Science.gov

Sample records for skewness

  1. Skew chromaticity

    SciTech Connect

    Peggs, S.; Dell, G.F.

    1994-12-31

    The on-momentum description of linear coupling between horizontal and vertical betatron motion is extended to include off-momentum particles, introducing a vector quantity called the ``skew chromaticity``. This vector tends to be long in large superconducting storage rings, where it restricts the available working space in the tune plane, and modifies collective effect stability criteria. Skew chromaticity measurements at the Cornell Electron Storage Ring (CESR) and at the Fermilab Tevatron are reported, as well as tracking results from the Relativistic Heavy Ion Collider (RHIC). The observation of anomalous head-tail beam Iowa new the tune diagonal in the Tevatron are explained in terms of the extended theory, including modified criteria for headtail stability. These results are confirmed in head-tail simulations. Sources of skew chromaticity are investigated.

  2. Quantum skew divergence

    SciTech Connect

    Audenaert, Koenraad M. R.

    2014-11-15

    In this paper, we study the quantum generalisation of the skew divergence, which is a dissimilarity measure between distributions introduced by Lee in the context of natural language processing. We provide an in-depth study of the quantum skew divergence, including its relation to other state distinguishability measures. Finally, we present a number of important applications: new continuity inequalities for the quantum Jensen-Shannon divergence and the Holevo information, and a new and short proof of Bravyi's Small Incremental Mixing conjecture.

  3. Image fiber skew characteristics

    NASA Astrophysics Data System (ADS)

    Nakamura, Moriya; Otsubo, Toshimichi; Kitayama, Ken-ichi

    2000-04-01

    Skew of an image fiber, which has more than ten thousands of cores in a common cladding, was measured by a novel measurement method for the first time. This method can measure the time-of-flight difference between individual cores over the whole area of an image circle. The measurement results reveals that a test 100-m-long image fiber has skew of 5 ps/m, and the time-of-flight distributes randomly in the whole area of the image circle due to nonuniformity of the core dimension. It is also experimentally shown that the skew of an image fiber increases by bending. The theoretical analysis reveals that the bending-induced skew depends neither on the radius of curvature nor the shape of the curve but it depends only on the number of turns it is wound. The numerical calculation of skew by using typical parameters of image fibers shows that the winding have to be restricted to less than 12.5 turns to achieve a transmission speed of over 1 Gbps/ch. Lastly we propose twisted image fiber and a 8-shaped bobbin to suppress the skew due to bending.

  4. Skew mapping cataclysmic variables

    NASA Astrophysics Data System (ADS)

    Smith, R. C.; Vande Putte, D.

    2002-01-01

    The secondary in CVs is usually detected by correlation of the spectrum with that of a red dwarf template, to produce a radial velocity curve. This method has demonstrated its power, but has limits in case of noisy spectra, as in faint secondaries. To circumvent this difficulty, a method of co-adding spectra, called skew mapping, has been proposed in the past. This paper explores the capabilities of skew mapping in determining the amplitude of the radial velocity for faint secondaries. We record our appreciation to Dr T. R. Marsh for advice on his ``molly'' code. Thanks are due to the observers and data reducers (D. H. P. Jones, N. A. Hawkins, J. Thorstensen, and J. S. Martin).

  5. Measuring Skewness: A Forgotten Statistic?

    ERIC Educational Resources Information Center

    Doane, David P.; Seward, Lori E.

    2011-01-01

    This paper discusses common approaches to presenting the topic of skewness in the classroom, and explains why students need to know how to measure it. Two skewness statistics are examined: the Fisher-Pearson standardized third moment coefficient, and the Pearson 2 coefficient that compares the mean and median. The former is reported in statistical…

  6. Skew resisting hydrodynamic seal

    DOEpatents

    Conroy, William T.; Dietle, Lannie L.; Gobeli, Jeffrey D.; Kalsi, Manmohan S.

    2001-01-01

    A novel hydrodynamically lubricated compression type rotary seal that is suitable for lubricant retention and environmental exclusion. Particularly, the seal geometry ensures constraint of a hydrodynamic seal in a manner preventing skew-induced wear and provides adequate room within the seal gland to accommodate thermal expansion. The seal accommodates large as-manufactured variations in the coefficient of thermal expansion of the sealing material, provides a relatively stiff integral spring effect to minimize pressure-induced shuttling of the seal within the gland, and also maintains interfacial contact pressure within the dynamic sealing interface in an optimum range for efficient hydrodynamic lubrication and environment exclusion. The seal geometry also provides for complete support about the circumference of the seal to receive environmental pressure, as compared the interrupted character of seal support set forth in U.S. Pat. Nos. 5,873,576 and 6,036,192 and provides a hydrodynamic seal which is suitable for use with non-Newtonian lubricants.

  7. Skew-normal antedependence models for skewed longitudinal data

    PubMed Central

    Chang, Shu-Ching; Zimmerman, Dale L.

    2016-01-01

    Antedependence models, also known as transition models, have proven to be useful for longitudinal data exhibiting serial correlation, especially when the variances and/or same-lag correlations are time-varying. Statistical inference procedures associated with normal antedependence models are well-developed and have many nice properties, but they are not appropriate for longitudinal data that exhibit considerable skewness. We propose two direct extensions of normal antedependence models to skew-normal antedependence models. The first is obtained by imposing antedependence on a multivariate skew-normal distribution, and the second is a sequential autoregressive model with skew-normal innovations. For both models, necessary and sufficient conditions for \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$p$\\end{document}th-order antedependence are established, and likelihood-based estimation and testing procedures for models satisfying those conditions are developed. The procedures are applied to simulated data and to real data from a study of cattle growth. PMID:27279663

  8. Skew chromaticity in large accelerators

    SciTech Connect

    Peggs, S.; Dell, G.F.

    1995-05-01

    The 2-D ``skew chromaticity`` vector k is introduced when the standard on-momentum description of linear coupling is extended to include off-momentum particles. A lattice that is well decoupled on-momentum may be badly decoupled off-momentum, inside the natural momentum spread of the beam. There are two general areas of concern: (1) the free space in the tune plane is decreased; (2) collective phenomena may be destabilized. Two strong new criteria for head-tail stability in the presence of off-momentum coupling are derived, which are consistent with experimental and operational observations at the Tevatron, and with tracking data from RHIC.

  9. Kinematic correction for roller skewing

    NASA Technical Reports Server (NTRS)

    Savage, M.; Loewenthal, S. H.

    1980-01-01

    A theory of kinematic stabilization of rolling cylinders is developed for high-speed cylindrical roller bearings. This stabilization requires race and roller crowning to product changes in the rolling geometry as the roller shifts axially. These changes put a reverse skew in the rolling elements by changing the rolling taper. Twelve basic possible bearing modifications are identified in this paper. Four have single transverse convex curvature in the rollers while eight have rollers with compound transverse curvature composed of a central cylindrical band of constant radius surrounded by symmetric bands with both slope and transverse curvature.

  10. Mixture of Skewed α-Stable Distributions

    NASA Astrophysics Data System (ADS)

    Shojaei, S. R. Hosseini; Nassiri, V.; Mohammadian, Gh. R.; Mohammadpour, A.

    2011-03-01

    Expectation maximization (EM) algorithm and the Bayesian techniques are two approaches for statistical inference of mixture models [3, 4]. By noting the advantages of the Bayesian methods, practitioners prefer them. However, implementing Markov chain Monte Carlo algorithms can be very complicated for stable distributions, due to the non-analytic density or distribution function formulas. In this paper, we introduce a new class of mixture of heavy-tailed distributions, called mixture of skewed stable distributions. Skewed stable distributions belongs to the exponential family and they have analytic density representation. It is shown that skewed stable distributions dominate skew stable distribution functions and they can be used to model heavy-tailed data. The class of skewed stable distributions has an analytic representation for its density function and the Bayesian inference can be done similar to the exponential family of distributions. Finally, mixture of skewed stable distributions are compared to the mixture of stable distributions through a simulations study.

  11. Comparative study of skew detection algorithms

    NASA Astrophysics Data System (ADS)

    Amin, Adnan; Fischer, Stephen; Parkinson, Anthony F.; Shiu, Ricky

    1996-10-01

    Document image processing has become an increasingly important technology in the automation of office documentation tasks. Automatic document scanners such as text readers and optical character recognition systems are an essential component of systems capable of those tasks. One of the problems in this field is that the document to be read is not always placed correctly on a flat-bed scanner. This means that the document may be skewed on the scanner bed, resulting in a skewed image. This skew has a detrimental effect on document analysis, document understanding, and character segmentation and recognition. Consequently, detecting the skew of a document image and correcting it are important issues in realizing a practical document reader. We describe a new algorithm for skew detection. We then compare the performance and results of this skew detection algorithm to other published methods from O'Gorman, Hinds, Le, Baird, Postl, and Akiyama. Finally, we discuss the theory of skew detection and the different approaches taken to solve the problem of skew in documents. The skew correction algorithm we propose has been shown to be extremely fast, with run times averaging under 0.25 CPU seconds to calculate the angle on a DEC 5000/20 workstation.

  12. Roller skewing measurements in cylindrical roller bearings

    NASA Technical Reports Server (NTRS)

    Nypan, L. J.

    1981-01-01

    Measurements of roller skewing in a 118 mm bore roller bearing operating at shaft speeds to 12,000 rpm are reported. High speed motion pictures of a modified roller were taken through a derotation prism to record skewing as the roller moved through loaded and unloaded regions of the bearing. Subsequent frame by frame measurement of the photographic film provided information on roller skewing. Radial and tangential skew amplitudes of 0.4 to 0.5 degrees were observed with 0.5 degree misalignment.

  13. Frequency skewed optical pulses for range detection

    NASA Astrophysics Data System (ADS)

    Ozharar, Sarper; Gee, Sangyoun; Quinlan, Franklyn; Delfyett, Peter J., Jr.

    2007-04-01

    Frequency skewed optical pulses are generated via both a composite cavity structure in a fiberized semiconductor optical amplifier ring laser and a frequency skew loop outside the laser cavity. The composite cavity technique is similar to rational harmonic mode-locking, however it is based on cavity detuning rather than frequency detuning. These frequency skewed pulses are ideal for range detection applications since their interference results in a range dependent RF signal. The intracavity frequency skewed pulse train showed superior performance in both stability and signal quality.

  14. Modeling skewness in human transcriptomes.

    PubMed

    Casellas, Joaquim; Varona, Luis

    2012-01-01

    Gene expression data are influenced by multiple biological and technological factors leading to a wide range of dispersion scenarios, although skewed patterns are not commonly addressed in microarray analyses. In this study, the distribution pattern of several human transcriptomes has been studied on free-access microarray gene expression data. Our results showed that, even in previously normalized gene expression data, probe and differential expression within probe effects suffer from substantial departures from the commonly assumed symmetric gaussian distribution. We developed a flexible mixed model for non-competitive microarray data analysis that accounted for asymmetric and heavy-tailed (Student's t distribution) dispersion processes. Random effects for gene expression data were modeled under asymmetric Student's t distributions where the asymmetry parameter (λ) took values from perfect symmetry (λ = 0) to right- (λ>0) or left-side (λ>0) over-expression patterns. This approach was applied to four free-access human data sets and revealed clearly better model performance when comparing with standard approaches accounting for traditional symmetric gaussian distribution patterns. Our analyses on human gene expression data revealed a substantial degree of right-hand asymmetry for probe effects, whereas differential gene expression addressed both symmetric and left-hand asymmetric patterns. Although these results cannot be extrapolated to all microarray experiments, they highlighted the incidence of skew dispersion patterns in human transcriptome; moreover, we provided a new analytical approach to appropriately address this biological phenomenon. The source code of the program accommodating these analytical developments and additional information about practical aspects on running the program are freely available by request to the corresponding author of this article. PMID:22701729

  15. Portfolio optimization with skewness and kurtosis

    NASA Astrophysics Data System (ADS)

    Lam, Weng Hoe; Jaaman, Saiful Hafizah Hj.; Isa, Zaidi

    2013-04-01

    Mean and variance of return distributions are two important parameters of the mean-variance model in portfolio optimization. However, the mean-variance model will become inadequate if the returns of assets are not normally distributed. Therefore, higher moments such as skewness and kurtosis cannot be ignored. Risk averse investors prefer portfolios with high skewness and low kurtosis so that the probability of getting negative rates of return will be reduced. The objective of this study is to compare the portfolio compositions as well as performances between the mean-variance model and mean-variance-skewness-kurtosis model by using the polynomial goal programming approach. The results show that the incorporation of skewness and kurtosis will change the optimal portfolio compositions. The mean-variance-skewness-kurtosis model outperforms the mean-variance model because the mean-variance-skewness-kurtosis model takes skewness and kurtosis into consideration. Therefore, the mean-variance-skewness-kurtosis model is more appropriate for the investors of Malaysia in portfolio optimization.

  16. Skew-flavored dark matter

    DOE PAGESBeta

    Agrawal, Prateek; Chacko, Zackaria; Fortes, Elaine C. F. S.; Kilic, Can

    2016-05-10

    We explore a novel flavor structure in the interactions of dark matter with the Standard Model. We consider theories in which both the dark matter candidate, and the particles that mediate its interactions with the Standard Model fields, carry flavor quantum numbers. The interactions are skewed in flavor space, so that a dark matter particle does not directly couple to the Standard Model matter fields of the same flavor, but only to the other two flavors. This framework respects minimal flavor violation and is, therefore, naturally consistent with flavor constraints. We study the phenomenology of a benchmark model in whichmore » dark matter couples to right-handed charged leptons. In large regions of parameter space, the dark matter can emerge as a thermal relic, while remaining consistent with the constraints from direct and indirect detection. The collider signatures of this scenario include events with multiple leptons and missing energy. In conclusion, these events exhibit a characteristic flavor pattern that may allow this class of models to be distinguished from other theories of dark matter.« less

  17. Skew-flavored dark matter

    NASA Astrophysics Data System (ADS)

    Agrawal, Prateek; Chacko, Zackaria; Fortes, Elaine C. F. S.; Kilic, Can

    2016-05-01

    We explore a novel flavor structure in the interactions of dark matter with the Standard Model. We consider theories in which both the dark matter candidate, and the particles that mediate its interactions with the Standard Model fields, carry flavor quantum numbers. The interactions are skewed in flavor space, so that a dark matter particle does not directly couple to the Standard Model matter fields of the same flavor, but only to the other two flavors. This framework respects minimal flavor violation and is, therefore, naturally consistent with flavor constraints. We study the phenomenology of a benchmark model in which dark matter couples to right-handed charged leptons. In large regions of parameter space, the dark matter can emerge as a thermal relic, while remaining consistent with the constraints from direct and indirect detection. The collider signatures of this scenario include events with multiple leptons and missing energy. These events exhibit a characteristic flavor pattern that may allow this class of models to be distinguished from other theories of dark matter.

  18. Tunable skewed edges in puckered structures

    NASA Astrophysics Data System (ADS)

    Grujić, Marko M.; Ezawa, Motohiko; Tadić, Milan Ž.; Peeters, François M.

    2016-06-01

    We propose a type of edges arising due to the anisotropy inherent in the puckered structure of a honeycomb system such as in phosphorene. Skewed-zigzag and skewed-armchair nanoribbons are semiconducting and metallic, respectively, in contrast to their normal edge counterparts. Their band structures are tunable, and a metal-insulator transition is induced by an electric field. We predict a field-effect transistor based on the edge states in skewed-armchair nanoribbons, where the edge state is gapped by applying arbitrary small electric field Ez. A topological argument is presented, revealing the condition for the emergence of such edge states.

  19. SKEW QUADRUPOLE FOCUSING LATTICES AND APPLICATIONS.

    SciTech Connect

    PARKER,B.

    2001-06-18

    In this paper we revisit using skew quadrupole fields in place of traditional normal upright quadrupole fields to make beam focusing structures. We illustrate by example skew lattice decoupling, dispersion suppression and chromatic correction using the neutrino factory Study-II muon storage ring design. Ongoing BNL investigation of flat coil magnet structures that allow building a very compact muon storage ring arc and other flat coil configurations that might bring significant magnet cost reduction to a VLHC motivate our study of skew focusing.

  20. Are reproductive skew models evolutionarily stable?

    PubMed Central

    Kokko, Hanna

    2003-01-01

    Reproductive skew theory has become a popular way to phrase problems and test hypotheses of social evolution. The diversity of reproductive skew models probably stems from the ease of generating new variations. However, I show that the logical basis of skew models, that is, the way in which group formation is modelled, makes use of hidden assumptions that may be problematical as they are unlikely to be fulfilled in all social systems. I illustrate these problems by re-analysing the basic concessive skew model with staying incentives. First, the model assumes that dispersal is an all-or-nothing response: all subordinates disperse as soon as concessions drop below a certain value. This leads to a discontinuous 'cliff-edge' shape of dominant fitness, and it is not clear that selection will balance a population at such an edge. Second, it is assumed that subordinates have perfect knowledge of their benefits if they stay in the group. I examine the effects of relaxing these two assumptions. Relaxing the first one strengthens reproductive skew theory, but relaxing the latter makes evolutionary stability disappear. In cases where subordinates cannot accurately measure benefits provided by the individual dominant with which they live, so that their behaviour instead evolves as a response to population-wide average benefits, the logic of reproductive skew models does not apply. This warns against too indiscriminate an application of reproductive skew theory to problems in social evolution: for example, transactional models of extra-pair paternity assume perfect knowledge of paternity, which is unlikely to hold true in nature. It is recommended that models specify the mechanisms by which individuals can adjust their behaviour to that of others, and pay attention to changes that occur in evolutionary versus behavioural time. PMID:12614575

  1. Defining surfaces for skewed, highly variable data

    USGS Publications Warehouse

    Helsel, D.R.; Ryker, S.J.

    2002-01-01

    Skewness of environmental data is often caused by more than simply a handful of outliers in an otherwise normal distribution. Statistical procedures for such datasets must be sufficiently robust to deal with distributions that are strongly non-normal, containing both a large proportion of outliers and a skewed main body of data. In the field of water quality, skewness is commonly associated with large variation over short distances. Spatial analysis of such data generally requires either considerable effort at modeling or the use of robust procedures not strongly affected by skewness and local variability. Using a skewed dataset of 675 nitrate measurements in ground water, commonly used methods for defining a surface (least-squares regression and kriging) are compared to a more robust method (loess). Three choices are critical in defining a surface: (i) is the surface to be a central mean or median surface? (ii) is either a well-fitting transformation or a robust and scale-independent measure of center used? (iii) does local spatial autocorrelation assist in or detract from addressing objectives? Published in 2002 by John Wiley & Sons, Ltd.

  2. Skewness and Kurtosis in Statistical Kinetics

    NASA Astrophysics Data System (ADS)

    Barato, Andre C.; Seifert, Udo

    2015-10-01

    We obtain lower and upper bounds on the skewness and kurtosis associated with the cycle completion time of unicyclic enzymatic reaction schemes. Analogous to a well-known lower bound on the randomness parameter, the lower bounds on skewness and kurtosis are related to the number of intermediate states in the underlying chemical reaction network. Our results demonstrate that evaluating these higher order moments with single molecule data can lead to information about the enzymatic scheme that is not contained in the randomness parameter.

  3. Skew chicane based betatron eigenmode exchange module

    DOEpatents

    Douglas, David

    2010-12-28

    A skewed chicane eigenmode exchange module (SCEEM) that combines in a single beamline segment the separate functionalities of a skew quad eigenmode exchange module and a magnetic chicane. This module allows the exchange of independent betatron eigenmodes, alters electron beam orbit geometry, and provides longitudinal parameter control with dispersion management in a single beamline segment with stable betatron behavior. It thus reduces the spatial requirements for multiple beam dynamic functions, reduces required component counts and thus reduces costs, and allows the use of more compact accelerator configurations than prior art design methods.

  4. Testing multiple hypotheses with skewed alternatives.

    PubMed

    Bansal, Naveen K; Hamedani, Gholamhossein G; Maadooliat, Mehdi

    2016-06-01

    In many practical cases of multiple hypothesis problems, it can be expected that the alternatives are not symmetrically distributed. If it is known a priori that the distributions of the alternatives are skewed, we show that this information yields high power procedures as compared to the procedures based on symmetric alternatives when testing multiple hypotheses. We propose a Bayesian decision theoretic rule for multiple directional hypothesis testing, when the alternatives are distributed as skewed, under a constraint on a mixed directional false discovery rate. We compare the proposed rule with a frequentist's rule of Benjamini and Yekutieli (2005) using simulations. We apply our method to a well-studied HIV dataset. PMID:26536168

  5. Cohomology of skew-holomorphic lie algebroids

    NASA Astrophysics Data System (ADS)

    Bruzzo, U.; Rubtsov, V. N.

    2010-12-01

    We introduce the notion of a skew-holomorphic Lie algebroid on a complex manifold and explore some cohomology theories that can be associated with it. We present examples and applications of this notion in terms of different types of holomorphic Poisson structures.

  6. Bending of skew plates of variable rigidity.

    NASA Technical Reports Server (NTRS)

    Willems, N.; Mahmood, S. S.

    1972-01-01

    Description of an analytical procedure for studying the bending of thin skew plates of a thickness varying in one direction, under arbitrary lateral loading. The analysis was programmed for execution on an electronic computer for various conditions and types of loading. The results obtained suggest that the proposed analytical procedure is more accurate than the finite-difference technique used in earlier investigations.

  7. Standard Mastery Curves and Skew Curves.

    ERIC Educational Resources Information Center

    Warries, Egbert

    The objective of the study is to convince educational researchers of the necessity for "standard mastery curves" for the graphical representation of scores on summative tests for a group of students. Attention is drawn to the study of theoretical and empirical skew curves in education and biology. Use of standard mastery curves and study of skew…

  8. Analysis of Parasite and Other Skewed Counts

    PubMed Central

    Alexander, Neal

    2012-01-01

    Objective To review methods for the statistical analysis of parasite and other skewed count data. Methods Statistical methods for skewed count data are described and compared, with reference to those used over a ten year period of Tropical Medicine and International Health. Two parasitological datasets are used for illustration. Results Ninety papers were identified, 89 with descriptive and 60 with inferential analysis. A lack of clarity is noted in identifying measures of location, in particular the Williams and geometric mean. The different measures are compared, emphasizing the legitimacy of the arithmetic mean for skewed data. In the published papers, the t test and related methods were often used on untransformed data, which is likely to be invalid. Several approaches to inferential analysis are described, emphasizing 1) non-parametric methods, while noting that they are not simply comparisons of medians, and 2) generalized linear modelling, in particular with the negative binomial distribution. Additional methods, such as the bootstrap, with potential for greater use are described. Conclusions Clarity is recommended when describing transformations and measures of location. It is suggested that non-parametric methods and generalized linear models are likely to be sufficient for most analyses. PMID:22943299

  9. Optimal Weak-Lensing Skewness Measurements

    NASA Astrophysics Data System (ADS)

    Zhang, Tong-Jie; Pen, Ue-Li; Zhang, Pengjie; Dubinski, John

    2003-12-01

    Weak-lensing measurements are starting to provide statistical maps of the distribution of matter in the universe that are increasingly precise and complementary to cosmic microwave background maps. The most common measurement is the correlation in alignments of background galaxies, which can be used to infer the variance of the projected surface density of matter. This measurement of the fluctuations is insensitive to the total mass content and is analogous to using waves on the ocean to measure its depths. However, when the depth is shallow, as happens near a beach, waves become skewed. Similarly, a measurement of skewness in the projected matter distribution directly measures the total matter content of the universe. While skewness has already been convincingly detected, its constraint on cosmology is still weak. We address optimal analyses for the Canada-France-Hawaii Telescope Legacy Survey in the presence of noise. We show that a compensated Gaussian filter with a width of 2.5‧ optimizes the cosmological constraint, yielding ΔΩm/Ωm~10%. This is significantly better than other filters that have been considered in the literature. This can be further improved with tomography and other sophisticated analyses.

  10. Generalized skew coefficients for flood-frequency analysis in Minnesota

    USGS Publications Warehouse

    Lorenz, D.L.

    1997-01-01

    This report presents an evaluation of generalized skew coefficients used in flood-frequency analysis. Station skew coefficients were computed for 267 long-term stream-gaging stations in Minnesota and the surrounding states of Iowa, North and South Dakota, Wisconsin, and the provinces of Manitoba and Ontario, Canada. Generalized skew coefficients were computed from station skew coefficients using a locally weighted regression technique. The resulting regression trend surface was the generalized skew coefficient map, except for the North Shore area, and has a mean square error of 0.182.

  11. Dynamic Modeling from Flight Data with Unknown Time Skews

    NASA Technical Reports Server (NTRS)

    Morelli, Eugene A.

    2016-01-01

    A method for estimating dynamic model parameters from flight data with unknown time skews is described and demonstrated. The method combines data reconstruction, nonlinear optimization, and equation-error parameter estimation in the frequency domain to accurately estimate both dynamic model parameters and the relative time skews in the data. Data from a nonlinear F-16 aircraft simulation with realistic noise, instrumentation errors, and arbitrary time skews were used to demonstrate the approach. The approach was further evaluated using flight data from a subscale jet transport aircraft, where the measured data were known to have relative time skews. Comparison of modeling results obtained from time-skewed and time-synchronized data showed that the method accurately estimates both dynamic model parameters and relative time skew parameters from flight data with unknown time skews.

  12. Inferring climate variability from skewed proxy records

    NASA Astrophysics Data System (ADS)

    Emile-Geay, J.; Tingley, M.

    2013-12-01

    Many paleoclimate analyses assume a linear relationship between the proxy and the target climate variable, and that both the climate quantity and the errors follow normal distributions. An ever-increasing number of proxy records, however, are better modeled using distributions that are heavy-tailed, skewed, or otherwise non-normal, on account of the proxies reflecting non-normally distributed climate variables, or having non-linear relationships with a normally distributed climate variable. The analysis of such proxies requires a different set of tools, and this work serves as a cautionary tale on the danger of making conclusions about the underlying climate from applications of classic statistical procedures to heavily skewed proxy records. Inspired by runoff proxies, we consider an idealized proxy characterized by a nonlinear, thresholded relationship with climate, and describe three approaches to using such a record to infer past climate: (i) applying standard methods commonly used in the paleoclimate literature, without considering the non-linearities inherent to the proxy record; (ii) applying a power transform prior to using these standard methods; (iii) constructing a Bayesian model to invert the mechanistic relationship between the climate and the proxy. We find that neglecting the skewness in the proxy leads to erroneous conclusions and often exaggerates changes in climate variability between different time intervals. In contrast, an explicit treatment of the skewness, using either power transforms or a Bayesian inversion of the mechanistic model for the proxy, yields significantly better estimates of past climate variations. We apply these insights in two paleoclimate settings: (1) a classical sedimentary record from Laguna Pallcacocha, Ecuador (Moy et al., 2002). Our results agree with the qualitative aspects of previous analyses of this record, but quantitative departures are evident and hold implications for how such records are interpreted, and

  13. Temperature-Compensated Clock Skew Adjustment

    PubMed Central

    Castillo-Secilla, Jose María; Palomares, Jose Manuel; Olivares, Joaquín

    2013-01-01

    This work analyzes several drift compensation mechanisms in wireless sensor networks (WSN). Temperature is an environmental factor that greatly affects oscillators shipped in every WSN mote. This behavior creates the need of improving drift compensation mechanisms in synchronization protocols. Using the Flooding Time Synchronization Protocol (FTSP), this work demonstrates that crystal oscillators are affected by temperature variations. Thus, the influence of temperature provokes a low performance of FTSP in changing conditions of temperature. This article proposes an innovative correction factor that minimizes the impact of temperature in the clock skew. By means of this factor, two new mechanisms are proposed in this paper: the Adjusted Temperature (AT) and the Advanced Adjusted Temperature (A2T). These mechanisms have been combined with FTSP to produce AT-FTSP and A2T-FTSP Both have been tested in a network of TelosB motes running TinyOS. Results show that both AT-FTSP and A2T-FTSP improve the average synchronization errors compared to FTSP and other temperature-compensated protocols (Environment-Aware Clock Skew Estimation and Synchronization for WSN (EACS) and Temperature Compensated Time Synchronization (TCTS)). PMID:23966192

  14. Prediction of performance of large synchronous machines with skewed stators

    NASA Astrophysics Data System (ADS)

    Troitskaia, Svetlana G.

    Large synchronous machines produce the majority of electric energy in Canada. To improve quality of the electric energy, manufacturers skew stators of these machines, Skewing causes axial shifting of magnetic fields, so that power losses in these machines differ from the losses in unskewed machines Numerical methods are incapable of analyzing a large skewed machine in a reasonable time. To evaluate losses, fast simulation tools have been needed to aid designers of skewed synchronous generators at a preliminary stage of design. This work is devoted to analytical modeling of harmonic magnetic fields, harmonic currents and high-frequency energy losses in large synchronous generators with skewed stators. A fast and accurate simulation tool has been developed on the basis of the model; it can be used for preliminary design of a skewed synchronous machine.

  15. Modelling Scalar Skewness in Cloudy Boundary Layers

    NASA Astrophysics Data System (ADS)

    Mironov, Dmitrii; Machulskaya, Ekaterina; Naumann, Ann Kristin; Seifert, Axel; Mellado, Juan Pedro

    2015-04-01

    Following the pioneering work of Sommeria and Deardorff (1977), statistical cloud schemes are widely used in numerical weather prediction (NWP) and climate models to parameterize the effect of shallow clouds on turbulent mixing and radiation fluxes. Statistical cloud schemes compute the cloud fraction, the amount of cloud condensate and the effect clouds on the buoyancy flux in a given atmospheric-model grid box. This is done with due regard for the sub-grid scale (SGS) fluctuations of temperature and humidity (and possibly the vertical velocity), thus providing an important coupling between cloudiness and the SGS mixing processes. The shape of the PDF of fluctuating fields is assumed, whereas the PDF moments should be provided to the cloud scheme as an input. For non-precipitation clouds, the mixing schemes are usually formulated in terms of quasi-conservative variable, e.g. the liquid (total) water potential temperature and the total water specific humidity. Then, the cloud schemes are conveniently cast in terms of the linearized saturation deficit, referred to as the "s" variable (Mellor 1977), that accounts for the combined effect of the two scalars. If a simple two-parameter single-Gaussian PDF is used, the only "turbulence" parameter to be provided to the cloud scheme is the variance of s. The single-Gaussian PDF ignores the skewed nature of SGS motions and fails to describe many important regimes, e.g. shallow cumuli. A number of more flexible skewed PDFs have been proposed to date. A three-parameter PDF, based on a double-Gaussian distribution and diagnostic relations between some PDF parameters derived from LES and observational data (Naumann et al. 2013), appears to be a good compromise between physical realism and computational economy. A crucial point is that the cloud schemes using non-Gaussian PDFs require the scalar skewness as an input. Using rather mild non-restrictive assumptions, we develop a transport equation for the s-variable triple

  16. Underside of span over Pickering Creek, showing highly skewed piers, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Underside of span over Pickering Creek, showing highly skewed piers, looking south. - Pennsylvania Railroad, Pickering Creek Trestle, Spanning Pickering Creek, south of Buckwalter Road, Pickering, Chester County, PA

  17. Cracked shells under skew-symmetric loading

    NASA Technical Reports Server (NTRS)

    Lelale, F.

    1982-01-01

    A shell containing a through crack in one of the principal planes of curvature and under general skew-symmetric loading is considered. By employing a Reissner type shell theory which takes into account the effect of transverse shear strains, all boundary conditions on the crack surfaces are satisfied separately. Consequently, unlike those obtained from the classical shell theory, the angular distributions of the stress components around the crack tips are shown to be identical to the distributions obtained from the plane and antiplane elasticity solutions. Extensive results are given for axially and circumferentially cracked cylindrical shells, spherical shells, and toroidal shells under uniform inplane shearing, out of plane shearing, and torsion. The effect of orthotropy on the results is also studied.

  18. Evolution of the derivative skewness for nonlinearly propagating waves.

    PubMed

    Reichman, Brent O; Muhlestein, Michael B; Gee, Kent L; Neilsen, Tracianne B; Thomas, Derek C

    2016-03-01

    The skewness of the first time derivative of a pressure waveform, or derivative skewness, has been used previously to describe the presence of shock-like content in jet and rocket noise. Despite its use, a quantitative understanding of derivative skewness values has been lacking. In this paper, the derivative skewness for nonlinearly propagating waves is investigated using analytical, numerical, and experimental methods. Analytical expressions for the derivative skewness of an initially sinusoidal plane wave are developed and, along with numerical data, are used to describe its behavior in the preshock, sawtooth, and old-age regions. Analyses of common measurement issues show that the derivative skewness is relatively sensitive to the effects of a smaller sampling rate, but less sensitive to the presence of additive noise. In addition, the derivative skewness of nonlinearly propagating noise is found to reach greater values over a shorter length scale relative to sinusoidal signals. A minimum sampling rate is recommended for sinusoidal signals to accurately estimate derivative skewness values up to five, which serves as an approximate threshold indicating significant shock formation. PMID:27036276

  19. A Method for Controlling Skew on Linked Surfaces

    SciTech Connect

    BENZLEY,STEVEN E.; KERR,ROBERT A.; MITCHELL,SCOTT A.; WHITE,DAVID R.

    1999-09-27

    A new method for lessening skew in mapped meshes is presented. This new method involves progressive subdivision of a surface into loops consisting of four sides. Using these loops, constraints can then be set on the curves of the surface, which will propagate interval assignments across the surface, allowing a mesh with a better skew metric to be generated.

  20. Analysis of carbon dioxide concentration skewness at a rural site.

    PubMed

    Pérez, Isidro A; Sánchez, M Luisa; García, M Ángeles; Ozores, Marta; Pardo, Nuria

    2014-04-01

    This paper provides evidence that symmetry of CO2 concentration distribution may indicate sources or dispersive processes. Skewness was calculated by different procedures with CO2 measured at a rural site using a Picarro G1301 analyser over a two-year period. The usual skewness coefficient was considered together with fourteen robust estimators. A noticeable contrast was obtained between day and night, and skewness decreased linearly with the logarithm of the height. One coefficient was selected from its satisfactory relationship with the median concentration in daily evolution. Three analyses based on the kernel smoothing method were conducted with this coefficient to investigate its response to yearly and daily evolutions, wind direction, and wind speed. Left-skewed distributions were linked to thermal turbulence during midday, especially in spring-summer, or with high wind speeds. Almost symmetric distributions were associated with sources, such as the Valladolid City plume reinforced with spring emissions and the lack of emissions in summer in the remaining directions. Finally, right-skewed distributions were related to low wind speeds and stable stratification at night, furthered by strong emissions in spring. Skewness intervals were proposed and their average median concentrations were calculated such that the relationship between skewness and concentration depends on the analysis performed. Since some skewness coefficients may also be negative, they provide better information about sources or dispersive processes than concentration. PMID:24463252

  1. Learning a Novel Pattern through Balanced and Skewed Input

    ERIC Educational Resources Information Center

    McDonough, Kim; Trofimovich, Pavel

    2013-01-01

    This study compared the effectiveness of balanced and skewed input at facilitating the acquisition of the transitive construction in Esperanto, characterized by the accusative suffix "-n" and variable word order (SVO, OVS). Thai university students (N = 98) listened to 24 sentences under skewed (one noun with high token frequency) or…

  2. Mean, Median, and Skew: Correcting a Textbook Rule

    ERIC Educational Resources Information Center

    von Hippel, Paul T.

    2005-01-01

    Many textbooks teach a rule of thumb stating that the mean is right of the median under right skew, and left of the median under left skew. This rule fails with surprising frequency. It can fail in multimodal distributions, or in distributions where one tail is long but the other is heavy. Most commonly, though, the rule fails in discrete…

  3. Investigating the Investigative Task: Testing for Skewness--An Investigation of Different Test Statistics and Their Power to Detect Skewness

    ERIC Educational Resources Information Center

    Tabor, Josh

    2010-01-01

    On the 2009 AP[c] Statistics Exam, students were asked to create a statistic to measure skewness in a distribution. This paper explores several of the most popular student responses and evaluates which statistic performs best when sampling from various skewed populations. (Contains 8 figures, 3 tables, and 4 footnotes.)

  4. Interaction of a skewed Rankine vortex pair

    NASA Astrophysics Data System (ADS)

    Jayavel, S.; Patil, Pratish P.; Tiwari, Shaligram

    2008-08-01

    An analytical investigation is carried out to study the kinematics of a fluid particle in an interacting field of a skewed pair of fixed Rankine vortices. A general formulation governing the kinematics of a fluid particle has been presented based on the superposition of the velocity field due to each vortex in the pair. The kinematics of a Lagrangian fluid particle is found to be governed by a nonlinear dynamical system. The fixed or stationary points of the dynamical system have been identified analytically and their existence is confirmed by the nature of particle paths in the neighborhood of fixed points. The nature of the particle path and velocity signal is reported for general as well as special configurations of the vortex pair in the presence and absence of an external uniform flow. As a specific application of the proposed problem, superimposition of the translational velocity on a semi-infinite field of longitudinal vortices generated by vortex generators mounted on fin plates of heat exchangers has also been studied.

  5. Female reproductive synchrony predicts skewed paternity across primates

    PubMed Central

    Nunn, Charles L.; Schülke, Oliver

    2008-01-01

    Recent studies have uncovered remarkable variation in paternity within primate groups. To date, however, we lack a general understanding of the factors that drive variation in paternity skew among primate groups and across species. Our study focused on hypotheses from reproductive skew theory involving limited control and the use of paternity “concessions” by investigating how paternity covaries with the number of males, female estrous synchrony, and rates of extragroup paternity. In multivariate and phylogenetically controlled analyses of data from 27 studies on 19 species, we found strong support for a limited control skew model, with reproductive skew within groups declining as female reproductive synchrony and the number of males per group increase. Of these 2 variables, female reproductive synchrony explained more of the variation in paternity distributions. To test whether dominant males provide incentives to subordinates to resist matings by extragroup males, that is, whether dominants make concessions of paternity, we derived a novel prediction that skew is lower within groups when threat from outside the group exists. This prediction was not supported as a primary factor underlying patterns of reproductive skew among primate species. However, our approach revealed that if concessions occur in primates, they are most likely when female synchrony is low, as these conditions provide alpha male control of paternity that is assumed by concessions models. Collectively, our analyses demonstrate that aspects of male reproductive competition are the primary drivers of reproductive skew in primates. PMID:19018288

  6. Utility functions predict variance and skewness risk preferences in monkeys

    PubMed Central

    Genest, Wilfried; Stauffer, William R.; Schultz, Wolfram

    2016-01-01

    Utility is the fundamental variable thought to underlie economic choices. In particular, utility functions are believed to reflect preferences toward risk, a key decision variable in many real-life situations. To assess the validity of utility representations, it is therefore important to examine risk preferences. In turn, this approach requires formal definitions of risk. A standard approach is to focus on the variance of reward distributions (variance-risk). In this study, we also examined a form of risk related to the skewness of reward distributions (skewness-risk). Thus, we tested the extent to which empirically derived utility functions predicted preferences for variance-risk and skewness-risk in macaques. The expected utilities calculated for various symmetrical and skewed gambles served to define formally the direction of stochastic dominance between gambles. In direct choices, the animals’ preferences followed both second-order (variance) and third-order (skewness) stochastic dominance. Specifically, for gambles with different variance but identical expected values (EVs), the monkeys preferred high-variance gambles at low EVs and low-variance gambles at high EVs; in gambles with different skewness but identical EVs and variances, the animals preferred positively over symmetrical and negatively skewed gambles in a strongly transitive fashion. Thus, the utility functions predicted the animals’ preferences for variance-risk and skewness-risk. Using these well-defined forms of risk, this study shows that monkeys’ choices conform to the internal reward valuations suggested by their utility functions. This result implies a representation of utility in monkeys that accounts for both variance-risk and skewness-risk preferences. PMID:27402743

  7. Bayesian QTL mapping using skewed Student-t distributions

    PubMed Central

    von Rohr, Peter; Hoeschele, Ina

    2002-01-01

    In most QTL mapping studies, phenotypes are assumed to follow normal distributions. Deviations from this assumption may lead to detection of false positive QTL. To improve the robustness of Bayesian QTL mapping methods, the normal distribution for residuals is replaced with a skewed Student-t distribution. The latter distribution is able to account for both heavy tails and skewness, and both components are each controlled by a single parameter. The Bayesian QTL mapping method using a skewed Student-t distribution is evaluated with simulated data sets under five different scenarios of residual error distributions and QTL effects. PMID:11929622

  8. PRINCIPLE OF SKEW QUADRUPOLE MODULATION TO MEASURE BETATRON COUPLING.

    SciTech Connect

    LUO.Y.PILAT,F.ROSER,T.ET AL.

    2004-07-05

    The measurement of the residual betatron coupling via skew quadrupole modulation is a new diagnostics technique that has been developed and tested at the Relativistic Heavy Ion Collider (RHIC) as a very promising method for the linear decoupling on the ramp. By modulating the strengths of different skew quadrupole families the two eigentunes are precisely measured with the phase lock loop system. The projections of the residual coupling coefficient onto the skew quadrupole coupling modulation directions are determined. The residual linear coupling could be corrected according to the measurement. An analytical solution for skew quadrupole modulation based on Hamiltonian perturbation approximation is given, and simulation code using smooth accelerator model is also developed. Some issues concerning the practical applications of this technique are discussed.

  9. 2. Skew Span on left to Span 3 on right ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Skew Span on left to Span 3 on right from north bank-up river. - Monongahela Connecting Railroad Company, Hot Metal Bridge, Spanning Monongahela River at mile post 3.1, Pittsburgh, Allegheny County, PA

  10. 4. From Skew Span to portal on span 1 looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. From Skew Span to portal on span 1 looking up grade toward the south end. - Monongahela Connecting Railroad Company, Hot Metal Bridge, Spanning Monongahela River at mile post 3.1, Pittsburgh, Allegheny County, PA

  11. 3. Span 4 on right to Skew Span on leftfrom ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Span 4 on right to Skew Span on left-from south bank-up river. - Monongahela Connecting Railroad Company, Hot Metal Bridge, Spanning Monongahela River at mile post 3.1, Pittsburgh, Allegheny County, PA

  12. Systems of Differential Equations with Skew-Symmetric, Orthogonal Matrices

    ERIC Educational Resources Information Center

    Glaister, P.

    2008-01-01

    The solution of a system of linear, inhomogeneous differential equations is discussed. The particular class considered is where the coefficient matrix is skew-symmetric and orthogonal, and where the forcing terms are sinusoidal. More general matrices are also considered.

  13. Bicriterion seriation methods for skew-symmetric matrices.

    PubMed

    Brusco, Michael J; Stahl, Stephanie

    2005-11-01

    The decomposition of an asymmetric proximity matrix into its symmetric and skew-symmetric components is a well-known principle in combinatorial data analysis. The seriation of the skew-symmetric component can emphasize information corresponding to the sign or absolute magnitude of the matrix elements, and the choice of objective criterion can have a profound impact on the ordering. In this research note, we propose a bicriterion approach for seriation of a skew-symmetric matrix incorporating both sign and magnitude information. Two numerical demonstrations reveal that the bicriterion procedure is an effective alternative to direct seriation of the skew-symmetric matrix, facilitating favourable trade-offs among sign and magnitude information. PMID:16293204

  14. 9. Skew Spanunderneath showing floor system for two tracks on ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Skew Span-underneath showing floor system for two tracks on Main Bridge, from abutment end toward Rocker Bent. - Monongahela Connecting Railroad Company, Main Bridge, Spanning Monongahela River at mile post 3.1, Pittsburgh, Allegheny County, PA

  15. Interior view of skewed Baltimore truss and curved deck of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior view of skewed Baltimore truss and curved deck of Bridge No. 1363, First B&O Crossing, looking west. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  16. LOOKING WEST, BETWEEN READING DEPOT BRIDGE AND SKEW ARCH BRIDGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOOKING WEST, BETWEEN READING DEPOT BRIDGE AND SKEW ARCH BRIDGE (HAER No. PA-116). - Philadelphia & Reading Railroad, Reading Depot Bridge, North Sixth Street at Woodward Street, Reading, Berks County, PA

  17. 2. Skewed view of E elevation of sugar mill looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Skewed view of E elevation of sugar mill looking NW. - Hacienda Azurarera Santa Elena, Sugar Mill Ruins, 1.44 miles North of PR Route 2 Bridge Over Rio De La Plata, Toa Baja, Toa Baja Municipio, PR

  18. 7. William E. Barrett, Photographer, 1974. SKEWED VIEW SHOWING CHEAT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. William E. Barrett, Photographer, 1974. SKEWED VIEW SHOWING CHEAT RIVER VALLEY, REMAINS OF 1887 PIER AND c. 1900 MASONRY ARCHES. - Baltimore & Ohio Railroad, Tray Run Viaduct, Spanning Tray Run, Rowlesburg, Preston County, WV

  19. Interior view of skewed Baltimore truss of Bridge No. 1363, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior view of skewed Baltimore truss of Bridge No. 1363, First B&O Crossing, looking west. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  20. Vortex Generation by a Pitched and Skewed Jet in Crossflow

    NASA Astrophysics Data System (ADS)

    Khan, Zia U.; Johnston, James P.

    1996-11-01

    A pitched and skewed jet introduced transversely through a wall into a crossflow produces a dominant streamwise vortex. The resulting circulation pattern sweeps freestream fluid towards the wall. This has important ramifications for both boundary layer separation control and film cooling applications. The governing parameters for a fixed crossflow velocity are the jet's pitch and skew angles, and the velocity ratio between the jet and the crossflow. Detailed flow visualization has characterized the flow and the effects of the parameters. The vortex contains jet fluid and entrained crossflow fluid, but the central core of the vortex consists primarily of jet boundary layer fluid. By incrementally increasing the skew angle from 0^o to 90^o, we see that the dominant vortex is an amplified version of one of the counter-rotating vortices observed in flows where the jet is injected normal to the wall. The dominant vortex is similar to that produced by a skewed solid vortex generator.

  1. Vibration of skewed cantilever plates and helicoidal shells

    NASA Technical Reports Server (NTRS)

    Beres, D. P.; Bailey, C. D.

    1975-01-01

    Theoretical vibration frequencies and mode shapes are obtained for skewed plates and helicoidal shells with a cantilever boundary. Using Hamilton's law of varying action, a power series solution is developed to obtain converged numerical results for the five lowest frequencies. Effects of geometrical variables such as aspect ratio, sweep angle and shell radius to thickness ratio are investigated. Accuracy of the solution method is substantiated by comparison with existing skewed plate spherical cap, and conical shell results.

  2. Flow in Rotating Serpentine Coolant Passages With Skewed Trip Strips

    NASA Technical Reports Server (NTRS)

    Tse, David G.N.; Steuber, Gary

    1996-01-01

    Laser velocimetry was utilized to map the velocity field in serpentine turbine blade cooling passages with skewed trip strips. The measurements were obtained at Reynolds and Rotation numbers of 25,000 and 0.24 to assess the influence of trips, passage curvature and Coriolis force on the flow field. The interaction of the secondary flows induced by skewed trips with the passage rotation produces a swirling vortex and a corner recirculation zone. With trips skewed at +45 deg, the secondary flows remain unaltered as the cross-flow proceeds from the passage to the turn. However, the flow characteristics at these locations differ when trips are skewed at -45 deg. Changes in the flow structure are expected to augment heat transfer, in agreement with the heat transfer measurements of Johnson, et al. The present results show that trips are skewed at -45 deg in the outward flow passage and trips are skewed at +45 deg in the inward flow passage maximize heat transfer. Details of the present measurements were related to the heat transfer measurements of Johnson, et al. to relate fluid flow and heat transfer measurements.

  3. Reproductive skew and the threat of eviction: a new perspective

    PubMed Central

    Johnstone, R. A.; Cant, M. A.

    1999-01-01

    Most recent models of the partitioning of reproduction attempt to explain patterns of skew on the assumption that dominant individuals have complete control over breeding opportunities within the group, but may nevertheless concede a share of direct reproduction to subordinates as an incentive to remain peacefully in the association. Although these models may be applicable to some animal societies, we argue that they fail to provide a comprehensive theory of skew. Instead, we suggest that subordinates may often be able to claim unsanctioned reproduction for themselves, but will be forced to exercise a degree of reproductive restraint lest they incite ejection by the dominant. Reproductive skew, in other words, may reflect the threat of ejection (inducing subordinate restraint) rather than the threat of subordinate departure (inducing reproductive concessions by dominants). We present a simple ESS model of reproductive skew under these circumstances, which demonstrates that a shift in emphasis from reproductive concessions by dominants to reproductive restraint on the part of subordinates, radically alters the predictions of skew models. High group productivity, high relatedness and (when group members are related) strong ecological constraints are all expected to lead to reduced skew (the opposite conclusions to those of previous, concession-based analyses). The reason is that these factors reduce the benefits (or increase the costs) of ejection to the dominant, who therefore does best to tolerate more subordinate reproduction.

  4. Extension of EMA to address regional skew and low outliers

    USGS Publications Warehouse

    Griffis, V.W.; Stedinger, J.R.; Cohn, T.A.

    2003-01-01

    The recently developed expected moments algorithm [EMA] (Cohn et al. 1997) does as well as MLEs at estimating LP3 flood quantiles using systematic and historical information. Needed extensions include use of a regional skewness estimator and its precision to be consistent with Bulletin 17B and to make use of such hydrologic information. Another issue addressed by Bulletin 17B is the treatment of low outliers. A Monte Carlo study illustrates the performance of an extended EMA estimator compared to estimators that employ the complete data set with and without use of regional skew, conditional probability adjustment from Bulletin 17B, and an estimator that uses probability plot regression to compute substitute values for low outliers. Estimators that use a regional skew all do better than estimators that fail to use an informative regional skewness estimator. For LP3 data, the low outlier rejection procedure results in no loss of overall accuracy, and the differences between the MSEs of the estimators that used an informative regional skew were generally negligible in the skew range of real interest.

  5. Sample Skewness as a Statistical Measurement of Neuronal Tuning Sharpness

    PubMed Central

    Samonds, Jason M.; Potetz, Brian R.; Lee, Tai Sing

    2014-01-01

    We propose using the statistical measurement of the sample skewness of the distribution of mean firing rates of a tuning curve to quantify sharpness of tuning. For some features, like binocular disparity, tuning curves are best described by relatively complex and sometimes diverse functions, making it difficult to quantify sharpness with a single function and parameter. Skewness provides a robust nonparametric measure of tuning curve sharpness that is invariant with respect to the mean and variance of the tuning curve and is straightforward to apply to a wide range of tuning, including simple orientation tuning curves and complex object tuning curves that often cannot even be described parametrically. Because skewness does not depend on a specific model or function of tuning, it is especially appealing to cases of sharpening where recurrent interactions among neurons produce sharper tuning curves that deviate in a complex manner from the feedforward function of tuning. Since tuning curves for all neurons are not typically well described by a single parametric function, this model independence additionally allows skewness to be applied to all recorded neurons, maximizing the statistical power of a set of data. We also compare skewness with other nonparametric measures of tuning curve sharpness and selectivity. Compared to these other nonparametric measures tested, skewness is best used for capturing the sharpness of multimodal tuning curves defined by narrow peaks (maximum) and broad valleys (minima). Finally, we provide a more formal definition of sharpness using a shape-based information gain measure and derive and show that skewness is correlated with this definition. PMID:24555451

  6. Rényi entropy and complexity measure for skew-gaussian distributions and related families

    NASA Astrophysics Data System (ADS)

    Contreras-Reyes, Javier E.

    2015-09-01

    In this paper, we provide the Rényi entropy and complexity measure for a novel, flexible class of skew-gaussian distributions and their related families, as a characteristic form of the skew-gaussian Shannon entropy. We give closed expressions considering a more general class of closed skew-gaussian distributions and the weighted moments estimation method. In addition, closed expressions of Rényi entropy are presented for extended skew-gaussian and truncated skew-gaussian distributions. Finally, additional inequalities for skew-gaussian and extended skew-gaussian Rényi and Shannon entropies are reported.

  7. Latitudinal skewness in global EQ distributions

    NASA Astrophysics Data System (ADS)

    Sasorova, E.; Levin, B.

    2009-04-01

    The results of statistical analysis of worldwide seismic catalogs (ISC and NEIC), which was carried out in frame of two projects are presented. In both cases we extracted the evens occurred in the Pacific region from 1964 with Mb>=4.0. The aftershocks were canceled from the list. All events were divided into following magnitude ranges (MR): 4<=Mb<4.5; 4.5<=Mb<5; 5<=Mb<5.5; 5.5<=Mb<6.0; 6<=Mb. Further analysis was performed separately for each MR. In frame of the first project [Levin, Sasorova, 2009] the whole Pacific region was divided in 18 latitudinal intervals (size of every interval was 10 deg). The number of events in each latitudinal interval was normalized two times. The first one number of events was divided on common number of events in given MR. It was calculated relative number of events in each latitudinal interval for given MR. Then normalization was produced with respect to the length of lithosphere plate boundaries situated in given latitude zone. The approach gives the characteristic of seismicity for lithosphere plate boundary, i.e. seismic event number which was generated at unit of length of plate boundary. An analysis of the Pacific earthquake latitude distribution showed that the empirical distribution is described by a bimodal function with two maxima in middle latitudes (40-50 deg N and 20-30 deg S), local minimum near equator (10-20 deg N), and zero values in polar zones. Thus the bimodal latitudinal EQ distribution shows clear expressed skewness (in direction to the Northern Hemisphere). The stability of distributions from the observation interval size was demonstrated on the data independence analysis for several ten-year intervals. Then it was carried out the analysis about statistically valid regularity of the EQ distribution over depth and over latitudinal belts for different magnitude ranges (MR). It was shown, that for the high latitudes up to 90% of the EQ sources are located on the depth H<=20 km. The part of EQ with 20

  8. Quantum Fisher and skew information for Unruh accelerated Dirac qubit

    NASA Astrophysics Data System (ADS)

    Banerjee, Subhashish; Alok, Ashutosh Kumar; Omkar, S.

    2016-08-01

    We develop a Bloch vector representation of the Unruh channel for a Dirac field mode. This is used to provide a unified, analytical treatment of quantum Fisher and skew information for a qubit subjected to the Unruh channel, both in its pure form as well as in the presence of experimentally relevant external noise channels. The time evolution of Fisher and skew information is studied along with the impact of external environment parameters such as temperature and squeezing. The external noises are modelled by both purely dephasing phase damping and the squeezed generalised amplitude damping channels. An interesting interplay between the external reservoir temperature and squeezing on the Fisher and skew information is observed, in particular, for the action of the squeezed generalised amplitude damping channel. It is seen that for some regimes, squeezing can enhance the quantum information against the deteriorating influence of the ambient environment. Similar features are also observed for the analogous study of skew information, highlighting a similar origin of the Fisher and skew information.

  9. OPERATIONAL MEASUREMENT OF COUPLING BY SKEW QUADRUPOLE MODULATION.

    SciTech Connect

    LUO.Y.CAMERON,P.LEE,R.ET AL.

    2004-07-05

    The measurement and correction of the residual betatron coupling via skew quadrupole modulation is a new diagnostics technique that has been developed and tested at the Relativistic Heavy Ion Collider (RHIC) as a very promising method for the linear decoupling on the ramp. By modulating the strengths of the skew quadrupole families the two eigentune modulations are precisely measured with a high resolution phase lock loop system. The projections of the residual coupling coefficient onto the skew quadrupole coupling modulation direction are determined. The residual linear coupling could be corrected according the measurement. We report the results from the dedicated beam studies carried on at RHIC injection, store and on the ramp. A capability of measuring coupling on the ramp opens possibility of continuous coupling corrections during acceleration.

  10. Determining collective barrier operation skew in a parallel computer

    SciTech Connect

    Faraj, Daniel A.

    2015-11-24

    Determining collective barrier operation skew in a parallel computer that includes a number of compute nodes organized into an operational group includes: for each of the nodes until each node has been selected as a delayed node: selecting one of the nodes as a delayed node; entering, by each node other than the delayed node, a collective barrier operation; entering, after a delay by the delayed node, the collective barrier operation; receiving an exit signal from a root of the collective barrier operation; and measuring, for the delayed node, a barrier completion time. The barrier operation skew is calculated by: identifying, from the compute nodes' barrier completion times, a maximum barrier completion time and a minimum barrier completion time and calculating the barrier operation skew as the difference of the maximum and the minimum barrier completion time.

  11. Uniqueness: skews bit occurrence frequencies in randomly generated fingerprint libraries.

    PubMed

    Chen, Nelson G

    2016-08-01

    Requiring that randomly generated chemical fingerprint libraries have unique fingerprints such that no two fingerprints are identical causes a systematic skew in bit occurrence frequencies, the proportion at which specified bits are set. Observed frequencies (O) at which each bit is set within the resulting libraries systematically differ from frequencies at which bits are set at fingerprint generation (E). Observed frequencies systematically skew toward 0.5, with the effect being more pronounced as library size approaches the compound space, which is the total number of unique possible fingerprints given the number of bit positions each fingerprint contains. The effect is quantified for varying library sizes as a fraction of the overall compound space, and for changes in the specified frequency E. The cause and implications for this systematic skew are subsequently discussed. When generating random libraries of chemical fingerprints, the imposition of a uniqueness requirement should either be avoided or taken into account. PMID:27230477

  12. A Longitudinal Twin Study of Skewed X Chromosome-Inactivation

    PubMed Central

    Wong, Chloe Chung Yi; Caspi, Avshalom; Williams, Benjamin; Houts, Renate; Craig, Ian W.; Mill, Jonathan

    2011-01-01

    X-chromosome inactivation (XCI) is a pivotal epigenetic mechanism involved in the dosage compensation of X-linked genes between males and females. In any given cell, the process of XCI in early female development is thought to be random across alleles and clonally maintained once established. Recent studies, however, suggest that XCI might not always be random and that skewed inactivation may become more prevalent with age. The factors influencing such XCI skewing and its changes over time are largely unknown. To elucidate the influence of stochastic, heritable and environmental factors in longitudinal changes in XCI, we examined X inactivation profiles in a sample of monozygotic (MZ) (n = 23) and dizygotic (DZ) (n = 22) female twin-pairs at ages 5 and 10 years. Compared to MZ twins who were highly concordant for allelic XCI ratios, DZ twins showed much lower levels of concordance. Whilst XCI patterns were moderately stable between ages 5 and 10 years, there was some drift over time with an increased prevalence of more extreme XCI skewing at age 10. To our knowledge, this study represents the earliest longitudinal assessment of skewed XCI patterns, and suggests that skewed XCI may already be established in early childhood. Our data also suggest a link between MZ twinning and the establishment of allelic XCI ratios, and demonstrate that acquired skewing in XCI after establishment is primarily mediated by stochastic mechanisms. These data have implications for our understanding about sex differences in complex disease, and the potential causes of phenotypic discordance between MZ female twins. PMID:21445353

  13. Bayesian partial linear model for skewed longitudinal data.

    PubMed

    Tang, Yuanyuan; Sinha, Debajyoti; Pati, Debdeep; Lipsitz, Stuart; Lipshultz, Steven

    2015-07-01

    Unlike majority of current statistical models and methods focusing on mean response for highly skewed longitudinal data, we present a novel model for such data accommodating a partially linear median regression function, a skewed error distribution and within subject association structures. We provide theoretical justifications for our methods including asymptotic properties of the posterior and associated semiparametric Bayesian estimators. We also provide simulation studies to investigate the finite sample properties of our methods. Several advantages of our method compared with existing methods are demonstrated via analysis of a cardiotoxicity study of children of HIV-infected mothers. PMID:25792623

  14. Power and Skew Aware Point Diffusion Clock Network

    NASA Astrophysics Data System (ADS)

    Jung, Gunok; Kim, Chunghee; Chae, Kyoungkuk; Park, Giho; Park, Sung Bae

    This letter presents point diffusion clock network (PDCN) with local clock tree synthesis (CTS) scheme. The clock network is implemented with ten times wider metal line space than typical mesh networks for low power and utilized to nine times smaller area CTS execution for minimized clock skew amount. The measurement results show that skew amount of PDCN with local CTS is reduced to 36% and latency is shrunk to 45% of the amount in a 4.81mm2 CortexA-8 core with 65nm Samsung process.

  15. Skewness of steady-state current fluctuations in nonequilibrium systems

    NASA Astrophysics Data System (ADS)

    Belousov, Roman; Cohen, E. G. D.; Wong, Chun-Shang; Goree, John A.; Feng, Yan

    2016-04-01

    A skewness of the probability for instantaneous current fluctuations, in a nonequilibrium steady state, is observed experimentally in a dusty plasma. This skewness is attributed to the spatial asymmetry, which is imminent to the nonequilibrium systems due to the external hydrodynamic gradient. Using the modern framework of the large deviation theory, we extend the Onsager-Machlup ansatz for equilibrium fluctuations to systems with a preferred spatial direction, and provide a modulated Gaussian probability distribution, which is tested by simulations. This probability distribution is also of potential interest for other statistical disciplines. Connections with the principles of statistical mechanics, due to Boltzmann and Gibbs, are discussed as well.

  16. Skew flap for staged below-knee amputation in sepsis.

    PubMed

    Matthews, Christopher O; Williams, Ian M; Lewis, Peter; McLain, A David; Twine, Christopher P

    2016-04-01

    Skew flap amputation was first described in the 1980s but was never as popular as the long posterior flap amputation. This report describes a staged below-knee amputation in sepsis, with pus throughout the leg and a lack of skin coverage. One benefit of skew flaps never previously published is the fact that the suture line is not directly over the tibia. Therefore, an open wound or incomplete skin coverage is not as important as in long posterior flaps where it often leads to bone exposure and revision amputation. These benefits were utilized in this case leading to stump healing. PMID:26002782

  17. On Optimal Backward Perturbation Analysis for the Linear System with Skew Circulant Coefficient Matrix

    PubMed Central

    Jiang, Zhaolin; Shen, Nuo; Zhou, Jianwei

    2013-01-01

    We first give the style spectral decomposition of a special skew circulant matrix C and then get the style decomposition of arbitrary skew circulant matrix by making use of the Kronecker products between the elements of first row in skew circulant and the special skew circulant C. Besides that, we obtain the singular value of skew circulant matrix as well. Finally, we deal with the optimal backward perturbation analysis for the linear system with skew circulant coefficient matrix on the base of its style spectral decomposition. PMID:24369488

  18. 4. North portal of Skew Span looking south and leading ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. North portal of Skew Span looking south and leading to Span 1 Main Bridge on the left and Span 1 Hot Metal Bridge on the right. - Monongahela Connecting Railroad Company, Main Bridge, Spanning Monongahela River at mile post 3.1, Pittsburgh, Allegheny County, PA

  19. Making Skew-Resistant Fabrics For Composite Layups

    NASA Technical Reports Server (NTRS)

    Farley, Gary L.

    1994-01-01

    Fabrics used in curved composite-material structures prevented from skewing during composite layup by weaving them in modified process in which warp and fill yarns bonded together at their points of contact. (Bonding concept may prove similarly beneficial for braided and knitted fabrics.) In modified weaving process, adhesives prevent excessive shifting of warp and fill yarns with respect to each other.

  20. Sum uncertainty relations based on Wigner-Yanase skew information

    NASA Astrophysics Data System (ADS)

    Chen, Bin; Fei, Shao-Ming; Long, Gui-Lu

    2016-03-01

    We study sum uncertainty relations for arbitrary finite N quantum mechanical observables. Some uncertainty inequalities are presented by using skew information introduced by Wigner and Yanase. These uncertainty inequalities are nontrivial as long as the observables are mutually noncommutative. The relations among these new and existing uncertainty inequalities have been investigated. Detailed examples are presented.

  1. Thermocline Feedback Influence on Indian Ocean Dipole Skewness

    NASA Astrophysics Data System (ADS)

    Ng, B.; Cai, W.; Walsh, K. J.

    2014-12-01

    A positive Indian Ocean Dipole (IOD) tends to have stronger cold sea surface temperature anomalies (SSTAs) over the eastern Indian Ocean with greater impacts than warm SSTAs that occur during its negative phase. These impacts from positive IODs range from drought over Australia and Indonesia, to flooding over East Africa and India. Two feedbacks have been suggested as the cause of positive IOD skewness, a positive Bjerknes feedback and a negative SST-cloud-radiation (SCR) feedback, but their relative importance is debated. Using models from phase 5 of the Coupled Model Intercomparison Project (CMIP5) and inter-model statistics, we show that the most important process for IOD skewness is an asymmetry in the thermocline feedback, whereby SSTAs respond to thermocline depth anomalies more strongly during the positive phase than negative phase. This asymmetric thermocline feedback drives IOD skewness despite positive IODs receiving greater damping from the SCR feedback. In response to global warming, although the thermocline feedback strengthens, its asymmetry between positive and negative IODs weakens. This behaviour change explains the reduction in IOD skewness that many models display under global warming.

  2. 8. Detail, skewed portal bracing at west portal, also showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Detail, skewed portal bracing at west portal, also showing boxed endposts, latticed upper transverse and diagonal sway bracing, laced vertical members, view to northeast, 210mm lens. - Southern Pacific Railroad Shasta Route, Bridge No. 301.85, Milepost 301.85, Pollard Flat, Shasta County, CA

  3. Sum uncertainty relations based on Wigner-Yanase skew information

    NASA Astrophysics Data System (ADS)

    Chen, Bin; Fei, Shao-Ming; Long, Gui-Lu

    2016-06-01

    We study sum uncertainty relations for arbitrary finite N quantum mechanical observables. Some uncertainty inequalities are presented by using skew information introduced by Wigner and Yanase. These uncertainty inequalities are nontrivial as long as the observables are mutually noncommutative. The relations among these new and existing uncertainty inequalities have been investigated. Detailed examples are presented.

  4. 3. VIEW SOUTHEAST VIEW OF EAST PORTAL SHOWING SKEW AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW SOUTHEAST- VIEW OF EAST PORTAL SHOWING SKEW AND PORTAL BRACING. - National Docks Branch Bridge N.D.2F, Spans former Central Railroad of New Jersey , west of New Jersey Turnpike, north of Communipaw Avenue near Johnson Avenue, Jersey City, Hudson County, NJ

  5. Arc voltage distribution skewness as an indicator of electrode gap during vacuum arc remelting

    DOEpatents

    Williamson, R.L.; Zanner, F.J.; Grose, S.M.

    1998-01-13

    The electrode gap of a VAR is monitored by determining the skewness of a distribution of gap voltage measurements. A decrease in skewness indicates an increase in gap and may be used to control the gap. 4 figs.

  6. Arc voltage distribution skewness as an indicator of electrode gap during vacuum arc remelting

    DOEpatents

    Williamson, Rodney L.; Zanner, Frank J.; Grose, Stephen M.

    1998-01-01

    The electrode gap of a VAR is monitored by determining the skewness of a distribution of gap voltage measurements. A decrease in skewness indicates an increase in gap and may be used to control the gap.

