American Buildings Survey, James I. Campbell, Photographer February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, James I. Campbell, Photographer February 20, 1934 SOUTH ELEVATION (FRONT). - Nichols-Rice-Cherry House, Sam Houston Park (moved from San Jacinto Street), Houston, Harris County, TX

  5. 5. Historic American Buildings Survey, James I. Campbell, Photographer February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, James I. Campbell, Photographer February 20, 1934 CLOSE-UP OF FRONT ENTRANCE. - Nichols-Rice-Cherry House, Sam Houston Park (moved from San Jacinto Street), Houston, Harris County, TX

  6. 4. Historic American Buildings Survey, James I. Campbell, Photographer February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, James I. Campbell, Photographer February 20, 1934 DETAIL OF FRONT ENTRANCE. - Nichols-Rice-Cherry House, Sam Houston Park (moved from San Jacinto Street), Houston, Harris County, TX

  7. 1. Historic American Buildings Survey, James I. Campbell, Photographer February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, James I. Campbell, Photographer February 20, 1934 VIEW FROM SOUTHEAST. - Nichols-Rice-Cherry House, Sam Houston Park (moved from San Jacinto Street), Houston, Harris County, TX

  8. 5. William Beardsley standing along canal section. Photographer James Dix ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. William Beardsley standing along canal section. Photographer James Dix Schuyler, 1903. Source: Schuyler report. - Waddell Dam, On Agua Fria River, 35 miles northwest of Phoenix, Phoenix, Maricopa County, AZ

  9. 1. Historic American Buildings Survey James O. Milmoe, Photographer Winter ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey James O. Milmoe, Photographer Winter 1979 GENERAL VIEW OF PLYMOUTH PLACE WITH CAPTIOL IN BACKGROUND - Plymouth Place, 1560-1572 Broadway, Denver, Denver County, CO

  10. James J. Jenkins (1923-2012).

    PubMed

    Foss, Donald J; Overmier, J Bruce

    2013-01-01

    Presents an obituary for James J. Jenkins. Jim Jenkins, fondly known as "J-cubed," was born on July 29, 1923, in St. Louis, Missouri. He attended William Jewell College but enlisted in the Army in 1942. He received a bachelor's degree in physics from the University of Chicago in 1944 as part of his training as a meteorologist. After serving in the South Pacific, he returned to William Jewell College, obtaining a bachelor's degree in psychology in 1947. Jenkins received a master's degree (1948) and a doctorate (1950) from the University of Minnesota under a giant in industrial psychology, Donald G. Paterson. He joined the Minnesota Psychology Department faculty upon graduation (turning down an offer from General Motors at triple the salary). Jenkins helped lead psychology's "cognitive revolution" from the second half of the 20th century into the present one. His work advanced multiple research areas: learning and memory, sentence processing, aphasia, speech perception, and perceptual organization. His remarkable combination of abilities led to nearly 200 scholarly publications and 500 conference and meeting presentations; multiple leadership positions, teaching awards, and professional accolades; and intense devotion from generations of students. PMID:23895612

  11. James Paget Henry--a retrospective.

    PubMed

    Meehan, J P; Meehan, W P

    1997-01-01

    James Paget Henry really began his productive research career at the outset of the second world war. His studies of acceleration and the anoxia of high altitude were supported by the development of then new techniques of measuring and recording critical physiologic parameters such as vascular pressures, respiratory functions and haemoglobin saturation. His inquisitive mind made productive use of the instruments that had to be made by skilled instrument makers working in university shops. Much of this instrumentation has now found its way into the clinical arena where it is now the main armamentarium of cardiac diagnostic and respiratory function laboratories. His work in the space program preceeded that of the Russians but did not get recognition until Sputnik awakened the world to the possibilities of space flight. His development of the concept of a cardiovascular basis for fluid volume control and the supportive investigative work undertaken constitute a milestone in the annals of experimental physiology. The chimpanzees used in Project Mercury were found to be hypertensive which was related to the method of capture used by the commercial suppliers. This lead Jim to study the effect of early experience on resting blood pressure, an effort that soon developed into provocative studies of the biological basis of the stress response. PMID:9401600

  12. James Moores Ball: Ophthalmologist, medical historian, bibliophile.

    PubMed

    Feibel, Robert M

    2016-08-01

    James Moores Ball (1862-1929) was an ophthalmologist in St. Louis, Missouri, who excelled as a medical historian and collector of rare and historic books about the history of anatomy. During his lifetime, he was best known as the author of a comprehensive, authoritative, and popular textbook titled Modern Ophthalmology First published in 1904, there were five further editions. Ball was very interested in the history of anatomy and wrote two books on this subject, the first being a biography of Andreas Vesalius, one of the earliest in English, and the second a history of the resurrection men or grave robbers who sold corpses to professors of anatomy and surgery for teaching purposes. His legacy today is the 470 volumes of his personal library, which are now in the Archives and Rare Books department of the Becker Medical Library of the Washington University School of Medicine. These texts are one of their major collections, concentrating on the history of anatomy, beginning with a first edition of Vesalius's De Humani Corporis Fabrica and holding many important and beautiful landmark volumes of anatomical atlases. PMID:27316691

  13. Science with the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2010-01-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these for science themes, JWST will be a large (6.6m) cold (50K) telescope launched to the second Earth-Sun Lagrange point in 2014. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA.

  14. Science with the James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Gardner, J. P.; JWST Science Working Group

    2005-12-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these for science themes, JWST will be a large (6.5m) cold (50K) telescope launched to the second Earth-Sun Lagrange point early in the next decade. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA. JWST will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 27 microns.

  15. Microshutter Arrays for James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Li, Mary J.; Acuna, Nadine; Beamesderfer, Michael; Ewin, Audrey; Fettig, Rainer; Franz, Dave; Hess, Larry; Hu, Ron; Kelly, Dan; King, Todd

    2004-01-01

    Two-dimensional MEMS microshutter arrays are being developed at NASA Goddard Space Flight Center for use in the near-infrared region on the James Webb Space Telescope (JWST). The microshutter arrays are designed for the selective transmission of light with high efficiency and high contrast. The JWST environment requires cryogenic operation at 35K. Microshutter arrays are fabricated out of silicon-oxide-insulated (SOI) silicon wafers. Arrays are close-packed silicon nitride membranes with a pixel size of 100x200 p. Individual shutters are patterned with a torsion flexure permitting shutters to open 90 degrees with a minimized mechanical stress concentration. The mechanical shutter arrays are fabricated using MEMS technologies. The processing includes a multi- layer metal deposition and patterning of shutter electrodes and magnetic pads, reactive ion etching (NE) of the front side to form shutters out of the nitride membrane, an anisotropic back-etch for wafer thinning, followed by a deep RIE (DRIE) back-etch down to the nitride shutter membrane to form W e s and relieve shutters from the silicon substrate. An additional metal deposition and patterning is used to form back electrodes. Shutters are actuated using a magnetic force and latched using an electrostatic force. . . . KEYWORDS: microshutter, MEMS, RIE, DRIE, micro-optics, near inbred, space telescope

  16. STS-109 Crew Interviews: James H. Newman

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-109 Mission Specialist James H. Newman is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut, his career path, and his most memorable experiences. He gives details on the mission's goals and objectives, which focus on the refurbishing of the Hubble Space Telescope, and his role in the mission. He provides a brief background on the Hubble Space Telescope, and explains the plans for the rendezvous of the Columbia Orbiter with the Hubble Space Telescope. He provides details and timelines for each of the planned Extravehicular Activities (EVAs), which include replacing the solar arrays, changing the Power Control Unit, installing the Advanced Camera for Surveys (ACS), and installing a new Cryocooler for the Near Infrared Camera and Multi-Object Spectrometer (NICMOS). He gives further explanation of each of these pieces of equipment. He also describes the break-out plan in place for these spacewalks. The interview ends with Newman explaining the details of a late addition to the mission's tasks, which is to replace a reaction wheel on the Hubble Space Telescope.

  17. James L. Outtz (1947-2016).

    PubMed

    Zedeck, Sheldon; Cascio, Wayne

    2016-09-01

    This article memorializes James L. Outtz, who passed away March 26, 2016. For more than 40 years, Outtz was a leading researcher, practitioner, and consultant in the areas of hiring and promotion, employment discrimination, selection-test design and implementation, and legal issues pertaining to employment. He worked tirelessly to enhance opportunities for workforce diversity through greater inclusion of minorities and women. Another important focus was on strategies to minimize adverse impact through alternative approaches to selection. His work significantly influenced best practices in equal employment opportunity, and he was a highly sought-after legal-compliance consultant and testifying expert, advisor to courts, and participant on consent decrees with experts and lawyers from all sides of an issue. His efforts involved some of the most prominent corporations in America and most visible public-sector jurisdictions. In his final 2 years, he became president-elect of the Society for Industrial and Organizational Psychology (SIOP). (PsycINFO Database Record PMID:27571534

  18. Building the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2012-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes. It will be a large (6.6m) cold (50K) telescope launched into orbit around the second Earth-Sun Lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. JWST will make progress In almost every area of astronomy, from the first galaxies to form in the early universe to exoplanets and Solar System objects. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Near-Infrared Imager and Slitless Spectrograph will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. The observatory Is confirmed for launch in 2018; the design is complete and it is in its construction phase. Innovations that make JWST possible include large-area low-noise infrared detectors, cryogenic ASICs, a MEMS micro-shutter array providing multi-object spectroscopy, a non-redundant mask for interferometric coronagraphy and diffraction-limited segmented beryllium mirrors with active wavefront sensing and control. Recent progress includes the completion of the mirrors, the delivery of the first flight instruments and the start of the integration and test phase.

  19. Science with the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2012-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes. It will be a large (6.6m) cold (50K) telescope launched into orbit around the second Earth-Sun lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. The science goals for JWST include the formation of the first stars and galaxies in the early universe; the chemical, morphological and dynamical buildup of galaxies and the formation of stars and planetary systems. Recently, the goals have expanded to include studies of dark energy, dark matter, active galactic nuclei, exoplanets and Solar System objects. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Near-Infrared Imager and Slitiess Spectrograph will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. The observatory is confirmed for launch in 2018; the design is complete and it is in its construction phase. Recent progress includes the completion of the mirrors, the delivery of the first flight instrument(s) and the start of the integration and test phase.

  20. James Webb Space Telescope Orbit Determination Analysis

    NASA Technical Reports Server (NTRS)

    Yoon, Sungpil; Rosales, Jose; Richon, Karen

    2014-01-01

    The James Webb Space Telescope (JWST) is designed to study and answer fundamental astrophysical questions from an orbit about the Sun-EarthMoon L2 libration point, 1.5 million km away from Earth. Three mid-course correction (MCC) maneuvers during launch and early orbit phase and transfer orbit phase are required for the spacecraft to reach L2. These three MCC maneuvers are MCC-1a at Launch+12 hours, MCC-1b at L+2.5 days and MCC-2 at L+30 days. Accurate orbit determination (OD) solutions are needed to support MCC maneuver planning. A preliminary analysis shows that OD performance with the given assumptions is adequate to support MCC maneuver planning. During the nominal science operations phase, the mission requires better than 2 cmsec velocity estimation performance to support stationkeeping maneuver planning. The major challenge to accurate JWST OD during the nominal science phase results from the unusually large solar radiation pressure force acting on the huge sunshield. Other challenges are stationkeeping maneuvers at 21-day intervals to keep JWST in orbit around L2, frequent attitude reorientations to align the JWST telescope with its targets and frequent maneuvers to unload momentum accumulated in the reaction wheels. Monte Carlo analysis shows that the proposed OD approach can produce solutions that meet the mission requirements.

  1. James Webb Space Telescope Orbit Determination Analysis

    NASA Technical Reports Server (NTRS)

    Yoon, Sungpil; Rosales, Jose; Richon, Karen

    2014-01-01

    The James Webb Space Telescope (JWST) is designed to study and answer fundamental astrophysical questions from an orbit about the Sun-Earth/Moon L2 libration point, 1.5 million km away from Earth. This paper describes the results of an orbit determination (OD) analysis of the JWST mission emphasizing the challenges specific to this mission in various mission phases. Three mid-course correction (MCC) maneuvers during launch and early orbit phase and transfer orbit phase are required for the spacecraft to reach L2. These three MCC maneuvers are MCC-1a at Launch+12 hours, MCC-1b at L+2.5 days and MCC-2 at L+30 days. Accurate OD solutions are needed to support MCC maneuver planning. A preliminary analysis shows that OD performance with the given assumptions is adequate to support MCC maneuver planning. During the nominal science operations phase, the mission requires better than 2 cm/sec velocity estimation performance to support stationkeeping maneuver planning. The major challenge to accurate JWST OD during the nominal science phase results from the unusually large solar radiation pressure force acting on the huge sunshield. Other challenges are stationkeeping maneuvers at 21-day intervals to keep JWST in orbit around L2, frequent attitude reorientations to align the JWST telescope with its targets and frequent maneuvers to unload momentum accumulated in the reaction wheels. Monte Carlo analysis shows that the proposed OD approach can produce solutions that meet the mission requirements.

  2. A Conversation with James J. Morgan

    NASA Astrophysics Data System (ADS)

    Morgan, James J.; Newman, Dianne K.

    2015-05-01

    In conversation with professor Dianne Newman, Caltech geobiologist, James "Jim" J. Morgan recalls his early days in Ireland and New York City, education in parochial and public schools, and introduction to science in Cardinal Hayes High School, Bronx. In 1950, Jim entered Manhattan College, where he elected study of civil engineering, in particular water quality. Donald O'Connor motivated Jim's future study of O2 in rivers at Michigan, where in his MS work he learned to model O2 dynamics of rivers. As an engineering instructor at Illinois, Jim worked on rivers polluted by synthetic detergents. He chose to focus on chemical studies, seeing it as crucial for the environment. Jim enrolled for PhD studies with Werner Stumm at Harvard, who mentored his research in chemistry of particle coagulation and oxidation processes of Mn(II) and (IV). In succeeding decades, until retirement in 2000, Jim's teaching and research centered on aquatic chemistry; major themes comprised rates of abiotic manganese oxidation on particle surfaces and flocculation of natural water particles, and chemical speciation proved the key.

  3. James F. T. Bugental (1915-2008).

    PubMed

    Schneider, Kirk J; Greening, Tom

    2009-01-01

    James F. T. Bugental died peacefully at age 92 at his Petaluma, California, home on September 18, 2008. Jim was a leading psychotherapist and a founding father, with Abraham Maslow and others, of humanistic psychology, or the "third force" (in contrast to psychoanalysis and behaviorism). Jim was also the creator, along with Rollo May, of existential-humanistic psychotherapy. Jim was born in Fort Wayne, Indiana, on Christmas Day in 1915. Jim earned his doctorate in 1948 from Ohio State University, where he was influenced by Victor Raimy and George Kelly. After a brief time on the University of California, Los Angeles (UCLA) faculty in psychology, Jim resigned in 1953 to found the first group practice of psychotherapy, Psychological Service Associates, with Alvin Lasko. With Abraham Maslow and others, Jim was a cofounder of the Journal of Humanistic Psychology (JHP) and the Association for Humanistic Psychology in 1961. Jim also wrote many books on the topic of psychotherapy during his lifetime. Jim was a great and bold spirit--his many writings and teachings are cherished today widely, and the field of psychology is much richer for his efforts. PMID:19203148

  4. Science with the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2006-01-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dustenshrouded protostars, to the genesis of planetary systems. Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these for science themes, JWST will be a large (6.5m) cold (50K) telescope with four instruments, capable of imaging and spectroscopy from 0.6 to 27 microns wavelength.

  5. SirT1 in muscle physiology and disease: lessons from mouse models

    PubMed Central

    Vinciguerra, Manlio; Fulco, Marcella; Ladurner, Andreas; Sartorelli, Vittorio; Rosenthal, Nadia

    2010-01-01

    Sirtuin 1 (SirT1) is the largest of the seven members of the sirtuin family of class III nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases, whose activation is beneficial for metabolic, neurodegenerative, inflammatory and neoplastic diseases, and augments life span in model organisms (Finkel et al., 2009; Lavu et al., 2008). In vitro studies show that SirT1 protects genome integrity and is involved in circadian physiological rhythms (Asher et al., 2008; Nakahata et al., 2008; Oberdoerffer et al., 2008). In the last few years, a fundamental role for SirT1 in the metabolism and differentiation of skeletal muscle cells has been uncovered (Fulco et al., 2003), and the use of specific transgenic or knockout SirT1 mouse models implicates it in the protection of heart muscle from oxidative and hypertrophic stresses (Alcendor et al., 2007). In this Perspective, we review the recent exciting findings that have established a key role for the ’longevity’ protein SirT1 in skeletal and heart muscle physiology and disease. Furthermore, given the multiple biological functions of SirT1, we discuss the unique opportunities that SirT1 mouse models can offer to improve our integrated understanding of the metabolism, as well as the regeneration and aging-associated changes in the circadian function, of skeletal and heart muscle. PMID:20354108

  6. Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes

    PubMed Central

    Sanders, Brandi D.; Zhao, Kehao; Slama, James T.; Marmorstein, Ronen

    2009-01-01

    SUMMARY The Sir2 family of proteins are broadly conserved NAD+-dependant deacetylases that are implicated in diverse biological processes including DNA regulation, metabolism and longevity. Sir2 proteins are regulated in part by the cellular concentrations of a noncompetitive inhibitor, nicotinamide, that reacts with a Sir2 reaction intermediate via a base exchange reaction to reform NAD+ at the expense of deacetylation. To gain a mechanistic understanding of nicotinamide inhibition in Sir2 enzymes, we captured the structure of nicotinamide bound to a Sir2 homologue, yeast Hst2, in complex with its acetyl-lysine 16 histone H4 substrate and a reaction intermediate analog, ADP-HPD. Together with related biochemical studies and structures, we identify a nicotinamide inhibition and base exchange site that is distinct from the so-called “C pocket” binding site for the nicotinamide group of NAD+. These results provide insights into the Sir2 mechanism of nicotinamide inhibition and have important implications for the development of Sir2-specific effectors. PMID:17289592

  7. Structural Integrity Recording System (SIR) for U.S. Army AH-1G Helicopters

    NASA Astrophysics Data System (ADS)

    Farrell, T. G.; Johnson, R. B.; Tyler, M. C.

    1981-03-01

    A Structural Integrity Recording System (SIRS) was designed and developed to track the fatigue damage accumulation on 10 critical helicopter components for the subsequent timely replacement of such components for safer and more economical helicopter operation. SIRS comprises three discrete but interrelated subsystems: an airborne microprocessor-based recorder, a portable flight-line data retrieval unit, and a software system. The validation of SIRS, initially configured for the AH-1G helicopter, consisted of two phases. Phase I (Development Test and Evaluation - DT E) covered the design, fabrication, laboratory qualification testing, reliability analysis, and flight-testing of the prototype SIRS recorder. Phase II (Initial Operational Test and Evaluation - IOT E) covered the evaluation of the entire system operation and the resultant data acquired during a 3-month recording period with five AH-1G's, each equipped with a SIRS recorder. As the documentation of both DT E and IOT E, this report describes the characteristics and functions of the entire system and details the successful performance of the SIRS recorder in the laboratory qualification testing and the flight environment. The SIRS recorder performed as designed, operated reliably, and yielded valid data.

  8. Relationships between rDNA, Nop1 and Sir complex in biotechnologically relevant distillery yeasts.

    PubMed

    Adamczyk, Jagoda; Deregowska, Anna; Potocki, Leszek; Kuna, Ewelina; Kaplan, Jakub; Pabian, Sylwia; Kwiatkowska, Aleksandra; Lewinska, Anna; Wnuk, Maciej

    2016-09-01

    Distillery yeasts are poorly characterized physiological group among the Saccharomyces sensu stricto complex. As industrial yeasts are under constant environmental stress during fermentation processes and the nucleolus is a stress sensor, in the present study, nucleolus-related parameters were evaluated in 22 commercially available distillery yeast strains. Distillery yeasts were found to be a heterogeneous group with a variable content and length of rDNA and degree of nucleolus fragmentation. The levels of rDNA were negatively correlated with Nop1 (r = -0.59, p = 0.0038). Moreover, the protein levels of Sir transcriptional silencing complex and longevity regulators, namely Sir1, Sir2, Sir3 and Fob1, were studied and negative correlations between Sir2 and Nop1 (r = -0.45, p = 0.0332), and between Sir2 and Fob1 (r = -0.49, p = 0.0211) were revealed. In general, S. paradoxus group of distillery yeasts with higher rDNA pools and Sir2 level than S. bayanus group was found to be more tolerant to fermentation-associated stress stimuli, namely mild cold/heat stresses and KCl treatment. We postulate that rDNA state may be considered as a novel factor that may modulate a biotechnological process. PMID:27329282

  9. Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes

    SciTech Connect

    Sanders, B.; Zhao, K; Slama, J; Marmorstein, R

    2007-01-01

    The Sir2 family of proteins consists of broadly conserved NAD+-dependent deacetylases that are implicated in diverse biological processes, including DNA regulation, metabolism, and longevity. Sir2 proteins are regulated in part by the cellular concentrations of a noncompetitive inhibitor, nicotinamide, that reacts with a Sir2 reaction intermediate via a base-exchange reaction to reform NAD+ at the expense of deacetylation. To gain a mechanistic understanding of nicotinamide inhibition in Sir2 enzymes, we captured the structure of nicotinamide bound to a Sir2 homolog, yeast Hst2, in complex with its acetyl-lysine 16 histone H4 substrate and a reaction intermediate analog, ADP-HPD. Together with related biochemical studies and structures, we identify a nicotinamide inhibition and base-exchange site that is distinct from the so-called 'C pocket' binding site for the nicotinamide group of NAD+. These results provide insights into the Sir2 mechanism of nicotinamide inhibition and have important implications for the development of Sir2-specific effectors.

  10. SirR, a novel iron-dependent repressor in Staphylococcus epidermidis.

    PubMed

    Hill, P J; Cockayne, A; Landers, P; Morrissey, J A; Sims, C M; Williams, P

    1998-09-01

    In Staphylococcus epidermidis and Staphylococcus aureus, a number of cell wall- and cytoplasmic membrane-associated lipoproteins are induced in response to iron starvation. To gain insights into the molecular basis of iron-dependent gene regulation in the staphylococci, we sequenced the DNA upstream of the 3-kb S. epidermidis sitABC operon, which Northern blot analysis indicates is transcriptionally regulated by the growth medium iron content. We identified two DNA sequences which are homologous to elements of the Corynebacterium diphtheriae DtxR regulon, which controls, in response to iron stress, for example, production of diphtheria toxin, siderophore, and a heme oxygenase. Upstream of the sitABC operon and divergently transcribed lies a 645-bp open reading frame (ORF), which codes for a polypeptide of approximately 25 kDa with homology to the DtxR family of metal-dependent repressor proteins. This ORF has been designated SirR (staphylococcal iron regulator repressor). Within the sitABC promoter/operator region, we also located a region of dyad symmetry overlapping the transcriptional start of sitABC which shows high homology to the DtxR operator consensus sequence, suggesting that this region, termed the Sir box, is the SirR-binding site. The SirR protein was overexpressed, purified, and used in DNA mobility shift assays; SirR retarded the migration of a synthetic oligonucleotide based on the Sir box in a metal (Fe2+ or Mn2+)-dependent manner, providing confirmatory evidence that this motif is the SirR-binding site. Furthermore, Southern blot analysis of staphylococcal chromosomal DNA with the synthetic Sir box as a probe confirmed that there are at least five Sir boxes in the S. epidermidis genome and at least three in the genome of S. aureus, suggesting that SirR controls the expression of multiple target genes. Using a monospecific polyclonal antibody raised against SirR to probe Western blots of whole-cell lysates of S. aureus, S. carnosus, S. epidermidis

  11. Shuttle Imaging Radar B (SIR-B) Weddell Sea ice observations - A comparison of SIR-B and scanning multichannel microwave radiometer ice concentrations

    NASA Technical Reports Server (NTRS)

    Martin, Seelye; Holt, Benjamin; Cavalieri, Donald J.; Squire, Vernon

    1987-01-01

    Ice concentrations over the Weddell Sea were studied using SIR-B data obtained during the October 1984 mission, with special attention given to the effect of ocean waves on the radar return at the ice edge. Sea ice concentrations were derived from the SIR-B data using two image processing methods: the classification scheme at JPL and the manual classification method at Scott Polar Research Institute (SPRI), England. The SIR ice concentrations were compared with coincident concentrations from the Nimbus-7 SMMR. For concentrations greater than 40 percent, which was the smallest concentration observed jointly by SIR-B and the SMMR, the mean difference between the two data sets for 12 points was 2 percent. A comparison between the JPL and the SPRI SIR-B algorithms showed that the algorithms agree to within 1 percent in the interior ice pack, but the JPL algorithm gives slightly greater concentrations at the ice edge (due to the fact that the algorithm is affected by the wind waves in these areas).

  12. Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme

    PubMed Central

    Manning, Benjamin J.; Peterson, Craig L.

    2014-01-01

    Heterochromatin is a specialized chromatin structure that is central to eukaryotic transcriptional regulation and genome stability. Despite its globally repressive role, heterochromatin must also be dynamic, allowing for its repair and replication. In budding yeast, heterochromatin formation requires silent information regulators (Sirs) Sir2p, Sir3p, and Sir4p, and these Sir proteins create specialized chromatin structures at telomeres and silent mating-type loci. Previously, we found that the SWI/SNF chromatin remodeling enzyme can catalyze the ATP-dependent eviction of Sir3p from recombinant nucleosomal arrays, and this activity enhances early steps of recombinational repair in vitro. Here, we show that the ATPase subunit of SWI/SNF, Swi2p/Snf2p, interacts with the heterochromatin structural protein Sir3p. Two interaction surfaces are defined, including an interaction between the ATPase domain of Swi2p and the nucleosome binding, Bromo-Adjacent-Homology domain of Sir3p. A SWI/SNF complex harboring a Swi2p subunit that lacks this Sir3p interaction surface is unable to evict Sir3p from nucleosomes, even though its ATPase and remodeling activities are intact. In addition, we find that the interaction between Swi2p and Sir3p is key for SWI/SNF to promote resistance to replication stress in vivo and for establishment of heterochromatin at telomeres. PMID:25453095

  13. Shuttle imaging radar-B (SIR-B) data analysis for identifying rainfall event occurrence and intensity

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The utility of SIR-B data were evaluated for the detection and measurement of rainfall events, and applications of SIR-B data were developed to the improvement of existing rainfall models. During the SIR-B mission, EarthSat monitored rainfall events occurring within the conterminous United States. The GOES scenes form showed rainfall activity within the conterminous U.S. during the SIR-B mission. Swaths of the actual SIR-B data taken were plotted onto the GOES satellite scenes most closely representing the time of the Shuttle overpass. The JPL provided EarthSat with available SIR-B imagery in paper print form representing the appropriate requested data takes. EarthSat identified the collateral data required for site characterization during subsequent SIR-B contracts with JPL.

