1991-08-01
90-09-25- VRX Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number: 901129W1.11096 Verdix Corporation VADS Sequent Balance DYNIX 3.0, VAda-1lO...8000, DYNIX Version 3.0 Target Computer System: Sequent Balance 8000, DYNIX Version 3.0 Customer Agreement Number: 90-09-25- VRX See Section 3.1 for any
1991-08-01
VRX Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number: 901129W1.11097 Verdix Corporation VADS Sun-4 => 63K, Sun OS 4.0, VAda-110-40125...68030) (bare machine) Customer Agreement Number: 90-09-25- VRX See Section 3.1 for any additional information about the testing environment. As a
DOE Office of Scientific and Technical Information (OSTI.GOV)
Fang, Yi-Bin, E-mail: fangyibin@163.com; Zhao, Kai-Jun, E-mail: zkjwcfzwh@163.com; Wu, Yi-Na, E-mail: wuyina0923@163.com
2015-06-15
PurposeThe treatment of ruptured vertebral artery dissecting aneurysms (VADAs) continues to be controversial. Our goal was to evaluate the safety, efficacy, and long-term outcomes of internal trapping and stent-assisted coiling (SAC) for ruptured VADAs distal to the posterior inferior cerebellar artery (supra-PICA VADAs), which is the most common subset.MethodsA retrospective review was conducted of 39 consecutive ruptured supra-PICA VADAs treated with internal trapping (n = 20) or with SAC (n = 19) at our institution. The clinical and angiographic data were retrospectively compared.ResultsThe immediate total occlusion rate of the VADAs was 80 % in the trapping group, which improved to 88.9 % at the follow-ups (45 monthsmore » on average). Unwanted occlusions of the posterior inferior cerebellar artery (PICA) were detected in three trapped cases. Incomplete obliteration of the VADA or unwanted occlusions of the PICA were detected primarily in the VADAs closest to the PICA. In the stenting group, the immediate total occlusion rate was 47.4 %, which improved to 100 % at the follow-ups (39 months on average). The immediate total occlusion rate of the VADAs was higher in the trapping group (p < 0.05), but the later total occlusion was slightly higher in the stenting group (p > 0.05).ConclusionsOur preliminary results showed that internal trapping and stent-assisted coiling are both technically feasible for treating ruptured supra-PICA VADAs. Although not statistically significant, procedural related complications occurred more frequently in the trapping group. When the VADAs are close to the PICA, we suggest that the lesions should be treated using SAC.« less
Liu, Jian; Jing, Linkai; Zhang, Ying; Song, Ying; Wang, Yang; Li, Chuanhui; Wang, Yanmin; Mu, Shiqing; Paliwal, Nikhil; Meng, Hui; Linfante, Italo; Yang, Xinjian
2017-01-01
Intracranial vertebral artery dissecting aneurysms (VADAs) tend to recur despite successful stent-assisted coil embolization (SACE). Hemodynamics is useful in evaluating aneurysmal formation, growth, and rupture. Our aim was to evaluate the hemodynamic patterns of the recurrence of VADA. Between September 2009 and November 2013, all consecutive patients with recurrent VADAs after SACE in our institutions were enrolled. Recurrence was defined as recanalization and/or regrowth. We assessed the hemodynamic alterations in wall shear stress (WSS) and velocity after the initial SACE and subsequently after retreatment of the aneurysms that recurred. Five patients were included. After the initial treatment, 3 patients showed recanalization and 2 showed regrowth. In the 2 patients with regrowth, the 2 original aneurysms maintained complete occlusion; however, de novo aneurysm regrowth was confirmed near the previous site. Compared with 3 recanalized aneurysms, the completely occluded aneurysms showed high mean reductions in velocity and WSS after initial treatment (velocity, 77.6% vs. 57.7%; WSS, 74.2% vs. 52.4%); however, WSS remained high at the region near the previous lesion where the new aneurysm originated. After the second retreatment, there was no recurrence in any patient. Compared with the 3 aneurysms that recanalized, the 4 aneurysms that maintained complete occlusion showed higher reductions in velocity (62.9%) and WSS (71.1%). Our series indicated that hemodynamics might have an important role in recurrence of VADAs. After endovascular treatment, sufficient hemodynamic reduction in aneurysm dome, orifice, and parent vessel may be one of the key factors for preventing recurrence in VADAs. Copyright © 2016 Elsevier Inc. All rights reserved.