  7. Correcting Quadrupole Roll in Magnetic Lenses with Skew Quadrupoles

    SciTech Connect

    Walstrom, Peter Lowell

    2014-11-10

    Quadrupole rolls (i.e. rotation around the magnet axis) are known to be a significant source of image blurring in magnetic quadrupole lenses. These rolls may be caused by errors in mechanical mounting of quadrupoles, by uneven radiation-induced demagnetization of permanent-magnet quadrupoles, etc. Here a four-quadrupole ×10 lens with so-called ”Russian” or A -B B-A symmetry is used as a model problem. Existing SLAC 1/2 in. bore high-gradient quadrupoles are used in the design. The dominant quadrupole roll effect is changes in the first-order part of the transfer map (the R matrix) from the object to the image plane (Note effects on the R matrix can be of first order in rotation angle for some R-matrix elements and second order in rotation angle for other elements, as shown below). It is possible to correct roll-induced image blur by mechanically adjusting the roll angle of one or more of the quadrupoles. Usually, rotation of one quadrupole is sufficient to correct most of the combined effect of rolls in all four quadrupoles. There are drawbacks to this approach, however, since mechanical roll correction requires multiple entries into experimental area to make the adjustments, which are made according to their effect on images. An alternative is to use a single electromagnetic skew quadrupole corrector placed either between two of the quadrupoles or after the fourth quadrupole (so-called “non-local” correction). The basic feasibility of skew quadrupole correction of quadrupole roll effects is demonstrated here. Rolls of the third lens quadrupole of up to about 1 milliradian can be corrected with a 15 cm long skew quadrupole with a gradient of up to 1 T/m. Since the effect of rolls of the remaining three lens quadrupoles are lower, a weaker skew quadrupole can be used to correct them. Non-local correction of quadrupole roll effects by skew quadrupoles is shown to be about one-half as effective as local correction (i.e. rotating individual quadrupoles to zero

  8. Skew Divergence-Based Fuzzy Segmentation of Rock Samples

    NASA Astrophysics Data System (ADS)

    Carvalho, Bruno M.; Garduño, Edgar; Santos, Iraçú O.

    2014-03-01

    Digital image segmentation is a process in which one assigns distinct labels to different objects in a digital image. The MOFS (Multi Object Fuzzy Segmentation) algorithm has been successfully applied to the segmentation of images from several modalities. However, the traditional MOFS algorithm fails when applied to images whose composing objects are characterized by textures whose patterns cannot be successfully described by simple statistics computed over a very restricted area. Here, we present an extension of the MOFS algorithm that achieves the segmentation of textures by employing adaptive affinity functions that use the Skew Divergence as a measure of distance between two distributions. These affinity functions are called adaptive because their associated area (neighborhood) changes according to the characteristics of the texture being processed. We performed experiments on mosaic images composed by combining rock sample images which show the effectiveness of the adaptive skew divergence based fuzzy affinity functions.

  9. Skewed Brownian Fluctuations in Single-Molecule Magnetic Tweezers

    PubMed Central

    Burnham, Daniel R.; De Vlaminck, Iwijn; Henighan, Thomas; Dekker, Cees

    2014-01-01

    Measurements in magnetic tweezers rely upon precise determination of the position of a magnetic microsphere. Fluctuations in the position due to Brownian motion allows calculation of the applied force, enabling deduction of the force-extension response function for a single DNA molecule that is attached to the microsphere. The standard approach relies upon using the mean of position fluctuations, which is valid when the microsphere axial position fluctuations obey a normal distribution. However, here we demonstrate that nearby surfaces and the non-linear elasticity of DNA can skew the distribution. Through experiment and simulations, we show that such a skewing leads to inaccurate position measurements which significantly affect the extracted DNA extension and mechanical properties, leading to up to two-fold errors in measured DNA persistence length. We develop a simple, robust and easily implemented method to correct for such mismeasurements. PMID:25265383

  10. A stochastic daily weather generator for skewed data

    NASA Astrophysics Data System (ADS)

    Flecher, C.; Naveau, P.; Allard, D.; Brisson, N.

    2010-07-01

    To simulate multivariate daily time series (minimum and maximum temperatures, global radiation, wind speed, and precipitation intensity), we propose a weather state approach with a multivariate closed skew-normal generator, WACS-Gen, that is able to accurately reproduce the statistical properties of these five variables. Our weather generator construction takes advantage of two elements. We first extend the classical wet and dry days dichotomy used in most past weather generators to the definition of multiple weather states using clustering techniques. The transitions among weather states are modeled by a first-order Markov chain. Second, the vector of our five daily variables of interest is sampled, conditionally on these weather states, from a closed skew-normal distribution. This class of distribution allows us to handle nonsymmetric behaviors. Our method is applied to the 20 years of daily weather measurements from Colmar, France. This example illustrates the advantages of our approach, especially improving the simulation of radiation and wind distributions.

  11. SKEW QUADRUPOLES IN RHIC DIPOLE MAGNETS AT HIGH FIELDS.

    SciTech Connect

    JAIN, A.; GUPTA, P.; THOMPSON, P.; WANDERER, P.

    1995-06-11

    In the RHIC arc dipoles, the center of the cold mass lies above the center of the cryostat. At the maximum design field, the magnetic flux lines leak through the yoke to the asymmetrically located cryostat, which provides an additional return path. This introduces a systematic top-bottom asymmetry leading to a skew quadrupole term at high fields. A similar asymmetry is also created by any difference in weights of the upper and the lower yoke halves. Data from measurements of several RHIC dipoles are presented to study this effect. In the current production series of the RDIC dipoles, an attempt is made to compensate the effect of the cryostat by an asymmetry in the iron yoke. Seven dipoles with this type of yoke have been cold tested, and show a reduced saturation in the skew quadrupole term, as expected.

  12. Skew quadrupole in RHIC dipole magnets at high fields

    SciTech Connect

    Jain, A.; Gupta, P.; Thompson, P.; Wanderer, P.

    1995-07-01

    In the RHIC arc dipoles, the center of the cold mass lies above the center of the cryostat. At the maximum design field, the magnetic flux lines leak through the yoke to the asymmetrically located cryostat, which provides an additional return path. This introduces a systematic top-bottom asymmetry leading to a skew quadrupole term at high fields. A similar asymmetry is also created by any difference in weights of the upper and the lower yoke halves. Data from measurements of several RHIC dipoles are presented to study this effect. In the current production series of the RHIC dipoles, an attempt is made to compensate the effect of the cryostat by an asymmetry in the iron yoke. Seven dipoles with this type of yoke have been cold tested, and show a reduced saturation in the skew quadrupole term, as expected.

  13. Quantifying Correlations via the Wigner-Yanase-Dyson Skew Information

    NASA Astrophysics Data System (ADS)

    Fan, Yajing; Cao, Huaixin

    2016-09-01

    In this paper, based on a discussion about the Wigner-Yanase-Dyson (WYD) skew information, the measure F a, α ( ρ a b ) for correlations in terms of the WYD skew information is introduced and discussed. The following conclusions are obtained. For a classical-quantum state ρ a b , F a, α ( ρ a b )=0 if and only if ρ a b is a product state; F a, α ( ρ a b ) is locally unitary invariant and convex on the set of states with the fixed marginal ρ a ; F a, α ( ρ a b ) decreases under local random unitary operation on H b ; For a quantum-classical state ρ a b , F a, α ( ρ a b ) decreases under local operation on H b ; Lastly, F a, α ( ρ a b ) is computed for the pure states and the Bell-diagonal states, respectively.

  14. Stability and extensibility results for abstract skew-product semiflows

    NASA Astrophysics Data System (ADS)

    Novo, Sylvia; Obaya, Rafael; Sanz, Ana M.

    In this paper we present new stability and extensibility results for skew-product semiflows with a minimal base flow. In particular, we describe the structure of uniformly stable and uniformly asymptotically stable sets admitting backwards orbits and the structure of omega-limit sets. As an application, the occurrence of almost periodic and almost automorphic dynamics for monotone non-autonomous infinite delay functional differential equations is analyzed.

  15. Skew and twist resistant hydrodynamic rotary shaft seal

    DOEpatents

    Dietle, Lannie; Kalsi, Manmohan Singh

    1999-01-01

    A hydrodynamically lubricated squeeze packing type rotary shaft seal suitable for lubricant retention and environmental exclusion which incorporates one or more resilient protuberances which and cooperate with the gland walls to hold the seal straight in its installation groove in unpressurized and low pressure lubricant retention applications thereby preventing skew-induced wear caused by impingement of abrasive contaminants present in the environment, and which also serve as radial bearings to prevent tipping of the seal within its installation gland.

  16. Skew and twist resistant hydrodynamic rotary shaft seal

    DOEpatents

    Dietle, L.; Kalsi, M.S.

    1999-02-23

    A hydrodynamically lubricated squeeze packing type rotary shaft seal suitable for lubricant retention and environmental exclusion which incorporates one or more resilient protuberances which cooperate with the gland walls to hold the seal straight in its installation groove in unpressurized and low pressure lubricant retention applications thereby preventing skew-induced wear caused by impingement of abrasive contaminants present in the environment, and which also serve as radial bearings to prevent tipping of the seal within its installation gland. 14 figs.

  17. Incorporating Skew into RMS Surface Roughness Probability Distribution

    NASA Technical Reports Server (NTRS)

    Stahl, Mark T.; Stahl, H. Philip.

    2013-01-01

    The standard treatment of RMS surface roughness data is the application of a Gaussian probability distribution. This handling of surface roughness ignores the skew present in the surface and overestimates the most probable RMS of the surface, the mode. Using experimental data we confirm the Gaussian distribution overestimates the mode and application of an asymmetric distribution provides a better fit. Implementing the proposed asymmetric distribution into the optical manufacturing process would reduce the polishing time required to meet surface roughness specifications.

  18. MEASURING LOCAL GRADIENT AND SKEW QUADRUPOLE ERRORS IN RHIC IRS.

    SciTech Connect

    CARDONA,J.; PEGGS,S.; PILAT,R.; PTITSYN,V.

    2004-07-05

    The measurement of local linear errors at RHIC interaction regions using an ''action and phase'' analysis of difference orbits has already been presented. This paper evaluates the accuracy of this technique using difference orbits that were taken when known gradient errors and skew quadrupole errors were intentionally introduced. It also presents action and phase analysis of simulated orbits when controlled errors are intentionally placed in a RHIC simulation model.

  19. TWIN SKEWED TRUSS RAILROAD BRIDGES NEAR BRIDGE STREET AT THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    TWIN SKEWED TRUSS RAILROAD BRIDGES NEAR BRIDGE STREET AT THE WEST END OF THE PLANT. THIS VIEW PROBABLY LOOKING NORTHWEST. BRIDGES BUILT OVER ERIE CANAL (WHICH FLOWED RIGHT THROUGH THE MIDDLE OF THE PLANT) BY AMERICAN BRIDGE COMPANY IN 1902. SINCE THIS PHOTO WAS TAKEN, NEAR BRIDGE HAS BEEN DEMOLISHED; FAR BRIDGE IS STILL IN SERVICE. - Solvay Process Company, Between Willis & Milton Avenues, Solvay, Onondaga County, NY

  20. Mutual impedance of nonplanar-skew sinusoidal dipoles

    NASA Technical Reports Server (NTRS)

    Richmond, J. H.; Geary, N. H.

    1974-01-01

    The mutual impedance of nonplanar-skew sinusoidal dipoles is presented as a summation of several exponential integrals with complex arguments. Mathematical models are developed to show the near-zone field of the sinusoidal dipole. The mutual impedance of coupled dipoles is expressed as the sum of four monopole-mobopole impedances to simplify the analysis procedure. The subroutines for solving the parameters of the dipoles are discussed.

  1. Tide and skew surge independence: New insights for flood risk

    NASA Astrophysics Data System (ADS)

    Williams, Joanne; Horsburgh, Kevin J.; Williams, Jane A.; Proctor, Robert N. F.

    2016-06-01

    Storm surges are a significant hazard to coastal communities around the world, putting lives at risk and costing billions of dollars in damage. Understanding how storm surges and high tides interact is crucial for estimating extreme water levels so that we can protect coastal communities. We demonstrate that in a tidal regime the best measure of a storm surge is the skew surge, the difference between the observed and predicted high water within a tidal cycle. Based on tide gauge records spanning decades from the UK, U.S., Netherlands, and Ireland we show that the magnitude of high water exerts no influence on the size of the most extreme skew surges. This is the first systematic proof that any storm surge can occur on any tide, which is essential for understanding worst-case scenarios. The lack of surge generation dependency on water depth emphasizes the dominant natural variability of weather systems in an observation-based analysis. Weak seasonal relationships between skew surges and high waters were identified at a minority of locations where long-period changes to the tidal cycle interact with the storm season. Our results allow advances to be made in methods for estimating the joint probabilities of storm surges and tides.

  2. Analysis of dynamic instability for arbitrarily laminated skew plates

    NASA Astrophysics Data System (ADS)

    Wu, G. Y.; Shih, Y. S.

    2006-04-01

    The dynamic instability and nonlinear response of rectangular and skew laminated plates subjected to periodic in-plane load are studied. Based on von Karman plate theory, the large amplitude dynamic equations of thin laminated plates are derived by applying the approach of generalized double Fourier series. On the assumed mode shape, the governing equations are reduced to the Mathieu equation using Galerkin's method. The incremental harmonic balance (IHB) method is applied to solve the nonlinear temporal equation of motion, and the region of dynamic instability is determined in this work. Calculations are carried out for isotropic, angle-ply and arbitrarily laminated plates under two cases of boundary conditions. The principal region of dynamic instability associated with the effect of the stacking sequence of lamination and the skew angle of plate are also investigated and discussed. The results obtained indicated that the instability behavior of the system is determined by the several parameters, such as the boundary condition, number of the layers, stacking sequence, in-plane load, aspect ratio, amplitude and the skew angle of plate.

  3. Validation of an Acoustic Impedance Prediction Model for Skewed Resonators

    NASA Technical Reports Server (NTRS)

    Howerton, Brian M.; Parrott, Tony L.

    2009-01-01

    An impedance prediction model was validated experimentally to determine the composite impedance of a series of high-aspect ratio slot resonators incorporating channel skew and sharp bends. Such structures are useful for packaging acoustic liners into constrained spaces for turbofan noise control applications. A formulation of the Zwikker-Kosten Transmission Line (ZKTL) model, incorporating the Richards correction for rectangular channels, is used to calculate the composite normalized impedance of a series of six multi-slot resonator arrays with constant channel length. Experimentally, acoustic data was acquired in the NASA Langley Normal Incidence Tube over the frequency range of 500 to 3500 Hz at 120 and 140 dB OASPL. Normalized impedance was reduced using the Two-Microphone Method for the various combinations of channel skew and sharp 90o and 180o bends. Results show that the presence of skew and/or sharp bends does not significantly alter the impedance of a slot resonator as compared to a straight resonator of the same total channel length. ZKTL predicts the impedance of such resonators very well over the frequency range of interest. The model can be used to design arrays of slot resonators that can be packaged into complex geometries heretofore unsuitable for effective acoustic treatment.

  4. Genomic comparisons between paired bacterial strains with strong and weak GC skews.

    PubMed

    Song, Tie-Jun; Wang, Yue; Shen, Jian-Gen; Pan, Jian-Ping; Huang, Jun

    2014-02-01

    A majority of known eubacterial genomes are characteristic of GC skew, i.e., the leading strand has exceeding number of G over C. The cause of this compositional bias is still not very clear. In this study, we chose five pairs of genomes from distantly related bacterial genera, i.e., Buchnera, Haemophilus, Mycoplasma, Mycobacterium, and Synechococcus, each containing one with strong GC skew and the other with weak GC skew. Through comparison of the orthologous genes in these genera, we found that neither chromosomal rearrangement nor CDS skew has direct relationship with GC skew. PMID:23457112

  5. Metric-Adjusted Skew Information: Convexity and Restricted Forms of Superadditivity

    NASA Astrophysics Data System (ADS)

    Cai, Liang; Hansen, Frank

    2010-07-01

    We give a truly elementary proof of the convexity of metric-adjusted skew information following an idea of Effros. We extend earlier results of weak forms of superadditivity to general metric-adjusted skew information. Recently, Luo and Zhang introduced the notion of semi-quantum states on a bipartite system and proved superadditivity of the Wigner-Yanase-Dyson skew informations for such states. We extend this result to the general metric-adjusted skew information. We finally show that a recently introduced extension to parameter values 1 < p ≤ 2 of the WYD-information is a special case of (unbounded) metric-adjusted skew information.

  6. Secondary anisotropies in CMB, skew-spectra and Minkowski Functionals

    NASA Astrophysics Data System (ADS)

    Munshi, Dipak; Coles, Peter; Heavens, Alan

    2013-01-01

    Secondary contributions to the anisotropy of the cosmic microwave background (CMB), such as the integrated Sachs-Wolfe (ISW) effect, the thermal Sunyaev-Zel'dovich (tSZ) effect, and the effect of gravitational lensing, have distinctive non-Gaussian signatures, and full descriptions therefore require information beyond that contained in their power spectra. The Minkowski Functionals (MF) are well-known as tools for quantifying any departure from Gaussianity and are affected by noise and other sources of confusion in a different way from the usual methods based on higher-order moments or polyspectra, thus providing complementary tools for CMB analysis and cross-validation of results. In this paper we use the recently introduced skew-spectra associated with the MFs to probe the topology of CMB maps to probe the secondary non-Gaussianity as a function of beam smoothing in order to separate various contributions. We devise estimators for these spectra in the presence of realistic observational masks and present expressions for their covariance as a function of instrumental noise. Specific results are derived for the mixed ISW-lensing and tSZ-lensing bispectra as well as contamination due to point sources for noise levels that correspond to the Planck (143 GHz channel) and Experimental Probe of Inflationary Cosmology (EPIC; 150 GHz channel) experiments. The cumulative signal-to-noise ratio (S/N) for one-point generalized skewness parameters can reach an order of O(10) for Planck and two orders of magnitude higher forEPIC, i.e. O(10^3). We also find that these three skew-spectra are correlated, having correlation coefficients r ˜ 0.5-1.0; higher l modes are more strongly correlated. Although the values of S/N increase with decreasing noise, the triplets of skew-spectra that determine the MFs become more correlated; the S/N of lensing-induced skew-spectra are smaller compared to that of a frequency-cleaned tSZ map.

  7. Effect of Resonator Axis Skew on Normal Incidence Impedance

    NASA Technical Reports Server (NTRS)

    Parrott, Tony L.; Jones, Michael G.; Homeijer, Brian

    2003-01-01

    High by-pass turbofan engines have fewer fan blades and lower rotation speeds than their predecessors. Consequently, the noise suppression at the low frequency end of the noise spectra has become an increasing concern. This has led to a renewed emphasis on improving noise suppression efficiency of passive, duct liner treatments at the lower frequencies. For a variety of reasons, passive liners are comprised of locally-reacting, resonant absorbers. One reason for this design choice is to satisfy operational and economic requirements. The simplest liner design consists of a single layer of honeycomb core sandwiched between a porous facesheet and an impervious backing plate. These resonant absorbing structures are integrated into the nacelle wall and are very ef- ficient over a limited bandwidth centered on their resonance frequency. Increased noise suppression bandwidth and greater suppression at lower frequencies is typically achieved for conventional liners by increasing the liner depth and incorporating thin porous septa into the honeycomb core. However, constraints on liner depth in modern high by-pass engine nacelles severely limit the suppression bandwidth extension to lower frequencies. Also, current honeycomb core liners may not be suitable for irregular geometric volumes heretofore not considered. It is of interest, therefore, to find ways to circumvent liner depth restrictions and resonator cavity shape constraints. One way to increase effective liner depth is to skew the honeycomb core axis relative to the porous facesheet surface. Other possibilities are to alter resonator cavity shape, e.g. high aspect ratio, narrow channels that possibly include right angle bends, 180. channel fold-backs, and splayed channel walls to conform to irregular geometric constraints. These possibilities constitute the practical motivation for expanding impedance modeling capability to include unconventional resonator orientations and shapes. The work reported in this paper is

  8. Skew And Twist Resistant Hydrodynamic Rotary Shaft Seal

    DOEpatents

    Dietle, Lannie; Kalsi, Manmohan Singh

    2000-03-14

    A hydrodynamically lubricated squeeze packing type rotary shaft seal suitable for lubricant retention and environmental exclusion which incorporates one or more resilient protuberances which and cooperate with the gland walls to hold the seal straight in its installation groove in unpressurized and low pressure lubricant retention applications thereby preventing skew-induced wear caused by impingement of abrasive contaminants present in the environment, and which also serve as radial bearings to prevent tipping of the seal within its installation gland. Compared to prior art, this invention provides a dramatic reduction of seal and shaft wear in abrasive environments and provides a significant increase in seal life.

  9. Wigner-Yanase skew information as tests for quantum entanglement

    SciTech Connect

    Chen Zeqian

    2005-05-15

    A Bell-type inequality is proposed in terms of Wigner-Yanase skew information, which is quadratic and involves only one local spin observable at each site. This inequality presents a hierarchic classification of all states of multipartite quantum systems from separable to fully entangled states, which is more powerful than the one presented by quadratic Bell inequalities from two-entangled to fully entangled states. In particular, it is proved that the inequality provides an exact test to distinguish entangled from nonentangled pure states of two qubits. Our inequality sheds considerable light on relationships between quantum entanglement and information theory.

  10. Correlating the skewness and kurtosis of baryon number distributions

    NASA Astrophysics Data System (ADS)

    Fu, Wei-jie; Pawlowski, Jan M.

    2016-05-01

    The skewness and the kurtosis of the baryon number distributions are computed within QCD-improved low energy effective models including quantum thermal and density fluctuations. The results are compared with the Beam Energy Scan experiment at RHIC. The theoretical results agree with the experimental measurements up to errors, for the collision energy √{s }≥19.6 GeV . For smaller collision energies a discrepancy between theoretical and experimental results develops. This discrepancy partially relates to the lack of precision of the current setup for small collision energies. It is outlined how this deficiency can be overcome.

  11. Skew deflection of magnetic vortices in a field gradient

    NASA Astrophysics Data System (ADS)

    Papanicolaou, N.

    1994-07-01

    Magnetic vortices with a nonvanishing winding number, the strictly two-dimensional analogs of realistic magnetic bubbles, are studied within the isotropic Heisenberg model. In particular, we present a numerical simulation of their dynamics under the influence of an applied magnetic field gradient. In addition to verifying some known theoretical results concerning the gross features of skew deflection, in analogy with the Hall motion of an electron, we are able to exhibit some important details of the dynamics of the vortex around its guiding center.

  12. Characterising Uncertainty in Expert Assessments: Encoding Heavily Skewed Judgements

    PubMed Central

    O’Leary, Rebecca A.; Low-Choy, Samantha; Fisher, Rebecca; Mengersen, Kerrie; Caley, M. Julian

    2015-01-01

    When limited or no observed data are available, it is often useful to obtain expert knowledge about parameters of interest, including point estimates and the uncertainty around these values. However, it is vital to elicit this information appropriately in order to obtain valid estimates. This is particularly important when the experts’ uncertainty about these estimates is strongly skewed, for instance when their best estimate is the same as the lowest value they consider possible. Also this is important when interest is in the aggregation of elicited values. In this paper, we compare alternative distributions for describing such estimates. The distributions considered include the lognormal, mirror lognormal, Normal and scaled Beta. The case study presented here involves estimation of the number of species in coral reefs, which requires eliciting counts within broader taxonomic groups, with highly skewed uncertainty estimates. This paper shows substantial gain in using the scaled Beta distribution, compared with Normal or lognormal distributions. We demonstrate that, for this case study on counting species, applying the novel encoding methodology developed in this paper can facilitate the acquisition of more rigorous estimates of (hierarchical) count data and credible bounds. The approach can also be applied to the more general case of enumerating a sampling frame via elicitation. PMID:26517835

  13. Male reproductive skew, paternal relatedness, and female social relationships.

    PubMed

    Schülke, Oliver; Ostner, Julia

    2008-07-01

    Female social relationships among primates are thought to be shaped by socio-ecological factors and phylogenetic constraints. We suggest that patterns of paternal relatedness among females influence measures of social tolerance that have been used to classify species into different social relationship categories. As kin support and kin preference have only been measured for matrilineal kin and related individuals exchange less aggression and have a higher conciliatory tendency, the observed low nepotism levels and high tolerance levels may be an artifact of hidden paternal relatedness among the nonkin category. Using comparative data on macaques, we investigate this hypothesis using male reproductive skew as a proxy for paternal relatedness. Within the limitations of the study we show that populations classified as being less nepotistic, and more tolerant exhibit higher levels of reproductive skew. This first result and the reasoning behind may motivate future students of social relationships to take paternal relatedness into consideration. Potential implications of this finding if repeated with larger samples include that variation in aspects of macaque social relationships may be explained without considering phylogeny or the strength of between-group contest competition for food. PMID:18421769

  14. Crossover ensembles of random matrices and skew-orthogonal polynomials

    SciTech Connect

    Kumar, Santosh; Pandey, Akhilesh

    2011-08-15

    Highlights: > We study crossover ensembles of Jacobi family of random matrices. > We consider correlations for orthogonal-unitary and symplectic-unitary crossovers. > We use the method of skew-orthogonal polynomials and quaternion determinants. > We prove universality of spectral correlations in crossover ensembles. > We discuss applications to quantum conductance and communication theory problems. - Abstract: In a recent paper (S. Kumar, A. Pandey, Phys. Rev. E, 79, 2009, p. 026211) we considered Jacobi family (including Laguerre and Gaussian cases) of random matrix ensembles and reported exact solutions of crossover problems involving time-reversal symmetry breaking. In the present paper we give details of the work. We start with Dyson's Brownian motion description of random matrix ensembles and obtain universal hierarchic relations among the unfolded correlation functions. For arbitrary dimensions we derive the joint probability density (jpd) of eigenvalues for all transitions leading to unitary ensembles as equilibrium ensembles. We focus on the orthogonal-unitary and symplectic-unitary crossovers and give generic expressions for jpd of eigenvalues, two-point kernels and n-level correlation functions. This involves generalization of the theory of skew-orthogonal polynomials to crossover ensembles. We also consider crossovers in the circular ensembles to show the generality of our method. In the large dimensionality limit, correlations in spectra with arbitrary initial density are shown to be universal when expressed in terms of a rescaled symmetry breaking parameter. Applications of our crossover results to communication theory and quantum conductance problems are also briefly discussed.

  15. Skewed sex ratios in India: "physician, heal thyself".

    PubMed

    Patel, Archana B; Badhoniya, Neetu; Mamtani, Manju; Kulkarni, Hemant

    2013-06-01

    Sex selection, a gender discrimination of the worst kind, is highly prevalent across all strata of Indian society. Physicians have a crucial role in this practice and implementation of the Indian Government's Pre-Natal Diagnostic Techniques Act in 1996 to prevent the misuse of ultrasound techniques for the purpose of prenatal sex determination. Little is known about family preferences, let alone preferences among families of physicians. We investigated the sex ratios in 946 nuclear families with 1,624 children, for which either one or both parents were physicians. The overall child sex ratio was more skewed than the national average of 914. The conditional sex ratios decreased with increasing number of previous female births, and a previous birth of a daughter in the family was associated with a 38 % reduced likelihood of a subsequent female birth. The heavily skewed sex ratios in the families of physicians are indicative of a deeply rooted social malady that could pose a critical challenge in correcting the sex ratios in India. PMID:23322380

  16. Pattern formation of underwater sand ripples with a skewed drive.

    PubMed

    Bundgaard, F; Ellegaard, C; Scheibye-Knudsen, K; Bohr, T; Sams, T

    2004-12-01

    In this paper we present an experimental study of the dynamics of underwater sand ripples when a regular pattern of ripples is subjected to a skewed oscillatory flow, i.e., one not perpendicular to the direction of the ripple crests. Striking patterns with new, superposed ripples on top of the original ones occur very quickly with a characteristic angle, which is, in general, not perpendicular to the flow. A slower, more complex transition then follows, leading to the final state where the ripples are again perpendicular to the flow. We investigate the variation of the superposed pattern as a function of the direction, amplitude, and frequency of the drive, and as a function of the viscosity (by changing the temperature). We quantify the dynamics of the entire transition process and finally study the grain motion around idealized (solid) skewed ripples. This leads to a characteristic mean path of a single particle. The path has a shape close to a parallelogram, with no apparent connection to the pattern of real, superposed ripples. On the other hand, a thin layer of sand sprinkled on the solid ripples leads to qualitatively similar patterns. PMID:15697484

  17. Tissue-specific patterns of allelically-skewed DNA methylation

    PubMed Central

    Marzi, Sarah J.; Meaburn, Emma L.; Dempster, Emma L.; Lunnon, Katie; Paya-Cano, Jose L.; Smith, Rebecca G.; Volta, Manuela; Troakes, Claire; Schalkwyk, Leonard C.; Mill, Jonathan

    2016-01-01

    ABSTRACT While DNA methylation is usually thought to be symmetrical across both alleles, there are some notable exceptions. Genomic imprinting and X chromosome inactivation are two well-studied sources of allele-specific methylation (ASM), but recent research has indicated a more complex pattern in which genotypic variation can be associated with allelically-skewed DNA methylation in cis. Given the known heterogeneity of DNA methylation across tissues and cell types we explored inter- and intra-individual variation in ASM across several regions of the human brain and whole blood from multiple individuals. Consistent with previous studies, we find widespread ASM with > 4% of the ∼220,000 loci interrogated showing evidence of allelically-skewed DNA methylation. We identify ASM flanking known imprinted regions, and show that ASM sites are enriched in DNase I hypersensitivity sites and often located in an extended genomic context of intermediate DNA methylation. We also detect examples of genotype-driven ASM, some of which are tissue-specific. These findings contribute to our understanding of the nature of differential DNA methylation across tissues and have important implications for genetic studies of complex disease. As a resource to the community, ASM patterns across each of the tissues studied are available in a searchable online database: http://epigenetics.essex.ac.uk/ASMBrainBlood. PMID:26786711

  18. Experimental and finite element studies on free vibration of skew plates

    NASA Astrophysics Data System (ADS)

    Srinivasa, C. V.; Suresh, Y. J.; Prema Kumar, W. P.

    2014-03-01

    The present paper deals with the experimental and finite element studies carried out on free vibration of isotropic and laminated composite skew plates. The natural frequencies were determined using CQUAD8 finite element of MSC/NASTRAN and comparison made between the experimental values and the finite element solution. The effects of the skew angle and aspect ratio on the natural frequencies of isotropic skew plates were studied. The effects of skew angle, aspect ratio, fiber orientation angle and laminate stacking sequence (keeping total number of layers in the laminate constant) on the natural frequencies of antisymmetric laminated composite skew plates were also studied. The experimental values of the natural frequencies are in good agreement with the finite element solution. The natural frequencies generally increase with an increase in the skew angle for any given value of aspect ratio.

  19. Max-Packet Generation Process For Removing Skew In Network Multimedia Communication- A Mathematical Model

    NASA Astrophysics Data System (ADS)

    Kandar, S.; Roy, K.; Barman, M.; Bhunia, C. T.

    2009-07-01

    Multimedia data are sensed by human. These types of data are error tolerable to some extent but delay intolerable. To provide multimedia services with a guaranteed QoS is a research challenge. The two important parameters that degrade QoS are jittering & Skew. Researchers studied different methods for reducing jittering & skew. Earlier investigations attempted to use buffer management and introducing variable delay in delivering buffer to meet the challenges of jittering and skew. In the current work, we investigate Max-packet (Large packet made of data of different services) to reduce the effect of skew.

  20. Skew-normal/independent linear mixed models for censored responses with applications to HIV viral loads

    PubMed Central

    Bandyopadhyay, Dipankar; Lachos, Victor H.; Castro, Luis M.; Dey, Dipak K.

    2012-01-01

    Often in biomedical studies, the routine use of linear mixed-effects models (based on Gaussian assumptions) can be questionable when the longitudinal responses are skewed in nature. Skew-normal/elliptical models are widely used in those situations. Often, those skewed responses might also be subjected to some upper and lower quantification limits (viz. longitudinal viral load measures in HIV studies), beyond which they are not measurable. In this paper, we develop a Bayesian analysis of censored linear mixed models replacing the Gaussian assumptions with skew-normal/independent (SNI) distributions. The SNI is an attractive class of asymmetric heavy-tailed distributions that includes the skew-normal, the skew-t, skew-slash and the skew-contaminated normal distributions as special cases. The proposed model provides flexibility in capturing the effects of skewness and heavy tail for responses which are either left- or right-censored. For our analysis, we adopt a Bayesian framework and develop a MCMC algorithm to carry out the posterior analyses. The marginal likelihood is tractable, and utilized to compute not only some Bayesian model selection measures but also case-deletion influence diagnostics based on the Kullback-Leibler divergence. The newly developed procedures are illustrated with a simulation study as well as a HIV case study involving analysis of longitudinal viral loads. PMID:22685005

  1. New bounded skew central difference scheme. Part 1: Formulation and testing

    SciTech Connect

    Moukalled, F.; Darwish, M.

    1997-01-01

    The skew central difference scheme is combined with the normalized variable formulation to yield a new bounded skew central difference scheme. The newly developed scheme is tested and compared with the upwind scheme, the bounded skew upwind scheme, and the high-resolution SMART scheme by solving four problems: (1) pure convection of a step profile in an oblique velocity field; (2) sudden expansion of an oblique flow field in a rectangular cavity; (3) driven flow in a skew cavity; and (4) gradual expansion in an axisymmetric, nonorthogonal channel. Results generated reveal the new scheme to be bounded and to be the most accurate among those investigated.

  2. Techniques to estimate generalized skew coefficients of annual peak streamflow for natural basins in Texas

    USGS Publications Warehouse

    Judd, Linda J.; Asquith, William H.; Slade, Raymond M., Jr.

    1996-01-01

    This report presents two techniques to estimate generalized skew coefficients used for log-Pearson Type III peak-streamflow frequency analysis of natural basins in Texas. A natural basin has less than 10 percent impervious cover, and less than 10 percent of its drainage area is controlled by reservoirs. The estimation of generalized skew coefficients is based on annual peak and historical peak streamflow for all U.S. Geological Survey streamflow-gaging stations having at least 20 years of annual peak-streamflow record from natural basins in Texas. Station skew coefficients calculated for each of 255 Texas stations were used to estimate generalized skew coefficients for Texas. One technique to estimate generalized skew coefficients involved the use of regression equations developed for each of eight regions in Texas, and the other involved development of a statewide map of generalized skew coefficients. The weighted mean of the weighted mean standard errors of the regression equations for the eight regions is 0.36 log10 skew units, and the weighted mean standard error of the map is 0.35 log10 skew units. The technique based on the map is preferred for estimating generalized skew coefficients because of its smooth transition from one region of the State to another.

  3. Evaluate the Options of Implementing Skew Quadrupoles in the High Energy Ring

    SciTech Connect

    Cai, Yunhai

    1999-03-09

    There are six skew quadrupoles needed in each side of the interaction region to compensate the effects of coupling and vertical dispersion due to the solenoid detector. Two of those skew quadrupoles are at the location of the first pair of the local chromatic sextupoles in the arcs adjacent the interaction region. To avoid introducing high order aberration, the skew quadrupoles could not be placed between the sextupoles pair. In this note, we evaluate two options of implementing the skew quadrupoles at those locations, namely adding trim coil into the sextupoles or vertically displacing the sextupoles.

  4. COMPENSATION OF FAST KICKER ROLLS WITH SKEW QUADRUPOLES

    SciTech Connect

    Pinayev, I.

    2011-03-28

    The development of the third generation light sources lead to the implementation of the top-up operation, when injection occurs while users collect data. The beam excursions due to the non-closure of the injection bump can spoil the data and need to be suppressed. In the horizontal plane compensation can be achieved by adjusting timing and kick amplitudes. The rolls of the kicker magnets create non-closure in the vertical plane and usually there is no means for correction. In the paper we describe proposed compensation scheme utilizing two skew quadrupoles placed inside the injection bump. The third generation light sources implement top-up operation firstly introduced at Advanced Photon Source. In this mode the circulating beam current is supported near constant by frequent injection of small charge, while photon beam is delivered for users. The beam perturbations caused by the mismatched injection bump can provide undesired noise in the user data. Usually the injection trigger is distributed to the users end stations so that those affected would be able to blank data acquisition. Nevertheless, as good operational practice such transients should be suppressed as much as possible. In the horizontal plane (which is commonly used for injection) one can adjust individual kicker strength as well as trigger delay while observing motion of the stored beam centroid. In the vertical plane such means are unavailable in the most cases. The possible solutions include dedicated weak vertical kickers and motorized adjustment of the roll angle of the injection kickers. Both abovementioned approaches are expensive and can significantly deteriorate reliability. We suggest two employ two skew quadrupoles (to correct both angle and position) placed inside the injection bump. In this case the beam position itself serves as measure of the kicker strength (assuming that kickers are well matched) and vertical kicks from the skew quadrupoles will be self synchronized with injection bump

  5. On skew tau-functions in higher spin theory

    NASA Astrophysics Data System (ADS)

    Melnikov, D.; Mironov, A.; Morozov, A.

    2016-05-01

    Recent studies of higher spin theory in three dimensions concentrate on Wilson loops in Chern-Simons theory, which in the classical limit reduce to peculiar corner matrix elements between the highest and lowest weight states in a given representation of SL( N ). Despite these "skew" tau-functions can seem very different from conventional ones, which are the matrix elements between the two highest weight states, they also satisfy the Toda recursion between different fundamental representations. Moreover, in the most popular examples they possess simple representations in terms of matrix models and Schur functions. We provide a brief introduction to this new interesting field, which, after quantization, can serve as an additional bridge between knot and integrability theories.

  6. Cracked shells under skew-symmetric loading. [Reissner theory

    NASA Technical Reports Server (NTRS)

    Delale, F.

    1981-01-01

    The general problem of a shell containing a through crack in one of the principal planes of curvature and under general skew-symmetric loading is considered. By employing a Reissner type shell theory which takes into account the effect of transverse shear strains, all boundary conditions on the crack surfaces are satisfied separately. Consequently, unlike those obtained from the classical shell theory, the angular distributions of the stress components around the crack tips are shown to be identical to the distributions obtained from the plane and anti-plane elasticity solutions. Results are given for axially and circumferentially cracked cylindrical shells, spherical shells, and toroidal shells under uniform in-plane shearing, out of plane shearing, and torsion. The problem is formulated for specially orthostropic materials, therefore, the effect of orthotropy on the results is also studied.

  7. Quantum uncertainty of mixed states based on skew information

    SciTech Connect

    Luo Shunlong

    2006-02-15

    The uncertainty of a mixed state has two quite different origins: classical mixing and quantum randomness. While the classical aspect (mixedness) is significantly quantified by the von Neumann entropy, it seems that we still do not have a well accepted measure of quantum uncertainty. In terms of the skew information introduced by Wigner and Yanase in 1963 in the context of quantum measurements, we will propose an intrinsic measure for synthesizing quantum uncertainty of a mixed state and investigate its fundamental properties. We illustrate how it arises naturally from a naive hidden-variable approach to entanglement and how it exhibits a simple relation to the notion of negativity, which is an entanglement monotone introduced quite recently. We further show that it has a dramatic nonextensive feature resembling the probability law relating operations of two events. This measure of quantum uncertainty provides an alternative quantity complementary to the von Neumann entropy for studying mixedness and quantum correlations.

  8. Restoring the skew quadrupole moment in the Tevatron dipoles

    SciTech Connect

    Harding, D.J.; Bauer, P.C.; Blowers, J.N.; DiMarco, J.; Glass, H.D.; Hanft, R.W.; Carson, J.A.; Robotham, W.F.; Tartaglia, M.A.; Tompkins, J.C.; Velev, G.; /Fermilab

    2005-05-01

    In early 2003 it was realized that mechanical changes in the Tevatron dipoles had led to a deterioration of the magnetic field quality that was hindering operation of the accelerator. After extensive study, a remediation program was started in late 2003 that will continue through 2005. The mechanical and magnetic effects are discussed. The readjustment process and experience are reported, along with other observations on aging magnets. In January 2003 two lines of inquiry converged, leading to the recognition that the severe betatron coupling that was hindering operation of the Tevatron could be explained by a systematic shift on the skew quadrupole field in the dipole magnets of the same size expected from observed mechanical movement of the coils inside the magnet yokes [1]. This paper reports on subsequent magnet studies that were conducted in parallel with additional beam studies and accelerator modeling [2] exploring the feasibility of the eventual remediation effort [3].

  9. GC skew is a conserved property of unmethylated CpG island promoters across vertebrates

    PubMed Central

    Hartono, Stella R.; Korf, Ian F.; Chédin, Frédéric

    2015-01-01

    GC skew is a measure of the strand asymmetry in the distribution of guanines and cytosines. GC skew favors R-loops, a type of three stranded nucleic acid structures that form upon annealing of an RNA strand to one strand of DNA, creating a persistent RNA:DNA hybrid. Previous studies show that GC skew is prevalent at thousands of human CpG island (CGI) promoters and transcription termination regions, which correspond to hotspots of R-loop formation. Here, we investigated the conservation of GC skew patterns in 60 sequenced chordates genomes. We report that GC skew is a conserved sequence characteristic of the CGI promoter class in vertebrates. Furthermore, we reveal that promoter GC skew peaks at the exon 1/ intron1 junction and that it is highly correlated with gene age and CGI promoter strength. Our data also show that GC skew is predictive of unmethylated CGI promoters in a range of vertebrate species and that it imparts significant DNA hypomethylation for promoters with intermediate CpG densities. Finally, we observed that terminal GC skew is conserved for a subset of vertebrate genes that tend to be located significantly closer to their downstream neighbors, consistent with a role for R-loop formation in transcription termination. PMID:26253743

  10. Testing reproductive skew models in a communally breeding bird, the pukeko, Porphyrio porphyrio

    PubMed Central

    Jamieson, I. G.

    1997-01-01

    Recent attempts to explain variation among social species in the degree to which reproduction is shared among group members are focused on what are known as reproductive skew models. Reproduction within social groups can vary from an even distribution among all adults (i.e. low skew) to complete monopolization by a dominant individual (high skew). Three critical predictions derived from these models have remained largely untested: (1) reduced chances of independent breeding due to strong ecological constraints results in high reproductive skew; (2) the lower the genetic relatedness within social groups the lower the skew; and, counter-intuitively, (3) dominance-related aggression will be more prevalent in social groups composed of close kin where reproductive skew is predicted to be high. Here I test these predictions by comparing two populations of the communally breeding pukeko (Porphyrio porphyrio), which show extremes in social organization, namely social groups consisting of close kin versus groups made up of unrelated breeders. I report evidence from both cobreeding males and females in support of the above predictions. The results also indicate that low reproductive skew among unrelated group members may be prevalent in social species that possess weapons that can inflict serious injury in situations where reproductive competition may escalate to fighting. The consistency between these results and those from studies of social insects suggests that reproductive skew models may represent a unifying framework for understanding the factors shaping complex animal societies.

  11. Assessment of seismic performance of skew reinforced concrete box girder bridges

    NASA Astrophysics Data System (ADS)

    Abdel-Mohti, Ahmed; Pekcan, Gokhan

    2013-12-01

    The seismic vulnerability of highway bridges remains an important problem and has received increased attention as a consequence of unprecedented damage observed during several major earthquakes. A significant number of research studies have examined the performance of skew bridges under service and seismic loads. The results of these studies are particularly sensitive to modeling assumptions in view of the interacting parameters. In the present study, three-dimensional improved beam-stick models of two-span highway bridges with skew angles varying from 0° to 60° are developed to investigate the seismic response characteristics of skew box girder bridges. The relative accuracy of beam-stick models is verified against counterpart finite element models. The effect of various parameters and conditions on the overall seismic response was examined such as skew angle, ground motion intensity, soil condition, abutment support conditions, bridge aspect ratio, and foundation-base conditions. The study shows that the improved beam-stick models can be used to conduct accurate nonlinear time history analysis of skew bridges. Skew angle and interacting parameters were found to have significant effect on the behavior of skewed highway bridges. Furthermore, the performance of shear keys may have a predominant effect on the overall seismic response of the skew bridges.

  12. No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans

    PubMed Central

    Bolduc, Véronique; Chagnon, Pierre; Provost, Sylvie; Dubé, Marie-Pierre; Belisle, Claude; Gingras, Marianne; Mollica, Luigina; Busque, Lambert

    2007-01-01

    Skewing of X chromosome inactivation (XCI) can occur in normal females and increases in tissues with age. The mechanisms underlying skewing in normal females, however, remain controversial. To better understand the phenomenon of XCI in nondisease states, we evaluated XCI patterns in epithelial and hematopoietic cells of over 500 healthy female mother-neonate pairs. The incidence of skewing observed in mothers was twice that observed in neonates, and in both cohorts, the incidence of XCI was lower in epithelial cells than hematopoietic cells. These results suggest that XCI incidence varies by tissue type and that age-dependent mechanisms can influence skewing in both epithelial and hematopoietic cells. In both cohorts, a correlation was identified in the direction of skewing in epithelial and hematopoietic cells, suggesting common underlying skewing mechanisms across tissues. However, there was no correlation between the XCI patterns of mothers and their respective neonates, and skewed mothers gave birth to skewed neonates at the same frequency as nonskewed mothers. Taken together, our data suggest that in humans, the XCI pattern observed at birth does not reflect a single heritable genetic locus, but rather corresponds to a complex trait determined, at least in part, by selection biases occurring after XCI. PMID:18097474

  13. GC skew is a conserved property of unmethylated CpG island promoters across vertebrates.

    PubMed

    Hartono, Stella R; Korf, Ian F; Chédin, Frédéric

    2015-11-16

    GC skew is a measure of the strand asymmetry in the distribution of guanines and cytosines. GC skew favors R-loops, a type of three stranded nucleic acid structures that form upon annealing of an RNA strand to one strand of DNA, creating a persistent RNA:DNA hybrid. Previous studies show that GC skew is prevalent at thousands of human CpG island (CGI) promoters and transcription termination regions, which correspond to hotspots of R-loop formation. Here, we investigated the conservation of GC skew patterns in 60 sequenced chordates genomes. We report that GC skew is a conserved sequence characteristic of the CGI promoter class in vertebrates. Furthermore, we reveal that promoter GC skew peaks at the exon 1/ intron1 junction and that it is highly correlated with gene age and CGI promoter strength. Our data also show that GC skew is predictive of unmethylated CGI promoters in a range of vertebrate species and that it imparts significant DNA hypomethylation for promoters with intermediate CpG densities. Finally, we observed that terminal GC skew is conserved for a subset of vertebrate genes that tend to be located significantly closer to their downstream neighbors, consistent with a role for R-loop formation in transcription termination. PMID:26253743

  14. Skewness of cloud droplet spectrum and an improved estimation for its relative dispersion

    NASA Astrophysics Data System (ADS)

    Liu, Yu; Lu, Chunsong; Li, Weiliang

    2016-05-01

    The relative dispersion of the cloud droplet spectrum is a very important parameter in describing and modeling cloud microphysical processes. Based on the definition of skewness as well as theoretical and data analyses, a linear fitting relationship (α = 2.91ɛ-0.59) between skewness (α) and relative dispersion (ɛ) is established and a new method is developed to estimate the relative dispersion of the cloud droplet spectrum. The new method does not depend on any assumption of a particular distribution for the cloud droplet spectrum and has broader applicability than the previous methods. Comparisons of the three methods for the relative dispersion with the observed data supported the following conclusions. (1) The skewness of the cloud droplet spectrum is asymmetrically distributed. An assumption of zero skewness in quantifying the relative dispersion inevitably results in relatively large deviations from the observations. Errors of the estimated relative dispersion due to the omission of the skewness term are not solely related to the skewness, but rather to the product of the skewness and relative dispersion. (2) The use of the assumption that the cloud droplet spectrum takes a gamma distribution is similar to the assumption that the skewness is twice the relative dispersion. This leads to a better accuracy in estimating the relative dispersion than that with zero skewness assumption. (3) Comparisons with observations show that the new method is more accurate than the one under gamma distribution assumption and is the best among all the three methods. (4) It is believed that finding a better correlation between the skewness and the relative dispersion would further reduce the deviations for the estimated relative dispersion.

  15. Study of rolling element dynamic interactions with separator and raceway paths. Roller skewing measurements in roller bearings

    NASA Technical Reports Server (NTRS)

    Nypan, L. J.

    1980-01-01

    Measurements of roller skewing in a 118 mm bore roller bearing operating at shaft speeds to 12000 rpm are reported. High speed motion pictures of a modified roller were taken through a derotation prism to record skewing as the roller moved through loaded and unloaded regions of the bearing. Subsequent frame by frame measurement of the photographic film provided information on roller skewing. Radial and tangential skew amplitudes of .4 to .5 degrees were observed with .5 degree misalignment.

  16. Time Variations of Scour Below Submerged Skewed Pipelines

    NASA Astrophysics Data System (ADS)

    Yusoff, M. A. M.; Azamathulla, H. M.; Ghani, A. A.

    2016-07-01

    The presence of pipe across river initiates the piping effect combined with the stagnation eddy and vortex system in the vicinity of the pipeline. The main objective of the research is to investigate the physics of scour below skewed pipeline in river crossing as well as the time variations of the scour development. In this study, the experiments were conducted for four different angles of pipe (30°, 45°, 60° and 90°) across a channel and placed on the sediment bed with e/D = 0. The scour development for flow shallowness y/D = 3 and y/D = 4, initiated at downstream side of the pipe, where the bed sediment appeared to be ejected from the bed due to the piping effect process. At the initial stage, the scour process for 150mm flow depth enlarged rapidly. Whilst, the scour process for 200 mm flow depth slowly developed and after certain time, the sediment bed scoured rapidly. The scour depth increased considerably at development stage and the suspended load near the bed especially below the pipe decreased significantly compared to the initial stage. The rate of sediment eroded from the sediment bed decreased at the stabilization phase. The equilibrium phase of the scour depth considered achieved as the dimensions of the scour hole do not change significantly.

  17. Regression for Skewed Biomarker Outcomes Subject to Pooling

    PubMed Central

    Mitchell, Emily M.; Lyles, Robert H.; Manatunga, Amita K.; Danaher, Michelle; Perkins, Neil J.; Schisterman, Enrique F.

    2014-01-01

    Summary Epidemiological studies involving biomarkers are often hindered by prohibitively expensive laboratory tests. Strategically pooling specimens prior to performing these lab assays has been shown to effectively reduce cost with minimal information loss in a logistic regression setting. When the goal is to perform regression with a continuous biomarker as the outcome, regression analysis of pooled specimens may not be straightforward, particularly if the outcome is right-skewed. In such cases, we demonstrate that a slight modification of a standard multiple linear regression model for poolwise data can provide valid and precise coefficient estimates when pools are formed by combining biospecimens from subjects with identical covariate values. When these x-homogeneous pools cannot be formed, we propose a Monte Carlo Expectation Maximization (MCEM) algorithm to compute maximum likelihood estimates (MLEs). Simulation studies demonstrate that these analytical methods provide essentially unbiased estimates of coefficient parameters as well as their standard errors when appropriate assumptions are met. Furthermore, we show how one can utilize the fully observed covariate data to inform the pooling strategy, yielding a high level of statistical efficiency at a fraction of the total lab cost. PMID:24521420

  18. Skew redundant MEMS IMU calibration using a Kalman filter

    NASA Astrophysics Data System (ADS)

    Jafari, M.; Sahebjameyan, M.; Moshiri, B.; Najafabadi, T. A.

    2015-10-01

    In this paper, a novel calibration procedure for skew redundant inertial measurement units (SRIMUs) based on micro-electro mechanical systems (MEMS) is proposed. A general model of the SRIMU measurements is derived which contains the effects of bias, scale factor error and misalignments. For more accuracy, the effect of lever arms of the accelerometers to the center of the table are modeled and compensated in the calibration procedure. Two separate Kalman filters (KFs) are proposed to perform the estimation of error parameters for gyroscopes and accelerometers. The predictive error minimization (PEM) stochastic modeling method is used to simultaneously model the effect of bias instability and random walk noise on the calibration Kalman filters to diminish the biased estimations. The proposed procedure is simulated numerically and has expected experimental results. The calibration maneuvers are applied using a two-axis angle turntable in a way that the persistency of excitation (PE) condition for parameter estimation is met. For this purpose, a trapezoidal calibration profile is utilized to excite different deterministic error parameters of the accelerometers and a pulse profile is used for the gyroscopes. Furthermore, to evaluate the performance of the proposed KF calibration method, a conventional least squares (LS) calibration procedure is derived for the SRIMUs and the simulation and experimental results compare the functionality of the two proposed methods with each other.

  19. Identification of Intellectual Disability Genes in Female Patients with a Skewed X-Inactivation Pattern.

    PubMed

    Fieremans, Nathalie; Van Esch, Hilde; Holvoet, Maureen; Van Goethem, Gert; Devriendt, Koenraad; Rosello, Monica; Mayo, Sonia; Martinez, Francisco; Jhangiani, Shalini; Muzny, Donna M; Gibbs, Richard A; Lupski, James R; Vermeesch, Joris R; Marynen, Peter; Froyen, Guy

    2016-08-01

    Intellectual disability (ID) is a heterogeneous disorder with an unknown molecular etiology in many cases. Previously, X-linked ID (XLID) studies focused on males because of the hemizygous state of their X chromosome. Carrier females are generally unaffected because of the presence of a second normal allele, or inactivation of the mutant X chromosome in most of their cells (skewing). However, in female ID patients, we hypothesized that the presence of skewing of X-inactivation would be an indicator for an X chromosomal ID cause. We analyzed the X-inactivation patterns of 288 females with ID, and found that 22 (7.6%) had extreme skewing (>90%), which is significantly higher than observed in the general population (3.6%; P = 0.029). Whole-exome sequencing of 19 females with extreme skewing revealed causal variants in six females in the XLID genes DDX3X, NHS, WDR45, MECP2, and SMC1A. Interestingly, variants in genes escaping X-inactivation presumably cause both XLID and skewing of X-inactivation in three of these patients. Moreover, variants likely accounting for skewing only were detected in MED12, HDAC8, and TAF9B. All tested candidate causative variants were de novo events. Hence, extreme skewing is a good indicator for the presence of X-linked variants in female patients. PMID:27159028

  20. Log Pearson type 3 quantile estimators with regional skew information and low outlier adjustments

    USGS Publications Warehouse

    Griffis, V.W.; Stedinger, J.R.; Cohn, T.A.

    2004-01-01

    [1] The recently developed expected moments algorithm (EMA) [Cohn et al., 1997] does as well as maximum likelihood estimations at estimating log-Pearson type 3 (LP3) flood quantiles using systematic and historical flood information. Needed extensions include use of a regional skewness estimator and its precision to be consistent with Bulletin 17B. Another issue addressed by Bulletin 17B is the treatment of low outliers. A Monte Carlo study compares the performance of Bulletin 17B using the entire sample with and without regional skew with estimators that use regional skew and censor low outliers, including an extended EMA estimator, the conditional probability adjustment (CPA) from Bulletin 17B, and an estimator that uses probability plot regression (PPR) to compute substitute values for low outliers. Estimators that neglect regional skew information do much worse than estimators that use an informative regional skewness estimator. For LP3 data the low outlier rejection procedure generally results in no loss of overall accuracy, and the differences between the MSEs of the estimators that used an informative regional skew are generally modest in the skewness range of real interest. Samples contaminated to model actual flood data demonstrate that estimators which give special treatment to low outliers significantly outperform estimators that make no such adjustment.

  1. Skewed birth sex ratio and premature mortality in elephants.

    PubMed

    Saragusty, Joseph; Hermes, Robert; Göritz, Frank; Schmitt, Dennis L; Hildebrandt, Thomas B

    2009-10-01

    Sex allocation theories predict equal offspring number of both sexes unless differential investment is required or some competition exists. Left undisturbed, elephants reproduce well and in approximately even numbers in the wild. We report an excess of males are born and substantial juvenile mortality occurs, perinatally, in captivity. Studbook data on captive births (CB, n=487) and premature deaths (PD, <5 years of age; n=164) in Asian and African elephants in Europe and North America were compared with data on Myanmar timber (Asian) elephants (CB, n=3070; PD, n=738). Growth in CB was found in three of the captive populations. A significant excess of male births occurred in European Asian elephants (ratio: 0.61, P=0.044) and in births following artificial insemination (0.83, P=0.003), and a numerical inclination in North American African elephants (0.6). While juvenile mortality in European African and Myanmar populations was 21-23%, it was almost double (40-45%) in all other captive populations. In zoo populations, 68-91% of PD were within 1 month of birth with stillbirth and infanticide being major causes. In Myanmar, 62% of juvenile deaths were at >6 months with maternal insufficient milk production, natural hazards and accidents being the main causes. European Asian and Myanmar elephants PD was biased towards males (0.71, P=0.024 and 0.56, P<0.001, respectively). The skewed birth sex ratio and high juvenile mortality hinder efforts to help captive populations become self-sustaining. Efforts should be invested to identify the mechanism behind these trends and seek solutions for them. PMID:19058933

  2. Skewness in large-scale structure and non-Gaussian initial conditions

    NASA Technical Reports Server (NTRS)

    Fry, J. N.; Scherrer, Robert J.

    1994-01-01

    We compute the skewness of the galaxy distribution arising from the nonlinear evolution of arbitrary non-Gaussian intial conditions to second order in perturbation theory including the effects of nonlinear biasing. The result contains a term identical to that for a Gaussian initial distribution plus terms which depend on the skewness and kurtosis of the initial conditions. The results are model dependent; we present calculations for several toy models. At late times, the leading contribution from the initial skewness decays away relative to the other terms and becomes increasingly unimportant, but the contribution from initial kurtosis, previously overlooked, has the same time dependence as the Gaussian terms. Observations of a linear dependence of the normalized skewness on the rms density fluctuation therefore do not necessarily rule out initially non-Gaussian models. We also show that with non-Gaussian initial conditions the first correction to linear theory for the mean square density fluctuation is larger than for Gaussian models.

  3. 12. Underside of Skew SpanHot Metal system on right, toward ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Underside of Skew Span-Hot Metal system on right, toward Rocker Bent. - Monongahela Connecting Railroad Company, Hot Metal Bridge, Spanning Monongahela River at mile post 3.1, Pittsburgh, Allegheny County, PA

  4. On some properties of reflected skew Brownian motions and applications to dispersion in heterogeneous media

    NASA Astrophysics Data System (ADS)

    Song, Shiyu; Wang, Suxin; Wang, Yongjin

    2016-08-01

    Motivated by the close connection between the skew Brownian motion and the random particle motion in heterogeneous media, we investigate the reflected skew Brownian motion and try to find out its relationship with the corresponding dispersion problem when there exists a reflecting boundary. Through the use of the knowledge of stochastic analysis, we provide some basic properties of reflected skew Brownian motions, including the transition density, the Laplace transform of the first passage time, and some related results. A simple method to generate the sample path is also proposed. At the end of this paper, we reveal the strong relationship between the reflected skew Brownian motion and the solute dispersion in the presence of a sharp interface and a reflecting boundary.

  5. Bridge No. 1363, First B&O Crossing, detail of skewed through ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bridge No. 1363, First B&O Crossing, detail of skewed through truss, looking west. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  6. Skewed west portal of Bridge No. 1363, First B&O Crossing, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Skewed west portal of Bridge No. 1363, First B&O Crossing, looking east. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  7. A comparison of the randomization test with the F test when error is skewed.

    PubMed

    Mewhort, D J K

    2005-08-01

    I compared the randomization/permutation test and the F test for a two-cell comparative experiment. I varied (1) the number of observations per cell, (2) the size of the treatment effect, (3) the shape of the underlying distribution of error and, (4) for cases with skewed error, whether or not the skew was correlated with the treatment. With normal error, there was little difference between the tests. When error was skewed, by contrast, the randomization test was more sensitive than the F test, and if the amount of skew was correlated with the treatment, the advantage for the randomization test was both large and positively correlated with the treatment. I conclude that, because the randomization test was never less powerful than the F test, it should replace the F test in routine work. PMID:16405137

  8. Estimating generalized skew of the log-Pearson Type III distribution for annual peak floods in Illinois

    USGS Publications Warehouse

    Oberg, Kevin A.; Mades, Dean M.

    1987-01-01

    Four techniques for estimating generalized skew in Illinois were evaluated: (1) a generalized skew map of the US; (2) an isoline map; (3) a prediction equation; and (4) a regional-mean skew. Peak-flow records at 730 gaging stations having 10 or more annual peaks were selected for computing station skews. Station skew values ranged from -3.55 to 2.95, with a mean of -0.11. Frequency curves computed for 30 gaging stations in Illinois using the variations of the regional-mean skew technique are similar to frequency curves computed using a skew map developed by the US Water Resources Council (WRC). Estimates of the 50-, 100-, and 500-yr floods computed for 29 of these gaging stations using the regional-mean skew techniques are within the 50% confidence limits of frequency curves computed using the WRC skew map. Although the three variations of the regional-mean skew technique were slightly more accurate than the WRC map, there is no appreciable difference between flood estimates computed using the variations of the regional-mean technique and flood estimates computed using the WRC skew map. (Peters-PTT)

  9. A study on the effects of a skewed distribution on the EWMA and MA charts

    NASA Astrophysics Data System (ADS)

    Liew, Jeng Young; Khoo, Michael Boon Chong; Neoh, Siang Gee

    2014-07-01

    The control chart is the most powerful tool in statistical process control. A control chart is a graphical display used to determine the presence of assignable causes so that prompt corrective actions can be taken to remove such causes before many nonconforming products are produced. The exponentially weighted moving average (EWMA) and moving average (MA) charts are very effective in detecting small and moderate shifts in the process mean. These two charts are constructed based on the properties of the normal distribution. In many practical applications, the validity of the normality assumption is always doubted as the process distribution could be skewed. A skewed distribution can result in a higher incidence of false alarms. This is due to the inconsistencies between the spread of a skewed distribution and the normality assumption employed in setting up a control chart. This paper studies the effects of a skewed distribution on the performances of the EWMA and MA charts, in terms of the charts' false alarm rates. We compare the in-control average run length (ARL0) performance of these two charts when the underlying distributions are normal and skewed. The gamma distribution is selected to represent the skewed distribution. A Monte Carlo simulation using the Statistical Analysis System (SAS) software is carried out to compute the necessary ARL0s. The findings of this study show that the ARL0 performance of the EWMA and MA charts is substantially affected by the skewed distribution. However, the MA chart is not as robust as the EWMA chart, in terms of the ARL0, when the distribution is skewed.

  10. Analytical study on failure process of reinforced concrete wall-type skewed pier

    NASA Astrophysics Data System (ADS)

    Kyoda, Hidehiro; Mikami, Takashi; Nishi, Hiroaki

    Wall-type reinforced concrete piers have been broadly constructed out of urban area under space limitation. However the deformation capacity against earthquake should be evaluated appropriately as a function of the skewed angle. This paper aims to grasp the behavior of wall-type skewed piers under cyclic loading using the three dimensional fiber model analysis. As a result, it was found that the fiber mode l analysis could simulate the experimental results before failure of the longitudinal reinforcement.

  11. Tracer experiments in the Rhine Basin: evaluation of the skewness of observed concentration distributions

    NASA Astrophysics Data System (ADS)

    van Mazijk, A.; Veling, E. J. M.

    2005-06-01

    Field studies reporting on the propagation of a pollution wave travelling down a river mostly show persistence of the temporal skewness. As a result, in the Rhine Alarm-Model a constant skewness coefficient (equal to 1) has been applied. The appropriateness of this assumption has been proven by tracer experiments. This finding seems to be in conflict with the solution of the transient storage equations of the one-dimensional Fickian-type diffusion equations, the so-called dead-zone model, showing a continuous decrease of the skewness with the distance. On the other hand, based on these equations as an initial-boundary value problem for the transport of a spill in a river with dead zones Schmid [Schmid, B.H., 2002. Persistence of skewness in longitudinal dispersion data: can the dead zone model explain it after all?. Journal of Hydraulic Engineering 128 (9), 848-854, September 1, ASCE], showed that the skewness can locally increase, if there are river reaches with different values of the mass-transfer coefficient between the main stream and the dead zone, or due to changing topography. This paper shows that by applying Schmid's [Schmid, B.H., 2002. Persistence of skewness in longitudinal dispersion data: can the dead zone model explain it after all?. Journal of Hydraulic Engineering 128 (9), 848-854, September 1, ASCE] approach to the River Rhine and its tributaries Mosel (Germany) and Aare (Switzerland), the observed persistence of the skewness can be reproduced, taking into account the changes in the river topography. Moreover, it is demonstrated that irregularities of the riverbed and banks, and vegetation along the river borders, resulting in 'natural dead zones', contribute to the persistence of the skewness. In addition, the physical processes behind the observed mass-transfer coefficient have been analysed.

  12. An Adaptive Method for Reducing Clock Skew in an Accumulative Z-Axis Interconnect System

    NASA Technical Reports Server (NTRS)

    Bolotin, Gary; Boyce, Lee

    1997-01-01

    This paper will present several methods for adjusting clock skew variations that occur in a n accumulative z-axis interconnect system. In such a system, delay between modules in a function of their distance from one another. Clock distribution in a high-speed system, where clock skew must be kept to a minimum, becomes more challenging when module order is variable before design.

  13. Static performance investigation of a skewed-throat multiaxis thrust-vectoring nozzle concept

    NASA Technical Reports Server (NTRS)

    Wing, David J.