  14. Progress on the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Mather, John C.

    2009-01-01

    I will describe the scientific program anticipated for the James Webb Space Telescope and the progress in its construction. When the JWST was conceived in 1995 it was expected to make its greatest contributions in the study of the first objects to form after the Big Bang, in the evolution of galaxies, and in the formation and evolution of stars and planetary systems. Since then, the age-distance-redshift relation has become clear with the precise measurement of the Hubble constant, the discovery of the accelerating universe, and the remarkable agreement of CMBR calculations with direct measurements of the large-scale structure. So what is left and what has changed? Galaxy formation and growth is still mysterious, star formation is still hidden, the dark matter and dark energy are still unobservable, and the tools at hand may or may not help enough. But the JWST, as a general-purpose observatory, will be available for imaginative use, and is just what Simon White's polemic seems to request. As an example, the JWST should be quite capable of observing transiting exoplanets with remarkable precision, even though there was no requirement to do so, and its coronagraphs will be very good even without a monolithic primary mirror. The JWST mission has now been officially approved by NASA and is in the Federal budget. It is planned for launch in 2014. Flight instruments will begin to arrive at Goddard in mid-2010, and the first flight mirror segments have already passed their first cryogenic tests. The flight detectors have been selected and have remarkable performance; for example, the near IR detectors have dark currents of the order of 10 electrons per pixel per hour.

  15. Science with the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2011-01-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these for science themes, JWST will be a large (6.6m) cold (50K) telescope in orbit around the second Earth-Sun Lagrange point. It is the successor to the Hubble and Spitzer Space Telescopes, and is a partnership of NASA, ESA and CSA. JWST will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. I will conclude the talk with a description of recent technical progress in the construction of the observatory.

  16. Science with the James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Gardner, Jonathan P.

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these four science themes, JWST will be a large (6.5m) cold (50K) telescope launched to the second Earth-Sun Lagrange point early in the next decade. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA. JWST will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 27 microns. The scientific investigations described here define the measurement capabilities of the telescope, but they do not imply that those particular observations will be made. JWST is a facility-class mission, so most of the observing time will be allocated to investigators from the international astronomical community through competitively-selected proposals.

  17. [James Parkinson (1755-1824) revisited].

    PubMed

    Poirier, Jacques

    2013-03-01

    The name of Parkinson is universally famous because of the eponymous disease. But as a man, James Parkinson (1755-1824), is poorly known. He was born, married and passed away in his St-Leonard parish in Shoreditch (London). After having studied Latin, Greek, natural philosophy, and stenography (shorthand), which he considered as the basic tools of any doctor, he studied for six months at the London Hospital Medical College, and served his apprenticeship as an apothecary-surgeon with his father for six years. Then he was qualified as a surgeon in 1784 at the age of 29 years. His activity has been deployed in three areas: 1) medicine, 2) political activism and social reformism, 3) paleontology and oryctology. As a physician, Parkinson has published several books, the most important concerned paralysis agitans (future Parkinson's disease), gout, complications of lightning (future Lichtenberg figures and keraunoparalysis), acute appendicitis (with his son John Parkinson) and hernias (diagnosis, development, dangers of hernia ruptures, and design of a simple truss). Its ideological and political commitment was manifested by joining two secret societies and publishing numerous pamphlets, many of which are signed by the pseudonym Old Hubert; he campaigned for a better representation of the people in Parliament, for greater social justice, for the defense and recognition of the rights of the poor, the insane, the children, and against children abuse. He published a small compendium of chemistry, he was one of the thirteen members who create the British Geological Society and is recognized as one of the founders of paleontology; as was Georges Cuvier (1769-1832), he remained a strong supporter of creationism and catastrophism. Distinguished oryctologist, he gave his name to several fossils, mainly molluscs. PMID:23508322

  18. Science with the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2006-01-01

    The scientific capabilities of the James Webb Space Telescope (JWST) fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. To enable these for science themes, JWST will be a large (6.5m) cold (50K) telescope launched to the second Earth-Sun Lagrange point early in the next decade. It is the successor to the Hubble Space Telescope, and is a partnership of NASA, ESA and CSA. JWST will have three instruments: The Near-Infrared Camera, and the Near-Infrared multi-object Spectrograph will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 27 microns. I review the status and capabilities of the observatory and instruments in the context of the major scientific goals.

  19. Analysis of Sir2p domains required for rDNA and telomeric silencing in Saccharomyces cerevisiae.

    PubMed Central

    Cockell, M M; Perrod, S; Gasser, S M

    2000-01-01

    Silent information regulator (Sir) 2 is a limiting component of the Sir2/3/4 complex, which represses transcription at subtelomeric and HM loci. Sir2p also acts independently of Sir3p and Sir4p to influence chromatin organization in the rDNA locus. Deleted and mutated forms of Sir2p have been tested for their ability to complement and/or to disrupt silencing. The highly conserved C-terminal domain of Sir2p (aa 199-562) is insufficient to restore repression at either telomeric or rDNA reporters in a sir2Delta background and fails to nucleate silencing when targeted to an appropriate reporter gene. However, its expression in an otherwise wild-type strain disrupts telomeric repression. Similarly, a point mutation (P394L) within this conserved core inactivates the full-length protein but renders it dominant negative for all types of silencing. Deletion of aa 1-198 from Sir2(394L) eliminates its dominant negative effect. Thus we define two distinct functional domains in Sir2p, both essential for telomeric and rDNA repression: the conserved core domain found within aa 199-562 and a second domain that encompasses aa 94-198. Immunolocalization and two-hybrid studies show that aa 94-198 are required for the binding of Sir2p to Sir4p and for the targeting of Sir2p to the nucleolus through another ligand. The globular core domain provides an essential silencing function distinct from that of targeting or Sir complex formation that may reflect its reported mono-ADP-ribosyl transferase activity. PMID:10757754

  20. An overview of the National Space Science data Center Standard Information Retrieval System (SIRS)

    NASA Technical Reports Server (NTRS)

    Shapiro, A.; Blecher, S.; Verson, E. E.; King, M. L. (Editor)

    1974-01-01

    A general overview is given of the National Space Science Data Center (NSSDC) Standard Information Retrieval System. A description, in general terms, the information system that contains the data files and the software system that processes and manipulates the files maintained at the Data Center. Emphasis is placed on providing users with an overview of the capabilities and uses of the NSSDC Standard Information Retrieval System (SIRS). Examples given are taken from the files at the Data Center. Detailed information about NSSDC data files is documented in a set of File Users Guides, with one user's guide prepared for each file processed by SIRS. Detailed information about SIRS is presented in the SIRS Users Guide.

  1. Sir Paul McCartney Wake-up Song and Greeting

    NASA Video Gallery

    Paul McCartney and Beatles favorite "Good Day Sunshine" greet the Atlantis crew of Chris Ferguson, Doug Hurley, Sandy Magnus and Rex Walheim first thing on Flight Day 8. Sir Paul and the Beatles’...

  2. Readings that Made a Difference: Cushing's "The Life of Sir William Osler."

    ERIC Educational Resources Information Center

    Durrell, Donald D.

    1979-01-01

    Describes the impact on the author of reading Harvey Cushing's "The Life of Sir William Osler," a biography of the leading American medical educator in the late nineteenth century, which stressed his reading interests. (DD)

  3. The independent spreaders involved SIR Rumor model in complex networks

    NASA Astrophysics Data System (ADS)

    Qian, Zhen; Tang, Shaoting; Zhang, Xiao; Zheng, Zhiming

    2015-07-01

    Recent studies of rumor or information diffusion process in complex networks show that in contrast to traditional comprehension, individuals who participate in rumor spreading within one network do not always get the rumor from their neighbors. They can obtain the rumor from different sources like online social networks and then publish it on their personal sites. In our paper, we discuss this phenomenon in complex networks by adopting the concept of independent spreaders. Rather than getting the rumor from neighbors, independent spreaders learn it from other channels. We further develop the classic "ignorant-spreaders-stiflers" or SIR model of rumor diffusion process in complex networks. A steady-state analysis is conducted to investigate the final spectrum of the rumor spreading under various spreading rate, stifling rate, density of independent spreaders and average degree of the network. Results show that independent spreaders effectively enhance the rumor diffusion process, by delivering the rumor to regions far away from the current rumor infected regions. And though the rumor spreading process in SF networks is faster than that in ER networks, the final size of rumor spreading in ER networks is larger than that in SF networks.

  4. [Sir Arthur Conan Doyle, Sherlock Holmes and infectious diseases].

    PubMed

    Ledermann D, Walter

    2010-10-01

    Besides a pleasant author of best sellers, Sir Arthur Conan Doyle was a medical doctor, writing excellent short stories about the exercise of his profession in England. However, even he mentions The British Medical Journal and The Lancet in the Sherlock Holmes's stories, when in the plot introduces infectious diseases, Conan Doyle ignores important discoveries in the field of tetanus. Anyway, the appearing of infectious diseases in the adventures of the detective are rare: one mention of tetanus, another of leprosy and- the most analyzed in medical literature a case of murder by inoculation of bacteria, probably the agent of melioidosis. Also he makes his hero discovers the toxic actions of a medusa and a transplant of solid organ. Little for a physician and less for an author who also wrote science fiction: it seems that the history of the great medical discoveries at the end of nineteenth century and beginning of the twentieth has passed by his side.., and he just couldn't see it. PMID:21186510

  5. The functional importance of telomere clustering: Global changes in gene expression result from SIR factor dispersion

    PubMed Central

    Taddei, Angela; Van Houwe, Griet; Nagai, Shigeki; Erb, Ionas; van Nimwegen, Erik; Gasser, Susan M.

    2009-01-01

    Budding yeast telomeres and cryptic mating-type loci are enriched at the nuclear envelope, forming foci that sequester silent information regulators (SIR factors), much as heterochromatic chromocenters in higher eukaryotes sequester HP1. Here we examine the impact of such subcompartments for regulating transcription genome-wide. We show that the efficiency of subtelomeric reporter gene repression depends not only on the strength of SIR factor recruitment by cis-acting elements, but also on the accumulation of SIRs in such perinuclear foci. To monitor the effects of disrupting this subnuclear compartment, we performed microarray analyses under conditions that eliminate telomere anchoring, while preserving SIR complex integrity. We found 60 genes reproducibly misregulated. Among those with increased expression, 22% were within 20 kb of a telomere, confirming that the nuclear envelope (NE) association of telomeres helps repress natural subtelomeric genes. In contrast, loci that were down-regulated were distributed over all chromosomes. Half of this ectopic repression was SIR complex dependent. We conclude that released SIR factors can promiscuously repress transcription at nontelomeric genes despite the presence of “anti-silencing” mechanisms. Bioinformatic analysis revealed that promoters bearing the PAC (RNA Polymerase A and C promoters) or Abf1 binding consenses are consistently down-regulated by mislocalization of SIR factors. Thus, the normal telomeric sequestration of SIRs both favors subtelomeric repression and prevents promiscuous effects at a distinct subset of promoters. This demonstrates that patterns of gene expression can be regulated by changing the spatial distribution of repetitive DNA sequences that bind repressive factors. PMID:19179643

  6. Nonlinear Stability of a SIRS Epidemic Model with Convex Incidence Rate

    NASA Astrophysics Data System (ADS)

    Buonomo, B.; Rionero, S.

    2010-09-01

    We study an epidemic model for infections with non permanent acquired immunity (SIRS). The incidence rate is assumed to be convex respect to the infective class. By using a peculiar Lyapunov function, we obtain necessary and sufficient conditions for the local nonlinear stability of equilibria. Conditions ensuring the global stability of the endemic equilibrium are also obtained. Our procedure allows to enlarge the class of incidence rates ensuring the Lyapunov nonlinear stability of the endemic equilibrium for SIRS models.

  7. Analysis of coregistered Landsat, Seasat and SIR-A images of varied terrain types

    NASA Astrophysics Data System (ADS)

    Rebillard, Philippe; Evans, Diane

    1983-04-01

    Multisensor image data (SIR-A, Seasat SAR and Landsat MSS) over areas in northern Algeria and eastern Utah have been coregistered in order to assess the complementary effects of the orbital sensors for geologic mapping in two very different terrains. This first attempt at registering such a data set shows that the radar backscatter information provided by the SIR-A image increases the classification accuracy of several geologic units over the Landsat image alone, and over combined Landsat and Seasat images.

  8. Geologic mapping of Indonesian rain forest with analysis of multiple SIR-B incidence angles

    NASA Technical Reports Server (NTRS)

    Ford, J. P.; Sabins, F. F., Jr.; Asmoro, P., Jr.

    1984-01-01

    The discrimination and mapping capabilities are to be evaluated for shuttle imaging radar-B (SIR-B) images of geologic features in Indonesia that are covered by equatorial rain forest canopy. The SIR-B backscatter from the rain forest at L-band is to be compared to backscatter acquired by the SEASAT scatterometer system at Ku-band ever corresponding areas. The approach for data acquisition, handling, and analysis and the expected results of the investigation are discussed.

  9. Sir2 Paralogues Cooperate to Regulate Virulence Genes and Antigenic Variation in Plasmodium falciparum

    PubMed Central

    Duraisingh, Manoj T; Voss, Till S; Ralph, Stuart A; Hommel, Mirja; Duffy, Michael F; da Silva, Liliana Mancio; Scherf, Artur; Ivens, Alasdair; Speed, Terence P; Beeson, James G; Cowman, Alan F

    2009-01-01

    Cytoadherance of Plasmodium falciparum-infected erythrocytes in the brain, organs and peripheral microvasculature is linked to morbidity and mortality associated with severe malaria. Parasite-derived P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) molecules displayed on the erythrocyte surface are responsible for cytoadherance and undergo antigenic variation in the course of an infection. Antigenic variation of PfEMP1 is achieved by in situ switching and mutually exclusive transcription of the var gene family, a process that is controlled by epigenetic mechanisms. Here we report characterisation of the P. falciparum silent information regulator's A and B (PfSir2A and PfSir2B) and their involvement in mutual exclusion and silencing of the var gene repertoire. Analysis of P. falciparum parasites lacking either PfSir2A or PfSir2B shows that these NAD+-dependent histone deacetylases are required for silencing of different var gene subsets classified by their conserved promoter type. We also demonstrate that in the absence of either of these molecules mutually exclusive expression of var genes breaks down. We show that var gene silencing originates within the promoter and PfSir2 paralogues are involved in cis spreading of silenced chromatin into adjacent regions. Furthermore, parasites lacking PfSir2A but not PfSir2B have considerably longer telomeric repeats, demonstrating a role for this molecule in telomeric end protection. This work highlights the pivotal but distinct role for both PfSir2 paralogues in epigenetic silencing of P. falciparum virulence genes and the control of pathogenicity of malaria infection. PMID:19402747

  10. Obituary: Michael James Ledlow, 1964-2004

    NASA Astrophysics Data System (ADS)

    Puxley, Philip John; Grashuis, Randon M.

    2004-12-01

    Michael James Ledlow died on 5 June 2004 from a large, unsuspected brain tumor. Since 2000 he had been on the scientific staff of the Gemini Observatory in La Serena, Chile, initially as a Science Fellow and then as a tenure-track astronomer. Michael was born in Bartlesville, Oklahoma on 1 October 1964 to Jerry and Sharon Ledlow. He obtained his Bachelor Degree in astrophysics at the University of Oklahoma in 1987 and attended the University of New Mexico for his graduate work, obtaining his PhD while studying Galaxy Clusters under Frazer Owen in 1994. From 1995-1997 Michael held a postdoctoral position with Jack Burns at New Mexico State University where he used various astronomical facilities including the VLA and Apache Point Observatory to study distant galaxies. From 1998-2000 Michael rejoined the Physics and Astronomy Department at the University of New Mexico where he was a visiting professor until he moved on to Gemini. At the Gemini Observatory, Mike shared in the excitement, hard work and many long days and nights associated with bringing on-line a major new astronomical facility and its instrumentation. Following its commissioning he assisted visiting observers, supported and took data for many more remote users via the queue system, and for each he showed the same care and attention to detail evident in his own research to ensure that all got the best possible data. His research concentrated on the radio and optical properties of galaxy clusters, especially rich Abell clusters such as A2125, on luminous radio galaxies, including the detection of a powerful double radio source in the "wrong sort of galaxy," the spiral system 0313-192, and on EROs (extremely red objects), dusty galaxies barely detectable at optical wavelengths. Michael thoroughly enjoyed living in Chile and enthusiastically immersed himself in the culture of his surroundings. He and his family were actively involved with the International English Spanish Association in La Serena. He had a

  11. External calibration of SIR-B imagery with area-extended and point targets

    NASA Technical Reports Server (NTRS)

    Dobson, M. C.; Ulaby, Fawwaz T.; Brunfeldt, D. R.; Held, D. N.

    1985-01-01

    Data-takes on two ascending orbits of the Shuttle Imaging Radar-B (SIR-B) over an agricultural test site in west-central Illinois were used to establish end-to-end transfer functions for conversion of the digital numbers on the 8-bit image to values of the radar backscattering coefficient sigma sup 0 (sq m/sq. m) in dB. The transfer function for each data-take was defined by the SIR-B response to an array of six calibrated point targets of known radar cross-section (transponders) and to a large number of area-extended targets also with known radar cross-section as measured by externally calibrated, truck-mounted scatterometers. The radar cross-section of each transponder at the SIR-B center frequency was measured on an antenna range as a function of local angle of incidence. Two truck-mounted scatterometers observed 20 to 80 agricultural fields daily at 1.6 GHz with HH polarization and at azimuth viewing angles and incidence angles equivalent to those of the SIR-B. The form of the transfer function is completely defined by the SIR-B receiver and the incoherent averaging procedure incorporated into production of the standard SIR-B image product.

  12. Revisiting node-based SIR models in complex networks with degree correlations

    NASA Astrophysics Data System (ADS)

    Wang, Yi; Cao, Jinde; Alofi, Abdulaziz; AL-Mazrooei, Abdullah; Elaiw, Ahmed

    2015-11-01

    In this paper, we consider two growing networks which will lead to the degree-degree correlations between two nearest neighbors in the network. When the network grows to some certain size, we introduce an SIR-like disease such as pandemic influenza H1N1/09 to the population. Due to its rapid spread, the population size changes slowly, and thus the disease spreads on correlated networks with approximately fixed size. To predict the disease evolution on correlated networks, we first review two node-based SIR models incorporating degree correlations and an edge-based SIR model without considering degree correlation, and then compare the predictions of these models with stochastic SIR simulations, respectively. We find that the edge-based model, even without considering degree correlations, agrees much better than the node-based models incorporating degree correlations with stochastic SIR simulations in many respects. Moreover, simulation results show that for networks with positive correlation, the edge-based model provides a better upper bound of the cumulative incidence than the node-based SIR models, whereas for networks with negative correlation, it provides a lower bound of the cumulative incidence.

  13. An ARS element inhibits DNA replication through a SIR2-dependent mechanism.

    PubMed

    Crampton, Amber; Chang, FuJung; Pappas, Donald L; Frisch, Ryan L; Weinreich, Michael

    2008-04-25

    During G1 phase, a prereplicative complex (pre-RC) that determines where DNA synthesis initiates forms at origins. The Sir2p histone deacetylase inhibits pre-RC assembly at a subset of origins, suggesting that Sir2p inhibits DNA replication through a unique aspect of origin structure. Here, we identified five SIR2-sensitive origins on chromosomes III and VI. Linker scan analysis of two origins indicated that they share a common organization, including an inhibitory sequence positioned 3' to the sites of origin recognition complex (ORC) binding and pre-RC assembly. This inhibitory sequence (I(S)) required SIR2 for its activity, suggesting that SIR2 inhibits origins through this sequence. Furthermore, I(S) elements occurred within positioned nucleosomes, and Abf1p-mediated exclusion of nucleosomes from the origin abrogated the inhibition. These data suggest that Sir2p and I(S) elements inhibit origin activity by promoting an unfavorable chromatin structure for pre-RC assembly. PMID:18439895

  14. SIRS NEESPI megaproject on land - atmosphere processes in Siberia: results and perspectives

    NASA Astrophysics Data System (ADS)

    Gordov, E. P.; Kabanov, M. V.; Lykosov, V. N.; Vaganov, E. A.

    2009-04-01

    The Siberia Integrated Regional Study (SIRS, http://sirs.scert.ru/en/) is the Siberia-focused NEESPI Mega-Project. SIRS is developed in line with Earth System Science Program (ESSP) approach in cooperation of Russian Academy of Science (Siberian Branch) specialists with their European, American and Asian partners/counterparts and is aimed at coordination of multidisciplinary and "distributed" teams of specialists carrying out different scale projects on Siberia environment dynamics. Currently SIRS is supervised by the Russian National Committee for IGBP and managed by its Siberian Branch. Reported are recent results of investigations of the two major Siberian ecosystems dynamics, which are boreal forests and wetlands, with special emphasis on their role in the carbon cycle as well as results of climatic modeling for the region under study and first elements of the SIRS information-computational infrastructure forming glue for relevant multidisciplinary research. Among those are: recent results obtained at the Zotino Tall Tower Observation Facility; analysis of carbon balance between СО2 emission and accumulation based on ground observations performed at the Great Vasyugan Bog, recent development in high resolution regional climate modeling and new elements of the SIRS information-computational infrastructure. New SB RAS initiatives aimed at organization across Siberia a set of environmental observatories to monitor regional ecosystems and climate dynamics with special emphasis upon desertification and permafrost thawing processes and synchronized development of distributed facilities supporting obtained data storage and delivery are described in details. Scientific plans relying upon these developments are discussed as well.

  15. Scientific objectives and selection of targets for the SMART-1 Infrared Spectrometer (SIR)

    USGS Publications Warehouse

    Basilevsky, A.T.; Keller, H.U.; Nathues, A.; Mall, U.; Hiesinger, H.; Rosiek, M.

    2004-01-01

    The European SMART-1 mission to the Moon, primarily a testbed for innovative technologies, was launched in September 2003 and will reach the Moon in 2005. On board are several scientific instruments, including the point-spectrometer SMART-1 Infrared Spectrometer (SIR). Taking into account the capabilities of the SMART-1 mission and the SIR instrument in particular, as well as the open questions in lunar science, a selection of targets for SIR observations has been compiled. SIR can address at least five topics: (1) Surface/regolith processes; (2) Lunar volcanism; (3) Lunar crust structure; (4) Search for spectral signatures of ices at the lunar poles; and (5) Ground truth and study of geometric effects on the spectral shape. For each topic we will discuss specific observation modes, necessary to achieve our scientific goals. The majority of SIR targets will be observed in the nadir-tracking mode. More than 100 targets, which require off-nadir pointing and off-nadir tracking, are planned. It is expected that results of SIR observations will significantly increase our understanding of the Moon. Since the exact arrival date and the orbital parameters of the SMART-1 spacecraft are not known yet, a more detailed planning of the scientific observations will follow in the near future. ?? 2004 Elsevier Ltd. All rights reserved.

  16. Obituary: James Adolph Westphal, 1930-2004

    NASA Astrophysics Data System (ADS)

    Danielson, G. Edward

    2004-12-01

    James A. Westphal died September 8, 2004. He had battled a neurological disease related to Alzheimer's for the past year. He was 74. James A. Westphal was born in Dubuque, Iowa, on June 13, 1930. He was raised in Tulsa, Oklahoma, and in Little Rock, Arkansas. Westphal earned his bachelor's degree in physics from the University of Tulsa in 1954, a year after he went to work as geophysical research group leader at Sinclair Research Lab in Tulsa. Westphal first got into the business of scientific instrumentation right after high school, when he did well-logging in Texas and Gulf Coast oil fields. In fact, his work at Sinclair Research Labs involved devising unorthodox methods for oil discovery; one of his discoveries of a new way of processing seismic data first brought him to the attention of Caltech professor Hewitt Dix, who is often considered the father of exploration geophysics. Westphal arrived at Caltech initially on a four-month leave of absence to devise a data processor for Dix, but never left. He discovered that the academic freedom individual professors enjoy was amenable to his own predilections, so he soon began branching out to other areas of scientific investigation at Caltech. Before long, he had teamed up with Bruce Murray to do thermal infrared scans of the moon in order to see if humans could even walk on the lunar surface without sinking into the dusty soil. Westphal and Murray's work showed that rocky areas could be identified with the thermal imaging, which in turn led to the inference that the Apollo astronauts could safely walk on the soil without sinking. Westphal and Murray also teamed up to do the first infrared imaging of Venus and Jupiter. Other projects at Caltech led to Westphal's being hired on permanently by Bob Sharp, who at the time was the geology division chairman. In the following years, Westphal involved himself in novel ways of studying volcanism in Hawaii and Mount St. Helens. He invented a simple and very sensitive tilt meter

  17. Obituary: James C. Kemp, 1927-1988

    NASA Astrophysics Data System (ADS)

    Milone, E. F.

    2009-01-01

    James C. Kemp was born in Detroit, Michigan on 9 February 1927, and died in Eugene, Oregon, on 29 March 1988. He went to high school in Mexico City and did undergraduate studies at the University of Michigan and University of California at Berkeley. Kemp was an active observational astronomer, having migrated from earlier interests in Slavic languages, in which he majored, electrical engineering, and physics. He obtained a PhD in electrical engineering at Berkeley in 1960 and did post-doctoral work there with Erwin Hahn on spin resonance. He went to the University of Oregon in 1961 and conducted research in magneto-optics, developing, in the process, a piezo-optical birefringence modulator to measure circular polarization. The modulator is described by Tinbergen (1996). Kemp explored new areas as he measured magnetic fields in the sunspots with polarized infrared light, and developed polarimeters and photometers to study the behavior of such astronomical sources as white dwarfs, the relativistic jets of binary SS 433, the x-ray binary Cyg X-1, and the bright eclipsing binaries Algol and e Aurigae on the 61- and, later, 81-cm telescope at the Pine Mountain Observatory, of which Kemp was director until his death from cancer. His measurement of circularly polarization in the continuum light of the white dwarf GJ 742 (Grw +70∘ 8247, Kemp et al. 1970b) was an important discovery, and through his study of Algol (Kemp et al. 1983; Wilson & Liou 1993), he appears to have been the first to discover the limb polarization in eclipsing binaries predicted by Chandrasekhar (1946ab). Although it has taken twenty years for the BAAS to publish his obituary notice, it is somewhat appropriate that his former student, Gary Henson, who provided much of the background for this article, is involved with a polarimetry team to observe and analyze data from e Aurigae, as it approaches ingress of the next primary minimum beginning summer, 2009. The author acknowledges with gratitude the

  18. The Permanent Secretary as Policy-Maker, Shaper, Taker, Sharer, and Resister in Education--Reflections on Sir James Hamilton as a Centralising Outsider

    ERIC Educational Resources Information Center

    Ribbins, Peter; Sherratt, Brian

    2013-01-01

    Given that elevation to permanent secretary is widely recognised as the apotheosis of a career in the Whitehall bureaucracy, it is remarkable that so few have been the subject of sustained biographical research and that this key role remains largely un-theorised. As such, this paper reports on aspects of a longitudinal study which set out to…

  19. Ectogenesis, justice and utility: a reply to James.

    PubMed

    Wells, Deane

    1987-10-01

    In one chapter of their 1984 book The Reproductive Revolution (published in North America as Making Babies), Wells and Peter Singer make a case for the development of ectogenesis, the complete gestation of a human fetus outside the womb. David N. James responded with "Ectogenesis: a reply to Singer and Wells" (Bioethics, 1987 Jan; 1(1): 80-99), in which he refuted one of their arguments at length, opposed two briefly, and set two aside. Here Wells answers James, devoting most of his essay to reiterating an argument for ectogenesis based on the justice of remedying a correctable disability (infertility) by allocating resources to develop a biotechnology (ectogenesis). Wells then touches upon James's response to the Wells/Singer argument for ectogenesis as a possible solution to the abortion dilemma. He concludes by commenting briefly on the arguments about ectogenesis and parenting, and on ectogenesis as a source of transplantable tissue and organs. PMID:11651909

  20. Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS)

    PubMed Central

    Caserta, Stefano; Kern, Florian; Cohen, Jonathan; Drage, Stephen; Newbury, Sarah F.; Llewelyn, Martin J.