Screening for and Inheritance of Resistance to Barley Leaf Stripe (Drechslera graminea),
1987-12-01
JORGENSEN, J.H. (1986,. Field assessment of partial resistance to powdery mildew in spring barley . Euphytica 35, 233-243. KRISTIANSSON, B. and NILSSON, B...the Laevigatum powdery mildew resistance via ’Vada’ and ’Minerva’. This suggests this resistance to occur in many varieties descending from ’Vada...kept free from powdery mildew by spraying with Bayleton (25% triadimefon WP) both in the greenhouse and in the field. This fungicide does not affect the
2012-01-01
14]. The detector material was processed into a variable area diode array (VADA) of square and circular mesa diodes with the size of diode mesa sides...processed as single element detectors with 410 lm 410 lm square mesas having circular apertures ranging in diameter from 25 to 300 lm. The processing was...passivations schemes with perimeter-to-area ratio (P/A) of 1600 cm1 ( mesa side size is 25 lm). Fig. 3. Inverse of the dynamic resistance area product (RdA
Montubi completes mile-long liquid ethylene pipeline project
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1979-12-01
Montubi has completed the mile-long liquid ethylene pipeline project for Solvay S.p.A. at Vada, Italy, a line that extends 3.4 mi from an offshore unloading dock to an onshore gasification facility for Solvay's chemical plant at Rosignano. The 18 mo project included a mile-long 1750 ton jetty; one eight-leg main unloading platform; eight mooring dolphins plus four breasting dolphins; one small platform for firefighting pump units; and a concrete service road along the jetty.
Primativo, Giuseppina; Ottoni, Claudio; Biondi, Gianfranco; Serafino, Sara; Martínez-Labarga, Cristina; Larmuseau, Maarten H D; Scardi, Michele; Decorte, Ronny; Rickards, Olga
2017-03-01
The understanding of the first movements of the ancestral populations within the African continent is still unclear, particularly in West Africa, due to several factors that have shaped the African genetic pool across time. To improve the genetic representativeness of the Beninese population and to better understand the patterns of human settlement inside West Africa and the dynamics of peopling of the Democratic Republic of Benin, we analyzed the maternal genetic variation of 193 Beninese individuals belonging to Bariba, Berba, Dendi, and Fon populations. Results support the oral traditions indicating that the western neighbouring populations have been the ancestors of the first Beninese populations, and the extant genetic structure of the Beninese populations is most likely the result of admixture between populations from neighbouring countries and native people. The present findings highlight how the Beninese populations contributed to the gene pool of the extant populations of some American populations of African ancestry. This strengthens the hypothesis that the Bight of Benin was not only an assembly point for the slave trade during the Trans-Atlantic Slave Trade but also an important slave trapping area. © 2017 John Wiley & Sons Ltd/University College London.
Levert, Marie-Josée; Lefebvre, Hélène; Gélinas, Isabelle; McKerall, Michelle; Roy, Odette; Proulx, Michelle
2016-06-01
This pilot project aims to test and see the relevance of the direct observation method to collect data on the barriers and facilitators to attending public places by seniors with TBI. The study is based on the conceptual framework VADA WHO which focuses on the development of friendly built and technological environments for seniors. Three elderly people participated in the study, recruited from an ongoing project, The Citizen Intervention in Community Living (APIC), in the presence of their personalized attendant. The study shows the feasibility of the method in terms of its acceptability and resources mobilized. It shows its relevance to access additional data that would have been difficult to obtain using others methods (e.g., semi-structured interview), such as the identification of the strategies used by the participants to address the obstacles encountered (avoidance, travel planning, use of physical and preventative support of the personalized attendant).