    1994-01-01

    The static performance of a jet exhaust nozzle which achieves multiaxis thrust vectoring by physically skewing the geometric throat has been characterized in the static test facility of the 16-Foot Transonic Tunnel at NASA Langley Research Center. The nozzle has an asymmetric internal geometry defined by four surfaces: a convergent-divergent upper surface with its ridge perpendicular to the nozzle centerline, a convergent-divergent lower surface with its ridge skewed relative to the nozzle centerline, an outwardly deflected sidewall, and a straight sidewall. The primary goal of the concept is to provide efficient yaw thrust vectoring by forcing the sonic plane (nozzle throat) to form at a yaw angle defined by the skewed ridge of the lower surface contour. A secondary goal is to provide multiaxis thrust vectoring by combining the skewed-throat yaw-vectoring concept with upper and lower pitch flap deflections. The geometric parameters varied in this investigation included lower surface ridge skew angle, nozzle expansion ratio (divergence angle), aspect ratio, pitch flap deflection angle, and sidewall deflection angle. Nozzle pressure ratio was varied from 2 to a high of 11.5 for some configurations. The results of the investigation indicate that efficient, substantial multiaxis thrust vectoring was achieved by the skewed-throat nozzle concept. However, certain control surface deflections destabilized the internal flow field, which resulted in substantial shifts in the position and orientation of the sonic plane and had an adverse effect on thrust-vectoring and weight flow characteristics. By increasing the expansion ratio, the location of the sonic plane was stabilized. The asymmetric design resulted in interdependent pitch and yaw thrust vectoring as well as nonzero thrust-vector angles with undeflected control surfaces. By skewing the ridges of both the upper and lower surface contours, the interdependency between pitch and yaw thrust vectoring may be eliminated

  14. Sex ratios and skew models: the special case of evolution of cooperation in polistine wasps.

    PubMed

    Nonacs, Peter

    2002-07-01

    Cooperative breeding often involves reproductive dominance hierarchies. Such hierarchies have been proposed to form and to be maintained through an equitable skew in reproduction for both dominants and subordinates. The general form of skew models also predicts that cooperation can be stable only if cooperation greatly increases group reproductive success or subordinates are greatly constrained in their reproductive prospects relative to dominants. Neither, however, seems to be generally present in the colony initiation phase of temperate polistine wasps, although the behaviors of individuals within such groups are often consistent with skew model predictions. This apparent contradiction can be resolved in the context of a special case of the skew models that incorporate mother-offspring conflicts over sex ratios. Data suggest that all the needed preconditions are present for cooperating foundresses to gain an added benefit through producing male-biased investment ratios. Therefore, the special case model predicts that cooperation can evolve in Hymenoptera with both the observed high skews and reduced per capita group productivity. Further predictions of the special case model (e.g., mixed populations of single and multifoundresses) are also supported. Because the special case model is applicable only to haplodiploids, this may explain why cooperation in vertebrates rarely occurs without significant ecological or physiological constraints. Finally, comparisons to other social Hymenoptera taxa suggest that factors stabilizing cooperation between colony-initiating females may simultaneously constrain the evolution of morphologically specialized worker castes. PMID:18707502

  15. Generalized Skew Coefficients of Annual Peak Flows for Rural, Unregulated Streams in West Virginia

    USGS Publications Warehouse

    Atkins, John T.; Wiley, Jeffrey B.; Paybins, Katherine S.

    2009-01-01

    Generalized skew was determined from analysis of records from 147 streamflow-gaging stations in or near West Virginia. The analysis followed guidelines established by the Interagency Advisory Committee on Water Data described in Bulletin 17B, except that stations having 50 or more years of record were used instead of stations with the less restrictive recommendation of 25 or more years of record. The generalized-skew analysis included contouring, averaging, and regression of station skews. The best method was considered the one with the smallest mean square error (MSE). MSE is defined as the following quantity summed and divided by the number of peaks: the square of the difference of an individual logarithm (base 10) of peak flow less the mean of all individual logarithms of peak flow. Contouring of station skews was the best method for determining generalized skew for West Virginia, with a MSE of about 0.2174. This MSE is an improvement over the MSE of about 0.3025 for the national map presented in Bulletin 17B.

  16. Modeling absolute differences in life expectancy with a censored skew-normal regression approach

    PubMed Central

    Clough-Gorr, Kerri; Zwahlen, Marcel

    2015-01-01

    Parameter estimates from commonly used multivariable parametric survival regression models do not directly quantify differences in years of life expectancy. Gaussian linear regression models give results in terms of absolute mean differences, but are not appropriate in modeling life expectancy, because in many situations time to death has a negative skewed distribution. A regression approach using a skew-normal distribution would be an alternative to parametric survival models in the modeling of life expectancy, because parameter estimates can be interpreted in terms of survival time differences while allowing for skewness of the distribution. In this paper we show how to use the skew-normal regression so that censored and left-truncated observations are accounted for. With this we model differences in life expectancy using data from the Swiss National Cohort Study and from official life expectancy estimates and compare the results with those derived from commonly used survival regression models. We conclude that a censored skew-normal survival regression approach for left-truncated observations can be used to model differences in life expectancy across covariates of interest. PMID:26339544

  17. Skew-Laplace and Cell-Size Distribution in Microbial Axenic Cultures: Statistical Assessment and Biological Interpretation

    PubMed Central

    Julià, Olga; Vidal-Mas, Jaume; Panikov, Nicolai S.; Vives-Rego, Josep

    2010-01-01

    We report a skew-Laplace statistical analysis of both flow cytometry scatters and cell size from microbial strains primarily grown in batch cultures, others in chemostat cultures and bacterial aquatic populations. Cytometry scatters best fit the skew-Laplace distribution while cell size as assessed by an electronic particle analyzer exhibited a moderate fitting. Unlike the cultures, the aquatic bacterial communities clearly do not fit to a skew-Laplace distribution. Due to its versatile nature, the skew-Laplace distribution approach offers an easy, efficient, and powerful tool for distribution of frequency analysis in tandem with the flow cytometric cell sorting. PMID:20592754

  18. Skew-laplace and cell-size distribution in microbial axenic cultures: statistical assessment and biological interpretation.

    PubMed

    Julià, Olga; Vidal-Mas, Jaume; Panikov, Nicolai S; Vives-Rego, Josep

    2010-01-01

    We report a skew-Laplace statistical analysis of both flow cytometry scatters and cell size from microbial strains primarily grown in batch cultures, others in chemostat cultures and bacterial aquatic populations. Cytometry scatters best fit the skew-Laplace distribution while cell size as assessed by an electronic particle analyzer exhibited a moderate fitting. Unlike the cultures, the aquatic bacterial communities clearly do not fit to a skew-Laplace distribution. Due to its versatile nature, the skew-Laplace distribution approach offers an easy, efficient, and powerful tool for distribution of frequency analysis in tandem with the flow cytometric cell sorting. PMID:20592754

  19. Effective step-skew method for cogging torque reduction in surface-mounted permanent magnet synchronous motor

    NASA Astrophysics Data System (ADS)

    Kim, Tae-Woo; Chang, Jung-Hwan

    2013-08-01

    This paper suggests an effective step-skew method to reduce the cogging torque of a surface-mounted permanent magnet synchronous motor (SPMSM). The main concept of the proposed method is to adjust each step length by considering the non-uniform air gap flux density distribution in the axial direction. The results show that the proposed step-skew method reduces the net cogging torque compared with the conventional step-skew method and is more effective for smaller stacking lengths and larger skew steps.

  20. Skew harmonics suppression in electromagnets with application to the Advanced Light Source (ALS) storage ring corrector magnet design

    SciTech Connect

    Schlueter, R.D.; Halbach, K.

    1994-07-01

    An analytical expression for prediction of skew harmonics in an iron core combined function regular/skew dipole magnet due to arbitrarily positioned electromagnet coils is developed. A structured approach is presented for the suppression of an arbitrary number of harmonic components to arbitrarily low values. Application of the analytical harmonic strength calculations coupled to the structured harmonic suppression approach is presented in the context of the design of the ALS storage ring corrector magnets, where quadrupole, sextupole, and octupole skew harmonics were reduced to less than 1.0% of the skew dipole at the beam aperture radius r = 3.0 cm.

  1. Skew harmonics suppression in electromagnets with application to the Advanced Light Source (ALS) storage ring corrector magnet design

    SciTech Connect

    Schlueter, R.; Halbach, K.

    1993-09-01

    An analytical expression for prediction of skew harmonics in an iron core combined function regular/skew dipole magnet due to arbitrarily positioned electromagnet coils is developed. A structured approach is presented for the suppression of an arbitrary number of harmonic components to arbitrarily low values. Application of the analytical harmonic strength calculations coupled to the structured harmonic suppression approach is presented in the context of the design of the ALS storage ring corrector magnets, where quadrupole, sextupole, and octupole skew harmonics were reduced to less than 1.0% of the skew dipole at the beam aperture radius r = 3.0 cm.

  2. The log-dynamic brain: how skewed distributions affect network operations

    PubMed Central

    Buzsáki, György; Mizuseki, Kenji

    2014-01-01

    We often assume that the variables of functional and structural brain parameters — such as synaptic weights, the firing rates of individual neurons, the synchronous discharge of neural populations, the number of synaptic contacts between neurons and the size of dendritic boutons — have a bell-shaped distribution. However, at many physiological and anatomical levels in the brain, the distribution of numerous parameters is in fact strongly skewed with a heavy tail, suggesting that skewed (typically lognormal) distributions are fundamental to structural and functional brain organization. This insight not only has implications for how we should collect and analyse data, it may also help us to understand how the different levels of skewed distributions — from synapses to cognition — are related to each other. PMID:24569488

  3. Perceived quality of wood images influenced by the skewness of image histogram

    NASA Astrophysics Data System (ADS)

    Katsura, Shigehito; Mizokami, Yoko; Yaguchi, Hirohisa

    2015-08-01

    The shape of image luminance histograms is related to material perception. We investigated how the luminance histogram contributed to improvements in the perceived quality of wood images by examining various natural wood and adhesive vinyl sheets with printed wood grain. In the first experiment, we visually evaluated the perceived quality of wood samples. In addition, we measured the colorimetric parameters of the wood samples and calculated statistics of image luminance. The relationship between visual evaluation scores and image statistics suggested that skewness and kurtosis affected the perceived quality of wood. In the second experiment, we evaluated the perceived quality of wood images with altered luminance skewness and kurtosis using a paired comparison method. Our result suggests that wood images are more realistic if the skewness of the luminance histogram is slightly negative.

  4. Enhanced responsivity with skew ray excitation of reflection- and transmission-type refractometric sensors.

    PubMed

    Chen, George Y; Codemard, Christophe A; Lewis, Richard J; Jankowski, Lukasz; Chan, Jaclyn S; Gorman, Philip M; Zervas, Michalis N

    2014-07-01

    The responsivity of optical fibers to refractive index can be enhanced using high-order skew rays compared with using meridional rays. Skew rays can have a much higher number of reflections with increased interaction length along the core-cladding interface, which gives rise to stronger interactions with the external medium. Reflection/transmission-type refractometric sensors based on twin-coupled-core and multimode fibers showed one/two orders of magnitude increase in responsivity with skew ray excitation. The responsivity and sensitivity for the two types are ~2000%/RIU, ~1400%/RIU, and 4.9×10⁻⁵  RIU, 7.0×10⁻⁵  RIU, respectively. PMID:24978746

  5. Sensitivity of odd-harmonic amplitudes to open quotient and skewing quotient in glottal airflow

    PubMed Central

    Titze, Ingo R.

    2015-01-01

    It is well known that a half-sinusoid has no odd harmonics other than the fundamental. If glottal flow in phonation were to approximate this exact waveshape, which is generally unlikely, some misperception of pitch and loss of vowel intelligibility would occur. The sensitivity of the glottal waveshape to this special shape is explored by systematically varying two parameters, open quotient and skewing quotient. Mild asymmetry (open quotient below 0.45 or above 0.55 and/or skewing quotient greater than 2.0) equalizes the odd-even harmonic series. Singers and speakers avoid the exact symmetry by skewing the flow pulse with source-filter interaction. PMID:25618080

  6. Skewness in CMB temperature fluctuations from curved cosmic (super-)strings

    SciTech Connect

    Yamauchi, Daisuke; Sendouda, Yuuiti; Yoo, Chul-Moon; Naruko, Atsushi; Sasaki, Misao; Takahashi, Keitaro E-mail: sendouda@yukawa.kyoto-u.ac.jp E-mail: keitaro@a.phys.nagoya-u.ac.jp E-mail: misao@yukawa.kyoto-u.ac.jp

    2010-05-01

    We compute the one-point probability distribution function of small-angle cosmic microwave background temperature fluctuations due to curved cosmic (super-)strings with a simple model of string network by performing Monte Carlo simulations. Taking into account of the correlation between the curvature and the velocity of string segments, there appear non-Gaussian features, specifically non-Gaussian tails and a skewness, in the one-point pdf. The obtained sample skewness for the conventional field-theoretic cosmic strings is g{sub 1} ≈ −0.14, which is consistent with the result reported by Fraisse et al. We also discuss the dependence of the pdf on the intercommuting probability. We find that the standard deviation of the Gaussian part increases and non-Gaussian features are suppressed as the intercommuting probability decreases. For sufficiently small intercommuting probability, the skewness is given by ∼< (a few) × 10{sup −2}.

  7. A METHOD TO MEASURE THE SKEW QUADUPOLE STRENGTHS IN THE SIS-18 USING TWO BPMS.

    SciTech Connect

    FRANCHI,A.BEIER,T.KIRK,M.MORITZ,P.RUMOLO,G.TOMAS,R.

    2004-07-05

    In the GSI synchrotron SIS-18 a new set of skew quadrupoles has been installed to improve the multi-turn-injection. Anew method based on the measurement of the resonance driving terms (RDT) has been proposed to cross-check the nominal values and polarities of their gradients. Once a beam is transversely kicked, it experiences oscillations whose spectrum contains both the betatron tune line and secondary lines. The amplitude of each line is proportional to the strength of the multipoles, such as skew quadrupoles and sextupoles, present in the lattice. In this paper, a recursive algorithm to derive the magnet strength from the spectral lines and the application of this method to the eight skew quadrupoles in the SIS-18 are presented.

  8. Four-dimensional lattice rules generated by skew-circulant matrices.

    SciTech Connect

    Lyness, J. N.; Sorevik, T.; Mathematics and Computer Science; Univ. of Bergen

    2003-01-01

    We introduce the class of skew-circulant lattice rules. These are s-dimensional lattice rules that may be generated by the rows of an s x s skew-circulant matrix. (This is a minor variant of the familiar circulant matrix.) We present briefly some of the underlying theory of these matrices and rules. We are particularly interested in finding rules of specified trigonometric degree d. We describe some of the results of computer-based searches for optimal four-dimensional skew-circulant rules. Besides determining optimal rules for {delta} = d + 1 {<=} 47, we have constructed an infinite sequence of rules Q(4, {delta}) that has a limit rho index of 27/34 {approx} 0.79. This index is an efficiency measure, which cannot exceed 1, and is inversely proportional to the abscissa count.

  9. Modeling the effects of wave skewness and beach cusps on littoral sand transport

    USGS Publications Warehouse

    Haas, K.A.; Check, L.A.; Hanes, D.M.

    2008-01-01

    A process-based numerical modeling system is utilized for predicting littoral sand transport. The intent is to examine conditions slightly more complex than linear waves impinging upon a plane beach. Two factors that we examine are wave skewness and longshore varying bathymetry. An empirical model is used for calculating the skewed bottom wave orbital velocity. The advection of sediment due to the skewed wave velocity is larger and in the direction of the waves, opposite to the results with sinusoidal wave velocities, due to the increase in the bottom shear stress under the wave crests. The model system is also applied to bathymetry containing beach cusps. When the wave field has relatively weak longshore wave power, the currents and the littoral transport exhibit significant longshore variability, thereby altering the overall mean littoral transport.

  10. Effect of skewing the rotor teeth on the performance of doubly salient permanent magnet motors

    NASA Astrophysics Data System (ADS)

    Sheth, N. K.; Sekharbabu, A. R. C.; Rajagopal, K. R.

    2006-04-01

    This paper presents the effects of skewing the rotor teeth on the performance characteristics such as flux linkage, back emf, phase inductance, and reluctance torque of an 8/6 doubly salient permanent magnet motor using a simple method, which utilizes the results obtained from the two-dimensional finite element analysis. The optimum skewing angle is obtained as 12°-15° for the least ripple torque without much reduction in the back emf. Skewing the rotor teeth of an 8/6 doubly salient permanent magnet motor by 12°-15° will reduce the total harmonic distortion of the back emf profile to 29.69% from the original value of 44.69%. The reduction in the amplitude of the back emf in this case will be 18.79% only.

  11. Distribution of mean Doppler shift, spectral width, and skewness of coherent 50-MHz auroral radar backscatter

    SciTech Connect

    Watermann, J.; McNamara, A.G. ); Sofko, G.J.; Koehler, J.A. )

    1989-06-01

    Some 7,700 radio aurora spectra obtained from a six link 50-MHz CW radar network set up on the Canadian prairies were analyzed with respect to the distributions of mean Doppler shift, spectral width and skewness. A comparison with recently published SABRE results obtained at 153 MHz shows substantial differences in the distributions which are probably due to different experimental and geophysical conditions. The spectra are mostly broad with mean Doppler shifts close to zero (type II spectra). The typical groupings of type I and type III spectra are clearly identified. All types appear to be in general much more symmetric than those recorded with SABRE, and the skewness is only weakly dependent on the sign of the mean Doppler shift. Its distribution peaks near zero and shows a weak positive correlation with the type II Doppler shifts while the mostly positive type I Doppler shifts are slightly negatively correlated with the skewness.

  12. Generation of time histories with a specified auto spectral density, skewness, and kurtosis

    SciTech Connect

    Smallwood, D.O.

    1996-02-01

    Some dynamic environments are characterized by time histories that are not Gaussian. A more accurate simulation of these environments can be generated if a realization of a non Gaussian time history can be reproduced which has a specified auto spectral density (also called power spectral density) and a specified skewness and kurtosis (not necessarily the skewness and kurtosis of a Gaussian time history). The mean square of the waveform is reproduced if the spectrum is reproduced. Modern waveform reproduction techniques can be used to reproduce the realized waveform on an electrodynamic or electrohydraulic shaker. A method is presented for the generation of realizations of zero mean non Gaussian random time histories with a specified auto spectral density, skewness, and kurtosis. Kurtosis, defined in this paper as E[{chi}{sup 4}]/E{sup 2}[{chi}{sup 2}], greater than 3 can be realized. Realizations of the random process are generated with a generalization of shot noise.

  13. Measurement-induced nonlocality based on Wigner-Yanase skew information

    NASA Astrophysics Data System (ADS)

    Li, Lei; Wang, Qing-Wen; Shen, Shu-Qian; Li, Ming

    2016-04-01

    Measurement-induced nonlocality (MIN), which describes the maximum global effect caused by locally invariant measurements, was introduced by Luo and Fu (Phys. Rev. Lett., 106 (2011) 120401). In this paper, a new measure of MIN based on Wigner-Yanase skew information is proposed. It is shown that this measure not only has good computability but also eliminates the noncontractivity problem appearing in the original measure of MIN defined by the Hilbert-Schmidt norm. The analytical formulas of MIN based on Wigner-Yanase skew information for any pure states, (2× n) -dimensional mixed states, and some higher-dimensional symmetric states are presented. Furthermore, the tight upper bound to MIN based on Wigner-Yanase skew information in the general case is also derived.

  14. Elevated Mortality among Birds in Chernobyl as Judged from Skewed Age and Sex Ratios

    PubMed Central

    Møller, Anders Pape; Bonisoli-Alquati, Andrea; Rudolfsen, Geir; Mousseau, Timothy A.

    2012-01-01

    Background Radiation has negative effects on survival of animals including humans, although the generality of this claim is poorly documented under low-dose field conditions. Because females may suffer disproportionately from the effects of radiation on survival due to differences in sex roles during reproduction, radiation-induced mortality may result in male-skewed adult sex ratios. Methodology/Principal Finding We estimated the effects of low-dose radiation on adult survival rates in birds by determining age ratios of adults captured in mist nets during the breeding season in relation to background radiation levels around Chernobyl and in nearby uncontaminated control areas. Age ratios were skewed towards yearlings, especially in the most contaminated areas, implying that adult survival rates were reduced in contaminated areas, and that populations in such areas could only be maintained through immigration from nearby uncontaminated areas. Differential mortality in females resulted in a strongly male-skewed sex ratio in the most contaminated areas. In addition, males sang disproportionately commonly in the most contaminated areas where the sex ratio was male skewed presumably because males had difficulty finding and acquiring mates when females were rare. The results were not caused by permanent emigration by females from the most contaminated areas because none of the recaptured birds had changed breeding site, and the proportion of individuals with morphological abnormalities did not differ significantly between the sexes for areas with normal and higher levels of contamination. Conclusions/Significance These findings are consistent with the hypothesis that the adult survival rate of female birds is particularly susceptible to the effects of low-dose radiation, resulting in male skewed sex ratios at high levels of radiation. Such skewed age ratios towards yearlings in contaminated areas are consistent with the hypothesis that an area exceeding 30,000 km2 in

  15. Strictly ordered minimal subsets of a class of convex monotone skew-product semiflows

    NASA Astrophysics Data System (ADS)

    Novo, Sylvia; Obaya, Rafael

    We study the topological and ergodic structure of a class of convex and monotone skew-product semiflows. We assume the existence of two strongly ordered minimal subsets K 1, K 2 and we obtain an ergodic representation of their upper Lyapunov exponents. In the case of null upper Lyapunov exponents, we obtain a lamination into minimal subsets of an intermediate region where the restriction of the semiflow is affine. In the hyperbolic case, we deduce the long-time behaviour of every trajectory ordered with K2. Some examples of skew-product semiflows generated by non-autonomous differential equations and satisfying the assumptions of monotonicity and convexity are also presented.

  16. Analysis of axially non-uniform loss distribution in 3-phase induction motor considering skew effect

    SciTech Connect

    Kown, B.I.; Kim, B.T.; Jun, C.S.; Park, S.C. )

    1999-05-01

    This paper discusses the phenomena of the axially non-uniform distribution of magnetic flux densities and losses in a 3-phase squirrel cage induction motor of which the rotor bars are skewed. A 2-dimensional complex finite element method taking account of the effects of the skewed rotor bars is utilized for the analysis of characteristics such as copper and iron losses and the loss distributions are examined. The summing up values of non-uniform losses resulted from the finite element analysis are compared with measurement values.

  17. Modified Gelfand-Tseltin patterns, lattice permutations, and skew-tableau polynomials

    SciTech Connect

    Louck, James D.

    2002-01-01

    A modification of the well-known Gelfand-Tsetlin patterns, which are one-to-one with Young-Weyl standard tableaux is introduced. These new patterns are in one-to-one correspondence with skew-tableaux, and with a slight modification can be used to enumerate lattice permutations. In particular the coupling rule for angular momentum takes an elementary form in terms of these modified patterns. These interrelations will be presented, together with an outline of the construction of a class of polynomials that generalizes the skew Schur functions.

  18. Generalized skew coefficient for flood frequency computations for the State of Hawaii

    USGS Publications Warehouse

    Lee, Reuben

    1984-01-01

    In 1976, the Hydrology Committee of the U.S. Water Resources Council estimated a generalized skew coefficient for flood frequency computations of -0.05 for the State of Hawaii. This value is the average of 30 stream gaging stations with 25 or more years of record through water year 1973. This report updates the generalized skew coefficient for the State of Hawaii to -0.14. It is the average of 68 stream gaging stations with 25 or more years of record. (USGS)

  19. Rings of skew polynomials and Gel'fand-Kirillov conjecture for quantum groups

    NASA Astrophysics Data System (ADS)

    Iohara, Kenji; Malikov, Feodor

    1994-08-01

    We introduce and study action of quantum groups on skew polynomial rings and related rings of quotients. This leads to a “ q-deformation” of the Gel'fand-Kirillov conjecture which we partially prove. We propose a construction of automorphisms of certain non-commutative rings of quotients coming from complex powers of quantum group generators; this is applied to explicit calculation of singular vectors in Verma modules overU_q (mathfrak{s}mathfrak{l}_{n + 1} ). We finally give a definition of a q-connection with coefficients in a ring of skew polynomials and study the structure of quantum group modules twisted by a q-connection.

  20. Stability as a Whole of a Family of Fibers Maps and Ω-Stability of C 1-Smooth Skew Products of Maps of an Interval

    NASA Astrophysics Data System (ADS)

    Efremova, Lyudmila S.

    2016-02-01

    Properties of C 1 smooth skew products of maps of an interval with stable as a whole family of fibers maps are established. These results are applied to the proof of the criterion of Ω-stability of C 1-smooth skew products of maps of an interval (with respect to homeomorphisms of skew products class). The proper subspace of the space of C 1smooth skew products of maps of an interval is distinguished, where Ω-stable C 1smooth skew products are contained. It is proved that Ω- stable skew products are not dense in the distinguished subspace of C 1 -smooth maps.

  1. Influence of pressure gradient on streamwise skewness factor in turbulent boundary layer

    NASA Astrophysics Data System (ADS)

    Dróżdż, Artur

    2014-08-01

    The paper shows an effect of favourable and adverse pressure gradients on turbulent boundary layer. The skewness factor of streamwise velocity component was chosen as a measure of the pressure gradient impact. It appears that skewness factor is an indicator of convection velocity of coherent structures, which is not always equal to the average flow velocity. The analysis has been performed based upon velocity profiles measured with hot-wire technique in turbulent boundary layer with pressure gradient corresponding to turbomachinery conditions. The results show that the skewness factor decreases in the flow region subjected to FPG and increases in the APG conditions. The changes of convection velocity and skewness factor are caused by influence of large-scale motion through the mechanism called amplitude modulation. The large-scale motion is less active in FPG and more active in APG, therefore in FPG the production of vortices is random (there are no high and low speed regions), while in the APG the large-scale motion drives the production of vortices. Namely, the vortices appear only in the high-speed regions, therefore have convection velocity higher than local mean velocity. The convection velocity affects directly the turbulent sweep and ejection events. The more flow is dominated by large-scale motion the higher values takes both the convection velocity of small-scale structures and sweep events induced by them.

  2. Bayesian analysis of nonlinear mixed-effects mixture models for longitudinal data with heterogeneity and skewness.

    PubMed

    Lu, Xiaosun; Huang, Yangxin

    2014-07-20

    It is a common practice to analyze complex longitudinal data using nonlinear mixed-effects (NLME) models with normality assumption. The NLME models with normal distributions provide the most popular framework for modeling continuous longitudinal outcomes, assuming individuals are from a homogeneous population and relying on random-effects to accommodate inter-individual variation. However, the following two issues may standout: (i) normality assumption for model errors may cause lack of robustness and subsequently lead to invalid inference and unreasonable estimates, particularly, if the data exhibit skewness and (ii) a homogeneous population assumption may be unrealistically obscuring important features of between-subject and within-subject variations, which may result in unreliable modeling results. There has been relatively few studies concerning longitudinal data with both heterogeneity and skewness features. In the last two decades, the skew distributions have shown beneficial in dealing with asymmetric data in various applications. In this article, our objective is to address the simultaneous impact of both features arisen from longitudinal data by developing a flexible finite mixture of NLME models with skew distributions under Bayesian framework that allows estimates of both model parameters and class membership probabilities for longitudinal data. Simulation studies are conducted to assess the performance of the proposed models and methods, and a real example from an AIDS clinical trial illustrates the methodology by modeling the viral dynamics to compare potential models with different distribution specifications; the analysis results are reported. PMID:24623529

  3. From individual control to majority rule: extending transactional models of reproductive skew in animal societies.

    PubMed Central

    Reeve, Hudson Kern; Jeanne, Robert L

    2003-01-01

    Transactional concession models of social evolution explain the reproductive skew within groups by assuming that a dominant individual completely controls the allocation of reproduction to other group members. The models predict when the dominant will benefit from donating parcels of reproduction to other members in return for peaceful cooperation. Using linear programming methods, we present a 'majority-rules' model in which the summed actions of all society members, each with equal power, completely determine the reproductive share of any single member. The majority-rules model predicts that, despite the diffusion of power, a 'virtual dominant' (a dominant lacking special behavioural power) will emerge and that the reproductive skew will be exactly that predicted if the virtual dominant were to control completely the group's reproductive partitioning. The virtual dominant is the individual to which group members have the maximum average genetic relatedness. This result greatly broadens the applicability of transactional models of reproductive skew to social groups of any size, such as large-colony eusocial insects, and explains why queens in such colonies can achieve reproductive domination without any behavioural enforcement. Moreover, the majority-rules model unifies transactional-skew theory with models of worker policing and even generates a new theory for the cooperation among somatic cells in a multicellular organism. PMID:12803893

  4. Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization.

    PubMed

    Tan, Kun; An, Lei; Miao, Kai; Ren, Likun; Hou, Zhuocheng; Tao, Li; Zhang, Zhenni; Wang, Xiaodong; Xia, Wei; Liu, Jinghao; Wang, Zhuqing; Xi, Guangyin; Gao, Shuai; Sui, Linlin; Zhu, De-Sheng; Wang, Shumin; Wu, Zhonghong; Bach, Ingolf; Chen, Dong-Bao; Tian, Jianhui

    2016-03-22

    Dynamic epigenetic reprogramming occurs during normal embryonic development at the preimplantation stage. Erroneous epigenetic modifications due to environmental perturbations such as manipulation and culture of embryos during in vitro fertilization (IVF) are linked to various short- or long-term consequences. Among these, the skewed sex ratio, an indicator of reproductive hazards, was reported in bovine and porcine embryos and even human IVF newborns. However, since the first case of sex skewing reported in 1991, the underlying mechanisms remain unclear. We reported herein that sex ratio is skewed in mouse IVF offspring, and this was a result of female-biased peri-implantation developmental defects that were originated from impaired imprinted X chromosome inactivation (iXCI) through reduced ring finger protein 12 (Rnf12)/X-inactive specific transcript (Xist) expression. Compensation of impaired iXCI by overexpression ofRnf12to up-regulateXistsignificantly rescued female-biased developmental defects and corrected sex ratio in IVF offspring. Moreover, supplementation of an epigenetic modulator retinoic acid in embryo culture medium up-regulatedRnf12/Xistexpression, improved iXCI, and successfully redeemed the skewed sex ratio to nearly 50% in mouse IVF offspring. Thus, our data show that iXCI is one of the major epigenetic barriers for the developmental competence of female embryos during preimplantation stage, and targeting erroneous epigenetic modifications may provide a potential approach for preventing IVF-associated complications. PMID:26951653

  5. Large-Scale Age-Dependent Skewed Sex Ratio in a Sexually Dimorphic Avian Scavenger

    PubMed Central

    Lambertucci, Sergio A.; Carrete, Martina; Donázar, José Antonio; Hiraldo, Fernando

    2012-01-01

    Age-dependent skewed sex ratios have been observed in bird populations, with adult males generally outnumbering females. This trend is mainly driven by higher female mortality, sometimes associated with anthropogenic factors. Despite the large amount of work on bird sex ratios, research examining the spatial stability of adult sex ratios is extremely scarce. The Andean condor (Vultur gryphus) is the only bird of prey with strong sexual dimorphism favouring males (males are 30% heavier than females). By examining data from most of its South-American range, we show that while the juvenile sex ratio is balanced, or even female-skewed, the sex ratio becomes increasing male-skewed with age, with adult males outnumbering females by >20%, and, in some cases by four times more. This result is consistent across regions and independent of the nature of field data. Reasons for this are unknown but it can be hypothesized that the progressive disappearance of females may be associated with mortality caused by anthropogenic factors. This idea is supported by the asymmetric habitat use by the two sexes, with females scavenging in more humanized areas. Whatever the cause, male-skewed adult sex ratios imply that populations of this endangered scavenger face higher risks of extinction than previously believed. PMID:23029488

  6. Reproductive skew in female common marmosets: what can proximate mechanisms tell us about ultimate causes?

    PubMed Central

    Saltzman, Wendy; Digby, Leslie J.; Abbott, David H.

    2008-01-01

    Common marmosets are cooperatively breeding monkeys that exhibit high reproductive skew: most subordinate females fail to reproduce, while others attempt to breed but produce very few surviving infants. An extensive dataset on the mechanisms limiting reproduction in laboratory-housed and free-living subordinate females provides unique insights into the causes of reproductive skew. Non-breeding adult females undergo suppression of ovulation and inhibition of sexual behaviour; however, they receive little or no aggression or mating interference by dominants and do not exhibit behavioural or physiological signs of stress. Breeding subordinate females receive comparable amounts of aggression to non-breeding females but are able to conceive, gestate and lactate normally. In groups containing two breeding females, however, both dominant and subordinate breeders kill one another's infants. These findings suggest that preconception reproductive suppression is not imposed on subordinate females by dominants, at a proximate level, but is instead self-imposed by most subordinates, consistent with restraint models of reproductive skew. In contrast to restraint models, however, this self-suppression probably evolved not in response to the threat of eviction by dominant females but in response to the threat of infanticide. Thus, reproductive skew in this species appears to be generated predominantly by subordinate self-restraint, in a proximate sense, but ultimately by dominant control over subordinates' reproductive attempts. PMID:18945663

  7. Using social parasitism to test reproductive skew models in a primitively eusocial wasp

    PubMed Central

    Green, Jonathan P.; Cant, Michael A.; Field, Jeremy

    2014-01-01

    Remarkable variation exists in the distribution of reproduction (skew) among members of cooperatively breeding groups, both within and between species. Reproductive skew theory has provided an important framework for understanding this variation. In the primitively eusocial Hymenoptera, two models have been routinely tested: concessions models, which assume complete control of reproduction by a dominant individual, and tug-of-war models, which assume on-going competition among group members over reproduction. Current data provide little support for either model, but uncertainty about the ability of individuals to detect genetic relatedness and difficulties in identifying traits conferring competitive ability mean that the relative importance of concessions versus tug-of-war remains unresolved. Here, we suggest that the use of social parasitism to generate meaningful variation in key social variables represents a valuable opportunity to explore the mechanisms underpinning reproductive skew within the social Hymenoptera. We present a direct test of concessions and tug-of-war models in the paper wasp Polistes dominulus by exploiting pronounced changes in relatedness and power structures that occur following replacement of the dominant by a congeneric social parasite. Comparisons of skew in parasitized and unparasitized colonies are consistent with a tug-of-war over reproduction within P. dominulus groups, but provide no evidence for reproductive concessions. PMID:24990668

  8. The Curious Anomaly of Skewed Judgment Distributions and Systematic Error in the Wisdom of Crowds

    PubMed Central

    Nash, Ulrik W.

    2014-01-01

    Judgment distributions are often skewed and we know little about why. This paper explains the phenomenon of skewed judgment distributions by introducing the augmented quincunx (AQ) model of sequential and probabilistic cue categorization by neurons of judges. In the process of developing inferences about true values, when neurons categorize cues better than chance, and when the particular true value is extreme compared to what is typical and anchored upon, then populations of judges form skewed judgment distributions with high probability. Moreover, the collective error made by these people can be inferred from how skewed their judgment distributions are, and in what direction they tilt. This implies not just that judgment distributions are shaped by cues, but that judgment distributions are cues themselves for the wisdom of crowds. The AQ model also predicts that judgment variance correlates positively with collective error, thereby challenging what is commonly believed about how diversity and collective intelligence relate. Data from 3053 judgment surveys about US macroeconomic variables obtained from the Federal Reserve Bank of Philadelphia and the Wall Street Journal provide strong support, and implications are discussed with reference to three central ideas on collective intelligence, these being Galton's conjecture on the distribution of judgments, Muth's rational expectations hypothesis, and Page's diversity prediction theorem. PMID:25406078

  9. SLOW SHOCKS AND CONDUCTION FRONTS FROM PETSCHEK RECONNECTION OF SKEWED MAGNETIC FIELDS: TWO-FLUID EFFECTS

    SciTech Connect

    Longcope, D. W.; Bradshaw, S. J.

    2010-08-01

    In models of fast magnetic reconnection, flux transfer occurs within a small portion of a current sheet triggering stored magnetic energy to be thermalized by shocks. When the initial current sheet separates magnetic fields which are not perfectly anti-parallel, i.e., they are skewed, magnetic energy is first converted to bulk kinetic energy and then thermalized in slow magnetosonic shocks. We show that the latter resemble parallel shocks or hydrodynamic shocks for all skew angles except those very near the anti-parallel limit. As for parallel shocks, the structures of reconnection-driven slow shocks are best studied using two-fluid equations in which ions and electrons have independent temperature. Time-dependent solutions of these equations can be used to predict and understand the shocks from reconnection of skewed magnetic fields. The results differ from those found using a single-fluid model such as magnetohydrodynamics. In the two-fluid model, electrons are heated indirectly and thus carry a heat flux always well below the free-streaming limit. The viscous stress of the ions is, however, typically near the fluid-treatable limit. We find that for a wide range of skew angles and small plasma {beta} an electron conduction front extends ahead of the slow shock but remains within the outflow jet. In such cases, conduction will play a more limited role in driving chromospheric evaporation than has been predicted based on single-fluid, anti-parallel models.

  10. Bayesian Comparison of GARCH Processes with Skewness Mechanism in Conditional Distributions

    NASA Astrophysics Data System (ADS)

    Pipien, M.

    2006-11-01

    The main goal of this paper is an application of Bayesian model comparison, based on the posterior probabilities and posterior odds ratios, in testing the explanatory power of a set of competing GARCH (Generalized Autoregressive Conditionally Heteroscedastic) specifications, all with asymmetric and heavy tailed conditional distributions. In building competing volatility models we consider, as an initial specification, conditionally Student-t GARCH process with unknown degrees of freedom parameter. By introducing skewness into Student-t family and incorporating the resulting class as a conditional distribution we generated various GARCH models, which compete in explaining possible asymmetry of both conditional and unconditional distribution of financial data. In order to make Student-t family skewed we consider various alternative mechanisms recently proposed in the literature. In particular, we apply the hidden truncation mechanism, an approach based on the inverse scale factors in the positive and the negative orthant, order statistics concept, Beta distribution transformation and Bernstein density transformation. Additionally, we consider GARCH process with conditional alpha -Stable distribution. Based on the daily returns of hypothetical financial time series, we discuss the results of Bayesian comparison of alternative skewing mechanisms applied in the initial Student-t GARCH framework. Additionally, we present formal Bayesian inference about conditional asymmetry of the distribution of the daily returns in all competing specifications on the basis of the skewness measure defined by Arnold and Groenveld.

  11. An analytical algorithm for skew-slit imaging geometry with nonuniform attenuation correction

    SciTech Connect

    Huang Qiu; Zeng, Gengsheng L.

    2006-04-15

    The pinhole collimator is currently the collimator of choice in small animal single photon emission computed tomography (SPECT) imaging because it can provide high spatial resolution and reasonable sensitivity when the animal is placed very close to the pinhole. It is well known that if the collimator rotates around the object (e.g., a small animal) in a circular orbit to form a cone-beam imaging geometry with a planar trajectory, the acquired data are not sufficient for an exact artifact-free image reconstruction. In this paper a novel skew-slit collimator is mounted instead of the pinhole collimator in order to significantly reduce the image artifacts caused by the geometry. The skew-slit imaging geometry is a more generalized version of the pinhole imaging geometry. The multiple pinhole geometry can also be extended to the multiple-skew-slit geometry. An analytical algorithm for image reconstruction based on the tilted fan-beam inversion is developed with nonuniform attenuation compensation. Numerical simulation shows that the axial artifacts are evidently suppressed in the skew-slit images compared to the pinhole images and the attenuation correction is effective.

  12. On the rotation and skew-symmetric forms for incompressible flow simulations

    NASA Technical Reports Server (NTRS)

    Zang, Thomas A.

    1991-01-01

    A variety of numerical simulations of transition and turbulence in incompressible flow are presented to compare the commonly used rotation form with the skew-symmetric (and other) forms of the nonlinear terms. The results indicate that the rotation form is much less accurate than the other forms for spectral algorithms which include aliasing errors. For de-aliased methods the difference is minimal.

  13. A Monte Carlo Study of Skewed Theta Distributions on DIF Indices.

    ERIC Educational Resources Information Center

    Monaco, Malina

    The effects of skewed theta distributions on indices of differential item functioning (DIF) were studied, comparing Mantel Haenszel (N. Mantel and W. Haenszel, 1959) and DFIT (N. S. Raju, W. J. van der Linden, and P. F. Fleer) (noncompensatory DIF). The significance of the study is that in educational and psychological data, the distributions one…

  14. Biased Decision-Making: Developing an Understanding of How Positive and Negative Relationships May Skew Judgments

    ERIC Educational Resources Information Center

    Mills, Candice M.; Grant, Meridith G.

    2009-01-01

    The current experiment examines if and when children consider the possibility of relationships skewing judgments when evaluating judgments in different contexts. Eighty-seven 6-year-olds, 8-year-olds, 10-year-olds, and adults heard stories about judges who made decisions matching or mismatching possible relationship biases (e.g. a judge choosing a…

  15. Skewing (n +1) Tensor Indices where the Index Range is n

    ERIC Educational Resources Information Center

    Agacy, R. L.

    2005-01-01

    It is known that any totally skew quantity with (n + 1) indices, each of which ranges over n values, vanishes identically. The aim of this short note is to show that this is equivalent to the simple fact that any (n + 1) vectors in an n-dimensional vector space are linearly dependent.

  16. On Some Confidence Intervals for Estimating the Mean of a Skewed Population

    ERIC Educational Resources Information Center

    Shi, W.; Kibria, B. M. Golam

    2007-01-01

    A number of methods are available in the literature to measure confidence intervals. Here, confidence intervals for estimating the population mean of a skewed distribution are considered. This note proposes two alternative confidence intervals, namely, Median t and Mad t, which are simple adjustments to the Student's t confidence interval. In…

  17. Skew angle effects in shingled magnetic recording system with double/triple reader head array

    NASA Astrophysics Data System (ADS)

    Elidrissi, Moulay Rachid; Sann Chan, Kheong; Greaves, Simon; Kanai, Yasushi; Muraoka, Hiroaki

    2014-05-01

    Shingled Magnetic Recording (SMR) is a scheme used to extend the life of the current perpendicular magnetic recording technology. SMR enables writing narrow tracks with a wide writer. Currently, SMR employs a single reader and will suffer inter-track interference (ITI) as the tracks become comparable in width to the reader. ITI can be mitigated by using narrower readers; however, narrower readers suffer from increased reader noise. Another approach to combat ITI is to process 2D readback and use ITI cancellation schemes to retrieve the data track. Multiple readbacks can be obtained either with a single reader and multiple revolutions or with a reader array. The former suffers from increased readback latency. In this work, we focus on the latter. When using a reader array, the skew angle poses major challenges. During writing, there is increased adjacent track erasure, and during readback the effective reader pitch varies and there is an increase in the 2D intersymbol interference caused by the rotated reader profile. In this work, we run micromagnetic simulations at different skew angles to train the grain flipping probability model, and then evaluate raw bit channel error rate performance at skew. In particular, we investigate the performance degradation caused by skewing of the 2 or 3 read head array for various read-head geometries.

  18. Detection and alignment of dual-polarization optical quadrature amplitude transmitter IQ and XY skews using reconfigurable interference.

    PubMed

    Yue, Yang; Zhang, Bo; Wang, Qiang; Lofland, Rob; O'Neil, Jason; Anderson, Jon

    2016-03-21

    Dual-polarization quadrature amplitude modulation (DP-QAM) is one of the feasible paths towards 100-Gb/s, 400-Gb/s and 1-Tb/s optical fiber communications systems. For DP-QAM transmitter, the time mismatch between the in-phase and quadrature (IQ) or x-polarized and y-polarized (XY) tributary channels is known as the IQ or XY skew. Large uncompensated IQ or XY skew can significantly degrade the optical fiber communications system performance. Sometimes, time-interleaved return-to-zero (RZ) DP signal is preferred with lower nonlinear polarization scattering induced penalty. In this work, detection and alignment of DP-QAM transmitter IQ and XY skews using reconfigurable interference is experimentally demonstrated. For IQ skew detection, a total dynamic range of 26.4 dB is achieved with ~1-dB power change for 0.5-ps skew from well alignment. For XY skew detection, it shows 23.2-dB dynamic range, and ~1.5-dB power change is achieved for 1-ps XY skew. Fast detection algorithm for arbitrary skew is also proposed and experimentally verified. The scheme is compatible with different modulation formats, flexible data sequences, and variable waveforms. PMID:27136859

  19. Experimental verification and analytical approach to influence stator skew on electromagnetic performance of permanent magnet generators with multipole rotor

    NASA Astrophysics Data System (ADS)

    Choi, Jang-Young; Jang, Seok-Myeong; Ko, Kyoung-Jin

    2009-04-01

    This paper deals with experimental verification and analytical approach to influence stator skew on electromagnetic performance of a permanent magnet generator (PMG) with multipole rotor. The analytical expressions for magnetic field distributions are due to permanent magnets and the two-dimensional permeance function considering skew effects are established. On the basis of these analytical solutions, the analytical solutions for cogging torque and back-emf considering skew effects are also derived. Then, by applying estimated electrical parameters to a simple equivalent circuit of one phase for the PMG, output performances of the PMG with/without a skewed stator are investigated. Finally, by confirming that all analytical results are validated extensively by nonlinear finite element calculations and measurements, the validity of analysis methods presented in this paper is verified, and the influence stator skew on cogging torque, back-emf, and output performances of the PMG is also clearly described.

  20. Risk-sensitive foraging and the evolution of cooperative breeding and reproductive skew

    PubMed Central

    Poethke, Hans J; Liebig, Jürgen

    2008-01-01

    Background Group formation and food sharing in animals may reduce variance in resource supply to breeding individuals. For some species it has thus been interpreted as a mechanism of risk avoidance. However, in many groups reproduction is extremely skewed. In such groups resources are not shared equally among the members and inter-individual variance in resource supply may be extreme. The potential consequences of this aspect of group living have not attained much attention in the context of risk sensitive foraging. Results We develop a model of individually foraging animals that share resources for reproduction. The model allows analyzing how mean foraging success, inter-individual variance of foraging success, and the cost of reproduction and offspring raising influence the benefit of group formation and resource sharing. Our model shows that the effects are diametrically opposed in egalitarian groups versus groups with high reproductive skew. For individuals in egalitarian groups the relative benefit of group formation increases under conditions of increasing variance in foraging success and decreasing cost of reproduction. On the other hand individuals in groups with high skew will profit from group formation under conditions of decreasing variance in individual foraging success and increasing cost of reproduction. Conclusion The model clearly demonstrates that reproductive skew qualitatively changes the influence of food sharing on the reproductive output of groups. It shows that the individual benefits of variance reduction in egalitarian groups and variance enhancement in groups with reproductive skew depend critically on ecological and life-history parameters. Our model of risk-sensitive foraging thus allows comparing animal societies as different as spiders and birds in a single framework. PMID:18366668

  1. Analysis of gamma-ray burst duration distribution using mixtures of skewed distributions

    NASA Astrophysics Data System (ADS)

    Tarnopolski, M.

    2016-05-01

    Two classes of gamma-ray bursts (GRBs) have been confidently identified thus far and are prescribed to different physical scenarios - neutron star-neutron star or neutron star-black hole mergers, and collapse of massive stars, for short and long GRBs, respectively. A third, intermediate in duration class, was suggested to be present in previous catalogues, such as Burst Alert and Transient Source Explorer (BATSE) and Swift, based on statistical tests regarding a mixture of two or three lognormal distributions of T90. However, this might possibly not be an adequate model. This paper investigates whether the distributions of log T90 from BATSE, Swift, and Fermi are described better by a mixture of skewed distributions rather than standard Gaussians. Mixtures of standard normal, skew-normal, sinh-arcsinh and alpha-skew-normal distributions are fitted using a maximum likelihood method. The preferred model is chosen based on the Akaike information criterion. It is found that mixtures of two skew-normal or two sinh-arcsinh distributions are more likely to describe the observed duration distribution of Fermi than a mixture of three standard Gaussians, and that mixtures of two sinh-arcsinh or two skew-normal distributions are models competing with the conventional three-Gaussian in the case of BATSE and Swift. Based on statistical reasoning, and it is shown that other phenomenological models may describe the observed Fermi, BATSE, and Swift duration distributions at least as well as a mixture of standard normal distributions, and the existence of a third (intermediate) class of GRBs in Fermi data is rejected.

  2. Construction engineering of steel tub-girder bridge systems for skew effects

    NASA Astrophysics Data System (ADS)

    Jimenez Chong, Juan Manuel

    Closed structural sections, such as those having circular, rectangular or trapezoidal shape, possess high rotational rigidity when compared to open sections such as I-girders. The high torsional rigidity of closed sections makes them ideal for use in highly curved bridges. In this case, the geometry of the bridge results in large torsional forces. Because of structural efficiency and economy reasons, most of these closed-section bridges consist of a trapezoidal cross-section, with a top concrete slab and bottom and side steel plates. The slab is cast after the steel is erected and thus a system of internal diaphragms and braces is necessary to stabilize the system during erection. During the steel erection and the early stages of the concrete deck placement, the section can be considered as quasi-closed as the top concrete flange has not been cast or is not yet effective. During steel erection, undetermined and/or large torsional forces and/or displacements may result in fit-up problems requiring large stresses to overcome. During concrete deck placement, the undetermined displacements can affect the control of the deck thickness and the final deck geometry, such as the alignment of deck joints and the matching of stages in phased constructions projects. Due to the interactions between their various components, the behavior of curved and skewed tub-girder bridges is significantly more complex than that of straight bridges. When skewed supports are used in tub-girders, the interaction of the girder bending rotations and the displacement constraints induced by the skewed support diaphragms causes twisting of the girders at the supports. These twist rotations introduce additional torques into the system. Both curvature and skew can cause design and construction difficulties, especially at the supports, where the corresponding steel dead load deflections and the large torsional stiffness of the girders may lead to large fit-up forces. Currently, the general

  3. Olfactory learning skews mushroom body output pathways to steer behavioral choice in Drosophila

    PubMed Central

    Owald, David; Waddell, Scott

    2015-01-01

    Learning permits animals to attach meaning and context to sensory stimuli. How this information is coded in neural networks in the brain, and appropriately retrieved and utilized to guide behavior, is poorly understood. In the fruit fly olfactory memories of particular value are represented within sparse populations of odor-activated Kenyon cells (KCs) in the mushroom body ensemble. During learning reinforcing dopaminergic neurons skew the mushroom body network by driving zonally restricted plasticity at synaptic junctions between the KCs and subsets of the overall small collection of mushroom body output neurons. Reactivation of this skewed KC-output neuron network retrieves memory of odor valence and guides appropriate approach or avoidance behavior. PMID:26496148

  4. Truck loading positions for maximum live load girder moment in skewed integral bridges

    NASA Astrophysics Data System (ADS)

    Yalcin, O. Fatih

    2015-12-01

    In this study, the effect of the longitudinal and transverse truck positions on the distribution of live load moment among the girders of skewed integral abutment bridges (SIBs) is investigated. For this purpose, three dimensional finite element models (FEMs) of several single-span SIBs are built and analyzed. In the analyses, bridges with various skew angles under all possible single and double truck loading positions both in longitudinal and transverse directions are considered. An automated analysis procedure managed by a visual basic program is developed to obtain the structural models and apply the wheel loads of trucks. The finite element analyses (FEA) results are then used to find the most critical loading cases of single truck and adjacent two trucks for the live load moment in the girders of SIBs. The results revealed that, the trucks should be placed nearby the midline of the bridge deck in a diagonal manner.

  5. Skewed X-chromosome inactivation in women affected by Alzheimer's disease.

    PubMed

    Bajic, Vladan; Mandusic, Vesna; Stefanova, Elka; Bozovic, Ana; Davidovic, Radoslav; Zivkovic, Lada; Cabarkapa, Andrea; Spremo-Potparevic, Biljana

    2015-01-01

    X-chromosome instability has been a long established feature in Alzheimer's disease (AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, "Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes of women affected by AD?" To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes of women with AD. Our results showed skewed inactivation patterns (>90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women. PMID:25159673

  6. Optimization Of Mean-Semivariance-Skewness Portfolio Selection Model In Fuzzy Random Environment

    NASA Astrophysics Data System (ADS)

    Chatterjee, Amitava; Bhattacharyya, Rupak; Mukherjee, Supratim; Kar, Samarjit

    2010-10-01

    The purpose of the paper is to construct a mean-semivariance-skewness portfolio selection model in fuzzy random environment. The objective is to maximize the skewness with predefined maximum risk tolerance and minimum expected return. Here the security returns in the objectives and constraints are assumed to be fuzzy random variables in nature and then the vagueness of the fuzzy random variables in the objectives and constraints are transformed into fuzzy variables which are similar to trapezoidal numbers. The newly formed fuzzy model is then converted into a deterministic optimization model. The feasibility and effectiveness of the proposed method is verified by numerical example extracted from Bombay Stock Exchange (BSE). The exact parameters of fuzzy membership function and probability density function are obtained through fuzzy random simulating the past dates.

  7. Maneuver planning of a rigid spacecraft with two skew control moment gyros

    NASA Astrophysics Data System (ADS)

    Gui, Haichao; Jin, Lei; Xu, Shijie

    2014-11-01

    The attitude maneuver planning of a rigid spacecraft using two skew single-gimbal control moment gyros (CMGs) is investigated. First, two types of restrictions are enforced on the gimbal motions of two skew CMGs, with each restriction yielding continuous control torque along a principal axis of the spacecraft. Then, it is proved that any axis fixed to the spacecraft can be pointed along an arbitrary inertial direction by at most two sequent rotations around the two actuated axes. Given this fact, a two-step eigenaxis rotation strategy, executing by the two single-axis torques respectively, is designed to point a given body-fixed axis along a desired direction. Furthermore, a three-step eigenaxis rotation strategy is constructed to achieve an arbitrary rest-to-rest attitude maneuver. The rotation angles required for the single-axis pointing and arbitrary attitude maneuver schemes are all analytically solved. Numerical examples are presented to demonstrate the effectiveness of the proposed algorithms.

  8. Muon Tracking Studies in a Skew Parametric Resonance Ionization Cooling Channel

    SciTech Connect

    Sy, Amy; Afanaciev, Andre; Derbenev, Yaroslav S.; Johnson, Rolland; Morozov, Vasiliy

    2015-09-01

    Skew Parametric-resonance Ionization Cooling (SPIC) is an extension of the Parametric-resonance Ionization Cooling (PIC) framework that has previously been explored as the final 6D cooling stage of a high-luminosity muon collider. The addition of skew quadrupoles to the PIC magnetic focusing channel induces coupled dynamic behavior of the beam that is radially periodic. The periodicity of the radial motion allows for the avoidance of unwanted resonances in the horizontal and vertical transverse planes, while still providing periodic locations at which ionization cooling components can be implemented. A first practical implementation of the magnetic field components required in the SPIC channel is modeled in MADX. Dynamic features of the coupled correlated optics with and without induced parametric resonance are presented and discussed.

  9. Skew-Quad Parametric-Resonance Ionization Cooling: Theory and Modeling

    SciTech Connect

    Afanaciev, Andre; Derbenev, Yaroslav S.; Morozov, Vasiliy; Sy, Amy; Johnson, Rolland P.

    2015-09-01

    Muon beam ionization cooling is a key component for the next generation of high-luminosity muon colliders. To reach adequately high luminosity without excessively large muon intensities, it was proposed previously to combine ionization cooling with techniques using a parametric resonance (PIC). Practical implementation of PIC proposal is a subject of this report. We show that an addition of skew quadrupoles to a planar PIC channel gives enough flexibility in the design to avoid unwanted resonances, while meeting the requirements of radially-periodic beam focusing at ionization-cooling plates, large dynamic aperture and an oscillating dispersion needed for aberration corrections. Theoretical arguments are corroborated with models and a detailed numerical analysis, providing step-by-step guidance for the design of Skew-quad PIC (SPIC) beamline.

  10. Semiparametric Bayesian inference on skew-normal joint modeling of multivariate longitudinal and survival data.

    PubMed

    Tang, An-Min; Tang, Nian-Sheng

    2015-02-28

    We propose a semiparametric multivariate skew-normal joint model for multivariate longitudinal and multivariate survival data. One main feature of the posited model is that we relax the commonly used normality assumption for random effects and within-subject error by using a centered Dirichlet process prior to specify the random effects distribution and using a multivariate skew-normal distribution to specify the within-subject error distribution and model trajectory functions of longitudinal responses semiparametrically. A Bayesian approach is proposed to simultaneously obtain Bayesian estimates of unknown parameters, random effects and nonparametric functions by combining the Gibbs sampler and the Metropolis-Hastings algorithm. Particularly, a Bayesian local influence approach is developed to assess the effect of minor perturbations to within-subject measurement error and random effects. Several simulation studies and an example are presented to illustrate the proposed methodologies. PMID:25404574

  11. Commutative n-ary superalgebras with an invariant skew-symmetric form

    NASA Astrophysics Data System (ADS)

    Vishnyakova, E. G.

    2015-12-01

    We study n-ary commutative superalgebras and L∞-algebras that possess a skew-symmetric invariant form, using the derived bracket formalism. This class of superalgebras includes for instance Lie algebras and their n-ary generalizations, commutative associative and Jordan algebras with an invariant form. We give a classification of anti-commutative m-dimensional (m - 3) -ary algebras with an invariant form, and a classification of real simple m-dimensional Lie (m - 3) -algebras with a positive definite invariant form up to isometry. Furthermore, we develop the Hodge Theory for L∞-algebras with a symmetric invariant form, and we describe quasi-Frobenius structures on skew-symmetric n-ary algebras.

  12. Streamwise vortex production by pitched and skewed jets in a turbulent boundary layer

    NASA Astrophysics Data System (ADS)

    Compton, Debora A.; Johnston, James P.

    1991-01-01

    Weak longitudinal (streamwise) vortices produced by the interaction of simple round wall jets with a two-dimensional flow comprising a turbulent boundary layer were studied experimentally. Like the jets used in the Vortex Generator Jet (VGJ) method of stall control by Johnston and Nushi (1989), the jets in this study were pitched up at 45 degrees and skewed relative to the free stream as they entered from the wall. Skew angles of 90 to 45 degrees produced the strongest vortices, and vortex strength increased with jet speed over the range studied, VR = U(j)U(infinity) = 0.7 to 1.3. It is shown that the vortices produced by the jets are significantly different from those produced by a solid vortex generator, despite the fact that both types have proven effective in enhancement of mixing across a separated or separating turbulent boundary layer.

  13. NGC 3124: A Resonance Ring Disk Galaxy with a Skewed Bar

    NASA Astrophysics Data System (ADS)

    Treuthardt, P.; Seigar, M. S.; Salo, H.; Kennefick, D.; Kennefick, J.; Lacy, C. H. S.

    2014-03-01

    NGC 3124 is a highly regular SB(r)bc galaxy harboring a skewed bar that appears to be a very open spiral, counter-winding relative to the outer spiral arms. We investigate whether such bar morphology can be due to secular processes or if a more violent interaction is necessary. We find that the dust morphology observed in the bar region has the same sense of winding as the outer spiral arms. We also find that the gas kinematics are consistent across the galaxy. Finally, we attempt to recreate the observed stellar morphology by simulating the behavior of a large number of stellar test particles in a rigidly rotating gravitational potential. We are able to reproduce the skewed stellar bar but find that it is transient in nature. This evidence is a strong indication that secular processes are responsible for this unusual bar morphology.

  14. Surveying and optical tooling technologies combined to align a skewed beamline at the LAMPF accelerator

    SciTech Connect

    Bauke, W.; Clark, D.A.; Trujillo, P.B.

    1985-01-01

    Optical Tooling evolved from traditional surveying, and both technologies are sometimes used interchangeably in large industrial installations, since the instruments and their specialized adapters and supports complement each other well. A unique marriage of both technologies was accomplished in a novel application at LAMPF, the Los Alamos Meson Physics Facility. LAMPF consists of a linear accelerator with multiple target systems, one of which had to be altered to accommodate a new beamline for a neutrino experiment. The new line was to be installed into a crowded beam tunnel and had to be skewed and tilted in compound angles to avoid existing equipment. In this paper we describe how Optical Tooling was used in conjunction with simple alignment and reference fixtures to set fiducials on the magnets and other mechanical components of the beamline, and how theodolites and sight levels were then adapted to align these components along the calculated skew planes. Design tolerances are compared with measured alignment results.

  15. Permanent Magnet Skew Quadrupoles for the Low Emittance LER Lattice of PEP-II

    SciTech Connect

    Decker, F.-J.; Anderson, S.; Kharakh, D.; Sullivan, M.; /SLAC

    2011-07-05

    The vertical emittance of the low energy ring (LER) in the PEP-II B-Factory was reduced by using skew quadrupoles consisting of permanent magnet material. The advantages over electric quadrupoles or rotating existing normal quadrupoles are discussed. To assure a high field quality, a Biot-Savart calculation was used to cancel the natural 12-pole component by using different size poles over a few layers. A magnetic measurement confirmed the high quality of the magnets. After installation and adjusting the original electric 12 skew and 16 normal quadrupoles the emittance contribution from the region close to the interaction point, which was the biggest part in the original design, was considerably reduced. To strengthen the vertical behavior of the LER beam, a low emittance lattice was developed. It lowered the original vertical design emittance from 0.54 nm-rad to 0.034 nm-rad. In order to achieve this, additional skew quadrupoles were required to bring the coupling correction out of the arcs and closer to the detector solenoid in the straight (Fig. 1). It is important, together with low vertical dispersion, that the low vertical emittance is not coupled into the horizontal, which is what we get if the coupling correction continues into the arcs. Further details of the lattice work is described in another paper; here we concentrate on the development of the permanent skew (PSK) quadrupole solution. Besides the permanent magnets there are two other possibilities, using electric magnets or rotating normal quadrupoles. Electric magnets would have required much more additional equipment like magnets stands, power supply, and new vacuum chamber sections. Rotating existing quadrupoles was also not feasible since they are mostly mounted together with a bending magnet on the same support girder.

  16. Detection of microscopic defects in optical fiber coatings using angle-resolved skew rays.

    PubMed

    Chen, George Y; Monro, Tanya M; Lancaster, David G

    2016-09-01

    Microscopic defects in optical fiber coatings can be an impending catastrophe for high-power fiber laser and telecommunications systems and are difficult to detect with conventional methods. We demonstrate a highly sensitive interrogation technique that can readily identify faults such as microscopic nicks, scrapes, low-quality recoatings, and internal defects in fibers and their coatings, based on skew ray excitation and angle-resolved analysis. PMID:27607966

  17. Skewness-induced asymmetric modulation of small-scale turbulence by large-scale structures

    NASA Astrophysics Data System (ADS)

    Agostini, Lionel; Leschziner, Michael; Gaitonde, Datta

    2016-01-01

    Several recent studies discuss of role of skewness of the turbulent velocity fluctuations in near-wall shear layers, in the context of quantifying the correlation between large-scale motions and amplitude variations of small-scale fluctuations—referred to as "modulation." The present study is based on the premise that the skewness of the small-scale fluctuations should be accounted for explicitly in the process of defining their envelope, which characterizes their amplitude variations. This leads to the notion of two envelopes, one for positive and the other for negative small-scale fluctuations, and hence also to two corresponding correlation coefficients. Justification for this concept is provided first by an examination of a high-frequency synthetic signal subjected to realistic skewness-inducing modulation. A new formalism is provided for deriving the two envelopes, and its fidelity is demonstrated for the synthetic test case. The method is then applied to a channel flow at a friction Reynolds number of 4200, for which direct numerical simulation (DNS) data are available. The large-scale and small-scale fields are separated by the empirical mode decomposition method, and the modulation of the small-scale fluctuations by the large scales is examined. Separate maps of the correlation coefficient and of two-point correlations, the latter linking the large-scale motions and the envelopes of the small-scale motions, are derived for the two envelopes pertaining to positive and negative small-scale fluctuations, and these demonstrate a significant sensitivity to the envelope-definition process, especially close to the wall where the skewness of the small-scale fluctuations is the dominant contributor to the total value.

  18. Measuring skewness of red blood cell deformability distribution by laser ektacytometry

    SciTech Connect

    Nikitin, S Yu; Priezzhev, A V; Lugovtsov, A E; Ustinov, V D

    2014-08-31

    An algorithm is proposed for measuring the parameters of red blood cell deformability distribution based on laser diffractometry of red blood cells in shear flow (ektacytometry). The algorithm is tested on specially prepared samples of rat blood. In these experiments we succeeded in measuring the mean deformability, deformability variance and skewness of red blood cell deformability distribution with errors of 10%, 15% and 35%, respectively. (laser biophotonics)

  19. Quantum integrable systems, non-skew-symmetric r-matrices and algebraic Bethe ansatz

    SciTech Connect

    Skrypnyk, T.

    2007-02-15

    We prove the integrability of the general quantum Hamiltonian systems governed by an arbitrary non-skew-symmetric, so(3)-valued, nondynamical classical r-matrix with spectral parameters. We consider the most interesting example of these quantum integrable systems, namely, the so(3) 'generalized Gaudin systems' in detail. In the case of an arbitrary r-matrix which is 'diagonal' in the sl(2) basis we calculate the spectrum and the eigenvalues of the corresponding Hamiltonians using the algebraic Bethe ansatz technique.

  20. Effects of Trophic Skewing of Species Richness on Ecosystem Functioning in a Diverse Marine Community

    PubMed Central

    Reynolds, Pamela L.; Bruno, John F.

    2012-01-01

    Widespread overharvesting of top consumers of the world’s ecosystems has “skewed” food webs, in terms of biomass and species richness, towards a generally greater domination at lower trophic levels. This skewing is exacerbated in locations where exotic species are predominantly low-trophic level consumers such as benthic macrophytes, detritivores, and filter feeders. However, in some systems where numerous exotic predators have been added, sometimes purposefully as in many freshwater systems, food webs are skewed in the opposite direction toward consumer dominance. Little is known about how such modifications to food web topology, e.g., changes in the ratio of predator to prey species richness, affect ecosystem functioning. We experimentally measured the effects of trophic skew on production in an estuarine food web by manipulating ratios of species richness across three trophic levels in experimental mesocosms. After 24 days, increasing macroalgal richness promoted both plant biomass and grazer abundance, although the positive effect on plant biomass disappeared in the presence of grazers. The strongest trophic cascade on the experimentally stocked macroalgae emerged in communities with a greater ratio of prey to predator richness (bottom-rich food webs), while stronger cascades on the accumulation of naturally colonizing algae (primarily microalgae with some early successional macroalgae that recruited and grew in the mesocosms) generally emerged in communities with greater predator to prey richness (the more top-rich food webs). These results suggest that trophic skewing of species richness and overall changes in food web topology can influence marine community structure and food web dynamics in complex ways, emphasizing the need for multitrophic approaches to understand the consequences of marine extinctions and invasions. PMID:22693549

  1. Effect of phase response curve skew on synchronization with and without conduction delays.

    PubMed

    Canavier, Carmen C; Wang, Shuoguo; Chandrasekaran, Lakshmi

    2013-01-01

    A central problem in cortical processing including sensory binding and attentional gating is how neurons can synchronize their responses with zero or near-zero time lag. For a spontaneously firing neuron, an input from another neuron can delay or advance the next spike by different amounts depending upon the timing of the input relative to the previous spike. This information constitutes the phase response curve (PRC). We present a simple graphical method for determining the effect of PRC shape on synchronization tendencies and illustrate it using type 1 PRCs, which consist entirely of advances (delays) in response to excitation (inhibition). We obtained the following generic solutions for type 1 PRCs, which include the pulse-coupled leaky integrate and fire model. For pairs with mutual excitation, exact synchrony can be stable for strong coupling because of the stabilizing effect of the causal limit region of the PRC in which an input triggers a spike immediately upon arrival. However, synchrony is unstable for short delays, because delayed inputs arrive during a refractory period and cannot trigger an immediate spike. Right skew destabilizes antiphase and enables modes with time lags that grow as the conduction delay is increased. Therefore, right skew favors near synchrony at short conduction delays and a gradual transition between synchrony and antiphase for pairs coupled by mutual excitation. For pairs with mutual inhibition, zero time lag synchrony is stable for conduction delays ranging from zero to a substantial fraction of the period for pairs. However, for right skew there is a preferred antiphase mode at short delays. In contrast to mutual excitation, left skew destabilizes antiphase for mutual inhibition so that synchrony dominates at short delays as well. These pairwise synchronization tendencies constrain the synchronization properties of neurons embedded in larger networks. PMID:24376399

  2. Joint Skewness and Its Application in Unsupervised Band Selection for Small Target Detection

    NASA Astrophysics Data System (ADS)

    Geng, Xiurui; Sun, Kang; Ji, Luyan; Tang, Hairong; Zhao, Yongchao

    2015-04-01

    Few band selection methods are specially designed for small target detection. It is well known that the information of small targets is most likely contained in non-Gaussian bands, where small targets are more easily separated from the background. On the other hand, correlation of band set also plays an important role in the small target detection. When the selected bands are highly correlated, it will be unbeneficial for the subsequent detection. However, the existing non-Gaussianity-based band selection methods have not taken the correlation of bands into account, which generally result in high correlation of obtained bands. In this paper, combining the third-order (third-order tensor) and second-order (correlation) statistics of bands, we define a new concept, named joint skewness, for multivariate data. Moreover, we also propose an easy-to-implement approach to estimate this index based on high-order singular value decomposition (HOSVD). Based on the definition of joint skewness, we present an unsupervised band selection for small target detection for hyperspectral data, named joint skewness band selection (JSBS). The evaluation results demonstrate that the bands selected by JSBS are very effective in terms of small target detection.