    2016-01-01

    Systemic inflammation in humans may be triggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic inflammatory response syndrome (SIRS). MicroRNAs regulate cellular processes including inflammation and may be detected in blood. We aimed to establish definitive proof-of-principle that circulating microRNAs are differentially affected during sepsis and non-infective SIRS. Critically ill patients with severe (n = 21) or non-severe (n = 8) intra-abdominal sepsis; severe (n = 23) or non-severe (n = 21) non-infective SIRS; or no SIRS (n = 16) were studied. Next-generation sequencing and qRT-PCR were used to measure plasma microRNAs. Detectable blood miRNAs (n = 116) were generally up-regulated in SIRS compared to no-SIRS patients. Levels of these ‘circulating inflammation-related microRNAs’ (CIR-miRNAs) were 2.64 (IQR: 2.10–3.29) and 1.52 (IQR: 1.15–1.92) fold higher for non-infective SIRS and sepsis respectively (p < 0.0001), hence CIR-miRNAs appeared less abundant in sepsis than in SIRS. Six CIR-miRNAs (miR-30d-5p, miR-30a-5p, miR-192-5p, miR-26a-5p, miR-23a-5p, miR-191-5p) provided good-to-excellent discrimination of severe sepsis from severe SIRS (0.742–0.917 AUC of ROC curves). CIR-miRNA levels inversely correlated with pro-inflammatory cytokines (IL-1, IL-6 and others). Thus, among critically ill patients, sepsis and non-infective SIRS are associated with substantial, differential changes in CIR-miRNAs. CIR-miRNAs may be regulators of inflammation and warrant thorough evaluation as diagnostic and therapeutic targets. PMID:27320175

  1. Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS).

    PubMed

    Caserta, Stefano; Kern, Florian; Cohen, Jonathan; Drage, Stephen; Newbury, Sarah F; Llewelyn, Martin J

    2016-01-01

    Systemic inflammation in humans may be triggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic inflammatory response syndrome (SIRS). MicroRNAs regulate cellular processes including inflammation and may be detected in blood. We aimed to establish definitive proof-of-principle that circulating microRNAs are differentially affected during sepsis and non-infective SIRS. Critically ill patients with severe (n = 21) or non-severe (n = 8) intra-abdominal sepsis; severe (n = 23) or non-severe (n = 21) non-infective SIRS; or no SIRS (n = 16) were studied. Next-generation sequencing and qRT-PCR were used to measure plasma microRNAs. Detectable blood miRNAs (n = 116) were generally up-regulated in SIRS compared to no-SIRS patients. Levels of these 'circulating inflammation-related microRNAs' (CIR-miRNAs) were 2.64 (IQR: 2.10-3.29) and 1.52 (IQR: 1.15-1.92) fold higher for non-infective SIRS and sepsis respectively (p < 0.0001), hence CIR-miRNAs appeared less abundant in sepsis than in SIRS. Six CIR-miRNAs (miR-30d-5p, miR-30a-5p, miR-192-5p, miR-26a-5p, miR-23a-5p, miR-191-5p) provided good-to-excellent discrimination of severe sepsis from severe SIRS (0.742-0.917 AUC of ROC curves). CIR-miRNA levels inversely correlated with pro-inflammatory cytokines (IL-1, IL-6 and others). Thus, among critically ill patients, sepsis and non-infective SIRS are associated with substantial, differential changes in CIR-miRNAs. CIR-miRNAs may be regulators of inflammation and warrant thorough evaluation as diagnostic and therapeutic targets. PMID:27320175

  2. Obituary: James Gilbert Baker, 1914-2005

    NASA Astrophysics Data System (ADS)

    Baker, Neal Kenton

    2005-12-01

    Dr. James Gilbert Baker, renowned astronomer and optical physicist, died 29 June 2005 at his home in Bedford, New Hampshire at the age of 90. Although his scientific interest was astronomy, his extraordinary ability in optical design led to the creation of hundreds of optical systems that supported astronomy, aerial reconnaissance, instant photography (Polaroid SX70 camera), and the US space programs. He was the recipient of numerous awards for his creative work. He was born in Louisville, Kentucky, on 11 November 1914, the fourth child of Jesse B. Baker and Hattie M. Stallard. After graduating from Louisville DuPont Manual High, he went on to attend the University of Louisville majoring in Mathematics. He became very close to an Astronomy Professor, Dr. Moore, and many times used his telescopes to do nightly observations. While at the university, he built mirrors for his own telescopes and helped form the Louisville Astronomical Society in 1933. At the University of Louisville, he also met his future wife, Elizabeth Katherine Breitenstein of Jefferson County, Kentucky. He received his BA in 1935 at the height of the Depression. He began his graduate work in astronomy at the Harvard College Observatory. After his MA (1936), he was appointed a Junior Fellow (1937-1943) in the Prestigious Harvard Society of Fellows. He received his PhD in 1942 from Harvard in rather an unusual fashion, which is worth retelling. During an Astronomy Department dinner, Dr. Harlow Shapley (the director) asked him to give a talk. According to the "Courier-Journal Magazine", "Dr. Shapley stood up and proclaimed an on-the-spot departmental meeting and asked for a vote on recommending Baker for a Ph.D. on the basis of the 'oral exam' he had just finished. The vote was unanimous." It was at Harvard College Observatory during this first stage of his career that he collaborated with Donald H. Menzel, Lawrence H. Aller, and George H. Shortley on a landmark set of papers on the physical processes

  3. Secondary ("Plain Mirror") Testing Methods of Sir William Herschel

    NASA Astrophysics Data System (ADS)

    Albin, E. F. M.

    2004-12-01

    Although many of Sir William Herschel's telescope designs did not require a secondary mirror, he did construct Newtonian style optical systems that used "plain mirrors." A look at Herschel's own writings on the matter gives some interesting insights into the techniques of this skilled 18th - 19th century telescope maker. The author provides glimpses acquired from unpublished Herschel documents that are now in the possession of the British RAS -- these include a four volume series entitled "Experiments on the Construction of Specula," a 129 page treaty called "On the Construction of Specula," and a 179 page manuscript entitled "Results of Experiments on the Construction of Mirrors." Herschel constructed secondary mirrors for his instruments by grinding and polishing his small mirrors in a sequence that involved two tools. He tested the optical quality of a small plain mirror by utilizing two slips of white card or pasteboard. One slip was made exactly twice the length of the second. The shorter card was placed against the mirror while the longer placed at some distance away so that its reflected image exactly matched the other. The larger card was carefully placed near the eye and oriented so that it was parallel to the shorter card strip. In order to test various sections of the secondary mirror, cards of different length were used. The mirror was judged flat if the reflected image was exactly identical to the card resting on the mirror. If the mirror were concave, the reflected image would be larger (i.e., magnified) than that of the smaller slip. However, should the reflected image be lesser in size, then the mirror was convex. Figuring was done with the mirror resting above the polishing tool. A convex mirror could be made plain by lengthening the stroke while a concave mirror could be made plain by shortening the stroke.

  4. Obituary: James N. Kile, 1958-2007

    NASA Astrophysics Data System (ADS)

    Cliver, Edward W.; Lang, Kenneth R.; Willson, Robert F.

    2009-01-01

    James N. Kile, of Needham Heights, Massachusetts, died on 17 August 2007, following a brave two-year battle with cancer. One of three children of David R. Kile and Betty Jane Kile, Jim was born in Niagara Falls, New York, on 20 April 1958 and lived in the nearby village of Lewiston before his family settled in Alden, an hour east of Niagara Falls, when Jim was nine. Jim's father worked for American Telephone and Telegraph for 37 years, and his mother was a homemaker. Jim earned his Bachelor's degree in Physics from Rensselaer Polytechnic Institute in 1980, a Master's degree from Northwestern University in 1982, and a Doctorate from Tufts University in 1996 under the direction of Robert Willson. His thesis involved comparison of radio data from the Very Large Array and the Russian RATAN 600 telescope with Yohkoh soft X-ray data, with an emphasis on understanding the relationship between solar noise storms and coronal magnetic fields. While working on his thesis, Jim collaborated with one of us (EWC) at the Air Force Research Laboratory on an investigation of the 154-day periodicity in solar flares. The resulting publication (ApJ 370, 442, 1991) is his most cited work. Jim co-authored four other papers in refereed journals. Jim's professional affiliations included the American Astronomical Society, the American Institute of Aeronautics and Astronautics, the American Geophysical Union, and the Astronomical Society of the Pacific. Jim worked as a contractor in the defense industry from 1982 until the time of his death, settling in the Boston area in the early 1980s. He worked for Calspan Corporation from 1982-1989, the Ultra Corporation from 1989-1994, and the Riverside Research Institute from 1994-2007. He was a highly-respected expert in radar systems, including radar data and systems analysis, systems engineering, and planning support for radar acquisition programs and technology development. The work entailed frequent extended travel to Norway for system testing

  5. Obscurity and Gender Resistance in Patricia Duncker's James Miranda Barry

    PubMed Central

    Funke, Jana

    2012-01-01

    Since his death in 1865, military surgeon James Barry has alternately been classified as a cross-dressing woman or as an intersexed individual. Patricia Duncker's novel James Miranda Barry (1999) poses an important challenge to such readings, as it does not reveal any foundational truth about Barry's sex. Resting on obscurity rather than revelation, the text frustrates the desire to know the past in terms of gender binaries and stable sexual identity categories. Drawing on feminist and queer theorisations of the relation between gender and time, this essay demonstrates that Duncker's use of obscurity opens up alternative strategies of gender resistance. PMID:25400502

  6. Obituary: James Adolph Westphal, 1930-2004

    NASA Astrophysics Data System (ADS)

    Danielson, G. Edward

    2004-12-01

    James A. Westphal died September 8, 2004. He had battled a neurological disease related to Alzheimer's for the past year. He was 74. James A. Westphal was born in Dubuque, Iowa, on June 13, 1930. He was raised in Tulsa, Oklahoma, and in Little Rock, Arkansas. Westphal earned his bachelor's degree in physics from the University of Tulsa in 1954, a year after he went to work as geophysical research group leader at Sinclair Research Lab in Tulsa. Westphal first got into the business of scientific instrumentation right after high school, when he did well-logging in Texas and Gulf Coast oil fields. In fact, his work at Sinclair Research Labs involved devising unorthodox methods for oil discovery; one of his discoveries of a new way of processing seismic data first brought him to the attention of Caltech professor Hewitt Dix, who is often considered the father of exploration geophysics. Westphal arrived at Caltech initially on a four-month leave of absence to devise a data processor for Dix, but never left. He discovered that the academic freedom individual professors enjoy was amenable to his own predilections, so he soon began branching out to other areas of scientific investigation at Caltech. Before long, he had teamed up with Bruce Murray to do thermal infrared scans of the moon in order to see if humans could even walk on the lunar surface without sinking into the dusty soil. Westphal and Murray's work showed that rocky areas could be identified with the thermal imaging, which in turn led to the inference that the Apollo astronauts could safely walk on the soil without sinking. Westphal and Murray also teamed up to do the first infrared imaging of Venus and Jupiter. Other projects at Caltech led to Westphal's being hired on permanently by Bob Sharp, who at the time was the geology division chairman. In the following years, Westphal involved himself in novel ways of studying volcanism in Hawaii and Mount St. Helens. He invented a simple and very sensitive tilt meter

  7. Shuttle Imaging Radar-A (SIR-A) data as a complement to Landsat Multispectral Scanner (MSS) data

    NASA Technical Reports Server (NTRS)

    Henninger, D. L.; Carney, J. H.

    1983-01-01

    Principal components analysis and supervised classifications were performed on two dates of Landsat multispectral scanner (MSS) data registered to one date of Shuttle Imaging Radar-A (SIR-A) data in a wheat-growing area of New South Wales, Australia. The purpose was to evaluate SIR-A data as a complement to Landsat MSS data in an agricultural environment. The SIR-A data was filtered using a 7 x 7 pixel moving window median filter. Principal components analysis indicated the SIR-A data were discriminating between trees and agricultural fields. Supervised classifications using wheat, pasture, trees, and idle classes resulted in increased accuracies for wheat and pasture and slightly decreased accuracies for trees and idle for the Landsat MSS/SIR-A registered data sets over the Landsat MSS alone. Overall classification accuracies were unchanged for one date and substantially increased for the other when the SIR-A data were added to the Landsat MSS data.

  8. Supporting Progressive Change: The James R. Squire Office of Policy Research

    ERIC Educational Resources Information Center

    Farrell, Edmund J.

    2004-01-01

    The NCTE has established a center of policy research to honor the legacy of James R. Squire in order to support progressive reform in English language arts education. James R. Squire's life and work are discussed in detail.

  9. 2. Historic American Buildings Survey James F. O'Gorman, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey James F. O'Gorman, Photographer April 1958 INTERIOR, DETAIL OF HOWE TRUSS, Gift of James F. O'Gorman 1959, HABS - Sandy Creek Bridge, Goldman, Jefferson County, MO

  10. Slx5 Promotes Transcriptional Silencing and Is Required for Robust Growth in the Absence of Sir2▿ †

    PubMed Central

    Darst, Russell P.; Garcia, Sandra N.; Koch, Melissa R.; Pillus, Lorraine

    2008-01-01

    The broadly conserved Sir2 NAD+-dependent deacetylase is required for chromatin silencing. Here we report the discovery of physical and functional links between Sir2 and Slx5 (Hex3), a RING domain protein and subunit of the Slx5/8 complex column, which is a ubiquitin E3 ligase that targets sumoylated proteins. Slx5 interacted with Sir2 by two-hybrid and glutathione S-transferase-binding assays and was found to promote silencing of genes at telomeric or ribosomal DNA (rDNA) loci. However, deletion of SLX5 had no detectable effect on the distribution of silent chromatin components and only slightly altered the deacetylation of histone H4 lysine 16 at the telomere. In vivo assays indicated that Sir2-dependent silencing was functionally intact in the absence of Slx5. Although no previous reports suggest that Sir2 contributes to the fitness of yeast populations, we found that Sir2 was required for maximal growth in slx5Δ mutant cells. A similar requirement was observed for mutants of the SUMO isopeptidase Ulp2/Smt4. The contribution of Sir2 to optimal growth was not due to known Sir2 roles in mating-type determination or rDNA maintenance but was connected to a role of sumoylation in transcriptional silencing. These results indicate that Sir2 and Slx5 jointly contribute to transcriptional silencing and robust cellular growth. PMID:18086879

  11. SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

    PubMed Central

    Peng, Chi-Hsien; Chang, Yuh-Lih; Kao, Chung-Lan; Tseng, Ling-Ming; Wu, Chih-Chia; Chen, Yu-Chih; Tsai, Ching-Yao; Woung, Lin-Chung; Liu, Jorn-Hon; Chiou, Shih-Hwa; Chen, Shih-Jen

    2010-01-01

    Retinal stem cells bear potency of proliferation, self-renewal, and differentiation into many retinal cells. Utilizing appropriate sensors one can effectively detect the self-renewal and aging process abilities. Silencing information regulator (SirT1), a member of the sirtuin family, is a NAD-dependent histone deacetylase and an essential mediator for longevity in normal cells by calorie restriction. We firstly investigate the SirT1 mRNA expression in retinal stem cells from rats and 19 human eyes of different ages. Results revealed that SirT1 expression was significantly decreased in in vivo aged eyes, associated with poor self-renewal abilities. Additionally, SirT1 mRNA levels were dose-dependently increased in resveratrol- treated retinal stem cells. The expression of SirT1 on oxidative stress-induced damage was significantly decreased, negatively correlated with the level of intracellular reactive oxygen species production. Treatment with resveratrol could effectively further reduce oxidative stress induced by H2O2 treatment in retinal stem cells. Importantly, the anti-oxidant effects of resveratrol in H2O2-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1). SirT1 expression provides a feasible sensor in assessing self-renewal and aging process in retinal stem cells. Resveratrol can prevent reactive oxygen species-induced damages via increased retinal SirT1 expression. PMID:22219708

  12. William James' legacy to Alcoholics Anonymous: an analysis and a critique.

    PubMed

    Walle, A H

    1992-01-01

    When evolving a philosophy and a "modus operandi" the pioneers of Alcoholics Anonymous made significant use of William James' Varieties of Religious Experience. Indeed, although AA carefully picked and chose various of James' ideas which seemed particularly relevant, James' imprint is clearly stamped upon AA philosophy and methodology. Here, I will review James' work and explore what specific ideas were particularly relevant to AA's evolution as a self-help movement. The implications of this heritage will be explored. PMID:1627669

  13. 10. Historic American Buildings Survey James Rainey, Photographer February 17, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey James Rainey, Photographer February 17, 1937 SOUTHWEST VIEW OF CARRIAGE SHED carriage made by George + David Cook + Co., New Haven- #104 'Hamilton Coach' - $1,200 on left - #60 'Boston Chaise' in Cook 1860 catalogue - John Morris House, Lighthouse Road & Morris Avenue, New Haven, New Haven County, CT

  14. Astronaut James Lovell checks body temperature with oral temperature probe

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Gemini 7 pilot Astronaut James A. Lovell Jr. has temperature check with oral temperature probe attached to his space suit during final preflight preparations for the Gemini 7 space mission. The temperature probe allows doctors to monitor astronauts body temperature at any time during the mission.

  15. Astronaut James van Hoften working with Syncom IV-3 satellite

    NASA Technical Reports Server (NTRS)

    1985-01-01

    A 16mm motion picture camera was used to show Astronaut James D. van Hoften as he gives a shove to the previously troubled Syncom IV-3 communications satellite. Dr. van Hoften stands on a foot restraint/extension to the remote manipulator system (RMS) arm.

  16. Shake, Rattle and Roll: James Webb Telescope Components Pass Tests

    NASA Technical Reports Server (NTRS)

    2008-01-01

    This image shows a model of one of three detectors for the Mid-Infrared Instrument on NASA's upcoming James Webb Space Telescope. The detector, which looks green in this picture, and is similar to the charge-coupled devices, or 'CCDs,' in digital cameras, is housed in the brick-like unit shown here, called a focal plane module.

  17. A Composition Curriculum Based on James Britton's Theories.

    ERIC Educational Resources Information Center

    Monahan, Brian D.; Zelner, Jane

    In 1979, the Yonkers Public School district (New York) launched a project to design and implement secondary school language arts curriculum guides with an emphasis on written composition. A theoretical framework was developed, based on the work of James Britton and the philosophy of the Bay Area Writing Project (BAWP). Britton's work provided the…

  18. Astronaut James Lovell hoisted from water by recovery helicopter

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Astronaut James A. Lovell Jr., pilot of the Gemini 7 space flight, is hoisted from the water by a recovery helicopter from the Aircraft Carrier U.S.S. Wasp. Astronaut Frank Borman, command pilot, waits in the raft to be hoisted aboard the helicopter.

  19. 35. James River Visitor Center. Opened as an open air ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. James River Visitor Center. Opened as an open air visitor center in 1962, it was enclosed and a heating system installed in 1984 to allow use through the cooler months and help reduce vandalism. Looking northeast. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  20. 11. INTERIOR VIEW WITH JAMES WILLIAMS INSIDE GREY IRON UNIT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. INTERIOR VIEW WITH JAMES WILLIAMS INSIDE GREY IRON UNIT NO. 1 MOLDING CONVEYOR, AIR CLEANING A PATTERN AS IT SITS WITHIN A FLASK ON A MOLDING MACHINE PRIOR TO BEING FILLED WITH SAND FROM THE OVERHEAD CONVEYOR. - Stockham Pipe & Fittings Company, Grey Iron Foundry, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  1. 12. INTERIOR VIEW WITH JAMES WILLIAMS REACHING FOR THE SAND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. INTERIOR VIEW WITH JAMES WILLIAMS REACHING FOR THE SAND RELEASE LEVER WHICH WILL OPEN THE OVERHEAD STORAGE BIN AND PERMIT A SET AMOUNT OF SAND TO BE DEPOSITED INTO THE FLASK PRIOR TO COMPRESSION BY THE MOLDING MACHINE INSIDE GREY IRON UNIT NO. 1. - Stockham Pipe & Fittings Company, Grey Iron Foundry, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  2. Pestalozzi and James Pierrepont Greaves: A Shared Educational Philosophy.

    ERIC Educational Resources Information Center

    Latham, Jackie E. M.

    2002-01-01

    Focuses on Johann H. Pestalozzi, James Pierrepont Greaves, and Reverend Charles Mayo. States that Greaves and Mayo disseminated Pestalozzi's ideas and techniques in England. Explains that Pestalozzi and Greaves trained elementary teachers to view students' talents and personal growth as a whole person concept. Argues less effort would limit…

  3. INTERIOR VIEW OF JAMES HARRIS CUTTING SCREW THREADS INTO THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR VIEW OF JAMES HARRIS CUTTING SCREW THREADS INTO THE INTERIOR OF FITTINGS ON ONE IN A BANK OF TAPPING MACHINES, EACH OPERATED BY THE SAME WORKER SIMULTANEOUSLY BUT TIMED TO REQUIRE WORKER ACTION AT INTERVALS THAT DO NOT INTERFERE WITH THE OTHER MACHINES. - Stockham Pipe & Fittings Company, Tapping Room, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  4. Beyond Walls: A Strategic Plan for James White Library.

    ERIC Educational Resources Information Center

    Andrews Univ., Berrien Springs, MI. James White Library.

    The strategic plan for the James White Library of Andrews University uses the phrase "beyond walls," rather than the catchphrase "library without walls," to acknowledge that printed matter is here to stay but that the paradigm in which it operates is open to innovation and exploration. The fundamental changes taking place in libraries will not…

  5. James Van Allen and His Namesake NASA Mission

    NASA Astrophysics Data System (ADS)

    Baker, D. N.; Hoxie, V. C.; Jaynes, A.; Kale, A.; Kanekal, S. G.; Li, X.; Reeves, G. D.; Spence, H. E.

    2013-12-01

    In many ways, James A. Van Allen defined and "invented" modern space research. His example showed the way for government-university partners to pursue basic research that also served important national and international goals. He was a tireless advocate for space exploration and for the role of space science in the spectrum of national priorities.

  6. Detector Arrays for the James Webb Near Infrared Spectrograph

    NASA Technical Reports Server (NTRS)

    Rauscher, Bernard J.

    2009-01-01

    NASA Goddard Space Flight Center is delivering the detector subsystem for the James Webb Space Telescope (JWST) Near Infrared Spectrograph (NIRSpec). Of all JWST instruments, NIRSpec has the most stringent detector requirements. In this poster, we describe recent performance testing results and relate them to NIRSpec's science requirements.

  7. Plan of the principal (second) floor of James H. Windrim ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Plan of the principal (second) floor of James H. Windrim and George Summers’s competition design for the New Masonic Temple, Philadelphia, 1867. The exterior wall outline of the architects’ Early Norman alternative design is shown overlaid across the left third of the drawing. - Masonic Temple, 1 North Broad Street, Philadelphia, Philadelphia County, PA

  8. James Webb Space Telescope (JWST) Primary Mirror Material Selection

    NASA Technical Reports Server (NTRS)

    Stahl, H. Philip; Feinberg, Lee D.; Russell, Kevin; Texter, Scott

    2004-01-01

    The James Webb Space Telescope (JWST) conducted a phase down select process via the Advanced Mirror System Demonstrator (AMSD) project to assess the Technology Readiness Level of various candidate mirror materials. This process culminated in the selection of Beryllium as the JWST primary mirror material. This paper outlines the mirror evaluation process, defines the selection criteria and summarizes the candidate mirror's performances.

  9. James Carter: Champion of the Normal School Movement.

    ERIC Educational Resources Information Center

    Flaherty, Thomas F.; Flaherty, John J.

    This paper presents a historical review of the gradual growth of interest in an establishment of legislation in Massachusetts for institutions concerned exclusively with the training of teachers. Highlighted is the activity of James G. Carter in this endeavor. The state of education at the beginning of the nineteenth century is described: private…

  10. Perspective rendering of the Masonic Temple by James H. Windrim ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Perspective rendering of the Masonic Temple by James H. Windrim showing the abandoned intermediate design of the Broad Street facade with architectural details and allegorical figures selected to represent symbolic Masonry, 1868 - Masonic Temple, 1 North Broad Street, Philadelphia, Philadelphia County, PA

  11. Governor James Wright in Georgia, 1760-1782.

    ERIC Educational Resources Information Center

    Coleman, Kenneth

    One of a series of pamphlets about the American Revolution in Georgia, this document examines the role of James Wright as British governor in the colony, and his viewpoints about revolution from 1765-1775. The pamphlet can be used as supplementary reading or as a one-week unit for junior or senior high school students. A brief teacher's guide is…

  12. James Madison High: A School at the Crossroads

    ERIC Educational Resources Information Center

    Stroup, John T.; Salmonowicz, Michael J.; Broom, Christopher C.

    2007-01-01

    This case tells the story of James Madison High School, which became the epicenter of a debate over the future reorganization and control of large secondary schools in the Los Angeles Unified School District (LAUSD). The LAUSD, recently taken over by the newly elected mayor, was fighting for control of this 3,000-student high school with a charter…

  13. Picking up Galen: James Joyce in Cecilia Street.

    PubMed

    Lyons, J B

    1997-07-01

    James Joyce (1882-1941) registered as a student of the Catholic University Medical School, Cecilia Street, in 1902. His attendance in November was brief; by early December, Joyce was in Paris. A recently-acquired Guide for Medical Students, a booklet compiled by Ambrose Birmingham, dean of the Cecilia Street school, sheds light on this hitherto obscure episode. PMID:11619448

  14. 7. VARIABLEANGLE LAUNCHER DEDICATION PLAQUE SHOWING JAMES H. JENNISON (LEFT), ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. VARIABLE-ANGLE LAUNCHER DEDICATION PLAQUE SHOWING JAMES H. JENNISON (LEFT), AND W.H. SAYLOR (RIGHT), AT THE DEDICATION CEREMONY, May 7, 1948. (Original photograph in possession of Dave Willis, San Diego, California.) - Variable Angle Launcher Complex, CA State Highway 39 at Morris Reservior, Azusa, Los Angeles County, CA

  15. NCATE, PC, and the LCME: A Response to James Sutton.

    ERIC Educational Resources Information Center

    Parker, Jonathan K.

    1994-01-01

    Sympathizes with Iowa universities' decision to withdraw from National Council for Accreditation of Teacher Education (NCATE), despite James Sutton's objections in October 1993 issue of "Kappan." Preparation for NCATE accreditation costs too much; the language of the standards is too political. The Iowa presidents were frustrated by NCATE's…

  16. Astronaut James Newman evaluates tether devices in Discovery's payload bay

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Astronaut James H. Newman, mission specialist, evaluates various tether devices to be used during the Hubble Space Telescope (HST) servicing mission scheduled for later this year. Newman is tethered to the starboard side, with the orbital maneuvering system (OMS) pod just behind him.

  17. Astronaut James Newman evaluates tether devices in Discovery's payload bay

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Astronaut James H. Newman, mission specialist, uses a 35mm camera to take a picture of fellow astronaut Carl E. Walz (out of frame) in Discovery's cargo bay. The two were engaged in an extravehicular activity (EVA) to test equipment to be used on future EVA's. Newman is tethered to the starboard side, with the orbital maneuvering system (OMS) pod just behind him.