1984-11-01
Focus in this discussion of Benin is on the following: the people; geography; history; government and political conditions; economy; defense; foreign relations; and relations between the US and Benin. The population totaled 3.8 million in 1983 with an annual growth rate of 2.6%. The infant mortality rate is 45/1000 and life expectancy 46.9 years. The population comprises about 20 sociocultural groups. 4 groups -- the Fon, Aja, Bariba, and Yoruba -- account for more than half of the population. The name was changed from Dahomey to the People's Republic of Benin in 1975. 2 years after the military coup d'etat in 1972, Marxism-Leninism was declared the guiding philosophy of the new government. Marxism-Leninism remains the official doctrine, but the government has moved to take account of popular resistance to a radical social transformation, as well as problems encountered in attempting to establish a centrally directed economy. Benin is ranked as 1 of the world's 35 poorest countries. The commercial, industrial, and agricultural sectors are all experiencing severe problems. The government's newest 5 year plan for 1983-88 places a stronger emphasis on developing agriculture. In so doing, the government hopes to assure its own domestic needs and to become a supplier of basic foodstuffs to the region. Benin's Armed Forces number about 3000 personnel. Benin is a member of the Non-Aligned Movement and the Organization of African Unity. Relations with France are important because of historical, cultural, economic, and aid links. After 1972, relations between the US and Benin became strained as Benin moved to strengthen its ties with the Soviet Union and other socialist countries and mounted harsh propaganda attacks on the US.
No Turning Back: A Hopi Indian Woman's Struggle to Live in Two Worlds. As Told to Vada F. Carlson.
ERIC Educational Resources Information Center
Qoyawayma, Polingaysi
For high school and adult readers this autobiography of Polingaysi Qoyawayma (Elizabeth Q. White) relates a Hopi Indian woman's struggle to adjust to an alien culture and to develop teaching methods to bridge the gap between Indians and the white world. Information on Hopi legends and ceremonies introduce the reader to the Hopi way of life. Born…
High Diversity of Genes for Nonhost Resistance of Barley to Heterologous Rust Fungi
Jafary, Hossein; Albertazzi, Giorgia; Marcel, Thierry C.; Niks, Rients E.
2008-01-01
Inheritance studies on the nonhost resistance of plants would normally require interspecific crosses that suffer from sterility and abnormal segregation. Therefore, we developed the barley–Puccinia rust model system to study, using forward genetics, the specificity, number, and diversity of genes involved in nonhost resistance. We developed two mapping populations by crossing the line SusPtrit, with exceptional susceptibility to heterologous rust species, with the immune barley cultivars Vada and Cebada Capa. These two mapping populations along with the Oregon Wolfe Barley population, which showed unexpected segregation for resistance to heterologous rusts, were phenotyped with four heterologous rust fungal species. Positions of QTL conferring nonhost resistance in the three mapping populations were compared using an integrated consensus map. The results confirmed that nonhost resistance in barley to heterologous rust species is controlled by QTL with different and overlapping specificities and by an occasional contribution of an R-gene for hypersensitivity. In each population, different sets of loci were implicated in resistance. Few genes were common between the populations, suggesting a high diversity of genes conferring nonhost resistance to heterologous pathogens. These loci were significantly associated with QTL for partial resistance to the pathogen Puccinia hordei and with defense-related genes. PMID:18430953
Rainfall-Induced Release of Fecal Coliforms and Other Manure Constituents: Comparison and Modeling▿
Guber, A. K.; Shelton, D. R.; Pachepsky, Y. A.; Sadeghi, A. M.; Sikora, L. J.