  3. An Inconvenient Sea Truth: Spread, Steepness, and Skewness of Surface Slopes

    NASA Astrophysics Data System (ADS)

    Munk, Walter

    2009-01-01

    Bréon and Henriot (BH) have collected eight million globally distributed satellite images of sunglitter, which yield a few simple, robust rules about the statistics of surface slopes: 1) constant angular spread, 2) linear steepness, and 3) sigmoid (near stepwise) skewness (all with respect to wind speed). Yet the information is sparse because it says nothing about time and space scales. The BH rules are an inconvenient sea truth, too fundamental to be ignored, too incomplete to be understood. With regard to BH rule 1 (BH:1), I suggest that the constant spread is associated with a wake-like geometry of the short gravities. Steepness linearity (BH:2) remains an enigma. Skewness (BH:3) appears to be correlated with a rather sudden onset of breaking for winds above 4 m s-1. I do not think that skewness comes from parasitic capillaries. These are tentative conclusions; I look forward to intensive sea-going experiments over the next few years demolishing the proposed interpretations.

  4. An inconvenient sea truth: spread, steepness, and skewness of surface slopes.

    PubMed

    Munk, Walter

    2009-01-01

    Bréon and Henriot (BH) have collected eight million globally distributed satellite images of sunglitter, which yield a few simple, robust rules about the statistics of surface slopes: 1) constant angular spread, 2) linear steepness, and 3) sigmoid (near stepwise) skewness (all with respect to wind speed). Yet the information is sparse because it says nothing about time and space scales. The BH rules are an inconvenient sea truth, too fundamental to be ignored, too incomplete to be understood. With regard to BH rule 1 (BH:1), I suggest that the constant spread is associated with a wake-like geometry of the short gravities. Steepness linearity (BH:2) remains an enigma. Skewness (BH:3) appears to be correlated with a rather sudden onset of breaking for winds above 4 m s(-1). I do not think that skewness comes from parasitic capillaries. These are tentative conclusions; I look forward to intensive sea-going experiments over the next few years demolishing the proposed interpretations. PMID:21141042

  5. TVD differencing on three-dimensional unstructured meshes with monotonicity-preserving correction of mesh skewness

    NASA Astrophysics Data System (ADS)

    Denner, Fabian; van Wachem, Berend G. M.

    2015-10-01

    Total variation diminishing (TVD) schemes are a widely applied group of monotonicity-preserving advection differencing schemes for partial differential equations in numerical heat transfer and computational fluid dynamics. These schemes are typically designed for one-dimensional problems or multidimensional problems on structured equidistant quadrilateral meshes. Practical applications, however, often involve complex geometries that cannot be represented by Cartesian meshes and, therefore, necessitate the application of unstructured meshes, which require a more sophisticated discretisation to account for their additional topological complexity. In principle, TVD schemes are applicable to unstructured meshes, however, not all the data required for TVD differencing is readily available on unstructured meshes, and the solution suffers from considerable numerical diffusion as a result of mesh skewness. In this article we analyse TVD differencing on unstructured three-dimensional meshes, focusing on the non-linearity of TVD differencing and the extrapolation of the virtual upwind node. Furthermore, we propose a novel monotonicity-preserving correction method for TVD schemes that significantly reduces numerical diffusion caused by mesh skewness. The presented numerical experiments demonstrate the importance of accounting for the non-linearity introduced by TVD differencing and of imposing carefully chosen limits on the extrapolated virtual upwind node, as well as the efficacy of the proposed method to correct mesh skewness.

  6. Free vibration of composite skewed cylindrical shell panel by finite element method

    NASA Astrophysics Data System (ADS)

    Haldar, Salil

    2008-03-01

    In this paper a composite triangular shallow shell element has been used for free vibration analysis of laminated composite skewed cylindrical shell panels. In the present element first-order shear deformation theory has been incorporated by taking transverse displacement and bending rotations as independent field variables. The interpolation function used to approximate transverse displacement is one order higher than for bending rotations. This has made the element free from locking in shear. Two types of mass lumping schemes have been recommended. In one of the mass lumping scheme the effect of rotary inertia has been incorporated in the element formulations. Free vibration of skewed composite cylindrical shell panels having different thickness to radius ratios ( h/R=0.01-0.2), length to radius ratios ( L/R), number of layers and fiber orientation angles have been analyzed following the shallow shell method. The results for few examples obtained in the present analysis have compared with the published results. Some new results of composite skewed cylindrical shell panels have been presented which are expected to be useful to future research in this direction.

  7. Measurement of primordial non-Gaussianity using the WMAP 5-year temperature skewness power spectrum

    SciTech Connect

    Smidt, Joseph; Amblard, Alexandre; Serra, Paolo; Cooray, Asantha

    2009-12-15

    We constrain the primordial non-Gaussianity parameter of the local model f{sub NL} using the skewness power spectrum associated with the two-to-one cumulant correlator of cosmic microwave background temperature anisotropies. This bispectrum-related power spectrum was constructed after weighting the temperature map with the appropriate window functions to form an estimator that probes the multipolar dependence of the underlying bispectrum associated with the primordial non-Gaussianity. We also estimate a separate skewness power spectrum sensitive more strongly to unresolved point sources. When compared to previous attempts at measuring the primordial non-Gaussianity with WMAP data, our estimators have the main advantage that we do not collapse information to a single number. When model fitting the two-to-one skewness power spectrum, we make use of bispectra generated by the primordial non-Gaussianity, radio point sources, and lensing-secondary correlation. We analyze Q, V, and W-band WMAP 5-year data using the KQ75 mask out to l{sub max}=600. Using V and W-band data and marginalizing over model parameters related to point sources and lensing-secondary bispectrum, our overall and preferred constraint on f{sub NL} is 11.0{+-}23.7 at the 68% confidence level (-36.4

  8. Joint Skewness and Its Application in Unsupervised Band Selection for Small Target Detection

    PubMed Central

    Geng, Xiurui; Sun, Kang; Ji, Luyan; Tang, Hairong; Zhao, Yongchao

    2015-01-01

    Few band selection methods are specially designed for small target detection. It is well known that the information of small targets is most likely contained in non-Gaussian bands, where small targets are more easily separated from the background. On the other hand, correlation of band set also plays an important role in the small target detection. When the selected bands are highly correlated, it will be unbeneficial for the subsequent detection. However, the existing non-Gaussianity-based band selection methods have not taken the correlation of bands into account, which generally result in high correlation of obtained bands. In this paper, combining the third-order (third-order tensor) and second-order (correlation) statistics of bands, we define a new concept, named joint skewness, for multivariate data. Moreover, we also propose an easy-to-implement approach to estimate this index based on high-order singular value decomposition (HOSVD). Based on the definition of joint skewness, we present an unsupervised band selection for small target detection for hyperspectral data, named joint skewness band selection (JSBS). The evaluation results demonstrate that the bands selected by JSBS are very effective in terms of small target detection. PMID:25873018

  9. Squaring the Circle: Geometric Skewness and Symmetry Breaking for Passive Scalar Transport in Ducts and Pipes.

    PubMed

    Aminian, Manuchehr; Bernardi, Francesca; Camassa, Roberto; McLaughlin, Richard M

    2015-10-01

    We study the role geometry plays in the emergence of asymmetries in diffusing passive scalars advected by pressure-driven flows in ducts and pipes of different aspect ratios. We uncover nonintuitive, multi-time-scale behavior gauged by a new statistic, which we term "geometric skewness" S^{G}, which measures instantaneously forming asymmetries at short times due to flow geometry. This signature distinguishes elliptical pipes of any aspect ratio, for which S^{G}=0, from rectangular ducts whose S^{G} is generically nonzero, and, interestingly, shows that a special duct of aspect ratio ≈0.53335 behaves like a circular pipe as its geometric skewness vanishes. Using a combination of exact solutions, novel short-time asymptotics, and Monte Carlo simulations, we establish the relevant time scales for plateaus and extrema in the evolution of the skewness and kurtosis for our class of geometries. For ducts limiting to channel geometries, we present new exact, single-series formulas for the first four moments on slices used to benchmark Monte Carlo simulations. PMID:26550727

  10. Stress Analysis of a New Disk-Type Variable Torque Slipping Clutch with Skewed Rollers

    NASA Astrophysics Data System (ADS)

    Feng, Ming; Ono, Kyosuke; Mimura, Kenji

    In this paper a new disk type of the variable torque slipping clutch with skewed rollers (VTSCSR) is presented and investigated both theoretically and experimentally. It is comprised of two flat disks, a number of skewed cylindrical rollers, and a cage. The slipping torque is produced by the skewed rollers rolling and slipping between the two disks. Based on the integral equation of the Boussinesq solution, the contact pressures are numerically calculated under the condition that the nonlinear equilibrium equations of the clutch elements are satisfied. By considering both pressure and friction, the components of subsurface stress are calculated from the integration of the Mindlin's subsurface stress equations of concentrated force. A numerical solver is then successfully developed by which the characteristics of the disk-type VTSCSR, including the torque capacity, angular velocities of the roller and cage, contact pressure and von Mises stress, etc, are calculated and illustrated for the typical designs. The influences on the distribution of the von Mises stress by applying various types of profiled rollers to the disk-type VTSCSR are also discussed. It has been found that the full crown with two arcs profiled roller can approximately give rise to the axially uniform distribution of the von Mises stress and therefore satisfies the design principle of the average damage of materials. In addition, the preliminary experiment was done in order to show the feasibility of this design idea and to verify the theoretical torque capacity.

  11. Reproductive partitioning and the assumptions of reproductive skew models in the cooperatively breeding American crow

    PubMed Central

    Townsend, Andrea K.; Clark, Anne B.; McGowan, Kevin J.; Lovette, Irby J.

    2009-01-01

    Understanding the benefits of cooperative breeding for group members of different social and demographic classes requires knowledge of their reproductive partitioning and genetic relatedness. From 2004-2007, we examined parentage as a function of relatedness and social interactions among members of 21 American crow (Corvus brachyrhynchos) family groups. Paired female breeders monopolized maternity of all offspring in their broods, whereas paired male breeders sired 82.7% of offspring, within-group auxiliary males sired 6.9% of offspring, and extragroup males sired 10.4% of offspring. Although adult females had fewer opportunities for direct reproduction as auxiliaries than males, they appeared to have earlier opportunities for independent breeding. These different opportunities for direct reproduction probably contributed to the male biased adult auxiliary sex ratio. Patterns of reproductive partitioning and conflict among males were most consistent with a synthetic reproductive skew model, in which auxiliaries struggled with breeders for a limited reproductive share, beyond which breeders could evict them. Counter to a frequent assumption of reproductive skew models, female breeders appeared to influence paternity, although their interests might have agreed with the interests of their paired males. Unusual among cooperative breeders, close inbreeding and incest occurred in this population. Incest avoidance between potential breeders did not significantly affect reproductive skew. PMID:20126287

  12. Squaring the Circle: Geometric Skewness and Symmetry Breaking for Passive Scalar Transport in Ducts and Pipes

    NASA Astrophysics Data System (ADS)

    Aminian, Manuchehr; Bernardi, Francesca; Camassa, Roberto; McLaughlin, Richard M.

    2015-10-01

    We study the role geometry plays in the emergence of asymmetries in diffusing passive scalars advected by pressure-driven flows in ducts and pipes of different aspect ratios. We uncover nonintuitive, multi-time-scale behavior gauged by a new statistic, which we term "geometric skewness" SG, which measures instantaneously forming asymmetries at short times due to flow geometry. This signature distinguishes elliptical pipes of any aspect ratio, for which SG=0 , from rectangular ducts whose SG is generically nonzero, and, interestingly, shows that a special duct of aspect ratio ≈0.533 35 behaves like a circular pipe as its geometric skewness vanishes. Using a combination of exact solutions, novel short-time asymptotics, and Monte Carlo simulations, we establish the relevant time scales for plateaus and extrema in the evolution of the skewness and kurtosis for our class of geometries. For ducts limiting to channel geometries, we present new exact, single-series formulas for the first four moments on slices used to benchmark Monte Carlo simulations.

  13. The Equilibrium Allele Frequency Distribution for a Population with Reproductive Skew

    PubMed Central

    Der, Ricky; Plotkin, Joshua B.

    2014-01-01

    We study the population genetics of two neutral alleles under reversible mutation in a model that features a skewed offspring distribution, called the Λ-Fleming–Viot process. We describe the shape of the equilibrium allele frequency distribution as a function of the model parameters. We show that the mutation rates can be uniquely identified from this equilibrium distribution, but the form of the offspring distribution cannot itself always be so identified. We introduce an estimator for the mutation rate that is consistent, independent of the form of reproductive skew. We also introduce a two-allele infinite-sites version of the Λ-Fleming–Viot process, and we use it to study how reproductive skew influences standing genetic diversity in a population. We derive asymptotic formulas for the expected number of segregating sites as a function of sample size and offspring distribution. We find that the Wright–Fisher model minimizes the equilibrium genetic diversity, for a given mutation rate and variance effective population size, compared to all other Λ-processes. PMID:24473932

  14. Deterioration of the skew quadrupole moment in Tevatron dipoles over time

    SciTech Connect

    Syphers, M.J.; Harding, D.J.; /Fermilab

    2005-05-01

    During the 20 years since it was first commissioned, the Fermilab Tevatron has developed strong coupling between the two transverse degrees of freedom. A circuit of skew quadrupole magnets is used to correct for coupling and, though capable, its required strength has increased since 1983 by more than an order of magnitude. In more recent years changes to the Tevatron for colliding beams operation have altered the skew quadrupole corrector distribution and strong local coupling become evident, often encumbering routine operation during the present physics run. Detailed magnet measurements were performed on each individual magnet during construction, and in early 2003 it was realized that measurements could be performed on the magnets in situ which could determine coil movements within the iron yoke since the early 1980's. It was discovered that the superconducting coils had become vertically displaced relative to their yokes since their construction. The ensuing systematic skew quadrupole field introduced by this displacement accounts for the required corrector settings and observed beam behavior. An historical account of the events leading to this discovery and progress toward its remedy are presented.

  15. Beam Stabilization in the SLAC A-line Using a Skew Quadrupole

    SciTech Connect

    Woodley, Mark D

    2002-09-27

    The E158 experiment at SLAC is a precision measurement of the left-right asymmetry in Moeller scattering at low Q{sup 2} utilizing a high-current long-pulse polarized electron beam scattering off unpolarized electrons in a liquid hydrogen target [1]. Tolerances on beam size and position/angle stability for E158 are extremely tight, but the electron beam is subject to intensity jitter, dispersion, and wakefield effects in the linac which tend to make it unstable. Horizontal emittance growth due to synchrotron radiation in the transport line from the linac to the target (''A-line'') reduces the sensitivity of the horizontal beam parameters at the target to incoming changes, but instability in the vertical plane was observed during the E158 pilot run. A skew quadrupole recently installed in the A-line 90 m upstream of the target has been used to couple the projected transverse emittances, increasing the vertical emittance of the beam and thereby reducing its sensitivity to incoming changes. Simulations of the performance of this skew quadrupole, along with measured beam data with and without the skew quadrupole, will be presented.

  16. Reproductive skew drives patterns of sexual dimorphism in sponge-dwelling snapping shrimps

    PubMed Central

    Chak, Solomon Tin Chi; Duffy, J. Emmett; Rubenstein, Dustin R.

    2015-01-01

    Sexual dimorphism is typically a result of strong sexual selection on male traits used in male–male competition and subsequent female choice. However, in social species where reproduction is monopolized by one or a few individuals in a group, selection on secondary sexual characteristics may be strong in both sexes. Indeed, sexual dimorphism is reduced in many cooperatively breeding vertebrates and eusocial insects with totipotent workers, presumably because of increased selection on female traits. Here, we examined the relationship between sexual dimorphism and sociality in eight species of Synalpheus snapping shrimps that vary in social structure and degree of reproductive skew. In species where reproduction was shared more equitably, most members of both sexes were physiologically capable of breeding. However, in species where reproduction was monopolized by a single individual, a large proportion of females—but not males—were reproductively inactive, suggesting stronger reproductive suppression and conflict among females. Moreover, as skew increased across species, proportional size of the major chela—the primary antagonistic weapon in snapping shrimps—increased among females and sexual dimorphism in major chela size declined. Thus, as reproductive skew increases among Synalpheus, female–female competition over reproduction appears to increase, resulting in decreased sexual dimorphism in weapon size. PMID:26041357

  17. Coil Creep and Skew-Quadrupole Field Components in the Tevatron

    SciTech Connect

    Annala, G.; Harding, D.J.; Syphers, M.J.; /Fermilab

    2011-07-11

    During the start-up of Run II of the Tevatron Collider program, several issues surfaced which were not present, or not seen as detrimental, during Run I. These included the repeated deterioration of the closed orbit requiring orbit smoothing every two weeks or so, the inability to correct the closed orbit to desired positions due to various correctors running at maximum limits, regions of systematically strong vertical dipole corrections, and the identification of very strong coupling between the two transverse degrees-of-freedom. It became apparent that many of the problems being experienced operationally were connected to a deterioration of the main dipole magnet alignment, and remedial actions were undertaken. However, the alignment alone was not enough to explain the corrector strengths required to handle transverse coupling. With one exception, strong coupling had generally not been an issue in the Tevatron during Run I. Based on experience with the Main Ring, the Tevatron was designed with a very strong skew quadrupole circuit to compensate any quadrupole alignment and skew quadrupole field errors that might present themselves. The circuit was composed of 48 correctors placed evenly throughout the arcs, 8 per sector, evenly placed in every other cell. Other smaller circuits were installed but not initially needed or commissioned. These smaller circuits were composed of individual skew quadrupole correctors on either side of the long straight sections. These circuits were tuned by first bringing the horizontal and vertical tunes near each other. The skew quadrupoles were then adjusted to minimize tune split, usually to less than 0.003. Initially, the main skew quad circuit (designated T:SQ) could accomplish this global decoupling with only 4% of its possible current, and the smaller circuits were not required at all. The start-up of Run Ib was complicated by what was later discovered to be a rolled triplet quadrupole magnet in one of the Interaction Regions

  18. Wind-tunnel research comparing lateral control devices, particularly at high angles of attack VI : skewed ailerons on rectangular wings

    NASA Technical Reports Server (NTRS)

    Weick, Fred E; Harris, Thomas A

    1934-01-01

    This report covers the sixth of a series of investigations in which various lateral control devices are compared with particular reference to their effectiveness at high angles of attack. The present report deals with flap-type ailerons hinged about axes having an angle with respect to the leading and trailing edges of the wing. Tests were made on four different skewed ailerons, including two different angles of skew and two sizes of ailerons. At the high angles of attack, all the skewed ailerons tested were slightly inferior with respect to rolling and yawing moments to straight ailerons having the same span and average chord. Computations indicate that the skewed ailerons are also inferior with respect to hinge moments.

  19. Inheritance of skewed X chromosome inactivation in a large family with an X-linked recessive deafness syndrome

    SciTech Connect

    Orstavik, K.H.; Orstavik, R.E.; Eiklid, K.; Tranebjaerg, L.

    1996-07-12

    A new X-linked recessive deafness syndrome was recently reported and mapped to Xq22 (Mohr-Tranebjaeerg syndrome). In addition to deafness, the patients had visual impairment, dystonia, fractures, and mental deterioration. The female carriers did not have any significant manifestations of the syndrome. We examined X chromosome inactivation in 8 obligate and 12 possible carriers by using a polymerase chain reaction analysis of the methylation-dependent amplification of the polymorphic triplet repeat at the androgen receptor locus. Seven of 8 obligate carriers and 1 of 5 carriers by linkage analysis had an extremely skewed pattern in blood DNA not found in 30 normal females. The X inactivation pattern in fibroblast DNA from 2 of the carriers with the extremely skewed pattern was also skewed but to a lesser degree than in blood DNA. One obligate carrier had a random X inactivation pattern in both blood and fibroblast DNA. A selection mechanism for the skewed pattern is therefore not likely. The extremely skewed X inactivation in 8 females of 3 generations in this family may be caused by a single gene that influences skewing of X chromosome inactivation. 22 refs., 2 figs., 1 tab.

  20. Heat transfer in rotating serpentine passages with trips skewed to the flow

    NASA Technical Reports Server (NTRS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    1992-01-01

    Experiments were conducted to determine the effects of buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. The experiments were conducted with a large scale, multi-pass, heat transfer model with both radially inward and outward flow. Trip strips, skewed at 45 deg to the flow direction, were machined on the leading and trailing surfaces of the radial coolant passages. An analysis of the governing flow equations showed that four parameters influence the heat transfer in rotating passages: coolant-to-wall temperature, rotation number, Reynolds number, and radius-to-passage hydraulic diameter ratio. The first three of these four parameters were varied over ranges which are typical of advanced gas turbine engine operating conditions. Results were correlated and compared to previous results from similar stationary and rotating models with smooth walls and with trip strips normal to the flow direction. The heat transfer coefficients on surfaces, where the heat transfer decreased with rotation and buoyancy, decreased to as low as 40 percent of the value without rotation. However, the maximum values of the heat transfer coefficients with high rotation were only slightly above the highest levels previously obtained with the smooth wall models. It was concluded that (1) both Coriolis and buoyancy effects must be considered in turbine blade cooling designs with trip strips, (2) the effects of rotation are markedly different depending upon the flow direction, and (3) the heat transfer with skewed trip strips is less sensitive to buoyancy than the heat transfer in models with either smooth or normal trips. Therefore, skewed trip strips rather than normal trip strips are recommended and geometry-specific tests are required for accurate design information.

  1. Heat transfer in rotating serpentine passages with trips skewed to the flow

    NASA Astrophysics Data System (ADS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    Experiments were conducted to determine the effects of buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. The experiments were conducted with a large scale, multi-pass, heat transfer model with both radially inward and outward flow. Trip strips, skewed at 45 deg to the flow direction, were machined on the leading and trailing surfaces of the radial coolant passages. An analysis of the governing flow equations showed that four parameters influence the heat transfer in rotating passages: coolant-to-wall temperature, rotation number, Reynolds number, and radius-to-passage hydraulic diameter ratio. The first three of these four parameters were varied over ranges which are typical of advanced gas turbine engine operating conditions. Results were correlated and compared to previous results from similar stationary and rotating models with smooth walls and with trip strips normal to the flow direction. The heat transfer coefficients on surfaces, where the heat transfer decreased with rotation and buoyancy, decreased to as low as 40 percent of the value without rotation. However, the maximum values of the heat transfer coefficients with high rotation were only slightly above the highest levels previously obtained with the smooth wall models. It was concluded that (1) both Coriolis and buoyancy effects must be considered in turbine blade cooling designs with trip strips, (2) the effects of rotation are markedly different depending upon the flow direction, and (3) the heat transfer with skewed trip strips is less sensitive to buoyancy than the heat transfer in models with either smooth or normal trips. Therefore, skewed trip strips rather than normal trip strips are recommended and geometry-specific tests are required for accurate design information.

  2. Eigenvalue analysis of an irreversible random walk with skew detailed balance conditions.

    PubMed

    Sakai, Yuji; Hukushima, Koji

    2016-04-01

    An irreversible Markov-chain Monte Carlo (MCMC) algorithm with skew detailed balance conditions originally proposed by Turitsyn et al. is extended to general discrete systems on the basis of the Metropolis-Hastings scheme. To evaluate the efficiency of our proposed method, the relaxation dynamics of the slowest mode and the asymptotic variance are studied analytically in a random walk on one dimension. It is found that the performance in irreversible MCMC methods violating the detailed balance condition is improved by appropriately choosing parameters in the algorithm. PMID:27176439

  3. Uniform persistence and upper Lyapunov exponents for monotone skew-product semiflows

    NASA Astrophysics Data System (ADS)

    Novo, Sylvia; Obaya, Rafael; Sanz, Ana M.

    2013-09-01

    Several results of uniform persistence above and below a minimal set of an abstract monotone skew-product semiflow are obtained. When the minimal set has a continuous separation the results are given in terms of the principal spectrum. In the case that the semiflow is generated by the solutions of a family of non-autonomous differential equations of ordinary, delay or parabolic type, the former results are strongly improved. A method of calculus of the upper Lyapunov exponent of the minimal set is also determined.

  4. Skewed X-chromosome inactivation in female carriers of dyskeratosis congenita

    SciTech Connect

    Devriendt, K.; Matthijs, G.; Legius, E.

    1997-03-01

    In this study, we report on a family with X-linked dyskeratosis congenita (DC). Linkage analysis with markers in the factor VIII gene at Xq28 yielded a LOD score of 2 at a recombination of 0. Clinical manifestations of DC, such as skin lesions following the Blaschko lines, were present in two obligate carrier females. Highly skewed X inactivation was observed in white blood cells, cultured skin fibroblasts, and buccal mucosa from female carriers of DC in this family. This suggests a critical role for the DC gene in bone marrow-cell and fibroblast-cell proliferation. 23 refs., 4 figs., 1 tab.

  5. Measuring Skew in Average Surface Roughness as a Function of Surface Preparation

    NASA Technical Reports Server (NTRS)

    Stahl, Mark

    2015-01-01

    Characterizing surface roughness is important for predicting optical performance. Better measurement of surface roughness reduces polishing time, saves money and allows the science requirements to be better defined. This study characterized statistics of average surface roughness as a function of polishing time. Average surface roughness was measured at 81 locations using a Zygo white light interferometer at regular intervals during the polishing process. Each data set was fit to a normal and Largest Extreme Value (LEV) distribution; then tested for goodness of fit. We show that the skew in the average data changes as a function of polishing time.

  6. Autonomous fault-tolerant attitude reference system using DTGs in symmetrically skewed configuration

    NASA Technical Reports Server (NTRS)

    Murugesan, S.; Goel, P. S.

    1989-01-01

    A novel symmetrically skewed configuration for an attitude reference system (ARS) using three dynamically tuned gyros (DTGs) is developed. Simple schemes for autonomous detection and identification of a faulty DTG in real time and subsequent reconfiguration of the attitude estimation algorithm are proposed. The performance of the present configuration is shown to be better than that of configurations proposed earlier, and it is shown to have better features. It tolerates all types of failures of DTG failures, requires very simple computations, and gives less error in attitude estimate than the other configurations.

  7. Measuring Skew in Average Surface Roughness as a Function of Surface Preparation

    NASA Technical Reports Server (NTRS)

    Stahl, Mark T.

    2015-01-01

    Characterizing surface roughness is important for predicting optical performance. Better measurement of surface roughness reduces grinding saving both time and money and allows the science requirements to be better defined. In this study various materials are polished from a fine grind to a fine polish. Each sample's RMS surface roughness is measured at 81 locations in a 9x9 square grid using a Zygo white light interferometer at regular intervals during the polishing process. Each data set is fit with various standard distributions and tested for goodness of fit. We show that the skew in the RMS data changes as a function of polishing time.

  8. Measuring skew in average surface roughness as a function of surface preparation

    NASA Astrophysics Data System (ADS)

    Stahl, Mark T.

    2015-08-01

    Characterizing surface roughness is important for predicting optical performance. Better measurement of surface roughness reduces polishing time, saves money and allows the science requirements to be better defined. This study characterized statistics of average surface roughness as a function of polishing time. Average surface roughness was measured at 81 locations using a Zygo® white light interferometer at regular intervals during the polishing process. Each data set was fit to a normal and Largest Extreme Value (LEV) distribution; then tested for goodness of fit. We show that the skew in the average data changes as a function of polishing time.

  9. Analytical shape sensitivities and approximations of modal response of generally laminated tapered skew plates

    NASA Technical Reports Server (NTRS)

    Singhvi, Sarvesh; Kapania, Rakesh K.

    1992-01-01

    In the present determination of the derivatives of natural frequencies and mode shapes of a generally laminated tapered skew plate, with respect to various shape parameters, springs are used to simulate the essential boundary conditions. The independent shape parameters are plate surface area, aspect ratio, taper ratio, and sweep angle. Eigenvalues and eigenvectors are approximated over the range of the variable using linear, exponential, and pseudoexponential approximation schemes, and are compared with reanalysis-obtained values. Numerical results are presented for symmetrically and unsymmetrically laminated plates.

  10. Eigenvalue analysis of an irreversible random walk with skew detailed balance conditions

    NASA Astrophysics Data System (ADS)

    Sakai, Yuji; Hukushima, Koji

    2016-04-01

    An irreversible Markov-chain Monte Carlo (MCMC) algorithm with skew detailed balance conditions originally proposed by Turitsyn et al. is extended to general discrete systems on the basis of the Metropolis-Hastings scheme. To evaluate the efficiency of our proposed method, the relaxation dynamics of the slowest mode and the asymptotic variance are studied analytically in a random walk on one dimension. It is found that the performance in irreversible MCMC methods violating the detailed balance condition is improved by appropriately choosing parameters in the algorithm.

  11. A q-Analogue of the Centralizer Construction and Skew Representations of the Quantum Affine Algebra

    NASA Astrophysics Data System (ADS)

    Hopkins, Mark J.; Molev, Alexander I.

    2006-12-01

    We prove an analogue of the Sylvester theorem for the generator matrices of the quantum affine algebra Uq(gln). We then use it to give an explicit realization of the skew representations of the quantum affine algebra. This allows one to identify them in a simple way by calculating their highest weight, Drinfeld polynomials and the Gelfand-Tsetlin character (or q-character). We also apply the quantum Sylvester theorem to construct a q-analogue of the Olshanski algebra as a projective limit of certain centralizers in Uq(gln) and show that this limit algebra contains the q-Yangian as a subalgebra.

  12. Using Skewness and the First-Digit Phenomenon to Identify Dynamical Transitions in Cardiac Models

    PubMed Central

    Seenivasan, Pavithraa; Easwaran, Soumya; Sridhar, Seshan; Sinha, Sitabhra

    2016-01-01

    Disruptions in the normal rhythmic functioning of the heart, termed as arrhythmia, often result from qualitative changes in the excitation dynamics of the organ. The transitions between different types of arrhythmia are accompanied by alterations in the spatiotemporal pattern of electrical activity that can be measured by observing the time-intervals between successive excitations of different regions of the cardiac tissue. Using biophysically detailed models of cardiac activity we show that the distribution of these time-intervals exhibit a systematic change in their skewness during such dynamical transitions. Further, the leading digits of the normalized intervals appear to fit Benford's law better at these transition points. This raises the possibility of using these observations to design a clinical indicator for identifying changes in the nature of arrhythmia. More importantly, our results reveal an intriguing relation between the changing skewness of a distribution and its agreement with Benford's law, both of which have been independently proposed earlier as indicators of regime shift in dynamical systems. PMID:26793114

  13. Deconstructing risk: Separable encoding of variance and skewness in the brain

    PubMed Central

    Symmonds, Mkael; Wright, Nicholas D.; Bach, Dominik R.; Dolan, Raymond J.

    2011-01-01

    Risky choice entails a need to appraise all possible outcomes and integrate this information with individual risk preference. Risk is frequently quantified solely by statistical variance of outcomes, but here we provide evidence that individuals’ choice behaviour is sensitive to both dispersion (variance) and asymmetry (skewness) of outcomes. Using a novel behavioural paradigm in humans, we independently manipulated these ‘summary statistics’ while scanning subjects with fMRI. We show that a behavioural sensitivity to variance and skewness is mirrored in neuroanatomically dissociable representations of these quantities, with parietal cortex showing sensitivity to the former and prefrontal cortex and ventral striatum to the latter. Furthermore, integration of these objective risk metrics with subjective risk preference is expressed in a subject-specific coupling between neural activity and choice behaviour in anterior insula. Our findings show that risk is neither monolithic from a behavioural nor neural perspective and its decomposition is evident both in distinct behavioural preferences and in segregated underlying brain representations. PMID:21763444

  14. Homoclinic snaking in plane Couette flow: bending, skewing and finite-size effects

    NASA Astrophysics Data System (ADS)

    Gibson, J. F.; Schneider, T. M.

    2016-05-01

    Invariant solutions of shear flows have recently been extended from spatially periodic solutions in minimal flow units to spatially localized solutions on extended domains. One set of spanwise-localized solutions of plane Couette flow exhibits homoclinic snaking, a process by which steady-state solutions grow additional structure smoothly at their fronts when continued parametrically. Homoclinic snaking is well understood mathematically in the context of the one-dimensional Swift-Hohenberg equation. Consequently, the snaking solutions of plane Couette flow form a promising connection between the largely phenomenological study of laminar-turbulent patterns in viscous shear flows and the mathematically well-developed field of pattern-formation theory. In this paper we present a numerical study of the snaking solutions, generalizing beyond the fixed streamwise wavelength of previous studies. We find a number of new solution features, including bending, skewing, and finite-size effects. We show that the finite-size effects result from the shift-reflect symmetry of the traveling wave and establish the parameter regions over which snaking occurs. A new winding solution of plane Couette flow is derived from a strongly skewed localized equilibrium.

  15. Heat transfer in rotating serpentine passages with trips skewed to the flow

    NASA Technical Reports Server (NTRS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    1992-01-01

    Experiments were conducted to determine the effects of buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. The experiments were conducted with a large scale, multi-pass heat transfer model with both radially inward and outward flow. An analysis of the governing flow equations showed that four parameters influence the heat transfer in rotating passages: coolant-to-wall temperature, rotation number, Reynolds number, and radius-to-passage hydraulic diameter ratio. Results were correlated and compared to previous results from similar stationary and rotating models with smooth walls and with trip strips normal to the flow direction. It was concluded that (1) both Coriolis and buoyancy must be considered in turbine blade cooling designs with trip strips, (2) the effects of rotation are markedly different depending upon the flow direction, and (3) the heat transfer with skewed trip strips is less sensitive to buoyancy than the heat transfer models with either smooth or normal trips. Therefore, skewed trip strips rather than normal trip strips are recommended and geometry-specific tests are required for accurate design.

  16. Skewness and kurtosis as indicators of non-Gaussianity in galactic foreground maps

    NASA Astrophysics Data System (ADS)

    Ben-David, Assaf; von Hausegger, Sebastian; Jackson, Andrew D.

    2015-11-01

    Observational cosmology is entering an era in which high precision will be required in both measurement and data analysis. Accuracy, however, can only be achieved with a thorough understanding of potential sources of contamination from foreground effects. Our primary focus will be on non-Gaussian effects in foregrounds. This issue will be crucial for coming experiments to determine B-mode polarization. We propose a novel method for investigating a data set in terms of skewness and kurtosis in locally defined regions that collectively cover the entire sky. The method is demonstrated on two sky maps: (i) the SMICA map of Cosmic Microwave Background fluctuations provided by the Planck Collaboration and (ii) a version of the Haslam map at 408 MHz that describes synchrotron radiation. We find that skewness and kurtosis can be evaluated in combination to reveal local physical information. In the present case, we demonstrate that the statistical properties of both maps in small local regions are predominantly Gaussian. This result was expected for the SMICA map. It is surprising that it also applies for the Haslam map given its evident large scale non-Gaussianity. The approach described here has a generality and flexibility that should make it useful in a variety of astrophysical and cosmological contexts.

  17. Using Skewness and the First-Digit Phenomenon to Identify Dynamical Transitions in Cardiac Models.

    PubMed

    Seenivasan, Pavithraa; Easwaran, Soumya; Sridhar, Seshan; Sinha, Sitabhra

    2015-01-01

    Disruptions in the normal rhythmic functioning of the heart, termed as arrhythmia, often result from qualitative changes in the excitation dynamics of the organ. The transitions between different types of arrhythmia are accompanied by alterations in the spatiotemporal pattern of electrical activity that can be measured by observing the time-intervals between successive excitations of different regions of the cardiac tissue. Using biophysically detailed models of cardiac activity we show that the distribution of these time-intervals exhibit a systematic change in their skewness during such dynamical transitions. Further, the leading digits of the normalized intervals appear to fit Benford's law better at these transition points. This raises the possibility of using these observations to design a clinical indicator for identifying changes in the nature of arrhythmia. More importantly, our results reveal an intriguing relation between the changing skewness of a distribution and its agreement with Benford's law, both of which have been independently proposed earlier as indicators of regime shift in dynamical systems. PMID:26793114

  18. Optimal reproductive-skew models fail to predict aggression in wasps.

    PubMed

    Nonacs, Peter; Reeve, H Kern; Starks, Philip T

    2004-04-22

    Optimal-skew models (OSMs) predict that cooperative breeding occurs as a result of dominants conceding reproductive benefits to subordinates, and that division of reproduction within groups reflects each cooperator's willingness and ability to contest aggressively for dominance. Polistine paper wasps are a leading model system for testing OSMs, and data on reproduction and aggression appear to support OSMs. These studies, however, measure aggression as a single rate rather than by the activity patterns of individuals. This leads to a potential error: if individuals are more likely to receive aggression when active than when inactive, differences in aggression across samples can reflect changes in activity rather than hostility. This study replicates a field manipulation cited as strongly supporting OSMs. We show that fundamentally different conclusions arise when controlling for individual activity states. Our analyses strongly suggest that behaviours classified as 'aggression' in paper wasps are unlikely to function in establishing, maintaining or responding to changes in reproductive skew. This illustrates that OSM tests using aggression or other non-reproductive behaviour as a metric for reproductive partitioning must demonstrate those links rather than assume them. PMID:15255099

  19. Optimal reproductive-skew models fail to predict aggression in wasps.

    PubMed Central

    Nonacs, Peter; Reeve, H. Kern; Starks, Philip T.

    2004-01-01

    Optimal-skew models (OSMs) predict that cooperative breeding occurs as a result of dominants conceding reproductive benefits to subordinates, and that division of reproduction within groups reflects each cooperator's willingness and ability to contest aggressively for dominance. Polistine paper wasps are a leading model system for testing OSMs, and data on reproduction and aggression appear to support OSMs. These studies, however, measure aggression as a single rate rather than by the activity patterns of individuals. This leads to a potential error: if individuals are more likely to receive aggression when active than when inactive, differences in aggression across samples can reflect changes in activity rather than hostility. This study replicates a field manipulation cited as strongly supporting OSMs. We show that fundamentally different conclusions arise when controlling for individual activity states. Our analyses strongly suggest that behaviours classified as 'aggression' in paper wasps are unlikely to function in establishing, maintaining or responding to changes in reproductive skew. This illustrates that OSM tests using aggression or other non-reproductive behaviour as a metric for reproductive partitioning must demonstrate those links rather than assume them. PMID:15255099

  20. Hematopoietic lineage skewing and intestinal epithelia degeneration in aged mice with telomerase RNA component deletion.

    PubMed

    Chen, Jichun; Bryant, Mark A; Dent, James J; Sun, Yu; Desierto, Marie J; Young, Neal S

    2015-12-01

    A deletion of a telomerase RNA component (Terc(-/-)) in C57BL/6 (B6) mice resulted in hematopoietic lineage skewing with increased neutrophils and CD11b(+) myeloid cells and decreased red blood cells and CD45R(+) B lymphocytes when animals reach ages older than 12 months. There was no decline in bone marrow (BM) c-Kit(+)Sca-1(+)Lin(-) (KSL) cells in old Terc(-/-) mice, and the lineage skewing phenomenon was not transferred when BM cells from old Terc(-/-) donors were transplanted into young B6 recipients. Necropsy and histological examinations found minimal to no change in the lung, spleen and liver but detected severe epithelia degeneration, ulceration and infection in small and large intestines, leading to enteritis, typhlitis and colitis in old Terc(-/-) mice. In a mouse model of dextran-sulfate-sodium-induced typhlitis and colitis, development of intestinal pathology was associated with increases in neutrophils and CD11b(+) myeloid cells and a decrease in CD45R(+) B cells, similar to those observed in old Terc(-/-) mice. Treatment of 11-13 month old Terc(-/-) mice with antibiotic trimethoprim-sulfa water reduced neutrophils and myeloid cells and increased B lymphocytes in the blood, indicating that mitigation of intestinal infection and inflammation could alleviate hematological abnormalities in old Terc(-/-) animals. PMID:26523501

  1. Understanding the distinctively skewed and heavy tailed character of atmospheric and oceanic probability distributions

    SciTech Connect

    Sardeshmukh, Prashant D.

    2015-03-15

    The probability distributions of large-scale atmospheric and oceanic variables are generally skewed and heavy-tailed. We argue that their distinctive departures from Gaussianity arise fundamentally from the fact that in a quadratically nonlinear system with a quadratic invariant, the coupling coefficients between system components are not constant but depend linearly on the system state in a distinctive way. In particular, the skewness arises from a tendency of the system trajectory to linger near states of weak coupling. We show that the salient features of the observed non-Gaussianity can be captured in the simplest such nonlinear 2-component system. If the system is stochastically forced and linearly damped, with one component damped much more strongly than the other, then the strongly damped fast component becomes effectively decoupled from the weakly damped slow component, and its impact on the slow component can be approximated as a stochastic noise forcing plus an augmented nonlinear damping. In the limit of large time-scale separation, the nonlinear augmentation of the damping becomes small, and the noise forcing can be approximated as an additive noise plus a correlated additive and multiplicative noise (CAM noise) forcing. Much of the diversity of observed large-scale atmospheric and oceanic probability distributions can be interpreted in this minimal framework.

  2. Maximum Parsimony and the Skewness Test: A Simulation Study of the Limits of Applicability

    PubMed Central

    Määttä, Jussi; Roos, Teemu

    2016-01-01

    The maximum parsimony (MP) method for inferring phylogenies is widely used, but little is known about its limitations in non-asymptotic situations. This study employs large-scale computations with simulated phylogenetic data to estimate the probability that MP succeeds in finding the true phylogeny for up to twelve taxa and 256 characters. The set of candidate phylogenies are taken to be unrooted binary trees; for each simulated data set, the tree lengths of all (2n − 5)!! candidates are computed to evaluate quantities related to the performance of MP, such as the probability of finding the true phylogeny, the probability that the tree with the shortest length is unique, the probability that the true phylogeny has the shortest tree length, and the expected inverse of the number of trees sharing the shortest length. The tree length distributions are also used to evaluate and extend the skewness test of Hillis for distinguishing between random and phylogenetic data. The results indicate, for example, that the critical point after which MP achieves a success probability of at least 0.9 is roughly around 128 characters. The skewness test is found to perform well on simulated data and the study extends its scope to up to twelve taxa. PMID:27035667

  3. Heat transfer in rotating serpentine passages with trips skewed to the flow

    NASA Astrophysics Data System (ADS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    1992-06-01

    Experiments were conducted to determine the effects of buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. The experiments were conducted with a large scale, multi-pass heat transfer model with both radially inward and outward flow. An analysis of the governing flow equations showed that four parameters influence the heat transfer in rotating passages: coolant-to-wall temperature, rotation number, Reynolds number, and radius-to-passage hydraulic diameter ratio. Results were correlated and compared to previous results from similar stationary and rotating models with smooth walls and with trip strips normal to the flow direction. It was concluded that (1) both Coriolis and buoyancy must be considered in turbine blade cooling designs with trip strips, (2) the effects of rotation are markedly different depending upon the flow direction, and (3) the heat transfer with skewed trip strips is less sensitive to buoyancy than the heat transfer models with either smooth or normal trips. Therefore, skewed trip strips rather than normal trip strips are recommended and geometry-specific tests are required for accurate design.

  4. Near and Far Field Acoustic Pressure Skewness in a Heated Supersonic Jet

    NASA Astrophysics Data System (ADS)

    Gutmark, Ephraim; Mora, Pablo; Kastner, Jeff; Heeb, Nick; Kailasanath, Kailas; Liu, Junhui; University of Cincinnati Collaboration; Naval Research Laboratory Collaboration

    2012-11-01

    The dominant component of turbulent mixing noise in high speed jets is the Mach wave radiation generated by large turbulent structures in the shear layer The Over-All Sound Pressure Level (OASPL) in the far field peaks in a direction near the Mach wave angle. ``Crackle'' is another important component of high speed jet noise. Crackle cannot be recognized in the spectrum of the acoustic pressure signal, but it appears in the temporal waveform of the pressure as sharply rising peaks. Skewness levels of the pressure and dP/dt have been used as a measure of crackle in high specific thrust engines and rockets. In this paper, we focus on recognizing a technique that identifies the impact of different test conditions on the near-field and far-field statistics of the pressure and dP/dt signals of a supersonic jet with a design Mach number of Md=1.5 produced by a C-D conical nozzle. Cold and hot jets, T0=300K and 600K, are tested at over, design, and under-expanded conditions, with NPRs=2.5, 3.671, 4.5, respectively. Second, Third and Forth order statistics are examined in the near and far fields. Rms, skewness and kurtosis intensity levels and propagation are better identified in the dP/dt than in the pressure signal. Statistics of the dP/dt demonstrate to be a better measure for crackle. Project funded by ONR grant.

  5. Comment on "Universal relation between skewness and kurtosis in complex dynamics"

    NASA Astrophysics Data System (ADS)

    Celikoglu, Ahmet; Tirnakli, Ugur

    2015-12-01

    In a recent paper [M. Cristelli, A. Zaccaria, and L. Pietronero, Phys. Rev. E 85, 066108 (2012), 10.1103/PhysRevE.85.066108], the authors analyzed the relation between skewness and kurtosis for complex dynamical systems, and they identified two power-law regimes of non-Gaussianity, one of which scales with an exponent of 2 and the other with 4 /3 . They concluded that the observed relation is a universal fact in complex dynamical systems. In this Comment, we test the proposed universal relation between skewness and kurtosis with a large number of synthetic data, and we show that in fact it is not a universal relation and originates only due to the small number of data points in the datasets considered. The proposed relation is tested using a family of non-Gaussian distribution known as q -Gaussians. We show that this relation disappears for sufficiently large datasets provided that the fourth moment of the distribution is finite. We find that kurtosis saturates to a single value, which is of course different from the Gaussian case (K =3 ), as the number of data is increased, and this indicates that the kurtosis will converge to a finite single value if all moments of the distribution up to fourth are finite. The converged kurtosis value for the finite fourth-moment distributions and the number of data points needed to reach this value depend on the deviation of the original distribution from the Gaussian case.

  6. Weighted skewness and kurtosis unbiased by sample size and Gaussian uncertainties

    NASA Astrophysics Data System (ADS)

    Rimoldini, Lorenzo

    2014-07-01

    Central moments and cumulants are often employed to characterize the distribution of data. The skewness and kurtosis are particularly useful for the detection of outliers, the assessment of departures from normally distributed data, automated classification techniques and other applications. Estimators of higher order moments that are robust against outliers are more stable but might miss characteristic features of the data, as in the case of astronomical time series exhibiting brief events like stellar bursts or eclipses of binary systems, while weighting can help identify reliable measurements from uncertain or spurious outliers. Furthermore, noise is an unavoidable part of most measurements and their uncertainties need to be taken properly into account during the data analysis or biases are likely to emerge in the results, including basic descriptive statistics. This work provides unbiased estimates of the weighted skewness and kurtosis moments and cumulants, corrected for biases due to sample size and Gaussian noise, under the assumption of independent data. A comparison of biased and unbiased weighted estimators is illustrated with simulations as a function of sample size and signal-to-noise ratio, employing different data distributions and weighting schemes related to measurement uncertainties and the sampling of the signal. Detailed derivations and figures of simulation results are presented in the Appendices available online.

  7. Analyzing Fish Condition Factor Index Through Skew-Gaussian Information Theory Quantifiers

    NASA Astrophysics Data System (ADS)

    Contreras-Reyes, Javier E.

    2016-06-01

    Biological-fishery indicators have been widely studied. As such the condition factor (CF) index, which interprets the fatness level of a certain species based on length and weight, has been investigated, too. However, CF has been studied without considering its temporal features and distribution. In this paper, we analyze the CF time series via skew-gaussian distributions that consider the asymmetry produced by extreme events. This index is characterized by a threshold autoregressive model and corresponds to a stationary process depending on the shape parameter of the skew-gaussian distribution. Then we use the Jensen-Shannon (JS) distance to compare CF by length classes. This distance has mathematical advantages over other divergences such as Kullback-Leibler and Jeffrey’s, and the triangular inequality property. Our results are applied to a biological catalogue of anchovy (Engraulis ringens) from the northern coast of Chile, for the period 1990-2010 that consider monthly CF time series by length classes and sex. We find that for high values of shape parameter, JS distance tends to be more sensible to detect discrepancies than Jeffrey’s divergence. In addition, the body condition of male anchovies with higher lengths coincides with the ending of the moderate-strong El Niño event 91-92 and for both males and females, the smaller lengths coincide with the beginning of the strong El Niño event 97-98.

  8. Fuel cell plates with skewed process channels for uniform distribution of stack compression load

    DOEpatents

    Granata, Jr., Samuel J.; Woodle, Boyd M.

    1989-01-01

    An electrochemical fuel cell includes an anode electrode, a cathode electrode, an electrolyte matrix sandwiched between electrodes, and a pair of plates above and below the electrodes. The plate above the electrodes has a lower surface with a first group of process gas flow channels formed thereon and the plate below the electrodes has an upper surface with a second group of process gas flow channels formed thereon. The channels of each group extend generally parallel to one another. The improvement comprises the process gas flow channels on the lower surface of the plate above the anode electrode and the process gas flow channels on the upper surface of the plate below the cathode electrode being skewed in opposite directions such that contact areas of the surfaces of the plates through the electrodes are formed in crisscross arrangements. Also, the plates have at least one groove in areas of the surfaces thereof where the channels are absent for holding process gas and increasing electrochemical activity of the fuel cell. The groove in each plate surface intersects with the process channels therein. Also, the opposite surfaces of a bipolar plate for a fuel cell contain first and second arrangements of process gas flow channels in the respective surfaces which are skewed the same amount in opposite directions relative to the longitudinal centerline of the plate.

  9. Understanding the distinctively skewed and heavy tailed character of atmospheric and oceanic probability distributions

    NASA Astrophysics Data System (ADS)

    Sardeshmukh, Prashant D.; Penland, Cécile

    2015-03-01

    The probability distributions of large-scale atmospheric and oceanic variables are generally skewed and heavy-tailed. We argue that their distinctive departures from Gaussianity arise fundamentally from the fact that in a quadratically nonlinear system with a quadratic invariant, the coupling coefficients between system components are not constant but depend linearly on the system state in a distinctive way. In particular, the skewness arises from a tendency of the system trajectory to linger near states of weak coupling. We show that the salient features of the observed non-Gaussianity can be captured in the simplest such nonlinear 2-component system. If the system is stochastically forced and linearly damped, with one component damped much more strongly than the other, then the strongly damped fast component becomes effectively decoupled from the weakly damped slow component, and its impact on the slow component can be approximated as a stochastic noise forcing plus an augmented nonlinear damping. In the limit of large time-scale separation, the nonlinear augmentation of the damping becomes small, and the noise forcing can be approximated as an additive noise plus a correlated additive and multiplicative noise (CAM noise) forcing. Much of the diversity of observed large-scale atmospheric and oceanic probability distributions can be interpreted in this minimal framework.

  10. Random sampling of skewed distributions implies Taylor's power law of fluctuation scaling.

    PubMed

    Cohen, Joel E; Xu, Meng

    2015-06-23

    Taylor's law (TL), a widely verified quantitative pattern in ecology and other sciences, describes the variance in a species' population density (or other nonnegative quantity) as a power-law function of the mean density (or other nonnegative quantity): Approximately, variance = a(mean)(b), a > 0. Multiple mechanisms have been proposed to explain and interpret TL. Here, we show analytically that observations randomly sampled in blocks from any skewed frequency distribution with four finite moments give rise to TL. We do not claim this is the only way TL arises. We give approximate formulae for the TL parameters and their uncertainty. In computer simulations and an empirical example using basal area densities of red oak trees from Black Rock Forest, our formulae agree with the estimates obtained by least-squares regression. Our results show that the correlated sampling variation of the mean and variance of skewed distributions is statistically sufficient to explain TL under random sampling, without the intervention of any biological or behavioral mechanisms. This finding connects TL with the underlying distribution of population density (or other nonnegative quantity) and provides a baseline against which more complex mechanisms of TL can be compared. PMID:25852144

  11. Skewed B cell differentiation affects lymphoid organogenesis but not T cell-mediated autoimmunity.

    PubMed

    Colombo, E; Tentorio, P; Musio, S; Rajewsky, K; Pedotti, R; Casola, S; Farina, C

    2014-04-01

    B cell receptor (BCR) signalling determines B cell differentiation and may potentially alter T cell-mediated immune responses. In this study we used two transgenic strains of BCR-deficient mice expressing Epstein-Barr virus latent membrane protein (LMP)2A in B cells, where either follicular and marginal zone differentiation (D(H)LMP2A mice) or B-1 cell development (V(H)LMP2A mice) were supported, and evaluated the effects of skewed B lymphocyte differentiation on lymphoid organogenesis and T cell responses in vivo. Compared to wild-type animals, both transgenic strains displayed alterations in the composition of lymphoid organs and in the dynamics of distinct immune cell subsets following immunization with the self-antigen PLP₁₈₅₋₂₀₆. However, ex-vivo T cell proliferation to PLP₁₈₅₋₂₀₆ peptide measured in immunized D(H)LMP2A and V(H)LMP2A mice was similar to that detected in immunized control mice. Further, clinical expression of experimental autoimmune encephalitis in both LMP2A strains was identical to that of wild-type mice. In conclusion, mice with skewed B cell differentiation driven by LMP2A expression in BCR-negative B cells do not show changes in the development of a T cell mediated disease model of autoimmunity, suggesting that compensatory mechanisms support the generation of T cell responses. PMID:24325711

  12. Differential properties and attracting sets of a simplest skew product of interval maps

    SciTech Connect

    Efremova, Lyudmila S

    2010-08-12

    For a skew product of interval maps with a closed set of periodic points, the dependence of the structure of its {omega}-limit sets on its differential properties is investigated. An example of a map in this class is constructed which has the maximal differentiability properties (within a certain subclass) with respect to the variable x, is C{sup 1}-smooth in the y-variable and has one-dimensional {omega}-limit sets. Theorems are proved that give necessary conditions for one-dimensional {omega}-limit sets to exist. One of them is formulated in terms of the divergence of the series consisting of the values of a function of x; this function is the C{sup 0}-norm of the deviation of the restrictions of the fibre maps to some nondegenerate closed interval from the identity on the same interval. Another theorem is formulated in terms of the properties of the partial derivative with respect to x of the fibre maps. A complete description is given of the {omega}-limit sets of certain class of C{sup 1}-smooth skew products satisfying some natural conditions. Bibliography: 33 titles.

  13. Maximum Parsimony and the Skewness Test: A Simulation Study of the Limits of Applicability.

    PubMed

    Määttä, Jussi; Roos, Teemu

    2016-01-01

    The maximum parsimony (MP) method for inferring phylogenies is widely used, but little is known about its limitations in non-asymptotic situations. This study employs large-scale computations with simulated phylogenetic data to estimate the probability that MP succeeds in finding the true phylogeny for up to twelve taxa and 256 characters. The set of candidate phylogenies are taken to be unrooted binary trees; for each simulated data set, the tree lengths of all (2n - 5)!! candidates are computed to evaluate quantities related to the performance of MP, such as the probability of finding the true phylogeny, the probability that the tree with the shortest length is unique, the probability that the true phylogeny has the shortest tree length, and the expected inverse of the number of trees sharing the shortest length. The tree length distributions are also used to evaluate and extend the skewness test of Hillis for distinguishing between random and phylogenetic data. The results indicate, for example, that the critical point after which MP achieves a success probability of at least 0.9 is roughly around 128 characters. The skewness test is found to perform well on simulated data and the study extends its scope to up to twelve taxa. PMID:27035667

  14. Enhancing tumor apparent diffusion coefficient histogram skewness stratifies the postoperative survival in recurrent glioblastoma multiforme patients undergoing salvage surgery.

    PubMed

    Zolal, Amir; Juratli, Tareq A; Linn, Jennifer; Podlesek, Dino; Sitoci Ficici, Kerim Hakan; Kitzler, Hagen H; Schackert, Gabriele; Sobottka, Stephan B; Rieger, Bernhard; Krex, Dietmar

    2016-05-01

    Objective To determine the value of apparent diffusion coefficient (ADC) histogram parameters for the prediction of individual survival in patients undergoing surgery for recurrent glioblastoma (GBM) in a retrospective cohort study. Methods Thirty-one patients who underwent surgery for first recurrence of a known GBM between 2008 and 2012 were included. The following parameters were collected: age, sex, enhancing tumor size, mean ADC, median ADC, ADC skewness, ADC kurtosis and fifth percentile of the ADC histogram, initial progression free survival (PFS), extent of second resection and further adjuvant treatment. The association of these parameters with survival and PFS after second surgery was analyzed using log-rank test and Cox regression. Results Using log-rank test, ADC histogram skewness of the enhancing tumor was significantly associated with both survival (p = 0.001) and PFS after second surgery (p = 0.005). Further parameters associated with prolonged survival after second surgery were: gross total resection at second surgery (p = 0.026), tumor size (0.040) and third surgery (p = 0.003). In the multivariate Cox analysis, ADC histogram skewness was shown to be an independent prognostic factor for survival after second surgery. Conclusion ADC histogram skewness of the enhancing lesion, enhancing lesion size, third surgery, as well as gross total resection have been shown to be associated with survival following the second surgery. ADC histogram skewness was an independent prognostic factor for survival in the multivariate analysis. PMID:26830088

  15. Modeling Landscape-Level Spatial Variation in Sex Ratio Skew in the Mountain Pine Beetle (Coleoptera: Curculionidae).

    PubMed

    James, Patrick M A; Janes, Jasmine K; Roe, Amanda D; Cooke, Barry J

    2016-08-01

    Through their influence on effective population sizes, sex ratio skew affects population dynamics. We examined spatial variation in female-biased sex ratios in the mountain pine beetle (Dendroctonus ponderosae Hopkins) outbreak in western Canada to better understand how environmental context affects sex ratio skew. Our specific objectives were to: 1) characterize spatial variation in mountain pine beetle sex ratio; 2) test previously asserted hypotheses that beetle sex ratio varies with tree diameter and year in outbreak; and 3) develop predictive models of sex ratio skew for larval and adult populations. Using logistic regression, we modeled the probability that an individual beetle (n = 2,369) was female as a function of multiple environmental variables across 34 stands in British Columbia and Alberta, Canada. We identified a consistent female-biased sex ratio with significantly greater skew in adults (2:1, n = 713) than in larvae (1.76:1, n = 1,643). We found that the proportion of larval females increased with decreasing tree size and with outbreak age. However, adults did not respond to tree size and larvae did not respond to outbreak age. Predictive models differed between larvae and adults. All identified models perform well and included predictors related to weather, tree diameter, and year in outbreak. Female-biased sex ratios appear to originate from differential male mortality during development rather than from sex-biased oviposition, suggesting sex ratio skew is not the cause of outbreaks, but rather a consequence. PMID:27209334

  16. Development of a contour map showing generalized skew coefficients of annual peak discharges of rural, unregulated streams in New York, excluding Long Island

    USGS Publications Warehouse

    Lumia, Richard; Baevsky, Yvonne H.

    2000-01-01

    Flood-frequency relations that are developed by fitting the logarithms of annual peak discharges to a Pearson Type-III distribution are sensitive to skew coefficients. Estimates of population skew for a site are improved when computed from the weighted average of (1) the sample (station) skew, and (2) an unbiased, generalized skew estimate. A weighting technique based on the number of years of record at each of 226 sites was used to develop a contour map of unbiased, generalized skew coefficients for New York. An attempt was made to group (regionalize) the station skew coefficients into five hydrologically similar areas of New York, but the statewide version proved to be as accurate as the regionalized version and therefore was adopted as the final generalized skew-coefficient map for New York. An error analysis showed the statewide contour map to have lower MSE?s (mean square errors) than those computed from (1) the five regional skewcoefficient contour maps, (2) a previously used (1982) nationwide skew coefficient map, and (3) the weighted mean of skew coefficients for sites within each of five hydrologically uniform, but distinct areas of New York.

  17. Modelling non-normal data: The relationship between the skew-normal factor model and the quadratic factor model.

    PubMed

    Smits, Iris A M; Timmerman, Marieke E; Stegeman, Alwin

    2016-05-01

    Maximum likelihood estimation of the linear factor model for continuous items assumes normally distributed item scores. We consider deviations from normality by means of a skew-normally distributed factor model or a quadratic factor model. We show that the item distributions under a skew-normal factor are equivalent to those under a quadratic model up to third-order moments. The reverse only holds if the quadratic loadings are equal to each other and within certain bounds. We illustrate that observed data which follow any skew-normal factor model can be so well approximated with the quadratic factor model that the models are empirically indistinguishable, and that the reverse does not hold in general. The choice between the two models to account for deviations of normality is illustrated by an empirical example from clinical psychology. PMID:26566696

  18. Skew orthogonal polynomials for the real and quaternion real Ginibre ensembles and generalizations

    NASA Astrophysics Data System (ADS)

    Forrester, Peter J.

    2013-06-01

    There are some distinguished ensembles of non-Hermitian random matrices for which the joint probability density function can be written down explicitly, are unchanged by rotations, and furthermore which have the property that the eigenvalues form a Pfaffian point process. For these ensembles, in which the elements of the matrices are either real, or real quaternion, the kernel of the Pfaffian is completely determined by certain skew orthogonal polynomials, which permit an expression in terms of averages over the characteristic polynomial, and the characteristic polynomial multiplied by the trace. We use Schur polynomial theory, knowledge of the value of a Schur polynomial averaged against real, and real quaternion Gaussian matrices, and the Selberg integral to evaluate these averages.

  19. A cylindrical shell with an axial crack under skew-symmetric loading.

    NASA Technical Reports Server (NTRS)

    Yuceoglu, U.; Erdogan, F.

    1973-01-01

    The skew-symmetric problem for a cylindrical shell containing an axial crack is considered. It is assumed that the material has a special orthotropy - namely, that the shear modulus may be evaluated from the measured Young's moduli and Poisson ratios and is not an independent material constant. The problem is solved within the confines of an eighth-order linearized shallow shell theory. As numerical examples, the torsion of an isotropic cylinder and that of a specially orthotropic cylinder (titanium) are considered. The membrane and bending components of the stress intensity factor are calculated and are given as functions of a dimensionless shell parameter. In the torsion problem for the axially cracked cylinder the bending effects appear to be much more significant than that found for the circumferentially cracked cylindrical shell. Also, as the shell parameter increases, unlike the results found in the pressurized shell, the bending stresses around crack ends do not change sign.

  20. Singly reflected skew rays inside a hollow tube: an exact cardiold solution for incident rim rays.

    PubMed

    Pike, J N

    1991-08-01

    Diffuse light entering a hollow cylindrical tube forms a manifold of concentric bright bands as a result of multiple internal reflections. A circular occulting stop, filling the entrance aperture except for a narrow rim annulus, converts these successive bands into sharply bounded rings, the first of which is produced solely by singly reflected skew and meridional rays. The exact geometrical optics of all rays emitted by any point on the rim are considered, and it is shown that after a single reflection all such rays appear to arise from a single cardioid curve. When rotated about the optic axis, this cardioid predicts the flaring ring intensity distribution observed. (Any departure of this first ring from concentricity around the direct image of the rim annulus provides a quantitative measure of nonstraightness of the tube.). PMID:20706383

  1. Extreme skewing of X chromosome inactivation in mothers of homosexual men.

    PubMed

    Bocklandt, Sven; Horvath, Steve; Vilain, Eric; Hamer, Dean H

    2006-02-01

    Human sexual preference is a sexually dimorphic trait with a substantial genetic component. Linkage of male sexual orientation to markers on the X chromosome has been reported in some families. Here, we measured X chromosome inactivation ratios in 97 mothers of homosexual men and 103 age-matched control women without gay sons. The number of women with extreme skewing of X-inactivation was significantly higher in mothers of gay men (13/97=13%) compared to controls (4/103=4%) and increased in mothers with two or more gay sons (10/44=23%). Our findings support a role for the X chromosome in regulating sexual orientation in a subgroup of gay men. PMID:16369763

  2. Shift Dependent Skew Quadrupole in Advanced Light SourceElliptically Polarizing Undulators, Cause and Corrections

    SciTech Connect

    Marks, Steve; Prestemon, Soren; Robin, David; Schlueter, Ross D.; Steier, Christoph; Wolski, Andrew; Jung, Jin-Young; Chubar, Oleg

    2005-11-29

    Three elliptically polarizing undulators (EPU) are installed and operational at the Advanced Light Source (ALS); the most recent was installed in April 2005. Operational experience has shown a variation in electron beam size which correlates with the EPU's magnetic quadrant shifts used to vary polarization. Storage ring electron dynamics studies pointed to the existence of a shift dependent skew quadrupole (SQ) component generated within the EPUs. Detailed magnetic and mechanical measurements demonstrated that the field errors were the result of systematic individual magnetic block displacements which vary with quadrant shift. This paper will discuss the results of electron dynamics studies, magnetic and mechanical measurements, design modifications planned for future EPUs to eliminate the SQ source, and the design and implementation of SQ compensation coils.