  18. Astronaut James Newman works with computers and GPS

    NASA Technical Reports Server (NTRS)

    1993-01-01

    On Discovery's middeck, Astronaut James H. Newman, mission specialist, works with an array of computers, including one devoted to Global Positioning System (GPS) operations, a general portable onboard computer displaying a tracking map, a portable audio data modem and another payload and general support computer.

  19. "To Mediate Relevantly": A Response to James Simpson

    ERIC Educational Resources Information Center

    Waters, Alan

    2009-01-01

    In Waters (2009), it was contended that, because of its ideological orientation, a good deal of applied linguistics for language teaching (ALLT) fails to "mediate relevantly" between academic and practitioner perspectives. James Simpson's rejoinder to my article (Simpson 2009) attempts to refute its claims. However, in my view, it fails to do so,…

  20. The James Webb Space Telescope Integrated Science Instrument Module

    NASA Technical Reports Server (NTRS)

    Greenhouse, Matthew A.; Sullivan, Pamela C.; Boyce, Leslye A.; Glazer, Stuart D.; Johnson, Eric L.; McCloskey, John C.; Voyton, Mark F.

    2004-01-01

    The Integrated Science Instrument Module of the James Webb Space Telescope is described from a systems perspective with emphasis on unique and advanced technology aspects. The major subsystems of this flight element are described including: structure, thermal, command and data handling, and software.

  1. Shake, Rattle and Roll: James Webb Telescope Components Pass Tests

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Mike Ressler (right) and Kalyani Sukhatme of JPL pose in the clean room with a model component, called a focal plane module, of the Mid-Infrared Instrument on NASA's James Webb Space Telescope. Ressler is the project scientist for the instrument, and Sukhatme is the project element manager for the instrument's focal plane module.

  2. Implementation of hazard analysis critical control point in jameed production.

    PubMed

    Al-Saed, A K; Al-Groum, R M; Al-Dabbas, M M

    2012-06-01

    The average of standard plate count and coliforms, Staphylococcus aureus and Salmonella counts for three home-made jameed samples, a traditional fermented dairy product, before applying hazard analysis critical control point system were 2.1 × 10(3), 8.9 × 10(1), 4 × 10(1) and less than 10 cfu/g, respectively. The developed hazard analysis critical control point plan resulted in identifying ten critical control points in the flow chart of jameed production. The critical control points included fresh milk receiving, pasteurization, addition of starter, water and salt, straining, personnel hygiene, drying and packaging. After applying hazard analysis critical control point system, there was significant improvement in the microbiological quality of the home-made jameed. The standard plate count was reduced to 3.1 × 10(2) cfu/g whereas coliform and Staphylococcus aureus counts were less than 10 cfu/g and Salmonella was not detected. Sensory evaluation results of color and flavor of sauce prepared from jameed showed a significant increase in the average scores given after hazard analysis critical control point application. PMID:22701056

  3. James Moffett's Mistake: Ignoring the Rational Capacities of the Other

    ERIC Educational Resources Information Center

    Donehower, Kim

    2013-01-01

    Using Alasdair MacIntyre's theory of tradition-bound rationalities, this essay analyses James Moffett's depiction of the censors who opposed his "Interactions" textbook series in the Kanawha County, West Virginia, schools. Many reviewers have found Moffett's analysis of the censors in "Storm in the Mountains" even-handed and…

  4. 75 FR 16520 - James A. Fitzpatrick Nuclear Power Plant; Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... have a significant effect on the quality of the human environment (75 FR 14637; dated March 26, 2010... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION James A. Fitzpatrick Nuclear Power Plant; Exemption 1.0 Background Entergy Nuclear Operations,...

  5. Lobell, Rickaby, and Vrugt Receive 2010 James B. Macelwane Medals

    NASA Astrophysics Data System (ADS)

    Gorelick, Steven M.; Lobell, David B.; Elderfield, Harry; Rickaby, Rosalind; Sorooshian, Soroosh; Vrugt, Jasper A.

    2011-03-01

    David B. Lobell, Rosalind E. Rickaby, and Jasper A. Vrugt were awarded the 2010 James B. Macelwane Medal at the AGU Fall Meeting Honors Ceremony, held on 15 December 2010 in San Francisco, Calif. The medal is for “significant contributions to the geophysical sciences by an outstanding young scientist.”

  6. James J. Gallagher: Man in the White Hat

    ERIC Educational Resources Information Center

    Jolly, Jennifer L.; Robinson, Ann

    2014-01-01

    In classic Western movies, the good guy could be frequently identified by his trademark white Stetson hat, whereas the bad guy always wore black. James J. Gallagher wore many hats during his career that spanned over six decades; he too would be known as the "man in the white hat,"--trusted to do the right thing. From 1967 to 1970,…

  7. The Adolescent Society: James Coleman's Still-Prescient Insights

    ERIC Educational Resources Information Center

    Coleman, James S.

    2006-01-01

    The high-school problem is nothing new. In one of his early writings, James S. Coleman, the brilliant sociologist who later wrote the famous report on the equality of opportunity for education (the "Coleman Report") and the first study of public and private schools, identified the essential high-school problem: "our adolescents today are cut off,…

  8. The Early Years of Watomika (James Bouchard): Delaware and Jesuit.

    ERIC Educational Resources Information Center

    Miller, Jay

    1989-01-01

    Publishes and critiques the 1855 autobiography of Jesuit Father James Bouchard, born and raised a Delaware named Watomika. Contains information about Watomika's family, genealogy, and early years; his conversion to Christianity; and Delaware religious beliefs and practices. Examines the literary and ethnographic merits of the autobiography. (SV)

  9. 37. Photographic copy of photograph, James K. Corrigan, Photographer, 1987, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. Photographic copy of photograph, James K. Corrigan, Photographer, 1987, (original print in Cooper-Howard Counties Job no. J5P0257 Project File, Cultural Resources Section, Design Division, Missouri Highway and Transportation Department, Jefferson City). Pennsylvania spans, aerial view to the southwest - Boonville Bridge, Spanning Missouri River at U.S. Route 40 & State Routes 5 & 87, Boonville, Cooper County, MO

  10. 34. Photographic copy of photograph, James K. Corrigan, Photographer, 1987, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. Photographic copy of photograph, James K. Corrigan, Photographer, 1987, (original print in Cooper-Howard Counties Job no. J5P0257 Project File, Cultural Resources Section, Design Division, Missouri Highway and Transportation Department, Jefferson City). Aerial view to the northeast - Boonville Bridge, Spanning Missouri River at U.S. Route 40 & State Routes 5 & 87, Boonville, Cooper County, MO

  11. 36. Photographic copy of photograph, James K. Corrigan, Photographer, 1987, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. Photographic copy of photograph, James K. Corrigan, Photographer, 1987, (original print in Cooper-Howard Counties Job no. J5P0257 Project File, Cultural Resources Section, Design Division, Missouri Highway and Transportation Department, Jefferson City). Aerial view to the southwest - Boonville Bridge, Spanning Missouri River at U.S. Route 40 & State Routes 5 & 87, Boonville, Cooper County, MO

  12. 35. Photographic copy of photograph, James K. Corrigan, Photographer, 1987, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. Photographic copy of photograph, James K. Corrigan, Photographer, 1987, (original print in Cooper-Howard Counties Job no. J5P0257 Project File, Cultural Resources Section, Design Division, Missouri Highway and Transportation Department, Jefferson City). Aerial view to the southeast - Boonville Bridge, Spanning Missouri River at U.S. Route 40 & State Routes 5 & 87, Boonville, Cooper County, MO

  13. 38. Photographic copy of photograph, James K. Corrigan, Photographer, 1987, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. Photographic copy of photograph, James K. Corrigan, Photographer, 1987, (original print in Cooper-Howard Counties Job no. J5P0257 Project File, Cultural Resources Section, Design Division, Missouri Highway and Transportation Department, Jefferson City). Parker spans, aerial view to the northwest - Boonville Bridge, Spanning Missouri River at U.S. Route 40 & State Routes 5 & 87, Boonville, Cooper County, MO

  14. 33. Photographic copy of photograph, James K. Corrigan, Photographer, 1987, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. Photographic copy of photograph, James K. Corrigan, Photographer, 1987, (original print in Cooper-Howard Counties Job no. J5P0257 Project File, Cultural Resources Section, Design Division, Missouri Highway and Transportation Department, Jefferson City). Aerial view to the northwest - Boonville Bridge, Spanning Missouri River at U.S. Route 40 & State Routes 5 & 87, Boonville, Cooper County, MO

  15. James Newton Howard: JAMs with TRI-M.

    ERIC Educational Resources Information Center

    Reninger, Rosemary D.

    2000-01-01

    Presents an interview with James Newton Howard, a film composer. Provides background information on Howard. Addresses topics such as his most challenging and rewarding scores, his musical background, and the benefits of being associated with the American Society of Composers, Authors, and Publishers (ASCAP). (CMK)

  16. Reflections on Policy in Gifted Education: James J. Gallagher

    ERIC Educational Resources Information Center

    Brown, Elissa F.; Garland, Rebecca B.

    2015-01-01

    In this article, Brown and Garland, reflect on issues raised by James J. Gallagher, such as educational policies helping to create and support an infrastructure within which the needs of students can be addressed. Gallagher felt that a strong federal policy, such as IDEA, was critical to building and maintaining a solid infrastructure. Gallagher…

  17. A Conversation with William Styron and James West.

    ERIC Educational Resources Information Center

    Hackney, Sheldon

    1997-01-01

    Presents two separate interviews on one topic. William Styron and James West discuss West's biography of Styron from the vantage points of subject and biographer. Styron reveals some of the painful incidents in his life and West delineates how these have influenced Styron's work. Includes several photographs. (MJP)

  18. Wise, Holistic Thinking: An Interview with James H. Borland

    ERIC Educational Resources Information Center

    Henshon, Suzanna E.

    2012-01-01

    This article presents an interview with James H. Borland, Professor of Education in the Department of Curriculum and Teaching at Teachers College, Columbia University, where he directs the graduate programs in the education of gifted students. Dr. Borland is the author of numerous books, book chapters, journal articles, and miscellanea. He has won…

  19. APOLLO 13 CREW JOHN SWIGERT, JAMES LOVELL, AND FRED HAISE

    NASA Technical Reports Server (NTRS)

    1970-01-01

    John L. Swigert, Jr., left, the Apollo 13 backup crewman being considered as command module pilot in place of Thomas K. Mattingly II because of the latter's exposure to measles, has been training with the prime crew -- James A. Lovell, Jr., center and Fred W. Haise, Jr.

  20. Astronaut James Wetherbee briefed on use of Sky Genie

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Astronaut James D. Wetherbee, STS-63 mission commander, is briefed on the use of Sky Genie device by Karin L. Porter. The device would aid in emergency egress operations aboard a troubled Space Shuttle. Porter, an employee of Rockwell International, helps train astronauts in egress procedures at JSC's Shuttle mockup and integration laboratory.

  1. The Word for Teaching Is Learning: Essays for James Britton.

    ERIC Educational Resources Information Center

    Lightfoot, Martin, Ed.; Martin, Nancy, Ed.

    Reflecting the influence of James Britton in the field of language and learning, this book--a collection of essays by researchers and practitioners in the area of language and learning--focuses on recent issues of language development in learning. The book contains the following 27 essays: (1) "Social Interaction as Scaffold: The Power and Limits…

  2. History through Red Eyes: A Conversation with James Loewen

    ERIC Educational Resources Information Center

    Jetty, Mike

    2006-01-01

    This article presents a conversation with James Loewen. Loewen is an author, historian, and professor. In a recent conversation with the author, he shared his views on how American Indian topics and events are traditionally taught and offered his insights into what teachers can do to accommodate multiple perspectives in their examination of…

  3. More than Mere Weather: James's Talks to Students about Life

    ERIC Educational Resources Information Center

    Wight, Randall D.

    2003-01-01

    William James addressed the last 3 lectures in "Talks to Teachers on Psychology and to Students on Some of Life's Ideals" (1899/1958) specifically to students. The first of these lectures, "The Gospel of Relaxation," encouraged students to be both relaxed and active. The second, "On a Certain Blindness in Human Beings," promoted awareness of and…

  4. William James: An Ethical Philosopher for Experiential Education.

    ERIC Educational Resources Information Center

    Page, Homer

    1987-01-01

    Discusses major thoughts of American philosopher William James and how they can serve as a guide to the actions of experiential educators. Considers propositions concerning freedom and responsibility; truth and reflection; happiness and joy; and sacrifice, protest, and inclusive caring. (NEC)

  5. The Genetic Psychologies of James Mark Baldwin and Jean Piaget.

    ERIC Educational Resources Information Center

    Cahan, Emily D.

    1984-01-01

    Describes the ideas proposed by James Mark Baldwin which anticipated much of Jean Piaget's work. The goals, genetic approach, and epistemological assumptions underlying Piaget's inquiry into cognitive development found explicit statement in Baldwin's work. Discusses Baldwin's current importance for psychology. (Author/CB)

  6. Williams and Doney receive 2000 James B. Macelwane medal

    NASA Astrophysics Data System (ADS)

    Lay, Thome; Williams, Quentin C.

    Quentin C. Williams and Scott C. Doney were awarded the James B. Macelwane Medal at the AGU Fall Meeting Honors Ceremony, which was held on December 17, 2000 in San Francisco, California. The medal recognizes significant contributions to the geophysical sciences by a young scientist of outstanding ability.

  7. View west of the James and Lucy Alexander gravestone and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View west of the James and Lucy Alexander gravestone and family plot among other demarcated family plots in the Female Union Band Cemetery. - Mount Zion Cemetery/ Female Union Band Cemetery, Bounded by 27th Street right-of-way N.W. (formerly Lyons Mill Road), Q Street N.W., & Mill Road N.W., Washington, District of Columbia, DC

  8. Science and James McKeen Cattell, 1894 to 1945.

    ERIC Educational Resources Information Center

    Sokal, Michael M.

    1980-01-01

    This article is a summary of James M. Cattell's editorship of the journal "Science" and role in establishing it as America's most important scientific journal. Included is the transfer of ownership to the American Association for the Advancement of Science (AAAS). (SA)

  9. Groundbreaking Investigator of Creativity: An Interview with James C. Kaufman

    ERIC Educational Resources Information Center

    Henshon, Suzanna E.

    2010-01-01

    This article presents an interview with James C. Kaufman, an associate professor of psychology at the California State University at San Bernardino, where he directs the Learning Research Institute. Kaufman received his PhD in cognitive psychology from Yale University in 2001. Dr. Kaufman's research broadly focuses on nurturing and encouraging…

  10. Clement, Hardebeck, and Nimmo Receive 2007 James B. Macelwane Medals

    NASA Astrophysics Data System (ADS)

    Cane, Mark A.; Clement, Amy C.; Michael, Andrew; Hardebeck, Jeanne L.; Stevenson, Dave; Nimmo, Francis

    2008-02-01

    Amy C. Clement, Jeanne L. Hardebeck, and Francis Nimmo were awarded the 2007 James B. Macelwane Medal at the AGU Fall Meeting Honors Ceremony, which was held on 12 December 2007 in San Francisco, Calif. The medal is ``for significant contributions to the geophysical sciences by a young scientist of outstanding ability.''

  11. Obituary: James Gilbert Baker, 1914-2005

    NASA Astrophysics Data System (ADS)

    Baker, Neal Kenton

    2005-12-01

    Dr. James Gilbert Baker, renowned astronomer and optical physicist, died 29 June 2005 at his home in Bedford, New Hampshire at the age of 90. Although his scientific interest was astronomy, his extraordinary ability in optical design led to the creation of hundreds of optical systems that supported astronomy, aerial reconnaissance, instant photography (Polaroid SX70 camera), and the US space programs. He was the recipient of numerous awards for his creative work. He was born in Louisville, Kentucky, on 11 November 1914, the fourth child of Jesse B. Baker and Hattie M. Stallard. After graduating from Louisville DuPont Manual High, he went on to attend the University of Louisville majoring in Mathematics. He became very close to an Astronomy Professor, Dr. Moore, and many times used his telescopes to do nightly observations. While at the university, he built mirrors for his own telescopes and helped form the Louisville Astronomical Society in 1933. At the University of Louisville, he also met his future wife, Elizabeth Katherine Breitenstein of Jefferson County, Kentucky. He received his BA in 1935 at the height of the Depression. He began his graduate work in astronomy at the Harvard College Observatory. After his MA (1936), he was appointed a Junior Fellow (1937-1943) in the Prestigious Harvard Society of Fellows. He received his PhD in 1942 from Harvard in rather an unusual fashion, which is worth retelling. During an Astronomy Department dinner, Dr. Harlow Shapley (the director) asked him to give a talk. According to the "Courier-Journal Magazine", "Dr. Shapley stood up and proclaimed an on-the-spot departmental meeting and asked for a vote on recommending Baker for a Ph.D. on the basis of the 'oral exam' he had just finished. The vote was unanimous." It was at Harvard College Observatory during this first stage of his career that he collaborated with Donald H. Menzel, Lawrence H. Aller, and George H. Shortley on a landmark set of papers on the physical processes

  12. "The Bravest of the Brave": A Conversation with Mary Bitterman and James Narduzzi

    ERIC Educational Resources Information Center

    Continuing Higher Education Review, 2008

    2008-01-01

    This article presents an interview with Mary Bitterman and James Narduzzi. Mary Bitterman, former President and CEO of The James Irvine Foundation, is President of The Bernard Osher Foundation and Immediate Past Chairman of the Public Broadcasting Service (PBS). James Narduzzi is Dean of the University of Richmond's School of Continuing Studies.…

  13. 77 FR 58773 - Drawbridge Operation Regulations; James River, Newport News, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; James River, Newport News, VA AGENCY... James River, mile 5.0, at Newport News, VA. The deviation is necessary to facilitate the structural... regular operating schedule, the US 17/258 Bridge over the James River, mile 5.0, at Newport News, VA...

  14. From Father to Son: Generative Care and Gradual Conversion in William James's Writing of "The Varieties"

    ERIC Educational Resources Information Center

    Bridgers, Lynn; Snarey, John R.

    2003-01-01

    Using a historical and biographical, then developmental, approach, this article examines William James's spiritual family history by reviewing key events in the life of his father, Henry James, Sr. It pays particular attention to Henry Sr's tumultuous relationship with his own father, William James of Albany, and Henry Sr's subsequent conversion…

  15. Environmental Assessment on the leasing of the Strategic Petroleum Reserve, St. James Terminal, St. James Parish, Louisiana

    SciTech Connect

    1995-01-01

    The US Department of Energy (DOE) proposes to lease the Strategic Petroleum Reserve`s (SPR) St. James Terminal to private industry. The St. James Terminal consists of six storage tanks, a pumping station, two maine docks and ancillary facilities. DOE believes that the St. James Terminal presents an opportunity to establish a government- industry arrangement that could more effectively use this asset to serve the nations`s oil distribution needs, reduce the operational cost of the SPR, and provide a source of revenue for the Government. DOE solicited interest in leasing its distribution facilities in a notice published March 16, 1994. In response, industry has expressed interest in leasing the St. James Terminal, as well as several DOE pipelines, to enhance the operation of its own facilities or to avoid having to construct new ones. Under such a lease, industry use would be subordinate to DOE use in the event of a national energy emergency. This Environmental Assessment describes the proposed leasing operation, its alternatives, and potential environmental impacts. Based on this analyses, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA) OF 1969 and has issued the Finding of No Significant Impact (FONSI).

  16. Shuttle imaging radar views the Earth from Challenger: The SIR-B experiment

    NASA Technical Reports Server (NTRS)

    Ford, J. P.; Cimino, J. B.; Holt, B.; Ruzek, M. R.

    1986-01-01

    In October 1984, SIR-B obtained digital image data of about 6.5 million km2 of the Earth's surface. The coverage is mostly of selected experimental test sites located between latitudes 60 deg north and 60 deg south. Programmed adjustments made to the look angle of the steerable radar antenna and to the flight attitude of the shuttle during the mission permitted collection of multiple-incidence-angle coverage or extended mapping coverage as required for the experiments. The SIR-B images included here are representative of the coverage obtained for scientific studies in geology, cartography, hydrology, vegetation cover, and oceanography. The relations between radar backscatter and incidence angle for discriminating various types of surfaces, and the use of multiple-incidence-angle SIR-B images for stereo measurement and viewing, are illustrated with examples. Interpretation of the images is facilitated by corresponding images or photographs obtained by different sensors or by sketch maps or diagrams.

  17. A New SIR-Based Sigmoid Power Control Game in Cognitive Radio Networks

    PubMed Central

    Al-Gumaei, Yousef Ali; Noordin, Kamarul Ariffin; Reza, Ahmed Wasif; Dimyati, Kaharudin

    2014-01-01

    Interference resulting from Cognitive Radios (CRs) is the most important aspect of cognitive radio networks that leads to degradation in Quality of Service (QoS) in both primary and CR systems. Power control is one of the efficient techniques that can be used to reduce interference and satisfy the Signal-to-Interference Ratio (SIR) constraint among CRs. This paper proposes a new distributed power control algorithm based on game theory approach in cognitive radio networks. The proposal focuses on the channel status of cognitive radio users to improve system performance. A new cost function for SIR-based power control via a sigmoid weighting factor is introduced. The existence of Nash Equilibrium and convergence of the algorithm are also proved. The advantage of the proposed algorithm is the possibility to utilize and implement it in a distributed manner. Simulation results show considerable savings on Nash Equilibrium power compared to relevant algorithms while reduction in achieved SIR is insignificant. PMID:25286044

  18. A new SIR-based sigmoid power control game in cognitive radio networks.

    PubMed

    Al-Gumaei, Yousef Ali; Noordin, Kamarul Ariffin; Reza, Ahmed Wasif; Dimyati, Kaharudin

    2014-01-01

    Interference resulting from Cognitive Radios (CRs) is the most important aspect of cognitive radio networks that leads to degradation in Quality of Service (QoS) in both primary and CR systems. Power control is one of the efficient techniques that can be used to reduce interference and satisfy the Signal-to-Interference Ratio (SIR) constraint among CRs. This paper proposes a new distributed power control algorithm based on game theory approach in cognitive radio networks. The proposal focuses on the channel status of cognitive radio users to improve system performance. A new cost function for SIR-based power control via a sigmoid weighting factor is introduced. The existence of Nash Equilibrium and convergence of the algorithm are also proved. The advantage of the proposed algorithm is the possibility to utilize and implement it in a distributed manner. Simulation results show considerable savings on Nash Equilibrium power compared to relevant algorithms while reduction in achieved SIR is insignificant. PMID:25286044

  19. Structural Insights into Intermediate Steps in the Sir2 Deacetylation Reaction

    SciTech Connect

    Hawse, William F.; Hoff, Kevin G.; Fatkins, David G.; Daines, Alison; Zubkova, Olga V.; Schramm, Vern L.; Zheng, Weiping; Wolberger, Cynthia

    2010-07-22

    Sirtuin enzymes comprise a unique class of NAD{sup +}-dependent protein deacetylases. Although structures of many sirtuin complexes have been determined, structural resolution of intermediate chemical steps are needed to understand the deacetylation mechanism. We report crystal structures of the bacterial sirtuin, Sir2Tm, in complex with an S-alkylamidate intermediate, analogous to the naturally occurring O-alkylamidate intermediate, and a Sir2Tm ternary complex containing a dissociated NAD{sup +} analog and acetylated peptide. The structures and biochemical studies reveal critical roles for the invariant active site histidine in positioning the reaction intermediate, and for a conserved phenylalanine residue in shielding reaction intermediates from base exchange with nicotinamide. The new structural and biochemical studies provide key mechanistic insight into intermediate steps of the Sir2 deacetylation reaction.

  20. Space Shuttle Columbia views the world with imaging radar: The SIR-A experiment

    NASA Technical Reports Server (NTRS)

    Ford, J. P.; Cimino, J. B.; Elachi, C.

    1983-01-01

    Images acquired by the Shuttle Imaging Radar (SIR-A) in November 1981, demonstrate the capability of this microwave remote sensor system to perceive and map a wide range of different surface features around the Earth. A selection of 60 scenes displays this capability with respect to Earth resources - geology, hydrology, agriculture, forest cover, ocean surface features, and prominent man-made structures. The combined area covered by the scenes presented amounts to about 3% of the total acquired. Most of the SIR-A images are accompanied by a LANDSAT multispectral scanner (MSS) or SEASAT synthetic-aperture radar (SAR) image of the same scene for comparison. Differences between the SIR-A image and its companion LANDSAT or SEASAT image at each scene are related to the characteristics of the respective imaging systems, and to seasonal or other changes that occurred in the time interval between acquisition of the images.

  1. Study on the threshold of a stochastic SIR epidemic model and its extensions

    NASA Astrophysics Data System (ADS)

    Zhao, Dianli

    2016-09-01

    This paper provides a simple but effective method for estimating the threshold of a class of the stochastic epidemic models by use of the nonnegative semimartingale convergence theorem. Firstly, the threshold R0SIR is obtained for the stochastic SIR model with a saturated incidence rate, whose value is below 1 or above 1 will completely determine the disease to go extinct or prevail for any size of the white noise. Besides, when R0SIR > 1 , the system is proved to be convergent in time mean. Then, the threshold of the stochastic SIVS models with or without saturated incidence rate are also established by the same method. Comparing with the previously-known literatures, the related results are improved, and the method is simpler than before.

  2. Analysis of epidemic spreading of an SIRS model in complex heterogeneous networks

    NASA Astrophysics Data System (ADS)

    Li, Chun-Hsien; Tsai, Chiung-Chiou; Yang, Suh-Yuh

    2014-04-01

    In this paper, we study the spreading of infections in complex heterogeneous networks based on an SIRS epidemic model with birth and death rates. We find that the dynamics of the network-based SIRS model is completely determined by a threshold value. If the value is less than or equal to one, then the disease-free equilibrium is globally attractive and the disease dies out. Otherwise, the disease-free equilibrium becomes unstable and in the meantime there exists uniquely an endemic equilibrium which is globally asymptotically stable. A series of numerical experiments are given to illustrate the theoretical results. We also consider the SIRS model in the clustered scale-free networks to examine the effect of network community structure on the epidemic dynamics.

  3. Analysis of multiple incidence angle SIR-B data for determining forest stand characteristics

    NASA Technical Reports Server (NTRS)

    Hoffer, R. M.; Lozano-Garcia, D. F.; Gillespie, D. D.; Mueller, P. W.; Ruzek, M. J.

    1986-01-01

    For the first time in the U.S. space program, digital synthetic aperture radar (SR) data were obtained from different incidence angles during Space Shuttle Mission 41-G. Shuttle Imaging Radar-B (SIR-B) data were obtained at incidence angles of 58 deg., 45 deg., and 28 deg., on October 9, 10, and 11, 1984, respectively, for a predominantly forested study area in northern Florida. Cloud-free LANDSAT Thematic Mapper (T.M.) data were obtained over the same area on October 12. The SIR-B data were processed and then digitally registered to the LANDSAT T.M. data by scientists at the Jet Propulsion Laboratory. This is the only known digitally registered SIR-B and T.M. data set for which the data were obtained nearly simultaneously. The data analysis of this information is discussed.

  4. An exploitation of coregistered SIR-A, Seasat and Landsat images

    NASA Technical Reports Server (NTRS)

    Rebillard, P.; Nguyen, T. P.