2006-01-01
Modeling release of fecal coliforms is an important component of fate and transport simulations related to environmental water quality. Manure constituents other than fecal coliforms may serve as natural tracers of fecal contamination provided that their release from manure to runoff is similar to the fecal coliform release. The objectives of this work were to compare release of fecal coliforms (FC), chloride (Cl−), organic carbon (OC), and water-soluble phosphorus (P) from dissolving manure and to assess the performance of three models in describing the observed release. Bovine manure was applied on 0.5- by 0.3-m bare and vegetated subplots with 20% slope on sandy loam and clay loam soils. Concentrations of Cl−, FC, OC, and P were measured in runoff collected from troughs at the edges of the subplots at 5-min intervals during 1-h rainfall simulations. The one-parametric exponential model and two-parametric Vadas-Kleinman-Sharpley model and Bradford-Schijven model were fitted to the data. The Bradford-Schijven model had uncorrelated parameters, one of which was linearly related to the irrigation rate, and another parameter reflected the presence or the absence of vegetation. Kinetics of the FC release from manure was similar to the release kinetics of P and OC. The Bradford-Schijven model is recommended to simulate the release of manure constituents. PMID:17028232
Mapping resistance to powdery mildew in barley reveals a large-effect nonhost resistance QTL.
Romero, Cynara C T; Vermeulen, Jasper P; Vels, Anton; Himmelbach, Axel; Mascher, Martin; Niks, Rients E
2018-05-01
Resistance factors against non-adapted powdery mildews were mapped in barley. Some QTLs seem effective only to non-adapted mildews, while others also play a role in defense against the adapted form. The durability and effectiveness of nonhost resistance suggests promising practical applications for crop breeding, relying upon elucidation of key aspects of this type of resistance. We investigated which genetic factors determine the nonhost status of barley (Hordeum vulgare L.) to powdery mildews (Blumeria graminis). We set out to verify whether genes involved in nonhost resistance have a wide effectiveness spectrum, and whether nonhost resistance genes confer resistance to the barley adapted powdery mildew. Two barley lines, SusBgt SC and SusBgt DC , with some susceptibility to the wheat powdery mildew B. graminis f.sp. tritici (Bgt) were crossed with cv Vada to generate two mapping populations. Each population was assessed for level of infection against four B. graminis ff.spp, and QTL mapping analyses were performed. Our results demonstrate polygenic inheritance for nonhost resistance, with some QTLs effective only to non-adapted mildews, while others play a role against adapted and non-adapted forms. Histology analyses of nonhost interaction show that most penetration attempts are stopped in association with papillae, and also suggest independent layers of defence at haustorium establishment and conidiophore formation. Nonhost resistance of barley to powdery mildew relies mostly on non-hypersensitive mechanisms. A large-effect nonhost resistance QTL mapped to a 1.4 cM interval is suitable for map-based cloning.
1993-09-28
APPENDIX B COKPILATIC SYS=Dl OPTI•CS APPENDIX C APPEN4DIX F OF THE Aa STANDRD CHNMP1 1 The a implementation described above was tested according to the Mad...REPORT and CHEK FILE is checked by a set of executable tests. If these units are not opirating correctly, validation testing is discontinued. Class B...sections 2.1 and 2.2 (counted in items b and f , below). 3-1 PC0SSmnG INO nON a) Total Number of Applicable Tests 3809 b) Total Number of Withdrawn Tests
1987-06-21
AD-*I93 60 A (T~r~ OIIP~~~T l UNCL~t Uh 1&0-- is Imf, FILE COPY 0o AVF Control Number: AVF-VSR-100.1087087-04-09- VRX Ada® COMPILER VALIDATION SUMMARY...UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (When Data Entered) AVF Control Number: AVF-VSR-100.0987 87-04-09- VRX Ada ® COMPILER VALIDATION SUMMARY REPORT
NOTCH signalinio kelio ir ginekologinių piktybinių navikų sąsaja