  3. The Modified Concorde Position with an Intraoperative Skew Head Rotation: Technical Note

    PubMed Central

    TAKASUNA, Hiroshi; TANAKA, Yuichiro

    2015-01-01

    The Concorde position was developed to approach pineal and cerebellar lesions with a midline suboccipital craniotomy. The neutral head position is needed to divide the occipital muscles symmetrically. The patient’s head is tilted to the right and the face is turned to the right for the microscopic procedure to keep the midline of the patient’s head axis straight in the surgical field for comfortable and accurate surgical manipulation. However, intraoperative repositioning of the patient’s head is somewhat difficult to release the holding arm of the Sugita head holder in the original method. We found that a skew head rotation by fixing the head asymmetrically in the Sugita head holder is very quick and convenient to obtain the optimal head position both for a craniotomy and a microscopic procedure. PMID:26226983

  4. Numeric and symbolic evaluation of the pfaffian of general skew-symmetric matrices

    NASA Astrophysics Data System (ADS)

    González-Ballestero, C.; Robledo, L. M.; Bertsch, G. F.

    2011-10-01

    Evaluation of pfaffians arises in a number of physics applications, and for some of them a direct method is preferable to using the determinantal formula. We discuss two methods for the numerical evaluation of pfaffians. The first is tridiagonalization based on Householder transformations. The main advantage of this method is its numerical stability that makes unnecessary the implementation of a pivoting strategy. The second method considered is based on Aitken's block diagonalization formula. It yields to a kind of LU (similar to Cholesky's factorization) decomposition (under congruence) of arbitrary skew-symmetric matrices that is well suited both for the numeric and symbolic evaluations of the pfaffian. Fortran subroutines (FORTRAN 77 and 90) implementing both methods are given. We also provide simple implementations in Python and Mathematica for purpose of testing, or for exploratory studies of methods that make use of pfaffians.

  5. Obliterable of graphics and correction of skew using Hough transform for mobile captured documents

    NASA Astrophysics Data System (ADS)

    Chethan, H. K.; Kumar, G. Hemantha

    2011-10-01

    CBDA is an emerging field in Computer Vision and Pattern Recognition. In recent technology camera are incorporated to several electronic equipments and are very interesting and thus playing a vital role by replacing scanner with hand held imaging devices like Digital Cameras, Mobile phones and gaming devices attached with these camera. The goal of the work is to remove graphics from the document which plays a vital role in recognition of characters from the mobile captured documents. In this paper we have proposed a novel method for separating or removal of graphics like logos, animations other than the text from the document and method to reduce noise and finally textual content skew is estimated and corrected using Hough Transform. The experimental results show the efficacy compared to the result of well known existing methods.

  6. CMOS open-fault detection in the presence of glitches and timing skews

    NASA Astrophysics Data System (ADS)

    Rajsuman, Rochit; Jayasumana, Anura P.; Malaiya, Yashwant K.

    1989-08-01

    A testable CMOS design technique in which some extra transistors are used in such a way that the CMOS gate is converted to a pseudo-nMOS/pMOS gate during testing is discussed. With the proposed design technique, CMOS open faults can be detected regardless of timing skews/delays, glitches, or charge sharing among the internal nodes. The major advantage of the proposed testable design technique is that it allows the use of a single test vector to detect a stuck-open fault. This significantly reduces the complexity of test generation and the time consumed for testing. The design procedure is simple and all the classical algorithms and automatic test-pattern-generating programs can be used to generate tests for circuits designed according to this technique. Even random testing techniques can be used efficiently to detect the open faults in these CMOS circuits.

  7. A Novel Generalized Normal Distribution for Human Longevity and other Negatively Skewed Data

    PubMed Central

    Robertson, Henry T.; Allison, David B.

    2012-01-01

    Negatively skewed data arise occasionally in statistical practice; perhaps the most familiar example is the distribution of human longevity. Although other generalizations of the normal distribution exist, we demonstrate a new alternative that apparently fits human longevity data better. We propose an alternative approach of a normal distribution whose scale parameter is conditioned on attained age. This approach is consistent with previous findings that longevity conditioned on survival to the modal age behaves like a normal distribution. We derive such a distribution and demonstrate its accuracy in modeling human longevity data from life tables. The new distribution is characterized by 1. An intuitively straightforward genesis; 2. Closed forms for the pdf, cdf, mode, quantile, and hazard functions; and 3. Accessibility to non-statisticians, based on its close relationship to the normal distribution. PMID:22623974

  8. Ultra-High Energy Cosmic Rays: Composition, Early Air Shower Interactions, and Xmax Skewness

    NASA Astrophysics Data System (ADS)

    Stapleton, James

    The composition of Ultra-High Energy Cosmic Rays (UHECRs) is still not completely understood, and must be inferred from Extended Air Shower (EAS), particle cascades which they initiate upon entering the atmosphere. The atmospheric depth at which the shower contains the maximum number of particles ( Xmax) is the most composition-sensitive property of the air shower, but its interpretation is hindered by intrinsic statistical fluctuations in EAS development which cause distinct compositions to produce overlapping Xmax distributions as well as our limited knowledge at these energies of hadronic physics which strongly impacts the Xmax distribution's shape. These issues ultimately necessitate a variety of complementary approaches to interpreting UHECR composition from Xmax data. The current work advances these approaches by connecting X max skewness to the uncertainties above. The study of X max has historically focused only on the mean and standard deviation of its distribution, but skewness is shown here to be strongly related to both the statistical fluctuations in EAS development as well as the least-understood hadronic cross-sections in the air shower. This leads into a treatment of the Exponentially-Modified Gaussian (EMG) distribution, whose little-known properties make it very useful for Xmax analysis and for data analysis in general. A powerful method emerges which uses only descriptive statistics in a robust check for energy-dependent changes in UHECR mass or EAS development. The application of these analyses to X max data provides tantalizing clues concerning issues of critical importance, such as the relationship between Xmax and the 'ankle' break in the UHECR energy spectrum, or the inferred properties of the UHECR mass distribution and its strong dependence on hadronic model systematics.

  9. Th1-skewed tissue responses to a mycolyl glycolipid in mycobacteria-infected rhesus macaques

    SciTech Connect

    Morita, Daisuke; Miyamoto, Ayumi; Hattori, Yuki; Komori, Takaya; Nakamura, Takashi; Igarashi, Tatsuhiko; Harashima, Hideyoshi; Sugita, Masahiko

    2013-11-08

    Highlights: •Glucose monomycolate (GMM) is a marker glycolipid for active tuberculosis. •Tissue responses to GMM involved up-regulation of Th1-attracting chemokines. •Th1-skewed local responses were mounted at the GMM-injected tissue. -- Abstract: Trehalose 6,6′-dimycolate (TDM) is a major glycolipid of the cell wall of mycobacteria with remarkable adjuvant functions. To avoid detection by the host innate immune system, invading mycobacteria down-regulate the expression of TDM by utilizing host-derived glucose as a competitive substrate for their mycolyltransferases; however, this enzymatic reaction results in the concomitant biosynthesis of glucose monomycolate (GMM) which is recognized by the acquired immune system. GMM-specific, CD1-restricted T cell responses have been detected in the peripheral blood of infected human subjects and monkeys as well as in secondary lymphoid organs of small animals, such as guinea pigs and human CD1-transgenic mice. Nevertheless, it remains to be determined how tissues respond at the site where GMM is produced. Here we found that rhesus macaques vaccinated with Mycobacterium bovis bacillus Calmette–Guerin mounted a chemokine response in GMM-challenged skin that was favorable for recruiting T helper (Th)1 T cells. Indeed, the expression of interferon-γ, but not Th2 or Th17 cytokines, was prominent in the GMM-injected tissue. The GMM-elicited tissue response was also associated with the expression of monocyte/macrophage-attracting CC chemokines, such as CCL2, CCL4 and CCL8. Furthermore, the skin response to GMM involved the up-regulated expression of granulysin and perforin. Given that GMM is produced primarily by pathogenic mycobacteria proliferating within the host, the Th1-skewed tissue response to GMM may function efficiently at the site of infection.

  10. A missing model in reproductive skew theory: the bordered tug-of-war.

    PubMed

    Reeve, Hudson Kern; Shen, Sheng-Feng

    2006-05-30

    Models of reproductive skew can be classified into two groups: transactional models, in which group members yield shares of reproduction to each other in return for cooperation, and tug-of-war models, in which group members invest group resources in a tug-of-war over their respective reproductive shares. We synthesize these two models to yield a "bordered tug-of-war" model in which the internal tug-of-war is limited ("bordered") by the requirement that group members must achieve a certain amount of reproduction lest they pursue a noncooperative option leading to group breakup. Previous attempts to synthesize these two models did not allow for the fact that the tug-of-war will affect group output, which in turn feeds back on the reproductive payments required by group members to remain cooperative. The bordered tug-of-war model, which does not assume complete reproductive control by any individual and allows for conflict within groups, predicts that the degree of within-group selfishness will increase as the noncooperative options become less attractive, e.g., as ecological constraints on solitary breeding increase. When the noncooperative option involves fighting for the group resource (e.g., territory) and leaving if the fight is lost, the subordinate's overall share of reproduction is predicted to be independent of its relatedness to the dominant and to increase the greater its probability of winning the fight, the less the value of the territory, and the greater its personal payoff for leaving. The unique predictions of the bordered tug-of-war model may fit skew data from a number of species, including meerkats, lions, and wood mice. PMID:16717185

  11. Resonance multiphoton ionization and dissociation of dimethyl ether via the {\\skew1\\tilde{\\rm C}^{\\prime}}, {\\skew1\\tilde{\\rm C}} and \\tilde{\\rm B} states

    NASA Astrophysics Data System (ADS)

    Mejia-Ospino, E.; García, G.; Guerrero, A.; Alvarez, I.; Cisneros, C.

    2005-01-01

    The three-photon resonance four-photon ionization and dissociation spectra of dimethyl ether (DME) are presented in the wavelength range 450-550 nm at 1 nm intervals. The (3+1) REMPI spectra show three prominent bands corresponding to the \\tildeB \\leftarrow \\skew1\\tildeX, {\\skew1\\tildeC} \\leftarrow \\skew1\\tildeX and {\\skew1\\tildeC^{\\prime}} \\leftarrow \\skew1\\tildeX transitions with origins at 61 457 cm-1 (7.615 eV), 59 055 cm-1 (7.322 eV) and 58 010 cm-1 (7.194 eV), respectively. Several ionized species, CH3+, CHnO+ (n = 1-3) and CH3OCH3+, are observed in the region of wavelengths studied here. In order to compare the results, a shorter wavelength multiphoton dissociation and ionization of DME at 355 nm is also presented. At this wavelength, DME undergoes neutral dissociation to CH3 and CH3O and each fragment is then ionized by multiphoton absorption. The fragmentation at 355 nm is very intense and only small fragments such as CH3+, CHO+, CH2+, CH+ and C+ ions are observed. The measurement of photoelectron energy allows us to establish that the DME ionization potential is at least 9.55 ± 0.15 eV. The experiments were performed using a Nd:YAG-OPO (optical parametric oscillator) tunable laser system coupled to a time-of-flight mass spectrometer and a hemispherical electron energy analyser.

  12. Social Justice and South African University Student Enrolment Data by "Race", 1998-2012: From "Skewed Revolution" to "Stalled Revolution"

    ERIC Educational Resources Information Center

    Cooper, David

    2015-01-01

    The paper looks closely at student enrolment trends through a case study of South African "race" enrolment data, including some hypotheses about how student social class has influenced these trends. First, data on 1988-1998 enrolments showing a "skewed revolution" in student africanisation are summarised. Then, using 2000-2012…

  13. Estimation of the radionuclide transport by applying the mean, the standard deviation and the skewness of permeability

    SciTech Connect

    Niibori, Y.; Tochiyama, O.; Chida, T.

    1997-12-31

    The authors have investigated the characteristic permeability on the basis of some probability density functions of permeability, applying the Monte Carlo method and FEM. It was found that its value does not depend on type of probability density function of permeability, but on the arithmetic mean, the standard deviation and the skewness of permeability. This paper describes the use of the stochastic values of permeability for estimating the rate of radioactivity release to the accessible environment, applying the advection-dispersion model to two-dimensional, heterogeneous media. When a discrete probability density function (referred to as the Bernoulli trials) and the lognormal distribution have common values for the arithmetic mean, the standard deviation and the skewness of permeability, the calculated transport rates (described as the pseudo impulse responses) show good agreements for Peclet number around 10 and the dimensionless standard deviation around 1. Further, it is found that the transport rates apparently depends not only on the arithmetic mean and the standard deviation, but also on the skewness of permeability. When the value of skewness does not follow the lognormal distribution which has only two independent parameters (the mean and the standard deviation), the authors can replicate the three moments estimated from an observed distribution of permeability, by using the Bernoulli trials having three independent parameters.

  14. Determining the role of skewed X-chromosome inactivation in developing muscle symptoms in carriers of Duchenne muscular dystrophy.

    PubMed

    Viggiano, Emanuela; Ergoli, Manuela; Picillo, Esther; Politano, Luisa

    2016-07-01

    Duchenne and Becker dystrophinopathies (DMD and BMD) are X-linked recessive disorders caused by mutations in the dystrophin gene that lead to absent or reduced expression of dystrophin in both skeletal and heart muscles. DMD/BMD female carriers are usually asymptomatic, although about 8 % may exhibit muscle or cardiac symptoms. Several mechanisms leading to a reduced dystrophin have been hypothesized to explain the clinical manifestations and, in particular, the role of the skewed XCI is questioned. In this review, the mechanism of XCI and its involvement in the phenotype of BMD/DMD carriers with both a normal karyotype or with X;autosome translocations with breakpoints at Xp21 (locus of the DMD gene) will be analyzed. We have previously observed that DMD carriers with moderate/severe muscle involvement, exhibit a moderate or extremely skewed XCI, in particular if presenting with an early onset of symptoms, while DMD carriers with mild muscle involvement present a random XCI. Moreover, we found that among 87.1 % of the carriers with X;autosome translocations involving the locus Xp21 who developed signs and symptoms of dystrophinopathy such as proximal muscle weakness, difficulty to run, jump and climb stairs, 95.2 % had a skewed XCI pattern in lymphocytes. These data support the hypothesis that skewed XCI is involved in the onset of phenotype in DMD carriers, the X chromosome carrying the normal DMD gene being preferentially inactivated and leading to a moderate-severe muscle involvement. PMID:27098336

  15. On the Empirical Importance of the Conditional Skewness Assumption in Modelling the Relationship between Risk and Return

    NASA Astrophysics Data System (ADS)

    Pipień, M.

    2008-09-01

    We present the results of an application of Bayesian inference in testing the relation between risk and return on the financial instruments. On the basis of the Intertemporal Capital Asset Pricing Model, proposed by Merton we built a general sampling distribution suitable in analysing this relationship. The most important feature of our assumptions is that the skewness of the conditional distribution of returns is used as an alternative source of relation between risk and return. This general specification relates to Skewed Generalized Autoregressive Conditionally Heteroscedastic-in-Mean model. In order to make conditional distribution of financial returns skewed we considered the unified approach based on the inverse probability integral transformation. In particular, we applied hidden truncation mechanism, inverse scale factors, order statistics concept, Beta and Bernstein distribution transformations and also a constructive method. Based on the daily excess returns on the Warsaw Stock Exchange Index we checked the empirical importance of the conditional skewness assumption on the relation between risk and return on the Warsaw Stock Market. We present posterior probabilities of all competing specifications as well as the posterior analysis of the positive sign of the tested relationship.

  16. Analysis and Investigation of Skew Effect on Behavior and Performance of a Small Scale Three-Phase Self-Excited Induction Generator

    NASA Astrophysics Data System (ADS)

    Sawetsakulanond, Budhapon; Kinnares, Vijit

    This paper presents analysis and investigation of the skew effect on behavior and performance of a three-phase, 220/380V, 8.7/5.0A, Δ/Y connected, 4 poles, 2.2kW self-excited induction generator (SEIG) with different angles rotor skewing. A 2D finite element analysis (2D-FEA) is used to consider core loss, flux density and circuit parameters. Analysis of excitation capacitor values for the SEIG based on a steady-state equivalent circuit model including rotor skew effect is given. Skewed rotor slots with angle of 0° (non-skew), 5° and 10° for the SEIGs are employed. Testing and performance comparisons under steady-state operation with a pure resistive load have been conducted. Obtained results can be guidelines and recommendations for development of effective wind induction generators.

  17. Bayesian WLS/GLS regression for regional skewness analysis for regions with large crest stage gage networks

    USGS Publications Warehouse

    Veilleux, Andrea G.; Stedinger, Jery R.; Eash, David A.

    2012-01-01

    This paper summarizes methodological advances in regional log-space skewness analyses that support flood-frequency analysis with the log Pearson Type III (LP3) distribution. A Bayesian Weighted Least Squares/Generalized Least Squares (B-WLS/B-GLS) methodology that relates observed skewness coefficient estimators to basin characteristics in conjunction with diagnostic statistics represents an extension of the previously developed B-GLS methodology. B-WLS/B-GLS has been shown to be effective in two California studies. B-WLS/B-GLS uses B-WLS to generate stable estimators of model parameters and B-GLS to estimate the precision of those B-WLS regression parameters, as well as the precision of the model. The study described here employs this methodology to develop a regional skewness model for the State of Iowa. To provide cost effective peak-flow data for smaller drainage basins in Iowa, the U.S. Geological Survey operates a large network of crest stage gages (CSGs) that only record flow values above an identified recording threshold (thus producing a censored data record). CSGs are different from continuous-record gages, which record almost all flow values and have been used in previous B-GLS and B-WLS/B-GLS regional skewness studies. The complexity of analyzing a large CSG network is addressed by using the B-WLS/B-GLS framework along with the Expected Moments Algorithm (EMA). Because EMA allows for the censoring of low outliers, as well as the use of estimated interval discharges for missing, censored, and historic data, it complicates the calculations of effective record length (and effective concurrent record length) used to describe the precision of sample estimators because the peak discharges are no longer solely represented by single values. Thus new record length calculations were developed. The regional skewness analysis for the State of Iowa illustrates the value of the new B-WLS/BGLS methodology with these new extensions.

  18. NPIP: A skew line needle configuration optimization system for HDR brachytherapy

    SciTech Connect

    Siauw, Timmy; Cunha, Adam; Berenson, Dmitry; Atamtuerk, Alper; Hsu, I-Chow; Goldberg, Ken; Pouliot, Jean

    2012-07-15

    Purpose: In this study, the authors introduce skew line needle configurations for high dose rate (HDR) brachytherapy and needle planning by integer program (NPIP), a computational method for generating these configurations. NPIP generates needle configurations that are specific to the anatomy of the patient, avoid critical structures near the penile bulb and other healthy structures, and avoid needle collisions inside the body. Methods: NPIP consisted of three major components: a method for generating a set of candidate needles, a needle selection component that chose a candidate needle subset to be inserted, and a dose planner for verifying that the final needle configuration could meet dose objectives. NPIP was used to compute needle configurations for prostate cancer data sets from patients previously treated at our clinic. NPIP took two user-parameters: a number of candidate needles, and needle coverage radius, {delta}. The candidate needle set consisted of 5000 needles, and a range of {delta} values was used to compute different needle configurations for each patient. Dose plans were computed for each needle configuration. The number of needles generated and dosimetry were analyzed and compared to the physician implant. Results: NPIP computed at least one needle configuration for every patient that met dose objectives, avoided healthy structures and needle collisions, and used as many or fewer needles than standard practice. These needle configurations corresponded to a narrow range of {delta} values, which could be used as default values if this system is used in practice. The average end-to-end runtime for this implementation of NPIP was 286 s, but there was a wide variation from case to case. Conclusions: The authors have shown that NPIP can automatically generate skew line needle configurations with the aforementioned properties, and that given the correct input parameters, NPIP can generate needle configurations which meet dose objectives and use as many

  19. ON THE NONRELATIVISTIC ORIGIN OF RED-SKEWED IRON LINES IN CATACLYSMIC VARIABLE, NEUTRON STAR, AND BLACK HOLE SOURCES

    SciTech Connect

    Titarchuk, Lev; Laurent, Philippe E-mail: plaurent@cea.fr

    2009-08-01

    We perform the analysis of the iron K{sub {alpha}} lines detected in three sources representing three types of accreting compact sources: cataclysmic variable (CV) GK Per, neutron star (NS) Serpens X-1, and black hole (BH) GX 339-4. We find, using data from Epic-PN Camera onboard XMM-Newton observatory, that the iron K{sub {alpha}} emission line in GK Per has a noticeable red-skewed profile. We compare the GK Per asymmetric line with the red-skewed lines observed by XMM-Newton in Serpens X-1 and GX 339-4. The observation of the K{sub {alpha}} emission with red-skewed features in CV GK Per cannot be related to the redshift effects of General Relativity (GR). Therefore, if the mechanism of the K{sub {alpha}}-line formation is the same in CVs, NSs, and BHs then it is evident that the GR effects would be ruled out as a cause of red skewness of K{sub {alpha}} line. The line reprocessing in an outflowing wind has been recently suggested as an alternative model for a broad red-shifted iron line formation. In the framework of the outflow scenario the red-skewed iron line is formed in the strong extended wind due to its illumination by the radiation emanating from the innermost part of the accreting material. The outflow is a common phenomenon for CVs, NSs, and BHs. In this paper, we demonstrate that the asymmetric shapes of the lines detected from these CV, NS, and BH sources are well described with the wind (outflow) model. Furthermore we find by analyzing Rossi X-Ray Timing Explorer(RXTE) observations that when the strong red-skewed iron line is observed in GX 339-4 the high-frequency variability is strongly suppressed. While this fact is hard to reconcile with the relativistic models, it is consistent with the outflowing gas washing out high-frequency modulations of the radiation presumably originated in the innermost part of the source.

  20. Application of derivative matrices of skew rays to design of compound dispersion prisms.

    PubMed

    Lin, Psang Dain

    2016-09-01

    Numerous optimization methods have been developed in recent decades for optical system design. However, these methods rely heavily on ray tracing and finite difference techniques to estimate the derivative matrices of the rays. Consequently, the accuracy of the results obtained from these methods is critically dependent on the incremental step size used in the tuning stage. To overcome this limitation, the present study proposes a comprehensive methodology for the design of compound dispersion prisms based on the first- and second-order derivative matrices of skew rays. The proposed method facilitates the analysis and design of prisms with respect to arbitrary system variables and provides an ideal basis for automatic prism design applications. Four illustrative examples are given. It is shown that the optical quantities required to evaluate the prism performance can be extracted directly from the proposed derivative matrices. In addition, it is shown in this study that the single-element 3D prism can have the same deviation angle and spectral dispersion as the 2D compound prism. PMID:27607509

  1. Properties of the Subantarctic Front and Polar Front from the skewness of sea level anomaly

    NASA Astrophysics Data System (ADS)

    Shao, Andrew E.; Gille, Sarah T.; Mecking, Sabine; Thompson, LuAnne

    2015-07-01

    The region of the Southern Ocean that encompasses the Subantarctic Front (SAF) to the north and the Polar Front (PF) to the south contains most of the transport of the Antarctic Circumpolar Current. Here skewness of sea level anomaly (SLA) from 1992 to 2013 is coupled with a meandering Gaussian jetw model to estimate the mean position, meridional width, and the percent variance that each front contributes to total SLA variability. The SAF and PF have comparable widths (85 km) in the circumpolar average, but their widths differ significantly in the East Pacific Basin (85 and 60 km, respectively). Interannual variability in the positions of the SAF and PF are also estimated using annual subsets of the SLA data from 1993 to 2012. The PF position has enhanced variability near strong topographic features such as the Kerguelen Plateau, the Campbell Plateau east of New Zealand, and downstream of Drake Passage. Neither the SAF nor the PF showed a robust meridional trend over the 20 year period. The Southern Annular Mode was significantly correlated with basin-averaged SAF and PF positions in the East Pacific and with the PF south of Australia. A correlation between the PF and the basin-scale wind stress curl anomaly was also found in the western extratropical Pacific but not in other basins.

  2. Bayesian linear regression with skew-symmetric error distributions with applications to survival analysis.

    PubMed

    Rubio, Francisco J; Genton, Marc G

    2016-06-30

    We study Bayesian linear regression models with skew-symmetric scale mixtures of normal error distributions. These kinds of models can be used to capture departures from the usual assumption of normality of the errors in terms of heavy tails and asymmetry. We propose a general noninformative prior structure for these regression models and show that the corresponding posterior distribution is proper under mild conditions. We extend these propriety results to cases where the response variables are censored. The latter scenario is of interest in the context of accelerated failure time models, which are relevant in survival analysis. We present a simulation study that demonstrates good frequentist properties of the posterior credible intervals associated with the proposed priors. This study also sheds some light on the trade-off between increased model flexibility and the risk of over-fitting. We illustrate the performance of the proposed models with real data. Although we focus on models with univariate response variables, we also present some extensions to the multivariate case in the Supporting Information. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26856806

  3. Dynamics of ferromagnetic spin glass: randomly canted ferromagnet versus skewed spin glass

    NASA Astrophysics Data System (ADS)

    Janutka, Andrzej

    2003-12-01

    A ferromagnetic spin glass (FSG) is one of the three isotropic and homogeneous phases of the long-range partially ordered magnets with spin and atomic disorder which are selected by symmetry (Andreev 1978 Sov. Phys.—JETP 47 411) (the others are genuine and antiferromagnetic spin glasses). The linear dynamical response to a magnetic field of two sub-phases of a FSG with drastically different dynamics, a randomly canted ferromagnet, in which the component spins create an acute angle with the summary magnetic moment, and a less-ordered skewed spin glass is analysed in the spin-wave approximation in the framework of phenomenological theory. The spin-wave damping coefficients and frequency shifts due to a magnon-magnon interaction are evaluated as functions of temperature and wavevector as well as the spectral-weight functions of the linear response to a magnetic field and the neutron scattering cross section which provides the possibility for experimental verification of the results. Substantial differences in the spin-wave characteristics of the FSG compared to those of the Heisenberg spin glass and the Heisenberg ferromagnet are found to be due to non-linear anisotropy effects in a FSG.

  4. Zinc Induces Dendritic Cell Tolerogenic Phenotype and Skews Regulatory T Cell-Th17 Balance.

    PubMed

    George, Mariam Mathew; Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Caruso, Joseph A; Deepe, George S

    2016-09-01

    Zinc (Zn) is an essential metal for development and maintenance of both the innate and adaptive compartments of the immune system. Zn homeostasis impacts maturation of dendritic cells (DCs) that are important in shaping T cell responses. The mechanisms by which Zn regulates the tolerogenic phenotype of DCs remain largely unknown. In this study, we investigated the effect of Zn on DC phenotype and the generation of Foxp3(+) regulatory T cells (Tregs) using a model of Histoplasma capsulatum fungal infection. Exposure of bone marrow-derived DCs to Zn in vitro induced a tolerogenic phenotype by diminishing surface MHC class II (MHCII) and promoting the tolerogenic markers, programmed death-ligand (PD-L)1, PD-L2, and the tryptophan degrading enzyme, IDO. Zn triggered tryptophan degradation by IDO and kynurenine production by DCs and strongly suppressed the proinflammatory response to stimulation by TLR ligands. In vivo, Zn supplementation and subsequent H. capsulatum infection supressed MHCII on DCs, enhanced PD-L1 and PD-L2 expression on MHCII(lo) DCs, and skewed the Treg-Th17 balance in favor of Foxp3(+) Tregs while decreasing Th17 cells. Thus, Zn shapes the tolerogenic potential of DCs in vitro and in vivo and promotes Tregs during fungal infection. PMID:27465530

  5. A Timing Estimation Method Based-on Skewness Analysis in Vehicular Wireless Networks

    PubMed Central

    Cui, Xuerong; Li, Juan; Wu, Chunlei; Liu, Jian-Hang

    2015-01-01

    Vehicle positioning technology has drawn more and more attention in vehicular wireless networks to reduce transportation time and traffic accidents. Nowadays, global navigation satellite systems (GNSS) are widely used in land vehicle positioning, but most of them are lack precision and reliability in situations where their signals are blocked. Positioning systems base-on short range wireless communication are another effective way that can be used in vehicle positioning or vehicle ranging. IEEE 802.11p is a new real-time short range wireless communication standard for vehicles, so a new method is proposed to estimate the time delay or ranges between vehicles based on the IEEE 802.11p standard which includes three main steps: cross-correlation between the received signal and the short preamble, summing up the correlated results in groups, and finding the maximum peak using a dynamic threshold based on the skewness analysis. With the range between each vehicle or road-side infrastructure, the position of neighboring vehicles can be estimated correctly. Simulation results were presented in the International Telecommunications Union (ITU) vehicular multipath channel, which show that the proposed method provides better precision than some well-known timing estimation techniques, especially in low signal to noise ratio (SNR) environments. PMID:26580628

  6. Skew of mantle upwelling beneath the East Pacific Rise governs segmentation.

    PubMed

    Toomey, Douglas R; Jousselin, David; Dunn, Robert A; Wilcock, William S D; Detrick, R S

    2007-03-22

    Mantle upwelling is essential to the generation of new oceanic crust at mid-ocean ridges, and it is generally assumed that such upwelling is symmetric beneath active ridges. Here, however, we use seismic imaging to show that the isotropic and anisotropic structure of the mantle is rotated beneath the East Pacific Rise. The isotropic structure defines the pattern of magma delivery from the mantle to the crust. We find that the segmentation of the rise crest between transform faults correlates well with the distribution of mantle melt. The azimuth of seismic anisotropy constrains the direction of mantle flow, which is rotated nearly 10 degrees anticlockwise from the plate-spreading direction. The mismatch between the locus of mantle melt delivery and the morphologic ridge axis results in systematic differences between areas of on-axis and off-axis melt supply. We conclude that the skew of asthenospheric upwelling and transport governs segmentation of the East Pacific Rise and variations in the intensity of ridge crest processes. PMID:17377578

  7. GC skew defines distinct RNA polymerase pause sites in CpG island promoters.

    PubMed

    Kellner, Wendy A; Bell, Joshua S K; Vertino, Paula M

    2015-11-01

    CpG islands (CGIs) are associated with over half of human gene promoters and are characterized by a unique chromatin environment and high levels of bidirectional transcriptional activity relative to surrounding genomic regions, suggesting that RNA polymerase (Pol II) progression past the CGI boundaries is restricted. Here we describe a novel transcriptional regulatory step wherein Pol II encounters an additional barrier to elongation distinct from the promoter-proximal pause and occurring at the downstream boundary of the CGI domain. For most CGI-associated promoters, Pol II exhibits a dominant pause at either the promoter-proximal or this distal site that correlates, both in position and in intensity, with local regions of high GC skew, a sequence feature known to form unique secondary structures. Upon signal-induced gene activation, long-range enhancer contacts at the dominant pause site are selectively enhanced, suggesting a new role for enhancers at the downstream pause. These data point to an additional level of control over transcriptional output at a subset of CGI-associated genes that is linked to DNA sequence and the integrity of the CGI domain. PMID:26275623

  8. Viruses-to-mobile genetic elements skew in the deep Atlantis II brine pool sediments.

    PubMed

    Adel, Mustafa; Elbehery, Ali H A; Aziz, Sherry K; Aziz, Ramy K; Grossart, Hans-Peter; Siam, Rania

    2016-01-01

    The central rift of the Red Sea has 25 brine pools with different physical and geochemical characteristics. Atlantis II (ATIID), Discovery Deeps (DD) and Chain Deep (CD) are characterized by high salinity, temperature and metal content. Several studies reported microbial communities in these brine pools, but few studies addressed the brine pool sediments. Therefore, sediment cores were collected from ATIID, DD, CD brine pools and an adjacent brine-influenced site. Sixteen different lithologic sediment sections were subjected to shotgun DNA pyrosequencing to generate 1.47 billion base pairs (1.47 × 10(9) bp). We generated sediment-specific reads and attempted to annotate all reads. We report the phylogenetic and biochemical uniqueness of the deepest ATIID sulfur-rich brine pool sediments. In contrary to all other sediment sections, bacteria dominate the deepest ATIID sulfur-rich brine pool sediments. This decrease in virus-to-bacteria ratio in selected sections and depth coincided with an overrepresentation of mobile genetic elements. Skewing in the composition of viruses-to-mobile genetic elements may uniquely contribute to the distinct microbial consortium in sediments in proximity to hydrothermally active vents of the Red Sea and possibly in their surroundings, through differential horizontal gene transfer. PMID:27596223

  9. Failure detection and isolation investigation for strapdown skew redundant tetrad laser gyro inertial sensor arrays

    NASA Technical Reports Server (NTRS)

    Eberlein, A. J.; Lahm, T. G.

    1976-01-01

    The degree to which flight-critical failures in a strapdown laser gyro tetrad sensor assembly can be isolated in short-haul aircraft after a failure occurrence has been detected by the skewed sensor failure-detection voting logic is investigated along with the degree to which a failure in the tetrad computer can be detected and isolated at the computer level, assuming a dual-redundant computer configuration. The tetrad system was mechanized with two two-axis inertial navigation channels (INCs), each containing two gyro/accelerometer axes, computer, control circuitry, and input/output circuitry. Gyro/accelerometer data is crossfed between the two INCs to enable each computer to independently perform the navigation task. Computer calculations are synchronized between the computers so that calculated quantities are identical and may be compared. Fail-safe performance (identification of the first failure) is accomplished with a probability approaching 100 percent of the time, while fail-operational performance (identification and isolation of the first failure) is achieved 93 to 96 percent of the time.

  10. Net-proton-number kurtosis and skewness in nuclear collisions: Influence of deuteron formation

    NASA Astrophysics Data System (ADS)

    Fecková, Zuzana; Steinheimer, Jan; Tomášik, Boris; Bleicher, Marcus

    2015-12-01

    We explore the influence of deuteron formation in the late stage of nucleus-nucleus reactions on the fluctuations observed in the final net-proton yields around midrapidity. At each investigated energy, the produced (anti)proton yield at chemical freeze-out is assumed to fluctuate according to a Poisson distribution and in each event the probability for deuteron formation by coalescence is proportional to (dNproton/d y ) 2. The protons that are then clustered in deuterons are usually not included in the experimental measurement of the net-proton fluctuations, therefore, we subtract these clustered protons from the final state proton number for the calculation of the net-proton fluctuations (the same is done in the antiproton sector). Due to the nonlinear deuteron formation probability the resulting distribution is not a Skellam distribution, but shows the interesting feature of a decrease in the kurtosis κ σ2 and a local maximum in the skewness S σ observables as the collision energy decreases.

  11. A Timing Estimation Method Based-on Skewness Analysis in Vehicular Wireless Networks.

    PubMed

    Cui, Xuerong; Li, Juan; Wu, Chunlei; Liu, Jian-Hang

    2015-01-01

    Vehicle positioning technology has drawn more and more attention in vehicular wireless networks to reduce transportation time and traffic accidents. Nowadays, global navigation satellite systems (GNSS) are widely used in land vehicle positioning, but most of them are lack precision and reliability in situations where their signals are blocked. Positioning systems base-on short range wireless communication are another effective way that can be used in vehicle positioning or vehicle ranging. IEEE 802.11p is a new real-time short range wireless communication standard for vehicles, so a new method is proposed to estimate the time delay or ranges between vehicles based on the IEEE 802.11p standard which includes three main steps: cross-correlation between the received signal and the short preamble, summing up the correlated results in groups, and finding the maximum peak using a dynamic threshold based on the skewness analysis. With the range between each vehicle or road-side infrastructure, the position of neighboring vehicles can be estimated correctly. Simulation results were presented in the International Telecommunications Union (ITU) vehicular multipath channel, which show that the proposed method provides better precision than some well-known timing estimation techniques, especially in low signal to noise ratio (SNR) environments. PMID:26580628

  12. GC skew defines distinct RNA polymerase pause sites in CpG island promoters

    PubMed Central

    Kellner, Wendy A.; Bell, Joshua S.K.; Vertino, Paula M.

    2015-01-01

    CpG islands (CGIs) are associated with over half of human gene promoters and are characterized by a unique chromatin environment and high levels of bidirectional transcriptional activity relative to surrounding genomic regions, suggesting that RNA polymerase (Pol II) progression past the CGI boundaries is restricted. Here we describe a novel transcriptional regulatory step wherein Pol II encounters an additional barrier to elongation distinct from the promoter-proximal pause and occurring at the downstream boundary of the CGI domain. For most CGI-associated promoters, Pol II exhibits a dominant pause at either the promoter-proximal or this distal site that correlates, both in position and in intensity, with local regions of high GC skew, a sequence feature known to form unique secondary structures. Upon signal-induced gene activation, long-range enhancer contacts at the dominant pause site are selectively enhanced, suggesting a new role for enhancers at the downstream pause. These data point to an additional level of control over transcriptional output at a subset of CGI-associated genes that is linked to DNA sequence and the integrity of the CGI domain. PMID:26275623

  13. SIU-based modification in Kelley's measure of skewness to achieve gains in efficiency

    NASA Astrophysics Data System (ADS)

    Habibullah, Saleha Naghmi; Shan-E-Fatima, Syeda

    2015-02-01

    The importance of accurate modeling of life-lengths of components and systems cannot be over-emphasized. Some well-known distributions such as the Birnbaum Saunders distribution extensively used in Reliability Theory are known to fulfill the self-inversion property, the term `Self-Inverse at Unity' (`SIU') implying that, for a random variable X, the distribution of 1/ X is identical to the distribution of X. Very recently, it has been demonstrated the advantage that can be drawn from the SIU property by proposing a modification to the well-known formula of the empirical cumulative distribution function to obtain an estimator of the cumulative distribution function that is more efficient than the empirical cumulative distribution function in situations where the parent population can be assumed to be SIU. Subsequently, a number of papers have appeared proposing SIU-based modifications to the formulae of well-known estimators of central tendency, dispersion and kurtosis that are likely to yield gains in efficiency on account of an approach very similar to the one adopted for the modification of the formula of the empirical cumulative distribution function. In this paper, we propose SIU-based modification to Kelley's Measure of Skewness and, through a simulation study, demonstrate the potential of the proposed formula in improving the efficiency of the estimation process which, obviously, has important implications for accurate modeling of life-data encountered in various branches of engineering.

  14. Allele-Skewed DNA Modification in the Brain: Relevance to a Schizophrenia GWAS.

    PubMed

    Gagliano, Sarah A; Ptak, Carolyn; Mak, Denise Y F; Shamsi, Mehrdad; Oh, Gabriel; Knight, Joanne; Boutros, Paul C; Petronis, Arturas

    2016-05-01

    Numerous recent studies have suggested that phenotypic effects of DNA sequence variants can be mediated or modulated by their epigenetic marks, such as allele-skewed DNA modification (ASM). Using Affymetrix SNP microarrays, we performed a comprehensive search of ASM effects in human post-mortem brain and sperm samples (total n = 256) from individuals with major psychosis and control individuals. Depending on the phenotypic category of the brain samples, 1.4%-7.5% of interrogated SNPs exhibited ASM effects. Next, we investigated ASM in the context of genetic studies of schizophrenia and detected that brain ASM SNPs were significantly overrepresented among sub-threshold SNPs from a schizophrenia genome-wide association study (GWAS). Brain ASM SNPs showed a much stronger enrichment in a schizophrenia GWAS than in 17 large GWASs of non-psychiatric diseases and traits, arguing that ASM effects are at least partially tissue specific. Studies of germline and control brain ASM SNPs supported a causal association between ASM and schizophrenia. Finally, significantly higher proportions of ASM SNPs than of non-ASM SNPs were detected at loci exhibiting epigenetic signatures of enhancers and promoters, and they were overrepresented within transcription factor binding regions and DNase I hypersensitive sites. All of these findings collectively indicate that ASM SNPs should be prioritized in follow-up GWASs. PMID:27087318

  15. Skewed Riskscapes and Gentrified Inequities: Environmental Exposure Disparities in Seattle, Washington

    PubMed Central

    White, Jonah

    2011-01-01

    Objectives. Few studies have considered the sociohistorical intersection of environmental injustice and gentrification; a gap addressed by this case study of Seattle, Washington. This study explored the advantages of integrating air toxic risk screening with gentrification research to enhance proximity and health equity analysis methodologies. It was hypothesized that Seattle's industrial air toxic exposure risk was unevenly dispersed, that gentrification stratified the city's neighborhoods, and that the inequities of both converged. Methods. Spatial characterizations of air toxic pollution risk exposures from 1990 to 2007 were combined with longitudinal cluster analysis of census block groups in Seattle, Washington, from 1990 to 2000. Results. A cluster of air toxic exposure inequality and socioeconomic inequity converged in 1 area of south central Seattle. Minority and working class residents were more concentrated in the same neighborhoods near Seattle's worst industrial pollution risks. Conclusions. Not all pollution was distributed equally in a dynamic urban landscape. Using techniques to examine skewed riskscapes and socioeconomic urban geographies provided a foundation for future research on the connections among environmental health hazard sources, socially vulnerable neighborhoods, and health inequity. PMID:21836115

  16. Interleukin 15 Skews Monocyte Differentiation into Dendritic Cells with Features of Langerhans Cells

    PubMed Central

    Mohamadzadeh, Mansour; Berard, Frederic; Essert, Gregory; Chalouni, Cecile; Pulendran, Bali; Davoust, Jean; Bridges, George; Palucka, A. Karolina; Banchereau, Jacques

    2001-01-01

    Langerhans cells (LCs) represent a subset of immature dendritic cells (DCs) specifically localized in the epidermis and other mucosal epithelia. As surrounding keratinocytes can produce interleukin (IL)-15, a cytokine that utilizes IL-2Rγ chain, we analyzed whether IL-15 could skew monocyte differentiation into LCs. Monocytes cultured for 6 d with granulocyte/macrophage colony-stimulating factor (GM-CSF) and IL-15 differentiate into CD1a+HLA-DR+CD14−DCs (IL15-DCs). Agents such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)α, and CD40L induce maturation of IL15-DCs to CD83+, DC-LAMP+ cells. IL15-DCs are potent antigen-presenting cells able to induce the primary (mixed lymphocyte reaction [MLR]) and secondary (recall responses to flu-matrix peptide) immune responses. As opposed to cultures made with GM-CSF/IL-4 (IL4-DCs), a proportion of IL15-DCs expresses LC markers: E-Cadherin, Langerin, and CC chemokine receptor (CCR)6. Accordingly, IL15-DCs, but not IL4-DCs, migrate in response to macrophage inflammatory protein (MIP)-3α/CCL20. However, IL15-DCs cannot be qualified as “genuine” Langerhans cells because, despite the presence of the 43-kD Langerin, they do not express bona fide Birbeck granules. Thus, our results demonstrate a novel pathway in monocyte differentiation into dendritic cells. PMID:11581322

  17. Effect of Slot Combination and Skewed Slot on Electromagnetic Vibration of Capacitor Motor under Load

    NASA Astrophysics Data System (ADS)

    Hirotsuka, Isao; Tsuboi, Kazuo

    The capacitor motor (CRM) is widely used to drive industrial equipments and electric home appliances. Recently, the reduction in the vibration and noise of the CRM has become increasingly important from the standpoint of environmental improvement. However, the electromagnetic vibration of the CRM under load has not been analyzed sufficiently. Therefore, we have studied the electromagnetic vibration of CRM for the purpose of reducing it. In a previous paper, the relationships for a backward magnetic field, the equivalent circuit current, and the vibration of the CRM were clarified. The present paper theoretically and experimentally discusses the effect of the slot combination and skewed slot on the electromagnetic vibration of CRM under load. The primary conclusions are as follows: (1) In the case of 4-pole and 6-pole CRMs, the dominant electromagnetic vibration of CRMs was theoretically attributed to three types of electromagnetic force waves. Two types of electromagnetic force waves are generated: one wave is generated by the interaction of two forward magnetic fluxes, such as those of a three-phase squirrel-cage induction motor, and the other wave is generated under the influence of a backward magnetic flux. (2) The characteristics of dominant electromagnetic vibration depending on load and running capacitor were classified theoretically and experimentally into three types based on the characteristics of the electromagnetic force wave and equivalent circuit current. (3) The influences of magnetic saturation in dominant electromagnetic vibration were verified experimentally and their causes were clarified theoretically in relation to electromagnetic force waves.

  18. Viruses-to-mobile genetic elements skew in the deep Atlantis II brine pool sediments

    PubMed Central

    Adel, Mustafa; Elbehery, Ali H. A.; Aziz, Sherry K.; Aziz, Ramy K.; Grossart, Hans-Peter; Siam, Rania

    2016-01-01

    The central rift of the Red Sea has 25 brine pools with different physical and geochemical characteristics. Atlantis II (ATIID), Discovery Deeps (DD) and Chain Deep (CD) are characterized by high salinity, temperature and metal content. Several studies reported microbial communities in these brine pools, but few studies addressed the brine pool sediments. Therefore, sediment cores were collected from ATIID, DD, CD brine pools and an adjacent brine-influenced site. Sixteen different lithologic sediment sections were subjected to shotgun DNA pyrosequencing to generate 1.47 billion base pairs (1.47 × 109 bp). We generated sediment-specific reads and attempted to annotate all reads. We report the phylogenetic and biochemical uniqueness of the deepest ATIID sulfur-rich brine pool sediments. In contrary to all other sediment sections, bacteria dominate the deepest ATIID sulfur-rich brine pool sediments. This decrease in virus-to-bacteria ratio in selected sections and depth coincided with an overrepresentation of mobile genetic elements. Skewing in the composition of viruses-to-mobile genetic elements may uniquely contribute to the distinct microbial consortium in sediments in proximity to hydrothermally active vents of the Red Sea and possibly in their surroundings, through differential horizontal gene transfer. PMID:27596223

  19. Gluten-containing grains skew gluten assessment in oats due to sample grind non-homogeneity.

    PubMed

    Fritz, Ronald D; Chen, Yumin; Contreras, Veronica

    2017-02-01

    Oats are easily contaminated with gluten-rich kernels of wheat, rye and barley. These contaminants are like gluten 'pills', shown here to skew gluten analysis results. Using R-Biopharm R5 ELISA, we quantified gluten in gluten-free oatmeal servings from an in-market survey. For samples with a 5-20ppm reading on a first test, replicate analyses provided results ranging <5ppm to >160ppm. This suggests sample grinding may inadequately disperse gluten to allow a single accurate gluten assessment. To ascertain this, and characterize the distribution of 0.25-g gluten test results for kernel contaminated oats, twelve 50g samples of pure oats, each spiked with a wheat kernel, showed that 0.25g test results followed log-normal-like distributions. With this, we estimate probabilities of mis-assessment for a 'single measure/sample' relative to the <20ppm regulatory threshold, and derive an equation relating the probability of mis-assessment to sample average gluten content. PMID:27596406

  20. Improved estimates of the range of errors on photomasks using measured values of skewness and kurtosis

    NASA Astrophysics Data System (ADS)

    Hamaker, Henry Chris

    1995-12-01

    Statistical process control (SPC) techniques often use six times the standard deviation sigma to estimate the range of errors within a process. Two assumptions are inherent in this choice of metric for the range: (1) the normal distribution adequately describes the errors, and (2) the fraction of errors falling within plus or minus 3 sigma, about 99.73%, is sufficiently large that we may consider the fraction occurring outside this range to be negligible. In state-of-the-art photomasks, however, the assumption of normality frequently breaks down, and consequently plus or minus 3 sigma is not a good estimate of the range of errors. In this study, we show that improved estimates for the effective maximum error Em, which is defined as the value for which 99.73% of all errors fall within plus or minus Em of the mean mu, may be obtained by quantifying the deviation from normality of the error distributions using the skewness and kurtosis of the error sampling. Data are presented indicating that in laser reticle- writing tools, Em less than or equal to 3 sigma. We also extend this technique for estimating the range of errors to specifications that are usually described by mu plus 3 sigma. The implications for SPC are examined.

  1. Compressive VOF method with skewness correction to capture sharp interfaces on arbitrary meshes

    NASA Astrophysics Data System (ADS)

    Denner, Fabian; van Wachem, Berend G. M.

    2014-12-01

    The accurate and efficient modelling of two-phase flows is at present mostly limited to structured, unskewed meshes, due to the additional topological and numerical complexity of arbitrary, unstructured meshes. Compressive VOF methods which discretize the interface advection with algebraic differencing schemes are computationally efficient and inherently applicable to arbitrary meshes. However, compressive VOF methods evidently suffer severely from numerical diffusion on meshes with topological skewness. In this paper we present a compressive VOF method using a state-of-the-art donor-acceptor advection scheme which includes novel modifications to substantially reduce numerical diffusion on arbitrary meshes without adding computational complexity. The new methodology accurately captures evolving interfaces on any arbitrary, non-overlapping mesh and conserves mass within the limits of the applied solver tolerance. A thorough validation of the presented methods is conducted, examining the pure advection of the interface indicator function as well as the application to evolving interfaces with surface tension. Crucially, the results on equidistant Cartesian and arbitrary tetrahedral meshes are shown to be comparable and accurate.

  2. A Unique Dermal Dendritic Cell Subset That Skews the Immune Response toward Th2

    PubMed Central

    Hashimoto, Shin-ichi; Nagai, Shigenori; Hattori, Masahira; Irimura, Tatsuro

    2013-01-01

    Dendritic cell (DC) subsets in the skin and draining lymph nodes (LNs) are likely to elicit distinct immune response types. In skin and skin-draining LNs, a dermal DC subset expressing macrophage galactose-type C-type lectin 2 (MGL2/CD301b) was found distinct from migratory Langerhans cells (LCs) or CD103+ dermal DCs (dDCs). Lower expression levels of Th1-promoting and/or cross-presentation-related molecules were suggested by the transcriptome analysis and verified by the quantitative real-time PCR analysis in MGL2+ dDCs than in CD103+ dDCs. Transfer of MGL2+ dDCs but not CD103+ dDCs from FITC-sensitized mice induced a Th2-type immune response in vivo in a model of contact hypersensitivity. Targeting MGL2+ dDCs with a rat monoclonal antibody against MGL2 efficiently induced a humoral immune response with Th2-type properties, as determined by the antibody subclass. We propose that the properties of MGL2+ dDCs, are complementary to those of CD103+ dDCs and skew the immune response toward a Th2-type response. PMID:24039898

  3. Development and Validation of a New Blade Element Momentum Skewed-Wake Model within AeroDyn: Preprint

    SciTech Connect

    Ning, S. A.; Hayman, G.; Damiani, R.; Jonkman, J.

    2014-12-01

    Blade element momentum methods, though conceptually simple, are highly useful for analyzing wind turbines aerodynamics and are widely used in many design and analysis applications. A new version of AeroDyn is being developed to take advantage of new robust solution methodologies, conform to a new modularization framework for National Renewable Energy Laboratory's FAST, utilize advanced skewed-wake analysis methods, fix limitations with previous implementations, and to enable modeling of highly flexible and nonstraight blades. This paper reviews blade element momentum theory and several of the options available for analyzing skewed inflow. AeroDyn implementation details are described for the benefit of users and developers. These new options are compared to solutions from the previous version of AeroDyn and to experimental data. Finally, recommendations are given on how one might select from the various available solution approaches.

  4. White-Matter Tract Connecting Anterior Insula to Nucleus Accumbens Correlates with Reduced Preference for Positively Skewed Gambles.

    PubMed

    Leong, Josiah K; Pestilli, Franco; Wu, Charlene C; Samanez-Larkin, Gregory R; Knutson, Brian

    2016-01-01

    Individuals sometimes show inconsistent risk preferences, including excessive attraction to gambles featuring small chances of winning large amounts (called "positively skewed" gambles). While functional neuroimaging research indicates that nucleus accumbens (NAcc) and anterior insula (AIns) activity inversely predict risky choice, structural connections between these regions have not been described in humans. By combining diffusion-weighted MRI with tractography, we identified the anatomical trajectory of white-matter tracts projecting from the AIns to the NAcc and statistically validated these tracts using Linear Fascicle Evaluation (LiFE) and virtual lesions. Coherence of the right AIns-NAcc tract correlated with reduced preferences for positively skewed gambles. Further, diminished NAcc activity during gamble presentation mediated the association between tract structure and choice. These results identify an unreported tract connecting the AIns to the NAcc in humans and support the notion that structural connections can alter behavior by influencing brain activity as individuals weigh uncertain gains against uncertain losses. PMID:26748088

  5. Bayesian inference for a nonlinear mixed-effects Tobit model with multivariate skew-t distributions: application to AIDS studies

    PubMed Central

    Dagne, Getachew; Huang, Yangxin

    2016-01-01

    Censored data are characteristics of many bioassays in HIV/AIDS studies where assays may not be sensitive enough to determine gradations in viral load determination among those below a detectable threshold. Not accounting for such left-censoring appropriately can lead to biased parameter estimates in most data analysis. To properly adjust for left-censoring, this paper presents an extension of the Tobit model for fitting nonlinear dynamic mixed-effects models with skew distributions. Such extensions allow one to specify the conditional distributions for viral load response to account for left-censoring, skewness and heaviness in the tails of the distributions of the response variable. A Bayesian modeling approach via Markov Chain Monte Carlo (MCMC) algorithm is used to estimate model parameters. The proposed methods are illustrated using real data from an HIV/AIDS study. PMID:22992288

  6. Non-skew-symmetric classical r-matrices, algebraic Bethe ansatz, and Bardeen-Cooper-Schrieffer-type integrable systems

    SciTech Connect

    Skrypnyk, T.

    2009-03-15

    We construct quantum integrable systems associated with non-skew-symmetric gl(2)-valued classical r-matrices. We find a new explicit multiparametric family of such the non-skew-symmetric classical r-matrices. We consider two classes of examples of the corresponding integrable systems, namely generalized Gaudin systems with and without an external magnetic field. In the case of arbitrary r-matrices diagonal in a standard gl(2)-basis, we calculate the spectrum of the corresponding quantum integrable systems using the algebraic Bethe ansatz. We apply these results to a construction of integrable fermionic models and obtain a wide class of integrable Bardeen-Cooper-Schrieffer (BCS)-type fermionic Hamiltonians containing the pairing and electrostatic interaction terms. We also consider special cases when the corresponding integrable Hamiltonians contain only pairing interaction term and are exact analogs of the 'reduced BCS Hamiltonian' of Richardson.

  7. Beam-Based Confirmation of Skew-Quadrupole Field Correction in 10.8 m Long Undulator

    SciTech Connect

    Hisaoka, Yoshinori; Hisao, Shintarou; Matsubara, Takahiro; Mitsui, Takayuki; Miyamoto, Shuji; Shoji, Yoshihiko

    2007-01-19

    The synchrotron radiation facility NewSUBARU is a 1.5 GeV storage ring which has two long straight sections. A permanent magnet, planar-type, out-of-vacuum 10.8 m Long Undulator is placed in one of the long straight sections. The longitudinal moments of the skew-quadrupole field errors in the undulator were determined from the response of the stored beam. The method used was to measure the change of the horizontal closed orbit distortion produced by two types of vertical local bump orbit in the undulator. This method is more reliable than the global modeling of a ring, which uses the response matrix of the whole ring, since the present method is not sensitive to skew-quadrupole field errors in sections other than the target section.

  8. Thermodynamics of the Mn12-ac molecule in a skew magnetic field at T \\gtrsim 21 K

    NASA Astrophysics Data System (ADS)

    Rojas, Onofre; Thomaz, M. T.; Corrêa Silva, E. V.; de Souza, S. M.

    2009-01-01

    We derive the high-temperature expansion of the Helmholtz free energy of the quantum and classical models for the Mn12-ac molecule in the presence of a skew magnetic field, including the transverse term in the Hamiltonians, for T \\gtrsim 21 K. In this region of temperature, we show that the transverse term can give a measurable contribution to the x component of the magnetization. We obtain the specific heat per site of a powder sample of Mn12-ac under a constant magnetic field. For strong skew magnetic fields (h/D>1), the specific heat differs up to 20% from its value of a crystal sample under purely longitudinal magnetic fields. Finally, we obtain that in the limit T \\rightarrow \\infty , the values of the classical and quantum specific heat differ; in particular, for \\vec {h}= \\vec 0 this difference is 0.96%.

  9. Bayesian inference for a nonlinear mixed-effects Tobit model with multivariate skew-t distributions: application to AIDS studies.

    PubMed

    Dagne, Getachew; Huang, Yangxin

    2012-01-01

    Censored data are characteristics of many bioassays in HIV/AIDS studies where assays may not be sensitive enough to determine gradations in viral load determination among those below a detectable threshold. Not accounting for such left-censoring appropriately can lead to biased parameter estimates in most data analysis. To properly adjust for left-censoring, this paper presents an extension of the Tobit model for fitting nonlinear dynamic mixed-effects models with skew distributions. Such extensions allow one to specify the conditional distributions for viral load response to account for left-censoring, skewness and heaviness in the tails of the distributions of the response variable. A Bayesian modeling approach via Markov Chain Monte Carlo (MCMC) algorithm is used to estimate model parameters. The proposed methods are illustrated using real data from an HIV/AIDS study. PMID:22992288

  10. Skewed task conflicts in teams: What happens when a few members see more conflict than the rest?

    PubMed

    Sinha, Ruchi; Janardhanan, Niranjan S; Greer, Lindred L; Conlon, Donald E; Edwards, Jeffery R

    2016-07-01

    Task conflict has been the subject of a long-standing debate in the literature-when does task conflict help or hurt team performance? We propose that this debate can be resolved by taking a more precise view of how task conflicts are perceived in teams. Specifically, we propose that in teams, when a few team members perceive a high level of task disagreement while a majority of others perceive low levels of task disagreement-that is, there is positively skewed task conflict, task conflict is most likely to live up to its purported benefits for team performance. In our first study of student teams engaged in a business decision game, we find support for the positive relationship between skewed task conflict and team performance. In our second field study of teams in a financial corporation, we find that the relationship between positively skewed task conflict and supervisor ratings of team performance is mediated by reflective communication within the team. (PsycINFO Database Record PMID:26949822

  11. Reversible chair ↔ skew conformational interconversion of 1,3,2-dioxaphosphorinane ring in the solid state.

    PubMed

    Řlepokura, Katarzyna Anna

    2016-02-01

    β-NH4[(MeO)2cDHAP] (where cDHAP is cyclic dihydroxyacetone phosphate) has been investigated by X-ray crystallography in the temperature range 350-100 K. Three reversible single-crystal-to-single-crystal phase transitions have been examined and four phases (high-, room-, medium- and low-temperature phase, HTP, RTP, MTP and LTP, respectively) have been structurally determined: HTP (at 350 K, P2(1)/a, Z = 24), RTP (290 K, P1, Z = 12), MTP (205 K, P2(1)/a, Z = 4) and LTP (100 K, P1, Z = 24). Various puckering modes of the 1,3,2-dioxaphosphorinane ring of the organic cyclic phosphate anion have been revealed in the crystal: chair and skew. The chair ↔ skew ring flipping, which has been shown to take place during the phase transitions, results in various populations of skew and chair conformers in different phases. The flexibility in the coordination geometry of ammonium cations is considered to assist in the conformational flexibility of the dioxaphosphorinane ring. PMID:26830803

  12. Bayesian semiparametric nonlinear mixed-effects joint models for data with skewness, missing responses, and measurement errors in covariates.

    PubMed

    Huang, Yangxin; Dagne, Getachew

    2012-09-01

    It is a common practice to analyze complex longitudinal data using semiparametric nonlinear mixed-effects (SNLME) models with a normal distribution. Normality assumption of model errors may unrealistically obscure important features of subject variations. To partially explain between- and within-subject variations, covariates are usually introduced in such models, but some covariates may often be measured with substantial errors. Moreover, the responses may be missing and the missingness may be nonignorable. Inferential procedures can be complicated dramatically when data with skewness, missing values, and measurement error are observed. In the literature, there has been considerable interest in accommodating either skewness, incompleteness or covariate measurement error in such models, but there has been relatively little study concerning all three features simultaneously. In this article, our objective is to address the simultaneous impact of skewness, missingness, and covariate measurement error by jointly modeling the response and covariate processes based on a flexible Bayesian SNLME model. The method is illustrated using a real AIDS data set to compare potential models with various scenarios and different distribution specifications. PMID:22150787

  13. Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction.

    PubMed

    Hoentjen, Frank; Hanauer, Stephen B; de Boer, Nanne K; Rubin, David T

    2012-01-01

    Thiopurine therapy effectively maintains remission in inflammatory bowel disease. However, many patients are unable to achieve optimum benefits from azathioprine or 6-mercaptopurine because of undesirable metabolism related to high thiopurine methyltransferase (TPMT) activity characterized by hepatic transaminitis secondary to increased 6-methylmercaptopurine (6-MMP) production and reduced levels of therapeutic 6-thioguanine nucleotide (6-TGN). Allopurinol can optimize this skewed metabolism. We discuss two brothers who were both diagnosed with ulcerative colitis (UC). Their disease remained active despite oral and topical mesalamines. Steroids followed by 6-mercaptopurine (MP) were unsuccessfully introduced for both patients and both were found to have high 6-MMP and low 6-TGN levels, despite normal TMPT enzyme activity, accompanied by transaminitis. Allopurinol was introduced in combination with MP dose reduction. For both brothers addition of allopurinol was associated with successful remission and optimized MP metabolites. These siblings with active UC illustrate that skewed thiopurine metabolism may occur despite normal TPMT enzyme activity and can lead to adverse events in the absence of disease control. We confirm previous data showing that addition of allopurinol can reverse this skewed metabolism, and reduce both hepatotoxicity and disease activity, but we now also introduce the concept of a family history of preferential MP metabolism as a clue to effective management for other family members. PMID:22147254

  14. Effects of pristane alone or combined with chloroquine on macrophage activation, oxidative stress, and TH1/TH2 skewness.

    PubMed

    Ouyang, Qiufang; Huang, Ziyang; Wang, Zhenhua; Chen, Xiaoqing; Ni, Jingqin; Lin, Ling

    2014-01-01

    We investigated the protective role of chloroquine against pristane-induced macrophage activation, oxidative stress, and Th1/Th2 skewness in C57BL/6J mice. Those mice were treated with pristane alone or combined with chloroquine. Hematological and biochemical parameters, macrophage phagocytic function, the oxidant/antioxidant index, cytokine for IFN-γ, TNF-α, IL-4, and IL-6, and the isotypes of IgG2a and IgG1 were determined. And the expression of T-bet/GATA-3 and IL-12/IL-10 mRNA in spleen were analyzed by real-time PCR. We found that pristane treatment for a period of 12 or 24 weeks triggered macrophage activation syndrome, characterized by hemophagocytosis in spleen and peripheral blood, enhanced lipid phagocytosis by peritoneal macrophages in vitro, erythropenia and leucopenia, increased anti-Smith, lactic dehydrogenase, triglyceride, and ferritin, as well as hypercytokinemia of IFN-γ, TNF-α, IL-4, and IL-6. In parallel, a significant increase in lipid peroxidation and a decrease in superoxide dismutase, glutathione, and catalase activity, as well as a skewed Th1/Th2 balance in spleen, were observed. However, chloroquine supplementation showed a remarkable amelioration of these abnormalities. Our data indicate that pristane administration induces macrophage activation, oxidative stress, and Th1/Th2 skewness, which can be attenuated by chloroquine. PMID:25136646

  15. Androgen receptor blockade using flutamide skewed sex ratio of litters in mice.

    PubMed

    Gharagozlou, Faramarz; Youssefi, Reza; Vojgani, Mehdi; Akbarinejad, Vahid; Rafiee, Ghazaleh

    2016-01-01

    Maternal testosterone has been indicated to affect sex ratio of offspring. The present study was conducted to elucidate the role of androgen receptor in this regard by blockade of androgen receptor using flutamide in female mice. Mice were randomly assigned to two experimental groups. Mice in the control (n = 20) and treatment (n = 20) groups received 8 IU equine chorionic gonadotropin (eCG) followed by human chorionic gonadotropin (hCG) injection (8 IU) 47 hr later. In addition, mice in the control and treatment groups received four injections of ethanol-saline vehicle and flutamide solution (2.50 mg), respectively, started from 1 hr before eCG injection until hCG injection at 12-hr intervals. Conception rate was not different between the treatment (18/20: 90.00%) and control (19/20: 95.00%) groups (p > 0.05). Litter size was higher in the treatment (8.22 ± 0.26) than control (7.21 ± 0.28) group (p < 0.05). Male sex ratio was lower in the flutamide-treated mice (67/148: 45.30%) as compared with the untreated ones (80/137: 58.40%; odds ratio = 1.69; p < 0.05). In conclusion, the results showed that androgen receptor blockade could skew sex ratio of offspring toward females implying that the effect of testosterone on sex ratio might be through binding to androgen receptor. In addition, the blockade of androgen receptor using flutamide appeared to enhance litter size. PMID:27482363

  16. Androgen receptor blockade using flutamide skewed sex ratio of litters in mice

    PubMed Central

    Gharagozlou, Faramarz; Youssefi, Reza; Vojgani, Mehdi; Akbarinejad, Vahid; Rafiee, Ghazaleh

    2016-01-01

    Maternal testosterone has been indicated to affect sex ratio of offspring. The present study was conducted to elucidate the role of androgen receptor in this regard by blockade of androgen receptor using flutamide in female mice. Mice were randomly assigned to two experimental groups. Mice in the control (n = 20) and treatment (n = 20) groups received 8 IU equine chorionic gonadotropin (eCG) followed by human chorionic gonadotropin (hCG) injection (8 IU) 47 hr later. In addition, mice in the control and treatment groups received four injections of ethanol-saline vehicle and flutamide solution (2.50 mg), respectively, started from 1 hr before eCG injection until hCG injection at 12-hr intervals. Conception rate was not different between the treatment (18/20: 90.00%) and control (19/20: 95.00%) groups (p > 0.05). Litter size was higher in the treatment (8.22 ± 0.26) than control (7.21 ± 0.28) group (p < 0.05). Male sex ratio was lower in the flutamide-treated mice (67/148: 45.30%) as compared with the untreated ones (80/137: 58.40%; odds ratio = 1.69; p < 0.05). In conclusion, the results showed that androgen receptor blockade could skew sex ratio of offspring toward females implying that the effect of testosterone on sex ratio might be through binding to androgen receptor. In addition, the blockade of androgen receptor using flutamide appeared to enhance litter size. PMID:27482363

  17. Performance-based seismic assessment of skewed bridges with and without considering soil-structure interaction effects for various site classes

    NASA Astrophysics Data System (ADS)

    Ghotbi, Abdoulreza

    This study aims to investigate the behavior of skewed and straight highway overpass bridges both with and without taking into account the effects of Soil-Structure Interaction (SSI) due to near-fault ground motions. Both deterministic (i.e., pushover and nonlinear dynamic analyses) and probabilistic approaches were utilized. A set of response sensitivity analyses was performed considering various skew angles, column elements, and soil properties for bridge considered both as fixed-base and SSI models. It has been observed that as the skew angle increased, the bridge responded more severely to the ground motion. For instance, the deck rotation and shear-keys displacement increased with an increase in the skew angle. A modal pushover analysis was also performed in conjunction with the nonlinear dynamic analysis. It has been found that combining the bridge responses for various modes of vibration resulted in a relatively accurate seismic response compared to the nonlinear dynamic analysis while saving time and analysis cost, to a great extent. A probabilistic analysis was also performed considering record-to-record variability in ground motion, and a set of probabilistic seismic demand and fragility plots was generated. The effects of change in the skew angle and also SSI were studied to see various bridge responses. The damage probability increased especially with respect to deck rotation as the skew angle increased. The SSI had a decreasing effect on the overall response of the bridge with pile foundation.