    1983-01-01

    Multispectral registration and classification of SIR-A, Seasat SAR, and Landsat MSS data is presented over two playas located in the northeastern Algerian Sahara. A supervised classification was made over six classes: salt, palm trees, dunes, limestones, gypsum and sand. The best classification is obtained by using all of the data. The images using radar only misclassify trees and salt, limestone and dunes, gypsum and dunes. Landsat only gives a good map but lacks the roughness information contained in the radar data. The Landsat/SIR-A combination gives a better classification than the Landsat/Seasat combination. Density number histograms computed within several classes on the Seasat and SIR-A data show the misclassification is mainly due to the Seasat data.

  5. BOREAS RSS-15 SIR-C and Landsat TM Biomass and Landcover Maps of the NSA

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Ranson, K. Jon

    2000-01-01

    As part of BOREAS, the RSS-15 team conducted an investigation using SIR-C, X-SAR, and Landsat TM data for estimating total above-ground dry biomass for the SSA and NSA modeling grids and component biomass for the SSA. Relationships of backscatter to total biomass and total biomass to foliage, branch, and bole biomass were used to estimate biomass density across the landscape. The procedure involved image classification with SAR and Landsat TM data and development of simple mapping techniques using combinations of SAR channels. For the SSA, the SIR-C data used were acquired on 06-Oct-1994, and the Landsat TM data used were acquired on 02-Sep-1995. The maps of the NSA were developed from SIR-C data acquired on 13-Apr-1994. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  6. The Spaceborne Imaging Radar program: SIR-C - The next step toward EOS

    NASA Astrophysics Data System (ADS)

    Evans, Diane; Elachi, Charles; Cimino, Jobea

    1987-10-01

    The NASA Shuttle Imaging Radar SIR-C experiments will investigate earth surface and environment phenomena to deepen understanding of terra firma, biosphere, hydrosphere, cryosphere, and atmosphere components of the earth system, capitalizing on the observational capabilities of orbiting multiparameter radar sensors alone or in combination with other sensors. The SIR-C sensor encompasses an antenna array, an exciter, receivers, a data-handling network, and the ground SAR processor. It will be possible to steer the antenna beam electronically, so that the radar look angle can be varied.

  7. Global stability and optimal control of an SIRS epidemic model on heterogeneous networks

    NASA Astrophysics Data System (ADS)

    Chen, Lijuan; Sun, Jitao

    2014-09-01

    In this paper, we consider an SIRS epidemic model with vaccination on heterogeneous networks. By constructing suitable Lyapunov functions, global stability of the disease-free equilibrium and the endemic equilibrium of the model is investigated. Also we firstly study an optimally controlled SIRS epidemic model on complex networks. We show that an optimal control exists for the control problem. Finally some examples are presented to show the global stability and the efficiency of this optimal control. These results can help in adopting pragmatic treatment upon diseases in structured populations.

  8. The Spaceborne Imaging Radar program: SIR-C - The next step toward EOS

    NASA Technical Reports Server (NTRS)

    Evans, Diane; Elachi, Charles; Cimino, Jobea

    1987-01-01

    The NASA Shuttle Imaging Radar SIR-C experiments will investigate earth surface and environment phenomena to deepen understanding of terra firma, biosphere, hydrosphere, cryosphere, and atmosphere components of the earth system, capitalizing on the observational capabilities of orbiting multiparameter radar sensors alone or in combination with other sensors. The SIR-C sensor encompasses an antenna array, an exciter, receivers, a data-handling network, and the ground SAR processor. It will be possible to steer the antenna beam electronically, so that the radar look angle can be varied.

  9. A demonstration of stereophotogrammetry with combined SIR-B and Landsat TM images

    NASA Technical Reports Server (NTRS)

    Bloom, Arthur L.; Fielding, Eric J.; Fu, Xiu-Yen

    1988-01-01

    Shuttle Imaging Radar-B (SIR-B) and Landsat Thematic Mapper (TM) images can be viewed stereoscopically if the illumination geometries are compatible. To create the stereoscopic effect points must be coregistered. Simplified stereophotogrammetric equations permit the height of an object above a reference plane to be crudely calculated from the target offset toward the SIR-B radar antenna with reference to its position on a TM image. Precision is limited by pixel resolution and target correlation. Future spaceborne imaging radar missions will offer the potential for topographic mapping in many areas where TM coverage is available.

  10. Delineation of major geologic structures in Turkey using SIR-B data

    NASA Technical Reports Server (NTRS)

    Toksoz, M. N.; Pettengill, G. H.; Ford, P.; Gulen, L.

    1984-01-01

    Shuttle Imaging Radar-B (SIR-B) images of well mapped segments of major faults, such as the North Anatolian Fault (NAF) and East Anatolian Fault (EAF) will be studied to identify the prominent signatures that characterize the fault zones for those specific regions. The information will be used to delineate the unmapped fault zones in areas with similar geological and geomorphological properties. The data obtained from SIR-B images will be compared and correlated with the LANDSAT thematic mapper and seismicity alignments based on well constrained earthquake epicenters.

  11. 77 FR 21150 - Requested Administrative Waiver of the Coastwise Trade Laws: Vessel SIR MARTIN II; Invitation for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-09

    ... Maritime Administration Requested Administrative Waiver of the Coastwise Trade Laws: Vessel SIR MARTIN II... and all documents entered into this docket is available on the World Wide Web at http://www... the vessel SIR MARTIN II is: Intended Commercial Use of Vessel: ``Day charter up to 6 passengers...

  12. Satanic agency and mesmerism reviewed--James Braid.

    PubMed

    Tinterow, M M

    1993-07-01

    Satanic Agency and Mesmerism Reviewed, In A Letter To The Reverend H. Mc. Neile of Liverpool, is a 12-page book in which James Braid laid the foundation stone of medical hypnotism. The present copy of this book is said to be unique. No other copy of this book has been found in the United States or England. The book, which is in the Rare Book Collection at the Wichita State University Ablah Library, came from the library of Albert Moll. The age of mesmerism or animal magnetism was brought to a close by James Braid, and in this book, his first work on mesmerism. Braid used the word hypnotism to replace mesmerism. His first use of the word occurred in this work and not, as is generally believed, in his later work, Neurypnology. PMID:8368194

  13. STS-69 Mission Specialist James H. Newman suits up

    NASA Technical Reports Server (NTRS)

    1995-01-01

    STS-69 Mission Specialist James H. Newman dons his launch/entry suit in the Operations and Checkout Building with assistance from a suit technician. Note that Newman's name tag reads Pluto. The STS-69 crew has dubbed itself the Dog Crew II, continuing a spirit of camaraderie that began on an earlier flight, STS-53, on which STS-69 astronauts James Voss and David Walker were crew members. Each of the STS-69 crew members adopted a dog-theme name, and the crew is even sporting a Dog Crew II patch along with the traditional mission emblem. After donning their launch/ entry suits, Newman and four fellow crewmembers will depart for Launch Pad 39A, where the Space Shuttle Endeavour awaits liftoff during a two and a half hour window opening at 11:09 a.m. EDT.

  14. Swyer-James-Macleod Syndrome: A Rare Entity.

    PubMed

    Singh, Urvinderpal; Vidhu; Aditi; Singh, Kulbir; Singh, Ashrafjit

    2015-01-01

    Swyer-James-MacLeod syndrome is a radiological entity characterised by hyperlucency of one or more lobes or of the entire lung associated with decreased number and diameter of ipsilateral peripheral pulmonary vessels resulting in difficult visibility of the arterial network, and unobstructed bronchial system. We report the case of a 12-year-old girl who presented with chief complaint of pain in the chest. Chest radiograph (postero-anterior view) showed hyperlucent left lung field with increased lung volume and shift of the mediastinum to the right side. Contrast-enhanced computed tomography (CECT) of the chest showed hyperlucency and diminished vascularity in the upper lobe and lingula of left lung with hyperinflation of the pulmonary parenchyma. On the basis of clinical and radiological findings, the patient was diagnosed to have Swyer-James-MacLeod syndrome. PMID:26591973

  15. STS-90 Payload Specialist James Pawelczyk arrives at KSC

    NASA Technical Reports Server (NTRS)

    1998-01-01

    STS-90 Payload Specialist James Pawelczyk, Ph.D., tosses mission hats to his two children shortly after arrival at Kennedy Space Center's Shuttle Landing Facility. The crew of STS-90 arrived at KSC in preparation for their mission, scheduled for launch from KSC's Launch Pad 39B on April 16 at 2:19 p.m. EDT. The flight of Neurolab is scheduled to last nearly 17 days.

  16. Physical Characterization of TNOs with the James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Parker, Alex; Pinilla-Alonso, Noemi; Santos-Sanz, Pablo; Stansberry, John; Alvarez-Candal, Alvaro; Bannister, Michele; Benecchi, Susan; Cook, Jason; Fraser, Wesley; Grundy, Will; Guilbert, Aurelie; Merline, Bill; Moullet, Arielle; Mueller, Michael; Olkin, Cathy; Ragozzine, Darin

    2016-01-01

    Studies of the physical properties of trans-Neptunian objects (TNOs) are a powerful probe into the processes of planetesimal formation and solar system evolution. James Webb Space Telescope (JWST) will provide unique new capabilities for such studies. Here, we outline where the capabilities of JWST open new avenues of investigation, potentially valuable observations and surveys, and conclude with a discussion of community actions that may serve to enhance the eventual science return of JWST's TNO observations.

  17. Seasonal Variations of the James Webb Space Telescope Orbital Dynamics

    NASA Technical Reports Server (NTRS)

    Brown, Jonathan; Petersen, Jeremy; Villac, Benjamin; Yu, Wayne

    2015-01-01

    While spacecraft orbital variations due to the Earth's tilt and orbital eccentricity are well-known phenomena, the implications for the James Webb Space Telescope present unique features. We investigate the variability of the observatory trajectory characteristics, and present an explanation of some of these effects using invariant manifold theory and local approximation of the dynamics in terms of the restricted three-body problem.

  18. A Scientific Revolution: The Hubble and James Webb Space Telescopes

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2011-01-01

    Astronomy is going through a scientific revolution, responding to a Rood of data from the Hubble Space Telescope, other space missions, and large telescopes on the ground. In this talk, Dr. Gardner will discuss some of the most important astronomical discoveries of the last 10 years, and the role that space telescopes have played in those discoveries. The next decade looks equally bright with the newly refurbished Hubble and the promise of its successor, the James Webb Space Telescope.

  19. James Joyce and Molly Bloom: reflections on their relationship.

    PubMed

    Jacobs, Theodore J

    2002-01-01

    The relationship between James Joyce and his memorable creation, Molly Bloom, is explored in relation to Joyce's remarkable creativity and various factors that may have contributed to it. A character forged primarily out of Joyce's perceptions of his wife Nora and memories of his mother, Molly also contains aspects of Joyce's warded-off and wished-for self-representation. A focus on both biographical and dynamic contributions to the creation of Molly helps to illuminate aspects of Joyce's psychology. PMID:12580331

  20. Astronauts James Lovell and Frank Borman during preflight physical

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Dr. Charles A. Berry, Chief of the Manned Spacecraft Center (MSC) Medical Programs, checks Astronaut James A. Lovell Jr., Gemini 7 prime crew pilot, follwoing workout on exercise machine. Results will be compared with those obtained during space flight for evaluation (60602); Astronaut Frank Borman, Gemini 7 command pilot, sits as two scalp electrodes are attached to his head. The electrodes will allow doctors to record electrical activity of the astronaut's cerebral cortex during periods of weightlessness (60603).

  1. Observing Exoplanets with the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Clampin Mark

    2011-01-01

    The search for exoplanets and characterization of their properties has seen increasing success over the last few years. In excess of 500 exoplanets are known and Kepler has approx. 1000 additional candidates. Recently, progress has been made in direct imaging planets, both from the ground and in space. This presentation will discuss the history and current state of technology used for such discoveries, and highlight the new capabilities that will be enabled by the James Webb Space Telescope.

  2. Optical Testing of the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Aronstein, David L.

    2014-01-01

    The James Webb Space Telescope (JWST) will be a large infrared telescope with a 6.5-meter primary mirror, working to a 2018 launch date. Ground testing for the JWST will occur in two test campaigns, at NASAs Goddard Space Flight Center and Johnson Space Center. The talk describes the JWST and its optical ground testing, highlighting the roles of many of the University of Rochester Institute of Optics' alumni as well as current faculty and students.

  3. STS-104 MS James Reilly inside Atlantis during TCDT

    NASA Technical Reports Server (NTRS)

    2001-01-01

    KENNEDY SPACE CENTER, Fla. -- STS-104 Mission Specialist James F. Reilly checks out equipment inside Atlantis. He and other crew members are taking part in a simulated countdown exercise, which is part of Terminal Countdown Demonstration Test activities. The launch of Atlantis on mission STS-104 is scheduled July 12. The mission is the 10th flight to the International Space Station and carries the Joint Airlock Module and High Pressure Gas Assembly.

  4. Astronaut James Lovell prior to entering Gemini Mission Simulator

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Astronaut James A. Lovell Jr., prime crew command pilot of the Gemini 12 space flight, in Building 5, Mission Simulation and Training Facility, Houston, Texas. This photo was taken prior to his entering the Gemini Mission Simulator for flight training (45578); Astronaut Lovell (right) talks with Burton M. Gifford (left) and Duane K. Mosel (center), both with the Simulation Branch, Flight Crew Support Division (45579); Astronaut Lovell prepares to enter Gemini Mission Simulator (45580).

  5. Green Summer and Icy Winter in James Bay

    NASA Technical Reports Server (NTRS)

    2001-01-01

    One year ago, in late February 2000, MISR began acquiring Earth imagery. Its 'first light' images showed a frozen James Bay in the Ontario-Quebec region of Canada. These more recent nadir-camera views of the same area illuminate stark contrasts between summer and winter. The left-hand image was acquired on August 9, 2000 (Terra orbit 3427), and the right-hand image is from January 16, 2001 (Terra orbit 5757).

    James Bay lies at the southern end of Hudson Bay. It is named for the English explorer Thomas James, who first explored the area in 1631 while searching for the Northwest Passage. Visible in these images are some of the many rivers that flow into the bay; starting at the southern tip and moving clockwise on the western side are the Harricana, Moose, Albany, and Attawapiskat. The latter enters the bay just to the west of the large, crescent-shaped Akimiski Island.

    MISR was built and is managed by NASA's Jet Propulsion Laboratory, Pasadena, CA, for NASA's Office of Earth Science, Washington, DC. The Terra satellite is managed by NASA's Goddard Space Flight Center, Greenbelt, MD. JPL is a division of the California Institute of Technology.

  6. SIR-B synthetic aperture radar image of California taken during 41-G mission

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Image of Mt. Shasta volcano (conical peak at left) in northern California was acquired by the Shuttle Imaging Radar-B (SIR-B) during the STS 41-G mission aboard the shuttle Challenger. Mt. Shasta is surrounded by bright-appearing lava flows, the Shasta valley (left) and Squaw Valley (right).

  7. DEVELOPMENT OF ENZYME-LINKED IMMUNOSORBENT ASSAYS FOR RESIDUE ANALYSIS OF DIFLUBENZURON AND BAY SIR 8514

    EPA Science Inventory

    Three enzyme-linked immunosorbent assays (ELISA's) were developed for the benzoylphenylurea insect growth regulators (IGRs) diflubenzuron, BAY SIR 8514, and some of their analogues. All three ELISA's were based on antibodies raised against an N-carboxypropyl hapten of diflubenzur...

  8. Bulimia: A Comment on an Old Case Report by Sir Thomas Browne

    PubMed Central

    Higgins, Gerald L.

    1989-01-01

    This paper offers a brief review of recent literature on the incidence and age of onset of bulimia in the light of a 17th century description of a female centenarian with bulimia, together with a brief account of the physician, Sir Thomas Browne (1605-1682), and the etymology and early usage of the term. PMID:21248899

  9. 90Sr content in 90Y-labeled SIR-spheres and Zevalin.

    PubMed

    Metyko, John; Erwin, William; Poston, John; Jimenez, Sandra

    2014-11-01

    Three different 90Y internally administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures atMD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize 90Y-labeled microspheres, while Zevalin is an 90Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from 90Y production methods. The 90Y in SIR-Spheres and Zevalin are produced from a 90Sr/90Y generator, which leaves measurable quantities of 90Sr in the final product. TheraSphere 90Y is produced in a nuclear reactor which results in a large number of impurities, most notably 88Y and 91Y. Product information sheets reference these impurities with specific limits given. These limits represent a tiny fraction of the total product activity, and in the case of TheraSphere and SIR-Spheres gamma-emitting impurities, this has been verified in the literature. An analysis of 90Sr impurities in SIR-Spheres and Zevalin is presented in this paper. Impurity quantities were found to be within the vendors’ documented limits. PMID:25272027

  10. Extended longevity and survivorship during amino-acid starvation in a Drosophila Sir2 mutant heterozygote.

    PubMed

    Slade, Jennifer D; Staveley, Brian E

    2016-05-01

    The regulation of energy homeostasis is pivotal to survive periods of inadequate nutrition. A combination of intricate pathways and proteins are responsible for maximizing longevity during such conditions. The sirtuin deacetylase Sir2 is well conserved from single-celled yeast to mammals, and it controls a number of downstream targets that are active during periods of extreme stress. Overexpression of Sir2 has been established to enhance survival of a number of model organisms undergoing calorie restriction, during which insulin receptor signalling (IRS) is reduced, a condition that itself can enhance survivorship during starvation. Increased Sir2 expression and reduced IRS result in an increase in the activity of the transcription factor foxo, an advantageous activation during stress but lethal when overly active. We have found that a lowered gene dosage of Sir2, in mutant heterozygotes, can extend normal longevity and greatly augment survivorship during amino-acid starvation in Drosophila. Additionally, these mutants, in either heterozygous or homozygous form, do not appear to have any disadvantageous effects upon development or cell growth of the organism unlike IRS mutants. These results may advance the understanding of the biological response to starvation and allow for the development of a model organism to mimic the ability of individuals to tolerate nutrient deprivation. PMID:27074822

  11. The Burt Controversy: An Essay Review of Hearnshaw's and Joynson's Biographies of Sir Cyril Burt.

    ERIC Educational Resources Information Center

    Hattie, John

    1991-01-01

    Two biographies of Sir Cyril Burt argue the case of Britain's most famous psychologist, accused of academic fraud relating to his studies of IQ and heredity. The verdict is unclear, but lessons abound for social science researchers, students, universities, and investigators of research fraud. Contains 62 references. (SV)

  12. Vision and Leadership in Educational Administration: Sir George White of Norwich (1840-1912)

    ERIC Educational Resources Information Center

    Sperandio, Jill

    2006-01-01

    This article considers the usefulness of current models of leadership in change situations for an analysis of a historical case study of educational leadership. It uses the life of Sir George White (1842-1912) and his leadership in the field of education in Norwich and at the national level in the UK to examine the nature of effective leadership…

  13. Stochastic lattice gas model describing the dynamics of the SIRS epidemic process

    NASA Astrophysics Data System (ADS)

    de Souza, David R.; Tomé, Tânia

    2010-03-01

    We study a stochastic process describing the onset of spreading dynamics of an epidemic in a population composed of individuals of three classes: susceptible (S), infected (I), and recovered (R). The stochastic process is defined by local rules and involves the following cyclic process: S → I → R → S (SIRS). The open process S → I → R (SIR) is studied as a particular case of the SIRS process. The epidemic process is analyzed at different levels of description: by a stochastic lattice gas model and by a birth and death process. By means of Monte Carlo simulations and dynamical mean-field approximations we show that the SIRS stochastic lattice gas model exhibit a line of critical points separating the two phases: an absorbing phase where the lattice is completely full of S individuals and an active phase where S, I and R individuals coexist, which may or may not present population cycles. The critical line, that corresponds to the onset of epidemic spreading, is shown to belong in the directed percolation universality class. By considering the birth and death process we analyze the role of noise in stabilizing the oscillations.

  14. Sir Fred Clarke: A Reappraisal of His Early Years 1880-1911

    ERIC Educational Resources Information Center

    Clarke, Claudia

    2006-01-01

    Frank Mitchell's biography of Sir Fred Clarke, one of the most influential British educationists of the first half of the twentieth century, was published in 1967. This article by Claudia Clarke draws upon previously unknown material and her own recollections to provide new insights into her father's personal and professional lives and to modify…

  15. Fathers' Role as Attachment Figures: An Interview with Sir Richard Bowlby

    ERIC Educational Resources Information Center

    Newland, Lisa A.; Coyl, Diana D.

    2010-01-01

    Sir Richard Bowlby, son of John Bowlby, has carried on his father's work by lecturing and writing on the topic of attachment theory. He has initiated and maintained international connections with researchers, practitioners and agencies in the field of child development, and has produced training videos to more widely disseminate information about…

  16. SirT1 gain-of-function increases energy efficiency and prevents diabetes in mice

    PubMed Central

    Banks, Alexander S.; Kon, Ning; Knight, Colette; Matsumoto, Michihiro; Gutiérrez-Juárez, Roger; Rossetti, Luciano; Gu, Wei; Accili, Domenico

    2011-01-01

    Summary In yeast, worms and flies, an extra copy of the gene encoding the Sirtuin Sir2 increases metabolic efficiency, as does administration of polyphenols like resveratrol, thought to act through Sirtuins. But evidence that Sirtuin gain-of-function results in increased metabolic efficiency in mammals is limited. We generated transgenic mice with moderate overexpression of SirT1, designed to mimic the Sirtuin gain-of-function that improves metabolism in C.elegans. These mice exhibit normal insulin sensitivity, but decreased food intake and locomotor activity, resulting in decreased energy expenditure. However, in various models of insulin resistance and diabetes, SirT1 transgenics display improved glucose tolerance due to decreased hepatic glucose production and increased adiponectin levels, without changes in body weight or composition. We conclude that SirT1 gain-of-function primes the organism for metabolic adaptation to insulin resistance, increasing hepatic insulin sensitivity and decreasing whole-body energy requirements. These findings have important implications for Sirtuin-based therapies in humans. PMID:18840364

  17. Taking Lulu Seriously: What We Can Learn from "To Sir with Love"

    ERIC Educational Resources Information Center

    Shouse, Roger C.

    2005-01-01

    Purpose: This paper seeks to examine ways in which the film "To Sir with Love" illustrates several longstanding issues and tensions related to the sociology of education. It is also aims to show how this film (and, by implication, other popular films) can be used to advance understanding among students of educational leadership, organization…

  18. Evaluation of SIR-B data for identifying rainfall event occurrence and intensity

    NASA Technical Reports Server (NTRS)

    Garofalo, D.; Cooper, J. N.; Everett, J. R.; Warnick, L. J.; Wynn, L. H.; Sheffield, C.; Ruth, M.; Perrine, R.; Estep, K.

    1984-01-01

    The utility of shuttle imaging radar-B (SIR-B) data for the detection and measurement of rainfall events is to be investigated. The investigation is described along with the approach for data acquisition, handling, and analysis. Anticipated results are also considered. The CROPCAST rainfall estimation technique is discussed.

  19. Language as Sensuous Action: Sir Richard Paget, Kenneth Burke, and Gesture-Speech Theory

    ERIC Educational Resources Information Center

    Hawhee, Debra

    2006-01-01

    This somatic genealogy of Dramatism's core terms--symbolic action, attitude, identification--argues for the importance of keeping rhetoric, rhetorical theory, and rhetorical pedagogy more closely tied to bodies that generate, induce, and respond to rhetoric. It does so by examining Burke's use of Sir Richard Paget's theory that spoken language…

  20. The man behind the DNA fingerprints: an interview with Professor Sir Alec Jeffreys

    PubMed Central

    2013-01-01

    In this interview we talk with Professor Sir Alec Jeffreys about DNA fingerprinting, his wider scientific career, and the past, present and future of forensic DNA applications. The podcast with excerpts from this interview is available at: http://www.biomedcentral.com/biome/alec-jeffreys. PMID:24245655

  1. Sir Hermann Bondi: A journey through his life and the early endeavours of Europe into space

    NASA Astrophysics Data System (ADS)

    Sterken, V. J.

    2007-06-01

    This paper highlights the life, work and personality of Sir Hermann Bondi, with an emphasis on his years as Director General (DG) of the European Space Research Organisation (ESRO), the predecessor of ESA. Born in Austria, but being at his ease in Cambridge, Sir Hermann Bondi has had a varying and impressive career as a lecturer, researcher, manager and advisor in many fields like cosmology, radar technology, space research, energy and defence. He became well known for the Steady State theory of the Universe, a theory that was disproved by the Big Bang theory but that caused a lot of fruitful discussions in the scientific world. As a DG of ESRO, Sir Hermann Bondi has proven his intellectual, organisational and communication capabilities while being one of the main players in helping the rise of a European space effort to a success. Apart from his work, Sir Hermann Bondi loved to travel, to ski and to climb in the mountains. He was also an active member and later president of the British Humanist Association, he was influenced by Popper's science philosophy and he stimulated science to be brought to the public. He was known as a very strong personality, which impressed many people who have met him.

  2. Tolerance of Sir1p/origin recognition complex-dependent silencing for enhanced origin firing at HMRa.

    PubMed

    McConnell, Kristopher H; Müller, Philipp; Fox, Catherine A

    2006-03-01

    The HMR-E silencer is a DNA element that directs the formation of silent chromatin at the HMRa locus in Saccharomyces cerevisiae. Sir1p is one of four Sir proteins required for silent chromatin formation at HMRa. Sir1p functions by binding the origin recognition complex (ORC), which binds to HMR-E, and recruiting the other Sir proteins (Sir2p to -4p). ORCs also bind to hundreds of nonsilencer positions distributed throughout the genome, marking them as replication origins, the sites for replication initiation. HMR-E also acts as a replication origin, but compared to many origins in the genome, it fires extremely inefficiently and late during S phase. One postulate to explain this observation is that ORC's role in origin firing is incompatible with its role in binding Sir1p and/or the formation of silent chromatin. Here we examined a mutant HMR-E silencer and fusions between robust replication origins and HMR-E for HMRa silencing, origin firing, and replication timing. Origin firing within HMRa and from the HMR-E silencer itself could be significantly enhanced, and the timing of HMRa replication during an otherwise normal S phase advanced, without a substantial reduction in SIR1-dependent silencing. However, although the robust origin/silencer fusions silenced HMRa quite well, they were measurably less effective than a comparable silencer containing HMR-E's native ORC binding site. PMID:16479013

  3. Effect of iron on the expression of sirR and sitABC in biofilm-associated Staphylococcus epidermidis

    PubMed Central

    Massonet, Caroline; Pintens, Valerie; Merckx, Rita; Anné, Jozef; Lammertyn, Elke; Van Eldere, Johan

    2006-01-01

    Background Different gene expression patterns correlate with the altered phenotype in biofilm-associated bacteria. Iron and iron-linked genes are thought to play a key-role in biofilm formation. The expression of Fe-linked genes (sirR, sitABC operon) in Staphylococcus epidermidis, was compared in planktonic versus sessile bacteria in vitro and in vivo in a subcutaneous foreign body rat model. Results In vitro in a Fe-limited environment, the planktonic form of S. epidermidis produces siderophores and grows slower than in Fe-rich environment. The expression of sirR in planktonic bacteria, in vitro, was not different in medium without Fe or with 1 μM FeCl3. High Fe concentrations (25 μM FeCl3) increased expression of sirR transiently during the early phase of incubation. Expression of sitC in vitro, in planktonic bacteria, was inversely correlated with sirR expression in medium with 25 μM FeCl3: sitC expression decreased for the first 3 hours followed by an up regulation. In sessile bacteria in vitro, sirR expression was high and independent of the Fe concentration. The expression of sitC was not inversely correlated to sirR expression. In vivo, expression levels of sirR and of sitABC were high during the initial phase after implantation and, after a transient decrease, remained stable over a period of two weeks. Conclusion Our data suggest that the expression of sirR and the regulatory effect of sirR on the sitABC operon are different in planktonic and sessile bacteria. PMID:17177984

  4. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.