Lachej, Nadežda; Dabkevičienė, Daiva; Sasnauskienė, Aušra; Trimonytė, Rūta Marija; Kanopienė, Daiva; Kazbarienė, Birutė; Didžiapetrienė, Janina
2017-01-01
Įvadas. Organizmo ląstelėse vykstančius procesus kontroliuoja įvairūs signaliniai keliai. Vienas iš jų yra NOTCH signalinis kelias. Nustatyta, kad dalinis NOTCH funkcijos praradimas arba nenormalus NOTCH signalo aktyvinimas susijęs su įvairiais žmogaus vystymosi sutrikimais ir ligomis. Medžiaga ir metodika. Pagrindinis informacijos šaltinis ieškant duomenų – PubMed duomenų bazė. Rezultatai. Straipsnyje nagrinėjama onkologinių ligų bei NOTCH signalinio kelio dalyvių sąsaja. NOTCH signalas, vystantis vėžiui, gali veikti dvejopai: kaip onkogenas ir kaip naviko augimo slopiklis. Tikslus tokio poveikio mechanizmas dar nėra žinomas. NOTCH signalinio kelio tyrimai svarbūs siekiant atrasti naujus vėžio gydymo būdus, farmakologiniais ir genetiniais metodais valdant NOTCH signalinį kelią. Šioje apžvalgoje daugiausia dėmesio skiriama ginekologiniams piktybiniams navikams, ypač gimdos kūno vėžiui. Išvados. Pastarųjų metų mokslinių tyrimų duomenys rodo, kad NOTCH signalinis kelias yra neabejotinai svarbus formuojantis gimdos kūno vėžiui, todėl jo komponentai gali būti potencialūs prognoziniai biožymenys ir molekuliniai terapiniai taikiniai. Siekiant patikslinti NOTCH signalinio kelio dalyvių reikšmę bei jų sąveiką su kitų signalinių kelių dalyviais, kurie taip pat gali būti svarbūs formuojantis ir progresuojant gimdos kūno vėžiui, reikalingi tolesni šios srities moksliniai tyrimai. PMID:28630591
1991-01-17
Number: 90-03-08- VRX See Section 3.1 for any additional information about the testing environment. As a result of this validation effort, Validation...20301,Q:’ I.. AVF Control Number: AVF-VSR-365.0191 17 January 1991 90-03-08- VRX Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number: 900228W1.11003
Developing a Very Low Vision Orientation and Mobility Test Battery (O&M-VLV).
Finger, Robert P; Ayton, Lauren N; Deverell, Lil; O'Hare, Fleur; McSweeney, Shane C; Luu, Chi D; Fenwick, Eva K; Keeffe, Jill E; Guymer, Robyn H; Bentley, Sharon A
2016-09-01
This study aimed to determine the feasibility of an assessment of vision-related orientation and mobility (O&M) tasks in persons with severe vision loss. These tasks may be used for future low vision rehabilitation clinical assessments or as outcome measures in vision restoration trials. Forty legally blind persons (mean visual acuity logMAR 2.3, or hand movements) with advanced retinitis pigmentosa participated in the Orientation & Mobility-Very Low Vision (O&M-VLV) subtests from the Low Vision Assessment of Daily Activities (LoVADA) protocol. Four categories of tasks were evaluated: route travel in three indoor hospital environments, a room orientation task (the "cafe"), a visual exploration task (the "gallery"), and a modified version of the Timed Up and Go (TUG) test, which assesses re-orientation and route travel. Spatial cognition was assessed using the Stuart Tactile Maps test. Visual acuity and visual fields were measured. A generalized linear regression model showed that a number of measures in the O&M-VLV tasks were related to residual visual function. The percentage of preferred walking speed without an aid on three travel routes was associated with visual field (p < 0.01 for all routes) whereas the number of contacts with obstacles during route travel was associated with acuity (p = 0.001). TUG-LV task time was associated with acuity (p = 0.003), as was the cafe time and distance traveled (p = 0.006 and p < 0.001, respectively). The gallery score was the only measure that was significantly associated with both residual acuity and fields (p < 0.001 and p = 0.001, respectively). The O&M-VLV was designed to capture key elements of O&M performance in persons with severe vision loss, which is a population not often studied previously. Performance on these tasks was associated with both binocular visual acuity and visual field. This new protocol includes assessments of orientation, which may be of benefit in vision restoration clinical trials.