  18. Influence of skew rays on the sensitivity and signal-to-noise ratio of a fiber-optic surface-plasmon-resonance sensor: a theoretical study

    SciTech Connect

    Dwivedi, Yogendra S.; Sharma, Anuj K.; Gupta, Banshi D

    2007-07-20

    We have theoretically analyzed the influence of skew rays on the performance of a fiber-optic sensor based on surface plasmon resonance. The performance of the sensor has been evaluated in terms of its sensitivity and signal-to-noise ratio (SNR). The theoretical model for skewness dependence includes the material dispersion in fiber cores and metal layers, simultaneous excitation of skew rays, and meridional rays in the fiber core along with all guided rays launching from a collimated light source. The effect of skew rays on the SNR and the sensitivity of the sensor with two different metals has been compared. The same comparison is carried out for the different values of design parameters such as numerical aperture, fiber core diameter, and the length of the surface-plasmon-resonance (SPR)active sensing region. This detailed analysis for the effect of skewness on the SNR and the sensitivity of the sensor leads us to achieve the best possible performance from a fiber-optic SPR sensor against the skewness in the optical fiber.

  19. Jointly Modeling Event Time and Skewed-Longitudinal Data with Missing Response and Mismeasured Covariate for AIDS Studies.

    PubMed

    Huang, Yangxin; Yan, Chunning; Xing, Dongyuan; Zhang, Nanhua; Chen, Henian

    2015-01-01

    In longitudinal studies it is often of interest to investigate how a repeatedly measured marker in time is associated with a time to an event of interest. This type of research question has given rise to a rapidly developing field of biostatistics research that deals with the joint modeling of longitudinal and time-to-event data. Normality of model errors in longitudinal model is a routine assumption, but it may be unrealistically obscuring important features of subject variations. Covariates are usually introduced in the models to partially explain between- and within-subject variations, but some covariates such as CD4 cell count may be often measured with substantial errors. Moreover, the responses may encounter nonignorable missing. Statistical analysis may be complicated dramatically based on longitudinal-survival joint models where longitudinal data with skewness, missing values, and measurement errors are observed. In this article, we relax the distributional assumptions for the longitudinal models using skewed (parametric) distribution and unspecified (nonparametric) distribution placed by a Dirichlet process prior, and address the simultaneous influence of skewness, missingness, covariate measurement error, and time-to-event process by jointly modeling three components (response process with missing values, covariate process with measurement errors, and time-to-event process) linked through the random-effects that characterize the underlying individual-specific longitudinal processes in Bayesian analysis. The method is illustrated with an AIDS study by jointly modeling HIV/CD4 dynamics and time to viral rebound in comparison with potential models with various scenarios and different distributional specifications. PMID:24905593

  20. Regional skew for California, and flood frequency for selected sites in the Sacramento-San Joaquin River Basin, based on data through water year 2006

    USGS Publications Warehouse

    Parrett, Charles; Veilleux, Andrea; Stedinger, J.R.; Barth, N.A.; Knifong, Donna L.; Ferris, J.C.

    2011-01-01

    Improved flood-frequency information is important throughout California in general and in the Sacramento-San Joaquin River Basin in particular, because of an extensive network of flood-control levees and the risk of catastrophic flooding. A key first step in updating flood-frequency information is determining regional skew. A Bayesian generalized least squares (GLS) regression method was used to derive a regional-skew model based on annual peak-discharge data for 158 long-term (30 or more years of record) stations throughout most of California. The desert areas in southeastern California had too few long-term stations to reliably determine regional skew for that hydrologically distinct region; therefore, the desert areas were excluded from the regional skew analysis for California. Of the 158 long-term stations used to determine regional skew, 145 have minimally regulated annual-peak discharges, and 13 stations are dam sites for which unregulated peak discharges were estimated from unregulated daily maximum discharge data furnished by the U.S. Army Corp of Engineers. Station skew was determined by using an expected moments algorithm (EMA) program for fitting the Pearson Type 3 flood-frequency distribution to the logarithms of annual peak-discharge data. The Bayesian GLS regression method previously developed was modified because of the large cross correlations among concurrent recorded peak discharges in California and the use of censored data and historical flood information with the new expected moments algorithm. In particular, to properly account for these cross-correlation problems and develop a suitable regression model and regression diagnostics, a combination of Bayesian weighted least squares and generalized least squares regression was adopted. This new methodology identified a nonlinear function relating regional skew to mean basin elevation. The regional skew values ranged from -0.62 for a mean basin elevation of zero to 0.61 for a mean basin elevation

  1. Grid generation in three dimensions by Poisson equations with control of cell size and skewness at boundary surfaces

    NASA Technical Reports Server (NTRS)

    Sorenson, R. L.; Steger, J. L.

    1983-01-01

    An algorithm for generating computational grids about arbitrary three-dimensional bodies is developed. The elliptic partial differential equation (PDE) approach developed by Steger and Sorenson and used in the NASA computer program GRAPE is extended from two to three dimensions. Forcing functions which are found automatically by the algorithm give the user the ability to control mesh cell size and skewness at boundary surfaces. This algorithm, as is typical of PDE grid generators, gives smooth grid lines and spacing in the interior of the grid. The method is applied to a rectilinear wind-tunnel case and to two body shapes in spherical coordinates.

  2. Performance-based seismic assessment of skewed bridges with and without considering soil-foundation interaction effects for various site classes

    NASA Astrophysics Data System (ADS)

    Ghotbi, Abdoul R.

    2014-09-01

    The seismic behavior of skewed bridges has not been well studied compared to straight bridges. Skewed bridges have shown extensive damage, especially due to deck rotation, shear keys failure, abutment unseating and column-bent drift. This research, therefore, aims to study the behavior of skewed and straight highway overpass bridges both with and without taking into account the effects of Soil-Structure Interaction (SSI) due to near-fault ground motions. Due to several sources of uncertainty associated with the ground motions, soil and structure, a probabilistic approach is needed. Thus, a probabilistic methodology similar to the one developed by the Pacific Earthquake Engineering Research Center (PEER) has been utilized to assess the probability of damage due to various levels of shaking using appropriate intensity measures with minimum dispersions. The probabilistic analyses were performed for various bridge configurations and site conditions, including sand ranging from loose to dense and clay ranging from soft to stiff, in order to evaluate the effects. The results proved a considerable susceptibility of skewed bridges to deck rotation and shear keys displacement. It was also found that SSI had a decreasing effect on the damage probability for various demands compared to the fixed-base model without including SSI. However, deck rotation for all types of the soil and also abutment unseating for very loose sand and soft clay showed an increase in damage probability compared to the fixed-base model. The damage probability for various demands has also been found to decrease with an increase of soil strength for both sandy and clayey sites. With respect to the variations in the skew angle, an increase in skew angle has had an increasing effect on the amplitude of the seismic response for various demands. Deck rotation has been very sensitive to the increase in the skew angle; therefore, as the skew angle increased, the deck rotation responded accordingly

  3. Development of regional skews for selected flood durations for the Central Valley Region, California, based on data through water year 2008

    USGS Publications Warehouse

    Lamontagne, Jonathan R.; Stedinger, Jery R.; Berenbrock, Charles; Veilleux, Andrea G.; Ferris, Justin C.; Knifong, Donna L.

    2012-01-01

    Flood-frequency information is important in the Central Valley region of California because of the high risk of catastrophic flooding. Most traditional flood-frequency studies focus on peak flows, but for the assessment of the adequacy of reservoirs, levees, other flood control structures, sustained flood flow (flood duration) frequency data are needed. This study focuses on rainfall or rain-on-snow floods, rather than the annual maximum, because rain events produce the largest floods in the region. A key to estimating flood-duration frequency is determining the regional skew for such data. Of the 50 sites used in this study to determine regional skew, 28 sites were considered to have little to no significant regulated flows, and for the 22 sites considered significantly regulated, unregulated daily flow data were synthesized by using reservoir storage changes and diversion records. The unregulated, annual maximum rainfall flood flows for selected durations (1-day, 3-day, 7-day, 15-day, and 30-day) for all 50 sites were furnished by the U.S. Army Corps of Engineers. Station skew was determined by using the expected moments algorithm program for fitting the Pearson Type 3 flood-frequency distribution to the logarithms of annual flood-duration data. Bayesian generalized least squares regression procedures used in earlier studies were modified to address problems caused by large cross correlations among concurrent rainfall floods in California and to address the extensive censoring of low outliers at some sites, by using the new expected moments algorithm for fitting the LP3 distribution to rainfall flood-duration data. To properly account for these problems and to develop suitable regional-skew regression models and regression diagnostics, a combination of ordinary least squares, weighted least squares, and Bayesian generalized least squares regressions were adopted. This new methodology determined that a nonlinear model relating regional skew to mean basin elevation

  4. A Bayesian mixture of semiparametric mixed-effects joint models for skewed-longitudinal and time-to-event data.

    PubMed

    Chen, Jiaqing; Huang, Yangxin

    2015-09-10

    In longitudinal studies, it is of interest to investigate how repeatedly measured markers in time are associated with a time to an event of interest, and in the mean time, the repeated measurements are often observed with the features of a heterogeneous population, non-normality, and covariate measured with error because of longitudinal nature. Statistical analysis may complicate dramatically when one analyzes longitudinal-survival data with these features together. Recently, a mixture of skewed distributions has received increasing attention in the treatment of heterogeneous data involving asymmetric behaviors across subclasses, but there are relatively few studies accommodating heterogeneity, non-normality, and measurement error in covariate simultaneously arose in longitudinal-survival data setting. Under the umbrella of Bayesian inference, this article explores a finite mixture of semiparametric mixed-effects joint models with skewed distributions for longitudinal measures with an attempt to mediate homogeneous characteristics, adjust departures from normality, and tailor accuracy from measurement error in covariate as well as overcome shortages of confidence in specifying a time-to-event model. The Bayesian mixture of joint modeling offers an appropriate avenue to estimate not only all parameters of mixture joint models but also probabilities of class membership. Simulation studies are conducted to assess the performance of the proposed method, and a real example is analyzed to demonstrate the methodology. The results are reported by comparing potential models with various scenarios. PMID:25924891

  5. Policy makers will need a way to update bundled payments that reflects highly skewed spending growth of various care episodes.

    PubMed

    Rosen, Allison B; Aizcorbe, Ana; Ryu, Alexander J; Nestoriak, Nicole; Cutler, David M; Chernew, Michael E

    2013-05-01

    Bundled payment entails paying a single price for all services delivered as part of an episode of care for a specific condition. It is seen as a promising way to slow the growth of health care spending while maintaining or improving the quality of care. To implement bundled payment, policy makers must set base payment rates for episodes of care and update the rates over time to reflect changes in the costs of delivering care and the components of care. Adopting the fee-for-service paradigm of adjusting payments with uniform update rates would be fair and accurate if costs increased at a uniform rate across episodes. But our analysis of 2003 and 2007 US commercial claims data showed spending growth to be highly skewed across episodes: 10 percent of episodes accounted for 82.5 percent of spending growth, and within-episode spending growth ranged from a decline of 75 percent to an increase of 323 percent. Given that spending growth was much faster for some episodes than for others, a situation known as skewness, policy makers should not update episode payments using uniform update rates. Rather, they should explore ways to address variations in spending growth, such as updating episode payments one by one, at least at the outset. PMID:23650329

  6. A Skew-t space-varying regression model for the spectral analysis of resting state brain activity.

    PubMed

    Ismail, Salimah; Sun, Wenqi; Nathoo, Farouk S; Babul, Arif; Moiseev, Alexader; Beg, Mirza Faisal; Virji-Babul, Naznin

    2013-08-01

    It is known that in many neurological disorders such as Down syndrome, main brain rhythms shift their frequencies slightly, and characterizing the spatial distribution of these shifts is of interest. This article reports on the development of a Skew-t mixed model for the spatial analysis of resting state brain activity in healthy controls and individuals with Down syndrome. Time series of oscillatory brain activity are recorded using magnetoencephalography, and spectral summaries are examined at multiple sensor locations across the scalp. We focus on the mean frequency of the power spectral density, and use space-varying regression to examine associations with age, gender and Down syndrome across several scalp regions. Spatial smoothing priors are incorporated based on a multivariate Markov random field, and the markedly non-Gaussian nature of the spectral response variable is accommodated by the use of a Skew-t distribution. A range of models representing different assumptions on the association structure and response distribution are examined, and we conduct model selection using the deviance information criterion. (1) Our analysis suggests region-specific differences between healthy controls and individuals with Down syndrome, particularly in the left and right temporal regions, and produces smoothed maps indicating the scalp topography of the estimated differences. PMID:22614763

  7. High rates of pregnancy loss by subordinates leads to high reproductive skew in wild golden lion tamarins (Leontopithecus rosalia)

    PubMed Central

    Henry, MaLinda D.; Hankerson, Sarah J.; Siani, Jennifer M.; French, Jeffrey A.; Dietz, James M.

    2013-01-01

    Across taxa, cooperative breeding has been associated with high reproductive skew. Cooperatively breeding golden lion tamarins (Leontopithecus rosalia) were long thought to have a monogynous mating system in which reproduction was limited to a single dominant female. Subordinates with few reproductive opportunities delayed dispersal and remained in the natal group to provide alloparental care to siblings, thus allowing dominant reproductive females to meet the energetic needs associated with high rates of reproduction and successful infant rearing. The goal of this study was to re-assess monogyny in wild golden lion tamarin groups based upon pregnancy diagnoses that used non-invasive enzyme immunoassay for progesterone and cortisol, combined with weekly data on individual weight gain, bi-annual physical examinations noting pregnancy and lactation status and daily behavioral observations. We established quantitative and qualitative criteria to detect and determine the timing of pregnancies that did not result in the birth of infants. Pregnancy polygyny occurred in 83% of golden lion tamarin groups studied. The loss of 64% of subordinate pregnancies compared to only 15% by dominant females limited reproductive success mainly to dominant females, thus maintaining high reproductive skew in female golden lion tamarins. Pregnancy loss by subordinate adults did not appear to result from dominant interference in subordinate hormonal mechanisms, but more likely resulted from subordinate abandonment of newborn infants to mitigate dominant aggression. PMID:23454002

  8. A decomposition theorem for the space of C{sup 1}-smooth skew products with complicated dynamics of the quotient map

    SciTech Connect

    Efremova, L S

    2013-11-30

    We use the notions of the Ω-function and functions suitable to it, to give a detailed proof of a decomposition theorem for the space of C{sup 1}-smooth skew products of interval maps whose quotient maps have complicated dynamics and satisfy the additional condition of Ω-stability with respect to the C{sup 1}-norm. In our theorem, the space of C{sup 1}-smooth skew products is decomposed into a union of four nonempty, pairwise disjoint subspaces. We give examples of maps contained in each of the four subspaces. Bibliography: 46 titles.

  9. Approximation of skewed interfaces with tensor-based model reduction procedures: Application to the reduced basis hierarchical model reduction approach

    NASA Astrophysics Data System (ADS)

    Ohlberger, Mario; Smetana, Kathrin

    2016-09-01

    In this article we introduce a procedure, which allows to recover the potentially very good approximation properties of tensor-based model reduction procedures for the solution of partial differential equations in the presence of interfaces or strong gradients in the solution which are skewed with respect to the coordinate axes. The two key ideas are the location of the interface either by solving a lower-dimensional partial differential equation or by using data functions and the subsequent removal of the interface of the solution by choosing the determined interface as the lifting function of the Dirichlet boundary conditions. We demonstrate in numerical experiments for linear elliptic equations and the reduced basis-hierarchical model reduction approach that the proposed procedure locates the interface well and yields a significantly improved convergence behavior even in the case when we only consider an approximation of the interface.

  10. White-Matter Tract Connecting Anterior Insula to Nucleus Accumbens Correlates with Reduced Preference for Positively Skewed Gambles

    PubMed Central

    Leong, Josiah K.; Pestilli, Franco; Wu, Charlene C.; Samanez-Larkin, Gregory R.; Knutson, Brian

    2016-01-01

    SUMMARY Individuals sometimes show inconsistent risk preferences, including excessive attraction to gambles featuring small chances of winning large amounts (called “positively skewed” gambles). While functional neuroimaging research indicates that nucleus accumbens (NAcc) and anterior insula (AIns) activity inversely predict risky choice, structural connections between these regions have not been described in humans. By combining diffusion-weighted MRI with tractography, we identified the anatomical trajectory of white-matter tracts projecting from the AIns to the NAcc and statistically validated these tracts using Linear Fascicle Evaluation (LiFE) and virtual lesions. Coherence of the right AIns-NAcc tract correlated with reduced preferences for positively skewed gambles. Further, diminished NAcc activity during gamble presentation mediated the association between tract structure and choice. These results identify an unreported tract connecting the AIns to the NAcc in humans and support the notion that structural connections can alter behavior by influencing brain activity as individuals weigh uncertain gains against uncertain losses. PMID:26748088

  11. Influence of complex disorder on skew-scattering Hall effects in L 10 -ordered FePt alloy

    NASA Astrophysics Data System (ADS)

    Zimmermann, Bernd; Long, Nguyen H.; Mavropoulos, Phivos; Blügel, Stefan; Mokrousov, Yuriy

    2016-08-01

    We show by first-principles calculations that the skew-scattering anomalous Hall and spin Hall angles of L 10 -ordered FePt drastically depend on different types of disorder. A different sign of the anomalous Hall angle is obtained when slightly deviating from the stoichiometric ratio towards the Fe-rich side as compared to the Pt-rich side. For stoichiometric samples, short-range ordering of defects has a profound effect on the Hall angles and can change them by a factor of 2 as compared to the case of uncorrelated disorder. This might explain the vast range of anomalous Hall angles measured in experiments, which undergo different preparation procedures and thus might differ in their crystallographic quality.

  12. Study of Row Phase Dependent Skew Quadrupole Fields in Apple-II Type EPUs at the ALS

    SciTech Connect

    Steier, C.; Marks, S.; Prestemon, Soren; Robin, David; Schlueter, Ross; Wolski, Andrzej

    2004-05-07

    Since about 5 years, Apple-II type Elliptically Polarizing Undulators (EPU) have been used very successfully at the ALS to generate high brightness photon beams with arbitrary polarization. However, both EPUs installed so far cause significant changes of the vertical beamsize, especially when the row phase is changed to change the polarization of the photons emitted. Detailed measurements indicate this is caused by a row phase dependent skew quadrupole term in the EPUs. Magnetic measurements revealed the same effect for the third EPU to be installed later this year. All measurements to identify and quantify the effect with beam will be presented, as well as some results of magnetic bench measurements and numeric field simulations.

  13. Free fatty acid G-protein coupled receptor signaling in M1 skewed white adipose tissue macrophages.

    PubMed

    Vieira, Warren Antonio; Sadie-Van Gijsen, Hanél; Ferris, William Frank

    2016-10-01

    Obesity is associated with the establishment and maintenance of a low grade, chronically inflamed state in the white adipose tissue (WAT) of the body. The WAT macrophage population is a major cellular participant in this inflammatory process that significantly contributes to the pathophysiology of the disease, with the adipose depots of obese individuals, relative to lean counterparts, having an elevated number of macrophages that are skewed towards a pro-inflammatory phenotype. Alterations in the WAT lipid micro-environment, and specifically the availability of free fatty acids, are believed to contribute towards the obesity-related quantitative and functional changes observed in these cells. This review specifically addresses the involvement of the five G-protein coupled free fatty acid receptors which bind exogenous FFAs and signal in macrophages. Particular focus is placed on the involvement of these receptors in macrophage migration and cytokine production, two important aspects that modulate inflammation. PMID:27173059

  14. Wigner-Yanase skew information and quantum phase transition in one-dimensional quantum spin-1/2 chains

    NASA Astrophysics Data System (ADS)

    Lei, Shuguo; Tong, Peiqing

    2016-04-01

    The quantum coherence based on Wigner-Yanase skew information and its relations with quantum phase transitions (QPTs) in one-dimensional quantum spin-1/2 chains are studied. Different from those at the critical point (CP) of the Ising transition in the transverse-field XY chain, the single-spin quantum coherence and the two-spin local σ ^z quantum coherence are extremal at the CP of the anisotropy transition, and the first-order derivatives of the two-spin local σ ^x and σ ^y quantum coherence have logarithmic divergence with the chain size. For the QPT between the gapped and gapless phases in the chain with three-spin interactions, however, no finite-size scaling behavior of the derivatives of quantum coherence is found.

  15. Noise-Induced Synchronization among Sub-RF CMOS Analog Oscillators for Skew-Free Clock Distribution

    NASA Astrophysics Data System (ADS)

    Utagawa, Akira; Asai, Tetsuya; Hirose, Tetsuya; Amemiya, Yoshihito

    We present on-chip oscillator arrays synchronized by random noises, aiming at skew-free clock distribution on synchronous digital systems. Nakao et al. recently reported that independent neural oscillators can be synchronized by applying temporal random impulses to the oscillators [1], [2]. We regard neural oscillators as independent clock sources on LSIs; i. e., clock sources are distributed on LSIs, and they are forced to synchronize through the use of random noises. We designed neuron-based clock generators operating at sub-RF region (<1GHz) by modifying the original neuron model to a new model that is suitable for CMOS implementation with 0.25-μm CMOS parameters. Through circuit simulations, we demonstrate that i) the clock generators are certainly synchronized by pseudo-random noises and ii) clock generators exhibited phase-locked oscillations even if they had small device mismatches.

  16. Study on Reduction in Vibrations of Concentrated Winding Permanent Magnet Synchronous Motor by Skew Effects of Rotor

    NASA Astrophysics Data System (ADS)

    Takahata, Ryoichi; Wakui, Shinichi; Miyata, Kenji; Noma, Keiji; Senoo, Masaharu

    Recently, global warming and the problem with successfully incorporating environmental safeguards have promoted the need for a more power-efficient motor. Therefore, as a driving source, permanent magnet synchronous motor (PMSM) with concentrated winding is widely used as the important device for a variety of fields. However, a PMSM with concentrated winding generates more vibrations than that with distributed winding because of a radial electromagnetic force. This paper describes the influence of a new skewed rotor on the characteristics of a concentrated winding PMSM. We investigated the influence by using a three-dimensional finite element analysis (3-D FEM) and several measurements. In addition, we presented that the proposed rotor is effective in reducing the radial electromagnetic force without decreasing the motor efficiency.

  17. Haemophilia A and cardiovascular morbidity in a female SHAM syndrome carrier due to skewed X chromosome inactivation.

    PubMed

    Janczar, Szymon; Kosinska, Joanna; Ploski, Rafal; Pastorczak, Agata; Wegner, Olga; Zalewska-Szewczyk, Beata; Paige, Adam J W; Borowiec, Maciej; Mlynarski, Wojciech

    2016-01-01

    We have recently described a severe haemophilia A and moyamoya (SHAM) syndrome caused by Xq28 deletions encompassing F8 and the BRCC3 familial moyamoya gene. The phenotype includes haemophilia A, moyamoya angiopathy, dysmorphia and hypertension. The genetic analysis of the family of our SHAM patient demonstrated carrier state in proband's mother and sister. The patient's mother is apparently well, whereas his currently 18-years-old sister presents with mild haemophilia A, coarctation of the aorta, hypertension, and ventricular arrhythmia. We performed X chromosome inactivation assay based on HpaII methylation analysis of a polymorphic short tandem repeat (STR) in the X linked AR (androgen receptor) gene and used quantitative real-time RT PCR to measure the expression of genes from the deleted region in proband's family members. We found an extremely skewed X chromosome inactivation pattern in the female members of the family leading to preferential inactivation of the X chromosome without Xq28 deletion in patient's sister. We demonstrated differential expression of the genes from the deleted region in four members of the family, that tightly correlates with the clinical features. In conclusion, we show that the haematologic and cardiovascular morbidity and the discrepancy between patient's sister and mother despite the same genetic lesion are due to skewed X chromosome inactivation leading to clinically relevant differential expression of SHAM syndrome genes. This report highlights the role for BRCC3 in cardiovascular physiology and disease, and demonstrates that in some complex hereditary syndromes full diagnostics may require the examination of both genetic and epigenetic events. PMID:26691666

  18. The actin cytoskeleton is a suppressor of the endogenous skewing behaviour of Arabidopsis primary roots in microgravity.

    PubMed

    Nakashima, J; Liao, F; Sparks, J A; Tang, Y; Blancaflor, E B

    2014-01-01

    Before plants can be effectively utilised as a component of enclosed life-support systems for space exploration, it is important to understand the molecular mechanisms by which they develop in microgravity. Using the Biological Research in Canisters (BRIC) hardware on board the second to the last flight of the Space Shuttle Discovery (STS-131 mission), we studied how microgravity impacts root growth in Arabidopsis thaliana. Ground-based studies showed that the actin cytoskeleton negatively regulates root gravity responses on Earth, leading us to hypothesise that actin might also be an important modulator of root growth behaviour in space. We investigated how microgravity impacted root growth of wild type (ecotype Columbia) and a mutant (act2-3) disrupted in a root-expressed vegetative actin isoform (ACTIN2). Roots of etiolated wild-type and act2-3 seedlings grown in space skewed vigorously toward the left, which was unexpected given the reduced directional cue provided by gravity. The left-handed directional root growth in space was more pronounced in act2-3 mutants than wild type. To quantify differences in root orientation of these two genotypes in space, we developed an algorithm where single root images were converted into binary images using computational edge detection methods. Binary images were processed with Fast Fourier Transformation (FFT), and histogram and entropy were used to determine spectral distribution, such that high entropy values corresponded to roots that deviated more strongly from linear orientation whereas low entropy values represented straight roots. We found that act2-3 roots had a statistically stronger skewing/coiling response than wild-type roots, but such differences were not apparent on Earth. Ultrastructural studies revealed that newly developed cell walls of space-grown act2-3 roots were more severely disrupted compared to space-grown wild type, and ground control wild-type and act2-3 roots. Collectively, our results provide

  19. Intraocular lens prediction and oculometric harmony. With special reference to skew ratios between axial length and corneal curvature radius.

    PubMed

    Fich, M; Fledelius, H C

    1993-06-01

    The oculometric features have been analysed in two groups of cataract patients, each comprising 30 subjects. All had undergone ECCE and insertion of biconvex Rayner 2 Superflex posterior chamber IOL. Using Binkhorst and SRK II routinely, the groups were given by a good fit between methods (discrepancy between emmetropia predictions numerically < 1 D) and a poor fit (actual discrepancy range 1.6-4.1 D, all with the same sign, the lower values being predicted by Binkhorst). A certain overlapping between groups was found regarding axial length and corneal curvature radius, the ranges being 21.5-25.1/22.7-29.9 mm and 7.3-8.5/7.2-8.1 mm, respectively. In contrast there was no overlapping regarding the ratio between axial length and corneal curvature radius; the ranges were 2.80-3.05 and 3.06-3.90 in the two groups. Evaluating the actual prediction errors by the two methods (follow-up after at least 4 months), they did not primarily pertain to very short or very long eyes, as usually advanced. Skew ratios between axial length and corneal curvature appeared more decisive. Possible implications for the current IOL prediction formulas, including the newer generations, are discussed. PMID:8362645

  20. On the effect of intermittency of turbulence on the parabolic relation between skewness and kurtosis in magnetized plasmas

    SciTech Connect

    Guszejnov, Dávid; Lazányi, Nóra; Bencze, Attila; Zoletnik, Sándor

    2013-11-15

    This paper is aimed to contribute to the scientific discussions that have been triggered by the experimental observation of a quadratic relation between the kurtosis and skewness of turbulent fluctuations present in fusion plasmas and other nonlinear physical systems. In this paper, we offer a general statistical model which attributes the observed K=aS{sup 2}+b relation to the varying intermittency of the experimental signals. The model is a two random variable model constructed to catch the essential intermittent feature of the real signal. One of the variables is the amplitude of the underlying intermittent event (e.g., turbulent structure) while the other is connected to the intermittency level of the system. This simple model can attribute physical meaning to the a and b coefficients, as they characterize the spatio-temporal statistics of intermittent events. By constructing a particle-conserving Gaussian model for the underlying coherent structures, the experimentally measured a and b coefficients could be adequately reproduced.

  1. Discovery of the Red-Skewed K-alpha Iron Line in Cyg X-2 with Suzaku

    NASA Technical Reports Server (NTRS)

    Shaposhnikov, Nikolai; Titarchuk, Lev; Laurent, Philippe

    2008-01-01

    We report on the Suzaku observation of neutron star low-mass X-ray binary Cygnus X-2 which reveals strong iron K-alpha emission line. The line profile shows a prominent red wing extending down to 4 keV. This discovery increases the number of neutron star sources where red-skewed iron lines were observed and strongly suggests that this phenomenon is common not only in black holes but also in other types of compact objects. We examine the line profile by fitting it with the model which attributes its production to the relativistic effects due to disk reflection of X-ray radiation. We also apply an alternative model where the red wing is a result of down-scattering effect of the first order with respect to electron velocity in the wind outflow. Both models describe adequately the observed line profile. However, the X-ray variability in a state similar to that in the Suzaku observation which we establish by analysing RXTE observation favors the wind origin of the line formation.

  2. Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers

    PubMed Central

    Tinti, Michele; Dissanayake, Kumara; Synowsky, Silvia; Albergante, Luca; MacKintosh, Carol

    2014-01-01

    The complexity of signalling pathways was boosted at the origin of the vertebrates, when two rounds of whole genome duplication (2R-WGD) occurred. Those genes and proteins that have survived from the 2R-WGD—termed 2R-ohnologues—belong to families of two to four members, and are enriched in signalling components relevant to cancer. Here, we find that while only approximately 30% of human transcript-coding genes are 2R-ohnologues, they carry 42–60% of the gene mutations in 30 different cancer types. Across a subset of cancer datasets, including melanoma, breast, lung adenocarcinoma, liver and medulloblastoma, we identified 673 2R-ohnologue families in which one gene carries mutations at multiple positions, while sister genes in the same family are relatively mutation free. Strikingly, in 315 of the 322 2R-ohnologue families displaying such a skew in multiple cancers, the same gene carries the heaviest mutation load in each cancer, and usually the second-ranked gene is also the same in each cancer. Our findings inspire the hypothesis that in certain cancers, heterogeneous combinations of genetic changes impair parts of the 2R-WGD signalling networks and force information flow through a limited set of oncogenic pathways in which specific non-mutated 2R-ohnologues serve as effectors. The non-mutated 2R-ohnologues are therefore potential therapeutic targets. These include proteins linked to growth factor signalling, neurotransmission and ion channels. PMID:24806839

  3. Skewed allele frequencies of an Mx gene mutation with potential resistance to avian influenza virus in different chicken populations.

    PubMed

    Li, X Y; Qu, L J; Yao, J F; Yang, N

    2006-07-01

    The Mx gene is considered to confer positive antiviral responses to the orthomyxovirus in many organisms. In the chicken, 1 nonsynonymous single nucleotide polymorphism (G to A) at position 2,032 of Mx cDNA was demonstrated to confer positive antiviral activity in vitro to avian influenza virus in a previous study. In the current study, 15 Chinese native chicken breeds, 4 highly selected commercial lines, and the Red Jungle Fowl were selected to detect allele frequencies of the Mx mutation. The frequencies of the favorable allele A in native breeds were 0.7241 to 0.9554, which were much higher than those (0.0565 to 0.2742) found in the commercial populations. Whereas most native breeds were in Hardy-Weinberg equilibrium at this locus (P > 0.01), 3 out of 4 commercial populations were not in Hardy-Weinberg equilibrium (P < 0.01). Selection, environment, and negative correlations between production and disease resistant traits could contribute to highly skewed frequencies of the mutation among native breeds and commercial populations. The results suggested that further studies are needed with regard to the genetic resistance to avian influenza in different populations with various domestication background and selection history. PMID:16830876

  4. Next Generation Sequencing Reveals Skewing of the T and B Cell Receptor Repertoires in Patients with Wiskott–Aldrich Syndrome

    PubMed Central

    O’Connell, Amy E.; Volpi, Stefano; Dobbs, Kerry; Fiorini, Claudia; Tsitsikov, Erdyni; de Boer, Helen; Barlan, Isil B.; Despotovic, Jenny M.; Espinosa-Rosales, Francisco J.; Hanson, I. Celine; Kanariou, Maria G.; Martínez-Beckerat, Roxana; Mayorga-Sirera, Alvaro; Mejia-Carvajal, Carmen; Radwan, Nesrine; Weiss, Aaron R.; Pai, Sung-Yun; Lee, Yu Nee; Notarangelo, Luigi D.

    2014-01-01

    The Wiskott–Aldrich syndrome (WAS) is due to mutations of the WAS gene encoding for the cytoskeletal WAS protein, leading to abnormal downstream signaling from the T cell and B cell antigen receptors (TCR and BCR). We hypothesized that the impaired signaling through the TCR and BCR in WAS would subsequently lead to aberrations in the immune repertoire of WAS patients. Using next generation sequencing (NGS), the T cell receptor β and B cell immunoglobulin heavy chain (IGH) repertoires of eight patients with WAS and six controls were sequenced. Clonal expansions were identified within memory CD4+ cells as well as in total, naïve and memory CD8+ cells from WAS patients. In the B cell compartment, WAS patient IGH repertoires were also clonally expanded and showed skewed usage of IGHV and IGHJ genes, and increased usage of IGHG constant genes, compared with controls. To our knowledge, this is the first study that demonstrates significant abnormalities of the immune repertoire in WAS patients using NGS. PMID:25101082

  5. Effects of rotation on coolant passage heat transfer. Volume 2: Coolant passages with trips normal and skewed to the flow

    NASA Technical Reports Server (NTRS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.

    1993-01-01

    An experimental program was conducted to investigate heat transfer and pressure loss characteristics of rotating multipass passages, for configurations and dimensions typical of modem turbine blades. This experimental program is one part of the NASA Hot Section Technology (HOST) Initiative, which has as its overall objective the development and verification of improved analysis methods that will form the basis for a design system that will produce turbine components with improved durability. The objective of this program was the generation of a data base of heat transfer and pressure loss data required to develop heat transfer correlations and to assess computational fluid dynamic techniques for rotating coolant passages. The experimental work was broken down into two phases. Phase 1 consists of experiments conducted in a smooth wall large scale heat transfer model. A detailed discussion of these results was presented in volume 1 of a NASA Report. In Phase 2 the large scale model was modified to investigate the effects of skewed and normal passage turbulators. The results of Phase 2 along with comparison to Phase 1 is the subject of this Volume 2 NASA Report.

  6. Skewed Differentiation of Circulating Vγ9Vδ2 T Lymphocytes in Melanoma and Impact on Clinical Outcome

    PubMed Central

    Toia, Francesca; Buccheri, Simona; Anfosso, Ampelio; Moschella, Francesco; Dieli, Francesco; Meraviglia, Serena; Cordova, Adriana

    2016-01-01

    Objective The aim of this study was to evaluate over time circulating γδ T lymphocytes in melanoma patients in terms of frequency, effector functions, and relationship with clinical stage and evolution, by comparing preoperative values to those obtained at a mean follow-up of 36 months or in the event of recurrence or disease progression, and to those of healthy controls. Also, we correlated the presence of tumor-infiltrating γδ T lymphocytes with clinical evolution of melanoma. Results Mean frequencies of circulating γδ T cells before and after melanoma removal were very similar and comparable to healthy subjects, but patients who progressed to stage III or IV showed a significantly decreased frequency of circulating Vγ9Vδ2 T cells. The distribution of Vγ9Vδ2 memory and effector subsets was similar in healthy subjects and melanoma patients at diagnosis, but circulating γδ T cells of patients after melanoma removal had a skewed terminally-differentiated effector memory phenotype. Highly suggestive of progressive differentiation toward a cytotoxic phenotype, Vγ9Vδ2T cells from patients at follow up had increased cytotoxic potential and limited cytokine production capability, while the opposite pattern was detected in Vγ9Vδ2T cells from patients before melanoma removal. Conclusions Follow-up data also showed that tumor infiltrating γδ T cells were significantly associated with lower mortality and relapse rates, suggesting that they may serve as a prognostic biomarker, for human melanoma. PMID:26915072

  7. Numerical Treatment of a Skew-Derivative Problem for the Laplace Equation in the Exterior of Open Arcs: One-Point Scheme

    NASA Astrophysics Data System (ADS)

    Kolybasova, V. V.; Krutitskii, P. A.

    2010-09-01

    We consider a skew derivative problem for a function which is harmonic in the exterior of open arcs in a plane. This problem models electric current in a semiconductor film from electrodes of arbitrary shapes in the presence of a magnetic field. A numerical method for solving the problem is proposed. The method is based on the boundary integral equation approach. The proposed numerical method is tested for different values of parameters and different shapes of the electrodes.

  8. A novel skew analysis reveals substitution asymmetries linked to genetic code GC-biases and PolIII a-subunit isoforms

    PubMed Central

    Apostolou-Karampelis, Konstantinos; Nikolaou, Christoforos; Almirantis, Yannis

    2016-01-01

    Strand biases reflect deviations from a null expectation of DNA evolution that assumes strand-symmetric substitution rates. Here, we present strong evidence that nearest-neighbour preferences are a strand-biased feature of bacterial genomes, indicating neighbour-dependent substitution asymmetries. To detect such asymmetries we introduce an alignment free index (relative abundance skews). The profiles of relative abundance skews along coding sequences can trace the phylogenetic relations of bacteria, suggesting that the patterns of neighbour-dependent substitution strand-biases are not common among different lineages, but are rather species-specific. Analysis of neighbour-dependent and codon-site skews sheds light on the origins of substitution asymmetries. Via a simple model we argue that the structure of the genetic code imposes position-dependent substitution strand-biases along coding sequences, as a response to GC mutation pressure. Thus, the organization of the genetic code per se can lead to an uneven distribution of nucleotides among different codon sites, even when requirements for specific codons and amino-acids are not accounted for. Moreover, our results suggest that strand-biases in replication fidelity of PolIII α-subunit induce substitution asymmetries, both neighbour-dependent and independent, on a genome scale. The role of DNA repair systems, such as transcription-coupled repair, is also considered. PMID:27345720

  9. Digital-map grids of mean-annual precipitation for 1961-90, and generalized skew coefficients of annual maximum streamflow for Oklahoma

    USGS Publications Warehouse

    Rea, A.H.; Tortorelli, R.L.

    1997-01-01

    This digital report contains two digital-map grids of data that were used to develop peak-flow regression equations in Tortorelli, 1997, 'Techniques for estimating peak-streamflow frequency for unregulated streams and streams regulated by small floodwater retarding structures in Oklahoma,' U.S. Geological Survey Water-Resources Investigations Report 97-4202. One data set is a grid of mean annual precipitation, in inches, based on the period 1961-90, for Oklahoma. The data set was derived from the PRISM (Parameter-elevation Regressions on Independent Slopes Model) mean annual precipitation grid for the United States, developed by Daly, Neilson, and Phillips (1994, 'A statistical-topographic model for mapping climatological precipitation over mountainous terrain:' Journal of Applied Meteorology, v. 33, no. 2, p. 140-158). The second data set is a grid of generalized skew coefficients of logarithms of annual maximum streamflow for Oklahoma streams less than or equal to 2,510 square miles in drainage area. This grid of skew coefficients is taken from figure 11 of Tortorelli and Bergman, 1985, 'Techniques for estimating flood peak discharges for unregulated streams and streams regulated by small floodwater retarding structures in Oklahoma,' U.S. Geological Survey Water-Resources Investigations Report 84-4358. To save disk space, the skew coefficient values have been multiplied by 100 and rounded to integers with two significant digits. The data sets are provided in an ASCII grid format.

  10. Highly skewed sex ratios and biased fossil deposition of moa: ancient DNA provides new insight on New Zealand's extinct megafauna

    NASA Astrophysics Data System (ADS)

    Allentoft, Morten E.; Bunce, Michael; Scofield, R. Paul; Hale, Marie L.; Holdaway, Richard N.

    2010-03-01

    Ancient DNA was isolated from the bones of 267 individuals of the extinct New Zealand moa (Aves: Dinornithiformes) from two late Holocene deposits [Pyramid Valley (PV) and Bell Hill Vineyard (BHV)] located 5.7 km apart in North Canterbury, South Island. The two sites' combined fossil record cover the last 3000 years of pre-human New Zealand and mitochondrial DNA confirmed that four species ( Dinornis robustus, Euryapteryx curtus, Emeus crassus, and Pachyornis elephantopus) were sympatric in the region. However, the relative species compositions in the two deposits differed significantly with D. robustus and E. crassus being most abundant at PV while E. curtus outnumbered the other three moa taxa combined at BHV. A subsample of 227 individuals had sufficient nuclear DNA preservation to warrant the use of molecular sexing techniques, and the analyses uncovered a remarkable excess of females in both deposits with an overall male to female ratio of 1:5.1. Among juveniles of E. curtus, the only species which was represented by a substantial fraction of juveniles, the sex ratio was not skewed (10 ♂, 10 ♀), suggesting that the observed imbalance arose as a result of differential mortality during maturation. Surprisingly, sex ratios proved significantly different between sites with a 1:2.2 ratio at BHV ( n = 90) and 1:14.2 at PV ( n = 137). Given the mobility of large ratites, and the proximity of the two fossil assemblages in space and time, these differences in taxonomic and gender composition indicate that moa biology and the local environment have affected the fossil representation dramatically and several possible explanations are offered. Apart from adding to our understanding of moa biology, these discoveries reinforce the need for caution when basing interpretation of the fossil record on material from a single site.

  11. HIV Skews the Lineage-Defining Transcriptional Profile of Mycobacterium tuberculosis-Specific CD4+ T Cells.

    PubMed

    Riou, Catherine; Strickland, Natalie; Soares, Andreia P; Corleis, Björn; Kwon, Douglas S; Wherry, E John; Wilkinson, Robert J; Burgers, Wendy A

    2016-04-01

    HIV-infected persons are at greater risk of developing tuberculosis (TB) even before profound CD4 loss occurs, suggesting that HIV alters CD4(+) T cell functions capable of containing bacterial replication. An effective immune response to Mycobacterium tuberculosis most likely relies on the development of a balanced CD4 response, in which distinct CD4(+) Th subsets act in synergy to control the infection. To define the diversity of M. tuberculosis-specific CD4(+) Th subsets and determine whether HIV infection impacts such responses, the expression of lineage-defining transcription factors T-bet, Gata3, RORγt, and Foxp3 was measured in M. tuberculosis-specific CD4(+) T cells in HIV-uninfected (n = 20) and HIV-infected individuals (n = 20) with latent TB infection. Our results show that, upon 5-d restimulation in vitro, M. tuberculosis-specific CD4(+) T cells from healthy individuals have the ability to exhibit a broad spectrum of Th subsets, defined by specific patterns of transcription factor coexpression. These transcription factor profiles were skewed in HIV-infected individuals where the proportion of T-bet(high)Foxp3(+) M. tuberculosis-specific CD4(+) T cells was significantly decreased (p = 0.002) compared with HIV-uninfected individuals, a change that correlated inversely with HIV viral load (p = 0.0007) and plasma TNF-α (p = 0.027). Our data demonstrate an important balance in Th subset diversity defined by lineage-defining transcription factor coexpression profiles that is disrupted by HIV infection and suggest a role for HIV in impairing TB immunity by altering the equilibrium of M. tuberculosis-specific CD4(+) Th subsets. PMID:26927799

  12. p-hacking by post hoc selection with multiple opportunities: Detectability by skewness test?: Comment on Simonsohn, Nelson, and Simmons (2014).

    PubMed

    Ulrich, Rolf; Miller, Jeff

    2015-12-01

    Simonsohn, Nelson, and Simmons (2014) have suggested a novel test to detect p-hacking in research, that is, when researchers report excessive rates of "significant effects" that are truly false positives. Although this test is very useful for identifying true effects in some cases, it fails to identify false positives in several situations when researchers conduct multiple statistical tests (e.g., reporting the most significant result). In these cases, p-curves are right-skewed, thereby mimicking the existence of real effects even if no effect is actually present. PMID:26595841

  13. Flexible mixture modeling via the multivariate t distribution with the Box-Cox transformation: an alternative to the skew-t distribution.

    PubMed

    Lo, Kenneth; Gottardo, Raphael

    2012-01-01

    Cluster analysis is the automated search for groups of homogeneous observations in a data set. A popular modeling approach for clustering is based on finite normal mixture models, which assume that each cluster is modeled as a multivariate normal distribution. However, the normality assumption that each component is symmetric is often unrealistic. Furthermore, normal mixture models are not robust against outliers; they often require extra components for modeling outliers and/or give a poor representation of the data. To address these issues, we propose a new class of distributions, multivariate t distributions with the Box-Cox transformation, for mixture modeling. This class of distributions generalizes the normal distribution with the more heavy-tailed t distribution, and introduces skewness via the Box-Cox transformation. As a result, this provides a unified framework to simultaneously handle outlier identification and data transformation, two interrelated issues. We describe an Expectation-Maximization algorithm for parameter estimation along with transformation selection. We demonstrate the proposed methodology with three real data sets and simulation studies. Compared with a wealth of approaches including the skew-t mixture model, the proposed t mixture model with the Box-Cox transformation performs favorably in terms of accuracy in the assignment of observations, robustness against model misspecification, and selection of the number of components. PMID:22125375

  14. Expected constraints on models of the epoch of reionization with the variance and skewness in redshifted 21 cm-line fluctuations

    NASA Astrophysics Data System (ADS)

    Kubota, Kenji; Yoshiura, Shintaro; Shimabukuro, Hayato; Takahashi, Keitaro

    2016-06-01

    The redshifted 21 cm-line signal from neutral hydrogen in the intergalactic medium (IGM) gives a direct probe of the epoch of reionization (EoR). In this paper, we investigate the potential of the variance and skewness of the probability distribution function of the 21 cm brightness temperature for constraining EoR models. These statistical quantities are simple, easy to calculate from the observed visibility, and thus suitable for the early exploration of the EoR with current telescopes such as the Murchison Widefield Array (MWA) and LOw Frequency ARray (LOFAR). We show, by performing Fisher analysis, that the variance and skewness at z = 7-9 are complementary to each other to constrain the EoR model parameters such as the minimum virial temperature of halos which host luminous objects, ionizing efficiency, and mean free path of ionizing photons in the IGM. Quantitatively, the constraining power highly depends on the quality of the foreground subtraction and calibration. We give a best case estimate of the constraints on the parameters, neglecting the systematics other than the thermal noise.

  15. Three-dimensional thermal and fluid mixing analysis using the mass-flow-weighted skew-upwind differencing scheme. Final report. [PWR

    SciTech Connect

    Hassan, Y.A.

    1985-02-01

    The upwind finite difference scheme used in the COMMIX-1A code to approximate the convective transport term was shown to contribute more artificial diffusivity to the computed temperature field than the total physical diffusivity that could be inferred from experimental observations of the thermal mixing processes. With aim to reduce such numerical error, a new finite difference scheme called the mass-flow-weighted skew-upwind approach was developed, incorporated in COMMIX-1A, and evaluated by comparison with known analytical solutions and experimental data. This report describes the follow-on activities pursued to demonstrate the applicability of the new finite difference scheme to simulations of pressurized thermal shock events. These activities include benchmarking the code against the Creare one-fifth-scale test 51 and simulating mixing in the full-scale cold leg and downcomer of a Babcock and Wilcox plant using both the upwind and the mass-flow-weighted skew-upwind finite difference scehmes. The new scheme is shown to considerably reduce the amount of artifical diffusivity contributed to the computed temperature field by the convective term approximation.

  16. Atacama Cosmology Telescope: A measurement of the thermal Sunyaev-Zel'dovich effect using the skewness of the CMB temperature distribution

    NASA Astrophysics Data System (ADS)

    Wilson, Michael J.; Sherwin, Blake D.; Hill, J. Colin; Addison, Graeme; Battaglia, Nick; Bond, J. Richard; Das, Sudeep; Devlin, Mark J.; Dunkley, Joanna; Dünner, Rolando; Fowler, Joseph W.; Gralla, Megan B.; Hajian, Amir; Halpern, Mark; Hilton, Matt; Hincks, Adam D.; Hlozek, Renée; Huffenberger, Kevin; Hughes, John P.; Kosowsky, Arthur; Louis, Thibaut; Marriage, Tobias A.; Marsden, Danica; Menanteau, Felipe; Moodley, Kavilan; Niemack, Michael D.; Nolta, Michael R.; Page, Lyman A.; Partridge, Bruce; Reese, Erik D.; Sehgal, Neelima; Sievers, Jon; Spergel, David N.; Staggs, Suzanne T.; Swetz, Daniel S.; Switzer, Eric R.; Trac, Hy; Wollack, Ed

    2012-12-01

    We present a detection of the unnormalized skewness ⟨T˜3(n^)⟩ induced by the thermal Sunyaev-Zel’dovich (tSZ) effect in filtered Atacama Cosmology Telescope (ACT) 148 GHz cosmic microwave background temperature maps. Contamination due to infrared and radio sources is minimized by template subtraction of resolved sources and by constructing a mask using outlying values in the 218 GHz (tSZ-null) ACT maps. We measure ⟨T˜3(n^)⟩=-31±6μK3 (Gaussian statistics assumed) or ±14μK3 (including non-Gaussian corrections) in the filtered ACT data, a 5σ detection. We show that the skewness is a sensitive probe of σ8, and use analytic calculations and tSZ simulations to obtain cosmological constraints from this measurement. From this signal alone we infer a value of σ8=0.79-0.03+0.03 (68% C.L.) ​-0.06+0.06 (95% C.L.). Our results demonstrate that measurements of non-Gaussianity can be a useful method for characterizing the tSZ effect and extracting the underlying cosmological information.

  17. The Atacama Cosmology Telescope: A Measurement of the Thermal Sunyaev-Zel'dovich Effect Using the Skewness of the CMB Temperature Distribution

    NASA Technical Reports Server (NTRS)

    Wilson, Michael J.; Sherwin, Blake D.; Hill, J. Collin; Addison, Graeme; Battaglia, Nick; Bond, J. Richard; Das, Sudeep; Devlin, Mark J.; Dunkley, Joanna; Duenner, Rolando; Fowler, Joseph W.; Gralla, Megan, B.; Hajian, Amir; Halpern, Mark; Hilton, Matt; Hincks, Adam D.; Hlozek, Renee; Huffenberger, Kevin; Hughes, John P.; Kosowsky, Arthur; Louis, Thibaut; Marriage, Tobias A.; Marsden, Danica; Menanteau, Felipe; Wollack, Ed

    2012-01-01

    We present a detection of the unnormalized skewness (T(sup )(sup 2)(n(circumflex)) induced by the thermal Sunyaev-Zel'dovich (tSZ) effect in filtered Atacama Cosmology Telescope (ACT) 148 GHz cosmic microwave background temperature maps. Contamination due to infrared and radio sources is minimized by template subtraction of resolved sources and by constructing a mask using outlying values in the 218 GHz (tSZ-null) ACT maps. We measure (T(sup )(sup 3) (n(circumflex)) = -31 plus or minus 6 micro-K(sup 3) (measurement error only) or plus or minus 14 micro-K(sup 3) (including cosmic variance error) in the filtered ACT data, a 5sigma detection. We show that the skewness is a sensitive probe of sigma(sub 8), and use analytic calculations and tSZ simulations to obtain cosmological constraints from this measurement. From this signal alone we infer a value of sigma(sub 8) = 0.78 sup +0.03 sub -0.04 (68% C.L.) sup +0.05 sub -0.16. Our results demonstrate that measurements of nonGaussianity can be a useful method for characterizing the tSZ effect and extracting the underlying cosmological information.

  18. 2.5 Gbps clock data recovery using 1/4th-rate quadricorrelator frequency detector and skew-calibrated multi-phase clock generator

    NASA Astrophysics Data System (ADS)

    Tontisirin, S.; Tielert, R.

    2006-09-01

    A Gb/s clock and data recovery (CDR) circuit using 1/4th-rate digital quadricorrelator frequency detector and skew-calibrated multi-phase voltage-controlled oscillator is presented. With 1/4th-rate clock architecture, the coil-free oscillator can have lower operation frequency providing sufficient low-jitter operation. Moreover, it is an inherent 1-to-4 DEMUX. The skew calibration scheme is applied to reduce phase offset in multi-phase clock generator. The CDR with frequency detector can have small loop bandwidth, wide pull-in range and can operate without the need for a local reference clock. This 1/4th-rate CDR is implemented in standard 0.18 μm CMOS technology. It has an active area of 0.7 mm2 and consumes 100 mW at 1.8 V supply. The CDR has low jitter operation in a wide frequency range from 1-2.25 Gb/s. Measurement of Bit-Error Rate is less than 10-12 for 2.25 Gb/s incoming data 27-1 PRBS, jitter peak-to-peak of 0.7 unit interval (UI) modulation at 10 MHz.

  19. Skew-t fits to mortality data--can a Gaussian-related distribution replace the Gompertz-Makeham as the basis for mortality studies?

    PubMed

    Clark, Jeremy S C; Kaczmarczyk, Mariusz; Mongiało, Zbigniew; Ignaczak, Paweł; Czajkowski, Andrzej A; Klęsk, Przemysław; Ciechanowicz, Andrzej

    2013-08-01

    Gompertz-related distributions have dominated mortality studies for 187 years. However, nonrelated distributions also fit well to mortality data. These compete with the Gompertz and Gompertz-Makeham data when applied to data with varying extents of truncation, with no consensus as to preference. In contrast, Gaussian-related distributions are rarely applied, despite the fact that Lexis in 1879 suggested that the normal distribution itself fits well to the right of the mode. Study aims were therefore to compare skew-t fits to Human Mortality Database data, with Gompertz-nested distributions, by implementing maximum likelihood estimation functions (mle2, R package bbmle; coding given). Results showed skew-t fits obtained lower Bayesian information criterion values than Gompertz-nested distributions, applied to low-mortality country data, including 1711 and 1810 cohorts. As Gaussian-related distributions have now been found to have almost universal application to error theory, one conclusion could be that a Gaussian-related distribution might replace Gompertz-related distributions as the basis for mortality studies. PMID:23233550

  20. Expected constraints on models of the epoch of reionization with the variance and skewness in redshifted 21 cm-line fluctuations

    NASA Astrophysics Data System (ADS)

    Kubota, Kenji; Yoshiura, Shintaro; Shimabukuro, Hayato; Takahashi, Keitaro

    2016-08-01

    The redshifted 21 cm-line signal from neutral hydrogen in the intergalactic medium (IGM) gives a direct probe of the epoch of reionization (EoR). In this paper, we investigate the potential of the variance and skewness of the probability distribution function of the 21 cm brightness temperature for constraining EoR models. These statistical quantities are simple, easy to calculate from the observed visibility, and thus suitable for the early exploration of the EoR with current telescopes such as the Murchison Widefield Array (MWA) and LOw Frequency ARray (LOFAR). We show, by performing Fisher analysis, that the variance and skewness at z = 7-9 are complementary to each other to constrain the EoR model parameters such as the minimum virial temperature of halos which host luminous objects, ionizing efficiency, and mean free path of ionizing photons in the IGM. Quantitatively, the constraining power highly depends on the quality of the foreground subtraction and calibration. We give a best case estimate of the constraints on the parameters, neglecting the systematics other than the thermal noise.

  1. Estimation of flood discharges at selected annual exceedance probabilities for unregulated, rural streams in Vermont, with a section on Vermont regional skew regression

    USGS Publications Warehouse

    Olson, Scott A.; with a section by Veilleux, Andrea G.

    2014-01-01

    This report provides estimates of flood discharges at selected annual exceedance probabilities (AEPs) for streamgages in and adjacent to Vermont and equations for estimating flood discharges at AEPs of 50-, 20-, 10-, 4-, 2-, 1-, 0.5-, and 0.2-percent (recurrence intervals of 2-, 5-, 10-, 25-, 50-, 100-, 200-, and 500-years, respectively) for ungaged, unregulated, rural streams in Vermont. The equations were developed using generalized least-squares regression. Flood-frequency and drainage-basin characteristics from 145 streamgages were used in developing the equations. The drainage-basin characteristics used as explanatory variables in the regression equations include drainage area, percentage of wetland area, and the basin-wide mean of the average annual precipitation. The average standard errors of prediction for estimating the flood discharges at the 50-, 20-, 10-, 4-, 2-, 1-, 0.5-, and 0.2-percent AEP with these equations are 34.9, 36.0, 38.7, 42.4, 44.9, 47.3, 50.7, and 55.1 percent, respectively. Flood discharges at selected AEPs for streamgages were computed by using the Expected Moments Algorithm. To improve estimates of the flood discharges for given exceedance probabilities at streamgages in Vermont, a new generalized skew coefficient was developed. The new generalized skew for the region is a constant, 0.44. The mean square error of the generalized skew coefficient is 0.078. This report describes a technique for using results from the regression equations to adjust an AEP discharge computed from a streamgage record. This report also describes a technique for using a drainage-area adjustment to estimate flood discharge at a selected AEP for an ungaged site upstream or downstream from a streamgage. The final regression equations and the flood-discharge frequency data used in this study will be available in StreamStats. StreamStats is a World Wide Web application providing automated regression-equation solutions for user-selected sites on streams.

  2. Method and structure for skewed block-cyclic distribution of lower-dimensional data arrays in higher-dimensional processor grids

    DOEpatents

    Chatterjee, Siddhartha; Gunnels, John A.

    2011-11-08

    A method and structure of distributing elements of an array of data in a computer memory to a specific processor of a multi-dimensional mesh of parallel processors includes designating a distribution of elements of at least a portion of the array to be executed by specific processors in the multi-dimensional mesh of parallel processors. The pattern of the designating includes a cyclical repetitive pattern of the parallel processor mesh, as modified to have a skew in at least one dimension so that both a row of data in the array and a column of data in the array map to respective contiguous groupings of the processors such that a dimension of the contiguous groupings is greater than one.

  3. Hydrologic and geochemical data collected near Skewed Reservoir, an impoundment for coal-bed natural gas produced water, Powder River Basin, Wyoming

    USGS Publications Warehouse

    Healy, Richard W.; Rice, Cynthia A.; Bartos, Timothy T.

    2012-01-01

    The Powder River Structural Basin is one of the largest producers of coal-bed natural gas (CBNG) in the United States. An important environmental concern in the Basin is the fate of groundwater that is extracted during CBNG production. Most of this produced water is disposed of in unlined surface impoundments. A 6-year study of groundwater flow and subsurface water and soil chemistry was conducted at one such impoundment, Skewed Reservoir. Hydrologic and geochemical data collected as part of that study are contained herein. Data include chemistry of groundwater obtained from a network of 21 monitoring wells and three suction lysimeters and chemical and physical properties of soil cores including chemistry of water/soil extracts, particle-size analyses, mineralogy, cation-exchange capacity, soil-water content, and total carbon and nitrogen content of soils.

  4. Heavy metal mediated innate immune responses of the Indian green frog, Euphlyctis hexadactylus (Anura: Ranidae): Cellular profiles and associated Th1 skewed cytokine response.

    PubMed

    Jayawardena, Uthpala A; Ratnasooriya, Wanigasekara D; Wickramasinghe, Deepthi D; Udagama, Preethi V

    2016-10-01

    Immune cell and cytokine profiles in relation to metal exposure though much studied in mammals has not been adequately investigated in amphibians, due mainly to lack of suitable reagents for cytokine profiling in non-model species. However, interspecies cross reactivity of cytokines permitted us to assay levels of IFNγ, TNFα, IL6 and IL10in a common anuran, the Indian green frog (Euphlyctis hexadactylus), exposed to heavy metals (Cd, Cr, Cu, Zn and Pb, at ~5ppm each) under field and laboratory settings in Sri Lanka. Enumeration of immune cells in blood and melanomacrophages in the liver, assay of serum and hepatic cytokines, and Th1/Th2 cytokine polarisation were investigated. Immune cell counts indicated overall immunosuppression with decreasing total WBC and splenocyte counts while neutrophil/lymphocyte ratio increased with metal exposure, indicating metal mediated stress. Serum IL6 levels of metal exposed frogs reported the highest (~9360pg/mL) of all cytokines tested. Significantly elevated IFNγ production (P<0.05) was evident in heavy metal exposed frogs. Th1/Th2 cytokine ratio in both serum and liver tissue homogenates was Th1 skewed due to significantly higher production of pro-inflammatory cytokines, IFNγ in serum and TNFα in the liver (P<0.01).Metal mediated aggregations of melanomacrophages in the liver were positively and significantly (P<0.05) correlated with the hepatic expression of TNFα, IL6 and IL10 activity. Overall, Th1 skewed response may well be due to oxidative stress mediated nuclear factor κ-light chain enhancer of activated B cells (NFκB) which enhances the transcription of pro-inflammatory cytokines. Xenobiotic stress has recently imposed an unprecedented level of threat to wildlife, particularly to sensitive species such as amphibians. Therefore, understanding the interactions between physiological stress and related immune responses is fundamental to conserve these environmental sentinels in the face of emerging eco

  5. Incorporation of 5-ethynyl-2'-deoxyuridine (EdU) as a novel strategy for identification of the skewed X inactivation pattern in balanced and unbalanced X-rearrangements.

    PubMed

    Sisdelli, Luiza; Vidi, Angela Cristina; Moysés-Oliveira, Mariana; Di Battista, Adriana; Bortolai, Adriana; Moretti-Ferreira, Danilo; da Silva, Magnus R Dias; Melaragno, Maria Isabel; Carvalheira, Gianna

    2016-02-01

    X-chromosome inactivation occurs randomly in normal female cells. However, the inactivation can be skewed in patients with alterations in X-chromosome. In balanced X-autosome translocations, normal X is preferentially inactivated, while in unbalanced X alterations, the aberrant X is usually inactivated. Here, we present a novel strategy to verify the skewed X inactivation pattern through the incorporation of 5-ethynyl-2'-deoxyuridine (EdU) into cells, in 11 patients: five carriers of balanced X-autosome translocations and six of unbalanced X-chromosome alterations. Since EdU is a labeled nucleoside analog of thymidine, its incorporation during DNA synthesis can reveal late replication regions and the inactive X-chromosome. All EdU findings were validated by the human androgen receptor gene (HUMARA) assay. The late replication regions were easily and quickly visualized in all cells, where inactive Xs are marked with strong green fluorescence. It was observed that the normal X-chromosome was preferentially inactivated in patients with balanced X-autosome translocations; while the aberrant X-chromosome was inactivated in most cells from patients with unbalanced alterations. By performing the fluorescence-based EdU assay, the differences between the active and inactive X-chromosomes are more easily recognizable than by classic cytogenetic methods. Furthermore, EdU incorporation allows the observation of the late replication regions in autosomal segments present in X derivatives from X-autosome translocations. Therefore, EdU assay permits an accurate and efficient cytogenetic evaluation of the X inactivation pattern with a low-cost, easy to perform and highly reproducible technique. PMID:26670424

  6. Role of Aspergillus fumigatus in Triggering Protease-Activated Receptor-2 in Airway Epithelial Cells and Skewing the Cells toward a T-helper 2 Bias.

    PubMed

    Homma, Tetsuya; Kato, Atsushi; Bhushan, Bharat; Norton, James E; Suh, Lydia A; Carter, Roderick G; Gupta, Dave S; Schleimer, Robert P

    2016-01-01

    Aspergillus fumigatus (AF) infection and sensitization are common and promote Th2 disease in individuals with asthma. Innate immune responses of bronchial epithelial cells are now known to play a key role in determination of T cell responses upon encounter with inhaled pathogens. We have recently shown that extracts of AF suppress JAK-STAT signaling in epithelial cells and thus may promote Th2 bias. To elucidate the impact of AF on human bronchial epithelial cells, we tested the hypothesis that AF can modulate the response of airway epithelial cells to favor a Th2 response and explored the molecular mechanism of the effect. Primary normal human bronchial epithelial (NHBE) cells were treated with AF extract or fractionated AF extract before stimulation with poly I:C or infection with human rhinovirus serotype 16 (HRV16). Expression of CXCL10 mRNA (real-time RT-PCR) and protein (ELISA) were measured as markers of IFN-mediated epithelial Th1-biased responses. Western blot was performed to evaluate expression of IFN regulatory factor-3 (IRF-3), NF-κB, and tyrosine-protein phosphatase nonreceptor type 11 (PTPN11), which are other markers of Th1 skewing. Knockdown experiments for protease-activated receptor-2 (PAR-2) and PTPN11 were performed to analyze the role of PAR-2 in the mechanism of suppression by AF. AF and a high-molecular-weight fraction of AF extract (HMW-AF; > 50 kD) profoundly suppressed poly I:C- and HRV16-induced expression of both CXCL10 mRNA and protein from NHBE cells via a mechanism that relied upon PAR-2 activation. Both AF extract and a specific PAR-2 activator (AC-55541) suppressed the poly I:C activation of phospho-IRF-3 without affecting activation of NF-κB. Furthermore, HMW-AF extract enhanced the expression of PTPN11, a phosphatase known to inhibit IFN signaling, and concurrently suppressed poly I:C-induced expression of both CXCL10 mRNA and protein from NHBE cells. These results show that exposure of bronchial epithelial cells to AF extract

  7. The LMNA mutation p.Arg321Ter associated with dilated cardiomyopathy leads to reduced expression and a skewed ratio of lamin A and lamin C proteins

    SciTech Connect

    Al-Saaidi, Rasha; Rasmussen, Torsten B.; Palmfeldt, Johan; Nissen, Peter H.; Beqqali, Abdelaziz; Hansen, Jakob; Pinto, Yigal M.; Boesen, Thomas; Mogensen, Jens; Bross, Peter

    2013-11-15

    heterozygosity for the nonsense mutation causes NMD degradation of the mutant transcripts blocking expression of the truncated mutant protein and an additional trans effect on lamin A protein levels expressed from the wild type allele. We discuss the possibility that skewing of the lamin A to lamin C ratio may contribute to ensuing processes that destabilize cardiomyocytes and trigger cardiomyopathy - Highlights: • We study disease mechanisms in DCM patients carrying PTC mutations in the LMNA gene. • The mutant transcript is degraded by the nonsense mediated mRNA decay system. • Skewed lamin A to lamin C protein ratio expressed from the wild type allele. • We suggest a combined pathomechanism: haploinsuffiency plus lamin A/C imbalance.