    PubMed

    Palu, Rebecca A S; Thummel, Carl S

    2016-04-01

    SIRT1 is a member of the sirtuin family of NAD+-dependent deacetylases, which couple cellular metabolism to systemic physiology. Although studies in mouse models have defined a central role for SIRT1 in maintaining metabolic health, the molecular mechanisms remain unclear. Here we show that loss of the Drosophila SIRT1 homolog sir2 leads to the age-progressive onset of hyperglycemia, obesity, glucose intolerance, and insulin resistance. Tissue-specific functional studies show that Sir2 is both necessary and sufficient in the fat body (analogous to the mammalian liver) to maintain glucose homeostasis and peripheral insulin sensitivity. Transcriptional profiling of sir2 mutants by RNA-seq revealed a major overlap with genes regulated by the nuclear receptor Hepatocyte Nuclear Factor 4 (HNF4). Consistent with this, Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 mutants, and protein levels for dHNF4 are reduced in sir2 mutant animals. We show that Sir2 exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions. Increasing dHNF4 expression in sir2 mutants is sufficient to rescue their insulin signaling defects, defining this nuclear receptor as an important downstream effector of Sir2 signaling. This study demonstrates that the key metabolic activities of SIRT1 have been conserved through evolution, provides a genetic model for functional studies of phenotypes related to type 2 diabetes, and establishes HNF4 as a critical downstream target by which Sir2 maintains metabolic health. PMID:27058248

  5. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila

    PubMed Central

    Palu, Rebecca A. S.; Thummel, Carl S.

    2016-01-01

    SIRT1 is a member of the sirtuin family of NAD+-dependent deacetylases, which couple cellular metabolism to systemic physiology. Although studies in mouse models have defined a central role for SIRT1 in maintaining metabolic health, the molecular mechanisms remain unclear. Here we show that loss of the Drosophila SIRT1 homolog sir2 leads to the age-progressive onset of hyperglycemia, obesity, glucose intolerance, and insulin resistance. Tissue-specific functional studies show that Sir2 is both necessary and sufficient in the fat body (analogous to the mammalian liver) to maintain glucose homeostasis and peripheral insulin sensitivity. Transcriptional profiling of sir2 mutants by RNA-seq revealed a major overlap with genes regulated by the nuclear receptor Hepatocyte Nuclear Factor 4 (HNF4). Consistent with this, Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 mutants, and protein levels for dHNF4 are reduced in sir2 mutant animals. We show that Sir2 exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions. Increasing dHNF4 expression in sir2 mutants is sufficient to rescue their insulin signaling defects, defining this nuclear receptor as an important downstream effector of Sir2 signaling. This study demonstrates that the key metabolic activities of SIRT1 have been conserved through evolution, provides a genetic model for functional studies of phenotypes related to type 2 diabetes, and establishes HNF4 as a critical downstream target by which Sir2 maintains metabolic health. PMID:27058248

  6. Use of SIR-B multiincidence-angle imagery to study iceberg detectability and offshore ocean feature extraction

    NASA Technical Reports Server (NTRS)

    Gray, A. L.; Princz, J.; Livingstone, C. E.; Hawkins, R. K.; Wong, M.; Pearson, D.; Gower, J.; Mullane, T. F.; Ramseier, R. O.

    1984-01-01

    The Shuttle Imaging Radar B (SIR-B) iceberg experiment is described and expected results are outlined. The specific objectives are: (1) to study the L-band satellite SAR detectability of iceberg targets as a function of incidence angle and observed conditions; (2) to compare L-, X-, and C-band aircraft imagery, and to use this data as a basis for an appropriate simulation of satellite imagery and to compare with SIR-B images; and (3) to determine the possibility of comparive available surface or near surface currents with estimates of the range component of surface current derived from the SIR-B data (IOS experiment).

  7. A debate on the subject "Are SIRS and MODS important entities in the clinical evaluation of patients?" The con position.

    PubMed

    Baue, A E

    2000-12-01

    SIRS, MODS, and MOF are not diseases or even syndromes. They are simply clinical descriptors of people that are sick. They are symptoms and signs of various stages of illness progressing to death in the modern organ supporting ICU. They are catchy, popular acronyms but they cannot be treated specifically, and then only by support of organ functions. To help our patients and improve morbidity and mortality we must focus on specific diseases. Although ventilator associated pneumonia and pancreatitis may both produce an inflammatory response, cytokine-mediator activation and SIRS, they must each be treated in a different way. I believe that SIRS has led us astray. PMID:11131906

  8. James Webb Space Telescope (JWST): The First Light Machine

    NASA Technical Reports Server (NTRS)

    Stahl, Philip

    2009-01-01

    This slide presentation review the mission objective, the organization of the mission planning, the design, and testing of the James Webb Space Telescope (JWST). There is also information about the orbit, in comparison to the Hubble Space Telescope, the mirror design, and the science instruments. Pictures of the full scale mockup of the JWST are given. A brief history of the universe is also presented from the big bang through the formation of galaxies, and the planets, to life itself. One of the goals of the JWST is to search for extra solar planets and then to search for signs of life.

  9. Bollasina Receives 2013 James R. Holton Junior Scientist Award: Response

    NASA Astrophysics Data System (ADS)

    Bollasina, Massimo A.

    2014-08-01

    I am deeply honored to have been selected as this year's recipient of the James R. Holton Junior Scientist Award, and I receive it with heartfelt gratitude and humility. I clearly remember Peter Webster's call announcing the amazing news and how I literally remained speechless and overwhelmed. I would like to express my sincere appreciation to the Atmospheric Sciences section of AGU and the members of the award committee. I am even more appreciative to have been presented this award handed by two outstanding scientists—Peter Webster and Bill Lau—who have remarkably contributed to our understanding of the Asian monsoon and tropical climate, my area of expertise.

  10. Status of the James Webb Space Telescope Observatory

    NASA Technical Reports Server (NTRS)

    Clampin, Mark

    2013-01-01

    The James Webb Space Telescope (JWST) is the largest cryogenic, space telescope ever built, and will address a broad range of scientific goals from first light in the universe and re-ionization, to characterization of the atmospheres of extrasolar planets. Recently, significant progress has been made in the construction of the observatory with the completion of all 21 flight mirrors that comprise the telescope's optical chain, and the start of flight instrument deliveries to the Goddard Space Flight Center. In this paper we discuss the design of the observatory, and focus on the recent milestone achievements in each of the major observatory sub-systems.

  11. Photographic copy of photograph (original print in possession of James ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph (original print in possession of James E. Zelinski, Earth Tech, Huntsville, AL). Photographer unknown. Aerial view (southwest to northeast) of remote sprint launch site #2, nearing completion. The RLOB has been earth-mounded. The limited access sentry station can be seen in the PAR right foreground, behind it are the waste stabilization ponds. Barely discernible is the exclusion area sentry station at the entrance to the sprint field - Stanley R. Mickelsen Safeguard Complex, Remote Sprint Launch Site No. 2, West of Mile Marker 220 on State Route 1, 6.0 miles North of Langdon, ND, Nekoma, Cavalier County, ND

  12. The James Webb Space Telescope (JWST), The First Light Machine

    NASA Technical Reports Server (NTRS)

    Stahl, H. Philip

    2013-01-01

    Scheduled to begin its 10 year mission after 2018, the James Webb Space Telescope (JWST) will search for the first luminous objects of the Universe to help answer fundamental questions about how the Universe came to look like it does today. At 6.5 meters in diameter, JWST will be the world s largest space telescope. This talk reviews science objectives for JWST and how they drive the JWST architecture, e.g. aperture, wavelength range and operating temperature. Additionally, the talk provides an overview of the JWST primary mirror technology development and fabrication status.

  13. Capabilities of the James Webb Space Telescope for Exoplanet Science

    NASA Technical Reports Server (NTRS)

    Clampin, Mark

    2009-01-01

    The James Webb Space Telescope (JWST) is a large aperture (6.5 meter), cryogenic space telescope with a suite of near and mid-infrared instruments covering the wavelength range of 0.6 m to 28 m. JWST s primary science goal is to detect and characterize the first galaxies. It will also study the assembly of galaxies, star formation, and the formation of evolution of planetary systems. We also review the expected scientific performance of the observatory for observations of exosolar planets by means of transit photometry and spectroscopy, and direct coronagraphic imaging.

  14. A Scientific Revolution: The Hubble and James Webb Space Telescopes

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2009-01-01

    Astronomy is going through a scientific revolution, responding to a flood of data from the Hubble Space Telescope, other space missions, and large telescopes on the ground. In this talk, I will discuss the top 10 astronomical discoveries of the last 10 years, and the role that space telescopes have played in those discoveries. The next decade looks equally bright with the newly refurbished Hubble and the promise of its successor, the James Webb Space Telescope. I will describe how Hubble was upgraded and how and why we are building Webb.

  15. A Scientific Revolution: the Hubble and James Webb Space Telescopes

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2011-01-01

    Astronomy is going through a scientific revolution, responding to a flood of data from the Hubble Space Telescope, other space missions, and large telescopes on the ground. In this talk, I will discuss some of the most important astronomical discoveries of the last 10 years, and the role that space telescopes have played in those discoveries. The next decade looks equally bright with the newly refurbished Hubble and the promise of its successor, the James Webb Space Telescope. I will describe how Hubble was upgraded and how and why we are building Webb.

  16. A Scientific Revolution: the Hubble and James Webb Space Telescopes

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2012-01-01

    Astronomy is going through a scientific revolution, responding to a flood of data from the Hubble Space Telescope, other space missions, and large telescopes on the ground. In this talk, I will discuss some of the most important astronomical discoveries of the last IO years, and the role that space telescopes have played in those discoveries. The next decade looks equally bright with the newly refurbished Hubble and the promise of its successor, the James Webb Space Telescope. I will describe how Hubble was upgraded and how and why we are building Webb.

  17. A Scientific Revolution: The Hubble and James Webb Space Telescopes

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan

    2011-01-01

    Astronomy is going through a scientific revolution, responding to a flood of data from the Hubble Space Telescope, other space missions, and large telescopes on the ground. In this talk, I will discuss some of the most important astronomical discoveries of the last 10 years, and the role that space telescopes have played in those discoveries. The next decade looks equally bright with the newly refurbished Hubble and the promise of its successor, the James Webb Space Telescope. I will describe how Hubble was upgraded and how and why we are building Webb.

  18. James F. Crow: His Life in Public Service

    PubMed Central

    Abrahamson, Seymour

    2012-01-01

    The readers of this journal may well be aware of Professor Crow’s scientific achievements and his role as the editor of Perspectives. In addition, for many thousands of students at the University of Wisconsin over many generations, James F. Crow was one of the most memorable teachers at both the undergraduate and graduate levels. What is less known is his major role in public service where he served as chair of many important committees for the National Academy of Sciences, the National Institutes of Health, the National Institutes of Justice as well as various international programs. In all of these efforts, Professor Crow has left a lasting impact. PMID:22219505

  19. Kim Receives 2012 James R. Holton Junior Scientist Award: Response

    NASA Astrophysics Data System (ADS)

    Kim, Daehyun

    2013-08-01

    It is my great honor to be selected as a recipient of the James R. Holton Junior Scientist Award by AGU. I appreciate AGU and the award committee for the award. I first saw Professor Holton's name on his famous textbook when I was an undergraduate student. I remember his book made me think that atmospheric science was fun. I personally regard the prestigious award given to me as an encouraging message from the society, and I also feel that I have to pay back to the society in any way I can.

  20. SCUBA: A Camera for the James Clerk Maxwell Telescope

    NASA Astrophysics Data System (ADS)

    Gear, W. K.; Cunningham, C. R.

    We briefly describe the Submillimetre Common User Bolometer Array which has been built and is currently being tested at Edinburgh for the James Clerk Maxwell Telescope in Hawaii. This instrument will define the state-of-the-art in submillimetre continuum astronomical instrumentation. SCUBA has 2 arrays covering a field of two and a half arcminutes simultaneously in 2 submillimetre bands, plus 3 longer wavelength individual pixels for photometry. The detectors are germanium bolometers cooled to 0.1K with a dilution fridge and all pixels are background-limited.

  1. STS-89 M.S. James F. Reilly suits up

    NASA Technical Reports Server (NTRS)

    1998-01-01

    STS-89 Mission Specialist James Reilly, Ph.D., smiles as he completes the donning of his launch/entry suit in the Operations and Checkout (O&C) Building. He holds a doctorate in geosciences. He and six fellow crew members will shortly depart the O&C and head for Launch Pad 39A, where the Space Shuttle Endeavour will lift off during a launch window that opens at 9:43 p.m. EST, Jan. 22. STS-89 is the eighth of nine planned missions to dock the Space Shuttle with Russia's Mir space station.

  2. James Webb Space Telescope: The First Light Machine

    NASA Technical Reports Server (NTRS)

    Stahl, H. Philip

    2007-01-01

    Scheduled to begin its 10 year mission no sooner than 2013, the James Webb Space Telescope (JWST) will search for the first luminous objects of the Universe to help answer fundamental questions about how the Universe came to look like it does today. At 6.5 meters in diameter, JWST will be the world's largest space telescope. This talk reviews science objectives for JWST and how they drive the JWST architecture, e.g. aperture, wavelength range and operating temperature. Additionally, the talk provides an overview of the JWST primary mirror technology development and fabrication status.

  3. James Webb Space Telescope (JWST): The First Light Machine

    NASA Technical Reports Server (NTRS)

    Stahl, H. Philip

    2008-01-01

    The James Webb Space Telescope (JWST), expected to launch in 2011, will study the origin and evolution of luminous objects, galaxies, stars, planetary systems and the origins of life. It is optimized for near infrared wavelength operation of 0.6-28 micrometers and will have a 5 year mission life (with a 10 year goal). This presentation reviews JWST's science objectives, the JWST telescope and mirror requirements and how they support the JWST architecture. Additionally, an overview of the JWST primary mirror technology development effort is highlighted.

  4. An Overview of the James Webb Space Telescope (JWST) Project

    NASA Technical Reports Server (NTRS)

    Sabelhaus, Phillip A.

    2004-01-01

    The JWST project at the GSFC is responsible for the development, launch, operations and science data processing for the James Webb Space Telescope. The JWST project is currently in phase B with its launch scheduled for August 2011. The project is a partnership between NASA, ESA and CSA. The U.S. JWST team is now fully in place with the recent selection of Northrop Grumman Space Technology (NGST) as the prime contractor for the telescope and the Space Telescope Science Institute (STScI) as the mission operations and science data processing lead. This paper will provide an overview of the current JWST architecture and mission status including technology developments and risks.

  5. EMC Test Challenges for NASA's James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    McCloskey, John

    2016-01-01

    This presentation describes the electromagnetic compatibility (EMC) tests performed on the Integrated Science Instrument Module (ISIM), the science payload of the James Webb Space Telescope (JWST), at NASAs Goddard Space Flight Center (GSFC) in August 2015. By its very nature of being an integrated payload, it could be treated as neither a unit level test nor an integrated spacecraft observatory test. Non-standard test criteria are described along with non-standard test methods that had to be developed in order to evaluate them. Results are presented to demonstrate that all test criteria were met in less than the time allocated.

  6. James Cameron speaks out about ocean discovery and protection

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2013-06-01

    Ocean explorer and filmmaker James Cameron delivered his DEEPSEA CHALLENGER submersible vehicle to the Woods Hole Oceanographic Institution (WHOI) in Woods Hole, Mass., on 14 June, following a cross-country journey from California. He has donated the vehicle to WHOI as part of a new Center for Marine Robotics. Cameron, who will serve on the center's advisory board, used the submersible in March 2012 to dive to the deepest part of the ocean, the Challenger Deep section of the Mariana Trench in the Pacific Ocean (see Eos, 93(50), 523, doi:10.1029/2012EO500003).

  7. An Overview of the James Webb Space Telescope (JWST) Project

    NASA Technical Reports Server (NTRS)

    Sabelhaus, Phillip A.; Campbell, Doug; Clampin, Mark; Decker, John; Greenhouse, Matt; Johns, Alan; Menzel, Mike; Smith, Robert; Sullivan, Pam

    2005-01-01

    The JWST project at the GSFC is responsible for the development, launch, operations and science data processing for the James Webb Space Telescope. The JWST project is currently in phase B with its launch scheduled for August 2011. The project is a partnership between NASA, ESA and CSA. The U.S. JWST team is now fully in place with the selection of Northrop Grumman Space Technology (NGST) as the prime contractor for the telescope and the Space Telescope Science Institute (STScI) as the mission operations and science data processing lead. This paper will provide an overview of the current JWST architecture and mission status including technology developments and risks.

  8. James E. Watson, Jr.: Named to the Health Physics Society

    SciTech Connect

    Strom, Daniel J.; Stansbury, Paul S.

    2010-11-18

    At its 2010 Annual Meeting, the Health Physics Society named James E. Watson, Jr. to its Honor Roll of distinguished members. This citation summarizes Professor Jim Watson's life and professional career at the University of North Carolina at Chapel Hill, where he led the Radiological Hygiene program in the School of Public Health for nearly 3 decades. He was President of the Health Physics Society during the 1985-1986 term. He did pioneering work in radiation dose reconstruction for epidemiology as part of the U.S. Department of Energy Health and Mortality Studies.

  9. The James Webb Space Telescope and its Detector Systems

    NASA Technical Reports Server (NTRS)

    Rauscher, Bernard J.

    2009-01-01

    We describe the James Webb Space Telescope (JWST) mission, it's scientific goals, and how these drive detector systems technology. We describe the specific technologies that were developed (2.5 um and 5 um cutoff HgCdTe HAWAIIW2RG arrays for the 3 near-IR instruments, SIDECAR ASICs for the near-IR instruments, and Si:As arrays for the raid-IR instrument). We describe status in each of these areas with an emphasis on the performance of the flight detector systems themselves.

  10. Astronaut James Wetherbee briefed on use of Sky Genie

    NASA Technical Reports Server (NTRS)

    1994-01-01

    In preparation for his February 1995 spaceflight, Astronaut James D. Wetherbee, STS-63 mission commander, dons a training version of a partial pressure suit worn during Shuttle ascent and entry phases. He is accompanied by fellow crew members assigned to NASA's STS-63 mission. In the background are astronauts Bernard A. Harris, payload commander, along with Janice E. Voss and Russia's Vladimir Titov, both mission specialists. The training exercise was conducted in the Shuttle mockup and integration laboratory, where full-scale trainers provide the props for various training exercises at JSC.

  11. The octaheme SirA catalyses dissimilatory sulfite reduction in Shewanella oneidensis MR-1

    SciTech Connect

    Shirodkar, Sheetal; Reed, Samantha B.; Romine, Margaret F.; Saffarini, Daad

    2011-01-01

    Shewanella oneidensis MR-1 is a metal reducer that uses a large number of electron acceptors that include thiosulfate, polysulfide, and sulfite. The enzyme required for thiosulfate and polysulfide respiration has been recently identified, but the mechanisms of sulfite reduction remained unexplored. Analysis of MR-1 cultures grown anaerobically with sulfite suggested that the dissimilatory sulfite reductase catalyzes six-electron reduction of sulfite to sulfide. Reduction of sulfite required menaquinones and c cytochromes but appeared to be independent of the intermediate electron carrier CymA. Furthermore, the terminal sulfite reductase, SirA, was identified as an octaheme c cytochrome with an atypical heme binding site that represents a new class of sulfite reductases. The sirA locus was identified in the genomes of several sequenced Shewanella genomes, and its presence appears to be linked to the ability of these organisms to reduce sulfite under anaerobic conditions.

  12. Map self-validation: improved criteria to resolve the SIR or SAS phase ambiguity.

    PubMed

    Langs, D A; Blessing, R H; Guo, D

    2001-09-01

    A procedure was recently described that used the correlation coefficient (CC) agreement between the observed /F(h)/ and their associated unbiased 'omit map' extrapolated values /X(h)/ from an initial trial map as the basis for resolving the SIR or SAS phase ambiguity. It is noted here that a significant improvement in selectivity can be obtained if this agreement is expressed in terms of the complex-valued F(h) and X(h). A new scheme is outlined to exploit the weighted average of the two SIR or SAS phase choices. This procedure requires six FFTs per phase compared with three for the older method that randomly selected either of the two permitted phase choices from the Argand diagram as starting values. Trial calculations are encouraging for applications as low as 4 A resolution. PMID:11526342

  13. Solar Irradiance Reference Spectra (SIRS) for the 2008 Whole Heliosphere Interval (WHI)

    NASA Astrophysics Data System (ADS)

    Woods, Thomas N.; Chamberlin, Phillip C.; Harder, Jerald W.; Hock, Rachel A.; Snow, Martin; Eparvier, Francis G.; Fontenla, Juan; McClintock, William E.; Richard, Erik C.

    2009-01-01

    The IHY2007 Whole Heliosphere Interval (WHI) for solar Carrington Rotation 2068 (20 March to 16 April 2008) has been very successful in obtaining a wide variety of solar, heliospheric, and planetary observations during times of solar cycle minimum conditions. One of these efforts is the generation of solar irradiance reference spectra (SIRS) from 0.1 nm to 2400 nm using a combination of satellite and sounding rocket observations. These reference spectra include daily satellite observations from TIMED Solar Extreme ultraviolet Experiment (SEE) and Solar Radiation and Climate Experiment (SORCE) instruments. The extreme ultraviolet range is also improved with higher spectral resolution observations using the prototype SDO Extreme ultraviolet Variability Experiment (EVE) aboard a sounding rocket launched on 14 April 2008. The SIRS result is an important accomplishment in that it is the first data set to have simultaneous measurements over the full spectral coverage up to 2400 nm during solar cycle minimum conditions.

  14. Lava flow surface textures - SIR-B radar image texture, field observations, and terrain measurements

    NASA Technical Reports Server (NTRS)

    Gaddis, Lisa R.; Mouginis-Mark, Peter J.; Hayashi, Joan N.

    1990-01-01

    SIR-B images, field observations, and small-scale (cm) terrain measurements are used to study lave flow surface textures related to emplacement processes of a single Hawaiian lava flow. Although smooth pahoehoe textures are poorly characterized on the SIR-B data, rougher pahoehoe types and the a'a flow portion show image textures attributed to spatial variations in surface roughness. Field observations of six distinct lava flow textural units are described and used to interpret modes of emplacement. The radar smooth/rough boundary between pahoehoe and a'a occurs at a vertical relief of about 10 cm on this lava flow. While direct observation and measurement most readily yield information related to lava eruption and emplacement processes, analyses of remote sensing data such as those acquired by imaging radars and altimeters can provide a means of quantifying surface texture, identifying the size and distribution of flow components, and delineating textural unit boundaries.

  15. Segmenting and extracting terrain surface signatures from fully polarimetric multilook SIR-C data

    NASA Astrophysics Data System (ADS)

    Geaga, Jorge V.

    2016-05-01

    We report results from the segmenting and study of terrain surface signatures of fully polarimetric multilook L-band and C-band SIR-C data. Entropy/alpha/anisotropy decomposition features are available from single multilook pixel data. This eliminates the need to average data from several pixels. Entropy and alpha are utilized in the segmentation along with features we have developed primarily from the eigenanalysis of the Kennaugh matrices of multilook data. We have previously reported on our algorithm for segmenting fully polarimetric single look TerraSAR-X, multilook SIR-C and 7 band Landsat 5 data featuring the iterative application of a feedforward neural network with one hidden layer. A comparison of signatures from simultaneously recorded data at L and C bands is presented. The terrain surfaces surveyed include the ocean, lakes, lake ice, bare ground, desert salt flats, lava beds, vegetation, sand dunes, rough desert surfaces, agricultural and urban areas.

  16. Sir Peter Medawar: science, creativity and the popularization of Karl Popper

    PubMed Central

    Calver, Neil

    2013-01-01

    Sir Peter Medawar was respected by scientists and literati alike. It was perhaps not surprising, then, that he would choose to involve himself in the ‘two cultures’ debate of 1959 and beyond. The focus of his intervention was the philosophy of Sir Karl Popper. However, Medawar's Popper was not the guru of falsification familiar from philosophy textbooks. Medawar's distinctive interpretation of Popper treated him instead as the source of insights into the role of creativity and imagination in scientific inquiry. This paper traces the context for Medawar's adoption of Popperian philosophy, together with its application before the debate. It then examines, within the context of the debate itself, the way in which Medawar attempted to reconcile scientific inquiry with literary practice. Medawar became increasingly convinced that not only was induction epistemologically unsound, but it was also damaging to the public role of the scientist. His construction of Popperianism would, he envisaged, provide a worthy alternative for scientists’ self-image.

  17. The SIR-C ground data system: Digital processor, data products, information flow

    NASA Technical Reports Server (NTRS)

    Curlander, John C.

    1986-01-01

    The SIR-C (Shuttle Imaging Radar) instrument will collect both C-Band and L-Band data with each frequency band consisting of direct (HH or VV) and cross-polarized (HV or VH) data. Considering all possible combinations as many as eight different data channels will be available for any given target area. This data will be digitized and formatted on-board for direct downlink via the Tracking and Data Relay Satellite System (TDRSS), or it will be buffered through on-board high density digital recorders for storage or transmission when TDRSS is available. The data is received by the TDRSS ground station at White Sands and is nominally relayed via DOMSAT to the high data rate recording facility at GSFC. The tapes are then shipped to JPL for processing into imagery and eventual distribution to the SIR-C investigators.

  18. Analysis of data acquired by Shuttle Imaging Radar SIR-A and Landsat Thematic Mapper over Baldwin County, Alabama

    NASA Technical Reports Server (NTRS)

    Wu, S.-T.

    1985-01-01

    Seasonally compatible data collected by SIR-A and by Landsat 4 TM over the lower coastal plain in Alabama were coregistered, forming a SIR-A/TM multichannel data set with 30 m x 30 m pixel size. Spectral signature plots and histogram analysis of the data were used to observe data characteristics. Radar returns from pine forest classes correlated highly with the tree ages, suggesting the potential utility of microwave remote sensing for forest biomass estimation. As compared with the TM-only data set, the use of SIR-A/TM data set improved classification accuracy of the seven land cover types studied. In addition, the SIR-A/TM classified data support previous finding by Engheta and Elachi (1982) that microwave data appear to be correlated with differing bottomland hardwood forest vegetation as associated with varying water regimens (i.e., wet versus dry).

  19. The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae.

    PubMed

    Hass, Evan P; Zappulla, David C

    2015-01-01

    In Saccharomyces cerevisiae and in humans, the telomerase RNA subunit is bound by Ku, a ring-shaped protein heterodimer best known for its function in DNA repair. Ku binding to yeast telomerase RNA promotes telomere lengthening and telomerase recruitment to telomeres, but how this is achieved remains unknown. Using telomere-length analysis and chromatin immunoprecipitation, we show that Sir4 - a previously identified Ku-binding protein that is a component of telomeric silent chromatin - is required for Ku-mediated telomere lengthening and telomerase recruitment. We also find that specifically tethering Sir4 directly to Ku-binding-defective telomerase RNA restores otherwise-shortened telomeres to wild-type length. These findings suggest that Sir4 is the telomere-bound target of Ku-mediated telomerase recruitment and provide one mechanism for how the Sir4-competing Rif1 and Rif2 proteins negatively regulate telomere length in yeast. PMID:26218225

  20. The design and development of two-failure tolerant mechanisms for the Spaceborne Imaging Radar (SIR-B) antenna

    NASA Technical Reports Server (NTRS)

    Presas, S. J.