1993-02-26
2-89) Prescribed by ANSI Sid 239-128 AVF Control Number: AVF-VSR-561-0293 Date VSR Completed: 15 February 1993 93-01-25- VRX Ada COMPILER VALIDATION...Agreement Number: 93-01-2S- VRX See section 3.1 for any additional information about the testing environment. As a result of this validation effort
1992-03-19
Sun SPARCstation LX 4/30 under Solaris 2.1 Customer Agreement Number: 92-06-23- VRX See section 3.1 for any additional information about the testing...mber: AVF-VSR-556-1092 Date VSR Complete: 18 November 1992 92-06-23- VRX Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number: 921004W1.11285
NASA Astrophysics Data System (ADS)
Aguilar Guerrero, J.; Snively, J. B.
2017-12-01
Acoustic waves (AWs) have been predicted to be detectable by imaging systems for the OH airglow layer [Snively, GRL, 40, 2013], and have been identified in spectrometer data [Pilger et al., JASP, 104, 2013]. AWs are weak in the mesopause region, but can attain large amplitudes in the F region [Garcia et al., GRL, 40, 2013] and have local impacts on the thermosphere and ionosphere. Similarly, fast GWs, with phase speeds over 100 m/s, may propagate to the thermosphere and impart significant local body forcing [Vadas and Fritts, JASTP, 66, 2004]. Both have been clearly identified in ionospheric total electron content (TEC), such as following the 2013 Moore, OK, EF5 tornado [Nishioka et al., GRL, 40, 2013] and following the 2011 Tohoku-Oki tsunami [e.g., Galvan et al., RS, 47, 2012, and references therein], but AWs have yet to be unambiguously imaged in MLT data and fast GWs have low amplitudes near the threshold of detection; nevertheless, recent imaging systems have sufficient spatial and temporal resolution and sensitivity to detect both AWs and fast GWs with short periods [e.g., Pautet et al., AO, 53, 2014]. The associated detectability challenges are related to the transient nature of their signatures and to systematic challenges due to line-of-sight (LOS) effects such as enhancements and cancelations due to integration along aligned or oblique wavefronts and geometric intensity enhancements. We employ a simulated airglow imager framework that incorporates 2D and 3D emission rate data and performs the necessary LOS integrations for synthetic imaging from ground- and space-based platforms to assess relative intensity and temperature perturbations. We simulate acoustic and fast gravity wave perturbations to the hydroxyl layer from a nonlinear, compressible model [e.g., Snively, 2013] for different idealized and realistic test cases. The results show clear signal enhancements when acoustic waves are imaged off-zenith or off-nadir and the temporal evolution of these
1991-01-22
iSBC 386/32, bare machine Customer Agreement Number: 90-05-29- VRX See Section 3.1 for any additional information about the testing environment. As a...Defense Avail and/or Washington DC 20301 -Dist Special ----- ---- i AVF Control Number: AVF-VSR-379.0191 22 January 1991 90-05-29- VRX Ada COMPILER
1992-11-18
Rev. 2-89) Prescribed by ANSI Std. 239-128 AVr Control Number: AVF-VSR-542-1092 Date VSR Complete: 18 November 1992 92-06-23- vRx Ada COMPILER...System: AST Premium 486 under UNIX System V, Release 4.0 Customer Agreement Number: 92-06-23- VRX See section 3.1 for any additional information about
1991-09-20
SunOS Release 4.1.1) Target Computer System: Motorola MVME147 (Motorola 68030 Bare Board) Customer Agreement Number: 91-07-16- VRX See section 3.1 for...AVF-VSR-504.0292 18 February 1992 91-07-1 6- VRX Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number: 910920W1.11211 VERDIX Corporation VADS...SunOS Release 4.1.1) Target Computer System: Motorola MVME147 (Motorola 68030 Bare Board) Customer Agreement Number: 91-07-16- VRX See section 3.1 for
1991-01-22