  8. A Single HIV-1 Cluster and a Skewed Immune Homeostasis Drive the Early Spread of HIV among Resting CD4+ Cell Subsets within One Month Post-Infection

    PubMed Central

    Avettand-Fenoël, Véronique; Nembot, Georges; Mélard, Adeline; Blanc, Catherine; Lascoux-Combe, Caroline; Slama, Laurence; Allegre, Thierry; Allavena, Clotilde; Yazdanpanah, Yazdan; Duvivier, Claudine; Katlama, Christine; Goujard, Cécile; Seksik, Bao Chau Phung; Leplatois, Anne; Molina, Jean-Michel; Meyer, Laurence; Autran, Brigitte; Rouzioux, Christine

    2013-01-01

    Optimizing therapeutic strategies for an HIV cure requires better understanding the characteristics of early HIV-1 spread among resting CD4+ cells within the first month of primary HIV-1 infection (PHI). We studied the immune distribution, diversity, and inducibility of total HIV-DNA among the following cell subsets: monocytes, peripheral blood activated and resting CD4 T cells, long-lived (naive [TN] and central-memory [TCM]) and short-lived (transitional-memory [TTM] and effector-memory cells [TEM]) resting CD4+T cells from 12 acutely-infected individuals recruited at a median 36 days from infection. Cells were sorted for total HIV-DNA quantification, phylogenetic analysis and inducibility, all studied in relation to activation status and cell signaling. One month post-infection, a single CCR5-restricted viral cluster was massively distributed in all resting CD4+ subsets from 88% subjects, while one subject showed a slight diversity. High levels of total HIV-DNA were measured among TN (median 3.4 log copies/million cells), although 10-fold less (p = 0.0005) than in equally infected TCM (4.5), TTM (4.7) and TEM (4.6) cells. CD3−CD4+ monocytes harbored a low viral burden (median 2.3 log copies/million cells), unlike equally infected resting and activated CD4+ T cells (4.5 log copies/million cells). The skewed repartition of resting CD4 subsets influenced their contribution to the pool of resting infected CD4+T cells, two thirds of which consisted of short-lived TTM and TEM subsets, whereas long-lived TN and TCM subsets contributed the balance. Each resting CD4 subset produced HIV in vitro after stimulation with anti-CD3/anti-CD28+IL-2 with kinetics and magnitude varying according to subset differentiation, while IL-7 preferentially induced virus production from long-lived resting TN cells. In conclusion, within a month of infection, a clonal HIV-1 cluster is massively distributed among resting CD4 T-cell subsets with a flexible inducibility, suggesting that

  9. Niacin and olive oil promote skewing to the M2 phenotype in bone marrow-derived macrophages of mice with metabolic syndrome.

    PubMed

    Montserrat-de la Paz, Sergio; Naranjo, Maria C; Lopez, Sergio; Abia, Rocio; Muriana, Francisco J G; Bermudez, Beatriz

    2016-05-18

    Metabolic syndrome (MetS) is associated with obesity, dyslipemia, type 2 diabetes and chronic low-grade inflammation. The aim of this study was to determine the role of high-fat low-cholesterol diets (HFLCDs) rich in SFAs (HFLCD-SFAs), MUFAs (HFLCD-MUFAs) or MUFAs plus omega-3 long-chain PUFAs (HFLCD-PUFAs) on polarisation and inflammatory potential in bone marrow-derived macrophages (BMDMs) from niacin (NA)-treated Lep(ob/ob)LDLR(-/-) mice. Animals fed with HFLCD-SFAs had increased weight and serum triglycerides, and their BMDMs accumulated triglycerides over the animals fed with HFLCD-MUFAs or -PUFAs. Furthermore, BMDMs from animals fed with HFLCD-SFAs were polarised towards the M1 phenotype with functional competence to produce pro-inflammatory cytokines, whereas BMDMs from animals fed with HFLCD-MUFAs or -PUFAs were skewed to the anti-inflammatory M2 phenotype. These findings open opportunities for developing novel nutritional strategies with olive oil as the most important dietary source of MUFAs (notably oleic acid) to prevent development and progression of metabolic complications in the NA-treated MetS. PMID:27116638

  10. Treatment to sustain a Th17-type phenotype to prevent skewing toward Treg and to limit premalignant lesion progression to cancer.

    PubMed

    Young, M Rita I; Levingston, Corinne A; Johnson, Sara D

    2016-05-15

    While immune suppression is a hallmark of head and neck squamous cell carcinoma (HSNCC), the immunological impact of premalignant oral lesions, which often precedes development of HNSCC, is unknown. The present study assessed the changes in splenic and draining lymph node CD4(+) cell populations and their production of select cytokines that occur in mice with carcinogen-induced premalignant oral lesions and the changes that occur as lesions progress to oral cancer. These studies found skewing toward Th1 and Th17-type phenotypes in the spleen and lymph nodes of mice with premalignant oral lesions and a shift to Treg as lesions progress to cancer. Since the role of Th17 cells in the progression from premalignant lesions to cancer is not clear, studies determined the immunological and clinical effect of treating mice bearing premalignant oral lesions with a TGF-β type 1 receptor inhibitor plus IL-23 as an approach to sustain the Th17 phenotype. These studies showed that the treatment approach not only sustained the Th17 phenotype, but also increased distal spleen cell and regional lymph node cell production of other stimulatory/inflammatory mediators and slowed premalignant lesion progression to cancer. PMID:26756968

  11. Male-Biased Predation and Its Effect on Paternity Skew and Life History in a Population of Common Brushtail Possums (Trichosurus vulpecula)

    PubMed Central

    DeGabriel, Jane L.; Moore, Ben D.; Foley, William J.; Johnson, Christopher N.

    2014-01-01

    Differences in predation risk may exert strong selective pressures on life history strategies of populations. We investigated the potential for predation to shape male mating strategies in an arboreal folivore, the common brushtail possum (Trichosurus vulpecula Kerr). We predicted that possums in a tropical population exposed to high natural levels of predation would grow faster and reproduce earlier compared to those in temperate populations with lower predation. We trapped a population of possums in eucalypt woodland in northern Australia each month to measure life history traits and used microsatellites to genotype all individuals and assign paternity to all offspring. We observed very high levels of male-biased predation, with almost 60% of marked male possums being eaten by pythons, presumably as a result of their greater mobility due to mate-searching. Male reproductive success was also highly skewed, with younger, larger males fathering significantly more offspring. This result contrasts with previous studies of temperate populations experiencing low levels of predation, where older males were larger and the most reproductively successful. Our results suggest that in populations exposed to high levels of predation, male possums invest in increased growth earlier in life, in order to maximise their mating potential. This strategy is feasible because predation limits competition from older males and means that delaying reproduction carries a risk of failing to reproduce at all. Our results show that life histories are variable traits that can match regional predation environments in mammal species with widespread distributions. PMID:25372294

  12. Male-biased predation and its effect on paternity skew and life history in a population of common brushtail possums (Trichosurus vulpecula).

    PubMed

    DeGabriel, Jane L; Moore, Ben D; Foley, William J; Johnson, Christopher N

    2014-01-01

    Differences in predation risk may exert strong selective pressures on life history strategies of populations. We investigated the potential for predation to shape male mating strategies in an arboreal folivore, the common brushtail possum (Trichosurus vulpecula Kerr). We predicted that possums in a tropical population exposed to high natural levels of predation would grow faster and reproduce earlier compared to those in temperate populations with lower predation. We trapped a population of possums in eucalypt woodland in northern Australia each month to measure life history traits and used microsatellites to genotype all individuals and assign paternity to all offspring. We observed very high levels of male-biased predation, with almost 60% of marked male possums being eaten by pythons, presumably as a result of their greater mobility due to mate-searching. Male reproductive success was also highly skewed, with younger, larger males fathering significantly more offspring. This result contrasts with previous studies of temperate populations experiencing low levels of predation, where older males were larger and the most reproductively successful. Our results suggest that in populations exposed to high levels of predation, male possums invest in increased growth earlier in life, in order to maximise their mating potential. This strategy is feasible because predation limits competition from older males and means that delaying reproduction carries a risk of failing to reproduce at all. Our results show that life histories are variable traits that can match regional predation environments in mammal species with widespread distributions. PMID:25372294

  13. Favorable outcomes of hydroxychloroquine in insulin resistance may be accomplished by adjustment of the endothelial dysfunction as well as the skewed balance of adipokines.

    PubMed

    Abdel-Hamid, Ahmed A M; Firgany, Alaa El-Din L

    2016-07-01

    Hydroxychloroquine (HCQ) has been demonstrated to reduce the risk to develop diabetes mellitus (DM). However no previous experimental study had investigated its effect on the structure of the endocrine pancreas, islets of Langerhans (IOL), in insulin resistance (IR). In addition, the mechanism by which HCQ can prevent DM is not well understood. In this study, we hypothesized that the possible favorable outcome of HCQ may be partly achieved by its molecular effect on the endothelial stress markers as well as on the imparied balance of the adipokines that usually accompanies IR. A total of 54 rats were divided equally into; control, high fat diet (HFD) and HFD+HCQ groups (received standard chow, HFD and HFD+HCQ respectively). After 12 weeks, samples from pancreas as well as visceral adipose tissue (VAT) were histologically studied for the consequent changes. In the HFD group, there were mild degenerative changes and expansion of the IOL accompanied with a significantly increased (p<0.05) β-cell area%, mass, proliferation and neogenesis as well as a significantly decreased (p<0.05) α-cell area% compared with the other groups. On combining HCQ with HFD, reversal of these changes along with correction of the impaired adipokines levels (leptin, adiponectin, resistin, visfatin and lipocalin-2) and significant decrease (p<0.05) of the vascular endothelial stress markers (sE-selectin, sICAM and sVICAM) were manifested compared with the HFD group. Therefore, HCQ favorable effects in IR may be attributed to relieving of the endothelial stress as well as normalization of the skewed balance of adipokines. PMID:27320898

  14. Lagrangian Stochastic Modelling of Dispersion in the Convective Boundary Layer with Skewed Turbulence Conditions and a Vertical Density Gradient: Formulation and Implementation in the FLEXPART Model

    NASA Astrophysics Data System (ADS)

    Cassiani, Massimo; Stohl, Andreas; Brioude, Jerome

    2015-03-01

    A correction for the vertical gradient of air density has been incorporated into a skewed probability density function formulation for turbulence in the convective boundary layer. The related drift term for Lagrangian stochastic dispersion modelling has been derived based on the well-mixed condition. Furthermore, the formulation has been extended to include unsteady turbulence statistics and the related additional component of the drift term obtained. These formulations are an extension of the drift formulation reported by Luhar et al. (Atmos Environ 30:1407-1418, 1996) following the well-mixed condition proposed by Thomson (J Fluid Mech 180:529-556, 1987). Comprehensive tests were carried out to validate the formulations including consistency between forward and backward simulations and preservation of a well-mixed state with unsteady conditions. The stationary state CBL drift term with density correction was incorporated into the FLEXPART and FLEXPART-WRF Lagrangian models, and included the use of an ad hoc transition function that modulates the third moment of the vertical velocity based on stability parameters. Due to the current implementation of the FLEXPART models, only a steady-state horizontally homogeneous drift term could be included. To avoid numerical instability, in the presence of non-stationary and horizontally inhomogeneous conditions, a re-initialization procedure for particle velocity was used. The criteria for re-initialization and resulting errors were assessed for the case of non-stationary conditions by comparing a reference numerical solution in simplified unsteady conditions, obtained using the non-stationary drift term, and a solution based on the steady drift with re-initialization. Two examples of "real-world" numerical simulations were performed under different convective conditions to demonstrate the effect of the vertical gradient in density on the particle dispersion in the CBL.

  15. Experimental studies of Quasi-Two-Dimensional and three-dimensional viscous interaction regions induced by skewed-shock and swept-shock boundary layer interactions

    NASA Astrophysics Data System (ADS)

    Holden, M. S.

    1984-07-01

    This report describes results from 3 experimental studies designed to examine the aerothermal characteristics of regions of three-dimensional shock wave/boundary layer interaction in high-speed flow over non-adiabatic surfaces. The objectives were: (1) to explore the basic mechanisms associated with 3D boundary layer separation in high-speed flows with special emphasis on the large heat transfer rates and gradients developed in the separation and reattachment regions of these flows; and (2) to obtain detailed sets of experimental measurements with which to extend the simple semi-empirical prediction methods to the hypersonic/cooled wall regime where no previous data existed. These studies were conducted at Mach 11 for Reynolds number of up to 40 million in Calspan's 96-Inch Shock Tunnel. In the first study we examined the effects of crossflow on the scale and properties of attached and separated region induced over a flat plate at the base of skewed/oblique shocks. Analysis of the detailed heat transfer and pressure measurements together with flow visualization demonstrated that, for sweep angles of up to 45 deg, crossflow had little effect on the size or characteristics of the interaction regions. In the second study the swept-shock was induced normal to the flat plate boundary layer by a shock generator mounted perpendicular to the flat plate. Our corner flow measurements demonstrated that, in highly-cooled hypersonic flows, the pressure rise to induce incipient separation is significantly larger than predicted by the semi-empirical methods.

  16. An Incorrect Index of Skewness.

    ERIC Educational Resources Information Center

    Pettibone, Timothy J.; Diamond, James J.

    Checking of parametric assumptions is an often ignored step in the inferential process. A misconception regarding symmetry (one aspect of "robustness") is prevalent: that in nonsymmetric distributions the mean and median are always non-coincidental. It is to this fallacious point that the discussion is directed. A generally accepted index of…

  17. The CD8 and CD4 T-Cell Response against Kaposi's Sarcoma-Associated Herpesvirus Is Skewed Towards Early and Late Lytic Antigens

    PubMed Central

    Robey, Rebecca C.; Lagos, Dimitrios; Gratrix, Fiona; Henderson, Stephen; Matthews, Nick C.; Vart, Richard J.; Bower, Mark; Boshoff, Chris; Gotch, Frances M.

    2009-01-01

    Kaposi's sarcoma-associated herpesvirus (KSHV) is causally related to Kaposi's sarcoma (KS), the most common malignancy in untreated individuals with HIV/AIDS. The adaptive T-cell immune response against KSHV has not been fully characterized. To achieve a better understanding of the antigenic repertoire of the CD8 and CD4 T-cell responses against KSHV, we constructed a library of lentiviral expression vectors each coding for one of 31 individual KSHV open reading frames (ORFs). We used these to transduce monocyte-derived dendritic cells (moDCs) isolated from 14 KSHV-seropositive (12 HIV-positive) and 7 KSHV-seronegative (4 HIV-positive) individuals. moDCs were transduced with up to 3 KSHV ORFs simultaneously (ORFs grouped according to their expression during the viral life cycle). Transduced moDCs naturally process the KSHV genes and present the resulting antigens in the context of MHC class I and II. Transduced moDCs were cultured with purified autologous T cells and the CD8 and CD4 T-cell proliferative responses to each KSHV ORF (or group) was assessed using a CFSE dye-based assay. Two pools of early lytic KSHV genes ([ORF8/ORF49/ORF61] and [ORF59/ORF65/K4.1]) were frequently-recognized targets of both CD8 and CD4 T cells from KSHV seropositive individuals. One pool of late lytic KSHV genes ([ORF28/ORF36/ORF37]) was a frequently-recognized CD8 target and another pool of late genes ([ORF33/K1/K8.1]) was a frequently-recognized CD4 target. We report that both the CD8 and CD4 T-cell responses against KSHV are skewed towards genes expressed in the early and late phases of the viral lytic cycle, and identify some previously unknown targets of these responses. This knowledge will be important to future immunological investigations into KSHV and may eventually lead to the development of better immunotherapies for KSHV-related diseases. PMID:19536280

  18. Pacific plate apparent polar wander between 67 Ma and 44 Ma determined from the analysis of the skewness of both vector and scalar magnetic anomalies due to seafloor spreading

    NASA Astrophysics Data System (ADS)

    Zheng, L.; Gordon, R. G.; Horner-Johnson, B. C.

    2011-12-01

    Pacific plate apparent polar wander between 67 Ma and 44 Ma determined from the analysis of the skewness of both vector and scalar magnetic anomalies due to seafloor spreading The apparent polar wander (APW) path for the Pacific plate is important to the study of Pacific plate motions and their relation to circum-Pacific tectonics. It can be used to discriminate between alternative plate motion circuits, determine the motion of Pacific hotspots relative to the paleomagnetic axis, and test the fixed hotspot hypothesis. The pioneering investigations of Jean Francheteau and his colleagues of Pacific plate APW through the analysis of magnetic anomalies over seamounts helped to demonstrate that the Pacific plate has had substantial northward motion relative to the spin axis since Cretaceous time. We also investigate the APW of the Pacific plate through analysis of magnetic anomalies. Instead of anomalies over seamounts, however, we investigate the skewness (asymmetry) of magnetic anomalies due to seafloor spreading. In prior work, skewness analysis of shipboard magnetic profiles has been used to determine Pacific paleomagnetic poles for chron 25r (57 Ma B.P.; Petronotis et al., 1994), chron 27r to 31n (62 to 69 Ma B.P.; Acton and Gordon, 1991) and chron 32n (72 Ma B.P.; Petronotis and Gordon, 1999). Recently, vector aeromagnetic data from low paleolatitudes, combined with shipboard profiles from low paleolatitudes, were used to determine a paleomagnetic pole with compact confidence limits for anomaly 12r (32 Ma B.P.; Horner-Johnson and Gordon, 2010). Here we use the low-paleolatitude shipboard- and vector aero-magnetic profiles to determine new paleomagnetic poles for the Pacific plate. A new feature of our analysis is a correction for the spreading-rate dependence of anomalous skewness (Koivisto et al. 2011). We estimate anomalous skewness as a function of spreading rate for each anomaly by creating many synthetic profiles using the model of Dyment and Arkani

  19. Tests of a Triangular Wing of Aspect Ratio 2 in the Ames 12-foot Pressure Wind Tunnel III : the Effectiveness and Hinge Moments of a Skewed Wing-tip Flap

    NASA Technical Reports Server (NTRS)

    Kolbe, Carl D; Tinling, Bruce E

    1948-01-01

    Results of wind-tunnel tests of a semispan model of a triangular wing of aspect ratio 2 with a skewed wing-tip flap are presented. Lift, drag, pitching-moment, and hinge-moment data are included for subsonic Mach numbers up to 0.95. The flap showed extremely high hinge moments and low effectiveness as a longitudinal control. Although less affected by compressibility, this flap is indicated to be inferior to a constant-chord flap when applied to this triangular wing.

  20. Skewed T cell receptor repertoire of Vδ1+ γδ T lymphocytes after human allogeneic haematopoietic stem cell transplantation and the potential role for Epstein–Barr virus-infected B cells in clonal restriction

    PubMed Central

    Fujishima, N; Hirokawa, M; Fujishima, M; Yamashita, J; Saitoh, H; Ichikawa, Y; Horiuchi, T; Kawabata, Y; Sawada, K-I

    2007-01-01

    The proliferation of Vδ1+ γδ T lymphocytes has been described in various infections including human immunodeficiency virus (HIV), cytomegalovirus (CMV) and malaria. However, the antigen specificity and functions of the human Vδ1+ T cells remain obscure. We sought to explore the biological role for this T cell subset by investigating the reconstitution of T cell receptor (TCR) repertoires of Vδ1+ γδ T lymphocytes after human allogeneic haematopoietic stem cell transplantation (HSCT). We observed skewed TCR repertoires of the Vδ1+ T cells in 27 of 44 post-transplant patients. Only one patient developed EBV-associated post-transplant lymphoproliferative disorder in the present patient cohort. The -WGI- amino acid motif was observed in CDR3 of clonally expanded Vδ1+ T cells in half the patients. A skew was also detected in certain healthy donors, and the Vδ1+ T cell clone derived from the donor mature T cell pool persisted in the recipient's blood even 10 years after transplant. This T cell clone expanded in vitro against stimulation with autologous EBV–lymphoblastoid cell lines (LCL), and the Vδ1+ T cell line expanded in vitro from the same patient showed cytotoxicity against autologous EBV–LCL. EBV-infected cells could also induce in vitro oligoclonal expansions of autologous Vδ1+ T cells from healthy EBV-seropositive individuals. These results suggest that human Vδ1+ T cells have a TCR repertoire against EBV-infected B cells and may play a role in protecting recipients of allogeneic HSCT from EBV-associated disease. PMID:17425654

  1. Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.

    PubMed

    Mackall, C L; Bare, C V; Granger, L A; Sharrow, S O; Titus, J A; Gress, R E

    1996-06-15

    Thymic regenerative capacity in humans decreases with age, suggesting that thymic-independent pathways of T cell regeneration may predominate during adulthood. Using a murine bone marrow transplantation model, we present evidence that thymic-independent T cell regeneration occurs primarily via expansion of peripheral T cells and is Ag driven since significant expansion of CD4+ or CD8+ transgenic (Tg+)/TCR-bearing cells occurs only in the presence of Ag specific for the TCR. Such expansion resulted in skewing of the regenerated repertoire with 40 to 65% of the regenerated CD4+ or CD8+ T cells expressing the Tg+/TCR in thymectomized hosts after bone marrow transplantation. In experiments in which nontransgenic population are used as T cell inocula, we noted decreased CD4 expansion when Class II MHC was blocked by mAb treatment in vivo, an CD8 expansion failed to occur in Class I MHC-deficient hosts providing evidence that T cell regeneration in thymic-deficient hosts largely occurs via TCR-MHC-mediated selection of peripheral T cell populations. This process results in a T cell repertoire comprised exclusively of T cells recently activated by the antigenic milieu of the host, with negligible numbers of residual "naive" cells bearing TCRs for Ags absent at the time of expansion. These findings have important implications for approached to enhance T cell regeneration in humans and provide evidence that vaccine strategies could skew the T cell repertoire toward a specific antigenic target if administered to thymic-deficient hosts during immune reconstitution. PMID:8648103

  2. Early Skewed Distribution of Total and HIV-Specific CD8+ T-Cell Memory Phenotypes during Primary HIV Infection Is Related to Reduced Antiviral Activity and Faster Disease Progression

    PubMed Central

    Ghiglione, Yanina; Falivene, Juliana; Ruiz, María Julia; Laufer, Natalia; Socías, María Eugenia; Cahn, Pedro; Giavedoni, Luis; Sued, Omar; Gherardi, María Magdalena; Salomón, Horacio; Turk, Gabriela

    2014-01-01

    The important role of the CD8+ T-cells on HIV control is well established. However, correlates of immune protection remain elusive. Although the importance of CD8+ T-cell specificity and functionality in virus control has been underscored, further unraveling the link between CD8+ T-cell differentiation and viral control is needed. Here, an immunophenotypic analysis (in terms of memory markers and Programmed cell death 1 (PD-1) expression) of the CD8+ T-cell subset found in primary HIV infection (PHI) was performed. The aim was to seek for associations with functional properties of the CD8+ T-cell subsets, viral control and subsequent disease progression. Also, results were compared with samples from Chronics and Elite Controllers. It was found that normal maturation of total and HIV-specific CD8+ T-cells into memory subsets is skewed in PHI, but not at the dramatic level observed in Chronics. Within the HIV-specific compartment, this alteration was evidenced by an accumulation of effector memory CD8+ T (TEM) cells over fully differentiated terminal effector CD8+ T (TTE) cells. Furthermore, higher proportions of total and HIV-specific CD8+ TEM cells and higher HIV-specific TEM/(TEM+TTE) ratio correlated with markers of faster progression. Analysis of PD-1 expression on total and HIV-specific CD8+ T-cells from PHI subjects revealed not only an association with disease progression but also with skewed memory CD8+ T-cell differentiation. Most notably, significant direct correlations were obtained between the functional capacity of CD8+ T-cells to inhibit viral replication in vitro with higher proportions of fully-differentiated HIV-specific CD8+ TTE cells, both at baseline and at 12 months post-infection. Thus, a relationship between preservation of CD8+ T-cell differentiation pathway and cell functionality was established. This report presents evidence concerning the link among CD8+ T-cell function, phenotype and virus control, hence supporting the instauration of

  3. Alum and Squalene-Oil-in-Water Emulsion Enhance the Titer and Avidity of Anti-Aβ Antibodies Induced by Multimeric Protein Antigen (1–11)E2, Preserving the Igg1-Skewed Isotype Distribution

    PubMed Central

    Mantile, Francesca; Trovato, Maria; Santoni, Andrea; Barba, Pasquale; Ottonello, Simone; De Berardinis, Piergiuseppe; Prisco, Antonella

    2014-01-01

    The development of active immunotherapy for Alzheimer's disease (AD) requires the identification of immunogens that can ensure a high titer antibody response toward Aβ, while minimizing the risks of adverse reactions. Multimeric protein (1–11)E2 induces a robust and persistent antibody response to Aβ in mice, when formulated in Freund's adjuvant. The goal of this translational study was to evaluate the immunogenicity of (1–11)E2 formulated in alum (Alhydrogel 2%), or in a squalene oil-in-water emulsion (AddaVax), or without adjuvant. A IgG1-skewed isotype distribution was observed for the anti-Aβ antibodies generated in mice immunized with either the non-adjuvanted or the adjuvanted vaccine, indicating that (1–11)E2 induces a Th2-like response in all tested conditions. Both Alhydrogel 2% and AddaVax enhanced the titer and avidity of the anti-Aβ response elicited by (1–11)E2. We conclude that (1–11)E2 is a promising candidate for anti-Aβ immunization protocols that include alum or squalene-oil-in-water emulsion, or no adjuvant. PMID:24983378

  4. Nicotine can skew the characterization of the macrophage type-1 (M{Phi}1) phenotype differentiated with granulocyte-macrophage colony-stimulating factor to the M{Phi}2 phenotype

    SciTech Connect

    Yanagita, Manabu; Kobayashi, Ryohei; Murakami, Shinya

    2009-10-09

    Macrophages (M{Phi}s) exhibit functional heterogeneity and plasticity in the local microenvironment. Recently, it was reported that M{Phi}s can be divided into proinflammatory M{Phi}s (M{Phi}1) and anti-inflammatory M{Phi}s (M{Phi}2) based on their polarized functional properties. Here, we report that nicotine, the major ingredient of cigarette smoke, can modulate the characteristics of M{Phi}1. Granulocyte-macrophage colony-stimulating factor-driven M{Phi}1 with nicotine (Ni-M{Phi}1) showed the phenotypic characteristics of M{Phi}2. Like M{Phi}2, Ni-M{Phi}1 exhibited antigen-uptake activities. Ni-M{Phi}1 suppressed IL-12, but maintained IL-10 and produced high amounts of MCP-1 upon lipopolysaccharide stimulation compared with M{Phi}1. Moreover, we observed strong proliferative responses of T cells to lipopolysaccharide-stimulated M{Phi}1, whereas Ni-M{Phi}1 reduced T cell proliferation and inhibited IFN-{gamma} production by T cells. These results suggest that nicotine can change the functional characteristics of M{Phi} and skew the M{Phi}1 phenotype to M{Phi}2. We propose that nicotine is a potent regulator that modulates immune responses in microenvironments.

  5. How Skewed Is "The Bell Curve"?

    ERIC Educational Resources Information Center

    Haynes, Norris M.

    Few books have generated as much controversy as the recently published "The Bell Curve: Intelligence and Class Structure in American Life." The tremendous polarization on the issue of the relationship between intelligence quotient (IQ) to race and social class, reinforced by the book, and the potential this book has for undermining social programs…

  6. Geometric Skewness in the Passive Tracer Problem

    NASA Astrophysics Data System (ADS)

    Aminian, Manuchehr; Bernardi, Francesca; Camassa, Roberto; McLaughlin, Richard

    2015-11-01

    The classic work by G.I. Taylor describes the enhanced longitudinal diffusivity of a passive tracer in laminar pipe flow. Much work since then has gone into extending this result particularly in calculating the evolution of the scalar variance. However, less work has been done to describe the asymmetry of the distribution. We present the results from a modeling effort for the general picture of how the higher moments of the tracer distribution depend on geometry. We do this via analysis of ``channel-limiting'' geometries (rectangular ducts and elliptical pipes parameterized by their aspect ratio), using both new analytical tools and Monte-Carlo simulation, which have revealed a wealth of nontrivial behavior of the distributions at short and intermediate time. Funding from NSF grant Nos.: RTG DMS-0943851, CMG ARC-1025523, and DMS-1009750.

  7. A Skew-Normal Mixture Regression Model

    ERIC Educational Resources Information Center

    Liu, Min; Lin, Tsung-I

    2014-01-01

    A challenge associated with traditional mixture regression models (MRMs), which rest on the assumption of normally distributed errors, is determining the number of unobserved groups. Specifically, even slight deviations from normality can lead to the detection of spurious classes. The current work aims to (a) examine how sensitive the commonly…

  8. Educational Attainment Skewed in California Community Colleges?

    ERIC Educational Resources Information Center

    Levin, John S.; Beach, Josh M.; Kisker, Carrie B.

    2009-01-01

    We address the emphasis of the California Community College system upon credentials in their effort to document student outcomes. Statewide curricular awards (associate degrees and certificates) were collected over a four-year period. Data were organized descriptively and analyzed in order to identify long term trends. These curricular trends are…

  9. Experimental Persistent Infection of BALB/c Mice with Small-Colony Variants of Burkholderia pseudomallei Leads to Concurrent Upregulation of PD-1 on T Cells and Skewed Th1 and Th17 Responses

    PubMed Central

    See, Jia-Xiang; Samudi, Chandramathi; Saeidi, Alireza; Menon, Nivedita; Choh, Leang-Chung; Vadivelu, Jamuna; Shankar, Esaki M.

    2016-01-01

    Background Burkholderia pseudomallei (B. pseudomallei), the causative agent of melioidosis, is a deadly pathogen endemic across parts of tropical South East Asia and Northern Australia. B. pseudomallei can remain latent within the intracellular compartment of the host cell over prolonged periods of time, and cause persistent disease leading to treatment difficulties. Understanding the immunological mechanisms behind persistent infection can result in improved treatment strategies in clinical melioidosis. Methods Ten-day LD50 was determined for the small-colony variant (SCV) and its parental wild-type (WT) via intranasal route in experimental BALB/c mice. Persistent B. pseudomallei infection was generated by administrating sub-lethal dose of the two strains based on previously determined LD50. After two months, peripheral blood mononuclear cells (PBMCs) and plasma were obtained to investigate host immune responses against persistent B. pseudomallei infection. Lungs, livers, and spleens were harvested and bacterial loads in these organs were determined. Results Based on the ten-day LD50, the SCV was ~20-fold less virulent than the WT. The SCV caused higher bacterial loads in spleens compared to its WT counterparts with persistent B. pseudomallei infection. We found that the CD4+ T-cell frequencies were decreased, and the expressions of PD-1, but not CTLA-4 were significantly increased on the CD4+ and CD8+ T cells of these mice. Notably, persistent infection with the SCV led to significantly higher levels of PD-1 than the WT B. pseudomallei. Plasma IFN-γ, IL-6, and IL-17A levels were elevated only in SCV-infected mice. In addition, skewed plasma Th1 and Th17 responses were observed in SCV-infected mice relative to WT-infected and uninfected mice. Conclusion B. pseudomallei appears to upregulate the expression of PD-1 on T cells to evade host immune responses, which likely facilitates bacterial persistence in the host. SCVs cause distinct pathology and immune

  10. Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells.

    PubMed

    Zhang, Jing; Li, Li; Baldwin, Albert S; Friedman, Alan D; Paz-Priel, Ido

    2015-01-01

    transcription factors, skewing differentiation towards myeloid over erythroid differentiation, increased progenitor self-renewal, and increased number of functional long term HSCs. These data inform ongoing efforts to develop IKK inhibitors for clinical use. PMID:26102347

  11. Unmasking Pseudoscience: Comments on "How Skewed Is 'The Bell Curve?'"

    ERIC Educational Resources Information Center

    Fairchild, Halford H.

    1995-01-01

    Agrees with Haynes' assessment of "The Bell Curve" as scientifically flawed research with adverse political implications and as pseudoscientifically representing racism. The author criticizes Haynes for not fully illuminating the dangerous implications (now occurring) for the well-being of blacks today and into the next century. (GR)

  12. Skewness for Maximum Likelihood Estimators of the Negative Binomial Distribution

    SciTech Connect

    Bowman, Kimiko o

    2007-01-01

    The probability generating function of one version of the negative binomial distribution being (p + 1 - pt){sup -k}, we study elements of the Hessian and in particular Fisher's discovery of a series form for the variance of k, the maximum likelihood estimator, and also for the determinant of the Hessian. There is a link with the Psi function and its derivatives. Basic algebra is excessively complicated and a Maple code implementation is an important task in the solution process. Low order maximum likelihood moments are given and also Fisher's examples relating to data associated with ticks on sheep. Efficiency of moment estimators is mentioned, including the concept of joint efficiency. In an Addendum we give an interesting formula for the difference of two Psi functions.

  13. The gestural misinformation effect: skewing eyewitness testimony through gesture.

    PubMed

    Gurney, Daniel J; Pine, Karen J; Wiseman, Richard

    2013-01-01

    The susceptibility of eyewitnesses to verbal suggestion has been well documented, although little attention has been paid to the role of nonverbal communication in misinformation. Three experiments are reported; in each, participants watched footage of a crime scene before being questioned about what they had observed. In Experiments 1 and 2, an on-screen interviewer accompanied identically worded questions with gestures that either conveyed accurate information about the scene or conveyed false, misleading information. The misleading gestures significantly influenced recall, and participants' responses were consistent with the gestured information. In Experiment 3, a live interview was conducted, and the gestural misinformation effect was found to be robust; participants were influenced by misleading gestures performed by the interviewer during questioning. These findings provide compelling evidence for the gestural misinformation effect, whereby subtle hand gestures can implant information and distort the testimony of eyewitnesses. The practical and legal implications of these findings are discussed. PMID:24027944

  14. Second quantisation for skew convolution products of infinitely divisible measures

    NASA Astrophysics Data System (ADS)

    Applebaum, David; van Neerven, Jan

    2015-03-01

    Suppose λ1 and λ2 are infinitely divisible Radon measures on real Banach spaces E1 and E2, respectively and let T : E1 → E2 be a Borel measurable mapping so that T(λ1) * ρ = λ2 for some Radon probability measure ρ on E2. Extending previous results for the Gaussian and the Poissonian case, we study the problem of representing the "transition operator" PT : Lp(E2, λ2) → Lp(E1, λ1) given by $PTf(x) = ∫ E{2}f(T(x) + y)dρ (y)$ as the second quantisation of a contraction operator acting between suitably chosen "reproducing kernel Hilbert spaces" associated with λ1 and λ2.

  15. Although Relatively Few, "Doctor Shoppers" Skew Opioid Prescribing

    MedlinePlus

    ... integrating prescription history data into patients’ electronic medical records. “These doctor-shopping patients are clearly different, and they are exploiting the absence of good data management right now. The best way to improve the ...

  16. Carcinoma origin dictates differential skewing of monocyte function

    PubMed Central

    Bögels, Marijn; Braster, Rens; Nijland, Philip G.; Gül, Nuray; van de Luijtgaarden, Wendy; Fijneman, Remond J.A.; Meijer, Gerrit A.; Jimenez, Connie R.; Beelen, Robert H.J.; van Egmond, Marjolein

    2012-01-01

    Macrophages are versatile cells, which phenotype is profoundly influenced by their environment. Pro-inflammatory classically activated or M1 macrophages, and anti-inflammatory alternatively-activated or M2 macrophages represent two extremes of a continuum of functional states. Consequently, macrophages that are present in tumors can exert tumor-promoting and tumor-suppressing activity, depending on the tumor milieu. In this study we investigated how human monocytes—the precursors of macrophages—are influenced by carcinoma cells of different origin. We demonstrate that monocytes, stimulated with breast cancer supernatant, showed increased expression of interleukin (IL)-10, IL-8 and chemokines CCL17 and CCL22, which are associated with an alternatively-activated phenotype. By contrast, monocytes that were cultured in supernatants of colon cancer cells produced more pro-inflammatory cytokines (e.g., IL-12 and TNFα) and reactive oxygen species. Secretome analysis revealed differential secretion of proteins by colon and breast cancer cell lines, of which the proteoglycan versican was exclusively secreted by colon carcinoma cell lines. Reducing active versican by blocking with monoclonal antibodies or shRNA diminished pro-inflammatory cytokine production by monocytes. Thus, colon carcinoma cells polarize monocytes toward a more classically-activated anti-tumorigenic phenotype, whereas breast carcinomas predispose monocytes toward an alternatively activated phenotype. Interestingly, presence of macrophages in breast or colon carcinomas correlates with poor or good prognosis in patients, respectively. The observed discrepancy in macrophage activation by either colon or breast carcinoma cells may therefore explain the dichotomy between patient prognosis and macrophage presence in these different tumors. Designing new therapies, directing development of monocytes toward M1 activated tumor macrophages in cancer patients, may have great clinical benefits. PMID:23162747

  17. Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications

    PubMed Central

    Togliatto, Gabriele; Dentelli, Patrizia; Brizzi, Maria Felice

    2015-01-01

    Vascular complications are major causes of morbidity and mortality in type 2 diabetes patients. Mitochondrial reactive oxygen species (ROS) generation and a lack of efficient antioxidant machinery, a result of hyperglycaemia, mainly contribute to this problem. Although advances in therapy have significantly reduced both morbidity and mortality in diabetic individuals, diabetes-associated vascular complications are still one of the most challenging health problems worldwide. New healing options are urgently needed as current therapeutics are failing to improve long-term outcomes. Particular effort has recently been devoted to understanding the functional relationship between chromatin structure regulation and the persistent change in gene expression which is driven by hyperglycaemia and which accounts for long-lasting diabetic complications. A detailed investigation into epigenetic chromatin modifications in type 2 diabetes is underway. This will be particularly useful in the design of mechanism-based therapeutics which interfere with long-lasting activating epigenetics and improve patient outcomes. We herein provide an overview of the most relevant mechanisms that account for hyperglycaemia-induced changes in chromatin structure; the most relevant mechanism is called “metabolic memory.” PMID:26064979

  18. Schroedinger uncertainty relation with Wigner-Yanase skew information

    SciTech Connect

    Furuichi, Shigeru

    2010-09-15

    We shall give an alternative Schroedinger-type uncertainty relation for a quantity representing a quantum uncertainty, introduced by Luo [Phys. Rev. A 72, 042110 (2005)]. Our result improves the Heisenberg-type uncertainty relation shown in Luo's paper for a mixed state.

  19. Extracellular HSP110 skews macrophage polarization in colorectal cancer.

    PubMed

    Berthenet, Kevin; Boudesco, Christophe; Collura, Ada; Svrcek, Magali; Richaud, Sarah; Hammann, Arlette; Causse, Sebastien; Yousfi, Nadhir; Wanherdrick, Kristell; Duplomb, Laurence; Duval, Alex; Garrido, Carmen; Jego, Gaetan

    2016-07-01

    HSP110 is induced by different stresses and, through its anti-apoptotic and chaperoning properties, helps the cells to survive these adverse situations. In colon cancers, HSP110 is abnormally abundant. We have recently showed that colorectal cancer (CRC) patients with microsatellite instability (MSI) had an improved response to chemotherapy because they harbor an HSP110 inactivating mutation (HSP110DE9). In this work, we have used patients' biopsies and human CRC cells grown in vitro and in vivo (xenografts) to demonstrate that (1) HSP110 is secreted by CRC cells and that the amount of this extracellular HSP110 is strongly decreased by the expression of the mutant HSP110DE9, (2) Supernatants from CRC cells overexpressing HSP110 or purified recombinant human HSP110 (LPS-free) affect macrophage differentiation/polarization by favoring a pro-tumor, anti-inflammatory profile, (3) Conversely, inhibition of HSP110 (expression of siRNA, HSP110DE9 or immunodepletion) induced the formation of macrophages with a cytotoxic, pro-inflammatory profile. (4) Finally, this effect of extracellular HSP110 on macrophages seems to implicate TLR4. These results together with the fact that colorectal tumor biopsies with HSP110 high were infiltrated with macrophages with a pro-tumoral profile while those with HSP110 low were infiltrated with macrophages with a cytotoxic profile, suggest that the effect of extracellular HSP110 function on macrophages may also contribute to the poor outcomes associated with HSP110 expression. PMID:27622020

  20. Skewed Sex Ratios and Criminal Victimization in India

    PubMed Central

    South, Scott J.; Trent, Katherine; Bose, Sunita

    2014-01-01

    Although substantial research has explored the causes of India’s excessively masculine population sex ratio, few studies have examined the consequences of this surplus of males. We merge individual-level data from the 2004–2005 India Human Development Survey with data from the 2001 India population census to examine the association between the district-level male-to-female sex ratio at ages 15 to 39 and self-reports of victimization by theft, breaking and entering, and assault. Multilevel logistic regression analyses reveal positive and statistically significant albeit substantively modest effects of the district-level sex ratio on all three victimization risks. We also find that higher male-to-female sex ratios are associated with the perception that young unmarried women in the local community are frequently harassed. Household-level indicators of family structure, socioeconomic status, and caste, as well as areal indicators of women’s empowerment and collective efficacy, also emerge as significant predictors of self-reported criminal victimization and the perceived harassment of young women. The implications of these findings for India’s growing sex ratio imbalance are discussed. PMID:24682921

  1. Evaluating the performance of skewed prestressed concrete bridge after strengthening

    NASA Astrophysics Data System (ADS)

    Naser, Ali; Zonglin, Wang

    2013-06-01

    The objectives of this paper are to explain the application of repairing and strengthening methods on the damaged members of the bridge structure, to analyze the static and dynamic structural response under static and dynamic loads after strengthening, and to evaluate the structural performance after application of strengthening method. The repairing and strengthening methods which are used in this study include treatment of the cracks, thickening the web of box girder along the bridge length and adding internal pre-stressing tendons in the thickening web, and construct reinforced concrete cross beams (diaphragms) between two box girders. The results of theoretical analysis of static and dynamic structural responses after strengthening show that the tensile stresses are decreased and become less than the allowable limit values in the codes. The values of vertical deflection are decreased after strengthening. The values of natural frequencies after strengthening are increased, indicating that the strengthening method is effective to reduce the vibration of the bridge structure. Therefore, the strengthening methods are effective to improve the bearing capacity and elastic working state of the bridge structure and to increase the service life of the bridge structure.

  2. Incubation temperature causes skewed sex ratios in a precocial bird.

    PubMed

    DuRant, Sarah E; Hopkins, William A; Carter, Amanda W; Kirkpatrick, Laila T; Navara, Kristin J; Hawley, Dana M

    2016-07-01

    Many animals with genetic sex determination are nonetheless capable of manipulating sex ratios via behavioral and physiological means, which can sometimes result in fitness benefits to the parent. Sex ratio manipulation in birds is not widely documented, and revealing the mechanisms for altered sex ratios in vertebrates remains a compelling area of research. Incubation temperature is a key component of the developmental environment for birds, but despite its well-documented effects on offspring phenotype it has rarely been considered as a factor in avian sex ratios. Using ecologically relevant manipulations of incubation temperature within the range 35.0-37.0°C, we found greater mortality of female embryos during incubation than males regardless of incubation temperature, and evidence that more female than male embryos die at the lowest incubation temperature (35.0°C). Our findings in conjunction with previous work in brush turkeys suggest incubation temperature is an important determinant of avian secondary sex ratios that requires additional study, and should be considered when estimating the impact of climate change on avian populations. PMID:27143750

  3. Write-Skewed: Writing in an Introductory Statistics Course

    ERIC Educational Resources Information Center

    Delcham, Hendrick; Sezer, Renan

    2010-01-01

    Statistics is used in almost every facet of our daily lives: crime reports, election results, environmental/climate change, advances in business, financial planning, and progress in multifarious research. Although understanding statistics is essential for efficient functioning in the modern world (Cerrito 1996), students often do not grasp…

  4. Mutual impedance of nonplanar-skew sinusoidal dipoles

    NASA Technical Reports Server (NTRS)

    Richmond, J. H.; Geary, N. H.

    1975-01-01

    The mutual impedance expressions for parallel dipoles in terms of sine-integrals and cosine-integrals have been published by King (1957). The investigation reported provides analogous expressions for nonparallel dipoles. The expressions presented are most useful when the monopoles are close together. The theory of moment methods shows an approach for employing the mutual impedance of filamentary sinusoidal dipoles to calculate the impedance and scattering properties of straight and bent wires with small but finite diameter.

  5. Fractal Weyl law for skew extensions of expanding maps

    NASA Astrophysics Data System (ADS)

    Jean-François, Arnoldi

    2012-06-01

    We consider compact Lie group extensions of expanding maps of the circle, essentially restricting to SU(2) extensions. The main objective of the paper is the associated Ruelle transfer (or pull-back) operator \\hat{\\msF} . Harmonic analysis yields a natural decomposition \\hat{\\msF}=\\oplus\\hat{F}_{j} , where j indexes irreducible representation spaces. Using semi-classical techniques we extend a previous result by Faure proving an asymptotic spectral gap for the family \\{\\hat{F}_{j}\\} when restricted to adapted spaces of distributions. Our main result is a fractal Weyl upper bound for the number of eigenvalues (the Ruelle resonances) of these operators out of some fixed disc centred on 0 in the complex plane.

  6. The Heteroscedastic Graded Response Model with a Skewed Latent Trait: Testing Statistical and Substantive Hypotheses Related to Skewed Item Category Functions

    ERIC Educational Resources Information Center

    Molenaar, Dylan; Dolan, Conor V.; de Boeck, Paul

    2012-01-01

    The Graded Response Model (GRM; Samejima, "Estimation of ability using a response pattern of graded scores," Psychometric Monograph No. 17, Richmond, VA: The Psychometric Society, 1969) can be derived by assuming a linear regression of a continuous variable, Z, on the trait, [theta], to underlie the ordinal item scores (Takane & de Leeuw in…

  7. Myeloid lineage skewing due to exacerbated NF-κB signaling facilitates osteopenia in Scurfy mice

    PubMed Central

    Chen, T H-P; Swarnkar, G; Mbalaviele, G; Abu-Amer, Y

    2015-01-01

    Immune surveillance through Foxp3+ regulatory T cells plays a crucial role in bone homeostasis. Scurfy, the mouse model of autoimmune IPEX syndrome, bears a loss-of-function mutation in Foxp3 that leads to multi-organ inflammation. Herein, we report that scurfy mice exhibit severe bone loss mediated by accelerated osteoclastogenesis. Mechanistically, Foxp3 deficiency results in the upregulation of NF-κB in T helper cells through the loss of repressive Foxp3/NEMO interaction, thereby unleashing NF-κB-mediated over-production of pro-osteoclastogenic cytokines. Flow cytometry analysis shows marked increase in lin-Sca-1+c-kit+ hematopoietic stem cells (LSK HSCs) and granulocyte/macrophage progenitors (GMPs) in bone marrow of scurfy mice with corresponding exacerbated osteoclastogenic potential, implying that osteoclast progenitors are affected at a very primitive stage in this disorder. Scurfy LSK HSCs exhibit greater sensitivity to M-CSF and contain abundant PU.1+ Sf LSK HSCs compared with WT. Accordingly, genetic or pharmacological inhibition of M-CSF or mTOR signaling, but not IL-17 signaling, attenuates osteoclastogenesis and osteopenia in scurfy. Thus, our study suggests that Foxp3 deficiency leads to osteopenia owing to dysregulated NF-κB activity and subsequent cytokine-mediated hyper-proliferation of myeloid precursors, and positions the NF-κB pathway as a potential target for therapeutic intervention for this disorder. PMID:25880090

  8. Secreted Factors from Colorectal and Prostate Cancer Cells Skew the Immune Response in Opposite Directions

    PubMed Central

    Lundholm, Marie; Hägglöf, Christina; Wikberg, Maria L.; Stattin, Pär; Egevad, Lars; Bergh, Anders; Wikström, Pernilla; Palmqvist, Richard; Edin, Sofia

    2015-01-01

    Macrophage infiltration has been associated with an improved prognosis in patients with colorectal cancer (CRC), but a poor prognosis in prostate cancer (PC) patients. In this study, the distribution and prognostic value of proinflammatory M1 macrophages (NOS2+) and immunosuppressive M2 macrophages (CD163+) was evaluated in a cohort of 234 PC patients. We found that macrophages infiltrating PC were mainly of an M2 type and correlated with a more aggressive tumor and poor patient prognosis. Furthermore, the M1/M2 ratio was significantly decreased in PC compared to CRC. Using in vitro cell culture experiments, we could show that factors secreted from CRC and PC cells induced macrophages of a proinflammatory or immunosuppressive phenotype, respectively. These macrophages differentially affected autologous T lymphocyte proliferation and activation. Consistent with this, CRC specimens were found to have higher degrees of infiltrating T-helper 1 cells and active cytotoxic T lymphocytes, while PC specimens displayed functionally inactive T cells. In conclusion, our results imply that tumour-secreted factors from cancers of different origin can drive macrophage differentiation in opposite directions and thereby regulate the organization of the anti-tumour immune response. Our findings suggest that reprogramming of macrophages could be an important tool in the development of new immunotherapeutic strategies. PMID:26503803

  9. Title I Weighted Grants Skewed Toward Largest Districts: Per Pupil Funding Varies Sharply by District Size

    ERIC Educational Resources Information Center

    Rural School and Community Trust, 2007

    2007-01-01

    Since 2002, some of the federal funds provided to local school districts under Title I of the Elementary and Secondary Education Act have been distributed through "weighted" grant formulas intended to better target funding to districts with the highest concentrations of poverty. These weighted grant formulas have produced some perverse effects:…

  10. Heat transfer in rotating serpentine passages with selected model orientation for smooth or skewed trip walls

    NASA Technical Reports Server (NTRS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    1993-01-01

    Experiments were conducted to determine the effects of model orientation as well as buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. Turbine blades have internal coolant passage surfaces at the leading and trailing edges of the airfoil with surfaces at angles which are as large as +/- 50 to 60 degrees to the axis of rotation. Most of the previously-presented, multiple-passage, rotating heat transfer experiments have focused on radial passages aligned with the axis of rotation. Results from serpentine passages with orientations 0 and 45 degrees to the axis of rotation which simulate the coolant passages for the mid chord and trailing edge regions of the rotating airfoil are compared. The experiments were conducted with rotation in both directions to simulate serpentine coolant passages with the rearward flow of coolant or with the forward flow of coolant. The experiments were conducted for passages with smooth surfaces and with 45 degree trips adjacent to airfoil surfaces for the radial portion of the serpentine passages. At a typical flow condition, the heat transfer on the leading surfaces for flow outward in the first passage with smooth walls was twice as much for the model at 45 degrees compared to the model at 0 degrees. However, the differences for the other passages and with trips were less. In addition, the effects of buoyancy and Coriolis forces on heat transfer in the rotating passage were decreased with the model at 45 degrees, compared to the results at 0 degrees. The heat transfer in the turn regions and immediately downstream of the turns in the second passage with flow inward and in the third passage with flow outward was also a function of model orientation with differences as large as 40 to 50 percent occurring between the model orientations with forward flow and rearward flow of coolant.

  11. Descriptive Statistics for Modern Test Score Distributions: Skewness, Kurtosis, Discreteness, and Ceiling Effects

    ERIC Educational Resources Information Center

    Ho, Andrew D.; Yu, Carol C.

    2015-01-01

    Many statistical analyses benefit from the assumption that unconditional or conditional distributions are continuous and normal. More than 50 years ago in this journal, Lord and Cook chronicled departures from normality in educational tests, and Micerri similarly showed that the normality assumption is met rarely in educational and psychological…

  12. Effects of Mass and Volume Fraction Skewness in Variable Density Mixing Processes

    NASA Astrophysics Data System (ADS)

    Wachtor, Adam J.; Bakosi, Jozsef; Ristorcelli, Raymond

    2015-11-01

    Among the parameters characterizing mixing by variable density turbulence of fluids involving density variations of a factor of 5 to 10 are the Atwood, Froude, Schmidt, and Reynolds numbers. There is evidence that the amount of each fluid present when the two pure fluids mix, as described by the probability density function of the mass or molar (volume) fraction, also strongly affects the mixing process. To investigate this phenomena, implicit large-eddy simulations (ILES) are performed for binary fluid mixtures in statistically homogenous environments under constant acceleration. These coarse grained simulations are used as data for theory validation and mix model development. ILES has been demonstrated to accurately capture the mixing behavior of a passive scalar field through stirring and advection by a turbulent velocity field. The present work advances that research and studies the extent to which an under-resolved active scalar drives the subsequent fluid motion and determines the nature of the mixing process. Effects of initial distributions of the mass and molar (volume) fraction probability density function on the resulting variable density turbulence and mixing are investigated and compared to direct numerical simulations from the Johns Hopkins Turbulence Database. Funded by the LANL LDRD-ER on ``Inserting Nonlinear N-Material Coupling PDF Information into Turbulent Mixing Models'' through exploratory research project number 20150498ER.

  13. Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype

    PubMed Central

    Cardilo-Reis, Larissa; Gruber, Sabrina; Schreier, Sabine M; Drechsler, Maik; Papac-Milicevic, Nikolina; Weber, Christian; Wagner, Oswald; Stangl, Herbert; Soehnlein, Oliver; Binder, Christoph J

    2012-01-01

    Atherosclerotic lesions are characterized by the accumulation of oxidized LDL (OxLDL) and the infiltration of macrophages and T cells. Cytokine expression in the microenvironment of evolving lesions can profoundly contribute to plaque development. While the pro-atherogenic effect of T helper (Th) 1 cytokines, such as IFN-γ, is well established, the role of Th2 cytokines is less clear. Therefore, we characterized the role of the Th2 cytokine interleukin (IL)-13 in murine atherosclerosis. Here, we report that IL-13 administration favourably modulated the morphology of already established atherosclerotic lesions by increasing lesional collagen content and reducing vascular cell adhesion molecule-1 (VCAM-1)-dependent monocyte recruitment, resulting in decreased plaque macrophage content. This was accompanied by the induction of alternatively activated (M2) macrophages, which exhibited increased clearance of OxLDL compared to IFN-γ-activated (M1) macrophages in vitro. Importantly, deficiency of IL-13 results in accelerated atherosclerosis in LDLR−/− mice without affecting plasma cholesterol levels. Thus, IL-13 protects from atherosclerosis and promotes a favourable plaque morphology, in part through the induction of alternatively activated macrophages. PMID:23027612

  14. An Ancestral Recombination Graph for Diploid Populations with Skewed Offspring Distribution

    PubMed Central

    Birkner, Matthias; Blath, Jochen; Eldon, Bjarki

    2013-01-01

    A large offspring-number diploid biparental multilocus population model of Moran type is our object of study. At each time step, a pair of diploid individuals drawn uniformly at random contributes offspring to the population. The number of offspring can be large relative to the total population size. Similar “heavily skewed” reproduction mechanisms have been recently considered by various authors (cf. e.g., Eldon and Wakeley 2006, 2008) and reviewed by Hedgecock and Pudovkin (2011). Each diploid parental individual contributes exactly one chromosome to each diploid offspring, and hence ancestral lineages can coalesce only when in distinct individuals. A separation-of-timescales phenomenon is thus observed. A result of Möhle (1998) is extended to obtain convergence of the ancestral process to an ancestral recombination graph necessarily admitting simultaneous multiple mergers of ancestral lineages. The usual ancestral recombination graph is obtained as a special case of our model when the parents contribute only one offspring to the population each time. Due to diploidy and large offspring numbers, novel effects appear. For example, the marginal genealogy at each locus admits simultaneous multiple mergers in up to four groups, and different loci remain substantially correlated even as the recombination rate grows large. Thus, genealogies for loci far apart on the same chromosome remain correlated. Correlation in coalescence times for two loci is derived and shown to be a function of the coalescence parameters of our model. Extending the observations by Eldon and Wakeley (2008), predictions of linkage disequilibrium are shown to be functions of the reproduction parameters of our model, in addition to the recombination rate. Correlations in ratios of coalescence times between loci can be high, even when the recombination rate is high and sample size is large, in large offspring-number populations, as suggested by simulations, hinting at how to distinguish between different population models. PMID:23150600

  15. Skewed distribution of hypothyroidism in the coastal communities of Newfoundland, Canada.

    PubMed

    Sarkar, Atanu; Knight, John C; Babichuk, Nicole A; Mulay, Shree

    2015-10-01

    Several studies published in the recent past have shown that rising levels of thyroid disrupting chemicals (TDCs) in the environment affect thyroid function in humans. These TDCs are the anthropogenic organic compounds that enter the human body mostly by ingestion and may trigger autoimmune thyroiditis, the most common cause of hypothyroidism. The studies also show the presence of high levels of TDCs in marine animals; therefore, consumption of contaminated seafood might trigger hypothyroidism. So far, there is no readily available population-based data, showing the regional distribution of hypothyroidism cases. We collected administrative data from the Newfoundland and Labrador Centre for Health Information on hospitalizations with hypothyroidism (from 1998 to 2012) in 41 coastal communities of Newfoundland and found that mean hypothyroidism rates of west and south coasts were significantly higher than in the east coast (1.8 and 1.9 times respectively). A one-way analysis of variance was used to test for regional differences in rates. A significant between-group difference in the rate of hypothyroidism was found (F2,38 = 8.309; p = 0.001). The St. Lawrence River, its estuary and the Gulf of St. Lawrence are heavily polluted with TDCs from industries, their effluents, and urbanization in the Great Lakes Watershed and along the river. Environment Canada has already identified this river along with the Great Lakes Watershed as one of the top TDCs polluted water sources in the country. The west and south coasts are in contact with the Gulf of St. Lawrence. Local marine products are a regular diet of the coastal communities of Newfoundland. Based on these available evidence, we hypothesize the role of TDCs in the rise of hypothyroidism on the western and southern coasts. However, further study will be needed to establish any association between abnormally high rates of hypothyroidism and exposure to TDCs. PMID:26142926

  16. Synthesis and Chiroptical Properties of a Ring-Fused BODIPY with a Skewed Chiral π Skeleton.

    PubMed

    Gobo, Yuki; Yamamura, Masaki; Nakamura, Takashi; Nabeshima, Tatsuya

    2016-06-01

    A twisted chiral boron-dipyrrin complex (BODIPY) was synthesized by oxidative annulation of the biphenyl units at the β positions. The chiral BODIPY has two asymmetric carbons in the large planar skeleton, which were generated upon the ring-fused reaction. Its π-elongated and twisted structure resulted in the Cotton effect in the red region (λmax = 614 nm, Δε = 60 M(-1)·cm(-1)) as well as the strong fluorescence (ΦF = 0.73) and circularly polarized luminescence (CPL). PMID:27214262

  17. Dynamics of Neutral and Selected Alleles When the Offspring Distribution Is Skewed

    PubMed Central

    Der, Ricky; Epstein, Charles; Plotkin, Joshua B.

    2012-01-01

    We analyze the dynamics of two alternative alleles in a simple model of a population that allows for large family sizes in the distribution of offspring number. This population model was first introduced by Eldon and Wakeley, who described the backward-time genealogical relationships among sampled individuals, assuming neutrality. We study the corresponding forward-time dynamics of allele frequencies, with or without selection. We derive a continuum approximation, analogous to Kimura’s diffusion approximation, and we describe three distinct regimes of behavior that correspond to distinct regimes in the coalescent processes of Eldon and Wakeley. We demonstrate that the effect of selection is strongly amplified in the Eldon–Wakeley model, compared to the Wright–Fisher model with the same variance effective population size. Remarkably, an advantageous allele can even be guaranteed to fix in the Eldon–Wakeley model, despite the presence of genetic drift. We compute the selection coefficient required for such behavior in populations of Pacific oysters, based on estimates of their family sizes. Our analysis underscores that populations with the same effective population size may nevertheless experience radically different forms of genetic drift, depending on the reproductive mechanism, with significant consequences for the resulting allele dynamics. PMID:22661323

  18. Heat transfer in rotating serpentine passages with selected model orientation for smooth or skewed trip walls

    NASA Astrophysics Data System (ADS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    1993-04-01

    Experiments were conducted to determine the effects of model orientation as well as buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. Turbine blades have internal coolant passage surfaces at the leading and trailing edges of the airfoil with surfaces at angles which are as large as +/- 50 to 60 degrees to the axis of rotation. Most of the previously-presented, multiple-passage, rotating heat transfer experiments have focused on radial passages aligned with the axis of rotation. Results from serpentine passages with orientations 0 and 45 degrees to the axis of rotation which simulate the coolant passages for the mid chord and trailing edge regions of the rotating airfoil are compared. The experiments were conducted with rotation in both directions to simulate serpentine coolant passages with the rearward flow of coolant or with the forward flow of coolant. The experiments were conducted for passages with smooth surfaces and with 45 degree trips adjacent to airfoil surfaces for the radial portion of the serpentine passages. At a typical flow condition, the heat transfer on the leading surfaces for flow outward in the first passage with smooth walls was twice as much for the model at 45 degrees compared to the model at 0 degrees. However, the differences for the other passages and with trips were less. In addition, the effects of buoyancy and Coriolis forces on heat transfer in the rotating passage were decreased with the model at 45 degrees, compared to the results at 0 degrees. The heat transfer in the turn regions and immediately downstream of the turns in the second passage with flow inward and in the third passage with flow outward was also a function of model orientation with differences as large as 40 to 50 percent occurring between the model orientations with forward flow and rearward flow of coolant.

  19. Depth profiling of ion implanted materials with skewed doping distributions using Fourier transform infrared spectroscopy

    NASA Astrophysics Data System (ADS)

    Katsidis, Charalambos C.

    2008-01-01

    The applicability of a general transfer-matrix method for optical analysis of multilayers reported earlier [Katsidis and Siapkas, Appl. Opt. 41, 3978 (2002)] is being extended so as to simulate asymmetric implantation doping profiles using distributions with four moments. The sensitivity of infrared reflectance spectra regarding the variation of the first four moments of a Pearson free carrier distribution is demonstrated. Experimental data of 1.5 MeV as well as 2.5 MeV As implantation into p-Si followed by annealing at 1100 °C are presented, suggesting the need to use two joined Pearson IV distribution segments in the simulation of annealed profiles. A twin peak observed in the 1.5 MeV case is confirmed by Rutherford backscattering analysis.

  20. Linkage Disequilibrium Under Skewed Offspring Distribution Among Individuals in a Population

    PubMed Central

    Eldon, Bjarki; Wakeley, John

    2008-01-01

    Correlations in coalescence times between two loci are derived under selectively neutral population models in which the offspring of an individual can number on the order of the population size. The correlations depend on the rates of recombination and random drift and are shown to be functions of the parameters controlling the size and frequency of these large reproduction events. Since a prediction of linkage disequilibrium can be written in terms of correlations in coalescence times, it follows that the prediction of linkage disequilibrium is a function not only of the rate of recombination but also of the reproduction parameters. Low linkage disequilibrium is predicted if the offspring of a single individual frequently replace almost the entire population. However, high linkage disequilibrium can be predicted if the offspring of a single individual replace an intermediate fraction of the population. In some cases the model reproduces the standard Wright–Fisher predictions. Contrary to common intuition, high linkage disequilibrium can be predicted despite frequent recombination, and low linkage disequilibrium under infrequent recombination. Simulations support the analytical results but show that the variance of linkage disequilibrium is very large. PMID:18245371

  1. Divorce and infidelity are associated with skewed adult sex ratios in birds.

    PubMed

    Liker, András; Freckleton, Robert P; Székely, Tamás

    2014-04-14

    Adult sex ratio (ASR) is a fundamental concept in population demography, and recent theory suggests that ASR plays a central role in social behavior, mating systems, and parental care. Unbalanced ASRs are predicted to influence pair-bond and mating behavior, since the rarer sex in the population has more potential partners to mate with than the more common sex. Here we use phylogenetic comparative analyses to test whether ASR is related to three major aspects of mating behavior: divorce, social polygamy, and pair-bond infidelity. ASR is strongly correlated with long-term pair bonds, since the divorce rate is higher in species with a female-biased sex ratio, indicating that mate change by pair members and/or breaking of pair bonds by unmated individuals is more frequent when females outnumber males. Short-term pair bonds are also associated with unbalanced ASRs: males are more commonly polygamous when females outnumber males, and conversely, females are more polygamous when males outnumber females. Furthermore, infidelity increases with male-biased ASR in socially monogamous birds, suggesting that male coercion and/or female willingness to cheat the partner are facilitated by male-biased ASR. Our results provide the first comprehensive support for the proposition that ASR influences multiple aspects of pair-bond and mating behavior in wild populations. PMID:24656831

  2. Shared prefetching to reduce execution skew in multi-threaded systems

    DOEpatents

    Eichenberger, Alexandre E; Gunnels, John A

    2013-07-16

    Mechanisms are provided for optimizing code to perform prefetching of data into a shared memory of a computing device that is shared by a plurality of threads that execute on the computing device. A memory stream of a portion of code that is shared by the plurality of threads is identified. A set of prefetch instructions is distributed across the plurality of threads. Prefetch instructions are inserted into the instruction sequences of the plurality of threads such that each instruction sequence has a separate sub-portion of the set of prefetch instructions, thereby generating optimized code. Executable code is generated based on the optimized code and stored in a storage device. The executable code, when executed, performs the prefetches associated with the distributed set of prefetch instructions in a shared manner across the plurality of threads.

  3. Carbon dioxide at an unpolluted site analysed with the smoothing kernel method and skewed distributions.

    PubMed

    Pérez, Isidro A; Sánchez, M Luisa; García, M Ángeles; Pardo, Nuria

    2013-07-01

    CO₂ concentrations recorded for two years using a Picarro G1301 analyser at a rural site were studied applying two procedures. Firstly, the smoothing kernel method, which to date has been used with one linear and another circular variable, was used with pairs of circular variables: wind direction, time of day, and time of year, providing that the daily cycle was the prevailing cyclical evolution and that the highest concentrations were justified by the influence of one nearby city source, which was only revealed by directional analysis. Secondly, histograms were obtained, and these revealed most observations to be located between 380 and 410 ppm, and that there was a sharp contrast during the year. Finally, histograms were fitted to 14 distributions, the best known using analytical procedures, and the remainder using numerical procedures. RMSE was used as the goodness of fit indicator to compare and select distributions. Most functions provided similar RMSE values. However, the best fits were obtained using numerical procedures due to their greater flexibility, the triangular distribution being the simplest function of this kind. This distribution allowed us to identify directions and months of noticeable CO₂ input (SSE and April-May, respectively) as well as the daily cycle of the distribution symmetry. Among the functions whose parameters were calculated using an analytical expression, Erlang distributions provided satisfactory fits for monthly analysis, and gamma for the rest. By contrast, the Rayleigh and Weibull distributions gave the worst RMSE values. PMID:23602977

  4. The effect of transverse shear in a cracked plate under skew-symmetric loading

    NASA Technical Reports Server (NTRS)

    Delale, F.; Erdogan, F.