    1984-01-01

    The performance requirements, design constraints, and design qualification status of the mechanisms necessary to restrain, deploy, and stow the Spaceborne Imaging Radar (SIR) B antenna experiment on the Shuttle Orbiters are described.

  1. SYNTHESIS OF HAPTENS AND POTENTIAL RADIOLIGANDS AND DEVELOPMENT OF ANTIBODIES TO INSECT GROWTH REGULATORS DIFLUBENZURON AND BAY SIR 8514

    EPA Science Inventory

    A variety of synthetic approaches were undertaken, leading to potential haptens and radioligands for the benzoylphenylurea insect growth regulators diflubenzuron and BAY SIR 8514. One successful approach involved derivatization of the aniline nitrogen by ethyl 4-bromobutyrate fol...

  2. SIR phasing by combination of SOLVE/RESOLVE and dual-space fragment extension involving OASIS

    NASA Astrophysics Data System (ADS)

    He, Yao; Gu, Yuan-Xin; Lin, Zheng-Jiong; Zheng, Chao-De; Fan, Hai-Fu

    2007-10-01

    A new phasing procedure has been proposed for dealing with single isomorphous replacement (SIR) x-ray diffraction data. The procedure combines SOLVE/RESOLVE with the dual-space fragment extension involving OASIS. Two sets of SIR data at 0.28 nm resolution taken from the protein (R)-phycoerythrin (PDB code: 1LIA) were used in the test. For one of the two SIR data sets, a default run of SOLVE/RESOLVE based on the heavy-atom substructure found by SHLEXD led automatically to an interpretable electron density map. OASIS could not effectively improve the result. For the other set of SIR data, SOLVE/RESOLVE resulted in a fragmented model consisting of 454 of the total 668 residues, in which only 29 residues were docked into the sequence. Based on this model, 7 iteration cycles of OASIS-DM-RESOLVE (build only) yielded automatically a model of 547 residues with 133 residues docked into the sequence. The overall-averaged phase error decreased considerably and the quality of electron density map was improved significantly. Two more cycles of iterative OASIS-DM-RESOLVE were carried out, in which the output phases and figures of merit from DM were merged with that from the original run of SOLVE/RESOLVE before they were passed onto RESOLVE (build only). This led automatically to a model containing 452 residues with 173 docked into the sequence. The resultant electron density map is manually traceable. It is concluded that when results of SOLVE/RESOLVE are not sufficiently satisfactory, the combination of SOLVE/RESOLVE and OASIS-DM-RESOLVE (build only) may significantly improve them.

  3. Stability of traveling waves of a diffusive susceptible-infective-removed (SIR) epidemic model

    NASA Astrophysics Data System (ADS)

    Li, Yan; Li, Wan-Tong; Yang, Yun-Rui

    2016-04-01

    This paper is concerned with the stability and uniqueness of traveling waves of a delayed diffusive susceptible-infective-removed (SIR) epidemic model. We first prove the exponential stability of traveling waves by using the weighted energy method, where the traveling waves are allowed to be non-monotone. Then we establish the exact asymptotic behavior of traveling waves at -∞ by using Ikehara's theorem. Finally, the uniqueness of traveling waves is proved by the stability result of traveling waves.

  4. Everything to gain: Sir Hugh Cairns' treatment of central nervous system infection at Oxford and abroad.

    PubMed

    Chalif, Joshua I; Gillies, Martin J; Magdum, Shailendra A; Aziz, Tipu Z; Pereira, Erlick A C

    2013-02-01

    Antibiotics have revolutionized survival from central nervous system (CNS) infections. Sixty years after the death of Sir Hugh Cairns, we present archive material of historical interest from the Radcliffe Infirmary in Oxford from the time of his first trials of penicillin for CNS infection. We discuss Cairns' important wartime and subsequent contributions to antibiosis in CNS infection and include drawings by Audrey Arnott illustrating the surgical techniques used to treat abscesses at the time. PMID:23149954

  5. The threshold of a stochastic delayed SIR epidemic model with temporary immunity

    NASA Astrophysics Data System (ADS)

    Liu, Qun; Chen, Qingmei; Jiang, Daqing

    2016-05-01

    This paper is concerned with the asymptotic properties of a stochastic delayed SIR epidemic model with temporary immunity. Sufficient conditions for extinction and persistence in the mean of the epidemic are established. The threshold between persistence in the mean and extinction of the epidemic is obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number R0 of the deterministic system.

  6. Epidemics of Sirs Model with Nonuniform Transmission on Scale-Free Networks

    NASA Astrophysics Data System (ADS)

    Xia, C. Y.; Sun, S. W.; Liu, Z. X.; Chen, Z. Q.; Yuan, Z. Z.

    We investigate the effect of nonuniform transmission on the critical threshold of susceptible-infected-recovered-susceptible (SIRS) epidemic model on scale-free networks. Based on the mean-field theory, it is observed that the epidemic threshold is not only correlated with the topology of underlying networks, but also with the disease transmission mechanism (e.g., nonuniform transmission). The current findings will significantly help us to further understand the real epidemics taking place on social and technological networks.

  7. Carbon-14 dating of an iron bloom associated with the voyages of Sir Martin Frobisher

    SciTech Connect

    Sayre, E.V.; Harbottle, G.; Stoenner, R.W. Washburn, W.; Olin, J.S.; Fitzhugh, W.

    1982-01-01

    This paper recounts the history of the iron bloom associated with the English Elizabethan explorer Sir Martin Frobisher who made 3 voyages to the North American mainland in the 1570's. Specifically the paper deals with the use of proportional counters in carbon-14 dating of the Frobisher iron bloom which is located at the Smithsonian Institution. The procedures for preparing the samples for counting are described. (KRM)

  8. Milestones in plant sulfur research on sulfur-induced-resistance (SIR) in Europe.

    PubMed

    Bloem, Elke; Haneklaus, Silvia; Schnug, Ewald

    2014-01-01

    Until the 1970's of the last century sulfur (S) was mainly regarded as a pollutant being the main contributor of acid rain, causing forest dieback in central Europe. When Clean Air Acts came into force at the start of the 1980's SO2 contaminations in the air were consequently reduced within the next years. S changed from an unwanted pollutant into a lacking plant nutrient in agriculture since agricultural fields were no longer "fertilized" indirectly by industrial pollution. S deficiency was first noticed in Brassica crops that display an especially high S demand because of its content of S-containing secondary metabolites, the glucosinolates. In Scotland, where S depositions decreased even faster than in continental Europe, an increasing disease incidence with Pyrenopeziza brassicae was observed in oilseed rape in the beginning 1990's and the concept of sulfur-induced-resistance (SIR) was developed after a relationship between the S status and the disease incidence was uncovered. Since then a lot of research was carried out to unravel the background of SIR in the metabolism of agricultural crops and to identify metabolites, enzymes and reactions, which are potentially activated by the S metabolism to combat fungal pathogens. The S status of the crop is affecting many different plant features such as color and scent of flowers, pigments in leaves, metabolite concentrations and the release of gaseous S compounds which are directly influencing the desirability of a crop for a variety of different organisms from microorganisms, over insects and slugs to the point of grazing animals. The present paper is an attempt to sum up the knowledge about the effect of the S nutritional status of agricultural crops on parameters that are directly related to their health status and by this to SIR. Milestones in SIR research are compiled, open questions are addressed and future projections were developed. PMID:25642233

  9. Milestones in plant sulfur research on sulfur-induced-resistance (SIR) in Europe

    PubMed Central

    Bloem, Elke; Haneklaus, Silvia; Schnug, Ewald

    2015-01-01

    Until the 1970's of the last century sulfur (S) was mainly regarded as a pollutant being the main contributor of acid rain, causing forest dieback in central Europe. When Clean Air Acts came into force at the start of the 1980's SO2 contaminations in the air were consequently reduced within the next years. S changed from an unwanted pollutant into a lacking plant nutrient in agriculture since agricultural fields were no longer “fertilized” indirectly by industrial pollution. S deficiency was first noticed in Brassica crops that display an especially high S demand because of its content of S-containing secondary metabolites, the glucosinolates. In Scotland, where S depositions decreased even faster than in continental Europe, an increasing disease incidence with Pyrenopeziza brassicae was observed in oilseed rape in the beginning 1990's and the concept of sulfur-induced-resistance (SIR) was developed after a relationship between the S status and the disease incidence was uncovered. Since then a lot of research was carried out to unravel the background of SIR in the metabolism of agricultural crops and to identify metabolites, enzymes and reactions, which are potentially activated by the S metabolism to combat fungal pathogens. The S status of the crop is affecting many different plant features such as color and scent of flowers, pigments in leaves, metabolite concentrations and the release of gaseous S compounds which are directly influencing the desirability of a crop for a variety of different organisms from microorganisms, over insects and slugs to the point of grazing animals. The present paper is an attempt to sum up the knowledge about the effect of the S nutritional status of agricultural crops on parameters that are directly related to their health status and by this to SIR. Milestones in SIR research are compiled, open questions are addressed and future projections were developed. PMID:25642233

  10. Spectral measurements in support of SIR-B using the Surface Contour Radar. [for South Pacific

    NASA Technical Reports Server (NTRS)

    Walsh, E. J.; Hancock, D. W., III; Hines, D. E.; Swift, R. N.; Scott, J. F.

    1985-01-01

    The use of the Surface Contour Radar (SCR) from an aircraft to obtain spectral information on the seas off the tip of South America, in support of the SIR-B experiment in October 1984, is reported. The SCR is a computer-controlled 36-GHz radar that measures sea surface directional wave spectra and produces a real-time topographical map of the surface below the aircraft. Ground tracks and polar plots of the data obtained are illustrated.

  11. Sir William Wilde and provision for the blind in nineteenth-century Ireland.

    PubMed

    Mullaney, S

    2016-05-01

    As Assistant Commissioner for the Census of Ireland Sir William Wilde worked as an early epidemiologist, providing information regarding the deaf-and-dumb and the blind in mid-nineteenth-century Ireland. As a social agitator he focussed the attention of the authorities to the plight of the blind and their inability to earn a living and support themselves. This paper highlights his contribution to the provision for the blind in Ireland. PMID:27083458

  12. Analysis of Melt Flows observed by SIR-2 and LROC NAC: Stevinus A

    NASA Astrophysics Data System (ADS)

    Mall, U.; Wöhler, C.; Grumpe, A.; Bugiolacchi, R.

    2013-09-01

    Impact melt structures occur in and around young craters from 200 m to hundreds of kilometers in diameter. Impact events lead to melting and vaporization processes. Through the combination of high-resolution LROC NAC images and measurements made by the SIR-2 point spectrometer carried by Chandrayaan-1, compositional aspects can be investigated in a manner hitherto impossible. We will present and discuss as a specific example first results for the small lunar crater Stevinus A.

  13. Automated matching of pairs of SIR-B images for elevation mapping

    NASA Technical Reports Server (NTRS)

    Ramapriyan, H. K.; Strong, J. P.; Murray, C. W., Jr.; Hung, Y.

    1986-01-01

    During the SIR-B mission in October 1984, a significant number of overlapping synthetic aperture radar (SAR) images of various ground areas was collected. This has offered the first opportunity to perform stereo analyses on images from space that cover large ground areas to determine elevation information. This paper presents the preliminary results of an investigation to obtain elevation data from stereo pairs of SIR-B images. First, the accuracy with which elevation information can be derived from SIR-B image pairs is evaluated theoretically. It is shown that elevation accuracy is a function of the slant range resolution, the incidence angles with which the stereo pair is obtained, the accuracies in spacecraft state estimation, and determination of corresponding pixels in the stereo pair. Next, a hierarchical method is developed to match the corresponding pixels. This method involves iterative removal of local distortions and correlations of pairs of local neighborhoods in the two images. Since it is necessary to perform the matching at every pixel in the image, it is very computationally intensive. Therefore, it has been implemented on the Massively Parallel Processor (MPP) at the Goddard Space Flight Center (GSFC). The MPP's speed permits two iterations of this technique to operate on a pair of 512 x 512 images within 7 s. Results of applying this algorithm of SIR-B images of Mount Shasta, CA, are shown. The matching algorithm performs well in regions of the image with significant features. An approximate elevation image derived from the matching process corresponds to published topographic map data, except for certain obvious discontinuities.

  14. Recombinant NAD-dependent SIR-2 Protein of Leishmania donovani: Immunobiochemical Characterization as a Potential Vaccine against Visceral Leishmaniasis

    PubMed Central

    Baharia, Rajendra K; Tandon, Rati; Sharma, Tanuj; Suthar, Manish K; Das, Sanchita; Siddiqi, Mohammad Imran; Saxena, Jitendra Kumar; Sunder, Shyam; Dube, Anuradha

    2015-01-01

    Background The development of a vaccine conferring long-lasting immunity remains a challenge against visceral leishmaniasis (VL). Immunoproteomic characterization of Leishmania donovani proteins led to the identification of a novel protein NAD+-dependent Silent Information regulatory-2 (SIR2 family or sirtuin) protein (LdSir2RP) as one of the potent immunostimulatory proteins. Proteins of the SIR2 family are characterized by a conserved catalytic domain that exerts unique NAD-dependent deacetylase activity. In the present study, an immunobiochemical characterization of LdSir2RP and further evaluation of its immunogenicity and prophylactic potential was done to assess for its possible involvement as a vaccine candidate against leishmaniasis. Methodology/Principal Findings LdSir2RP was successfully cloned, expressed and purified. The gene was present as a monomeric protein of ~45 kDa and further established by the crosslinking experiment. rLdSir2RP shown cytosolic localization in L. donovani and demonstrating NAD+-dependent deacetylase activity. Bioinformatic analysis also confirmed that LdSir2RP protein has NAD binding domain. The rLdSir2RP was further assessed for its cellular response by lymphoproliferative assay and cytokine ELISA in cured Leishmania patients and hamsters (Mesocricetus auratus) in comparison to soluble Leishmania antigen and it was observed to stimulate the production of IFN-γ, IL-12 and TNF-α significantly but not the IL-4 and IL-10. The naïve hamsters when vaccinated with rLdSir2RP alongwith BCG resisted the L. donovani challenge to the tune of ~75% and generated strong IL-12 and IFN-γ mediated Th1 type immune response thereof. The efficacy was further supported by remarkable increase in IgG2 antibody level which is indicative of Th1 type of protective response. Further, with a possible implication in vaccine design against VL, identification of potential T-cell epitopes of rLdSir2RP was done using computational approach. Conclusion

  15. James Parkinson (1755-1824): a pioneer of child care.

    PubMed

    Pearn, J; Gardner-Thorpe, C

    2001-02-01

    James Parkinson (1755-1824) of Parkinson's disease, is well recognized as a pioneer of clinical neurology; and is even more famous as a founder of modern palaeontology. We have reviewed from primary sources his extensive contributions to clinical child care and his pioneering advocacy for child welfare, protection and safety. His writings, outreach and advocacy for children's health characterizes him as one whose influence was an important springboard from which evolved the modern specialty of paediatrics. Parkinson was one of the first to write on child-rearing practices and in this context antedated Benjamin Spock by 150 years. Parkinson was a pioneer of child safety and the prevention of childhood trauma. He wrote of the resuscitation of near-drowned children and of first aid for injured children. This critical analysis reviews his pioneering description of child abuse and the development of post-abuse hydrocephalus. He wrote the datum description (in English) of the pathophysiology and pathology of appendicitis in children, of fatal rabies in children and highlighted the risk of death even when the biting dog was not clinically rabid. His advocacy for social reform for children's welfare was courageous and pioneering. James Parkinson, hitherto unacknowledged, was a significant founder of the evolving discipline of paediatrics and child health. PMID:11168861

  16. DNA discoverer James Watson now dreams of curing genetic diseases

    SciTech Connect

    Breo, D.L.

    1989-12-15

    The best-selling The Double Helix, published 20 years ago, describes the events that had led to the discovery by James Watson and Francis Crick in 1953 of the structure of deoxyribonucleic acid (DNA), the building block of genes and heredity. At the time, the 25-year-old Watson was widely perceived as arrogant, brash, gawky, and intense. Subsequent events did little to change that impression. Today, at age 61, James Dewey Watson is still an angry young man. As director since 1968 of the Cold Spring Harbor Laboratory on Long Island, NY, and as director since 1988 of the National Center for Human Genome Research at the National Institutes of Health (NIH), he is coordinating the attempt to decipher biology's deepest secrets: the mapping, sequencing, and defining of the estimated 50,000 to 100,000 human genes arranged over the 23 pairs of chromosomes. The results, expected by early next century, may reveal the chemical script of life and help solve the riddles of inherited genetic diseases and certain cancers.

  17. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    SciTech Connect

    Samat, N. A.; Ma'arof, S. H. Mohd Imam

    2014-12-04

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

  18. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    NASA Astrophysics Data System (ADS)

    Samat, N. A.; Ma'arof, S. H. Mohd Imam

    2014-12-01

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

  19. Solar Irradiance Reference Spectra (SIRS) for IHY2007 Whole Heliosphere Interval (WHI)

    NASA Astrophysics Data System (ADS)

    Woods, T.; Chamberlin, P.; Snow, M.; Harder, J.

    2008-12-01

    The IHY2007 Whole Heliosphere Interval (WHI) for solar Carrington Rotation 2068 (20 March to 16 April 2008) has been very successful in obtaining a wide variety of solar, heliospheric, and planetary observations during times of solar cycle minimum conditions. One of these efforts is the generation of solar irradiance reference spectra (SIRS) from 0.1 nm to 2400 nm using a combination of satellite and sounding rocket observations. These reference spectra include daily satellite observations from TIMED Solar EUV Experiment (SEE) from 0.1 nm to 116 nm and from Solar Radiation and Climate Experiment (SORCE) instruments from 116 nm to 2400 nm. The EUV range is also improved with higher spectral resolution observations from 6 nm to 105 nm using the prototype SDO EUV Variability Experiment (EVE) aboard a sounding rocket launched on 14 April 2008. The SIRS result is an important accomplishment in that it is the first time in having simultaneous measurements over the full spectral coverage up to 2400 nm and during solar cycle minimum conditions. The SIRS data from 0.1 nm to 2400 nm and in 0.1-nm intervals (on 0.05 nm centers) are available from http://ihy2007.org/WHI/.

  20. The Extreme Ultraviolet Contributions to the Solar Irradiance Reference Spectrum (SIRS)

    NASA Astrophysics Data System (ADS)

    Chamberlin, P. C.; Woods, T. N.; Harder, J. W.; Hock, R. A.; Snow, M.

    2008-12-01

    The Whole Heliosphere Interval (WHI) was a coordinated effort with inputs from over 50 models and observatories, both satellite and ground based, to characterize the Sun and heliosphere during solar minimum conditions. The time period selected for this quiet Sun WHI campaign was April 10-16, 2008. One of the goals of the solar minimum WHI was to produce a definitive Solar Irradiance Reference Spectrum (SIRS) for quiet Sun conditions ranging in wavelength from 0.1 nm up to 2400 nm. During this WHI campaign on April 14, 2008, a sounding rocket was launched from White Sands Missile Range that observed the solar spectral irradiance in these solar minimum conditions in the extreme ultraviolet (EUV) wavelength range from 0.1-106 nm as well as the bright hydrogen Lyman alpha emission at 121.6 nm. The rocket observations from 6.0-106.0 nm and at 0.1 nm spectral resolution are the EUV input for the SIRS. These rocket EUV measurements are discussed following a brief introduction to the entire SIRS spectrum developed for the WHI campaign.

  1. Simulation of emotional contagion using modified SIR model: A cellular automaton approach

    NASA Astrophysics Data System (ADS)

    Fu, Libi; Song, Weiguo; Lv, Wei; Lo, Siuming

    2014-07-01

    Emotion plays an important role in the decision-making of individuals in some emergency situations. The contagion of emotion may induce either normal or abnormal consolidated crowd behavior. This paper aims to simulate the dynamics of emotional contagion among crowds by modifying the epidemiological SIR model to a cellular automaton approach. This new cellular automaton model, entitled the “CA-SIRS model”, captures the dynamic process ‘susceptible-infected-recovered-susceptible', which is based on SIRS contagion in epidemiological theory. Moreover, in this new model, the process is integrated with individual movement. The simulation results of this model show that multiple waves and dynamical stability around a mean value will appear during emotion spreading. It was found that the proportion of initial infected individuals had little influence on the final stable proportion of infected population in a given system, and that infection frequency increased with an increase in the average crowd density. Our results further suggest that individual movement accelerates the spread speed of emotion and increases the stable proportion of infected population. Furthermore, decreasing the duration of an infection and the probability of reinfection can markedly reduce the number of infected individuals. It is hoped that this study will be helpful in crowd management and evacuation organization.

  2. The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation.

    PubMed Central

    Aström, Stefan U; Cline, Thomas W; Rine, Jasper

    2003-01-01

    Five Drosophila melanogaster genes belong to the highly conserved sir2 family, which encodes NAD(+)-dependent protein deacetylases. Of these five, dsir2(+) (CG5216) is most similar to the Saccharomyces cerevisiae SIR2 gene, which has profound effects on chromatin structure and life span. Four independent Drosophila strains were found with P-element insertions near the dsir2 transcriptional start site as well as extraneous linked recessive lethal mutations. Imprecise excision of one of these P elements (PlacW07223) from a chromosome freed of extraneous lethal mutations produced dsir2(17), a null intragenic deletion allele that generates no DSIR2 protein. Contrary to expectations from the report by Rosenberg and Parkhurst on their P-mobilization allele dSir2(ex10), homozygosity for dsir2(17) had no apparent deleterious effects on viability, developmental rate, or sex ratio, and it fully complemented sir2(ex10). Moreover, through a genetic test, we ruled out the reported effect of dSir2(ex10) on Sex-lethal expression. We did observe a modest, strictly recessive suppression of white(m4) position-effect variegation and a shortening of life span in dsir2 homozygous mutants, suggesting that dsir2 has some functions in common with yeast SIR2. PMID:12663533

  3. Lonely Courage, Commemorative Confrontation, and Communal Therapy: William James Remembers the Massachusetts 54th

    ERIC Educational Resources Information Center

    Stob, Paul

    2012-01-01

    On May 31, 1897, William James, one of America's most influential philosophers and psychologists, delivered the first civic oration of his career. The principal orator at the dedication of the Robert Gould Shaw memorial in Boston, James did what commemorative speakers are not supposed to do. He chose to be confrontational and divisive in a…

  4. James Burrill Angell's China Mission, 1880-1881: The Forging of an Internationalist University Presidency.

    ERIC Educational Resources Information Center

    Campbell, Malcolm B.

    The monograph reviews the life and development of James Burrill Angell, president of the University of Michigan (1871-1909), with special emphasis on his internationalist perspective and its implications for higher education. An examination is made of James Burrill Angell's sojourns into the world of international diplomacy and politics during the…

  5. Landscapes of Removal and Resistance: Edwin James's Nineteenth-Century Cross-Cultural Collaborations

    ERIC Educational Resources Information Center

    Lyndgaard, Kyhl

    2010-01-01

    The life of Edwin James (1797-1861) is bookended by the Lewis and Clark expedition (1803-6) and the Civil War (1861-65). James's work engaged key national concerns of western exploration, natural history, Native American relocation, and slavery. His principled stands for preservation of lands and animals in the Trans-Mississippi West and his…

  6. On the Relation of Morality and Religion: Two Lessons from James's "Varieties of Religious Experience"

    ERIC Educational Resources Information Center

    Keljo, Kurt; Christenson, Tom

    2003-01-01

    Drawing chiefly on the reflections of William James in his classic work, "The Varieties of Religious Experience," this article explores the dynamics of a mutually enriching relationship between religion and morality, whereby the two domains animate and inform each other. James's work is explored to suggest the outlines of such a relationship,…

  7. 78 FR 11094 - Drawbridge Operation Regulation; James River, Between Isle of Wight and Newport News, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... and Newport News, VA AGENCY: Coast Guard, DHS. ACTION: Notice of deviation from drawbridge regulation... News, VA. This deviation is necessary to facilitate generator replacement on the James River Draw... operating schedule, the James River Bridge, mile 5.0, between Isle of Isle and Newport News, VA opens...

  8. The Varieties of Emotional Experience: A Meditation on James-Lange Theory.

    ERIC Educational Resources Information Center

    Lang, Peter J.

    1994-01-01

    This article traces the origin of the James-Lange theory of emotion, considers differences in their thinking, and assesses early criticisms and debate. Research on physiological patterns in emotion is reviewed. New paths for emotion research are outlined and homage is paid to the inspiration of William James. (SLD)

  9. The Psychology and Philosophy of William James: An Interdisciplinary Teaching Project.

    ERIC Educational Resources Information Center

    Viney, Wayne; Crosby, Donald A.

    1991-01-01

    Discusses an interdisciplinary course on the psychology and philosophy of William James. Describes course organization and goals. Explains that the course includes sections on James' life and personal characteristics, his psychological and philosophical works, and specific psychological and philosophical topics that he addressed. Assesses…

  10. Moral Development as the Personal Education of Feeling and Reason: From James to Piaget

    ERIC Educational Resources Information Center

    Ferrari, Michel; Okamoto, Carol M.

    2003-01-01

    This article traces the connection between William James's writings in "The Varieties of Religious Experience" and Jean Piaget's work on moral development through Piaget's early work on religious experience. James characterises religious experience as unlocking deep personal power that can sustain a "strenuous mood". These ideas impacted the early…

  11. 75 FR 11575 - James A. Fitzpatrick Nuclear Power Plant Environmental Assessment and Finding of No Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... COMMISSION James A. Fitzpatrick Nuclear Power Plant Environmental Assessment and Finding of No Significant... Program for Nuclear Power Facilities Operating Prior to January 1, 1979,'' issued to Entergy Nuclear Operations, Inc. (the licensee), for the operation of the James A. FitzPatrick Nuclear Power Plant...

  12. Introspecting in the Spirit of William James: Comment on Fox, Ericsson, and Best (2011)

    ERIC Educational Resources Information Center

    Schooler, Jonathan W.