Customer Agreement Number: 90-05-29- VRX See Section 3.1 for any additional information about the testing environment. As a result of this validation...22 January 1991 90-05-29- VRX Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number: 900726W1.11017 Verdix Corporation VADS IBM RISC System/6000
1991-09-20
Agreement Number: 91-07-16- VRX See section 3.1 for any additional information about the testing environment. As a result of this validation effort...Washington DC 20301 92-06991 AVF Control Number: AVF-VSR-511.0292 18 February 1992 91-07-16- VRX Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number...System: Ironics IV9001 board (AMD 29000) (Am29000 bare VME machine) Customer Agreement Number: 91-07-16- VRX See section 3.1 for any additional information
1991-10-15
Host Customer Agreement Number: 91-03-18- VRX See Section 3.1 for any additional information about the testing environment. As a result of this validation...Department of Defense Washington DC 20301 AVF Control Number: AVF-VSR-470-0491 15-October-1991 91-03-18- VRx Ada COMPILER VALIDATION SUMMARY REPORT
1991-01-22
EXL/320, UNIX System V/386 3.2 Customer Agreement Number: 90-05-29- VRX See Section 3.1 for any additional information about the testing environment. As...Distribution/ Washington DC 20301 Availability Codes 05i jAvail and/or Dist SpeaL&L. AVF Control Number: AVF-VSR-376.0191 22 January 1991 90-05-29- VRX Ada
1994-07-21
InforMation Systems Agency, Center for Information Management DECLARATION OF CONFORMANCE The following declaration of conformance was supplied by the...services such as resource allocation, scheduling, inp•t/outp-it control, and data management. Usually, operating systems are predominantly software...Ada programming language. 1-4 CHAPTER 2 IMPLEMMTION DEPENDENC IES 2.1 WITHDRAWN TESTS The f3llowing tests have been withdrawn by the AVO. The
Rivastigmine for vascular cognitive impairment.
Birks, Jacqueline; McGuinness, Bernadette; Craig, David
2013-05-31
included participants with dementia of different severities. The dose of rivastigmine was different in each study. No pooling of study results was attempted because of these differences between the studies.One trial included 40 participants with subcortical vascular dementia (age range 40 to 90 years) with a mean mini-mental state examination (MMSE) score of 13.0 and 13.4 in the rivastigmine and placebo arms, respectively. Treatment over 26 weeks was limited to 3 mg rivastigmine twice daily, or placebo. No significant difference was found on any outcome measure relevant to cognition, neuropsychiatric symptoms, function or global rating, or in the number of withdrawals before the end of treatment.Another trial included 710 participants with vascular dementia, including subcortical and cortical forms (age range 50 to 85 years). Over 24 weeks, a mean dose of rivastigmine of 9.4 mg/day was achieved versus placebo. Baseline MMSE was identical for both groups, at 19.1. Statistically significant advantage in cognitive response (but not with global impression of change or non-cognitive measures) was seen with rivastigmine treatment at 24 weeks (MMSE change from baseline MD 0.6, 95% CI 0.11 to 1.09, P value 0.02; Vascular Dementia Assessment Scale (VaDAS) change from baseline MD -1.3, 95% CI-2.62 to 0.02, P value 0.05 ). Significantly higher rates of vomiting, nausea, diarrhoea and anorexia and withdrawals from treatment were noted in the participants randomized to rivastigmine compared with placebo (withdrawals rivastigmine 90/365, placebo 48/345, OR 2.02, 95% CI 1.38 to 2.98) (withdrawals due to an adverse event rivastigmine 49/365, placebo 19/345, OR 2.66, 95% CI 1.53 to 4.62, P value 0.0005).The third study included 50 participants (age range 48 to 84 years) with mean MMSE scores of 23.7 and 23.9 in the rivastigmine and placebo arms, respectively. Over a 24-week period, participants labelled as having cognitive impairment but no dementia (CIND) following ischaemic stroke were