    1979-01-01

    The problem of an elastic plate containing a through crack and subjected to twisting moments or transverse shear loads is considered. By using a bending theory which allows the satisfaction of the boundary conditions on the crack surface regarding the normal and the twisting moments and the transverse shear load separately, it is found that the resulting asymptotic stress field around the crack tip becomes identical to that given by the elasticity solutions of the plane strain and antiplane shear problems. The problem is solved for uniformly distributed or concentrated twisting moment or transverse shear load and the normalized Mode II and Mode III stress-intensity factors are tabulated. The results also include the effect of the Poisson's ratio and material orthotropy for specially orthotropic materials on the stress-intensity factors.

  5. Male dominance rarely skews the frequency distribution of Y chromosome haplotypes in human populations

    PubMed Central

    Lansing, J. Stephen; Watkins, Joseph C.; Hallmark, Brian; Cox, Murray P.; Karafet, Tatiana M.; Sudoyo, Herawati; Hammer, Michael F.

    2008-01-01

    A central tenet of evolutionary social science holds that behaviors, such as those associated with social dominance, produce fitness effects that are subject to cultural selection. However, evidence for such selection is inconclusive because it is based on short-term statistical associations between behavior and fertility. Here, we show that the evolutionary effects of dominance at the population level can be detected using noncoding regions of DNA. Highly variable polymorphisms on the nonrecombining portion of the Y chromosome can be used to trace lines of descent from a common male ancestor. Thus, it is possible to test for the persistence of differential fertility among patrilines. We examine haplotype distributions defined by 12 short tandem repeats in a sample of 1269 men from 41 Indonesian communities and test for departures from neutral mutation-drift equilibrium based on the Ewens sampling formula. Our tests reject the neutral model in only 5 communities. Analysis and simulations show that we have sufficient power to detect such departures under varying demographic conditions, including founder effects, bottlenecks, and migration, and at varying levels of social dominance. We conclude that patrilines seldom are dominant for more than a few generations, and thus traits or behaviors that are strictly paternally inherited are unlikely to be under strong cultural selection. PMID:18703660

  6. Dynamics of mean-variance-skewness of cumulative crop yield impact temporal yield variance

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Production risk associated with cropping systems influences farmers’ decisions to adopt a new management practice or a production system. Cumulative yield (CY), temporal yield variance (TYV) and coefficient of variation (CV) were used to assess the risk associated with adopting combinations of new m...

  7. Kinetic heating due to a skewed shock wave/turbulent boundary layer interaction

    NASA Astrophysics Data System (ADS)

    Degrez, G.

    1981-01-01

    A flat/finned plate arrangement test configuration with both a sharp and a blunt fin was studied. The plate was set at angles of incidence of 7,4, and 0 degrees relative to the wind tunnel axis providing three different Mach numbers for the undisturbed flow over the flat plate (5.00, 5.53, and 6.07). Experimental data were obtained for three different shock generator angles of incidence 5,10, and 15 degrees and for three Mach numbers. Very satisfactory pressure and heat distributions were predicted by Schuderi's method. The blunting of the fin's heading edge resulted is an outward displacement of the pressure and heat transfer distribution caused by the outward displacement of the inviscid shock wave. The peak pressure was considerably reduced and the peak pressure and peak heating positions coincided.

  8. Skewed by Cues? The Motivational Role of Audiovisual Stimuli in Modelling Substance Use and Gambling Disorders.

    PubMed

    Barrus, Michael M; Cherkasova, Mariya; Winstanley, Catharine A

    2016-01-01

    The similarity between gambling disorder (GD) and drug addiction has recently been recognized at the diagnostic level. Understanding the core cognitive processes involved in these addiction disorders, and in turn their neurobiological mechanisms, remains a research priority due to the enormous benefits such knowledge would have in enabling effective treatment design. Animal models can be highly informative in this regard. Although numerous rodent behavioural paradigms that capture different facets of gambling-like behaviour have recently been developed, the motivational power of cues in biasing individuals towards risky choice has so far received little attention despite the central role played by drug-paired cues in successful laboratory models of chemical dependency. Here, we review some of the comparatively simple paradigms in which reward-paired cues are known to modulate behaviour in rodents, such as sign-tracking, Pavlovian-to-instrumental transfer and conditioned reinforcement. Such processes are thought to play an important role in mediating responding for drug reward, and the need for future studies to address whether similar processes contribute to cue-driven risky choice is highlighted. PMID:26531068

  9. Confidence Intervals for True Scores Using the Skew-Normal Distribution

    ERIC Educational Resources Information Center

    Garcia-Perez, Miguel A.

    2010-01-01

    A recent comparative analysis of alternative interval estimation approaches and procedures has shown that confidence intervals (CIs) for true raw scores determined with the Score method--which uses the normal approximation to the binomial distribution--have actual coverage probabilities that are closest to their nominal level. It has also recently…

  10. Stack zooming for multifocus interaction in skewed-aspect visual spaces.

    PubMed

    Javed, Waqas; Elmqvist, Niklas

    2013-08-01

    Many 2D visual spaces have a virtually one-dimensional nature with very high aspect ratio between the dimensions: examples include time-series data, multimedia data such as sound or video, text documents, and bipartite graphs. Common among these is that the space can become very large, e.g., temperature measurements could span a long time period, surveillance video could cover entire days or weeks, and documents can have thousands of pages. Many analysis tasks for such spaces require several foci while retaining context and distance awareness. In this extended version of our IEEE PacificVis 2010 paper, we introduce a method for supporting this kind of multifocus interaction that we call stack zooming. The approach is based on building hierarchies of 1D strips stacked on top of each other, where each subsequent stack represents a higher zoom level, and sibling strips represent branches in the exploration. Correlation graphics show the relation between stacks and strips of different levels, providing context and distance awareness for the foci. The zoom hierarchies can also be used as graphical histories and for communicating insights to stakeholders and can be further extended with annotation and integrated statistics. PMID:23744266

  11. Anti‐Inflammatory Immune Skewing Is Atheroprotective: Apoe−/−FcγRIIb−/− Mice Develop Fibrous Carotid Plaques

    PubMed Central

    Harmon, Erin Y.; Fronhofer, Van; Keller, Rebecca S.; Feustel, Paul J.; Zhu, Xinmei; Xu, Hao; Avram, Dorina; Jones, David M.; Nagarajan, Shanmugam; Lennartz, Michelle R.

    2014-01-01

    Background Stroke, caused by carotid plaque rupture, is a major cause of death in the United States. Whereas vulnerable human plaques have higher Fc receptor (FcγR) expression than their stable counterparts, how FcγR expression impacts plaque histology is unknown. We investigated the role of FcγRIIb in carotid plaque development and stability in apolipoprotein (Apo)e−/− and Apoe−/−FcγRIIb−/− double knockout (DKO) animals. Methods and Results Plaques were induced by implantation of a shear stress‐modifying cast around the carotid artery. Plaque length and stenosis were followed longitudinally using ultrasound biomicroscopy. Immune status was determined by flow cytometry, cytokine release, immunoglobulin G concentration and analysis of macrophage polarization both in plaques and in vitro. Surprisingly, DKO animals had lower plaque burden in both carotid artery and descending aorta. Plaques from Apoe−/− mice were foam‐cell rich and resembled vulnerable human specimens, whereas those from DKO mice were fibrous and histologically stable. Plaques from DKO animals expressed higher arginase 1 (Arg‐1) and lower inducible nitric oxide synthase (iNOS), indicating the presence of M2 macrophages. Analysis of blood and cervical lymph nodes revealed higher interleukin (IL)‐10, immune complexes, and regulatory T cells (Tregs) and lower IL‐12, IL‐1β, and tumor necrosis factor alpha (TNF‐α) in DKO mice. Similarly, in vitro stimulation produced higher IL‐10 and Arg‐1 and lower iNOS, IL‐1β, and TNF‐α in DKO versus Apoe−/− macrophages. These results define a systemic anti‐inflammatory phenotype. Conclusions We hypothesized that removal of FcγRIIb would exacerbate atherosclerosis and generate unstable plaques. However, we found that deletion of FcγRIIb on a congenic C57BL/6 background induces an anti‐inflammatory Treg/M2 polarization that is atheroprotective. PMID:25516435

  12. Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers

    PubMed Central

    Mauri, Giorgio; Jachetti, Elena; Comuzzi, Barbara; Dugo, Matteo; Arioli, Ivano; Miotti, Silvia; Sangaletti, Sabina; Di Carlo, Emma; Tripodo, Claudio; Colombo, Mario P.

    2016-01-01

    Osteopontin (OPN) is a secreted glycoprotein, that belongs to the non-structural extracellular matrix (ECM), and its over expression in human prostate cancer has been associated with disease progression, androgen independence and metastatic ability. Nevertheless, the pathophysiology of OPN in prostate tumorigenesis has never been studied. We crossed TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice with OPN deficient (OPN−/−) mice and followed tumor onset and progression in these double mutants. Ultrasound examination detected the early onset of a rapidly growing, homogeneous and spherical tumor in about 60% of OPN−/− TRAMP mice. Such neoplasms seldom occurred in parental TRAMP mice otherwise prone to adenocarcinomas and were characterized for being androgen receptor negative, highly proliferative and endowed with neuroendocrine (NE) features. Gene expression profiling showed up-regulation of genes involved in tumor progression, cell cycle and neuronal differentiation in OPN-deficient versus wild type TRAMP tumors. Down-regulated genes included key genes of TGFa pathway, including SMAD3 and Filamin, which were confirmed at the protein level. Furthermore, NE genes and particularly those characterizing early prostatic lesions of OPN-deficient mice were found to correlate with those of human prostate NE tumours. These data underscore a novel role of OPN in the early stages of prostate cancer growth, protecting against the development of aggressive NE tumors. PMID:26700622

  13. Administration of estradiol benzoate before insemination could skew secondary sex ratio toward males in Holstein dairy cows.

    PubMed

    Emadi, S R; Rezaei, A; Bolourchi, M; Hovareshti, P; Akbarinejad, V

    2014-07-01

    The present study was conducted to investigate the effect of estradiol benzoate administration before insemination on secondary sex ratio (proportion of male calves at birth) in Holstein dairy cows. Cows (n = 1,647) were randomly assigned to 2 experimental groups by parity over a 1-yr period. Cows in the control group (n = 827; 232 primiparous and 595 multiparous cows) received 2 administrations of PGF2α (500 μg) 14 d apart, started at 30 to 35 d postpartum. Twelve d after the second PGF2α injection, cows received GnRH (100 μg), followed by administration of PGF2α 7 d later. Cows in the treatment group (n = 820; 238 primiparous and 582 multiparous cows) received the same hormonal administrations as the cows in the control group. Additionally, cows in the treatment group received estradiol benzoate (1 mg) 1 d after the third PGF2α injection. Estrus detection by visual observation was started 1 d after the third PGF2α injection and after estradiol administration in the control (for 6 d) and treatment (for 36 h) groups, respectively. Artificial insemination was carried out 12 h after observation of standing estrus. Exposure of cows to heat stress at conception was determined based on temperature-humidity index. Estrus detection rate was lower in primiparous than in multiparous cows (P < 0.05), but conception rate was higher in primiparous vs multiparous cows (P < 0.05). Estradiol administration improved estrus detection rate and fertility (P < 0.05); moreover, it increased secondary sex ratio (adjusted odds ratio: 1.645; P = 0.017). Exposure to heat stress diminished heat detection rate and fertility (P < 0.05), and altered secondary sex ratio toward males (adjusted odds ratio: 2.863; P = 0.012). In conclusion, the present study revealed that estradiol administration before insemination could improve fertility and increase the probability of calves being male in Holstein dairy cows. Moreover, the results showed that cows exposed to heat stress around conception had diminished fertility and increased secondary sex ratio. PMID:24906936

  14. Monocyte Subpopulations from Pre-Eclamptic Patients Are Abnormally Skewed and Exhibit Exaggerated Responses to Toll-Like Receptor Ligands

    PubMed Central

    Al-ofi, Ebtisam

    2012-01-01

    The leading cause of pregnancy-associated mortality and morbidity is pre-eclampsia (PE). Although information regarding the etiology of this disease is scant, its pathophysiology is characterized by abnormal placentation, endothelial dysfunction as well as an exaggerated inflammatory response. Clinical evidence also indicates that the abundance of many immune cells at the feto-maternal interface and in the circulation of PE patients is abnormal, when compared with normal pregnant (NP) controls. In addition, the phenotype and function of some of these cells is altered. To further characterize the systemic effects of PE on circulating cells, we analyzed monocytic subpopulations in NP and PE patients by flow cytometry. We found that non-classical CD14lowCD16+ monocytes are significantly increased in women with PE and they display irregular expression of several chemokine receptors and antigen presentation molecules. The most striking phenotypic difference among the cell surface molecules was the marked upregulation of TLR4 expression, where both CD14highCD16+ and CD14lowCD16+ monocytes demonstrated higher levels than their NP counterparts. Stimulation of PE monocytes with TLR ligands resulted in profound secretion of various cytokines in comparison with NP controls. These data suggest that PE monocytes are hyper-responsive to TLR ligands and this may contribute to exacerbation of the disease. PMID:22848746

  15. Monocyte subpopulations from pre-eclamptic patients are abnormally skewed and exhibit exaggerated responses to Toll-like receptor ligands.

    PubMed

    Al-ofi, Ebtisam; Coffelt, Seth B; Anumba, Dilly O

    2012-01-01

    The leading cause of pregnancy-associated mortality and morbidity is pre-eclampsia (PE). Although information regarding the etiology of this disease is scant, its pathophysiology is characterized by abnormal placentation, endothelial dysfunction as well as an exaggerated inflammatory response. Clinical evidence also indicates that the abundance of many immune cells at the feto-maternal interface and in the circulation of PE patients is abnormal, when compared with normal pregnant (NP) controls. In addition, the phenotype and function of some of these cells is altered. To further characterize the systemic effects of PE on circulating cells, we analyzed monocytic subpopulations in NP and PE patients by flow cytometry. We found that non-classical CD14(low)CD16(+) monocytes are significantly increased in women with PE and they display irregular expression of several chemokine receptors and antigen presentation molecules. The most striking phenotypic difference among the cell surface molecules was the marked upregulation of TLR4 expression, where both CD14(high)CD16(+) and CD14(low)CD16(+) monocytes demonstrated higher levels than their NP counterparts. Stimulation of PE monocytes with TLR ligands resulted in profound secretion of various cytokines in comparison with NP controls. These data suggest that PE monocytes are hyper-responsive to TLR ligands and this may contribute to exacerbation of the disease. PMID:22848746

  16. Bovine Immune Response to Papillomatous Digital Dermatitis (PDD)-associated Spirochetes is Skewed in Isolate Reactivity and Subclass Elicitation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Papillomatous digital dermatitis (PDD), also known as hairy heel wart, is a growing cause of lameness of cows in the U.S. dairy industry. Farms with PDD-afflicted cows experience economic loss due to treatment costs, decreased milk production, lower reproductive efficiency and premature culling. Cow...

  17. Bovine Immune Response to Papillomatous Digital Dermatitis (PDD)-Associated Spirochetes are Skewed in Isolate Reactivity and Subclass Elicitation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Background: Papillomatous digital dermatitis (PDD), also known as hairy heel wart, is a growing cause of lameness of cows in the U.S. dairy industry. Previous work using lesion material from a dairy farm in Iowa resulted in the isolation of four different Treponema phagedenis-like spirochetes (1A, 3...

  18. Mouse cytokine profile skewed towards Th2 in pregnancy during infection with Brucella abortus S19 strain.

    PubMed

    Wamonje, Francis O; Waihenya, Rebecca K; Ng'ang'a, Zipporah; Ngeranwa, Joseph N

    2011-04-01

    The two classes of cytokines Th1 and Th2 determine the type of immune response elicited. The Th2 immune response is associated with successful pregnancy. Brucellosis is an intracellular bacterium that elicits the Th1 response and is known to cause spontaneous abortion in mammalian species. This study sought to determine if Brucella infection causes spontaneous abortion by causing the circulating cytokine profile be Th1 dominant during pregnancy. Forty-eight Swiss white mice were used in this murine model and the S19 strain of Brucella abortus was used in as the infective agent. Pregnant mice in the test group were injected intraperitoneally with 10(5-8) CFU of Brucella and cytokine profile evaluated over the three trimesters of pregnancy. Pregnant mice in the control group were left to go through normal pregnancy and their cytokine profile evaluated over the three trimesters of pregnancy. Cytokines in serum samples were analyzed by Cytometric Bead Array. The data was analyzed using the Paired T- test and p < 0.05 was considered significant. IFN-γ and TNF-α represented the Th1 cytokines while IL-4 and IL-5 represented the Th2 cytokines. None of the mice in the test group had spontaneous abortion. IFN-γ and TNF-α had no significant differences between cytokine levels for infected and uninfected groups in all 3 trimesters of pregnancy. IL-4 levels had significant differences in all three trimesters of pregnancy (t = 13, P = 0.036, 0.0071 and 0.0277). IL-5 levels had significant differences second trimester (t = 14, P = 0.0075). The cytokine profile was robustly Th2. In conclusion, Brucella abortus cannot cause spontaneous abortion by altering the mouse cytokine profile towards Th1 in pregnancy. Elevated IL-4 levels with corresponding suppression of IFN-γ can be used as a marker for successful pregnancy in Brucellosis. PMID:25566611

  19. Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization

    PubMed Central

    Yang, Meixiang; Liu, Yanguo; Ren, Guangwen; Shao, Qianqian; Gao, Wenjuan; Sun, Jintang; Wang, Huayang; Ji, Chunyan; Li, Xingang; Zhang, Yun; Qu, Xun

    2015-01-01

    A low partial oxygen pressure (hypoxia) occurs in many pathological environments, such as solid tumors and inflammatory lesions. Understanding the cellular response to hypoxic stress has broad implications for human diseases. As we previously reported, hypoxia significantly altered dendritic cells (DCs) to a DC2 phenotype and promoted a Th2 polarization of naïve T cells with increased IL-4 production. However, the underlying mechanisms still remain largely unknown. In this study, we found the over-expression of surface CD44 in DCs was involved in this process via ligand binding. Further investigation showed hypoxia could reduce the surface expression of membrane type 1 metalloprotease (MT1-MMP) via down-regulating the kinesin-like protein KIF2A, which subsequently alleviated the shedding of CD44 from DCs. Moreover, KIF2A expression was found negatively regulated by HIF-1α in hypoxic microenvironment. These results suggest a previously uncharacterized mechanism by which hypoxia regulates the function of DCs via KIF2A/MT1-MMP/CD44 axis, providing critical information to understand the immune response under hypoxia. PMID:26323509

  20. Hematopoietic LTβR deficiency results in skewed T cell cytokine profiles during a mucosal viral infection.

    PubMed

    Sun, Tian; Rojas, Olga L; Li, Conglei; Philpott, Dana J; Gommerman, Jennifer L

    2016-07-01

    The lymphotoxin signaling pathway plays an important role in the homeostasis and function of peripheral and mucosal dendritic cells, and dendritic cell-intrinsic lymphotoxin β receptor expression is required for optimal responses to opportunistic intestinal bacteria. However, it is unknown whether dendritic cell-intrinsic lymphotoxin β receptor signaling is required for responses to intestinal viral infections. We explored this question by orally administrating murine rotavirus to chimeric mice that lack lymphotoxin β receptor signaling in the myeloid compartment but retain lymphoid tissues. We found that although clearance of rotavirus was unimpaired in the lymphotoxin β receptor(-/-) → wild-type chimeric mice compared with wild-type → wild-type chimeric mice, IFN-γ-producing CD8(+) and CD4(+) T cells were significantly increased in the small intestinal lamina propria of lymphotoxin β receptor(-/-) → wild-type chimeric mice. In contrast, IL-17-producing CD4(+) T cells were reduced in lymphotoxin β receptor(-/-) → wild-type chimeric mice in the steady state, and this reduction persisted after rotavirus inoculation. In spite of this altered cytokine profile in the small intestinal lamina propria of lymphotoxin β receptor(-/-) → wild-type chimeric mice, the local production of rotavirus-specific IgA was unperturbed. Collectively, our results demonstrate that lymphotoxin β receptor signaling in radio-sensitive myeloid cells regulates the balance of IFN-γ and IL-17 cytokine production within the small intestinal lamina propria; however, these perturbations do not affect mucosal antiviral IgA responses. PMID:26657790

  1. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

    PubMed Central

    Abdollahi-Roodsaz, Shahla; Joosten, Leo A.B.; Koenders, Marije I.; Devesa, Isabel; Roelofs, Mieke F.; Radstake, Timothy R.D.J.; Heuvelmans-Jacobs, Marleen; Akira, Shizuo; Nicklin, Martin J.H.; Ribeiro-Dias, Fátima; van den Berg, Wim B.

    2007-01-01

    TLRs may contribute to the progression of rheumatoid arthritis through recognition of microbial or host-derived ligands found in arthritic joints. Here, we show that TLR2 and TLR4, but not TLR9, are involved in the pathogenesis of autoimmune arthritis and play distinct roles in the regulation of T cells and cytokines. We investigated the involvement of TLR2, TLR4, and TLR9 in the progression of arthritis using IL-1 receptor antagonist–knockout (IL1rn–/–) mice, which spontaneously develop an autoimmune T cell–mediated arthritis. Spontaneous onset of arthritis was dependent on TLR activation by microbial flora, as germ-free mice did not develop arthritis. Clinical and histopathological evaluation of IL1rn–/–Tlr2–/– mice revealed more severe arthritis, characterized by reduced suppressive function of Tregs and substantially increased IFN-γ production by T cells. IL1rn–/–Tlr4–/– mice were, in contrast, protected against severe arthritis and had markedly lower numbers of Th17 cells and a reduced capacity to produce IL-17. A lack of Tlr9 did not affect the progression of arthritis. While any therapeutic intervention targeting TLR2 still seems complicated, the strict position of TLR4 upstream of a number of pathogenic cytokines including IL-17 provides an interesting potential therapeutic target for rheumatoid arthritis. PMID:18060042

  2. Reconstructing the Poynting vector skew angle and wavefront of optical vortex beams via two-channel moiré deflectometery.

    PubMed

    Yeganeh, Mohammad; Rasouli, Saifollah; Dashti, Mohsen; Slussarenko, Sergei; Santamato, Enrico; Karimi, Ebrahim

    2013-03-15

    An approach based on the two-channel moiré deflectometry has been used to measure both wavefront and transverse component of the Poynting vector of an optical vortex beam. Generated vortex beam by the q-plate, an inhomogeneous liquid crystal cell, has been analyzed with such technique. The measured topological charge of generated beams are in an excellent agreement with theoretical prediction. PMID:23503249

  3. Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers.

    PubMed

    Mauri, Giorgio; Jachetti, Elena; Comuzzi, Barbara; Dugo, Matteo; Arioli, Ivano; Miotti, Silvia; Sangaletti, Sabina; Di Carlo, Emma; Tripodo, Claudio; Colombo, Mario P

    2016-01-26

    Osteopontin (OPN) is a secreted glycoprotein, that belongs to the non-structural extracellular matrix (ECM), and its over expression in human prostate cancer has been associated with disease progression, androgen independence and metastatic ability. Nevertheless, the pathophysiology of OPN in prostate tumorigenesis has never been studied. We crossed TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice with OPN deficient (OPN-/-) mice and followed tumor onset and progression in these double mutants. Ultrasound examination detected the early onset of a rapidly growing, homogeneous and spherical tumor in about 60% of OPN-/- TRAMP mice. Such neoplasms seldom occurred in parental TRAMP mice otherwise prone to adenocarcinomas and were characterized for being androgen receptor negative, highly proliferative and endowed with neuroendocrine (NE) features. Gene expression profiling showed up-regulation of genes involved in tumor progression, cell cycle and neuronal differentiation in OPN-deficient versus wild type TRAMP tumors. Down-regulated genes included key genes of TGFa pathway, including SMAD3 and Filamin, which were confirmed at the protein level. Furthermore, NE genes and particularly those characterizing early prostatic lesions of OPN-deficient mice were found to correlate with those of human prostate NE tumours. These data underscore a novel role of OPN in the early stages of prostate cancer growth, protecting against the development of aggressive NE tumors. PMID:26700622

  4. Genetic Basis of Self-Incompatibility in the Lichen-Forming Fungus Lobaria pulmonaria and Skewed Frequency Distribution of Mating-Type Idiomorphs: Implications for Conservation

    PubMed Central

    Singh, Garima; Dal Grande, Francesco; Cornejo, Carolina; Schmitt, Imke; Scheidegger, Christoph

    2012-01-01

    Fungal populations that reproduce sexually are likely to be genetically more diverse and have a higher adaptive potential than asexually reproducing populations. Mating systems of fungal species can be self-incompatible, requiring the presence of isolates of different mating-type genes for sexual reproduction to occur, or self-compatible, requiring only one. Understanding the distribution of mating-type genes in populations can help to assess the potential of self-incompatible species to reproduce sexually. In the locally threatened epiphytic lichen-forming fungus Lobaria pulmonaria (L.) Hoffm., low frequency of sexual reproduction is likely to limit the potential of populations to adapt to changing environmental conditions. Our study provides direct evidence of self-incompatibility (heterothallism) in L. pulmonaria. It can thus be hypothesized that sexual reproduction in small populations might be limited by an unbalanced distribution of mating-type genes. We therefore assessed neutral genetic diversity (using microsatellites) and mating-type ratio in 27 lichen populations (933 individuals). We found significant differences in the frequency of the two mating types in 13 populations, indicating a lower likelihood of sexual reproduction in these populations. This suggests that conservation translocation activities aiming at maximizing genetic heterogeneity in threatened and declining populations should take into account not only presence of fruiting bodies in transplanted individuals, but also the identity and balanced representation of mating-type genes. PMID:23236495

  5. An exploratory approach demonstrating immune skewing and a loss of coordination among cytokines in plasma and saliva of Veterans with combat-related PTSD.

    PubMed

    Wang, Zhewu; Mandel, Howard; Levingston, Corinne A; Young, M Rita I

    2016-08-01

    Studies have suggested PTSD to be associated with an inflammatory state, although few studies have examined the balances between stimulatory and inhibitory immune mediators in PTSD. An exploratory approach was taken to assess the immune imbalances between Th1 stimulatory, inflammatory and inhibitory mediators associated with PTSD. This approach focused on a tightly-controlled and relatively homogeneous population of Veterans, all with similar levels of combat exposure in the Afghanistan and Iraq wars, but some testing negative and others testing positive for PTSD. Although the sample size was small (6 controls and 7 with PTSD) and a limitation of this study, the results showed significant imbalances in immune cytokines favoring a Th1 and inflammatory state, with reduced levels of inhibitory cytokines in Veterans with PTSD. This was particularly prominent in the saliva of PTSD subjects compared to in their plasma. PMID:27216157

  6. Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma.

    PubMed

    Krejcik, Jakub; Casneuf, Tineke; Nijhof, Inger S; Verbist, Bie; Bald, Jaime; Plesner, Torben; Syed, Khaja; Liu, Kevin; van de Donk, Niels W C J; Weiss, Brendan M; Ahmadi, Tahamtan; Lokhorst, Henk M; Mutis, Tuna; Sasser, A Kate

    2016-07-21

    Daratumumab targets CD38-expressing myeloma cells through a variety of immune-mediated mechanisms (complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and antibody-dependent cellular phagocytosis) and direct apoptosis with crosslinking. These mechanisms may also target nonplasma cells that express CD38, which prompted evaluation of daratumumab's effects on CD38-positive immune subpopulations. Peripheral blood (PB) and bone marrow (BM) from patients with relapsed/refractory myeloma from 2 daratumumab monotherapy studies were analyzed before and during therapy and at relapse. Regulatory B cells and myeloid-derived suppressor cells, previously shown to express CD38, were evaluated for immunosuppressive activity and daratumumab sensitivity in the myeloma setting. A novel subpopulation of regulatory T cells (Tregs) expressing CD38 was identified. These Tregs were more immunosuppressive in vitro than CD38-negative Tregs and were reduced in daratumumab-treated patients. In parallel, daratumumab induced robust increases in helper and cytotoxic T-cell absolute counts. In PB and BM, daratumumab induced significant increases in CD8(+):CD4(+) and CD8(+):Treg ratios, and increased memory T cells while decreasing naïve T cells. The majority of patients demonstrated these broad T-cell changes, although patients with a partial response or better showed greater maximum effector and helper T-cell increases, elevated antiviral and alloreactive functional responses, and significantly greater increases in T-cell clonality as measured by T-cell receptor (TCR) sequencing. Increased TCR clonality positively correlated with increased CD8(+) PB T-cell counts. Depletion of CD38(+) immunosuppressive cells, which is associated with an increase in T-helper cells, cytotoxic T cells, T-cell functional response, and TCR clonality, represents possible additional mechanisms of action for daratumumab and deserves further exploration. PMID:27222480

  7. Skewed T-cell receptor Vbeta8.2 expression in transgenic CD2-myc induced thymic lymphoma: a role for antigen stimulation in tumour development?

    PubMed Central

    Webster, G.; Onions, D. E.; Neil, J. C.; Cameron, E. R.

    1997-01-01

    Transgenic mice expressing the c-myc proto-oncogene under the control of the CD2-dominant control region show stochastic development of mainly clonal thymic lymphoma with long latency, indicating that cooperative events are needed for the development of the fully malignant phenotype. Previous studies have suggested that T-cell receptor-associated signals can contribute to tumour development. We have therefore used this transgenic model of T-cell transformation to determine whether antigen-specific responses could constitute an epigenetic event in lymphomagenesis. The T-cell receptor (TcR) repertoires of lymphoma clones were analysed with a panel of monoclonal antibodies (Abs) recognizing TcR Vbeta chains. The Vbeta repertoire of tumour clones arising in these mice was non-random with overrepresentation of Vbeta8.2 TcR species. The majority of Vbeta8.2+ clones were of a mature CD3+ CD8 single-positive (SP) phenotype. The biased TcR usage, together with a mature cell phenotype is consistent with the hypothesis that TcR-mediated signals cooperate with activated myc during T-cell transformation. Images Figure 1 PMID:9310239

  8. 1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter.

    PubMed

    Schedel, Michaela; Jia, Yi; Michel, Sven; Takeda, Katsuyuki; Domenico, Joanne; Joetham, Anthony; Ning, Fangkun; Strand, Matthew; Han, Junyan; Wang, Meiqin; Lucas, Joseph J; Vogelberg, Christian; Kabesch, Michael; O'Connor, Brian P; Gelfand, Erwin W

    2016-01-01

    Effector CD8(+) T cells convert from IFN-γ(+) (Tc1) to IL-13(+) (Tc2) cells in the presence of IL-4. Underlying regulatory mechanisms are not fully defined. Here, we show that addition of 1,25D3, the active form of vitamin D3, during CD8(+) T-cell differentiation prevents IL-4-induced conversion to IL-13-producers. Transfer of 1,25D3-treated CD8(+) T cells into sensitized and challenged CD8(+)-deficient recipients fails to restore development of lung allergic responses. 1,25D3 alters vitamin D receptor (VDR) recruitment to the Cyp11a1 promoter in vitro and in vivo in the presence of IL-4. As a result, protein levels and enzymatic activity of CYP11A1, a steroidogenic enzyme regulating CD8(+) T-cell conversion, are decreased. An epistatic effect between CYP11A1 and VDR polymorphisms may contribute to the predisposition to childhood asthma. These data identify a role for 1,25D3 in the molecular programming of CD8(+) T-cell conversion to an IL-13-secreting phenotype through regulation of steroidogenesis, potentially governing asthma susceptibility. PMID:26750596

  9. Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

    PubMed Central

    Krejcik, Jakub; Casneuf, Tineke; Nijhof, Inger S.; Verbist, Bie; Bald, Jaime; Plesner, Torben; Syed, Khaja; Liu, Kevin; van de Donk, Niels W. C. J.; Weiss, Brendan M.; Ahmadi, Tahamtan; Lokhorst, Henk M.; Mutis, Tuna

    2016-01-01

    Daratumumab targets CD38-expressing myeloma cells through a variety of immune-mediated mechanisms (complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and antibody-dependent cellular phagocytosis) and direct apoptosis with crosslinking. These mechanisms may also target nonplasma cells that express CD38, which prompted evaluation of daratumumab’s effects on CD38-positive immune subpopulations. Peripheral blood (PB) and bone marrow (BM) from patients with relapsed/refractory myeloma from 2 daratumumab monotherapy studies were analyzed before and during therapy and at relapse. Regulatory B cells and myeloid-derived suppressor cells, previously shown to express CD38, were evaluated for immunosuppressive activity and daratumumab sensitivity in the myeloma setting. A novel subpopulation of regulatory T cells (Tregs) expressing CD38 was identified. These Tregs were more immunosuppressive in vitro than CD38-negative Tregs and were reduced in daratumumab-treated patients. In parallel, daratumumab induced robust increases in helper and cytotoxic T-cell absolute counts. In PB and BM, daratumumab induced significant increases in CD8+:CD4+ and CD8+:Treg ratios, and increased memory T cells while decreasing naïve T cells. The majority of patients demonstrated these broad T-cell changes, although patients with a partial response or better showed greater maximum effector and helper T-cell increases, elevated antiviral and alloreactive functional responses, and significantly greater increases in T-cell clonality as measured by T-cell receptor (TCR) sequencing. Increased TCR clonality positively correlated with increased CD8+ PB T-cell counts. Depletion of CD38+ immunosuppressive cells, which is associated with an increase in T-helper cells, cytotoxic T cells, T-cell functional response, and TCR clonality, represents possible additional mechanisms of action for daratumumab and deserves further exploration. PMID:27222480

  10. Viable School Improvement Requires a Developmental Strategy that Moves beyond the Skewed Wish List and Reworks Operational Infrastructure. A Center Brief

    ERIC Educational Resources Information Center

    Center for Mental Health in Schools at UCLA, 2011

    2011-01-01

    factors affecting learning and teaching and how the operational infrastructure is reworked to enable strategic and effective development of essential interventions. This is especially so for schools that…

  11. The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart

    PubMed Central

    Haan, Serge; Bahlawane, Christelle; Wang, Jiali; Nazarov, Petr V; Muller, Arnaud; Eulenfeld, René; Haan, Claude; Rolvering, Catherine; Vallar, Laurent; Satagopam, Venkata P; Sauter, Thomas; Wiesinger, Monique Yvonne

    2015-01-01

    Aberrant activation of oncogenic kinases is frequently observed in human cancers, but the underlying mechanism and resulting effects on global signaling are incompletely understood. Here, we demonstrate that the oncogenic FIP1L1-PDGFRα kinase exhibits a significantly different signaling pattern compared to its PDGFRα wild type counterpart. Interestingly, the activation of primarily membrane-based signal transduction processes (such as PI3-kinase- and MAP-kinase- pathways) is remarkably shifted toward a prominent activation of STAT factors. This diverging signaling pattern compared to classical PDGF-receptor signaling is partially coupled to the aberrant cytoplasmic localization of the oncogene, since membrane targeting of FIP1L1-PDGFRα restores activation of MAPK- and PI3K-pathways. In stark contrast to the classical cytokine-induced STAT activation process, STAT activation by FIP1L1-PDGFRα does neither require Janus kinase activity nor Src kinase activity. Furthermore, we investigated the mechanism of STAT5 activation via FIP1L1-PDGFRα in more detail and found that STAT5 activation does not involve an SH2-domain-mediated binding mechanism. We thus demonstrate that STAT5 activation occurs via a non-canonical activation mechanism in which STAT5 may be subject to a direct phosphorylation by FIP1L1-PDGFRα. PMID:26413425

  12. Endostatin inhibits the growth and migration of 4T1 mouse breast cancer cells by skewing macrophage polarity toward the M1 phenotype.

    PubMed

    Guo, Hua; Liu, Yanan; Gu, Junlian; Wang, Yue; Liu, Lianqin; Zhang, Ping; Li, Yang

    2016-06-01

    The phenotypic diversity of tumor-associated macrophages (TAMs) increases with tumor development. One of the hallmarks of malignancy is the polarization of TAMs from a pro-immune (M1) phenotype to an immunosuppressive (M2) phenotype. However, the molecular basis of this process is still unclear. Endostatin is a powerful inhibitor of angiogenesis capable of suppressing tumor growth and metastasis. Here, we demonstrate that endostatin induces RAW264.7 cell polarization toward the M1 phenotype in vitro. Endostatin has no effect on TAM numbers in vivo, but results in an increased proportion of F4/80(+)Nos2(+) cells and a decreased proportion of F4/80(+)CD206(+) cells. Overexpression of endostatin in RAW264.7 cells resulted in a decrease in the phosphorylation of STAT3, an increase in expression of vascular endothelial growth factor A and placental growth factor, and an increase in the phosphorylation of STAT1, IκBα and p65 proteins compared with controls. These results indicate that endostatin regulates macrophage polarization, promoting the M1 phenotype by targeting NF-κB and STAT signaling. PMID:27034233

  13. 1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter

    PubMed Central

    Schedel, Michaela; Jia, Yi; Michel, Sven; Takeda, Katsuyuki; Domenico, Joanne; Joetham, Anthony; Ning, Fangkun; Strand, Matthew; Han, Junyan; Wang, Meiqin; Lucas, Joseph J.; Vogelberg, Christian; Kabesch, Michael; O'Connor, Brian P.; Gelfand, Erwin W.

    2016-01-01

    Effector CD8+ T cells convert from IFN-γ+ (Tc1) to IL-13+ (Tc2) cells in the presence of IL-4. Underlying regulatory mechanisms are not fully defined. Here, we show that addition of 1,25D3, the active form of vitamin D3, during CD8+ T-cell differentiation prevents IL-4-induced conversion to IL-13-producers. Transfer of 1,25D3-treated CD8+ T cells into sensitized and challenged CD8+-deficient recipients fails to restore development of lung allergic responses. 1,25D3 alters vitamin D receptor (VDR) recruitment to the Cyp11a1 promoter in vitro and in vivo in the presence of IL-4. As a result, protein levels and enzymatic activity of CYP11A1, a steroidogenic enzyme regulating CD8+ T-cell conversion, are decreased. An epistatic effect between CYP11A1 and VDR polymorphisms may contribute to the predisposition to childhood asthma. These data identify a role for 1,25D3 in the molecular programming of CD8+ T-cell conversion to an IL-13-secreting phenotype through regulation of steroidogenesis, potentially governing asthma susceptibility. PMID:26750596

  14. Dead Lactobacillus plantarum Stimulates and Skews Immune Responses toward T helper 1 and 17 Polarizations in RAW 264.7 Cells and Mouse Splenocytes.

    PubMed

    Lee, Hyun Ah; Kim, Hyunung; Lee, Kwang-Won; Park, Kun-Young

    2016-03-28

    This study was undertaken to evaluate the immunomodulatory effect of dead nano-sized Lactobacillus plantarum (nLp) in RAW 264.7 cells and murine primary splenocytes. nLp is a dead, shrunken, processed form of L. plantarum nF1 isolated from kimchi (a traditional Korean fermented cabbage) and is less than 1 μm in size. It was found that nLp treatment stimulated nitric oxide (NO) production more in RAW 264.7 macrophages than pure live L. plantarum (pLp), and that the stimulatory properties were probably largely derived from its cell wall. In addition, nLp induced murine splenocyte proliferation more so than pLp; in particular, a high dose of nLp (1.0 X 10(11) CFU/ml) stimulated proliferation as much as lipopolysaccharide at 2 μg/ml. Moreover, according to our cytokine profile results in splenocytes, nLp treatment promoted Th1 (TNF-α, IL-12 p70) responses rather than Th2 (IL-4, IL-5) responses and also increased Th17 (IL-6, IL-17A) responses. Thus, nLp stimulated NO release in RAW 264.7 cells and induced splenocyte proliferation more so than pLp and stimulated Th1 and Th17 cytokine production. These findings suggested that dead nLp has potential use as a functional food ingredient to improve the immune response, and especially as a means of inducing Th1/Th17 immune responses. PMID:26699750

  15. Amniotic membrane mesenchymal cells-derived factors skew T cell polarization toward Treg and downregulate Th1 and Th17 cells subsets.

    PubMed

    Pianta, Stefano; Bonassi Signoroni, Patrizia; Muradore, Ivan; Rodrigues, Melissa Francis; Rossi, Daniele; Silini, Antonietta; Parolini, Ornella

    2015-06-01

    We previously demonstrated that cells derived from the mesenchymal layer of the human amniotic membrane (hAMSC) and their conditioned medium (CM-hAMSC) modulate lymphocyte proliferation in a dose-dependent manner. In order to understand the mechanisms involved in immune regulation exerted by hAMSC, we analyzed the effects of CM-hAMSC on T-cell polarization towards Th1, Th2, Th17, and T-regulatory (Treg) subsets. We show that CM-hAMSC equally suppresses the proliferation of both CD4(+) T-helper (Th) and CD8(+) cytotoxic T-lymphocytes. Moreover, we prove that the CM-hAMSC inhibitory ability affects both central (CD45RO(+)CD62L(+)) and effector memory (CD45RO(+)CD62L(-)) subsets. We evaluated the phenotype of CD4(+) cells in the MLR setting and showed that CM-hAMSC significantly reduced the expression of markers associated to the Th1 (T-bet(+)CD119(+)) and Th17 (RORγt(+)CD161(+)) populations, while having no effect on the Th2 population (GATA3(+)CD193(+)/GATA3(+)CD294(+)cells). T-cell subset modulation was substantiated through the analysis of cytokine release for 6 days during co-culture with alloreactive T-cells, whereby we observed a decrease in specific subset-related cytokines, such as a decrease in pro-inflammatory, Th1-related (TNFα, IFNγ, IL-1β), Th2 (IL-5, IL-6), Th9 (IL-9), and Th17 (IL-17A, IL-22). Furthermore, CM-hAMSC significantly induced the Treg compartment, as shown by an induction of proliferating CD4(+)FoxP3(+) cells, and an increase of CD25(+)FoxP3(+) and CD39(+)FoxP3(+) Treg in the CD4(+) population. Induction of Treg cells was corroborated by the increased secretion of TGF-β. Taken together, these data strengthen the findings regarding the immunomodulatory properties of CM-hAMSC derived from human amniotic membrane MSC, and in particular provide insights into their effect on regulation of T cell polarization. PMID:25348066

  16. Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets.

    PubMed

    Brodin, Petter; Lakshmikanth, Tadepally; Kärre, Klas; Höglund, Petter

    2012-03-01

    A major task for the immune system is to secure powerful immune reactions while preserving self-tolerance. This process is particularly challenging for NK cells, for which tolerizing inhibitory receptors for self-MHC class I is both cross-reactive and expressed in an overlapping fashion between NK cells. We show in this study that during an education process, self-MHC class I molecules enrich for potentially useful and contract potentially dangerous NK cell subsets. These processes were quantitatively controlled by the expression level of the educating MHC class I allele, correlated with susceptibility to IL-15 and sensitivity to apoptosis in relevant NK cell subsets, and were linked to their functional education. Controlling the size of NK cell subsets with unique compositions of inhibitory receptors may represent one mechanism by which self-MHC class I molecules generate a population of tolerant NK cells optimally suited for efficient missing self-recognition. PMID:22287714

  17. Wiskott-Aldrich syndrome in a girl caused by heterozygous WASP mutation and extremely skewed X-chromosome inactivation: a novel association with maternal uniparental isodisomy 6.

    PubMed

    Takimoto, Tomohito; Takada, Hidetoshi; Ishimura, Masataka; Kirino, Makiko; Hata, Kenichiro; Ohara, Osamu; Morio, Tomohiro; Hara, Toshiro

    2015-01-01

    Wiskott-Aldrich syndrome (WAS) is an X-linked disease characterized by microthrombocytopenia, eczema and immune deficiency, caused primarily by mutations in the WASP (Wiskott-Aldrich syndrome protein) gene. Female carriers are usually asymptomatic because of the preferential activation of the normal, nonmutated X-chromosome in their hematopoietic cells. We report our observations of a female child with WAS, who displayed symptoms of congenital thrombocytopenia. DNA sequencing analysis of the WASP gene revealed a heterozygous nonsense mutation in exon 10. The expressions of WASP and normal WASP mRNA were defective. We found preferential inactivation of the X-chromosome on which wild-type WASP was located. Single-nucleotide polymorphism microarray testing and the analysis of the polymorphic variable number of tandem repeat regions revealed maternal uniparental isodisomy of chromosome 6 (UPD6). Our results underscore the importance of WASP evaluation in females with congenital thrombocytopenia and suggest that UPD6 might be related to the pathophysiology of nonrandom X-chromosome inactivation. PMID:25633059

  18. Tumor stroma-derived factors skew monocyte to dendritic cell differentiation toward a suppressive CD14+ PD-L1+ phenotype in prostate cancer

    PubMed Central

    Spary, Lisa K; Salimu, Josephine; Webber, Jason P; Clayton, Aled; Mason, Malcolm D; Tabi, Zsuzsanna

    2014-01-01

    Tumor-associated stromal myofibroblasts are essential for the progression and metastatic spread of solid tumors. Corresponding myeloid cell infiltration into primary tumors is a negative prognostic factor in some malignancies. The aim of this study was to define the exact role of stromal myofibroblasts and stromal factors in early prostate carcinoma (PCa) regulating monocyte infiltration and differentiation into dendritic cells (DCs). Epithelial and stromal primary cultures were generated from PCa biopsies and their purity confirmed. Stromal cells produced significantly more of the (C–C) motif chemokine ligand 2 (CCL2), interleukin 6 (IL-6) and transforming growth factor β (TGFβ) than epithelial cells. Monocyte chemoattraction was predominantly due to stromal-derived factors, mainly CCL2. DCs generated in the presence of stromal (but not epithelial) factors upregulated CD209, but failed to downregulate the monocyte marker CD14 in a signal transducer and activator of transcription 3 (STAT3)-dependent manner. Monocytes exposed to stromal factors did not produce detectable amounts of IL-10, however, upon lipopolysaccharide stimulation, stromal factor generated dendritic cells (sDC) produced significantly more IL-10 and less IL-12 than their conventional DC counterparts. sDC failed to cross-present tumor-antigen to CD8+ T cells and suppressed T-cell proliferation. Most importantly, sDC expressed significantly elevated levels of programmed cell death ligand-1 (PD-L1) in a primarily STAT3 and IL-6-dependent manner. In parallel with our findings in vitro, tumor-infiltrating CD14+ cells in situ were found to express both PD-L1 and CD209, and a higher percentage of tumor-associated CD3+ T cells expressed programmed cell death-1 (PD-1) molecules compared to T cells in blood. These results demonstrate a hitherto undescribed, fundamental contribution of tumor-associated stromal myofibroblasts to the development of an immunosuppressive microenvironment in early PCa. PMID:25941611

  19. Wind tunnel research comparing lateral control devices, particularly at high angles of attack VIII : straight and skewed ailerons on wings with rounded tips

    NASA Technical Reports Server (NTRS)

    Weick, Fred E; Shortal, Joseph A

    1933-01-01

    Tests showed the effect of the ailerons and the tip shapes on the general performance of the wing, as well as on the lateral control and stability characteristics. The hinge moments were not measured but the approximate values are given in the first report of the series.

  20. Indexing the relative abundance of age-0 white sturgeons in an impoundment of the lower Columbia River from highly skewed trawling data

    USGS Publications Warehouse

    Counihan, T.D.; Miller, A.I.; Parsley, M.J.

    1999-01-01

    The development of recruitment monitoring programs for age-0 white sturgeons Acipenser transmontanus is complicated by the statistical properties of catch-per-unit-effort (CPUE) data. We found that age-0 CPUE distributions from bottom trawl surveys violated assumptions of statistical procedures based on normal probability theory. Further, no single data transformation uniformly satisfied these assumptions because CPUE distribution properties varied with the sample mean (??(CPUE)). Given these analytic problems, we propose that an additional index of age-0 white sturgeon relative abundance, the proportion of positive tows (Ep), be used to estimate sample sizes before conducting age-0 recruitment surveys and to evaluate statistical hypothesis tests comparing the relative abundance of age-0 white sturgeons among years. Monte Carlo simulations indicated that Ep was consistently more precise than ??(CPUE), and because Ep is binomially rather than normally distributed, surveys can be planned and analyzed without violating the assumptions of procedures based on normal probability theory. However, we show that Ep may underestimate changes in relative abundance at high levels and confound our ability to quantify responses to management actions if relative abundance is consistently high. If data suggest that most samples will contain age-0 white sturgeons, estimators of relative abundance other than Ep should be considered. Because Ep may also obscure correlations to climatic and hydrologic variables if high abundance levels are present in time series data, we recommend ??(CPUE) be used to describe relations to environmental variables. The use of both Ep and ??(CPUE) will facilitate the evaluation of hypothesis tests comparing relative abundance levels and correlations to variables affecting age-0 recruitment. Estimated sample sizes for surveys should therefore be based on detecting predetermined differences in Ep, but data necessary to calculate ??(CPUE) should also be collected.

  1. Skew photonic Doppler velocimetry to investigate the expansion of a cloud of droplets created by micro-spalling of laser shock-melted metal foils

    SciTech Connect

    Loison, D.; Resseguier, T. de; Dragon, A.; Mercier, P.; Benier, J.; Deloison, G.; Lescoute, E.; Sollier, A.

    2012-12-01

    Dynamic fragmentation in the liquid state after shock-induced melting, usually referred to as micro-spallation, is an issue of great interest for both basic and applied sciences. Recent efforts have been devoted to the characterization of the resulting ejecta, which consist in a cloud of fine molten droplets. Major difficulties arise from the loss of free surface reflectivity at shock breakout and from the wide distribution of particle velocities within this cloud. We present laser shock experiments on tin and aluminium, to pressures ranging from about 70 to 160 GPa, with complementary diagnostics including a photonic Doppler velocimeter set at a small tilt angle from the normal to the free surface, which enables probing the whole cloud of ejecta. The records are roughly consistent with a one-dimensional theoretical description accounting for laser shock loading, wave propagation, phase transformations, and fragmentation. The main discrepancies between measured and calculated velocity profiles are discussed in terms of edge effects evidenced by transverse shadowgraphy.

  2. Adjusting skewness and maximum 0.5 hour intensity in CLIGEN to improve extreme event and sub-daily intensity generation for assessing climate change impacts

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Both measured data and GCM/RCM projections show an general increasing trend in extreme rainfall events as temperature rises in US. Proper simulation of extreme events is particularly important for assessing climate change impacts on soil erosion and hydrology. The objective of this paper is to fin...

  3. A Model Comparison for Count Data with a Positively Skewed Distribution with an Application to the Number of University Mathematics Courses Completed

    ERIC Educational Resources Information Center

    Liou, Pey-Yan

    2009-01-01

    The current study examines three regression models: OLS (ordinary least square) linear regression, Poisson regression, and negative binomial regression for analyzing count data. Simulation results show that the OLS regression model performed better than the others, since it did not produce more false statistically significant relationships than…

  4. Rheumatoid arthritis onset in postmenopausal women: Does the ACPA seropositive subset result from genetic effects, estrogen deficiency, skewed profile of CD4(+) T-cells, and their interactions?

    PubMed

    Sapir-Koren, Rony; Livshits, Gregory

    2016-08-15

    Rheumatoid arthritis (RA) incidence displays a differentiated age-dependent female-to-male ratio in which women outnumber men. Evidence that the peak incidence of RA in women coincides with menopause age, suggests a potential estrogenic role to disease etiology. Estrogens exert physiologically both stimulatory and inhibitory effects on the immune system. Epidemiologic and animal model studies with estrogen deprivation or supplementation suggested estrogens as to play, mainly, a protective role in RA immunopathology. In this review, we propose that some yet unidentified disturbances associated with estrogen circulating levels, differentiated by the menopausal status, play a major role in women's RA susceptibility. We focus on the interaction between estrogen deprivation and genetic risk alleles for anti-citrullinated protein antibodies (ACPA) seropositive RA, as a major driving force for increased immune reactivity and RA susceptibility, in postmenopausal women. This opens up new fields for research concerning the association among different irregular estrogenic conditions, the cytokine milieu, and age/menopausal status bias in RA. PMID:27178986

  5. Vaccine-Induced Antibody Isotypes Are Skewed by Impaired CD4 T Cell and Invariant NKT Cell Effector Responses in MyD88-Deficient Mice1

    PubMed Central

    Iweala, Onyinye I.; Smith, Donald W.; Matharu, Kabir S.; Sada-Ovalle, Isabel; Nguyen, Deanna D.; DeKruyff, Rosemarie H.; Umetsu, Dale T.; Behar, Samuel M.; Nagler, Cathryn R.

    2015-01-01

    The requirement for TLR signaling in the initiation of an Ag-specific Ab response is controversial. In this report we show that a novel OVA-expressing recombinant Salmonella vaccine (Salmonella-OVA) elicits a Th1-biased cell-mediated and serum Ab response upon oral or i.p. immunization of C57BL/6 mice. In MyD88−/−mice, Th1-dependent Ab responses are greatly reduced while Th2-dependent Ab isotypes are elevated in response to oral and i.p., but not s.c. footpad, immunization. When the T effector response to oral vaccination is examined we find that activated, adoptively transferred Ag-specific CD4+ T cells accumulate in the draining lymph nodes, but fail to produce IFN-γ, in MyD88−/− mice. Moreover, CD1d tetramer staining shows that invariant NKT cells are activated in response to oral Salmonella-OVA vaccination in wild-type, but not MyD88−/−, mice. Treatment with neutralizing Ab to CD1d reduces the OVA-specific Ab response only in MyD88-sufficient wild-type mice, suggesting that both Ag-specific CD4 T cell and invariant NKT cell effector responses to Salmonella-OVA vaccination are MyD88 dependent. Taken together, our data indicate that the type of adaptive immune response generated to this live attenuated vaccine is regulated by both the presence of MyD88-mediated signals and vaccination route, which may have important implications for future vaccine design. PMID:19620295

  6. Relationship Among the Number of Sub-Tests; Skewness, Kurtosis, and Size of Population; And Magnitude of Errors of Estimate in Multiple Matrix Sampling. (Revised Version).

    ERIC Educational Resources Information Center

    Misanchuk, Earl R.

    Multiple matrix sampling of three subscales of the California Psychological Inventory was used to investigate the effects of four variables on error estimates of the mean (EEM) and variance (EEV). The four variables were examinee population size (600, 450, 300, 150, 100, and 75); number of subtests, (2, 3, 4, 5, 6, and 7), hence the number of…

  7. Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: Low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life

    PubMed Central

    Belderbos, M.E.; van Bleek, G.M.; Levy, O.; Blanken, M.O.; Houben, M.L.; Schuijff, L.; Kimpen, J.L.L.; Bont, L.

    2010-01-01

    Newborns are highly susceptible to infectious diseases, which may be due to impaired immune responses. This study aims to characterize the ontogeny of neonatal TLR-based innate immunity during the first month of life. Cellularity and Toll-like receptor (TLR) agonist-induced cytokine production were compared between cord blood obtained from healthy neonates born after uncomplicated gestation and delivery (n=18), neonatal venous blood obtained at the age of one month (n=96), and adult venous blood (n=17). Cord blood TLR agonist-induced production of the Th1-polarizing cytokines IL-12p70 and IFN-α was generally impaired, but for TLR3, 7 and 9 agonists, rapidly increased to adult levels during the first month of life. In contrast, TLR4 demonstrated a slower maturation, with low LPS-induced IL-12p70 production and high IL-10 production up until the age of one month. Polarization in neonatal cytokine responses to LPS could contribute to neonatal susceptibility to severe bacterial infection. PMID:19648060

  8. System and method for adaptively deskewing parallel data signals relative to a clock

    DOEpatents

    Jenkins, Philip Nord; Cornett, Frank N.

    2008-10-07

    A system and method of reducing skew between a plurality of signals transmitted with a transmit clock is described. Skew is detected between the received transmit clock and each of received data signals. Delay is added to the clock or to one or more of the plurality of data signals to compensate for the detected skew. The delay added to each of the plurality of delayed signals is updated to adapt to changes in detected skew.

  9. System and method for adaptively deskewing parallel data signals relative to a clock

    DOEpatents

    Jenkins, Philip Nord; Cornett, Frank N.

    2011-10-04

    A system and method of reducing skew between a plurality of signals transmitted with a transmit clock is described. Skew is detected between the received transmit clock and each of received data signals. Delay is added to the clock or to one or more of the plurality of data signals to compensate for the detected skew. The delay added to each of the plurality of delayed signals is updated to adapt to changes in detected skew.

  10. Distribution functions for statistics derived from bivariate normal and bivariate two-parameter log-normal populations

    USGS Publications Warehouse

    Slack, James Richard; Matalas, Nicholas C.; Wallis, James R.

    1976-01-01

    The distribution functions for hydrologic statistics that may be used to assess the significance of differences between sample means, standard deviations, coefficients of skewness, and coefficients of variations are obtained by Monte Carlo experiments. The distributions are expressed as functions of sample size, cross correlation, and skewness. In general, the distributions are more sensitive to cross correlation than to skewness. As sample size increases, however, the distributions tend to become more sensitive to skewness. (Woodard-USGS)

  11. Microwave Studies on 1,4-Pentadiene: CH2═CH-CH2-CH═CH2; Transformations among the Three Rotational Isomers

    NASA Astrophysics Data System (ADS)

    Hirota, Eizi; Watanabe, Ryo; Kawashima, Yoshiyuki; Shigemune, Toshiaki; Matsumoto, Juichi; Murakami, Kenji; Mizoguchi, Asao; Kanamori, Hideto; Nakajima, Masakazu; Endo, Yasuki; Sumiyoshi, Yoshihiro

    2013-10-01

    In order to examine significant roles of conformations played in various research fields, a molecule with two internal-rotation axes of high symmetry, 1,4-pentadiene, was studied in detail through the observation of its rotational spectra by using various types of microwave spectroscopy, Stark modulation and Fourier transform in the centimeter-wave region, direct absorption in the millimeter-wave region, and centimeter-/millimeter-wave combinations for double resonance, along with ab initio molecular orbital calculations. The molecule was confirmed to exist in three rotameric forms: skew-skew, cis-skew, and skew-skew-. For the cis-skew form, rotational spectra not only in the ground vibrational state, but also in three excited C-C torsional states were detected. Rotational and centrifugal distortion constants were precisely determined by the analysis of all the observed spectra, in addition to the relative energies of the three isomers and the torsional frequencies for the cis-skew form, as estimated from the observed spectral line intensities. The skew-skew form was found to be the most stable among the three isomers, the cis-skew form higher in energy than the skew-skew by 172 ± 66 cm-1, and the skew-skew- form higher in energy than the cis-skew by 44 ± 26 cm-1. These experimental results were compared with those derived from a two-dimensional potential energy surface calculated by ab initio molecular orbital methods, in order to obtain a global view of molecular dynamics taking place on the surface, while paying attention to unique features of internal rotation characteristic of two dimensions.

  12. System and method for adaptively deskewing parallel data signals relative to a clock

    DOEpatents

    Jenkins, Philip Nord; Cornett, Frank N.

    2006-04-18

    A system and method of reducing skew between a plurality of signals transmitted with a transmit clock is described. Skew is detected between the received transmit clock and each of received data signals. Delay is added to the clock or to one or more of the plurality of data signals to compensate for the detected skew. Each of the plurality of delayed signals is compared to a reference signal to detect changes in the skew. The delay added to each of the plurality of delayed signals is updated to adapt to changes in the detected skew.

  13. Commingling in the distributions of fat-related measures in Punjabi families.

    PubMed

    Sharma, K; Byard, P J; Rao, D C

    1984-01-01

    The distribution of anthropometric measurements related to fatness levels is examined to determine if skewness alone accounts for the nonnormality of such measures. A mixture of two normal distributions or a single skewed distribution fit the data significantly better than a single normal in all cases. For maximum hip width, knee diameter, and weight, two skewed distributions give a better fit than one skewed distribution, rejecting the null hypothesis of a single distribution even when skewness is considered. There is evidence for three skewed component distributions for biceps skinfold. Abdomen circumference, upper arm circumference, triceps skinfold, and calf skinfold are best approximated by a one component log-normal distribution. Children and parents show slightly different patterns in skewness and kurtosis when considered separately, but differences between them do not account for the commingling found in the combined distributions. PMID:6479997

  14. Preference for luminance histogram regularities in natural scenes.

    PubMed

    Graham, Daniel; Schwarz, Bianca; Chatterjee, Anjan; Leder, Helmut

    2016-03-01

    Natural scene luminance distributions typically have positive skew, and for single objects, there is evidence that higher skew is a correlate (but not a guarantee) of glossiness. Skewness is also relevant to aesthetics: preference for glossy single objects (with high skew) has been shown even in infants, and skewness is a good predictor of fruit freshness. Given that primate vision appears to efficiently encode natural scene luminance variation, and given evidence that natural scene regularities may be a prerequisite for aesthetic perception in the spatial domain, here we ask whether humans in general prefer natural scenes with more positively skewed luminance distributions. If humans generally prefer images with the higher-order regularities typical of natural scenes and/or shiny objects, we would expect this to be the case. By manipulating luminance distribution skewness (holding mean and variance constant) for individual natural images, we show that in fact preference varies inversely with increasing positive skewness. This finding holds for: artistic landscape images and calibrated natural scenes; scenes with and without glossy surfaces; landscape scenes and close-up objects; and noise images with natural luminance histograms. Across conditions, humans prefer images with skew near zero over higher skew images, and they prefer skew lower than that of the unmodified scenes. These results suggest that humans prefer images with luminances that are distributed relatively evenly about the mean luminance, i.e., images with similar amounts of light and dark. We propose that our results reflect an efficient processing advantage of low-skew images over high-skew images, following evidence from prior brain imaging results. PMID:25872178

  15. Momentum energy of the non-radiating electromagnetic field: open problems?

    NASA Astrophysics Data System (ADS)

    Kholmetskii, Alexander L.

    2006-06-01

    This paper inspects more closely the problem of the momentum and energy of a bound (non-radiative) electromagnetic (EM) field. It has been shown that for an isolating system of non-radiative non-relativistic mechanically free charged particles, a transformation of mechanical to EM momentum and vice versa occurs in accordance with the requirement \\skew3\\vec{P}_G =const, where \\skew3\\vec{P}_G = \\skew3\\vec{P}_M + \\sum\

  16. Magnetic measurements of the correction and adjustment magnets of the main ring

    SciTech Connect

    Trbojevic, D.

    1986-07-01

    Correction magnets correct the field imperfections and alignment errors of the main quadrupole and bend magnets. For reducing and controlling chromaticity there are 186 sextupoles and 78 octupoles, while for suppressing various resonances there are 12 normal and 18 skew sextupoles and 24 normal and 19 skew quadrupoles. Beam positions are individually controlled by 108 horizontal and 108 skew dipoles. This report includes results of the all Main Ring correction and adjustment magnet harmonic measurements. The measurement principle and basic equations are described.

  17. Tailoring the laser pulse shape to improve the quality of the self-injected electron beam in laser wakefield acceleration

    SciTech Connect

    Upadhyay, Ajay K.; Samant, Sushil A.; Krishnagopal, S.

    2013-01-15

    In laser wakefield acceleration, tailoring the shape of the laser pulse is one way of influencing the laser-plasma interaction and, therefore, of improving the quality of the self-injected electron beam in the bubble regime. Using three-dimensional particle-in-cell simulations, the evolution dynamics of the laser pulse and the quality of the self-injected beam, for a Gaussian pulse, a positive skew pulse (i.e., one with sharp rise and slow fall), and a negative skew pulse (i.e., one with a slow rise and sharp fall) are studied. It is observed that with a negative skew laser pulse there is a substantial improvement in the emittance (by around a factor of two), and a modest improvement in the energy-spread, compared to Gaussian as well as positive skew pulses. However, the injected charge is less in the negative skew pulse compared to the other two. It is also found that there is an optimal propagation distance that gives the best beam quality; beyond this distance, though the energy increases, the beam quality deteriorates, but this deterioration is least for the negative skew pulse. Thus, the negative skew pulse gives an improvement in terms of beam quality (emittance and energy spread) over what one can get with a Gaussian or positive skew pulse. In part, this is because of the lesser injected charge, and the strong suppression of continuous injection for the negative skew pulse.

  18. Facing Imbalanced Data Recommendations for the Use of Performance Metrics

    PubMed Central

    Jeni, László A.; Cohn, Jeffrey F.; De La Torre, Fernando

    2014-01-01

    Recognizing facial action units (AUs) is important for situation analysis and automated video annotation. Previous work has emphasized face tracking and registration and the choice of features classifiers. Relatively neglected is the effect of imbalanced data for action unit detection. While the machine learning community has become aware of the problem of skewed data for training classifiers, little attention has been paid to how skew may bias performance metrics. To address this question, we conducted experiments using both simulated classifiers and three major databases that differ in size, type of FACS coding, and degree of skew. We evaluated influence of skew on both threshold metrics (Accuracy, F-score, Cohen's kappa, and Krippendorf's alpha) and rank metrics (area under the receiver operating characteristic (ROC) curve and precision-recall curve). With exception of area under the ROC curve, all were attenuated by skewed distributions, in many cases, dramatically so. While ROC was unaffected by skew, precision-recall curves suggest that ROC may mask poor performance. Our findings suggest that skew is a critical factor in evaluating performance metrics. To avoid or minimize skew-biased estimates of performance, we recommend reporting skew-normalized scores along with the obtained ones. PMID:25574450

  19. Weak interactions, omnivory and emergent food-web properties.

    PubMed Central

    Emmerson, Mark; Yearsley, Jon M.

    2004-01-01

    Empirical studies have shown that, in real ecosystems, species-interaction strengths are generally skewed in their distribution towards weak interactions. Some theoretical work also suggests that weak interactions, especially in omnivorous links, are important for the local stability of a community at equilibrium. However, the majority of theoretical studies use uniform distributions of interaction strengths to generate artificial communities for study. We investigate the effects of the underlying interaction-strength distribution upon the return time, permanence and feasibility of simple Lotka-Volterra equilibrium communities. We show that a skew towards weak interactions promotes local and global stability only when omnivory is present. It is found that skewed interaction strengths are an emergent property of stable omnivorous communities, and that this skew towards weak interactions creates a dynamic constraint maintaining omnivory. Omnivory is more likely to occur when omnivorous interactions are skewed towards weak interactions. However, a skew towards weak interactions increases the return time to equilibrium, delays the recovery of ecosystems and hence decreases the stability of a community. When no skew is imposed, the set of stable omnivorous communities shows an emergent distribution of skewed interaction strengths. Our results apply to both local and global concepts of stability and are robust to the definition of a feasible community. These results are discussed in the light of empirical data and other theoretical studies, in conjunction with their broader implications for community assembly. PMID:15101699

  20. Journey to Centers in the Core

    ERIC Educational Resources Information Center

    Groth, Randall E.; Kent, Kristen D.; Hitch, Ebony D.

    2015-01-01

    Considerable discrepancies between the mean and median often occur in data sets that are skewed left, skewed right, or have other unusual features. In such cases, it is important to analyze the data and context carefully to decide how best to describe centers of distributions. The importance of this type of statistical thinking is acknowledged in…