    2011-01-01

    Fox, Ericsson, and Best's (2011) thoughtful justification of the use of think-aloud protocols for revealing the stream of consciousness comes on the centennial of the death of William James, history's greatest practitioner and advocate of introspection. This confluence naturally invites speculation about how James might have responded to the…

  13. The King James Bible and the Politics of Religious Education: Secular State and Sacred Scripture

    ERIC Educational Resources Information Center

    Gearon, Liam

    2013-01-01

    This article provides an outline historical-educational analysis of the King James Bible from its 1611 publication through to its four-hundredth anniversary commemoration in 2011. With particular focus on England, the article traces the educational impact of the King James Bible and charts, in the country of its origin, its progressive decline in…

  14. Physiology as the antechamber to metaphysics: the young William James's hope for a philosophical psychology.

    PubMed

    Croce, P J

    1999-11-01

    In the 5 years before 1878, when his career in psychology was becoming established, William James wrote a series of notes and reviews assessing the work of many of the pioneers in the new field. Adopting a public and confident voice, even while he was privately still uncertain and searching, James criticized the dogmatism of positivist and idealist claims to the study of the human brain and mind. In his short writings of 1873-1877, James started to formulate his own middle path. His first steps on that path show that he did not reject either scientific or philosophic inquiry; instead, he viewed scientific knowledge as a way to understand philosophical questions more deeply. Saving his sharpest critiques for positivism, James endorsed scientific investigation without materialist assmptions. While his career in psychology was still only a hope, James treated science as a means toward humanist insight. PMID:11624576

  15. STS-88 Mission Specialist James Newman suits up before launch

    NASA Technical Reports Server (NTRS)

    1998-01-01

    In the Operations and Checkout Building, STS-88 Mission Specialist James H. Newman takes part in a complete suit check before launch. Newman holds a toy dog, 'Pluto,' representing the crew nickname Dog Crew 3 and Newman's nickname, Pluto. Mission STS-88 is expected to launch at 3:56 a.m. EST with the six-member crew aboard Space Shuttle Endeavour on Dec. 3. Endeavour carries the Unity connecting module, which the crew will be mating with the Russian-built Zarya control module already in orbit. In addition to Unity, two small replacement electronics boxes are on board for possible repairs to Zarya batteries. The mission is expected to last 11 days, 19 hours and 49 minutes, landing at 10:17 p.m. EST on Dec. 14.

  16. Astronaut James S. Voss Performs Tasks in the Destiny Laboratory

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Astronaut James S. Voss, Expedition Two flight engineer, works with a series of cables on the EXPRESS Rack in the United State's Destiny laboratory on the International Space Station (ISS). The EXPRESS Rack is a standardized payload rack system that transports, stores, and supports experiments aboard the ISS. EXPRESS stands for EXpedite the PRocessing of Experiments to the Space Station, reflecting the fact that this system was developed specifically to maximize the Station's research capabilities. The EXPRESS Rack system supports science payloads in several disciplines, including biology, chemistry, physics, ecology, and medicine. With the EXPRESS Rack, getting experiments to space has never been easier or more affordable. With its standardized hardware interfaces and streamlined approach, the EXPRESS Rack enables quick, simple integration of multiple payloads aboard the ISS. The system is comprised of elements that remain on the ISS, as well as elements that travel back and forth between the ISS and Earth via the Space Shuttle.

  17. James Webb Space Telescope Optical Telescope Element Mirror Coatings

    NASA Technical Reports Server (NTRS)

    Keski-Kuha, Ritva A.; Bowers, Charles W.; Quijada, Manuel A.; Heaney, James B.; Gallagher, Benjamin; McKay, Andrew; Stevenson, Ian

    2012-01-01

    James Webb Space Telescope (JWST) Optical Telescope Element (OTE) mirror coating program has been completed. The science goals of the JWST mission require a uniform, low stress, durable optical coating with high reflectivity over the JWST spectral region. The coating has to be environmentally stable, radiation resistant and compatible with the cryogenic operating environment. The large size, 1.52 m point to point, light weight, beryllium primary mirror (PM) segments and flawless coating process during the flight mirror coating program that consisted coating of 21 flight mirrors were among many technical challenges. This paper provides an overview of the JWST telescope mirror coating program. The paper summarizes the coating development program and performance of the flight mirrors.

  18. The case of James A. Garfield: a historical perspective.

    PubMed

    Weiner, Bradley K

    2003-05-15

    In 1881, President James A. Garfield was shot in the back and died 79 days later. During this time, many controversies arose that had repercussions for years to come. Who was to manage the President's care? A prominent local physician took on the case, but after Garfield's death, he was highly criticized for inappropriate care and for excluding more highly qualified surgeons. Where was the bullet? Multiple opinions were given including that of Alexander Graham Bell. The correct suggestion turned out to be that of a young, unknown assistant demonstrator of anatomy. What was the proper treatment? Local wound care, removal of the bullet, and laparotomy all were considered. Many have felt that the choice of treatment may have proved to be worse than the injury itself. What did the autopsy show? Even this was controversial, with different observers claiming different results. This historical perspective reviews the case as well the controversies that surrounded it. PMID:12768155

  19. The James Webb Space Telescope: Science and Mission Status

    NASA Technical Reports Server (NTRS)

    Sonneborn, George

    2011-01-01

    The James Webb Space Telescope (JWST) is a large aperture, cryogenic, infrared-optimized space observatory under construction by NASA for launch later this decade. The European and Canadian Space Agencies are mission partners. JWST will find and study the first galaxies that formed in the early universe and peer through dusty clouds to see star and planet formation at high spatial resolution. The breakthrough capabilities of JWST will enable new studies of star formation and evolution in the Milky Way, including the Galactic Center, nearby galaxies, and the early universe. JWST will have a segmented primary mirror, approximately 6.5 meters in diameter, and will be diffraction-limited at 2 microns. The JWST observatory will be placed in a L2 orbit by an Ariane 5 launch vehicle provided by ESA. The observatory is designed for a 5- year prime science mission, with consumables for 10 years of science operations.

  20. Status Update on the James Webb Space Telescope Project

    NASA Technical Reports Server (NTRS)

    Rigby, Jane R.

    2012-01-01

    The James Webb Space Telescope (JWST) is a large (6.6 m), cold <50 K), infrared (IR)-optimized space observatory that will be launched in approx.2018. The observatory will have four instruments covering 0.6 to 28 micron, including a multi-object spectrograph, two integral field units, and grisms optimized for exoplanets. I will review JWST's key science themes, as well as exciting new ideas from the recent JWST Frontiers Workshop. I will summarize the technical progress and mission status. Recent highlights: All mirrors have been fabricated, polished, and gold-coated; the mirror is expected to be diffraction-limited down to a wavelength of 2 microns. The MIRI instrument just completed its cryogenic testing. STScI has released exposure time calculators and sensitivity charts to enable scientists to start thinking about how to use JWST for their science.

  1. Status Update on the James Webb Space Telescope Project

    NASA Technical Reports Server (NTRS)

    Rigby, Jane R.

    2011-01-01

    The James Webb Space Telescope (JWST) is a large (6.6 m), cold (<50 K), infrared (IR)-optimized space observatory that will be launched in approx.2018. The observatory will have four instruments covering 0.6 to 28 micron, including a multi-object spectrograph, two integral fie ld units, and grisms optimized for exoplanets. I will review JWST's k ey science themes, as well as exciting new ideas from the recent JWST Frontiers Workshop. I will summarize the technical progress and miss ion status. Recent highlights: All mirrors have been fabricated, polished, and gold-coated; the mirror is expected to be diffraction-limite d down to a wavelength of 2 micron. The MIRI instrument just complete d its cryogenic testing. STScI has released exposure time calculators and sensitivity charts to enable scientists to start thinking about how to use JWST for their science.

  2. MEMS microshutter arrays for James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Li, Mary J.; Adachi, Tomoko; Allen, Christine; Babu, Sachi; Bajikar, Sateesh; Beamesderfer, Michael; Bradley, Ruth; Denis, Kevin; Costen, Nick; Ewin, Audrey; Franz, David; Hess, Larry; Hu, Ron; Jackson, Kamili M.; Jhabvala, Murzy; Kelly, Dan; King, Todd; Kletetschka, Gunther; Kutyrev, Alexander; Lynch, Barney; Miller, Timothy; Moseley, Harvey, Jr.; Mikula, Vilem; Mott, Brent; Oh, Lance; Pontius, James T.; Rapchun, David; Ray, Chris; Schulte, Eric; Schwinger, Scott; Shu, Peter; Silverberg, Robert; Smith, Wayne; Snodgrass, Steve; Sohl, David; Sparr, Leroy; Steptoe-Jackson, Rosalind; Veronica, Valeriano; Wang, Liqin; Zheng, Yun; Zincke, Chris

    2006-12-01

    MEMS microshutter arrays (MSAs) are being developed at NASA Goddard Space Flight Center for use as an aperture array for the Near-Infrared Spectrometer (NirSpec). The instruments will be carried on the James Webb Space Telescope (JWST), the next generation of space telescope after Hubble Space Telescope retires. The microshutter arrays are designed for the selective transmission of light with high efficiency and high contrast. Arrays are close-packed silicon nitride membranes with a pixel size of 105x204 μm. Individual shutters are patterned with a torsion flexure permitting shutters to open 90 degrees with a minimized mechanical stress concentration. Light shields are made on each shutter for light leak prevention to enhance optical contrast. Shutters are actuated magnetically, latched and addressed electrostatically. The shutter arrays are fabricated using MEMS technologies. Single-side indium flip chip bonding is performed to attach microshutter arrays to substrates.

  3. STS-83 Mission Commander James D. Halsell, Jr. suits up

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-83 Mission Commander James D. Halsell, Jr., gives a thumbs-up after he is assisted into his launch/entry suit in the Operations and Checkout (O&C) Building. Halsell is on his third space flight, having served as pilot of both STS-74 and STS-65. He is a lieutenant colonel in the Air Force and a former SR-71 Blackbird test pilot and holds master's degrees in management and space operations. Halsell will have responsibility for the success of the mission and will operate and maintain Columbia during the Red, or second shift. He will also assist with a materials science experiment and a protein crystal growth payload during the 16-day mission. Halsell and six fellow crew members will shortly depart the O&C and head for Launch Pad 39A, where the Space Shuttle Columbia will lift off during a launch window that opens at 2:00 p.m. EST, April 4.

  4. Apollo 8 Astronaut James Lovell On Phone With President Johnson

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Apollo 8 Astronaut James Lovell, Command Module (CM) pilot of the first manned Saturn V space flight into Lunar orbit, accepted a phone call from the U.S. President Lyndon B. Johnson prior to launch. Lovell, along with astronauts William Anders, Lunar Module (LM) pilot, and Frank Borman, commander, launched aboard the Apollo 8 mission on December 21, 1968 and returned safely to Earth on December 27, 1968. The mission achieved operational experience and tested the Apollo command module systems, including communications, tracking, and life-support, in cis-lunar space and lunar orbit, and allowed evaluation of crew performance on a lunar orbiting mission. The crew photographed the lunar surface, both far side and near side, obtaining information on topography and landmarks as well as other scientific information necessary for future Apollo landings. All systems operated within allowable parameters and all objectives of the mission were achieved.

  5. Solar System Observations with the James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Norwood, James; Hammel, Heidi; Milam, Stefanie; Stansberry, John; Lunine, Jonathan; Chanover, Nancy; Hines, Dean; Sonneborn, George; Tiscareno, Matthew; Brown, Michael; Ferruit, Pierre

    2016-02-01

    The James Webb Space Telescope (JWST) will enable a wealth of new scientific investigations in the near- and mid-infrared, with sensitivity and spatial/spectral resolution greatly surpassing its predecessors. In this paper, we focus upon Solar System science facilitated by JWST, discussing the most current information available concerning JWST instrument properties and observing techniques relevant to planetary science. We also present numerous example observing scenarios for a wide variety of Solar System targets to illustrate the potential of JWST science to the Solar System community. This paper updates and supersedes the Solar System white paper published by the JWST Project in 2010. It is based both on that paper and on a workshop held at the annual meeting of the Division for Planetary Sciences in Reno, NV, in 2012.

  6. Launch Window Trade Analysis for the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Yu, Wayne H.; Richon, Karen

    2014-01-01

    The James Webb Space Telescope (JWST) is a large-scale space telescope mission designed to study fundamental astrophysical questions ranging from the formation of the universe to the origin of planetary systems and the origins of life. JWSTs orbit design is a Libration Point Orbit (LPO) around the Sun-Earth/Moon (SEM) L2 point for a planned mission lifetime of 10.5 years. The launch readiness period for JWST is from Oct 1st, 2018 November 30th, 2018. This paper presents the first launch window analysis for the JWST observatory using finite-burn modeling; previous analysis assumed a single impulsive midcourse correction to achieve the mission orbit. The physical limitations of the JWST hardware stemming primarily from propulsion, communication and thermal requirements alongside updated mission design requirements result in significant launch window within the launch readiness period. Future plans are also discussed.

  7. James Webb Space Telescope Launch Window Trade Analysis

    NASA Technical Reports Server (NTRS)

    Yu, Wayne; Richon, Karen

    2014-01-01

    The James Webb Space Telescope (JWST) is a large-scale space telescope mission designed to study fundamental astrophysical questions ranging from the formation of the universe to the origin of planetary systems and the origins of life. JWSTs orbit design is a Libration Point Orbit (LPO) around the Sun-EarthMoon (SEM) L2 point for a planned mission lifetime of 10.5 years. The launch readiness period for JWST is from Oct 1st, 2018 November 30th, 2018. This paper presents the first launch window analysis for the JWST observatory using finite-burn modeling; previous analysis assumed a single impulsive midcourse correction to achieve the mission orbit. The physical limitations of the JWST hardware stemming primarily from propulsion, communication and thermal requirements alongside updated mission design requirements result in significant launch window within the launch readiness period. Future plans are also discussed.

  8. MEMS Microshutter Arrays for James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Li, Mary J.; Beamesderfer, Michael; Babu, Sachi; Bajikar, Sateesh; Ewin, Audrey; Franz, Dave; Hess, Larry; Hu, Ron; Jhabvala, Murzy; Kelly, Dan; King, Todd; Kletetschkar, Gunther; Kutyrev, Alexander; Lynch, Barney; Moseley, Harvey; Mott, Brent; Oh, Lance; Rapchum, Dave; Ray, Chris; Sappington, Carol; Silverberg, Robert; Smith, Wayne; Snodgrass, Steve; Steptoe-Jackson, Rosalind; Valeriano

    2006-01-01

    MEMS microshutter arrays are being developed at NASA Goddard Space Flight Center for use as an aperture array for a Near-Infrared Spectrometer (NirSpec). The instruments will be carried on the James Webb Space Telescope (JWST), the next generation of space telescope after Hubble Space Telescope retires. The microshutter arrays are designed for the selective transmission of light with high efficiency and high contrast, Arrays are close-packed silicon nitride membranes with a pixel size of 100x200 microns. Individual shutters are patterned with a torsion flexure permitting shutters to open 90 degrees with a minimized mechanical stress concentration. Light shields are made on to each shutter for light leak prevention so to enhance optical contrast, Shutters are actuated magnetically, latched and addressed electrostatically. The shutter arrays are fabricated using MEMS technologies.

  9. James McHenry, MD: physician, patriot, politician and poet.

    PubMed

    Spiegel, Allen D; Kavaler, Florence

    2003-08-01

    James McHenry emigrated from Ireland to the American colonies in 1771. He studied medicine with Dr. Benjamin Rush in Philadelphia and immediately volunteered as an Army surgeon when the Revolutionary War began. After serving in the medical department in Massachusetts, New York and at Valley Forge in Pennsylvania, he became an aide to General George Washington and subsequently an aide to the Marquis de Lafayette. President Washington appointed McHenry Secretary of War and he continued in that post under president John Adams. While Secretary, he revised military regulations, established a professional standing Army, pacified the Indians, enlarged the naval forces, organized the armed forces under civilian authority and initiated plans for a military academy. Baltimore's Fort Whetstone was renamed Fort McHenry in his honor. During the War of 1812, Fort McHenry gained fame as the birthplace of the national anthem of the United States. PMID:12856797

  10. Overview of the James Webb Space Telescope Observatory

    NASA Technical Reports Server (NTRS)

    Clampin, Mark; Smith, Eric P.

    2011-01-01

    The James Webb Space Telescope (JWST) is a large aperture, space telescope designed to provide imaging and spectroscopy from 1.0 micron to 28 microns. JWST will be launched to an orbit at L2 aboard an Ariane 5 launcher in 2013. The Goddard Space Flight Center (GSFC) is the lead center for the JWST program and manages the project for NASA. The prime contractor for JWST is Northrop Grumman Aerospace Systems (NGST). JWST is an international partnership with the European Space Agency (ESA), and the Canadian Space Agency (CSA). ESA will contribute the Ariane 5 launch, and a multi-object infrared spectrograph. CSA will contribute the Fine Guidance Sensor (FGS), which includes the Tunable Filter Imager (TFI). The European consortium, in collaboration with the Jet Propulsion Laboratory (JPL), builds the mid-infrared imager (MIRI). In this paper we present an overview of the JWST science program, and discuss recent progress in the development of the observatory.

  11. Transit Imaging and Spectroscopy with the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    Clampin, Mark

    2008-01-01

    The James Webb Space Telescope (JWST) is a large aperture (6.5 meter), cryogenic space telescope with a suite of near and mid-infrared instruments covering the wavelength range of 0.6 microns to 28 microns. JWST's primary science goal is to detect and characterize the first galaxies. It will also study the assembly of galaxies, star formation, and the formation of evolution of planetary systems. Recent progress in hardware development for the observatory will be presented, including a discussion of the status of JWST's optical system and Beryllium mirror fabrication, progress with sunshield prototypes, and recent changes in the integration and test configuration. We also review the expected scientific performance of the observatory for observations of exosolar planets by means of transit imaging and spectroscopy. We will review the capabilities of each science instrument, and discuss the performance of each mode, with reference to current transiting systems.

  12. James Cameron discusses record dive and science concerns

    NASA Astrophysics Data System (ADS)

    Showstack, Randy; Balcerak, Ernie

    2012-12-01

    James Cameron, the explorer and filmmaker, led a 4 December panel at the AGU Fall Meeting in San Francisco to discuss his daring dive on 26 March to the bottom of the ocean in a one-person vertical "torpedo" submarine, the Deepsea Challenger, and to present some initial science findings from expedition samples and data. The dive touched the bottom of the Challenger Deep, a valley in the floor of the nearly 11-kilometer-deep Mariana Trench in the western Pacific Ocean. The vessel landed close to the same depth and at a location similar to where Don Walsh and Jacques Piccard descended in the Trieste bathyscaphe on 23 January 1960 at a then record-setting depth of 10,911 meters.

  13. The James Webb Space Telescope: Capabilities for Exoplanet Science

    NASA Technical Reports Server (NTRS)

    Clampin, Mark

    2011-01-01

    The James Webb Space Telescope (JWST) is a large aperture (6.5 meter), cryogenic space telescope with a suite of near and mid-infrared instruments covering the wavelength range of 0.6 micron to 28 micron. JWST's primary science goal is to detect and characterize the first galaxies. It will also study the assembly of galaxies, stellar and planetary system formation, and the formation and evolution of planetary systems. We will review the design of JWST, and discuss the current status of the project, with emphasis on recent progress in the construction of the observatory. We also review the capabilities of the observatory for observations of exosolar planets and debris disks by means of coronagraphic imaging, and high contrast imaging and spectroscopy. This discussion will focus on the optical and thermal performance of the observatory, and will include the current predictions for the performance of the observatory, with special reference to the demands of exoplanet science observations.

  14. Giant Planet Observations with the James Webb Space Telescope

    NASA Astrophysics Data System (ADS)

    Norwood, James; Moses, Julianne; Fletcher, Leigh N.; Orton, Glenn; Irwin, Patrick G. J.; Atreya, Sushil; Rages, Kathy; Cavalié, Thibault; Sánchez-Lavega, Agustin; Hueso, Ricardo; Chanover, Nancy

    2016-01-01

    This white paper examines the benefit of the upcoming James Webb Space Telescope (JWST) for studies of the Solar System's four giant planets: Jupiter, Saturn, Uranus, and Neptune. JWST's superior sensitivity, combined with high spatial and spectral resolution, will enable near- and mid-infrared imaging and spectroscopy of these objects with unprecedented quality. In this paper, we discuss some of the myriad scientific investigations possible with JWST regarding the giant planets. This discussion is preceded by the specifics of JWST instrumentation most relevant to giant-planet observations. We conclude with identification of desired pre-launch testing and operational aspects of JWST that would greatly benefit future studies of the giant planets.

  15. Artist's Concept of the James Webb Space Telescope

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Pictured is the chosen artist's rendering of NASA's next generation space telescope, a successor to the Hubble Space Telescope, was named the James Webb Space Telescope (JWST) in honor of NASA's second administrator, James E. Webb. To further our understanding of the way our present universe formed following the the big bang, NASA is developing the JWST to observe the first stars and galaxies in the universe. This grand effort will help to answer the following fundamental questions: How galaxies form and evolve, how stars and planetary systems form and interact, how the universe builds up its present elemental/chemical composition, and what dark matter is. To see into the depths of space, the JWST is currently plarning to carry instruments that are sensitive to the infrared wavelengths of the electromagnetic spectrum. The new telescope will carry a near-infrared camera, a multi-object spectrometer, and a mid-infrared camera/spectrometer. The JWST is scheduled for launch in 2010 aboard an expendable launch vehicle. It will take about 3 months for the spacecraft to reach its destination, an orbit of 940,000 miles in space. Marshall Space Flight Center (MSFC) is supporting Goddard Space Flight Center (GSFC) in developing the JWST by creating an ultra-lightweight mirror for the telescope at MSFC's Space Optics Manufacturing Technology Center. GSFC, Greenbelt, Maryland, manages the JWST, and TRW will design and fabricate the observatory's primary mirror and spacecraft. The program has a number of industry, academic, and government partners, as well as the European Space Agency and the Canadian Space Agency. (Image: Courtesy of TRW)

  16. Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate de novo Assembly of Heterochromatin

    PubMed Central

    Larin, Michelle L.; Harding, Katherine; Williams, Elizabeth C.; Lianga, Noel; Doré, Carole; Pilon, Sophie; Langis, Éric; Yanofsky, Corey; Rudner, Adam D.

    2015-01-01

    Changes in the locations and boundaries of heterochromatin are critical during development, and de novo assembly of silent chromatin in budding yeast is a well-studied model for how new sites of heterochromatin assemble. De novo assembly cannot occur in the G1 phase of the cell cycle and one to two divisions are needed for complete silent chromatin assembly and transcriptional repression. Mutation of DOT1, the histone H3 lysine 79 (K79) methyltransferase, and SET1, the histone H3 lysine 4 (K4) methyltransferase, speed de novo assembly. These observations have led to the model that regulated demethylation of histones may be a mechanism for how cells control the establishment of heterochromatin. We find that the abundance of Sir4, a protein required for the assembly of silent chromatin, decreases dramatically during a G1 arrest and therefore tested if changing the levels of Sir4 would also alter the speed of de novo establishment. Halving the level of Sir4 slows heterochromatin establishment, while increasing Sir4 speeds establishment. yku70Δ and ubp10Δ cells also speed de novo assembly, and like dot1Δ cells have defects in subtelomeric silencing, suggesting that these mutants may indirectly speed de novo establishment by liberating Sir4 from telomeres. Deleting RIF1 and RIF2, which suppresses the subtelomeric silencing defects in these mutants, rescues the advanced de novo establishment in yku70Δ and ubp10Δ cells, but not in dot1Δ cells, suggesting that YKU70 and UBP10 regulate Sir4 availability by modulating subtelomeric silencing, while DOT1 functions directly to regulate establishment. Our data support a model whereby the demethylation of histone H3 K79 and changes in Sir4 abundance and availability define two rate-limiting steps that regulate de novo assembly of heterochromatin. PMID:26587833

  17. CLIF–SOFA score and SIRS are independent prognostic factors in patients with hepatic encephalopathy due to alcoholic liver cirrhosis

    PubMed Central

    Jeong, Jin Hee; Park, In Sung; Kim, Dong Hoon; Kim, Seong Chun; Kang, Changwoo; Lee, Soo Hoon; Kim, Tae Yun; Lee, Sang Bong

    2016-01-01

    Abstract Hepatic encephalopathy (HE) is a complication associated with worst prognosis in decompensated liver cirrhosis (LC) patients. Previous studies have identified prognostic factors for HE, and recent studies reported an association between systemic inflammatory response syndrome (SIRS) and liver disease. This study aimed to identify prognostic factors for 30-day mortality in alcoholic LC patients with HE who visited the emergency department (ED). This was a retrospective study of alcoholic LC patients with HE from January 1, 2010, to April 30, 2015. The baseline characteristics, complications of portal hypertension, laboratory values, Child–Pugh class, Model for End-stage Liver Disease (MELD) score, chronic liver failure-sequential organ failure assessment (CLIF–SOFA) score, and SIRS criteria were assessed. The presence of 2 or more SIRS criteria was considered SIRS. The primary outcomes were 30-day mortality and prognostic factors for patients with HE visiting the ED. In total, 105 patients who met the inclusion criteria were analyzed. Overall, the 30-day mortality rate was 6.7% (7 patients). Significant variables were hepatorenal syndrome, international normalized ratio, white blood cell count, total bilirubin level, MELD score CLIF–SOFA score, and SIRS in univariate analysis. CLIF–SOFA score and SIRS were the significant factors in the multivariate analysis (hazard ratio 5.56, 15.98; 95% confidence interval 1.18–26.18, 1.58–161.37; P = 0.03, P = 0.02). The mortality rates differed according to the CLIF–SOFA score (P < 0.01). The CLIF–SOFA score and SIRS in alcoholic LC patients with HE visiting the ED are independent predictors of 30-day mortality. PMID:27367990

  18. The Italian SEPSIS study: preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock.

    PubMed

    Salvo, I; de Cian, W; Musicco, M; Langer, M; Piadena, R; Wolfler, A; Montani, C; Magni, E

    1995-11-01

    This prospective, multicenter, epidemiological study was carried out in 99 Italian ICUs, distributed throughout the country, from April 1993 to March 1994. In the study, we applied the new ACCP/SCCM classification system for sepsis (SIRS, sepsis, severe sepsis and septic shock) and determined the prevalence, incidence, evolution and outcome of these categories in critically ill patients. The preliminary analysis of 1101 patients showed that on admission SIRS accounted for about half of the diagnoses (52%) with sepsis, severe sepsis and septic shock accounting for 4.5%, 2.1% and 3% of patients, respectively. Patients with severe sepsis or septic shock more frequently had high SAPS scores than patients without sepsis. Mortality rates were similar in patients with SIRS (26.5%) and without SIRS or infection (24%), but rose to 36% in patients with sepsis, to 52% in those with severe sepsis and to 81.8% in those with septic shock. Sepsis, severe sepsis and septic shock were more common in patients with medical diagnoses, and neither severe sepsis nor septic shock was observed in trauma patients. With respect to evolution, the incidence of septic shock was progressively higher in patients admitted with more severe "sepsis-related" diagnoses, while only a trivial difference in rates of incidence was observed between SIRS patients and those admitted without SIRS or any septic disorder (nil). The breakdown of the various ACCP/SCCM "sepsis-related" diagnoses at any time during the study was: SIRS in 58% of the population, sepsis in 16.3%, severe sepsis in 5.5% and septic shock in 6.1%. It seems reasonable to expect from the final evaluation of our study answers to the questions raised by the ACCP/SCCM Consensus Conference about the correlations between "sepsis-related" diagnosis, severity score, organ dysfunction score and outcome. PMID:8636531

  19. 75 FR 59237 - TRICARE Co-Pay Waiver at Captain James A. Lovell Federal Health Care Center Demonstration Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ... of the Secretary TRICARE Co-Pay Waiver at Captain James A. Lovell Federal Health Care Center... waiver at Captain James A. Lovell Federal Health Care Center demonstration project. SUMMARY: This notice... Captain James A. Lovell Federal Health Care (FHCC) Demonstration Project.'' Under this...

  20. 75 FR 14637 - James A. FitzPatrick Nuclear Power Plant; Environmental Assessment and Finding of No Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ... COMMISSION James A. FitzPatrick Nuclear Power Plant; Environmental Assessment and Finding of No Significant...), for the operation of the James A. FitzPatrick Nuclear Power Plant (JAFNPP) located in Oswego County... related to operation of James A. FitzPatrick Nuclear Power Plant Power Authority of the State of New...